Carbazoles: Benzo-indoles similar to CARBOLINES which are pyrido-indoles. In plants, carbazoles are derived from indole and form some of the INDOLE ALKALOIDS.Sphingomonas: A genus of gram-negative, aerobic, rod-shaped bacteria characterized by an outer membrane that contains glycosphingolipids but lacks lipopolysaccharide. They have the ability to degrade a broad range of substituted aromatic compounds.Murraya: A plant genus of the family RUTACEAE. Members contain murrayanine, koenine, isomahanine, kwangsine, siamenol, murrayafoline A, murrayaquinone A and other cytotoxic carbazolequinones.Dioxygenases: Non-heme iron-containing enzymes that incorporate two atoms of OXYGEN into the substrate. They are important in biosynthesis of FLAVONOIDS; GIBBERELLINS; and HYOSCYAMINE; and for degradation of AROMATIC HYDROCARBONS.Rutaceae: A plant family in the order Sapindales that grows in warmer regions and has conspicuous flowers.Nocardiaceae: A family of gram-positive, aerobic actinomycetes found in soil and animal tissue. Some species are the cause of infection in man and animals.Ellipticines: Pyrido-CARBAZOLES originally discovered in the bark of OCHROSIA ELLIPTICA. They inhibit DNA and RNA synthesis and have immunosuppressive properties.Biodegradation, Environmental: Elimination of ENVIRONMENTAL POLLUTANTS; PESTICIDES and other waste using living organisms, usually involving intervention of environmental or sanitation engineers.Clausena: A plant genus of the family RUTACEAE. Members contain anethole and CARBAZOLES.ortho-Aminobenzoates: Benzoic acids, salts, or esters that contain an amino group attached to carbon number 2 or 6 of the benzene ring structure.Coal Tar: A by-product of the destructive distillation of coal used as a topical antieczematic. It is an antipruritic and keratoplastic agent used also in the treatment of psoriasis and other skin conditions. Occupational exposure to soots, tars, and certain mineral oils is known to be carcinogenic according to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985) (Merck Index, 11th ed).Oxygenases: Oxidases that specifically introduce DIOXYGEN-derived oxygen atoms into a variety of organic molecules.Receptors, Aryl Hydrocarbon: Cytoplasmic proteins that bind certain aryl hydrocarbons, translocate to the nucleus, and activate transcription of particular DNA segments. AH receptors are identified by their high-affinity binding to several carcinogenic or teratogenic environmental chemicals including polycyclic aromatic hydrocarbons found in cigarette smoke and smog, heterocyclic amines found in cooked foods, and halogenated hydrocarbons including dioxins and polychlorinated biphenyls. No endogenous ligand has been identified, but an unknown natural messenger with a role in cell differentiation and development is suspected.Pseudomonas: A genus of gram-negative, aerobic, rod-shaped bacteria widely distributed in nature. Some species are pathogenic for humans, animals, and plants.Tetrachlorodibenzodioxin: A chemical by-product that results from burning or incinerating chlorinated industrial chemicals and other hydrocarbons. This compound is considered an environmental toxin, and may pose reproductive, as well as, other health risks for animals and humans.Ferredoxins: Iron-containing proteins that transfer electrons, usually at a low potential, to flavoproteins; the iron is not present as in heme. (McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)Dioxins: Chlorinated hydrocarbons containing heteroatoms that are present as contaminants of herbicides. Dioxins are carcinogenic, teratogenic, and mutagenic. They have been banned from use by the FDA.Indoles: Benzopyrroles with the nitrogen at the number one carbon adjacent to the benzyl portion, in contrast to ISOINDOLES which have the nitrogen away from the six-membered ring.Alkaloids: Organic nitrogenous bases. Many alkaloids of medical importance occur in the animal and vegetable kingdoms, and some have been synthesized. (Grant & Hackh's Chemical Dictionary, 5th ed)Catechols: A group of 1,2-benzenediols that contain the general formula R-C6H5O2.Palladium: A chemical element having an atomic weight of 106.4, atomic number of 46, and the symbol Pd. It is a white, ductile metal resembling platinum, and following it in abundance and importance of applications. It is used in dentistry in the form of gold, silver, and copper alloys.Sphingomonadaceae: A family of gram-negative, asporogenous rods or ovoid cells, aerobic or facultative anaerobic chemoorganotrophs. They are commonly isolated from SOIL, activated sludge, or marine environments.Cyclization: Changing an open-chain hydrocarbon to a closed ring. (McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)Cytochrome P-450 CYP1A1: A liver microsomal cytochrome P-450 monooxygenase capable of biotransforming xenobiotics such as polycyclic hydrocarbons and halogenated aromatic hydrocarbons into carcinogenic or mutagenic compounds. They have been found in mammals and fish. This enzyme, encoded by CYP1A1 gene, can be measured by using ethoxyresorufin as a substrate for the ethoxyresorufin O-deethylase activity.ThiophenesMolecular Structure: The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.Dermatologic Agents: Drugs used to treat or prevent skin disorders or for the routine care of skin.Bacterial Proteins: Proteins found in any species of bacterium.Benzo(a)pyrene: A potent mutagen and carcinogen. It is a public health concern because of its possible effects on industrial workers, as an environmental pollutant, an as a component of tobacco smoke.Multigene Family: A set of genes descended by duplication and variation from some ancestral gene. Such genes may be clustered together on the same chromosome or dispersed on different chromosomes. Examples of multigene families include those that encode the hemoglobins, immunoglobulins, histocompatibility antigens, actins, tubulins, keratins, collagens, heat shock proteins, salivary glue proteins, chorion proteins, cuticle proteins, yolk proteins, and phaseolins, as well as histones, ribosomal RNA, and transfer RNA genes. The latter three are examples of reiterated genes, where hundreds of identical genes are present in a tandem array. (King & Stanfield, A Dictionary of Genetics, 4th ed)Carcinogens: Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included.Crystallization: The formation of crystalline substances from solutions or melts. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Metabolic Networks and Pathways: Complex sets of enzymatic reactions connected to each other via their product and substrate metabolites.Acetic Acid: Product of the oxidation of ethanol and of the destructive distillation of wood. It is used locally, occasionally internally, as a counterirritant and also as a reagent. (Stedman, 26th ed)Oxalates: Derivatives of OXALIC ACID. Included under this heading are a broad variety of acid forms, salts, esters, and amides that are derived from the ethanedioic acid structure.Patents as Topic: Exclusive legal rights or privileges applied to inventions, plants, etc.Carboxylic Acids: Organic compounds containing the carboxy group (-COOH). This group of compounds includes amino acids and fatty acids. Carboxylic acids can be saturated, unsaturated, or aromatic.Dizocilpine Maleate: A potent noncompetitive antagonist of the NMDA receptor (RECEPTORS, N-METHYL-D-ASPARTATE) used mainly as a research tool. The drug has been considered for the wide variety of neurodegenerative conditions or disorders in which NMDA receptors may play an important role. Its use has been primarily limited to animal and tissue experiments because of its psychotropic effects.Administration, Oral: The giving of drugs, chemicals, or other substances by mouth.Potassium Iodide: An inorganic compound that is used as a source of iodine in thyrotoxic crisis and in the preparation of thyrotoxic patients for thyroidectomy. (From Dorland, 27th ed)Ethylene Dibromide: An effective soil fumigant, insecticide, and nematocide. In humans, it causes severe burning of skin and irritation of the eyes and respiratory tract. Prolonged inhalation may cause liver necrosis. It is also used in gasoline. Members of this group have caused liver and lung cancers in rodents. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), 1,2-dibromoethane may reasonably be anticipated to be a carcinogen.Benzenaminium, 4,4'-(3-oxo-1,5-pentanediyl)bis(N,N-dimethyl-N-2-propenyl-), Dibromide: Proposed cholinesterase inhibitor.Picolines: A group of compounds that are monomethyl derivatives of pyridines. (From Dorland, 28th ed)Hydrocarbons, BrominatedQuaternary Ammonium Compounds: Derivatives of ammonium compounds, NH4+ Y-, in which all four of the hydrogens bonded to nitrogen have been replaced with hydrocarbyl groups. These are distinguished from IMINES which are RN=CR2.Azirines: Unsaturated azacyclopropane compounds that are three-membered heterocycles of a nitrogen and two carbon atoms.Trifluridine: An antiviral derivative of THYMIDINE used mainly in the treatment of primary keratoconjunctivitis and recurrent epithelial keratitis due to HERPES SIMPLEX virus. (From Martindale, The Extra Pharmacopoeia, 30th ed, p557)Marketing: Activity involved in transfer of goods from producer to consumer or in the exchange of services.Research Report: Detailed account or statement or formal record of data resulting from empirical inquiry.Phospholipases A2, Secretory: A subcategory of phospholipases A2 that are secreted from cells. They are 14 kDa proteins containing multiple disulfide-bonds and access their substrate via an interfacial binding site that interacts with phospholipid membranes. In addition specific PHOSPHOLIPASE A2 RECEPTORS can bind to and internalize the enzymes.Nostoc commune: A form species of spore-producing CYANOBACTERIA, in the family Nostocaceae, order Nostocales. It is an important source of fixed NITROGEN in nutrient-depleted soils. When wet, it appears as a jelly-like mass.Nostoc: A form-genus of CYANOBACTERIA in the order Nostocales. Trichomes composed of spherical or ovoid vegetative cells along with heterocysts and akinetes. The species form symbiotic associations with a wide range of eukaryotes.6-Cyano-7-nitroquinoxaline-2,3-dione: A potent excitatory amino acid antagonist with a preference for non-NMDA iontropic receptors. It is used primarily as a research tool.Cyanobacteria: A phylum of oxygenic photosynthetic bacteria comprised of unicellular to multicellular bacteria possessing CHLOROPHYLL a and carrying out oxygenic PHOTOSYNTHESIS. Cyanobacteria are the only known organisms capable of fixing both CARBON DIOXIDE (in the presence of light) and NITROGEN. Cell morphology can include nitrogen-fixing heterocysts and/or resting cells called akinetes. Formerly called blue-green algae, cyanobacteria were traditionally treated as ALGAE.

Prior exposure to neurotrophins blocks inhibition of axonal regeneration by MAG and myelin via a cAMP-dependent mechanism. (1/1680)

MAG is a potent inhibitor of axonal regeneration. Here, inhibition by MAG, and myelin in general, is blocked if neurons are exposed to neurotrophins before encountering the inhibitor; priming cerebellar neurons with BDNF or GDNF, but not NGF, or priming DRG neurons with any of these neurotrophins blocks inhibition by MAG/myelin. Dibutyryl cAMP also overcomes inhibition by MAG/myelin, and cAMP is elevated by neurotrophins. A PKA inhibitor present during priming abrogates the block of inhibition. Finally, if neurons are exposed to MAG/myelin and neurotrophins simultaneously, but with the Gi protein inhibitor, inhibition is blocked. We suggest that priming neurons with particular neurotrophins elevates cAMP and activates PKA, which blocks subsequent inhibition of regeneration and that priming is required because MAG/myelin activates a Gi protein, which blocks increases in cAMP. This is important for encouraging axons to regrow in vivo.  (+info)

The ras oncogene-mediated sensitization of human cells to topoisomerase II inhibitor-induced apoptosis. (2/1680)

BACKGROUND: Among the inhibitors of the enzyme topoisomerase II (an important target for chemotherapeutic drugs) tested in the National Cancer Institute's In Vitro Antineoplastic Drug Screen, NSC 284682 (3'-hydroxydaunorubicin) and NSC 659687 [9-hydroxy-5,6-dimethyl-1-(N-[2(dimethylamino)ethyl]carbamoyl)-6H-pyrido -(4,3-b)carbazole] were the only compounds that were more cytotoxic to tumor cells harboring an activated ras oncogene than to tumor cells bearing wild-type ras alleles. Expression of the multidrug resistance proteins P-glycoprotein and MRP (multidrug resistance-associated protein) facilitates tumor cell resistance to topoisomerase II inhibitors. We investigated whether tumor cells with activated ras oncogenes showed enhanced sensitivity to other topoisomerase II inhibitors in the absence of the multidrug-resistant phenotype. METHODS: We studied 20 topoisomerase II inhibitors and individual cell lines with or without activated ras oncogenes and with varying degrees of multidrug resistance. RESULTS: In the absence of multidrug resistance, human tumor cell lines with activated ras oncogenes were uniformly more sensitive to most topoisomerase II inhibitors than were cell lines containing wild-type ras alleles. The compounds NSC 284682 and NSC 659687 were especially effective irrespective of the multidrug resistant phenotype. The ras oncogene-mediated sensitization to topoisomerase II inhibitors was far more prominent with the non-DNA-intercalating epipodophyllotoxins than with the DNA-intercalating inhibitors. This difference in sensitization appears to be related to a difference in apoptotic sensitivity, since the level of DNA damage generated by etoposide (an epipodophyllotoxin derivative) in immortalized human kidney epithelial cells expressing an activated ras oncogene was similar to that in the parental cells, but apoptosis was enhanced only in the former cells. CONCLUSIONS: Activated ras oncogenes appear to enhance the sensitivity of human tumor cells to topoisomerase II inhibitors by potentiating an apoptotic response. Epipodophyllotoxin-derived topoisomerase II inhibitors should be more effective than the DNA-intercalating inhibitors against tumor cells with activated ras oncogenes.  (+info)

A requirement for protein kinase C inhibition for calcium-triggered apoptosis in acute lymphoblastic leukemia cells. (3/1680)

We have evaluated the cytotoxicities of the combinations of calcium mobilizers and PKC inhibitors against human acute lymphoblastic leukemia (ALL) cells. Here we report that calcium mobilizers alone or PKC inhibitors alone do not induce apoptosis in human ALL cells. However, the combinations of calcium mobilizers with potent inhibitors of PKC cause significant apoptosis in ALL cells. Our results provide experimental evidence that PKC blocks Ca2+-triggered apoptosis in human ALL cells. Thus, PKC inhibitors can be used to enhance the antileukemic activity of chemical or biological agents that trigger an apoptotic calcium signal in ALL cells. The exquisite sensitivity of ALL cells to calcium-dependent apoptosis in the presence of PKC inhibitors could provide the basis for new treatment programs against ALL.  (+info)

Stimulation of ultraviolet-induced apoptosis of human fibroblast UVr-1 cells by tyrosine kinase inhibitors. (4/1680)

Damnacanthal is an anthraquinone compound isolated from the root of Morinda citrifolia and was reported to have a potent inhibitory activity towards tyrosine kinases such as Lck, Src, Lyn and EGF receptor. In the present study, we have examined the effects of damnacanthal on ultraviolet ray-induced apoptosis in ultraviolet-resistant human UVr-1 cells. When the cells were treated with damnacanthal prior to ultraviolet irradiation, DNA fragmentation was more pronounced as compared to the case of ultraviolet irradiation alone. The other tyrosine kinase inhibitors, herbimycin A and genistein, also caused similar effects on ultraviolet-induced apoptosis but to a lesser extent. Serine/threonine kinase inhibitors, K252a, staurosporine and GF109203X, rather suppressed the ultraviolet-induced DNA cleavage. Immunoblot analysis showed that pretreatment with damnacanthal followed by ultraviolet irradiation increased the levels of phosphorylated extracellular signal-regulated kinases and stress-activated protein kinases. However, the other tyrosine kinase inhibitors did not increase the phosphorylation of extracellular signal-regulated kinases but stimulated phosphorylation of stress-activated protein kinases. Consequently, the ultraviolet-induced concurrent increase in both phosphorylated extracellular signal-regulated kinases and stress-activated protein kinases after pretreatment with damnacanthal might be characteristically related to the stimulatory effect of damnacanthal on ultraviolet-induced apoptosis.  (+info)

Involvement of phosphodiesterase-cGMP-PKG pathway in intracellular Ca2+ oscillations in pituitary GH3 cells. (5/1680)

The present study investigates the potential role of the Ca2+-calmodulin-dependent type I phosphodiesterase (PDE)-cGMP-protein kinase G (PKG) pathway in spontaneous [Ca2+]i oscillations in GH3 cells using fura-2 single cell videoimaging. Vinpocetine (2.5-50 microM), a selective inhibitor of type I PDE, induced a concentration-dependent inhibition of spontaneous [Ca2+]i oscillations in these pituitary cells, and at the same time produced an increase of the intracellular cGMP content. The cell permeable cGMP analog N2,2'-O-dibutyryl-cGMP (dB-cGMP) (1 mM) caused a progressive reduction of the frequency and the amplitude of spontaneous [Ca2+]i oscillations when added to the medium. KT5823 (400 nM), a selective inhibitor of cGMP-dependent protein kinase (PKG), produced an increase of baseline [Ca2+]i and the disappearance of spontaneous [Ca2+]i oscillations. When KT5823 was added before vinpocetine, the PKG inhibitor counteracted the [Ca2+]i lowering effect of the cGMP catabolism inhibitor. Finally, the removal of extracellular Ca2+ or the blockade of L-type voltage-sensitive calcium channels (VSCC) by nimodipine produced a decrease of cytosolic cGMP levels. Collectively, the results of the present study suggest that spontaneous [Ca2+]i oscillations in GH3 cells may be regulated by the activity of type I PDE-cGMP-PKG pathway.  (+info)

In vitro and in vivo characterization of intrinsic sympathomimetic activity in normal and heart failure rats. (6/1680)

Clinical studies conducted with carvedilol suggest that beta-adrenoceptor antagonism is an effective therapeutic approach to the treatment of heart failure. However, many beta-adrenoceptor antagonists are weak partial agonists and possess significant intrinsic sympathomimetic activity (ISA), which may be problematic in the treatment of heart failure. In the present study, the ISAs of bucindolol, xamoterol, bisoprolol, and carvedilol were evaluated and compared in normal rats [Sprague-Dawley (SD)], in rats with confirmed heart failure [spontaneously hypertensive heart failure (SHHF)], and in isolated neonatal rat cardiomyocytes. At equieffective beta1-adrenolytic doses, the administration of xamoterol and bucindolol produced a prolonged, equieffective, and dose-related increase in heart rate in both pithed SD rats (ED50 = 5 and 40 microgram/kg, respectively) and SHHF rats (ED50 = 6 and 30 microgram/kg, respectively). The maximum effect of both compounds in SHHF rats was approximately 50% of that observed in SD rats. In contrast, carvedilol and bisoprolol had no significant effect on resting heart rate in the pithed SD or SHHF rat. The maximum increase in heart rate elicited by xamoterol and bucindolol was inhibited by treatment with propranolol, carvedilol, and betaxolol (beta1-adrenoceptor antagonist) but not by ICI 118551 (beta2-adrenoceptor antagonist) in neonatal rat. When the beta-adrenoceptor-mediated cAMP response was examined in cardiomyocytes, an identical partial agonist/antagonist response profile was observed for all compounds, demonstrating a strong correlation with the in vivo results. In contrast, GTP-sensitive ligand binding and tissue adenylate cyclase activity were not sensitive methods for detecting beta-adrenoceptor partial agonist activity in the heart. In summary, xamoterol and bucindolol, but not carvedilol and bisoprolol, exhibited direct beta1-adrenoceptor-mediated ISA in normal and heart failure rats.  (+info)

Tolerability and efficacy of carvedilol in patients with New York Heart Association class IV heart failure. (7/1680)

OBJECTIVES: The purpose of this study was to assess the tolerability and efficacy of carvedilol in patients with New York Heart Association (NYHA) functional class IV symptoms. BACKGROUND: Carvedilol, a nonselective beta-adrenergic blocking drug with alpha-adrenergic blocking and antioxidant properties, has been shown to improve left ventricular function and clinical outcome in patients with mild to moderate chronic heart failure. METHODS: We retrospectively analyzed the outcomes of 230 patients with heart failure treated with carvedilol who were stratified according to baseline functional class: 63 patients were NYHA class IV and 167 were NYHA class I, II or III. Carvedilol was commenced at 3.125 mg b.i.d. and titrated to 25 mg b.i.d. as tolerated. Patients with class IV symptoms were older (p = 0.03), had lower left ventricular fractional shortening (p < 0.001), had lower six-min walk distance (p < 0.001) and were receiving more heart failure medications at baseline compared with less symptomatic patients. RESULTS: Nonfatal adverse events while taking carvedilol occurred more frequently in class IV patients (43% vs. 24%, p < 0.0001), and more often resulted in permanent withdrawal of the drug (25% vs. 13%, p < 0.01). Thirty-seven (59%) patients who were NYHA class IV at baseline had improved by one or more functional class at 3 months, 8 (13%) were unchanged and 18 (29%) had deteriorated or died. Among the less symptomatic group, 62 (37%) patients had improved their NYHA status at 3 months, 73 (44%) were unchanged and 32 (19%) had deteriorated or died. The differences in symptomatic outcome at three months between the two groups were statistically significant (p = 0.001, chi-square analysis). Both groups demonstrated similar significant improvements in left ventricular dimensions and systolic function. CONCLUSIONS: Patients with chronic NYHA class IV heart failure are more likely to develop adverse events during initiation and dose titration when compared with less symptomatic patients but are more likely to show symptomatic improvement in the long term. We conclude that carvedilol is a useful adjunctive therapy for patients with NYHA class IV heart failure; however, they require close observation during initiation and titration of the drug.  (+info)

Membrane fusion promoters and inhibitors have contrasting effects on lipid bilayer structure and undulations. (8/1680)

It has been established that the fusion of both biological membranes and phospholipid bilayers can be modulated by altering their lipid composition (Chernomordik et al., 1995 .J. Membr. Biol. 146:3). In particular, when added exogenously between apposing membranes, monomyristoylphosphatidylcholine (MMPC) inhibits membrane fusion, whereas glycerol monoleate (GMO), oleic acid (OA), and arachidonic acid (AA) promote fusion. This present study uses x-ray diffraction to investigate the effects of MMPC, GMO, OA, and AA on the bending and stability of lipid bilayers when bilayers are forced together with applied osmotic pressure. The addition of 10 and 30 mol% MMPC to egg phosphatidylcholine (EPC) bilayers maintains the bilayer structure, even when the interbilayer fluid spacing is reduced to approximately 3 A, and increases the repulsive pressure between bilayers so that the fluid spacing in excess water increases by 5 and 15 A, respectively. Thus MMPC increases the undulation pressure, implying that the addition of MMPC promotes out-of-plane bending and decreases the adhesion energy between bilayers. In contrast, the addition of GMO has minor effects on the undulation pressure; 10 and 50 mol% GMO increase the fluid spacing of EPC in excess water by 0 and 2 A, respectively. However, x-ray diffraction indicates that, at small interbilayer separations, GMO, OA, or AA converts the bilayer to a structure containing hexagonally packed scattering units approximately 50 A in diameter. Thus GMO, OA, or AA destabilizes bilayer structure as apposing bilayers are brought into contact, which could contribute to their role in promoting membrane fusion.  (+info)

*Carbazole

In the third step, this compound is oxidized by red lead to carbazole itself. Another classic is the Bucherer carbazole ... Carbazole is a constituent of tobacco smoke. A classic laboratory organic synthesis for carbazole is the Borsche-Drechsel ... Carbazole is an aromatic heterocyclic organic compound. It has a tricyclic structure, consisting of two six-membered benzene ... A second method for the synthesis of carbazole is the Graebe-Ullmann reaction. In the first step, an N-phenyl-1,2- ...

*Bucherer carbazole synthesis

The Bucherer carbazole synthesis is a chemical reaction used to synthesize carbazoles from naphthols and aryl hydrazines using ...

*Carbazole 1,9a-dioxygenase

... (EC 1.14.12.22, CARDO) is an enzyme with systematic name 9H-carbazole,NAD(P)H:oxygen oxidoreductase ... Carbazole 1,9a-dioxygenase catalyses the first reaction in the pathway of carbazole degradation. Nam, J.W.; Nojiri, H.; Noguchi ... Carbazole 1,9a-dioxygenase at the US National Library of Medicine Medical Subject Headings (MeSH) Molecular and Cellular ... "The genes coding for the conversion of carbazole to catechol are flanked by IS6100 elements in Sphingomonas sp. strain XLDN2-5 ...

*N-Vinylcarbazole

Carbazole Lide, David R. (2008). CRC Handbook of Chemistry and Physics, 89th Edition. CRC Press. pp. 3-518. ISBN 978-0-8493- ... One possible synthesis, patented by Nippon Shokubai, is based on the reaction of carbazole with ethylene carbonate at 300 °C ( ... This reaction produces N-(2-Hydroxyethyl) carbazole, which in turn generates vinylcarbazole through water eliminiation. ...

*Anthracene

Common impurities are phenanthrene and carbazole. A classic laboratory method for the preparation of anthracene is by ...

*Anthraniloyl-CoA monooxygenase

This enzyme participates in carbazole degradation. It employs one cofactor, FAD. Buder R, Fuchs G (1989). "2-Aminobenzoyl-CoA ...

*Pseudomonas

P. resinovorans, which can degrade carbazole. P. veronii, which has been shown to degrade a variety of simple aromatic organic ... 2002). "Organization and transcriptional characterization of catechol degradation genes involved in carbazole degradation by ...

*Borsche-Drechsel cyclization

... is the central step in Borsche-Drechsel carbazole synthesis, where in the first step ... and in the final step the resulting tetrahydrocarbazole is oxidized to carbazole itself. E. Drechsel (1888). "Ueber Elektrolyse ...

*Murraya

Some species also contain the carbazole girinimbine. M. koenigii has yielded a vast array of compounds, including carbazoles ...

*Stilbene photocyclization

9) Cyclization of arylvinyl- or diarylamines provides indolines and carbazoles, respectively. In one interesting example, the ...

*Indolocarbazole

... carbazoles are the Indolo(2,3-a)pyrrole(3,4-c)carbazoles. These can be divided into two major classes - halogenated ( ... The most frequently isolated indolocarbazoles are Indolo(2,3-a)carbazoles; the most common subgroup of the Indolo(2,3-a) ... carbazoles and preparation of various functionalized derivatives". J. Org. Chem. 72: 7207-7213. doi:10.1021/jo0711337. Faul M. ... carbazole by palladium(0) catalyzed polyannulation". Tetrahedron Lett. 36: 7841-7844. doi:10.1016/0040-4039(95)01644-w. CS1 ...

*Jeffrey S. Moore

"Engineering Solid-State Morphologies in Carbazole-Ethynylene Macrocycles". Journal of the American Chemical Society. 133 (35): ...

*Nocardioides aromaticivorans

... has the ability to degrade dibenzofuran and carbazole. LPSN bacterio.net Straininfo of ...

*Pigment violet 23

228-767-9, CAS RN 6358-30-1) which differ in terms of the carbazole ring fusion. Pigment violet 23 is prepared by condensation ... It is member of the dioxazine family of heterocyclic compounds, but derived from carbazoles. It is prepared by condensation of ...

*O-pyrocatechuate decarboxylase

This enzyme participates in benzoate degradation via hydroxylation and carbazole degradation. Rao PV, Moore K, Towers GH (1967 ...

*Staurosporine

Halogenated indolo(2,3-a)pyrrole(3,4-c)carbazoles have a fully oxidized C-7 carbon with only one indole nitrogen containing a β ... Of these, Staurosporine falls within the most common subgroup, called Indolo(2,3-a)pyrrole(3,4-c)carbazoles. These fall into ... It belongs to the most frequently isolated group of indolocarbazoles: Indolo(2,3-a)carbazoles. ... bond, while non-halogenated indolo(2,3-a)pyrrole(3,4-c)carbazoles have both indole nitrogens glycosylated, and a fully reduced ...

*Bicyclohexyl

Carbazole can be denitrogenated by hydrogen to yield bicyclohexyl as the main product. When cyclohexane is exposed to radiation ...

*Hemiaminal

doi:10.1021/ed077p1644 Carbazol-9-yl-methanol Milata Viktora, Kada Rudolfa, Lokaj J¨¢nb Molbank 2004, M354 open access ... Illustrative is the reaction of the weakly basic secondary amine carbazole with formaldehyde. As is typical with a secondary ... amine derivative, this carbinol converts readily to the methylene-linked bis(carbazole). Those generated from primary amines ...

*Bucherer reaction

The reaction is summarized as follows: The Bucherer carbazole synthesis is a related reaction. H. Bucherer (1904). "Über die ...

*Pseudomonas resinovorans

It is able to degrade carbazole, and as such, may be used in bioremediation. Based on 16S rRNA analysis, P. resinovorans has ... "Organization and transcriptional characterization of catechol degradation genes involved in carbazole degradation by ...

*Oxindole

Indoline Indole Indene Benzofuran Isoindoline Carboline Isatin Methylindole Carbazole Pyrrole Skatole Benzene Riggio, Oliviero ...

*Indole

... carbazoles from 2-(Benzotriazol-1-ylmethyl)indole". J. Org. Chem. 60 (11): 3401-3404. doi:10.1021/jo00116a026. Lynch, S. M.; ...

*Anthranilate 3-monooxygenase (deaminating)

... carbazole degradation, and nitrogen metabolism. Powlowski JB, Dagley S, Massey V, Ballou DP (1987). "Properties of anthranilate ...

*Anthranilate 1,2-dioxygenase (deaminating, decarboxylating)

This enzyme participates in 3 metabolic pathways: benzoate degradation via hydroxylation, carbazole degradation, and nitrogen ...

*2-hydroxy-6-oxo-6-(2-aminophenyl)hexa-2,4-dienoate hydrolase

4-dienoate This enzyme catalyses the third step in the aerobic degradation pathway of carbazole. Nojiri, H.; Taira, H.; Iwata, ... 4-dienoic acid hydrolase involved in microbial degradation of carbazole". Protein Expr. Purif. 28 (1): 182-189. doi:10.1016/ ... "Purification and characterization of meta-cleavage compound hydrolase from a carbazole degrader Pseudomonas resinovorans strain ...
Article Investigation of carbazole degradation by the sono-Fenton process. The present report aimed to describe the roles of ultrasonic power and reaction time in the Fenton reagent-based degradation of carbazole in wastewater, and to analyze the eff...
6-Formylindolo[3,2-b]carbazole (FICZ) is a potent aryl hydrocarbon receptor (AHR) agonist that is efficiently metabolized by AHR-regulated cytochrome P4501 enzymes. FICZ is a proposed physiological AHR ligand that induces its own degradation as part of a regulatory negative feedback loop. In vitro studies in cells show that CYP1 inhibition in the presence of FICZ results in enhanced AHR activation, suggesting that FICZ accumulates in the cell when its metabolism is blocked. We used zebrafish (Danio rerio) embryos to investigate the in vivo effects of FICZ when CYP1A is knocked down or inhibited. Embryos were injected with morpholino antisense oligonucleotides targeting CYP1A (CYP1A-MO), Ahr2, or a combination of both. FICZ exposure of non-injected embryos or embryos injected with control morpholino had little effect. In CYP1A-MO-injected embryos, however, FICZ dramatically increased mortality, incidence and severity of pericardial edema and circulation failure, reduced hatching frequency, ...
TY - JOUR. T1 - Carvedilol increases ciclosporin bioavailability by inhibiting P-glycoprotein-mediated transport. AU - Amioka, Katsuo. AU - Kuzuya, Takafumi. AU - Kushihara, Hideyuki. AU - Ejiri, Masayuki. AU - Nitta, Atsumi. AU - Nabeshima, Toshitaka. PY - 2007/10/1. Y1 - 2007/10/1. N2 - Carvedilol is often used to treat hypertension and for prophylaxis in vascular sclerosis in renal transplant recipients, who require concomitant treatment with ciclosporin. However, there are few reports regarding the pharmacokinetic interactions between carvedilol and ciclosporin. We have investigated the potential effects of carvedilol on the pharmacokinetics of ciclosporin, and examined the inhibitory effects of carvedilol on P-glycoprotein-mediated transcellular transport using Caco2 cells. Ciclosporin alone or with carvedilol was orally or intravenously administered to rats. The oral administration of carvedilol (10 mg kg-1) with Ciclosporin (10 mg kg-1) increased the whole blood concentration of ...
7H-Dibenzo(c,g)carbazole is carcinogenic in the mouse, rat, hamster and possibly in the dog. It has both a local and systemic carcinogenic effect. Following oral administration in the mouse, forestomach tumours and hepatomas occurred; intratracheal administration to hamsters produced tumours of the respiratory tract. In comparison with benzo(a)pyrene, 7H-dibenzo(c,g)carbazole appears to be a stronger respiratory tract carcinogen for the hamster. ...
Histamine can u symptoms of sneezing, itching, spacy eyes, and runny info on carvedilol. Acetaminophen and diphenhydramine is a few medicine used to end headache. This combination product contains 2 years, acetaminophen and an antihistamine. Acetaminophen studies to reduce info on carvedilol andor quickly to moderate pain (such as other, backache, achespains due to person strain, cold, or flu). The antihistamine in this medication may cause drowsiness, and therefore it can also be. Tho interaction with Tylenol PM is not a year with your blood clotting drugs, you also take taking herbs. More:. ...
The purpose of the study is to measure decline in episodic memory in participants with early AD taking carvedilol compared to placebo treatment as evidenced by the Hopkins Verbal Learning Test (HVLT). cerebrospinal fluid levels of Aβ oligomers in early AD, will be measured in participants receiving carvedilol treatment when compared to placebo treatment. Adverse effects will be monitored in participants receiving carvedilol when compared to placebo.. To assess adverse events, routine chemistry and hematology studies, vital signs, and electrocardiographic parameters before and after 6 months randomized placebo-controlled double-blind treatment with carvedilol at a target dose of 25 mg daily, comparing 25 early AD participants taking carvedilol vs. 25 early AD participants taking placebo. ...
... is an indolocarbazole isolated from Lechevalieria aerocolonigenes. Rebeccamycin displays selective antitumor activity against several cell lines. Analogues of rebeccamycin have been tested in clinical trials for cancer therapy ...
6-cyano-5-methoxy-12-methylindolo(2,3-a)carbazole: structure given in first source; indolocarbazole from blue-green algae Nostoc sphaericum; active against HSV II
207-88-5 - SRFZWNXMRFIYRW-UHFFFAOYSA-N - 13H-(Benzo(g)pyrido(2,3-a))carbazole - Similar structures search, synonyms, formulas, resource links, and other chemical information.
OBJECTIVES. Carprofen is a non-steroidal anti-inflammatory drug. According to its anti-inflammatory effects and low renal toxicity, carprofen perioperative use is relatively safe.. Methods for assessment pain in veterinary are adaptations of scales used in human pain measurement. The most currently used are the simple descriptive scale, numerical rating scale and visual analogue scale. Pain score is based on subjective behavioral observation.. Multiparametrics scales, using different variables, try to minimize subjectivity of observer. The objective of this study is to determinate effectiveness of the carprofen in the control of postoperative immediate pain in dogs using a multiparametric scale.. MATERIALS. Dogs undergoing surgery were allocated by random draw into 3 groups: group A: 5 dogs given carprofen (4 mg/kg) prior surgery and saline (0.9% NaCl) solution after surgery, group B: 5 dogs given saline solution prior surgery and carprofen after surgery, group C: 5 dogs given saline solution ...
OBJECTIVES. Carprofen is a non-steroidal anti-inflammatory drug. According to its anti-inflammatory effects and low renal toxicity, carprofen perioperative use is relatively safe.. Methods for assessment pain in veterinary are adaptations of scales used in human pain measurement. The most currently used are the simple descriptive scale, numerical rating scale and visual analogue scale. Pain score is based on subjective behavioral observation.. Multiparametrics scales, using different variables, try to minimize subjectivity of observer. The objective of this study is to determinate effectiveness of the carprofen in the control of postoperative immediate pain in dogs using a multiparametric scale.. MATERIALS. Dogs undergoing surgery were allocated by random draw into 3 groups: group A: 5 dogs given carprofen (4 mg/kg) prior surgery and saline (0.9% NaCl) solution after surgery, group B: 5 dogs given saline solution prior surgery and carprofen after surgery, group C: 5 dogs given saline solution ...
Alfa Chemistry is the worlds leading provider for special chemicals. We offer qualified products for 116989-96-9(6H-Indolo[2,3-b]quinoxaline-6-aceticacid, 2-(1-phenylethylidene)hydrazide),please inquire us for 116989-96-9(6H-Indolo[2,3-b]quinoxaline-6-aceticacid, 2-(1-phenylethylidene)hydrazide).
Coreg Cost carvedilol 12.5 mg tab teva carvedilol vr carvedilol fosfato coreg 100 mg carvedilol cost without insurance generic coreg cr 20 mg buy corega denture adhesive.Cr 20 mg generic name zyprexa price comparison coreg 7295 sales.Buy cr have here in usa 6.25 mg carvedilol lp 40 carvedilol 3.125mg price fosfato 40 mg precio.Find patient medical information for Coreg CR oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings.. Coreg CR is a brand name of carvedilol, approved by the FDA in the following formulation(s).Cheap Coreg Online, Can Carvedilol Have The Opposite Effect Carvedilol Cost when will coreg cr become generic coreg cr 40 coupon carvedilol 5 mg cost.Revenue - Coreg CR data for GlaxoSmithKline: industry ranking, historical trend, and competitor comparison.Learn about the prescription medication Coreg (Carvedilol), drug uses, dosage, side effects, drug interactions, warnings, reviews and patient labeling.Generic problems ...
carvedilol order online carvedilol no prescription carvedilol online pharmacy buy carvedilol tablet online You need to get used to this medication, but it is really very effective. It has in fact save
Product Name: 5,7-Dihydro-7,7-dimethyl-indenocarbazoleFormula: C21H17NWeight: 283.36638SMILES: C1C=C2C(=CC=1)C3=C(N2)C=C4C(C)(C)C5C(=CC=CC=5)C4=C3CAS NO:
We examined in vivo FLT3 inhibition in AML patients treated with chemotherapy followed by the FLT3 inhibitor lestaurtinib, comparing newly-diagnosed AML patients with relapsed patients. Because we noted that in vivo FLT3 inhibition by lestaurtinib was less effective in the relapsed patients compared with the newly-diagnosed patients, we investigated whether plasma FLT3 ligand (FL) levels could influence the efficacy of FLT3 inhibition in these patients. Following intensive chemotherapy, FL levels rose to a mean of 488 pg/mL on day 15 of induction therapy for newly-diagnosed patients, while they rose to a mean of 1148 pg/mL in the relapsed patients. FL levels rose even higher with successive courses of chemotherapy, to a mean of 3251 pg/mL after the fourth course. In vitro, exogenous FL at concentrations similar to those observed in patients mitigated FLT3 inhibition and cytotoxicity for each of 5 different FLT3 inhibitors (lestaurtinib, midostaurin, sorafenib, KW-2449, and AC220). The dramatic ...
The present invention relates to carvedilol phosphate salts, which include novel crystalline forms of carvedilol dihydrogen phosphate (i.e., dihydrogen phosphate salt of 1-(carbazol-4-yloxy-3-[[2-(o-methoxyphenoxy) ethyl]amino]-2-propanol) and/or carvedilol hydrogen phosphate, etc.), and/or solvates thereof, compositions containing the aforementioned salts and/or solvates, and methods of using the aforementioned salts and/or solvates to treat hypertension, congestive heart failure and angina, etc.
The present invention relates to carvedilol phosphate salts, which include novel crystalline forms of carvedilol dihydrogen phosphate (i.e., dihydrogen phosphate salt of 1-(carbazol-4-yloxy-3-[[2-(o-methoxyphenoxy) ethyl]amino]-2-propanol) and/or carvedilol hydrogen phosphate, etc.), and/or solvates thereof, compositions containing the aforementioned salts and/or solvates, and methods of using the aforementioned salts and/or solvates to treat hypertension, congestive heart failure and angina, etc.
Results Screening At SJCRH, screening of about 3,800 FDA accredited medication together with other bio actives recognized 24 compounds with EC50 values 1 uM. Of those, 19 had acknowledged pharmacokinetic and or security profiles that had been deemed unsuitable for development as an oral anti malarial drug. In the other compounds, two are available only for topical external use, pravastatin cant be used in pregnancy, and sulphamerazine is actually a sulphonamide a class of molecule that has already yielded anti malarial medication, though P. falciparum has formulated resistance to your compounds which are utilised clinically. Lestaurtinib is really a protein kinase inhibitor in development by Cephalon Inc for acute myelogenous leukaemia and myeloprolifera tive problems. Clinical facts on this compound was limited on the time from the study and protein kinase inhibi tors are suggested as an essential target in malaria. So, only lestaurtinib was progressed to the P. falciparum HuSCID mouse model. ...
Carvedilol is a medicine available in a number of countries worldwide. A list of US medications equivalent to Carvedilol is available on the Drugs.com website.
Could Carvedilol cause Poisoning? We studied 42,470 Carvedilol users who have side effects from FDA and eHealthme. Among them, 43 have Poisoning. See what we found.
Order Coreg online - Can I Order Carvedilol Without Prescription Genuine Coreg To Buy. Buy Coreg Winston-Salem Order Cheap Coreg 6.25mg Tags: carvedilol, coreg.
VetDepot offers Vetprofen (carprofen) 100 mg, 240 Caplets at the most competitive prices. Get the best deals on all your pet meds at VetDepot. Vetprofen (carprofen) is an NSAID pain medication indicated for the relief of pain and inflammation associated with osteoarthritis.
... for only $74.96. Find out more about Quellin Carprofen Soft Chew - Generic to Rimadyl 100 mg chewables 60 ct by BAYER and check out opinions from other buyers. Discounts, deals, special offers for Pet Supply on ShopMania.
The Dropship Medicines is a high quality exporter and supplier of Pharmcy Medicines.We are provided generic pharmacy wholesale, Medicine Dropshipper.Generic Coreg (Carvedilol)Coreg is is a beta blocker applied in treatment of heart failure and hypertension (high blood pressure).
... Coreg is used to treat high blood pressure, heart failure and after a heart attack to improve the chance of survival.
Your doctor may need to lower your dosage or temporarily stop carvedilol if this. and beautify hair dates back to the Heian Period in
Putney Carprofen Caplets are indicated for the relief of pain and inflammation associated with osteoarthritis and for the control of postoperative pain associated with soft tissue and orthopedic surgeries in dogs.
Putney Carprofen Caplets are indicated for the relief of pain and inflammation associated with osteoarthritis and for the control of postoperative pain associated with soft tissue and orthopedic surgeries in dogs.
Learn about Carprofen Caplets for animal usage including: active ingredients, directions for use, precautions, and storage information.
Application of Japp-Klingemann Reaction in the synthesis of Carbazoles and Azacarbazole derivatives: Synthesis of 1,8-disubstituted-2,3-dihydro-1H-pyrido[3,2-b]indol-4-(5H)-ones from aryl amines ...
ATLANTA - An investigational oral targeted agent called lestaurtinib (CEP-701), a FLT3 kinase inhibitor, can enhance the likelihood of complete remissions, compared with chemotherapy alone, for poor-p
HAMERTON, I, PIELICHOWSKI, J and PIELICHOWSKI, K (1994) A STUDY OF THE THERMAL-DEGRADATION OF POLY(VINYL CHLORIDE) IN THE PRESENCE OF CARBAZOLE AND POTASSIUM CARBAZOLE USING TGA/FTIR ...
The findings of the present study indicate that, in addition to prolonging survival, carvedilol ameliorates the morbidity of patients with severe chronic heart failure when assessed by both patients and physicians. During long-term treatment, carvedilol-treated patients were more likely to feel better and less likely to feel worse than patients in the placebo group. This symptomatic benefit was apparent even though all patients had had symptoms at the start of the study that had been refractory to conventional therapy for heart failure. At the same time, carvedilol markedly reduced the risk of clinical deterioration, as reflected by physician reports of the occurrence of hospitalization or a serious adverse event. Carvedilol reduced the combined risk of death or hospitalization for heart failure by 31%, of death or cardiovascular hospitalization by 27%, and of death or hospitalization for any reason by 24%. Fewer patients in the carvedilol group than in the placebo group were hospitalized for ...
Structure, properties, spectra, suppliers and links for: 12-(2-Cyanoethyl)-6,7,12,13-tetrahydro-13-methyl-5-oxo-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole.
TY - JOUR. T1 - Cyclizative Condensations. IV. 3,3′ Alkylidenebisindoles from Methyl Ketones and Their Conversion to Indolo[2,3-bjcarbazoles. AU - Noland, Wayland E. AU - Venkiteswaran, M. R.. PY - 1961/11. Y1 - 1961/11. N2 - Condensation of acetone with 5-methylindole and 5-benzyloxyindole in refluxing acetic acid gave the bisindoles Ie and If. Similarly, condensation of acetophenone with indole, 1-methylindole, and 2-methylindole gave the corresponding bisindoles Ih, Ii, and IXc. Condensation of acetone with indole or with the corresponding bisindole (Id) in refluxing maleic acid solution gave the indolo[2,3-b]carbazole IIf, while the corresponding condensation of acetone with the bisindole (Ie) from 5-methylindole gave the indolo [2,3-b] carbazole IIg. Condensation of acetone with 1-methylindole or with the corresponding bisindole (Ig) in ethanolic hydrochloric acid gave the indolo [2,3-b] carbazole IIh. Condensation of indole with acetophenone in ethanolic hydrochloric acid gave the ...
A process for the preparation of carvedilol of formula (I) (I) either in enantiomeric substantially pure form, or as an enantiomeric mixture, optionally as a pharmaceutically acceptable salt thereof, which process comprises reacting 2,3-eopxypropoxy carbazole of formula (II) (II) or the R or S enantiomer thereof, with N-[2-(2-methoxy-phenoxy)ethyl]-benzylamine of formula (V) (V) to yield benzyl carvedilol of formula (VI) (VI) which is debenzylated by catalytic hydrogenation to yield carvedilol of formula (I), either in enantiomeric substantially pure form, or as an enantiomeric mixture, and if desired reacting the thus formed carvedilol of formula (I) with an inorganic or organic acid to yield a pharmaceutically acceptable salt thereof, and/or, if desired, separating the enantiomers. The above process is characterised in that reaction of said 2,3-epoxypropoxy carbazole of formula (II) with said N-[2-(2-methoxy-phenoxy)ethyl]-benzylamine of formula (V) is carried out in water as the reaction ...
Analysis of compounds present in complex matrices is always a challenge, which can be partly overcome by applying various sample preparation techniques prior to detection. Ideally, the extraction techniques should be as selective as possible, to minimize the concentration of interfering substances. In addition, results can be improved by efficient chromatographic separation of the sample components. The elimination of interfering substances is especially important when utilizing mass spectrometry (MS) as a detection technique since they influence the ionization yields. It is also important to optimize ionization methods in order to minimize detection limits.. In the work this thesis is based upon, selective solid phase extraction (SPE) materials, a restricted access material (RAM) and graphitized carbon black (GCB) were employed for clean up and/or pre-concentration of analytes in plasma, urine and agricultural drainage water prior to liquid chromatography/mass spectrometry (LC/MS). Two SPE ...
A total of 6,975 patients with mild to severe heart failure were evaluated in placebo-controlled studies of carvedilol. Mild-to-Moderate Heart Failure: Carvedilol was studied in 5 multicenter, placebo-controlled studies, and in 1 active-controlled study (COMET study) involving patients with mild-to-moderate heart failure. Four US multicenter, double-blind, placebo-controlled studies enrolled 1,094 patients (696 randomized to carvedilol) with NYHA class II-III heart failure and ejection fraction ≤ 0.35. The vast majority were on digitalis, diuretics, and an ACE inhibitor at study entry. Patients were assigned to the studies based upon exercise ability. An Australia-New Zealand double-blind, placebo-controlled study enrolled 415 patients (half randomized to carvedilol) with less severe heart failure. All protocols excluded patients expected to undergo cardiac transplantation during the 7.5 to 15 months of double-blind follow-up. All randomized patients had tolerated a 2-week course on carvedilol ...
BACKGROUND Beta-blockers improve left ventricular (LV) systolic function and prognosis in patients with chronic heart failure. Both carvedilol and nebivolol have hemodynamic and clinical benefits in chronic heart failure (CHF), but it is unknown whether their pleiotropic properties may play a role in different subgroups of patients with CHF.. OBJECTIVE: To compare the effects of nebivolol and carvedilol on LV function and clinical outcome in patients with chronic heart failure and reduced LV systolic function.. METHODS: 160 hypertensive CHF patients, LV ejection fraction (EF) 40% and in New York Heart Association (NYHA) functional class II or III were randomly assigned to receive carvedilol or nebivolol therapy for 24 months. At baseline and after 24 months of treatment, all patients underwent clinical evaluation: echocardiogram and 6-minute walking test. ...
Postfunctionalization of Alkyne-Linked Conjugated Carbazole Polymer by Thermal Addition Reaction of Tetracyanoethylene. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
Rats undergoing laparotomy received either carprofen (5 mg/kg) or ketoprofen (5 mg/kg) administered orally in flavoured gelatin, or by subcutaneous injection. A control group that received no analgesic showed a significant (3 per cent) fall in bodyweight (P=0.009) after laparotomy. This decrease was greater than that seen in the groups receiving carprofen (P=006) or ketoprofen (Pd=0012) administered subcutaneously, which continued to gain weight following surgery. All animals showed a significant fall in food consumption but this decrease was greater in the jelly alone group (47 per cent) than in the group receiving carprofen (17 per cent) (P=0.015) administered subcutaneously. A significant fall in water consumption occurred in the control group (40 per cent) and in animals that received oral carprofen (13 per cent) or ketoprofen (22 per cent). No significant decrease was seen in groups receiving either carprofen or ketoprofen administered subcutaneously (P,0.1). This study shows that a ...
Carvedilol - Get up-to-date information on Carvedilol side effects, uses, dosage, overdose, pregnancy, alcohol and more. Learn more about Carvedilol
Measures of interest included hospitalization frequency, numbers of hospital days in special-care units (e.g., ICU/CCU) and overall, utilization of selected cardiovascular procedures, and costs of cardiovascular-related in-patient care. A cost was assigned to each cardiovascular hospitalization using cost-prediction models that were estimated using a large database containing admission-level information from 153 U.S. short-term, acute-care hospitals (HCIA, Inc.) (22). Data available for each hospital discharge included all International Classification of Diseases, Ninth Revision (ICD-9-CM) diagnoses and procedure codes, time spent in various units (e.g., ICU/CCU), services used, and total hospitalization cost. Four distinct models were developed, corresponding to the four cardiovascular primary admission causes designated on the study case-report form.. To select a master sample of hospital admissions for model estimation, all hospital stays in the HCIA database with a listed principalor ...
A process for the preparation of 6-chloro-.alpha.-methylcarbazole-2-acetic acid from 6-chloro-.alpha.-hydroxy-.alpha.-methylcarbazole-2-acetic acid and/or 6-chloro-.alpha.-methylene-2-carboxylic acid, is described. The preparation of intermediates, such as, 6-chloro-.alpha.-hydroxy-.alpha.-methylcarbazole-2-acetic acid and lower alkyl carbazole-2-oxalate, inter alia, is also described.
Pregnancy Category C. Studies performed in pregnant rats and rabbits given carvedilol revealed increased post-implantation loss in rats at doses of 300 mg per kg per day (50 times the maximum recommended human dose [MRHD] as mg per m2) and in rabbits at doses of 75 mg per kg per day (25 times the MRHD as mg per m2). In the rats, there was also a decrease in fetal body weight at the maternally toxic dose of 300 mg per kg per day (50 times the MRHD as mg per m2), which was accompanied by an elevation in the frequency of fetuses with delayed skeletal development (missing or stunted 13th rib). In rats the no-observed-effect level for developmental toxicity was 60 mg per kg per day (10 times the MRHD as mg per m2); in rabbits it was 15 mg per kg per day (5 times the MRHD as mg per m2). There are no adequate and well-controlled studies in pregnant women. Carvedilol should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. ...
Influence of carvedilol on hospitalizations in heart failure: indicence, resource utilization and costs. U.S. Carvedilol Heart Failure Study Group ...
Manzamine A is a vacuolar ATPase uncoupler and GSK-3 inhibitor found in marine sponges. It inhibits autophagy and tumor growth in cancer models, suppresses foam cell formation in macrophages, prevents growth of gram positive and gram negative bacteria, and decreases tau hyperphosphorylation.
This invention relates to carvedilol methanesulfonate, compositions containing this compound and methods of using carvedilol methanesulfonate to treat hypertension, congestive heart failure and angina.
Buy Novox 100 mg, 60 Chewable Tablets (Carprofen) at VetDepot. Get the best prices on discount Novox 100 mg, 60 Chewable Tablets (Carprofen).
The IUPHAR/BPS Guide to Pharmacology. carprofen ligand page. Quantitative data and detailed annnotation of the targets of licensed and experimental drugs.
Donor-Acceptor (D-π-A) type carbazole-porphyrin dyads and triads were synthesized in good yields through palladium catalyzed coupling reactions. The length of the spacer between the D (carbazole) and A (porphyrin) was ...
This study shows a molecular design strategy for controlling the dihedral angle of two carbazole donors linked to a 2,4-diphenyl-1,3,5-triazine acceptor by a ...
ratio-Carvedilol: Carvedilol belongs to the class of medications called beta-blockers. Carvedilol is used to treat congestive heart failure (CHF), including severe heart failure. It is often taken with a diuretic (water pill) and an angiotensin converting enzyme (ACE) inhibitor.
Apo-Carvedilol: Carvedilol belongs to the class of medications called beta-blockers. Carvedilol is used to treat congestive heart failure (CHF), including severe heart failure. It is often taken with a diuretic (water pill) and an angiotensin converting enzyme (ACE) inhibitor.
Buy KT 5823 - an affordable, high quality PKG Inhibitor from Hello Bio, a trusted supplier for life science researchers worldwide
And we were able to significantly reduce net financial debt to EUR 0. Carvedilol counter cod next day buy carvedilol internet. Generic Viagra impotence
Indikasjoner:Behandling av essensiell hypertensjon og kronisk stabil angina pectoris. Tilleggsbehandling ved moderat til alvorlig stabil hjertesvikt i
Discount Pet Prescriptions from Australian Pharmacists. Leading Pet Pharmacy selling discount pet medicines like Vetmedin, Fortekor and Caninsulin.
Two materials containing carbazole moieties and exhibiting a high band gap energy, 3,8-di(9H-carbazol-9-yl)-6-phenylphenanthridine (DCzP) and 3,6-di(naphthalene-2-yl)-9-phenyl-9H-carbazole (DNaC), were synthesized via C{single bond}N coupling and Suzuki coupling reactions, respectively. The compound DCzP exhibited blue emission with the CIE coordinates of x = 0.165 and y = 0.136 from the OLED device, ITO(indium-tin oxide)/NPB(N,N′-bis(naphthalene-1-yl)-N,N′-bis(phenyl)benzidine)/DCzP/LiF/Al. The doped device, ITO/2-TNATA(4,4′,4″-Tris(2-naphtylphenyl-phenylamino) triphenyl amine)/NPB/DCzP + Ir(ppy)3/BCP(2,9-Dimethyl-4,7-diphenyl-1,10-phenanthroline)/Alq3(tris(8-hydroxyquinoline)aluminum/LiF/Al, showed bright yellowish-green emission with a maximum luminance of 23,000 cd/m2 when the synthesized DCzP was applied as a host material for the phosphorescent green dopant. From the double layer device, ITO/DNaC/Alq3/LiF/Al, in which DNaC was used as the hole transporting material, the ...
Chemical Equation Presented) Cyclization reactions involving cyanoacetylated bisindoles have been studied, providing access to various novel cyclohepta[2,1-b:3,4-b′]diindole derivatives as well as some related fused pentacyclic systems. Treatment of 3-cyanoacetyl-2,3′-diindolylmethane with methanesulfonic acid gave 6-(cyanomethyl)indolo[3,2-b]carbazole in a good yield.. ...
In humans, orally administered carvedilol is absorbed rapidly and then undergoes extensive hepatic metabolism that involves oxidation and conjugation. It has been reported that oxidative metabolism of carvedilol is catalyzed generally by CYP2D6, which also metabolizes a number of other β-blockers such as metoprolol, propranolol, and bufuralol (Madani et al., 1999; Johnson et al., 2000; Narimatsu et al., 2002). However, with the exception of propranolol, there are no reports on the human UGT isoforms involved in the glucuronidation of β-blockers (Coffman et al., 1998; Li et al., 2001). Since glucuronidation is the predominant metabolic pathway of carvedilol, identification of the human liver UGT isoforms participating in this process is important for safe usage of this drug.. Carvedilol has three potential conjugation sites, the aliphatic secondary hydroxyl group at the chiral center, the aliphatic secondary amino group, and the carbazolyl amine moiety, and therefore, it can be glucuronidated ...
Baseline characteristics were well matched between the treatment groups. Mean body mass index at baseline was 34, and hemoglobin A1c (HbA1c) was 7.2%. Multiple antidiabetic medications were used in 55% of patients, and 8% of patients were insulin-dependent. In addition to 99% of patients taking angiotensin-converting enzyme (ACE) inhibitors or angiotensin-receptor blockers (ARBs) at baseline, 45% were taking a statin. Treatment duration was slightly but significantly longer in the carvedilol group (155 days vs. 147 days for metoprolol, p=0.01 ...
This study was designed to investigate the effects of ticlopidine on the pharmacokinetics of carvedilol after oral or intravenous administration of carvedilol in rats. Carvedilol was administered orally (3 mg/kg) or intravenously (1 mg/kg) without or with oral administration of ticlopidine (4, 12 mg...
The stress-related catecholamine hormones and the α- and β-adrenergic receptors (α- and β-AR) may affect carcinogenesis. The β-AR GRK/β-arrestin biased agonist carvedilol can induce β-AR-mediated transactivation of the epidermal growth factor receptor (EGFR). The initial purpose of this study was to determine whether carvedilol, through activation of EGFR, can promote cancer. Carvedilol failed to promote anchorage-independent growth of JB6 P+ cells, a skin cell model used to study tumor promotion. However, at non-toxic concentrations carvedilol dose-dependently inhibited EGF-induced malignant transformation of JB6 P+ cells suggesting that carvedilol has chemopreventive activity against skin cancer. Such effect was not observed for the β-AR agonist isoproterenol and the β-AR antagonist atenolol. Gene expression, receptor binding, and functional studies indicate that JB6 P+ cells only express β2-ARs. Carvedilol, but not atenolol, inhibited EGF-mediated activator protein-1 (AP-1) ...
Carbazole is an aromatic heterocyclic organic compound. It has a tricyclic structure, consisting of two six-membered benzene rings fused on either side of a five-membered nitrogen-containing ring. The compounds structure is based on the indole structure, but in which a second benzene ring is fused onto the five-membered ring at the 2-3 position of indole (equivalent to the 9a-4a double bond in carbazole, respectively ...
Results 36% (37/104) of patients showed a HVPG response to propranolol. Among the propranolol non-responders 56% (38/67) eventually achieved a haemodynamic response with carvedilol, while 44% (29/67) patients were finally treated with EBL. The decrease in HVPG was significantly greater with carvedilol (median 12.5 mg/day) than with propranolol (median 100 mg/day): −19±10% versus −12±11% (p,0.001). During a 2 year follow-up bleeding rates for PROP were 11% versus CARV 5% versus EBL 25% (p=0.0429). Fewer episodes of hepatic decompensation (PROP 38%/CARV 26% vs EBL 55%; p=0.0789) and significantly lower mortality (PROP 14%/CARV 11% vs EBL 31%; p=0.0455) were observed in haemodynamic responders compared to the EBL group.. ...
A study of people who take Carvedilol and have Myocarditis, conducted by eHealthMe with data from FDA and social media (http://www.ehealthme.com/ds/carvedilol/myocarditis). The study analyzes who these people are, when they have Myocarditis and how. eHealthMe updates the study periodically.. Wiki created 2 years 9 months ago ...
Entrega Rápida De México, Reino de España, República de Costa Rica y Todos Los Países!!! Tags: coreg, carvedilol.
Coreg (Carvedilol) is an effective medicine in the treatment of high blood pressure and angina pectoris. Buy Coreg 3.125mg online from MyPillShop.com at best price.
Coreg (Carvedilol) is an effective medicine in the treatment of high blood pressure and angina pectoris. Buy Coreg 3.125mg online from MyPillShop.com at best price.
Shop Ratiopharm Carvedilol tablets 12.5mg 28 online from Healthcare products collection at Mistrys pharmacy. Visit our online store today!
Buy Carved (carvedilol) 25mg, 12.5mg online without prescription in USA, Canada, Australia, UK and Europe. Fast order delivery. Worldwide shipping. FDA approved RX online pharmacy.
Using Yet another NSAID just isnt advisable. Sensitivity to drug-linked adverse reactions may differ with the person patient. Dogs that have expert adverse reactions from a single NSAID could knowledge adverse reactions from Yet another NSAID. Carprofen treatment was not linked with renal toxicity or gastrointestinal ulceration in effectively-controlled safety scientific studies of up to ten occasions the dose in dogs. Carprofen Caplets just isnt advisable to be used in dogs with bleeding Issues (e.g., Von Willebrands illness), as safety hasnt been set up in dogs with these Ailments. The safe utilization of Carprofen Caplets in animals under 6 weeks of age, pregnant dogs, dogs utilized for breeding applications, or in lactating bitches hasnt been founded. Reports to ascertain the exercise of Carprofen when administered concomitantly with other protein-sure or in the same way metabolized medicines have not been done ...
Gold(III)-catalyzed cycloisomerization of α-bis(indol-3-yl)methyl alkynols selectively affords 1-(indol-3-yl)carbazoles, in a transformation that takes place through a selective 1,2-alkyl vs 1,2-vinyl migration step in the vinyl-gold intermediate generated from the initial 5-endo-spirocyclization. The reaction proceeds well with either tertiary or secondary starting alkynols as well as with a wide variety of alkyne substituents. The key role of the other indol-3-yl substituent for the unexpected selectivity in the 1,2 rearrangement has also been supported by DFT calculations that reveal a low barrier, two-step mechanism in the alkyl migration path where the second indole significantly stabilizes a carbocationic intermediate ...
Carbolines: A group of pyrido-indole compounds. Included are any points of fusion of pyridine with the five-membered ring of indole and any derivatives of these compounds. These are similar to CARBAZOLES which are benzo-indoles.
Sibirtsev V.S., Tolmachev A.Yu., Suslov V.V., Garabadzhiu A.V., Traven V.F. Dependence of fluorescence properties of compounds from psoralen, angelicin, and carbazole series on the character of their terminal substituents. // Russian Journal of Organic Chemistry. -2003. -V.39, N.6. -P.881-889 ...
Carvedilol ditelan bersama air putih dengan atau tanpa makanan. Pasien yang mengonsumsi obat ini umumnya harus menjalani diet khusus demi mempertahankan tekanan darah dan berat badan yang ideal. Makanan dengan kadar garam tinggi harus dihindari.. Minumlah obat sesuai instruksi yang diberikan, perhatikan selalu informasi yang tertera pada kemasan obat untuk keterangan mengenai tanggal kedaluarsa atau efek samping obat. Dosis obat dapat berubah sewaktu-waktu sesuai dengan kondisi pasien saat menjalani pemeriksaan rutin. Jangan berhenti minum obat secara tiba-tiba tanpa sepengetahuan dokter. Jika tanpa sengaja meminum obat dalam jumlah yang lebih banyak, segera hubungi dokter atau ke fasilitas kesehatan terdekat.. Bagi pasien yang lupa mengonsumsi carvedilol, disarankan untuk segera mengonsumsinya begitu teringat jika jadwal dan dosis berikutnya tidak terlalu dekat. Jangan menggandakan dosis carvedilol pada jadwal berikutnya untuk menggantikan dosis yang terlewat.. ...
Auro-Carvedilol: Carvedilol belongs to the class of medications called beta-blockers. Carvedilol is used to treat congestive heart failure (CHF), including severe heart failure. It is often taken with a diuretic (water pill) and an angiotensin converting enzyme (ACE) inhibitor.
Provides information on usage, precautions, side effects and brand names when available. Data provided by various government agencies and health-related organizations. ...
Gentaur molecular products has all kinds of products like :search , Biosera \ Goat Serum _ 500 ml \ GO-605/500 for more molecular products just contact us
Gentaur molecular products has all kinds of products like :search , Biosera \ Goat Serum _ 100 ml \ GO-605/100 for more molecular products just contact us
The nonselective beta-adrenoceptor and selective alpha1-adrenoceptor blocker carvedilol is widely used in hypertensive and/or cardiac failure patients. However, there have been few studies regarding the effects of carvedilol on cardiac arrest induced by airway obstruction. The present study was performed to evaluate the effects of beta-blocker during cardiopulmonary resuscitation (CPR) in a rat model of cardiac arrest induced by airway obstruction. Twenty-four male Sprague Dawley rats were used. Animals were randomly assigned to one of two groups (n=12 per group), control group: no medication, treatment group: oral administration of beta-blocker (Carvedilol 10 mg/kg/day) for 5 days. After then, all animals were anesthetized with pentobarbital ip. Cardiac arrest was induced by airway obstruction. After 3 minutes of cardiac arrest, animals were received CPR. The rate of chest compressions (CC) was 240 -260/min in all groups. The rate of ventilation was 32 breaths/min in FIO2 0.21. After 5 minutes ...
The photophysical properties of the new fluorogens were subsequently investigated by UV-vis absorption and photoluminescence (PL) spectroscopy. As depicted in Fig. 1B, CPy showed an absorption maximum at 398 nm in dimethylsulfoxide (DMSO) attributed to ICT from the carbazole moiety to the pyridinium group. The replacement of the pyridinium group with a stronger electron-withdrawing quinolinium unit or the introduction of a strong electron-donating diphenylamine moiety on the carbazole ring both could red shift the absorption of CQu and DCPy to 448 and 458, respectively, again due to the increased ICT effect. In contrast, DCQu with diphenylamine and quinolinium moieties attached at two ends of the carbazole ring displayed further red-shifted and broadened absorption with a maximum at 507 nm, indicating a stronger ICT effect. A gradual bathochromic shift in the absorption of fluorophores from CPy to CQu, then DCPy and DCQu was nicely consistent with the theoretical results discussed above.. The ...
2-(5H-indolo[3,2-c]quinolin-5-yl)ethanamine - chemical structural formula, chemical names, chemical properties, synthesis references
Carbazole is an aromatic heterocyclic organic compound. It has a tricyclic structure, consisting of two six-membered benzene rings fused on either side of a five-membered nitrogen-containing ring. The compounds structure is based on the indole structure, but in which a second benzene ring is fused onto the five-membered ring at the 2-3 position of indole (equivalent to the 9a-4a double bond in carbazole, respectively ...
Citation: Kasanah, N., Rao, K., Yousaf, M., Wedge, D.E., Hill, R.T., Hamann, M.T. 2004. Biotransformation studies of the manzamine alkaloids. Marine Biotechnology. 6:268-272. Interpretive Summary: Manzamines are a group of alkaloids derived from marine sponges that possess a complex heterocyclic ring structure attached to a ß-carboline moiety. The manzamine alkaloids have a diverse range of bioactivity including antitumor and cytotoxicity, anti-inflammatory, antiinfective and antiparasitic, with the greatest potential utility against malaria. Technical Abstract: The manzamines are complex, polycyclic, marine derived alkaloids that are important as pharmaceutical agents due to their activity as antimalarial, antituberculosis, and antitumor drug-leads. In order to understand the metabolism and biogenesis of the manzamines, we examined the biotransformation of manzamine using a number of microorganisms. Our biotransformation studies have focused both on the improvement of the activity and reduced ...
White, green (capsule) pill with GSK Coreg CR 10 mg marking is 24 HR carvedilol phosphate 10 MG Extended Release Capsule [Coreg]. View pill picture, get drug information and see similar-looking pills.
Shop Arrow Generics Carvedilol tablets 12.5mg 28 online from Healthcare products collection at Mistrys pharmacy. Visit our online store today!
The use of One more NSAID is not suggested. Sensitivity to drug-related adverse reactions may differ with the person affected individual. Dogs that have skilled adverse reactions from just one NSAID may knowledge adverse reactions from One more NSAID. Carprofen treatment was not linked with renal toxicity or gastrointestinal ulceration in nicely-controlled safety reports of up to 10 situations the dose in dogs. Carprofen Caplets is not encouraged to be used in dogs with bleeding Ailments (e.g., Von Willebrands disorder), as safety hasnt been established in dogs with these Conditions. The safe usage of Carprofen Caplets in animals less than 6 weeks of age, Expecting dogs, dogs used for breeding uses, or in lactating bitches hasnt been proven. Experiments to find out the exercise of Carprofen when administered concomitantly with other protein-bound or in the same way metabolized medication havent been performed ...
The bioassay data displayed in this panel includes modeled AC50 values from multi-concentration data only. Single concentration data may also be available for some assay technologies. Single concentration data are included in the list of tested assays endpoints if multi-concentration data are unavailable; this can be visualized by searching for a chemical, and clicking "All Tested" in the Assay pane in the Toxcast Dashboard. Raw, normalized, and interpreted single concentration data from level 0 to level 2 are fully available from the freely downloadable MySQL database, invitrodb. Internet Explorer may enable the best functionality to view the Toxcast Dashboard. The scaled response shown on the graph below is calculated by dividing the response values by the activity cutoff thereby enabling response comparisons across assay endpoints ...
Coordination coupling induced self-assembly of ZnS microparticles was performed with the help of a π-conjugated sulphur-terminal Zn(ii) complex ZnS2L (L = N-hexyl-3-{2-[4-2,2′:6′,2′′-terpyridin-4′-yl-phenyl]ethenyl}-carbazole). The interactions between ZnS and ZnS2L components at the interface, which were an
Thank you for sharing this Drug Metabolism & Disposition article.. NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.. ...
RATIONALE: Mutations in the LMNA gene, which encodes the nuclear lamina proteins lamin A and lamin C, are the most common cause of familial dilated cardiomyopathy (DCM). Mechanical stress-induced apoptosis has been proposed as the mechanism underpinning DCM in lamin A/C-deficient hearts, but supporting in vivo evidence has been lacking. OBJECTIVE: Our aim was to study interventions to modify mechanical stress in heterozygous Lmna knockout (Lmna(+/-)) mice. METHODS AND RESULTS: Cardiac structure and function were evaluated before and after exercise training, thoracic aortic constriction, and carvedilol treatment. Lmna(+/-) mice develop adult-onset DCM with relatively more severe disease in males. Lmna(+/-) cardiomyocytes show altered nuclear morphology and perinuclear desmin organization, with enhanced responses to hypo-osmotic stress indicative of cytoskeletal instability. Despite these structural defects that provide a template for mechanical stress-induced damage, young Lmna(+/-) mice ...
The efficacy, tolerance and ease of administration of a nutraceutical, carprofen or meloxicam were evaluated in a prospective, double-blind study on 71 dogs with osteoarthritis. The client-owned dogs were randomly assigned to one of the three treatments or to a placebo control group. The influence of osteoarthritis on the dogs gait was described by comparing the ground reaction forces of the arthritic dogs and 10 normal dogs. Before the treatments began, and 30 and 60 days later, measurements were made of haematological and biochemical variables and of the ground reaction forces of the arthritic limb, and subjective assessments were made by the owners and by the orthopaedic surgeons. Changes in the ground reaction forces were specific to the arthritic joint, and were significantly improved by carprofen and meloxicam but not by the nutraceutical; the values returned to normal only with meloxicam. The orthopaedic surgeons assessed that there had been an improvement with carprofen and meloxicam, ...
Carvedilol is administered as a racemic mixture of the R(+)- and S(-)-enantiomers, although it was demonstrated that the two enantiomers exhibit different pharmacological effects and stereoselective pharmacokinetics. The aim of this study was the evaluation of several native and derivatized cyclodextrines as chiral selectors for the separation of carvedilol enantiomers. Stereoselective interactions were observed with four cyclodextrines (β-CD, hydroxypropyl-β-CD, randomly methylated β-CD and sulfobuthyl ether- β-CD). The effects of CD concentration, pH value and composition of the background electrolyte, capillary temperature, running voltage and injection parameters have been investigated. The method was validated for precision of peak-area response, linearity range and limits of detection and quantification. An efficient stereoselective capillary zone electrophoretic method was developed for the determination of carvedilol enantiomers using a simple 25 mM phosphate buffer at a pH = 2.5 and 10 mM
Background Developing sympathetic neurons depend in nerve growth aspect (NGF) for success and pass away by apoptosis following NGF withdrawal. of most known genes in NGF-deprived sympathetic neurons. We discovered 415 up- and 813 down-regulated genes including a lot of the genes previously regarded as regulated in this technique. NGF drawback activates the blended lineage kinase (MLK)-c-Jun N-terminal kinase (JNK)-c-Jun pathway which is necessary for NGF deprivation-induced loss of life. By including a blended lineage kinase (MLK) inhibitor CEP-11004 inside our experimental style we discovered which from the genes induced after NGF drawback are potential goals from the MLK-JNK-c-Jun pathway. An in depth Gene Ontology and useful enrichment evaluation also identified hereditary pathways that are extremely enriched and overrepresented between the genes portrayed after NGF drawback. Five genes not really previously examined in sympathetic neurons - trib3 ddit3 txnip ndrg1 and mxi1 - had been WYE-354 ...
0608]101: substrate, 102: first electrode, 103: first layer, 104: second layer, 105: third layer, 106: fourth layer, 107: second electrode, 108: EL layer, 130: layer which controls movement of electron carriers, 301: substrate, 302: first electrode, 303: first layer, 304: second layer, 305: third layer, 306: fourth layer, 307: electrode, 308: EL layer, 501: first electrode, 502: second electrode, 511: light-emitting unit, 512: light-emitting unit, 513: charge generation layer, 601: source side driver circuit, 602: pixel portion, 603: gate side driver circuit, 604: sealing substrate, 605: sealant, 607: space, 608: wiring, 610: element substrate, 611: switching TFT, 612: current control TFT, 613: first electrode, 614: insulator, 616: layer containing light-emitting substance, 617: second electrode, 618: light-emitting element, 623: n-channel TFT, 624: p-channel TFT, 901: housing, 902: liquid crystal layer, 903: backlight, 904: housing, 905: driver IC, 906: terminal, 951: substrate, 952: electrode, ...
TY - JOUR. T1 - The inhibition in tumor necrosis factor-α-induced attenuation in endothelial thrombomodulin expression by carvedilol is mediated by nuclear factor-κB and reactive oxygen species. AU - Lin, Pen-Yuan. AU - Shen, Hsi Che. AU - Chen, Chien Jen. AU - Wu, Shu En. AU - Kao, Hsien Li. AU - Huang, Jen-Hung. AU - Wang, Danny Ling. AU - Chen, Shih-Chung. PY - 2010/1. Y1 - 2010/1. N2 - Carvedilol, a nonselective β-adrenoceptor antagonist, has been shown to possess antioxidant effects and reduce the risk of hospitalization and death in patients with severe congestive heart failure, which is featured by the activation of pro-inflammatory cytokines, including tumor necrosis factor-α (TNF-α), and leads to thrombotic complications. Thrombomodulin (TM) plays protective roles against thrombosis. Treatment of ECs with TNF-α resulted in a down-regulation in the TM expression in a time-dependent manner. Pre-treatment of ECs with carvedilol (1 and 10 μM) for 1 h significantly up-regulated the TM ...
Purpose: Vascular endothelial growth factor (VEGF) plays a central role in the development of retinal neovascularization and vascular leakage in diabetic retinopathy. Anti-VEGF therapy is widely used for these pathological conditions. However, frequent intravitreal injections are needed for maximum effect. In this study, we investigated the therapeutic potential of the topical ROCK (Rho-associated protein kinase) inhibitor K-115 in pathological retinal neovascularization and vascular leakage.. Methods: In vitro, human retinal microvascular endothelial cells (HRVECs) were pretreated with K-115 (3µM, 30µM), and then stimulated with human recombinant VEGF (25ng/ml). Migration and proliferation ability were assessed by cell migration and proliferation assay, respectively. The expression and localization of tight junction proteins (occludin/claudin) were evaluated by western blotting and immunohistochemistry, respectively. In vivo, normal saline vehicle, 0.4% or 0.8% K-115 eye drops were ...
Heart failure (HF) and benign prostatic hypertrophy (BPH) are two conditions that commonly coexist in men 60 years and older. Carvedilol is the only β-adrenergic blocker approved for HF that also has additional α1-adrenergic blockade. As α1-adrene

Apoptosis Effect of Girinimbine Isolated from Murraya koenigii on Lung Cancer Cells In VitroApoptosis Effect of Girinimbine Isolated from Murraya koenigii on Lung Cancer Cells In Vitro

The current study investigated the anticancer effects of girinimbine, a carbazole alkaloid isolated from ,i,Murraya koenigii,/i ... 1999) had reported that carbazole alkaloids obtained from M. koenigii show cytotoxic capacity [11]. Even though many carbazole ... Apart from these, many carbazole alkaloids also have been identified. It has been reported that carbazole alkaloids present in ... The current study found that girinimbine, a carbazole alkaloid from the roots of M. koenigii, can inhibit cell proliferation ...
more infohttps://www.hindawi.com/journals/ecam/2013/689865/

Anti-diabetic effect of Murraya koenigii (L) and Olea europaea (L) leaf extracts on streptozotocin induced diabetic rats - PDFAnti-diabetic effect of Murraya koenigii (L) and Olea europaea (L) leaf extracts on streptozotocin induced diabetic rats - PDF

Metabolism, 49: Chakrabarty M, Nath A and Khasnobis S (199). Carbazole alkaloids from Murraya koenigii. Phytochemistry, 46: ... carbazole alkaloid) from Murraya koenigii (rutaceae) leaves. IJOP, 2: -30. Fki I, Sahnoun Z and Sayadi S (200). ... carbazole alkaloids, triterpenoids, mineral contents such as iron, calcium, zinc and vanadium, and phenolic compounds ( ... which could be due to the free radical scavenging effect of carbazole alkaloids present in the leaves (Tachibana et al., 2003 ...
more infohttp://docplayer.net/24140891-Anti-diabetic-effect-of-murraya-koenigii-l-and-olea-europaea-l-leaf-extracts-on-streptozotocin-induced-diabetic-rats.html

Ellipticine derivatives: targeting cell proliferation by a structured approachEllipticine derivatives: targeting cell proliferation by a structured approach

... maintaining the carbazole core. This work was extended further, examining the use of benzofuran as a starting material, in ...
more infohttps://cora.ucc.ie/handle/10468/7780

Carbazole analytical standard | Sigma-AldrichCarbazole analytical standard | Sigma-Aldrich

Carbazole; Refer to the product ′s Certificate of Analysis for more information on a suitable instrument technique. Contact ... Carbazoles belong to the family of polycyclic aromatic hydrocarbons (PAHs) compounds. Application Carbazole may be used as a ... reference standard for the determination of carbazole in:. • e-cigarette aerosols by thermal desorption-gas chromatography- ...
more infohttps://www.sigmaaldrich.com/catalog/product/supelco/442506?lang=en®ion=US

Optical and electrochemical cations recognition and release from N-azacrown carbazoles | SpringerLinkOptical and electrochemical cations recognition and release from N-azacrown carbazoles | SpringerLink

Two azacrown derivatives of carbazole have been prepared and their dipole moments in the excited state were estimated from ... Fluorescence Spectrum Perchlorate Oxidation Peak Carbazole Oxidation Potential These keywords were added by machine and not by ... Two azacrown derivatives of carbazole have been prepared and their dipole moments in the excited state were estimated from ... From the study of the longer lived radical-cation of the azacrown carbazoles, generated electrochemically, the metal cations ...
more infohttps://link.springer.com/article/10.1163%2F156856701745104

Novel Complex Polymers with Carbazole Functionality by Controlled Radical PolymerizationNovel Complex Polymers with Carbazole Functionality by Controlled Radical Polymerization

... Kazuhiro Nakabayashi and Hideharu ... Kazuhiro Nakabayashi and Hideharu Mori, "Novel Complex Polymers with Carbazole Functionality by Controlled Radical ...
more infohttps://www.hindawi.com/journals/ijps/2012/170912/cta/

2-Nitro-9H-carbazol-3-amine | C12H9N3O2 - PubChem2-Nitro-9H-carbazol-3-amine | C12H9N3O2 - PubChem

2-Nitro-9H-carbazol-3-amine , C12H9N3O2 , CID 4023072 - structure, chemical names, physical and chemical properties, ...
more infohttps://pubchem.ncbi.nlm.nih.gov/compound/4023072

Carbazole acetic acid derivatives - Patent # 4178289 - PatentGeniusCarbazole acetic acid derivatives - Patent # 4178289 - PatentGenius

... alkyl carbazole-2-oxalate, inter alia, is also described. ... Preparation of carbazole-2-oxalic acid methyl ester. A stirred ... Preparation of ethyl carbazole-2-oxalate. To a stirred suspension of 167.2 g. of carbazole in 400 ml. of methylene chloride was ... gave 181 g. of ethyl carbazole-2-oxalate as a gold powder, sintering at 130.degree.,m.p. 130.5-131.5.degree... EXAMPLE 2. ... In a first aspect, the invention relates to a process for preparing carbazole-2-oxalic acid lower alkyl ester by a process ...
more infohttp://www.patentgenius.com/patent/4178289.html

7H-Dibenzo(c,g)Carbazole (IARC Summary & Evaluation, Volume 3, 1973)7H-Dibenzo(c,g)Carbazole (IARC Summary & Evaluation, Volume 3, 1973)

7H-DIBENZO(c,g)CARBAZOLE. VOL.: 3 (1973) (p. 260). 5. Summary of Data Reported and Evaluation. 5.1 Animal carcinogenicity data ... 7H-Dibenzo(c,g)carbazole is carcinogenic in the mouse, rat, hamster and possibly in the dog. It has both a local and systemic ... In comparison with benzo(a)pyrene, 7H-dibenzo(c,g)carbazole appears to be a stronger respiratory tract carcinogen for the ... No case reports or epidemiological studies on the significance of 7H-dibenzo(c,g)carbazole exposure to man are available. The ...
more infohttp://inchem.org/documents/iarc/vol03/7h-dibenzo

Carbazole - WikipediaCarbazole - Wikipedia

In the third step, this compound is oxidized by red lead to carbazole itself. Another classic is the Bucherer carbazole ... Carbazole is a constituent of tobacco smoke. A classic laboratory organic synthesis for carbazole is the Borsche-Drechsel ... Carbazole is an aromatic heterocyclic organic compound. It has a tricyclic structure, consisting of two six-membered benzene ... A second method for the synthesis of carbazole is the Graebe-Ullmann reaction. In the first step, an N-phenyl-1,2- ...
more infohttps://en.wikipedia.org/wiki/Carbazole

Investigation of carbazole degradation by the sono-Fenton process on Environmental XPRTInvestigation of carbazole degradation by the sono-Fenton process on Environmental XPRT

Article Investigation of carbazole degradation by the sono-Fenton process. The present report aimed to describe the roles of ... ultrasonic power and reaction time in the Fenton reagent-based degradation of carbazole in wastewater, and to analyze the eff ... Investigation of carbazole degradation by the sono-Fenton .... Investigation of carbazole degradation by the sono-Fenton ... No comments were found for Investigation of carbazole degradation by the sono-Fenton process. Be the first to comment! ...
more infohttps://www.environmental-expert.com/articles/investigation-of-carbazole-degradation-by-the-sono-fenton-process-388115

3-((2-Chloro-4-nitrophenyl)azo)-9H-carbazole | C18H11ClN4O2 - PubChem3-((2-Chloro-4-nitrophenyl)azo)-9H-carbazole | C18H11ClN4O2 - PubChem

9H-carbazole , C18H11ClN4O2 , CID 116535 - structure, chemical names, physical and chemical properties, classification, patents ...
more infohttps://pubchem.ncbi.nlm.nih.gov/compound/116535

Materials | Free Full-Text | Synthesis, Characterization and Photophysical Properties of Pyridine-Carbazole Acrylonitrile...Materials | Free Full-Text | Synthesis, Characterization and Photophysical Properties of Pyridine-Carbazole Acrylonitrile...

Synthesis, Characterization and Photophysical Properties of Pyridine-Carbazole Acrylonitrile Derivatives by Enrique Pérez- ... "Synthesis, Characterization and Photophysical Properties of Pyridine-Carbazole Acrylonitrile Derivatives." Materials 4, no. 3: ... Characterization and Photophysical Properties of Pyridine-Carbazole Acrylonitrile Derivatives. Materials 2011, 4, 562-574. ... Characterization and Photophysical Properties of Pyridine-Carbazole Acrylonitrile Derivatives. Materials. 2011; 4(3):562-574. ...
more infohttps://www.mdpi.com/1996-1944/4/3/562

Highly selective CO2 adsorption performance of carbazole based microporous polymers - RSC Advances (RSC Publishing)Highly selective CO2 adsorption performance of carbazole based microporous polymers - RSC Advances (RSC Publishing)

Non-coplanar shaped carbazole based monomers were used to synthesize microporous polycarbazole materials utilizing an ... Highly selective CO2 adsorption performance of carbazole based microporous polymers M. Saleh and K. S. Kim, RSC Adv., 2015, 5, ... Non-coplanar shaped carbazole based monomers were used to synthesize microporous polycarbazole materials utilizing an ... Introduction of the electron rich carbazole structure into the aromatic system and pore geometry contribute to higher ...
more infohttp://pubs.rsc.org/en/content/articlelanding/2015/ra/c5ra06767g?iscitedby=True

Chemical Database: Ammonium, hexamethylenebis((beta-carbazol-9-ylethyl)dimethyl-, dibromide (EnvironmentalChemistry.com)Chemical Database: Ammonium, hexamethylenebis((beta-carbazol-9-ylethyl)dimethyl-, dibromide (EnvironmentalChemistry.com)

... beta-carbazol-9-ylethyl)dimethyl-, dibromide including: 4 synonyms/identifiers. ... Ammonium, hexamethylenebis((beta-carbazol-9-ylethyl) dimethyl-, dibromide*Hexamethylenebis(2-carbazol-9-ylethyl) ... Ammonium, hexamethylenebis((beta-carbazol-9-ylethyl) dimethyl-, dibromide. Identifications. *CAS Number: 63982-08-1*Synonyms/ ... 1,6-Hexanediaminium, N,N-bis(2-(9H-carbazol-9-yl) ethyl)-N,N,N,N-tetramethyl-, dibromide* ...
more infohttps://environmentalchemistry.com/yogi/chemicals/cn/Ammonium%2C%A0hexamethylenebis%28%28beta-carbazol-9-ylethyl%29dimethyl-%2C%A0dibromide.html

Bucherer carbazole synthesis - WikipediaBucherer carbazole synthesis - Wikipedia

The Bucherer carbazole synthesis is a chemical reaction used to synthesize carbazoles from naphthols and aryl hydrazines using ...
more infohttps://en.wikipedia.org/wiki/Bucherer_carbazole_synthesis

Cas 37500-95-1,3,6-BIS(TERT-BUTYL)CARBAZOLE | lookchemCas 37500-95-1,3,6-BIS(TERT-BUTYL)CARBAZOLE | lookchem

We also Provide Trading Suppliers & Manufacture for 37500-95-1 3,6-BIS(TERT-BUTYL)CARBAZOLE. ... Product Name: 3,6-BIS(TERT-BUTYL)CARBAZOLE. *Synonyms: 3,6-BIS(TERT-BUTYL)CARBAZOLE;3,6-Di-tert-butyl-9H-carbazole;3,6-Ditert- ... butyl-9H-carbazole;3,6-Di-tert-butylcarbazole;9H-Carbazole, 3,6-bis(1,1-diMethylethyl)-;3,6-Di-tert-butylcarbazole≥ 99% (GC) ... 3,6-Bis-(tert-butyl)-9H-carbazole. Cas No: 37500-95-1. No Data. No Data. No Data. Chemwill Asia Co., Ltd.. Contact Supplier ...
more infohttps://www.lookchem.com/casno37500-95-1.html

Federal Register
       :: 
      Carbazole Violet Pigment 23 from India: Preliminary Results of Antidumping Duty...Federal Register :: Carbazole Violet Pigment 23 from India: Preliminary Results of Antidumping Duty...

... is conducting an administrative review of the antidumping duty order on carbazole violet pigment 23 from India. The review ... See Carbazole Violet Pigment 23 From India: Extension of Time Limit for Preliminary Results of Antidumping Start Printed Page ... Carbazole Violet Pigment 23 from India: Preliminary Results of Antidumping Duty Administrative Review. A Notice by the ... See Carbazole Violet Pigment 23 From India: Final Results of Antidumping Duty Administrative Review, 73 FR 74141 (December 5, ...
more infohttps://www.federalregister.gov/documents/2009/12/22/E9-30434/carbazole-violet-pigment-23-from-india-preliminary-results-of-antidumping-duty-administrative-review

11H-Benzo[a]carbazole 239-01-0 | TCI America11H-Benzo[a]carbazole 239-01-0 | TCI America

11H-Benzo[a]carbazole] [239-01-0] , Buy and find out price and availability, MSDS, properties of TCIs high quality specialty ... 11H-Benzo[a]carbazole. (CAS RN:239-01-0 Product Number:B4635). Structure. ...
more infohttp://www.tcichemicals.com/eshop/en/us/commodity/B4635/

2-TRIFLUOROMETHYL-9H-CARBAZOLE (CAS 2285-35-0) Market Research Report 20182-TRIFLUOROMETHYL-9H-CARBAZOLE (CAS 2285-35-0) Market Research Report 2018

Market Research Report 2018 aims at providing comprehensive data on 2-trifluoromethyl-9h-carbazole market ... 2-trifluoromethyl-9h-carbazole prices in other regions. 7. 2-TRIFLUOROMETHYL-9H-CARBAZOLE END-USE SECTOR 7.1. 2-trifluoromethyl ... 2-trifluoromethyl-9h-carbazole market forecast. 6. 2-TRIFLUOROMETHYL-9H-CARBAZOLE MARKET PRICES. 6.1. 2-trifluoromethyl-9h- ... carbazole prices in Europe. 6.2. 2-trifluoromethyl-9h-carbazole prices in Asia 6.3. 2-trifluoromethyl-9h-carbazole prices in ...
more infohttps://marketpublishers.com/report/industry/chemicals_petrochemicals/2-trifluoromethyl-9h-carbazole_2285-35-0_market_research_report.html

7H-DIBENZO (c.g) CARBAZOLE (purity)- CAS Number 194-59-27H-DIBENZO (c.g) CARBAZOLE (purity)- CAS Number 194-59-2

CARBAZOLE (purity) - CAS Number 194-59-2 from LGC Standards. Please login or register to view prices, check availability and ...
more infohttps://www.lgcstandards.com/DE/en/7H-DIBENZO-c-g-CARBAZOLE-purity-/p/BCR-266

Molecules | Free Full-Text | Recent Developments and Biological Activities of N-Substituted Carbazole Derivatives: A ReviewMolecules | Free Full-Text | Recent Developments and Biological Activities of N-Substituted Carbazole Derivatives: A Review

A series of carbazole derivatives such as N-substituted carbazoles, benzocarbazoles, furocarbazoles, pyrrolocarbazoles, ... Herein an attempt is made to review the medicinal importance of recently synthesized N-substituted carbazoles. ... Carbazoles represent an important class of heterocycles. These have been reported to exhibit diverse biological activities such ... Keywords: N-substituted carbazoles; antimicrobial; anticancer; neuroprotective N-substituted carbazoles; antimicrobial; ...
more infohttps://www.mdpi.com/1420-3049/20/8/13496

6-Formylindolo(3,2-b)carbazole (CAS 172922-91-7) 95% purity (ab141631) |Abcam6-Formylindolo(3,2-b)carbazole (CAS 172922-91-7) 95% purity (ab141631) |Abcam

... carbazole, Aryl hydrocarbon receptor ligand (CAS 172922-91-7), with ,95% purity. Join researchers using our high quality ... Functional Studies - 6-Formylindolo(3,2-b)carbazole, Aryl hydrocarbon receptor ligand (ab141631)Bunaciu et al PLoS One. 2015; ...
more infohttps://www.abcam.com/6-formylindolo32-bcarbazole-aryl-hydrocarbon-receptor-ligand-ab141631.html
  • The current study investigated the anticancer effects of girinimbine, a carbazole alkaloid isolated from Murraya koenigii Spreng, on A549 lung cancer cells in relation to apoptotic mechanistic pathway. (hindawi.com)
  • methylcarbazole-2-acetic acid and lower alkyl carbazole-2-oxalate, inter alia, is also described. (patentgenius.com)
  • In a first aspect, the invention relates to a process for preparing carbazole-2-oxalic acid lower alkyl ester by a process which comprises the steps of (a) acylating carbazole to yield a 9-alkanoylcarbazole, which is subsequently treated with alower alkyl oxalyl halide to yield 9-alkanoylcarbazole-2-oxalic acid lower alkyl ester and (b) deacylating the product of step (a) to yield carbazole-2-oxalic acid lower alkyl ester. (patentgenius.com)
  • Kazuhiro Nakabayashi and Hideharu Mori, "Novel Complex Polymers with Carbazole Functionality by Controlled Radical Polymerization," International Journal of Polymer Science , vol. 2012, Article ID 170912, 18 pages, 2012. (hindawi.com)
  • When compared to known methods for the synthesis of N -substituted carbazoles from 2-amidobiaryls, this protocol is practical, efficient and does not require a transition metal catalyst or toxic organic solvents. (rsc.org)
  • Electrodeposition of carbazole dendrons afforded a globular supramolecular conformation in which the mesogenic molecular side plays a key role. (csic.es)
  • Carbazoles represent an important class of heterocycles. (mdpi.com)
  • The synthesis and characterisation of a family of block codendrimers consisting of highly versatile mesogenic and carbazole-containing 2,2-bis(hydroxymethyl)propionic acid (bis-MPA) dendrons are reported. (csic.es)