DiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and Processes
CarbamazepineAnticonvulsantsPhenytoinValproic AcidPrimidoneEpilepsyAntimanic AgentsTrigeminal NeuralgiaEpilepsies, PartialEthosuximideTriazinesEpilepsy, Complex PartialFluorescence Polarization ImmunoassayPhenobarbitalWater IntoxicationDrug EruptionsDibenzazepinesStevens-Johnson SyndromeEpilepsy, Tonic-ClonicClonazepamDrug InteractionsLithium CarbonateHLA-B15 AntigenSeizuresDrug HypersensitivityEpilepsy, GeneralizedAlcohol Withdrawal SeizuresPhenylethylmalonamideElectroshockPiracetamCytochrome P-450 CYP3A
Carbamazepine
An anticonvulsant used to control grand mal and psychomotor or focal seizures. Its mode of action is not fully understood, but some of its actions resemble those of PHENYTOIN; although there is little chemical resemblance between the two compounds, their three-dimensional structure is similar.
Anticonvulsants
Drugs used to prevent SEIZURES or reduce their severity.
Phenytoin
An anticonvulsant that is used to treat a wide variety of seizures. It is also an anti-arrhythmic and a muscle relaxant. The mechanism of therapeutic action is not clear, although several cellular actions have been described including effects on ion channels, active transport, and general membrane stabilization. The mechanism of its muscle relaxant effect appears to involve a reduction in the sensitivity of muscle spindles to stretch. Phenytoin has been proposed for several other therapeutic uses, but its use has been limited by its many adverse effects and interactions with other drugs.
Valproic Acid
A fatty acid with anticonvulsant properties used in the treatment of epilepsy. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of voltage dependent sodium channels.
Primidone
An antiepileptic agent related to the barbiturates; it is partly metabolized to PHENOBARBITAL in the body and owes some of its actions to this metabolite. Adverse effects are reported to be more frequent than with PHENOBARBITAL. (From Martindale, The Extra Pharmacopoeia, 30th ed, p309)
Epilepsy
A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)
Antimanic Agents
Agents that are used to treat bipolar disorders or mania associated with other affective disorders.
Trigeminal Neuralgia
A syndrome characterized by recurrent episodes of excruciating pain lasting several seconds or longer in the sensory distribution of the TRIGEMINAL NERVE. Pain may be initiated by stimulation of trigger points on the face, lips, or gums or by movement of facial muscles or chewing. Associated conditions include MULTIPLE SCLEROSIS, vascular anomalies, ANEURYSMS, and neoplasms. (Adams et al., Principles of Neurology, 6th ed, p187)
Epilepsies, Partial
Conditions characterized by recurrent paroxysmal neuronal discharges which arise from a focal region of the brain. Partial seizures are divided into simple and complex, depending on whether consciousness is unaltered (simple partial seizure) or disturbed (complex partial seizure). Both types may feature a wide variety of motor, sensory, and autonomic symptoms. Partial seizures may be classified by associated clinical features or anatomic location of the seizure focus. A secondary generalized seizure refers to a partial seizure that spreads to involve the brain diffusely. (From Adams et al., Principles of Neurology, 6th ed, pp317)
Ethosuximide
An anticonvulsant especially useful in the treatment of absence seizures unaccompanied by other types of seizures.
Triazines
Heterocyclic rings containing three nitrogen atoms, commonly in 1,2,4 or 1,3,5 or 2,4,6 formats. Some are used as HERBICIDES.
Epilepsy, Complex Partial
A disorder characterized by recurrent partial seizures marked by impairment of cognition. During the seizure the individual may experience a wide variety of psychic phenomenon including formed hallucinations, illusions, deja vu, intense emotional feelings, confusion, and spatial disorientation. Focal motor activity, sensory alterations and AUTOMATISM may also occur. Complex partial seizures often originate from foci in one or both temporal lobes. The etiology may be idiopathic (cryptogenic partial complex epilepsy) or occur as a secondary manifestation of a focal cortical lesion (symptomatic partial complex epilepsy). (From Adams et al., Principles of Neurology, 6th ed, pp317-8)
Fluorescence Polarization Immunoassay
Fluoroimmunoassay where detection of the hapten-antibody reaction is based on measurement of the increased polarization of fluorescence-labeled hapten when it is combined with antibody. The assay is very useful for the measurement of small haptenic antigens such as drugs at low concentrations.
Phenobarbital
A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
Water Intoxication
A condition resulting from the excessive retention of water with sodium depletion.
Drug Eruptions
Adverse cutaneous reactions caused by ingestion, parenteral use, or local application of a drug. These may assume various morphologic patterns and produce various types of lesions.
Dibenzazepines
Compounds with two BENZENE rings fused to AZEPINES.
Stevens-Johnson Syndrome
Rare cutaneous eruption characterized by extensive KERATINOCYTE apoptosis resulting in skin detachment with mucosal involvement. It is often provoked by the use of drugs (e.g., antibiotics and anticonvulsants) or associated with PNEUMONIA, MYCOPLASMA. It is considered a continuum of Toxic Epidermal Necrolysis.
Epilepsy, Tonic-Clonic
A generalized seizure disorder characterized by recurrent major motor seizures. The initial brief tonic phase is marked by trunk flexion followed by diffuse extension of the trunk and extremities. The clonic phase features rhythmic flexor contractions of the trunk and limbs, pupillary dilation, elevations of blood pressure and pulse, urinary incontinence, and tongue biting. This is followed by a profound state of depressed consciousness (post-ictal state) which gradually improves over minutes to hours. The disorder may be cryptogenic, familial, or symptomatic (caused by an identified disease process). (From Adams et al., Principles of Neurology, 6th ed, p329)
Clonazepam
An anticonvulsant used for several types of seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop. It is seldom effective in generalized tonic-clonic or partial seizures. The mechanism of action appears to involve the enhancement of GAMMA-AMINOBUTYRIC ACID receptor responses.
Drug Interactions
The action of a drug that may affect the activity, metabolism, or toxicity of another drug.
Lithium Carbonate
A lithium salt, classified as a mood-stabilizing agent. Lithium ion alters the metabolism of BIOGENIC MONOAMINES in the CENTRAL NERVOUS SYSTEM, and affects multiple neurotransmission systems.
HLA-B15 Antigen
A specific HLA-B surface antigen subtype. Members of this subtype contain alpha chains that are encoded by the HLA-B*15 allele family.
Seizures
Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or "seizure disorder."
Drug Hypersensitivity
Immunologically mediated adverse reactions to medicinal substances used legally or illegally.
Epilepsy, Generalized
Recurrent conditions characterized by epileptic seizures which arise diffusely and simultaneously from both hemispheres of the brain. Classification is generally based upon motor manifestations of the seizure (e.g., convulsive, nonconvulsive, akinetic, atonic, etc.) or etiology (e.g., idiopathic, cryptogenic, and symptomatic). (From Mayo Clin Proc, 1996 Apr;71(4):405-14)
Alcohol Withdrawal Seizures
A condition where seizures occur in association with ethanol abuse (ALCOHOLISM) without other identifiable causes. Seizures usually occur within the first 6-48 hours after the cessation of alcohol intake, but may occur during periods of alcohol intoxication. Single generalized tonic-clonic motor seizures are the most common subtype, however, STATUS EPILEPTICUS may occur. (Adams et al., Principles of Neurology, 6th ed, p1174)
Phenylethylmalonamide
A metabolite of primidone.
Electroshock
Induction of a stress reaction in experimental subjects by means of an electrical shock; applies to either convulsive or non-convulsive states.
Piracetam
A compound suggested to be both a nootropic and a neuroprotective agent.
Cytochrome P-450 CYP3A
A cytochrome P-450 suptype that has specificity for a broad variety of lipophilic compounds, including STEROIDS; FATTY ACIDS; and XENOBIOTICS. This enzyme has clinical significance due to its ability to metabolize a diverse array of clinically important drugs such as CYCLOSPORINE; VERAPAMIL; and MIDAZOLAM. This enzyme also catalyzes the N-demethylation of ERYTHROMYCIN.

Differential display PCR reveals novel targets for the mood-stabilizing drug valproate including the molecular chaperone GRP78. (1/723)

Differential display polymerase chain reaction was used to identify genes regulated by the mood-stabilizing drug valproate (VPA). Four differentially displayed valproate-regulated gene fragments were isolated in rat cerebral cortex after i.p. injection of sodium VPA (300 mg/kg) for 3 weeks, and their expression was confirmed by Northern and slot blot analysis in rat cerebral cortex and C6 glioma cells. Sequencing analysis revealed three previously unidentified cDNA fragments in addition to a sequence with 100% homology with a molecular chaperone, 78-kDa glucose-regulated protein (GRP78). VPA treatment did not increase mRNA expression of 70-kDa heat shock protein, which is a related stress-induced molecular chaperone protein. All four candidate genes, including GRP78, showed similar VPA concentration-dependent increases in mRNA abundance. Another commonly prescribed mood-stabilizing anticonvulsant, carbamazepine, also increased GRP78 mRNA expression in C6 glioma cells, whereas lithium had no effect at doses up to 2 mM. Immunoblotting revealed that GRP78 protein levels were also increased in C6 glioma cells treated with VPA under the same conditions. Nuclear runoff analysis showed that VPA increased GRP78 gene transcription. Because GRP78 possesses molecular chaperone activity, binds Ca2+ in the endoplasmic reticulum, and protects cells from the deleterious effects of damaged proteins, the present findings suggest that VPA (and possibly carbamazepine) treatment may target one or more of these processes.  (+info)

Carbamazepine-induced upregulation of adenosine A1-receptors in astrocyte cultures affects coupling to the phosphoinositol signaling pathway. (2/723)

The anticonvulsant and antibipolar drug carbamazepine (CBZ) is known to act as a specific antagonist at adenosine A1-receptors. After a 3-week application of CBZ, A1-receptors are upregulated in the rat brain. We have investigated the consequences of this upregulation for the A1-receptor-mediated signal transduction in primary astrocyte cultures from different regions of the rat brain. CBZ treatment for 10 days had no effect on adenosine A1-receptor mRNA expression in cultures with high basal A1-receptor mRNA levels, but increased A1-receptor mRNA in cultures exhibiting low basal A1-receptor mRNA levels. This upregulation of A1-receptor mRNA was accompanied by an upregulation or induction of A1-receptor-mediated potentiation of PLC activity, a property that was not found in these cultures before CBZ treatment. Thus, CBZ treatment for 10 days induces a new quality of adenosine A1-receptor-mediated signal transduction in cells that express low basal A1-receptor numbers.  (+info)

Carbamazepine facilitates effects of GABA on rat hippocampus slices. (3/723)

AIM: To study the influence of carbamazepine (Car) on GABA effect in hippocampus. METHODS: Evoked potentials were recorded on pyramidal cells in CA1 after stimulation (0.5 Hz, 50 microseconds) to Schaffer collaterals in rat hippocampal slices (350 microns). RESULTS: Car 0.1 and 0.2 mmol.L-1 did not affect field potentials, whereas Car 0.2 mmol.L-1 plus GABA (0.1-1 mmol.L-1) gave rise to a stronger inhibition on field potentials than that of GABA alone. Bicuculline did not reverse Car facilitation on GABA inhibition on field potentials. (-)-Baclofen was more effective in inhibiting field potentials than GABA. Car 0.2 mmol.L-1 plus (-)-baclofen (1-5 mumol.L-1) brought an inhibition stronger than that of (-)-baclofen alone. CONCLUSION: Car facilitates the effects of GABA on pyramidal cells in hippocampal CA1 region, probably related to GABAB receptors.  (+info)

Outcome of pregnancies in epileptic women: a study in Saudi Arabia. (4/723)

We studied the outcome of 79 pregnancies in 44 Saudi women who had epilepsy. Their mean age was 28+/-6.5 years and the number of pregnancies studied varied from one to six. Nineteen subjects had generalized seizures, 16 had partial seizures and nine were unclassified. The commonest drug prescribed was carbamazepine and the majority of the women (61%) were on monotherapy. The seizures were controlled in 53 pregnancies (67%). Spontaneous vertex deliveries were the commonest. The indications for intervention by lower segment Caesarean section, forceps or ventouse were foetal distress, pre-eclamptic toxaemia (PET), eclampsia, breech presentation and prolonged labour. The most frequent adverse outcome in the babies was low birth weight (<2.5 kg) in nine pregnancies. The frequency of congenital malformation was 2.5%. Low birth weight was associated with prematurity, PET, congenital malformation and polytherapy. Avoidance of polytherapy appears to be the most feasible intervention in reducing the frequency of low birth-weight children by epileptic mothers.  (+info)

Clinical and EEG findings in complex partial status epilepticus with tiagabine. (5/723)

A case of complex partial status epilepticus (CPSE) with high dose treatment of tiagabine (TGB) is reported. Seizure aggravation and CPSE developed after stepwise increase of TGB to a dose of 60 mg per day as add-on treatment to carbamazepine (CBZ) 1200 mg/day and vigabatrine (VGB) 1000 mg/day. The EEG during CPSE showed bilateral rhythmic slow activity. Clinical symptoms of CPSE and the EEG normalized after i.v. treatment with clonazepam. The literature and the possible mechanism of this paradoxical phenomenon are discussed.  (+info)

Does withdrawal of different antiepileptic drugs have different effects on seizure recurrence? Further results from the MRC Antiepileptic Drug Withdrawal Study. (6/723)

One thousand and thirteen patients, in remission of epilepsy for at least 2 years, were randomized to continued therapy or slow withdrawal over 6 months and were followed up for a median period of 5 years. At the time of randomization 83% of patients were receiving monotherapy with carbamazepine (237 patients), phenobarbitone/primidone (72 patients), phenytoin (184 patients) or valproate (228 patients) in low doses, and plasma levels were below the usual optimal range. The most important factor determining seizure recurrence was continued therapy, which was the case for barbiturates, phenytoin and valproate. There was no significant difference for patients taking carbamazepine at randomization, because of a low rate of recurrence in those withdrawing treatment. The difference between carbamazepine and other drugs was not explained by differences in covariate prognostic factors. There was no evidence that withdrawal of phenobarbitone was associated with withdrawal seizures. These data provide unique evidence for the effectiveness of standard antiepileptic drugs as monotherapy. The results for carbamazepine may be open to a number of interpretations.  (+info)

Anticonvulsant-induced dyskinesias: a comparison with dyskinesias induced by neuroleptics. (7/723)

Anticonvulsants cause dyskinesias more commonly than has been appreciated. Diphenylhydantoin (DPH), carbamazepine, primidone, and phenobarbitone may cause asterixis. DPH, but not other anticonvulsants, may cause orofacial dyskinesias, limb chorea, and dystonia in intoxicated patients. These dyskinesias are similar to those caused by neuroleptic drugs and may be related to dopamine antagonistic properties possessed by DPH.  (+info)

Bipolar disorder in old age. (8/723)

OBJECTIVE: To review the classification, clinical characteristics, and epidemiology of bipolar disorders in old age with a special focus on neurologic comorbidity, high mortality, and management. QUALITY OF EVIDENCE: Most available data is gleaned from retrospective chart reviews and cohort studies. Treatment recommendations are based on evidence from younger populations and a few anecdotal case reports and series involving elderly people. MAIN MESSAGE: While relatively rare in the community setting, mania in old age frequently leads to hospitalization. It is associated with late-onset neurologic disorders (especially cerebrovascular disease) involving the right hemisphere and orbitofrontal cortex. Prognosis is relatively poor; morbidity and mortality rates are high. Management of bipolarity includes cautious use of mood stabilizers, especially lithium and divalproex. CONCLUSIONS: Mania in old age should trigger a careful assessment of underlying neurologic disease, especially cerebrovascular disease. Close clinical follow up is essential.  (+info)

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Carbamazepine in Severe Liver Disease Due to Alpha-1 Antitrypsin Deficiency - Full Text View - ClinicalTrials.govCarbamazepine in Severe Liver Disease Due to Alpha-1 Antitrypsin Deficiency - Full Text View - ClinicalTrials.gov
The primary objective is to determine if Carbamazepine therapy in patients with severe liver disease due to Alpha-1-Antitrypsin Deficiency leads to a significant reduction in the hepatic accumulation of ATZ.. The other objectives are:. To determine whether Carbamazepine treatment reduces hepatic fibrosis in alpha-1-antitrypsin deficient patients with severe liver disease. To determine whether Carbamazepine treatment reduces portal pressure in alpha-1-antitrypsin deficient patients with severe liver disease. To determine whether Carbamazepine treatment is safe and tolerated by patients with severe liver disease caused by alpha-1-deficiency. To determine whether Carbamazepine treatment leads to stabilization in disease severity as measured by the MELD scores. ...
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Main / Womens Health / Crushing carbamazepine Carbamazepine extended-release capsules do not need to be taken with meals unless they upset your stomach. The contents of the extended-release capsules may be sprinkled over a teaspoon of applesauce or other similar food. The capsule or its contents should not be crushed or chewed. The extended-release tablets. GUIDELINES FOR BREAKING OR CRUSHING TABLETS. The reasons for considering tablet crushing are numerous, however crushing tablets has impact on efficacy and the potential for side effects, particularly in drugs with a narrow therapeutic window including: Phenytoin. Digoxin. Carbamazepine. Sodium valproate.. Do not crush or crushing carbamazepine the extended-release capsules or the kidneys inside them. Shake the liquid well before each use to mix the decision crushing carbamazepine. Your doctor will start you on a low dose of carbamazepine and crushing carbamazepine find your dose. Carbamazepine may do crushing carbamazepine your condition, but ...
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Lacosamide vs Controlled-Release Carbamazepine Monotherapy as Initial Epilepsy Treatment - AsociaciĆ³n de Medicina Interna de El...
Lacosamide vs Controlled-Release Carbamazepine Monotherapy as Initial Epilepsy Treatment. Information sourced from NEJM Journal Watch:. Lacosamide vs. Controlled-Release Carbamazepine Monotherapy as Initial Epilepsy Treatment. Lacosamide was no less effective for new-onset seizures in patients with clinically suspected partial epilepsy.. Nearly all new antiepilepsy medications (AEDs) obtain initial indications as adjunctive (add-on) therapy in patients with medically uncontrolled epilepsy, yet most patients are treated (or wish to be) with only one medicine. Very few head-to-head comparisons have been done between new AEDs and older medications with established efficacy in the largest generalizable populations: those with new-onset seizures or those that can be controlled with one AED. Lacosamide (LCM) is FDA-approved as monotherapy based on historical controls and is not approved as monotherapy in Europe. This large international, double-blind, randomized, manufacturer-sponsored study compared ...
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Favorable response to carbamazepine therapy in genetically proven myoclonus-dystonia child | SpringerLinkFavorable response to carbamazepine therapy in genetically proven myoclonus-dystonia child | SpringerLink
Myoclonus dystonia (MDS) is a dominantly inherited genetic disorder caused by loss-of-function mutations in the epsilon sarcoglycan gene (SGCE). We here in report a twenty months old Saudi boy who presented to us with a concern that the child is unable to walk properly. On assessment, he was flexing his left arm and left leg that usually followed by a back-ward fall. Diagnosis of dystonia induced with initiation of movement was suggested that later on proven genetically to be pathogenic mutation of sarcoglycan gene. Carbamazepine therapy was initiated with dramatic response. Response was maintained at 4 years follow up. Our patient and the other previously reported cases might highlight the response of SGCE mutations to carbamazepine therapy.
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Carbamazepine has a potential for drug interactions; caution should be used in combining other medicines with it, including other antiepileptics and mood stabilizers.[12] Lower levels of carbamazepine are seen when administrated with phenobarbital, phenytoin, or primidone, which can result in breakthrough seizure activity. Carbamazepine, as a CYP450 inducer, may increase clearance of many drugs, decreasing their concentration in the blood to subtherapeutic levels and reducing their desired effects.[19] Drugs that are more rapidly metabolized with carbamazepine include warfarin, lamotrigine, phenytoin, theophylline, and valproic acid.[12] Drugs that decrease the metabolism of carbamazepine or otherwise increase its levels include erythromycin,[20] cimetidine, propoxyphene, and calcium channel blockers.[12] Carbamazepine also increases the metabolism of the hormones in birth control pills and can reduce their effectiveness, potentially leading to unexpected pregnancies.[12] As a drug that induces ...
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Change in haloperidol level due to carbamazepine- a complicating factor in combined medication for Schizophrenia<...Change in haloperidol level due to carbamazepine- a complicating factor in combined medication for Schizophrenia<...
TY - JOUR. T1 - Change in haloperidol level due to carbamazepine- a complicating factor in combined medication for Schizophrenia. AU - Kahn, E. Michael. AU - Schulz, S. Charles. AU - Perel, James M.. AU - Alexander, Jane E.. PY - 1990/2. Y1 - 1990/2. N2 - Serum haloperidol levels were measured in patients who received haloperidol alone and, subsequently, haloperidol in combination with carbamazepine or lithium carbonate. Haloperidol levels and the level-dose ratios dropped about 50% in patients receiving carbamazepine. They remained the same in most patients receiving lithium carbonate. One patient receiving added carbamazepine experienced worsening of symptoms; this was associated with a drop in serum haloperidol level. Two other patients receiving added carbamazepine showed significant symptom reduction, although they also sustained drops in serum haloperidol levels. It is not clear whether these two individuals benefited from a primary antipsychotic effect of carbamazepine or from reduction ...
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Find patient medical information for Carbamazepine Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Learn about side effects, interactions and indications Initial dose: 200 mg orally 2 times a day (immediate and extended release) or 100 mg orally 4 times a.. Carbamazepine Oral tablet, extended release 200mg Drug Medication Dosage information. Learn about the reported side effects, related class drugs, and how. Carbamazepine: learn about side effects, dosage, special precautions, and more on MedlinePlus. Carbamazepine is an epilepsy medication used to prevent seizures. It may also be used for bipolar disorder and trigeminal neuralgia. Some of these errors led to serious side effects in patients Common Side Effects of Tegretol: Carbamazepine 200 mg-TEV, white, round.. Learn about side effects, warnings, dosage, and more First dose: 200 mg taken by mouth 2 clomid despues de un ciclo per day; Dose changes: Your doctor may increase your ...
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The foetal outcomes of 2,635 pregnancies recorded in the Australian Pregnancy Register were studied. In at least the initial 4 months of 515 pregnancies, there had been no intrauterine exposure to antiepileptic drugs, though the women involved in 264 of these pregnancies took antiepileptic drugs in later pregnancies. Compared with these 515 drug-unexposed pregnancies, foetal malformations risks were increased more than five-fold in association with valproate monotherapy, and more than doubled in association with carbamazepine monotherapy (p , 0.05). There were no statistically significant increases in malformation rates associated with other more commonly used antiepileptic drugs, while the malformation risk in relation to levetiracetam exposure was lower than that in the drug-unexposed pregnancies. The published literature has rather consistently shown raised malformation rates associated with carbamazepine monotherapy, though only once was it statistically significant. There now appears to be ...
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Hyperhomocysteinaemia in children receiving phenytoin and carbamazepine monotherapy: a cross-sectional observational study |...Hyperhomocysteinaemia in children receiving phenytoin and carbamazepine monotherapy: a cross-sectional observational study |...
Results A total of 112 children receiving antiepileptic monotherapy for ,6 months were enrolled. Hyperhomocysteinaemia was present in 54 children (90%) receiving phenytoin, 45 children (90%) receiving carbamazepine therapy and 17 (34%) controls (p,0.05). Mean plasma homocysteine concentrations were significantly higher (18.9Ā±10.2 vs 9.1Ā±3 Āµmol/L) and serum folic acid concentrations (10.04Ā±8.5 ng/ml vs 12.6Ā±4.8 p,0.001) and vitamin B12 concentrations (365Ā±155 pg/mL vs 474Ā±332 pg/mL, p=0.02) were significantly lower in the study group compared with the control group. Duration of antiepileptic drug therapy correlated significantly with elevated homocysteine and reduced folic acid concentrations (p,0.05). Supplementation with folic acid for 1 month led to a reduction in plasma homocysteine concentrations in the study group (from 20.9Ā±10.3 Āµmol/L to 14.2Ā±8.2 Āµmol/L, p,0.05). ...
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Carbamazepine (CBZ), sold under the trade name Tegretol among others, is an anticonvulsant medication used primarily in the treatment of epilepsy and neuropathic pain.[1] It is not effective for absence or myoclonic seizures.[1] It is used in schizophrenia along with other medications and as a second-line agent in bipolar disorder.[3][1] Carbamazepine appears to work as well as phenytoin and valproate for focal and generalised seizures.[4] Common side effects include nausea and drowsiness.[1] Serious side effects may include skin rashes, decreased bone marrow function, suicidal thoughts, or confusion.[1] It should not be used in those with a history of bone marrow problems.[1] Use during pregnancy may cause harm to the baby; however, stopping the medication in pregnant women with seizures is not recommended.[1] Its use during breastfeeding is not recommended.[1] Care should be taken in those with either kidney or liver problems.[1] Carbamazepine was discovered in 1953 by Swiss chemist Walter ...
https://en.wikipedia.org/wiki/Tegretol
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Drug Reaction with Eosinophilia and Systemic Symptom (DRESS) induced by carbamazepine: a case report and literature reviewDrug Reaction with Eosinophilia and Systemic Symptom (DRESS) induced by carbamazepine: a case report and literature review
Drug-induced hypersensitivity or Drug Reaction with Eosinophilia and Systemic Symptom (DRESS) is a severe adverse drug-induced reaction. Diagnosing DRESS is challenging due to the diversity of cutaneous eruption and organs involved. Most of the aromatic anticonvulsants, such as phenytoin, phenobarbital, and carbamazepine, can induce DRESS. Culprit drug withdrawal and corticosteroids constituted the mainstay of DRESS treatment. We describe a 6 year-old boy who presented fever and rash 4 weeks after starting carbamazepine. Investigation revealed leukocytosis, atypical lymphocytosis, and elevated serum transaminases. The diagnosis of DREES syndrome was made, Carbamazepine was stopped and replaced initially by Clobazam and by Valproic acid after discharge, no systemic corticotherapy was prescribed. Symptoms began to resolve within two weeks, and by one month later her laboratory values had returned to normal. The aim of this work is to raise awareness general practitioner and pediatricians to suspect Dress
http://panafrican-med-journal.com/content/article/18/9/full/
Carbamazepine and Its -10,11-Epoxide Metabolite in Plasma and CSF: Relationship to Antidepressant Response | JAMA Psychiatry |...Carbamazepine and Its -10,11-Epoxide Metabolite in Plasma and CSF: Relationship to Antidepressant Response | JAMA Psychiatry |...
ā€¢ Levels of carbamazepine and its -10,11-epoxide metabolite were measured in plasma and CSF of affectively ill patients treated only with carbamazepine for an a
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Background: Augmentation strategies in schizophrenia treatment remain an important issue because despite the introduction of several new antipsychotics, many patients remain treatment resistant. The aim of this study was to undertake a systematic review and meta-analysis of the safety and efficacy of one frequently used adjunctive compound: carbamazepine. Data sources and study selection: Randomized controlled trials comparing carbamazepine (as a sole or as an adjunctive compound) with placebo or no intervention in participants with schizophrenia or schizoaffective disorder were searched for by accessing 7 electronic databases, cross-referencing publications cited in pertinent studies, and contacting drug companies that manufacture carbamazepine. Method: The identified studies were independently inspected and their quality assessed by 2 reviewers. Because the study results were generally incompletely reported, original patient data were requested from the authors; data were received for 8 of the ...
http://www.psychiatrist.com/JCP/article/Pages/2002/v63n03/v63n0308.aspx
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https://rbej.biomedcentral.com/articles/10.1186/1477-7827-10-22
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A side effect of carbamazepine therapy that might be anticipated from its antidiuretic action in neurohypophyseal diabetes insipidus (1) is water intoxication with hyponatremia. Three such cases, including one patient who developed pulmonary edema on rechallenge, have been reported (2). Our patient developed pulmonary edema followed by inappropriate antidiuresis during treatment with carbamazepine. Asymptomatic hypothyroidism remained untreated during the time we observed water intoxication.. A 76-year-old man first experienced in 1961 pain of trigeminal neuralgia in the distribution of the right first and second branches, triggered by biting, chewing, or shaving and associated with tearing in the right eye. Serum ...
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Evaluation of anticonvulsant activity of magnesium oxide alone and along with carbamazepine<...
TY - JOUR. T1 - Evaluation of anticonvulsant activity of magnesium oxide alone and along with carbamazepine. AU - Patil, Navin A.. AU - Somashekar, H. S.. AU - Narendranath, S.. AU - Prashanth, AU - Reddy, Suneel Kumar. AU - Bhandarkar, Anoosha. PY - 2012/4/1. Y1 - 2012/4/1. N2 - Objectives: To evaluate the anticonvulsant effect of magnesium oxide alone and its activity alongside carbamazepine in albino rats. Materials and methods: In MES (maximal electric shock) method, 36 male albino rats weighing between 100-200gm, were divided into 6 groups each containing 6 animals were all treated with magnesium oxide (500,1000mg/kg) for 10 days orally. On 11th day Carbamazepine (50,30mg/Kg) was given orally an hour before MES induced seizures except control and only magnesium oxide groups. Abolition of tonic hind limb extention reflex and time taken to regain righting reflex were noted for each animal after MES induced seizures. Results: Low dose oral administration (500mg/kg) for 10 days in healthy rat ...
https://manipal.pure.elsevier.com/en/publications/evaluation-of-anticonvulsant-activity-of-magnesium-oxide-alone-an
Treating trigeminal neuralgia in MS - The MS-BlogTreating trigeminal neuralgia in MS - The MS-Blog
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https://multiple-sclerosis-research.org/2017/10/treating-trigeminal-neuralgia-in-ms/?replytocom=47905
Analysis of the antinociceptive interactions in two-drug combinations of gabapentin, oxcarbazepine and amitriptyline in...Analysis of the antinociceptive interactions in two-drug combinations of gabapentin, oxcarbazepine and amitriptyline in...
Antiepileptic and antidepressant drugs are the primary treatments for pain relief in diabetic neuropathy. Combination therapy is a valid approach in pain treatment, where a reduction of doses could reduce side effects and still achieve optimal analgesia. We examined the effects of two-drug combinations of gabapentin, oxcarbazepine, and amitriptyline on nociception in diabetic mice and aimed to determine the type of interaction between components. The nociceptive responses in normal and diabetic mice were assessed by the tail-flick test. The testing was performed before and three weeks after the diabetes induction with streptozotocin (150 mg/kg; i.p.), when the antinociceptive effects of gabapentin, oxcarbazepine, amitriptyline and their two-drug combinations were examined. Gabapentin (10-40 mg/kg; p.o.) and oxcarbazepine (20-80 mg/kg; p.o.) produced a significant, dose-dependent antinociception in diabetic mice while amitriptyline (5-60 mg/kg; p.o.) produced weak antinociceptive effect.... In ...
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Influence of genetic variability on the clinical pharmacology of carbamazepine and lamotrigine - Enlighten: ThesesInfluence of genetic variability on the clinical pharmacology of carbamazepine and lamotrigine - Enlighten: Theses
This research programme investigates the influence of genetic variability on the clinical pharmacology of carbamazepine (CBZ) and lamotrigine (LTG).. Common polymorphisms in genes that may influence the response to CBZ and LTG include CYP3A4 g.-392A,G, CYP3A5 g.6986A,G, CYP1A2 g.5734C,A, EPHX1 c.337T,C, EPHX1 c.416A,G, UGT2B7 c.802C,T, ABCB1 c.1236C,T, ABCB1 c.2677G,T/A, ABCB1 c.3435C,T and SCN2A c.56G,A.. The prevalence of these common polymorphisms was evaluated in a 400-strong study population from a single research unit. Minor allele frequency ranged between 3.5% (CYP3A4 -392G) and 48.0% (ABCB1 1236T). Allele and genotype distributions were comparable to published data for other Caucasian populations.. The influence of common polymorphisms in drug metabolising enzyme (DME) and sodium channel genes on the optimal dose of CBZ was assessed in a cohort of 70 patients. This study revealed that age and common polymorphisms in the EPHX1 gene (c.337T,C and c.416A,G) are potential predictors for ...
http://theses.gla.ac.uk/1778/
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my mother had to take me to the doctor to day, and he wrote a prescription on Tegretol/Carbamazepine, start 100 mg 4 times a day. And sobril (its like valium) Im willing to try everything now because this is crisis. I HATE taking so many meds, and specially Sobil/Valium (benzo), and that none of the meds are for the CAUSE, only symptomatologic. I was on doxycycline when all this started, it started after a week on doxy, but Ive not dared to take it the latest 3 days. I have searched the net for burning scalp and there is a chance it is a Herxheimers reaction og a symptom of Lyme, and if this is Herxheimers I know I shouldnt stop the treatment, but I just had to to it because it is so bad I really dont wont to live anymore. I can not understand I actually have gotten a new symptom that is SO MUCH WORSE AND INTENSE than any other pain Ive ever felt. Didnt think that was possible. Now I would do anything to have back the situation I had before the burning scalp ...
http://www.aboutbfs.com/forums/viewtopic.php?p=136547
AboutBFS.com ā€¢ View topic - Carbamazepine
my mother had to take me to the doctor to day, and he wrote a prescription on Tegretol/Carbamazepine, start 100 mg 4 times a day. And sobril (its like valium) Im willing to try everything now because this is crisis. I HATE taking so many meds, and specially Sobil/Valium (benzo), and that none of the meds are for the CAUSE, only symptomatologic. I was on doxycycline when all this started, it started after a week on doxy, but Ive not dared to take it the latest 3 days. I have searched the net for burning scalp and there is a chance it is a Herxheimers reaction og a symptom of Lyme, and if this is Herxheimers I know I shouldnt stop the treatment, but I just had to to it because it is so bad I really dont wont to live anymore. I can not understand I actually have gotten a new symptom that is SO MUCH WORSE AND INTENSE than any other pain Ive ever felt. Didnt think that was possible. Now I would do anything to have back the situation I had before the burning scalp ...
http://www.aboutbfs.com/forums/viewtopic.php?p=136543
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I have been taking Tegretol for several months now. At first the effect was disorientation and drowsiness. But over time that effect wore off. Im taking it for Trigeminal Neuralgia. They eliminated the attacks, although the dull sharp pain would still be there at times---but no 1 minute attacks, NO tic. Then the pain started to come back and I had to increase my dosage, first from the 6 mg that was prescribed to 8 and finally I find I have to take 12 or more [6 to 8 tablets a day]. Im wondering if the effects are wearing off? At what point does it become hazardous to take? I find they work best when I now take two at a time, 3 to 4 times a day... My blood tests have been fine. I hate to keep running back to my neurologist for 10 minute consultations because of the expense [About $100 a visit]. Cant afford this. Dealing with the pain is a bitch. The best treatment isnt the Tegretol, but a 5 mile run which eliminates the pain for about 1-2 hours [Of course I need the Tegretol before I run, or ...
http://www.bio.net/bionet/mm/neur-sci/1993-December/013018.html
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Also, since first taking carbamazepine alone and niclosamide, Ive been having mild sweating at night. This suggests that appal the bicalutamide treatment might none be more able to bring everything about longer term improvements than the carbamazepine or a placebo interventions. Torrent pharmaceuticals ltd affirms safety clause of carbamazepine with signing an analysis of 5
http://pureglassbottle.com/beauty/how-does-niclosamide-treat-rheumatoid-arthritis.html
Review article: Role of Carbamazepine and Gabapentine in the Treatment of Trigeminal Neuralgia - NJMS IndiaReview article: Role of Carbamazepine and Gabapentine in the Treatment of Trigeminal Neuralgia - NJMS India
Download pdf Mobeen Khan, Panat SR, Iqubal MA, Joshi A , Kumar P, Shukla AK. Role of Carbamazepine and Gabapentine in the Treatment of Trigeminal Neuralgia. National Journal of Medical and Allied Sciences 2014; 3(1):28-32. ...
https://www.njmsonline.org/review-article-role-carbamazepine-gabapentine-treatment-trigeminal-neuralgia
DSpace at EWHA: A 6-month longitudinal study of bone mineral density with antiepileptic drug monotherapyDSpace at EWHA: A 6-month longitudinal study of bone mineral density with antiepileptic drug monotherapy
Antiepileptic drugs (AEDs) can affect bone metabolism, but the exact mechanisms or differences in individual drugs are still unknown. The purpose of this study was to prospectively investigate the alterations in bone mineral density (BMD) and markers of bone metabolism induced by different AEDs in Koreans with epilepsy. Subjects included 33 drug-naĆÆve, newly diagnosed patients with epilepsy aged between 18 and 50. BMD at right calcaneus and various markers for bone metabolism were measured before and after 6 months of AED monotherapy including carbamazepine, valproic acid, and lamotrigine. Carbamazepine caused a significant decrease in BMD, which was accompanied by a decrease in the level of vitamin D (25-OHD 3). BMD and vitamin D were not affected by 6 months of valproic acid or lamotrigine therapy. Interestingly, valproic acid and lamotrigine, but not carbamazepine, significantly increased osteocalcin, a marker of bone formation. All AEDs almost doubled the parathyroid hormone level, whereas ...
http://dspace.ewha.ac.kr/handle/2015.oak/219846
In Vivo Clearance Prediction for the UGT2B7 Substrates Carbamazepine, Diclofenac, Gemfibrozil and Zidovudine Using a...In Vivo Clearance Prediction for the UGT2B7 Substrates Carbamazepine, Diclofenac, Gemfibrozil and Zidovudine Using a...
In Vivo Clearance Prediction for the UGT2B7 Substrates Carbamazepine, Diclofenac, Gemfibrozil and Zidovudine Using a Mechanistic Population-Based Pharmacokinetic Model ...
https://www.certara.com/posters/in-vivo-clearance-prediction-for-the-ugt2b7-substrates-carbamazepine-diclofenac-gemfibrozil-and-zidovudine-using-a-mechanistic-population-based-pharmacokinetic-model/?ap%5B0%5D=PBPK
Behaviour of carbamazepine, metoprolol and naproxen in membrane bioreactor (MBR) activated sludge culture and after granular...Behaviour of carbamazepine, metoprolol and naproxen in membrane bioreactor (MBR) activated sludge culture and after granular...
Analytical analyses conducted at the HimmerfjƤrden WWTP (285.000 PE connected) identified 70 pharmaceutical compounds belonging to different therapeutic classes. Such organic micropollutants at low detected concentration range of Āµg - ng l-1 did not affect the treatment processes at WWTP. Results from analytical studies indicated continuous discharge of organic micropollutants to the surface water with a calculated load amounting to 1.51 kg day-1. Metoprolol, carbamazepine and naproxen were chosen for testing different removal methods. Oxygen Uptake Rate (OUR) tests were conducted to assess the bacterial activity of an activated sludge taken from a full scale aeration plant with the presence of selected target compounds.. A semi-technical scale membrane bioreactor ZeeWeed10ā„¢, treating final effluent from the HimmerfjƤrden WWTP (Sweden) was seeded with activated sludge from full scale biological stage. The membrane bioreactor (MBR) system placed after the final treatment appeared to be an ...
http://kth.diva-portal.org/smash/record.jsf?pid=diva2:11918
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BACKGROUND: Epilepsy is a common neurological condition with a worldwide prevalence of around 1%. Approximately 60% to 70% of people with epilepsy will achieve a longer-term remission from seizures, and most achieve that remission shortly after starting antiepileptic drug treatment. Most people with epilepsy are treated with a single antiepileptic drug (monotherapy) and current guidelines from the National Institute for Health and Care Excellence (NICE) in the United Kingdom for adults and children recommend carbamazepine or lamotrigine as first-line treatment for partial onset seizures and sodium valproate for generalised onset seizures; however a range of other antiepileptic drug (AED) treatments are available, and evidence is needed regarding their comparative effectiveness in order to inform treatment choices. OBJECTIVES: To compare the time to withdrawal of allocated treatment, remission and first seizure of 10 AEDs (carbamazepine, phenytoin, sodium valproate, phenobarbitone, oxcarbazepine, ...
http://bases.bireme.br/cgi-bin/wxislind.exe/iah/online/?IsisScript=iah/iah.xis&nextAction=lnk&base=MEDLINE&lang=p&format=detailed.pft&indexSearch=EX&exprSearch=D03.383.742.698.253.650
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Amitriptyline Amitriptyline is contraindicated in patients with a hypersensitivity to amitriptyline or any of its inactive ingredients.6 Patients with a hypersensitivity to amitriptyline may experience a tricyclic antidepressant hypersensitivity reaction to other tricyclics. In some case reports, cross-allergenicity did not occur in patients who experienced a rash from the primary tricyclic and were switched to an alternate tricyclic.7 However, because the data are too limited to be conclusive, it is generally advisable to substitute with an antidepressant from another class in patients with a known hypersensitivity to amitriptyline. When considering use of an alternate tricyclic, it is prudent to avoid other cyclic compounds if the patient has experienced a severe or life-threatening reaction to the primary agent. Cross-sensitivity is possible in patients with a carbamazepine hypersensitivity. The manufacturer of carbamazepine contraindicates use in patients with a hypersensitivity to tricyclic ...
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http://onlinelibrary.wiley.com/doi/10.1111/1346-8138.12028/pdf
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The fate of carbamazepine after intravenous injection in rats (n = 24) and the influence of activated charcoal on the kinetics was investigated. After randomization to four groups (n = 6, each), plasma concentration and the quantities of carbamazepine and metabolites excreted into bile, urine and intestine were determined using an in situ perfusion model of the small intestine (Ringers solution) with or without orally administered activated charcoal (AC+; AC-) and with or without bile duct cannulation (BD+; BD-). The cumulative amount of carbamazepine and metabolites exsorbed into the small intestine within 3.5 hr after intravenous injection was about 15% in BD- animals and about 3% in BD+ animals. About 20% of the dose was detected in the externalized bile. Activated charcoal did not influence the amount exsorbed into the small intestine. Terminal half-life in plasma ranged from 159 min. to 194 min. within the four treatment groups without statistical significant difference (P = 0.751). ...
http://mediatum.ub.tum.de/739035
Is there a way to determine who will react badly to antiepileptic medication? | Epilepsy Research UKIs there a way to determine who will react badly to antiepileptic medication? | Epilepsy Research UK
A quick, easy and inexpensive test could one day help specialists determine which epilepsy patients are likely to react badly to carbamazepine.Carbamazepine is an antiepileptic drug which is widely used as a first line treatment for epilepsy, but is also prescribed for other conditions, such as ...
https://epilepsyresearch.org.uk/is-there-a-way-to-determine-who-will-react-badly-to-carbamazepine/
Antiepileptics increase the risk of pneumonia in people with Alzheimers diseaseAntiepileptics increase the risk of pneumonia in people with Alzheimers disease
Antiepileptic drugs increase the risk of pneumonia in people living with Alzheimers disease, according to research from the University of Eastern Finland.. People with Alzheimers who used antiepileptics have twice the risk of developing pneumonia compared to those not using the drugs, the study, published in the Journal of Alzheimers Disease says.. Antiepileptic drugs phenytoin, carbamazepine, valproic acid and pregabalin were all associated with an increased risk of pneumonia. The sedative effects of antiepileptic drugs may explain the increased risk of pneumonia. Nevertheless, fewer than one in ten of those living with Alzheimers have also been diagnosed with epilepsy.. Further research into whether older persons are more sensitive to the effects of antiepileptic drugs is needed. Persons with Alzheimers disease have a higher risk of pneumonia and pneumonia-related mortality than persons without the disease. For this reason, it is important to carefully assess the risks and benefits of ...
http://pharmafile.com/print/520483
Topiramate effects on the EEG and alertness in healthy volunteers: A different profile of antiepileptic drug neurotoxicity<...Topiramate effects on the EEG and alertness in healthy volunteers: A different profile of antiepileptic drug neurotoxicity<...
TY - JOUR. T1 - Topiramate effects on the EEG and alertness in healthy volunteers. T2 - A different profile of antiepileptic drug neurotoxicity. AU - Salinsky, Martin. AU - Storzbach, Daniel. AU - Oken, Barry. AU - Spencer, David. PY - 2007/5/1. Y1 - 2007/5/1. N2 - Objective: Previous quantitative EEG (QEEG) studies of carbamazepine (CBZ), oxcarbazepine (OXC), and phenytoin (PHT) revealed a pattern of EEG slowing and an increase in drowsiness on the awake maintenance task (AMT). EEG slowing has been shown to correlate with negative effects on cognitive tests. Topiramate (TPM) is a novel AED with relatively large negative effects on cognitive function. We tested the hypothesis that TPM would induce significant slowing of EEG background rhythms and an increase in AMT drowsiness. Methods: Forty healthy volunteers were randomized to TPM, gabapentin (GBP), or placebo. Doses were escalated as tolerated to a maximum of 400 mg/day for TPM or 3600 mg/day for GBP, over a 10-week period, followed by a ...
https://ohsu.pure.elsevier.com/en/publications/topiramate-effects-on-the-eeg-and-alertness-in-healthy-volunteers-2
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Szamel, Katalin and BalĆ”zs, IstvĆ”n and BordĆ”s, MĆ”ria and Boros, Anita and Gajduschek, Gyƶrgy and HalĆ”sz, IvĆ”n and Imre, MiklĆ³s and Koi, Gyula and KristĆ³, Katalin and LővĆ©tei, IstvĆ”n and Rixer, ƁdĆ”m and Sipos, Katalin and Szamel, Katalin and TamĆ”s, AndrĆ”s and Temesi, IstvĆ”n (2012) Az EU tagĆ”llamainak kƶzigazgatĆ”si rendszere = Public Administration in the EU Member States. Project Report. OTKA. KovĆ”cs L., GĆ”bor and Fekete, SĆ”ndor and Miseta, Attila and Nagy, TamĆ”s and OsvĆ”th, PĆ©ter and PoĆ³r, Viktor Soma and Rideg, Orsolya and Sipos, Katalin (2012) A hangulatstabilizĆ”lĆ³ gyĆ³gyszerek (lĆ­tium, valproinsav, karbamazepin) hatĆ”sai a kalcium ionok Ć”ltal kƶzvetĆ­tett intracellulĆ”ris jelĆ”tvitelre = Effects of mood stabilizer drugs (lithium, valproic acid, carbamazepine) on the calcium ion mediated intracellular signal transduction. Project Report. OTKA. Sipos, Katalin and Debreceni, BalĆ”zs and MĆ³zsik, Gyula (2010) A hepcidin, egy mĆ”j Ć”ltal termelt hormon szerepe a ...
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Effects of Mixture of Pharmaceuticals on Early Life Stages of Tench (Tinca tinca)Effects of Mixture of Pharmaceuticals on Early Life Stages of Tench (Tinca tinca)
Ubiquitous occurrence of pharmaceuticals in aquatic environment results in concern about potential adverse the effects on nontarget organisms. In water, drugs are present in complex mixtures, in which complicated interactions affect toxicity of single components. The purpose of this study was to examine effect of 35-day-long exposure to mixture of ibuprofen, diclofenac, and carbamazepine on the mortality, growth, early ontogeny, and histopathological changes in tench (|i|Tinca tinca|/i|). Early life stage toxicity test was carried out using a modified protocol according to OECD guideline 210. Exposure to mixture of pharmaceuticals at concentration of 60 |i|μ|/i|g·L|sup|−1|/sup| for each substance was associated with significant increase in mortality, as well as significant increase in growth and elevated incidence of malformations. Any of the tested concentrations resulted in histopathological changes of liver, kidney, skin, or gill. After fourteen days of exposure there was
https://www.hindawi.com/journals/bmri/2014/253468/
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Comparative safety of antiepileptic drugs for neurological development in children exposed during pregnancy and breast feeding:...Comparative safety of antiepileptic drugs for neurological development in children exposed during pregnancy and breast feeding:...
Our results suggest that AEDs generally pose a risk for infants and children exposed in utero or during breast feeding. Valproate was significantly associated with more children experiencing autism/dyspraxia, language, cognitive and psychomotor developmental delays versus children who were not exposed to AEDs. Oxcarbazepine, lamotrigine and lamotrigine+valproate were associated with increased occurrence of autism/dyspraxia, whereas for the cognitive developmental delay and psychomotor developmental delay outcomes, children exposed to the combination of carbamazepine, phenobarbital and valproate were at greater odds of harm than those who were not exposed to AEDs. However, these results should be interpreted with caution, as a number of factors (eg, anticonvulsant dosing, severity of epilepsy, duration of exposure, serum concentrations of exposure, mothers IQ/education) that may all influence outcomes were not identified in these studies. Also, our subsequent analyses may be underpowered due to ...
http://bmjopen.bmj.com/content/7/7/e017248
Bipolar Disorder Treatment - Valproate and CarbamazepineBipolar Disorder Treatment - Valproate and Carbamazepine
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Choice of parametric models in survival analysis: applications to monotherapy for epilepsy and cerebral palsy - WRAP: Warwick...Choice of parametric models in survival analysis: applications to monotherapy for epilepsy and cerebral palsy - WRAP: Warwick...
In the analysis of medical survival data, semiparametric proportional hazards models are widely used. When the proportional hazards assumption is not tenable, these models will not be suitable. Other models for covariate effects can be useful. In particular, we consider accelerated life models, in which the effect of covariates is to scale the quantiles of the base-line distribution. Solomon and Hutton have suggested that there is some robustness to misspecification of survival regression models. They showed that the relative importance of covariates is preserved under misspecification with assumptions of small coefficients and orthogonal transformation of covariates. We elucidate these results by applications to data from five trials which compare two common anti-epileptic drugs (carbamazepine versus sodium valporate monotherapy for epilepsy) and to survival of a cohort of people with cerebral palsy. Results on the robustness against model misspecification depend on the assumptions of small ...
http://wrap.warwick.ac.uk/9830/
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CYP3A4-Mediated Carbamazepine (CBZ) Metabolism: Formation of a Covalent CBZ-CYP3A4 Adduct and Alteration of the Enzyme Kinetic...
PubMed Central Canada (PMC Canada) provides free access to a stable and permanent online digital archive of full-text, peer-reviewed health and life sciences research publications. It builds on PubMed Central (PMC), the U.S. National Institutes of Health (NIH) free digital archive of biomedical and life sciences journal literature and is a member of the broader PMC International (PMCI) network of e-repositories.
http://pubmedcentralcanada.ca/pmcc/articles/PMC2881839/
RePub, Erasmus University Repository: Anti-epileptic drug regimens and major congenital abnormalities in the offspringRePub, Erasmus University Repository: Anti-epileptic drug regimens and major congenital abnormalities in the offspring
To assess the risk of major congenital abnormalities associated with specific antiepileptic drug regimens, a large retrospective cohort study was performed. The study comprised 1,411 children born between 1972 and 1992 in four provinces in The Netherlands who were born to mothers with epilepsy and using antiepileptic drugs during the first trimester of pregnancy, and 2,000 nonepileptic matched controls. We found significantly increased risks of major congenital abnormalities for carbamazepine and valproate monotherapy, with evidence for a significant dose-response relationship for valproate. The risk of major congenital abnormalities was nonsignificantly increased for phenobarbital monotherapy when caffeine comedication was excluded, but a significant increase in risk was found when caffeine was included. Phenytoin monotherapy was not associated with an increased risk of major congenital abnormalities. Regarding polytherapy regimens, increased risks were found for several antiepileptic drug ...
https://repub.eur.nl/pub/5914
Impact of Oxidative Stress and Newer Antiepileptic Drugs on the Albumin and Cortisol Value in Severe Motor and Intellectual...Impact of Oxidative Stress and Newer Antiepileptic Drugs on the Albumin and Cortisol Value in Severe Motor and Intellectual...
Impact of Oxidative Stress and Newer Antiepileptic Drugs on the Albumin and Cortisol Value in Severe Motor and Intellectual Disabilities With Epilepsy
http://www.jocmr.org/index.php/JOCMR/article/view/3289/2034
Impact of Oxidative Stress and Newer Antiepileptic Drugs on the Albumin and Cortisol Value in Severe Motor and Intellectual...Impact of Oxidative Stress and Newer Antiepileptic Drugs on the Albumin and Cortisol Value in Severe Motor and Intellectual...
Impact of Oxidative Stress and Newer Antiepileptic Drugs on the Albumin and Cortisol Value in Severe Motor and Intellectual Disabilities With Epilepsy
http://www.jocmr.org/index.php/JOCMR/article/view/3289
Buy Carbatrol (Carbamazepine) Online
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Buy Carbatrol (Carbamazepine) Online
Buy Carbatrol Online! Carbatrol is an anticonvulsant and specific analgesic for trigeminal neuralgia, available for oral administration as chewable tablets of 100 mg, tablets of 200 mg, XR tablets of 100, 200, and 400 mg, and as a suspension of 100 mg/5 mL (teaspoon). Its molecular weight is 236.27.
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What is a treatment for trigemnial neuralgia? | Reference.comWhat is a treatment for trigemnial neuralgia? | Reference.com
Prescription medications used to reduce pain caused by trigeminal neuralgia include muscle relaxers such as baclofen and anticonvulsant drugs such as carbamazepine, oxcarbazepine and lamotrigine,...
https://www.reference.com/health/treatment-trigemnial-neuralgia-196a9abdbbf4d62a
BCRCP PharmaWave
A brief discussion of epilepsy with special reference to carbamazepine Hirak Kumar Mukhopadhyay *1,2, Chandi Charan Kandar1, Sanjoy Kumar Das 1, Lakshmikanta Ghosh 2, Bijan Kumar Gupta 2 1 Institute of Pharmacy, Jalpaiguri, P.O. + Dist. - Jalpaiguri, 735 101, W.B., India. 2 Department of Pharmaceutical Technology, Jadavpur University, Kolkata - 700 032, W.B., India. Running Title: Carbamazepine and epilepsy *Corresponding author: E-mail: [email protected] Tel: 9434491615 Fax: 03561-221884 ABSTRACT Epilepsy is becoming the most serious disorder of brain function and affects 40 million people worldwide. The prevalence rate of epilepsy is 4 to 10 per thousand population. The incidence of epilepsy is less in most developed countries than developing countries. Epilepsy can result form brain injuries caused by blows to the head, stroke, infections, high fever or tumors. Some cases of epilepsy are induced by genetic factors. Several factors are proved to be responsible for precipitating seizures in ...
http://bcrcppharmawave.net/abstract510.aspx
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ENHANCEMENT OF CARBAMZEPINE SOLUBILITY USING SELECTED WATER SOLUBLE PO by Sameer LateENHANCEMENT OF CARBAMZEPINE SOLUBILITY USING SELECTED WATER SOLUBLE PO by Sameer Late
With the recent advent of combinatorial chemistry and high throughput screening of potentially therapeutic agents, the number of poorly soluble drug candidate has risen sharply and the formulation of poorly soluble compounds for oral delivery now presents one of the most frequent and greatest challenge to formulation scientists in the pharmaceutical industry. There are certain drugs for which solubility has presented a challenge to the development of a suitable formulation for oral administration. And one of these drugs is carbamazepine. In the literature, solid dispersions have shown tremendous potential for improving drug solubility and dissolution. In this study the main objective was to enhance the solubility of carbamazepine using selected water-soluble polymers and a solid dispersion technique. The solid dispersions were prepared by fusion method, using water-soluble polymers as carriers, namely Solutol HS, Vitamin E TPGS, Poloxamer 188 and Lipocol C 10 at a fixed ratio of 9:1 (drug:carrier) was
http://digitalcommons.uri.edu/theses/261/
Ligand Partner Lundbeck Receives FDA Approval of Carnexivā„¢ (carbamazepine) Injection as Intravenous Short-Term Replacement...Ligand Partner Lundbeck Receives FDA Approval of Carnexivā„¢ (carbamazepine) Injection as Intravenous Short-Term Replacement...
All other trademarks or registered trademarks are the property of their respective owners. About Ligand Pharmaceuticals Ligand is a biopharmaceutical company focused on developing or acquiring technologies that help pharmaceutical companies discover and develop medicines. Our business model creates value for stockholders by providing a diversified portfolio of biotech and pharmaceutical product revenue streams that are supported by an efficient and low corporate cost structure. Our goal is to offer investors an opportunity to participate in the promise of the biotech industry in a profitable, diversified and lower-risk business than a typical biotech company. Our business model is based on doing what we do best: drug discovery, early-stage drug development, product reformulation and partnering. We partner with other pharmaceutical companies to leverage what they do best (late-stage development, regulatory management and commercialization) to ultimately generate our revenue. Ligands CaptisolĀ® ...
https://www.ligand.com/news-events/press-releases/detail/304/ligand-partner-lundbeck-receives-fda-approval-of
CarbamazepineCarbamazepine
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Management of multiple sclerosisManagement of multiple sclerosis
Certain medications for MS symptoms, such as carbamazepine (used to treat spasms and pain) and modafinil (used to treat fatigue ... "Carbamazepine". MedlinePlus. 19 March 2020. Retrieved 28 March 2020. "Phenytoin". MedlinePlus. 19 March 2020. Retrieved 28 ... Acute pain due to trigeminal neuralgia is usually successfully treated with anticonvulsants such as carbamazepine or phenytoin ... Both Lhermitte's sign and painful dysesthesias usually respond to treatment with carbamazepine, clonazepam, or amitriptyline. ...
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Follicular hyperplasiaFollicular hyperplasia
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List of allergensList of allergens
"Carbamazepine". Nemours KidsHealth. Archived from the original on November 4, 2011. Kelkar PS, Li JT (September 2001). " ... "Trileptal" (PDF). Marshall H (2 September 2017). "Carbamazepine (Tegretol, Carbagen): uses, dosage, side effects, warnings". ...
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Brazilian Controlled Drugs and Substances ActBrazilian Controlled Drugs and Substances Act
CARBAMAZEPINE 20. CAROXAZONE 21. CETAMINE 22. CYCLARBAMATE 23. CICLEXEDRINE 24. CYCLOPENTOLATE 25. CITALOPRAM 26. CLOMACRANE 27 ...
https://en.wikipedia.org/wiki/Brazilian_Controlled_Drugs_and_Substances_Act
Fibre supplementsFibre supplements
Ettinger AB, Shinnar S, Sinnett MJ, Moshe SL (1992). "Carbamazepine-induced constipation". J Epilepsy. 5 (3): 191-193. doi: ... For example, antidepressant medications, diabetes medications, carbamazepine, cholesterol-lowering medications and penicillin. ...
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Ahmed OkashaAhmed Okasha
Carbamazepine versus alprazolam. An augmenting therapy for resistant schizophrenia. Read at the Regional WPA Symposium, ...
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Attention deficit hyperactivity disorder managementAttention deficit hyperactivity disorder management
"carbamazepine (Rx) - Tegretol, Equetro". Medscape Drugs & Diseases. Silva, RR; Munoz, DM; Alpert, M (March 1996). " ... "Carbamazepine Use in Children and Adolescents with Features of Attention-Deficit Hyperactivity Disorder: A Meta-Analysis". ...
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Panayiotopoulos syndromePanayiotopoulos syndrome
Treatment with carbamazepine was initiated. After 6 months, she had a third episode similar to the previous ones, but shorter. ... Carbamazepine was replaced with phenobarbital. All 12 interictal EEGs during the active seizure period, 6 of them during sleep ...
https://en.wikipedia.org/wiki/Panayiotopoulos_syndrome
Hallucinatory palinopsiaHallucinatory palinopsia
Silva, JA; Tekell, JL; Penny, G; Bowden, CL (Jan 1997). "Resolution of palinopsia with carbamazepine". The Journal of Clinical ...
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RemacemideRemacemide
Ramacemide does interact with carbamazepine. Remacemide inhibits the metabolism of carbamazepine, while carbamazepine induces ... Wesnes KA, Edgar C, Dean AD, Wroe SJ (March 2009). "The cognitive and psychomotor effects of remacemide and carbamazepine in ... January 2002). "A comparative study of the effects of carbamazepine and the NMDA receptor antagonist remacemide on road ... "Mutual interaction between remacemide hydrochloride and carbamazepine: two drugs with active metabolites". Epilepsia. 37 (11): ...
https://en.wikipedia.org/wiki/Remacemide
Hemifacial spasmHemifacial spasm
Alexander GE, Moses H (1982). "Carbamazepine for hemi facial spasm". Neurology. 32 (3): 286-287. doi:10.1212/wnl.32.3.286. PMID ... Mild cases of hemifacial spasm may be managed with sedation or carbamazepine (an anticonvulsant drug). Microsurgical ...
https://en.wikipedia.org/wiki/Hemifacial_spasm
DepressantDepressant
... carbamazepine, lamotrigine, etc.) Antihistamines (diphenhydramine, doxylamine, promethazine, etc.) Antipsychotics (haloperidol ...
https://en.wikipedia.org/wiki/Depressant
John McGinnessJohn McGinness
Avoiding neurotoxicity with lithium-carbamazepine combinations. Psychopharmacol Bull. 1990;26(2):181-4. McGinness JE, Grossie B ...
https://en.wikipedia.org/wiki/John_McGinness
ClonazepamClonazepam
... decreases the levels of carbamazepine, and, likewise, clonazepam's level is reduced by carbamazepine. Azole ... Carbamazepine has been tested in the treatment of clonazepam withdrawal but was found to be ineffective in preventing ... Anders RJ, Wang E, Radhakrishnan J, Sharifi R, Lee M (October 1985). "Overflow urinary incontinence due to carbamazepine". The ... Sechi GP, Zoroddu G, Rosati G (September 1984). "Failure of carbamazepine to prevent clonazepam withdrawal status epilepticus ...
https://en.wikipedia.org/wiki/Clonazepam
PetasitesPetasites
John's wort, carbamazepine, phenytoin, rifampin); this interaction can potentially lead to increased concentration of the toxic ...
https://en.wikipedia.org/wiki/Petasites
IsoniazidIsoniazid
People taking carbamazepine should have their carbamazepine levels monitored and, if necessary, have their dose adjusted ... Fleenor, M.E.; Harden, J.W.; Curtis, G. (June 1991). "Interaction between carbamazepine and antituberculosis agents". Chest. 99 ... Isoniazid decreases the metabolism of carbamazepine, thus slowing down its clearance from the body. ...
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AnticonvulsantAnticonvulsant
On the other hand, evidence is conflicting for carbamazepine regarding any increased risk of congenital physical anomalies or ... Oxcarbazepine (1990). A derivative of carbamazepine that has similar efficacy and is better tolerated and is also available ... On the other hand, valproate, phenobarbital, phenytoin, and carbamazepine probably are not transferred into breast milk in ... Many of the common used medications, such as valproate, phenytoin, carbamazepine, phenobarbitol, gabapentin have been reported ...
https://en.wikipedia.org/wiki/Anticonvulsant
AntidiureticAntidiuretic
Miscellaneous others include chlorpropamide and carbamazepine. Diuretic Electrolyte Water-electrolyte imbalance Antidiuretic+ ...
https://en.wikipedia.org/wiki/Antidiuretic
Ear painEar pain
Glossopharyngeal neuralgia is treated with carbamazepine. 2/3 of people presenting with ear pain were diagnosed with some sort ...
https://en.wikipedia.org/wiki/Ear_pain
PrimidonePrimidone
Compared to carbamazepine, lamotrigine, and phenytoin, this is very low. The rate is comparable to that of felbamate, ... Primidone, carbamazepine, phenobarbital and phenytoin are among the most potent hepatic enzyme inducing drugs in existence. ... Increased fracture rate has also been reported for carbamazepine, valproate and clonazepam. The risk of fractures is higher for ... Primidone is one of the anticonvulsants associated with anticonvulsant hypersensitivity syndrome, others being carbamazepine, ...
https://en.wikipedia.org/wiki/Primidone
Drug reaction with eosinophilia and systemic symptomsDrug reaction with eosinophilia and systemic symptoms
2008). "Carbamazepine-induced drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome: report of four cases and ... Japanese expressing the serotypes HLA-A11 or HLA-B51 also have increased risks of developing it in response to Carbamazepine. ... Sep-Oct 2004). "DRESS syndrome associated with carbamazepine and phenytoin". European Journal of Dermatology. 14 (5): 339-342. ... These associations include the following: Carbamazepine: Chinese, Koreans, Japanese, and European individuals who express the ...
https://en.wikipedia.org/wiki/Drug_reaction_with_eosinophilia_and_systemic_symptoms
OxitriptylineOxitriptyline
Carbamazepine Eslicarbazepine Oxcarbazepine Benzocycloheptenes Triggle DJ (1997). Dictionary of pharmacological agents. London ...
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Borderline personality disorderBorderline personality disorder
The effect of carbamazepine was not significant. Of the antidepressants, amitriptyline may reduce depression, but mianserin, ...
https://en.wikipedia.org/wiki/Borderline_personality_disorder
BupropionBupropion
Indeed, carbamazepine decreases exposure to bupropion by 90% and increases exposure to hydroxybupropion by 94%. Ritonavir, ... October 1995). "Carbamazepine but not valproate induces bupropion metabolism". Journal of Clinical Psychopharmacology. 15 (5): ... can be expected with CYP2B6 inducers such as carbamazepine, clotrimazole, rifampicin, ritonavir, St John's wort, and ...
https://en.wikipedia.org/wiki/Bupropion
PhenytoinPhenytoin
Trigeminal neuralgia: Second choice drug to carbamazepine. Phenytoin has a narrow therapeutic index. Its therapeutic range for ... consideration should be given to avoiding phenytoin as an alternative to carbamazepine in patients carrying this allele. ... that since strong evidence exists linking HLA-B*1502 with the risk of developing SJS or TEN in patients taking carbamazepine, ...
https://en.wikipedia.org/wiki/Phenytoin
Cytochrome P450Cytochrome P450
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ClarithromycinClarithromycin
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Trigeminal neuralgiaTrigeminal neuralgia
The anticonvulsant carbamazepine or oxcarbazepine is usually the initial treatment, and is effective in about 90% of people. ... The anticonvulsant carbamazepine is the first line treatment; second line medications include baclofen, lamotrigine, ...
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VigabatrinVigabatrin
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Carbamazepine: MedlinePlus Drug InformationCarbamazepine: MedlinePlus Drug Information
Carbamazepine: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Continue to take carbamazepine even if you feel well. Do not stop taking carbamazepine without talking to your doctor, even if ... Carbamazepine may harm the fetus. If you become pregnant while taking carbamazepine, call your doctor immediately. ... Your doctor will probably tell you not to take carbamazepine. If you stop taking carbamazepine, you should wait at least 14 ...
https://medlineplus.gov/druginfo/meds/a682237.html
Trigeminal Neuralgia Treatment & Management: Approach Considerations, Overview of Antiepileptic Drugs, Carbamazepine TherapyTrigeminal Neuralgia Treatment & Management: Approach Considerations, Overview of Antiepileptic Drugs, Carbamazepine Therapy
Carbamazepine Therapy. Carbamazepine and oxcarbazepine are considered first-line therapy in trigeminal neuralgia (TN). [29, 30 ... Generic carbamazepine is the cheapest; costs vary widely for the other agents, depending on the source, but approach a 4-fold ... 15] According to Parekh et al and Raskin, the dose of carbamazepine then may be reduced to 500 mg/d to maintain a putative ... Since the carbamazepine studies, however, newer second- and third-generation AEDs have expanded the choice of AED in trigeminal ...
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Carbamazepine: Seizure Medication Side Effects & DosageCarbamazepine: Seizure Medication Side Effects & Dosage
... carbamazepine) injection is an anticonvulsant used to treat partial seizures, generalized tonic-clonic seizures, mixed seizure ... Table 5: Effects of Carbamazepine on Other Drugs. Concomitant Drug Name. Effect of Carbamazepine on Other Drugs. Clinical ... Table 6: Effects of Carbamazepine on Other Drugs (Continued). Concomitant Drug Name. Effect of Carbamazepine on Other Drugs. ... Table 7: Effects of Other Drugs on Carbamazepine. Concomitant Drug Name. Effect of Concomitant Drug on Carbamazepine. Clinical ...
https://www.medicinenet.com/carnexiv_carbamazepine_injection/article.htm
Browsing by Subject CarbamazepineBrowsing by Subject "Carbamazepine"
JavaScript is disabled for your browser. Some features of this site may not work without it ...
https://extranet.who.int/iris/restricted/browse?authority=Carbamazepine&type=mesh
DailyMed - CARBAMAZEPINE tabletDailyMed - CARBAMAZEPINE tablet
When carbamazepine is given with drugs that can increase or decrease carbamazepine levels, close monitoring of carbamazepine ... Carbamazepine is more rapidly metabolized to carbamazepine-10, 11-epoxide (a metabolite shown to be equipotent to carbamazepine ... Do not take carbamazepine if you: ā€¢ have a history of bone marrow depression. ā€¢ are allergic to carbamazepine or any of the ... The effect of carbamazepine on human labor and delivery is unknown. Nursing Mothers Carbamazepine and its epoxide metabolite ...
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Carbamazepine (Oral Route) Proper Use - Mayo ClinicCarbamazepine (Oral Route) Proper Use - Mayo Clinic
Carbamazepine is not an ordinary pain reliever. It should be used only when a doctor prescribes it for certain kinds of pain. ... Do not take carbamazepine together with a monoamine oxidase inhibitor (MAOI) or during the first 14 days after you stop taking ... Carbamazepine is used to treat certain types of seizures (epilepsy). It is also used to relieve pain due to trigeminal ... Carbamazepine EquetroĀ® extended-release capsules do not need to be taken with meals unless they upset your stomach. The ...
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Risk of serious cutaneous disorders after initiation of use of phenytoin, carbamazepine, or sodium valproate: A record linkage...Risk of serious cutaneous disorders after initiation of use of phenytoin, carbamazepine, or sodium valproate: A record linkage...
The objective of this study was to measure risk of serious cutaneous reactions in new users of phenytoin, carbamazepine, or ... During the first few weeks of initiating therapy with phenytoin or carbamazepine, the clinician should be aware of the uncommon ... There were six serious cutaneous reactions in 9,738 new carbamazepine users. These included one probable case and four possible ... Risk of serious cutaneous disorders after initiation of use of phenytoin, carbamazepine, or sodium valproate: A record linkage ...
https://www.rti.org/publication/risk-serious-cutaneous-disorders-after-initiation-use-phenytoin-carbamazepine-or-sodium
Porphyria cutanea tarda associated with carbamazepine treatmentPorphyria cutanea tarda associated with carbamazepine treatment
... Am J Psychiatry. 1996 Mar;153(3):443-4. doi: 10.1176/ajp.153.3. ...
https://pubmed.ncbi.nlm.nih.gov/8610843/
Pms Carbamazepine - UniprixPms Carbamazepine - Uniprix
PMS CARBAMAZEPINE, 100MG, CHEWABLE TAB. Common uses. This medication is typically used for bipolar disorder (manic-depressive ...
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Carbamazepine Toxicity Treatment & Management: Prehospital Care, Emergency Department Care, Medical CareCarbamazepine Toxicity Treatment & Management: Prehospital Care, Emergency Department Care, Medical Care
Carbamazepine (5H-dibenzazepine-5-carboxamide) is an iminostilbene derivative with a tricyclic structure. It is an ... Severity and carbamazepine level at time of initial poison center contact correlate with outcome in carbamazepine poisoning. J ... An exception to decreasing the carbamazepine level to a subtherapeutic level is in the patient who is taking carbamazepine for ... encoded search term (Carbamazepine Toxicity) and Carbamazepine Toxicity What to Read Next on Medscape ...
https://emedicine.medscape.com/article/813654-treatment
Sandoz Carbamazepine - Uses, Side Effects, Interactions - MedBroadcast.comSandoz Carbamazepine - Uses, Side Effects, Interactions - MedBroadcast.com
Carbamazepine is used to manage certain types of seizures, alone or in combination with other medications. It is also used to ... If you are a breast-feeding mother and are taking carbamazepine, it may affect your baby. If a mother taking carbamazepine ... 02261847 Sandoz Carbamazepine CR 400 mg Tablet (controlled release). 02261839 Sandoz Carbamazepine CR 200 mg Tablet (controlled ... Drowsiness/reduced alertness: Carbamazepine may cause dizziness and drowsiness. People taking carbamazepine should avoid ...
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Carbamazepine - Dosage and How to useCarbamazepine - Dosage and How to use
Carbamazepine should be taken as prescribed by your doctor. You may take this medication after food. ... Carbamazepine - Dosage and How to Use. How should Carbamazepine be used?. *Follow the instructions on your medication label and ...
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Carbamazepine (Tegretol) Prices - U.S. & International | PharmacyChecker.comCarbamazepine (Tegretol) Prices - U.S. & International | PharmacyChecker.com
Free coupons for carbamazepine (tegretol). Discounts up to 80% off the retail price. ... Compare Carbamazepine (tegretol) 200 mg prices from verified online pharmacies or local U.S. pharmacies. ... Carbamazepine Chewable, Carbamazepine CR, Tegretol , Tegretol Chewable, Tegretol Retard, Tegretol XR, Tegrital ... Carbamazepine Prices - (Tegretol) Compare Carbamazepine (Tegretol) prices available at Canadian and international online ...
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Comparison of the efficacy of carbamazepine, gabapentin and lamotrigine for neuropathic pain in rats Chogtu B, Bairy K L,...Comparison of the efficacy of carbamazepine, gabapentin and lamotrigine for neuropathic pain in rats Chogtu B, Bairy K L,...
Carbamazepine (100 mg/kg), [6] gabapentin (60 mg/kg), [7] lamotrigine (40 mg/kg) [8] were used in the doses as per the previous ... Carbamazepine conquers spinal GAP43 deficiency and sciatic Nav1.5 upregulation in diabetic mice: novel mechanisms in ... Keywords: Carbamazepine, gabapentin, lamotrigine, paclitaxel induced neuropathic pain. How to cite this article:. Chogtu B, ... Values are in mean Ā± Standard error (SE) (n = 6); lam = lamotrigine, gbp = gabapentin, cbz = carbamazepine. Click here to view ...
https://www.ijp-online.com/article.asp?issn=0253-7613
Metabolism of carbamazepine. | Drug Metabolism & DispositionMetabolism of carbamazepine. | Drug Metabolism & Disposition
Thirty-two metabolites of carbamazepine, in addition to the 10,11-epoxide, have been isolated from enzymatically hydrolyzed ... support the hypothesis that multiple epoxides and a cyclic peroxide are involved in the in vivo metabolism of carbamazepine by ...
https://dmd.aspetjournals.org/content/10/1/1?ijkey=bfcea029a286709b12f03ae07edae69857b17051&keytype2=tf_ipsecsha
Carbamazepine - Handling and StorageCarbamazepine - Handling and Storage
Carbamazepine should be kept in a cool, dry place, away from direct sunlight. Keep away from children. ... Carbamazepine - Handling. How should I handle Carbamazepine safely?. Carbamazepine - Storage. How should I store Carbamazepine ... How should I dispose of Carbamazepine safely?. ā€‹Pack this medication into a black trash bag and seal it tightly before throwing ...
https://www.singhealth.com.sg/patient-care/medicine/carbamazepine/handling
CARTF - Overview: Carbamazepine Profile, SerumCARTF - Overview: Carbamazepine Profile, Serum
Free carbamazepine concentration may also be useful to monitor in patients with altered or unpredictable protein binding ... Monitoring patients exhibiting symptoms of carbamazepine toxicity whose total serum carbamazepine concentration is within the ... Free carbamazepine is isolated from serum by ultrafiltration.. CARTA: The ONLINE TDM Carbamazepine Gen.4 assay is a homogeneous ... Carbamazepine, Total:. CARTA: The ONLINE TDM Carbamazepine Gen.4 assay is a homogeneous microparticle agglutination immunoassay ...
https://www.mayocliniclabs.com/test-catalog/overview/37037
Possibly Fatal Skin Reactions to Carbamazepine - Cabatrol, Tegretol, Equertro - US Recall NewsPossibly Fatal Skin Reactions to Carbamazepine - Cabatrol, Tegretol, Equertro - US Recall News
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https://www.semanticscholar.org/paper/Carbamazepine-Does-Not-Alter-Biochemical-Parameters-Br%C3%A4mswig-Zittermann/52c978ae42ba054600728cdb66a892fbfa96af86
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Lamotrigine, phenytoin and carbamazepine interactions on the sodium current present in N4TG1 mouse neuroblastoma cells. |...Lamotrigine, phenytoin and carbamazepine interactions on the sodium current present in N4TG1 mouse neuroblastoma cells. |...
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Serum monitoring of carbamazepine in patients with epilepsy and clinical implications<...
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Sertraline-induced potentiation of the CYP3A4-dependent neurotoxicity of carbamazepine: an in vitro study. | Scholars@DukeSertraline-induced potentiation of the CYP3A4-dependent neurotoxicity of carbamazepine: an in vitro study. | [email protected]
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PhenobarbitalTegretol xr vs carbamazepineEpilepsyEffects of CarbamazepineTrigeminalDrugsCarbatrolSeizuresTabletInteractionsOxcarbazepineToxicityAnticonvulsantsUses of carbamazepinePhenytoin or carbamazepineDosageMedicationOral carbamazepineDoseValproicSerumMetabolismPost-tetanic potentiationLamotrigineMonotherapyToxic epidermalAntiepileptic drugGenericBipolar2021PrescriptionMechanismPharmacyPotentiationPharmacie en ligneEpoxidePotent inducerReactionsGabapentinDosesTreatmentTherapeuticDecreaseClinicalPatientsPregnancy
Phenobarbital2
  • Neuropsychological effects in children exposed to anticonvulsant monotherapy during gestation: Phenobarbital, carbamazepine, and phenytoin. (bvsalud.org)
  • Usage during pregnancy of the antiseizure medication (ASM), phenobarbital (PB), carbamazepine (CBZ), and phenytoin (PHT), has been associated with adverse pregnancy outcomes . (bvsalud.org)
Tegretol xr vs carbamazepine20
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Epilepsy11
  • Carbamazepine is used alone or in combination with other medications to control certain types of seizures in people with epilepsy. (medlineplus.gov)
  • Carbamazepine is used to treat certain types of seizures (epilepsy). (mayoclinic.org)
  • Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of carbamazepine to treat epilepsy in children. (mayoclinic.org)
  • Carbamazepine is indicated for the treatment of epilepsy and pain associated with true trigeminal neuralgia. (drugbank.com)
  • Carbamazepine is a prescription medication used to treat epilepsy and trigeminal neuralgia (a condition that causes facial nerve pain). (rxwiki.com)
  • Our study aimed to monitor the serum level and determine the concentration/dose relationship of carbamazepine in people with epilepsy, analyzing its clinical implication. (edu.pe)
  • Antiepileptic drugs such as carbamazepine (CBZ) and selective serotonin reuptake inhibitors such as sertraline (SRT) are commonly co-prescribed to patients with epilepsy and comorbid depression. (duke.edu)
  • Tegretol (Carbamazepine) is an anticonvulsant drug that is prescribed to treat the symptoms of epilepsy, trigeminal neuralgia and bipolar mania. (canadianprescriptiondrugstore.com)
  • I am writing to see if anyone has taken the epilepsy drug carbamazepine to releive their EM symptoms and pain. (livingwitherythromelalgia.org)
  • Vigabatrin versus carbamazepine monotherapy for epilepsy. (druglib.com)
  • Whether VGB monotherapy is an effective and safe treatment compared with the standard antiepileptic drug carbamazepine (CBZ) monotherapy for epilepsy has not been systematically reviewed. (druglib.com)
Effects of Carbamazepine2
  • Although appropriate studies on the relationship of age to the effects of carbamazepine have not been performed in the geriatric population, geriatric-specific problems are not expected to limit the usefulness of carbamazepine in the elderly. (mayoclinic.org)
  • Hadzagic-Catibusic F, Hasanbegovic E, Melunovic M, Zubcevic S, Uzicanin S. Effects of Carbamazepine and Valproate on Serum Aspartate Aminotransferase, Alanine Aminotransferase and Gamma - Glutamyltransferase in Children. (medigraphic.com)
Trigeminal12
  • Carbamazepine Tablets, carbamazepine USP, is an anticonvulsant and specific analgesic for trigeminal neuralgia, available for oral administration as tablets of 100 mg and 200 mg. (nih.gov)
  • In controlled clinical trials, carbamazepine has been shown to be effective in the treatment of psychomotor and grand mal seizures, as well as trigeminal neuralgia. (nih.gov)
  • Antiepileptic drugs (AEDs) work well for trigeminal neuralgia (TN) and have been known to do so since a study was completed with phenytoin (PHE) in 1942 (Bergouignan) and another with carbamazepine (CBZ) in 1962 (Blom). (medscape.com)
  • [ 27 ] With 3 placebo-controlled crossover studies validating its efficacy in trigeminal neuralgia, providing relief by roughly 75% versus only 25% in the placebo arms (Killian, Nicol, Campbell), carbamazepine is the best studied drug for this disorder and the only one with US Food and Drug Administration (FDA) approval in this setting. (medscape.com)
  • Since the carbamazepine studies, however, newer second- and third-generation AEDs have expanded the choice of AED in trigeminal neuralgia, having demonstrated their efficacy in a variety of neuropathic pain syndromes, including trigeminal neuralgia, as well as in painful diabetic polyneuropathy and postherpetic neuralgia. (medscape.com)
  • The starting dose of carbamazepine for treating the pain of trigeminal neuralgia is 100 mg taken twice daily. (medbroadcast.com)
  • Several antiepileptic drugs like carbamazepine, phenytoin, lamotrigine, felbamate are effective in neuropathic pain and trigeminal neuralgia. (ijp-online.com)
  • Carbamazepine is an anticonvulsant used to treat various types of seizures and pain resulting from trigeminal neuralgia. (drugbank.com)
  • Carbamazepine, also known as Tegretol, is an anticonvulsant drug and analgesic drug used to control seizures and to treat pain resulting from trigeminal neuralgia. (drugbank.com)
  • Carbamazepine treats seizures and the symptoms of trigeminal neuralgia by inhibiting sodium channels. (drugbank.com)
  • Carbamazepine is a prescription medicine used to treat certain types of seizures (partial, tonic-clonic, mixed), as well as certain types of nerve pain (trigeminal and glossopharyngeal neuralgia). (rxwiki.com)
  • The American Academy of Neurology published a practice parameter that concluded that carbamazepine is effective in controlling pain of patients with classic trigeminal neuralgia, and that oxcarbazepine is probably effective and may be better tolerated. (medscape.com)
Drugs7
  • Before prescribing carbamazepine, the physician should be thoroughly familiar with the details of this prescribing information, particularly regarding use with other drugs, especially those which accentuate toxicity potential. (nih.gov)
  • Consult with your doctor about this new information before taking carbamazepine drugs. (usrecallnews.com)
  • Evidence suggests that enzymeā€inducing antiepileptic drugs (AEDs) may decrease serum 25ā€hydroxyvitamin D levels and increase bone turnover and seek to determine whether these are affected by treatment with carbamazepine or oxcarbazepine. (semanticscholar.org)
  • To prevent any kind of negative interaction, make sure you inform your doctor of any drugs you are taking including non-prescription medication, OTCs, health supplements like vitamins, minerals, herbal medicine and so on which may interfere with the effect of Carbamazepine. (internationaldrugmart.com)
  • Can I take Carbamazepine along with other drugs? (internationaldrugmart.com)
  • Carbamazepine belongs to a group of drugs called anticonvulsants, which work by decreasing abnormal electrical activities in the brain that cause seizures. (rxwiki.com)
  • To characterize further the mechanism of action of lamotrigine, we have investigated the effects of this drug together with the anticonvulsant drugs phenytoin and carbamazepine on voltage-sensitive sodium channels present in N4TG1 mouse neuroblastoma clonal cells. (aspetjournals.org)
Carbatrol2
  • Generic drug Carbamazepine is considered just as safe and effective as its brand-name equivalents such as Carbatrol and Epitol. (internationaldrugmart.com)
  • Did you know that buying the generic drug Carbamazepine from IDM is much cheaper than buying the Carbatrol or Epitol brand drug? (internationaldrugmart.com)
Seizures6
  • Carbamazepine has demonstrated anticonvulsant properties in rats and mice with electrically and chemically induced seizures. (nih.gov)
  • Carbamazepine works in the brain and nervous system to control seizures, pain, and bipolar disorder. (mayoclinic.org)
  • If carbamazepine is being added to medications that are already being taken for seizures, the starting doses may be lower. (medbroadcast.com)
  • 16 In particular, carbamazepine has shown efficacy in treating mixed seizures, partial seizures with complex symptoms, and generalized tonic-clonic seizures. (drugbank.com)
  • Carbamazepine is used to prevent and treat seizures. (internationaldrugmart.com)
  • Carbamazepine acts by reducing the irregular electrical brain activity in patients with seizures and reducing the spread of seizure activity and restoring the normal balance of nerve activity in the brain. (canadianprescriptiondrugstore.com)
Tablet3
  • Carbamazepine comes as a tablet, a chewable tablet, an extended-release (long-acting) tablet, an extended-release capsule, and as a suspension (liquid) to take by mouth. (medlineplus.gov)
  • Each beige-orange, oval, slightly biconvex, controlled-release tablet, engraved 'H/C' on one side, with 'S/S' on the other, fully bisected on both sides, contains 200 mg of carbamazepine. (medbroadcast.com)
  • Carbamazepine comes in the form of an immediate-release tablet, an extended-release tablet, extended-release capsules, a chewable immediate-release tablet, and an oral suspension form. (rxwiki.com)
Interactions3
  • Drug interactions might happen either when Carbamazepine is taken along with another drug or with particular foods. (internationaldrugmart.com)
  • Lamotrigine, phenytoin and carbamazepine interactions on the sodium current present in N4TG1 mouse neuroblastoma cells. (aspetjournals.org)
  • Results obtained from the three chapters, are used, alongside with the results from complimentary techniques, to investigate the facet specific interactions of copovidone solutions, with macroscopic single crystals of p-monoclinic carbamazepine. (bl.uk)
Oxcarbazepine1
  • This study aimed at evaluating the effects of eslicarbazepine, carbamazepine (CBZ), oxcarbazepine (OXC) and lacosamide (LCM) on the fast and slow inactivated states of voltage-gatedsodium channels (VGSC). (simulations-plus.com)
Toxicity2
  • The patient is symptom free and the carbamazepine level has decreased to less than 4-8 mg/L. Obviously, patients with significant toxicity should be admitted and patients with life threatening or potentially life-threatening signs and/or symptoms should be admitted to an ICU. (medscape.com)
  • Garc a MP, Serrano J, Fernandez-Villalba E, Briz E, G mez I. Review of carbamazepine-induced toxicity cases at a general hospital over a period of 5 years. (medigraphic.com)
Anticonvulsants2
  • Carbamazepine is in a class of medications called anticonvulsants. (medlineplus.gov)
  • Anticonvulsants such as carbamazepine or phenytoin. (web.app)
Uses of carbamazepine1
  • 16 Some off-label, unapproved uses of carbamazepine include the treatment of alcohol withdrawal syndrome and restless leg syndrome. (drugbank.com)
Phenytoin or carbamazepine1
  • During the first few weeks of initiating therapy with phenytoin or carbamazepine, the clinician should be aware of the uncommon but not rare possibility that a cutaneous eruption could evolve into a significantly more serious reaction. (rti.org)
Dosage1
Medication6
  • Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with carbamazepine and each time you refill your prescription. (medlineplus.gov)
  • Patients may find immediate and satisfying relief with one medication, typically carbamazepine. (medscape.com)
  • When taking carbamazepine suspension, shake the medication bottle well before measuring the dose of medication. (medbroadcast.com)
  • Read the Medication Guide provided by your pharmacist before you start taking carbamazepine and each time you get a refill. (healthwarehouse.com)
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  • Also mention if you have any allergies to Carbamazepine or any other ingredients included in the manufacture of this medication. (canadianprescriptiondrugstore.com)
Oral carbamazepine5
  • Carnexiv is a replacement therapy for oral carbamazepine. (medicinenet.com)
  • Carbamazepine treatment should generally be initiated with an oral carbamazepine formulation. (medicinenet.com)
  • The total daily dose of Carnexiv is 70% of the total daily oral carbamazepine dose from which patients are being switched (see Table 1). (medicinenet.com)
  • Patients should be switched back to oral carbamazepine administration at their previous total daily oral dose and frequency of administration as soon as clinically appropriate. (medicinenet.com)
  • Group I was treated with oral carbamazepine (cbz) 100 mg/kg, group II received oral gabapentin (gbp) 60 mg/kg, and group III was treated with oral lamotrigine (lam) 40 mg/kg and group IV was the control group. (ijp-online.com)
Dose6
  • Your doctor will start you on a low dose of carbamazepine and gradually increase your dose. (medlineplus.gov)
  • However, elderly patients are more likely to have confusion or agitation, which may require caution and an adjustment in the dose for patients receiving carbamazepine. (mayoclinic.org)
  • The bioavailability of carbamazepine is in the range of 75-85% of an ingested dose. (drugbank.com)
  • 3 After one 200 mg oral extended-release dose of carbamazepine in a pharmacokinetic study, the Cmax carbamazepine was measured to be 1.9 Ā± 0.3 mcg/mL. (drugbank.com)
  • It is concluded that there is a positive and significant linear correlation between daily doses and serum carbamazepine concentrations, which should be considered to individualize the dose and optimize clinical results. (edu.pe)
  • [ 104 ] In several animal reproductive studies, the use of carbamazepine at doses higher than the recommended dose in humans has been associated with teratogenic effects in rats and mice. (medscape.com)
Valproic2
  • The objective of this study was to measure risk of serious cutaneous reactions in new users of phenytoin, carbamazepine, or valproic acid. (rti.org)
  • Epidemiology of bipolar disorders -- Classification of bipolar disorders -- How to define a mood stabilizer -- Lithium -- Carbamazepine -- Lamotrigine -- Topiramate -- Valproic acid -- The role of atypical or second generation antipsychotics -- Other medications used for bipolar disorders -- Medications that may potentially induce a depressive state -- Medications that may potentially induce a (hypo)manic syndrome -- Maintenance treatment: when should a long-term treatment be introduced? (who.int)
Serum3
  • These patients may be discharged with a therapeutic serum level of carbamazepine or another substituted anticonvulsant. (medscape.com)
  • Evidence indicates that carbamazepine crosses the placenta and its concentration in cord blood equals that in maternal serum. (medscape.com)
  • The serum concentration of Triglu-5-formyl-tetrahydrofolate can be decreased when it is combined with Carbamazepine. (drugbank.com)
Metabolism10
  • Carbamazepine is a potent inducer of hepatic CYP1A2, 2B6, 2C9/19 and 3A4 and may reduce plasma concentrations of concomitant medications mainly metabolized by CYP1A2, 2B6, 2C9/19, and 3A4 through induction of their metabolism (see Tables 5 and 6). (medicinenet.com)
  • Metabolism of carbamazepine. (aspetjournals.org)
  • All of the metabolites were formed by processes involving epoxidation and a peroxidation, the structures of the metabolites support the hypothesis that multiple epoxides and a cyclic peroxide are involved in the in vivo metabolism of carbamazepine by the rat and man. (aspetjournals.org)
  • It is still not completely clear whether or not carbamazepine (CBZ) causes alterations in vitamin D status and in bone metabolism. (semanticscholar.org)
  • The medicines listed above may inhibit the metabolism of carbamazepine, thereby increasing the levels of carbamazepine in your body. (rxwiki.com)
  • There are other medicines that may increase the rate of metabolism of carbamazepine, thereby decreasing the amount of carbamazepine available in your body. (rxwiki.com)
  • CarBAMazepine: Isoniazid may decrease the metabolism of CarBAMazepine. (genericpedia.com)
  • carbamazepine will decrease the level or effect of felodipine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. (medscape.com)
  • turmeric will increase the level or effect of carbamazepine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. (medscape.com)
  • Monitor Closely (1) turmeric will increase the level or effect of carbamazepine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. (medscape.com)
Post-tetanic potentiation1
  • Animal research studies have demonstrated that carbamazepine exerts its effects by lowering polysynaptic nerve response and inhibiting post-tetanic potentiation. (drugbank.com)
Lamotrigine3
  • With this background, a study has been undertaken to compare the efficacy of antiepileptics carbamazepine (cbz), gabapentin (gbp) and lamotrigine (lam) in neuropathic pain induced by anticancer drug (paclitaxel) in rats. (ijp-online.com)
  • Lamotrigine, phenytoin and carbamazepine produced a tonic inhibition of sodium channels with IC50 values of 91, 58 and 140 microM, respectively. (aspetjournals.org)
  • Our data show that lamotrigine inhibits sodium channels in a manner that is similar to that produced by phenytoin and carbamazepine. (aspetjournals.org)
Monotherapy1
  • This was confirmed by similar findings in a study of 35 children of women exposed to carbamazepine monotherapy during gestation. (medscape.com)
Toxic epidermal5
  • Carbamazepine may cause life-threatening allergic reactions called Stevens-Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN). (medlineplus.gov)
  • Stevens-Johnson syndrome or toxic epidermal necrolysis usually occurs during the first few months of treatment with carbamazepine. (medlineplus.gov)
  • Serious and sometimes fatal dermatologic reactions, including toxic epidermal necrolysis (TEN) and Stevens-Johnson syndrome (SJS), have occurred in patients treated with carbamazepine. (medicinenet.com)
  • In studies of Han Chinese ancestry patients, a pronounced association between the HLA-B*1502 genotype and Steven Johnson syndrome and/or toxic epidermal necrolysis (SJS/TEN) resulting from carbamazepine use was observed. (drugbank.com)
  • Serious adverse reactions of carbamazepine include life-threatening skin disorders such as Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN). (rxwiki.com)
Antiepileptic drug1
Generic6
  • The FDA has alerted healthcare professionals about dangerous and possibly fatal skin reactions to Carbamazepine, marketed as Cabatrol, Tegretol, Equertro and various generic names. (usrecallnews.com)
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Bipolar5
  • 16 Interestingly, carbamazepine was the first anticonvulsant used to treat individuals with bipolar disorder. (drugbank.com)
  • 3 , 16 Carbamazepine is also indicated for the treatment of manic episodes and mixed manic-depressive episodes caused by bipolar I disorder. (drugbank.com)
  • In bipolar 1 disorder, carbamazepine has been found to decrease mania symptoms in a clinically significant manner according to the Young Mania Rating Scale (YMRS). (drugbank.com)
  • Carbamazepine treats bipolar disorder and seizure disorders. (rxwiki.com)
  • TambiĆ©n puede usarse en el tratamiento del TRASTORNO BIPOLAR, y posee propiedades analgĆ©sicas. (bvsalud.org)
20211
  • Les patients qui ont acceptĆ© de participer aprĆØs apptĆ©lĆ©phonique ont Ć©tĆ© inclus de janvier Ć  mai 2021.Les variables d'Ć©tudeĆ©taient: Ć¢ge, sexe, acuitĆ© visuelle (AV), caractĆ©ristiques de la LCET selon Diallo, pronostic fonctionnel et anatomique en post pubertĆ© (plus de 15 ans). (bvsalud.org)
Prescription22
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Mechanism1
  • In the next chapter IGC measurements are deployed, among other techniques, to investigate the mechanism of dehydration induced concomitant polymorphism of carbamazepine dihydrate. (bl.uk)
Pharmacy2
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Potentiation1
  • Sertraline-induced potentiation of the CYP3A4-dependent neurotoxicity of carbamazepine: an in vitro study. (duke.edu)
Pharmacie en ligne2
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Epoxide2
  • Thirty-two metabolites of carbamazepine, in addition to the 10,11-epoxide, have been isolated from enzymatically hydrolyzed urine by HPLC and identified by gas-chromatographic and mass-spectrometric techniques. (aspetjournals.org)
  • Carbamazepine is metabolized by the liver to carbamazepine-10,11-epoxide (CBZ10-11), which is pharmacologically active and potentially toxic. (mayocliniclabs.com)
Potent inducer1
  • Carbamazepine is principally metabolized by CYP3A4, and is a potent inducer of CYP1A2, CYP2C9, CYP3A4 and UDP-glucuronosyltransferases. (psychiatrienet.nl)
Reactions4
  • There were six serious cutaneous reactions in 9,738 new carbamazepine users. (rti.org)
  • Carbamazepine may rarely cause very serious (possibly fatal) skin reactions. (healthwarehouse.com)
  • Below is the selection of side effect reports (a.k.a. adverse event reports) related to Tegretol-XR (Carbamazepine) where reactions include dizziness. (druglib.com)
  • Genetic susceptibility to carbamazepine-induced cutaneous adverse drug reactions. (cdc.gov)
Gabapentin2
  • El uso "off-label" de los medicamentos y los escritores fantasma: ĀæcuĆ”l es el uso de gabapentin en el dolor neuropĆ”tico? (bvsalud.org)
  • INTRODUCCIƓN: El Gabapentin fue originalmente aprobado por la FDA en el aƱo 1994 para tratamento em combinaciĆ³n con otras drogas en pacientes con epilepsias refractarias. (bvsalud.org)
Doses2
  • Recommended doses of carbamazepine vary greatly, depending on the condition being treated and the age and circumstances of the person being treated. (medbroadcast.com)
  • After several doses of 800 mg every 12 hours, the peak concentrations of carbamazepine were measured to be 11.0 Ā± 2.5 mcg/mL. (drugbank.com)
Treatment6
  • Call your doctor immediately if you develop a painful rash, hives, blistering or peeling of skin, easy bruising, mouth sores, or a fever during your treatment with carbamazepine. (medlineplus.gov)
  • Your doctor will order certain lab tests before and during your treatment to check your body's response to carbamazepine. (medlineplus.gov)
  • If you test positive for HLA-B*1502 or HLA-A*3101, you should not be treated with carbamazepine unless the benefit of treatment clearly outweighs the risk of experiencing SJS or TEN. (rxwiki.com)
  • If the blood test shows you are at greater risk, discuss the risks and benefits of carbamazepine and other treatment choices with your doctor. (healthwarehouse.com)
  • Carbamazepine is regarded by most as the medical treatment of choice. (medscape.com)
  • Combination therapy with carbamazepine during gestation, particularly along with valproate, has been associated with a higher frequency of congenital anomalies than treatment with carbamazepine alone. (medscape.com)
Therapeutic2
  • 16 Carbamazepine has a narrow therapeutic index. (drugbank.com)
  • Carbamazepine is a drug with a narrow therapeutic range that requires clinical monitoring, since its toxic effects are not easily predictable, and the therapeutic level can vary. (edu.pe)
Decrease4
  • Carbamazepine may decrease the number of blood cells produced by your body. (medlineplus.gov)
  • In both cats and rats, carbamazepine was shown to decrease pain caused by infraorbital nerve stimulation. (drugbank.com)
  • A decrease in the action potential in the nucleus ventralis of the thalamus in the brain and inhibition of the lingual mandibular reflex were observed in other studies after carbamazepine use. (drugbank.com)
  • Hiilesmaa et al [ 120 ] reported a study of 133 epileptic pregnant women with matched controls, which showed that gestational carbamazepine was associated with a 10 mm decrease in fetal head circumference when compared with controls and that catch-up growth of the head was not observed by the age of 18 months. (medscape.com)
Clinical3
  • The clinician should be aware of the marginal clinical effect of extracorporal carbamazepine removal. (medscape.com)
  • Monitor carbamazepine plasma levels to make sure that they are decreasing and correlating with the clinical picture. (medscape.com)
  • The synergistic combination of carbamazepine and baclofen may provide relief from episodic pain though convincing clinical evidence is weak at best. (medscape.com)
Patients4
  • Kaneko et al [ 118 ] reported seven malformations among 45 patients treated with carbamazepine and another drug during gestation. (medscape.com)
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  • RESUME Afin d'examiner l'expĆ©rience d'une clinique de pĆ©dopsychiatrie en ce qui concerne la comorbiditĆ© et les caractĆ©ristiques du traitement des enfants souffrant d'hyperactivitĆ© avec dĆ©ficit de l'attention (HADA), une Ć©tude rĆ©trospective a Ć©tĆ© rĆ©alisĆ©e auprĆØs des patients de moins de 19 ans qui consultaient Ć  la clinique et chez lesquels un diagnostic de HADA avait Ć©tĆ© posĆ©. (who.int)
  • Il s'agit d'une Ć©tude transversale, monocentrique et descriptive, durant 12 mois, incluant les patients Ć¢gĆ©s d'au moins 18 ans admis en rĆ©animation polyvalente pour un sepsis ou choc septique. (bvsalud.org)
Pregnancy1
  • CBZ10-11 may be responsible for the congenital abnormalities that are sometimes associated with the use of carbamazepine during early pregnancy. (mayocliniclabs.com)
Metabolic Neuropathy Medication: Gastrointestinal agents, Broad-spectrum antibiotics, Cholinergic agents, Tricyclic...
Metabolic Neuropathy Medication: Gastrointestinal agents, Broad-spectrum antibiotics, Cholinergic agents, Tricyclic... (medscape.com)
Trigeminal Neuralgia in Emergency Medicine Medication: Anticonvulsants, Skeletal muscle relaxants
Trigeminal Neuralgia in Emergency Medicine Medication: Anticonvulsants, Skeletal muscle relaxants (emedicine.medscape.com)
CNS Lupus Medication: Corticosteroids, Immunosuppressants, Antimalarials, Immune Globulins, Nonsteroidal Anti-inflammatory...
CNS Lupus Medication: Corticosteroids, Immunosuppressants, Antimalarials, Immune Globulins, Nonsteroidal Anti-inflammatory... (medscape.com)
Multiple Sclerosis Medication: Immunomodulators, Corticosteroids, Immunosuppressants, Sphingosine 1-Phosphate Receptor...
Multiple Sclerosis Medication: Immunomodulators, Corticosteroids, Immunosuppressants, Sphingosine 1-Phosphate Receptor... (medscape.com)
Neurologic Manifestations of Xeroderma Pigmentosum Medication: Anticonvulsants
Neurologic Manifestations of Xeroderma Pigmentosum Medication: Anticonvulsants (emedicine.medscape.com)
Chorea in Adults Medication: Antipsychotic agents, Monoamine depleting agents, Benzodiazepines, Anticonvulsants
Chorea in Adults Medication: Antipsychotic agents, Monoamine depleting agents, Benzodiazepines, Anticonvulsants (emedicine.medscape.com)
(emedicine.medscape.com)
Tardive Dyskinesia: Overview, Pathophysiology, Etiology
Tardive Dyskinesia: Overview, Pathophysiology, Etiology (emedicine.medscape.com)
DailyMed - RISPERIDONE tablet
DailyMed - RISPERIDONE tablet (dailymed.nlm.nih.gov)
Antiepileptic Drugs: Overview, Mechanism of Action, Sodium Channel Blockers
Antiepileptic Drugs: Overview, Mechanism of Action, Sodium Channel Blockers (emedicine.medscape.com)
5 Ways to Lower the Risk of Having a Pregnancy Affected by a Neural Tube Defect | CDC
5 Ways to Lower the Risk of Having a Pregnancy Affected by a Neural Tube Defect | CDC (cdc.gov)
Mylan-Rabeprazole - Uses, Side Effects, Interactions - MedBroadcast.com
Mylan-Rabeprazole - Uses, Side Effects, Interactions - MedBroadcast.com (medbroadcast.com)
Paliperidone Injection: MedlinePlus Drug Information
Paliperidone Injection: MedlinePlus Drug Information (medlineplus.gov)
Erythroderma (Generalized Exfoliative Dermatitis) Treatment & Management: Medical Care, Consultations, Diet
Erythroderma (Generalized Exfoliative Dermatitis) Treatment & Management: Medical Care, Consultations, Diet (medscape.com)
Perioperative Medication Management: Overview, Cardiovascular System, Respiratory System
Perioperative Medication Management: Overview, Cardiovascular System, Respiratory System (medscape.com)
Clinical Practice Guidelines for Hypothyroidism in Adults
Clinical Practice Guidelines for Hypothyroidism in Adults (medscape.com)
Acute Intermittent Porphyria Clinical Presentation: History, Physical Examination
Acute Intermittent Porphyria Clinical Presentation: History, Physical Examination (medscape.com)
Guidelines on Radiation- and Chemotherapy-Induced Nausea and Vomiting: Overview, Chemotherapy-Induced Nausea and Vomiting,...
Guidelines on Radiation- and Chemotherapy-Induced Nausea and Vomiting: Overview, Chemotherapy-Induced Nausea and Vomiting,... (medscape.com)
Neuropathy secondary to drugs: MedlinePlus Medical Encyclopedia
Neuropathy secondary to drugs: MedlinePlus Medical Encyclopedia (medlineplus.gov)
Erythroderma (Generalized Exfoliative Dermatitis): Background, Pathophysiology, Etiology
Erythroderma (Generalized Exfoliative Dermatitis): Background, Pathophysiology, Etiology (medscape.com)