Carbazilquinone: An alkylating agent structurally similar to MITOMYCIN and found to be effective in the treatment of leukemia and various other neoplasms in mice. It causes leukemia and thrombocytopenia in almost all human patients.Lung Neoplasms: Tumors or cancer of the LUNG.Carcinoma, Non-Small-Cell Lung: A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.Biological Science Disciplines: All of the divisions of the natural sciences dealing with the various aspects of the phenomena of life and vital processes. The concept includes anatomy and physiology, biochemistry and biophysics, and the biology of animals, plants, and microorganisms. It should be differentiated from BIOLOGY, one of its subdivisions, concerned specifically with the origin and life processes of living organisms.Cell Line, Tumor: A cell line derived from cultured tumor cells.Bone Marrow: The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.Antineoplastic Agents: Substances that inhibit or prevent the proliferation of NEOPLASMS.Ethyl Chloride: A gas that condenses under slight pressure. Because of its low boiling point ethyl chloride sprayed on skin produces an intense cold by evaporation. Cold blocks nerve conduction. Ethyl chloride has been used in surgery but is primarily used to relieve local pain in sports medicine.Color Perception Tests: Type of vision test used to determine COLOR VISION DEFECTS.Color Vision Defects: Defects of color vision are mainly hereditary traits but can be secondary to acquired or developmental abnormalities in the CONES (RETINA). Severity of hereditary defects of color vision depends on the degree of mutation of the ROD OPSINS genes (on X CHROMOSOME and CHROMOSOME 3) that code the photopigments for red, green and blue.Tankyrases: A group of telomere associated proteins that interact with TRF1 PROTEIN, contain ANKYRIN REPEATS and have poly(ADP-ribose) polymerase activity.Carbohydrate Epimerases: Enzymes that catalyze the epimerization of chiral centers within carbohydrates or their derivatives. EC 5.1.3.Color Perception: Mental processing of chromatic signals (COLOR VISION) from the eye by the VISUAL CORTEX where they are converted into symbolic representations. Color perception involves numerous neurons, and is influenced not only by the distribution of wavelengths from the viewed object, but also by its background color and brightness contrast at its boundary.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.AKR murine leukemia virus: A strain of Murine leukemia virus (LEUKEMIA VIRUS, MURINE) isolated from spontaneous leukemia in AKR strain mice.Bibliography as Topic: Discussion of lists of works, documents or other publications, usually with some relationship between them, e.g., by a given author, on a given subject, or published in a given place, and differing from a catalog in that its contents are restricted to holdings of a single collection, library, or group of libraries. (from The ALA Glossary of Library and Information Science, 1983)Bibliography of Medicine: A list of works, documents, and other publications on medical subjects and topics of interest to the field of medicine.MississippiBibliographyWood: A product of hard secondary xylem composed of CELLULOSE, hemicellulose, and LIGNANS, that is under the bark of trees and shrubs. It is used in construction and as a source of CHARCOAL and many other products.Dog Diseases: Diseases of the domestic dog (Canis familiaris). This term does not include diseases of wild dogs, WOLVES; FOXES; and other Canidae for which the heading CARNIVORA is used.

Essential thrombocythemia transformed to acute myelogenous leukemia with t(3;17)(p24; q12), del(5)(q13q34) after treatment with carboquone and hydroxyurea. (1/12)

In 1991, a 52-year-old woman was diagnosed as having essential thrombocythemia (ET). She was doing well with continuous medication with carboquone (CQ) and subsequently hydroxyurea (HU). However, substantial leukocytosis with leukemic blast cells, anemia and thrombocytopenia developed in 1996. Analysis of peripheral blood showed 4.4 x 10(3)/microl white blood cells with 82% of leukemic blast cells. These blasts showed negative staining with myeloperoxidase by immunostaining, but the myeloperoxidase was positive by electron microscopic analysis. Cytogenetic analysis of bone marrow cells revealed a t(3;17)(p24; q12), del(5)(q13q34). On the basis of these findings, the leukemic blast cells were classified as acute myelogenous leukemia (AML:M0) in the FAB classification. The causative agent, CQ and HU in secondary leukemia from ET and chromosomal abnormality related to ET blastic crisis (BC) are discussed.  (+info)

Essential thrombocythemia developing into refractory anemia and complicated by acute myeloid leukemia. (2/12)

We report a case of essential thrombocythemia (ET) that climaxed in acute myeloid leukemia after developing into refractory anemia. The male patient had ET that was stable for 8 years on carboquone therapy. However, at the age of 72 years he developed an acute terminal illness that was characterized by severe pancytopenia, circulating myeloblasts, extensive bone marrow infiltration by myeloblasts, and an abnormal karyotype [46, XY, t(8q-; 20q+)]. He subsequently died of severe bilateral pneumonia and heart failure. This case suggests that ET may be similar to polycythemia vera; progression to leukemia is unusual except after chemotherapy. Therefore, treatment of patients with asymptomatic ET may not be advisable.  (+info)

Application of a self-organizing map to quantitative structure-activity relationship analysis of carboquinone and benzodiazepine. (3/12)

Self-organizing map (SOM) of Kohonen seems to be a promising approach beyond the standard one to regression for some classification problems encountered in the field of pharmacy. We apply them, therefore, to the quantitative structure-activity relationship (QSAR) in carboquinones and benzodiazepines, and show their usefulness. Most QSAR analysis using neural networks has been made by adopting neural networks with supervised learning. On the contrary, SOM obeys unsupervised learning and originally does not involve the use of desired target data. If we note that an appreciable fraction of data may be missing without making the similarity comparison impossible in SOM if the number of attributes considered is appreciable, QSAR analysis using SOM is found to be possible as if supervised learning. Similar to target data in supervised learning, we can take into account target data (=observed activity) as one of attributes in addition to other attributes (=structural descriptors). Choice of optimal descriptors as input parameters was found to be essential to generate valuable SOM.  (+info)

Comparison of quantitative structure-activity relationship model performances on carboquinone derivatives. (4/12)

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Quenching enhancement of the singlet excited state of pheophorbide-a by DNA in the presence of the quinone carboquone. (5/12)

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Effect of chemotherapy on natural-killer activity and antibody-dependent cell-mediated cytotoxicity in carcinoma of the lung. (6/12)

The effect of chemotherapy on natural killer (NK) activity and antibody-dependent cell-mediated cytotoxicity (ADCC) in 15 advanced carcinomas of the lung was examined with regard to the drug, dose, route and timing of administration. The relationship between the effect of chemotherapy on the prognosis for the patients, and the changes in NK activity and ADCC, was also analysed. The NK activity and ADCC in patients with poor prognosis were significantly subnormal, even before treatment. The NK activity and ADCC began to decrease 2 weeks after the initiation of treatment and reached the lowest level during the 3rd or 4th week in all patients. Thereafter, they returned to the pretreatment level in 8 patients with stabilized disease. In contrast, they were not restored in 7 patients with progressive disease and poor prognosis. In 4 patients it was found that the effect of chemotherapy with pepleomycin and carbazilquinone on NK activity and ADCC differed according to the drug used. From this pilot study it is suggested that NK activity and ADCC are valuable prognostic factors in patients with advanced carcinoma of the lung, and that detailed analysis of the effect of each anticancer agent on NK activity and ADCC is desirable for the establishment of better treatment regimens for advanced carcinoma of the lung.  (+info)

Damage of DNA and its recovery in AH-109A cells treated with carboquone in vivo. (7/12)

A single injection of carboquone at a dose of 0.1 mg/kg body weight induced damage of DNA of AH-109A cells as revealed by alkaline and neutral sucrose density gradient centrifugation. A significant decrease in the sedimentation velocity of DNA on alkaline sucrose density gradient centrifugation was observed 15 min after the injection, and it returned to that of control after 60 min. Thereafter, the size of DNA decreased progressively. When the cells were lysed with 2% sodium dodesyl sulfate solution and analyzed on neutral sucrose density gradient centrifugation, a similar change in the sedimentation velocity was observed. The results obtained from the studies of intraperitoneal growth of AH-109A cells pretreated with carboquone in vivo and the survival of host animals well corresponded to the extent of the damage of DNA as revealed by alkaline and neutral sucrose density gradient centrifugation.  (+info)

Combination chemotherapy in advanced ovarian cancer. (8/12)

Among the 95 cases of ovarian cancer treated by us between May, 1975 and August, 1978, only 33 were suitable for complete resection. The remaining 62 cases underwent incomplete resection, followed by F.Q.C. combination chemotherapy (1-(2-tetrahydrofuryl)-5-fluorouracil, carbazilquinone, cytosine arabinoside); 54.8% showed an antitumor response. The median survival time of the responders was 13.2 months, whereas it was 7.4 months for the non-responders. The survival rate after 24 months, however, was 13% and 4%, respectively. Side effects of the drugs, including leucopenia, thrombocytopenia, nausea and vomiting, were found in roughly one half of the cases.  (+info)

Quantitative Structure-Activity Relationship (QSAR) Models of Mutagens and Carcinogens von Romualdo Benigni und Buchbewertungen gibt es auf ReadRate.com. Bücher können hier direkt online erworben werden.
The cardiac toxicity of arsenic trioxide (ATO) was studied in chick embryos. Fertilized eggs of White Leghorns were incubated and investigated. The chick embryonic heart has been often used in pharmacologic and toxicologic experiments. After ATO at 0.25, 0.5 or 1.0 mg/egg was injected into fertilized eggs, heart rates (HRs) were measured by electrocardiogram. After low dosing of ATO, the heart rate was not different compared with control. However, HRs significantly decreased in a dose- and time-dependent manner ( ...
Structure-Based and Multiple Potential Three-Dimensional Quantitative Structure-Activity Relationship (SB-MP-3D-QSAR) for Inhibitor Design
TY - JOUR. T1 - Cluster validity and uncertainty assessment for self-organizing map pest profile analysis. AU - Roigé, Mariona. AU - McGeoch, Melodie A.. AU - Hui, Cang. AU - Worner, Susan P.. PY - 2017/3/1. Y1 - 2017/3/1. N2 - Pest risk assessment (PRA) comprises a set of quantitative and qualitative tools to protect productive ecosystems from the impacts of unwanted biological invasions. Self-organizing maps for pest profile analysis (SOM PPA) is a methodological approach aimed to support PRA. It is based on cluster analysis and extracts information out of current distributions of insect crop pests world-wide, allowing the analyst to generate a list of potential risk species for a target region. Self-organizing maps for pest profile analysis currently lacks of a measure of performance able to provide a level of confidence for its outputs. In this study, we investigate ζ diversity as an ecologically meaningful and generalizable metric of similarity. The application of ζ allowed us to ...
Kohonen self-organizing maps (SOMs) are unsupervised Artificial Neural Networks (ANNs) that are good for low-density data visualization. They easily deal with complex and nonlinear relationships between variables. We evaluated molecular events that characterize high- and low-grade BC pathways in the tumors from 104 patients. We compared the ability of statistical clustering with a SOM to stratify tumors according to the risk of progression to more advanced disease. In univariable analysis, tumor stage (log rank P = 0.006) and grade (P | 0.001), HPV DNA (P | 0.004), Chromosome 9 loss (P = 0.04) and the A148T polymorphism (rs 3731249) in CDKN2A (P = 0.02) were associated with progression. Multivariable analysis of these parameters identified that tumor grade (Cox regression, P = 0.001, OR.2.9 (95% CI 1.6-5.2)) and the presence of HPV DNA (P = 0.017, OR 3.8 (95% CI 1.3-11.4)) were the only independent predictors of progression. Unsupervised hierarchical clustering grouped the tumors into discreet branches
Self-organizing maps were trained to separate high- and low-active propafenone-type inhibitors of P-glycoprotein. The trained maps were subsequently used to identify highly active compounds in a virtual screen of the SPECS compound library.. ...
CODESSA PROTM (Comprehensive Descriptors for Structural and Statistical Analysis) is a comprehensive program for developing quantitative structure-activity/property relationships (QSAR/QSPR) that integrates all necessary mathematical and computational tools to:. ...
The first Proton Sales Carnival, held in Shah Alam, garnered 396 bookings. The Melaka carnival managed 727, while the Penang carnival achieved 879.
Diarylquinolines, synthesis pathways and quantitative structure-activity relationship studies leading to the discovery of TMC207 ...
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Data and research on test guidelines including chemical testing and assessment, chemical safety, animal welfare, endocrine disrupters, good laboratory practice (GLP), Mutual Acceptance of Data (MAD)., In November 2004, the OECD member countries agreed on the principles for validating (quantitative) structure-activity relationship [(Q)SAR] models for their use in regulatory assessment of chemical safety. (Q)SARs are methods for estimating the toxicity and other properties of a chemical from its molecular structure.
A set of 3 beta-(4-substituted phenyl)-2 beta-heterocyclic tropanes was designed, synthesized, and characterized. We discovered that these compounds can function as bioisosteric replacements for the corresponding WIN 35,065-2 analogs which possess a 2 beta-carbomethoxy group. Several of the compounds showed high affinity and selectivity for the dopamine transporter (DAT)
A quantitative structure-activity relationship (QSAR) study of IRAK inhibitor 6 and its analogs were conducted by using the genetic algorithm and multiple linear regression (GA-MLR) method. In vitro study showed that compared with its unsubstituted phenyl amide analog, the ortho-substitution with chloro, methoxy and difluoromethoxy analogs of IRAK inhibitor 6 improved potency against IRAK-4 significantly. These potency effects were additive, with the most active example in the set being IRAK inhibitor 6, in which the presence of nitrogen-linked substituents at the para position had a beneficial effect on the rate of turnover by human microsomes (20 μL/min/mg protein ...
The antioxidant potency of 17β-estradiol and related polycyclic phenols has been well established. This property is an important component of the complex events by which these types of agents are capable to protect neurons against the detrimental consequences of oxidative stress. In order to relate their molecular structure and properties with their capacity to inhibit lipid peroxidation, a marker of oxidative stress, quantitative structure-activity relationship (QSAR) studies were conducted. The inhibition of Fe3+-induced lipid peroxidation in rat brain homogenate, measured through an assay detecting thiobarbituric acid reactive substances for about seventy compounds were correlated with various molecular descriptors. We found that lipophilicity (modeled by the logarithm of the n-octanol/water partition coefficient, logP) was the property that influenced most profoundly the potency of these compounds to inhibit lipid peroxidation in the biological medium studied. Additionally, the important
CYP2C9 is one of our major drug metabolising enzymes and belongs to the cytochrome P450 (CYP) super family. The aim of this thesis was to gain an understanding of the quantitative structure-activity relationships (QSAR) of CYP2C9 substrates and inhibitors. This information will be useful in predicting drug metabolism and the potential for drug-drug interactions. To achieve this, a well characterised data set of structurally diverse, competitive CYP2C9 inhibitors was identified in our laboratory. Several computational methodologies, many based on GRID molecular interaction fields, were applied or developed in order to handle issues such as compound alignment and bioactive conformer selection. First, a traditional 3D QSAR was carried out in GOLPE, generating a predictive model. In this model the selection of a bioactive conformer and alignment was based on docking in a homology model of CYP2C9. Secondly, we introduced the concept of alignment independent descriptors from ALMOND. These descriptors ...
1LPG: Design and Quantitative Structure-Activity relationship of 3-amidinobenzyl-1H-indole-2-carboxamides as potent, nonchiral, and selective inhibitors of blood coagulation factor Xa.
This Histri was built automatically but not manually verified. As a consequence, the Histri can be incomplete or can contain errors ...
This study assessed the presentation, treatment, and prognosis of primary gastric lymphoma in general hospital practice and its relation to infection with Helicobacter pylori. The number of patients that would on the current recommendations have been suitable for H pylori eradication therapy was also examined. All lymphomas were graded according to a standard classification of gut lymphoma into high and low grade disease. Forty five patients (mean age 65 years) were identified. The overall five year survival was 40% with a trend in favour of an improved prognosis for low grade and stage I disease. H pylori was present in 80%. Only one of 18 patients with a low grade mucosa associated lymphoid tissue tumour had mucosal disease alone, which responded to omeprazole and amoxycillin. All other patients had bulk disease. These patients were treated by surgery, chemotherapy or radiotherapy or a combination of these treatments. In district hospital practice, most cases of primary gastric lymphoma have ...
Thank you for sharing this Journal of Pharmacology and Experimental Therapeutics article.. NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.. ...
TY - JOUR. T1 - Investigation of antiulcer activities of imidazo[1,2-α]pyridinyl-2-alkylaminobenzoxazoles and 5,6,7,8-tetahydroimidazo[1,2-α]pyridinylbenzoxazoles with electron-topological (ET) method. AU - Huang, Hsu Shan. AU - Chiou, Jeng Fong. AU - Chiu, Hui Fen. AU - Chen, Rong Fu. AU - Lai, Yu Liang. PY - 2002. Y1 - 2002. N2 - The study presents structure-activity considerations of a series of imidazo[1,2-α]pyridiny-2-alkylaminobenzoxazoles(I) and 5,6,7,8-tetahydroimidazo[1,2-α]pyridinylbenzoxazoles (II) investigated for anti-stress ulcer activity with the electron-topological method. A series of 39 compounds including 24 active and 15 weakly active was studied. It is shown that the fragment determined by the electron-topological method in an active molecule is responsible for anti-stress ulcer activity. Quantitative structure-activity relationships with electron topological approach of these compounds are discussed in terms of the statistical program STATGRAF-7.0.. AB - The study ...
OGAWA Yoshinari , CHUNG Yong-Suk , NAKATA Bunzo , MUGURUMA Kazuya , FUJIMOTO Yasuhisa , YOSHIKAWA Kazuhiko , SHIBA Masatsugu , FUKUDA Takashi , SOWA Michio Journal of gastroenterology 30(1), 103-107, 1995-02 医中誌Web 参考文献22件 被引用文献2件 ...
Samples used in this research were selected from the list of "Maximale Arbeitsplatz-Konzentration" (MAK) and "Biologischer Arbeitsstoff-Toleranz-Wert" (BAT) values 2008, Deutschen Forschungsge-meinschaft (DFG) for positive samples (skin sensitizers) and from the classification results of the Japanese Globally Harmonized System of Classification and Labeling of Chemicals (GHS) Inter-ministerial Committee of the National Institute for Technology and Evaluation for negative skin sensitizers (controls). A total of 291 compounds (122 positive sensitizers and 169 negative sensitizers) were used in this study. Parameters were generated from 2-D and 3-D structures of compounds. All of the approximately 800 parameters generated were reduced to 47 parameter sets and 32 parameter sets by feature selection. Vari-ous linear and non-linear discriminant analysis methods were applied using 2 parameter sets. All data analyses were performed using ADMEWORKS/ModelBuilder software ...
Video created by Icahn School of Medicine at Mount Sinai for the course Network Analysis in Systems Biology. This module is devoted to various method of clustering: principal component analysis, self-organizing maps, network-based clustering ...
Self-Organizing maps (SOM) have become quite popular for tasks in data visualization, pattern classification or natural language processing and can be seen as one of the major concepts for artificial neural networks of today. Their general idea is it to approximate a high dimensional previously unknown input distribution by a lower dimensional neural network structure with the goal to model the topology of the input space as good as possible. Classical Self-Organizing Maps read the input values in random but sequential order one by one and thus adjust the network structure over space: The network will be build while reading bigger and bigger parts of the input. In contrast to this approach, we present a Self-Organizing Map that processes the whole input in parallel and organizes itself over time. The main reason for parallel input processing lies in the fact that knowledge can be used to recognize parts of patterns in the input space that have already been learned. This way, networks can be ...
A new approach to analysis of protein-ligand interactions, termed proteochemometrics, has been developed. Contrary to traditional quantitative structure-activity relationship (QSAR) methods that aim to correlate a description of ligands to their interactions with one particular target protein, proteochemometrics considers many targets simultaneously.. Proteochemometrics thus analyzes the experimentally determined protein-ligand interaction activity data by correlating the data to a complex description of all interaction partners and; in a more general case even to interaction environment and assaying conditions, as well. In this way, a proteochemometric model analyzes an "interaction space," from which only one cross-section would be contemplated by any one QSAR model.. Proteochemometric models reveal the physicochemical and structural properties that are essential for protein-ligand complementarity and determine specificity of molecular interactions. From a drug design perspective, models may ...
The knowledge bases are, for example, OECD/NEAs Thermochemical Database (127, 128), solvent-extraction database and programs for analysis (129-132). Although methodologies of modeling, how to use the tools, depend heavily on the researchers expertise, requisite criteria for design is the knowledge about the relationship between ligand structure and the nature of metal-donor group interactions; -quantitative -structure-activity relationship (QSAR). Many investigations to establish methodologies for designing ligands possessing high affinity and selectivity to specified metal ions have appeared during the past decade (133-150). In the framework of the AFCI program, Peterman et al. of Idaho National Laboratory (INL) have examined the feasibility of using the Cyanex 301 system for treating an ammonium acetate/acetic acid buffered solution (308), which was used in the TRUEX process as a strip solution of Ans and Lns. 37 M TBP in n-dodecane was studied. At a region of specific pH value, the ...
The toxicological screening of the numerous chemicals that we are exposed to requires significant cost and the use of animals. Accordingly, more efficient methods for the evaluation of toxicity are required to reduce cost and the number of animals used. Computational strategies have the potential to reduce both the cost and the use of animal testing in toxicity screening. The ultimate goal of this thesis is to develop computational models for the prediction of toxicological endpoints that can serve as an alternative to animal testing. In Paper I, an attempt was made to construct a global quantitative structure-activity relationship (QSAR)model for the acute toxicity endpoint (LD50 values) using the Munro database that represents a broad chemical landscape. Such a model could be used for acute toxicity screening of chemicals of diverse structures. Paper II focuses on the use of acute toxicity data to support the prediction of chronic toxicity. The results of this study suggest that for related ...
What causes essential thrombocythemia? Learn more about this disease, and find information on support and resources at VoicesofMPN.com.
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Objectives The occupational hazard of chemical absorption via dermal route was frequently assessed by evaluating the skin permeability (Kp) of chemical. In addition to in vitro testing using human skin, the quantitative structure-activity relationship (QSAR) has been employed as an alternative source to providing Kp. In the early Kp QSARs the octanol-water partition coefficient (log KOW) and molecular weight (MW) were commonly applied as dominant properties to describe transdermal transport of chemical. This study examined the efficacy of log KOW-/MW-based QSARs in Kp prediction.. ...
Research outlines. The research projects cover the development and application of new experimental, in silico and cheminformatic algorithms to derive appropriate strategies for solving real problems in chemistry, namely in the field of quantitative structure-activity relationships (QSAR) applied in drug discovery and optimization, human metabolism, human toxicity, food and environmental chemistry. Curriculum vitae Prof. Gabriele CRUCIANI. Academic career. Gabriele Cruciani is full professor in Organic Chemistry since 2005 at the Chemistry Department of the University of Perugia (Italy). In 1994, when he still was a research assistant, he was the local recipient of the EU project BIO2-CT94-3025 relative to the design of new inhibitors of Glycogen phosphorilase b, leaded by the laboratory of molecular biophysics of the Oxford University.. From 1994 to 2009 he was responsible of the course "Modeling of organic molecules" for the last year students of the Master in Chemical Sciences (organic ...
We apply measures of complexity, emergence, and self-organization to an urban traffic model for comparing a traditional traffic-light coordination method with a self-organizing method in two scenarios: cyclic boundaries and non-orientable boundaries. We show that the measures are useful to identify and characterize different dynamical phases. It becomes clear that different operation regimes are required for different traffic demands. Thus, not only is traffic a non-stationary problem, requiring controllers to adapt constantly; controllers must also change drastically the complexity of their behavior depending on the demand. Based on our measures and extending Ashbys law of requisite variety, we can say that the self-organizing method achieves an adaptability level comparable to that of a living system.
Research done in Prof. Sharon Bickels lab has demonstrated that oxidative damage causes a premature loss of sister chromatid cohesion and an increase in chromosome segregation errors in Drosophila oocytes during meiosis. In women, the probability of miscarriage or Down Syndrome increases dramatically with age. Studies of maternal age effect indicate that errors in female meiosis contribute significantly to this age-related effect. The research done by the Bickel lab demonstrates that if oxidative damage contributes to maternal age effect then reducing oxidative damage could be a strategy for reducing chromosome segregation errors during meiosis.. Professor Sharon Bickel, MCB graduate student Adrienne Perkins, Class of 2013 undergraduate researcher Thomas Das and second year MCB graduate student Lauren Panzera contributed to this work. These findings were published in the Proceeding of the National Academy of Sciences: http://www.pnas.org/content/early/2016/10/12/1612047113.full ...

Frontiers in Bioscience 5, e153-171, November 1, 2000]Frontiers in Bioscience 5, e153-171, November 1, 2000]

4.3 Carbazilquinone 4.3.1 Preclinical Studies Carbazilquinone was first synthesized in 1970 as a mitomycin C analogue having a ... Carbazilquinone 4.3.1. Preclinical studies 4.3.2. Clinical studies. 4.4. Other benzoquinone-containing alkylating agents 4.4.1 ... Carbazilquinone has been extensively studied in the clinic, primarily in Japan, since the 1970s. Initial studies suggested that ... Carbazilquinone also produced a 60% response rate when used with doxorubicin and bleomycin in patients with superficial bladder ...
more infohttp://www.bioscience.org/2000/v5/e/begleit/fulltext.htm

Plus itPlus it

Komiyama T., Kikuchi T., Sugiura Y. Generation of hydroxyl radical by anticancer quinone drugs, carbazilquinone, mitomycin C, ...
more infohttp://cancerres.aacrjournals.org/content/63/20/6914

List of MeSH codes (D03) - WikipediaList of MeSH codes (D03) - Wikipedia

... carbazilquinone MeSH D03.383.097.217.900 --- triaziquone MeSH D03.383.097.217.924 --- triethylenemelamine MeSH D03.383.097.217. ...
more infohttps://en.wikipedia.org/wiki/List_of_MeSH_codes_(D03)

List of MeSH codes (D02) - WikipediaList of MeSH codes (D02) - Wikipedia

... carbazilquinone MeSH D02.806.250.210 --- chloranil MeSH D02.806.250.280 --- dibromothymoquinone MeSH D02.806.250.700 --- ...
more infohttps://en.wikipedia.org/wiki/List_of_MeSH_codes_(D02)

研究成果の検索
             - 九州大学研究成果の検索 - 九州大学

Ichinose, M., Miki, K., Tatematsu, M., Mizuno, T., Mutai, M., Furihata, C., Ichihara, Y., Ishihara, T., Tanji, M., Oka, H., Hinohara, Y., Takahashi, T., Kageyama, T. & Takahashi, K., 9 15 1988, : : Biochemical and Biophysical Research Communications. 155, 2, p. 670-677 8 p.. 研究成果: ジャーナルへの寄稿 › 記事 ...
more infohttps://kyushu-u.pure.elsevier.com/ja/publications/?format=&%3Bpage=4&ordering=publicationYearThenTitle&descending=true&page=2413

Find Research Outputs
             - Kyushu UniversityFind Research Outputs - Kyushu University

Murakami, K., Mori, S. I., Fukuda, A., Sueyoshi, T. & Tomita, S., Jun 1 1989, Proceedings of the 3rd International Conference on Supercomputing, ICS 1989. Association for Computing Machinery, p. 351-360 10 p. (Proceedings of the International Conference on Supercomputing; vol. Part F130180).. Research output: Chapter in Book/Report/Conference proceeding › Conference contribution ...
more infohttps://kyushu-u.pure.elsevier.com/en/publications/?format=&%3Bpage=1&page=2335

Subject Strain Bibliography 1970 | Subject Strain Bibliography records from the 1970s | The Jackson LaboratorySubject Strain Bibliography 1970 | Subject Strain Bibliography records from the 1970s | The Jackson Laboratory

Effect of carbazilquinone on transplantable and primary tumors in mice., M Arakawa, H Nakao, and T Aoki ... Effect of carbazilquinone on lymphoid leukemia l-1210., M Arakawa, T Aoki, and H Nakao ...
more infohttp://mouseion.jax.org/ssbb1970/

ImmunotherapyImmunotherapy

Alternating immunotherapy of advanced gastric carcinoma: A randomized comparison of carbazilquinone and PSK to carbazilquinone ... or carbazilquinone alone. Each course of therapies started 1 week after the surgical operation and therapy schedules consisted ...
more infohttp://mushroomstudies.co/category/why-it-works/immunotherapy/page/4/

Coriolus MushroomCoriolus Mushroom

... a randomized comparison of carbazilquinone and PSK to carbazilquinone in patients with curative gastric resection. Biotherapy ...
more infohttps://gigasnutrition.com/de/Inhaltsstoffe/Coriolus-mushroom

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