The monoanhydride of carbamic acid with PHOSPHORIC ACID. It is an important intermediate metabolite and is synthesized enzymatically by CARBAMYL-PHOSPHATE SYNTHASE (AMMONIA) and CARBAMOYL-PHOSPHATE SYNTHASE (GLUTAMINE-HYDROLYZING).
An enzyme that catalyzes the formation of carbamoyl phosphate from ATP, carbon dioxide, and ammonia. This enzyme is specific for arginine biosynthesis or the urea cycle. Absence or lack of this enzyme may cause CARBAMOYL-PHOSPHATE SYNTHASE I DEFICIENCY DISEASE. EC 6.3.4.16.
A non-essential amino acid present abundantly throughout the body and is involved in many metabolic processes. It is synthesized from GLUTAMIC ACID and AMMONIA. It is the principal carrier of NITROGEN in the body and is an important energy source for many cells.
An enzyme that catalyzes the formation of carbamoyl phosphate from ATP, carbon dioxide, and glutamine. This enzyme is important in the de novo biosynthesis of pyrimidines. EC 6.3.5.5.
An enzyme that catalyzes the formation of myo-inositol-1-phosphate from glucose-6-phosphate in the presence of NAD. EC 5.5.1.4.
A urea cycle enzyme that catalyzes the formation of orthophosphate and L-citrulline (CITRULLINE) from CARBAMOYL PHOSPHATE and L-ornithine (ORNITHINE). Deficiency of this enzyme may be transmitted as an X-linked trait. EC 2.1.3.3.
An enzyme of the shikimate pathway of AROMATIC AMINO ACID biosynthesis, it generates 5-enolpyruvylshikimate 3-phosphate and ORTHOPHOSPHATE from PHOSPHOENOLPYRUVATE and shikimate-3-phosphate. The shikimate pathway is present in BACTERIA and PLANTS but not in MAMMALS.
An enzyme that catalyzes the formation of 7-phospho-2-keto-3-deoxy-D-arabinoheptonate from phosphoenolpyruvate and D-erythrose-4-phosphate. It is one of the first enzymes in the biosynthesis of TYROSINE and PHENYLALANINE. This enzyme was formerly listed as EC 4.1.2.15.
An enzyme that catalyzes the conversion of carbamoyl phosphate and L-aspartate to yield orthophosphate and N-carbamoyl-L-aspartate. (From Enzyme Nomenclature, 1992) EC 2.1.3.2.
Derivatives of carbamic acid, H2NC(=O)OH. Included under this heading are N-substituted and O-substituted carbamic acids. In general carbamate esters are referred to as urethanes, and polymers that include repeating units of carbamate are referred to as POLYURETHANES. Note however that polyurethanes are derived from the polymerization of ISOCYANATES and the singular term URETHANE refers to the ethyl ester of carbamic acid.
Inorganic salts of phosphoric acid.
An amino acid produced in the urea cycle by the splitting off of urea from arginine.
Enzymes that catalyze a reverse aldol condensation. A molecule containing a hydroxyl group and a carbonyl group is cleaved at a C-C bond to produce two smaller molecules (ALDEHYDES or KETONES). EC 4.1.2.
A class of enzymes that transfers phosphate groups and has a carboxyl group as an acceptor. EC 2.7.2.
A colorless alkaline gas. It is formed in the body during decomposition of organic materials during a large number of metabolically important reactions. Note that the aqueous form of ammonia is referred to as AMMONIUM HYDROXIDE.
An enzyme that catalyzes the synthesis of fructose-6-phosphate plus GLUTAMINE from GLUTAMATE plus glucosamine-6-phosphate.
Transferases are enzymes transferring a group, for example, the methyl group or a glycosyl group, from one compound (generally regarded as donor) to another compound (generally regarded as acceptor). The classification is based on the scheme "donor:acceptor group transferase". (Enzyme Nomenclature, 1992) EC 2.
Enzymes that catalyze the joining of two molecules by the formation of a carbon-nitrogen bond. EC 6.3.
An enzyme that catalyzes the conversion of ATP, L-glutamate, and NH3 to ADP, orthophosphate, and L-glutamine. It also acts more slowly on 4-methylene-L-glutamate. (From Enzyme Nomenclature, 1992) EC 6.3.1.2.
An enzyme in the tryptophan biosynthetic pathway. EC 4.1.1.48.
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.
The rate dynamics in chemical or physical systems.
A triazine nucleoside used as an antineoplastic antimetabolite. It interferes with pyrimidine biosynthesis thereby preventing formation of cellular nucleic acids. As the triacetate, it is also effective as an antipsoriatic.
A somewhat heterogeneous class of enzymes that catalyze the transfer of alkyl or related groups (excluding methyl groups). EC 2.5.
Enzymes that catalyze the transfer of glucose from a nucleoside diphosphate glucose to an acceptor molecule which is frequently another carbohydrate. EC 2.4.1.-.
A tri-hydroxy cyclohexene carboxylic acid important in biosynthesis of so many compounds that the shikimate pathway is named after it.
Sharks of the family Squalidae, also called dogfish sharks. They comprise at least eight genera and 44 species. Their LIVER is valued for its oil and its flesh is often made into fertilizer.
A class of enzymes that catalyze the formation of a bond between two substrate molecules, coupled with the hydrolysis of a pyrophosphate bond in ATP or a similar energy donor. (Dorland, 28th ed) EC 6.
A simple organophosphorus compound that inhibits DNA polymerase, especially in viruses and is used as an antiviral agent.
A compound formed in the liver from ammonia produced by the deamination of amino acids. It is the principal end product of protein catabolism and constitutes about one half of the total urinary solids.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
An enzyme that, in the course of pyrimidine biosynthesis, catalyzes ring closure by removal of water from N-carbamoylaspartate to yield dihydro-orotic acid. EC 3.5.2.3.
Derivatives of GLUTAMIC ACID. Included under this heading are a broad variety of acid forms, salts, esters, and amides that contain the 2-aminopentanedioic acid structure.
5'-Uridylic acid. A uracil nucleotide containing one phosphate group esterified to the sugar moiety in the 2', 3' or 5' position.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
The modification of the reactivity of ENZYMES by the binding of effectors to sites (ALLOSTERIC SITES) on the enzymes other than the substrate BINDING SITES.
A rather large group of enzymes comprising not only those transferring phosphate but also diphosphate, nucleotidyl residues, and others. These have also been subdivided according to the acceptor group. (From Enzyme Nomenclature, 1992) EC 2.7.
Enzymes that catalyze the epimerization of chiral centers within carbohydrates or their derivatives. EC 5.1.3.
One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter.
Amino-substituted glyoxylic acid derivative.
The parts of a macromolecule that directly participate in its specific combination with another molecule.
A genus of strictly anaerobic ultrathermophilic archaea, in the family THERMOCOCCACEAE, occurring in heated seawaters. They exhibit heterotrophic growth at an optimum temperature of 100 degrees C.
The key substance in the biosynthesis of histidine, tryptophan, and purine and pyrimidine nucleotides.
Enzymes that catalyze the joining of glutamine-derived ammonia and another molecule. The linkage is in the form of a carbon-nitrogen bond. EC 6.3.5.
An adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.
An essential amino acid that is physiologically active in the L-form.
An ester of glucose with phosphoric acid, made in the course of glucose metabolism by mammalian and other cells. It is a normal constituent of resting muscle and probably is in constant equilibrium with fructose-6-phosphate. (Stedman, 26th ed)
Ribulose substituted by one or more phosphoric acid moieties.
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
Purines attached to a RIBOSE and a phosphate that can polymerize to form DNA and RNA.
Mitochondria in hepatocytes. As in all mitochondria, there are an outer membrane and an inner membrane, together creating two separate mitochondrial compartments: the internal matrix space and a much narrower intermembrane space. In the liver mitochondrion, an estimated 67% of the total mitochondrial proteins is located in the matrix. (From Alberts et al., Molecular Biology of the Cell, 2d ed, p343-4)
Pyrimidines with a RIBOSE and phosphate attached that can polymerize to form DNA and RNA.
Azoles with an OXYGEN and a NITROGEN next to each other at the 1,2 positions, in contrast to OXAZOLES that have nitrogens at the 1,3 positions.
A group of enzymes that catalyze the transfer of carboxyl- or carbamoyl- groups. EC 2.1.3.
Pesticides used to destroy unwanted vegetation, especially various types of weeds, grasses (POACEAE), and woody plants. Some plants develop HERBICIDE RESISTANCE.
A compound that, along with its isomer, Cleland's reagent (DITHIOTHREITOL), is used for the protection of sulfhydryl groups against oxidation to disulfides and for the reduction of disulfides to sulfhydryl groups.
The study of crystal structure using X-RAY DIFFRACTION techniques. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
The facilitation of a chemical reaction by material (catalyst) that is not consumed by the reaction.
The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH = log 1/2[1/(H+)], where (H+) is the hydrogen ion concentration in gram equivalents per liter of solution. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
Antibiotic substance produced by various Streptomyces species. It is an inhibitor of enzymatic activities that involve glutamine and is used as an antineoplastic and immunosuppressive agent.
A compound that inhibits aminobutyrate aminotransferase activity in vivo, thereby raising the level of gamma-aminobutyric acid in tissues.
An isomer of glucose that has traditionally been considered to be a B vitamin although it has an uncertain status as a vitamin and a deficiency syndrome has not been identified in man. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1379) Inositol phospholipids are important in signal transduction.
A characteristic feature of enzyme activity in relation to the kind of substrate on which the enzyme or catalytic molecule reacts.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
Genetically engineered MUTAGENESIS at a specific site in the DNA molecule that introduces a base substitution, or an insertion or deletion.
The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain).
Derivatives of OXALOACETIC ACID. Included under this heading are a broad variety of acid forms, salts, esters, and amides that include a 2-keto-1,4-carboxy aliphatic structure.
An enzyme of the urea cycle that catalyzes the formation of argininosuccinic acid from citrulline and aspartic acid in the presence of ATP. Absence or deficiency of this enzyme causes the metabolic disease CITRULLINEMIA in humans. EC 6.3.4.5.
Organic salts of cyanic acid containing the -OCN radical.
The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.
A species of ascomycetous fungi of the family Sordariaceae, order SORDARIALES, much used in biochemical, genetic, and physiologic studies.
Calcium salts of phosphoric acid. These compounds are frequently used as calcium supplements.
Derivatives of ammonium compounds, NH4+ Y-, in which all four of the hydrogens bonded to nitrogen have been replaced with hydrocarbyl groups. These are distinguished from IMINES which are RN=CR2.
A four-carbon sugar that is found in algae, fungi, and lichens. It is twice as sweet as sucrose and can be used as a coronary vasodilator.
Enzymes that catalyze the dehydrogenation of GLYCERALDEHYDE 3-PHOSPHATE. Several types of glyceraldehyde-3-phosphate-dehydrogenase exist including phosphorylating and non-phosphorylating varieties and ones that transfer hydrogen to NADP and ones that transfer hydrogen to NAD.
Ribose substituted in the 1-, 3-, or 5-position by a phosphoric acid moiety.
A genus of ascomycetous fungi, family Sordariaceae, order SORDARIALES, comprising bread molds. They are capable of converting tryptophan to nicotinic acid and are used extensively in genetic and enzyme research. (Dorland, 27th ed)
The degree of similarity between sequences of amino acids. This information is useful for the analyzing genetic relatedness of proteins and species.
Enzymes that catalyze the interconversion of aldose and ketose compounds.
A ureahydrolase that catalyzes the hydrolysis of arginine or canavanine to yield L-ornithine (ORNITHINE) and urea. Deficiency of this enzyme causes HYPERARGININEMIA. EC 3.5.3.1.
A non-essential amino acid. It is found primarily in gelatin and silk fibroin and used therapeutically as a nutrient. It is also a fast inhibitory neurotransmitter.
Inorganic salts that contain the -HCO3 radical. They are an important factor in determining the pH of the blood and the concentration of bicarbonate ions is regulated by the kidney. Levels in the blood are an index of the alkali reserve or buffering capacity.
Enzyme that catalyzes the first step of the tricarboxylic acid cycle (CITRIC ACID CYCLE). It catalyzes the reaction of oxaloacetate and acetyl CoA to form citrate and coenzyme A. This enzyme was formerly listed as EC 4.1.3.7.
Enzymes of the isomerase class that catalyze reactions in which a group can be regarded as eliminated from one part of a molecule, leaving a double bond, while remaining covalently attached to the molecule. (From Enzyme Nomenclature, 1992) EC 5.5.
Systems of enzymes which function sequentially by catalyzing consecutive reactions linked by common metabolic intermediates. They may involve simply a transfer of water molecules or hydrogen atoms and may be associated with large supramolecular structures such as MITOCHONDRIA or RIBOSOMES.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
A metallic element that has the atomic symbol Mg, atomic number 12, and atomic weight 24.31. It is important for the activity of many enzymes, especially those involved in OXIDATIVE PHOSPHORYLATION.
An aldotriose which is an important intermediate in glycolysis and in tryptophan biosynthesis.
The five-carbon building blocks of TERPENES that derive from MEVALONIC ACID or deoxyxylulose phosphate.
Enzymes of the isomerase class that catalyze the transfer of acyl-, phospho-, amino- or other groups from one position within a molecule to another. EC 5.4.
A family of 6-membered heterocyclic compounds occurring in nature in a wide variety of forms. They include several nucleic acid constituents (CYTOSINE; THYMINE; and URACIL) and form the basic structure of the barbiturates.
Derivatives of SUCCINIC ACID. Included under this heading are a broad variety of acid forms, salts, esters, and amides that contain a 1,4-carboxy terminated aliphatic structure.
A water-soluble, colorless crystal with an acid taste that is used as a chemical intermediate, in medicine, the manufacture of lacquers, and to make perfume esters. It is also used in foods as a sequestrant, buffer, and a neutralizing agent. (Hawley's Condensed Chemical Dictionary, 12th ed, p1099; McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1851)
A subclass of enzymes of the transferase class that catalyze the transfer of an amino group from a donor (generally an amino acid) to an acceptor (generally a 2-keto acid). Most of these enzymes are pyridoxyl phosphate proteins. (Dorland, 28th ed) EC 2.6.1.
The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.
Multicellular, eukaryotic life forms of kingdom Plantae (sensu lato), comprising the VIRIDIPLANTAE; RHODOPHYTA; and GLAUCOPHYTA; all of which acquired chloroplasts by direct endosymbiosis of CYANOBACTERIA. They are characterized by a mainly photosynthetic mode of nutrition; essentially unlimited growth at localized regions of cell divisions (MERISTEMS); cellulose within cells providing rigidity; the absence of organs of locomotion; absence of nervous and sensory systems; and an alternation of haploid and diploid generations.
Enzymes that catalyze the cleavage of a carbon-carbon bond of a 3-hydroxy acid. (Dorland, 28th ed) EC 4.1.3.
Inorganic derivatives of phosphoric acid (H3PO4). Note that organic derivatives of phosphoric acids are listed under ORGANOPHOSPHATES.
An enzyme that catalyzes the transfer of D-glucose from UDPglucose into 1,4-alpha-D-glucosyl chains. EC 2.4.1.11.
A site on an enzyme which upon binding of a modulator, causes the enzyme to undergo a conformational change that may alter its catalytic or binding properties.
Carbamoyl-Phosphate+Synthase+(Glutamine-Hydrolyzing) at the US National Library of Medicine Medical Subject Headings (MeSH) ... glutamine) glutamine-dependent carbamyl phosphate synthetase carbamoyl phosphate synthetase CPS carbon-dioxide:L-glutamine ... Carbamoyl-phosphate synthetase (glutamine-hydrolysing) is also known as: hydrogen-carbonate:L-glutamine amido-ligase (ADP- ... Carbamoyl phosphate synthetase II (EC 6.3.5.5) is an enzyme that catalyzes the reactions that produce carbamoyl phosphate in ...
... carbamoyl-phosphate synthase (glutamine-hydrolyzing) MeSH D08.811.464.259.550 - formate-tetrahydrofolate ligase MeSH D08.811. ... carbamoyl-phosphate synthase (ammonia) MeSH D08.811.464.259.400 - carbon-nitrogen ligases with glutamine as amide-n-donor MeSH ... Glutamate synthase (ferredoxin) MeSH D08.811.913.477.700.500 - glutamine-fructose-6-phosphate transaminase (isomerizing) MeSH ... riboflavin synthase MeSH D08.811.913.225.825 - spermidine synthase MeSH D08.811.913.225.912 - spermine synthase MeSH D08.811. ...
... by enzyme ribose-phosphate diphosphokinase (PRPS1). PRPP is then converted to 5-phosphoribosylamine (5-PRA) as glutamine ... Phosphodiester bonds, when hydrolyzed, release a considerable amount of free energy. Therefore, nucleic acids tend to ... begins with the conversion of Aspartate to N-Carbamoylaspartate by undergoing a condensation reaction with carbamoyl phosphate ... closure of the second ring structure is carried out by IMP synthase to form IMP, where IMP fate would lead to the formation of ...
... phosphate synthase (glutamine hydrolyzing) EC 4.3.3.7: 4-hydroxy-tetrahydrodipicolinate synthase EC 4.3.99.1: now EC 4.2.1.104 ... carbamoyl-serine ammonia-lyase EC 4.3.1.14: 3-aminobutyryl-CoA ammonia-lyase EC 4.3.1.15: diaminopropionate ammonia-lyase EC ... 11-diene synthase EC 4.2.3.25: S-linalool synthase EC 4.2.3.26: R-linalool synthase EC 4.2.3.27: isoprene synthase EC 4.2.3.28 ... d-cadinene synthase EC 4.2.3.14: pinene synthase EC 4.2.3.15: myrcene synthase EC 4.2.3.16: (4S)-limonene synthase EC 4.2.3.17 ...
Argininosuccinate synthase. *Holocarboxylase synthetase. *GMP synthase. *Asparagine synthetase. *Carbamoyl phosphate synthetase ... the tRNA is found to be improperly charged), the aminoacyl-tRNA bond is hydrolyzed. This can happen when two amino acids have ... Ludmerer SW, Schimmel P (August 1987). "Construction and analysis of deletions in the amino-terminal extension of glutamine ...
Carbamoyl phosphate synthetase I. *Ornithine transcarbamylase. *N-Acetylglutamate synthase. alcohol metabolism. *ALDH2 ... The reaction follows the same steps as the transamination reaction but does not hydrolyze the tautomerized Schiff base. The ... pyridoxal phosphate binding. • hydrolase activity. • 3-hydroxykynureninase activity. Cellular component. • cytosol. • ... phosphate (PLP) dependent enzymes. To date, two structures of human kynureninase have determined by X-ray diffraction with ...
Carbamoyl phosphate synthase II. *Aspartate carbamoyltransferase. *Dihydroorotase. *Dihydroorotate dehydrogenase. *Orotidine 5 ... Production of IMP from PRPP requires glutamine, glycine, aspartate, and 6 ATP, among other things.[1] IMP is then converted to ... The nucleoside, adenosine, is then deaminated and hydrolyzed to form hypoxanthine via adenosine deaminase and nucleosidase ... XMP is then converted into GMP by using the hydrolysis of 1 ATP and the conversion of glutamine to glutamate.[1] AMP and GMP ...
carbamoyl phosphate synthase (glutamine-hydrolyzing) activity, carbamoyl phosphate synthetase activity, carbamoyl-phosphate ... carbamoyl-phosphate synthetase (glutamine-hydrolysing) activity, carbamoyl-phosphate synthetase (glutamine-hydrolyzing) ... Gene Ontology Term: carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity. GO ID. GO:0004088 Aspect. Molecular Function ... glutamine-dependent carbamoyl-phosphate synthase activity, glutamine-dependent carbamyl phosphate synthetase activity, hydrogen ...
... carbamoylphosphate synthase and albumin, that are generally accepted markers for the hepatic phenotype, require a distinct set ... Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing) / genetics* * DNA Probes * DNA, Complementary / analysis * DNA, ... Expression of alpha-fetoprotein, carbamoylphosphate synthase and albumin, that are generally accepted markers for the hepatic ... carbamoylphosphate synthase and lactase mRNA Histochem J. 1994 Jan;26(1):20-31. ...
... glutamine-hydrolyzing) activity, cellular response to amino acid stimulus, glutamate metabolic process, glutamine metabolic ... Carbamoyl-phosphate synthase large chain (carB), Carbamoyl-phosphate synthase small chain (carA) ... Carbamoyl-phosphate synthase large chain (carB), Carbamoyl-phosphate synthase small chain (carA) ... carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity Source: PseudoCAP ,p>Inferred from Direct Assay,/p> ,p>Used to ...
Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing) / genetics * Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing) / ... Map-based cloning showed that the VEN3 and VEN6 genes encode subunits of Arabidopsis carbamoyl phosphate synthetase (CPS), ... Carbon-Nitrogen Ligases with Glutamine as Amide-N-Donor / genetics * Carbon-Nitrogen Ligases with Glutamine as Amide-N-Donor / ...
Carbamoyl-phosphate synthase pyrimidine-specific large chain (pyrAB), Carbamoyl-phosphate synthase (glutamine-hydrolyzing) ( ... carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity Source: UniProtKB-EC. View the complete GO annotation on QuickGO ... 2 ATP + L-glutamine + HCO3- + H2O = 2 ADP + phosphate + L-glutamate + carbamoyl phosphate. ... Carbamoyl-phosphate synthase pyrimidine-specific small chain (EC:6.3.5.5). Alternative name(s): ...
Argininosuccinate Synthase / analysis. Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing) / analysis. Dexamethasone / ... EC 6.3.4.5/Argininosuccinate Synthase; EC 6.3.5.5/Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing) ...
107748079 gmps; GMP synthase [glutamine-hydrolyzing] 107741925 LOW QUALITY PROTEIN: carbamoyl-phosphate synthase [ammonia] ... carbamoyl-phosphate synthase (ammonia) [EC:6.3.4.16] K11540 CAD; carbamoyl-phosphate synthase / aspartate carbamoyltransferase ... 107749915 glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2-like 107710818 glutamine--fructose-6-phosphate ... 107756803 glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2-like 107752562 glutamine--fructose-6-phosphate ...
carbamoyl-phosphate synthase (glutamine-hydrolyzing) CPA1. protein-coding. AHP1. thioredoxin peroxidase AHP1. protein-coding. ...
carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity. 2.64774423341735. bayes_pls_golite062009. *biotin carboxylase ... ATP citrate synthase activity [ISS][NAS] succinate-CoA ligase (ADP-forming) activity [IEA] ...
Carbamoyl-Phosphate+Synthase+(Glutamine-Hydrolyzing) at the US National Library of Medicine Medical Subject Headings (MeSH) ... glutamine) glutamine-dependent carbamyl phosphate synthetase carbamoyl phosphate synthetase CPS carbon-dioxide:L-glutamine ... Carbamoyl-phosphate synthetase (glutamine-hydrolysing) is also known as: hydrogen-carbonate:L-glutamine amido-ligase (ADP- ... Carbamoyl phosphate synthetase II (EC 6.3.5.5) is an enzyme that catalyzes the reactions that produce carbamoyl phosphate in ...
Heat sensitivity and Sp1 activation of complex formation at the Syrian hamster carbamoyl-phosphate synthase (glutamine- ... hydrolyzing)/aspartate carbamoyltransferase/dihydroorotase promoter in vitro J Biol Chem. 1992 Jan 05; 267(1):385-91. . View in ...
... carbamoyl-phosphate synthase (glutamine-hydrolyzing) MeSH D08.811.464.259.550 - formate-tetrahydrofolate ligase MeSH D08.811. ... carbamoyl-phosphate synthase (ammonia) MeSH D08.811.464.259.400 - carbon-nitrogen ligases with glutamine as amide-n-donor MeSH ... Glutamate synthase (ferredoxin) MeSH D08.811.913.477.700.500 - glutamine-fructose-6-phosphate transaminase (isomerizing) MeSH ... riboflavin synthase MeSH D08.811.913.225.825 - spermidine synthase MeSH D08.811.913.225.912 - spermine synthase MeSH D08.811. ...
GMP synthase (glutamine-hydrolysing) [EC:6.3.5.2] K01948 CPS1; carbamoyl-phosphate synthase (ammonia) [EC:6.3.4.16] K11540 CAD ... 109392785 GFPT2; glutamine-fructose-6-phosphate transaminase 2 109394795 ASNS; asparagine synthetase (glutamine-hydrolyzing) ... 109390430 CPS1; carbamoyl-phosphate synthase 1 109380279 CAD; carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and ... glutamine---fructose-6-phosphate transaminase (isomerizing) [EC:2.6.1.16] K01953 asnB; asparagine synthase (glutamine- ...
Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing) 34 Citations Comparison of enzymatic reactivity of corn stover solids ...
Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing) 8 Citations Non-linear numerical study of the single-fiber fragmentation ...
Carbamoyl-phosphate synthase (glutamine-hydrolyzing) 0.960. R2601_11831. carA. R2601_11831. R2601_19422. Dihydropyrimidine ... Orotate phosphoribosyltransferase ; Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to ... Orotate phosphoribosyltransferase ; Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to ... Orotate phosphoribosyltransferase ; Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to ...
Carbamoyl-phosphate synthase (glutamine-hydrolyzing) Transcript cleavage factor GreA ; Necessary for efficient RNA polymerase ... tRNA-dihydrouridine synthase ; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most ... tRNA-dihydrouridine synthase ; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most ... tRNA-dihydrouridine synthase ; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most ...
... carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity; carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity; ...
glutamine-hydrolyzing carbamoyl-phosphate synthase small subunit. Page. *1*2*3*4*5*6*7*8*9*10*11*12*13*14*15*16*17*18*19*20*21* ...
Carbamoyl-phosphate synthetase (CPS) contains a small amidotransferase subunit (GLN) that hydrolyzes glutamine and transfers ... In Lactobacillus plantarum, Carbamoyl Phosphate Is Synthesized by Two Carbamoyl-Phosphate Synthetases (CPS): Carbon Dioxide ... In Lactobacillus plantarum, Carbamoyl Phosphate Is Synthesized by Two Carbamoyl-Phosphate Synthetases (CPS): Carbon Dioxide ... In Lactobacillus plantarum, Carbamoyl Phosphate Is Synthesized by Two Carbamoyl-Phosphate Synthetases (CPS): Carbon Dioxide ...
GO:0004088 carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity. GO:0005524 ATP binding. ... carbamoyl-phosphate transferase-arginine (subunit A). Enzyme Classifications. EC 6.3.5.5: carbamoyl-phosphate synthase ( ... LPhT) Cells were harvested (i) during exponential growth in high phosphate defined medium [HPh]; (ii) during exponential growth ... at three hours after the outset of the phosphate-limitation induced stationary phase [LPhT].. ...
GO; GO:0004088; F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity; IDA:BHF-UCL.. GO; GO:0004151; F:dihydroorotase ... CPS1 Gene carbamoyl-phosphate synthase 1, mitochondrial. CPSM_RAT. Rat ELISA Kit FOR Carbamoyl-phosphate synthase [ammonia], ... Rat Carbamoyl-phosphate synthase [ammonia], mitochondrial(CPS1) ELISA kit. 96T. CSB-EL005913HU. Human Carbamoyl-phosphate ... Carbamoyl-phosphate synthase [ammonia], mitochondrial,Carbamoyl-phosphate synthetase I,Cps1,CPSase I,Rat,Rattus norvegicus. ...
enables carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity (IDA) Biological Process. Manually Curated. * involved in ... involved in glutamine metabolic process (IDA) * involved in negative regulation of pyrimidine nucleobase metabolic process (IDA ... Bifunctional carbamoylphosphate synthetase/aspartate transcarbamylase; catalyzes the first two enzymatic steps in the de novo ...
The SCOP classification for the Carbamoyl phosphate synthetase, small subunit N-terminal domain superfamily including the ... Carbamoyl-phosphate synthase (ammonia). Enzyme Commission (EC). Carbamoyl-phosphate synthase (glutamine-hydrolyzing). 0. 2.05. ... Carbamoyl-phosphate synthase catalyses the ATP-dependent synthesis of carbamoyl-phosphate from glutamine or ammonia and ... Carbamoyl-phosphate synthase (glutamine-hydrolyzing). 0. Highly Informative. Direct. Enzyme Commission (EC). Dihydroorotase. ...
The SCOP classification for the Carbamoyl phosphate synthetase, large subunit connection domain superfamily including the ... Carbamoyl-phosphate synthase (ammonia). Enzyme Commission (EC). Carbamoyl-phosphate synthase (glutamine-hydrolyzing). 0. 2.049 ... Carbamoyl-phosphate synthase (glutamine-hydrolyzing). 0. Highly Informative. Direct. Enzyme Commission (EC). Dihydroorotase. ... Carbamoyl-phosphate synthase (CPSase) catalyzes the ATP-dependent synthesis of carbamyl-phosphate from glutamine or ammonia and ...
Carbamoyl-phosphate synthase (glutamine-hydrolyzing)2 ATP + L-glutamine + HCO3(-) + H2O = 2 ADP + phosphate + L-glutamate + ... Carbamoyl-phosphate synthase small chain, CPSase domain (PF00988; HMM-score: 167.7) Glutaminase_I (CL0014) GATase; Glutamine ... product: carbamoyl phosphate synthase small subunit. ⊟Genome View[edit source , edit]. Meta Function Gene Functional Class ( ... Nucleosides and NucleotidesPyrimidinesDe Novo Pyrimidine Synthesis Carbamoyl-phosphate synthase small chain (EC 6.3.5.5) ...
Carbamoyl-phosphate synthase (glutamine-hydrolyzing)2 ATP + L-glutamine + HCO3(-) + H2O = 2 ADP + phosphate + L-glutamate + ... Carbamoyl-phosphate synthase small chain, CPSase domain (PF00988; HMM-score: 167.7) Glutaminase_I (CL0014) GATase; Glutamine ... product: carbamoyl-phosphate synthase small chain. ⊟Genome View[edit source , edit]. Meta Function Gene Functional Class ( ... MetabolismPurines, pyrimidines, nucleosides, and nucleotidesPyrimidine ribonucleotide biosynthesiscarbamoyl-phosphate synthase ...
... carbamoylphosphate (CP) is a precursor common to the synthesis of arginine and pyrimidines. In Escherichia coliand most other ... Glutamine hydrolyzing site of Escherichia coli carbamyl phosphate synthetase. J Biol Chem 261:11320-11327PubMedGoogle Scholar ... coli carbamoylphosphate synthase (pdb-1JDB) [133]. The small, carA encoded, glutamine amidotransferase subunit (magenta), and ... carbamoyl phosphate is synthesized by two carbamoyl-phosphate synthetases (CPS): carbon dioxide differentiates the arginine- ...
GO:0004087 - carbamoyl-phosphate synthase (ammonia) activity. GO:0004088 - carbamoyl-phosphate synthase (glutamine-hydrolyzing ... GO:0003922 - GMP synthase (glutamine-hydrolyzing) activity. GO:0003921 - GMP synthase activity. GO:0005525 - GTP binding. GO: ... glutamine + FGAR. L-glutamate + phosphate + FGAM. Name:. glutamine + FGAR -> L-glutamate + phosphate + FGAM ... GO:0005951 - carbamoyl-phosphate synthase complex. GO:0005737 - cytoplasm. GO:0005829 - cytosol. GO:0031234 - extrinsic ...
Start Site Selection at the TATA-less Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing)/Aspartate Carbamoyltransferase/ ...
  • Map-based cloning showed that the VEN3 and VEN6 genes encode subunits of Arabidopsis carbamoyl phosphate synthetase (CPS), which is assumed to be required for the conversion of ornithine into citrulline in arginine biosynthesis. (nih.gov)
  • Carbamoyl phosphate synthetase II (EC 6.3.5.5) is an enzyme that catalyzes the reactions that produce carbamoyl phosphate in the cytosol (as opposed to type I, which functions in the mitochondria). (wikipedia.org)
  • Carbamoyl-phosphate synthetase (glutamine-hydrolysing) is also known as: hydrogen-carbonate:L-glutamine amido-ligase (ADP-forming, carbamate-phosphorylating) carbamyl phosphate synthetase (glutamine) glutamine-dependent carbamyl phosphate synthetase carbamoyl phosphate synthetase CPS carbon-dioxide:L-glutamine amido-ligase (ADP-forming, carbamate-phosphorylating) Anderson PM, Meister A (December 1965). (wikipedia.org)
  • Glutamine-dependent carbamyl phosphate synthetase. (wikipedia.org)
  • Carbamoyl-phosphate synthetase (CPS) contains a small amidotransferase subunit (GLN) that hydrolyzes glutamine and transfers ammonia to the large synthetase subunit (SYN), where CP biosynthesis occurs in the presence of ATP and CO 2 . (asm.org)
  • CP synthetase (CPS) catalyzes the synthesis of CP from bicarbonate, glutamine, and two molecules of ATP via a complex reaction mechanism that leads to several unstable intermediates. (asm.org)
  • The heterodimeric CPS enzyme is composed of a small subunit (GLN) which functions as a glutamine amidotransferase and a large synthetase subunit (SYN) that fulfills the other catalytic properties (for a review, see reference 4 ). (asm.org)
  • Mammalian carbamyl phosphate synthetase (CPS). (antibody-antibodies.com)
  • Identification of the junction between the glutamine amidotransferase and carbamyl phosphate synthetase domains of the mammalian CAD protein. (antibody-antibodies.com)
  • This gene encodes a trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis: carbamoylphosphate synthetase (CPS II), aspartate transcarbamoylase, and dihydroorotase. (thermofisher.com)
  • Carbamoyl phosphate synthetase (CPS) is technically not a member of the urea cycle. (conservapedia.com)
  • A key regulatory step is the production of ribose-5-phospho-α-D-ribosyl 1-pyrophosphate (PRPP) by PRPP synthetase, which is activated by inorganic phosphate and inactivated by purine ribonucleotides. (wikibooks.org)
  • Other names in common use include GMP synthetase (glutamine-hydrolysing), guanylate synthetase (glutamine-hydrolyzing), guanosine monophosphate synthetase (glutamine-hydrolyzing), xanthosine 5'-phosphate amidotransferase, and guanosine 5'-monophosphate synthetase. (wikibooks.org)
  • In animals, the de novo pathway is initiated and controlled by CAD, a ∼240‐kDa multifunctional protein with four different enzymatic domains: glutaminase (GLN), carbamoyl phosphate synthetase (CPS), dihydroorotase (DHO) and aspartate transcarbamoylase (ATC). (els.net)
  • CAD is a 243‐kDa polypeptide with four enzymatic domains [glutaminase (GLN), carbamoyl phosphate synthetase (CPS), dihydroorotase (DHO) and aspartate transcarbamoylase (ATC)] that oligomerises into 1.5‐megaDa hexamers. (els.net)
  • The enzyme which accomplishes this is called glutamine synthetase. (drugbank.ca)
  • The key regulatory enzyme of the teleost OUC, carbamoyl phosphate synthetase III (CPSase III), was expressed predominantly in muscle of developing C. gariepinus larvae and showed negligible activity in the absence of its allosteric effector N -acetyl- l -glutamate. (biologists.org)
  • Therefore, one would expect that glutamine synthetase, the enzyme responsible for the amidation of glutamate, plays a central role in the regulation of nitrogen metabolism. (rpi.edu)
  • The first, found in most tissues, uses glutamine synthetase to combine ammonia with glutamate to form glutamine-a nontoxic transport form of ammonia (Figure 19.13). (slideplayer.com)
  • Formation of carbamoyl phosphate by carbamoyl phosphate synthetase I is driven by cleavage of two molecules of ATP. (slideplayer.com)
  • Carbamoyl phosphate synthetase I requires N-acetylglutamate as a positive allosteric activator (see Figure 19.14). (slideplayer.com)
  • Carbamoyl phosphate synthetase II participates in the biosynthesis of pyrimidines (see p. 302). (slideplayer.com)
  • Steady-state kinetic analysis of these compounds found that a localized negative charge on the inhibitor that mimics the phosphate group is essential to ligand binding in asparagine synthetase. (ufl.edu)
  • However, site-directed mutagenesis, kinetic analysis, and isotopic labeling studies of the glutamine-dependent asparagine synthetase from E. coli found that this residue is critical to formation of the ?AspAMP intermediate. (ufl.edu)
  • Carbamoyl phosphate (CP) is an intermediate in pyrimidine and arginine biosynthesis. (asm.org)
  • Glutamine can then be used as a nitrogen donor in the biosynthesis of many compounds, including other amino acids, purines, and pyrimidines. (drugbank.ca)
  • During acetate metabolism proteins involved in the lipid metabolism and hexosamine biosynthesis were over-expressed in the acetate medium, while proteins involved in TCA cycle, pentose phosphate cycle and purine metabolism were down-regulated. (ijbs.com)
  • Oxidation is thought to occur with transfer of hydride ion from glutamate's C α to NAD(P) + , thereby forming α-iminoglutarate, which is hydrolyzed to α-ketoglutarate and ammonia. (conservapedia.com)
  • In the first step, catalyzed by glutamine-PRPP amidotransferase, glutamine acts as a source of ammonia and PPi (inorganic pyrophosphate) is released. (wikibooks.org)
  • Glutamine is used again in the fourth step as a source of ammonia. (wikibooks.org)
  • Ammonia (formed by nitrogen fixation) is assimilated into organic compounds by converting glutamic acid to glutamine. (drugbank.ca)
  • The glutamine is transported in the blood to the liver where it is cleaved by glutaminase to produce glutamate and free ammonia (see p. 256). (slideplayer.com)
  • Ammonia incorporated into carbamoyl phosphate is provided primarily by the oxidative deamination of glutamate by mitochondrial glutamate dehydrogenase (see Figure 19.11). (slideplayer.com)
  • Catalysis of the reaction: 2 ATP + L-glutamine + CO2 + H2O = 2 ADP + phosphate + glutamate + carbamoyl phosphate. (yeastgenome.org)
  • 2 ATP + L-glutamine + HCO 3 - + H 2 O = 2 ADP + phosphate + L-glutamate + carbamoyl phosphate. (uniprot.org)
  • Alternatively, N-carbamoyl glutamate (NCG) is structural analogue of N-acetyl glutamate, cofactor of cabamoyl phosphate synthetase1, is lower in rumen degradation compared to ARG. (biomedcentral.com)
  • Asparagine and glutamine are the products of amidations of aspartate and glutamate, respectively. (rpi.edu)
  • Formation of carbamoyl phosphate: Aspartate 1 F. Oraby's illustrated reviews of biochemistry 20 B. Carbon atom: Protein metabolism 21 N. (homeranking.info)
  • Arginine from the diet or from protein turnover is hydrolyzed by the enzyme arginase ( Wood, 1993 ). (biologists.org)
  • Glutamine is also crucial in nitrogen metabolism. (drugbank.ca)
  • In all organisms, carbamoylphosphate (CP) is a precursor common to the synthesis of arginine and pyrimidines. (springer.com)
  • Flow of nitrogen from ambto acid Formation of citrulline: Carbamoyl phosphate synthase II is a cytosolic enzyme used for pyrimidine synthesis. (homeranking.info)
  • a) CP synthesis from glutamine, bicarbonate and two ATP molecules. (els.net)
  • We demonstrated that deoxycytidine could be readily achieved by recombineering with biosynthetic genes and regulatory genes, which appeared to enhance the supply of precursors for synthesis of carbamoyl phosphate, based on transcriptome analysis. (biomedcentral.com)
  • Purines are biologically synthesized as nucleotides (bases attached to ribose 5-phosphate). (wikibooks.org)
  • Ornithine combines with carbamoyl phosphate to make citrulline. (studyblue.com)
  • CPSase III and ornithine carbamoyl transferase activities increased in fed larvae compared with starved larvae. (biologists.org)
  • The 6th one is N- acetylglutamate that acts as allosteric activator of carbamoyl phosphate synthase I. Arginine ': Then urea is transported by the blood to. (homeranking.info)
  • The key enzyme of urea cycle is carbamoyl phosphate synthase I. (homeranking.info)
  • In teleosts, urea may also be formed from glutamine, HCO 3 −1 , ATP and aspartate by the OUC ( Anderson, 1995 ). (biologists.org)
  • The release of this PPi can lead to its cleavage to form two inorganic phosphates. (wikibooks.org)
  • The release of the high-energy phosphate of carbamoyl phosphate as inorganic phosphate drives the reaction in the forward direction. (slideplayer.com)
  • They also offer a mechanism by which the binding of activators like inorganic phosphate enables the activation loop to communicate with the active site to ensure maximal rates of catalysis, and promotes the opening of the lid to achieve optimal product release. (antibodies-online.com)
  • The enzyme Glycogen synthase catalyzes the addition of glucose molecules at the nonreducing end of core glycogen molecule In this reaction, an activated UDP-glucose molecule forms 1-4 glycosidic linkage with existing glucose moiety of glycogen molecule and free UDP is liberated. (medicalbiochemist.com)
  • Catalysis of the reaction: ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. (leibniz-fli.de)
  • Catalysis of the reaction: 5-phospho-D-ribosylamine + ATP + glycine = N(1)-(5-phospho-D-ribosyl)glycinamide + ADP + 2 H(+) + phosphate. (leibniz-fli.de)
  • Catalysis of the reaction: succinate + CoA + nucleotide triphosphate = nucleotide diphosphate + phosphate + succinyl-CoA. (leibniz-fli.de)
  • Catalysis of the reaction: ATP + succinate + CoA = ADP + succinyl-CoA + phosphate. (leibniz-fli.de)
  • The first committed step is the reaction of PRPP, glutamine and water to 5'-phosphoribosylamine, glutamine, and pyrophosphate - catalyzed by pyrophosphate amidotransferase, which is activated by PRPP and inhibited by AMP, GMP and IMP. (wikibooks.org)
  • All of the other ATP-involving steps that follow harness the energy of hydrolysis of a phosphate bond of ATP (exergonic) to drive an endergonic reaction. (rpi.edu)
  • The reaction follows the same steps as the transamination reaction but does not hydrolyze the tautomerized Schiff base . (wikipedia.org)
  • Both adenine and guanine are derived from the nucleotide inosine monophosphate (IMP), which is synthesised on a pre-existing ribose-phosphate through a complex pathway using atoms from the amino acids glycine, glutamine, and aspartic acid, as well as formate ions transferred from the coenzyme tetrahydrofolate [1] . (wikibooks.org)
  • The amino acid glycine contributes all its carbon 2 and nitrogen 1 atoms, with additional nitrogen atoms from glutamine 2 and aspartic acid 1and additional carbon atoms from formyl groups 2which are transferred from the coenzyme tetrahydrofolate as formyltetrahydrofolateand a carbon atom from bicarbonate 1. (smartone.host)
  • phosphate esters of a pentose sugar (either ribose or deoxyribose) in which a purine or pyrimidine base is linked to C1 of the sugar. (kasinokamu.com)
  • This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds carbon-nitrogen ligases with glutamine as amido-N-donor. (wikibooks.org)
  • The CBS enzyme is located on the long arm of chromosome 21 (21q22.3) and the mutation of the CBS gene may result in reduced activity of cystathionine beta-synthase resulting in classical homocystinuria. (medicalbiochemist.com)
  • Kynureninase belongs to the class V group of aspartate aminotransferase superfamily of structurally homologous pyridoxal 5'-phosphate ( PLP ) dependent enzymes. (wikipedia.org)
  • It catalyzes the condensation and activation of NH 4 + and HCO 3 - to form carbamoyl phosphate, the first of the cycle's two nitrogen-containing substrates, with the concomitant hydrolysis of two ATPs. (conservapedia.com)
  • In Escherichia coli and most other Gram-negative bacteria, CP is produced by a single enzyme, carbamoylphosphate synthase (CPSase), encoded by the carAB operon. (springer.com)
  • ATP activates the ribose-5-phosphate by adding a pyrophosphate group (PP i ) to C 1 of the sugar (i.e., there is a group transfer). (rpi.edu)
  • This compound interacts with water and L-glutamine through a amidophosphoribosyl transferase resulting in a pyrophosphate, L-glutamic acid and a 5-phosphoribosylamine. (kasinokamu.com)
  • Figure 2: Glycogen Synthase-addition of glucose from UDP-glucose to core glycogen molecules. (medicalbiochemist.com)
  • Acute lymphoblastic leukemia is commonly treated using the enzyme L asparaginase, which hydrolyzes asparagine to aspartic acid, leaving the tumor cells unable to obtain asparagine from the circulating plasma. (ufl.edu)
  • Its systemic name is hydrogen-carbonate:L-glutamine amido-ligase (ADP-forming, carbamate-phosphorylating). (wikipedia.org)
  • The systematic name of this enzyme class is xanthosine-5'-phosphate:L-glutamine amido-ligase (AMP-forming). (wikibooks.org)
  • Interestingly, cardiac mesoderm, which induces prehepatic endoderm to liver formation, is temporarily permissive to its own signals, showing enhanced expression of these transcription factors and, as a result, the hepatocyte-specific genes alpha-fetoprotein and carbamoylphosphate synthase. (nih.gov)
  • Under these conditions, the genes necessary for conversion of L-glutamine to carbamoyl-P, conversion of PRPP to 5-phospho-ribosyl-amine, conversion of 5-phospho-ribosyl-amine until to IMP, cyclization of carbamoyl-aspartate to dihydroorotate and its conversion to orotate, conversion of serine to 5, 10-tetrahydrofolate are not expressed. (unam.mx)
  • Less detailed: The presence of hypoxanthine inhibits the expression of genes needful for conversion of L-glutamine to carbamoyl-P, conversion of PRPP to 5-phospho-ribosyl-amine, conversion of 5-phospho-ribosyl-amine until to IMP, cyclization of carbamoyl-aspartate to dihydroorotate and its conversion to orotate, conversion of serine to 5, 10-tetrahydrofolate. (unam.mx)
  • The Calvin Cycle , earlier designated the photosynthetic "dark reactions" pathway, is where the free energy of cleavage of phosphate bonds of ATP, and reducing power of NADPH, are used to fix and reduce CO2 to form carbohydrate. (weebly.com)
  • It is formed from ribose 5-phosphate by the enzyme ribose-phosphate diphosphokinase. (wikibooks.org)
  • ATP is involved in 6 of the steps, but we will see that an additional ATP is needed to form a -D-Ribose-5-phosphate, the first molecule in the pathway. (rpi.edu)
  • That's a lot of ATPs, and therefore, so as not to be wasteful, nature very effectively salvages derivatives of purines in recycling pathways.The ribose-5-phosphate is produced in the pentose phosphate pathway, which you have already studied. (rpi.edu)
  • We have already discussed the formation of ribose-5-phosphate as part of the pentose phosphate pathway. (kasinokamu.com)
  • The six membered pyrimidine ring is made first and then attached to ribose phosphate. (kasinokamu.com)
  • GLS1 inhibition using BPTES reduced metabolic intermediates including thymidine and carbamoyl phosphate. (antibodies-online.com)
  • Catalysis of the formation of a phosphodiester bond between the 3'-hydroxyl group at the end of one DNA chain and the 5'-phosphate group at the end of another. (leibniz-fli.de)
  • Nucleoside kinases are enzymes which catalyse the transfer of γâ phosphate from adenosine triphosphate to nucleosides leading to formation of nucleosideâ 5' â monophosphates. (kasinokamu.com)