Sugar analogs in which the ring oxygen is replaced by a methylene CH2 carbon.
The largest class of organic compounds, including STARCH; GLYCOGEN; CELLULOSE; POLYSACCHARIDES; and simple MONOSACCHARIDES. Carbohydrates are composed of carbon, hydrogen, and oxygen in a ratio of Cn(H2O)n.
Occupations of medical personnel who are not physicians, and are qualified by special training and, frequently, by licensure to work in supporting roles in the health care field. These occupations include, but are not limited to, medical technology, physical therapy, physician assistant, etc.
Cellular processes in biosynthesis (anabolism) and degradation (catabolism) of CARBOHYDRATES.
Carbohydrates present in food comprising digestible sugars and starches and indigestible cellulose and other dietary fibers. The former are the major source of energy. The sugars are in beet and cane sugar, fruits, honey, sweet corn, corn syrup, milk and milk products, etc.; the starches are in cereal grains, legumes (FABACEAE), tubers, etc. (From Claudio & Lagua, Nutrition and Diet Therapy Dictionary, 3d ed, p32, p277)
Development of a library collection, including the determination and coordination of selection policy, assessment of needs of users and potential users, collection use studies, collection evaluation, identification of collection needs, selection of materials, planning for resource sharing, collection maintenance and weeding, and budgeting.
Books used in the study of a subject that contain a systematic presentation of the principles and vocabulary of a subject.
An enzyme that catalyzes the conversion of alpha,alpha-trehalose and water to D-glucose. EC 3.2.1.28.
A disaccharide consisting of one galactose and one glucose moiety in an alpha (1-6) glycosidic linkage.
A synthetic disaccharide used in the treatment of constipation and hepatic encephalopathy. It has also been used in the diagnosis of gastrointestinal disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p887)
The segregation and degradation of damaged or unwanted cytoplasmic constituents by autophagic vacuoles (cytolysosomes) composed of LYSOSOMES containing cellular components in the process of digestion; it plays an important role in BIOLOGICAL METAMORPHOSIS of amphibians, in the removal of bone by osteoclasts, and in the degradation of normal cell components in nutritional deficiency states.
Oligosaccharides containing two monosaccharide units linked by a glycosidic bond.
The geographical area of Africa comprising ANGOLA; BOTSWANA; LESOTHO; MALAWI; MOZAMBIQUE; NAMIBIA; SOUTH AFRICA; SWAZILAND; ZAMBIA; and ZIMBABWE.
Neurologic disorders caused by exposure to toxic substances through ingestion, injection, cutaneous application, or other method. This includes conditions caused by biologic, chemical, and pharmaceutical agents.
Sequential operating programs and data which instruct the functioning of a digital computer.
A glycoside obtained from Digitalis purpurea; the aglycone is digitogenin which is bound to five sugars. Digitonin solubilizes lipids, especially in membranes and is used as a tool in cellular biochemistry, and reagent for precipitating cholesterol. It has no cardiac effects.
That segment of commercial enterprise devoted to the design, development, and manufacture of chemical products for use in the diagnosis and treatment of disease, disability, or other dysfunction, or to improve function.
All of the divisions of the natural sciences dealing with the various aspects of the phenomena of life and vital processes. The concept includes anatomy and physiology, biochemistry and biophysics, and the biology of animals, plants, and microorganisms. It should be differentiated from BIOLOGY, one of its subdivisions, concerned specifically with the origin and life processes of living organisms.
Exclusive legal rights or privileges applied to inventions, plants, etc.
Agents that emit light after excitation by light. The wave length of the emitted light is usually longer than that of the incident light. Fluorochromes are substances that cause fluorescence in other substances, i.e., dyes used to mark or label other compounds with fluorescent tags.
The study of microorganisms such as fungi, bacteria, algae, archaea, and viruses.
Facilities which provide nursing supervision and limited medical care to persons who do not require hospitalization.
A characteristic feature of enzyme activity in relation to the kind of substrate on which the enzyme or catalytic molecule reacts.
Community health and NURSING SERVICES providing coordinated multiple services to the patient at the patient's homes. These home-care services are provided by a visiting nurse, home health agencies, HOSPITALS, or organized community groups using professional staff for care delivery. It differs from HOME NURSING which is provided by non-professionals.
Geriatric long-term care facilities which provide supervision and assistance in activities of daily living with medical and nursing services when required.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
The rate dynamics in chemical or physical systems.
Generating tissue in vitro for clinical applications, such as replacing wounded tissues or impaired organs. The use of TISSUE SCAFFOLDING enables the generation of complex multi-layered tissues and tissue structures.
A genus of aerobic or facultatively anaerobic BACTERIA, in the family Cellulomonadaceae. It is found in the SOIL and capable of hydrolyzing CELLULOSE.
Changing an open-chain hydrocarbon to a closed ring. (McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
Unsaturated hydrocarbons of the type Cn-H2n, indicated by the suffix -ene. (Grant & Hackh's Chemical Dictionary, 5th ed, p408)
A hard, brittle, grayish-white rare earth metal with an atomic symbol Ru, atomic number 44, and atomic weight 101.07. It is used as a catalyst and hardener for PLATINUM and PALLADIUM.
The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.
The use of statistical methods in the analysis of a body of literature to reveal the historical development of subject fields and patterns of authorship, publication, and use. Formerly called statistical bibliography. (from The ALA Glossary of Library and Information Science, 1983)
The field of information science concerned with the analysis and dissemination of medical data through the application of computers to various aspects of health care and medicine.
The field of information science concerned with the analysis and dissemination of data through the application of computers applied to the field of nursing.
Copies of a work or document distributed to the public by sale, rental, lease, or lending. (From ALA Glossary of Library and Information Science, 1983, p181)
Seedless nonflowering plants of the class Filicinae. They reproduce by spores that appear as dots on the underside of feathery fronds. In earlier classifications the Pteridophyta included the club mosses, horsetails, ferns, and various fossil groups. In more recent classifications, pteridophytes and spermatophytes (seed-bearing plants) are classified in the Subkingdom Tracheobionta (also known as Tracheophyta).
Critical and exhaustive investigation or experimentation, having for its aim the discovery of new facts and their correct interpretation, the revision of accepted conclusions, theories, or laws in the light of newly discovered facts, or the practical application of such new or revised conclusions, theories, or laws. (Webster, 3d ed)
"The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.
A United States organization of distinguished scientists and engineers established for the purpose of investigating and reporting upon any subject of art or science as requested by any department of government. The National Research Council organized by NAS serves as the principal operating agency to stimulate and support research.
Former kingdom, located on Korea Peninsula between Sea of Japan and Yellow Sea on east coast of Asia. In 1948, the kingdom ceased and two independent countries were formed, divided by the 38th parallel.
Organizations representing specialized fields which are accepted as authoritative; may be non-governmental, university or an independent research organization, e.g., National Academy of Sciences, Brookings Institution, etc.

Nucleotidylation of unsaturated carbasugar in validamycin biosynthesis. (1/1)

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In this thesis the synthesis of several hydrolytically stable carbohydrate mimics with the potential to function as glycosidase or lectin inhibitors are described. This work is presented in Chapters 2-5.. Chapters 2 and 3 describe synthetic efforts for producing carbasugars, and include the first synthesis of 1,2-bis-epi-valienamine and the preparation of two previously known aminocarbasugars. All three compounds were synthesised starting from D-mannose, using ring-closing metathesis as the key step. 1,2-Bis-epi-valienamine was found to inhibit Cellulomonas fimi β-mannosidase with a Ki value of 140 mM. Also included is the development of a novel synthetic route from cheap D-fructose to three mannose-mimicking carbasugars using a ring-closing metathesis strategy. Two of the compounds are potential inhibitors of the FimH adhesin.. In Chapters 4 and 5 the synthesis of a number of pseudodisaccharides are presented; valienamine- and epi-valienamine-containing pseudodisaccharides and a small library ...
Streptomyces hygroscopicus 5008 has been used for the production of the antifungal validamycin/jinggangmycin for more than 40 years. A high yield of validamycin is achieved by culturing the strain at 37°C, rather than at 30°C for normal growth and sporulation. The mechanism(s) of its thermo-regulated biosynthesis was largely unknown. The 10,383,684-bp genome of strain 5008 was completely sequenced and composed of a linear chromosome, a 164.57-kb linear plasmid, and a 73.28-kb circular plasmid. Compared with other Streptomyces genomes, the chromosome of strain 5008 has a smaller core region and shorter terminal inverted repeats, encodes more α/β hydrolases, major facilitator superfamily transporters, and Mg2+/Mn2+-dependent regulatory phosphatases. Transcriptomic analysis revealed that the expression of 7.5% of coding sequences was increased at 37°C, including biosynthetic genes for validamycin and other three secondary metabolites. At 37°C, a glutamate dehydrogenase was transcriptionally up
3VDN: Crystal Structure of the VldE, the pseudo-glycosyltransferase, which catalyzes non-glycosidic C-N coupling in Validamycin A biosynthesis
Petr Sedmera; Petr Halada & Stanislav Pospisil (2009). "New carbasugars from Streptomyces lincolnensis". Mag. Reson. Chem. 47: ...
C-5a unsaturated carbasugars with lyxo configuration.. Place, publisher, year, edition, pages Elsevier Ltd., 2009 National ... Also included is the development of a novel synthetic route from cheap D-fructose to three mannose-mimicking carbasugars using ... Chapters 2 and 3 describe synthetic efforts for producing carbasugars, and include the first synthesis of 1,2-bis-epi- ...
Structural snapshots for mechanism-based inactivation of a glycoside hydrolase by cyclopropyl-carbasugars. Research output: ...
Petr Sedmera; Petr Halada & Stanislav Pospisil (2009). "New carbasugars from Streptomyces lincolnensis". Mag. Reson. Chem. 47: ...
Antileishmanial Carbasugars from Geosmithia langdonii.. Malak LG, Ibrahim MA, Moharram AM, Pandey P, Tekwani B, Doerksen RJ, ...
5. Hydrazine derivatives of carba sugars and related compounds. Description. Since its inception in 1945, Advances in ...
T. Suami and S. Ogawa, Carba-Sugars Chemistry of (Pseudo-Sugars) and Their Derivatives. ...
Silvia Roscales, Joaquín Plumet, Biosynthesis and Biological Activity of Carbasugars, International Journal of Carbohydrate ...
Chemical Intermediates and Tools for Organic SynthesisAminoethylphosphonic acid, Ala(P) Carbasugars Chiral Epoxides ...
Keywords:carbohydrates, nucleosides, carbasugars, antibiotics, glycopeptide conjugates, chemotherapeutics. Abstract: Infectious ...
From vinyl pyranoses to carbasugars by an iron-catalyzed reaction complementary to classical Ferrier carbocyclisation. Chemical ...
... carbasugars, and some other inhibitors. It was explained by additional stabilization of the alkyl chains or aromatic residues ...
Carbasugars and substituted cyclopentanes are now available at Biosynth for your research or manufacturing needs. ...
Thus, imino sugars (1), isoimino sugars (2) and amine substituted carbasugars (3) may be distinguished as the main scaffolds. ... Amongst the various types of inhibitors, low molecular weight iminosugars, carbasugars and certain types of highly ... we are currently exploring isoimino sugars as well as selected carba sugars both of which allow for structural modifications ...
Synthesis of Spiro Carba-Sugars by Ring-Closing Metathesis. Published in:European Journal of Organic Chemistry. Publication ... Synthesis of Amino Carba Sugars and Conformationally Restricted Polyhydroxyγ-Amino Acids from (−)-Quinic Acid. Published in: ... Synthesis of carba-sugars from (−)-quinic acid. Published in:Tetrahedron Letters. Publication date:2001-06-01 ... ChemInform Abstract: Synthesis of Carba-Sugars from (-)-Quinic Acid.. Published in:ChemInform. Publication date:2010-05-24 ...
Received: April 13, 2007 Published online: July 25, 2007 . Keywords: asymmetric catalysis · carbasugars · copper · ... which belongs to the class of pseudosugars or carbasugars with interesting biological activity.[10] To this end the N O bond in ... and the products obtained are valuable compounds for the synthesis of biologically interesting carbasugars. We believe that ...
Takai, T., Higaki, K., Aguilar-Moncayo, M., Mena-Barragán, T., Hirano, Y., Yura, K., Yu, L., Ninomiya, H., García-Moreno, M. I., Sakakibara, Y., Ohno, K., Nanba, E., Ortiz Mellet, C., García Fernández, J. M. & Suzuki, Y., 2013 Mar, In : Molecular Therapy. 21, 3, p. 526-532 7 p.. Research output: Contribution to journal › Article ...
... provides an overview of common techniques for the synthesis of carbasugars and C-glycosides, reviews the syntheses published to ...
Kima, E., Kima, E., Kang, J. G., Kang, M. J., Park, J. H., Kim, Y. J., Kim, Y. J., Kweon, T. H., Kweon, T. H., Lee, H. W., Jho, E. H., Jho, E. H., Lee, Y. H., Lee, Y. H., Kim, S. I., Yi, E. C., Yi, E. C., Park, H. W., Yang, W. H., Yang, W. H. & 3 others, Cho, J. W., Cho, J. W. & Cho, J. W., 2020 Jun 23, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 25, p. 14259-14269 11 p.. Research output: Contribution to journal › Article ...
Aguilar-Moncayo, M., Takai, T., Higaki, K., Mena-Barragán, T., Hirano, Y., Yura, K., Li, L., Yu, Y., Ninomiya, H., García-Moreno, M. I., Ishii, S., Sakakibara, Y., Ohno, K., Nanba, E., Ortiz Mellet, C., García Fernández, J. M. & Suzuki, Y., 2012 6 6, : : Chemical Communications. 48, 52, p. 6514-6516 3 p.. 研究成果: Article ...
TY - JOUR. T1 - Synthesis of a conformationally locked version of puromycin amino nucleoside. AU - Choi, Yongseok. AU - George, Clifford. AU - Strazewski, Peter. AU - Marquez, Victor E.. PY - 2002/2/21. Y1 - 2002/2/21. N2 - (formula presented) A conformationally locked carbocyclic version of puromycin amino nucleoside was synthesized via Mitsunobu coupling of a 3-azido-substituted carbocyclic moiety with 6-chloropurine without interference from the azido group reacting with triphenylphosphine. The requisite 3-azido-substituted carbocyclic pseudosugar was prepared by a double inversion of configuration at C3′ (nucleoside numbering) involving a nucleophilic displacement with azide.. AB - (formula presented) A conformationally locked carbocyclic version of puromycin amino nucleoside was synthesized via Mitsunobu coupling of a 3-azido-substituted carbocyclic moiety with 6-chloropurine without interference from the azido group reacting with triphenylphosphine. The requisite 3-azido-substituted ...
Also included is the development of a novel synthetic route from cheap D-fructose to three mannose-mimicking carbasugars using ... Chapters 2 and 3 describe synthetic efforts for producing carbasugars, and include the first synthesis of 1,2-bis-epi- ...
... hydrolase by cyclopropyl-carbasugars Angewandte Chemie International Edition, vol 55, no. 48, pp. 14978-14982. DOI: 10.1002/ ...
Synthesis of Spiro Carba-sugars by Ring-Closing Metathesis. C. González-Bello*, L. Castedo and F. J. Cañada. Eur. J. Org. Chem. ... Synthesis of Carba-sugars from (-)-Quinic Acid. M. Carballido, L. Castedo and C. González-Bello*. Tetrahedron Letters 2001, 42 ... Synthesis of Amino Carba-sugars and Conformationally Restricted Polyhydroxy-gamma-amino Acids from (−)-Quinic Acid. M. ...
Carba-sugars activate the glmS-riboswitch from Staphylococcus aureus. Lu?nse C.E., Schmidt M., Wittmann V., und Mayer G. ACS ...
Mots-clés : carbasugars, conformational equilibrium, fluorine, GOBS, L-idose, NMR spectroscopy, POLE 3. ...
Synthesis of alpha- and beta-galactose, alpha-talose and alpha-fucopyranose carbasugars. In: Tetrahedron Letters, 41 (18). pp. ...
  • Chapters 2 and 3 describe synthetic efforts for producing carbasugars, and include the first synthesis of 1,2-bis- epi -valienamine and the preparation of two previously known aminocarbasugars. (diva-portal.org)
  • Synthesis of alpha- and beta-galactose, alpha-talose and alpha-fucopyranose carbasugars. (iisc.ernet.in)
  • Amongst the various types of inhibitors, low molecular weight iminosugars, carbasugars and certain types of highly functionalised, water-soluble bicyclic alkaloids have frequently been exploited. (tugraz.at)
  • Carbasugars and substituted cyclopentanes are now available at Biosynth for your research or manufacturing needs. (biosynth.com)