Carbimazole
Antithyroid Agents
Thyrotoxicosis
A hypermetabolic syndrome caused by excess THYROID HORMONES which may come from endogenous or exogenous sources. The endogenous source of hormone may be thyroid HYPERPLASIA; THYROID NEOPLASMS; or hormone-producing extrathyroidal tissue. Thyrotoxicosis is characterized by NERVOUSNESS; TACHYCARDIA; FATIGUE; WEIGHT LOSS; heat intolerance; and excessive SWEATING.
Hyperthyroidism
Graves Disease
A common form of hyperthyroidism with a diffuse hyperplastic GOITER. It is an autoimmune disorder that produces antibodies against the THYROID STIMULATING HORMONE RECEPTOR. These autoantibodies activate the TSH receptor, thereby stimulating the THYROID GLAND and hypersecretion of THYROID HORMONES. These autoantibodies can also affect the eyes (GRAVES OPHTHALMOPATHY) and the skin (Graves dermopathy).
Methimazole
Propylthiouracil
Thyroxine
The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.
Erythema Nodosum
An erythematous eruption commonly associated with drug reactions or infection and characterized by inflammatory nodules that are usually tender, multiple, and bilateral. These nodules are located predominantly on the shins with less common occurrence on the thighs and forearms. They undergo characteristic color changes ending in temporary bruise-like areas. This condition usually subsides in 3-6 weeks without scarring or atrophy.
Thyroid Gland
A highly vascularized endocrine gland consisting of two lobes joined by a thin band of tissue with one lobe on each side of the TRACHEA. It secretes THYROID HORMONES from the follicular cells and CALCITONIN from the parafollicular cells thereby regulating METABOLISM and CALCIUM level in blood, respectively.
Neuroma, Acoustic
A benign SCHWANNOMA of the eighth cranial nerve (VESTIBULOCOCHLEAR NERVE), mostly arising from the vestibular branch (VESTIBULAR NERVE) during the fifth or sixth decade of life. Clinical manifestations include HEARING LOSS; HEADACHE; VERTIGO; TINNITUS; and FACIAL PAIN. Bilateral acoustic neuromas are associated with NEUROFIBROMATOSIS 2. (From Adams et al., Principles of Neurology, 6th ed, p673)
Audiometry
The testing of the acuity of the sense of hearing to determine the thresholds of the lowest intensity levels at which an individual can hear a set of tones. The frequencies between 125 and 8000 Hz are used to test air conduction thresholds and the frequencies between 250 and 4000 Hz are used to test bone conduction thresholds.
Imidazoline Receptors
Delayed-Action Preparations
Hypothyroidism
Cholestasis, Intrahepatic
Exophthalmos
Choanal Atresia
Coloboma
Pharmacogenetics
Pharmacists
Diabetic ketoacidosis precipitated by thyrotoxicosis. (1/89)
We report two patients with type 1 diabetes mellitus, previously well controlled with good compliance, presenting with unexplained diabetic ketoacidosis. Following initial correction of the metabolic disorder, persisting tachycardia lead to the diagnosis of thyrotoxicosis. In both cases, treatment with propranolol and carbimazole helped in the stabilization of their metabolic states. Although thyrotoxicosis is known to destabilize diabetes control, we can find no reports of it precipitating diabetic ketoacidosis. (+info)Insulin autoimmune syndrome: a rare cause of hypoglycaemia not to be overlooked. (2/89)
We report the case of a Caucasian patient with insulin autoimmune syndrome (IAS), defined as the association of hypoglycaemic attacks with insulin autoantibodies in individuals not previously treated with exogenous insulin. This rare syndrome (more than 200 published cases) has been reported mainly in Japan. Most affected patients present with other autoimmune disorders, most often Graves' disease. In most cases, insulin autoantibodies appear a few weeks after the beginning of treatment with a drug containing a sulphyldryl group. A significant increase in insulin and C-peptide plasma concentrations and the presence of other antiorgan antibodies are observed. The susceptibility haplotype is present in the Japanese population, which may account for the high frequency of IAS. Spontaneous remission is observed in 80% of cases, with cessation of hypoglycaemic attacks and disappearance of insulin autoantibodies some months after withdrawal of the drug. This rare cause of hypoglycaemia in Caucasian subjects should be considered in aetiologic investigation of spontaneous hypoglycaemia. (+info)Prevalence of positive anti-neutrophil cytoplasmic antibody (ANCA) in patients receiving anti-thyroid medication. (3/89)
OBJECTIVE: Vasculitis is a rare complication of anti-thyroid medications. There are 32 cases of anti-neutrophil cytoplasmic antibody (ANCA)-positive vasculitis in association with anti-thyroid medication reported in the English literature. The objectives of this study were to assess the frequency of positive ANCA in patients on long-term anti-thyroid medication, and to follow patients prospectively from commencement of medication to determine whether they became ANCA-positive after therapy. DESIGN: Prospectively collected cross-sectional study of two groups of patients: (i) who had received long-term (>18 months) anti-thyroid medication, and (ii) newly diagnosed thyrotoxicosis before commencement of anti-thyroid medication attending clinic between 28 April 1998 and 30 September 1998. Data were collected for age, sex, ethnicity, underlying thyroid disease, medication and duration, and symptomatology. RESULTS: Eight of 30 patients on long-term anti-thyroid medication (26.7%) were ANCA-positive. All ANCA-positive patients were female, seven were taking propylthiouracil (PTU) at the time of testing. ANCA-positive patients had taken PTU for a mean +/- s.d. of 7.9+/-10.2 years, compared with 0.8+/-2.2 years in ANCA-negative patients (Mann-Whitney, P<0.0001). The ten patients with newly diagnosed thyrotoxicosis were ANCA-negative before commencement of carbimazole. One (10%) became ANCA-positive within 8 months of therapy. CONCLUSIONS: In our population, ANCA-positivity in association with long-term anti-thyroid medication is common (26.7%). One patient who was ANCA-negative prior to anti-thyroid therapy has become ANCA-positive. ANCA should be tested in patients receiving long-term anti-thyroid medications, and in patients with adverse reactions. As PTU is more commonly associated with vasculitis and positive ANCA, carbimazole may be the preferred medication for long-term use. Patients with positive ANCA should be followed, and considered for definitive anti-thyroid therapy, to allow cessation of medication. ANCA-positivity may resolve after cessation of anti-thyroid medication. (+info)Platelet endothelial cell adhesion molecule-1 (PECAM-1) is a target glycoprotein in drug-induced thrombocytopenia. (4/89)
Drug-induced immune thrombocytopenia (DITP) is a serious complication of drug treatment. Previous studies demonstrated that most drug-dependent antibodies (DDAbs) react with the platelet membrane glycoprotein (GP) complexes IIb/IIIa and Ib/IX/V. We analyzed the sera from 5 patients who presented with DITP after intake of carbimazole. Notably, thrombocytopenia induced by carbimazole was relatively mild in comparison to patients with DITP induced by quinidine. The sera reacted with platelets in an immunoassay on addition of the drug. In immunoprecipitation experiments with biotin-labeled platelets and endothelial cells, reactivity with the platelet endothelial cell adhesion molecule-1 (PECAM-1, CD31) could be demonstrated, whereas neither GPIIb/IIIa nor GPIb/IX was precipitated in the presence of the drug. These results could be confirmed by GP-specific immunoassay (MAIPA) using monoclonal antibodies (mabs) against PECAM-1. In addition, the binding of DDAbs could be abolished by preincubation with soluble recombinant PECAM-1. Carbimazole-dependent antibodies showed similar reactivity with platelets carrying the Leu(125) and Val(125) PECAM-1 isoforms, indicating that this polymorphic structure, which is located in the first extracellular domain, is not responsible for the epitope formation. Binding studies with biotin-labeled mutants of PECAM-1 and analysis of sera with mabs against different epitopes on PECAM-1 in MAIPA assay suggested that carbimazole-dependent antibodies prominently bound to the second immunoglobulin homology domain of the molecule. Analysis of 20 sera from patients with quinidine-induced thrombocytopenia by MAIPA assay revealed evidence that DDAbs against PECAM-1 are involved in addition to anti-GPIb/IX and anti-GPIIb/IIIa. We conclude that PECAM-1 is an important target GP in DITP. (Blood. 2000;96:1409-1414) (+info)Successful treatment of amiodarone-induced thyrotoxicosis. (5/89)
BACKGROUND: Amiodarone-induced thyrotoxicosis (AIT) is a difficult management problem about which there are little published data. We examined whether continuing amiodarone or differentiating AIT into 2 subtypes affected outcome. METHODS AND RESULTS: The type and duration of antithyroid treatment and response were recorded in a consecutive series of 28 cases. Comparisons were made between those in whom amiodarone either was continued or stopped and between those with either possible type 1 or type 2 AIT. Of the 28 cases, 5 had spontaneous resolution of AIT; 23 received carbimazole (CBZ) alone as first-line therapy. Eleven achieved long-term euthyroidism off CBZ or on a maintenance dose. Five became hypothyroid and required long-term thyroxine. Five relapsed after stopping CBZ treatment and were rendered euthyroid with either long-term CBZ (n=3) or radioiodine (n=2). Four were intolerant of CBZ and received propylthiouracil (PTU), with good effect in 3. One was resistant to thionamide alone (CBZ then PTU) and responded to adjunctive steroids. No difference in presentation or outcome was noted between those in whom amiodarone was continued or stopped or between possible type 1 or type 2 AIT. CONCLUSIONS: Continuing amiodarone has no adverse influence on response to treatment of AIT. First-line therapy with a thionamide alone is appropriate in iodine-replete areas, thus avoiding potential complications of other drugs. Differentiating between 2 possible types of AIT does not influence management or outcome. (+info)Jaundice due to carbimazole. (6/89)
On three occasions, a 63 year old housewife with hyperthyroidism developed a reaction which included fever, pruritus, malaise, and, on one occasion, jaundice one to 17 days after taking carbimazole. Challenge with carbimazole was followed within 12 hours by abdominal pain, pruritus, and increased serum transaminase levels. Light microscopy of a liver biopsy showed increase of portal zone cellularity over the control and the electron microscopy revealed fine structural changes compatible with drug-related liver injury. (+info)The influence of preoperative drug treatment on the extent of hyperplasia of the thymus in primary thyrotoxicosis. (7/89)
Thymic biopsies taken from women at the beginning of the operation of subtotal thyroidectomy were studied by the point-counting histometric technique. In all patients with primary thyrotoxicosis, the thymus is hyperplastic. After pretreatment with antithyroid drugs, the pattern of thymic involution with age is similar to, but at higher levels, than that in control groups of patients with non-toxic goitre in whom there is no evidence of immunological abnormality. By contrast, after propranolol pretreatment very little age involution is seen. The differences in the appearance of the thymus in female primary thyrotoxixosis patients prepared for operation with different drug treatment regimes are probably related to the pharmacological actions of the drugs and may indicate an interaction between primary immunological and secondary endocrinological factors in the disease process. (+info)Acute pancreatitis, hepatic cholestasis, and erythema nodosum induced by carbimazole treatment for Graves' disease. (8/89)
A 33-year old female was diagnosed as Graves' disease and started on carbimazole. One month later when she was already euthyroid only on carbimazole therapy, she developed acute pancreatitis associated with mild cholestatic hepatitis and erythema nodosum. Carbimazole therapy was interrupted, pancreatic and liver function gradually improved and became normalized two weeks later. Other potential etiological causes of acute pancreatitis, hepatitis and erythema nodosum were excluded. Rechallenge with a single dose of carbimazole led to a new episode of acute pancreatitis and cholestatic hepatitis one day later. The appearance of different hypersensitivity reactions including pancreatitis, hepatitis and erythema nodosum, together with the observation that the interval between drug intake and onset of symptoms became shorter with repeated exposure to carbimazole, point to an immune-mediated mechanism. Carbimazole has to be added to the list of drugs capable of inducing acute pancreatitis, and should be emphasized the need to discontinue this medication as soon as there is evidence of pancreatic dysfunction. (+info)
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Hyperthyroidism
Carbimazole is only available as a once daily tablet. Methimazole is available as an oral solution, a tablet, and compounded as ... Drugs used to help manage the symptoms of hyperthyroidism are methimazole and carbimazole. Drug therapy is the least expensive ... Thyrostatics (antithyroid drugs) are drugs that inhibit the production of thyroid hormones, such as carbimazole (used in the UK ...
WHO Model List of Essential Medicines
Carbimazole is an alternative depending on local availability *^ For use when alternative first-line treatment is not ... Carbimazole is an alternative depending on local availability *^ For use when alternative first-line treatment is not ...
Aplasia cutis congenita
It can also seen with exposure to methimazole and carbimazole in utero. This dermatological manifestation has been linked to ...
Thioamide
Members of the thioamide group include methimazole, carbimazole (converted in vivo to methimazole), and propylthiouracil. ...
Graves' disease
The main antithyroid drugs are carbimazole (in the UK), methimazole (in the US), and propylthiouracil/PTU. These drugs block ...
Antithyroid agent
The main antithyroid drugs are carbimazole (in the UK), methimazole (in the US), and propylthiouracil/PTU. A less common ...
Thyroid
... carbimazole and methimazole. Alternatively, radioactive iodine-131 can be used to destroy thyroid tissue: radioactive iodine is ...
Insulin autoimmune syndrome
However, interaction of disulfide bond in the insulin molecule with sulfhydryl group drugs such as methimazole, carbimazole, ... "Insulin autoimmune syndrome as a cause of recurrent hypoglycemia in a carbimazole user: a case report from Nepal". ... "Insulin autoimmune syndrome as a cause of recurrent hypoglycemia in a carbimazole user: a case report from Nepal". ...
Thyroid disease in pregnancy
... is recommended but this should be changed back to carbimazole after the first trimester. This is because carbimazole can rarely ... Carbimazole and PTU are both secreted in breast milk but evidence suggests that antithyroid drugs are safe during lactation. ... If a woman is already receiving carbimazole, a change to propylthiouracil (PTU) ...
Amastia
... causes may include intra-uterine exposure to teratogenic drugs such as dehydroipiandrosterone and methiamozole/carbimazole ...
Thyroid disease
Hyperthyroidism caused by Graves' disease may be treated with the thioamide drugs propylthiouracil, carbimazole or methimazole ...
WHO Model List of Essential Medicines for Children
In acute diarrhoea zinc sulfate should be used as an adjunct to oral rehydration salts carbimazole is an alternative depending ...
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List of MeSH codes (D03)
... carbimazole MeSH D03.383.129.308.130 - cimetidine MeSH D03.383.129.308.175 - clotrimazole MeSH D03.383.129.308.207 - creatinine ...
WHO Model List of Essential Medicines
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List of drugs: C-Ca
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ATC code H03
Thyroid gland preparations H03BA01 Methylthiouracil H03BA02 Propylthiouracil H03BA03 Benzylthiouracil H03BB01 Carbimazole ...
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The molecular formula C7H10N2O2S may refer to: Carbimazole, drug used to treat hyperthyroidism Mafenide, a sulfonamide-type ...
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Levothyroxine
... is typically used to treat hypothyroidism,[9] and is the treatment of choice for people with hypothyroidism,[10] who often require lifelong thyroid hormone therapy.[11] It may also be used to treat goiter via its ability to lower thyroid-stimulating hormone (TSH), a hormone that is considered goiter-inducing.[12][13] Levothyroxine is also used as interventional therapy in people with nodular thyroid disease or thyroid cancer to suppress thyroid-stimulating hormone (TSH) secretion.[14] A subset of people with hypothyroidism treated with an appropriate dose of levothyroxine will describe continuing symptoms despite TSH levels in the normal range.[11] In these people, further laboratory and clinical evaluation is warranted as they may have another cause for their symptoms.[11] Furthermore, it is important to review their medications and possible dietary supplements as several medications can affect thyroid hormone levels.[11] Levothyroxine is also used to treat subclinical ...
Iodine-131
... (131I, I-131) is an important radioisotope of iodine discovered by Glenn Seaborg and John Livingood in 1938 at the University of California, Berkeley.[1] It has a radioactive decay half-life of about eight days. It is associated with nuclear energy, medical diagnostic and treatment procedures, and natural gas production. It also plays a major role as a radioactive isotope present in nuclear fission products, and was a significant contributor to the health hazards from open-air atomic bomb testing in the 1950s, and from the Chernobyl disaster, as well as being a large fraction of the contamination hazard in the first weeks in the Fukushima nuclear crisis. This is because 131I is a major fission product of uranium and plutonium, comprising nearly 3% of the total products of fission (by weight). See fission product yield for a comparison with other radioactive fission products. 131I is also a major fission product of uranium-233, produced from thorium. Due to its mode of beta decay, ...
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The earliest oral treatment for hypothyroidism consisted of thyroid extract. George Redmayne Murray of the United Kingdom first described treatment of myxedema with thyroid extract in 1891, and published a description of long-term successful treatment (28 years) of a patient with myxedema (severe hypothyroidism) in 1920[17] His treatment was quickly adopted in North America and Europe. The first recorded American use dates to 1891 by a woman who was still taking it 52 years later at 84 years of age [18] Desiccated thyroid extract is prepared from pig thyroid glands. The glands are dried (desiccated), ground to powder, combined with binder chemicals, and pressed into pills. This was a new use for parts that were previously unwanted slaughterhouse offal, and Armour and Company, the dominant American meatpacker in the 20th century, supplied the best-known brand of thyroid extract.[citation needed] Replacement by thyroid extract in hypothyroidism was one of the most effective treatments of any ...
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Thyroid
Long-term management of hyperthyroidism may include drugs that suppress thyroid function such as propylthiouracil, carbimazole ...
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Carbimazole-induced acute cholestatic hepatitis in patient with Graves disease. MS Rathi & EG Ward. ... Thyrostatic medications (carbimazole or propylthiouracil) as first line therapy to treat hyperthyroidism can rarely cause ... We report a patient who developed cholestatic jaundice after carbimazole therapy.. Case report: A 32-year-old woman presented ... Liver function test showed ALT 120 IU/l (,40), ALP 750 iu/l (70 300). Drug induced hepatitis was suspected hence carbimazole ...
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Reported more in propylthHyperthyroidismMethimazoleTabletsThyrotoxicosisGravesTabletTake carbimazoleAgranulocytosisThiamazolePatients treated with carbimazoleMedicationDoseLevothyroxineNeomercazoleCheap CarbimazolePurchase carbimazolePropranololProduction of thyroid hormonesThyroxineAntithyroid drugTreatmentANCAHepatitis was suspeSeleniumImidazole derivativesTherapyEuthyroidThyrocabMedicinesHyperthyroid cats40mgCholestasisHypersensitivityPatientPrescriptionDrugSupplierPriceSepsisSore throatRarelyEfficacy
Reported more in propylth1
- Vasculitis is uncommon, but ANCA positivity is reported more in propylthiouracil and rarely with carbimazole or methimazole (1). (thefreedictionary.com)
Hyperthyroidism15
- Carbimazole is used to treat hyperthyroidism. (wikipedia.org)
- She had been on tablets propranolol and carbimazole for hyperthyroidism. (thefreedictionary.com)
- Effective treatment options for hyperthyroidism, as you have alluded to, include methimazole or carbimazole administration, radioiodine therapy, surgical removal of the thyroid gland, and perhaps restriction of dietary iodine. (thefreedictionary.com)
- Evaluation of efficacy and safety of a novel controlled-release formulation of carbimazole in feline hyperthyroidism. (wiley.com)
- Thyrostatic medications (carbimazole or propylthiouracil) as first line therapy to treat hyperthyroidism can rarely cause potentially fatal hepatotoxicity. (endocrine-abstracts.org)
- OBJECTIVE: To determine the spectrum of clinical presentations of hyperthyroidism in cats and response to carbimazole therapy by analysis of historical, clinical and laboratory data. (avmi.net)
- Carbimazole is used to treat an overactive thyroid gland (hyperthyroidism). (patient.info)
- Antithyroid medicines like carbimazole are used to treat an overactive thyroid gland (hyperthyroidism) , which is also known as thyrotoxicosis. (patient.info)
- Carbimazole is the most commonly used medicine for hyperthyroidism. (patient.info)
- Carbimazole may be used alone or together with other treatments for hyperthyroidism. (patient.info)
- Carbimazole is used in the treatment of hyperthyroidism. (rivergirls.nl)
- Carbimazole (brand names include: Neomercazole / Vidalta / Camazol) is used for treating hyperthyroidism. (thehealthguard.net)
- Weight homeostasis & its modulators in hyperthyroidism before & after treatment with carbimazole. (bvsalud.org)
- Patients with hyperthyroidism predominantly had decreased lean body mass which increased after achievement of euthyroidism with carbimazole . (bvsalud.org)
- Luckily, after elimination of hyperthyroidism and concomitant symptoms with drug therapy, which may include an anti-thyroid agent for reducing the production of thyroid hormones, such as carbimazole capsules which were created on the basis of an individual dosage form, arrhythmia can be completely cured. (mentalitch.com)
Methimazole8
- Carbimazole is a pro-drug as after absorption it is converted to the active form, methimazole. (wikipedia.org)
- In this case, the treatment entails intake of medicines such as: methimazole or carbimazole , or in other cases radioactive iodine treatment to ablate the gland, or even surgery. (thefreedictionary.com)
- Similarly methimazole or carbimazole , which are safe anti thyroid drugs, are not included. (thefreedictionary.com)
- Carbimazole is a pro-drug of methimazole that is an inhibitor of thyroid enzyme thyroperoxidase. (sigmaaldrich.com)
- In the present study we have demonstrated that carbimazole is rapidly converted to methimazole in vitro by serum from rats and humans, and we have obtained evidence that this conversion is enzymatic. (avmi.net)
- Carbimazole is rapidly metabolised to methimazole. (mims.com)
- The mean peak plasma concentration of methimazole is reported to occur one hour after a single dose of carbimazole. (mims.com)
- Carbimazole is metabolized to METHIMAZOLE, which is responsible for the antithyroid activity. (nih.gov)
Tablets7
- Once daily administration of controlled-release carbimazole tablets was effective and had expected tolerance in hyperthyroid cats during short- and long-term treatment. (wiley.com)
- Alternatively, after 4-8 weeks, you may be prescribed a medicine called levothyroxine to take in addition to the carbimazole tablets which you are already taking. (patient.info)
- Surat, Gujarat, 306, Shubh Square Lal Darwaja, Surat - 395003, Dist. Carbimazole 5mg Tablets - Patient Information Leaflet (PIL) by Accord-UK Ltd ALWAYS READ THE LABEL. (rivergirls.nl)
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- Carbimazole Tablets are used to reduce the formation of thyroid hormones in animals with an overactive thyroid gland. (hillsidevets.com.sg)
- I am feeding cats whilst owner is on holiday and the carbimazole tablets were pushed inside treats and the cats pulled lid of plastic box. (justanswer.co.uk)
- Keeping in mind the diverse requirements of the clients, we offer our clients wide range of Carbin 5 Tablets (Carbimazole). (medicoremediesindia.net)
Thyrotoxicosis4
- Graves thyrotoxicosis was diagnosed and carbimazole 40 mg a day was initiated. (endocrine-abstracts.org)
- Leicester Research Archive: Choanal atresia: the result of maternal thyrotoxicosis or fetal carbimazole? (le.ac.uk)
- Choanal atresia: the result of maternal thyrotoxicosis or fetal carbimazole? (le.ac.uk)
- We describe a patient who was admitted with uncontrolled thyrotoxicosis and carbimazole induced neutropenia. (edu.pl)
Graves8
- Effect of carbimazole treatment on specific and non-specific immunological parameters in patients with Graves' disease. (thefreedictionary.com)
- We present a previously undocumented complication of carbimazole treatment occurring in a 28 year old woman with Graves' disease. (bmj.com)
- Does Carbimazole slow down Graves disease? (endocrineweb.com)
- If I take 40mg of Carbimazole a day (which my doctor has subscribed to send me hypo), and I go Hypothyroid will this stop the Graves disease or slow it down? (endocrineweb.com)
- My doctor is planning to put me on joint, Carbimazole and Levothyroxine to level out my thyroid levels, will the Levothyroxine make my Graves disease worse? (endocrineweb.com)
- Carbimazole (CBZ) is one of the major drugs currently used for the treatment of Graves' disease. (avmi.net)
- Propylthiouracil and carbimazole associated-antineutrophil cytoplasmic antibodies (ANCA) in patients with Graves' disease. (ox.ac.uk)
- Furthermore, within the Graves' disease population, ANCA development was associated with propylthiouracil usage to a greater extent than carbimazole. (ox.ac.uk)
Tablet2
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- Each NeoMercazole 5 tablet contains carbimazole Ph. (mims.com)
Take carbimazole4
- You can take carbimazole before or after meals. (patient.info)
- I take Carbimazole to bring my thyroid level to normal and this medication is very helpful. (aviatik-sim.de)
- Once you've been diagnosed with an overactive thyroid condition, be aware of how to take carbimazole capsules and their side effects, so don't skip the investigation of the leaflet and manufacturers' recommendations which contain useful information. (mentalitch.com)
- I'm hyperthyroid and take carbimazole. (btf-thyroid.org)
Agranulocytosis6
- Fatalities with carbimazole-induced agranulocytosis have been related. (safegenericpharmacy.com)
- As fatal cases of agranulocytosis with carbimazole have been reported and early treatment of agranulocytosis is essential, it is important that patients should always be warned about the onset of sore throats, bruising or bleeding, mouth ulcers, fever, malaise and should be instructed to stop the drug and to seek medical advice immediately. (mims.com)
- Carbimazole may cause white cell disoders such as neutropenia and agranulocytosis, which may be fatal if treatment with carbimazole is not stopped promptly. (mims.com)
- Carbimazole induced agranulocytosis is a relatively rare but serious side effect and potentially fatal condition reported in 0.1-0.5% of cases treated with antithyroid medications. (bvsalud.org)
- We report a young female with Grave's disease who developed agranulocytosis within 3 weeks of initiation of carbimazole , and recovered within 10 days of treatment with a barrier nursing care , broad-spectrum antibiotics , intravenous corticosteroids and granulocyte colony stimulating factor [ G-CSF ]. (bvsalud.org)
- 4] F. Joseph, N. Younis and D. Bowen Jones: "Treatment of carbimazole-induced agranulocytosis and sepsis with granulocyte colony stimulating factor", Int. J. Clin. (edu.pl)
Thiamazole3
- There is also a risk of acute pancreatitis "following treatment with carbimazole/thiamazole", the MHRA added in its drug safety alert . (chemistanddruggist.co.uk)
- We found no RCTs comparing antithyroid drugs (carbimazole, propylthiouracil, or thiamazole) with each other. (aafp.org)
- There is a risk of cross-allergy between carbimazole, thiamazole and propylthiouracil. (mims.com)
Patients treated with carbimazole1
- Serum thyroxine (T4), triiodothyronine (T3) and thyrotropin (T.S.H.) were measured in 32 hyperthyroid patients treated with carbimazole. (unboundmedicine.com)
Medication1
- The anti-thyroid agent comes in capsules, as one of the main medication dosage forms, which you can buy at the affordable carbimazole capsules price in the credible Kennedy's pharmacy. (mentalitch.com)
Dose6
- Carbimazole was prescribed at 20 mg 8-hourly, and on the development of a skin reaction the dose was decreased to 10 mg 8-hourly. (thefreedictionary.com)
- The median dose of carbimazole was 10 mg (range 10 to 15 mg) and 15 mg (5 to 25 mg) once daily after 3 and 53 weeks, respectively. (wiley.com)
- The mother was receiving her highest dose of carbimazole at the crucial period for development of the choanae, between days 35 and 38. (le.ac.uk)
- What is the optimal medicament dose of carbimazole to treat your medical condition in line with your genomic makeup? (genomicmedicineuk.com)
- Knowing the optimal dose of carbimazole to treat your medical condition, and whether carbimazole is safe to treat your medical condition will empower your doctor to adapt your treatment plan to suit you better. (genomicmedicineuk.com)
- Mumbai, Maharashtra, Prescription/Non prescription: Prescription, Raopura, Vadodara The starting dose for carbimazole is 5 mg every 8 to 12 hours. (rivergirls.nl)
Levothyroxine1
- Sex hormone-binding globulin (SHBG) and corticosteroid-binding globulin (CBG) levels were evaluated in euthyroid (N = 111), hyper- (N = 58) and hypothyroid (N = 38) men, in pre- and postmenopausal women (study 1) and in hyper- (N = 24) and hypothyroid (N = 15) patients before and after treatment with carbimazole or levothyroxine therapy (study 2). (nih.gov)
Neomercazole2
- Carbimazole is available under the brand name Neomercazole. (thehealthguard.net)
- NeoMercazole is contraindicated in patients with a previous history of adverse reactions to carbimazole or to any of the excipients in the composition. (mims.com)
Cheap Carbimazole1
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Propranolol2
- I have had specialist appointments for the last 4 months (complete with blood tests) but in my last appointment (last friday) my T4 (i think) was at 22 which apparently is still apparently too high and so the doctor took me off propranolol and upped my carbimazole to 40mg. (patient.info)
- Thyrotropin receptor antibodies showed high titres of 25.29 U/L. The patient was started on carbimazole (up to 80 mg/day) and propranolol (40 mg, 4 times a day) by a practitioner. (hindawi.com)
Production of thyroid hormones1
- Carbimazole reduces the production of thyroid hormones, but it does not affect the hormones which have already been made and stored by your body. (patient.info)
Thyroxine1
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Antithyroid drug2
- Effects of antithyroid drug carbimazole on the fertility and testicular structure of balb/c mice. (thefreedictionary.com)
- Mechanism of Action of Carbimazole It is a potent antithyroid drug which inhibits thyroid hormone synthesis. (rosheta.com)
Treatment9
- It is interesting that the symptoms we ascribe to carbimazole hypersensitivity developed after a prolonged period of treatment and that these did not worsen with propylthiouracil. (bmj.com)
- In particular, women of childbearing potential taking carbimazole should be advised to use effective contraception during treatment," the MHRA told C+D. (chemistanddruggist.co.uk)
- We present the fourth published case of a child affected with choanal atresia following maternal treatment with carbimazole. (le.ac.uk)
- This genomic DNA test assesses your genetic response to medical treatment with carbimazole. (genomicmedicineuk.com)
- How does your genetic background influence your response to treatment with carbimazole? (genomicmedicineuk.com)
- Can the treatment to your medical condition with carbimazole pose a safety concern to your health because of your genetic background? (genomicmedicineuk.com)
- Patients were re-evaluated after 3 months of treatment as by that time all of them achieved euthyroid state with carbimazole therapy . (bvsalud.org)
- He had previously received carbimazole but had developed an urticarial skin rash after 2 weeks of treatment. (hku.hk)
- Carbimazole is a medicine used in the treatment of overactive thyroid. (axappphealthcare.co.uk)
ANCA1
- We aimed to investigate whether carbimazole therapy was also associated with increased risk of ANCA. (ox.ac.uk)
Hepatitis was suspe2
- Following a normal liver screen, carbimazole induced hepatitis was suspected. (endocrine-abstracts.org)
- Drug induced hepatitis was suspected hence carbimazole was discontinued and propylthiouracil was started. (endocrine-abstracts.org)
Selenium1
- 69) Her systemic and ocular diseases were treated successfully with oral carbimazole and selenium, respectively. (thefreedictionary.com)
Imidazole derivatives1
- About Carbimazole Thyroid peroxidase inhibitors(thioamide),Sulfur-containing imidazole derivatives, Antithyroid. (rosheta.com)
Therapy8
- We report a patient who developed cholestatic jaundice after carbimazole therapy. (endocrine-abstracts.org)
- Necrotizing glomerulonephritis and pulmonary hemorrhage associated with carbimazole therapy. (pneumotox.com)
- Therapy with carbimazole was instituted and revisits were scheduled 2, 6 and 13 weeks after diagnosis. (avmi.net)
- Cats with underlying renal disease were managed by alterations or cessation of carbimazole therapy. (avmi.net)
- Fourteen cats treated with carbimazole and monitored for 13 weeks responded favourably to therapy. (avmi.net)
- Cats with underlying renal disease that became apparent during the study, responded well to alterations or cessation of carbimazole therapy. (avmi.net)
- Carbimazole therapy was found to decrease the prevalence of almost all clinical abnormalities in 14 cats and side-effects were minor and uncommon. (avmi.net)
- Carbimazole should always be discontinued if neutropenia occurs but this case demonstrates that in exceptional circumstances filgrastim can be an effective therapy while continuing carbimazole in the short term. (edu.pl)
Euthyroid1
- Fifty percent of pre-existing GD patients who were thyrotoxic at first presentation were rendered euthyroid at delivery with the appropriate use of carbimazole only (Table 3). (thefreedictionary.com)
Thyrocab1
- The thyrocab (carbimazole) is for thyroid. (medhelp.org)
Medicines1
- The medicines watchdog has updated its advice for pregnant women taking carbimazole, after an EU review of the drug found an increased risk of congenital malformations. (chemistanddruggist.co.uk)
Hyperthyroid cats1
- The efficacy and safety of carbimazole (CBZ) was studied in a series of 45 hyperthyroid cats. (avmi.net)
40mg1
- hi, i too had a very high t4 rading 83 ( normal range 11 - 24) was put on 40mg carbimazole then went under. (patient.info)
Cholestasis1
- Carbimazole causes intracanalicular cholestasis whilst propylthiouracil causes hepatocellular injury. (endocrine-abstracts.org)
Hypersensitivity1
- Carbimazole hypersensitivity was diagnosed, and she started taking propylthiouracil instead (100 mg twice daily). (bmj.com)
Patient3
- One month after omitting carbimazole, the patient had further deteriorated (worsening heart failure and thyrotoxocosis, Free T 3 21.8, Free T 4 73.7) and wished to go ahead with thyroidectomy. (endocrine-abstracts.org)
- Our patient had predominantly cholestatic hepatitis, which is consistent with reported cases of carbimazole-induced hepatic damage. (endocrine-abstracts.org)
- After two months on carbimazole, the patient was admitted to the university hospital for evaluation by an endocrinologist. (hindawi.com)
Prescription4
- Endocrinologist gave me prescription of carbimazole 5 mg twice a day but soon after taking that med I notice my throat is swollen and and hoarseness of voice and eyes are painful. (endocrineweb.com)
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Drug6
- Drug information on Thyrozole (Carbimazole) from Cadila Pharmaceuticals Ltd. (medindia.net)
- Numerous states have enacted carbimazole legislation requiring drug manufacturers to supply justifications for value increases that exceed specified thresholds. (ufrj.br)
- All submissions for drug merchandise which can carbimazole be line extensions, generics and all different sorts of submissions have to be submitted to the NIHB program. (ufrj.br)
- Carbimazole is an anti thyroid drug. (mcdonaldranches.com)
- The main drug for combating this disease and improving the quality of life is carbimazole. (mentalitch.com)
- Carbimazole is the drug used during the rest of pregnancy. (btf-thyroid.org)
Supplier1
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Sepsis1
- Have found out it is not a reaction to the carbimazole but sepsis caused by extremely bad bacterial tonsillitis. (healthunlocked.com)
Sore throat2
- When I was taking Carbimazole I was told that if I developed a sore throat I should stop taking it Immediately. (healthunlocked.com)
- If you develop yellowing of the skin or eyes, mouth ulcers, sore throat, … Carbimazole … SUNSCREEN IS ONLY USED FOR ONE ELEMENT OF PROTECTION. (rivergirls.nl)
Rarely1
- Rarely, carbimazole can cause a decrease in white blood cell levels, which can make you vulnerable to infection. (axappphealthcare.co.uk)
Efficacy1
- The therapeutic efficacy of Carbimazole can be decreased when used in combination with Vatalanib. (drugbank.ca)