The convoluted cordlike structure attached to the posterior of the TESTIS. Epididymis consists of the head (caput), the body (corpus), and the tail (cauda). A network of ducts leaving the testis joins into a common epididymal tubule proper which provides the transport, storage, and maturation of SPERMATOZOA.
The maturing process of SPERMATOZOA after leaving the testicular SEMINIFEROUS TUBULES. Maturation in SPERM MOTILITY and FERTILITY takes place in the EPIDIDYMIS as the sperm migrate from caput epididymis to cauda epididymis.
Mature male germ cells derived from SPERMATIDS. As spermatids move toward the lumen of the SEMINIFEROUS TUBULES, they undergo extensive structural changes including the loss of cytoplasm, condensation of CHROMATIN into the SPERM HEAD, formation of the ACROSOME cap, the SPERM MIDPIECE and the SPERM TAIL that provides motility.
The male gonad containing two functional parts: the SEMINIFEROUS TUBULES for the production and transport of male germ cells (SPERMATOGENESIS) and the interstitial compartment containing LEYDIG CELLS that produce ANDROGENS.
The male reproductive organs. They are divided into the external organs (PENIS; SCROTUM;and URETHRA) and the internal organs (TESTIS; EPIDIDYMIS; VAS DEFERENS; SEMINAL VESICLES; EJACULATORY DUCTS; PROSTATE; and BULBOURETHRAL GLANDS).
The network of channels formed at the termination of the straight SEMINIFEROUS TUBULES in the mediastinum testis. Rete testis channels drain into the efferent ductules that pass into the caput EPIDIDYMIS.
Passive or active movement of SPERMATOZOA from the testicular SEMINIFEROUS TUBULES through the male reproductive tract as well as within the female reproductive tract.
Inflammation of the EPIDIDYMIS. Its clinical features include enlarged epididymis, a swollen SCROTUM; PAIN; PYURIA; and FEVER. It is usually related to infections in the URINARY TRACT, which likely spread to the EPIDIDYMIS through either the VAS DEFERENS or the lymphatics of the SPERMATIC CORD.
Paired ducts in the human male through which semen is ejaculated into the urethra.
Proteins secreted by the epididymal epithelium. These proteins are both tissue- and species-specific. They are important molecular agents in the process of sperm maturation.
Movement characteristics of SPERMATOZOA in a fresh specimen. It is measured as the percentage of sperms that are moving, and as the percentage of sperms with productive flagellar motion such as rapid, linear, and forward progression.
The excretory duct of the testes that carries SPERMATOZOA. It rises from the SCROTUM and joins the SEMINAL VESICLES to form the ejaculatory duct.
Surgical removal of the ductus deferens, or a portion of it. It is done in association with prostatectomy, or to induce infertility. (Dorland, 28th ed)
The process of germ cell development in the male from the primordial germ cells, through SPERMATOGONIA; SPERMATOCYTES; SPERMATIDS; to the mature haploid SPERMATOZOA.
A saclike, glandular diverticulum on each ductus deferens in male vertebrates. It is united with the excretory duct and serves for temporary storage of semen. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
The convoluted tubules in the TESTIS where sperm are produced (SPERMATOGENESIS) and conveyed to the RETE TESTIS. Spermatogenic tubules are composed of developing germ cells and the supporting SERTOLI CELLS.
A count of SPERM in the ejaculum, expressed as number per milliliter.
The surgical removal of one or both testicles.
A potent androgenic steroid and major product secreted by the LEYDIG CELLS of the TESTIS. Its production is stimulated by LUTEINIZING HORMONE from the PITUITARY GLAND. In turn, testosterone exerts feedback control of the pituitary LH and FSH secretion. Depending on the tissues, testosterone can be further converted to DIHYDROTESTOSTERONE or ESTRADIOL.
Liquid components of living organisms.
Value of all final goods and services produced in a country in one year.
Compounds that interact with ANDROGEN RECEPTORS in target tissues to bring about the effects similar to those of TESTOSTERONE. Depending on the target tissues, androgenic effects can be on SEX DIFFERENTIATION; male reproductive organs, SPERMATOGENESIS; secondary male SEX CHARACTERISTICS; LIBIDO; development of muscle mass, strength, and power.
The epithelium lining the seminiferous tubules composed of primary male germ cells (SPERMATOGONIA) and supporting SERTOLI CELLS. As SPERMATOGENESIS proceeds, the developing germ cells migrate toward the lumen. The adluminal compartment, the inner two thirds of the tubules, contains SPERMATOCYTES and the more advanced germ cells.
The posterior filiform portion of the spermatozoon (SPERMATOZOA) that provides sperm motility.
The measurement of an organ in volume, mass, or heaviness.
Achievement of full sexual capacity in animals and in humans.
The thick, yellowish-white, viscid fluid secretion of male reproductive organs discharged upon ejaculation. In addition to reproductive organ secretions, it contains SPERMATOZOA and their nutrient plasma.
The anterior portion of the spermatozoon (SPERMATOZOA) that contains mainly the nucleus with highly compact CHROMATIN material.
Pathological processes of the TESTIS.
Proteins found in SEMEN. Major seminal plasma proteins are secretory proteins from the male sex accessory glands, such as the SEMINAL VESICLES and the PROSTATE. They include the seminal vesicle-specific antigen, an ejaculate clotting protein; and the PROSTATE-SPECIFIC ANTIGEN, a protease and an esterase.
Inflammation of a TESTIS. It has many features of EPIDIDYMITIS, such as swollen SCROTUM; PAIN; PYURIA; and FEVER. It is usually related to infections in the URINARY TRACT, which likely spread to the EPIDIDYMIS and then the TESTIS through either the VAS DEFERENS or the lymphatics of the SPERMATIC CORD.
The inability of the male to effect FERTILIZATION of an OVUM after a specified period of unprotected intercourse. Male sterility is permanent infertility.
The amounts spent by individuals, groups, nations, or private or public organizations for total health care and/or its various components. These amounts may or may not be equivalent to the actual costs (HEALTH CARE COSTS) and may or may not be shared among the patient, insurers, and/or employers.
Surgical anastomosis or fistulization of the spermatic ducts to restore fertility in a previously vasectomized male.
The capacity to conceive or to induce conception. It may refer to either the male or female.
Supporting cells projecting inward from the basement membrane of SEMINIFEROUS TUBULES. They surround and nourish the developing male germ cells and secrete ANDROGEN-BINDING PROTEIN and hormones such as ANTI-MULLERIAN HORMONE. The tight junctions of Sertoli cells with the SPERMATOGONIA and SPERMATOCYTES provide a BLOOD-TESTIS BARRIER.
The emission of SEMEN to the exterior, resulting from the contraction of muscles surrounding the male internal urogenital ducts.
Carrier proteins produced in the Sertoli cells of the testis, secreted into the seminiferous tubules, and transported via the efferent ducts to the epididymis. They participate in the transport of androgens. Androgen-binding protein has the same amino acid sequence as SEX HORMONE-BINDING GLOBULIN. They differ by their sites of synthesis and post-translational oligosaccharide modifications.
A potent androgenic metabolite of TESTOSTERONE. It is produced by the action of the enzyme 3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE.
An ester of TESTOSTERONE with a propionate substitution at the 17-beta position.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
The cap-like structure covering the anterior portion of SPERM HEAD. Acrosome, derived from LYSOSOMES, is a membrane-bound organelle that contains the required hydrolytic and proteolytic enzymes necessary for sperm penetration of the egg in FERTILIZATION.
Surgical removal or artificial destruction of gonads.
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
DEFENSINS found mainly in epithelial cells.
A pair of excretory ducts of the middle kidneys (MESONEPHROI) of an embryo, also called mesonephric ducts. In higher vertebrates, Wolffian ducts persist in the male forming VAS DEFERENS, but atrophy into vestigial structures in the female.
An oviparous burrowing mammal of the order Monotremata native to Australia, Tasmania, and New Guinea. It has hair mingled with spines on the upper part of the body and is adapted for feeding on ants.
Male germ cells derived from the haploid secondary SPERMATOCYTES. Without further division, spermatids undergo structural changes and give rise to SPERMATOZOA.
One or more layers of EPITHELIAL CELLS, supported by the basal lamina, which covers the inner or outer surfaces of the body.
Chemical substances or agents with contraceptive activity in males. Use for male contraceptive agents in general or for which there is no specific heading.
A chlorinated PROPANEDIOL with antifertility activity in males used as a chemosterilant in rodents.
A family of herbivorous leaping MAMMALS of Australia, New Guinea, and adjacent islands. Members include kangaroos, wallabies, quokkas, and wallaroos.
Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.
An anti-androgen that, in the form of its acetate (CYPROTERONE ACETATE), also has progestational properties. It is used in the treatment of hypersexuality in males, as a palliative in prostatic carcinoma, and, in combination with estrogen, for the therapy of severe acne and hirsutism in females.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Either of a pair of tubular structures formed by DUCTUS DEFERENS; ARTERIES; VEINS; LYMPHATIC VESSELS; and nerves. The spermatic cord extends from the deep inguinal ring through the INGUINAL CANAL to the TESTIS in the SCROTUM.
A gland in males that surrounds the neck of the URINARY BLADDER and the URETHRA. It secretes a substance that liquefies coagulated semen. It is situated in the pelvic cavity behind the lower part of the PUBIC SYMPHYSIS, above the deep layer of the triangular ligament, and rests upon the RECTUM.
The structural and functional changes by which SPERMATOZOA become capable of oocyte FERTILIZATION. It normally requires exposing the sperm to the female genital tract for a period of time to bring about increased SPERM MOTILITY and the ACROSOME REACTION before fertilization in the FALLOPIAN TUBES can take place.
A species of macaque monkey that mainly inhabits the forest of southern India. They are also called bonnet macaques or bonnet monkeys.
Pathological processes involving the male reproductive tract (GENITALIA, MALE).
An antiandrogen with about the same potency as cyproterone in rodent and canine species.
A developmental defect in which a TESTIS or both TESTES failed to descend from high in the ABDOMEN to the bottom of the SCROTUM. Testicular descent is essential to normal SPERMATOGENESIS which requires temperature lower than the BODY TEMPERATURE. Cryptorchidism can be subclassified by the location of the maldescended testis.
The unspecified form of the steroid, normally a major metabolite of TESTOSTERONE with androgenic activity. It has been implicated as a regulator of gonadotropin secretion.
The science of utilization, distribution, and consumption of services and materials.
A selective pre- and post-emergence herbicide. (From Merck Index, 11th ed)
Mobilization of human, financial, capital, physical and or natural resources to generate goods and services.
Interactive processes between the oocyte (OVUM) and the sperm (SPERMATOZOA) including sperm adhesion, ACROSOME REACTION, sperm penetration of the ZONA PELLUCIDA, and events leading to FERTILIZATION.
Revenues or receipts accruing from business enterprise, labor, or invested capital.
A cystic dilation of the EPIDIDYMIS, usually in the head portion (caput epididymis). The cyst fluid contains dead SPERMATOZOA and can be easily differentiated from TESTICULAR HYDROCELE and other testicular lesions.
A cutaneous pouch of skin containing the testicles and spermatic cords.
A genus of the family Muridae having three species. The present domesticated strains were developed from individuals brought from Syria. They are widely used in biomedical research.
Steroid-producing cells in the interstitial tissue of the TESTIS. They are under the regulation of PITUITARY HORMONES; LUTEINIZING HORMONE; or interstitial cell-stimulating hormone. TESTOSTERONE is the major androgen (ANDROGENS) produced.
e. Caput epididymis. g. The gubernaculum. i. Lower part of the intestine. m. Müllerian duct, the upper part of which remains as ... In the male the duct persists, and forms the tube of the epididymis, the vas deferens and the ejaculatory duct, while the ... t', together with the dotted lines above, indicates the direction in which the testis and epididymis descend from the abdomen ... which is sometimes found in front of the spermatic cord above the head of the epididymis. In the female the mesonephric bodies ...
e. Caput epididymis. g. The gubernaculum. i. Lower part of the intestine. m. Müllerian duct, the upper part of which remains as ... t', together with the dotted lines above, indicates the direction in which the testis and epididymis descend from the abdomen ... In the male the Wolffian duct persists, and forms for example the epididymis, the ductus deferens, the ejaculatory duct, ...
Expression of ADAM7 is higher in the head (Caput) of the epididymis and decreases in cells towards the distal epididymis. ADAM7 ... Secretion in this manner is an apocrine secretion in which apical blebs containing a portion of the epididymis cell are ... ADAM7 is secreted by epididymis cells and transferred to the maturing sperm's surface. As determined through mouse gene knock- ... ADAM7 is synthesized in epididymis cells and transferred to the membrane of immature sperm cells as they traverse the ...
The epididymis can be divided into three main regions: The head (Latin: caput). The head of the epididymis receives spermatozoa ... Sperm entering the caput epididymis are incomplete-they lack the ability to swim forward (motility) and to fertilize an egg. ... Spermatozoa formed in the testis enter the caput epididymis, progress to the corpus, and finally reach the cauda region, where ... The epididymis (/ɛpɪˈdɪdɪmɪs/; plural: epididymides /ɛpɪdɪˈdɪmədiːz/ or /ɛpɪˈdɪdəmɪdiːz/) is a tube that connects a testicle to ...
Sperm made in the testis go into the head (caput) of the epididymis, go through the body (corpus) and stop at the tail (cauda ... Epididymis. Adult human testicle with epididymis: A. Head of epididymis, B. Body of epididymis, C. Tail of epididymis, and D. ... The epididymis is the part of the human male reproductive system. It is the tube that holds the testicles in place. It ... Jones R (1999). "To store or mature spermatozoa The primary role of the epididymis". Int J Androl. 22 (2): 57-67. doi:10.1046/j ...
މަނި ގުދަން ނުވަތަ(އިނގިރޭސި ބަހުން: Epididymis)މިއީ އޮށުގެ ފަހަތުގައި ތަތްވެފައި އިންނަ އޮޅިފައިވާ ހޮޅިއެކެވެ. މަނި ގުދަން ... ބޯ(Head / Caput). *ހަށިގަނޑު(Body/Corpus). *ނިގޫ(Tail/Cauda). އޮށުގެ ތެރޭގައި އުފެދޭ މަނި އެންމެ ފުރަތަމަ ވަންނަނީ މަނި ... ވަށައިގެން މަޑުމަހުގެ ފަށަލައެއް ލެވިފައިވާ މިހޮޅި އަކީ ކަނާތް ފަރާތު އަދި ވާތް ފަރާތުގައިވާ މަނި ހޮޅީގެ ފެށޭބައި(Epididymis) ...
Jones R (1999). "To store or mature spermatozoa The primary role of the epididymis". Int J Androl 22 (2): 57-67. doi:10.1046/j. ... Mae sberm, sy'n cael ei gynhyrchu yn y ceilliau, yn mynd i mewn i ben (caput) yr argaill, drwy'r corff (corpus) i'r gynffon ( ... Pan fydd sberm yn cael eu halldaflu, maent yn symud trwy gynffon yr epididymis. Mae cymaint o sberm yn ceisio symud trwy le ... Mae'r argaill (neu'r 'epididymis') yn rhan o'r system atgenhedlu wrywaidd. Mae'n diwb sy'n cysylltu'r ceilliau i'r fas ...
Rejraji H, Vernet P, Drevet JR (2002). "GPX5 is present in the mouse caput and cauda epididymidis lumen at three different ... It is specifically expressed in the epididymis in the mammalian male reproductive tract, and is androgen-regulated. Unlike ... a murine epididymis-specific glutathione peroxidase". Mol. Reprod. Dev. 47 (1): 87-98. doi:10.1002/(SICI)1098-2795(199705)47:1 ...
... calf calix calvaria calyx canal of Schlemm canaliculus cancellous canine tooth canthus capillary capitate capitulum caput caput ... endothelium enkephalin entorhinal cortex ependyma epicanthus epicardium epicondyle epicranial aponeurosis epidermis epididymis ...
Cornwall GA, Hann SR (Aug 1995). "Transient appearance of CRES protein during spermatogenesis and caput epididymal sperm ... gene related to the cystatin family is highly restricted in its expression to the proximal region of the mouse epididymis". Mol ...
e. Caput epididymis.. *g. The gubernaculum.. *i. Lower part of the intestine. ... In the male the duct persists, and forms the tube of the epididymis, the vas deferens and the ejaculatory duct, while the ... t', together with the dotted lines above, indicates the direction in which the testis and epididymis descend from the abdomen ... which is sometimes found in front of the spermatic cord above the head of the epididymis. ...
Histology and histochemistry of caput and corpus epididymis in calves and adult buffaloes ... Analysis of characteristics and cryosurvival of sperm from the caput, corpus and cauda epididymis of the domestic dog. Biology ... Different expression of B7-H3 in the caput, corpus, and cauda of the epididymis in mouse. Bmc Urology 17(1): 23-23, 2017 ... Comparative study of boar sperm coming from the caput, corpus, and cauda regions of the epididymis. Journal Of Andrology. 16(2 ...
Comparative study of boar sperm coming from the caput, corpus, and cauda regions of the epididymis ... Pathogenetic transition in the morphology of abnormal sperm in the testes and the caput, corpus, and cauda epididymides of male ... Analysis of characteristics and cryosurvival of sperm from the caput, corpus and cauda epididymis of the domestic dog. Biology ... Different expression of B7-H3 in the caput, corpus, and cauda of the epididymis in mouse. Bmc Urology 17(1): 23, 2017 ...
Expression profiles of human epididymis epithelial cells reveal the functional diversity of caput, corpus and cauda regions. ... Expression profiles of human epididymis epithelial cells reveal the functional diversity of caput, corpus and cauda regions ... between tissues and cells from the caput, corpus and cauda. MAIN RESULTS AND THE ROLE OF CHANCE: The data showed that the caput ... LIMITATIONS, REASONS FOR CAUTION: Cultured caput, corpus and cauda cells may not faithfully represent the same cells in the ...
The epididymis can be divided into three main regions: *The head (Latin: caput). The head of the epididymis receives ... Epididymis. Adult human testicle with epididymis: A. Head of epididymis, B. Body of epididymis, C. Tail of epididymis, and D. ... The epididymis (/ɛpɪˈdɪdɪmɪs/; plural: epididymides /ɛpɪdɪˈdɪmədiːz/ or /ɛpɪˈdɪdəmɪdiːz/) is a tube that connects a testicle to ... Sperm entering the caput epididymis are incomplete-they lack the ability to swim forward (motility) and to fertilize an egg. ...
e. Caput epididymis.. *g. The gubernaculum.. *i. Lower part of the intestine. ... In the male the duct persists, and forms the tube of the epididymis, the vas deferens and the ejaculatory duct, while the ... t, together with the dotted lines above, indicates the direction in which the testis and epididymis descend from the abdomen ... which is sometimes found in front of the spermatic cord above the head of the epididymis. ...
e. Caput epididymis. g. The gubernaculum. i. Lower part of the intestine. m. Müllerian duct, the upper part of which remains as ... t, together with the dotted lines above, indicates the direction in which the testis and epididymis descend from the abdomen ... In the male the Wolffian duct persists, and forms for example the epididymis, the ductus deferens, the ejaculatory duct, ...
Our aim was to investigate the expression of B7-H3 in the caput, corpus, and cauda of the epididymis. We extracted epididymis ... Moreover, the level of B7-H3 in the corpus of the mouse epididymis was significantly higher than that in the caput (p , 0.05) ... The caput, corpus, and cauda of the mouse epididymis all expressed B7-H3 protein. However, the levels of B7-H3 were different ... or the cauda of the epididymis (P , 0.05). However, there was no remarkable difference in the level of B7-H3 between the caput ...
... of bilateral longitudinal diameter of caput epididymis (mm) (Caput-M) and of the bilateral antero-posterior diameter of the ... of bilateral longitudinal diameter of caput epididymis (mm) (Caput-M) and of the bilateral antero-posterior diameter of the ... Ultrasonographic determination of caput epididymis diameter is strongly predictive of obstruction in the genital tract in ... Ultrasonographic determination of caput epididymis diameter is strongly predictive of obstruction in the genital tract in ...
Since the caput epididymis plays a role in the maturation of sperm cells, our data may be an indication that β-HEX activity in ... Since the caput epididymis plays a role in the maturation of sperm cells, our data may be an indication that β-HEX activity in ... Blood testosterone levels are correlated with β-N-acetylhexosaminidase activity in human caput epididymis. ... Blood testosterone levels are correlated with β-N-acetylhexosaminidase activity in human caput epididymis ...
B7-H3CaputCorpusCaudaEpididymisSperm maturationMouse. Background. The epididymis is a storage organ of sperm and is related to ... Mouse testis and epididymis. The epididymis was subdivided into 10 segments (1-10): 1-5, caput; 6-7, corpus; 8-10, cauda ... a Section from the caput of the epididymis (magnification: [a] ×400); b Section from the corpus of the epididymis(magnification ... Different levels of B7-H3 in the three regions of the epididymis. As shown in Fig. 3, the levels of B7-H3 in the caput, corpus ...
A comparative study on spermatozoa and fluid from caput, corpus and cauda epididymis revealed 6.5-fold increase of activity in ... Phosphoinositide specific phospholipase C activity of goat spermatozoa in transit from the caput to the cauda epididymis. ... Phosphoinositide specific phospholipase C activity of goat spermatozoa in transit from the caput to the cauda epididymis. ... Goat sperm lysate from cauda epididymis was incubated in the presence of [14C]phosphatidyl-choline, -ethanolamine, -inositol ...
Sperm made in the testis go into the head (caput) of the epididymis, go through the body (corpus) and stop at the tail (cauda ... Epididymis. Adult human testicle with epididymis: A. Head of epididymis, B. Body of epididymis, C. Tail of epididymis, and D. ... The epididymis is the part of the human male reproductive system. It is the tube that holds the testicles in place. It ... Jones R (1999). "To store or mature spermatozoa The primary role of the epididymis". Int J Androl. 22 (2): 57-67. doi:10.1046/j ...
The transit of mammalian spermatozoa from caput to cauda epididymis is a sequence of rather complex maturation processes, ... when sperm pass from the caput to the cauda of the epididymis. This would indicate an active lipid metabolism of the ... which occur in the sperm cells plasma and acrosomal membranes during the passage from caput to cauda epididymis (higher PUFA ... in comparison to the caput epididymis spermatozoa corresponding value The binding of PHGPx to the different epididymal sperm ...
... inflammation of the epididymis; see the image below) is a significant cause of morbidity and is the fifth most common urologic ... A: Caput or head of the epididymis. B: Corpus or body of the epididymis. C: Cauda or tail of the epididymis. D: Vas deferens. E ... The epididymis is not tender. Orchitis is found in association with acute epididymitis in 20-40% of cases. ... Color Doppler sonogram of the left epididymis in a patient with acute epididymitis. The image demonstrates increased blood flow ...
We identified the androgen receptor binding sites (ARBSs) of Fut2, Fut4 and Fut9 in the caput epididymis. Luciferase assay for ... while Fut2 mRNA and Fut9 mRNA were downregulated by androgen in the caput epididymis. However, in the vas deferens and prostate ... while Fut2 and Fut9 mRNAs Are Downregulated by Androgen in the Mouse Caput Epididymis. The epididymis is an androgen-responsive ... In mouse caput epididymis, Fut1 mRNA and Fut4 mRNA are upregulated (Figure 1E), while Fut2 mRNA and Fut9 mRNA are downregulated ...
E: epididymis (CA: caput, CO: corpus; CU: cauda). T: testis Other human epididymis _ specific gene products (Table 3) HUMAN ... E: epididymis (CA: caput, CO: corpus; CU: cauda). T: testis 4A8 The monoclonal antibody (mAb) named mAb4A8 was selected for its ... E: epididymis (CA: caput, CO: corpus; CU: cauda). T: testis SOB2 The Sperm Oocyte Binding 2 protein (SOB2) has been purified ... The epididymis, a single convoluted duct, has been grossly divided into three major regions: caput, corpus, and cauda: they ...
ENSG00000112796, Expressed in caput epididymis and 193 other tissues. Genevisible search portal to normalized and curated ...
The caput epididymis showed fewer changes than the cauda. However, epithelial cell nuclear pyknosis and absence of luminal ... Testis and epididymis (caput) were investigated for ultrastructural details of spermatids and spermatozoa. RESULTS-A wide ... "Studies on the beneficial effects of vitamins E and D supplementation on functions of caput and cauda epididymides, their ... Adenosine triposphatase activity, protein, and sialic acid levels in caput and cauda epididymides also showed a decrease. All ...
ENSG00000140443, Expressed in caput epididymis and 242 other tissues. ExpressionAtlasi. H0YNR0, baseline and differential. ...
cystic masses, arise from caput of epididymis. measuring between 2-5cm in diameter. usu do not cause symptoms ...
The persisting remnants of the cranial portion of the mesonephric ducts in males are known as the appendix of the epididymis or ... In males, the epigenital mesonephric tubules develop into the ductuli efferentes of the epididymis (Fig. 13 and Fig. 14). The ... 41 Its principal role is to support the growth of the epididymis and ductus deferens and to control (after conversion to ... the mesonephric ducts give rise to the ductus epididymis, ductus deferens, and ductus ejaculatorius. The vesicular glands are ...
We systematically identified 32 novel genes with epididymis-specific or -predominant expression in the mouse epididymis UniGene ... We identified and characterized 32 novel epididymis-specific or -predominant genes by an integrative approach. Our study is ... and should be a firm basis for future investigation into molecular mechanisms underlying sperm maturation in the epididymis. ... understanding of sperm maturation requires identification and characterization of unique genes expressed in the epididymis. ...
Alterations in Gene Expression in the Caput Epididymides of Nonobstructive Azoospermic Men ... For the human epididymis, little information exists about the regulation of these proteins in male infertility. Our objectives ... Spermatozoal maturation in the epididymis is dependent on proteins secreted by the epithelium and those that create the proper ... With microarrays, we identified 414 genes in the caput epididymidis that were differentially regulated in infertile men by at ...
Sperm entering the caput epididymis are incomplete - they lack the ability to swim forward (motility) and to fertilize an egg. ... 1: Epididymis. 2: Head of epididymis. 3: Lobules of epididymis. 4: Body of epididymis. 5: Tail of epididymis. 6: Duct of ... Spermatozoa formed in the testis enter the caput epididymis, progress to the corpus, and finally reach the cauda region, where ... The epididymis is part of the human male reproductive system and is present in all male mammals. It is a narrow, tightly-coiled ...
The caput epididymis responded to the fathers stress by altering the content of these vesicles. ... In the male reproductive tract, the caput epididymis, the structure where sperm matures, releases tiny vesicles packed with ...
abnormal epididymis morphology*17/20 mice exhibit a abnormal morphology from corpus to caput ... abnormal cauda epididymis morphology*epididymis exhibits a widening of the cauda in 17/20 mice ... Significantly reduced mRNA levels are detected by real-time quantitative RT-PCR of epididymides, ductus deferens and uterus ... Homozygous males exhibit reduced fertility due to structural abnormalities of the epididymis, resulting in a decrease in viable ...
3. Sperm Maturation in the Epididymis. Along each testicle is an epididymis and vas deferens (vas) that make up the network of ... One such molecule is a 135-150 kDa glycoconjugate that is lost from the caput spermatozoa as the cells reach the caudal region ... The epididymides are a set of two coiled tubes, one from each testicle, where testicular spermatozoa undergo many biochemical ... R. Jones, "Membrane remodeling during sperm maturation in the epididymis," in ,Oxford Reviews of Reproductive Biology, S. ...
EDB treatment significantly depressed GSH at 2 hours in caput and cauda epididymis but not in the testes. Trimethyl-phosphate ( ... At 8 and 16 hours post injection BSO treatment significantly depressed GSH in the epididymis and testes. ...
Tissue specificity: Expressed in epididymis, predominantly in the caput (at protein level). ...
  • In particular, it controls the luminal environment in the epididymis, which is required for normal sperm maturation and reproductive competence. (luriechildrens.org)
  • They may also reveal the mechanisms coordinating epididymis luminal environment and sperm maturation. (luriechildrens.org)
  • During their transit in the epididymis, sperm undergo maturation processes necessary for them to acquire motility and fertility. (wikipedia.org)
  • B7-H3, a member of the B7 family of the Ig superfamily of proteins, has been detected in the epididymis, which is a storage organ related to sperm maturation. (biomedcentral.com)
  • The epididymis provides a specific environment which plays an essential role in promoting the final maturation of sperm [ 2 ]. (biomedcentral.com)
  • Since the caput epididymis plays a role in the maturation of sperm cells, our data may be an indication that β-HEX activity in the caput has a physiological relevance in human epididymis functions. (unipg.it)
  • The complete maturation of the sperm cell membrane is attained after testicular lipid biosynthetic processes and after passage through the epididymis. (bioscience.org)
  • In addition to this role of the epididymis on sperm maturation, a system of regulated storage of spermatozoa in the distal region of the organ has been developed in mammals, ensuring that the stored cells are quiescent and unreactive ( Bedford and Yanagimachi, 1991 ). (scielo.cl)
  • Maturation of spermatozoa, including development of motility and the ability to fertilize the oocyte, occurs during transit through the microenvironment of the epididymis. (biomedcentral.com)
  • Comprehensive understanding of sperm maturation requires identification and characterization of unique genes expressed in the epididymis. (biomedcentral.com)
  • Our study is unique in the aspect of systematic identification of novel epididymal genes and should be a firm basis for future investigation into molecular mechanisms underlying sperm maturation in the epididymis. (biomedcentral.com)
  • Therefore, post-testicular maturation of sperm is not under the control of the germinal genome but rather it is mediated by factors within the lumen of the epididymis. (biomedcentral.com)
  • We have characterized the expression of α 1 -adrenoceptor in epididymis from rats in different stages of sexual maturation: 40 (immature), 60 (young adult), and 120 (adult) days of age. (bioone.org)
  • Differences in pK i values in caput and cauda epididymis from immature and adult animals also suggested that the relative amount of α 1 -adrenoceptors, at the protein level, is modulated by sexual maturation. (bioone.org)
  • The epididymis assists sperm maturation to provide sperm with microenvironment successively changing from caput to cauda. (nii.ac.jp)
  • They become functional only after traversing the epididymis and the additional maturation process that it entails. (health.am)
  • Damm O, Cooper T. Maturation of sperm volume regulation in the rat epididymis. (labome.org)
  • Our previous studies in the domestic cat demonstrated that incidence of cenexin-a key protein involved in the centrosomal maturation-progressively increases in sperm cells from caput to cauda epididymidis. (springer.com)
  • After spermiation, sperm are released into the epididymis where they undergo maturation and are stored until ejaculation. (biologists.org)
  • The majority of beta-defensin family members are exclusively expressed in the epididymis, and some members have been shown to play essential roles in sperm maturation and fertility in rats, mice and humans. (biomedcentral.com)
  • HE6 is specifically expressed within the efferent ductules and the initial segment of the epididymis, ductal systems involved in spermatozoon maturation. (asm.org)
  • Although the molecular basis of this maturation process is as yet poorly understood, analyses of gene expression within the epididymis have revealed the identities of many secretory proteins ( 18 , 22 ) that potentially interact with and modify the sperm surface, enabling the mature spermatozoa to develop. (asm.org)
  • The proximal epididymis and efferent ductules have a further function in the reabsorption of testicular fluid, concentrating the spermatozoa and establishing an adequate milieu for maturation of the spermatozoa ( 37 ). (asm.org)
  • This study reports the gene expression and immunolocalization of the low-affinity neurotrophin receptor, p75, in accessory glands (prostate and bulbourethral glands) and epididymis (caput and cauda) of male rabbits during sexual maturation. (upm.es)
  • Significant changes were noted in ion concentrations of cauda and caput of epididymis with changes in protein profile of the tissue, sperm and luminal protein from cauda and caput region, which plays a significant role in sperm maturation and sperm transport. (ijpsonline.com)
  • As a member of the CRES subfamily, Cystatin 8 is a 142 amino acid protein that is expressed in the proximal caput region of the epididymis, where it performs a specialized role during sperm development and maturation. (thermofisher.com)
  • Overall, these results show that the levels of miR-890/miR-891a/miR-891b/ miR-892a /miR-892b and miR-205 , previously reported to be primarily expressed in reproductive tissues, are present at high levels in the distal region of the epididymis, suggesting a role of these microRNAs in the later stages of epididymal sperm maturation or storage. (mirbase.org)
  • Of these, 5 members of the miR-888 cluster (miR-890, miR-891a/b , miR-892a /b) were significantly more abundant in the corpus/cauda regions of the epididymis, suggesting a role in the regulation of the later stages of epididymal sperm maturation. (mirbase.org)
  • At 8 and 16 hours post injection BSO treatment significantly depressed GSH in the epididymis and testes. (cdc.gov)
  • EDB treatment significantly depressed GSH at 2 hours in caput and cauda epididymis but not in the testes. (cdc.gov)
  • The epididymis was observed to be highly convoluted at the cranial aspect of each testis as the catput epididymis, the medial aspects of the testis as the corpus epididymis and caudal aspects of the testes as the caudal epididymis. (pulsus.com)
  • he mammalian epididymis is an exceptionally long, convoluted ductal system that serves to connect the ductuli efferentes, which drain the testes, to the ductus deferens. (pulsus.com)
  • Spermatozoa were harvested from three fertile boars and reproductive tract (testes and epididymis) and sex accessory gland (prostate and seminal vesicles) tissues were collected post-mortem from each boar. (unboundmedicine.com)
  • An image depicting the testes and epididymis can be seen below. (medscape.com)
  • The tunica vaginalis testis (a remnant of the processus vaginalis) envelopes the testis in a double layer, except at the superior and posterior borders, where the spermatic cord and epididymis adhere to the testes. (medscape.com)
  • Epididymides were dissected from adult cat testes to assess the presence and localization of cenexin in testicular tissues and each epididymal segment (caput, corpus, and cauda) via immunofluorescence, Western blot, and mass spectrometry. (springer.com)
  • In the present study, treatment with plumieride caused a significant reduction in sperm density of cauda epididymis as well as testes. (thefreedictionary.com)
  • Peripubertal rats (8-10 weeks) and mice (5-7 weeks) may have normal-appearing testes, normal amounts of sperm in the caput and corpus, but reduced amounts of sperm in the cauda because they have not built up full sperm reserves. (nih.gov)
  • At sacrifice, after 27 weeks of BA exposure, the F0 males fed 9000 ppm BA had significantly lower body weight and reproductive organ weights (testes, combined caput and corpus epididymis. (nih.gov)
  • Males fed 4500 ppm BA also had significantly lower testes, epididymis, prostate weight. (nih.gov)
  • Ultrastructural examination reveals a defect in microtubule structure of the axoneme with increased disintegration in mutant derived sperm present in the epididymis cauda region, but not in caput region or testes. (prolekare.cz)
  • The testes, epididymides and ducti deferentia were removed quickly and placed in Petri dishes. (docme.ru)
  • Thus, the purpose of this study is to describe morphologically the regional histology of the ductus epididymidis in the dog, to provide a detailed structural baseline for specific studies of functional zonation in the epididymis of the dog, or, to comparate to other mammals. (scielo.cl)
  • Quantitation of enzyme activity in isolated ductal segments showed that Na$\sp+$,K$\sp+$-ATPase is differentially distributed in four locations examined: highest in the proximal ductuli efferentes and initial segment of the epididymis, intermediate in the caput epididymidis and lowest in the conus region of the ductuli efferentes. (illinois.edu)
  • This was based on observations that abnormal sperm were ubiquitin-labelled and that the percentage of ubiquitin-labelled sperm decreased from 5% in the caput to 1% in the cauda epididymidis of two animals. (biologists.org)
  • Little change in motility occurs until the sperm reach the flexure of the caput epididymidis where some are capable of moving more vigorously in a circular fashion. (docme.ru)
  • Samples from the distal caput epididymidis show a sudden increase in sperm activity and a consistent pattern of tight, circular movement. (docme.ru)
  • Recently Blandau and Rumery ('64) demonstrated that rat spermatozoa taken from the caput epididymidis swim in a circular fashion whereas those taken from the cauda tend to move in straight lines. (docme.ru)
  • Connective tissue and blood vessels were cut away and the fat pad over the caput epididymidis was dissected with iridectomy scissors to expose the ductuli efferentes and the various components of the caput epididymidis. (docme.ru)
  • They are also preferentially expressed in postmeiotic germ cells, the proximal caput epididymidis, and anterior pituitary gonadotrophs. (thermofisher.com)
  • In contrast to miR-892a , the expression of Spag8 was significantly decreased in the corpus and cauda relative to the caput epididymidis (Fig. S3). (mirbase.org)
  • The incidence of spermatozoa with the head detached from the tail remained stable in the first two regions of the epididymis, increasing notably in the cauda. (eurekamag.com)
  • The percent of mature spermatozoa and aberrant spermatozoa increased from the Caput to the cauda, whereas the percent of immature spermatozoa decreased. (eurekamag.com)
  • The acrosomal protuberance was highly developed in spermatozoa from the epididymal caput, but its volume was considerably reduced in those from the epididymal cauda. (eurekamag.com)
  • The electron density of the acrosomal content was lower in spermatozoa from the caput than in those from the epididymal cauda. (eurekamag.com)
  • The mitochondrial sheath of spermatozoa from the caput was made of voluminous mitochondria of unequal size, with a low electron-dense matrix. (eurekamag.com)
  • The head of the epididymis receives spermatozoa via the efferent ducts of the mediastinium of the testis . (wikipedia.org)
  • Spermatozoa formed in the testis enter the caput epididymis, progress to the corpus, and finally reach the cauda region, where they are stored. (wikipedia.org)
  • IMSEAR at SEARO: Phosphoinositide specific phospholipase C activity of goat spermatozoa in transit from the caput to the cauda epididymis. (who.int)
  • A comparative study on spermatozoa and fluid from caput, corpus and cauda epididymis revealed 6.5-fold increase of activity in spermatozoa and a 4-fold decrease in case of fluid during the epididymal transit. (who.int)
  • This luminal compartment of the epididymis stores the spermatozoa until ejaculation. (pulsus.com)
  • Not only does the epididymis preserve the spermatozoa, it also prepares the spermatozoa for fertilization by providing the essential requirements in terms of temperature, oxygen tension, pH and an available energy substrate [ 1 ]. (pulsus.com)
  • Epididymis ducts were sectioned into caput, corpus, and cauda regions, and spermatozoa were mechanically collected. (unboundmedicine.com)
  • The objectives of the study were to (1) characterize mechanisms involved in transferring key factors-using the cenexin as a marker-between the epididymis and maturing sperm cells and (2) demonstrate the impact of such mechanisms on the acquisition of functional properties by spermatozoa. (springer.com)
  • An intense reactivity for AQP1 was noted over the microvilli of principal cells and in spermatozoa in the caput. (ovid.com)
  • In patients with OA, although normal spermatogenesis is preserved, the quality of spermatozoa may be altered because the distal epididymis contains a high number of sperm fragments with macrophages (9). (scielo.br)
  • Spermatozoa damage may take place within the testis, epididymis or ejaculates. (scirp.org)
  • Several investigators, however, have shown that although in the unobstructed setting sperm quality improves as the spermatozoa travel from caput (head) to cauda (tail) epididymis, this is not true in the obstructed situation. (maleinfertility.org)
  • This work identifies a lumicrine system essential for testis-epididymis-spermatozoa (NELL2-ROS1-OVCH2-ADAM3) signaling and male fertility. (bvsalud.org)
  • In mouse epididymis, IDO2 is expressed in the tails of spermatozoa while IDO1 is expressed in the principal and apical cells of the caput epididymis. (atlasgeneticsoncology.org)
  • and cauda epididymis) and significantly fewer spermatozoa in the cauda epididymis. (nih.gov)
  • Spermatozoa, produced in the seminiferous tubules of the testis, are passed via the rete testis through the efferent ductules to the epididymis. (asm.org)
  • For it to be valid, two important points need to be established: a loss of sperm in the epididymis and the removal of abnormal spermatozoa by its epithelium. (biologists.org)
  • Although spermiophagy normally is not seen in the epididymis of all mammals thus far investigated, under certain conditions such as after obstruction or during advanced ageing, spermatozoa can be rarely seen in the cells of the epididymal epithelium. (biologists.org)
  • presents unconvincing evidence for removal of defective spermatozoa by the normal epididymis and that the data certainly cannot be interpreted as a role for the epididymis in control of sperm quality. (biologists.org)
  • Studies on resorption of ( 3 H) thymidine-labeled spermatozoa in the epididymis. (biologists.org)
  • These data provide support for IDO playing a hitherto unsuspected role in sperm quality control in the epididymis involving the ubiquitination of defective spermatozoa and their subsequent removal. (uni-regensburg.de)
  • It is concluded that rabbit spermatozoa undergo a distinct sequence of changes in their swimming movements as they mature in the epididymis. (docme.ru)
  • When caput spermatozoa were inseminated into the cornu they did not go through the utero-tuba1 junction into the oviduct and thus the number of fertilized eggs was negligible. (docme.ru)
  • In the male the duct persists, and forms the tube of the epididymis , the vas deferens and the ejaculatory duct , while the seminal vesicle arises during the third month as a lateral diverticulum from its hinder end. (wikipedia.org)
  • In the male the Wolffian duct persists, and forms for example the epididymis, the ductus deferens, the ejaculatory duct, seminal vesicle and efferent ducts. (wikipedia.org)
  • Homozygous males exhibit reduced fertility due to structural abnormalities of the epididymis, resulting in a decrease in viable sperm exiting the vas deferens. (jax.org)
  • Significantly reduced mRNA levels are detected by real-time quantitative RT-PCR of epididymides, ductus deferens and uterus tissue, and by in situ hybridization in the uterus. (jax.org)
  • plural: epididymides /ɛpɪdɪˈdɪmədiːz/ or /ɛpɪˈdɪdəmɪdiːz/) is a tube that connects a testicle to a vas deferens in the male reproductive system. (wikipedia.org)
  • During ejaculation, sperm flow from the cauda epididymis (which functions as a storage reservoir) into the vas deferens where they are propelled by the peristaltic action of muscle layers in the wall of the vas deferens, and are mixed with the diluting fluids of the prostate, seminal vesicles, and other accessory glands prior to ejaculation (forming semen). (wikipedia.org)
  • Epithelial basal cells exhibited the highest relaxin immunofluorescence intensity within the epididymis and the vas deferens. (unboundmedicine.com)
  • The luminal immunoreactivity to relaxin was detected in the seminiferous tubule, epididymis, and vas deferens ducts. (unboundmedicine.com)
  • At the same time we determined TEX101 localization in epididymis and was deferens of adult mouse. (nii.ac.jp)
  • Sperm in the epididymis and was deferens did not show TEX101 immunoreativity, although sperm in testis showed intense staining for TEX101. (nii.ac.jp)
  • Thus, sperm may loose TEX101 protein while sperm move from the testis to epididymis, and finally to was deferens. (nii.ac.jp)
  • The visceral layer of the tunica vaginalis testis is closely applied to the testis, epididymis, and ductus deferens. (medscape.com)
  • The inferior portion of the epididymis that is continuous with the ductus deferens. (thefreedictionary.com)
  • These tubules merge into a larger tube called the epididymis that leads out of the testis into the vas deferens. (thefreedictionary.com)
  • SPAM1 protein is present in all three regions of the epididymis, as well as the vas deferens, and is localized similarly to the transcripts.SPAM1 was shown to have hyaluronidase activity at pH 7.0.These findings allow us to conclude that epididymal SPAM1 is conserved in at least two mammalian classes, rodents and primates. (nih.gov)
  • SPAM1 protein is present in all three regions of the epididymis, as well as the vas deferens, and is localized similarly to the transcripts. (nih.gov)
  • The mammalian epididymis is a segmented organ comprised of a single highly convoluted tubule divided into four regions: the initial segment, caput, corpus, and cauda regions. (biomedcentral.com)
  • Nicander L, Malmqvist M. Ultrastructural observations suggesting merocrine secretion in the initial segment of the mammalian epididymis. (springer.com)
  • The Mammalian Epididymis. (biologists.org)
  • Intriguingly, IDO is constitutively and highly expressed in the mammalian epididymis in contrast to most other tissues where IDO is induced by proinflammatory cytokines, such as interferons. (uni-regensburg.de)
  • To gain insight into the role of IDO in the physiology of the mammalian epididymis, we studied both wild type and Ido1(-/-)-deficient mice. (uni-regensburg.de)
  • STUDY DESIGN, SAMPLES/MATERIALS, METHODS: Using RNA sequencing on biological replicates, we described gene expression profiles for tissue from each region of the epididymis and cultured epithelial cells derived from these regions. (luriechildrens.org)
  • STUDY HYPOTHESIS: Region-specific transcriptional profiling of tissues and cultured epithelial cells from the human epididymis will predict functional specialization along the duct. (luriechildrens.org)
  • The epididymis, a single convoluted duct, has been grossly divided into three major regions: caput, corpus, and cauda: they have been primarily distinguished by their epithelial cell morphology, their sperm fertilizing ability, and more recently, by their specific pattern of gene expression. (scielo.cl)
  • A novel transcriptional network for the androgen receptor in human epididymis epithelial cells. (nih.gov)
  • The expression of FSH receptor (FSH-R) was detected also in epithelial cells of the caput epididymis of rat and monkey. (hindawi.com)
  • Additionally, we presented that the morphology of rat epididymal epithelial cells in vitro was affected by FSH, and FSH stimulation resulted in the increase of 17 -estradiol synthesis by rat caput epididymal cells in dose-depended manner. (hindawi.com)
  • 2012) found spermatic granuloma, cell debris, epithelial cell vacuolization and oligospermia in proximal caput epididymis of adult rats after treatment with 10 mg [kg. (thefreedictionary.com)
  • 1991) reported changes in the epithelial lining of the epididymis, when the dog became sexually mature. (scielo.cl)
  • AQP1 immunoreactivity was observed in the apex of the ED, and AQP9 was found adjacent to the nuclei of the epithelial cells of the ED. The epithelial lining of ram epididymis is pseudostratified columnar and presents principal, basal, apical and narrow cells. (ovid.com)
  • A weak-to-moderate reaction for AQP9 was observed in the nuclei of epithelial cells in the IS, caput and corpus of the epididymis. (ovid.com)
  • In vitro, DHT did not modify NO production by the epithelial cells of the caput epididymis even when stimulated with LPS and IFNγ, but it did give rise to an increase in NO production by the epithelial cells of the cauda epididymis without the stimulation. (degruyter.com)
  • DHT did not have a statistically significant influence on estradiol production by cultured, LPS- and IFNγ-stimulated epithelial cells from the caput and cauda epididymis. (degruyter.com)
  • These results suggest that the 23kDa protein is specifically expressed in the proximal caput epididymis, secreted into the lumen and then binds to the surface of maturating sperm. (nii.ac.jp)
  • The caput, corpus, and cauda of the mouse epididymis all expressed B7-H3 protein. (biomedcentral.com)
  • Due to these findings, we focused on: (1) whether B7-H3 is expressed in all regions of the mouse epididymis, and (2) whether the levels of B7-H3 expressed in the caput, corpus, and cauda of the mouse epididymis are different. (biomedcentral.com)
  • We systematically identified 32 novel genes with epididymis-specific or -predominant expression in the mouse epididymis UniGene library, containing 1505 gene-oriented transcript clusters, by in silico and in vitro analyses. (biomedcentral.com)
  • The primary role of the epididymis. (wikidoc.org)
  • Mininberg DT, Schlossberg S. The role of the epididymis in testicular descent. (springermedizin.de)
  • During ejaculation , sperm flow from the lower portion of the epididymis (which functions as a storage reservoir). (wikidoc.org)
  • The epididymal head overhangs the upper pole of the testis, receives the seminal fluid from the ducts of the testis (which pierce the upper portion of the mediastinum), then allows the passage of the sperm into the distal portion of the epididymis. (medscape.com)
  • In the caput (head) region these cells have long stereocilia that are tuft like extensions that project into the lumen. (wikipedia.org)
  • Androgen binding protein (ABP) was measured during postnatal development in normal and irradiated rats to determine whether development of a blood-testis barrier and formation of a continuous lumen from testis to epididymis is correlated with entry of ABP into the caput epididymis. (nih.gov)
  • Indeed, ABP is not detectable in the epididymis until 18-20 days of age (1.0 pmol/mg) at which time blood-testis barrier formation and lumen development is complete. (nih.gov)
  • In the SCE testis neither blood-testis barrier development nor lumen formation are complete until 30 days of age, at which time ABP is first detectable in epididymis of the irradiated rat. (nih.gov)
  • These findings suggest that entry of ABP into caput epididymis is an index of blood-testis barrier formation and lumen development. (nih.gov)
  • Morphological and enzymatic study of membrane-bound vesicles from the lumen of the rat epididymis. (springer.com)
  • Changes were seen later in the epididymis at 24 to 48 hours, and included an increase in the size of the lumen of the duct in the initial segment and caput regions with oedema of the interstitial space and a concurrent increase in weight of the epididymis. (bl.uk)
  • GPX5 is found in the caput & cauda epididymis lumen in 3 locations: as a soluble protein in the caput epididymal fluid, weakly bound to caput sperm membranes, or associated to lipid-containing structures causing a protective effect against proteolysis. (antibodies-online.com)
  • The alveoli and ducts were lined with tall columnar epithelium in the caput epididymis of calves and it was pseudostratified columnar with branched stereocilia in corpus epididymis of calves and adult animals. (eurekamag.com)
  • STUDY FINDING: We identified the molecular signature driving functions of the caput, corpus and cauda epithelium, and determined how these differ to establish the regional differentiation of the organ. (luriechildrens.org)
  • WIDER IMPLICATIONS OF THE FINDINGS: Our data provide a molecular characterization that will facilitate advances in understanding human epididymis epithelium biology in health and disease. (luriechildrens.org)
  • The epididymis is covered by a two layered pseudostratified epithelium . (wikipedia.org)
  • Erratum to "HNF1 regulates critical processes in the human epididymis epithelium" [Mol. (nih.gov)
  • HNF1 regulates critical processes in the human epididymis epithelium. (nih.gov)
  • The epithelium was pseudostratified, and changed to tall columnar and low columnar with cilia in the catput, corpus and cauda epididymis respectively. (pulsus.com)
  • In our previous studies, we showed that a finasteride-induced DHT deficiency may cause changes in the morphology of the seminiferous epithelium without any morphological alteration of the epididymis. (degruyter.com)
  • In this study, we demonstrated the constitutive immunoexpression of inducible nitric oxide synthase (iNOS) in the testis and epididymis of Wistar rats treated with finasteride for 28 days (the duration of two cycles of the seminiferous epithelium) and 56 days (the duration of one spermatogenesis). (degruyter.com)
  • Previously our laboratory reported that in the mouse, in addition to its expression in the testis, Spam1 is synthesized in the epididymis where it is found in membranous vesicles in the principal cells of the epithelium in all three regions. (nih.gov)
  • Na$\sp+$,K$\sp+$-ATPase enzyme activity and its regulation was determined in the ductuli efferentes and the initial segment of the epididymis of the rat. (illinois.edu)
  • We showed in the immunohistochemistry study the expression of FSH-R in rat and human ductuli efferentes and the caput, corpus, and cauda epididymis, moreover, by Western blot analysis in the caput and cauda epididymis of rat. (hindawi.com)
  • From this the sperm drains through a few, narrow ducts, the ductuli efferentes, into the epididymis, where sperm mature and are stored. (thefreedictionary.com)
  • It was concluded that androgens maintain the basic activity of Na$\sp+$,K$\sp+$-ATPase in the ductuli efferentes and the head of the epididymis and this action is possibly mediated by androgen receptors. (illinois.edu)
  • Sperm quality in the Caput, corpus, and cauda regions of the epididymis of healthy and sexually mature Landrace boars was studied. (eurekamag.com)
  • From proximal to distal, the epididymis is divided into caput, corpus, and cauda regions. (biomedcentral.com)
  • Among these miRNAs , miR-890 , miR-892a , miR-892b , miR-891a, miR-891b belonging to the same epididymis-enriched cluster located on the X chromosome, are significantly more expressed in the corpus and cauda regions than in the caput. (mirbase.org)
  • B7-H3 protein was predominantly detected on the membrane and in the cytoplasm of the principal cells in the epididymis. (biomedcentral.com)
  • Immunohistochemical analysis of uterus tissue from 3 and 4 week old homozygous females and epididymis from homozygous males also shows diminished Ash1l gene product expression (protein). (jax.org)
  • It was identified as an epididymis-specific glutathione peroxidase by cloning and analyzing its cDNA.The 23kDa protein dose not contain selenocysteine in its catalytic center, resulting in the very low catalytic activity. (nii.ac.jp)
  • The mRNA of the 23kDa protein is detected only in the proximal caput epididymis. (nii.ac.jp)
  • Publications] Okamura,N.: 'Cloning of cDNA encloding a 135kDa protein secreted from povcine corpus epedidymis and its idenbtification as an epididymis-specific α-mannosidase. (nii.ac.jp)
  • Passage through the epididymis induces many changes to the newly formed sperm, including alterations in net surface charge, membrane protein composition, immunoreactivity, phospholipid and fatty acid content, and adenylate cyclase activity. (health.am)
  • We demonstrate that a testicular germ-cell-secreted epidermal growth factor-like protein, neural epidermal growth factor-like-like 2 (NELL2), specifically binds to an orphan receptor tyrosine kinase, c-ros oncogene 1 (ROS1), and mediates the differentiation of the initial segment (IS) of the caput epididymis. (bvsalud.org)
  • A seven-transmembrane (7TM) domain protein, human epididymis-specific protein 6 (HE6/GPR64) has been found to be highly expressed within the proximal epididymis ( 34 ) and recently within the efferent ductules ( 32 ). (asm.org)
  • SPAM1 (PH-20) protein and mRNA expression in the epididymides of humans and macaques: utilizing laser microdissection/RT-PCR. (nih.gov)
  • The absence of IDO also increased the tryptophan content of the caput epididymis and generated a parallel increase in caput epididymal protein content as a consequence of deficient proteasomal activity. (uni-regensburg.de)
  • Of previously predicted mRNA targets of the miR-888 cluster, we found that Spag8 (sperm associated antigen 8) mRNA expression encoding for a human sperm membrane protein (hSMP-1) was significantly and negatively correlated with the expression of miR-892a along the human epididymis (Tables 2 and 3, Fig. S3). (mirbase.org)
  • In reptiles, there is an additional canal between the testis and the head of the epididymis and which receives the various efferent ducts. (wikipedia.org)
  • while the posterior tubules are represented by the ductuli aberrantes , and by the paradidymis , which is sometimes found in front of the spermatic cord above the head of the epididymis. (wikipedia.org)
  • Androgenic regulation of the structure and functions of the epididymis. (nih.gov)
  • The vasal units in E2 subjected to URYX followed by normal saline showed no histological abnormalities of the epididymis and testis. (biomedsearch.com)
  • Resistant murine strains demonstrate a decreased cadmium concentration in the testis and also in the epididymis and seminal vesicle. (aspetjournals.org)
  • and also in the epididymis and seminal vesicle (King et al. (aspetjournals.org)
  • HAMILTON (1975) reported that epididymis is a dynamic structure of the seminal pathway, and its complex morphophysiology does not agree with the concept that epididymis would have merely a passive influence on sperm physiology. (scielo.cl)
  • Consists of dilation of an efferent ductule in the region of rete testis or caput epididymis. (auanet.org)
  • This study was designed to understand the morphology and localization of AQPs in ram efferent ducts (ED) and epididymis. (ovid.com)
  • Sperm aspirated from the efferent ducts and caput epididymis can be morphologically similar to sperm from normospermic men except for the presence of cytoplasmic droplets. (maleinfertility.org)
  • Therefore, in obstruction, better quality sperm can be found proximally in the efferent ducts or caput epididymis, and the distal epididymis is the site of sperm degeneration. (maleinfertility.org)
  • Reduced sperm content is generally caused by reduced testicular spermatogenesis but can also be due to an obstructive lesion in the efferent ducts preventing sperm from a normal-appearing testis from reaching the epididymis. (nih.gov)
  • The histology and histochemistry of caput and corpus epididymis of each of 6 non-descript buffalo calves, six months old and adult buffalo was studied. (eurekamag.com)
  • Epididymal sperm-coating proteins may exert their effects on the male gamete already in the epididymis or become functional in the female tract. (scielo.cl)
  • Some of the proteins produced by the epididymis, called sperm decapacitating factors, may associate to the cell surface and prevent premature sperm activation. (scielo.cl)
  • The proteins secreted from restricted regions in epididymis seem to be very important for sperm to acquire motility and fertilizing capacity. (nii.ac.jp)
  • Bioinformatic tools were then utilized to identify differentially expressed genes (DEGs) between tissues and cells from the caput, corpus and cauda. (luriechildrens.org)
  • In this study we analyzed cadmium transport into tissues with a vascular barrier, the testis, epididymis, and brain, in an attempt to characterize the mechanisms of strain resistance to cadmium-induced testicular toxicity. (aspetjournals.org)
  • These data exclude direct genomic effects of gestagens at the spermatogenic level but indicate that a male contraceptive based on gestagens might have some effects on other tissues, such as the epididymis, prostate and mammary gland. (labome.org)
  • All animals were sacrificed, and tissues (distal vas, injection site, proximal vas, cauda epididymis, caput epididymis, and testis) were harvested and examined for the presence of URYX. (biomedsearch.com)
  • In the presence of reproductive tract obstruction, continual sperm production by the testis occurs and ongoing resorption of dead and degenerated sperm in the distal epididymis is found. (maleinfertility.org)
  • TEX101 was shed from epididymal sperm during the sperm transfer from testis to epididymis. (nii.ac.jp)
  • Aqui se evaluaron los cambios morfologicos en la histoarquitectura en la toxicidad precoz testicular y cauda antes y despues del tratamiento con bloqueadores de receptores de angiotensina. (thefreedictionary.com)
  • Changes in the testis and epididymis were considered to have occurred as a consequence of the effect on the testicular vasculature. (bl.uk)
  • The epididymis, therefore, represents an alternative target organ for male contraception ( 5 ) and circumvents the potentially disadvantageous testicular steroidal regulation which is currently a favored approach ( 21 ). (asm.org)
  • Reverse transcription polymerase chain reaction assay indicated that α 1a -, α 1b -, and α 1d -adrenoceptor transcripts were present in both caput and cauda epididymis from adult rats. (bioone.org)
  • Prazosin (nonselective α 1 antagonist), 5-methyl urapidil (α 1A -selective), and BMY 7378 (α 1D -selective) displaced [ 3 H]prazosin binding curves in caput and cauda epididymis from 40- and 120-day-old rats. (bioone.org)
  • However, no ABP was detectable in the epididymis of either the control or the FSH-stimulated rats. (nih.gov)
  • We noted that a 56-day finasteride treatment mainly caused a decrease in the level of circulating DHT, as well as a statistically insignificant decrease in the level of T. The hormone deficiency also led to a change in the iNOS immnoexpression in the testis and epididymis of the finasteride-treated rats. (degruyter.com)
  • Sperm made in the testis go into the head ( caput ) of the epididymis, go through the body ( corpus ) and stop at the tail ( cauda ), where they are stored. (wikipedia.org)
  • When the sperm are ejaculated, they move through the tail of the epididymis. (wikipedia.org)
  • Located on the posterior border of the testis, it is composed of 3 parts, including the head (caput), body (corpora), and tail (cauda). (medscape.com)
  • Anatomically, the epididymis is classically divided into 3 regions: caput or head, corpus or body, and cauda or tail. (health.am)
  • Epididymis consists of the head (caput), the body (corpus), and the tail (cauda). (umassmed.edu)
  • In contrast, sperm from the tail of an obstructed epididymis are in advanced stages of degeneration and necrosis. (maleinfertility.org)
  • The epididymis is the part of the human male reproductive system . (wikipedia.org)
  • In the male reproductive tract, the caput epididymis, the structure where sperm matures, releases tiny vesicles packed with microRNA that can fuse with sperm to change its cargo delivered to the egg. (eurekalert.org)
  • The epididymis has been regarded as a highly specialized ductal system that forms an integral part of the male reproductive system. (pulsus.com)
  • In the offspring of diabetic dams the weight of reproductive organs at 40, 60 and 90 days-old was lower, as well as sperm reserves and sperm transit time through the epididymis. (biomedcentral.com)
  • In reproductive tract obstruction, improved motility is seen in sperm retrieved from the caput epididymis compared to the cauda. (maleinfertility.org)
  • It is specifically expressed in the epididymis in the mammalian male reproductive tract, and is androgen-regulated. (antibodies-online.com)
  • The number of macrophages progressively decreases toward the proximal epididymis and testis, while the quantity of motile sperm gradually increases. (scielo.br)
  • We found that Fut1 mRNA and Fut4 mRNA were upregulated, while Fut2 mRNA and Fut9 mRNA were downregulated by androgen in the caput epididymis. (mdpi.com)
  • We identified the androgen receptor binding sites (ARBSs) of Fut2 , Fut4 and Fut9 in the caput epididymis. (mdpi.com)
  • We demonstrated that 23 mouse caput epididymal beta-defensins were differentially regulated by androgen/androgen receptor. (biomedcentral.com)
  • Mammalian sperm acquire the capacity for motility and fertility during transit through epididymis. (nii.ac.jp)
  • The transit time of sperm through the fine tubules of the epididymis is thought to be 10-15 days in humans. (health.am)
  • However the decrease in sperm reserves in epididymal cauda and the acceleration in sperm transit time in this portion of epididymis may lead to an impairment of sperm quality and fertility potential in these animals. (biomedcentral.com)
  • It has long been thought that sperm exiting the testis lack maturity, motility, and fertilizing capability and that transit through the epididymis is essential to the acquisition of these features. (maleinfertility.org)
  • Publications] Okamura,N.: 'Direct evidences for the elevated synthesis and secretion of procathepsin L in the distal caput epididymis of boar. (nii.ac.jp)
  • Given the large number of sperm present in the epididymis at any one time (several billion in the case of the bull, boar and ram), phagocytosis of even 0.1% would be readily detectable on tissue sections examined in the microscope, especially since sperm heads are difficult to digest intracellularly. (biologists.org)
  • The epididymis is a storage organ of sperm and is related to male fertility. (biomedcentral.com)
  • The ducts of the cauda epididymis seemed to be larger than those of both the catput and corpus epididymis. (pulsus.com)
  • These tubules empty their contents into a network of anastomosing ducts, which ultimately empties into the epididymis. (medscape.com)
  • Because sperm are initially non-motile as they leave the seminiferous tubules , large volumes of fluid are secreted to propel them to the epididymis. (wikipedia.org)
  • This absorption creates a fluid current that moves the immobile sperm from the seminiferous tubules to the epididymis. (wikipedia.org)
  • Sperm entering the caput epididymis are incomplete-they lack the ability to swim forward (motility) and to fertilize an egg. (wikipedia.org)
  • The epididymis secretes an intraluminal environment that suppresses sperm motility until ejaculation. (wikipedia.org)
  • Epididymis" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)
  • The stereocilia of the epididymis are long cytoplasmic projections that have an actin filament backbone. (wikipedia.org)
  • [4] The stereocilia in the epididymis are non-motile. (wikipedia.org)
  • The epididymis is one of only two regions of the body to have stereocilia (the inner ear being the other. (wikidoc.org)
  • However, it was differentially immunolocalized in bulbourethral glands and stereocilia of epididymis. (upm.es)
  • Their distribution and roles in caput and cauda epididymal sperm cells are discussed. (bioscience.org)
  • However, the characteristics of its expression in different regions of the epididymis remain unknown. (biomedcentral.com)
  • However, the levels of B7-H3 were different in the three regions of the epididymis. (biomedcentral.com)
  • Measurement of enzyme levels in the three distinct epididymal regions revealed that in any given sample, activity was higher in the caput than in the corpus or cauda. (unipg.it)
  • Although these three anatomical regions of the epididymis are easily identified in most adult male mammals [ 2 ], histological and ultrastructural segmentation of this organ varies among the different species of mammals [ 2 ]. (pulsus.com)
  • Our results show that both epididymis regions, caput and cauda, express leptin and OBR. (thefreedictionary.com)
  • The samples, collected from the anatomical regions of the epididymides, were fixed in Bouin's fluid, dehydrated and embedded in paraffin. (scielo.cl)
  • We extracted epididymis specimens from adult male C57BL/6 mice. (biomedcentral.com)
  • Surprisingly, the epididymides of the mutant mice also displayed an abnormal phenotype. (biologists.org)
  • Fluid movement in the epididymis is important for modulation of the luminal environment, in which sperm mature and reside. (ovid.com)