The largest class of organic compounds, including STARCH; GLYCOGEN; CELLULOSE; POLYSACCHARIDES; and simple MONOSACCHARIDES. Carbohydrates are composed of carbon, hydrogen, and oxygen in a ratio of Cn(H2O)n.
Allied Health Occupations
Cellular processes in biosynthesis (anabolism) and degradation (catabolism) of CARBOHYDRATES.
Carbohydrates present in food comprising digestible sugars and starches and indigestible cellulose and other dietary fibers. The former are the major source of energy. The sugars are in beet and cane sugar, fruits, honey, sweet corn, corn syrup, milk and milk products, etc.; the starches are in cereal grains, legumes (FABACEAE), tubers, etc. (From Claudio & Lagua, Nutrition and Diet Therapy Dictionary, 3d ed, p32, p277)
Library Collection Development
Development of a library collection, including the determination and coordination of selection policy, assessment of needs of users and potential users, collection use studies, collection evaluation, identification of collection needs, selection of materials, planning for resource sharing, collection maintenance and weeding, and budgeting.
Textbooks as Topic
The segregation and degradation of damaged or unwanted cytoplasmic constituents by autophagic vacuoles (cytolysosomes) composed of LYSOSOMES containing cellular components in the process of digestion; it plays an important role in BIOLOGICAL METAMORPHOSIS of amphibians, in the removal of bone by osteoclasts, and in the degradation of normal cell components in nutritional deficiency states.
A glycoside obtained from Digitalis purpurea; the aglycone is digitogenin which is bound to five sugars. Digitonin solubilizes lipids, especially in membranes and is used as a tool in cellular biochemistry, and reagent for precipitating cholesterol. It has no cardiac effects.
Biological Science Disciplines
All of the divisions of the natural sciences dealing with the various aspects of the phenomena of life and vital processes. The concept includes anatomy and physiology, biochemistry and biophysics, and the biology of animals, plants, and microorganisms. It should be differentiated from BIOLOGY, one of its subdivisions, concerned specifically with the origin and life processes of living organisms.
Home Care Services
Community health and NURSING SERVICES providing coordinated multiple services to the patient at the patient's homes. These home-care services are provided by a visiting nurse, home health agencies, HOSPITALS, or organized community groups using professional staff for care delivery. It differs from HOME NURSING which is provided by non-professionals.
Homes for the Aged
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Seedless nonflowering plants of the class Filicinae. They reproduce by spores that appear as dots on the underside of feathery fronds. In earlier classifications the Pteridophyta included the club mosses, horsetails, ferns, and various fossil groups. In more recent classifications, pteridophytes and spermatophytes (seed-bearing plants) are classified in the Subkingdom Tracheobionta (also known as Tracheophyta).
Critical and exhaustive investigation or experimentation, having for its aim the discovery of new facts and their correct interpretation, the revision of accepted conclusions, theories, or laws in the light of newly discovered facts, or the practical application of such new or revised conclusions, theories, or laws. (Webster, 3d ed)
"The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.
National Academy of Sciences (U.S.)
A United States organization of distinguished scientists and engineers established for the purpose of investigating and reporting upon any subject of art or science as requested by any department of government. The National Research Council organized by NAS serves as the principal operating agency to stimulate and support research.
Former kingdom, located on Korea Peninsula between Sea of Japan and Yellow Sea on east coast of Asia. In 1948, the kingdom ceased and two independent countries were formed, divided by the 38th parallel.
Academies and Institutes
Organizations representing specialized fields which are accepted as authoritative; may be non-governmental, university or an independent research organization, e.g., National Academy of Sciences, Brookings Institution, etc.
Nucleotidylation of unsaturated carbasugar in validamycin biosynthesis. (1/1)(+info)
In this thesis the synthesis of several hydrolytically stable carbohydrate mimics with the potential to function as glycosidase or lectin inhibitors are described. This work is presented in Chapters 2-5.. Chapters 2 and 3 describe synthetic efforts for producing carbasugars, and include the first synthesis of 1,2-bis-epi-valienamine and the preparation of two previously known aminocarbasugars. All three compounds were synthesised starting from D-mannose, using ring-closing metathesis as the key step. 1,2-Bis-epi-valienamine was found to inhibit Cellulomonas fimi β-mannosidase with a Ki value of 140 mM. Also included is the development of a novel synthetic route from cheap D-fructose to three mannose-mimicking carbasugars using a ring-closing metathesis strategy. Two of the compounds are potential inhibitors of the FimH adhesin.. In Chapters 4 and 5 the synthesis of a number of pseudodisaccharides are presented; valienamine- and epi-valienamine-containing pseudodisaccharides and a small library ...
Genomic and transcriptomic insights into the thermo-regulated biosynthesis of validamycin in Streptomyces hygroscopicus 5008 |...
Streptomyces hygroscopicus 5008 has been used for the production of the antifungal validamycin/jinggangmycin for more than 40 years. A high yield of validamycin is achieved by culturing the strain at 37°C, rather than at 30°C for normal growth and sporulation. The mechanism(s) of its thermo-regulated biosynthesis was largely unknown. The 10,383,684-bp genome of strain 5008 was completely sequenced and composed of a linear chromosome, a 164.57-kb linear plasmid, and a 73.28-kb circular plasmid. Compared with other Streptomyces genomes, the chromosome of strain 5008 has a smaller core region and shorter terminal inverted repeats, encodes more α/β hydrolases, major facilitator superfamily transporters, and Mg2+/Mn2+-dependent regulatory phosphatases. Transcriptomic analysis revealed that the expression of 7.5% of coding sequences was increased at 37°C, including biosynthetic genes for validamycin and other three secondary metabolites. At 37°C, a glutamate dehydrogenase was transcriptionally up
RCSB PDB - 3VDN: Crystal Structure of VldE, the pseudo-glycosyltransferase, in complex with GDP Macromolecule...
3VDN: Crystal Structure of the VldE, the pseudo-glycosyltransferase, which catalyzes non-glycosidic C-N coupling in Validamycin A biosynthesis
Petr Sedmera; Petr Halada & Stanislav Pospisil (2009). "New carbasugars from Streptomyces lincolnensis". Mag. Reson. Chem. 47: ...
C-5a unsaturated carbasugars with lyxo configuration.. Place, publisher, year, edition, pages Elsevier Ltd., 2009 National ... Also included is the development of a novel synthetic route from cheap D-fructose to three mannose-mimicking carbasugars using ... Chapters 2 and 3 describe synthetic efforts for producing carbasugars, and include the first synthesis of 1,2-bis-epi- ...
Structural snapshots for mechanism-based inactivation of a glycoside hydrolase by cyclopropyl-carbasugars - University...
Structural snapshots for mechanism-based inactivation of a glycoside hydrolase by cyclopropyl-carbasugars. Research output: ...
Valienol - Wikipedia
Pandey P[au] - PubMed - NCBI
Advances in Carbohydrate Chemistry and Biochemistry, Volume 59 - 1st Edition
Advances in Carbohydrate Chemistry and Biochemistry, Volume 48 - 1st Edition
Molecular Basis for Trehalase Inhibition Revealed by the Structure of Trehalase in Complex with Potent Inhibitors - Gibson -...
Bioactive Carbohydrates and Recently Discovered Analogues as Chemotherapeutics | Bentham Science
Thio-[beta]-D-glucosides: synthesis and evaluation as glycosidase inhibitors and activators. - Free Online Library
Home - Biosynth Direct Store
Carbasugars and substituted cyclopentanes are now available at Biosynth for your research or manufacturing needs. ...
Thus, imino sugars (1), isoimino sugars (2) and amine substituted carbasugars (3) may be distinguished as the main scaffolds. ... Amongst the various types of inhibitors, low molecular weight iminosugars, carbasugars and certain types of highly ... we are currently exploring isoimino sugars as well as selected carba sugars both of which allow for structural modifications ...
Kudos - helping increase the reach and impact of research
Synthesis of Spiro Carba-Sugars by Ring-Closing Metathesis. Published in:European Journal of Organic Chemistry. Publication ... Synthesis of Amino Carba Sugars and Conformationally Restricted Polyhydroxyγ-Amino Acids from (−)-Quinic Acid. Published in: ... Synthesis of carba-sugars from (−)-quinic acid. Published in:Tetrahedron Letters. Publication date:2001-06-01 ... ChemInform Abstract: Synthesis of Carba-Sugars from (-)-Quinic Acid.. Published in:ChemInform. Publication date:2010-05-24 ...
Divergent Reactions for Racemates Catalytic Enantioselective and Regiodivergent Nitroso DielsЦAlder Reactions.
Received: April 13, 2007 Published online: July 25, 2007 . Keywords: asymmetric catalysis · carbasugars · copper · ... which belongs to the class of pseudosugars or carbasugars with interesting biological activity. To this end the N O bond in ... and the products obtained are valuable compounds for the synthesis of biologically interesting carbasugars. We believe that ...
Find Research Projects - Graz University of Technology
Carbasugars. Griengl, H.. 1/01/95 → 31/01/98. Project: Research project ...
Department of Biosciences and Informatics - Research Output - Keio University
Takai, T., Higaki, K., Aguilar-Moncayo, M., Mena-Barragán, T., Hirano, Y., Yura, K., Yu, L., Ninomiya, H., García-Moreno, M. I., Sakakibara, Y., Ohno, K., Nanba, E., Ortiz Mellet, C., García Fernández, J. M. & Suzuki, Y., 2013 Mar, In : Molecular Therapy. 21, 3, p. 526-532 7 p.. Research output: Contribution to journal › Article ...
Find Research Outputs - Graz University of Technology
Jin Won Cho - Research Output - Yonsei University
Kima, E., Kima, E., Kang, J. G., Kang, M. J., Park, J. H., Kim, Y. J., Kim, Y. J., Kweon, T. H., Kweon, T. H., Lee, H. W., Jho, E. H., Jho, E. H., Lee, Y. H., Lee, Y. H., Kim, S. I., Yi, E. C., Yi, E. C., Park, H. W., Yang, W. H., Yang, W. H. & 3 others, Cho, J. W., Cho, J. W. & Cho, J. W., 2020 Jun 23, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 25, p. 14259-14269 11 p.. Research output: Contribution to journal › Article ...
生命情報学科 - 研究成果 - Keio University
Aguilar-Moncayo, M., Takai, T., Higaki, K., Mena-Barragán, T., Hirano, Y., Yura, K., Li, L., Yu, Y., Ninomiya, H., García-Moreno, M. I., Ishii, S., Sakakibara, Y., Ohno, K., Nanba, E., Ortiz Mellet, C., García Fernández, J. M. & Suzuki, Y., 2012 6 6, ： : Chemical Communications. 48, 52, p. 6514-6516 3 p.. 研究成果: Article ...
Synthesis of a conformationally locked version of puromycin amino nucleoside<...
TY - JOUR. T1 - Synthesis of a conformationally locked version of puromycin amino nucleoside. AU - Choi, Yongseok. AU - George, Clifford. AU - Strazewski, Peter. AU - Marquez, Victor E.. PY - 2002/2/21. Y1 - 2002/2/21. N2 - (formula presented) A conformationally locked carbocyclic version of puromycin amino nucleoside was synthesized via Mitsunobu coupling of a 3-azido-substituted carbocyclic moiety with 6-chloropurine without interference from the azido group reacting with triphenylphosphine. The requisite 3-azido-substituted carbocyclic pseudosugar was prepared by a double inversion of configuration at C3′ (nucleoside numbering) involving a nucleophilic displacement with azide.. AB - (formula presented) A conformationally locked carbocyclic version of puromycin amino nucleoside was synthesized via Mitsunobu coupling of a 3-azido-substituted carbocyclic moiety with 6-chloropurine without interference from the azido group reacting with triphenylphosphine. The requisite 3-azido-substituted ...
Non-glycosidically linked pseudodisaccharides : thioethers, sulfoxides, sulfones, ethers, selenoethers, and their binding to...
School of Biology | University of St Andrews
Full Publication List - Concepcion Gonzalez Bello Web Page
Synthesis of Spiro Carba-sugars by Ring-Closing Metathesis. C. González-Bello*, L. Castedo and F. J. Cañada. Eur. J. Org. Chem. ... Synthesis of Carba-sugars from (-)-Quinic Acid. M. Carballido, L. Castedo and C. González-Bello*. Tetrahedron Letters 2001, 42 ... Synthesis of Amino Carba-sugars and Conformationally Restricted Polyhydroxy-gamma-amino Acids from (−)-Quinic Acid. M. ...
IXb - Mayer/Möglich: Organization of SPP 1926
Institut Parisien de Chimie Moléculaire - Publications
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- Chapters 2 and 3 describe synthetic efforts for producing carbasugars, and include the first synthesis of 1,2-bis- epi -valienamine and the preparation of two previously known aminocarbasugars. (diva-portal.org)
- Synthesis of alpha- and beta-galactose, alpha-talose and alpha-fucopyranose carbasugars. (iisc.ernet.in)
- Amongst the various types of inhibitors, low molecular weight iminosugars, carbasugars and certain types of highly functionalised, water-soluble bicyclic alkaloids have frequently been exploited. (tugraz.at)