Carbamates: Derivatives of carbamic acid, H2NC(=O)OH. Included under this heading are N-substituted and O-substituted carbamic acids. In general carbamate esters are referred to as urethanes, and polymers that include repeating units of carbamate are referred to as POLYURETHANES. Note however that polyurethanes are derived from the polymerization of ISOCYANATES and the singular term URETHANE refers to the ethyl ester of carbamic acid.Urethane: Antineoplastic agent that is also used as a veterinary anesthetic. It has also been used as an intermediate in organic synthesis. Urethane is suspected to be a carcinogen.Propoxur: A carbamate insecticide.Insecticides: Pesticides designed to control insects that are harmful to man. The insects may be directly harmful, as those acting as disease vectors, or indirectly harmful, as destroyers of crops, food products, or textile fabrics.Carbaryl: A carbamate insecticide and parasiticide. It is a potent anticholinesterase agent belonging to the carbamate group of reversible cholinesterase inhibitors. It has a particularly low toxicity from dermal absorption and is used for control of head lice in some countries.Phosphotransferases (Carboxyl Group Acceptor): A class of enzymes that transfers phosphate groups and has a carboxyl group as an acceptor. EC 2.7.2.Carbofuran: A cholinesterase inhibitor that is used as a systemic insecticide, an acaricide, and nematocide. (From Merck Index, 11th ed)Cholinesterase Inhibitors: Drugs that inhibit cholinesterases. The neurotransmitter ACETYLCHOLINE is rapidly hydrolyzed, and thereby inactivated, by cholinesterases. When cholinesterases are inhibited, the action of endogenously released acetylcholine at cholinergic synapses is potentiated. Cholinesterase inhibitors are widely used clinically for their potentiation of cholinergic inputs to the gastrointestinal tract and urinary bladder, the eye, and skeletal muscles; they are also used for their effects on the heart and the central nervous system.Acetylcholinesterase: An enzyme that catalyzes the hydrolysis of ACETYLCHOLINE to CHOLINE and acetate. In the CNS, this enzyme plays a role in the function of peripheral neuromuscular junctions. EC 3.1.1.7.Insecticide Resistance: The development by insects of resistance to insecticides.Phenylcarbamates: Phenyl esters of carbamic acid or of N-substituted carbamic acids. Structures are similar to PHENYLUREA COMPOUNDS with a carbamate in place of the urea.Glycylglycine: The simplest of all peptides. It functions as a gamma-glutamyl acceptor.Methomyl: A carbamate insecticide with anticholinesterase activity.Pesticides: Chemicals used to destroy pests of any sort. The concept includes fungicides (FUNGICIDES, INDUSTRIAL); INSECTICIDES; RODENTICIDES; etc.Carbamyl Phosphate: The monoanhydride of carbamic acid with PHOSPHORIC ACID. It is an important intermediate metabolite and is synthesized enzymatically by CARBAMYL-PHOSPHATE SYNTHASE (AMMONIA) and CARBAMOYL-PHOSPHATE SYNTHASE (GLUTAMINE-HYDROLYZING).CholinesterasesChlorpropham: A carbamate that is used as an herbicide and as a plant growth regulator.Aldicarb: Carbamate derivative used as an insecticide, acaricide, and nematocide.Chlorphenesin: A centrally acting muscle relaxant. Its mode of action is unknown. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1203)Pesticide Residues: Pesticides or their breakdown products remaining in the environment following their normal use or accidental contamination.Organophosphate Poisoning: Poisoning due to exposure to ORGANOPHOSPHORUS COMPOUNDS, such as ORGANOPHOSPHATES; ORGANOTHIOPHOSPHATES; and ORGANOTHIOPHOSPHONATES.Pyrethrins: The active insecticidal constituent of CHRYSANTHEMUM CINERARIIFOLIUM flowers. Pyrethrin I is the pyretholone ester of chrysanthemummonocarboxylic acid and pyrethrin II is the pyretholone ester of chrysanthemumdicarboxylic acid monomethyl ester.Organophosphates: Carbon-containing phosphoric acid derivatives. Included under this heading are compounds that have CARBON atoms bound to one or more OXYGEN atoms of the P(=O)(O)3 structure. Note that several specific classes of endogenous phosphorus-containing compounds such as NUCLEOTIDES; PHOSPHOLIPIDS; and PHOSPHOPROTEINS are listed elsewhere.Butyrylcholinesterase: An aspect of cholinesterase (EC 3.1.1.8).Carboxylesterase: Carboxylesterase is a serine-dependent esterase with wide substrate specificity. The enzyme is involved in the detoxification of XENOBIOTICS and the activation of ester and of amide PRODRUGS.Houseflies: Flies of the species Musca domestica (family MUSCIDAE), which infest human habitations throughout the world and often act as carriers of pathogenic organisms.Organophosphorus Compounds: Organic compounds that contain phosphorus as an integral part of the molecule. Included under this heading is broad array of synthetic compounds that are used as PESTICIDES and DRUGS.Fungicides, Industrial: Chemicals that kill or inhibit the growth of fungi in agricultural applications, on wood, plastics, or other materials, in swimming pools, etc.Prodrugs: A compound that, on administration, must undergo chemical conversion by metabolic processes before becoming the pharmacologically active drug for which it is a prodrug.Molecular Structure: The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.Anopheles gambiae: A species of mosquito in the genus Anopheles and the principle vector of MALARIA in Africa.Fenitrothion: An organothiophosphate cholinesterase inhibitor that is used as an insecticide.Physostigmine: A cholinesterase inhibitor that is rapidly absorbed through membranes. It can be applied topically to the conjunctiva. It also can cross the blood-brain barrier and is used when central nervous system effects are desired, as in the treatment of severe anticholinergic toxicity.Mephenesin: A centrally acting muscle relaxant with a short duration of action.EstersOrnithine Carbamoyltransferase: A urea cycle enzyme that catalyzes the formation of orthophosphate and L-citrulline (CITRULLINE) from CARBAMOYL PHOSPHATE and L-ornithine (ORNITHINE). Deficiency of this enzyme may be transmitted as an X-linked trait. EC 2.1.3.3.Triallate: A pre-emergence, selective herbicide for the control of wild oats in various crops.Enzyme Reactivators: Compounds which restore enzymatic activity by removing an inhibitory group bound to the reactive site of the enzyme.Carbonates: Salts or ions of the theoretical carbonic acid, containing the radical CO2(3-). Carbonates are readily decomposed by acids. The carbonates of the alkali metals are water-soluble; all others are insoluble. (From Grant & Hackh's Chemical Dictionary, 5th ed)Carboxylic Ester Hydrolases: Enzymes which catalyze the hydrolysis of carboxylic acid esters with the formation of an alcohol and a carboxylic acid anion.DDT: A polychlorinated pesticide that is resistant to destruction by light and oxidation. Its unusual stability has resulted in difficulties in residue removal from water, soil, and foodstuffs. This substance may reasonably be anticipated to be a carcinogen: Fourth Annual Report on Carcinogens (NTP-85-002, 1985). (From Merck Index, 11th ed)Stereoisomerism: The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)Safrole: A member of the BENZODIOXOLES that is a constituent of several VOLATILE OILS, notably SASSAFRAS oil. It is a precursor in the synthesis of the insecticide PIPERONYL BUTOXIDE and the drug N-methyl-3,4-methylenedioxyamphetamine (MDMA).Anopheles: A genus of mosquitoes (CULICIDAE) that are known vectors of MALARIA.Hydrolases: Any member of the class of enzymes that catalyze the cleavage of the substrate and the addition of water to the resulting molecules, e.g., ESTERASES, glycosidases (GLYCOSIDE HYDROLASES), lipases, NUCLEOTIDASES, peptidases (PEPTIDE HYDROLASES), and phosphatases (PHOSPHORIC MONOESTER HYDROLASES). EC 3.Structure-Activity Relationship: The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.Allyl CompoundsDieldrin: An organochlorine insecticide whose use has been cancelled or suspended in the United States. It has been used to control locusts, tropical disease vectors, in termite control by direct soil injection, and non-food seed and plant treatment. (From HSDB)Biotransformation: The chemical alteration of an exogenous substance by or in a biological system. The alteration may inactivate the compound or it may result in the production of an active metabolite of an inactive parent compound. The alterations may be divided into METABOLIC DETOXICATION, PHASE I and METABOLIC DETOXICATION, PHASE II.Sulfonic Acids: Inorganic or organic oxy acids of sulfur which contain the RSO2(OH) radical.Monoacylglycerol Lipases: An enzyme that catalyzes the hydrolysis of glycerol monoesters of long-chain fatty acids EC 3.1.1.23.Aniline Mustard: Alkylating anti-neoplastic agent.Croton Oil: Viscous, nauseating oil obtained from the shrub Croton tiglium (Euphorbaceae). It is a vesicant and skin irritant used as pharmacologic standard for skin inflammation and allergy and causes skin cancer. It was formerly used as an emetic and cathartic with frequent mortality.Vinyl CompoundsCombinatorial Chemistry Techniques: A technology, in which sets of reactions for solution or solid-phase synthesis, is used to create molecular libraries for analysis of compounds on a large scale.Fumigation: The application of smoke, vapor, or gas for the purpose of disinfecting or destroying pests or microorganisms.AmidohydrolasesCarbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing): An enzyme that catalyzes the formation of carbamoyl phosphate from ATP, carbon dioxide, and glutamine. This enzyme is important in the de novo biosynthesis of pyrimidines. EC 6.3.5.5.Organothiophosphorus Compounds: Compounds containing carbon-phosphorus bonds in which the phosphorus component is also bonded to one or more sulfur atoms. Many of these compounds function as CHOLINERGIC AGENTS and as INSECTICIDES.Methanosarcina barkeri: A species of halophilic archaea whose organisms are nonmotile. Habitats include freshwater and marine mud, animal-waste lagoons, and the rumens of ungulates.Mice, Inbred AHerbicides: Pesticides used to destroy unwanted vegetation, especially various types of weeds, grasses (POACEAE), and woody plants. Some plants develop HERBICIDE RESISTANCE.Trifluoroacetic Acid: A very strong halogenated derivative of acetic acid. It is used in acid catalyzed reactions, especially those where an ester is cleaved in peptide synthesis.Mosquito Control: The reduction or regulation of the population of mosquitoes through chemical, biological, or other means.Sterol Esterase: An enzyme that catalyzes the hydrolysis of CHOLESTEROL ESTERS and some other sterol esters, to liberate cholesterol plus a fatty acid anion.Ethylene Oxide: A colorless and flammable gas at room temperature and pressure. Ethylene oxide is a bactericidal, fungicidal, and sporicidal disinfectant. It is effective against most micro-organisms, including viruses. It is used as a fumigant for foodstuffs and textiles and as an agent for the gaseous sterilization of heat-labile pharmaceutical and surgical materials. (From Reynolds, Martindale The Extra Pharmacopoeia, 30th ed, p794)Kinetics: The rate dynamics in chemical or physical systems.

Involvement of two plasmids in the degradation of carbaryl by Arthrobacter sp. strain RC100. (1/1210)

A bacterium capable of utilizing carbaryl (1-naphthyl N-methylcarbamate) as the sole carbon source was isolated from carbaryl-treated soil. This bacterium was characterized taxonomically as Arthrobacter and was designated strain RC100. RC100 hydrolyzes the N-methylcarbamate linkage to 1-naphthol, which was further metabolized via salicylate and gentisate. Strain RC100 harbored three plasmids (designated pRC1, pRC2, and pRC3). Mutants unable to degrade carbaryl arose at a high frequency after treating the culture with mitomycin C. All carbaryl-hydrolysis-deficient mutants (Cah-) lacked pRC1, and all 1-naphthol-utilization-deficient mutants (Nat-) lacked pRC2. The plasmid-free strain RC107 grew on gentisate as a carbon source. These two plasmids could be transferred to Cah- mutants or Nat- mutants by conjugation, resulting in the restoration of the Cah and Nah phenotypes.  (+info)

Efficacy and safety of rivastigmine in patients with Alzheimer's disease: international randomised controlled trial. (2/1210)

OBJECTIVES: To assess the effects of rivastigmine on the core domains of Alzheimer's disease. DESIGN: Prospective, randomised, multicentre, double blind, placebo controlled, parallel group trial. Patients received either placebo, 1-4 mg/day (lower dose) rivastigmine, or 6-12 mg/day (higher dose) rivastigmine. Doses were increased in one of two fixed dose ranges (1-4 mg/day or 6-12 mg/day) over the first 12 weeks with a subsequent assessment period of 14 weeks. SETTING: 45 centres in Europe and North America. PARTICIPANTS: 725 patients with mild to moderately severe probable Alzheimer's disease diagnosed according to the Diagnostic and Statistical Manual of Mental Disorders, fourth edition, and the criteria of the National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer's Disease and Related Disorders Association. OUTCOME MEASURES: Cognitive subscale of the Alzheimer's disease assessment scale, rating on the clinician interview based impression of change incorporating caregiver information scale, and the progressive deterioration scale. RESULTS: At the end of the study cognitive function had deteriorated among those in the placebo group. Scores on the Alzheimer's disease assessment scale improved in patients in the higher dose group when compared with patients taking placebo (P<0.05). Significantly more patients in the higher dose group had improved by 4 points or more than had improved in the placebo group (24% (57/242) v 16% (39/238)). Global function as rated by the clinician interview scale had significantly improved among those in the higher dose group compared with those taking placebo (P<0.001), and significantly more patients in the higher dose group showed improvement than did in the placebo group (37% (80/219) v 20% (46/230)). Mean scores on the progressive deterioration scale improved from baseline in patients in the higher dose group but fell in the placebo group. Adverse events were predominantly gastrointestinal, of mild to moderate severity, transient, and occurred mainly during escalation of the dose. 23% (55/242) of those in the higher dose group, 7% (18/242) of those in the lower dose group, and 7% (16/239) of those in the placebo group discontinued treatment because of adverse events. CONCLUSIONS: Rivastigmine is well tolerated and effective. It improves cognition, participation in activities of daily living, and global evaluation ratings in patients with mild to moderately severe Alzheimer's disease. This is the first treatment to show compelling evidence of efficacy in a predominantly European population.  (+info)

Treatment with amprenavir alone or amprenavir with zidovudine and lamivudine in adults with human immunodeficiency virus infection. AIDS Clinical Trials Group 347 Study Team. (3/1210)

Amprenavir is a human immunodeficiency virus (HIV) protease inhibitor with a favorable pharmacokinetic profile and good in vitro activity. Ninety-two lamivudine- and protease inhibitor-naive individuals with >/=50 CD4 cells/mm3 and >/=5000 HIV RNA copies/mL were assigned amprenavir (1200 mg) alone or with zidovudine (300 mg) plus lamivudine (150 mg), all given every 12 h. After a median follow-up of 88 days, the findings of a planned interim review resulted in termination of the amprenavir monotherapy arm. Among 85 subjects with confirmed plasma HIV RNA determination, 15 of 42 monotherapy versus 1 of 43 triple-therapy subjects had an HIV RNA increase above baseline or 1 log10 above nadir (P=.0001). For subjects taking triple therapy at 24 weeks, the median decrease in HIV RNA was 2.04 log10 copies/mL, and 17 (63%) of 27 evaluable subjects had <500 HIV RNA copies/mL. Treatment with amprenavir, zidovudine, and lamivudine together reduced the levels of HIV RNA significantly more than did amprenavir monotherapy.  (+info)

A 1-year multicenter randomized double-blind comparison of repaglinide and glyburide for the treatment of type 2 diabetes. Dutch and German Repaglinide Study Group. (4/1210)

OBJECTIVE: Repaglinide is a newly developed oral blood glucose-lowering agent that exerts its effect by stimulating insulin secretion. This multicenter study was designed to compare the efficacy and safety of this drug with glyburide in a 1-year randomized double-blind study of outpatients with type 2 diabetes. RESEARCH DESIGN AND METHODS: A total of 424 subjects (154 women, 270 men) participated and had the following characteristics: age, 61 +/- 9 years; duration of diabetes. 8 years (range 0.5-35); BMI, 28.3 +/- 3.5 kg/m2; HbA1c, 7.1 +/- 1.4%; and fasting plasma glucose, 10.8 +/- 3.1 mmol/l. The majority of the subjects (91%) were previously treated with sulfonylurea, alone or in combination with metformin. The patients were randomized to a 2:1 ratio of repaglinide (0.5-4 mg t.i.d.) or glyburide (1.75-10.5 mg daily) treatment. The study protocol included a screening visit to assess patient eligibility; a titration period of 6-8 weeks, during which the dosages of repaglinide and glyburide were optimized; and a subsequent 12-month treatment period on fixed, optimal dosages. RESULTS: The trial was completed by 320 subjects, 211 (74%) in the repaglinide and 109 (78%) in the glyburide group. HbA1c initially decreased in both groups and then increased during the second half-year of the maintenance period to a similar extent in the repaglinide and glyburide subjects (0.58 and 0.45% vs. at screening, respectively). In the small group of subjects who previously controlled their condition with diet only (n = 37), a sustained improvement of metabolic control could be observed with both drugs, which was slightly better with glyburide than with repaglinide (theta HbA1c -2.4 vs. -1.0%; P < 0.05). The same trends were seen with fasting plasma glucose. There were no changes in serum lipids. Over the course of the study, 15% of the repaglinide-treated and 13% of glyburide-treated subjects withdrew due to adverse events, mostly hyperglycemia. No differences in adverse events between both drugs were reported. There were no differences in incidences of hypoglycemia. CONCLUSIONS: Repaglinide is a safe and efficacious oral blood glucose-lowering agent, with a potency similar to that of glyburide. Its rapid onset of action and hepatic clearance allows meal-related administration, including in subjects with impaired kidney function.  (+info)

Structural and mechanistic aspects of transcriptional induction of cytochrome P450 1A1 by benzimidazole derivatives in rat hepatoma H4IIE cells. (5/1210)

The effect of several structurally different benzimidazole compounds on CYP1A1 expression at the transcriptional, mRNA and protein levels was investigated in the rat hepatoma H4IIE cell line. Omeprazole, thiabendazole, carbendazim, 2-mercaptobenzimidazole and 2-mercapto-5-methoxybenzimidazole caused a dose-dependent increase in CYP1A1 protein levels that reached maximum effect at 250 microm, as measured by Western blot. In addition, hydroxyomeprazole, 2-aminobenzimidazole and 2-mercapto-5-nitro-benzimidazole caused a notable increase in CYP1A1 protein expression, whereas 5-O-desmethylomeprazole, 2-hydroxybenzimidazole, 2-benzimidazole propionic acid and 5-benzimidazole carboxylic acid were ineffective. Thus, benzimidazole substituted with a thiol or an amino group in the 2-position were active inducers. Northern blot analysis confirmed an extensive increase of CYP1A1 mRNA induced by omeprazole and 2-mercapto-5-methoxybenzimidazole which was 32% and 49% of maximal induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) respectively, whereas thiabendazole and carbendazim showed approximately 15% increase as compared to TCDD. Transient transfection of H4IIE cells, with a XRE-pGL3 reporter gene construct revealed a 2.3-4.3-fold induction by carbendazim, thiabendazole, and 2-mercapto-5-methoxybenzimidazole as compared to a 3.3- and 23-fold induction by omeprazole and TCDD, respectively. Thus, these data indicate that the benzimidazoles utilize the aryl hydrocarbon receptor-arnt-XRE-mediated signal-transduction pathway for induction of the CYP1A1 gene.  (+info)

A common pharmacophore for cytotoxic natural products that stabilize microtubules. (6/1210)

Taxol (paclitaxel), a complex diterpene obtained from the Pacific yew, Taxus brevifolia, is arguably the most important new drug in cancer chemotherapy. The mechanism of cytotoxic action for paclitaxel-i.e., the stabilization of microtubules leading to mitotic arrest-is now shared by four recently identified natural products, eleutherobin, epothilones A and B, and discodermolide. Their ability to competitively inhibit [3H]paclitaxel binding to microtubules strongly suggests the existence of a common binding site. Recently, we have developed nonaromatic analogues of paclitaxel that maintain high cytotoxicity and tubulin binding (e.g., nonataxel). We now propose a common pharmacophore that unites paclitaxel, nonataxel, the epothilones, eleutherobin, and discodermolide, and rationalizes the extensive structure-activity relationship data pertinent to these compounds. Insights from the common pharmacophore have enabled the development of a hybrid construct with demonstrated cytotoxic and tubulin-binding activity.  (+info)

Pharmacological activities of TEI-8362, a novel inhibitor of human neutrophil elastase. (7/1210)

1. TEI-8362, 4-(N-(3-((3-carboxypropyl)amino)-8-methyl-1-oxo-4-azaisochromen-6- yl)carbamoyl)-4-((phenylmethoxy)carbonylamino)butanoic acid (C26H28N4O9) is a novel inhibitor of human neutrophil elastase (HNE). We evaluated its pharmacological profile in vitro and in vivo. 2. TEI-8362 demonstrated potent inhibition of HNE with a Ki value of 1.38 x 10(-9) M. Its selectivity for HNE among a variety of proteases ranged from 163 fold to 68,000 fold in favour of HNE. 3. The pulmonary haemorrhage that occurred after i.t. instillation of HNE to hamsters was inhibited by either i.t., i.v., or inhalant administration of TEI-8362. 4. Intratracheal administration of lipopolysaccharide induced pulmonary neutrophilia. Twenty-four hours after lipopolysaccharide administration, the additional treatment with formyl-methionyl-leucyl-phenylalanine resulted in a specific neutrophil-dependent acute lung injury. In this model, lung injury was significantly attenuated by i.t., i.v., or inhalant administration of TEI-8362. 5. These pharmacological actions of TEI-8362 suggest that this drug has therapeutic value in the treatment of destructive lung diseases due to neutrophils.  (+info)

Does an association between pesticide use and subsequent declines in catch of Atlantic salmon (Salmo salar) represent a case of endocrine disruption? (8/1210)

Historical aerial applications of the insecticide Matacil 1.8D provide an opportunity to look for potential effects of the endocrine disrupting compound 4-nonylphenol (4-NP) on Atlantic salmon (Salmo salar) populations. Matacil 1.8D contained the carbamate insecticide aminocarb, with 4-NP as primary solvent. Between 1975 and 1985 Matacil 1.8D was applied to forests in Atlantic Canada to control damage from the spruce budworm (Choristoneura fumiferana). After spraying, estimated concentrations of 4-NP in water fell within a range in which estrogenic effects might be anticipated. The spraying coincided with final stages of smolt development in salmon. Salmon catch data were evaluated considering effects on survival of the smolt stage. There was a significant negative relationship between the returns of salmon and the proportion of tributaries sprayed within the Restigouche River drainage basin in 1977. There was also a broader event of unusually heavy salmon smolt mortality in 1977, which contains a significant relationship indicating that where Matacil 1.8D spraying occurred, the smolt mortality increased. For 16 rivers exposed to spraying between 1973 and 1990, a significant proportion (p<0.005) of the lowest salmon catches coincided with Matacil 1.8D spraying. A decline coinciding with the use of Matacil 1.8D was also apparent in blueback herring (Alosa aestivalis) catches in New Brunswick. Because similar relationships were not evident for Matacil 1.8F or fenitrothion, neither of which were formulated with 4-NP, we hypothesize that the 4-NP in Matacil 1.8D was the causal agent. Concentrations of 4-NP described here are within current ranges encountered in industrial effluents and municipal sewage outfalls.  (+info)

*Carbamate

A carbamate is an organic compound derived from carbamic acid (NH2COOH). A carbamate group, carbamate ester (e.g., ethyl ... Carbamate nerve agents While the carbamate acetylcholinesterase inhibitors are commonly referred to as "carbamate insecticides ... Analogues of carbamates with only one of the oxygens replaced by sulfur are called thiocarbamates (2 and 3). Carbamates with ... For example, ammonium carbamate is generated by treatment of ammonia with carbon dioxide 2 NH3 + CO2 → NH4[H2NCO2] Carbamates ...

*Carbamate kinase

In enzymology, a carbamate kinase (EC 2.7.2.2) is an enzyme that catalyzes the chemical reaction ATP + NH3 + CO2 ⇌ {\ ... The systematic name of this enzyme class is ATP:carbamate phosphotransferase. Other names in common use include CKase, ... Bishop SH, Grisolia S (1966). "Crystalline carbamate kinase". Biochim. Biophys. Acta. 118 (1): 211-5. doi:10.1016/s0926-6593(66 ...

*Carbamate poisoning

... is poisoning due to exposure to carbamates. Carbamates are typically used as pesticides however some also ... King, Andrew M.; Aaron, Cynthia K. (February 2015). "Organophosphate and Carbamate Poisoning". Emergency Medicine Clinics of ...

*Methyl carbamate

Carbamate Ethyl carbamate (urethane) Jäger, Peter; Rentzea, Costin N.; Kieczka, Heinz (2005), "Carbamates and Carbamoyl ... Methyl carbamate also is used in the manufacture of pharmaceuticals, insecticides, and urethane. N-Methyl carbamates are widely ... Methyl carbamate is prepared by the reaction of methanol and urea: CO(NH2)2 + CH3OH → CH3OC(O)NH2 + NH3 It also forms in the ... Methyl carbamate is used primarily in the textile and polymer industries as a reactive intermediate. In the textile industry, ...

*Chlorphenesin carbamate

... (Maolate, Musil) is a centrally acting muscle relaxant used to treat muscle pain and spasms. ... Kurachi, M; Aihara, H (1984). "Effect of a muscle relaxant, chlorphenesin carbamate, on the spinal neurons of rats". Japanese ... Okuyama, S; Aihara, H (1987). "Antinociceptive effect of chlorphenesin carbamate in adjuvant arthritic rats". Research ...

*Ammonium carbamate

The ability of ammonium carbamate to make urea was first discovered in 1870 when Bassarov heated ammonium carbamate in sealed ... Ammonium carbamate can also be used as a good ammoniating agent. Compared to ammonia however, it is not nearly as strong an ... Ammonium carbamate is produced as an intermediate in this reactor and can then be dehydrated to urea according to the following ... Ammonium carbamate is the inorganic compound with the formula NH4[H2NCO2]. This salt formed by the reaction of ammonia with ...

*Ethyl carbamate

Other carbamates include methyl carbamate, butyl carbamate, and phenyl carbamate (m. p. 149-152 °C), which can also be prepared ... Carbamate Methyl carbamate Jäger, Peter; Rentzea, Costin N.; Kieczka, Heinz (2005), "Carbamates and Carbamoyl Chlorides", ... Ethyl carbamate was reclassified as a Group 2A carcinogen by IARC in 2007. Ethyl carbamate is frequently used as an anaesthetic ... Amounts of both ethyl carbamate and methyl carbamate have also been found in wines, sake, beer, brandy, whiskey and other ...

*Aminocarb

... is an carbamate insecticide widely used to protect cotton fields, crop fields, and forests from insect infestation. ... ISBN 978-1-4398-2060-5. Aizawa, Hiroyasu (2001). "Carbamates". Metabolic Maps. pp. 74-81. doi:10.1016/B978-012045605-5/50007-6 ...

*List of withdrawn drugs

"Ethyl carbamate". Retrieved 24 September 2013. DrugBank. "Fenfluramine". Retrieved 24 September 2013. DrugBank. "Iproniazid". ...

*Pesticide

Carbamate pesticides affect the nervous system by disrupting an enzyme that regulates acetylcholine, a neurotransmitter. The ... There are several subgroups within the carbamates.[citation needed] They were commonly used in the past, but many have been ... Organochlorines such as DDT were dominant, but they were replaced in the U.S. by organophosphates and carbamates by 1975. Since ... Organophosphates are quite toxic to vertebrates and have in some cases been replaced by less toxic carbamates. Thiocarbamate ...

*Chlorosulfonyl isocyanate

Conversion of primary alcohols to carbamates. Conversion of carboxylic acids and the acid chlorides into nitriles. Preparation ...

*Peachester Public Dip

... and carbamates. Research undertaken by C.J. Pound and later the Commonwealth Scientific and Industrial Research Organisation ( ...

*Methocarbamol

... is the carbamate of guaifenesin, but does not produce guaifenesin as a metabolite, because the carbamate bond is ... Unlike other carbamates such as meprobamate and its prodrug carisoprodol, methocarbamol has greatly reduced abuse potential. ... Parr JS, Khalifah RG (1992). "Inhibition of carbonic anhydrases I and II by N-unsubstituted carbamate esters". J Biol Chem. 267 ... All the major metabolites are unhydrolyzed carbamates. Methocarbamol is marketed under different names when presented in ...

*Phenylisocyanate

Similarly, reacts with alcohols to form carbamates. It is used in addition with triethylamine to activate nitro groups to ...

*Organophosphate poisoning

Carbamate poisoning can present similarly. Prevention includes banning very toxic types of organophosphates. Among those who ... Toxicity, Organophosphate and Carbamate at eMedicine Moore C (2009). Children and Pollution: Why Scientists Disagree. Oxford ... Current antidotes for OP poisoning consist of a pretreatment with carbamates to protect AChE from inhibition by OP compounds ... Leibson T, Lifshitz M (2008). "Organophosphate and Carbamate Poisoning: Review of the Current Literature and Summary of ...

*Chlorfenvinphos

King, Andrew M.; Aaron, Cynthia K. (February 2015). "Organophosphate and Carbamate Poisoning". Emergency Medicine Clinics of ...

*Carbamic acid

Carbamates usually refer to esters of carbamic acid. Methyl carbamate is the simplest ester of carbamic acid. Unlike carbamic ... The deprotonated anion (or conjugate base) of this functional group is a carbamate. Carbamic acid is a planar molecule. ... ISBN 978-0-7817-3481-3. Risher, JF; Mink, FL; Stara, JF (1987). "The toxicologic effects of the carbamate insecticide aldicarb ... carbamate group carbamoyl (Cbm) group carbamoyl chloride group Carbamic acids are intermediates in the decomposition of ...

*GABAA receptor

Positive allosteric modulators: barbiturates, benzodiazepines, certain carbamates (ex. carisoprodol, meprobamate, lorbamate), ...

*Pesticide poisoning

If one is regularly using carbamate and organophosphate pesticides, it is important to obtain a baseline cholinesterase test. ... Ramesh C. Gupta (28 April 2011). Toxicology of Organophosphate & Carbamate Compounds. Academic Press. pp. 352-353. ISBN 978-0- ... carbamates, and anticholinesterases, are most commonly reported in occupationally related pesticide poisonings globally. ...

*Fenobucarb

... is a carbamate insecticide. A pale yellow or pale red liquid, insoluble in water; used as an agricultural ... "N-Methyl Carbamate Insecticides" (pdf). Oregon State University. "Fenobucarb - toxicity, ecological toxicity and regulatory ... N-methyl O-sec-butylPhenyl carbamate Fenobucarb, Osbac, Bassa Male Mouse 340 mg/kg Male Rat 410 mg/kg Takahashi, H.; Miyaoka, T ...

*Oxamyl

... is a carbamate pesticide. According to the WHO Food and Agriculture Organization, "Oxamyl is a colourless crystalline ...

*Juvenile-hormone esterase

... carbamate insecticides were also tested. By far the most potent inhibitor was an ethoxythiophenylphospamidothiolate, with IC50 ...

*Flavin-containing monooxygenase 3

... such as organophosphates and carbamates [14-22]. Cashman JR (September 2000). "Human flavin-containing monooxygenase: substrate ...

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5) Related O-aryl carbamates are good directing groups; upon warming, the resulting organolithiums undergo rearrangement to ... 6) Secondary N-aryl carbamates (along with secondary amides, ketones, and other directing groups containing acidic hydrogens) ... carbamates, and sulfonates. Lateral lithiation of alkyl-substituted heterocycles incorporating heteroatom-containing ...

*Photolabile protecting group

Cameron, J. F.; Frechet, J. M. J. (May 1991). "Photogeneration of Organic Bases from o-Nitrobenzyl-Derived Carbamates". Journal ... Overall, phenacyl PPGs can be used to protect sulfonates, phosphates, carboxylates and carbamates. As with nitrobenzyl-based ... carbamates, thiolates, phenolates and alkoxides. Additionally, while the rate varies with a number of variables, including ... this substitution is only able to release good leaving groups such as carbamates and carboxylates. Additionally, the addition ...
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Carbosulfan (2,3-dihydro-2,2dimethyl-7-benzofuronyl [(dibutyl amino) thio] methyl] a carbamate insecticide and acaricide was administered orally at an effective dose of 48 mg/kg/day to albino mice for 5, 10, 20 and 30 days .Control mice received similar quantities of olive oil. Daily body weights were recorded and mice were sacrificed after 24 hours after the terminal exposure. The histologic examination of liver of the mice treated with carbosulfan for 10, 20 and 30 days revealed the dilation of central vein and sinusoids between hypertrophied hepatocytes. Vacuolization and hyalinization of hepatocytes with loss of radial arrangement. Treatment with carbosulfan for 20 days in female and male mice resulted in a significant decrease in protein and liver glycogen contents in female mice, whereas in male mice the glycogen was not changed significantly in the liver. The cholesterol content was increased significantly in male mice, but in female mice there was no significant change. Treatment with
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Fegley, D., Gaetani, S., Duranti, A., Tontini, A., Mor, M. and Tarzia, G. (2005) Characterization of the fatty acid amide hydrolase inhibitor cyclohexyl carbamic acid 3- carbamoyl-biphenyl-3-yl ester (URB597), effects on anandamide and oleoylethanolamide deactivation. Journal of Pharmacology & Experimental Therapeutics, 313, 352-358. doi10.1124/jpet.104.078980
Surface water sampling in 2007-2010 measured the incident of carbamates and metalaxyl during bottom flow circumstances and wet weather conditions occasions in southern Ontario surface area waters. may possess resulted from KC-404 squirt drift mainly. on an array of vegetation was?contained in the analytical method. While specialized enrollment of both carbofuran and pirimicarb in Canada provides expired both items had been used during a number of the monitoring period (2007-2010) and by the finish of 2013 had been still in the residue explanations list beneath the Canadian Infestations Control Products Action and supervised by Provincial and Government agencies (Wellness Canada 2013). Environment Canada undertook surface area drinking water sampling for carbamates and metalaxyl over the time 2007-2010 in Ontario Canada. The goal of this research was to gauge the incident and distribution of carbamate pesticides and metalaxyl in southern Ontario surface area waters within a thorough pesticide ...
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This study allows patients who have successfully participated in ACTG 347 or other trials involving amprenavir to continue treatment with amprenavir, ZDV, d4T, and 3TC. Additionally, this study provides patients whose HIV-1 RNA was not reduced to undetectable levels or who had a significant increase in plasma levels (treatment failures) the opportunity to change to a potentially more active regimen that includes indinavir, nevirapine, lamivudine, and stavudine.. Patients with HIV RNA less than 500 copies/ml on a regimen containing amprenavir are treated on Arm A; those with greater than or equal to 500 copies while on or intolerant to a regimen containing amprenavir are treated on Arm B.. Arm A: Amprenavir + ZDV + d4T + 3TC. Arm B: IND + NVP + 3TC + d4T. Patients enrolled in Arm A who fail therapy may roll over to Arm B. Patients in Arm B who fail therapy discontinue study medications and seek best available treatment.. [AS PER AMENDMENT 2/27/98: Patients with HIV RNA less than 500 copies/ml ...
This study allows patients who have successfully participated in ACTG 347 or other trials involving amprenavir to continue treatment with amprenavir, ZDV, d4T, and 3TC. Additionally, this study provides patients whose HIV-1 RNA was not reduced to undetectable levels or who had a significant increase in plasma levels (treatment failures) the opportunity to change to a potentially more active regimen that includes indinavir, nevirapine, lamivudine, and stavudine.. Patients with HIV RNA less than 500 copies/ml on a regimen containing amprenavir are treated on Arm A; those with greater than or equal to 500 copies while on or intolerant to a regimen containing amprenavir are treated on Arm B.. Arm A: Amprenavir + ZDV + d4T + 3TC. Arm B: IND + NVP + 3TC + d4T. Patients enrolled in Arm A who fail therapy may roll over to Arm B. Patients in Arm B who fail therapy discontinue study medications and seek best available treatment.. [AS PER AMENDMENT 2/27/98: Patients with HIV RNA less than 500 copies/ml ...
A curable coating composition is described comprising a carbamate functional material and a crosslinking agent, reactive with the carbamate group. The composition further comprises a third component that is a mixture of catalysts including a phosphorus containing acid or acid derivative and other acid catalysts. Coatings prepared with this coating composition can be cured and coated with additional coating(s), providing good intercoat adhesion to the subsequent coating.
Emergence of resistance to protease inhibitor amprenavir in human immunodeficiency virus type 1-infected patients: Selection of four alternative viral protease genotypes and influence of viral susceptibility to coadministered reverse transcriptase nucleoside inhibitors ...
The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. However, NIST makes no warranties to that effect, and NIST shall not be liable for any damage that may result from errors or omissions in the Database ...
dosed preprandially with three meals. Absorption After oral administration, repaglinide is completely absorbed from the gastrointestinal tract. After single and multiple oral doses in healthy subjects or in patients, peak plasma drug levels (Cmax) occur within 1 hour (Tmax). Repaglinide is eliminated from the blood stream with a half-life of approximately 1 hour. The mean absolute bioavailability is 56%. When repaglinide was given with food, the mean Tmax was not changed, but the mean Cmax and AUC (area under the time/plasma concentration curve) were decreased 20% and 12.4%, respectively.. Distribution After intravenous (IV) dosing in healthy subjects, the volume of distribution at steady state (Vss) was 31 L, and the total body clearance (CL) was 38 L/h. Protein binding and binding to human serum albumin was greater than 98%.. Metabolism and Elimination. Repaglinide is completely metabolized by oxidative biotransformation and direct conjugation with glucuronic acid after either an IV or oral ...
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Repaglinide Krka is an oral antidiabetic treatment medicine containing repaglinide which helps your pancreas produce more insulin and thereby lower blood su
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Loza Einars; Amolins Andris; Semenikhina Valentina; Lola Daina; Ritchie James; William Finn Paul; Watkins Clare; Rosario Romero Martin Maria; Starchenkov Igors; Dikovska Klara; Kalvins Ivars; Moore Kathryn; Bokaldere Rasma; Gailite Vija; Vorona Maksims; Andrianov Victor; Harris C John; Duffy James. Carbamic acid compounds comprising an amide linkage as HDAc inhibitors. DE60115279, 28.12.2006 ...
Loza Einars; Amolins Andris; Semenikhina Valentina; Lola Daina; Ritchie James; William Finn Paul; Watkins Clare; Rosario Romero Martin Maria; Starchenkov Igors; Dikovska Klara; Kalvins Ivars; Moore Kathryn; Bokaldere Rasma; Gailite Vija; Vorona Maksims; Andrianov Victor; Harris C John; Duffy James. Carbamic acid compounds comprising an amide linkage as HDAc inhibitors. EP2083005, 29.07.2009 ...
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Repaglinide is a meglitinide antidiabetic. It works to lower blood glucose (sugar) by stimulating the release of insulin from the pancreas gland.. ...
This portion of the eMedTV library explains that there are potential side effects of repaglinide to be aware of, including headaches, sinus infection, and low blood sugar. This article also highlights some of the serious side effects of the drug.
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bi·phenyl; phenyl; phenyl·acetaldehyde; phenyl·acetamide; phenyl·acetic; phenyl·alanine; phenyl·bu·ta·zone; phenyl·carbamate; phenyl·carbamic; phenyl·ene; phenyl·ene·diamine; phenyl·eph·rine; phenyl·ethyl; phenyl·ethylene; phenyl·glycine;…
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The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. However, NIST makes no warranties to that effect, and NIST shall not be liable for any damage that may result from errors or omissions in the Database ...
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Fatty acid amide hydrolase (FAAH) is responsible for hydrolysis of endocannabinoid, anandamide (AEA), and N-acyl ethanolamines such as palmitoylethanolamine (PEA) and N-oleoylethanolamide (OEA). Genetic deletion or pharmacological inactivation of FAAH shows site-specific elevation of AEA that plays a role in the modulation of pain and other neurodegenerative disorders. The review elaborates recent progress and current status of diverse structural classes of reversible and irreversible FAAH inhibitors. The discussion also addresses ligand-enzyme active site interactions and mechanism of enzyme inactivation, emerging approaches to novel FAAH inhibitors, and ongoing efforts to address gaps in therapeutic utility of FAAH inhibitors.
As a member of the transient receptor potential (TRP) ion channel superfamily, the ligand-gated ion channel TRPA1 has been implicated in nociceptive function and pain states. The endogenous ligands that activate TRPA1 remain unknown. However, various agonists have been identified, including environmental irritants (e.g., acrolein) and ingredients of pungent natural products [e.g., allyl isothiocyanate (ITC), cinnamaldehyde, allicin, and gingerol]. In general, these agents are either highly reactive, nonselective, or not potent or efficacious, significantly limiting their utilities in the study of TRPA1 channel properties and biological functions. In a search for novel TRPA1 agonists, we identified 3 -carbamoylbiphenyl-3-yl cyclohexylcarbamate (URB597), a potent and systemically active inhibitor of fatty acid amide hydrolase (FAAH). This enzyme is responsible for anandamide degradation and therefore has been pursued as an antinociceptive and antiepileptic drug target. Using Ca influx assays and patch
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HPLC Application #18282: Carbamate Pesticides on Kinetex 2.6µm C18 50 x 4.6mm ID. Column used: Kinetex® 2.6 µm C18 100 Å, LC Column 50 x 4.6 mm, Ea Part#: 00B-4462-E0
0015]Due to the relative stability amides in vivo, N-acylation of amines to give amide prodrugs has only been used to a limited extent (H. Bundgaard H & M. Johansen, J Pharm Sci., 69 (1980) 44-6). For the same reason, the utility of carbamates as prodrug derivatives for amines is also limited. Introducing an enzymatically hydrolyzable ester function into the carbamate structure may evade such problem. N-(acyloxyalkoxycarbonyl) derivatives of primary or secondary amines are likely to be transformed to the parent amine in vivo (J. Alexander, R. Cargill, S. R. Mohelson and H. Schwamm, J. Med. Chem., 31 (1988) 316-22; U. S. Gates & A. J. Repta, Int. J. Pharm., 40 (1987) 249-55). Enzymatic based hydrolysis of such ester moiety in those derivatives will lead to a (hydroxy-alkoxy)carbonyl derivative which spontaneously decomposes into parent amine via an unstable carbamic acid. Acyloxy-alkyl carbamates as shown in Table 5 and Example 11 are promising biolabile prodrugs for amino functional drugs, since ...
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Applications were made from growth stages R1 (flowering) to R3 (podset) (2), with more than 60% of the trials receiving a pyraclostrobin application at growth stage R3. Locations of fungicide strips were recorded with on-board GPS systems in all 14 trials that received aerial fungicide applications and in approximately 90% of the trials that received ground fungicide applications. In the remaining 10% of the trials, farmers flagged the strips during fungicide applications and recorded GPS coordinates of each strip later during the growing season. Treatments were alternated within each trial to help farmers accommodate treatment applications, allow researchers to verify treatment locations and conduct analysis of yield responses observed at both field and within-field (spatial observations) levels. All discussions in this article are focused only on field-level mean yield responses. More information about the purpose, methodology, and statistical analysis of observations collected in similar ...
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Generic Name: Fosamprenavir calcium. Brand Name: Telzir. Manufacturer: GlaxoSmithKline Inc.. Indications: HIV infection. Submission Type: New. Project Status: Complete. Date Recommendation Issued: June 16, 2005. Recommendation Type: List in a similar manner to other drugs in class. ...
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In case of emergency-There may be a time when you need emergency help for a problem caused by your diabetes. You need to be prepared for these emergencies. It is a good idea to wear a medical identification (ID) bracelet or neck chain at all times. Also, carry an ID card in your wallet or purse that says that you have diabetes and a list of all of your medicines.. Too much repaglinide can cause low blood sugar (hypoglycemia). Low blood sugar also can occur if you use repaglinide with another antidiabetic medicine, delay or miss a meal or snack, exercise more than usual, drink alcohol, or cannot eat because of nausea or vomiting. Symptoms of low blood sugar must be treated before they lead to unconsciousness (passing out). Different people may feel different symptoms of low blood sugar. It is important that you learn which symptoms of low blood sugar you usually have so that you can treat it quickly.. Symptoms of low blood sugar include anxiety; behavior change similar to being drunk; blurred ...
Section 1 of this thesis contains an introduction to method development in organic synthesis, multicomponent reactions, sulfonyl azides, tracer development in 11C chemistry and the biological target.. Section 2 describes the use of sulfonyl azides in carbonylative chemistry. Paper I covers development of a diazotransfer protocol. In total, 30 arylsulfonyl azides were synthesised from primary sulfonamides (20-90% yield). 15N mechanistic studies were carried out and in Paper II, the products were converted into sulfonamides, sulfonylureas and sulfonyl carbamates (19-90% yield). For ureas and carbamates, a two-chamber protocol was employed to release CO from Mo(CO)6. 15N mechanistic studies showed that the sulfonamides were formed by direct displacement of azide.. Section 3 covers imaging and biological studies of the angiotensin II receptor subtype 2 (AT2R). In Paper III, 12 11C-sulfonyl carbamates were prepared in isolated radiochemical yields of 3-51% via Rh(I)-mediated carbonylation. The first ...
Hydrolysis o f the original sample to the corresponding carbamate, G T X 3 (5), w o u l d increase the toxicity o f the sample 6-fold, to 1400 mouse units. Subsequent epimerization o f the hydrolysate, 5, to a 4:1 mixture o f the carbamates GTX2 (3) and 5 (or hydrolysis o f the epimeric sulfamates 4 and 6 to the same mixture o f carbamates) w o u l d then change the toxicity to 1,120 mouse units. T h e observed toxicity and composition o f the hypothetical sample w h i c h started as pure 6 may l i e anywhere w i t h i n the indicated bounds as these interconversions occur. It can be increased at any point by hydrolysis, toward the toxicity shown o n the upper line. T h e highest toxicity w i l l be attained i f the hydrolysis is performed o n 6 prior to epimerization, resulting i n 5. Hydrolysis o f the epimeric 4 and 6, o r epimerization o f the hydrolysate, will ultimately result i n a stable, equilibrated mixture o f the epimers 3 and 5, with a slightly lower toxicity. T h e hypothetical ...
Preparation of a 1,2,4-triazol-3-one compound substituted in positions 4 and 5 by an alkyl or aryl group and, optionally, in position 2 by an alkyl group, by reacting an ester a of carbamic acid N-substituted by an alkyl or aryl group with a hydrazide of an aliphatic or aromatic carboxylic acid, optionally N-substituted by an alkyl group, in the presence of a strong base.
Repaglinide is presently recommended by the U.S. Food and Drug Administration as a clinical CYP2C8 probe, yet current in vitro and clinical data are inconsistent concerning the role of this enzyme in repaglinide elimination. The aim of the current study was to perform a comprehensive investigation of repaglinide metabolic pathways and assess their contribution to the overall clearance. Formation of four repaglinide metabolites was characterized using in vitro systems with differential complexity. Full kinetic profiles for the formation of M1, M2, M4, and repaglinide glucuronide were obtained in pooled cryopreserved human hepatocytes, human liver microsomes, human S9 fractions, and recombinant cytochrome P450 enzymes. Distinct differences in clearance ratios were observed between CYP3A4 and CYP2C8 for M1 and M4 formation, resulting in a 60-fold M1/M4 ratio in recombinant (r) CYP3A4, in contrast to 0.05 in rCYP2C8. Unbound Km values were within 2-fold for each metabolite across all in vitro ...
|p|Amprenavir (agenerase), an |em|N,N|/em|-disubstituted hydroxyethylamino sulfonamide, is a novel inhibitor of human immunodeficiency virus type 1 (HIV-1) protease that potently inhibits the activity of HIV-1 protease with a value of 50% inhibition conce
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Repaglinide can cause low blood sugar (hypoglycemia) especially if you are taking other medicines for diabetes. Consuming large quantities of alcohol, not getting enough calories from food, or doing unusually heavy exercise may also lead to low blood sugar. Symptoms may include chills, cold sweat, dizziness, drowsiness, shaking, fast heartbeat, weakness, headache, fainting, tingling of the hands or feet, or hunger. It is a good habit to carry glucose tablets or gel to treat low blood sugar. If you dont have these reliable forms of glucose, raise your blood sugar quickly by eating a quick source of sugar such as table sugar, honey, candy, or drinking a glass of fruit juice or non-diet soda. Check with your doctor or pharmacist to find out what you should do if you miss a meal ...
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The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites ...
Pirimicarb 2-dimethylamino-5,6-dimethylpyrimidin-4-yldimethylcarbamate is used as insecticide in agriculture and fruit growing. During its metabolism in mammals the carbamate moiety is hydrolysed and subsequent demethylation at the dimethylaminogroup which is attached to the heterocyclic moiety results in the following major metabolites which...
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Alan Stern wrote: , On Tue, 23 Apr 2013, Clemens Ladisch wrote: ,, Why is having a queue of two URB with one packet each suddenly not ,, allowed? , , It _is_ allowed when URB_ISO_ASAP is clear. I have never fully , understood why the audio driver sets that flag. By setting it, you are , telling the host controller driver that you are willing to give up , reduced latency in order to avoid underruns. This flag was needed to avoid having to set urb-,start_frame. With the changed queueing API, the audio driver needs to change too. Ill look into this ... Regards, Clemens -- To unsubscribe from this list: send the line unsubscribe alsa-devel in the body of a message to majordomo at vger.kernel.org More majordomo info at http://vger.kernel.org/majordomo-info.html ...
The acute toxicity of carbosulfan and chlorpyrifos in formulated pesticides to glochidia (larvae) of the freshwater mussel (Hyriopsis bialata Simpson, 1900) was evaluated under static conditions in moderately hard dechlorinated tap water. Measured pesticide concentrations were 26 to 34% lower than nominal concentrations; therefore, all results are expressed in terms of measured active ingredient. Carbosulfan was relatively non-toxic to the mussel larvae with median effective concentrations (EC50) of carbosulfan at 24 and 48 h greater than 0.10 mg/L. The EC50s of chlorpyrifos at 24 and 48 h were 0.083 and 0.078 mg/L, respectively (measured concentrations). The 48-h EC50 of a combined exposure to a mixture of chlorpyrifos and carbosulfan at a constant ratio of 2.9:1 was 0.0142:0.049 mg CP:CB/L. In a separate experiment, the effect of water hardness on carbosulfan, chlorpyrifos, or a combined exposure was assessed using glochidia exposed to either soft, moderately hard, or hard reconstituted water. ...
Several factors contribute to the deterioration in synaptic plasticity which accompanies age and one of these is neuroinflammation. This is characterized by increased microglial activation associated with increased production of proinflammatory cytokines like interleukin-1β (IL-1β). In aged rats these neuroinflammatory changes are associated with a decreased ability of animals to sustain long-term potentiation (LTP) in the dentate gyrus. Importantly, treatment of aged rats with agents which possess anti-inflammatory properties to decrease microglial activation, improves LTP. It is known that endocannabinoids, such as anandamide (AEA), have anti-inflammatory properties and therefore have the potential to decrease the age-related microglial activation. However, endocannabinoids are extremely labile and are hydrolyzed quickly after production. Here we investigated the possibility that inhibiting the degradation of endocannabinoids with the fatty acid amide hydrolase (FAAH) inhibitor, URB597, could
China Agrochemicals Plant Fungal Diseases Control Fungicide Mixed Formulation Pyraclostrobin, Find details about China Pyraclostrobin, Fungicide from Agrochemicals Plant Fungal Diseases Control Fungicide Mixed Formulation Pyraclostrobin - Shanghai Fuang Agrochemical Co. Ltd.
Malolactic fermentation of a Chardonnay wine with five different strains of lactic acid bacteria (Leuconostoc oenos) showed no detectable amounts (, 10 µg/L) of ethyl carbamate. Heating of these wine samples, however, produced around 100µg/L of ethyl carbamate. Control samples which had not undergone malolactic fermentation contained, after heating, amounts of ethyl carbamate similar to the malolactic-fermented samples. Removal of the yeast by sterile microfiltration did not affect the ethyl carbamate formation during heating.. ...
Fosamprenavir BASE CAS 226700-79-4 [(1S,2R)-3-[[(4-Aminophenyl)sulfonyl](2-methylpropyl)amino]-1-(phenylmethyl)-2-(phosphonooxy)propyl]carbamic acidC-[(3S)-tetrahydro-3-furanyl] ester Additional Names: (3S)-tetrahydro-3-furyl [(aS)-a-[(1R)-1-hydroxy-2-(N1-isobutylsulfanilamido)ethyl]phenethyl]carbamate dihydrogen phosphate (ester) Manufacturers Codes: VX-175 Molecular Formula: C25H36N3O9PS Molecular Weight: 585.61 Percent Composition: C 51.27%, H 6.20%, N 7.18%, O 24.59%, P 5.29%, S 5.48% WO 9933815 PRODUCT PATENT Fosamprenavir Systematic (IUPAC) name {[(2R,3S)-1-[N-(2-methylpropyl)(4-aminobenzene)sulfonamido]-3-({[(3S)-oxolan-3-yloxy]carbonyl}amino)-4-phenylbutan-2-yl]oxy}phosphonic acid Clinical data Trade names Lexiva AHFS/Drugs.com monograph…
Effective Agrochemical Fungicide Carbendazim 25%WP 50%WP Best Price,US $ 1.25 - 3.98 / Kilogram, Biological Pesticide, Fungicide, Nematicide, 10605-21-7, Carbendazole Mercarzole.Source from Yiwu S-Ling Import And Export Co., Ltd. on Alibaba.com.
More than 50% of exposures to organophosphate and carbamate pesticides involve children younger than 6 years. Several factors make these pediatric cases difficult to diagnose. Often the child is too young to give a history, and the parents might not suspect that oral or topical pesticide exposure has occurred. In addition, the typical respiratory and gastrointestinal symptoms of the cholinergic syndrome may be mistaken for those of common childhood illnesses: bronchitis, pneumonia, upper respiratory infection, or gastroenteritis. Finally, some studies have indicated that well-recognized manifestations of cholinergic toxicity in adults-for example, bradycardia and muscle fasciculations-occur in only a minority of pediatric cases, whereas tonic-clonic seizures occur more frequently in children.1 A high index of suspicion allows early diagnosis, which will not only facilitate optimal treatment for the individual patient but may also provide early warning of contamination in the childs home or ...
In accordance with Article 43 of Regulation (EC) No 396/2005, the European Commission requested EFSA to evaluate the information provided by the European Spice Association (ESA) with a view to setting an import tolerance on cultivated mushrooms and considering in parallel, a review of all existing EU MRLs for the N-methyl-carbamate insecticides; carbofuran, carbosulfan, benfuracarb and furathiocarb, including the CXLs that were taken over in the EU legislation. EFSA recommends the withdrawal of the carbofuran and/or carbosulfan CXLs transposed in the EU legislation for mandarin, orange, sunflower, rape seed and spices. EFSA recommends, to maintain the MRL for carbofuran in fresh cultivated mushrooms at the current LOQ of 0.01* mg/kg, since higher values will result in an acute consumer intake concern. No changes are proposed to the benfuracarb and furathiocarb MRLs (LOQs) listed in Annex V of Regulation (EC) No 396/2005. In contrast, for carbofuran and having regard to the low toxicological ...
Additional supportive treatment must be given, which could include light anaesthesia ordeep sedation and fluid therapy until the dog has eliminated the poison. References1. Aaron C K, Howland M A1994 Insecticides: Organophosphates and carbamates. In Goldfranks Toxicologic Emergencies 5th Edition Goldfrank L R, Florenbaum N E,Lewin N A, Weisman R S Howland M A, Hoffman R S (ed) Appleton & Lange,Norwalk 1105 - 1114 2. Adams H R 1988 Cholinergic pharmacology. Autonomic drugs. In Veterinary Pharmacology and Therapeutics Booth N H, McDonald L E (ed) Iowa StateUniversity Press, Iowa 117 - 123 3. Barret D S, Oehme F W, Kruckenberg S M 1985 A review of organophosphorus ester-induced delayed neurotoxicity. Veterinary and Human Toxicology 27(1): 22 -37 4. Beasley V R, Dorman D C 1990 Management of toxicoses. The Veterinary Clinics of North America: Small Animal Practice 20(2): 307 - 337 5. Blakley B R, Yole M J 2002 Species differences in normal brain cholinesterase activities of animals and birds. ...
- The report summarizes all the dormant and discontinued pipeline projects - A review of the Organophosphate And Carbamate Poisoning products under development by companies and universities/research institutes based on information derived from company and industry-specific source。
I hope youre paying close attention to what Im explaining here, because what the study mentioned above reveals is that DEET is part of a binary chemical weapon system that goes "ballistic" against your nerve cells when combined with certain classes of insecticides (such as carbamates and OPs).. What are carbamate insecticides? They are a class of pesticide chemicals that are right now being sprayed on food crops all across America. Even worse, theyre often used in aerial spraying campaigns in combination with DEET. In effect, this is a chemical binary weapon now being deployed against the American people.. "Deet is commonly used in combination with insecticides and we show that deet has the capacity to strengthen the toxicity of carbamates, a class of insecticides known to block acetylcholinesterase," says the BioMedCentral science paper linked above.. Adding to the concern, this warning from MDguidelines.com explains, "Over 80% of the pesticide poisonings in the US are caused by ...
An intensified, industrially-relevant strategy for the production of enantiopure halophenylalanines has been developed using the novel combination of a cyanobacterial phenylalanine ammonia lyase (PAL) and ammonium carbamate reaction buffer. The process boasts STYs up to |200 g L−1 d−1, ees ≥ 98% and simplifi Celebrating the 2017 RSC Prize and Award Winners
Organophosphates and carbamates are the most frequently used insecticides worldwide. These compounds cause 80% of the reported toxic exposures to insecticides.
Fenbendazole Animal Pharmaceuticals with EP7 USP34 pass FDA ,COS,, 43210-67-9, [5-(phenylthio)-1H-benzimidazol-2-yl]carbamic acid methyl ester; Panac, C15H13N3O2S.Source from Novachem (Wuhan) Import & Export Company Ltd. on Alibaba.com.
This page of the eMedTV library describes the complications that may occur when amprenavir is taken with delavirdine, dexamethasone, ergot medications, hormonal contraceptives, and more, with information on how to reduce your risk.
Get Express Shipping With Online Orders. Our Range Of Products Includes Medicines, OTC Products, Prescription Drugs. Affordable Medications At A Discounted Price. Repaglinide And Metformin Combination.
s-[(3s)-3-methyl-1-cyclohexen-1-yl] ester c11h19nos (cas 255851 , 宽300x300高 , 显示比例:100% , 查看原图 , 图片来源 ...
For the detection of a wide range of organophosphates including thiophosphate and carbamate pesticides using a colorimetric immunoassay (ELISA) procedure. Microtiter plate format with ready to use reagents. Enables faster assay kinetics, super sensitivity and the simultaneous measurement of multiple samples. (96 Tests). Learn More ...
A study published ahead of print in the The Journal of General Physiology has revealed new insights into Retigabine, a known pharmacological treatment for epilepsy.
In the title compound, C18H22N2O4S2, the 2H-chromene ring system is essentially planar (r.m.s. deviation = 0.012 A ° ). The molecular conformation is stabilized by a C-H� � �O hydrogen bond. In the crystal, N-H� � �S and C-H� � �O hydrogen bonds occur, the former enclosing an R2 2(22) ring motif, and lead to the formation of a two-dimensional slab-like network lying parallel to (101). �-� interactions are observed between inversion-related aromatic rings [shortest centroid-centroid distance = 3.6300 (11) A ° ].. ...
Discussion. During the reporting period, a number of vultures were poisoned with organophosphorus or carbamate compounds. On a number of occasions only the crops or the digestive tract were submitted and the specific vulture species involved was not provided, nevertheless, the majority of incidents included African white-backed vultures (Gyps africanus). The indiscriminate use of highly toxic agricultural pesticides by farmers to kill jackals and feral marauding dogs may have a serious ecological impact, as can be seen from the incident in 2013 in which 49 vultures (48 Cape vultures [G. coprotheres] and one African white-backed vulture) were poisoned when a farmer laced sheep carcases with carbofuran to kill jackals preying on new-born lambs (Wildlife Extra.com 2013). This is in contravention of the law as these compounds should be used strictly for the indications for which they are registered (Act 36 of 1947; Government Gazette Regulation No. R.1716 1991). Virani et al. (2011) surmised that ...
0044]The (4-methyl-thiophen-3-yl)-carbamic acid tert-butyl ester was then selectively chlorinated with a chlorinating agent such as N-chlorosuccinimide (NCS) and catalytic hydrochloric acid (HCl) or alternatively, by metalation with N-butyl lithium and reaction with hexachloroethane (Cl3C2Cl3) to form 2-chloro-4-methyl-thiophen-3-yl)-carbamic acid tert-butyl ester. This ester is then treated with hydrogen chloride gas to remove the protecting group so as to form the 3-amino-2-chloro-4-methylthiophene hydrochloride. In step 3, the 3-amino-2-chloro-4-methylthiophene hydrochloride is activated for coupling by treatment with phenyl chlorothionoformate and sodium bicarbonate. This intermediate was subsequently treated with 1,2-phenylenediamine and triethylamine to afford N-(2-aminophenyl)-N-(2-chloro-4-methyl-3-thienyl)thiourea. The thiourea was cyclized utilizing an alkyl or arylsulfonyl chloride such as p-toluenesulfonyl chloride or benzenesulfonyl chloride together with an alkali metal base such ...
Carbendazim is a widely used, broad-spectrum benzimidazole fungicide and a metabolite of benomyl. It is also employed as a casting worm control agent in amenity turf situations such as golf greens, tennis courts etc. and in some countries is licensed for that use only. The fungicide is used to control plant diseases in cereals and fruits, including citrus, bananas, strawberries, pineapples, and pomes. It is also controversially used in Queensland, Australia on macadamia plantations. A 4.7% solution of carbendazim hydrochloride, sold as Eertavas, is marketed as a treatment for Dutch elm disease. Studies have found high doses of carbendazim cause infertility and destroy the testicles of laboratory animals. Maximum pesticide residue limits (MRLs) have reduced since discovering its harmful effects. The MRLs for fresh produce in the EU are now between 0.1 and 0.7 mg/kg with the exception of loquat, which is 2 mg/kg. The limits for more commonly consumed citrus and pomme fruits are between 0.1 and 0.2 mg/kg.
Cholinesterase (ChE) activity was used as a biomarker for assessing exposure of common carp (Cyprinus carpio) to organophosphate and carbamate insecticides from irrigated agricultural waters. Carp were collected from a lake (Royal Lake) that receives most of its water from irrigation return flows and from a reference lake (Billy Clapp Lake) outside of the irrigation system. Results indicated that the mean whole-brain ChE activity of carp from Royal Lake (3.47 μmol/min/g tissue) was 34.2% less than that of carp from Billy Clapp Lake (5.27 μmol/min/g tissue) (p = 0.003). The depressed ChE activity in brain tissue of Royal Lake carp was in response to ChE-inhibiting insecticides detected in water samples in the weeks prior to tissue sampling; the most frequently detected insecticides included chlorpyrifos, azinphos-methyl, carbaryl, and ethoprop. Neither sex nor size appears to be a covariable in the analysis; ChE activity was not correlated with fish length or weight...
Background Recent data have indicated that there may be a dysregulation of endocannabinoid metabolism in cancer. Here we have investigated the expression of the endocannabinoid metabolising enzyme fatty acid amide hydrolase (FAAH) in a well characterised tissue microarray from patients diagnosed with prostate cancer at transurethral resection for voiding problems. Methodology/Principal Findings FAAH immunoreactivity (FAAH-IR) was assessed in formalin-fixed paraffin-embedded non-malignant and tumour cores from 412 patients with prostate cancer. CB1 receptor immunoreactivity (CB1IR) scores were available for this dataset. FAAH-IR was seen in epithelial cells and blood vessel walls but not in the stroma. Tumour epithelial FAAH-IR was positively correlated with the disease severity at diagnosis (Gleason score, tumour stage, % of the specimen that contained tumour) for cases with mid-range CB1IR scores, but not for those with high CB1IR scores. For the 281 cases who only received palliative therapy at the
The endocannabinoids anandamide and 2-arachidonoylglycerol are metabolised by both hydrolytic enzymes (primarily fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MGL)) and oxygenating enzymes (e.g. cyclooxygenase-2, COX-2). In the present article, the in vivo data for compounds inhibiting endocannabinoid metabolism have been reviewed, focussing on inflammation and pain. Potential reasons for the failure of an FAAH inhibitor in a clinical trial in patients with osteoarthritic pain are discussed. It is concluded that there is a continued potential for compounds inhibiting endocannabinoid metabolism in terms of drug development, but that it is wise not to be unrealistic in terms of expectations of success.. ...
Use Prandin regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.. MORE INFO. Active ingredient: Repaglinide. Repaglinide is a white to off-white powder with molecular formula C27 H36 N2 O4 and a molecular weight of 452.6. PRANDIN tablets contain 0.5 mg, 1 mg, or 2 mg of repaglinide. In addition each tablet contains the following inactive ingredients: calcium hydrogen phosphate (anhydrous), microcrystalline cellulose, maize starch, polacrilin potassium, povidone, glycerol (85%), magnesium stearate, meglumine, and poloxamer. The 1 mg and 2 mg tablets contain iron oxides (yellow and red, respectively) as coloring agents.. SAFETY INFORMATION. Do not use Prandin if you are allergic to repaglinide, if you have type 1 diabetes, or if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin). You should not use Prandin together with gemfibrozil (Lopid) or NPH insulin (such as isophane insulin ...

ATSDR - Chemical Class - Organophosphates and carbamatesATSDR - Chemical Class - Organophosphates and carbamates

Organophosphates and carbamates. Organophosphates are organic compounds that contain phosphorus, while carbamates are salts or ... In different ways, organophosphates and carbamates tend to cause the nervous system to stop working properly. Some are used in ...
more infohttps://www.atsdr.cdc.gov/substances/toxchemicallisting.asp?sysid=39

Isopulegol, carbamateIsopulegol, carbamate

Chromatographic and spectral analysis of terpenes and n-alkyl alcohol carbamates, Anal. Chem., 1973, 45, 2, 376-378. [doi: ...
more infohttps://webbook.nist.gov/cgi/inchi?ID=R579463&Mask=2000

Mixtures of Insecticides: Pyrethroids, Organophosphorus Compounds, and CarbamatesMixtures of Insecticides: Pyrethroids, Organophosphorus Compounds, and Carbamates

... *Framework for Assessing Health Impacts of ... Interaction Profile for Mixtures of Insecticides: Pyrethroids, Organophosphorus Compounds, and Carbamates. (Draft for Public ... Mixtures of Insecticides: Pyrethroids, Organophosphorus Compounds, and Carbamates. ...
more infohttps://www.atsdr.cdc.gov/interactionprofiles/ip15.html

Carbamate Detection  News  on Environmental XPRTCarbamate Detection News on Environmental XPRT

Get the latest carbamate detection news on Environmental XPRT, the worlds largest environmental industry marketplace and ... This test method has been developed by US EPA Region 5 Chicago Regional Laboratory (CRL). The N-methyl carbamate (NMC) ... This test method has been developed by US EPA Region 5 Chicago Regional Laboratory (CRL). The N-methyl carbamate (NMC) ... The N-methyl carbamate (NMC) pesticides: aldicarb, carbaryl, carbofuran, formetanate hydrochloride, methiocarb, methomyl, ...
more infohttps://www.environmental-expert.com/news/keyword-carbamate-detection-12672

Structure for cis-Linalool oxide, carbamateStructure for cis-Linalool oxide, carbamate

... Notes. *This display requires that Java be installed on your system and your ...
more infohttps://webbook.nist.gov/cgi/inchi?Str3View=R579438&Type=Jmol

Transgenic LEP (Vinyl carbamate) M970009Transgenic LEP (Vinyl carbamate) M970009

Testing Status of Transgenic LEP (Vinyl carbamate) M970009. CASRN: 15805-73-9. Formula: C3-H5-N-O2. Synonyms/Common Names. * ...
more infohttps://ntp.niehs.nih.gov/testing/status/agents/ts-m970009.html

Ammonium Carbamate, TCI America™Ammonium Carbamate, TCI America™

ammonium carbamate, ammonium aminoformate, carbamic acid, monoammonium salt, carbamic acid ammonium salt, carbamic acid ... ammonium carbamate, ammonium aminoformate, carbamic acid, monoammonium salt, carbamic acid ammonium salt, carbamic acid ... ammonium carbamate, ammonium aminoformate, carbamic acid, monoammonium salt, carbamic acid ammonium salt, carbamic acid ...
more infohttps://www.fishersci.ca/shop/products/ammonium-carbamate-tci-america-2/p-7124184

US5411967A - Carbamates of rapamycin 
        - Google PatentsUS5411967A - Carbamates of rapamycin - Google Patents

US5411967A - Carbamates of rapamycin - Google Patents. Carbamates of rapamycin Download PDF Info. Publication number. ... Carbamates of rapamycin Patent Citations (2). * Cited by examiner, † Cited by third party. Publication number. Priority date. ... Carbamates of rapamycin Cited By (108). * Cited by examiner, † Cited by third party. Publication number. Priority date. ... Use of aryl carbamates in agriculture and other plant-related areas US9918473B2 (en) 2010-09-01. 2018-03-20. North Carolian ...
more infohttps://patents.google.com/patent/US5411967A/en

Infrared spectra of ammonium carbamate and bicarbonate | SpringerLinkInfrared spectra of ammonium carbamate and bicarbonate | SpringerLink

Galperin, V.A., Finkelshtein, A.I. Infrared spectra of ammonium carbamate and bicarbonate. J Appl Spectrosc 17, 1176-1178 ( ...
more infohttps://link.springer.com/article/10.1007%2FBF00607771

Carbamate - WikipediaCarbamate - Wikipedia

A carbamate is an organic compound derived from carbamic acid (NH2COOH). A carbamate group, carbamate ester (e.g., ethyl ... Carbamate nerve agents While the carbamate acetylcholinesterase inhibitors are commonly referred to as "carbamate insecticides ... Analogues of carbamates with only one of the oxygens replaced by sulfur are called thiocarbamates (2 and 3). Carbamates with ... For example, ammonium carbamate is generated by treatment of ammonia with carbon dioxide 2 NH3 + CO2 → NH4[H2NCO2] Carbamates ...
more infohttps://en.wikipedia.org/wiki/Carbamate

NHANES 2005-2006:
						Pesticides - Carbamates & Organophosphorus Metabolites - Urine Data Documentation, Codebook, and...NHANES 2005-2006: Pesticides - Carbamates & Organophosphorus Metabolites - Urine Data Documentation, Codebook, and...

Pesticides - Carbamates & Organophosphorus Metabolites - Urine (CARB_D) Data File: CARB_D.xpt First Published: February 2013. ... and carbamate metabolites, in particular, AP, MMP, Omet, Dmet, ETU and PTU from a urine matrix. The general sample preparation ... Measures of urinary carbamate and phosphorus pesticides were measured in a one third subsample of persons 6 years and over. ...
more infohttps://wwwn.cdc.gov/Nchs/Nhanes/2005-2006/CARB_D.htm

NHANES 2007-2008:
						Pesticides - Carbamates & Organophosphorus Metabolites - Urine Data Documentation, Codebook, and...NHANES 2007-2008: Pesticides - Carbamates & Organophosphorus Metabolites - Urine Data Documentation, Codebook, and...

Pesticides - Carbamates & Organophosphorus Metabolites - Urine (CARB_E) Data File: CARB_E.xpt First Published: June 2014. Last ... and carbamate metabolites, in particular, AP, MMP, Omet, Dmet, ETU and PTU from a urine matrix. The general sample preparation ... Uurinary carbamate and phosphorus pesticides were measured in a one third subsample of persons 6 years and over. Special sample ...
more infohttps://wwwn.cdc.gov/Nchs/Nhanes/2007-2008/CARB_E.htm

Carbamate kinase - WikipediaCarbamate kinase - Wikipedia

In enzymology, a carbamate kinase (EC 2.7.2.2) is an enzyme that catalyzes the chemical reaction ATP + NH3 + CO2 ⇌ {\ ... The systematic name of this enzyme class is ATP:carbamate phosphotransferase. Other names in common use include CKase, ... Bishop SH, Grisolia S (1966). "Crystalline carbamate kinase". Biochim. Biophys. Acta. 118 (1): 211-5. doi:10.1016/s0926-6593(66 ...
more infohttps://en.wikipedia.org/wiki/Carbamate_kinase

Chemical Database: Carbamate pesticide, liquid, toxic (EnvironmentalChemistry.com)Chemical Database: Carbamate pesticide, liquid, toxic (EnvironmentalChemistry.com)

This page contains information on the chemical Carbamate pesticide, liquid, toxic including: 1 synonyms/identifiers; USDOT 2008 ... Carbamate pesticide, liquid, toxic. Identifications. *Synonyms/Related:*Carbamate pesticide, liquid, toxic. 2008 Emergency ... Carbamate pesticide, liquid, toxic (EnvironmentalChemistry.com),/a,- This page contains information on the chemical Carbamate ... Carbamate pesticide, liquid, toxic. No. No. Related Resources. *USDOT Hazardous Materials Table 49 CFR 172.101. An online ...
more infohttps://environmentalchemistry.com/yogi/chemicals/cn/Carbamate%A0pesticide%2C%A0liquid%2C%A0toxic.html

Review of the existing MRLs for N-methyl-carbamate insecticidesReview of the existing MRLs for N-methyl-carbamate insecticides

... a review of all existing EU MRLs for the N-methyl-carbamate insecticides; carbofuran, carbosulfan, benfuracarb and furathiocarb ...
more infohttp://www.efsa.europa.eu/en/efsajournal/pub/3559

Urinary concentrations of organophosphate and carbamate pesticides inUrinary concentrations of organophosphate and carbamate pesticides in

... residents of a vegetarian community. ... study were to evaluate whether a vegan/vegetarian diet was associated with increased exposure to organophosphate and carbamate ...
more infohttps://www.greenmedinfo.com/article/consumption-organic-produce-may-offer-some-protection-increased-exposure-organ

Contractures produced by carbamate anticholinesterases in bovine tracheal smooth muscle.  - PubMed - NCBIContractures produced by carbamate anticholinesterases in bovine tracheal smooth muscle. - PubMed - NCBI

Contractures produced by carbamate anticholinesterases in bovine tracheal smooth muscle.. Kirkpatrick CT, Rooney PJ. ... 1. In isolated strips of bovine tracheal muscle the carbamate anticholinesterases, neostigmine and eserine caused similar, ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/7166004?dopt=Abstract

US Patent # 4,710,514. Fungicidal carbamates and thiolcarbamates - Patents.comUS Patent # 4,710,514. Fungicidal carbamates and thiolcarbamates - Patents.com

... carbamate), Chlorobufam (1-methyl-2-propynyl N-(3-chlorophenyl)carbamate), Chlorpropham (isopropyl N-(3-chlorophenyl)carbamate ... carbamate, which is disclosed in Monatsch. Chem., Band 57, p.63-70 (1931), and methyl or ethyl N-(3,5-dimethylphenyl) carbamate ... Fungicidal carbamates and thiolcarbamates Abstract. A compound of the formula: ##STR1## useful as a fungicidal agent against ... The residue was purified by recrystallization from toluene to give propargyl N-(3,5-dimethoxyphenyl)carbamate (1.7 g) in a ...
more infohttp://patents.com/us-4710514.html

arcC3 - Carbamate kinase 3 - Staphylococcus aureus (strain USA300) - arcC3 gene & proteinarcC3 - Carbamate kinase 3 - Staphylococcus aureus (strain USA300) - arcC3 gene & protein

Carbamate kinase 2 (arcC2), Carbamate kinase 3 (arcC3), Carbamate kinase 1 (arcC1) ... Carbamate kinase 3 (EC:2.7.2.2*Search proteins in UniProtKB for this EC number. ... Belongs to the carbamate kinase family.Curated. Phylogenomic databases. The HOGENOM Database of Homologous Genes from Fully ... sp,Q2FKJ8,ARCC3_STAA3 Carbamate kinase 3 OS=Staphylococcus aureus (strain USA300) OX=367830 GN=arcC3 PE=3 SV=1 ...
more infohttps://www.uniprot.org/uniprot/Q2FKJ8

Molecules | Free Full-Text | New Water-Soluble Carbamate Ester Derivatives of ResveratrolMolecules | Free Full-Text | New Water-Soluble Carbamate Ester Derivatives of Resveratrol

We report here the synthesis and characterization of carbamate ester derivatives of resveratrol bearing on each nitrogen atom a ... In vivo pharmacokinetics confirmed absorption after oral administration and showed that no hydrolysis of the carbamate groups ... Keywords: resveratrol; prodrugs; carbamate esters; solubility; poly(ethylene glycol); glucose resveratrol; prodrugs; carbamate ... In vivo pharmacokinetics confirmed absorption after oral administration and showed that no hydrolysis of the carbamate groups ...
more infohttp://www.mdpi.com/1420-3049/19/10/15900

IJERPH | Free Full-Text | Carbamate Pesticide-Induced Apoptosis in Human  T LymphocytesIJERPH | Free Full-Text | Carbamate Pesticide-Induced Apoptosis in Human T Lymphocytes

To investigate whether carbamate pesticides also induce apoptosis in human T lymphocytes, in the present study Jurkat human T ... These findings indicate that carbamate pesticides can induce apoptosis in human T cells, and the apoptosis is mediated by the ... We previously found that carbamate pesticides induced significant apoptosis in human natural killer cells. ... Carbamate Pesticide-Induced Apoptosis in Human T Lymphocytes. Qing Li * , Maiko Kobayashi. ...
more infohttp://www.mdpi.com/1660-4601/12/4/3633

Use of aryl carbamates in agriculture and other plant-related areas - North Carolina State UniversityUse of aryl carbamates in agriculture and other plant-related areas - North Carolina State University

... menthyl carbamate. Finally, the cyclohexyl carbamate derivatives of 9a and 10a were prepared as a control (Scheme 3). ... The carbamate heteroatomic core was varied through the substitution with a thiocarbamate, urea, and thiourea linkages. Tail ... When these compounds were tested on S. aureus and MRSA strains, the most potent inhibitors had contained (−)-menthyl carbamates ... The thymyl and carvacryl carbamate analogues of 9a and 10a were also prepared because they had the lowest IC50 values against ...
more infohttp://www.freepatentsonline.com/9439436.html

Carbamate Pesticides in Soil (#879) | ERACarbamate Pesticides in Soil (#879) | ERA

ERA is an accredited provider of Certified Reference Materials, Proficiency Testing and Quality Control Standards for laboratories in the environmental and life sciences markets.
more infohttp://www.eraqc.com/Default.aspx?tabid=86&catalogid=1-4GR6WY&categoryid=1-4GU73G&catalognumber=879

Organophosphate And Carbamate Poisoning - Pipeline Review, H2 2015Organophosphate And Carbamate Poisoning - Pipeline Review, H2 2015

Organophosphate And Carbamate Poisoning - - Market research report and industry analysis - 9384452 ... H2 2015 Organophosphate And Carbamate Poisoning - Pipeline Review, H2 2015 Summary Global Markets Directs, ... Organophosphate And Carbamate Poisoning - Pipeline Products Glance Early Stage Products Organophosphate And Carbamate Poisoning ... Organophosphate And Carbamate Poisoning Overview Therapeutics Development Pipeline Products for Organophosphate And Carbamate ...
more infohttps://www.marketresearch.com/Global-Markets-Direct-v3480/Organophosphate-Carbamate-Poisoning-Pipeline-Review-9384452/

US6184243B1 - N-linked ureas and carbamates of heterocyclic thioesters 
        - Google PatentsUS6184243B1 - N-linked ureas and carbamates of heterocyclic thioesters - Google Patents

This invention relates to neurotrophic low molecular weight, small molecule N-linked ureas and carbamates of heterocyclic ... US6184243B1 - N-linked ureas and carbamates of heterocyclic thioesters - Google Patents. N-linked ureas and carbamates of ... Carbamate and urea compositions and neurotrophic uses EP1082301A1 (en) * 1998-06-03. 2001-03-14. Amgen Inc.. Ureas and ... Novel carbamates and ureas as modifiers of multi-drug resistance US5541191A (en) 1994-06-14. 1996-07-30. American Home Products ...
more infohttps://patents.google.com/patent/US6184243B1/en
  • In enzymology, a carbamate kinase (EC 2.7.2.2) is an enzyme that catalyzes the chemical reaction ATP + NH3 + CO2 ⇌ {\displaystyle \rightleftharpoons } ADP + carbamoyl phosphate The 3 substrates of this enzyme are ATP, NH3, and CO2, whereas its two products are ADP and carbamoyl phosphate. (wikipedia.org)
  • Carbamate kinase catalyzes the reversible reaction of carbamoyl phosphate, ADP to ATP and ammonium phosphate which is then hydrolyzed to ammonia and carbonate. (springer.com)
  • This invention relates to carbamates of rapamycin and a method for using them for inducing immunosuppression, and in the treatment of transplantation rejection, graft vs. host disease, autoimmune diseases, diseases of inflammation, solid tumors, fungal infections, and hyperproliferative vascular disorders. (google.com)
  • Compositions comprising an aryl carbamate compound as described herein in an agriculturally acceptable carrier are also provided, and in some embodiments the compositions further include a microbicide (e.g., including copper, antibiotic, bacteriophage, etc.) and/or a plant defense activator. (freepatentsonline.com)
  • This method is used for determining concentrations of specific organophosphorous and carbamate metabolites, in particular, AP, MMP, Omet, Dmet, ETU and PTU from a urine matrix. (cdc.gov)
  • In essence, these approaches involve the formation of a carbamate anion and its subsequent intramolecular nucleophilic attack on a (pseudo)halide to close the ring. (helsinki.fi)
  • This invention relates to neurotrophic low molecular weight, small molecule N-linked ureas and carbamates of heterocyclic thioesters having an affinity for FKBP-type immunophilins, and their use as inhibitors of the enzyme activity associated with immunophilin proteins, particularly peptidyl-prolyl isomerase, or rotamase, enzyme activity. (google.com)
  • Disclosure is provided for methods of preventing, removing or inhibiting microbial biofilm formation or microbial infection in a plant or plant part thereof, including applying thereto a treatment effective amount of an aryl carbamate as described herein, or an agriculturally acceptable salt thereof. (freepatentsonline.com)
  • The N-terminal amino groups of valine residues in the α- and β-chains of deoxyhemoglobin exist as carbamates. (wikipedia.org)
  • The ε-amino groups of the lysine residues in urease and phosphotriesterase also feature carbamate. (wikipedia.org)
  • Typically, polyurethane polymers are made by combining diisocyanates, e.g. toluene diisocyanate, and diols, where the carbamate groups are formed by reaction of the alcohols with the isocyanates: RN=C=O + R′OH → RNHC(O)OR′ Iodopropynyl butylcarbamate is a wood and paint preservative and used in cosmetics. (wikipedia.org)