Carbocysteine: A compound formed when iodoacetic acid reacts with sulfhydryl groups in proteins. It has been used as an anti-infective nasal spray with mucolytic and expectorant action.Expectorants: Agents that increase mucous excretion. Mucolytic agents, that is drugs that liquefy mucous secretions, are also included here.Cough: A sudden, audible expulsion of air from the lungs through a partially closed glottis, preceded by inhalation. It is a protective response that serves to clear the trachea, bronchi, and/or lungs of irritants and secretions, or to prevent aspiration of foreign materials into the lungs.Bronchial Provocation Tests: Tests involving inhalation of allergens (nebulized or in dust form), nebulized pharmacologically active solutions (e.g., histamine, methacholine), or control solutions, followed by assessment of respiratory function. These tests are used in the diagnosis of asthma.Capsaicin: An alkylamide found in CAPSICUM that acts at TRPV CATION CHANNELS.Angiogenic Proteins: Intercellular signaling peptides and proteins that regulate the proliferation of new blood vessels under normal physiological conditions (ANGIOGENESIS, PHYSIOLOGICAL). Aberrant expression of angiogenic proteins during disease states such as tumorigenesis can also result in PATHOLOGICAL ANGIOGENESIS.Internet: A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.Developing Countries: Countries in the process of change with economic growth, that is, an increase in production, per capita consumption, and income. The process of economic growth involves better utilization of natural and human resources, which results in a change in the social, political, and economic structures.Software: Sequential operating programs and data which instruct the functioning of a digital computer.Ligustrum: A plant genus of the family OLEACEAE. Oleuropein, a phenolic secoiridoid glycoside, is found in the leaves.Medication Errors: Errors in prescribing, dispensing, or administering medication with the result that the patient fails to receive the correct drug or the indicated proper drug dosage.Waiting Lists: Prospective patient listings for appointments or treatments.Medication Adherence: Voluntary cooperation of the patient in taking drugs or medicine as prescribed. This includes timing, dosage, and frequency.Developed Countries: Countries that have reached a level of economic achievement through an increase of production, per capita income and consumption, and utilization of natural and human resources.Helichrysum: A plant genus of the family ASTERACEAE. Members contain CHALCONE, helichrysetin, arenarin, and flamin.Plantago: A plant genus of the family Plantaginaceae. The small plants usually have a dense tuft of basal leaves and long, leafless stalks bearing a terminal spike of small flowers. The seeds, known as PSYLLIUM, swell in water and are used as laxatives. The leaves have been used medicinally.Grindelia: A plant genus of the family ASTERACEAE. Members contain triterpenoid sapogenins.Antitussive Agents: Agents that suppress cough. They act centrally on the medullary cough center. EXPECTORANTS, also used in the treatment of cough, act locally.Iridoid Glucosides: A subclass of iridoid compounds that include a glucoside moiety, usually found at the C-1 position.Quality of Life: A generic concept reflecting concern with the modification and enhancement of life attributes, e.g., physical, political, moral and social environment; the overall condition of a human life.Asthma: A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).Questionnaires: Predetermined sets of questions used to collect data - clinical data, social status, occupational group, etc. The term is often applied to a self-completed survey instrument.Health Status: The level of health of the individual, group, or population as subjectively assessed by the individual or by more objective measures.Physician-Patient Relations: The interactions between physician and patient.Spheniscidae: The sole family in the order Sphenisciformes, comprised of 17 species of penguins in six genera. They are flightless seabirds of the Southern Hemisphere, highly adapted for marine life.RxNorm: A standardized nomenclature for clinical drugs and drug delivery devices. It links its names to many of the drug vocabularies commonly used in pharmacy management.Dictionaries, PharmaceuticTerminology as Topic: The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.Pharmaceutical Preparations: Drugs intended for human or veterinary use, presented in their finished dosage form. Included here are materials used in the preparation and/or formulation of the finished dosage form.Formularies as Topic: Works about lists of drugs or collections of recipes, formulas, and prescriptions for the compounding of medicinal preparations. Formularies differ from PHARMACOPOEIAS in that they are less complete, lacking full descriptions of the drugs, their formulations, analytic composition, chemical properties, etc. In hospitals, formularies list all drugs commonly stocked in the hospital pharmacy.Adverse Drug Reaction Reporting Systems: Systems developed for collecting reports from government agencies, manufacturers, hospitals, physicians, and other sources on adverse drug reactions.Household Products: Substances or materials used in the course of housekeeping or personal routine.Material Safety Data Sheets: Information or data used to ensure the safe handling and disposal of substances in the workplace. Such information includes physical properties (i.e. melting, boiling, flashing points), as well as data on toxicity, health effects, reactivity, storage, disposal, first-aid, protective equipment, and spill-handling procedures.Drug Labeling: Use of written, printed, or graphic materials upon or accompanying a drug container or wrapper. It includes contents, indications, effects, dosages, routes, methods, frequency and duration of administration, warnings, hazards, contraindications, side effects, precautions, and other relevant information.National Library of Medicine (U.S.): An agency of the NATIONAL INSTITUTES OF HEALTH concerned with overall planning, promoting, and administering programs pertaining to advancement of medical and related sciences. Major activities of this institute include the collection, dissemination, and exchange of information important to the progress of medicine and health, research in medical informatics and support for medical library development.Product Labeling: Use of written, printed, or graphic materials upon or accompanying a product or its container or wrapper. It includes purpose, effect, description, directions, hazards, warnings, and other relevant information.Safety: Freedom from exposure to danger and protection from the occurrence or risk of injury or loss. It suggests optimal precautions in the workplace, on the street, in the home, etc., and includes personal safety as well as the safety of property.Hazardous Substances: Elements, compounds, mixtures, or solutions that are considered severely harmful to human health and the environment. They include substances that are toxic, corrosive, flammable, or explosive.Pulmonary Alveolar Proteinosis: A PULMONARY ALVEOLI-filling disease, characterized by dense phospholipoproteinaceous deposits in the alveoli, cough, and DYSPNEA. This disease is often related to, congenital or acquired, impaired processing of PULMONARY SURFACTANTS by alveolar macrophages, a process dependent on GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR.Bronchoalveolar Lavage: Washing out of the lungs with saline or mucolytic agents for diagnostic or therapeutic purposes. It is very useful in the diagnosis of diffuse pulmonary infiltrates in immunosuppressed patients.Granulocyte-Macrophage Colony-Stimulating Factor: An acidic glycoprotein of MW 23 kDa with internal disulfide bonds. The protein is produced in response to a number of inflammatory mediators by mesenchymal cells present in the hemopoietic environment and at peripheral sites of inflammation. GM-CSF is able to stimulate the production of neutrophilic granulocytes, macrophages, and mixed granulocyte-macrophage colonies from bone marrow cells and can stimulate the formation of eosinophil colonies from fetal liver progenitor cells. GM-CSF can also stimulate some functional activities in mature granulocytes and macrophages.Lipoid Proteinosis of Urbach and Wiethe: An autosomal recessive disorder characterized by glassy degenerative thickening (hyalinosis) of SKIN; MUCOSA; and certain VISCERA. This disorder is caused by mutation in the extracellular matrix protein 1 gene (ECM1). Clinical features include hoarseness and skin eruption due to widespread deposition of HYALIN.Double-Blind Method: A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.Dyspnea: Difficult or labored breathing.Amino Acid Transport Disorders, Inborn: Disorders characterized by defective transport of amino acids across cell membranes. These include deficits in transport across brush-border epithelial cell membranes of the small intestine (MICROVILLI) and KIDNEY TUBULES; transport across the basolateral membrane; and transport across the membranes of intracellular organelles. (From Nippon Rinsho 1992 Jul;50(7):1587-92)Patents as Topic: Exclusive legal rights or privileges applied to inventions, plants, etc.Forensic Anthropology: Scientific study of human skeletal remains with the express purpose of identification. This includes establishing individual identity, trauma analysis, facial reconstruction, photographic superimposition, determination of time interval since death, and crime-scene recovery. Forensic anthropologists do not certify cause of death but provide data to assist in determination of probable cause. This is a branch of the field of physical anthropology and qualified individuals are certified by the American Board of Forensic Anthropology. (From Am J Forensic Med Pathol 1992 Jun;13(2):146)Famous PersonsWhooping Cough: A respiratory infection caused by BORDETELLA PERTUSSIS and characterized by paroxysmal coughing ending in a prolonged crowing intake of breath.Bonding, Human-Pet: The emotional attachment of individuals to PETS.Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)Lung Diseases: Pathological processes involving any part of the LUNG.Pulmonary Disease, Chronic Obstructive: A disease of chronic diffuse irreversible airflow obstruction. Subcategories of COPD include CHRONIC BRONCHITIS and PULMONARY EMPHYSEMA.Bromhexine: A mucolytic agent used in the treatment of respiratory disorders associated with viscid or excessive mucus. (From Martindale, The Extra Pharmacopoeia, 30th ed, p744)MedlinePlus: NATIONAL LIBRARY OF MEDICINE service for health professionals and consumers. It links extensive information from the National Institutes of Health and other reviewed sources of information on specific diseases and conditions.

RIT 2214, a new biosynthetic penicillin produced by a mutant of Cephalosporium acremonium. (1/37)

A number of lysine-requiring auxotrophs of Cephalosporium acremonium were investigated for incorporation of side-chain precursors and for accumulation of beta-lactam compounds. One of the auxotrophs, Acremonium chrysogenum ATCC 20389, producing cephalosporin C and penicillin N only if grown in media supplemented with DL-alpha-amino-adipic acid (DL-alpha-AAA), was found to use L-S-carboxymethylcysteine (L-CMC) as a side-chain precursor for the synthesis of a new penicillin (RIT 2214). No corresponding cephalosporin was detected. The penicillin present in the culture filtrate, was concentrated by adsorption on activated carbon and successive column chromatography on Amberlite IRA-68 and Amberlite XAD-4. Final purification was achieved by cellulose column chromatography. RIT 2214 was identified as 6-(D)-[(2-amino-2-carboxy)-ethylthio]-acetamido]-penicillanic acid by spectral analysis, bioactivity spectrum, elucidation of side-chain structure and finally by semisynthesis. Its biological properties were also evaluated.  (+info)

Diurnal variation in the metabolism of S-carboxymethyl-L-cysteine in humans. (2/37)

The routes of metabolism of S-carboxymethyl-L-cysteine in humans are dependent on the time of dosing. Administration of 750 mg of S-carboxymethyl-L-cysteine (Day 1) during the day at 8:00 AM followed by a 8:00 AM to 4:00 PM urine collection revealed that S-carboxymethyl-L-cysteine S-oxide was the major urinary metabolite produced. The 4:00 PM to midnight urine collection resulted in S-(carboxymethylthio)-L-cysteine being identified as the major urinary metabolite. However, the administration of 750 mg of S-carboxymethyl-L-cysteine (day 15) during the night at midnight and analysis of the midnight to 8:00 AM urine collection found that thiodiglycolic acid was the major urinary metabolite, whereas thiodiglycolic S-oxide was identified as the major urinary metabolite in the 8:00 AM to 4:00 PM urine collection. A diurnal variation in the metabolism of S-carboxymethyl-L-cysteine was seen and, in particular, the timing of S-carboxymethyl-L-cysteine administration had a profound effect on the identity of urinary S-oxide metabolites produced. After administration at 8:00 AM the urinary S-oxides produced were S-carboxymethyl-L-cysteine S-oxide and S-methyl-L-cysteine S-oxide but at midnight the major urinary S-oxide metabolite produced was thiodiglycolic acid S-oxide.  (+info)

Effects of carbocysteine on antigen-induced increases in cough sensitivity and bronchial responsiveness in guinea pigs. (3/37)

Carbocysteine is a mucoactive drug and is being used for both acute and chronic infectious airway diseases. Although carbocysteine can repair the damage of epithelial cells caused by exposure to various agents, the effects of this agent on allergic airway diseases such as asthma and eosinophilic bronchitis with an isolated chronic cough, in both of which epithelial damage may be characteristic, is not clear. We investigated the effects of carbocysteine on antigen-induced cough hypersensitivity to inhaled capsaicin at 48 h and bronchial hyperresponsiveness to inhaled methacholine at 72 h after challenge with an aerosolized antigen in actively sensitized guinea pigs. After measuring bronchial responsiveness, we examined neutral endopeptidase (NEP) activity in the tracheal tissue. Carbocysteine (10, 30, or 100 mg/kg) was given intraperitoneally every 12 h for 3 days after antigen challenge. The number of coughs elicited by an aerosol of capsaicin (10(-4) M) was significantly (p < 0.01) decreased in carbocysteine groups (6.13 +/- 0.59 at 10 mg/kg, 4.88 +/- 0.67 at 30 mg/kg, and 4.50 +/- 0.33 at 100 mg/kg during 3 min measurement) compared with the control group (9.75 +/- 0.53). Furthermore, carbocysteine dose dependently repaired the antigen-induced decrease of NEP activity in the tracheal tissue, but it did not influence the bronchial hyperresponsiveness or bronchoalveolar lavage cell component. These findings suggest that carbocysteine promotes the repair of damaged epithelium by allergic reaction and may be useful in allergic airway diseases accompanied by isolated chronic coughing, especially eosinophilic bronchitis without asthma and tracheobronchitis with cough hypersensitivity.  (+info)

Does early detection of otitis media with effusion prevent delayed language development? (4/37)

OBJECTIVE: To consider whether earlier detection of otitis media with effusion (OME) in asymptomatic children in the first 4 years of life prevents delayed language development. METHODS: MEDLINE and other databases were searched and relevant references from articles reviewed. Critical appraisal and consensus development were in accordance with the methods of the Canadian Task Force on Preventive Health Care. RESULTS: No randomised controlled trials assessing the overall screening for OME and early intervention to prevent delay in acquiring language were identified, although one trial evaluated treatment in a screened population and found no benefit. The "analytic pathway" approach was therefore used, where evidence is evaluated for individual steps in a screening process. The evidence supporting the use of tools for early detection such as tympanometry, microtympanometry, acoustic reflectometry, and pneumatic otoscopy in the first 4 years of life is unclear. Some treatments (mucolytics, antibiotics, steroids) resulted in the short term resolution of effusions as measured by tympanometry. Ventilation tubes resolved effusions and improved hearing. Ventilation tubes in children with hearing loss associated with OME benefited children in the short term, but after 18 months there was no difference in comparison with those assigned to watchful waiting. Most prospective cohort studies that evaluated the association between OME and language development lacked adequate measurement of exposure or outcome, or suffered from attrition bias. Findings with regard to the association were inconsistent. CONCLUSIONS: There is insufficient evidence to support attempts at early detection of OME in the first 4 years of life in the asymptomatic child to prevent delayed language development.  (+info)

S-carboxymethylcysteine in the treatment of glue ear: quantitative systematic review. (5/37)

OBJECTIVE: To establish the clinical relevance of S-carboxymethylcysteine in the treatment of glue ear in children using measures approximating those saving a child from operation for grommet insertion. DATA SOURCES: Cochrane Library, MEDLINE, EMBASE, PubMed, reference lists and reviews were used for randomised controlled trials comparing S-carboxymethylcysteine with placebo. Seven trials involving 283 children and 146 ears were found. REVIEW METHODS: Studies were randomised, double-blind comparisons of S-carboxymethylcysteine (any dose and duration) with placebo in otitis media with effusion. Quality of trial reporting and validity of methods were assessed and used in sensitivity analysis. Main outcomes were relative benefit and number-needed-to-treat to prevent one grommet operation compared with placebo. RESULTS: Successful outcomes were obtained in 17% of children given placebo (range 5% to 38% in individual studies) and in 35% of children given S-carboxymethylcysteine (range 22 to 80%). For combined data (children and ears) the relative benefit was 2.0 (95%CI 1.4 to 2.8) and number-needed-to-treat 5.5 (95% confidence interval 3.8 to 9.8). Pooled data from trials of higher reporting quality (4/7) or methodological validity (3/7) tended to have lower efficacy but were not statistically different from those of lower quality or validity. CONCLUSION: S-carboxymethylcysteine is effective in the treatment of children with glue ear. For every five or six children treated with S-carboxymethylcysteine over one to three months, one will not undergo surgery for grommet insertion who would have done had they been given placebo. The confidence in this conclusion is limited because studies included relatively few children.  (+info)

Insights into the mechanisms of ifosfamide encephalopathy: drug metabolites have agonistic effects on alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)/kainate receptors and induce cellular acidification in mouse cortical neurons. (6/37)

Therapeutic value of the alkylating agent ifosfamide has been limited by major side effects including encephalopathy. Although the underlying biochemical processes of the neurotoxic side effects are still unclear, they could be attributed to metabolites rather than to ifosfamide itself. In the present study, the effects of selected ifosfamide metabolites on indices of neuronal activity have been investigated, in particular for S-carboxymethylcysteine (SCMC) and thiodiglycolic acid (TDGA). Because of structural similarities of SCMC with glutamate, the Ca(2+)(i) response of single mouse cortical neurons to SCMC and TDGA was investigated. SCMC, but not TDGA, evoked a robust increase in Ca(2+)(i) concentration that could be abolished by the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)/kainate receptor antagonist 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX), but only partly diminished by the N-methyl-D-aspartate receptor antagonist 10,11-dihydro-5-methyl-5H-dibenzo[a,d]cyclohepten-5,10-imine (MK=801). Cyclothiazide (CYZ), used to prevent AMPA/kainate receptor desensitization, potentiated the response to SCMC. Because activation of AMPA/kainate receptors is known to induce proton influx, the intracellular pH (pH(i)) response to SCMC was investigated. SCMC caused a concentration-dependent acidification that was amplified by CYZ. Since H(+)/monocarboxylate transporter (MCT) activity leads to similar cellular acidification, we tested its potential involvement in the pH(i) response. Application of the lactate transport inhibitor quercetin diminished the pH(i) response to SCMC and TDGA by 43 and 51%, respectively, indicating that these compounds may be substrates of MCTs. Taken together, this study indicates that hitherto apparently inert ifosfamide metabolites, in particular SCMC, activate AMPA/kainate receptors and induce cellular acidification. Both processes could provide the biochemical basis of the observed ifosfamide-associated encephalopathy.  (+info)

Effect of carbocysteine on cough reflex to capsaicin in asthmatic patients. (7/37)

AIMS: Cough, one of the main symptoms of bronchial asthma, is a chronic airway inflammatory disease with functionally damaged bronchial epithelium. Recently, we established an animal model with cough hypersensitivity after antigen challenge and clearly showed the protective effect of carbocysteine in this model. This study was designed to investigate the clinical effect of carbocysteine for cough sensitivity in patients with bronchial asthma. METHODS: The effects of the two orally active mucoregulatory drugs, carbocysteine and ambroxol hydrochloride, on cough response to inhaled capsaicin were examined in 14 patients with stable asthma. Capsaicin cough threshold, defined as the lowest concentration of capsaicin eliciting five or more coughs, was measured as an index of airway cough sensitivity. RESULTS: Geometric mean values of the cough threshold at run-in (baseline) and after 4 weeks' treatment of placebo, 1500 mg day-1 of carbocysteine and 45 mg day-1 of ambroxol hydrochloride were 12.8 micro M (95% confidence interval [CI] 5.5, 29.6), 11.0 micro M (95% CI 4.4, 27.5), 21.0 micro M (95% CI 8.8, 50.2) and 11.6 micro M (95% CI 5.8, 23.3), respectively. The cough threshold for carbocysteine was significantly greater than those of ambroxol hydrochloride (P = 0.047) and placebo (P = 0.047), respectively. CONCLUSIONS: These findings indicate that carbocysteine administration may be a novel therapeutic option for asthmatic patients, especially with cough variant asthma.  (+info)

Study about the inhibition of L-cysteine derivatives of nucleic acid bases in protein production. (8/37)

Isopoly (S-carboxymethyl-L-cysteine) derivatives of nucleic acids bases were prepared as antisense compounds. In past study, we investigated the properties of these compounds in vitro, and revealed that these compounds in vivo regulated the cell death presumably due to the inhibition of protein production. In this study, western and northern blots were carried out in order to reveal the mechanism of this inhibition for N-methyl-D-aspartate receptor in neuroblastoma x glioma hybrid NG108-15 cell line. In addition, we investigated the resistance of these compounds against cell extract and the metabolism. In conclusion, we proved that these compounds inhibited the protein production by antisense mechanism.  (+info)

*List of MeSH codes (D12.125)

... carbocysteine MeSH D12.125.119.307 --- cystathionine MeSH D12.125.119.369 --- cystine MeSH D12.125.119.450 --- glutamic acid ... carbocysteine MeSH D12.125.166.230.330 --- cysteinyldopa MeSH D12.125.166.230.369 --- cystine MeSH D12.125.166.230.700 --- ...

*List of MeSH codes (D02)

... carbocysteine MeSH D02.886.030.230.330 --- cysteinyldopa MeSH D02.886.030.230.369 --- cystine MeSH D02.886.030.230.700 --- ...

*Carbocisteine

... (INN), also called carbocysteine (USAN), is a mucolytic that reduces the viscosity of sputum and so can be used ...
S-карбоксиметил-L-цистеин е карбоксиметил дериватот на страничен ланец на цистеин. Исто така е наречен Carbocisteine ​​или Carbocysteine. S-карбоксиметил-L-цистеин
Health,...Carbocisteine reduced exacerbation of the lung condition by 25% Chine...THURSDAY June 12 (HealthDay News) -- In people suffering from chronic...COPD is a progressive destructive disease of the lungs usually broug... COPD is a major respiratory disease that affects many people especi...,Anti-Mucus,Drug,Slows,Symptoms,of,COPD,medicine,medical news today,latest medical news,medical newsletters,current medical news,latest medicine news
Mucolytic medicines, such as carbocisteine, can be helpful for people with a long-term respiratory disease such as chronic obstructive pulmonary disease (COPD).. Carbocisteine works by making phlegm (mucus) less thick and sticky, and therefore easier to cough up. It may also have a knock-on effect of making it harder for germs (bacteria) to cause chest infections.. It needs to be taken regularly, and is most likely to help if you have moderate or severe COPD and have frequent or bad flare-ups.. ...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies. ...
Reodyn information about active ingredients, pharmaceutical forms and doses by Orion Pharma, Reodyn indications, usages and related health products lists
Steventon GB. Diurnal variation in the metabolism of S-carboxymethyl-L-cysteine in humans. Drug Metab Dispos. 1999 Sep;27(9):1092-7. PMID: 10460812.. Synge RL, Wood JC. (+)-(S-methyl-L-cysteine S-oxide) in cabbage. Biochem J. 1956 Oct;64(2):252-9. PMID: 13363835. ...
Bridging Small Molecules to Modified Bacterial Microparticles Using a Disulphide Linkage: MIS416 as a Cargo Delivery System. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
Answers from specialists on carbocistine. First: Neulasta (pegfilgrastim) is a long-acting injection that increases your white blood cells. It should only be given during a two or three week window when youre not receiving chemotherapy. If youre receiving Taxol every week, you should not receive neulasta (pegfilgrastim). If you do, the Taxol can kill the dividing white blood cells, and harm your bone marrow stem cells. It is not fda-approved to give during weekly chemo!
This item is new and never used, in original container, authentic. Safe - Effective - Lasts for Months. Enough For Five (5) Treatments! Cezanne Perfect Finish Keratin Smoothing Treatment (CPF) is different. It is a 100% formaldehyde free, next generation smoothing system that uses the latest advances in science, along with only the finest ingredients, to create a product that delivers the results of a traditional keratin smoothing treatment without the harmful chemicals. It works on all hair types and lasts for months, depending on hair type and after care of the hair. Results last as long as or longer than any formaldehyde systems on the market, but without the harmful chemicals. Using the best quality ingredients and without unpleasant odor, CPF outperforms and outlasts carbocisteine and amino acid products, and CPF doesnt break the disulfide bonds, which can be damaging to the hair. Is unique in that it works from the inside out in changing the overall health and shape of the curl. What kind ...
I have the flu. Can I take solmux and alaxan at the same time for flu treatment? If so, how many times a day? ## Solmux contains Carbocisteine and is use to treat cough that is due to excessive sticky phlegm, Alaxan contains Paracetamol and Ibuprofen, it is used to treat pain, fever, and swelling. T
Chronic inflammation seems to induce alterations in nasal mucosa morphology. The type and extent of these alterations seem to be directly correlated with the duration of the inflammation. This study was carried out to ascertain whether the administration of muco-active drugs could modify these alterations by inducing their total or partial regression. Ten healthy control subjects, and thirty patients affected with chronic rhinopharyngitis, at various levels of severity, were studied. All the forty subjects underwent biopsy of the posterior region of the medium turbinate. The bioptic samples were examined using Scanning Electron Microscopy (SEM). Patients with phlogosis underwent treatment which consisted of a single day administration of carbocysteine-sobrerol (1125 mg carbocysteine and 180 mg sobrerol day 20 days). This group underwent biopsy again and the fragments obtained were studied using the same method. Chronic inflammation, in the nasal epithelium, causes progressive degenerative ...
10.5 eV. The ion at m/z 199 is assigned to the loss of water after loss of ammonia from Mþ after intramolecular hydrogen an intramolecular hydrogen transfer process, as shown in transfer, which is a similar pathway to the CID behavior of Scheme 1. A relatively low-intensity fragment ion at m/z 171 the fudosteine derivative bis-methylated carbocysteine in is due to the subsequent loss of CO from m/z 199. Loss of the ESI-MS.32 The low-intensity ion at m/z 134 is due to the loss of mercapto radical (SH) from Mþ results in the fragment ion at a hydrocarboxyl radical from Mþ. Cysteine is known to m/z 184. Intramolecular hydrogen transfer and subsequent undergo the loss of a hydrocarboxyl radical to yield its most decarboxylation processes then occur with the loss of carbon abundant fragment ion.31 This discrepancy between the high dioxide from m/z 184 to yield the ion at m/z 140. Another intensity of the fragment ion in cysteine and the low intensity major pathway for formation of the m/z 140 ion ...
Search results for Oxacillin sodium salt monohydrate at Glentham Life Sciences. Find catalogue prices, chemical data, technical specifications and MSDS documents.
Hi Histonetters, We are working with mouse and rabbit trachea and are experiencing problems with the histology. We are seeing fragmentation, lifting off and ultimate destruction of the epithelial and underlying layers. This does not happen with all samples but is occuring far too often. We are fixing the mouse tissue in formalin 18-24 hrs at 4C and then transferring to 70% ETOH. The rabbit tissue is fixed in formalin at 4C for 24 hrs and then processed. We are using alcohols for dehydration and xylene for clearing. I see where other folks are using different dehydrants etc for mouse tissue but this is not an option for us at the moment. We have processed for very short durations and longer but still see quite a bit of variation. We are doing routine staining of the tissue as well as some immunohistochemistry. Do you have suggestions for fixatives and length and temperature of fixation? Suggestions for processing protocols, ie length, temp use of vacuum? Suggestions for ideal paraffin? Thanks, ...
Quinine hemisulfate salt monohydrate tested according to Ph Eur; CAS Number: 207671-44-1; Synonym: Chinini sulfas, Quinine sulfate (2:1) (salt) dihydrate; Linear Formula: C20H24N2O2 · 0.5H2O4S · H2O; find Sigma-Aldrich-22642 MSDS, related peer-reviewed papers, technical documents, similar products & more at Sigma-Aldrich.
Quinine hemisulfate salt monohydrate BioReagent, suitable for fluorescence, 99.0-101.0%; CAS Number: 207671-44-1; Synonym: Quinine sulfate (2:1) (salt) dihydrate; Linear Formula: C20H24N2O2 · 0.5H2O4S · H2O; find Sigma-Aldrich-22640 MSDS, related peer-reviewed papers, technical documents, similar products & more at Sigma-Aldrich.
2,5-Dichlorobenzenesulfinic acid sodium salt monohydrate/ACM175278634 can be provided in Alfa Chemistry. We are dedicated to provide our customers the best products and services.
[65 Pages Report] Check for Discount on Phenylpyruvic acid, sodium salt monohydrate Global Market and Forecast Research report by ChemReport. DescriptionWe provide independent and unbiased information on manufacturers, prices, production...
Tracheobronchial mucus hypersecretion contributes to the symptoms of COPD and is associated with an increased risk of hospital admission and an accelerated decline in FEV1.1 Nevertheless, evidence that oral mucolytic agents have an important clinical effect has been limited, and routine use of such agents is not recommended in the latest COPD guidelines published by the European Respiratory Society,2 British Thoracic Society,3 American Thoracic Society,4 and Global Initiative for COPD (National, Heart, Lung, and Blood Institute and World Health Organization).5. The systematic review by Poole and Black provides a helpful analysis of relevant trials: 23 randomised controlled trials of 10 different agents. Overall, mucolytic agents provided a modest reduction in both the number and duration of symptomatic exacerbations, but lung function was not improved and hospital admission rates were not reported. The most widely studied medication was acetylcysteine (12 studies), and the antioxidant properties ...
in JAMA Neurology (2015). IMPORTANCE Although typical forms of Alzheimer disease (AD) and Creutzfeldt-Jakob disease (CJD) are clinically distinguishable, atypical AD phenotypesmay pose a diagnostic challenge. The major biological ... [more ▼]. IMPORTANCE Although typical forms of Alzheimer disease (AD) and Creutzfeldt-Jakob disease (CJD) are clinically distinguishable, atypical AD phenotypesmay pose a diagnostic challenge. The major biological diagnostic biomarker for identifying CJD, 14-3-3 protein in cerebrospinal fluid (CSF), unfortunately lacks specificity when confronting a rapid dementia presentation. OBJECTIVE To assess the relevance of total CSF prion protein (t-PrP) levels in the differential biological diagnosis between atypical AD phenotypes and CJD. DESIGN, SETTING, AND PARTICIPANTS A retrospective study in an autopsy-confirmed cohort of 82 patients was performed to evaluate the relevance of CSF t-PrP to distinguish 30 definite cases of AD from 52 definite cases of CJD. Next, CSF ...
Recent studies have shown that a major functional relationship exists between fibrillin-1 and TGFβ activity (for reviews see Ramirez et al., 2004; Dietz et al., 2005). Fibrillin-1 is postulated to regulate TGFβ through the association of LLC with fibrillin-rich microfibrils, although it is not clear how this regulation occurs. We have discovered that a specific fibrillin-1 sequence encoded by exons 44-49 (in recombinant fragments PF10 and PF11) enhances endogenous active TGFβ1 and Smad2 signaling. This sequence, which is present within a pepsin-resistant microfibril proteolytic fragment (Maslen et al., 1991), contains no TB motif such as those in LTBP-1 and -3 that bind LAP through disulphide linkage (for review see Hyytiäinen et al., 2004). Thus, fibrillin-1 enhances active TGFβ1 by a novel mechanism and may contribute directly to the lung, skeletal, and vascular pathologies of MFS and related diseases.. We excluded the idea that purified PF10 or PF11 contained traces of latent or active ...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Hello and thanks for posting. Many get confused as to what is a first- or second-line HIV regimen. One way to look at this is by defining the regimen by whether the virus is drug resistant or...
It is very rare for an MRI of the brain to remain normal for prolonged periods of time in definite cases of MS. There is limited data on the topic, but most people with MS develop brain abnormalities within 5 years, if not sooner. These people also tend to experience a more benign form of MS. There are many conditions that causes symptoms and findings similar to MS and there is no reason to rush into a diagnosis. The real question is why are you so convinced you have MS and why would you want to rush the diagnosis ...
A doctor I visited recently has just diagnosed me with Lyme Disease. He says that I have 3 bands of the 5 needed for most doctors or insurance companies to believe I have Lyme. Apparently they test for 10 strands and you must test positive for 5 out of the 10, or something like that. For them to consider it a definite case of Lyme. He claims he is fully confident that I have Lyme(because I have the most telling band), but Ive been through soo much for so long that its hard to trust anybody. Why wouldnt the CDC recognize it as a disease? What would they have to lose? Im just scared of being sold snake oil and a bill of junk. Trust me, I want so badly to have Lyme disease or any disease for that matter. Anything to tackle, instead of wallowing in this generic severe chronic pain, that is only a little less desirable than death. Give me something to fight against and Ill do it. Im only 26 and feel like Ill fight with all I have, I just need to know what Im supposed to battle. But I just ...
Mantovani G, Macciò A, Massa E, et al. Managing cancer-related anorexia/cachexia. Drugs. 2001;61:499-514. Bruera E, Strasser F, Palmer JL, et al. Effect of fish oil on appetite and other symptoms in patients with advanced cancer and anorexia/cachexia: a double-blind, placebo-controlled study. J Clin Oncol. 2003;21:129-134. Barber MD. Cancer cachexia and its treatment with fish-oil-enriched nutritional supplementation. Nutrition. 2001;17:751-755. Tisdale MJ, Dhesi JK. Inhibition of weight loss by omega-3 fatty acids in an experimental cachexia model. Cancer Res. 1990;50:5022-5026. Yang M, Cook ME. Dietary conjugated linoleic acid decreased cachexia, macrophage tumor necrosis factor-alpha production, and modifies splenocyte cytokines production. Exp Biol Med (Maywood). 2003;228:51-58. Tisdale MJ, Brennan RA. A comparison of long-chain triglycerides and medium-chain triglycerides on weight loss and tumour size in a cachexia model. Br J Cancer. 1988;58:580-583. Inui A. Cancer anorexia-cachexia ...
Optical characterization of a new donor-acceptor type conjugated polymer derived from 3,4-diphenylthiophene. Manjunatha, M. G.; Adhikari, Airody Vasudeva; Hegde, Pramod Kumar; Sandeep, C. S. Suchand; Philip, Reji // Journal of Materials Science;Nov2009, Vol. 44 Issue 22, p6069 A new donorâ€"acceptor type poly{2-(3,4-didecyloxythiophen-2-yl)-5-[3,4-diphenyl-5-(1,3,4-oxadiazol-2-yl)thiophen-2-yl]-1,3,4-oxadiazole} ( P1) has been designed and synthesized starting from thiodiglycolic acid, 1,2-diphenylethane-1,2-dione, and diethyl oxalate through multi-step reactions... ...
A Turkish family with Huntingtons disease documented on CT, MRI and SPECT is reported. Whereas in clinically definite cases CT and MRI are of limited value and SPECT does not add anything of value,...
Mucophylline Syrup Mucolytic, Bronohodilator Composition: Each teaspoonful (5ml) contains: Bromhexine hydrochloride 4 mg. Acephylline piperazine 10
View mouse St6gal1 Chr16:23224740-23360350 with: phenotypes, sequences, polymorphisms, proteins, references, function, expression
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Thank you for your interest in spreading the word on American Association for Respiratory Care.. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.. ...
Common disorders of childhood and adolescence are attention-deficit/hyperactivity disorder (ADHD), oppositional defiant disorder (ODD) and conduct disorder (CD). For one to two cases in three diagnosed with ADHD the disorders may be comorbid. However, whether comorbid conduct problems (CP) represents a separate disorder or a severe form of ADHD remains controversial. We investigated familial recurrence patterns of the pure or comorbid condition in families with at least two children and one definite case of DSM-IV ADHDct (combined-type) as part of the International Multicentre ADHD Genetics Study (IMAGE). Using case diagnoses (PACS, parental account) and symptom ratings (Parent/Teacher Strengths and Difficulties [SDQ], and Conners Questionnaires [CPTRS]) we studied 1009 cases (241 with ADHDonly and 768 with ADHD + CP), and their 1591 siblings. CP was defined as , or =4 on the SDQ conduct-subscale, and T , or = 65, on Conners oppositional-score. Multinomial logistic regression was used to ...
Looking for Mucomist? Find out information about Mucomist. HSCH2CH COOH Crystals with a melting point of 109-110°C; used as a mucolytic drug Explanation of Mucomist
EDITOR,-Cystic fibrosis is the most common serious autosomal recessive condition in white populations, affecting about 1 in 2500 live births, and until recently life expectancy rarely exceeded 30 years. The most common cystic fibrosis mutation (δF508, accounting for about 80% of two million British carriers), is a 3-bp deletion in a transmembrane protein cystic fibrosis transmembrane regulator gene. The next most common three or four mutations account for a further 5% of carriers.. One in 25 white people carries cystic fibrosis. As carriers are unaffected, individuals are often unaware until … ...
ananyo writes Scientists have demonstrated that several lab-made variants of DNA can store and transmit information much like the genuine article. DNA is made up of nucleic acid bases — labelled A, C, G and T — on a backbone made of phosphates and the sugar deoxyribose. The artificial p...
SPE Supra-Poly XWP Column, 60 mg/3 mL is recommended for extracting polar and non-polar compounds when analyzing drugs and drug metabolites biological fluids.
SPE Supra-Poly XC Column, 60 mg/3 mL is recommended for extracting polar and non-polar compounds when analyzing drugs and drug metabolites biological fluids.
SPE Supra-Poly XC 60 mg/3 mL is recommended for extracting polar and non-polar compounds when analyzing drugs and drug metabolites biological fluids.
Ataluren (PTC 124; PTC Therapeutics),18 currently recognized as an orphan drug by the FDA, is a more appealing therapeutic option for class I CFTR defects. In a mechanism similar to the pleiotropic effects of aminoglycosides, ataluren allows ribosomes to read through the mRNA premature stop codons, resulting in the translation of complete CFTR proteins.19,20 Several phase II and III studies19-21 have evaluated this drugs efficacy and demonstrated improvements in nasal transepithelial potential differences, forced expiratory volume in 1 second (FEV1), and weight gain in both adult and pediatric patient populations.20 Adverse effects were generally mild, with gastrointestinal upset, headache, and dizziness most commonly reported (Table 2). Because of its efficacy in targeting the underlying cause of CF and favorable adverse effect profile, ataluren is considered the more appropriate initial approach compared with aminoglycosides in patients with CF who have class I mutations.10,21 Several phase ...
Cephalosporium stripe, caused by the soil-borne ascomycete Cephalosporium gramineum, is becoming an increasingly important disease of winter wheat (Triticum aestivum) in several areas of the world, especially where stubble mulch is practiced to maintain soil moisture and prevent erosion. As cultural control of the disease is infeasible and no fungicides are registered, the development of resistant cultivars offers the best hope for disease control. Selection of resistant genotypes remains problematic due to the requirements of evaluating adult plants in variable field environments. The symptoms of cephalosporium stripe suggest the involvement of pathogen-produced toxins, and the toxin called graminin A has previously been isolated from C. gramineum. The goals of this thesis were to determine if insensitivity of wheat genotypes to a toxic fraction produced by C. gramineum is associated with resistance to cephalosporium stripe, and to evaluate the potential use of this toxic fraction to screen ...
The first mention of tungsten and its compounds can be traced to about 1761. German chemist Johann Gottlob Lehmann (1719-67) was studying a mineral known as wolframite. He found two new substances in the mineral but did not recognize that they were new elements. About twenty years later, Scheele also studied this mineral. He produced from it a white acidic powder. Scheele knew the powder was a new substance. But he could not isolate a pure element from it. Scheeles discovery was actually tungstic acid (H 2 WO 4 ). (See sidebar on Scheele in the chlorine entry in Volume 1.) Tungsten metal was prepared for the first time in 1783 by the DElhuyard brothers. In 1777, they were sent to Sweden to study mineralogy. After their return to Spain, the brothers worked together on a number of projects. One project involved an analysis of wolframite. They produced tungstic acid like Scheele but went one step further. They found a way to obtain pure tungsten metal from the acid. For this work, they are ...
Results: The average annualised incidence of definite cases of ARF in children aged 5-15 years was 15.2 per 100 000 (95% CI, 9.0-22.6). The clinical features of ARF were similar to those in classic descriptions. Carditis was very common, occurring in 79% of cases. There were 103 admissions for RHD in which detailed information was collected, with the most common reason for admission being cardiac failure (51%). The median age at admission with RHD was 26.8 years, and there were 10 deaths of patients with RHD (case fatality rate, 9.7 ...
TY - JOUR. T1 - Differentiated structure and function of cultures from human tracheal epithelium. AU - Yamaya, M.. AU - Finkbeiner, W. E.. AU - Chun, S. Y.. AU - Widdicombe, Jonathan. PY - 1992. Y1 - 1992. N2 - Here we describe the conditions which allow cultured human tracheal epithelial cells to retain the ion transport properties and ultrastructure of the original tissue. The order of potency of growth supports and media additives in elevating baseline short-circuit current (I(sc)) and responses to mediators were vitrogen gel (VIT) , extracellular matrix from bovine corneal endothelial cells (ECM) , human placental collagen (HPC), and 2% Ultroser G serum substitute (USG) , 5% fetal calf serum (FCS) , defined growth factors (GF). For all combinations of medium and growth supports, an air interface (AIR) gave better electrical properties than immersion feeding (IMM). As opposed to our earlier conditions (HPC/FCS/IMM), the best new combination (VIT/USG/AIR) produced higher baseline I(sc) (58.0 ...
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Cystic Fibrosis Overview What is cystic fibrosis? Cystic fibrosis (CF) is an inherited disease characterized by an abnormality in the bodys salt, water- and mucus-making cells. It is chronic, progressive, and is usually fatal. In general, children with CF live into their 30s. Children with CF have an abnormality in the function of a cell protein called the cystic fibrosis transmembrane regulator (CFTR). CFTR controls the flow of water and certain salts in and out of the bodys cells. As the movement of...
In some patients with cystic fibrosis (CF), the disease is caused by a nonsense mutation (premature stop codon) in the gene that makes the cystic fibrosis transmembrane regulator (CFTR) protein. PTC124 has been shown to partially restore CFTR production in animals with CF due to a nonsense mutation. In an ongoing Phase 2a study being performed at the Hadassah University Hospital - Mount Scopus in Israel, patients with nonsense-mutation-mediated CF have received PTC124 in two 14-day treatment courses. Preliminary results from that study indicate that PTC124 has pharmacodynamic activity of PTC124 in CF and that PTC124 can be safely administered in this patient population. This Phase 2b extension study is designed to evaluate the activity and safety of 3 months (approximately 84 days) of continuous treatment with PTC124 in the same patients who were enrolled to the Phase 2a study. The main purpose of this study is to understand whether PTC124 can be safely administered and achieve pharmacodynamic ...
Ive had asthma since I was little, and as far as Ive gathered, expectorant is for non-asthmatic cough sufferers while mucolytics are for asthmatics. Is this true? Whats confusing me though is why ...
Background Anorexia Cachexia syndrome (ACS) is a common and devastating condition in cancer patients. It is poorly defined and heterogeneous, with many difficulties in conducting research and translating those findings into practice. A literature review revealed that patients experience of the care offered by healthcare professionals was generally negative. Professionals were seen to avoid the issue or offer scanty/ineffective advice. It was hypothesised that proactive, systematic management could overcome some of these barriers. This was seen in an interventional study of such an approach, QISAM (Quantifying the impact of Standardised Assessment and Management).. ...
NAC GOOD FOR ** **URIs particularly useful for treating upper respiratory and lung infections; mucolytic classic study published in 1997: may not even notice being sick NAC significantly reduced flu-like episodes **OCD case report of a single patient with OCD who benefited from taking NAC was…
Determination of drug or drug metabolite concentrations in biological samples, particularly in serum or plasma, is fundamental to describing the relationships between administered dose, route of administration, and time after dose for achieving the optimal clinical response
Approximately 30,000 people in the United States have been diagnosed with CF, which affects both males and females. Its not contagious, so you cant catch CF from another person.. Cystic fibrosis is an inherited disease caused by mutations (changes) in a gene on chromosome 7, one of the 23 pairs of chromosomes that children inherit from their parents. CF occurs because of mutations in the gene that makes a protein called CFTR (cystic fibrosis transmembrane regulator). A person with CF produces abnormal CFTR protein - or no CFTR protein at all, which causes the body to make thick, sticky mucus instead of the thin, watery kind.. People who are born with CF have two copies of the CF gene. In almost all people born with CF, one gene is received from each parent. This means that the parents of kids with CF are usually both CF carriers - that is, they have one normal and one defective gene - but the parents may not have CF themselves because their normal gene is able to "take over" and make the ...
Toyonaga, Y.; Ishihara, T.; Tezuka, T.; Nakamura, H., 1995: Bacteriological, pharmacokinetic and clinical studies of SY5555 dry syrup in the pediatric field
Japans largest platform for academic e-journals: J-STAGE is a full text database for reviewed academic papers published by Japanese societies
I feel like i can see a second line, but Im not very sure. Can anyone tweak this for me please and give me your thoughts? Thank you
Creation of isopenicillin N from δ-(L-α-aminoadipyl)-L-cysteinyl-D-valine (ACV) in the penicillin and cephalosporin biosynthetic pathway is catalysed by isopenicillin N synthase (IPNS), a non-heme iron-containing dioxygenase. A tripeptide R-X-S motif which consists of arginine-281 and serine-283 (Cephalosporium acremonium IPNS numbering) was found to be conserved in IPNS and other related proteins. These two amino acids mentioned were proposed to have a role in ACV substrate binding by the recent Aspergillus nidulans IPNS crystal structure. Using site-directed mutagenesis, arginine-281 in C. acremonium IPNS (cIPNS) was earlier found to be essential for catalysis by our group. Similarly, serine-283 in cIPNS was also altered by site-directed mutagenesis to determine its role in cIPNS. No measurable activity was detected from the resultant mutant using enzyme bioassays. It is most likely that the elimination of the mutants substrate-binding capability similar to that of arginine-281 lead to the ...
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Involved in the endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Prevents formation of cytosolic aggregates of unfolded glycoproteins that have been retrotranslocated into the cytosol. Able to recognize and bind denatured glycoproteins, preferentially those of the high-mannose type (By similarity).
A new drug is proven to offer significantly better outcomes for patients with non-small cell lung cancer who experience this debilitating side effect.
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Beneficial in both productive and dry cough for diabetic patient. The mucolytic and expectorant properties reduces the viscosity of bronchial secretions and facilitate expectoration ...
Preamble: Stanford points out that the average 70-year-old is on 7 (seven) pharmaceutical agents1. Since literally hundreds of potential adverse reactions can occur with each medication, imagine the potential for cross reactivity (same reference quotes an average number of potential side effects per drug to be 69)…especially if a drugs metabolite can impart adverse reactions too?
Isopenicillin N synthase (IPNS) catalyses a key step in the penicillin and cephalosporin biosynthetic pathway which involves the oxidative cyclisation of the acyclic peptide δ-(L-α-aminoadipyl)-L-cysteinyl-D-valine (ACV) to isopenicillin N. Based on crystallographic evidence from the Aspergillus nidulans IPNS crystal structure complexed with the substrate ACV (Roach et al. (1997) Nature 387, 827-830), we were able to provide mutational evidence for the critical involvement of the conserved R-X-S motif in ACV binding in IPNS. The crystal structure further implicated arginine-87 in the binding of the aminoadipyl portion of ACV. Thus, in this study, the site-directed mutagenesis of the corresponding arginine-89 in Cephalosporium acremonium IPNS (cIPNS) was performed to ascertain its role in cIPNS. Alteration of arginine-89 to five amino acids from different amino acid groups, namely lysine, serine, alanine, aspartate and leucine, was performed and no activity was detected in all the mutants ...
Looking for mercapturic acid? Find out information about mercapturic acid. HSCH2CH COOH Crystals with a melting point of 109-110°C; used as a mucolytic drug Explanation of mercapturic acid
Introduction: Irelands Cystic Fibrosis (CF) newborn screening programme is due to commence later in 2011 using immune reactive trypsinogen & genetic analysis for the detection of cystic fibrosis transmembrane regulator protein (CFTR) mutations. The National Centre for Medical Genetics screens for 11 CFTR mutations & further analysis for rarer mutations is currently performed in Manchester (using gene sequencing & multiplex ligation-dependant probe amplification (MLPA) testing). Prior to 2008 this further analysis was performed in Exeter & subsequently in Brest.. Aim: To identify the turn-around time for genetic analysis results for children with suspected CF. Methods: A 16 year retrospective study of genetic analysis results for CFTR mutations was performed. The turn-around time was defined as the number of days from sending DNA until reports were received. Descriptive statistics were used.. Results: Overall, the median time to receive genetic analysis results was 23 days, range 1-2434 days ...
Multidrug-resistant tuberculosis (MDR-TB) is an increasing global problem. Meta-analysis by Orenstein et al. about treatment outcome of MDR TB worldwide was: 62% successful, 11% death and 12% defaulted. Report by Chiang et al. about treatment without DOTS-Plus showed an outcome for 299 MDR-TB patients in Taiwan as follows: 51.2% treatment success, 9.4% died, and 29.1% defaulted.. Our aim was to assess treatment outcome of MDR-TB patients after introduction of "DOTS-Plus strategy" in Eastern Taiwan, following WHO guidelines.. We reviewed all patients who began treatment with DOTS-Plus for MDR-TB in Eastern Taiwan, between May 1st, 2007 and November 30th, 2012.. Out of a total of 135 bacteriologically confirmed MDR-TB cases, 13 were still in treatment. Among 122 patients with final outcomes, 54 (44.26%) were new cases, 47 (38.52%) have been previously treated with first line anti-TB drugs, 21 (17.21%) with secondary second line drugs. The mean age was 49.7 years (range 12 to 93) and 94 (77.05%) ...
Now for the primary question: Non pregnant hypertensives are often classified as having volume dependent or independent hypertension, the former obviously better controlled with sodium restriction and diuretics. For this reason the NHBP working group gave physicians the option of continuing the use of a diuretic in chronic hypertensives who conceive when such therapy had been an important constituent of nonpregnant control. This patient’s statement of how good her control is now is an obvious hint that she has a volume component to her high blood pressure. Also, when chronic hypertensives loose control during pregnancy, adding a diuretic (carefully) is often more successful than other second line drugs, especially in diabetics, and personal experience has seen this approach prolong pregnancy to viability, especially in these diabetics with both high blood pressure and some edema. The thiazide diuretics are perhaps those with the largest history of pregnancy ...
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Molecular interaction between nucleic acid bases and amino acids is a fundamental process in biology. The adsorption of the molecules on surfaces provides the opportunity to study such interactions in great detail by exploiting the high-resolution imaging capabilities of scanning tunnelling microscopy (STM). The chemisorption of prochiral molecules, such as adenine, on a metal surface causes the adsorbed species to become chiral1. Subsequent interactions with inherently chiral molecules may then lead to the formation of diastereoisomers, if the enantiomeric interaction process is sufficiently strong. In the case of adenine adsorption on Cu{110}, the chiral adsorbates form homochiral chains. Here, we show that the adenine chain direction is fully correlated with the chirality, and that the α-amino acid, phenylglycine, shows a strong chiral preference in its interaction with these chains. STM images clearly demonstrate that S-phenylglycine (R-phenylglycine) binds only to chains rotated 19.5° ...
By Aaron Rowe June 27, 2007 A recent article in the Journal of Emergency Medicine tells the story of a 20-year-old kid from Portland, Oregon that extracted the active ingredient,...
The CLIA Waived QuikScreen Multiple Drug Test Cup does not require any handling or manipulation to activate the test. Just dispense urine into the cup and read the results. The cup does all the work in only 5 minutes. This easy to use urinalysis drug test cup detects drugs and drug metabolites at SAMHSA cutoff levels. ...
SPE Supra-Clean MM1 (Mixed-Mode) Column, 200 mg/15 mL is recommended for extracting basic compounds when analyzing drugs and drug metabolites.
TY - JOUR. T1 - Regulation of cholangiocyte secretion. AU - Fitz, J. Gregory. PY - 2002/8. Y1 - 2002/8. N2 - Observations from a variety of model systems suggest that ductular bile formation is mediated in large part by transepithelial transport of Cl- ions and have identified Cl- channels in the apical membrane as important targets for hormones and other factors that modulate bile volume and composition through effects on duct cells. Signaling through secretin receptors that stimulate adenylyl cyclase and activate the cystic fibrosis transmembrane regulator (CFTR) Cl- channels represents a prototype for cholangiocyte secretion. However, recent observations indicate that cholangiocytes also express a variety of receptors that modulate secretory responses in the absence of effects on cyclic adenosine monophosphate (cAMP), and Cl- channels unrelated to CFTR have been identified. Moreover, rapid exocytosis of subapical vesicles is coupled closely to different Cl- secretory responses. These ...
XDR Tuberculosis, or extensively drug resistant TB, doesnt respond to any of the first-line drugs nor 3 of the 6 second line drugs, making it very evasive of our current medical arsenal. We arent facing a disease as dangerous as the subject of the film Outbreak, but there is concern. TB is spread through droplets in the air, which only reach those in close proximity, and only active TB infections are spread by coughing. Moreover, you need a high dose of the bacteria in order to get a productive infection; just a few mycobacteria will be non-infectious to nearly any normal host. This TB scare is not frightening because of its ability to spread rapidly or its high host fatality, but rather because modern medicine isnt equipped to deal with large numbers of cases of this disease ...
We have reported the largest randomised controlled trial of a mucoactive therapy in non-CF bronchiectasis to date. We found that the annual exacerbation rate was reduced in both the high dose (400 mg twice daily) and low dose (50 mg twice daily) control arms during the course of the study, although there was no difference in annual exacerbation rate between the two arms. However, inhaled mannitol at a dose of 400 mg twice daily significantly extended the time to first exacerbation, increased the proportion of patients who remained exacerbation free, reduced the number of days of antibiotic therapy and improved quality of life.. Although the study cohort was intentionally enriched for a subset of adults with bronchiectasis having a significant impact on their lives, including having at least two exacerbations in the previous 12 months, a minimum SGRQ score of 30, producing at least 10 grams of sputum a day and an FEV1 ,85% predicted, the population studied is arguably representative of many ...
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To determine whether a primary MNV-1 infection induces protection against a secondary challenge, we infected 129SvEv mice with 104 PFU MNV-1 and then rechallenged them with 107 PFU MNV-1 6 weeks later. The incidence of fecal inconsistency in mice receiving a secondary 107-PFU infection was similar to that in mice receiving a primary 107-PFU infection (Fig. 3A). We conclude that a primary high-dose MNV-1 infection does not elicit protection against disease upon rechallenge with a homologous virus. To begin dissecting the underlying cause of the lack of protection against MNV-1-induced disease, we tested whether virus loads in rechallenged mice differed from those in mice receiving a primary infection at 48 hpi, a time at which high levels of virus were observed during primary infection. There was a significant decrease in virus loads in the intestines and a complete absence of infectious virions in the spleens of previously exposed 129SvEv mice (Fig. 3B, black bars). Surprisingly, though (based ...
Resistance to drugs generally results from the overuse of antibiotics. Its simple evolution, really. Few of a population of TB germs may develop a genetic factor enabling it to resist a drug administered on the patient, say drug A. These few are the only surviving members of the population. Now, these multiply, giving rise to the next generation of germs resistant to this particular drug. When it infects another patient, a new drug - say drug B - is needed. Some members of this new population can then develop resistance to drug B, while retaining its resistance to drug A. Over prescription of medicines known to work on TB germs accelerates this process and very soon we get TB germs resistant to multiple drugs. This is what is referred to as Multi-Drug Resistant TB (MDR-TB).. TDR-TB refers to TB which are resistant to first line drugs. First line drugs are drugs proven to work against the bacteria, with the least amount of side-effects. There is a second line, which may not be as effective, or ...
The N-acetyl derivative of CYSTEINE. It is used as a mucolytic agent to reduce the viscosity of mucous secretions. It has also been shown to have antiviral effects in patients with HIV due to inhibition of viral stimulation by reactive oxygen intermediates. . ...
Mucoslovan, also known by its generic name of ambroxol hydrochloride, can cause mild gastrointestinal problems occasionally in some people, according to Drugs.com. Known as a mucolytic agent, this...
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Acetylcysteine 20% is a medicine available in a number of countries worldwide. A list of US medications equivalent to Acetylcysteine 20% is available on the Drugs.com website.
A procedure called autoinflation involves a child blowing up a small balloon using a plastic tube that is inserted into their nose. More about the procedure here.
SPE Supra-Clean® Columns C18-S 200 mg/3 mL are recommended for extracting mid-polar to non-polar compounds when analyzing drugs and drug metabolites in biological matrices, trace organic material in water, and toxins in food.
US scientists have created pigs with cystic fibrosis (CF), a breakthrough that should open the door to a raft of research into the fatal condition.. Initial reports from the study, published in the journal Science, suggest that the pig model is manifesting a number of the early markers for the disease: an abnormal pancreas, liver and gall bladder and meconium ileus (an inability to pass faeces in a newborn) - the first animal model to do so, although no abnormal lung function has yet been detected.. CF affects 8000 people in the UK, and is caused by the inheritance of a mutated version of a gene called CFTR (cystic fibrosis transmembrane regulator) that codes for chloride ion channels important in the production of mucus, sweat and digestive juices. Both copies of the CFTR gene must be mutated for the disease to be present. Prolonged inappropriate production of these vital secretions leads to poor growth, recurrent lung inflammation and infection, progressive disability and multi-system ...
Proteins encoded by best1 to -3 genes are implicated as molecular correlates of calcium-activated chloride channels in epithelia. In this issue of Circulation Research, Matchkov et al present compelling evidence that best-3 expression is essential for the generation of calcium-sensitive cGMP-dependent chloride channels in rat mesenteric artery.1. Chloride channels are enigmatic beasts. Numerous phenotypes exist, as determined by their mode of activation, channel kinetics, and pore properties, but the molecular identity has only really been identified for the voltage-dependent Cl− channels (CLCs) and the cAMP-dependent, cystic fibrosis transmembrane regulator (CFTR) channels. For the other types of Cl− channels, there is far less certainty about the molecular identity. Many candidates for the swelling-activated Cl− channel have been promulgated that ultimately have been repudiated.2 Similarly, the molecular identity of the Ca2+-gated Cl− channel, common to vascular smooth muscle cells, ...
ATCC ® Normal Human Primary Bronchial/Tracheal Epithelial Cells, when grown in Airway Epithelial Cell Basal Media supplemented with Bronchial/Tracheal Epithelial Cell Growth Kit components, provide an ideal cell system to propagate bronchial/tracheal epithelial cells in serum-free conditions. The cells are cryopreserved at the second passage to ensure the highest viability and plating efficiency. ATCC ® Primary Cell Solutions™ cells, media, supplements and reagents are quality tested together to guarantee optimum performance and reliability.
A combined theoretical and experimental study of the ionized dimers of thymine and adenine, TT, AA, and AT, is presented. Experimentally observed and computed adiabatic and vertical ionization energies (IEs) for monomers and dimers as well as thresholds for the appearance of the protonated species are report
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Acetylcysteine Solution official prescribing information for healthcare professionals. Includes: indications, dosage, adverse reactions, pharmacology and more.
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Carbocysteine | The Merck Index OnlineCarbocysteine | The Merck Index Online

Carbocysteine , Monograph containing literature references, physical and biological properties and relevant information ...
more infohttps://www.rsc.org/Merck-Index/monograph/m3072?q=unauthorize

Carbocysteine - GanfydCarbocysteine - Ganfyd

This site uses cookies and sets some by default. By continuing to browse the site you are agreeing to our use of cookies. Find out more here ...
more infohttp://www.ganfyd.org/index.php?title=Carbocysteine

Carbocysteine therapy in older people with chronic obstructive pulmonary disease  - Surrey Research Insight Open AccessCarbocysteine therapy in older people with chronic obstructive pulmonary disease - Surrey Research Insight Open Access

Mitchell, SC and Steventon, GB (2006) Carbocysteine therapy in older people with chronic obstructive pulmonary disease JOURNAL ...
more infohttp://epubs.surrey.ac.uk/821207/

Altmetric - Acetylcysteine and carbocysteine for acute upper and lower respiratory tract infections in paediatric patients...Altmetric - Acetylcysteine and carbocysteine for acute upper and lower respiratory tract infections in paediatric patients...

Acetylcysteine and carbocysteine are the most commonly prescribed mucolytic drugs in Brazil and many European and African ... Acetylcysteine and carbocysteine for acute upper and lower respiratory tract infections in paediatric patients without chronic ... Acetylcysteine and carbocysteine for acute upper and lower respiratory tract infections in paediatric patients without chronic ...
more infohttps://www.altmetric.com/details/1801805

Antioxidant activity of carbocysteine lysine salt monohydrate. - COREAntioxidant activity of carbocysteine lysine salt monohydrate. - CORE

Antioxidant activity of carbocysteine lysine salt monohydrate. By PINAMONTI S, VENTUROLI L, LEIS M, CHICCA M, BARBIERI A, ... Carbocysteine lysine salt monohydrate (CLS) is a mucoactive drug effective in the treatment of bronchopulmonary diseases ...
more infohttps://core.ac.uk/display/54676327

China Lincomycin Hydrochloride Syrup (Paracetamol & Ibuprofen & Carbocysteine Syrup) - China Lincomycine, SyrupChina Lincomycin Hydrochloride Syrup (Paracetamol & Ibuprofen & Carbocysteine Syrup) - China Lincomycine, Syrup

Carbocysteine Syrup), Find details about China Lincomycine, Syrup from Lincomycin Hydrochloride Syrup (Paracetamol & Ibuprofen ... Lincomycin Hydrochloride Syrup (Paracetamol & Ibuprofen & Carbocysteine Syrup) Get Latest Price Min. Order / Reference FOB ... Carbocysteine Syrup), Vitamin K3 K1 Injection Vitamin High Quality Sodium Bisulfite Menaquinone, Vitamin K1 3 Injection Vitamin ...
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Publication: Efficacy and tolerability of a polysaccharide-resin-honey based cough syrup as compared to carbocysteine syrup for...Publication: Efficacy and tolerability of a polysaccharide-resin-honey based cough syrup as compared to carbocysteine syrup for...

The objective of this trial is to compare the effects of a polysaccharide-resin-honey based cough syrup, and carbocysteine ... Efficacy and tolerability of a polysaccharide-resin-honey based cough syrup as compared to carbocysteine syrup for children ... Conclusions: Both polysaccharide-resin-honey and carbocysteine cough syrups were well tolerated in children over 2 years of age ... Publication: Efficacy and tolerability of a polysaccharide-resin-honey based cough syrup as compared to carbocysteine syrup for ...
more infohttp://clalitresearch.org/publication-efficacy-and-tolerability-of-a-polysaccharide-resin-honey-based-cough-syrup-as-compared-to-carbocysteine-syrup-for-children-with-colds-a-randomized-single-blinded-multicenter-st/

Bai Yue - Drugs.comBai Yue - Drugs.com

Carbocysteine. Carbocisteine is reported as an ingredient of Bai Yue in the following countries:. *China ...
more infohttps://www.drugs.com/international/bai-yue.html

Casalmux - Drugs.comCasalmux - Drugs.com

Carbocysteine. Carbocisteine is reported as an ingredient of Casalmux in the following countries:. *Vietnam ...
more infohttps://www.drugs.com/international/casalmux.html

Drug Names  Quiz - By penguin limDrug Names Quiz - By penguin lim

Can you name the %$#*@)! Drug Names ? Test your knowledge on this science quiz to see how you do and compare your score to others. Quiz by penguin_lim
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Human Metabolome Database: Showing metabocard for L-Cysteine (HMDB0000574)Human Metabolome Database: Showing metabocard for L-Cysteine (HMDB0000574)

Cysteine is a naturally occurring, sulfur-containing amino acid that is found in most proteins, although only in small quantities. Cysteine is unique amongst the twenty natural amino acids as it contains a thiol group. Thiol groups can undergo oxidation/reduction (redox) reactions; when cysteine is oxidized it can form cystine, which is two cysteine residues joined by a disulfide bond. This reaction is reversible since the reduction of this disulphide bond regenerates two cysteine molecules. The disulphide bonds of cystine are crucial to defining the structures of many proteins. Cysteine is often involved in electron-transfer reactions, and help the enzyme catalyze its reaction. Cysteine is also part of the antioxidant glutathione. N-Acetyl-L-cysteine (NAC) is a form of cysteine where an acetyl group is attached to cysteines nitrogen atom and is sold as a dietary supplement. Cysteine is named after cystine, which comes from the Greek word kustis meaning bladder (cystine was first isolated from ...
more infohttp://www.hmdb.ca/metabolites/HMDB0000574

Murhinol (Carbocisteine) Farmaline, ThailandMurhinol (Carbocisteine) Farmaline, Thailand

Syrup; Oral; Carbocysteine 100 mg / 5 ml*Syrup; Oral; Carbocysteine 250 mg / 5 ml*Tablets; Oral; Carbocysteine 375 mg. ...
more infohttp://drugs-about.com/drugs-m/murhinol.html

Niquitin Application Site Erythema Side EffectsNiquitin Application Site Erythema Side Effects

Carbocysteine. *Dexibuprofen. When commencing Niquitin Cq 21mg, the patient experienced the following unwanted symptoms /side ...
more infohttp://patientsville.com/niquitin/application-site-erythema.htm

Iressa Side EffectsIressa Side Effects

Carbocysteine. *. Clopidogrel. *. Enoxaparin. *. Ferrous Sulfate Tab. *. Folic Acid. and developed a serious reaction and side ...
more infohttp://patientsville.com/medication/iressa_side_effects.htm

PPT - RESPIRATORY DRUGS PowerPoint Presentation - ID:387502PPT - RESPIRATORY DRUGS PowerPoint Presentation - ID:387502

2. Carbocysteine (SCMC) - act by regulating and normalizing the viscosity of secretion from the mucus cell of respiratory tract ...
more infohttps://www.slideserve.com/kort/respiratory-drugs

Mucolytic Actithiol Antihistamine Oral solutionMucolytic Actithiol Antihistamine Oral solution

Antihistamine Mucolytic Actithiol contains carbocysteine and promethazine.. Carbocysteine is a mucolytic that liquefies and ... Carbocysteine / Promethazine hydrochloride. What is Actithiol Mucolytic Antihistamine and what it is used. ...
more infohttp://www.farmacia-internacional.net/en/medicines/14845-mucolytic-actithiol-antihistamine-oral-solution-200ml-8470007012849.html

Mucoactive drugs | European Respiratory SocietyMucoactive drugs | European Respiratory Society

Carbocysteine. Metabolism of mucus producing cells, antioxidant and anti-inflammatory effects, modulates mucus production. ...
more infohttps://err.ersjournals.com/content/19/116/127.figures-only
  • Lincomycine, Syrup, Lincomycin Syrup manufacturer / supplier in China, offering Lincomycin Hydrochloride Syrup (Paracetamol & Ibuprofen & Carbocysteine Syrup), Vitamin K3 K1 Injection Vitamin High Quality Sodium Bisulfite Menaquinone, Vitamin K1 3 Injection Vitamin High Quality Sodium Bisulfite Menaquinone and so on. (made-in-china.com)
  • The objective of this trial is to compare the effects of a polysaccharide-resin-honey based cough syrup, and carbocysteine syrups on nocturnal and daytime cough associated with childhood upper respiratory tract infections (URIs). (clalitresearch.org)
  • Using Kebelo pioneered carbocysteine hair technology that allow the treatment to support, strengthen and revitalise each strand from within, weak, dull, frizzy, unhealthy hair is transformed to beautiful smooth locks filled with bounce and volume. (secrets-salon.co.uk)
  • Formulated with the latest Carbocysteine and Dispersion Technology, infused with botanical proteins and amino acids, it is the most advanced formula available. (haircrafthelensburgh.com)
  • CTS with an experience of over 9 decades leading in Pharmaceuticals & Derma-cosmetics product line with focused within Healthcare, Animal Care & Agriculture sectors intends to cater niche and under developed market of Carbocysteine (mucolytic) through a comprehensive solution offering 4 different forms of administration - 2 of them are new to the Indian market (Pediatric & lozenges). (skyquestt.com)
  • Ampolla/ Vial 2 (Sellador de Cuticula y regenerativa): Water, propyleneglycol -PPG-3 benzyl ether miristate, cyclomethicone, hidrolized wheat protein (and) methicone (and) polyquaternium -10 (and) carbocysteine, glycerin -butyleneglycol-untica diosica -nettle extract ,magnolia biondi flower extract ,imidiazoline urea ,blue#1 and yellow #5 FD+C. (elennox.com)
  • Carbocysteine is the most used amino acid in this kind of treatments, and it works by reducing bridges of keratin hair and changing it from curly to straight. (brasilybelleza.com)