Benzo-indoles similar to CARBOLINES which are pyrido-indoles. In plants, carbazoles are derived from indole and form some of the INDOLE ALKALOIDS.
A genus of gram-negative, aerobic, rod-shaped bacteria characterized by an outer membrane that contains glycosphingolipids but lacks lipopolysaccharide. They have the ability to degrade a broad range of substituted aromatic compounds.
A plant genus of the family RUTACEAE. Members contain murrayanine, koenine, isomahanine, kwangsine, siamenol, murrayafoline A, murrayaquinone A and other cytotoxic carbazolequinones.
Non-heme iron-containing enzymes that incorporate two atoms of OXYGEN into the substrate. They are important in biosynthesis of FLAVONOIDS; GIBBERELLINS; and HYOSCYAMINE; and for degradation of AROMATIC HYDROCARBONS.
A plant family in the order Sapindales that grows in warmer regions and has conspicuous flowers.
A family of gram-positive, aerobic actinomycetes found in soil and animal tissue. Some species are the cause of infection in man and animals.
Pyrido-CARBAZOLES originally discovered in the bark of OCHROSIA ELLIPTICA. They inhibit DNA and RNA synthesis and have immunosuppressive properties.
Elimination of ENVIRONMENTAL POLLUTANTS; PESTICIDES and other waste using living organisms, usually involving intervention of environmental or sanitation engineers.
A plant genus of the family RUTACEAE. Members contain anethole and CARBAZOLES.
Benzoic acids, salts, or esters that contain an amino group attached to carbon number 2 or 6 of the benzene ring structure.
A by-product of the destructive distillation of coal used as a topical antieczematic. It is an antipruritic and keratoplastic agent used also in the treatment of psoriasis and other skin conditions. Occupational exposure to soots, tars, and certain mineral oils is known to be carcinogenic according to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985) (Merck Index, 11th ed).
Oxidases that specifically introduce DIOXYGEN-derived oxygen atoms into a variety of organic molecules.
Cytoplasmic proteins that bind certain aryl hydrocarbons, translocate to the nucleus, and activate transcription of particular DNA segments. AH receptors are identified by their high-affinity binding to several carcinogenic or teratogenic environmental chemicals including polycyclic aromatic hydrocarbons found in cigarette smoke and smog, heterocyclic amines found in cooked foods, and halogenated hydrocarbons including dioxins and polychlorinated biphenyls. No endogenous ligand has been identified, but an unknown natural messenger with a role in cell differentiation and development is suspected.
A genus of gram-negative, aerobic, rod-shaped bacteria widely distributed in nature. Some species are pathogenic for humans, animals, and plants.
A chemical by-product that results from burning or incinerating chlorinated industrial chemicals and other hydrocarbons. This compound is considered an environmental toxin, and may pose reproductive, as well as, other health risks for animals and humans.
Iron-containing proteins that transfer electrons, usually at a low potential, to flavoproteins; the iron is not present as in heme. (McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
Chlorinated hydrocarbons containing heteroatoms that are present as contaminants of herbicides. Dioxins are carcinogenic, teratogenic, and mutagenic. They have been banned from use by the FDA.
Benzopyrroles with the nitrogen at the number one carbon adjacent to the benzyl portion, in contrast to ISOINDOLES which have the nitrogen away from the six-membered ring.
Organic nitrogenous bases. Many alkaloids of medical importance occur in the animal and vegetable kingdoms, and some have been synthesized. (Grant & Hackh's Chemical Dictionary, 5th ed)
A group of 1,2-benzenediols that contain the general formula R-C6H5O2.
A chemical element having an atomic weight of 106.4, atomic number of 46, and the symbol Pd. It is a white, ductile metal resembling platinum, and following it in abundance and importance of applications. It is used in dentistry in the form of gold, silver, and copper alloys.
A family of gram-negative, asporogenous rods or ovoid cells, aerobic or facultative anaerobic chemoorganotrophs. They are commonly isolated from SOIL, activated sludge, or marine environments.
Changing an open-chain hydrocarbon to a closed ring. (McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
A liver microsomal cytochrome P-450 monooxygenase capable of biotransforming xenobiotics such as polycyclic hydrocarbons and halogenated aromatic hydrocarbons into carcinogenic or mutagenic compounds. They have been found in mammals and fish. This enzyme, encoded by CYP1A1 gene, can be measured by using ethoxyresorufin as a substrate for the ethoxyresorufin O-deethylase activity.
The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.
Drugs used to treat or prevent skin disorders or for the routine care of skin.
Proteins found in any species of bacterium.
A potent mutagen and carcinogen. It is a public health concern because of its possible effects on industrial workers, as an environmental pollutant, an as a component of tobacco smoke.
A set of genes descended by duplication and variation from some ancestral gene. Such genes may be clustered together on the same chromosome or dispersed on different chromosomes. Examples of multigene families include those that encode the hemoglobins, immunoglobulins, histocompatibility antigens, actins, tubulins, keratins, collagens, heat shock proteins, salivary glue proteins, chorion proteins, cuticle proteins, yolk proteins, and phaseolins, as well as histones, ribosomal RNA, and transfer RNA genes. The latter three are examples of reiterated genes, where hundreds of identical genes are present in a tandem array. (King & Stanfield, A Dictionary of Genetics, 4th ed)
Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included.
The formation of crystalline substances from solutions or melts. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Complex sets of enzymatic reactions connected to each other via their product and substrate metabolites.
A potent noncompetitive antagonist of the NMDA receptor (RECEPTORS, N-METHYL-D-ASPARTATE) used mainly as a research tool. The drug has been considered for the wide variety of neurodegenerative conditions or disorders in which NMDA receptors may play an important role. Its use has been primarily limited to animal and tissue experiments because of its psychotropic effects.
The giving of drugs, chemicals, or other substances by mouth.
An alkylating carcinogen that produces gastrointestinal and probably lung and nervous system tumors.
A family of tricyclic hydrocarbons whose members include many of the commonly used tricyclic antidepressants (ANTIDEPRESSIVE AGENTS, TRICYCLIC).
Product of the oxidation of ethanol and of the destructive distillation of wood. It is used locally, occasionally internally, as a counterirritant and also as a reagent. (Stedman, 26th ed)
Derivatives of OXALIC ACID. Included under this heading are a broad variety of acid forms, salts, esters, and amides that are derived from the ethanedioic acid structure.
Exclusive legal rights or privileges applied to inventions, plants, etc.
Organic compounds containing the carboxy group (-COOH). This group of compounds includes amino acids and fatty acids. Carboxylic acids can be saturated, unsaturated, or aromatic.
Cholestadiene derivatives containing a hydroxy group anywhere in the molecule.
An inorganic compound that is used as a source of iodine in thyrotoxic crisis and in the preparation of thyrotoxic patients for thyroidectomy. (From Dorland, 27th ed)
A subfield of acoustics dealing in the radio frequency range higher than acoustic SOUND waves (approximately above 20 kilohertz). Ultrasonic radiation is used therapeutically (DIATHERMY and ULTRASONIC THERAPY) to generate HEAT and to selectively destroy tissues. It is also used in diagnostics, for example, ULTRASONOGRAPHY; ECHOENCEPHALOGRAPHY; and ECHOCARDIOGRAPHY, to visually display echoes received from irradiated tissues.
Guanine nucleotides which contain deoxyribose as the sugar moiety.
Agencies of the FEDERAL GOVERNMENT of the United States.
A 34-amino acid polypeptide antibiotic produced by Streptococcus lactis. It has been used as a food preservative in canned fruits and vegetables, and cheese.
The process of discovering or asserting an objective or intrinsic relation between two objects or concepts; a faculty or power that enables a person to make judgments; the process of bringing to light and asserting the implicit meaning of a concept; a critical evaluation of a person or situation.
A group of compounds derived from ammonia by substituting organic radicals for the hydrogens. (From Grant & Hackh's Chemical Dictionary, 5th ed)
A basis of value established for the measure of quantity, weight, extent or quality, e.g. weight standards, standard solutions, methods, techniques, and procedures used in diagnosis and therapy.

Prior exposure to neurotrophins blocks inhibition of axonal regeneration by MAG and myelin via a cAMP-dependent mechanism. (1/1680)

MAG is a potent inhibitor of axonal regeneration. Here, inhibition by MAG, and myelin in general, is blocked if neurons are exposed to neurotrophins before encountering the inhibitor; priming cerebellar neurons with BDNF or GDNF, but not NGF, or priming DRG neurons with any of these neurotrophins blocks inhibition by MAG/myelin. Dibutyryl cAMP also overcomes inhibition by MAG/myelin, and cAMP is elevated by neurotrophins. A PKA inhibitor present during priming abrogates the block of inhibition. Finally, if neurons are exposed to MAG/myelin and neurotrophins simultaneously, but with the Gi protein inhibitor, inhibition is blocked. We suggest that priming neurons with particular neurotrophins elevates cAMP and activates PKA, which blocks subsequent inhibition of regeneration and that priming is required because MAG/myelin activates a Gi protein, which blocks increases in cAMP. This is important for encouraging axons to regrow in vivo.  (+info)

The ras oncogene-mediated sensitization of human cells to topoisomerase II inhibitor-induced apoptosis. (2/1680)

BACKGROUND: Among the inhibitors of the enzyme topoisomerase II (an important target for chemotherapeutic drugs) tested in the National Cancer Institute's In Vitro Antineoplastic Drug Screen, NSC 284682 (3'-hydroxydaunorubicin) and NSC 659687 [9-hydroxy-5,6-dimethyl-1-(N-[2(dimethylamino)ethyl]carbamoyl)-6H-pyrido -(4,3-b)carbazole] were the only compounds that were more cytotoxic to tumor cells harboring an activated ras oncogene than to tumor cells bearing wild-type ras alleles. Expression of the multidrug resistance proteins P-glycoprotein and MRP (multidrug resistance-associated protein) facilitates tumor cell resistance to topoisomerase II inhibitors. We investigated whether tumor cells with activated ras oncogenes showed enhanced sensitivity to other topoisomerase II inhibitors in the absence of the multidrug-resistant phenotype. METHODS: We studied 20 topoisomerase II inhibitors and individual cell lines with or without activated ras oncogenes and with varying degrees of multidrug resistance. RESULTS: In the absence of multidrug resistance, human tumor cell lines with activated ras oncogenes were uniformly more sensitive to most topoisomerase II inhibitors than were cell lines containing wild-type ras alleles. The compounds NSC 284682 and NSC 659687 were especially effective irrespective of the multidrug resistant phenotype. The ras oncogene-mediated sensitization to topoisomerase II inhibitors was far more prominent with the non-DNA-intercalating epipodophyllotoxins than with the DNA-intercalating inhibitors. This difference in sensitization appears to be related to a difference in apoptotic sensitivity, since the level of DNA damage generated by etoposide (an epipodophyllotoxin derivative) in immortalized human kidney epithelial cells expressing an activated ras oncogene was similar to that in the parental cells, but apoptosis was enhanced only in the former cells. CONCLUSIONS: Activated ras oncogenes appear to enhance the sensitivity of human tumor cells to topoisomerase II inhibitors by potentiating an apoptotic response. Epipodophyllotoxin-derived topoisomerase II inhibitors should be more effective than the DNA-intercalating inhibitors against tumor cells with activated ras oncogenes.  (+info)

A requirement for protein kinase C inhibition for calcium-triggered apoptosis in acute lymphoblastic leukemia cells. (3/1680)

We have evaluated the cytotoxicities of the combinations of calcium mobilizers and PKC inhibitors against human acute lymphoblastic leukemia (ALL) cells. Here we report that calcium mobilizers alone or PKC inhibitors alone do not induce apoptosis in human ALL cells. However, the combinations of calcium mobilizers with potent inhibitors of PKC cause significant apoptosis in ALL cells. Our results provide experimental evidence that PKC blocks Ca2+-triggered apoptosis in human ALL cells. Thus, PKC inhibitors can be used to enhance the antileukemic activity of chemical or biological agents that trigger an apoptotic calcium signal in ALL cells. The exquisite sensitivity of ALL cells to calcium-dependent apoptosis in the presence of PKC inhibitors could provide the basis for new treatment programs against ALL.  (+info)

Stimulation of ultraviolet-induced apoptosis of human fibroblast UVr-1 cells by tyrosine kinase inhibitors. (4/1680)

Damnacanthal is an anthraquinone compound isolated from the root of Morinda citrifolia and was reported to have a potent inhibitory activity towards tyrosine kinases such as Lck, Src, Lyn and EGF receptor. In the present study, we have examined the effects of damnacanthal on ultraviolet ray-induced apoptosis in ultraviolet-resistant human UVr-1 cells. When the cells were treated with damnacanthal prior to ultraviolet irradiation, DNA fragmentation was more pronounced as compared to the case of ultraviolet irradiation alone. The other tyrosine kinase inhibitors, herbimycin A and genistein, also caused similar effects on ultraviolet-induced apoptosis but to a lesser extent. Serine/threonine kinase inhibitors, K252a, staurosporine and GF109203X, rather suppressed the ultraviolet-induced DNA cleavage. Immunoblot analysis showed that pretreatment with damnacanthal followed by ultraviolet irradiation increased the levels of phosphorylated extracellular signal-regulated kinases and stress-activated protein kinases. However, the other tyrosine kinase inhibitors did not increase the phosphorylation of extracellular signal-regulated kinases but stimulated phosphorylation of stress-activated protein kinases. Consequently, the ultraviolet-induced concurrent increase in both phosphorylated extracellular signal-regulated kinases and stress-activated protein kinases after pretreatment with damnacanthal might be characteristically related to the stimulatory effect of damnacanthal on ultraviolet-induced apoptosis.  (+info)

Involvement of phosphodiesterase-cGMP-PKG pathway in intracellular Ca2+ oscillations in pituitary GH3 cells. (5/1680)

The present study investigates the potential role of the Ca2+-calmodulin-dependent type I phosphodiesterase (PDE)-cGMP-protein kinase G (PKG) pathway in spontaneous [Ca2+]i oscillations in GH3 cells using fura-2 single cell videoimaging. Vinpocetine (2.5-50 microM), a selective inhibitor of type I PDE, induced a concentration-dependent inhibition of spontaneous [Ca2+]i oscillations in these pituitary cells, and at the same time produced an increase of the intracellular cGMP content. The cell permeable cGMP analog N2,2'-O-dibutyryl-cGMP (dB-cGMP) (1 mM) caused a progressive reduction of the frequency and the amplitude of spontaneous [Ca2+]i oscillations when added to the medium. KT5823 (400 nM), a selective inhibitor of cGMP-dependent protein kinase (PKG), produced an increase of baseline [Ca2+]i and the disappearance of spontaneous [Ca2+]i oscillations. When KT5823 was added before vinpocetine, the PKG inhibitor counteracted the [Ca2+]i lowering effect of the cGMP catabolism inhibitor. Finally, the removal of extracellular Ca2+ or the blockade of L-type voltage-sensitive calcium channels (VSCC) by nimodipine produced a decrease of cytosolic cGMP levels. Collectively, the results of the present study suggest that spontaneous [Ca2+]i oscillations in GH3 cells may be regulated by the activity of type I PDE-cGMP-PKG pathway.  (+info)

In vitro and in vivo characterization of intrinsic sympathomimetic activity in normal and heart failure rats. (6/1680)

Clinical studies conducted with carvedilol suggest that beta-adrenoceptor antagonism is an effective therapeutic approach to the treatment of heart failure. However, many beta-adrenoceptor antagonists are weak partial agonists and possess significant intrinsic sympathomimetic activity (ISA), which may be problematic in the treatment of heart failure. In the present study, the ISAs of bucindolol, xamoterol, bisoprolol, and carvedilol were evaluated and compared in normal rats [Sprague-Dawley (SD)], in rats with confirmed heart failure [spontaneously hypertensive heart failure (SHHF)], and in isolated neonatal rat cardiomyocytes. At equieffective beta1-adrenolytic doses, the administration of xamoterol and bucindolol produced a prolonged, equieffective, and dose-related increase in heart rate in both pithed SD rats (ED50 = 5 and 40 microgram/kg, respectively) and SHHF rats (ED50 = 6 and 30 microgram/kg, respectively). The maximum effect of both compounds in SHHF rats was approximately 50% of that observed in SD rats. In contrast, carvedilol and bisoprolol had no significant effect on resting heart rate in the pithed SD or SHHF rat. The maximum increase in heart rate elicited by xamoterol and bucindolol was inhibited by treatment with propranolol, carvedilol, and betaxolol (beta1-adrenoceptor antagonist) but not by ICI 118551 (beta2-adrenoceptor antagonist) in neonatal rat. When the beta-adrenoceptor-mediated cAMP response was examined in cardiomyocytes, an identical partial agonist/antagonist response profile was observed for all compounds, demonstrating a strong correlation with the in vivo results. In contrast, GTP-sensitive ligand binding and tissue adenylate cyclase activity were not sensitive methods for detecting beta-adrenoceptor partial agonist activity in the heart. In summary, xamoterol and bucindolol, but not carvedilol and bisoprolol, exhibited direct beta1-adrenoceptor-mediated ISA in normal and heart failure rats.  (+info)

Tolerability and efficacy of carvedilol in patients with New York Heart Association class IV heart failure. (7/1680)

OBJECTIVES: The purpose of this study was to assess the tolerability and efficacy of carvedilol in patients with New York Heart Association (NYHA) functional class IV symptoms. BACKGROUND: Carvedilol, a nonselective beta-adrenergic blocking drug with alpha-adrenergic blocking and antioxidant properties, has been shown to improve left ventricular function and clinical outcome in patients with mild to moderate chronic heart failure. METHODS: We retrospectively analyzed the outcomes of 230 patients with heart failure treated with carvedilol who were stratified according to baseline functional class: 63 patients were NYHA class IV and 167 were NYHA class I, II or III. Carvedilol was commenced at 3.125 mg b.i.d. and titrated to 25 mg b.i.d. as tolerated. Patients with class IV symptoms were older (p = 0.03), had lower left ventricular fractional shortening (p < 0.001), had lower six-min walk distance (p < 0.001) and were receiving more heart failure medications at baseline compared with less symptomatic patients. RESULTS: Nonfatal adverse events while taking carvedilol occurred more frequently in class IV patients (43% vs. 24%, p < 0.0001), and more often resulted in permanent withdrawal of the drug (25% vs. 13%, p < 0.01). Thirty-seven (59%) patients who were NYHA class IV at baseline had improved by one or more functional class at 3 months, 8 (13%) were unchanged and 18 (29%) had deteriorated or died. Among the less symptomatic group, 62 (37%) patients had improved their NYHA status at 3 months, 73 (44%) were unchanged and 32 (19%) had deteriorated or died. The differences in symptomatic outcome at three months between the two groups were statistically significant (p = 0.001, chi-square analysis). Both groups demonstrated similar significant improvements in left ventricular dimensions and systolic function. CONCLUSIONS: Patients with chronic NYHA class IV heart failure are more likely to develop adverse events during initiation and dose titration when compared with less symptomatic patients but are more likely to show symptomatic improvement in the long term. We conclude that carvedilol is a useful adjunctive therapy for patients with NYHA class IV heart failure; however, they require close observation during initiation and titration of the drug.  (+info)

Membrane fusion promoters and inhibitors have contrasting effects on lipid bilayer structure and undulations. (8/1680)

It has been established that the fusion of both biological membranes and phospholipid bilayers can be modulated by altering their lipid composition (Chernomordik et al., 1995 .J. Membr. Biol. 146:3). In particular, when added exogenously between apposing membranes, monomyristoylphosphatidylcholine (MMPC) inhibits membrane fusion, whereas glycerol monoleate (GMO), oleic acid (OA), and arachidonic acid (AA) promote fusion. This present study uses x-ray diffraction to investigate the effects of MMPC, GMO, OA, and AA on the bending and stability of lipid bilayers when bilayers are forced together with applied osmotic pressure. The addition of 10 and 30 mol% MMPC to egg phosphatidylcholine (EPC) bilayers maintains the bilayer structure, even when the interbilayer fluid spacing is reduced to approximately 3 A, and increases the repulsive pressure between bilayers so that the fluid spacing in excess water increases by 5 and 15 A, respectively. Thus MMPC increases the undulation pressure, implying that the addition of MMPC promotes out-of-plane bending and decreases the adhesion energy between bilayers. In contrast, the addition of GMO has minor effects on the undulation pressure; 10 and 50 mol% GMO increase the fluid spacing of EPC in excess water by 0 and 2 A, respectively. However, x-ray diffraction indicates that, at small interbilayer separations, GMO, OA, or AA converts the bilayer to a structure containing hexagonally packed scattering units approximately 50 A in diameter. Thus GMO, OA, or AA destabilizes bilayer structure as apposing bilayers are brought into contact, which could contribute to their role in promoting membrane fusion.  (+info)

Article Investigation of carbazole degradation by the sono-Fenton process. The present report aimed to describe the roles of ultrasonic power and reaction time in the Fenton reagent-based degradation of carbazole in wastewater, and to analyze the eff...
6-Formylindolo[3,2-b]carbazole (FICZ) is a potent aryl hydrocarbon receptor (AHR) agonist that is efficiently metabolized by AHR-regulated cytochrome P4501 enzymes. FICZ is a proposed physiological AHR ligand that induces its own degradation as part of a regulatory negative feedback loop. In vitro studies in cells show that CYP1 inhibition in the presence of FICZ results in enhanced AHR activation, suggesting that FICZ accumulates in the cell when its metabolism is blocked. We used zebrafish (Danio rerio) embryos to investigate the in vivo effects of FICZ when CYP1A is knocked down or inhibited. Embryos were injected with morpholino antisense oligonucleotides targeting CYP1A (CYP1A-MO), Ahr2, or a combination of both. FICZ exposure of non-injected embryos or embryos injected with control morpholino had little effect. In CYP1A-MO-injected embryos, however, FICZ dramatically increased mortality, incidence and severity of pericardial edema and circulation failure, reduced hatching frequency, ...
Objective: To assess whether chronic treatment with carvedilol can increase myocardial blood flow (MBF) and MBF reserve in idiopathic dilated cardiomyopathy (IDC). Study design: In a double-blind, placebo-controlled trial, 16 consecutive patients with IDC were randomised to treatment with either carvedilol up to 25 mg twice a day (n = 8, 7 men, mean (SD) age 60 (9) years, mean (SD) left ventricular ejection fraction (LVEF) 30% (5%)), or placebo (n = 8 , 6 men, mean (SD) age 62 (9) years, mean (SD) LVEF 28% (6%), NS vs carvedilol group). Before and 6 months after treatment, regional MBF was measured at rest and after intravenous injection of dipyridamole (Dip; 0.56 mg/kg in 4 min) by positron emission tomography and using 13N-ammonia as a flow tracer. Exercise capacity was assessed as the time duration in a maximal bicycle exercise stress test. Results: Carvedilol induced a significant decrease in heart rate at rest and during maximal exercise, and an increase in exercise capacity. Absolute MBF ...
TY - JOUR. T1 - Carvedilol increases ciclosporin bioavailability by inhibiting P-glycoprotein-mediated transport. AU - Amioka, Katsuo. AU - Kuzuya, Takafumi. AU - Kushihara, Hideyuki. AU - Ejiri, Masayuki. AU - Nitta, Atsumi. AU - Nabeshima, Toshitaka. PY - 2007/10/1. Y1 - 2007/10/1. N2 - Carvedilol is often used to treat hypertension and for prophylaxis in vascular sclerosis in renal transplant recipients, who require concomitant treatment with ciclosporin. However, there are few reports regarding the pharmacokinetic interactions between carvedilol and ciclosporin. We have investigated the potential effects of carvedilol on the pharmacokinetics of ciclosporin, and examined the inhibitory effects of carvedilol on P-glycoprotein-mediated transcellular transport using Caco2 cells. Ciclosporin alone or with carvedilol was orally or intravenously administered to rats. The oral administration of carvedilol (10 mg kg-1) with Ciclosporin (10 mg kg-1) increased the whole blood concentration of ...
7H-Dibenzo(c,g)carbazole is carcinogenic in the mouse, rat, hamster and possibly in the dog. It has both a local and systemic carcinogenic effect. Following oral administration in the mouse, forestomach tumours and hepatomas occurred; intratracheal administration to hamsters produced tumours of the respiratory tract. In comparison with benzo(a)pyrene, 7H-dibenzo(c,g)carbazole appears to be a stronger respiratory tract carcinogen for the hamster. ...
Carvedilol 25 mg used for, para que sirve la carvedilol 6.25, carvedilol goodrx, carvedilol bula para que serve, goodrx carvedilol 25 mg, carvedilol price costco, carvedilol recall
Histamine can u symptoms of sneezing, itching, spacy eyes, and runny info on carvedilol. Acetaminophen and diphenhydramine is a few medicine used to end headache. This combination product contains 2 years, acetaminophen and an antihistamine. Acetaminophen studies to reduce info on carvedilol andor quickly to moderate pain (such as other, backache, achespains due to person strain, cold, or flu). The antihistamine in this medication may cause drowsiness, and therefore it can also be. Tho interaction with Tylenol PM is not a year with your blood clotting drugs, you also take taking herbs. More:. ...
The purpose of the study is to measure decline in episodic memory in participants with early AD taking carvedilol compared to placebo treatment as evidenced by the Hopkins Verbal Learning Test (HVLT). cerebrospinal fluid levels of Aβ oligomers in early AD, will be measured in participants receiving carvedilol treatment when compared to placebo treatment. Adverse effects will be monitored in participants receiving carvedilol when compared to placebo.. To assess adverse events, routine chemistry and hematology studies, vital signs, and electrocardiographic parameters before and after 6 months randomized placebo-controlled double-blind treatment with carvedilol at a target dose of 25 mg daily, comparing 25 early AD participants taking carvedilol vs. 25 early AD participants taking placebo. ...
Rebeccamycin is an indolocarbazole isolated from Lechevalieria aerocolonigenes. Rebeccamycin displays selective antitumor activity against several cell lines. Analogues of rebeccamycin have been tested in clinical trials for cancer therapy ...
6-cyano-5-methoxy-12-methylindolo(2,3-a)carbazole: structure given in first source; indolocarbazole from blue-green algae Nostoc sphaericum; active against HSV II
TY - JOUR. T1 - 3-(trimethylsilylethynyl)carbazole. AU - Khan, Muhammad S.. AU - Male, Louise. AU - Raithby, Paul R.. AU - Teat, Simon J.. AU - Bond, Andrew D.. PY - 2003/9. Y1 - 2003/9. N2 - The title compound, [Si(CH3)3(C14H 8N)] is a TMS-protected mono-alkyne. It is used as a model species for platinum σ-acetylide compounds of which it is a precursor. Such compounds are of interest due to the extended π-conjugation through the hetero-aromatic linker unit in the backbone.. AB - The title compound, [Si(CH3)3(C14H 8N)] is a TMS-protected mono-alkyne. It is used as a model species for platinum σ-acetylide compounds of which it is a precursor. Such compounds are of interest due to the extended π-conjugation through the hetero-aromatic linker unit in the backbone.. UR - http://www.scopus.com/inward/record.url?scp=18444401964&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=18444401964&partnerID=8YFLogxK. U2 - 10.1107/S1600536803017963. DO - 10.1107/S1600536803017963. M3 - ...
207-88-5 - SRFZWNXMRFIYRW-UHFFFAOYSA-N - 13H-(Benzo(g)pyrido(2,3-a))carbazole - Similar structures search, synonyms, formulas, resource links, and other chemical information.
2016 Global and Chinese Carbazole CAS 86 74 8 Industry Market: Get detailed Research report with in-depth trend Analysis, growth outlook & forecast
We prospectively investigated the consequences of adding carvedilol to the typical treatment of ischemic and nonischemic dilated cardiomyopathy (DCM), by measuring the plasma degrees of pro-inflammatory cytokines. In nonischemic individuals on carvedilol, IL-6 and TNF- amounts dropped considerably (P=0.018 and P=0.004, respectively). The remaining ventricular ejection portion more than doubled (P=0.006). In nonischemic individuals on regular treatment, no significant switch occurred in virtually any worth. Carvedilol suppressed the plasma degrees CHIR-99021 manufacture of TNF- and IL-6 both in ischemic and nonischemic individuals. The carvedilol impact was even more pronounced in individuals with nonischemic dilated cardiomyopathy than in people that have ischemic disease. ensure that you the paired-sample check were found in the evaluation of the adjustments that were appropriate with the standard distribution. The Mann-Whitney SFN U and Wilcoxon assessments were used to investigate changes ...
OBJECTIVES. Carprofen is a non-steroidal anti-inflammatory drug. According to its anti-inflammatory effects and low renal toxicity, carprofen perioperative use is relatively safe.. Methods for assessment pain in veterinary are adaptations of scales used in human pain measurement. The most currently used are the simple descriptive scale, numerical rating scale and visual analogue scale. Pain score is based on subjective behavioral observation.. Multiparametrics scales, using different variables, try to minimize subjectivity of observer. The objective of this study is to determinate effectiveness of the carprofen in the control of postoperative immediate pain in dogs using a multiparametric scale.. MATERIALS. Dogs undergoing surgery were allocated by random draw into 3 groups: group A: 5 dogs given carprofen (4 mg/kg) prior surgery and saline (0.9% NaCl) solution after surgery, group B: 5 dogs given saline solution prior surgery and carprofen after surgery, group C: 5 dogs given saline solution ...
OBJECTIVES. Carprofen is a non-steroidal anti-inflammatory drug. According to its anti-inflammatory effects and low renal toxicity, carprofen perioperative use is relatively safe.. Methods for assessment pain in veterinary are adaptations of scales used in human pain measurement. The most currently used are the simple descriptive scale, numerical rating scale and visual analogue scale. Pain score is based on subjective behavioral observation.. Multiparametrics scales, using different variables, try to minimize subjectivity of observer. The objective of this study is to determinate effectiveness of the carprofen in the control of postoperative immediate pain in dogs using a multiparametric scale.. MATERIALS. Dogs undergoing surgery were allocated by random draw into 3 groups: group A: 5 dogs given carprofen (4 mg/kg) prior surgery and saline (0.9% NaCl) solution after surgery, group B: 5 dogs given saline solution prior surgery and carprofen after surgery, group C: 5 dogs given saline solution ...
Alfa Chemistry is the worlds leading provider for special chemicals. We offer qualified products for 116989-96-9(6H-Indolo[2,3-b]quinoxaline-6-aceticacid, 2-(1-phenylethylidene)hydrazide),please inquire us for 116989-96-9(6H-Indolo[2,3-b]quinoxaline-6-aceticacid, 2-(1-phenylethylidene)hydrazide).
Coreg Cost carvedilol 12.5 mg tab teva carvedilol vr carvedilol fosfato coreg 100 mg carvedilol cost without insurance generic coreg cr 20 mg buy corega denture adhesive.Cr 20 mg generic name zyprexa price comparison coreg 7295 sales.Buy cr have here in usa 6.25 mg carvedilol lp 40 carvedilol 3.125mg price fosfato 40 mg precio.Find patient medical information for Coreg CR oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings.. Coreg CR is a brand name of carvedilol, approved by the FDA in the following formulation(s).Cheap Coreg Online, Can Carvedilol Have The Opposite Effect Carvedilol Cost when will coreg cr become generic coreg cr 40 coupon carvedilol 5 mg cost.Revenue - Coreg CR data for GlaxoSmithKline: industry ranking, historical trend, and competitor comparison.Learn about the prescription medication Coreg (Carvedilol), drug uses, dosage, side effects, drug interactions, warnings, reviews and patient labeling.Generic problems ...
Actually, considerable heterogeneity in, eg, pharmacokinetic, pharmacological, and physicochemical properties exists across the completely different courses of β-blockers, particularly between the second-generation and newer third-technology brokers. Carvedilol is a vasodilating noncardioselective third-technology β-blocker, without the unfavorable hemodynamic and metabolic effects of conventional β-blockers, which can be used as a cardioprotective agent. Compared with conventional β-blockers, carvedilol maintains cardiac output, has a reduced prolonged impact on coronary heart rate, and reduces blood stress by decreasing vascular resistance. Studies have additionally shown that carvedilol displays favorable effects on metabolic parameters, eg, glycemic management, insulin sensitivity, and lipid metabolism, suggesting that it could be thought of in the treatment of patients with metabolic syndrome or diabetes. Prior to drug initiation, stabilize hemodynamics and minimize fluid retention. ...
carvedilol order online carvedilol no prescription carvedilol online pharmacy buy carvedilol tablet online You need to get used to this medication, but it is really very effective. It has in fact save
Product Name: 5,7-Dihydro-7,7-dimethyl-indenocarbazoleFormula: C21H17NWeight: 283.36638SMILES: C1C=C2C(=CC=1)C3=C(N2)C=C4C(C)(C)C5C(=CC=CC=5)C4=C3CAS NO:
We examined in vivo FLT3 inhibition in AML patients treated with chemotherapy followed by the FLT3 inhibitor lestaurtinib, comparing newly-diagnosed AML patients with relapsed patients. Because we noted that in vivo FLT3 inhibition by lestaurtinib was less effective in the relapsed patients compared with the newly-diagnosed patients, we investigated whether plasma FLT3 ligand (FL) levels could influence the efficacy of FLT3 inhibition in these patients. Following intensive chemotherapy, FL levels rose to a mean of 488 pg/mL on day 15 of induction therapy for newly-diagnosed patients, while they rose to a mean of 1148 pg/mL in the relapsed patients. FL levels rose even higher with successive courses of chemotherapy, to a mean of 3251 pg/mL after the fourth course. In vitro, exogenous FL at concentrations similar to those observed in patients mitigated FLT3 inhibition and cytotoxicity for each of 5 different FLT3 inhibitors (lestaurtinib, midostaurin, sorafenib, KW-2449, and AC220). The dramatic ...
The present invention relates to carvedilol phosphate salts, which include novel crystalline forms of carvedilol dihydrogen phosphate (i.e., dihydrogen phosphate salt of 1-(carbazol-4-yloxy-3-[[2-(o-methoxyphenoxy) ethyl]amino]-2-propanol) and/or carvedilol hydrogen phosphate, etc.), and/or solvates thereof, compositions containing the aforementioned salts and/or solvates, and methods of using the aforementioned salts and/or solvates to treat hypertension, congestive heart failure and angina, etc.
The present invention relates to carvedilol phosphate salts, which include novel crystalline forms of carvedilol dihydrogen phosphate (i.e., dihydrogen phosphate salt of 1-(carbazol-4-yloxy-3-[[2-(o-methoxyphenoxy) ethyl]amino]-2-propanol) and/or carvedilol hydrogen phosphate, etc.), and/or solvates thereof, compositions containing the aforementioned salts and/or solvates, and methods of using the aforementioned salts and/or solvates to treat hypertension, congestive heart failure and angina, etc.
TY - JOUR. T1 - Carvedilol, a pharmacological antioxidant, inhibits neointimal matrix metalloproteinase-2 and -9 in experimental atherosclerosis. AU - Wu, Tao Cheng. AU - Chen, Yung Hsiang. AU - Leu, Hsin Bang. AU - Chen, Yuh Lien. AU - Lin, Feng Yen. AU - Lin, Shing Jong. AU - Chen, Jaw Wen. PY - 2007/12/1. Y1 - 2007/12/1. N2 - Matrix metalloproteinase (MMP) is critical to the progression of atherosclerosis and neointima hyperplasia after vascular injury. We investigated the effects of carvedilol, a pharmacological antioxidant with α- and β-adrenergic blocking activity, on MMP-2 and MMP-9 expression. Vascular injury was induced with the balloon catheters on abdominal aortas of high-cholesterol-fed rabbits. On Day 21, there was significant aortic neointima formation with increased oxidative DNA damage by immunostaining with 8-hydroxy-2′-deoxyguanosine and enhanced MMP-2 and MMP-9 expressions by Western blotting, which were significantly reduced by oral administration of carvedilol (20 ...
Results Screening At SJCRH, screening of about 3,800 FDA accredited medication together with other bio actives recognized 24 compounds with EC50 values 1 uM. Of those, 19 had acknowledged pharmacokinetic and or security profiles that had been deemed unsuitable for development as an oral anti malarial drug. In the other compounds, two are available only for topical external use, pravastatin cant be used in pregnancy, and sulphamerazine is actually a sulphonamide a class of molecule that has already yielded anti malarial medication, though P. falciparum has formulated resistance to your compounds which are utilised clinically. Lestaurtinib is really a protein kinase inhibitor in development by Cephalon Inc for acute myelogenous leukaemia and myeloprolifera tive problems. Clinical facts on this compound was limited on the time from the study and protein kinase inhibi tors are suggested as an essential target in malaria. So, only lestaurtinib was progressed to the P. falciparum HuSCID mouse model. ...
Carvedilol price - even hold a poll, and that the president basically endorsed clinton for the whole nea and everyone in it is pissed.
Carvedilol is a medicine available in a number of countries worldwide. A list of US medications equivalent to Carvedilol is available on the Drugs.com website.
Could Carvedilol cause Poisoning? We studied 42,470 Carvedilol users who have side effects from FDA and eHealthme. Among them, 43 have Poisoning. See what we found.
Order Coreg online - Can I Order Carvedilol Without Prescription Genuine Coreg To Buy. Buy Coreg Winston-Salem Order Cheap Coreg 6.25mg Tags: carvedilol, coreg.
VetDepot offers Vetprofen (carprofen) 100 mg, 240 Caplets at the most competitive prices. Get the best deals on all your pet meds at VetDepot. Vetprofen (carprofen) is an NSAID pain medication indicated for the relief of pain and inflammation associated with osteoarthritis.
Quellin Carprofen Soft Chew - Generic to Rimadyl 100 mg chewables 60 ct by BAYER for only $74.96. Find out more about Quellin Carprofen Soft Chew - Generic to Rimadyl 100 mg chewables 60 ct by BAYER and check out opinions from other buyers. Discounts, deals, special offers for Pet Supply on ShopMania.
The Dropship Medicines is a high quality exporter and supplier of Pharmcy Medicines.We are provided generic pharmacy wholesale, Medicine Dropshipper.Generic Coreg (Carvedilol)Coreg is is a beta blocker applied in treatment of heart failure and hypertension (high blood pressure).
BUY ORDER Coreg (Carvedilol) cheap discount online for sale price cost 25 mg/12,5 mg/6,25 mg/3,12 mg Coreg is used to treat high blood pressure, heart failure and after a heart attack to improve the chance of survival.
BUY Coreg ONLINE (Carvedilol) 25 mg/12,5 mg/6,25 mg/3,12 mg UK for sale discount price order get cheap purchase Coreg is used to treat high blood pressure, heart failure and after a heart attack to improve the chance of survival.
Heart Disease - Cavelon (Brand name: coreg) Carvedilol, Acridilole,Adacor,Anisto,Antibloc,Artione,Artist,Atenote,Atram,Avedol,Avernol,Betacar,Betaplex,Bidecar,Biocard,Blocar,Bloquedil,Blorec,Cadalol,Cadil,Caravel,Carbatil,Carbloxal,Carca,Cardigard,Cardilol,Cardiol,Cardix,Carlatrend,Carlich,Carloc,Carve-q,Carved,Carvedexxon,Carvedigamma,Carvedil,Carvedilen,Carvedilolum,Carveditas,Carvelol,Carvepen,Carveratio,Carvestad,Carvetrend,Carvewin,Carvexal,Carvid,Carvida,Carvidil,Carvidol,Carvil,Carvilar,Carvilex,Carviloc,Carvipress,Carvo,Carvol,Carvédilol,Cavelon,Cavepia,Co-dilatrend,Colver,Conpres,Corafen,Corel,Coritensil,Coronis,Coropres,Cortop,Corubin,Coryol,Coventrol,Curcix,Dilapress,Dilasig,Dilatrend,Dilbloc,Dilol,Dimetil,Dimitone,Diola,Divelol,Dualten,Duobloc,Durol,Eucardic,Eucor,Filten,Hipoten,Hypoten,Isobloc,Karvedil,Karvedilol,Karvidil,Karvil,Karvileks,Kinetra,Kredex,Lodipres,Longcardio,Milenol,Nicorax,Off-ten,Omeria,Palacimol,Querto,Raserbloc,Rudoxil,Symtrend,Syntrend,Talliton,Trakor,Ucardol,Vasodyl,V
Heart Disease - Artione (Brand name: coreg) Carvedilol, Acridilole,Adacor,Anisto,Antibloc,Artione,Artist,Atenote,Atram,Avedol,Avernol,Betacar,Betaplex,Bidecar,Biocard,Blocar,Bloquedil,Blorec,Cadalol,Cadil,Caravel,Carbatil,Carbloxal,Carca,Cardigard,Cardilol,Cardiol,Cardix,Carlatrend,Carlich,Carloc,Carve-q,Carved,Carvedexxon,Carvedigamma,Carvedil,Carvedilen,Carvedilolum,Carveditas,Carvelol,Carvepen,Carveratio,Carvestad,Carvetrend,Carvewin,Carvexal,Carvid,Carvida,Carvidil,Carvidol,Carvil,Carvilar,Carvilex,Carviloc,Carvipress,Carvo,Carvol,Carvédilol,Cavelon,Cavepia,Co-dilatrend,Colver,Conpres,Corafen,Corel,Coritensil,Coronis,Coropres,Cortop,Corubin,Coryol,Coventrol,Curcix,Dilapress,Dilasig,Dilatrend,Dilbloc,Dilol,Dimetil,Dimitone,Diola,Divelol,Dualten,Duobloc,Durol,Eucardic,Eucor,Filten,Hipoten,Hypoten,Isobloc,Karvedil,Karvedilol,Karvidil,Karvil,Karvileks,Kinetra,Kredex,Lodipres,Longcardio,Milenol,Nicorax,Off-ten,Omeria,Palacimol,Querto,Raserbloc,Rudoxil,Symtrend,Syntrend,Talliton,Trakor,Ucardol,Vasodyl,V
Your doctor may need to lower your dosage or temporarily stop carvedilol if this. and beautify hair dates back to the Heian Period in
Find here the secondary pharmaceutical standard of the native API Carvedilol traceable to USP and PhEur.
Putney Carprofen Caplets are indicated for the relief of pain and inflammation associated with osteoarthritis and for the control of postoperative pain associated with soft tissue and orthopedic surgeries in dogs.
Putney Carprofen Caplets are indicated for the relief of pain and inflammation associated with osteoarthritis and for the control of postoperative pain associated with soft tissue and orthopedic surgeries in dogs.
Learn about Carprofen Caplets for animal usage including: active ingredients, directions for use, precautions, and storage information.
Application of Japp-Klingemann Reaction in the synthesis of Carbazoles and Azacarbazole derivatives: Synthesis of 1,8-disubstituted-2,3-dihydro-1H-pyrido[3,2-b]indol-4-(5H)-ones from aryl amines ...
ATLANTA - An investigational oral targeted agent called lestaurtinib (CEP-701), a FLT3 kinase inhibitor, can enhance the likelihood of complete remissions, compared with chemotherapy alone, for poor-p
If you enjoy sports or any other athletic exercise, there is one opponent that always wins. Father time is the true champion of everything. Lets face it,
Porphyrins are tetrapyrrolic aromatic macrocycles and ubiquitous in nature. They are excellent dyes with strong absorption in the visible region (400�700 nm) and they exhibit decent fluorescence in the red region (620�900 nm). Carbazole is a nitrogen-containing electron rich aromatic heterocycle which can be linked to porphyrins and other chromophores. This review provides an overview of the different synthetic strategies that have been employed to prepare carbazole-substituted porphyrins and carbazole-fused porphyrinoids and similar systems. It also shows that how the substitution of carbazole occurs on the porphyrin core can alter its optical and electronic features. Introduction of carbazole moieties in the porphyrin ring resulted in fused porphyrinoids with changed aromaticity and significantly altered electronic features of the molecules ...
HAMERTON, I, PIELICHOWSKI, J and PIELICHOWSKI, K (1994) A STUDY OF THE THERMAL-DEGRADATION OF POLY(VINYL CHLORIDE) IN THE PRESENCE OF CARBAZOLE AND POTASSIUM CARBAZOLE USING TGA/FTIR ...
The findings of the present study indicate that, in addition to prolonging survival, carvedilol ameliorates the morbidity of patients with severe chronic heart failure when assessed by both patients and physicians. During long-term treatment, carvedilol-treated patients were more likely to feel better and less likely to feel worse than patients in the placebo group. This symptomatic benefit was apparent even though all patients had had symptoms at the start of the study that had been refractory to conventional therapy for heart failure. At the same time, carvedilol markedly reduced the risk of clinical deterioration, as reflected by physician reports of the occurrence of hospitalization or a serious adverse event. Carvedilol reduced the combined risk of death or hospitalization for heart failure by 31%, of death or cardiovascular hospitalization by 27%, and of death or hospitalization for any reason by 24%. Fewer patients in the carvedilol group than in the placebo group were hospitalized for ...
Structure, properties, spectra, suppliers and links for: 12-(2-Cyanoethyl)-6,7,12,13-tetrahydro-13-methyl-5-oxo-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole.
TY - JOUR. T1 - Cyclizative Condensations. IV. 3,3′ Alkylidenebisindoles from Methyl Ketones and Their Conversion to Indolo[2,3-bjcarbazoles. AU - Noland, Wayland E. AU - Venkiteswaran, M. R.. PY - 1961/11. Y1 - 1961/11. N2 - Condensation of acetone with 5-methylindole and 5-benzyloxyindole in refluxing acetic acid gave the bisindoles Ie and If. Similarly, condensation of acetophenone with indole, 1-methylindole, and 2-methylindole gave the corresponding bisindoles Ih, Ii, and IXc. Condensation of acetone with indole or with the corresponding bisindole (Id) in refluxing maleic acid solution gave the indolo[2,3-b]carbazole IIf, while the corresponding condensation of acetone with the bisindole (Ie) from 5-methylindole gave the indolo [2,3-b] carbazole IIg. Condensation of acetone with 1-methylindole or with the corresponding bisindole (Ig) in ethanolic hydrochloric acid gave the indolo [2,3-b] carbazole IIh. Condensation of indole with acetophenone in ethanolic hydrochloric acid gave the ...
A process for the preparation of carvedilol of formula (I) (I) either in enantiomeric substantially pure form, or as an enantiomeric mixture, optionally as a pharmaceutically acceptable salt thereof, which process comprises reacting 2,3-eopxypropoxy carbazole of formula (II) (II) or the R or S enantiomer thereof, with N-[2-(2-methoxy-phenoxy)ethyl]-benzylamine of formula (V) (V) to yield benzyl carvedilol of formula (VI) (VI) which is debenzylated by catalytic hydrogenation to yield carvedilol of formula (I), either in enantiomeric substantially pure form, or as an enantiomeric mixture, and if desired reacting the thus formed carvedilol of formula (I) with an inorganic or organic acid to yield a pharmaceutically acceptable salt thereof, and/or, if desired, separating the enantiomers. The above process is characterised in that reaction of said 2,3-epoxypropoxy carbazole of formula (II) with said N-[2-(2-methoxy-phenoxy)ethyl]-benzylamine of formula (V) is carried out in water as the reaction ...
Analysis of compounds present in complex matrices is always a challenge, which can be partly overcome by applying various sample preparation techniques prior to detection. Ideally, the extraction techniques should be as selective as possible, to minimize the concentration of interfering substances. In addition, results can be improved by efficient chromatographic separation of the sample components. The elimination of interfering substances is especially important when utilizing mass spectrometry (MS) as a detection technique since they influence the ionization yields. It is also important to optimize ionization methods in order to minimize detection limits.. In the work this thesis is based upon, selective solid phase extraction (SPE) materials, a restricted access material (RAM) and graphitized carbon black (GCB) were employed for clean up and/or pre-concentration of analytes in plasma, urine and agricultural drainage water prior to liquid chromatography/mass spectrometry (LC/MS). Two SPE ...
A total of 6,975 patients with mild to severe heart failure were evaluated in placebo-controlled studies of carvedilol. Mild-to-Moderate Heart Failure: Carvedilol was studied in 5 multicenter, placebo-controlled studies, and in 1 active-controlled study (COMET study) involving patients with mild-to-moderate heart failure. Four US multicenter, double-blind, placebo-controlled studies enrolled 1,094 patients (696 randomized to carvedilol) with NYHA class II-III heart failure and ejection fraction ≤ 0.35. The vast majority were on digitalis, diuretics, and an ACE inhibitor at study entry. Patients were assigned to the studies based upon exercise ability. An Australia-New Zealand double-blind, placebo-controlled study enrolled 415 patients (half randomized to carvedilol) with less severe heart failure. All protocols excluded patients expected to undergo cardiac transplantation during the 7.5 to 15 months of double-blind follow-up. All randomized patients had tolerated a 2-week course on carvedilol ...
Looking for online definition of carvedilol phosphate in the Medical Dictionary? carvedilol phosphate explanation free. What is carvedilol phosphate? Meaning of carvedilol phosphate medical term. What does carvedilol phosphate mean?
BACKGROUND Beta-blockers improve left ventricular (LV) systolic function and prognosis in patients with chronic heart failure. Both carvedilol and nebivolol have hemodynamic and clinical benefits in chronic heart failure (CHF), but it is unknown whether their pleiotropic properties may play a role in different subgroups of patients with CHF.. OBJECTIVE: To compare the effects of nebivolol and carvedilol on LV function and clinical outcome in patients with chronic heart failure and reduced LV systolic function.. METHODS: 160 hypertensive CHF patients, LV ejection fraction (EF) 40% and in New York Heart Association (NYHA) functional class II or III were randomly assigned to receive carvedilol or nebivolol therapy for 24 months. At baseline and after 24 months of treatment, all patients underwent clinical evaluation: echocardiogram and 6-minute walking test. ...
Postfunctionalization of Alkyne-Linked Conjugated Carbazole Polymer by Thermal Addition Reaction of Tetracyanoethylene. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
Rats undergoing laparotomy received either carprofen (5 mg/kg) or ketoprofen (5 mg/kg) administered orally in flavoured gelatin, or by subcutaneous injection. A control group that received no analgesic showed a significant (3 per cent) fall in bodyweight (P=0.009) after laparotomy. This decrease was greater than that seen in the groups receiving carprofen (P=006) or ketoprofen (Pd=0012) administered subcutaneously, which continued to gain weight following surgery. All animals showed a significant fall in food consumption but this decrease was greater in the jelly alone group (47 per cent) than in the group receiving carprofen (17 per cent) (P=0.015) administered subcutaneously. A significant fall in water consumption occurred in the control group (40 per cent) and in animals that received oral carprofen (13 per cent) or ketoprofen (22 per cent). No significant decrease was seen in groups receiving either carprofen or ketoprofen administered subcutaneously (P,0.1). This study shows that a ...
Carvedilol - Get up-to-date information on Carvedilol side effects, uses, dosage, overdose, pregnancy, alcohol and more. Learn more about Carvedilol
Measures of interest included hospitalization frequency, numbers of hospital days in special-care units (e.g., ICU/CCU) and overall, utilization of selected cardiovascular procedures, and costs of cardiovascular-related in-patient care. A cost was assigned to each cardiovascular hospitalization using cost-prediction models that were estimated using a large database containing admission-level information from 153 U.S. short-term, acute-care hospitals (HCIA, Inc.) (22). Data available for each hospital discharge included all International Classification of Diseases, Ninth Revision (ICD-9-CM) diagnoses and procedure codes, time spent in various units (e.g., ICU/CCU), services used, and total hospitalization cost. Four distinct models were developed, corresponding to the four cardiovascular primary admission causes designated on the study case-report form.. To select a master sample of hospital admissions for model estimation, all hospital stays in the HCIA database with a listed principalor ...
A process for the preparation of 6-chloro-.alpha.-methylcarbazole-2-acetic acid from 6-chloro-.alpha.-hydroxy-.alpha.-methylcarbazole-2-acetic acid and/or 6-chloro-.alpha.-methylene-2-carboxylic acid, is described. The preparation of intermediates, such as, 6-chloro-.alpha.-hydroxy-.alpha.-methylcarbazole-2-acetic acid and lower alkyl carbazole-2-oxalate, inter alia, is also described.
Pregnancy Category C. Studies performed in pregnant rats and rabbits given carvedilol revealed increased post-implantation loss in rats at doses of 300 mg per kg per day (50 times the maximum recommended human dose [MRHD] as mg per m2) and in rabbits at doses of 75 mg per kg per day (25 times the MRHD as mg per m2). In the rats, there was also a decrease in fetal body weight at the maternally toxic dose of 300 mg per kg per day (50 times the MRHD as mg per m2), which was accompanied by an elevation in the frequency of fetuses with delayed skeletal development (missing or stunted 13th rib). In rats the no-observed-effect level for developmental toxicity was 60 mg per kg per day (10 times the MRHD as mg per m2); in rabbits it was 15 mg per kg per day (5 times the MRHD as mg per m2). There are no adequate and well-controlled studies in pregnant women. Carvedilol should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. ...
Influence of carvedilol on hospitalizations in heart failure: indicence, resource utilization and costs. U.S. Carvedilol Heart Failure Study Group ...
Manzamine A is a vacuolar ATPase uncoupler and GSK-3 inhibitor found in marine sponges. It inhibits autophagy and tumor growth in cancer models, suppresses foam cell formation in macrophages, prevents growth of gram positive and gram negative bacteria, and decreases tau hyperphosphorylation.
The synthesis of stable blue TADF emitters and the corresponding matrix materials is one of the biggest challenges in the development of novel OLED materials. We present six bipolar host materials based on triazine as an acceptor and two types of donors, namely, carbazole, and acridine. Using a tool box approach, the chemical structure of the materials is changed in a systematic way. Both the carbazole and acridine donor are connected to the triazine acceptor via a para- or a meta-linked phenyl ring or are linked directly to each other. The photophysics of the materials has been investigated in detail by absorption-, fluorescence-, and phosphorescence spectroscopy in solution. In addition, a number of DFT calculations have been made which result in a deeper understanding of the photophysics. The presence of a phenyl bridge between donor and acceptor cores leads to a considerable decrease of the triplet energy due to extension of the overlap electron and hole orbitals over the triazine-phenyl core of the
This invention relates to carvedilol methanesulfonate, compositions containing this compound and methods of using carvedilol methanesulfonate to treat hypertension, congestive heart failure and angina.
Buy Novox 100 mg, 60 Chewable Tablets (Carprofen) at VetDepot. Get the best prices on discount Novox 100 mg, 60 Chewable Tablets (Carprofen).
Until now, there has been no appropriate marker to specifically and effectively label living neural stem/precursor cells (NSPCs) to investigate NSPC migration and differentiation. Therefore, the purpose of this study was to develop a specific method for tracking NSPCs by a cell marker, 3,6-bis(1-methyl-4-vinylpyridinium)-carbazole diiodide (BMVC). It was found that the bright fluorescence spots co ...
Frova (Frovatriptan Succinate) may treat, side effects, dosage, drug interactions, warnings, patient labeling, reviews, and related medications including drug comparison and health resources.
Are you looking to get Frova online safely? KamaHalth provides top quality of Frova (Frovatriptan succinate) and other prescription medications in an affordable and safe manner.
The IUPHAR/BPS Guide to Pharmacology. carprofen ligand page. Quantitative data and detailed annnotation of the targets of licensed and experimental drugs.
Donor-Acceptor (D-π-A) type carbazole-porphyrin dyads and triads were synthesized in good yields through palladium catalyzed coupling reactions. The length of the spacer between the D (carbazole) and A (porphyrin) was ...
This study shows a molecular design strategy for controlling the dihedral angle of two carbazole donors linked to a 2,4-diphenyl-1,3,5-triazine acceptor by a ...
Apo-Carvedilol: Carvedilol belongs to the class of medications called beta-blockers. Carvedilol is used to treat congestive heart failure (CHF), including severe heart failure. It is often taken with a diuretic (water pill) and an angiotensin converting enzyme (ACE) inhibitor.
ratio-Carvedilol: Carvedilol belongs to the class of medications called beta-blockers. Carvedilol is used to treat congestive heart failure (CHF), including severe heart failure. It is often taken with a diuretic (water pill) and an angiotensin converting enzyme (ACE) inhibitor.
Buy KT 5823 - an affordable, high quality PKG Inhibitor from Hello Bio, a trusted supplier for life science researchers worldwide
Indikasjoner:Behandling av essensiell hypertensjon og kronisk stabil angina pectoris. Tilleggsbehandling ved moderat til alvorlig stabil hjertesvikt i
And we were able to significantly reduce net financial debt to EUR 0. Carvedilol counter cod next day buy carvedilol internet. Generic Viagra impotence
Indikasjoner:Behandling av essensiell hypertensjon og kronisk stabil angina pectoris. Tilleggsbehandling ved moderat til alvorlig stabil hjertesvikt i
Discount Pet Prescriptions from Australian Pharmacists. Leading Pet Pharmacy selling discount pet medicines like Vetmedin, Fortekor and Caninsulin.
Victor Mair, "Wait Till You Hear a Weak Pyridaben Carbazole Sound", Language Log, 30 June 2010. Victor Mair, "4 Uygur Theater ... carbazole'). 4 Uygur theater is printed on the bilingual instructions for a Chinese 4-D film about dinosaurs. The Chinese term ... pyridaben carbazole' sound the installation is completed." The original Chinese has an onomatopoetic term dādā kǎzuò (噠噠咔唑; ' ... pyridaben carbazole' sound is found on translated instructions for a photographic light, "Install the battery into the battery ...
Likewise, the compounds with two benzene rings fused to the central heterocycle are carbazole, acridine, and dibenzoazepine. ... carbazole, and dibenzofuran. The unsaturated rings can be classified according to the participation of the heteroatom in the ...
Reaction of naphtols and hydrazines and sodium bisulfite in the Bucherer carbazole synthesis ...
An example of using exciplex is grafting Oxadiazole and carbazole side units in red diketopyrrolopyrrole-doped Copolymer main ... Carbazole cations". Polymer. 24 (6): 733-738. doi:10.1016/0032-3861(83)90012-5. Partridge, R (1983). "Electroluminescence from ... "Enhancement of Electroluminescence Properties of Red Diketopyrrolopyrrole-Doped Copolymers by Oxadiazole and Carbazole Units as ...
Roth, Lepke (1972). "Synthese von Indol- und Carbazol-Derivaten aus α-Hydroxyketonen und aromatischen Aminen" [Synthesis of ... indole and carbazole derivatives from α-hydroxyketones and aromatic amines]. Archiv der Pharmazie (in German). 305 (3): 159-171 ...
It is produced by the vinylation of carbazole with acetylene in the presence of base. Carbazole Lide, David R. (2008). CRC ...
Common impurities are phenanthrene and carbazole. The mineral form of anthracene is called freitalite and is related to a coal ...
This enzyme participates in carbazole degradation. It employs one cofactor, FAD. Buder R, Fuchs G (1989). "2-Aminobenzoyl-CoA ...
P. resinovorans, which can degrade carbazole. P. veronii, which has been shown to degrade a variety of simple aromatic organic ... 2002). "Organization and transcriptional characterization of catechol degradation genes involved in carbazole degradation by ...
2002). "Organization and transcriptional characterization of catechol degradation genes involved in carbazole degradation by ...
Some species also contain the carbazole girinimbine. M. koenigii has yielded a vast array of compounds, including carbazoles ...
9) Cyclization of arylvinyl- or diarylamines provides indolines and carbazoles, respectively. In one interesting example, the ...
... carbazoles are the Indolo(2,3-a)pyrrole(3,4-c)carbazoles. These can be divided into two major classes - halogenated ( ... The most frequently isolated indolocarbazoles are Indolo(2,3-a)carbazoles; the most common subgroup of the Indolo(2,3-a) ... carbazoles and preparation of various functionalized derivatives". J. Org. Chem. 72 (19): 7207-7213. doi:10.1021/jo0711337. ... carbazole by palladium(0) catalyzed polyannulation". Tetrahedron Lett. 36 (43): 7841-7844. doi:10.1016/0040-4039(95)01644-w.CS1 ...
... is the central step in Borsche-Drechsel carbazole synthesis, where in the first step ... Bucherer carbazole synthesis Fischer indole synthesis E. Drechsel (1888). "Ueber Elektrolyse des Phenols mit Wechselströmen". J ... and in the final step the resulting tetrahydrocarbazole is oxidized to carbazole itself. The reaction has been described in the ...
... has the ability to degrade dibenzofuran and carbazole. LPSN lpsn.dsmz.de Straininfo of ...
228-767-9, CAS RN 6358-30-1) which differ in terms of the carbazole ring fusion. Pigment violet 23 is prepared by condensation ... It is member of the dioxazine family of heterocyclic compounds, but derived from carbazoles. It is prepared by condensation of ...
doi:10.15227/orgsyn.084.0163.Wei Zhang; Hyeon Mo Cho; Jeffrey S. Moore (2007). "Preparation of a Carbazole-Based Macrocycle via ...
This enzyme participates in benzoate degradation via hydroxylation and carbazole degradation. Rao PV, Moore K, Towers GH (1967 ...
Caffeine Cantharidin Captan Carbaryl Carbazole 3-Carbethoxypsoralen Carmoisine Carrageenan Chloral Chloral hydrate Chloramine ...
Halogenated indolo(2,3-a)pyrrole(3,4-c)carbazoles have a fully oxidized C-7 carbon with only one indole nitrogen containing a β ... Of these, Staurosporine falls within the most common subgroup, called Indolo(2,3-a)pyrrole(3,4-c)carbazoles. These fall into ... It belongs to the most frequently isolated group of indolocarbazoles: Indolo(2,3-a)carbazoles. ... bond, while non-halogenated indolo(2,3-a)pyrrole(3,4-c)carbazoles have both indole nitrogens glycosylated, and a fully reduced ...
"Dicyanovinylene carbazole based A-D-A type small molecules for organic solar cell applications" Communicated in Synthetic ... E. K. T. Sivakumar, Sathiyan G, Ganesamoorthy R, Thangamuthu R and Sakthivel P. "Synthesis and studies of carbazole based (A-D- ... "Synthesis and Studies of Carbazole Based (A-D-A) Polymers For Organic Solar Cell Applications" International conference on ... "Synthesis and characterization of fluorescence poly(carbazole-thiazolo[5,4-d]thiazole) copolymer and effect of different ...
Carbazole can be denitrogenated by hydrogen to yield bicyclohexyl as the main product. When cyclohexane is exposed to radiation ...
doi:10.1021/ed077p1644 Carbazol-9-yl-methanol Milata Viktora, Kada Rudolfa, Lokaj J¨¢nb Molbank 2004, M354 open access ... Illustrative is the reaction of the weakly basic secondary amine carbazole with formaldehyde. As is typical with a secondary ... amine derivative, this carbinol converts readily to the methylene-linked bis(carbazole). Ammonia adds to hexafluoroacetone to ...
reported a series of polymethylacrylate compounds containing lateral brominated and iodinated carbazole rings. They had ...
The reaction is summarized as follows: The Bucherer carbazole synthesis is a related reaction. H. Bucherer (1904). "Über die ...
It is able to degrade carbazole, and as such, may be used in bioremediation. Based on 16S rRNA analysis, P. resinovorans has ... "Organization and transcriptional characterization of catechol degradation genes involved in carbazole degradation by ...
Indoline Indole Indene Benzofuran Isoindoline Carboline Isatin Methylindole Carbazole Pyrrole Skatole Benzene Riggio, Oliviero ...
... carbazoles from 2-(Benzotriazol-1-ylmethyl)indole". J. Org. Chem. 60 (11): 3401-3404. doi:10.1021/jo00116a026. Lynch, S. M.; ...
... carbazole-dithiophene-benzothiadiazole (PCDTBT) family. For solar cell applications they can be blended with C60 or PCBM as ... carbazoles, and phthalocyanine. Molecularly doped polymers are prepared by spreading a film of an electrically inert polymer, e ...
... carbazole degradation, and nitrogen metabolism. Powlowski JB, Dagley S, Massey V, Ballou DP (1987). "Properties of anthranilate ...
Polychlorinated carbazoles (PCCZ) are a group of chlorinated organic compounds. They are derivatives of carbazole and nitrogen ... In environmental samples, mixed halogenated carbazoles are also found. Juliane Kirst: Synthesis of polyhalogenated carbazoles ... Polychlorinated carbazoles usually occur as a mixture of various isomers. This mixture can have a certain frequency pattern ( ... J. Guo, D. Chen, D. Potter, K. J. Rockne, N. C. Sturchio, J. P. Giesy, A. Li: Polyhalogenated Carbazoles in Sediments of Lake ...
In the third step, this compound is oxidized by red lead to carbazole itself. Another classic is the Bucherer carbazole ... Carbazole is a constituent of tobacco smoke. A classic laboratory organic synthesis for carbazole is the Borsche-Drechsel ... Carbazole is an aromatic heterocyclic organic compound. It has a tricyclic structure, consisting of two six-membered benzene ... A third method for the synthesis of carbazole is the Graebe-Ullmann reaction. In the first step, an N-phenyl-1,2-diaminobenzene ...
The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. However, NIST makes no warranties to that effect, and NIST shall not be liable for any damage that may result from errors or omissions in the Database ...
Two azacrown derivatives of carbazole have been prepared and their dipole moments in the excited state were estimated from ... Fluorescence Spectrum Perchlorate Oxidation Peak Carbazole Oxidation Potential These keywords were added by machine and not by ... Two azacrown derivatives of carbazole have been prepared and their dipole moments in the excited state were estimated from ... From the study of the longer lived radical-cation of the azacrown carbazoles, generated electrochemically, the metal cations ...
Carbazole; Refer to the product ′s Certificate of Analysis for more information on a suitable instrument technique. Contact ... Carbazoles belong to the family of polycyclic aromatic hydrocarbons (PAHs) compounds. Application Carbazole may be used as a ... reference standard for the determination of carbazole in:. • e-cigarette aerosols by thermal desorption-gas chromatography- ...
... Kazuhiro Nakabayashi and Hideharu ... Kazuhiro Nakabayashi and Hideharu Mori, "Novel Complex Polymers with Carbazole Functionality by Controlled Radical ...
Get Carbazoles at Spectrum Chemical. SpectrumChemical.com carries a full line of fine chemicals, lab appliances and lab ...
2-Nitro-9H-carbazol-3-amine , C12H9N3O2 , CID 4023072 - structure, chemical names, physical and chemical properties, ...
7H-DIBENZO(c,g)CARBAZOLE. VOL.: 3 (1973) (p. 260). 5. Summary of Data Reported and Evaluation. 5.1 Animal carcinogenicity data ... 7H-Dibenzo(c,g)carbazole is carcinogenic in the mouse, rat, hamster and possibly in the dog. It has both a local and systemic ... In comparison with benzo(a)pyrene, 7H-dibenzo(c,g)carbazole appears to be a stronger respiratory tract carcinogen for the ... No case reports or epidemiological studies on the significance of 7H-dibenzo(c,g)carbazole exposure to man are available. The ...
Non-coplanar shaped carbazole based monomers were used to synthesize microporous polycarbazole materials utilizing an ... Highly selective CO2 adsorption performance of carbazole based microporous polymers M. Saleh and K. S. Kim, RSC Adv., 2015, 5, ... Non-coplanar shaped carbazole based monomers were used to synthesize microporous polycarbazole materials utilizing an ... Introduction of the electron rich carbazole structure into the aromatic system and pore geometry contribute to higher ...
Synthesis, Characterization and Photophysical Properties of Pyridine-Carbazole Acrylonitrile Derivatives by Enrique Pérez- ... "Synthesis, Characterization and Photophysical Properties of Pyridine-Carbazole Acrylonitrile Derivatives." Materials 4, no. 3: ... Characterization and Photophysical Properties of Pyridine-Carbazole Acrylonitrile Derivatives. Materials 2011, 4, 562-574. ... Characterization and Photophysical Properties of Pyridine-Carbazole Acrylonitrile Derivatives. Materials. 2011; 4(3):562-574. ...
... alkyl carbazole-2-oxalate, inter alia, is also described. ... Preparation of carbazole-2-oxalic acid methyl ester. A stirred ... Preparation of ethyl carbazole-2-oxalate. To a stirred suspension of 167.2 g. of carbazole in 400 ml. of methylene chloride was ... gave 181 g. of ethyl carbazole-2-oxalate as a gold powder, sintering at 130.degree.,m.p. 130.5-131.5.degree... EXAMPLE 2. ... In a first aspect, the invention relates to a process for preparing carbazole-2-oxalic acid lower alkyl ester by a process ...
Article Investigation of carbazole degradation by the sono-Fenton process. The present report aimed to describe the roles of ... ultrasonic power and reaction time in the Fenton reagent-based degradation of carbazole in wastewater, and to analyze the eff ... Investigation of carbazole degradation by the sono-Fenton .... Investigation of carbazole degradation by the sono-Fenton ... No comments were found for Investigation of carbazole degradation by the sono-Fenton process. Be the first to comment! ...
9H-carbazole , C18H11ClN4O2 , CID 116535 - structure, chemical names, physical and chemical properties, classification, patents ...
... is conducting an administrative review of the antidumping duty order on carbazole violet pigment 23 from India. The review ... See Carbazole Violet Pigment 23 From India: Extension of Time Limit for Preliminary Results of Antidumping Start Printed Page ... Carbazole Violet Pigment 23 from India: Preliminary Results of Antidumping Duty Administrative Review. A Notice by the ... See Carbazole Violet Pigment 23 From India: Final Results of Antidumping Duty Administrative Review, 73 FR 74141 (December 5, ...
A series of carbazole derivatives such as N-substituted carbazoles, benzocarbazoles, furocarbazoles, pyrrolocarbazoles, ... Herein an attempt is made to review the medicinal importance of recently synthesized N-substituted carbazoles. ... Carbazoles represent an important class of heterocycles. These have been reported to exhibit diverse biological activities such ... Keywords: N-substituted carbazoles; antimicrobial; anticancer; neuroprotective N-substituted carbazoles; antimicrobial; ...
... beta-carbazol-9-ylethyl)dimethyl-, dibromide including: 4 synonyms/identifiers. ... Ammonium, hexamethylenebis((beta-carbazol-9-ylethyl) dimethyl-, dibromide*Hexamethylenebis(2-carbazol-9-ylethyl) ... Ammonium, hexamethylenebis((beta-carbazol-9-ylethyl) dimethyl-, dibromide. Identifications. *CAS Number: 63982-08-1*Synonyms/ ... 1,6-Hexanediaminium, N,N-bis(2-(9H-carbazol-9-yl) ethyl)-N,N,N,N-tetramethyl-, dibromide* ...
2-hydroxy-11H-benzo[a]carbazole-3-carboxylic acid. EC / List no.: 201-529-1 CAS no.: 84-43-5 ...
... various carboline and carbazole derivatives were synthesized and biologically evaluated. β-Carboline and lactam-fused carbazole ... Structure-activity relationships of carboline and carbazole derivatives as a novel class of ATP-competitive kinesin spindle ...
where to buy 18992-68-2(1,3-Dimethyl-9H-carbazole).Also offer free database of 18992-68-2(1,3-Dimethyl-9H-carbazole) including ...
We also Provide Trading Suppliers & Manufacture for 37500-95-1 3,6-BIS(TERT-BUTYL)CARBAZOLE. ... Product Name: 3,6-BIS(TERT-BUTYL)CARBAZOLE. *Synonyms: 3,6-BIS(TERT-BUTYL)CARBAZOLE;3,6-Di-tert-butyl-9H-carbazole;3,6-Ditert- ... butyl-9H-carbazole;3,6-Di-tert-butylcarbazole;9H-Carbazole, 3,6-bis(1,1-diMethylethyl)-;3,6-Di-tert-butylcarbazole≥ 99% (GC) ... 3,6-Bis-(tert-butyl)-9H-carbazole. Cas No: 37500-95-1. No Data. No Data. No Data. Chemwill Asia Co., Ltd.. Contact Supplier ...
... carbazol-4-yl)ethyl]-N-propyl-propan-1-amine hydrochloride
... carbazole, Aryl hydrocarbon receptor ligand (CAS 172922-91-7), with ,95% purity. Join researchers using our high quality ... Functional Studies - 6-Formylindolo(3,2-b)carbazole, Aryl hydrocarbon receptor ligand (ab141631)Bunaciu et al PLoS One. 2015; ...
An atom-economical and environmentally benign approach for the synthesis of N-substituted carbazoles from analogous 2- ... When compared to known methods for the synthesis of N-substituted carbazoles from 2-amidobiaryls, this protocol is practical, ... Transition-metal-free and organic solvent-free conversion of N-substituted 2-aminobiaryls into corresponding carbazoles via ... Transition-metal-free and organic solvent-free conversion of N-substituted 2-aminobiaryls into corresponding carbazoles via ...
Market Research Report 2018 aims at providing comprehensive data on 2-trifluoromethyl-9h-carbazole market ... 2-trifluoromethyl-9h-carbazole prices in other regions. 7. 2-TRIFLUOROMETHYL-9H-CARBAZOLE END-USE SECTOR 7.1. 2-trifluoromethyl ... 2-trifluoromethyl-9h-carbazole market forecast. 6. 2-TRIFLUOROMETHYL-9H-CARBAZOLE MARKET PRICES. 6.1. 2-trifluoromethyl-9h- ... carbazole prices in Europe. 6.2. 2-trifluoromethyl-9h-carbazole prices in Asia 6.3. 2-trifluoromethyl-9h-carbazole prices in ...
Functional carbazole liquid-crystal block codendrimers with optical and electronic properties. Autor: Gracia, Ismael; Feringán ... Electrodeposition of carbazole dendrons afforded a globular supramolecular conformation in which the mesogenic molecular side ... The physical properties of the block codendrimers derived from the presence of the carbazole moiety in their structure were ... The synthesis and characterisation of a family of block codendrimers consisting of highly versatile mesogenic and carbazole- ...
CARBAZOLE (purity) - CAS Number 194-59-2 from LGC Standards. Please login or register to view prices, check availability and ...
  • Polychlorinated carbazoles (PCCZ) are a group of chlorinated organic compounds. (wikipedia.org)
  • Carbazoles belong to the family of polycyclic aromatic hydrocarbons (PAHs) compounds. (sigmaaldrich.com)
  • This compound belongs to the class of organic compounds known as carbazoles. (hmdb.ca)
  • Above mentioned compounds were synthesized by starting with carbazole and characterized by FTIR, 1 H-NMR, 13 C-NMR, MASS spectrometry and elemental analysis. (eurekaselect.com)
  • Increased death rates due to lung cancer have necessitated the search for potential novel anticancer compounds such as carbazole derivatives. (ukzn.ac.za)
  • Carbazoles are aromatic heterocyclic compounds with anticancer, antibacterial and anti-inflammatory activity. (ukzn.ac.za)
  • We reported earlier that activation of AhR by ultraviolet radiation is mediated by the chromophoric amino acid tryptophan (Trp), and we suggested that a new class of compounds derived from Trp, in particular 6-formylindolo[3,2-b]carbazole (FICZ), acts as natural high affinity ligands for this receptor. (diva-portal.org)
  • Highly fluorescent and stable carbazole-based compounds were synthesized and characterized. (bgsu.edu)
  • Similarly, highly stable composite fluorescent organic nanoparticles (CFONs) were prepared by co-reprecipitation of blue and red emitting carbazole-based organic compounds from water/tetrahydrofuran mixtures. (bgsu.edu)
  • The purpose of this work is to present the synthesis and characterization of four new COFs based on carbazoles, which are a class of compounds used to obtain conductive polymers. (oatd.org)
  • Novel diarylamino phenyl carbazole compounds are provided. (patentsencyclopedia.com)
  • By appropriately selecting the nature of the diarylamino substituent and the substitution on the carbazole nitrogen, compounds with appropriate HOMO and LUMO energies can be obtained for use as materials in a secondary hole transport layer. (patentsencyclopedia.com)
  • They are derivatives of carbazole and nitrogen analogues of polychlorinated dibenzofurans. (wikipedia.org)
  • Two azacrown derivatives of carbazole have been prepared and their dipole moments in the excited state were estimated from solvatochromism. (springer.com)
  • Abstract The postfunctionalization of the main chain alkyne moieties of carbazole containing polyarylenebutadiynylenes was attempted by using a high yielding addition reaction between electron rich alkynes and a strong acceptor molecule, tetracyanoethylene TCNE. (duhnnae.com)
  • 2. A compound in accordance with claim 1, ethyl carbazole-2-oxalate. (patentgenius.com)
  • The study investigated the ability of the novel carbazole compound (Z)-4-[9-ethyl-9aH-carbazol-3-yl) amino] pent-3-en-2-one (ECAP) to inhibit the proliferation of lung cancer cells and its mechanism of action. (ukzn.ac.za)
  • However, further investigation and characterization is required to fully understand the possible use of carbazole compound (Z)-4-[9-ethyl-9aH-carbazol-3-yl) amino] pent-3- en-2-one as potential lung cancer treatment. (ukzn.ac.za)
  • Nitin Kumar and Devender Pathak, "Design, Synthesis and Evaluation of Novel 9-substituted Carbazole Derivatives as Potential Anticancer Agents", Letters in Drug Design & Discovery (2015) 12: 760. (eurekaselect.com)
  • Another classic is the Bucherer carbazole synthesis, which uses a naphthol and an aryl hydrazine. (wikipedia.org)
  • Functional Studies - 6-Formylindolo(3,2-b)carbazole, Aryl hydrocarbon receptor ligand (ab141631) Bunaciu et al PLoS One. (abcam.com)
  • 6-Formylindolo[3,2-b]carbazole (FICZ) is a potent aryl hydrocarbon receptor (AHR) agonist that is efficiently metabolized by AHR-regulated cytochrome P4501 enzymes. (diva-portal.org)
  • Characterization of in Vitro Metabolites of the Aryl Hydrocarbon Receptor Ligand 6-Formylindolo[3,2-b]carbazole by Liquid Chromatography-Mass Spectrometry and NMR. (aspetjournals.org)
  • The tryptophan photoproduct 6-formylindolo[3,2- b ]carbazole (FICZ) exhibits the highest aryl hydrocarbon receptor (AhR) binding affinity reported so far. (aspetjournals.org)
  • The aryl hydrocarbon receptor (AhR) ligand 6-Formylindolo(3,2-b)carbazole (FICZ) has received increasing attention since its identification as an endogenous AhR ligand and a photoproduct of tryptophan. (biomedcentral.com)
  • Carbazole is an aromatic heterocyclic organic compound. (wikipedia.org)
  • The luminescence of the electron-rich carbazole adducts shows the donor-acceptor nature of the excited state. (csic.es)
  • Carbazole is a nitrogen-containing electron rich aromatic heterocycle which can be linked to porphyrins and other chromophores. (iitgn.ac.in)
  • With three carbazole units attached to the benzene ring, 1,3,5-tris(carbazol-9-yl)benzene (tCP) is electron-rich and an excellent hole-transporting layer (HTL) material. (ossila.com)
  • Kazuhiro Nakabayashi and Hideharu Mori, "Novel Complex Polymers with Carbazole Functionality by Controlled Radical Polymerization," International Journal of Polymer Science , vol. 2012, Article ID 170912, 18 pages, 2012. (hindawi.com)
  • Structure-activity relationships of carboline and carbazole derivatives as a novel class of ATP-competitive kinesin spindle protein inhibitors. (nih.gov)
  • Based on natural product scaffold-derived fused indole-based inhibitors and known biphenyl-type KSP inhibitors, various carboline and carbazole derivatives were synthesized and biologically evaluated. (nih.gov)
  • Co-crystal structures of inhibitors bound to Wee1 show that the pyrrolo[3,4-c]carbazole scaffold binds in the ATP-binding site, with N-6 substituents involved in H-bonding to conserved water molecules. (auckland.ac.nz)
  • On the other hand, the EPR parameters of these radical adducts show an imperceptible variation with the substituents in the carbazole. (csic.es)
  • Substitution of carbazoles at 3- and 6- position by tert-butyl group enhanced the solubility. (bgsu.edu)
  • The optical and electrical properties of carbazoles are affected by substitution on the 2-, 3-, 6-, 7- and 9H-positions. (bgsu.edu)
  • It also shows that how the substitution of carbazole occurs on the porphyrin core can alter its optical and electronic features. (iitgn.ac.in)
  • The compound's structure is based on the indole structure, but in which a second benzene ring is fused onto the five-membered ring at the 2-3 position of indole (equivalent to the 9a-4a double bond in carbazole, respectively). (wikipedia.org)
  • The physical properties of the block codendrimers derived from the presence of the carbazole moiety in their structure were investigated: photoluminescence in solution and in the mesophase, electrochemical behaviour and hole transport. (csic.es)
  • The presence of a carbaldehyde or malononitrile on the carbazole moiety quenches fluorescence severely in solution and in the solid state. (bgsu.edu)
  • The triazole is unstable and at elevated temperatures, nitrogen is released and the carbazole is formed. (wikipedia.org)
  • Carbazole is a heterocyclic tricyclic aromatic organic compound consisting of two six-membered benzene rings fused on either side of a five-membered nitrogen-containing ring. (bgsu.edu)
  • In the third step, this compound is oxidized by red lead to carbazole itself. (wikipedia.org)
  • 7. A compound in accordance with claim 1, carbazole-2-oxalic acid methyl ester. (patentgenius.com)
  • methylcarbazole-2-acetic acid and lower alkyl carbazole-2-oxalate, inter alia, is also described. (patentgenius.com)
  • In a first aspect, the invention relates to a process for preparing carbazole-2-oxalic acid lower alkyl ester by a process which comprises the steps of (a) acylating carbazole to yield a 9-alkanoylcarbazole, which is subsequently treated with alower alkyl oxalyl halide to yield 9-alkanoylcarbazole-2-oxalic acid lower alkyl ester and (b) deacylating the product of step (a) to yield carbazole-2-oxalic acid lower alkyl ester. (patentgenius.com)
  • 2-Methoxy-3-methyl-9H-carbazole is found in herbs and spices. (hmdb.ca)
  • 2-Methoxy-3-methyl-9H-carbazole is an alkaloid from the seeds of Murraya koenigii (curryleaf tree). (hmdb.ca)
  • 3-[(Dimethylamino)methyl]-1,2,3,9-tetrahydro-9-methyl-4H-carbazol-4-one (Ondansetron EP Impurity A) is an impurity of Ondansetron (O655000), an antiemetic. (trc-canada.com)
  • Two series i.e. 2-[(4, 5-dihydro-2-substitutedphenyl)imidazol-1-ylamino]-1-(9H-carbazol-9-yl)ethanone (3a-3e) and 2-(9H-carbazol-9-yl)-N'-{[(4-substitutedphenyl) (piperazin-1-yl)]methyl}acetohydrazide (6a-6e) were found to be potent with minimum binding energy. (eurekaselect.com)
  • Electrodeposition of carbazole dendrons afforded a globular supramolecular conformation in which the mesogenic molecular side plays a key role. (csic.es)
  • This talk will focus on strategies to modify Indium Tin Oxide (ITO) surfaces, an important substrate for display and photovoltaic devices using macromolecular grafting, layer-by-layer, and electrodeposition methods of carbazole derivatives. (aps.org)
  • A classic laboratory organic synthesis for carbazole is the Borsche-Drechsel cyclization. (wikipedia.org)
  • The reaction of o -iodoanilines or o -iodophenols with silylaryl triflates in the presence of CsF to afford N - or O -arylated products is followed by a cyclization using a Pd catalyst to carbazoles and dibenzofurans in good to excellent yields. (organic-chemistry.org)
  • Peripheral π-expansion of carbazole-based porphyrins was achieved for the first time by the Pt-catalyzed cyclization and the incorporation of a benzocarbazole unit. (elsevier.com)
  • The main building block used was 3,6-diamine-9H-carbazole with the aldehyde sources were triformylphloroglucinol, triformylphenol, 1,3,5-tri(4 formylphenyl)benzene and triformylbenzene to obtain RIO2, RIO3, RIO5 and RIO6, respectively. (oatd.org)
  • This review provides an overview of the different synthetic strategies that have been employed to prepare carbazole-substituted porphyrins and carbazole-fused porphyrinoids and similar systems. (iitgn.ac.in)
  • An atom-economical and environmentally benign approach for the synthesis of N -substituted carbazoles from analogous 2-aminobiaryls using peroxodisulfate in water is reported. (rsc.org)
  • According to this principle, a rectifying diode with hysteresis effect was fabricated utilizing a hybrid of electroactive polystyrene derivative covalently tethered with electron-donor carbazole moieties and electrostatic linked with electron-acceptor CdTe nanocrystals. (ntu.edu.sg)
  • Introduction of carbazole moieties in the porphyrin ring resulted in fused porphyrinoids with changed aromaticity and significantly altered electronic features of the molecules. (iitgn.ac.in)
  • The structures were assigned as 2- and 8-hydroxy (M3), 2,10- and 4,8-dihydroxy (M2) and 2,8-dihydroxy derivatives of indolo[3,2- b ]carbazole-6-carboxaldehyde (6-formylindolo[3,2- b ]carbazole). (aspetjournals.org)
  • Here we describe seven new FICZ-derived indolo[3,2-b]carbazole-6-carboxylic acid metabolites and two sulfoconjugates, and we demonstrate the following. (diva-portal.org)
  • The inhibition property of numerous carbazole derivatives for topoisomerase enzyme was checked by molecular docking which were designed by ChemDraw software followed by 3D optimization. (eurekaselect.com)
  • Many carbazole derivatives have sufficiently high triplet energy to make them an efficient host where they can serve as red, green, or blue triplet emitters. (bgsu.edu)
  • β-Carboline and lactam-fused carbazole derivatives exhibited remarkably potent KSP inhibitory activity and mitotic arrest in prometaphase with formation of an irregular monopolar spindle. (nih.gov)
  • This article gives a summary of our recent results in the syntheses of natural and/or biologically active molecules in aza-carbazole, naphthyridine and pyrido[ k,l ]acridine series. (ic.ac.uk)
  • 2-TRIFLUOROMETHYL-9H-CARBAZOLE (CAS 2285-35-0) Market Research Report 2018 aims at providing comprehensive data on 2-trifluoromethyl-9h-carbazole market globally and regionally (Europe, Asia, North America, Latin America etc. (marketpublishers.com)
  • Listing your company for 1,2,3,9-Tetrahydro-9[H]-Carbazole-4-One allows buyers to find your information through our directory pages which appear in the top positions when a search is conducted in Google, Yahoo! (poulvet.com)
  • Calculus based on Density Functional Theory (DFT) found that these COFs present their sheets displaced and rotated due to electrostatic interactions and to minimize the dipole moments of the N-H bonds of carbazoles. (oatd.org)
  • Simple synthetic procedures were developed to prepare other stable carbazoles. (bgsu.edu)
  • Synthetic approaches to carbazoles and 2-acylindoles [Part] II. (dartmouth.edu)
  • Mo, Lingyun: Thermodynamic Properties of Polychlorinated Carbazoles by Density Functional Theory. (wikipedia.org)
  • This is a 37ml tube of Carbazole Violet ( PV 23(RS) , Series 3). (jacksonsart.com)
  • A third method for the synthesis of carbazole is the Graebe-Ullmann reaction. (wikipedia.org)
  • Non-coplanar shaped carbazole based monomers were used to synthesize microporous polycarbazole materials utilizing an inexpensive FeCl 3 catalyzed reaction. (rsc.org)
  • The present report aimed to describe the roles of ultrasonic power and reaction time in the Fenton reagent-based degradation of carbazole in wastewater, and to analyze the effects of the Fe 2 SO 4 and H 2 O 2 concentrations and the initial pH on the reaction kinetics. (environmental-expert.com)
  • Postfunctionalization of Alkyne-Linked Conjugated Carbazole Polymer by Thermal Addition Reaction of Tetracyanoethylene - Descarga este documento en PDF. (duhnnae.com)
  • We employ the experimentally determined three dimensional (3D) structure of poly(9,9'-di-n-octylfluorene-alt-benzothiadiazole) (F8BT) to estimate the electron mobility in a similar co-alternating polymer consisting of carbazole and benzothiadiazole units (C8BT). (spie.org)
  • Effects of carbazole-degradative plasmid pCAR1 on biofilm morphology in three Pseudomonas strains. (omictools.com)
  • To elucidate the impact of the carriage of carbazole-degradative plasmid pCAR1 on biofilm formation by host bacteria, we compared biofilm morphology of pCAR1-free and pCAR1-carrying three Pseudomonas hosts: P. putida KT2440, P. aeruginosa PAO1 and P. fluorescens Pf0-1 using confocal laser scanning microscopy. (omictools.com)

No images available that match "carbazoles"