Derivatives of carbamic acid, H2NC(=O)OH. Included under this heading are N-substituted and O-substituted carbamic acids. In general carbamate esters are referred to as urethanes, and polymers that include repeating units of carbamate are referred to as POLYURETHANES. Note however that polyurethanes are derived from the polymerization of ISOCYANATES and the singular term URETHANE refers to the ethyl ester of carbamic acid.
Antineoplastic agent that is also used as a veterinary anesthetic. It has also been used as an intermediate in organic synthesis. Urethane is suspected to be a carcinogen.
A carbamate insecticide.
Pesticides designed to control insects that are harmful to man. The insects may be directly harmful, as those acting as disease vectors, or indirectly harmful, as destroyers of crops, food products, or textile fabrics.
A carbamate insecticide and parasiticide. It is a potent anticholinesterase agent belonging to the carbamate group of reversible cholinesterase inhibitors. It has a particularly low toxicity from dermal absorption and is used for control of head lice in some countries.
A class of enzymes that transfers phosphate groups and has a carboxyl group as an acceptor. EC 2.7.2.
A cholinesterase inhibitor that is used as a systemic insecticide, an acaricide, and nematocide. (From Merck Index, 11th ed)
Drugs that inhibit cholinesterases. The neurotransmitter ACETYLCHOLINE is rapidly hydrolyzed, and thereby inactivated, by cholinesterases. When cholinesterases are inhibited, the action of endogenously released acetylcholine at cholinergic synapses is potentiated. Cholinesterase inhibitors are widely used clinically for their potentiation of cholinergic inputs to the gastrointestinal tract and urinary bladder, the eye, and skeletal muscles; they are also used for their effects on the heart and the central nervous system.
An enzyme that catalyzes the hydrolysis of ACETYLCHOLINE to CHOLINE and acetate. In the CNS, this enzyme plays a role in the function of peripheral neuromuscular junctions. EC
The development by insects of resistance to insecticides.
Phenyl esters of carbamic acid or of N-substituted carbamic acids. Structures are similar to PHENYLUREA COMPOUNDS with a carbamate in place of the urea.
The simplest of all peptides. It functions as a gamma-glutamyl acceptor.
A carbamate insecticide with anticholinesterase activity.
Chemicals used to destroy pests of any sort. The concept includes fungicides (FUNGICIDES, INDUSTRIAL); INSECTICIDES; RODENTICIDES; etc.
The monoanhydride of carbamic acid with PHOSPHORIC ACID. It is an important intermediate metabolite and is synthesized enzymatically by CARBAMYL-PHOSPHATE SYNTHASE (AMMONIA) and CARBAMOYL-PHOSPHATE SYNTHASE (GLUTAMINE-HYDROLYZING).
A carbamate that is used as an herbicide and as a plant growth regulator.
Carbamate derivative used as an insecticide, acaricide, and nematocide.
A centrally acting muscle relaxant. Its mode of action is unknown. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1203)
Pesticides or their breakdown products remaining in the environment following their normal use or accidental contamination.
The active insecticidal constituent of CHRYSANTHEMUM CINERARIIFOLIUM flowers. Pyrethrin I is the pyretholone ester of chrysanthemummonocarboxylic acid and pyrethrin II is the pyretholone ester of chrysanthemumdicarboxylic acid monomethyl ester.
Carbon-containing phosphoric acid derivatives. Included under this heading are compounds that have CARBON atoms bound to one or more OXYGEN atoms of the P(=O)(O)3 structure. Note that several specific classes of endogenous phosphorus-containing compounds such as NUCLEOTIDES; PHOSPHOLIPIDS; and PHOSPHOPROTEINS are listed elsewhere.
An aspect of cholinesterase (EC
Carboxylesterase is a serine-dependent esterase with wide substrate specificity. The enzyme is involved in the detoxification of XENOBIOTICS and the activation of ester and of amide PRODRUGS.
Flies of the species Musca domestica (family MUSCIDAE), which infest human habitations throughout the world and often act as carriers of pathogenic organisms.
Organic compounds that contain phosphorus as an integral part of the molecule. Included under this heading is broad array of synthetic compounds that are used as PESTICIDES and DRUGS.
Chemicals that kill or inhibit the growth of fungi in agricultural applications, on wood, plastics, or other materials, in swimming pools, etc.
A compound that, on administration, must undergo chemical conversion by metabolic processes before becoming the pharmacologically active drug for which it is a prodrug.
The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.
A species of mosquito in the genus Anopheles and the principle vector of MALARIA in Africa.
An organothiophosphate cholinesterase inhibitor that is used as an insecticide.
A cholinesterase inhibitor that is rapidly absorbed through membranes. It can be applied topically to the conjunctiva. It also can cross the blood-brain barrier and is used when central nervous system effects are desired, as in the treatment of severe anticholinergic toxicity.
A centrally acting muscle relaxant with a short duration of action.
A urea cycle enzyme that catalyzes the formation of orthophosphate and L-citrulline (CITRULLINE) from CARBAMOYL PHOSPHATE and L-ornithine (ORNITHINE). Deficiency of this enzyme may be transmitted as an X-linked trait. EC
A pre-emergence, selective herbicide for the control of wild oats in various crops.
Compounds which restore enzymatic activity by removing an inhibitory group bound to the reactive site of the enzyme.
Salts or ions of the theoretical carbonic acid, containing the radical CO2(3-). Carbonates are readily decomposed by acids. The carbonates of the alkali metals are water-soluble; all others are insoluble. (From Grant & Hackh's Chemical Dictionary, 5th ed)
Enzymes which catalyze the hydrolysis of carboxylic acid esters with the formation of an alcohol and a carboxylic acid anion.
A polychlorinated pesticide that is resistant to destruction by light and oxidation. Its unusual stability has resulted in difficulties in residue removal from water, soil, and foodstuffs. This substance may reasonably be anticipated to be a carcinogen: Fourth Annual Report on Carcinogens (NTP-85-002, 1985). (From Merck Index, 11th ed)
The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
A member of the BENZODIOXOLES that is a constituent of several VOLATILE OILS, notably SASSAFRAS oil. It is a precursor in the synthesis of the insecticide PIPERONYL BUTOXIDE and the drug N-methyl-3,4-methylenedioxyamphetamine (MDMA).
A genus of mosquitoes (CULICIDAE) that are known vectors of MALARIA.
Any member of the class of enzymes that catalyze the cleavage of the substrate and the addition of water to the resulting molecules, e.g., ESTERASES, glycosidases (GLYCOSIDE HYDROLASES), lipases, NUCLEOTIDASES, peptidases (PEPTIDE HYDROLASES), and phosphatases (PHOSPHORIC MONOESTER HYDROLASES). EC 3.
The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.
An organochlorine insecticide whose use has been cancelled or suspended in the United States. It has been used to control locusts, tropical disease vectors, in termite control by direct soil injection, and non-food seed and plant treatment. (From HSDB)
The chemical alteration of an exogenous substance by or in a biological system. The alteration may inactivate the compound or it may result in the production of an active metabolite of an inactive parent compound. The alterations may be divided into METABOLIC DETOXICATION, PHASE I and METABOLIC DETOXICATION, PHASE II.
Inorganic or organic oxy acids of sulfur which contain the RSO2(OH) radical.
An enzyme that catalyzes the hydrolysis of glycerol monoesters of long-chain fatty acids EC
Alkylating anti-neoplastic agent.
Viscous, nauseating oil obtained from the shrub Croton tiglium (Euphorbaceae). It is a vesicant and skin irritant used as pharmacologic standard for skin inflammation and allergy and causes skin cancer. It was formerly used as an emetic and cathartic with frequent mortality.
A technology, in which sets of reactions for solution or solid-phase synthesis, is used to create molecular libraries for analysis of compounds on a large scale.
The application of smoke, vapor, or gas for the purpose of disinfecting or destroying pests or microorganisms.
An enzyme that catalyzes the formation of carbamoyl phosphate from ATP, carbon dioxide, and glutamine. This enzyme is important in the de novo biosynthesis of pyrimidines. EC
Compounds containing carbon-phosphorus bonds in which the phosphorus component is also bonded to one or more sulfur atoms. Many of these compounds function as CHOLINERGIC AGENTS and as INSECTICIDES.
A species of halophilic archaea whose organisms are nonmotile. Habitats include freshwater and marine mud, animal-waste lagoons, and the rumens of ungulates.
Pesticides used to destroy unwanted vegetation, especially various types of weeds, grasses (POACEAE), and woody plants. Some plants develop HERBICIDE RESISTANCE.
A very strong halogenated derivative of acetic acid. It is used in acid catalyzed reactions, especially those where an ester is cleaved in peptide synthesis.
The reduction or regulation of the population of mosquitoes through chemical, biological, or other means.
An enzyme that catalyzes the hydrolysis of CHOLESTEROL ESTERS and some other sterol esters, to liberate cholesterol plus a fatty acid anion.
A colorless and flammable gas at room temperature and pressure. Ethylene oxide is a bactericidal, fungicidal, and sporicidal disinfectant. It is effective against most micro-organisms, including viruses. It is used as a fumigant for foodstuffs and textiles and as an agent for the gaseous sterilization of heat-labile pharmaceutical and surgical materials. (From Reynolds, Martindale The Extra Pharmacopoeia, 30th ed, p794)
The rate dynamics in chemical or physical systems.

Involvement of two plasmids in the degradation of carbaryl by Arthrobacter sp. strain RC100. (1/1210)

A bacterium capable of utilizing carbaryl (1-naphthyl N-methylcarbamate) as the sole carbon source was isolated from carbaryl-treated soil. This bacterium was characterized taxonomically as Arthrobacter and was designated strain RC100. RC100 hydrolyzes the N-methylcarbamate linkage to 1-naphthol, which was further metabolized via salicylate and gentisate. Strain RC100 harbored three plasmids (designated pRC1, pRC2, and pRC3). Mutants unable to degrade carbaryl arose at a high frequency after treating the culture with mitomycin C. All carbaryl-hydrolysis-deficient mutants (Cah-) lacked pRC1, and all 1-naphthol-utilization-deficient mutants (Nat-) lacked pRC2. The plasmid-free strain RC107 grew on gentisate as a carbon source. These two plasmids could be transferred to Cah- mutants or Nat- mutants by conjugation, resulting in the restoration of the Cah and Nah phenotypes.  (+info)

Efficacy and safety of rivastigmine in patients with Alzheimer's disease: international randomised controlled trial. (2/1210)

OBJECTIVES: To assess the effects of rivastigmine on the core domains of Alzheimer's disease. DESIGN: Prospective, randomised, multicentre, double blind, placebo controlled, parallel group trial. Patients received either placebo, 1-4 mg/day (lower dose) rivastigmine, or 6-12 mg/day (higher dose) rivastigmine. Doses were increased in one of two fixed dose ranges (1-4 mg/day or 6-12 mg/day) over the first 12 weeks with a subsequent assessment period of 14 weeks. SETTING: 45 centres in Europe and North America. PARTICIPANTS: 725 patients with mild to moderately severe probable Alzheimer's disease diagnosed according to the Diagnostic and Statistical Manual of Mental Disorders, fourth edition, and the criteria of the National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer's Disease and Related Disorders Association. OUTCOME MEASURES: Cognitive subscale of the Alzheimer's disease assessment scale, rating on the clinician interview based impression of change incorporating caregiver information scale, and the progressive deterioration scale. RESULTS: At the end of the study cognitive function had deteriorated among those in the placebo group. Scores on the Alzheimer's disease assessment scale improved in patients in the higher dose group when compared with patients taking placebo (P<0.05). Significantly more patients in the higher dose group had improved by 4 points or more than had improved in the placebo group (24% (57/242) v 16% (39/238)). Global function as rated by the clinician interview scale had significantly improved among those in the higher dose group compared with those taking placebo (P<0.001), and significantly more patients in the higher dose group showed improvement than did in the placebo group (37% (80/219) v 20% (46/230)). Mean scores on the progressive deterioration scale improved from baseline in patients in the higher dose group but fell in the placebo group. Adverse events were predominantly gastrointestinal, of mild to moderate severity, transient, and occurred mainly during escalation of the dose. 23% (55/242) of those in the higher dose group, 7% (18/242) of those in the lower dose group, and 7% (16/239) of those in the placebo group discontinued treatment because of adverse events. CONCLUSIONS: Rivastigmine is well tolerated and effective. It improves cognition, participation in activities of daily living, and global evaluation ratings in patients with mild to moderately severe Alzheimer's disease. This is the first treatment to show compelling evidence of efficacy in a predominantly European population.  (+info)

Treatment with amprenavir alone or amprenavir with zidovudine and lamivudine in adults with human immunodeficiency virus infection. AIDS Clinical Trials Group 347 Study Team. (3/1210)

Amprenavir is a human immunodeficiency virus (HIV) protease inhibitor with a favorable pharmacokinetic profile and good in vitro activity. Ninety-two lamivudine- and protease inhibitor-naive individuals with >/=50 CD4 cells/mm3 and >/=5000 HIV RNA copies/mL were assigned amprenavir (1200 mg) alone or with zidovudine (300 mg) plus lamivudine (150 mg), all given every 12 h. After a median follow-up of 88 days, the findings of a planned interim review resulted in termination of the amprenavir monotherapy arm. Among 85 subjects with confirmed plasma HIV RNA determination, 15 of 42 monotherapy versus 1 of 43 triple-therapy subjects had an HIV RNA increase above baseline or 1 log10 above nadir (P=.0001). For subjects taking triple therapy at 24 weeks, the median decrease in HIV RNA was 2.04 log10 copies/mL, and 17 (63%) of 27 evaluable subjects had <500 HIV RNA copies/mL. Treatment with amprenavir, zidovudine, and lamivudine together reduced the levels of HIV RNA significantly more than did amprenavir monotherapy.  (+info)

A 1-year multicenter randomized double-blind comparison of repaglinide and glyburide for the treatment of type 2 diabetes. Dutch and German Repaglinide Study Group. (4/1210)

OBJECTIVE: Repaglinide is a newly developed oral blood glucose-lowering agent that exerts its effect by stimulating insulin secretion. This multicenter study was designed to compare the efficacy and safety of this drug with glyburide in a 1-year randomized double-blind study of outpatients with type 2 diabetes. RESEARCH DESIGN AND METHODS: A total of 424 subjects (154 women, 270 men) participated and had the following characteristics: age, 61 +/- 9 years; duration of diabetes. 8 years (range 0.5-35); BMI, 28.3 +/- 3.5 kg/m2; HbA1c, 7.1 +/- 1.4%; and fasting plasma glucose, 10.8 +/- 3.1 mmol/l. The majority of the subjects (91%) were previously treated with sulfonylurea, alone or in combination with metformin. The patients were randomized to a 2:1 ratio of repaglinide (0.5-4 mg t.i.d.) or glyburide (1.75-10.5 mg daily) treatment. The study protocol included a screening visit to assess patient eligibility; a titration period of 6-8 weeks, during which the dosages of repaglinide and glyburide were optimized; and a subsequent 12-month treatment period on fixed, optimal dosages. RESULTS: The trial was completed by 320 subjects, 211 (74%) in the repaglinide and 109 (78%) in the glyburide group. HbA1c initially decreased in both groups and then increased during the second half-year of the maintenance period to a similar extent in the repaglinide and glyburide subjects (0.58 and 0.45% vs. at screening, respectively). In the small group of subjects who previously controlled their condition with diet only (n = 37), a sustained improvement of metabolic control could be observed with both drugs, which was slightly better with glyburide than with repaglinide (theta HbA1c -2.4 vs. -1.0%; P < 0.05). The same trends were seen with fasting plasma glucose. There were no changes in serum lipids. Over the course of the study, 15% of the repaglinide-treated and 13% of glyburide-treated subjects withdrew due to adverse events, mostly hyperglycemia. No differences in adverse events between both drugs were reported. There were no differences in incidences of hypoglycemia. CONCLUSIONS: Repaglinide is a safe and efficacious oral blood glucose-lowering agent, with a potency similar to that of glyburide. Its rapid onset of action and hepatic clearance allows meal-related administration, including in subjects with impaired kidney function.  (+info)

Structural and mechanistic aspects of transcriptional induction of cytochrome P450 1A1 by benzimidazole derivatives in rat hepatoma H4IIE cells. (5/1210)

The effect of several structurally different benzimidazole compounds on CYP1A1 expression at the transcriptional, mRNA and protein levels was investigated in the rat hepatoma H4IIE cell line. Omeprazole, thiabendazole, carbendazim, 2-mercaptobenzimidazole and 2-mercapto-5-methoxybenzimidazole caused a dose-dependent increase in CYP1A1 protein levels that reached maximum effect at 250 microm, as measured by Western blot. In addition, hydroxyomeprazole, 2-aminobenzimidazole and 2-mercapto-5-nitro-benzimidazole caused a notable increase in CYP1A1 protein expression, whereas 5-O-desmethylomeprazole, 2-hydroxybenzimidazole, 2-benzimidazole propionic acid and 5-benzimidazole carboxylic acid were ineffective. Thus, benzimidazole substituted with a thiol or an amino group in the 2-position were active inducers. Northern blot analysis confirmed an extensive increase of CYP1A1 mRNA induced by omeprazole and 2-mercapto-5-methoxybenzimidazole which was 32% and 49% of maximal induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) respectively, whereas thiabendazole and carbendazim showed approximately 15% increase as compared to TCDD. Transient transfection of H4IIE cells, with a XRE-pGL3 reporter gene construct revealed a 2.3-4.3-fold induction by carbendazim, thiabendazole, and 2-mercapto-5-methoxybenzimidazole as compared to a 3.3- and 23-fold induction by omeprazole and TCDD, respectively. Thus, these data indicate that the benzimidazoles utilize the aryl hydrocarbon receptor-arnt-XRE-mediated signal-transduction pathway for induction of the CYP1A1 gene.  (+info)

A common pharmacophore for cytotoxic natural products that stabilize microtubules. (6/1210)

Taxol (paclitaxel), a complex diterpene obtained from the Pacific yew, Taxus brevifolia, is arguably the most important new drug in cancer chemotherapy. The mechanism of cytotoxic action for paclitaxel-i.e., the stabilization of microtubules leading to mitotic arrest-is now shared by four recently identified natural products, eleutherobin, epothilones A and B, and discodermolide. Their ability to competitively inhibit [3H]paclitaxel binding to microtubules strongly suggests the existence of a common binding site. Recently, we have developed nonaromatic analogues of paclitaxel that maintain high cytotoxicity and tubulin binding (e.g., nonataxel). We now propose a common pharmacophore that unites paclitaxel, nonataxel, the epothilones, eleutherobin, and discodermolide, and rationalizes the extensive structure-activity relationship data pertinent to these compounds. Insights from the common pharmacophore have enabled the development of a hybrid construct with demonstrated cytotoxic and tubulin-binding activity.  (+info)

Pharmacological activities of TEI-8362, a novel inhibitor of human neutrophil elastase. (7/1210)

1. TEI-8362, 4-(N-(3-((3-carboxypropyl)amino)-8-methyl-1-oxo-4-azaisochromen-6- yl)carbamoyl)-4-((phenylmethoxy)carbonylamino)butanoic acid (C26H28N4O9) is a novel inhibitor of human neutrophil elastase (HNE). We evaluated its pharmacological profile in vitro and in vivo. 2. TEI-8362 demonstrated potent inhibition of HNE with a Ki value of 1.38 x 10(-9) M. Its selectivity for HNE among a variety of proteases ranged from 163 fold to 68,000 fold in favour of HNE. 3. The pulmonary haemorrhage that occurred after i.t. instillation of HNE to hamsters was inhibited by either i.t., i.v., or inhalant administration of TEI-8362. 4. Intratracheal administration of lipopolysaccharide induced pulmonary neutrophilia. Twenty-four hours after lipopolysaccharide administration, the additional treatment with formyl-methionyl-leucyl-phenylalanine resulted in a specific neutrophil-dependent acute lung injury. In this model, lung injury was significantly attenuated by i.t., i.v., or inhalant administration of TEI-8362. 5. These pharmacological actions of TEI-8362 suggest that this drug has therapeutic value in the treatment of destructive lung diseases due to neutrophils.  (+info)

Does an association between pesticide use and subsequent declines in catch of Atlantic salmon (Salmo salar) represent a case of endocrine disruption? (8/1210)

Historical aerial applications of the insecticide Matacil 1.8D provide an opportunity to look for potential effects of the endocrine disrupting compound 4-nonylphenol (4-NP) on Atlantic salmon (Salmo salar) populations. Matacil 1.8D contained the carbamate insecticide aminocarb, with 4-NP as primary solvent. Between 1975 and 1985 Matacil 1.8D was applied to forests in Atlantic Canada to control damage from the spruce budworm (Choristoneura fumiferana). After spraying, estimated concentrations of 4-NP in water fell within a range in which estrogenic effects might be anticipated. The spraying coincided with final stages of smolt development in salmon. Salmon catch data were evaluated considering effects on survival of the smolt stage. There was a significant negative relationship between the returns of salmon and the proportion of tributaries sprayed within the Restigouche River drainage basin in 1977. There was also a broader event of unusually heavy salmon smolt mortality in 1977, which contains a significant relationship indicating that where Matacil 1.8D spraying occurred, the smolt mortality increased. For 16 rivers exposed to spraying between 1973 and 1990, a significant proportion (p<0.005) of the lowest salmon catches coincided with Matacil 1.8D spraying. A decline coinciding with the use of Matacil 1.8D was also apparent in blueback herring (Alosa aestivalis) catches in New Brunswick. Because similar relationships were not evident for Matacil 1.8F or fenitrothion, neither of which were formulated with 4-NP, we hypothesize that the 4-NP in Matacil 1.8D was the causal agent. Concentrations of 4-NP described here are within current ranges encountered in industrial effluents and municipal sewage outfalls.  (+info)

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Carbosulfan (2,3-dihydro-2,2dimethyl-7-benzofuronyl [(dibutyl amino) thio] methyl] a carbamate insecticide and acaricide was administered orally at an effective dose of 48 mg/kg/day to albino mice for 5, 10, 20 and 30 days .Control mice received similar quantities of olive oil. Daily body weights were recorded and mice were sacrificed after 24 hours after the terminal exposure. The histologic examination of liver of the mice treated with carbosulfan for 10, 20 and 30 days revealed the dilation of central vein and sinusoids between hypertrophied hepatocytes. Vacuolization and hyalinization of hepatocytes with loss of radial arrangement. Treatment with carbosulfan for 20 days in female and male mice resulted in a significant decrease in protein and liver glycogen contents in female mice, whereas in male mice the glycogen was not changed significantly in the liver. The cholesterol content was increased significantly in male mice, but in female mice there was no significant change. Treatment with
Derivatives of carbamic acid, H2NC(=O)OH. Included under this heading are N-substituted and O-substituted carbamic acids. In general carbamate esters are referred to as urethanes, and polymers that include repeating units of carbamate are referred to as POLYURETHANES. Note however that polyurethanes are derived from the polymerization of ISOCYANATES and the singular term URETHANE refers to the ethyl ester of carbamic acid.. ...
Carbamic acid, [chloro(chloroethoxyphosphinyl)methyl]-, ethyl ester | C6H11Cl2NO4P+ | CID 71382874 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
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(S)-(1-azabicyclo(2.2.2)oct-3-yl)carbamic acid (S)-1-(2-fluorophenyl) ethyl ester: a nicotinic receptor alpha7 selective agonist; structure in first source
Syntheses of N- and C-protected derivatives of 1-(1-aminoethyl)ferrocene-1-carboxylic acid (Fcca) and isomeric carbamic acid are reported. The first attempt to prepare N-Ac-Fcca (8) by cleavage of...
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This page contains information on the chemical Carbamic acid, (oxybis(1H-benzimidazole-5,2-diyl))bis-, dimethyl ester including: 2 synonyms/identifiers.
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Fegley, D., Gaetani, S., Duranti, A., Tontini, A., Mor, M. and Tarzia, G. (2005) Characterization of the fatty acid amide hydrolase inhibitor cyclohexyl carbamic acid 3- carbamoyl-biphenyl-3-yl ester (URB597), effects on anandamide and oleoylethanolamide deactivation. Journal of Pharmacology & Experimental Therapeutics, 313, 352-358. doi10.1124/jpet.104.078980
Surface water sampling in 2007-2010 measured the incident of carbamates and metalaxyl during bottom flow circumstances and wet weather conditions occasions in southern Ontario surface area waters. may possess resulted from KC-404 squirt drift mainly. on an array of vegetation was?contained in the analytical method. While specialized enrollment of both carbofuran and pirimicarb in Canada provides expired both items had been used during a number of the monitoring period (2007-2010) and by the finish of 2013 had been still in the residue explanations list beneath the Canadian Infestations Control Products Action and supervised by Provincial and Government agencies (Wellness Canada 2013). Environment Canada undertook surface area drinking water sampling for carbamates and metalaxyl over the time 2007-2010 in Ontario Canada. The goal of this research was to gauge the incident and distribution of carbamate pesticides and metalaxyl in southern Ontario surface area waters within a thorough pesticide ...
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The global agricultural sector pervasively uses organophosphates and carbamates for production of pesticides, germicides and other chemicals that eradicate pests from crop yield. Apart from some having therapeutic functions, most of organophosphates and carbamates are highly poisonous for consumption and can even result into fatality.
This study allows patients who have successfully participated in ACTG 347 or other trials involving amprenavir to continue treatment with amprenavir, ZDV, d4T, and 3TC. Additionally, this study provides patients whose HIV-1 RNA was not reduced to undetectable levels or who had a significant increase in plasma levels (treatment failures) the opportunity to change to a potentially more active regimen that includes indinavir, nevirapine, lamivudine, and stavudine.. Patients with HIV RNA less than 500 copies/ml on a regimen containing amprenavir are treated on Arm A; those with greater than or equal to 500 copies while on or intolerant to a regimen containing amprenavir are treated on Arm B.. Arm A: Amprenavir + ZDV + d4T + 3TC. Arm B: IND + NVP + 3TC + d4T. Patients enrolled in Arm A who fail therapy may roll over to Arm B. Patients in Arm B who fail therapy discontinue study medications and seek best available treatment.. [AS PER AMENDMENT 2/27/98: Patients with HIV RNA less than 500 copies/ml ...
This study allows patients who have successfully participated in ACTG 347 or other trials involving amprenavir to continue treatment with amprenavir, ZDV, d4T, and 3TC. Additionally, this study provides patients whose HIV-1 RNA was not reduced to undetectable levels or who had a significant increase in plasma levels (treatment failures) the opportunity to change to a potentially more active regimen that includes indinavir, nevirapine, lamivudine, and stavudine.. Patients with HIV RNA less than 500 copies/ml on a regimen containing amprenavir are treated on Arm A; those with greater than or equal to 500 copies while on or intolerant to a regimen containing amprenavir are treated on Arm B.. Arm A: Amprenavir + ZDV + d4T + 3TC. Arm B: IND + NVP + 3TC + d4T. Patients enrolled in Arm A who fail therapy may roll over to Arm B. Patients in Arm B who fail therapy discontinue study medications and seek best available treatment.. [AS PER AMENDMENT 2/27/98: Patients with HIV RNA less than 500 copies/ml ...
A curable coating composition is described comprising a carbamate functional material and a crosslinking agent, reactive with the carbamate group. The composition further comprises a third component that is a mixture of catalysts including a phosphorus containing acid or acid derivative and other acid catalysts. Coatings prepared with this coating composition can be cured and coated with additional coating(s), providing good intercoat adhesion to the subsequent coating.
Emergence of resistance to protease inhibitor amprenavir in human immunodeficiency virus type 1-infected patients: Selection of four alternative viral protease genotypes and influence of viral susceptibility to coadministered reverse transcriptase nucleoside inhibitors ...
The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. However, NIST makes no warranties to that effect, and NIST shall not be liable for any damage that may result from errors or omissions in the Database ...
The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. However, NIST makes no warranties to that effect, and NIST shall not be liable for any damage that may result from errors or omissions in the Database ...
dosed preprandially with three meals. Absorption After oral administration, repaglinide is completely absorbed from the gastrointestinal tract. After single and multiple oral doses in healthy subjects or in patients, peak plasma drug levels (Cmax) occur within 1 hour (Tmax). Repaglinide is eliminated from the blood stream with a half-life of approximately 1 hour. The mean absolute bioavailability is 56%. When repaglinide was given with food, the mean Tmax was not changed, but the mean Cmax and AUC (area under the time/plasma concentration curve) were decreased 20% and 12.4%, respectively.. Distribution After intravenous (IV) dosing in healthy subjects, the volume of distribution at steady state (Vss) was 31 L, and the total body clearance (CL) was 38 L/h. Protein binding and binding to human serum albumin was greater than 98%.. Metabolism and Elimination. Repaglinide is completely metabolized by oxidative biotransformation and direct conjugation with glucuronic acid after either an IV or oral ...
U.S. EPA Method 531.2 describes the determination of widely used carbamate pesticides in raw surface water using HPLC with fluorescence detection following postcolumn derivatization, which enhances method sensitivity and selectivity as compared to UV absorbance detection.
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The National Agricultural Library is one of four national libraries of the United States, with locations in Beltsville, Maryland and Washington, D.C. It houses one of the worlds largest and most accessible agricultural information collections and serves as the nexus for a national network of state land-grant and U.S. Department of Agriculture field libraries. In fiscal year 2011 (Oct 2010 through Sept 2011) NAL delivered more than 100 million direct customer service transactions. ...
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Fatty acid amide hydrolase (FAAH) is responsible for hydrolysis of endocannabinoid, anandamide (AEA), and N-acyl ethanolamines such as palmitoylethanolamine (PEA) and N-oleoylethanolamide (OEA). Genetic deletion or pharmacological inactivation of FAAH shows site-specific elevation of AEA that plays a role in the modulation of pain and other neurodegenerative disorders. The review elaborates recent progress and current status of diverse structural classes of reversible and irreversible FAAH inhibitors. The discussion also addresses ligand-enzyme active site interactions and mechanism of enzyme inactivation, emerging approaches to novel FAAH inhibitors, and ongoing efforts to address gaps in therapeutic utility of FAAH inhibitors.
As a member of the transient receptor potential (TRP) ion channel superfamily, the ligand-gated ion channel TRPA1 has been implicated in nociceptive function and pain states. The endogenous ligands that activate TRPA1 remain unknown. However, various agonists have been identified, including environmental irritants (e.g., acrolein) and ingredients of pungent natural products [e.g., allyl isothiocyanate (ITC), cinnamaldehyde, allicin, and gingerol]. In general, these agents are either highly reactive, nonselective, or not potent or efficacious, significantly limiting their utilities in the study of TRPA1 channel properties and biological functions. In a search for novel TRPA1 agonists, we identified 3 -carbamoylbiphenyl-3-yl cyclohexylcarbamate (URB597), a potent and systemically active inhibitor of fatty acid amide hydrolase (FAAH). This enzyme is responsible for anandamide degradation and therefore has been pursued as an antinociceptive and antiepileptic drug target. Using Ca influx assays and patch
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chemBlink provides information about CAS # 83269-15-2, (5-Amino-3-phenylpyrido[3,4-b]pyrazin-7-yl)carbamic acid ethyl ester, NSC 337238, molecular formula: C16H15N5O2.
HPLC Application #18282: Carbamate Pesticides on Kinetex 2.6µm C18 50 x 4.6mm ID. Column used: Kinetex® 2.6 µm C18 100 Å, LC Column 50 x 4.6 mm, Ea Part#: 00B-4462-E0
0015]Due to the relative stability amides in vivo, N-acylation of amines to give amide prodrugs has only been used to a limited extent (H. Bundgaard H & M. Johansen, J Pharm Sci., 69 (1980) 44-6). For the same reason, the utility of carbamates as prodrug derivatives for amines is also limited. Introducing an enzymatically hydrolyzable ester function into the carbamate structure may evade such problem. N-(acyloxyalkoxycarbonyl) derivatives of primary or secondary amines are likely to be transformed to the parent amine in vivo (J. Alexander, R. Cargill, S. R. Mohelson and H. Schwamm, J. Med. Chem., 31 (1988) 316-22; U. S. Gates & A. J. Repta, Int. J. Pharm., 40 (1987) 249-55). Enzymatic based hydrolysis of such ester moiety in those derivatives will lead to a (hydroxy-alkoxy)carbonyl derivative which spontaneously decomposes into parent amine via an unstable carbamic acid. Acyloxy-alkyl carbamates as shown in Table 5 and Example 11 are promising biolabile prodrugs for amino functional drugs, since ...
This study is comparing gabapentin enacarbil (600 mg/d) in treatment-naïve restless legs syndrome patients versus a similar group of patients previously treated
Amprenavir (VX-478) is a HIV protease inhibitor (Ki=0.6 nM) used to treat HIV infection. Amprenavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 1.09 μM. - Mechanism of Action & Protocol.
The pharmacokinetic profile for minocycline was determined at the beginning and marriages end of the ethyl carbamate coadministration phase. Patients receiving intracavernous irrigation with minocycline were more likely to achieve successful detumescence than those treated with oral or with subcutaneous thiope
MolCore offers CAS No.140447-78-5, tert-Butyl (2-(piperazin-1-yl)ethyl)carbamate for your research needs.Find product specific information including MFCD02683050,140447-78-5 MSDS,Price,Custom Synthesis.
Applications were made from growth stages R1 (flowering) to R3 (podset) (2), with more than 60% of the trials receiving a pyraclostrobin application at growth stage R3. Locations of fungicide strips were recorded with on-board GPS systems in all 14 trials that received aerial fungicide applications and in approximately 90% of the trials that received ground fungicide applications. In the remaining 10% of the trials, farmers flagged the strips during fungicide applications and recorded GPS coordinates of each strip later during the growing season. Treatments were alternated within each trial to help farmers accommodate treatment applications, allow researchers to verify treatment locations and conduct analysis of yield responses observed at both field and within-field (spatial observations) levels. All discussions in this article are focused only on field-level mean yield responses. More information about the purpose, methodology, and statistical analysis of observations collected in similar ...
Neuroblastoma - Anandamide and 2-arachidonoylglycerol are neuromodulatory lipids interacting with cannabinoid receptors, whose availability is regulated by the balance ...
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The purpose of the present study was to determine the effect of a single oral dose of carbendazim (CARB) on the frequencies of numerical chromosome aberrations in sperm and on micronuclei in peripheral blood erythrocytes of rats. Dual colour FISH on
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You are viewing an interactive 3D depiction of the molecule isopropyl [(2s)-7-cyano-4-(2-pyridinylmethyl)-1,2,3,4-tetrahydrocyclopenta[b]indol-2-yl]carbamate (C22H22N4O2) from the PQR.
In 2018, Top exporters of Cyclic amides (including cyclic carbamates) and their derivatives; n.e.s. in item no. 2924.2 to Czech Republic were Germany ($2,572.71K , 124,242 Kg), China ($2,529.90K , 175,840 Kg), Switzerland ($1,630.25K , 56,350 Kg), India ($293.41K , 8,827 Kg), Belgium ($277.17K , 25,845 Kg ...
The present invention relates to a use of a carbamate compound of formula 1, or a pharmaceutically acceptable salt, solvate or hydrate thereof in the prevention or treatment of diseases associated with an increase in late sodium current.
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Generic Name: Fosamprenavir calcium. Brand Name: Telzir. Manufacturer: GlaxoSmithKline Inc.. Indications: HIV infection. Submission Type: New. Project Status: Complete. Date Recommendation Issued: June 16, 2005. Recommendation Type: List in a similar manner to other drugs in class. ...
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In case of emergency-There may be a time when you need emergency help for a problem caused by your diabetes. You need to be prepared for these emergencies. It is a good idea to wear a medical identification (ID) bracelet or neck chain at all times. Also, carry an ID card in your wallet or purse that says that you have diabetes and a list of all of your medicines.. Too much repaglinide can cause low blood sugar (hypoglycemia). Low blood sugar also can occur if you use repaglinide with another antidiabetic medicine, delay or miss a meal or snack, exercise more than usual, drink alcohol, or cannot eat because of nausea or vomiting. Symptoms of low blood sugar must be treated before they lead to unconsciousness (passing out). Different people may feel different symptoms of low blood sugar. It is important that you learn which symptoms of low blood sugar you usually have so that you can treat it quickly.. Symptoms of low blood sugar include anxiety; behavior change similar to being drunk; blurred ...
Section 1 of this thesis contains an introduction to method development in organic synthesis, multicomponent reactions, sulfonyl azides, tracer development in 11C chemistry and the biological target.. Section 2 describes the use of sulfonyl azides in carbonylative chemistry. Paper I covers development of a diazotransfer protocol. In total, 30 arylsulfonyl azides were synthesised from primary sulfonamides (20-90% yield). 15N mechanistic studies were carried out and in Paper II, the products were converted into sulfonamides, sulfonylureas and sulfonyl carbamates (19-90% yield). For ureas and carbamates, a two-chamber protocol was employed to release CO from Mo(CO)6. 15N mechanistic studies showed that the sulfonamides were formed by direct displacement of azide.. Section 3 covers imaging and biological studies of the angiotensin II receptor subtype 2 (AT2R). In Paper III, 12 11C-sulfonyl carbamates were prepared in isolated radiochemical yields of 3-51% via Rh(I)-mediated carbonylation. The first ...
Hydrolysis o f the original sample to the corresponding carbamate, G T X 3 (5), w o u l d increase the toxicity o f the sample 6-fold, to 1400 mouse units. Subsequent epimerization o f the hydrolysate, 5, to a 4:1 mixture o f the carbamates GTX2 (3) and 5 (or hydrolysis o f the epimeric sulfamates 4 and 6 to the same mixture o f carbamates) w o u l d then change the toxicity to 1,120 mouse units. T h e observed toxicity and composition o f the hypothetical sample w h i c h started as pure 6 may l i e anywhere w i t h i n the indicated bounds as these interconversions occur. It can be increased at any point by hydrolysis, toward the toxicity shown o n the upper line. T h e highest toxicity w i l l be attained i f the hydrolysis is performed o n 6 prior to epimerization, resulting i n 5. Hydrolysis o f the epimeric 4 and 6, o r epimerization o f the hydrolysate, will ultimately result i n a stable, equilibrated mixture o f the epimers 3 and 5, with a slightly lower toxicity. T h e hypothetical ...
The carbamic acid is channeled another 35Å to the site where it is phosphorylated 1.3 Substrate Channeling. Proline synthesis was greatly decreased when peptides or amino acids were added to the medium, while glutamate and aspartate were enriched to a greater extent than other amino acids under all conditions. to produce new purine nucleotides. This irreversible reaction is the committed step in fatty acid synthesis. Methionine, on the other hand, is needed in the diet because while it can be â ¦ de novo synthesis of pyrimidine bases de novo synthesis of purines bases Synthesis of deoxyribonucleotides Regulation of nucleotide synthesis Introductions. In this De novo synthesis of purines, each atom in the purine nucleotide came from different sources as mentioned above structure and data. Immediate precursor: Acetyl CoA. This pathway is responsible for the deamination of most amino acids. Higher peptide/amino acid concentrations decreased de novo synthesis. Inhibition of ornithine ...
Preparation of a 1,2,4-triazol-3-one compound substituted in positions 4 and 5 by an alkyl or aryl group and, optionally, in position 2 by an alkyl group, by reacting an ester a of carbamic acid N-substituted by an alkyl or aryl group with a hydrazide of an aliphatic or aromatic carboxylic acid, optionally N-substituted by an alkyl group, in the presence of a strong base.
Repaglinide is presently recommended by the U.S. Food and Drug Administration as a clinical CYP2C8 probe, yet current in vitro and clinical data are inconsistent concerning the role of this enzyme in repaglinide elimination. The aim of the current study was to perform a comprehensive investigation of repaglinide metabolic pathways and assess their contribution to the overall clearance. Formation of four repaglinide metabolites was characterized using in vitro systems with differential complexity. Full kinetic profiles for the formation of M1, M2, M4, and repaglinide glucuronide were obtained in pooled cryopreserved human hepatocytes, human liver microsomes, human S9 fractions, and recombinant cytochrome P450 enzymes. Distinct differences in clearance ratios were observed between CYP3A4 and CYP2C8 for M1 and M4 formation, resulting in a 60-fold M1/M4 ratio in recombinant (r) CYP3A4, in contrast to 0.05 in rCYP2C8. Unbound Km values were within 2-fold for each metabolite across all in vitro ...
|p|Amprenavir (agenerase), an |em|N,N|/em|-disubstituted hydroxyethylamino sulfonamide, is a novel inhibitor of human immunodeficiency virus type 1 (HIV-1) protease that potently inhibits the activity of HIV-1 protease with a value of 50% inhibition conce
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Easy-to-read patient leaflet for Repaglinide and Metformin. Includes indications, proper use, special instructions, precautions, and possible side effects.
Repaglinide and metformin is a prescription drug used to lower blood sugar in people with type 2 diabetes. This eMedTV Web page explains how the medication works, outlines potential side effects, and offers tips on when and how to take it.
Generic Prandin is used for managing type 2 (non-insulin-dependent) diabetes. It is used in addition to diet and exercise to lower blood sugar in adults who cannot manage with diet, exercise, or diabetic medications alone. It may be used with other diabetes medicines.. Generic Prandin (Repaglinide 0.5/1/2mg) C$ 1.01 pill - Diabetes @ All America Trusts | All America Trusts -
Repaglinide can cause low blood sugar (hypoglycemia) especially if you are taking other medicines for diabetes. Consuming large quantities of alcohol, not getting enough calories from food, or doing unusually heavy exercise may also lead to low blood sugar. Symptoms may include chills, cold sweat, dizziness, drowsiness, shaking, fast heartbeat, weakness, headache, fainting, tingling of the hands or feet, or hunger. It is a good habit to carry glucose tablets or gel to treat low blood sugar. If you dont have these reliable forms of glucose, raise your blood sugar quickly by eating a quick source of sugar such as table sugar, honey, candy, or drinking a glass of fruit juice or non-diet soda. Check with your doctor or pharmacist to find out what you should do if you miss a meal ...
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Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Use a specially marked spoon or container to measure each dose. Ask your pharmacist if you do not have one. Household spoons are not accurate. You can take this medicine with or without food, but do not take it with a high fat meal. Take your medicine at regular intervals. Do not take your medicine more often than directed. For your anti-HIV therapy to work as well as possible, take each dose exactly as prescribed. Do not skip doses or stop your medicine even if you feel better. Skipping doses may make the HIV virus resistant to this medicine and other medicines. Do not stop taking except on your doctors advice.. Talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for children as young as 4 years for selected conditions, precautions do apply.. ...
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The salt ammonium carbamate is generated by treatment of ammonia with carbon dioxide: 2 NH3 + CO2 → NH4[H2NCO2] Carbamates also ... Analogues of carbamates with only one of the oxygens replaced by sulfur are called thiocarbamates (2 and 3). Carbamates with ... The "urethane" in the name "polyurethane" refers to these carbamate groups; the term "urethane links" describe how carbamates ... The insect repellent icaridin is a substituted carbamate.[citation needed] While the carbamate acetylcholinesterase inhibitors ...
Carbamate poisoning is poisoning due to exposure to carbamates. Carbamates are typically used as pesticides; however, some also ... King, Andrew M.; Aaron, Cynthia K. (February 2015). "Organophosphate and Carbamate Poisoning". Emergency Medicine Clinics of ...
Organophosphates and carbamates. Organophosphates are organic compounds that contain phosphorus, while carbamates are salts or ... In different ways, organophosphates and carbamates tend to cause the nervous system to stop working properly. Some are used in ...
Investigations Into Ethyl Carbamate, N-Propyl Carbamate, And Urea In Fortified Wines. American Journal Of Enology And ... no increase in ethyl carbamate concentration was found, and that no additional ethyl carbamate precursors were released from ... Ethyl carbamate (EC, urethane) is a naturally occurring component of all fermented foods and beverages. Because EC has shown a ... Determination Of Ethyl Carbamate In Wine By GC-SIM-MS After Continuous Extraction With Diethyl Ether. HRC-Journal Of High ...
Chromatographic and spectral analysis of terpenes and n-alkyl alcohol carbamates, Anal. Chem., 1973, 45, 2, 376-378. [doi: ...
... *Framework for Assessing Health Impacts of ... Interaction Profile for Mixtures of Insecticides: Pyrethroids, Organophosphorus Compounds, and Carbamates. (Draft for Public ... Mixtures of Insecticides: Pyrethroids, Organophosphorus Compounds, and Carbamates. ...
The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. However, NIST makes no warranties to that effect, and NIST shall not be liable for any damage that may result from errors or omissions in the Database ...
Ammonium carbamate is an inorganic compound with the formula NH4[H2NCO2] consisting of ammonium NH+. 4 and carbamate H. 2NCO−. ... 2] Carbamates of other metals, such as calcium, can be produced by reacting ammonium carbamate with a suitable salt of the ... Preparation of metal carbamatesEdit. Ammonium carbamate can be a starting reagent for the production of salts of other cations ... "Ammonium Carbamate" Retrieved October 12, 2012. *^ a b Carl Theodor Thorssell and August Kristensson (1935): "Process for the ...
Pesticides - Carbamates & Organophosphorus Metabolites - Urine (CARB_D) Data File: CARB_D.xpt First Published: February 2013. ... and carbamate metabolites, in particular, AP, MMP, Omet, Dmet, ETU and PTU from a urine matrix. The general sample preparation ... Measures of urinary carbamate and phosphorus pesticides were measured in a one third subsample of persons 6 years and over. ...
Galperin, V.A., Finkelshtein, A.I. Infrared spectra of ammonium carbamate and bicarbonate. J Appl Spectrosc 17, 1176-1178 ( ...
... showing that several carbamates were decomposed rapidly by contact. Recent developments in halamine materials have resulted in ...
Get the latest carbamate detection news on Environmental XPRT, the worlds largest environmental industry marketplace and ... This test method has been developed by US EPA Region 5 Chicago Regional Laboratory (CRL). The N-methyl carbamate (NMC) ... This test method has been developed by US EPA Region 5 Chicago Regional Laboratory (CRL). The N-methyl carbamate (NMC) ... The N-methyl carbamate (NMC) pesticides: aldicarb, carbaryl, carbofuran, formetanate hydrochloride, methiocarb, methomyl, ...
Testing Status of Transgenic LEP (Vinyl carbamate) M970009. CASRN: 15805-73-9. Formula: C3-H5-N-O2. Synonyms/Common Names. * ...
NMR spectra obtained dissolving ammonium carbamate in D2O, in which signals referred to the ions carbamate and bicarbonate/ ... The carbamate ion is unstable in acidic medium and decomposes rapidly into ammonium ion and carbon dioxide. Even at weak acidic ... In a follow-up experiment,13C{1H}-NMRof a 10% solution of ammonium carbamate in D2O (pH 9-9.5) were recorded (BASF SE, ... When ammonium carbamate is dissolved in water a complex chemical equilibrium is established among the species of carbonate, ...
Absorption occurs through all routes Carbamates differ toxicologically from organophoshphates in two ways: 1.They will ...
Contractures produced by carbamate anticholinesterases in bovine tracheal smooth muscle.. Kirkpatrick CT, Rooney PJ. ... 1. In isolated strips of bovine tracheal muscle the carbamate anticholinesterases, neostigmine and eserine caused similar, ...
Organophosphate and Carbamate Poisoning in Infants and Children Message Subject (Your Name) has sent you a message from ... Organophosphate and Carbamate Poisoning in Infants and Children. Robert J. Zwiener and Charles M. Ginsburg ... The clinical and laboratory features of moderate to severe organophosphate and carbamate toxicity in 37 infants and children ...
... a review of all existing EU MRLs for the N-methyl-carbamate insecticides; carbofuran, carbosulfan, benfuracarb and furathiocarb ...
L-cysteinyl carbamate. Regulatory process names 2 IUPAC names 2 Other identifiers 2 ...
ammonium carbamate, ammonium aminoformate, carbamic acid, monoammonium salt, carbamic acid ammonium salt, carbamic acid ... ammonium carbamate, ammonium aminoformate, carbamic acid, monoammonium salt, carbamic acid ammonium salt, carbamic acid ... ammonium carbamate, ammonium aminoformate, carbamic acid, monoammonium salt, carbamic acid ammonium salt, carbamic acid ...
... menthyl carbamate. Finally, the cyclohexyl carbamate derivatives of 9a and 10a were prepared as a control (Scheme 3). ... The carbamate heteroatomic core was varied through the substitution with a thiocarbamate, urea, and thiourea linkages. Tail ... When these compounds were tested on S. aureus and MRSA strains, the most potent inhibitors had contained (−)-menthyl carbamates ... The thymyl and carvacryl carbamate analogues of 9a and 10a were also prepared because they had the lowest IC50 values against ...
We report here the synthesis and characterization of carbamate ester derivatives of resveratrol bearing on each nitrogen atom a ... In vivo pharmacokinetics confirmed absorption after oral administration and showed that no hydrolysis of the carbamate groups ... Keywords: resveratrol; prodrugs; carbamate esters; solubility; poly(ethylene glycol); glucose resveratrol; prodrugs; carbamate ... In vivo pharmacokinetics confirmed absorption after oral administration and showed that no hydrolysis of the carbamate groups ...
To investigate whether carbamate pesticides also induce apoptosis in human T lymphocytes, in the present study Jurkat human T ... These findings indicate that carbamate pesticides can induce apoptosis in human T cells, and the apoptosis is mediated by the ... We previously found that carbamate pesticides induced significant apoptosis in human natural killer cells. ... Carbamate Pesticide-Induced Apoptosis in Human T Lymphocytes. Qing Li * , Maiko Kobayashi. ...
This page contains information on the chemical Carbamate pesticide, liquid, toxic including: 1 synonyms/identifiers; USDOT 2008 ... Carbamate pesticide, liquid, toxic. Identifications. *Synonyms/Related:*Carbamate pesticide, liquid, toxic. 2008 Emergency ... Carbamate pesticide, liquid, toxic (,/a,- This page contains information on the chemical Carbamate ... Carbamate pesticide, liquid, toxic. No. No. Related Resources. *USDOT Hazardous Materials Table 49 CFR 172.101. An online ...
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice ...
Hydrolysis rates (half-life, 25C, pH 7) of carbamates is reported to vary from a few seconds to 105 years; for a primary ... Methyl-N-[3 (trimethoxysilyl)propyl]carbamate hydrolysis rapidly when released in water. The substance has a two-step ... The rate of formation of the first hydrolysis products, methyl-N-[3 (trihydroxysilyl)propyl]carbamate and methanol is ... The initial hydrolysis products are methyl-N-[3-(trihydroxysilyl)propyl]carbamate and methanol. Based on the experimental and ...
US5411967A - Carbamates of rapamycin - Google Patents. Carbamates of rapamycin Download PDF Info. Publication number. ... Carbamates of rapamycin Patent Citations (2). * Cited by examiner, † Cited by third party. Publication number. Priority date. ... Carbamates of rapamycin Cited By (108). * Cited by examiner, † Cited by third party. Publication number. Priority date. ... Use of aryl carbamates in agriculture and other plant-related areas US9918473B2 (en) 2010-09-01. 2018-03-20. North Carolian ...
... Wei Chen, Yuting ... Wei Chen, Yuting Li, Tao Bao, and Vemana Gowd, "Mulberry Fruit Extract Affords Protection against Ethyl Carbamate-Induced ...
Carbamate kinase 2 (arcC2), Carbamate kinase 3 (arcC3), Carbamate kinase 1 (arcC1) ... Carbamate kinase 3 (EC:*Search proteins in UniProtKB for this EC number. ... Belongs to the carbamate kinase family.Curated. Phylogenomic databases. The HOGENOM Database of Homologous Genes from Fully ... sp,Q2FKJ8,ARCC3_STAA3 Carbamate kinase 3 OS=Staphylococcus aureus (strain USA300) OX=367830 GN=arcC3 PE=3 SV=1 ...
More importantly, in an in vivo vinyl carbamate-induced lung cancer model in A/J mice, pre-administration of BHBA significantly ... A curcumin derivative that inhibits vinyl carbamate-induced lung carcinogenesis via activation of the Nrf2 protective response. ...
  • Carbamate Analysis The Alliance System for Carbamate Analysis is a complete system for the analysis of N-methylcarbamate and N-methyl-carbamoyloxine pesticides and related compounds in a variety of environmental and food samples. (
  • Carbamate Analyzer is a system designed to analyze the carbamate pesticides using post column derivatization. (
  • Similar to the organ phosphorus pesticides, the carbamates pesticides also affect the nervous system by disrupting an enzyme that regulates the neurotransmitter. (
  • This is a high-performance liquid chromatographic (HPLC) method applicable to the determination of certain carbamate and urea pesticides in industrial and municipal discharges as provided under 40 CFR 136.1. (
  • Many of the recommendations for chemical nematode control involve organophosphates or carbamates (both effect nerve impulse transmission) and specialized equipment. (
  • Major chemical classes include carbamates, organochlorines, organophosphates (mostly developed 70 or more years ago for chemical warfare) and triazines. (
  • Organophosphates and carbamates are trusted in pest and agriculture avoidance and disrupt nerve function BI-1356 kinase activity assay by inactivating acetylcholinesterase, an enzyme utilized to very clear acetylcholine neurotransmitters from your synapse [40]. (
  • Organophosphate insecticides, applied to cereal crops, accounted for the increase in insecticide use, despite a 94% reduction in the use of carbamates. (
  • however, in other parks like Gonarezhou on the boarder of Zimbabwe and Mozambique, Aldicarb a carbamate insecticide is the most common, along with the harvesting of body parts for muti (traditional medicine). (
  • The Marine Testing Solutions AGRI STICK pesticide test kit, is used for the detection of major organophosphate and carbamate pesticide residues present in agricultural products, soil and water. (
  • The high pressures, high temperatures and the presence of very corrosive ammonium carbamate puts high demands on its reliability and safety during its typical lifetime of 40-50 years. (
  • If you are looking for a supplier or manufacturer of tert-Butyl (4-methylpiperidin-4-yl) carbamate (CAS No.: 163271-08-7) please contact us. (
  • Now, we also hope to meet your needs for tert-Butyl (4-methylpiperidin-4-yl)carbamate (CAS No.:163271-08-7) and other compounds. (
  • I want to know about the product with cas No.: 503524-47-8, Product Name: tert-butyl N-(4-chloro-3-nitrophenyl)carbamate. (
  • In general carbamate esters are referred to as urethanes, and polymers that include repeating units of carbamate are referred to as POLYURETHANES. (
  • S(N)2' reactions of chiral allylic carbamates with organocopper reagents. (
  • A carbamate derivative used to treat alcohol addiction. (
  • A carbamate derivative used as an alcohol deterrent. (

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