Carbenicillin
Penicillins
Gentamicins
Pseudomonas aeruginosa
Ampicillin
Tobramycin
Kanamycin
Microbial Sensitivity Tests
Proteus
Amikacin
Mezlocillin
Enterobacteriaceae
Serratia
Penicillin G
Sisomicin
Klebsiella
Cefamandole
Serratia marcescens
Indenes
Cefazolin
Cephalosporins
beta-Lactams
Bacteria
Cephalosporinase
Piperacillin
Aminoglycosides
Panophthalmitis
Pseudomonas
Netilmicin
Polymyxins
beta-Lactamases
Drug Incompatibility
Penicillanic Acid
Extrachromosomal Inheritance
Lactams
R Factors
Bacteroides fragilis
Drug Resistance, Microbial
Enterobacter
Modified peptidoglycan transpeptidase activity in a carbenicillin-resistant mutant of Pseudomonas aeruginosa 18s. (1/301)
A carbenicillin-resistant mutant of Pseudomonas aeruginosa 18s was found to possess peptidoglycan transpeptidase activity significantly more resistant to inhibition by benzyl penicillin, ampicillin, carbenicillin, and cephaloridine than that of the parent strain. The mutant was more resistant than the parent strain to all of the beta-lactam antibiotics tested, and 50% inhibition values for these compounds against membrane-bound model transpeptidase activity paralleled this increase. The resistance of the mutant to kanamycin, streptomycin, and chloramphenicol was unchanged. (+info)Bacteriologic cure of experimental Pseudomonas keratitis. (2/301)
Two long-term therapy trials with high concentrations of antibiotic were carried out to determine the duration of therapy required to achieve bacteriologic cure of experimental Pseudomonas keratitis in guinea pigs. In the first study, corneas still contained Pseudomonas after 4 days of continual topical therapy with either tobramycin 400 mg/ml, amikacin 250 mg/ml, ticarcillin 400 mg/ml, or carbenicillin 400 mg/ml. In an 11-day trial of topical therapy with tobramycin 20 mg/ml, 34 of 36 corneas grew no Pseudomonas after 6 or more days of therapy. The bacteriologic response to therapy in this model occurred in two phases. About 99.9% or more of the organisms in the cornea were killed in the first 24 hr of therapy. The numbers of bacteria remaining in the cornea declined gradually over the next several days until the corneas were sterile. Optimal antibiotic therapy may include two stages: initial intensive therapy with high concentrations of antibiotic applied frequently to achieve a large rapid decrease in numbers of organisms in the cornea, followed by prolonged, less intensive therapy to eradicate organisms and prevent relapse. (+info)Stability of gentamicin in serum. (3/301)
Patients' sera were divided into three portions when the initial gentamicin level was determined and were stored at -20, 4, and 25 degrees C in plastic or glass tubes. Gentamicin levels were repeated after 1 and 2 days of storage at the respective temperatures. There was no significant difference in gentamicin levels among portions, except those from a patient in renal failure with high serum concentrations of carbenicillin. (+info)Proposed ticarcillin disk control values for Escherichia coli and Pseudomonas aeruginosa: multicenter cooperative study. (4/301)
In a multicenter cooperative controlled study, individual test, accuracy, and precision control values were determined for 75-mug ticarcillin disks with Escherichia coli ATCC 25922 and Pseudomonas aeruginosa ATCC 27853. (+info)An explanation for the apparent host specificity of Pseudomonas plasmid R91 expression. (5/301)
Pseudomonas aeruginosa strain 9169 has been reported to contain a plasmid that expresses resistance to carbenicillin (Cb), kanamycin (Km), and tetracycline (Tc) in Escherichia coli but resistance only to Cb in certain Pseudomonas recipients. The triply resistant plasmid in E. coli belonged to incompatibility (Inc) group P or P-1, whereas the singly resistant plasmid in P. aeruginosa was compatible with IncP-1 plasmids and other plasmids of established Inc specificity but incompatible with plasmid pSR1 that is here used to define a new Pseudomonas Inc group P-10. Additional physical and genetic studies showed that strain 9169 contained not one but two plasmids: IncP-1 plasmid R91a, determining the Cb Km Tc phenotype, and IncP-10 plasmid R91, determining Cb that differed in molecular weight and in EcoRI and BamHI restriction endonuclease recognition sites. Plasmid multiplicity rather than host effects on plasmid gene expression can account for differences in the phenotype of strain 9169 transconjugants to E. coli and P. aeruginosa. (+info)Susceptibility of the anaerobic bacteria, group D streptococci, Enterobacteriaceae, and Pseudomonas to semisynthetic penicillins: carbenicillin, piperacillin, and ticarcillin. (6/301)
Sodium piperacillin T-1220, a new semisynthetic penicillin, was tested in vitro against 297 clinical isolates of anaerobic bacteria and 669 aerobic bacteria by the conventional agar dilution method and compared with carbenicillin and ticarcillin. At a 100-mug/ml concentration the three drugs showed comparable effectiveness against the anaerobes tested. However, at 20 mug/ml, piperacillin was the most effective drug against Bacteroides fragilis, peptostreptococci, and group D streptococci. At this drug concentration only 48% of the B. fragilis strains exhibited susceptibility to carbenicillin only, 64% exhibited susceptibility to ticarcillin but 90% exhibited susceptibility to piperacillin. Similar findings were observed with peptostreptococci and group D streptococci. On a weight basis piperacillin was statistically shown to be the most effective antibiotic of the three tested against these anaerobes. At 20 mug/ml, piperacillin exhibited a statistically significant difference (P < 0.01) over carbenicillin and ticarcillin for Serratia marcescens, Escherichia coli, Klebsiella species, Klebsiella pneumoniae, Pseudomonas isolates, and Citrobacter diversus. At both 20- and 100-mug/ml concentrations, piperacillin appeared to be the most effective (calculated P < 0.01) upon Klebsiella species, K. pneumoniae, S. marcescens, and C. freundii in activity over ticarcillin and carbenicillin. (+info)BL-P1654: a bacteriostatic penicillin? (7/301)
In tube dilution studies, large discrepancies between inhibitory and bactericidal concentrations of BL-P1654 against Pseudomonas were observed. To explain these discrepancies which were not observed with carbenicillin, the kinetics of bacterial killing by these two penicillins were evaluated and compared. The kinetics of bacterial killing by both antimicrobial agents were characteristic of a penicillin, with killing initiating simultaneously with growth. Kill curves revealed the presence of a small number of cells resistant to BL-P1654 which were not detectable macroscopically. Studies on microbial resistance also showed the presence of a small but consistent number of cells resistant to BL-P1654 over a broad range of concentrations above its minimal inhibitory concentration. This pattern of resistance was not observed with carbenicillin. Thus, the discrepancies between inhibitory and bactericidal concentrations of BL-P1654 were not due to any unusual bacteriostatic activity but rather due to a small number of resistant cells whose presence could be detected only by sensitive subculturing techniques. (+info)Mechanism of intestinal absorption of an orally active beta-lactam prodrug: uptake and transport of carindacillin in Caco-2 cells. (8/301)
Absorption characteristics of carindacillin (CIPC) were investigated using Caco-2 cells, and the results were compared with those of its parent drug, carbenicillin (CBPC). Uptake of CBPC was not affected by the metabolic inhibitor or the change in extracellular pH. CBPC appeared to be taken up into Caco-2 cells by passive diffusion. In contrast, the uptake of CIPC was greater at lower extracellular pH and was inhibited in the presence of carbonyl cyanide p-(trifluoromethoxy)phenyl hydrazone, a protonophore. Also, transport of CIPC through Caco-2 cell monolayer was energy and temperature dependent. Moreover, the uptake and transport of CIPC were significantly inhibited in the presence of various monocarboxylic acids, which are the substrates of the monocarboxylic acid transport system(s), whereas the substrates of the oligopeptide transporter had no effect on the uptake or transport of CIPC. These results suggested that the absorption of CIPC may be mediated by the monocarboxylic acid transport system(s), not by the oligopeptide transporter. Furthermore, the uptake and transport of CIPC were approximately 40-fold greater than those of CBPC. Therefore, it is likely that the participation of a carrier-mediated transport in the absorption of CIPC may significantly contribute to the improved absorption of the prodrug over the parent drug. (+info)Carbenicillin is an antibiotic medication that is used to treat a variety of bacterial infections. It is a beta-lactam antibiotic, which means that it works by inhibiting the production of bacterial cell walls, leading to bacterial cell lysis and death. Carbenicillin is typically used to treat infections of the respiratory tract, skin, and urinary tract, as well as certain types of meningitis and sepsis. It is often used in combination with other antibiotics to increase its effectiveness against resistant bacteria. Carbenicillin is typically administered intravenously or intramuscularly, and it may also be available in oral form. It is important to note that carbenicillin can cause allergic reactions in some people, and it may not be effective against certain types of bacteria that are resistant to beta-lactam antibiotics.
Ticarcillin is a semi-synthetic antibiotic that belongs to the penicillin group of drugs. It is used to treat a variety of bacterial infections, including pneumonia, urinary tract infections, skin infections, and infections of the respiratory tract, bones, and joints. Ticarcillin is usually given intravenously or intramuscularly, and it works by inhibiting the growth of bacteria by interfering with their ability to make cell walls. It is often used in combination with other antibiotics to treat more severe or resistant infections. Ticarcillin is generally well-tolerated, but it can cause side effects such as nausea, vomiting, diarrhea, and allergic reactions.
Penicillins are a group of antibiotics that are derived from the Penicillium fungi. They are one of the most widely used antibiotics in the medical field and are effective against a variety of bacterial infections, including pneumonia, strep throat, and urinary tract infections. Penicillins work by inhibiting the production of cell walls in bacteria, which causes the bacteria to burst and die. There are several different types of penicillins, including penicillin G, penicillin V, amoxicillin, and cephalosporins, which have different properties and are used to treat different types of infections. Penicillins are generally well-tolerated by most people, but can cause side effects such as allergic reactions, diarrhea, and nausea. It is important to take penicillins exactly as prescribed by a healthcare provider and to finish the full course of treatment, even if symptoms improve before the medication is finished.
Gentamicins are a group of antibiotics that are commonly used to treat a wide range of bacterial infections. They are derived from the bacterium Streptomyces griseus and are classified as aminoglycosides. Gentamicins are effective against many gram-negative bacteria, including Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa. They are also effective against some gram-positive bacteria, such as Staphylococcus aureus and Enterococcus faecalis. Gentamicins are typically administered intravenously, although they can also be given intramuscularly or topically. They are often used to treat severe infections, such as sepsis, meningitis, and pneumonia. Gentamicins are also used to treat infections in the urinary tract, skin, and soft tissues. However, gentamicins can have serious side effects, including hearing loss, kidney damage, and nerve damage. They should only be used under the supervision of a healthcare professional and with careful monitoring of the patient's response to treatment.
Ampicillin is a type of antibiotic medication that is used to treat a variety of bacterial infections. It is a penicillin antibiotic, which means that it works by inhibiting the growth of bacteria by interfering with their ability to make cell walls. Ampicillin is effective against a wide range of bacteria, including Streptococcus pneumoniae, Haemophilus influenzae, and Escherichia coli. It is often used to treat infections of the respiratory tract, urinary tract, and skin and soft tissues. Ampicillin is usually administered orally or intravenously, and it is generally well-tolerated by most people. However, like all antibiotics, it can cause side effects such as nausea, diarrhea, and allergic reactions.
Tobramycin is an antibiotic medication that is used to treat a variety of bacterial infections, including pneumonia, urinary tract infections, and skin infections. It is a type of aminoglycoside antibiotic, which works by binding to bacterial ribosomes and inhibiting protein synthesis, thereby killing the bacteria. Tobramycin is typically administered intravenously or intramuscularly, and it is also available in an eye drop formulation for the treatment of bacterial conjunctivitis. It is important to note that tobramycin can cause serious side effects, including hearing loss, kidney damage, and allergic reactions, and it should only be used under the supervision of a healthcare professional.
Kanamycin is an aminoglycoside antibiotic that is used to treat a variety of bacterial infections, including pneumonia, meningitis, and urinary tract infections. It works by binding to the ribosomes of bacteria, which are responsible for protein synthesis, and inhibiting their ability to produce essential proteins. This leads to bacterial cell death and the resolution of the infection. Kanamycin is typically administered intravenously or intramuscularly, and it is often used in combination with other antibiotics to treat more severe infections. It is important to note that kanamycin can cause serious side effects, including hearing loss, kidney damage, and allergic reactions, and it should only be used under the supervision of a healthcare professional.
Cephalothin is an antibiotic medication that belongs to the penicillin group of drugs. It is used to treat a variety of bacterial infections, including pneumonia, urinary tract infections, and skin infections. Cephalothin is typically administered intravenously or intramuscularly, and it works by inhibiting the growth and reproduction of bacteria. It is important to note that cephalothin may not be effective against all types of bacteria, and it can also cause side effects such as allergic reactions, nausea, and diarrhea.
Amikacin is an aminoglycoside antibiotic that is used to treat a variety of bacterial infections, including pneumonia, meningitis, and urinary tract infections. It works by binding to the ribosomes of bacteria, which are responsible for protein synthesis, and inhibiting their ability to produce essential proteins. This leads to bacterial cell death and the resolution of the infection. Amikacin is typically administered intravenously, although it can also be given intramuscularly or inhaled. It is important to note that amikacin can cause serious side effects, including hearing loss, kidney damage, and allergic reactions. Therefore, it is typically reserved for use in cases where other antibiotics have failed or are not effective, and it is closely monitored by healthcare providers to minimize the risk of adverse effects.
Mezlocillin is a type of antibiotic medication that belongs to the penicillin group of drugs. It is used to treat a variety of bacterial infections, including pneumonia, urinary tract infections, and skin infections. Mezlocillin is typically administered intravenously or intramuscularly, and it works by inhibiting the growth of bacteria by interfering with their ability to make cell walls. It is important to note that mezlocillin may not be effective against all types of bacteria, and it is important to take the full course of the medication as prescribed by a healthcare provider to ensure that the infection is fully treated.
Penicillin G is a type of antibiotic medication that is derived from the Penicillium fungi. It is a beta-lactam antibiotic that works by inhibiting the growth of bacteria by interfering with their cell wall synthesis. Penicillin G is effective against a wide range of bacterial infections, including pneumonia, meningitis, and sepsis. It is typically administered intravenously or intramuscularly, and is often used as a first-line treatment for serious bacterial infections. However, it is important to note that Penicillin G is not effective against all types of bacteria, and may not be appropriate for use in certain individuals, such as those with penicillin allergies.
Penicillinase is an enzyme produced by certain bacteria that is capable of breaking down penicillin antibiotics, rendering them ineffective. Penicillinase is responsible for the development of resistance to penicillin in many bacterial strains, including Staphylococcus aureus and Streptococcus pneumoniae. The production of penicillinase is a mechanism by which bacteria can survive in the presence of penicillin, which would otherwise be lethal to them. In the medical field, penicillinase is an important factor to consider when selecting antibiotics for the treatment of bacterial infections, as it can reduce the effectiveness of penicillin and other beta-lactam antibiotics.
Sisomicin is an aminoglycoside antibiotic that is used to treat a variety of bacterial infections, including urinary tract infections, respiratory infections, and skin infections. It works by binding to the ribosomes of bacteria, which are responsible for protein synthesis, and inhibiting their ability to produce essential proteins. This leads to bacterial cell death and the resolution of the infection. Sisomicin is typically administered intravenously, although it can also be given intramuscularly or orally in some cases. It is usually used in combination with other antibiotics to increase its effectiveness and reduce the risk of bacterial resistance. Sisomicin can cause a number of side effects, including hearing loss, kidney damage, and allergic reactions. It is important for healthcare providers to carefully monitor patients who are receiving sisomicin to detect and manage any potential side effects.
Cefamandole is an antibiotic medication that belongs to the cephalosporin class of drugs. It is used to treat a variety of bacterial infections, including pneumonia, urinary tract infections, skin infections, and infections of the bones and joints. Cefamandole is typically administered intravenously, although it can also be given orally in some cases. It works by inhibiting the growth of bacteria by interfering with their ability to make cell walls. Like other cephalosporins, cefamandole is effective against a wide range of Gram-negative and Gram-positive bacteria, including many that are resistant to other antibiotics. However, it is important to note that cefamandole can also cause side effects, such as nausea, vomiting, diarrhea, and allergic reactions, and it may not be suitable for everyone.
Indenes are a class of organic compounds that are derived from indene, a six-membered aromatic hydrocarbon. They are characterized by the presence of a double bond between the first and second carbon atoms of the indene ring, and are often used as intermediates in the synthesis of other organic compounds. In the medical field, indenes have been studied for their potential therapeutic applications. Some indenes have been found to have anti-inflammatory, analgesic, and anticonvulsant properties, and have been investigated as potential treatments for a variety of conditions, including pain, epilepsy, and inflammatory diseases. One example of an indene compound with potential therapeutic applications is indomethacin, which is a nonsteroidal anti-inflammatory drug (NSAID) used to treat pain, inflammation, and fever. Other indene derivatives have been studied for their potential use in the treatment of cancer, Alzheimer's disease, and other neurological disorders.
Cefazolin is an antibiotic medication that is used to treat a variety of bacterial infections, including skin infections, respiratory infections, urinary tract infections, and infections of the bones and joints. It is a cephalosporin antibiotic, which means that it works by stopping the growth of bacteria. Cefazolin is usually given intravenously (into a vein) or intramuscularly (into a muscle) and is typically used in hospital settings. It is important to note that cefazolin may not be effective against all types of bacteria, and it is important to use the medication as directed by a healthcare provider.
Cephalosporins are a class of antibiotics that are derived from the mold species Cephalosporium acremonium. They are commonly used to treat a wide range of bacterial infections, including respiratory tract infections, skin infections, urinary tract infections, and infections of the bones and joints. Cephalosporins work by inhibiting the synthesis of bacterial cell walls, which leads to the death of the bacteria. They are generally well-tolerated and have a broad spectrum of activity against many types of bacteria. There are several different classes of cephalosporins, each with its own specific characteristics and uses. The most commonly used classes are first-generation cephalosporins, second-generation cephalosporins, third-generation cephalosporins, and fourth-generation cephalosporins. The choice of which cephalosporin to use depends on the type of infection being treated, the severity of the infection, and the specific characteristics of the bacteria causing the infection.
Beta-Lactams are a class of antibiotics that are derived from the beta-lactam ring structure. They are one of the most widely used classes of antibiotics and are effective against a broad range of bacterial infections. The beta-lactam ring is a six-membered ring with a beta-hydroxy group and an amide group. The beta-lactam antibiotics work by inhibiting the synthesis of the bacterial cell wall, which leads to cell lysis and death. There are several subclasses of beta-lactam antibiotics, including penicillins, cephalosporins, monobactams, and carbapenems. Each subclass has its own unique properties and is effective against different types of bacteria. Beta-lactam antibiotics are often used to treat a variety of bacterial infections, including pneumonia, urinary tract infections, skin infections, and infections of the respiratory, gastrointestinal, and genitourinary tracts. They are generally well-tolerated and have a low risk of side effects, although allergic reactions can occur in some people.
Cephalosporinase is an enzyme produced by certain bacteria that is responsible for breaking down cephalosporin antibiotics, rendering them ineffective. This enzyme is classified as a beta-lactamase, which is a type of enzyme that hydrolyzes the beta-lactam ring of antibiotics, including cephalosporins, penicillins, and monobactams. Cephalosporinase is often found in Gram-negative bacteria, such as Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa. The production of cephalosporinase is one mechanism by which bacteria can become resistant to cephalosporin antibiotics. The presence of cephalosporinase in a bacterial isolate is typically detected using a beta-lactamase detection test, such as the Modified Hodge Test or the Cephalosporin Inhibition Test. If cephalosporinase is detected, it may indicate that the bacteria are resistant to cephalosporin antibiotics and that alternative antibiotics may be needed to treat the infection.
Piperacillin is an antibiotic medication that is used to treat a variety of bacterial infections. It is a beta-lactam antibiotic, which means that it works by inhibiting the growth of bacteria by interfering with their cell walls. Piperacillin is often used in combination with another antibiotic, such as tazobactam, to increase its effectiveness against certain types of bacteria that are resistant to other antibiotics. It is typically administered intravenously, but it can also be given orally in some cases. Piperacillin is used to treat a wide range of infections, including pneumonia, urinary tract infections, and skin infections. It is also sometimes used to prevent infections in people who are at high risk, such as those undergoing surgery or chemotherapy.
Aminoglycosides are a class of antibiotics that are commonly used to treat a variety of bacterial infections, including pneumonia, urinary tract infections, and meningitis. They work by binding to the ribosomes of bacterial cells, which are responsible for protein synthesis, and interfering with this process, leading to the death of the bacteria. Aminoglycosides are typically administered intravenously, although some may also be given by mouth or injection. They are often used in combination with other antibiotics to increase their effectiveness and reduce the risk of bacterial resistance. However, aminoglycosides can also have serious side effects, including hearing loss, kidney damage, and neuromuscular disorders. As a result, they are typically reserved for use in severe infections and are administered with caution, under close medical supervision.
Panophthalmitis is a severe and potentially blinding infection of the eye that affects all structures within the eye, including the cornea, iris, lens, and vitreous humor. It is a medical emergency that requires prompt diagnosis and treatment to prevent permanent vision loss or destruction. The infection can be caused by bacteria, fungi, viruses, or other microorganisms that enter the eye through various means, such as trauma, surgery, or contaminated contact lenses. Symptoms of panophthalmitis may include severe eye pain, redness, swelling, light sensitivity, decreased vision, and discharge from the eye. Diagnosis of panophthalmitis typically involves a thorough eye examination, including a culture of the eye fluid to identify the causative organism. Treatment typically involves the use of antibiotics or antifungal medications, as well as surgery to remove infected tissue and drain any abscesses. In severe cases, enucleation (removal of the eye) may be necessary to prevent the spread of infection to other parts of the body.
Pseudomonas infections are bacterial infections caused by the bacterium Pseudomonas aeruginosa. Pseudomonas aeruginosa is a gram-negative, rod-shaped bacterium that is commonly found in soil, water, and on the surfaces of plants and animals. It can cause a wide range of infections in humans, including pneumonia, urinary tract infections, skin infections, and bloodstream infections. Pseudomonas infections are particularly common in people with weakened immune systems, such as those with cystic fibrosis, cancer, or HIV/AIDS. They can also occur in people who have had recent surgery or who are being treated with antibiotics, which can disrupt the normal balance of bacteria in the body and allow Pseudomonas to grow and cause an infection. Pseudomonas infections can be difficult to treat because Pseudomonas is often resistant to antibiotics. Treatment typically involves a combination of antibiotics and supportive care, such as fluids and oxygen therapy. In severe cases, hospitalization may be necessary.
Azlocillin is a semi-synthetic penicillin antibiotic that is used to treat a variety of bacterial infections. It works by inhibiting the production of cell walls in bacteria, which leads to their death. Azlocillin is often used to treat infections of the respiratory tract, urinary tract, skin, and soft tissues. It is usually administered intravenously or intramuscularly, and it is also available in oral form. Azlocillin is a beta-lactam antibiotic, which means that it is part of a class of antibiotics that includes penicillin and cephalosporins. It is a broad-spectrum antibiotic, which means that it is effective against a wide range of bacteria. However, like all antibiotics, azlocillin can cause side effects, such as nausea, vomiting, diarrhea, and allergic reactions. It is important to take azlocillin exactly as prescribed by a healthcare provider to ensure that it is effective and to minimize the risk of side effects.
Netilmicin is an aminoglycoside antibiotic that is used to treat a variety of bacterial infections, including pneumonia, urinary tract infections, and skin infections. It works by binding to the ribosomes of bacteria, which are responsible for protein synthesis, and inhibiting their ability to produce essential proteins. This leads to bacterial cell death and the resolution of the infection. Netilmicin is typically administered intravenously, although it can also be given intramuscularly or by inhalation. It is usually used in cases where other antibiotics have failed or are not effective, or when the infection is caused by bacteria that are resistant to other antibiotics. Netilmicin can cause a number of side effects, including hearing loss, kidney damage, and allergic reactions. It is important for healthcare providers to carefully monitor patients who are receiving netilmicin to detect and manage any potential side effects.
Polymyxins are a group of antibiotics that are derived from the bacterium Bacillus polymyxa. They are used to treat a variety of bacterial infections, particularly those caused by multidrug-resistant Gram-negative bacteria such as Pseudomonas aeruginosa and Acinetobacter baumannii. Polymyxins work by disrupting the bacterial cell membrane, leading to cell lysis and death. They are often used as a last resort when other antibiotics have failed to be effective. However, polymyxins can have significant side effects, including nephrotoxicity (damage to the kidneys) and neurotoxicity (damage to the nervous system).
Cephaloridine is an antibiotic medication that is used to treat a variety of bacterial infections, including pneumonia, urinary tract infections, and skin infections. It is a cephalosporin antibiotic, which is a type of antibiotic that is derived from the mold Penicillium. Cephaloridine works by inhibiting the growth of bacteria, which helps to kill the bacteria and prevent them from causing infection. It is usually administered intravenously or orally, depending on the type and severity of the infection. Cephaloridine is generally considered to be effective and well-tolerated, but it can cause side effects such as nausea, vomiting, and diarrhea. It is important to take cephaloridine exactly as prescribed by a healthcare provider, and to let them know if you experience any side effects.
Beta-lactamases are enzymes produced by certain bacteria that are responsible for breaking down beta-lactam antibiotics, which are a class of antibiotics that include penicillins, cephalosporins, and monobactams. These enzymes hydrolyze the beta-lactam ring of the antibiotic, rendering it inactive and unable to kill the bacteria. The production of beta-lactamases is a common mechanism of antibiotic resistance in bacteria, and it has become a major problem in the treatment of bacterial infections. Bacteria that produce beta-lactamases are often referred to as "beta-lactamase-producing organisms" or "BLPOs." There are different types of beta-lactamases, and they can be classified based on their substrate specificity, molecular weight, and resistance profile. Some beta-lactamases are specific for a particular class of beta-lactam antibiotics, while others are more broad-spectrum and can hydrolyze multiple classes of antibiotics. The detection and characterization of beta-lactamases is important for the appropriate selection and use of antibiotics in the treatment of bacterial infections. In addition, the development of new antibiotics that are resistant to beta-lactamases is an ongoing area of research in the medical field.
Cloxacillin is an antibiotic medication that is used to treat a variety of bacterial infections, including pneumonia, skin infections, urinary tract infections, and infections of the bones and joints. It is a type of penicillin antibiotic, which works by inhibiting the growth of bacteria. Cloxacillin is typically administered orally or intravenously, and it is usually taken for several days or until the infection has cleared up. It is important to follow the dosing instructions provided by your healthcare provider and to complete the full course of treatment, even if you start to feel better before the medication is finished. Like all antibiotics, cloxacillin can cause side effects, such as nausea, vomiting, diarrhea, and allergic reactions. It is important to tell your healthcare provider if you experience any side effects while taking cloxacillin.
Penicillanic acid is a chemical compound that is the core structure of many antibiotics, including penicillin. It is a cyclic β-lactam ring with an amino group and a carboxylic acid group. The structure of penicillanic acid is responsible for the antibacterial activity of penicillin and related antibiotics. These antibiotics work by inhibiting the synthesis of bacterial cell walls, leading to cell lysis and death. Penicillanic acid is not used as an antibiotic in its own right, but rather as a precursor to the synthesis of many different antibiotics.
Lactams are a class of organic compounds that contain a six-membered ring with an amide group (-CONH-) attached to one of the carbon atoms. They are commonly found in nature and are also synthesized in the laboratory for use in medicine. In the medical field, lactams are used as antibiotics to treat a variety of bacterial infections. The most well-known lactam antibiotics are penicillins, which contain a beta-lactam ring. Other examples of lactam antibiotics include cephalosporins, monobactams, and carbapenems. Lactams are effective against a wide range of bacteria, including gram-positive and gram-negative bacteria. They work by inhibiting the production of cell walls in bacteria, leading to cell lysis and death. However, like all antibiotics, lactams can also have side effects and can lead to the development of antibiotic resistance if not used properly.
Cefoxitin is an antibiotic medication that is used to treat a variety of bacterial infections. It is a member of the cephalosporin class of antibiotics, which work by inhibiting the growth of bacteria. Cefoxitin is typically used to treat infections of the skin, respiratory tract, urinary tract, and abdomen. It is usually given intravenously, although it can also be given by mouth in some cases. Cefoxitin is generally well-tolerated, but like all antibiotics, it can cause side effects such as nausea, diarrhea, and allergic reactions. It is important to take cefoxitin exactly as prescribed by a healthcare provider in order to ensure that it is effective and to minimize the risk of side effects.
Proteus infections refer to a group of bacterial infections caused by the genus Proteus, which includes Proteus mirabilis, Proteus vulgaris, and Proteus penneri. These bacteria are commonly found in the gastrointestinal tract of humans and animals, but can also cause infections in other parts of the body, such as the urinary tract, bloodstream, and respiratory system. Proteus infections can be either acute or chronic, and can range in severity from mild to life-threatening. Symptoms of Proteus infections may include fever, chills, nausea, vomiting, abdominal pain, and diarrhea. Infections of the urinary tract may also cause symptoms such as pain or burning during urination, frequent urination, and cloudy or strong-smelling urine. Proteus infections are typically treated with antibiotics, although the specific antibiotic used may depend on the type of infection and the location of the infection. In some cases, hospitalization may be necessary for severe or life-threatening infections. It is important to seek medical attention if you suspect you may have a Proteus infection, as prompt treatment can help prevent complications and improve outcomes.
Ceftazidime is an antibiotic medication that is used to treat a variety of bacterial infections, including pneumonia, urinary tract infections, and skin infections. It is a cephalosporin antibiotic, which means that it works by stopping the growth of bacteria. Ceftazidime is typically administered intravenously, although it may also be available in an oral form. It is important to note that ceftazidime is only effective against bacterial infections and will not work against viral infections. It is also important to follow the dosing instructions provided by your healthcare provider and to complete the full course of treatment, even if you start to feel better before the medication is finished.
Carbenicillin
Carindacillin
Achromobacter xylosoxidans
Carfecillin
Aeromonas schubertii
Carboxypenicillin
Antimicrobial surface
Kocuria marina
Chiral inversion
History of penicillin
Actinobacillus equuli
Klebsiella pneumoniae
Penicillin
Edward Lowbury
Dokdonia donghaensis
Birmingham Accident Hospital
Extended-spectrum penicillin
Pseudescherichia vulneris
Sisomicin
Benzylpenicillin
RK2 plasmid
List of MeSH codes (D03)
Pseudomonas aeruginosa
Ticarcillin
List of β-lactam antibiotics
List of MeSH codes (D02)
Beecham Group
Limosilactobacillus fermentum
List of drugs: C-Ca
ATC code J01
C-1385-1GM -
Carbenicillin Disodium Salt, 1 G
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Penicillin4
- Carbenicillin Disodium Salt is a penicillin-derived β-lactam antibiotic that interferes with cell wall synthesis, primarily in gram-negative bacteria such as Pseudomonas aeruginosa , while showing low toxicity to plant tissues. (agscientific.com)
- Carbenicillin acylates the penicillin-sensitive transpeptidase C-terminal area by opening the lactam ring. (agscientific.com)
- His diagnosis indicated pneumonia which rapidly progressed during therapy with penicillin but which responded to the combination of gentamicin and carbenicillin. (cdc.gov)
- In situation you are allergic to this drug or various other penicillin antibiotics carbenicillin. (aleijten.com)
Ampicillin1
- Carbenicillin is more stable than Ampicillin and can be used in place of Ampicillin in most applications. (addgene.org)
Indanyl1
- Read user comments about the side effects, benefits, and effectiveness of carbenicillin indanyl sodium oral. (webmd.com)
Resistance1
- AGL-1 also has rifampicin and carbenicillin resistance genes in the genome useful for selection. (goldbio.com)
Plates2
- LB Agar Plates with Carbenicillin-100. (thomassci.com)
- Use sterile toothpicks to patch at least 20 colonies onto pre-warmed plates of PIA, PIA supplemented with 10%sucrose, and PIA supplemented with carbenicillin. (jove.com)
Disodium1
- Carbenicillin indanyl disodium is acceptable in nursing mothers. (nih.gov)
Ampicillin2
- The strains were sensitive to chloramphenicol, co-trimoxazole, tetracycline and gentamicin but resistant to ampicillin and carbenicillin. (who.int)
- The simple thing is to avoid certain medications when you're allergic to penicillin V, such as amoxicillin, dicloxacillin, carbenicillin, ampicillin, and oxacillin. (searchandrestore.com)
Gentamicin1
- His diagnosis indicated pneumonia which rapidly progressed during therapy with penicillin but which responded to the combination of gentamicin and carbenicillin. (cdc.gov)
Piperacillin6
- In this controlled, randomized clinical trial we compared piperacillin and carbenicillin in the treatment of complicated urinary tract infections. (nih.gov)
- 24 patients received piperacillin 150 mg/kg/day for 7.2 +/- 2.75 days and 17 patients received carbenicillin 200 mg/kg/day for 7.5 +/- 2.90 days. (nih.gov)
- Although the clinical cure rate significantly favored carbenicillin treatment (p less than 0.01), the sum of the percentages of cases with clinical cure and clinical improvement were similar between groups: 91.6% for piperacillin and 88.2% for carbenicillin. (nih.gov)
- The bacteriologic cure rates for piperacillin and carbenicillin patients (54.1 and 47.0%, respectively) were not significantly different (p greater than 0.05). (nih.gov)
- Superinfections developed in 12.5 and 17.6% of piperacillin and carbenicillin patients, respectively, and were due to Klebsiella pneumonia, Proteus mirabilis, Citrobacter diversus, and Pseudomonas aeruginosa. (nih.gov)
- However, carbenicillin caused elevations in liver enzymes more frequently than piperacillin (p less than 0.05). (nih.gov)
Date1
- In chronic bacterial prostatitis, results to date suggest that ofloxacin may be more effective clinically and as effective micro- biologically as carbenicillin. (nih.gov)