Carbamates
Derivatives of carbamic acid, H2NC(=O)OH. Included under this heading are N-substituted and O-substituted carbamic acids. In general carbamate esters are referred to as urethanes, and polymers that include repeating units of carbamate are referred to as POLYURETHANES. Note however that polyurethanes are derived from the polymerization of ISOCYANATES and the singular term URETHANE refers to the ethyl ester of carbamic acid.
Urethane
Insecticides
Carbaryl
Phosphotransferases (Carboxyl Group Acceptor)
Carbofuran
Cholinesterase Inhibitors
Drugs that inhibit cholinesterases. The neurotransmitter ACETYLCHOLINE is rapidly hydrolyzed, and thereby inactivated, by cholinesterases. When cholinesterases are inhibited, the action of endogenously released acetylcholine at cholinergic synapses is potentiated. Cholinesterase inhibitors are widely used clinically for their potentiation of cholinergic inputs to the gastrointestinal tract and urinary bladder, the eye, and skeletal muscles; they are also used for their effects on the heart and the central nervous system.
Acetylcholinesterase
Phenylcarbamates
Pesticides
Carbamyl Phosphate
Chlorphenesin
Pesticide Residues
Organophosphate Poisoning
Pyrethrins
Organophosphates
Carbon-containing phosphoric acid derivatives. Included under this heading are compounds that have CARBON atoms bound to one or more OXYGEN atoms of the P(=O)(O)3 structure. Note that several specific classes of endogenous phosphorus-containing compounds such as NUCLEOTIDES; PHOSPHOLIPIDS; and PHOSPHOPROTEINS are listed elsewhere.
Carboxylesterase
Houseflies
Organophosphorus Compounds
Fungicides, Industrial
Prodrugs
Molecular Structure
Anopheles gambiae
Physostigmine
Ornithine Carbamoyltransferase
Enzyme Reactivators
Carbonates
Carboxylic Ester Hydrolases
DDT
A polychlorinated pesticide that is resistant to destruction by light and oxidation. Its unusual stability has resulted in difficulties in residue removal from water, soil, and foodstuffs. This substance may reasonably be anticipated to be a carcinogen: Fourth Annual Report on Carcinogens (NTP-85-002, 1985). (From Merck Index, 11th ed)
Stereoisomerism
Safrole
Hydrolases
Any member of the class of enzymes that catalyze the cleavage of the substrate and the addition of water to the resulting molecules, e.g., ESTERASES, glycosidases (GLYCOSIDE HYDROLASES), lipases, NUCLEOTIDASES, peptidases (PEPTIDE HYDROLASES), and phosphatases (PHOSPHORIC MONOESTER HYDROLASES). EC 3.
Structure-Activity Relationship
Dieldrin
Biotransformation
The chemical alteration of an exogenous substance by or in a biological system. The alteration may inactivate the compound or it may result in the production of an active metabolite of an inactive parent compound. The alterations may be divided into METABOLIC DETOXICATION, PHASE I and METABOLIC DETOXICATION, PHASE II.
Monoacylglycerol Lipases
Croton Oil
Combinatorial Chemistry Techniques
Fumigation
Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing)
Organothiophosphorus Compounds
Methanosarcina barkeri
Herbicides
Trifluoroacetic Acid
Mosquito Control
Sterol Esterase
Ethylene Oxide
A colorless and flammable gas at room temperature and pressure. Ethylene oxide is a bactericidal, fungicidal, and sporicidal disinfectant. It is effective against most micro-organisms, including viruses. It is used as a fumigant for foodstuffs and textiles and as an agent for the gaseous sterilization of heat-labile pharmaceutical and surgical materials. (From Reynolds, Martindale The Extra Pharmacopoeia, 30th ed, p794)
Involvement of two plasmids in the degradation of carbaryl by Arthrobacter sp. strain RC100. (1/1210)
A bacterium capable of utilizing carbaryl (1-naphthyl N-methylcarbamate) as the sole carbon source was isolated from carbaryl-treated soil. This bacterium was characterized taxonomically as Arthrobacter and was designated strain RC100. RC100 hydrolyzes the N-methylcarbamate linkage to 1-naphthol, which was further metabolized via salicylate and gentisate. Strain RC100 harbored three plasmids (designated pRC1, pRC2, and pRC3). Mutants unable to degrade carbaryl arose at a high frequency after treating the culture with mitomycin C. All carbaryl-hydrolysis-deficient mutants (Cah-) lacked pRC1, and all 1-naphthol-utilization-deficient mutants (Nat-) lacked pRC2. The plasmid-free strain RC107 grew on gentisate as a carbon source. These two plasmids could be transferred to Cah- mutants or Nat- mutants by conjugation, resulting in the restoration of the Cah and Nah phenotypes. (+info)Efficacy and safety of rivastigmine in patients with Alzheimer's disease: international randomised controlled trial. (2/1210)
OBJECTIVES: To assess the effects of rivastigmine on the core domains of Alzheimer's disease. DESIGN: Prospective, randomised, multicentre, double blind, placebo controlled, parallel group trial. Patients received either placebo, 1-4 mg/day (lower dose) rivastigmine, or 6-12 mg/day (higher dose) rivastigmine. Doses were increased in one of two fixed dose ranges (1-4 mg/day or 6-12 mg/day) over the first 12 weeks with a subsequent assessment period of 14 weeks. SETTING: 45 centres in Europe and North America. PARTICIPANTS: 725 patients with mild to moderately severe probable Alzheimer's disease diagnosed according to the Diagnostic and Statistical Manual of Mental Disorders, fourth edition, and the criteria of the National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer's Disease and Related Disorders Association. OUTCOME MEASURES: Cognitive subscale of the Alzheimer's disease assessment scale, rating on the clinician interview based impression of change incorporating caregiver information scale, and the progressive deterioration scale. RESULTS: At the end of the study cognitive function had deteriorated among those in the placebo group. Scores on the Alzheimer's disease assessment scale improved in patients in the higher dose group when compared with patients taking placebo (P<0.05). Significantly more patients in the higher dose group had improved by 4 points or more than had improved in the placebo group (24% (57/242) v 16% (39/238)). Global function as rated by the clinician interview scale had significantly improved among those in the higher dose group compared with those taking placebo (P<0.001), and significantly more patients in the higher dose group showed improvement than did in the placebo group (37% (80/219) v 20% (46/230)). Mean scores on the progressive deterioration scale improved from baseline in patients in the higher dose group but fell in the placebo group. Adverse events were predominantly gastrointestinal, of mild to moderate severity, transient, and occurred mainly during escalation of the dose. 23% (55/242) of those in the higher dose group, 7% (18/242) of those in the lower dose group, and 7% (16/239) of those in the placebo group discontinued treatment because of adverse events. CONCLUSIONS: Rivastigmine is well tolerated and effective. It improves cognition, participation in activities of daily living, and global evaluation ratings in patients with mild to moderately severe Alzheimer's disease. This is the first treatment to show compelling evidence of efficacy in a predominantly European population. (+info)Treatment with amprenavir alone or amprenavir with zidovudine and lamivudine in adults with human immunodeficiency virus infection. AIDS Clinical Trials Group 347 Study Team. (3/1210)
Amprenavir is a human immunodeficiency virus (HIV) protease inhibitor with a favorable pharmacokinetic profile and good in vitro activity. Ninety-two lamivudine- and protease inhibitor-naive individuals with >/=50 CD4 cells/mm3 and >/=5000 HIV RNA copies/mL were assigned amprenavir (1200 mg) alone or with zidovudine (300 mg) plus lamivudine (150 mg), all given every 12 h. After a median follow-up of 88 days, the findings of a planned interim review resulted in termination of the amprenavir monotherapy arm. Among 85 subjects with confirmed plasma HIV RNA determination, 15 of 42 monotherapy versus 1 of 43 triple-therapy subjects had an HIV RNA increase above baseline or 1 log10 above nadir (P=.0001). For subjects taking triple therapy at 24 weeks, the median decrease in HIV RNA was 2.04 log10 copies/mL, and 17 (63%) of 27 evaluable subjects had <500 HIV RNA copies/mL. Treatment with amprenavir, zidovudine, and lamivudine together reduced the levels of HIV RNA significantly more than did amprenavir monotherapy. (+info)A 1-year multicenter randomized double-blind comparison of repaglinide and glyburide for the treatment of type 2 diabetes. Dutch and German Repaglinide Study Group. (4/1210)
OBJECTIVE: Repaglinide is a newly developed oral blood glucose-lowering agent that exerts its effect by stimulating insulin secretion. This multicenter study was designed to compare the efficacy and safety of this drug with glyburide in a 1-year randomized double-blind study of outpatients with type 2 diabetes. RESEARCH DESIGN AND METHODS: A total of 424 subjects (154 women, 270 men) participated and had the following characteristics: age, 61 +/- 9 years; duration of diabetes. 8 years (range 0.5-35); BMI, 28.3 +/- 3.5 kg/m2; HbA1c, 7.1 +/- 1.4%; and fasting plasma glucose, 10.8 +/- 3.1 mmol/l. The majority of the subjects (91%) were previously treated with sulfonylurea, alone or in combination with metformin. The patients were randomized to a 2:1 ratio of repaglinide (0.5-4 mg t.i.d.) or glyburide (1.75-10.5 mg daily) treatment. The study protocol included a screening visit to assess patient eligibility; a titration period of 6-8 weeks, during which the dosages of repaglinide and glyburide were optimized; and a subsequent 12-month treatment period on fixed, optimal dosages. RESULTS: The trial was completed by 320 subjects, 211 (74%) in the repaglinide and 109 (78%) in the glyburide group. HbA1c initially decreased in both groups and then increased during the second half-year of the maintenance period to a similar extent in the repaglinide and glyburide subjects (0.58 and 0.45% vs. at screening, respectively). In the small group of subjects who previously controlled their condition with diet only (n = 37), a sustained improvement of metabolic control could be observed with both drugs, which was slightly better with glyburide than with repaglinide (theta HbA1c -2.4 vs. -1.0%; P < 0.05). The same trends were seen with fasting plasma glucose. There were no changes in serum lipids. Over the course of the study, 15% of the repaglinide-treated and 13% of glyburide-treated subjects withdrew due to adverse events, mostly hyperglycemia. No differences in adverse events between both drugs were reported. There were no differences in incidences of hypoglycemia. CONCLUSIONS: Repaglinide is a safe and efficacious oral blood glucose-lowering agent, with a potency similar to that of glyburide. Its rapid onset of action and hepatic clearance allows meal-related administration, including in subjects with impaired kidney function. (+info)Structural and mechanistic aspects of transcriptional induction of cytochrome P450 1A1 by benzimidazole derivatives in rat hepatoma H4IIE cells. (5/1210)
The effect of several structurally different benzimidazole compounds on CYP1A1 expression at the transcriptional, mRNA and protein levels was investigated in the rat hepatoma H4IIE cell line. Omeprazole, thiabendazole, carbendazim, 2-mercaptobenzimidazole and 2-mercapto-5-methoxybenzimidazole caused a dose-dependent increase in CYP1A1 protein levels that reached maximum effect at 250 microm, as measured by Western blot. In addition, hydroxyomeprazole, 2-aminobenzimidazole and 2-mercapto-5-nitro-benzimidazole caused a notable increase in CYP1A1 protein expression, whereas 5-O-desmethylomeprazole, 2-hydroxybenzimidazole, 2-benzimidazole propionic acid and 5-benzimidazole carboxylic acid were ineffective. Thus, benzimidazole substituted with a thiol or an amino group in the 2-position were active inducers. Northern blot analysis confirmed an extensive increase of CYP1A1 mRNA induced by omeprazole and 2-mercapto-5-methoxybenzimidazole which was 32% and 49% of maximal induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) respectively, whereas thiabendazole and carbendazim showed approximately 15% increase as compared to TCDD. Transient transfection of H4IIE cells, with a XRE-pGL3 reporter gene construct revealed a 2.3-4.3-fold induction by carbendazim, thiabendazole, and 2-mercapto-5-methoxybenzimidazole as compared to a 3.3- and 23-fold induction by omeprazole and TCDD, respectively. Thus, these data indicate that the benzimidazoles utilize the aryl hydrocarbon receptor-arnt-XRE-mediated signal-transduction pathway for induction of the CYP1A1 gene. (+info)A common pharmacophore for cytotoxic natural products that stabilize microtubules. (6/1210)
Taxol (paclitaxel), a complex diterpene obtained from the Pacific yew, Taxus brevifolia, is arguably the most important new drug in cancer chemotherapy. The mechanism of cytotoxic action for paclitaxel-i.e., the stabilization of microtubules leading to mitotic arrest-is now shared by four recently identified natural products, eleutherobin, epothilones A and B, and discodermolide. Their ability to competitively inhibit [3H]paclitaxel binding to microtubules strongly suggests the existence of a common binding site. Recently, we have developed nonaromatic analogues of paclitaxel that maintain high cytotoxicity and tubulin binding (e.g., nonataxel). We now propose a common pharmacophore that unites paclitaxel, nonataxel, the epothilones, eleutherobin, and discodermolide, and rationalizes the extensive structure-activity relationship data pertinent to these compounds. Insights from the common pharmacophore have enabled the development of a hybrid construct with demonstrated cytotoxic and tubulin-binding activity. (+info)Pharmacological activities of TEI-8362, a novel inhibitor of human neutrophil elastase. (7/1210)
1. TEI-8362, 4-(N-(3-((3-carboxypropyl)amino)-8-methyl-1-oxo-4-azaisochromen-6- yl)carbamoyl)-4-((phenylmethoxy)carbonylamino)butanoic acid (C26H28N4O9) is a novel inhibitor of human neutrophil elastase (HNE). We evaluated its pharmacological profile in vitro and in vivo. 2. TEI-8362 demonstrated potent inhibition of HNE with a Ki value of 1.38 x 10(-9) M. Its selectivity for HNE among a variety of proteases ranged from 163 fold to 68,000 fold in favour of HNE. 3. The pulmonary haemorrhage that occurred after i.t. instillation of HNE to hamsters was inhibited by either i.t., i.v., or inhalant administration of TEI-8362. 4. Intratracheal administration of lipopolysaccharide induced pulmonary neutrophilia. Twenty-four hours after lipopolysaccharide administration, the additional treatment with formyl-methionyl-leucyl-phenylalanine resulted in a specific neutrophil-dependent acute lung injury. In this model, lung injury was significantly attenuated by i.t., i.v., or inhalant administration of TEI-8362. 5. These pharmacological actions of TEI-8362 suggest that this drug has therapeutic value in the treatment of destructive lung diseases due to neutrophils. (+info)Does an association between pesticide use and subsequent declines in catch of Atlantic salmon (Salmo salar) represent a case of endocrine disruption? (8/1210)
Historical aerial applications of the insecticide Matacil 1.8D provide an opportunity to look for potential effects of the endocrine disrupting compound 4-nonylphenol (4-NP) on Atlantic salmon (Salmo salar) populations. Matacil 1.8D contained the carbamate insecticide aminocarb, with 4-NP as primary solvent. Between 1975 and 1985 Matacil 1.8D was applied to forests in Atlantic Canada to control damage from the spruce budworm (Choristoneura fumiferana). After spraying, estimated concentrations of 4-NP in water fell within a range in which estrogenic effects might be anticipated. The spraying coincided with final stages of smolt development in salmon. Salmon catch data were evaluated considering effects on survival of the smolt stage. There was a significant negative relationship between the returns of salmon and the proportion of tributaries sprayed within the Restigouche River drainage basin in 1977. There was also a broader event of unusually heavy salmon smolt mortality in 1977, which contains a significant relationship indicating that where Matacil 1.8D spraying occurred, the smolt mortality increased. For 16 rivers exposed to spraying between 1973 and 1990, a significant proportion (p<0.005) of the lowest salmon catches coincided with Matacil 1.8D spraying. A decline coinciding with the use of Matacil 1.8D was also apparent in blueback herring (Alosa aestivalis) catches in New Brunswick. Because similar relationships were not evident for Matacil 1.8F or fenitrothion, neither of which were formulated with 4-NP, we hypothesize that the 4-NP in Matacil 1.8D was the causal agent. Concentrations of 4-NP described here are within current ranges encountered in industrial effluents and municipal sewage outfalls. (+info)
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EA-3990
Carbamates like EA-3990 are well absorbed by the lungs, gastrointestinal tracts, and the skin. Signs and symptoms from exposure ... EA-3990 is a deadly carbamate nerve agent. It is lethal because it inhibits acetylcholinesterase. Inhibition causes an overly ... "Carbamates". Handbook of toxicology of chemical warfare agents (2nd ed.). Amsterdam: Elsevier/Academic Press. pp. 338-339. ISBN ... Carbamate nerve agents, Pyridines, Quaternary ammonium compounds, Bromides, Acetylcholinesterase inhibitors, Biscarbamates, ...
Aminocarb
Carbamate insecticides, Anilines, Aromatic carbamates, Phenol esters, Dimethylamino compounds). ... Aminocarb is a carbamate insecticide widely used to protect cotton fields, crop fields, and forests from insect infestation. It ... ISBN 978-1-4398-2060-5. Aizawa, Hiroyasu (2001). "Carbamates". Metabolic Maps. pp. 74-81. doi:10.1016/B978-012045605-5/50007-6 ...
EA-4056
Carbamates like EA-4056 are well absorbed by the lungs, gastrointestinal tracts, and the skin. Signs and symptoms from exposure ... EA-4056 is a deadly carbamate nerve agent. It is lethal because it inhibits acetylcholinesterase. Inhibition causes an overly ... "Carbamates". Handbook of toxicology of chemical warfare agents (2nd ed.). Amsterdam: Elsevier/Academic Press. pp. 338-339. ISBN ... Carbamate nerve agents, Pyridines, Quaternary ammonium compounds, Bromides, Acetylcholinesterase inhibitors, Biscarbamates, ...
Carbamic acid
Carbamate is also a term used for esters of carbamic acids, such as methyl carbamate H2N−C(=O)−OCH3. The carbamoyl functional ... Methyl carbamate and ethyl carbamate are among the simplest examples and have historically been used in the textile industry, ... Benzyl carbamate is also known. The enzyme carbamate kinase, involved in several metabolic pathways of living organisms, ... carbamic acids carbamate anions carbamate esters carbamoyl chlorides Many substituted carbamic acids (RHNCOOH or RR′NCOOH), can ...
Dimethylcarbamoyl chloride
DMCC is a starting material for the insecticide class of the dimethyl carbamates which act as inhibitors of ... De Cusati, P. F.; Olofson, R. A. (1990). "A simple synthesis of 1-(1,3-butadienyl)carbonates and carbamates". Tetrahedron ... Unsaturated conjugated aldehydes such as crotonaldehyde (trans-but-2-enal) react with DMCC forming dienyl carbamates, which can ... Jäger, P.; Rentzea, C. N.; Kieczka, H. (2014). "Carbamates and carbamoyl chloride". Ullmann's Fine Chemicals. Weinheim: Wiley- ...
Depressant
Carbamates are a class of depressants or "tranquilizers" that are synthesized from urea. Carbamates have anxiolytic, muscle ... Carbamates are fatal in overdose, which is why a lot of them have been replaced with benzodiazepines. It is not recommended to ... Carbamates we're popular in the 1950's along with barbiturates. Although they have been slowly phased out; mainly due to the ... Some carbamates block sodium channels. Phenprobamate was used as an anxiolytic and is still sometimes used in Europe for ...
List of withdrawn drugs
"Ethyl carbamate". Archived from the original on 27 September 2013. Retrieved 24 September 2013. DrugBank. "Fenfluramine". ...
Chlorosulfonyl isocyanate
Conversion of primary alcohols to carbamates. Conversion of carboxylic acids and the acid chlorides into nitriles. Preparation ...
Peachester Public Dip
... and carbamates. Research undertaken by C.J. Pound and later the Commonwealth Scientific and Industrial Research Organisation ( ...
Enzyme inhibitor
The carbamate pesticides are also examples of reversible AChE inhibitors. The organophosphate pesticides such as malathion, ... ISBN 978-1-00-009898-3. Gupta RC (2006). "Classification and Uses of Organophosphates and Carbamates". In Gupta RC (ed.). ... Kuhr RJ, Dorough HW (1976). Carbamate Insecticides: Chemistry, Biochemistry, and Toxicology. Cleveland: CRC Press. ISBN 978-0- ... Toxicology of Organophosphate and Carbamate Compounds. Amsterdam: Elsevier Academic Press. pp. 5-24. ISBN 978-0-08-054310-9. ...
Phenyl isocyanate
Similarly, reacts with alcohols to form carbamates. It is used in addition with triethylamine to activate nitro groups to ...
Dermanyssus gallinae
Organophosphates, carbamates, and pyrethroids are widely used. The first case of pyrethroid resistance was reported by Beugnet ...
Methocarbamol
... is the carbamate derivative of guaifenesin, but does not produce guaifenesin as a metabolite, because the ... Unlike other carbamates such as meprobamate and its prodrug carisoprodol, methocarbamol has greatly reduced abuse potential. ... All the major metabolites are unhydrolyzed carbamates. Small amounts of unchanged methocarbamol are also excreted in the urine ... Alternatively, methocarbamol may act via inhibition of acetylcholinesterase, similarly to carbamate. In healthy individuals, ...
Organophosphate poisoning
Carbamate poisoning can present similarly. Prevention efforts include banning very toxic types of organophosphates. Among those ... Toxicity, Organophosphate and Carbamate at eMedicine Moore C (2009). Children and Pollution: Why Scientists Disagree. Oxford ... Current antidotes for OP poisoning consist of a pretreatment with carbamates to protect AChE from inhibition by OP compounds ... Leibson T, Lifshitz M (2008). "Organophosphate and Carbamate Poisoning: Review of the Current Literature and Summary of ...
Urea
... then recombining the resultant carbon dioxide and ammonia in a falling-film carbamate condenser and pumping the carbamate ... The first is carbamate formation: the fast exothermic reaction of liquid ammonia with gaseous carbon dioxide (CO2) at high ... The second is the amount of water recycled in the carbamate solution, which has an adverse effect on the equilibrium in the ... In early "straight-through" urea plants this was done by letting down the system pressure to atmospheric to let the carbamate ...
Chlorfenvinphos
King, Andrew M.; Aaron, Cynthia K. (February 2015). "Organophosphate and Carbamate Poisoning". Emergency Medicine Clinics of ...
Pesticide
Organophosphate and carbamate insecticides have a similar mode of action. They affect the nervous system of target pests (and ... In general, a pesticide is a chemical (such as carbamate) or biological agent (such as a virus, bacterium, or fungus) that ... Chlorinates such as DDT were dominant, but they were replaced in the U.S. by organophosphates and carbamates by 1975. Since ... Organophosphates are quite toxic to vertebrates and have in some cases been replaced by less toxic carbamates.: 136-137 ...
Allophanic acid
Allophonate esters arise from the condensation of carbamates. Karachinskii, S. V.; Dragalov, V. V.; Chimishkyan, A. L.; ...
TMC-310911
Ghosh AK, Brindisi M (April 2015). "Organic carbamates in drug design and medicinal chemistry". Journal of Medicinal Chemistry ...
GABAA receptor
Positive allosteric modulators: barbiturates, benzodiazepines, certain carbamates (ex. carisoprodol, meprobamate, lorbamate), ...
Pesticide poisoning
If one is regularly using carbamate and organophosphate pesticides, it is important to obtain a baseline cholinesterase test. ... Gupta RC (28 April 2011). Toxicology of Organophosphate & Carbamate Compounds. Academic Press. pp. 352-353. ISBN 978-0-08- ... carbamates, and anticholinesterases, are most commonly reported in occupationally related pesticide poisonings globally. ...
Cholinesterase inhibitor
Organophosphate and carbamate Institute, National; (UK), Care Excellence (2019-12-27). Cholinesterase inhibitors and memantine ...
Butocarboxim
... is a carbamate insecticide. It is a structural isomer of aldicarb. Carbamate insecticide Aldicarb Aharonson, N; ... Carbamate insecticides, Oxime carbamates, Thioethers, Acetylcholinesterase inhibitors, All stub articles, Organic compound ...
Fenobucarb
Carbamate insecticides, Phenol esters, Aromatic carbamates, All stub articles, Organic compound stubs). ... Fenobucarb is a carbamate insecticide, also widely known as BPMC. A pale yellow or pale red liquid, insoluble in water; used as ... "N-Methyl Carbamate Insecticides" (PDF). Oregon State University. v t e (ECHA InfoCard ID from Wikidata, Pages using collapsible ... N-methyl o-sec-butylphenyl carbamate Fenobucarb, Osbac, Bassa, Bipvin, Baycarb, etc Male Mouse 340 mg/kg Male Rat 410 mg/kg ...
Oxamyl
... is a carbamate pesticide. According to the WHO Food and Agriculture Organization, "Oxamyl is a colourless crystalline ...
Juvenile-hormone esterase
... carbamate insecticides were also tested. By far the most potent inhibitor was an ethoxythiophenylphospamidothiolate, with IC50 ...
Flavin-containing monooxygenase 3
... such as organophosphates and carbamates [14-22]. Cashman JR (September 2000). "Human flavin-containing monooxygenase: substrate ...
Heteroatom-promoted lateral lithiation
5) Related O-aryl carbamates are good directing groups; upon warming, the resulting organolithiums undergo rearrangement to ... 6) Secondary N-aryl carbamates (along with secondary amides, ketones, and other directing groups containing acidic hydrogens) ... carbamates, and sulfonates. Lateral lithiation of alkyl-substituted heterocycles incorporating heteroatom-containing ...
Photolabile protecting group
Overall, phenacyl PPGs can be used to protect sulfonates, phosphates, carboxylates and carbamates. As with nitrobenzyl-based ... carbamates, thiolates, phenolates and alkoxides. Additionally, while the rate varies with a number of variables, including ... this substitution is only able to release good leaving groups such as carbamates and carboxylates. Additionally, the addition ... "Photogeneration of Organic Bases from o-Nitrobenzyl-Derived Carbamates". Journal of the American Chemical Society. 113 (11): ...
Albendazole
... carbamate, methyl [5-(n-propylsulfinyl)-1H-benzimidazole-2-yl)] carbamate, 5-(n-propylsulfonyl)-1H-benzimidazole-2-yl amine, ... The major final metabolites that are excreted by humans are: methyl [5-(propylsulfonyl-1H-benzimidazol-2-yl)] carbamate, methyl ... It is, however, better absorbed than other benzimidazole carbamates. Food stimulates gastric acid secretion, lowering the pH ... Carbamates, Thioethers, World Health Organization essential medicines, Wikipedia medicine articles ready to translate). ...
Organophosphates and carbamates | Chemical Classifications | Toxic Substance Portal | ATSDR
Mixtures of Insecticides: Pyrethroids, Organophosphorus Compounds, and Carbamates
Carbamate - Wikipedia
... as well as salts with the carbamate anion H2NCOO− (e.g. ammonium carbamate). Polymers whose units are joined by carbamate ... Analogues of carbamates with only one of the oxygens replaced by sulfur are called thiocarbamates (2 and 3). Carbamates with ... The salt ammonium carbamate is generated by treatment of ammonia with carbon dioxide: 2 NH3 + CO2 → NH4[H2NCO2] Carbamate ... While carbamic acids are unstable, many carbamate esters or ionic) are stable and well known. In water solutions, the carbamate ...
Multicentre clinical trials of benzimidazole-carbamates in human cystic echinococcosis (phase 2).
CISDOC - Neurotoxicologic studies of two carbamate pesticides in subacute animal experiments.
Phenyl benzyl(methyl)carbamate | C15H15NO2 | ChemSpider
Vinyl Carbamate | GreenMedInfo | Toxic Ingredient | Natural Medicine
Additional Keywords : Beet, Benzo(a)pyrene, Betaine, lung cancer, Vinyl Carbamate. Problem Substances : Benzo(a)pyrene, Vinyl ... Both indole-3-carbinol and myo-inositol inhibit the development of vinyl carbamate induced pulmonary adenocarcinoma in mice.Jan ... 2 Abstracts with Vinyl Carbamate Research. Filter by Study Type. Animal Study. ...
Carbamate - National Diagnostics
Validation of Carbamate Pesticide Screen for VETLIRN Network | National Agricultural Library
Validation of Carbamate Pesticide Screen for VETLIRN Network Validation of Carbamate Pesticide Screen for VETLIRN Network. ... Carbamates are highly toxic insecticides, with current pesticide use registrations. They are found both in agricultural and ... that within the first three years of funding we will validate the performance of a qualitative screening method for carbamate ...
Re-evaluation Note REV2021-01, Project Plan for Cumulative Health Risk Assessment - N-Methyl Carbamates - Canada.ca
The re-evaluation project plan outlines the timelines for the cumulative risk assessment of the N-methyl carbamate pesticides. ... As outlined in Re-evaluation Note REV2018-17, Initiation of Cumulative Health Risk Assessment - N-Methyl Carbamates, the NMC ... In Canada, an assessment of the cumulative health risks for active ingredients belonging to the N-methyl carbamate (NMC) class ... Re-evaluation Note REV2021-01, Project Plan for Cumulative Health Risk Assessment - N-Methyl Carbamates. ...
Carbamates on Ultra Carbamate
Flea & Tick Control (Carbamate) - dogs - Lort Smith Animal Hospital
Home / Need help now? / First Aid for dogs / Poisons & Toxins / Medication & Drugs / Flea & Tick Control (Carbamate) - dogs ... Junquera P (2013) Carbamates for veterinary use on livestock, viewed 15/11/13, from parasitipedia.net… ... Carbamate insecticides cause nerves/neurons to remain in constant activity and excitation. ... Blodgett DJ (2006) Organophosphate and Carbamate Insecticides In: Small Animal Toxicology. 2ndEdn. Peterson ME & Talcott PA. ...
WHO EMRO | Findings of the WHO EMRO Pediatric Insecticide Study Group on organophosphate / carbamate poisoning in children...
Findings of the WHO EMRO Pediatric Insecticide Study Group on organophosphate / carbamate poisoning in children published ... carbamates, identifying those requiring referral to higher level facilities. The decision aid for referral, which is in line ... "A clinical decision aid for triage of children younger than 5 years and with organophosphate or carbamate insecticide exposure ...
British Library EThOS: Development of a technology for the discovery of protein carbamates
Development of a technology for the discovery of protein carbamates Author: Linthwaite, Victoria Louise ISNI: 0000 0004 6059 ... Carbamates are labile and previous work on this PTM has involved their study under non-physiological conditions. The objective ... The carbamate modification has been observed on proteins including RuBisCO and haemoglobin but remains largely unexplored as a ... This methodology provides a technology to identify sites of carbamate formation and will permit the identification of sites of ...
RCSB PDB - 1E19: Structure of the carbamate kinase-like carbamoyl phosphate synthetase from the hyperthermophilic archaeon...
Structure of the carbamate kinase-like carbamoyl phosphate synthetase from the hyperthermophilic archaeon Pyrococcus furiosus ... The last step, the phosphorylation of carbamate, is also catalyzed by carbamate kinase (CK), an enzyme used by microorganisms ... The last step, the phosphorylation of carbamate, is also catalyzed by carbamate kinase (CK), an enzyme used by microorganisms ... CARBAMATE KINASE. A, B. 314. Pyrococcus furiosus. Mutation(s): 0 EC: 2.7.2.2. ...
9H-Fluoren-9-yl)methyl ((2R,3R)-3-(tert-butoxy)-1-hydroxybutan-2-yl)carbamate | C23H29NO4 - PubChem
Carbamates--Environmental aspects
Influence of must nitrogen addition on ethyl carbamate formation by lactic acid bacteria | Viticulture and Enology
... these authors artificially enriched Tempranillo juices and then evaluated whether ethyl carbamate had increased beyond levels ... might enhance the formation of the cancerigenous compound ethyl carbamate, ... Influence of must nitrogen addition on ethyl carbamate formation by lactic acid bacteria ... Influence of must nitrogen addition on ethyl carbamate formation by lactic acid bacteria ...
5-[(3,5-Dichlorophenyl)sulfanyl]-4-isopropyl-1-(3-quinolinylmethyl)-1H-imidazol-2-yl}methyl carbamate | C24H22Cl2N4O2S |...
carbamate (ester) [ACD/Index Name] Carbamate de {5-[(3. ,5-dichlorophényl)s. ulfanyl]-4-isopropy. l-1-(3-quinoléinylm. éthyl)- ... carbamate (ester) 1H-IMIDAZOLE-2-METH. ANOL,5-[(3,5-DICHLO. ROPHENYL)THIO]-4-(1. -METHYLETHYL)-1-(3-. QUINOLINYLMETHYL)-,. ... yl carbamate *Molecular FormulaC24H22Cl2N4O2S ...
Cyclic amides (including cyclic carbamates) and their derivatives; n.e.s. in item no. 2924.2 exports to Cyprus |2018
In 2018, Top exporters of Cyclic amides (including cyclic carbamates) and their derivatives; n.e.s. in item no. 2924.2 to ... HS Code 292429: Cyclic amides (including cyclic carbamates) and their derivatives; n.e.s. in item no. 2924.2. Please note: ... Cyclic amides (including cyclic carbamates) and their derivatives; n.e.s. in item no. 2924.2. 2018. Cyprus. 87.81. 13,520. Kg. ... Cyclic amides (including cyclic carbamates) and their derivatives; n.e.s. in item no. 2924.2. 2018. Cyprus. 2,866.83. 6,904. Kg ...
Methyl (3,5-dichlorophenyl)carbamate [25217-43-0], Information for Methyl (3,5-dichlorophenyl)carbamate [25217-43-0], Suppliers...
... carbamate [25217-43-0] CAS NO 25217-43-0, Methyl (3,5-dichlorophenyl)carbamate [25217-43-0] Suppliers, Methyl (3,5- ... dichlorophenyl)carbamate [25217-43-0] Manufacturers, related products of Methyl (3,5-dichlorophenyl)carbamate [25217-43-0]. ... About Methyl (3,5-dichlorophenyl)carbamate [25217-43-0]. Powerd by ChemNet Methyl (3,5-dichlorophenyl)carbamate [25217-43-0]. ... Methyl (3,5-dichlorophenyl)carbamate. Synonyms:. 3,5-Dichlorocarbanilic acid methyl ester; BRN 2101855; MDPC; Methyl 3,5- ...
Benfuracarb, see CARBAMATE PESTICIDE - HNS Convention
China Tert-butyl N-[(4-formylphenyl)methyl]Carbamate, China 2,4-Dibromothiazole, China Benzyl 4-bromobutyl ether, Products...
Comparative Assessment of the Activity of Decoquinate and Its Quinoline-O-Carbamate Derivatives against Toxoplasma gondii in...
Thus, three quinoline-O-carbamate derivatives of DCQ antici-pated to have better physicochemical properties than DCQ were ... Comparative Assessment of the Activity of Decoquinate and Its Quinoline-O-Carbamate Derivatives against Toxoplasma gondii in ... Thus, three quinoline-O-carbamate derivatives of DCQ antici-pated to have better physicochemical properties than DCQ were ... O-Carbamate Derivatives Against Toxoplasma gondii In Vitro and in Pregnant Mice Infected with T. gondii Oocysts. Molecules 2021 ...
US Patent for 3-Pyridylmethyl-(N-substituted phenyl)-carbamate derivatives Patent (Patent # 4,033,972 issued July 5, 1977) -...
This is particularly true for such carbamates having two substituents on the carbamate nitrogen. Normally only single ... Justia Patents US Patent for 3-Pyridylmethyl-(N-substituted phenyl)-carbamate derivatives Patent (Patent # 4,033,972) 3- ... the carbamates of this invention can be converted to novel acid salts with a strong inorganic or organic acid. Typical strong ... The carbamates of this invention react with metal salts in solution to give metal salt complexes. Typical salts which react in ...
Probabilistic cumulative dietary exposure assessment for Danish consumers to organophosphorus and carbamate pesticides
-...
Biomonitoring Summary | CDC
Carbamate Insecticides Overview. General Information N-methyl carbamate insecticides (carbamates) have been widely used in the ... Carbamates have been used on residential lawns, ornamentals, in nurseries, and on golf courses. Carbamates do not persist in ... Carbamate insecticides are rapidly eliminated from the body. In the National Biomonitoring Program, two carbamate metabolites ... The mechanism of toxicity of carbamate insecticides is similar to organophosphate pesticides; however, carbamate insecticides ...
Details for:
Some carbamates, thiocarbamates and carbazides /
› WHO HQ Library catalog
KOPS.Rapid Labeling of Metabolically Engineered Cell-Surface Glycoconjugates with a Carbamate-Linked Cyclopropene Reporter
Rapid Labeling of Metabolically Engineered Cell-Surface Glycoconjugates with a Carbamate-Linked Cyclopropene Reporter. * Home ... Rapid Labeling of Metabolically Engineered Cell-Surface Glycoconjugates with a Carbamate-Linked Cyclopropene Reporter. Type of ... Rapid Labeling of Metabolically Engineered Cell-Surface Glycoconjugates with a Carbamate-Linked Cyclopropene Reporter. In: ... Rapid Labeling of Metabolically Engineered Cell-Surface Glycoconjugates with a Carbamate-Linked Cyclopropene Reporter}, year={ ...
InsecticidesPesticidesEthylMethylInsecticideOrganophosphates and carbamatesPyrethroidsPesticidePhenylCarbarylDerivativesSynthesisCarbamicCarbofuranExposureCompoundsUrethaneVinyl CarbamateEstersPoisoningAminesCarbon dioxideAmineThiocarbamatesAminoPost-translationaIsopropylAChESaltsEfficacy2017DoxorubicinChemical
Insecticides30
- Typically, polyurethane polymers are made by combining diisocyanates, e.g. toluene diisocyanate, and diols, where the carbamate groups are formed by reaction of the alcohols with the isocyanates: RN=C=O + R′OH → RNHC(O)OR′ The so-called carbamate insecticides feature the carbamate ester functional group. (wikipedia.org)
- citation needed] While the carbamate acetylcholinesterase inhibitors are commonly referred to as "carbamate insecticides" due to their generally high selectivity for insect acetylcholinesterase enzymes over the mammalian versions, the most potent compounds such as aldicarb and carbofuran are still capable of inhibiting mammalian acetylcholinesterase enzymes at low enough concentrations that they pose a significant risk of poisoning to humans, especially when used in large amounts for agricultural applications. (wikipedia.org)
- Carbamates are highly toxic insecticides, with current pesticide use registrations. (usda.gov)
- Carbamate insecticides cause nerves/neurons to remain in constant activity and excitation. (lortsmith.com)
- N-methyl carbamate insecticides (carbamates) have been widely used in the U.S. and throughout the world. (cdc.gov)
- In agricultural applications, the use of the carbamate insecticides has decreased, being replaced by pyrethroid and other insecticides. (cdc.gov)
- Carbamate insecticides act by inhibiting acetylcholinesterase enzymes, which leads to an increase of acetylcholine in the nervous system. (cdc.gov)
- however, carbamate insecticides generally are reversible inhibitors of acetylcholinesterase activity, acting for a shorter time than organophosphate pesticides. (cdc.gov)
- Carbamate insecticides are rapidly eliminated from the body. (cdc.gov)
- In the National Biomonitoring Program, two carbamate metabolites that are measured relate to two (carbofuran and propoxur) of about nine carbamate insecticides still used in the U.S. (cdc.gov)
- Agricultural use of carbamate insecticides and risks of non-Hodgkin's lymphomas (NHL) have been linked in some but not all occupational epidemiologic studies. (who.int)
- Moreover, studies on associated risks of NHL by histological subtype of NHL and by type of carbamate insecticides used are scarce. (who.int)
- We evaluated the effects of carbamate insecticides on the risks of NHL and three major histological subtypes of NHL - multiple myeloma (MM), chronic lymphocytic leukaemia / small lymphocytic lymphoma (CLL/SLL), diffuse large B-cell lymphoma (DLBCL) - in a sample of 65,630 French farmers from the prospective cohort AGRICAN. (who.int)
- Their answers were crossed with data from the French crop-exposure matrix, PESTIMAT, to assess their exposure to 19 specific carbamate insecticides by purpose of pesticide use (soil, animals, barns or seeds). (who.int)
- Multivariate Cox proportional hazards models with age as time scale and gender as a covariate were used to estimate hazard ratios (HRs) with 95% confidence intervals (CIs) for NHL risks (by subtype and overall) associated with exposure to carbamate insecticides. (who.int)
- The risk of MM was elevated in participants who had used any carbamate insecticides at least on barns (HR = 1.69, 95% CI: 1.00-2.87). (who.int)
- The risk of MM was also increased for those who used any carbamate insecticides on animals (HR = 1.64, 95% CI: 0.96-2.81) and at least on soil (HR = 1.27, 95% CI: 0.75-2.15) although the 95% CIs included 1.00. (who.int)
- Use of any carbamate insecticides was not associated with CLL/SLL (HR = 0.88, 95% CI: 0.57-1.36), DLBCL (HR = 0.69, 95% CI: 0.39-1.24) or NHL overall (HR = 1.01, 95% CI: 0.80-1.27). (who.int)
- Our results may suggest a potential role of carbamate insecticides use on animals or barns in the etiology of MM. Further analyses on specific carbamate insecticides and respective duration of use are ongoing. (who.int)
- What is the mode of action of organophosphorus insecticides and carbamates? (ru-facts.com)
- Organophosphate and carbamate insecticides are designed to kill different insects and other pests. (ru-facts.com)
- What are carbamates insecticides? (ru-facts.com)
- In the presence of OP insecticides, AChE is phosphorylated, whereas in the presence of carbamate insecticides, the enzyme is carbamylated. (ru-facts.com)
- The objective of this study was to determine diagnostic doses and diagnostic times for laboratory Lutzomyia longipalpis (Lutz & Nieva) and Phlebotomus papatasi (Scopoli) to ten insecticides, including pyrethroids, organophosphates, carbamates, and DDT, that are used worldwide to control vectors. (biomedcentral.com)
- Sand fly populations around the world have been exposed to the four main classes of insecticides: organochlorines, organophosphates, carbamates and pyrethroids. (biomedcentral.com)
- As of this date, I hereby determine that there is a significant potential for a public health emergency that has a significant potential to affect national security or the health and security of United States citizens living abroad and that involves nerve agents or certain insecticides (organophosphorus and/or carbamate). (phe.gov)
- Now, The most commonly used insecticides are the organophosphates, carbamates and pyrethroids. (futurelearn.com)
- Detection of carbamate insecticides by liquid chromatography/mass spectrometry. (tamu.edu)
- In the past, soil-applied organophosphate and carbamate insecticides have provided some suppression of nematodes, minimizing nematode populations to the point that damage went unnoticed when these materials were used for corn rootworm and secondary insect protection. (syngenta-us.com)
- In fact, early on, the development of the carbamate insecticides was generally seen as something of a major breakthrough in pesticide chemistry, since the carbamates did not have the persistence of the chlorinated pesticides - which Rachel Carson would later single out in her seminal pesticide critique of 1962, Silent Spring . (pophistorydig.com)
Pesticides11
- Neurotoxicologic studies of two carbamate pesticides in subacute animal experiments. (ilo.org)
- We propose that within the first three years of funding we will validate the performance of a qualitative screening method for carbamate pesticides in feed, rumen (orstomach) content and liver. (usda.gov)
- In Canada, an assessment of the cumulative health risks for active ingredients belonging to the N-methyl carbamate (NMC) class of pesticides, as described in Science Policy Note SPN2018-02, Cumulative Health Risk Assessment Framework , is underway. (canada.ca)
- As outlined in Re-evaluation Note REV2018-17, Initiation of Cumulative Health Risk Assessment - N-Methyl Carbamates , the NMC class of pesticides consists of five technical grade active ingredients registered in Canada, carbaryl, formetanate hydrochloride, methomyl, oxamyl, and propoxur, as well as consideration of six additional pesticides that could be present on imported food commodities. (canada.ca)
- Carbamates are acetylcholinesterase inhibitors abundant in various pesticides and they are also used in medicine. (symptoma.com)
- Patient history may reveal occupational exposure to pesticides containing carbamates (farming, agriculture etc. (symptoma.com)
- The impact of long term exposure to cholinesterase (ChE)-inhibiting organophosphate (OP) and carbamate (C) pesticides on the respiratory health of agricultural workers in India was investigated. (nih.gov)
- Acaricides are pesticides and includes antibiotic acaricides, carbamate acaricides , and formamidine acaricides, among others. (expertmarketresearch.com)
- Laboratory experimental studies using model compounds suggest that many pesticides currently used in Europe - including organophosphates, carbamates, pyrethroids, ethylenebisdithiocarbamates, and chlorophenoxy herbicides - can cause neurodevelopmental toxicity. (biomedcentral.com)
- There are three main types of pesticides: organochlorine, organophosphate and carbamates. (buchi.com)
- Organophosphates and carbamates are compounds used extensively in pesticides and dewormers. (equimed.com)
Ethyl8
- In contrast, the substance commonly called "urethane", ethyl carbamate, is neither a component of polyurethanes, nor is it used in their manufacture. (wikipedia.org)
- Given the concern that over-fertilized vines, or excessive must nitrogen additions, might enhance the formation of the cancerigenous compound ethyl carbamate , these authors artificially enriched Tempranillo juices and then evaluated whether ethyl carbamate had increased beyond levels considerred safe. (ucdavis.edu)
- Ethyl carbamate (EC, urethan) is carcinogenic probably because it is converted in vivo to vinyl carbamate and then to vinyl carbamate epoxide, which reacts with DNA bases. (elsevier.com)
- Additionally, substances like ethyl carbamate (urethane) may be produced. (wikipedia.org)
- A carbamate ester obtained by formal condensation of the carboxy group of ethyl(methyl)carbamic acid with the phenolic OH group of 3-[(1 S )-1-(dimethylamino)ethyl]phenol. (ebi.ac.uk)
- The goals of this study were to verify the occurrence of furfuryl alcohol (FA) and carbonyl compounds (acetaldehyde, acrolein, ethyl carbamate (EC), formaldehyde and furfural) in sparkling wines and to evaluate, for the first time, whether the consumption of the samples under study could represent risk to consumers health. (scielo.br)
- Furfuryl alcohol (FA) and carbonyl compounds, including acetaldehyde, acrolein, formaldehyde, furfural and ethyl carbamate may form adducts with the DNA due to their electrophilic nature. (scielo.br)
- Polyurethane is composed of urethane (or ethyl carbamate) groups joined by carbamate links. (iqsdirectory.com)
Methyl6
- Laboratory analysis indicated that the product contained the carbamate pesticide aldicarb (2-methyl-2-(methylthio)-propionaldehyde O-(methylcarbamoyl) oxime), which is not registered for use as a rodenticide in the United States. (cdc.gov)
- Carbamates are N-methyl carbamates derived from a carbamic acid and cause carbamylation of acetylcholinesterase at neuronal synapses and neuromuscular junctions. (ru-facts.com)
- Synthesis Methyl N-phenyl carbamate (MPC) as an intermediate precursor of isocyanate is one of the attractive process, which is conducted by reacting aniline and dimethyl carbonate (DMC). (magnusgroup.org)
- In this research, an assessment of the influence of varying concentrations of Methyl-5-benzoyl-2-benzimidazole Carbamate (mebendazole) as an organic corrosion inhibitor for mild steel in 1.0M sulphuric acid solution was investigated. (ijreiblog.com)
- Furadan 3G (Carbofuran) a systematic N-methyl carbamate pesticide was orally administered at doses of 0.15, 0.1, and 0.05mg/kg body weight to normal male and female albino Wistar rat for eleven (11) weeks. (ispub.com)
- 2002). Carbofuran (2, 3-dihydro-2, 2-dimethyl-7-benzofuranylmethylcarbamate), is a systemic N-methyl carbamate pesticide with predominantly contact (dermal-absorption through the intact skin) and stomach action (vomiting, nausea, abdominal cramp, diarrhea) (Kaliwal et al. (ispub.com)
Insecticide5
- Genotoxic effects of the carbamate insecticide methomyl. (elsevier.com)
- The carbamate insecticide methomyl and the methomyl-containing technical formulation 'Lannate 25' were tested on whole blood human lymphocyte cultures. (elsevier.com)
- Dive into the research topics of 'Genotoxic effects of the carbamate insecticide methomyl. (elsevier.com)
- On the basis of this determination, I also hereby declare that circumstances exist justifying the authorization of emergency use of injectable treatments for nerve agent or certain insecticide (organophosphorus and/or carbamate) poisoning pursuant to section 564 of the Federal Food, Drug, and Cosmetic Act, subject to the terms of any authorization issued under that section. (phe.gov)
- Promecarb (Carbamult) - A carbamate insecticide useful for fruits. (fsu.edu)
Organophosphates and carbamates5
- In different ways, organophosphates and carbamates tend to cause the nervous system to stop working properly. (cdc.gov)
- Organophosphates and carbamates, although different structurally, both inhibit cholinesterase activity. (symptoma.com)
- Diagnostic doses were determined only during the exposure bioassay for the organophosphates and carbamates. (biomedcentral.com)
- However, organophosphates and carbamates are toxic to the nervous system. (futurelearn.com)
- For example, organophosphates and carbamates are potent acetylcholinesterase inhibitors which lead to acetylcholine accumulation and neurotoxicity. (futurelearn.com)
Pyrethroids1
- The control agents contained pyrethroids (mostly permethrin, but also deltamethrin and cypermethrin) and carbamates (bendiocarb, propoxur). (eurekamag.com)
Pesticide1
- 531.1 Carbamate Pesticide Calibration Mixture (cat. (restek.com)
Phenyl4
- 3-Pyridylmethyl-(N-substituted-phenyl-N-hydrocarbyl)carbamates. (justia.com)
- The present invention relates to 3-pyridylmethyl N-cyano-(or methylmercapto or nitro)phenyl-N-alkyl-(or allyl or benzyl or 2-thenyl)carbamates. (justia.com)
- Each 3-pyridylmethyl (N-substituted-phenyl-N-hydrocarbyl)carbamate of this invention or its salt derivatives is a very effective single-dose rodenticide and yet is relatively safe for use as a rodenticide in the presence of animal species, other than rodents, which could inadvertently ingest limited quantities of the compound. (justia.com)
- 3-Pyridylmethyl N-[4-cyano-(or methylmercapto-or nitro-)phenyl]-carbamates are known rodenticides, e.g. see Belgium Pat. (justia.com)
Carbaryl2
- Eighty percent of the carbamates were methomyl and carbaryl. (oklahomafarmreport.com)
- Carbaryl is part of the carbamate family of chemicals. (pophistorydig.com)
Derivatives4
- Thus, three quinoline-O-carbamate derivatives of DCQ antici-pated to have better physicochemical properties than DCQ were assessed in vitro. (preprints.org)
- Cellulose carbamate derivatives were successfully prepared from softwood pulp at 150 °C and 3000 psi for 6 hours. (ncsu.edu)
- In 1938, Hill had reported these cellulose derivatives (cellulose carbamate products), but it was not until 1983 that CCs first went into mass production at the Neste company (Finnish Patent: No 61033, 1983). (ncsu.edu)
- Known hypersensitivity to rivastigmine, other carbamate derivatives, or other components of the formulation. (nih.gov)
Synthesis2
- Here, we report the synthesis of a novel N-acyl-mannosamine derivative bearing a methylcyclopropene tag that is attached to the sugar via a carbamate moiety. (uni-konstanz.de)
- Synthesis and evaluation of benzimidazole carbamates bearing indole moieties for antiproliferative and antitubulin activities. (harvard.edu)
Carbamic5
- Organophosphates are organic compounds that contain phosphorus, while carbamates are salts or esters of carbamic acid. (cdc.gov)
- In organic chemistry, a carbamate is a category of organic compounds with the general formula R2NC(O)OR and structure >N−C(=O)−O−, which are formally derived from carbamic acid (NH2COOH). (wikipedia.org)
- While carbamic acids are unstable, many carbamate esters or ionic) are stable and well known. (wikipedia.org)
- Reaction of carboxylic acids gives acyl azides, which rearrange to isocyanates, and these may be hydrolyzed to carbamic acid or solvolysed to carbamates. (organic-chemistry.org)
- We distinguished ammonium carbamate pairs and a mix of ammonium carbamate and carbamic acid during carbon dioxide chemisorption. (stanford.edu)
Carbofuran1
- Carbofuran (Furadan) - All purpose carbamate for insects, ticks, and fleas. (fsu.edu)
Exposure3
- General population exposure to carbamates occurs during contact with residential uses and less commonly, from ingesting contaminated foods. (cdc.gov)
- Clinical manifestation of carbamate poisoning is highly dependent on the dose, type of carbamate, route of exposure, and concomitant diseases [4]. (symptoma.com)
- Treatment of carbamate poisoning in man INTRODUCTION The Environmental Health Criteria (EHC) monographs produced by the International Programme on Chemical Safety include an assessment of the effects on the environment and on human health of exposure to a chemical or combination of chemicals, or physical or biological agents. (inchem.org)
Compounds1
- Carbamate poisoning, as well as poisoning with organophosphorus compounds (OP), have indistinguishable clinical presentation. (symptoma.com)
Urethane1
- the term "urethane links" describe how carbamates polymerize. (wikipedia.org)
Vinyl Carbamate3
- Both indole-3-carbinol and myo-inositol inhibit the development of vinyl carbamate induced pulmonary adenocarcinoma in mice. (greenmedinfo.com)
- We hypothesized that vinyl carbamate arises from EC by oxidation to 2-hydroxy-EC (HEC) and dehydration of the HEC, rather than by direct dehydrogenation of EC. (elsevier.com)
- The weak activity of HEC supports the view that HEC is not a proximal carcinogenic metabolite of EC, i.e. that vinyl carbamate is produced directly from EC. (elsevier.com)
Esters2
- The salt ammonium carbamate is generated by treatment of ammonia with carbon dioxide: 2 NH3 + CO2 → NH4[H2NCO2] Carbamate esters also arise via alcoholysis of carbamoyl chlorides: R2NC(O)Cl + R'OH → R2NCO2R' + HCl Alternatively, carbamates can be formed from chloroformates and amines: R'OC(O)Cl + R2NH → R2NCO2R' + HCl Carbamates may be formed from the Curtius rearrangement, where isocyanates formed are reacted with an alcohol. (wikipedia.org)
- Organophosphate (OP) and carbamate esters can inhibit acetylcholinesterase (AChE) by binding covalently to a serine residue in the enzyme active site, and their inhibitory potency depends largely on affinity for the enzyme and the reactivity of the ester. (ru-facts.com)
Poisoning3
- Poisoning with carbamates produces overstimulation of muscarinic and nicotinic receptors, resulting in specific clinical presentations. (symptoma.com)
- One study confirmed that out of 1100 patients presenting with carbamate poisoning, 93.8% had tried to attempt suicide [2]. (symptoma.com)
- Additionally, excessive sweating , headache , miosis , cramping in the abdominal cavity , changes in the cardiovascular system are all signs of possible carbamate poisoning [4]. (symptoma.com)
Amines2
- CO2 is generally unreactive but combines rapidly with neutral amines at physiological temperatures and pressures to form carbamates. (bl.uk)
- Various solid carbamates were prepared from the reactions of liquid amines with carbon dioxide in an autoclave and these carbamates were used as stable, efficient alternatives for toxic liquid amines. (ewha.ac.kr)
Carbon dioxide2
- The carbamate is formed when an uncharged lysine side chain near the ion reacts with a carbon dioxide molecule from the air (not the substrate carbon dioxide molecule), which then renders it charged, and, therefore, able to bind the Mg2+ ion. (wikipedia.org)
- Although not usually isolated as such, the salt ammonium carbamate is produced on a large scale as an intermediate in the production of the commodity chemical urea from ammonia and carbon dioxide. (wikipedia.org)
Amine4
- Poly(ethylene glycol) (PEG) based bulk hydrogels and cryogels containing activated carbonate groups as amine reactive handles to facilitate drug conjugations through carbamate linkages were fabricated and evaluated as slow releasing drug reservoirs. (researcher-app.com)
- The use of amine-based carbamates with their dual function, acting as amine curing agents and CO2 blowing agents after their decomposition without by-products, are promising for ecofriendly epoxy foams as high-performance materials. (uni-bayreuth.de)
- The viscosity is altered not only by blending neat amine and its derived carbamate at a fixed pre-curing time, but also by changing the pre-curing time at a fixed blend ratio. (uni-bayreuth.de)
- The study proves that the blending of neat amine and carbamate is beneficial for the foaming performance of carbamate systems. (uni-bayreuth.de)
Thiocarbamates2
- Some othertypes of carbamates, thiocarbamates and dithiocarbamates, are used as herbicides and fungicides. (cdc.gov)
- Some carbamates, thiocarbamates and carbazides / this publication represents the views of an IARC Working Group on the Evaluation of the Carcinogenic Risk of Chemicals to Man, which met in Lyon, 9-15 June 1976. (who.int)
Amino2
- The N-terminal amino groups of valine residues in the α- and β-chains of deoxyhemoglobin exist as carbamates. (wikipedia.org)
- The ε-amino groups of the lysine residues in urease and phosphotriesterase also feature carbamate. (wikipedia.org)
Post-translationa1
- The carbamate modification has been observed on proteins including RuBisCO and haemoglobin but remains largely unexplored as a protein post-translational modification. (bl.uk)
Isopropyl1
- An improved heap storage technology with the use of CIPC (isopropyl N-(3-chlorophenyl) carbamate) has been developed for short-term storage of potatoes. (org.in)
AChE1
- Although carbamates are generally known to inhibit AChE and BuChE by a common mechanism involving covalent bond formation at the active site serine (Figure 1), phenothiazine carbamates show reversible inhibition of BuChE while exhibiting the more common pseudoirreversible inhibition of AChE. (ru-facts.com)
Salts1
- as well as salts with the carbamate anion H2NCOO− (e.g. ammonium carbamate). (wikipedia.org)
Efficacy2
20171
- In order to ensure high-quality, efficient analyses, our work complies with the standard SN EN ISO/IEC 17025:2017 and we are accredited accordingly (STS 0119). (admin.ch)
Doxorubicin1
- In vitro studies demonstrated that the anticancer drug doxorubicin conjugated through carbamate linkers to the cryogels was released and proved effective against MDA-MB-231 human breast cancer cells. (researcher-app.com)
Chemical1
- This thesis presents a novel methodology to identify carbamates using a chemical trapping technique that eliminates their labile nature in combination with tryptic digest-MS analysis. (bl.uk)