Hard or soft soluble containers used for the oral administration of medicine.
An envelope of loose gel surrounding a bacterial cell which is associated with the virulence of pathogenic bacteria. Some capsules have a well-defined border, whereas others form a slime layer that trails off into the medium. Most capsules consist of relatively simple polysaccharides but there are some bacteria whose capsules are made of polypeptides.
Non-invasive, endoscopic imaging by use of VIDEO CAPSULE ENDOSCOPES to perform examination of the gastrointestinal tract, especially the small bowel.
The sac enclosing a joint. It is composed of an outer fibrous articular capsule and an inner SYNOVIAL MEMBRANE.
The thin noncellular outer covering of the CRYSTALLINE LENS composed mainly of COLLAGEN TYPE IV and GLYCOSAMINOGLYCANS. It is secreted by the embryonic anterior and posterior epithelium. The embryonic posterior epithelium later disappears.
A pill sized videocamera encased in a capsule. It is designed to be swallowed and subsequently traverse the gastrointestinal tract while transmitting diagnostic images along the way.
WHITE MATTER pathway, flanked by nuclear masses, consisting of both afferent and efferent fibers projecting between the WHITE MATTER and the BRAINSTEM. It consists of three distinct parts: an anterior limb, posterior limb, and genu.
An extracellular layer outside the cell wall of a fungus composed of polysaccharides. It may serve a protective role amongst others.
A double-walled epithelial capsule that is the bulbous closed proximal end of the kidney tubular system. It surrounds the cluster of convoluted capillaries of KIDNEY GLOMERULUS and is continuous with the convoluted PROXIMAL KIDNEY TUBULE.
In vivo method of screening investigative anticancer drugs and biologic response modifiers for individual cancer patients. Fresh tumor tissue is implanted under the kidney capsule of immunocompetent mice or rats; gross and histological assessments follow several days after tumor treatment in situ.
Polysaccharides found in bacteria and in capsules thereof.
Clouding or loss of transparency of the posterior lens capsule, usually following CATARACT extraction.
The posterior aspect of the casing that surrounds the natural CRYSTALLINE LENS.
A species of the fungus CRYPTOCOCCUS. Its teleomorph is Filobasidiella neoformans.
The making of a continuous circular tear in the anterior capsule during cataract surgery in order to allow expression or phacoemulsification of the nucleus of the lens. (Dorland, 28th ed)
A transparent, biconvex structure of the EYE, enclosed in a capsule and situated behind the IRIS and in front of the vitreous humor (VITREOUS BODY). It is slightly overlapped at its margin by the ciliary processes. Adaptation by the CILIARY BODY is crucial for OCULAR ACCOMMODATION.
The anterior aspect of the casing that surrounds the natural CRYSTALLINE LENS.
Instruments for the visual examination of the interior of the gastrointestinal tract.
The degree of pathogenicity within a group or species of microorganisms or viruses as indicated by case fatality rates and/or the ability of the organism to invade the tissues of the host. The pathogenic capacity of an organism is determined by its VIRULENCE FACTORS.
Chinese herbal or plant extracts which are used as drugs to treat diseases or promote general well-being. The concept does not include synthesized compounds manufactured in China.
Endoscopic examination, therapy or surgery of the gastrointestinal tract.
Pathological processes in any segment of the INTESTINE from DUODENUM to RECTUM.
Bleeding in any segment of the GASTROINTESTINAL TRACT from ESOPHAGUS to RECTUM.
Prolonged shortening of the muscle or other soft tissue around a joint, preventing movement of the joint.
A procedure for removal of the crystalline lens in cataract surgery in which an anterior capsulectomy is performed by means of a needle inserted through a small incision at the temporal limbus, allowing the lens contents to fall through the dilated pupil into the anterior chamber where they are broken up by the use of ultrasound and aspirated out of the eye through the incision. (Cline, et al., Dictionary of Visual Science, 4th ed & In Focus 1993;1(1):1)
The portion of the GASTROINTESTINAL TRACT between the PYLORUS of the STOMACH and the ILEOCECAL VALVE of the LARGE INTESTINE. It is divisible into three portions: the DUODENUM, the JEJUNUM, and the ILEUM.
Tablets coated with material that delays release of the medication until after they leave the stomach. (Dorland, 28th ed)
Partial or complete opacity on or in the lens or capsule of one or both eyes, impairing vision or causing blindness. The many kinds of cataract are classified by their morphology (size, shape, location) or etiology (cause and time of occurrence). (Dorland, 27th ed)
Infection with a fungus of the species CRYPTOCOCCUS NEOFORMANS.
Surgical procedure to relax the JOINT CAPSULE tissues in a joint that has a reduced range of motion due to CONTRACTURE or TISSUE ADHESIONS or joint deformities.
Dosage forms of a drug that act over a period of time by controlled-release processes or technology.
The removal of a cataractous CRYSTALLINE LENS from the eye.
Solid dosage forms, of varying weight, size, and shape, which may be molded or compressed, and which contain a medicinal substance in pure or diluted form. (Dorland, 28th ed)
Chronic inflammation and granuloma formation around irritating foreign bodies.
Artificial implanted lenses.
A gram-positive organism found in the upper respiratory tract, inflammatory exudates, and various body fluids of normal and/or diseased humans and, rarely, domestic animals.
Devices implanted to control intraocular pressure by allowing aqueous fluid to drain from the anterior chamber. (Hoffman, Pocket Glossary of Ophthalmologic Terminology, 1989)
An enzyme that catalyzes the oxidation of UDPglucose to UDPglucuronate in the presence of NAD+. EC
Proteins found in any species of bacterium.
Chemistry dealing with the composition and preparation of agents having PHARMACOLOGIC ACTIONS or diagnostic use.
A peptide that is a homopolymer of glutamic acid.
The giving of drugs, chemicals, or other substances by mouth.
A species of bacteria that causes ANTHRAX in humans and animals.
Insertion of an artificial lens to replace the natural CRYSTALLINE LENS after CATARACT EXTRACTION or to supplement the natural lens which is left in place.
Passage of food (sometimes in the form of a test meal) through the gastrointestinal tract as measured in minutes or hours. The rate of passage through the intestine is an indicator of small bowel function.
The preparation, mixing, and assembling of a drug. (From Remington, The Science and Practice of Pharmacy, 19th ed, p1814)
The transference of pancreatic islets within an individual, between individuals of the same species, or between individuals of different species.
Polymers of silicone that are formed by crosslinking and treatment with amorphous silica to increase strength. They have properties similar to vulcanized natural rubber, in that they stretch under tension, retract rapidly, and fully recover to their original dimensions upon release. They are used in the encapsulation of surgical membranes and implants.
Process of determining and distinguishing species of bacteria or viruses based on antigens they share.
A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.
A mitosporic Tremellales fungal genus whose species usually have a capsule and do not form pseudomycellium. Teleomorphs include Filobasidiella and Fidobasidium.
The extent to which the active ingredient of a drug dosage form becomes available at the site of drug action or in a biological medium believed to reflect accessibility to a site of action.
Microscopy using an electron beam, instead of light, to visualize the sample, thereby allowing much greater magnification. The interactions of ELECTRONS with specimens are used to provide information about the fine structure of that specimen. In TRANSMISSION ELECTRON MICROSCOPY the reactions of the electrons that are transmitted through the specimen are imaged. In SCANNING ELECTRON MICROSCOPY an electron beam falls at a non-normal angle on the specimen and the image is derived from the reactions occurring above the plane of the specimen.
A species of gram-negative, aerobic BACTERIA. It is a commensal and pathogen only of humans, and can be carried asymptomatically in the NASOPHARYNX. When found in cerebrospinal fluid it is the causative agent of cerebrospinal meningitis (MENINGITIS, MENINGOCOCCAL). It is also found in venereal discharges and blood. There are at least 13 serogroups based on antigenic differences in the capsular polysaccharides; the ones causing most meningitis infections being A, B, C, Y, and W-135. Each serogroup can be further classified by serotype, serosubtype, and immunotype.
Enzymes that catalyze the transfer of glycosyl groups to an acceptor. Most often another carbohydrate molecule acts as an acceptor, but inorganic phosphate can also act as an acceptor, such as in the case of PHOSPHORYLASES. Some of the enzymes in this group also catalyze hydrolysis, which can be regarded as transfer of a glycosyl group from the donor to water. Subclasses include the HEXOSYLTRANSFERASES; PENTOSYLTRANSFERASES; SIALYLTRANSFERASES; and those transferring other glycosyl groups. EC 2.4.
The functional hereditary units of BACTERIA.
A broad family of synthetic organosiloxane polymers containing a repeating silicon-oxygen backbone with organic side groups attached via carbon-silicon bonds. Depending on their structure, they are classified as liquids, gels, and elastomers. (From Merck Index, 12th ed)
Pathological development in the JEJUNUM region of the SMALL INTESTINE.
Endoscopy of the small intestines accomplished while advancing the endoscope into the intestines from the stomach by alternating the inflation of two balloons, one on an innertube of the endoscope and the other on an overtube.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
The engulfing and degradation of microorganisms; other cells that are dead, dying, or pathogenic; and foreign particles by phagocytic cells (PHAGOCYTES).
Those components of an organism that determine its capacity to cause disease but are not required for its viability per se. Two classes have been characterized: TOXINS, BIOLOGICAL and surface adhesion molecules that effect the ability of the microorganism to invade and colonize a host. (From Davis et al., Microbiology, 4th ed. p486)
Term used to designate tetrahydroxy aldehydic acids obtained by oxidation of hexose sugars, i.e. glucuronic acid, galacturonic acid, etc. Historically, the name hexuronic acid was originally given to ascorbic acid.
Completed forms of the pharmaceutical preparation in which prescribed doses of medication are included. They are designed to resist action by gastric fluids, prevent vomiting and nausea, reduce or alleviate the undesirable taste and smells associated with oral administration, achieve a high concentration of drug at target site, or produce a delayed or long-acting drug effect.
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.
Salts of alginic acid that are extracted from marine kelp and used to make dental impressions and as absorbent material for surgical dressings.
The natural bactericidal property of BLOOD due to normally occurring antibacterial substances such as beta lysin, leukin, etc. This activity needs to be distinguished from the bactericidal activity contained in a patient's serum as a result of antimicrobial therapy, which is measured by a SERUM BACTERICIDAL TEST.
Substances elaborated by bacteria that have antigenic activity.
Elements of limited time intervals, contributing to particular results or situations.
A physical property showing different values in relation to the direction in or along which the measurement is made. The physical property may be with regard to thermal or electric conductivity or light refraction. In crystallography, it describes crystals whose index of refraction varies with the direction of the incident light. It is also called acolotropy and colotropy. The opposite of anisotropy is isotropy wherein the same values characterize the object when measured along axes in all directions.
An acute infection caused by the spore-forming bacteria BACILLUS ANTHRACIS. It commonly affects hoofed animals such as sheep and goats. Infection in humans often involves the skin (cutaneous anthrax), the lungs (inhalation anthrax), or the gastrointestinal tract. Anthrax is not contagious and can be treated with antibiotics.
Microscopy in which the object is examined directly by an electron beam scanning the specimen point-by-point. The image is constructed by detecting the products of specimen interactions that are projected above the plane of the sample, such as backscattered electrons. Although SCANNING TRANSMISSION ELECTRON MICROSCOPY also scans the specimen point by point with the electron beam, the image is constructed by detecting the electrons, or their interaction products that are transmitted through the sample plane, so that is a form of TRANSMISSION ELECTRON MICROSCOPY.
Tissue that supports and binds other tissues. It consists of CONNECTIVE TISSUE CELLS embedded in a large amount of EXTRACELLULAR MATRIX.
A darkly stained mat-like EXTRACELLULAR MATRIX (ECM) that separates cell layers, such as EPITHELIUM from ENDOTHELIUM or a layer of CONNECTIVE TISSUE. The ECM layer that supports an overlying EPITHELIUM or ENDOTHELIUM is called basal lamina. Basement membrane (BM) can be formed by the fusion of either two adjacent basal laminae or a basal lamina with an adjacent reticular lamina of connective tissue. BM, composed mainly of TYPE IV COLLAGEN; glycoprotein LAMININ; and PROTEOGLYCAN, provides barriers as well as channels between interacting cell layers.
Any of the processes by which cytoplasmic or intercellular factors influence the differential control of gene action in bacteria.
Studies comparing two or more treatments or interventions in which the subjects or patients, upon completion of the course of one treatment, are switched to another. In the case of two treatments, A and B, half the subjects are randomly allocated to receive these in the order A, B and half to receive them in the order B, A. A criticism of this design is that effects of the first treatment may carry over into the period when the second is given. (Last, A Dictionary of Epidemiology, 2d ed)
A group of naturally occurring N-and O-acyl derivatives of the deoxyamino sugar neuraminic acid. They are ubiquitously distributed in many tissues.
The lipopolysaccharide-protein somatic antigens, usually from gram-negative bacteria, important in the serological classification of enteric bacilli. The O-specific chains determine the specificity of the O antigens of a given serotype. O antigens are the immunodominant part of the lipopolysaccharide molecule in the intact bacterial cell. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)
Usually inert substances added to a prescription in order to provide suitable consistency to the dosage form. These include binders, matrix, base or diluent in pills, tablets, creams, salves, etc.
A sugar acid formed by the oxidation of the C-6 carbon of GLUCOSE. In addition to being a key intermediate metabolite of the uronic acid pathway, glucuronic acid also plays a role in the detoxification of certain drugs and toxins by conjugating with them to form GLUCURONIDES.
Transmission of the readings of instruments to a remote location by means of wires, radio waves, or other means. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Physicochemical property of fimbriated (FIMBRIAE, BACTERIAL) and non-fimbriated bacteria of attaching to cells, tissue, and nonbiological surfaces. It is a factor in bacterial colonization and pathogenicity.
Shiny, flexible bands of fibrous tissue connecting together articular extremities of bones. They are pliant, tough, and inextensile.
Products in capsule, tablet or liquid form that provide dietary ingredients, and that are intended to be taken by mouth to increase the intake of nutrients. Dietary supplements can include macronutrients, such as proteins, carbohydrates, and fats; and/or MICRONUTRIENTS, such as VITAMINS; MINERALS; and PHYTOCHEMICALS.
A necessary enzyme in the metabolism of galactose. It reversibly catalyzes the conversion of UDPglucose to UDPgalactose. NAD+ is an essential component for enzymatic activity. EC
A natural high-viscosity mucopolysaccharide with alternating beta (1-3) glucuronide and beta (1-4) glucosaminidic bonds. It is found in the UMBILICAL CORD, in VITREOUS BODY and in SYNOVIAL FLUID. A high urinary level is found in PROGERIA.
The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.
A species of gram-positive, coccoid bacteria isolated from skin lesions, blood, inflammatory exudates, and the upper respiratory tract of humans. It is a group A hemolytic Streptococcus that can cause SCARLET FEVER and RHEUMATIC FEVER.
Acquired degenerative dilation or expansion (ectasia) of normal BLOOD VESSELS, often associated with aging. They are isolated, tortuous, thin-walled vessels and sources of bleeding. They occur most often in mucosal capillaries of the GASTROINTESTINAL TRACT leading to GASTROINTESTINAL HEMORRHAGE and ANEMIA.
Gram-negative, non-motile, capsulated, gas-producing rods found widely in nature and associated with urinary and respiratory infections in humans.
Use of plants or herbs to treat diseases or to alleviate pain.
Small containers or pellets of a solid drug implanted in the body to achieve sustained release of the drug.
An N-acyl derivative of neuraminic acid. N-acetylneuraminic acid occurs in many polysaccharides, glycoproteins, and glycolipids in animals and bacteria. (From Dorland, 28th ed, p1518)
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
A product formed from skin, white connective tissue, or bone COLLAGEN. It is used as a protein food adjuvant, plasma substitute, hemostatic, suspending agent in pharmaceutical preparations, and in the manufacturing of capsules and suppositories.
Polymerized methyl methacrylate monomers which are used as sheets, moulding, extrusion powders, surface coating resins, emulsion polymers, fibers, inks, and films (From International Labor Organization, 1983). This material is also used in tooth implants, bone cements, and hard corneal contact lenses.
Cells that line the inner and outer surfaces of the body by forming cellular layers (EPITHELIUM) or masses. Epithelial cells lining the SKIN; the MOUTH; the NOSE; and the ANAL CANAL derive from ectoderm; those lining the RESPIRATORY SYSTEM and the DIGESTIVE SYSTEM derive from endoderm; others (CARDIOVASCULAR SYSTEM and LYMPHATIC SYSTEM) derive from mesoderm. Epithelial cells can be classified mainly by cell shape and function into squamous, glandular and transitional epithelial cells.
Methylester of cellulose. Methylcellulose is used as an emulsifying and suspending agent in cosmetics, pharmaceutics and the chemical industry. It is used therapeutically as a bulk laxative.
A class of nerve fibers as defined by their structure, specifically the nerve sheath arrangement. The AXONS of the myelinated nerve fibers are completely encased in a MYELIN SHEATH. They are fibers of relatively large and varied diameters. Their NEURAL CONDUCTION rates are faster than those of the unmyelinated nerve fibers (NERVE FIBERS, UNMYELINATED). Myelinated nerve fibers are present in somatic and autonomic nerves.
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria normally found in the flora of the mouth and respiratory tract of animals and birds. It causes shipping fever (see PASTEURELLOSIS, PNEUMONIC); HEMORRHAGIC BACTEREMIA; and intestinal disease in animals. In humans, disease usually arises from a wound infection following a bite or scratch from domesticated animals.
The outermost layer of a cell in most PLANTS; BACTERIA; FUNGI; and ALGAE. The cell wall is usually a rigid structure that lies external to the CELL MEMBRANE, and provides a protective barrier against physical or chemical agents.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.
Either of a pair of compound bones forming the lateral (left and right) surfaces and base of the skull which contains the organs of hearing. It is a large bone formed by the fusion of parts: the squamous (the flattened anterior-superior part), the tympanic (the curved anterior-inferior part), the mastoid (the irregular posterior portion), and the petrous (the part at the base of the skull).
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
The use of diffusion ANISOTROPY data from diffusion magnetic resonance imaging results to construct images based on the direction of the faster diffusing molecules.
A diagnostic technique that incorporates the measurement of molecular diffusion (such as water or metabolites) for tissue assessment by MRI. The degree of molecular movement can be measured by changes of apparent diffusion coefficient (ADC) with time, as reflected by tissue microstructure. Diffusion MRI has been used to study BRAIN ISCHEMIA and tumor response to treatment.
Substances made up of an aggregation of small particles, as that obtained by grinding or trituration of a solid drug. In pharmacy it is a form in which substances are administered. (From Dorland, 28th ed)
The motion of fluids, especially noncompressible liquids, under the influence of internal and external forces.
A polypeptide substance comprising about one third of the total protein in mammalian organisms. It is the main constituent of SKIN; CONNECTIVE TISSUE; and the organic substance of bones (BONE AND BONES) and teeth (TOOTH).
Transplantation of tissue typical of one area to a different recipient site. The tissue may be autologous, heterologous, or homologous.
Agents that are used to stimulate evacuation of the bowels.
Mutagenesis where the mutation is caused by the introduction of foreign DNA sequences into a gene or extragenic sequence. This may occur spontaneously in vivo or be experimentally induced in vivo or in vitro. Proviral DNA insertions into or adjacent to a cellular proto-oncogene can interrupt GENETIC TRANSLATION of the coding sequences or interfere with recognition of regulatory elements and cause unregulated expression of the proto-oncogene resulting in tumor formation.
Colloids with liquid continuous phase and solid dispersed phase; the term is used loosely also for solid-in-gas (AEROSOLS) and other colloidal systems; water-insoluble drugs may be given as suspensions.

Cephalosporin and aminoglycoside concentrations in peritoneal capsular fluid in rabbits. (1/735)

To study the penetration of antibiotics into peritoneal tissue fluid, a subcutaneous tissue capsule model was modified by implanting multiple, perforated spherical capsules in the peritoneal cavity of rabbits. Capsules became vascularized, encased in connective tissue, and filled with fluid having a mean protein concentration of 3.6 g/100 ml. Capsular fluid was obtained by percutaneous needle aspiration and assayed for antibiotic by the disk plate bioassay technique. Cephalosporins were administered intramuscularly at a dose of 30 mg/kg. Mean peak concentrations of cephaloridine and cefazolin were significantly higher than cephalothin and cephapirin in capsular fluids, but the percent penetration (ratio of capsular mean peak to serum mean peak) ranged from 8.7 to 16.9% and was not significantly different among the cephalosporins. At 24 h the capsular concentration of cefazolin was significantly greater than for the other cephalosporins (P < 0.001). Lower rabbit serum protein binding observed at high in vivo concentrations may have enabled cefazolin to penetrate capsular fluid, but in vitro protein binding studies did not confirm a decrease in serum protein binding at high concentrations within the clinical range. Kanamycin and amikacin showed comparable capsular fluid peak concentrations as did gentamicin and tobramycin. The percent penetration ranged from 15.2 to 34.5% for the aminoglycosides. The only statistical difference was that amikacin penetration was significantly higher than that for tobramycin. Mean capsular concentrations of amikacin, cefazolin, and cephaloridine compared most favorably with the minimum inhibitory concentration of gram-negative bacilli at the dosages used in this study.  (+info)

A cortisol suppression dose-response comparison of budesonide in controlled ileal release capsules with prednisolone. (2/735)

AIM: To assess the systemic effect of oral budesonide, given as Entocort controlled ileal release capsules, over a dose range of 3-15 mg/day, compared with that of a moderate dose (20 mg/day) of prednisolone. METHODS: Twenty four healthy subjects were given 3, 9 or 15 mg budesonide or 20 mg prednisolone once daily, or 4.5 mg budesonide b.d., or placebo for 5 days in a randomized, double-blind crossover study. The area under the curve (AUC) of plasma cortisol concentration and the amount of cortisol excreted in the urine were monitored. RESULTS: Both plasma and urine cortisol suppression showed a dose-response for the daily doses of budesonide. Prednisolone, 20 mg, suppressed plasma cortisol (AUC) statistically significantly more than 15 mg budesonide (P = 0.014), and 3 mg budesonide statistically significantly more than placebo (P = 0.010). No difference in AUC was detected between 9 mg and 4.5 mg budesonide b.d. Similar results for budesonide vs. placebo were obtained from urine cortisol excretion data. However, prednisolone affected urine cortisol less than it affected plasma cortisol. CONCLUSION: After 5 days of administration, budesonide controlled ileal release capsules, in both clinical (9 mg/day) and high doses (15 mg/day), affected plasma cortisol less than a moderate (20 mg/day) dose of prednisolone.  (+info)

Breast milk immune factors in Bangladeshi women supplemented postpartum with retinol or beta-carotene. (3/735)

BACKGROUND: Vitamin A supplementation of mothers postpartum may improve infant health, not only by increasing vitamin A delivery to the infant through breast milk but also by increasing delivery of milk immune factors. Our hypothesis was that postpartum supplementation with vitamin A increases milk concentrations of certain soluble immune factors. DESIGN: In a double-blind trial conducted in Matlab, Bangladesh, women at 1-3 wk postpartum were randomly assigned to receive until 9 mo postpartum 1) a single dose of 60 mg retinol as retinyl palmitate followed by daily placebos (n = 69), 2) daily doses of 7.6 mg beta-carotene (n = 72), or 3) daily placebos (n = 71). Milk samples collected at baseline and 3 mo postpartum were analyzed by enzyme-linked immunosorbent assay for secretory immunoglobulin A, lactoferrin, lysozyme, and interleukin 8; by HPLC for total retinol; and by atomic absorption spectroscopy for sodium and potassium. RESULTS: After mammary epithelial permeability (defined as an elevated Na:K) and baseline immune factor concentrations were controlled for, there were no significant treatment effects on immune factors at 3 mo. Increased mammary permeability was common (25% of women at baseline and 12% at 3 mo) and was associated with higher concentrations of milk immune factors. Low body vitamin A stores at baseline, as assessed by the modified-relative-dose-response test, were associated with a higher Na:K, but neither retinol nor beta-carotene supplementation affected the prevalence of increased mammary permeability. CONCLUSIONS: Postpartum vitamin A supplementation does not increase milk concentrations of immune factors. The causes of increased mammary epithelial permeability in this population require further study.  (+info)

Continuous delivery of human and mouse erythropoietin in mice by genetically engineered polymer encapsulated myoblasts. (4/735)

The transplantation of polymer encapsulated myoblasts genetically engineered to secrete erythropoietin (Epo) may obviate the need for repeated parenteral administration of recombinant Epo as a treatment for chronic renal failure, cancer or AIDS-associated anemia. To explore this possibility, the human and mouse Epo cDNAs under the control of the housekeeping mouse PGK-1 promoter were transfected into mouse C2C12 myoblasts, which can be terminally differentiated upon exposure to low serum-containing media. Pools releasing 150 IU human Epo per 10(6) cells per day and 390 IU mouse Epo per 10(6) cells per day were selected. Polyether-sulfone (PES) capsules loaded with approximately 200,000 transfected myoblasts from these pools were implanted on the dorsal flank of DBA/2J, C3H and C57BL/6 mice. With human Epo secreting capsules, only a transient increase in the hematocrit occurred in DBA/2J mice, whereas no significant response was detected in C3H or C57BL/6 mice. On the contrary, all mice implanted with capsules releasing mouse Epo increased their hematocrit over 85% as early as 7 days after implantation and sustained these levels for at least 80 days. All retrieved implants released Epo and contained well preserved myoblasts. Moreover most capsules were surrounded by a neovascularization. Mice transplanted with nonencapsulated C2C12 cells releasing mouse Epo showed only a transitory elevation of their hematocrit reflecting the poor engraftment of injected myoblasts. These results indicate that polymer encapsulation of genetically engineered myoblasts is a promising approach for the long-term delivery of bioactive molecules, allowing the resolution of the shortcomings of free myoblast transfer.  (+info)

Targeted chemotherapy by intratumour injection of encapsulated cells engineered to produce CYP2B1, an ifosfamide activating cytochrome P450. (5/735)

The prognosis of pancreatic adenocarcinoma is poor and current treatment ineffective. A novel treatment strategy is described here using a mouse model system for pancreatic cancer. Cells that have been genetically modified to express the cytochrome P450 2B1 enzyme are encapsulated in cellulose sulphate and implanted into pre-established tumours derived from human pancreatic cells. Cytochrome P450 2B1 converts the chemotherapeutic agent ifosfamide to toxic metabolites. Administration of ifosfamide to tumour-bearing mice that were recipients of implanted encapsulated cells results in partial or even complete tumour ablation. These results suggest that in situ chemotherapy with genetically modified cells in an immunoprotected environment may prove useful for application in man.  (+info)

Comparison of antiplatelet activity of microencapsulated aspirin 162.5 Mg (Caspac XL), with enteric coated aspirin 75 mg and 150 mg in patients with atherosclerosis. (6/735)

AIMS: A new formulation, low dose microencapsulated aspirin, permits slow absorption of aspirin and presystemic acetylation of platelet cyclo-oxygenase within the portal circulation, potentially avoiding deleterious effects on gastric and systemic prostaglandin synthesis. The objective of this study was to determine whether the administration of microencapsulated aspirin was as effective as enteric coated (EC) aspirin as an inhibitor of platelet function in patients with atherosclerosis. METHODS: One hundred and four patients were enrolled and randomised after a run in period of at least 14 days on aspirin EC 75 mg (day 0), to receive either microencapsulated aspirin 162.5 mg (n=34), aspirin EC 150 mg (n=36) or continue on aspirin EC 75 mg (n=34) for 28 days. Serum thromboxane B2 and collagen-induced platelet aggregation and release of 5-hydroxytryptamine (EC50 values) were measured on days 0 and 28. Aggregation/release EC50s were then repeated in the presence of a large dose of aspirin added in vitro to determine the EC50 at the maximum level of platelet inhibition. RESULTS: Median thromboxane B2 levels were low after 14 days run-in therapy with aspirin EC 75 mg, but significant further reductions were seen on day 28 in patients randomised to microencapsulated aspirin 162.5 mg (P=0.0368) and aspirin EC 150 mg (P=0.0004) compared with those remaining on aspirin EC 75 mg. Median EC50 s on day 28 showed small but significant increases from baseline (day 0) in aggregation in patients randomised to microencapsulated aspirin 162.5 mg (0.62-0.85, P=0.0482) and in both aggregation and release in patients randomised to aspirin EC 150 mg (0.95-1.20, P=0.0002, 8.4-11.7, P<0. 0001, respectively) signifying enhanced antiplatelet activity. No changes were seen in patients continuing on aspirin EC 75 mg. Results following addition of high dose aspirin in vitro suggest that mechanisms other than thromboxane synthesis may be operative in the long term effects of microencapsulated aspirin 162.5 mg and aspirin EC 150 mg over aspirin EC 75 mg. CONCLUSIONS: The results show good inhibition of thromboxane B2 synthesis and subsequent platelet activity by all preparations of aspirin, although both microencapsulated aspirin 162.5 mg and aspirin EC 150 mg are slightly more effective than aspirin EC 75 mg. A randomised trial is now required to determine whether microencapsulated aspirin is associated with fewer gastric side-effects.  (+info)

Improvement of mouse beta-thalassemia upon erythropoietin delivery by encapsulated myoblasts. (7/735)

The goal of the present study was to analyze if sustained delivery of elevated doses of recombinant erythropoietin (Epo), by genetically modified and immunoprotected allogenic cells, was able to correct the chronic anemia, characteristic of a spontaneous mouse model of beta-thalassemia (Hbb thal 1). Mouse C2C12 myoblast cells were transfected with a plasmid containing the mouse Epo cDNA and a mutated dihydrofolate reductase (DHFR) gene for gene amplification upon administration of increasing doses of methotrexate. In order to immunoprotect the transplanted cells, the stably modified cells were loaded into polyethersulfone microporus hollow fibers which were implanted subcutaneously into Hbb thal 1 mice. An increase in hematocrit starting 2 weeks after implantation was associated with elevated blood levels of Epo and an improved red blood cell phenotype. The latter indicated an improvement of cell morphology and membrane defects, in particular a reduced amount of free alpha hemoglobin chain, the hallmark of globin chain imbalance in beta-thalassemia. A reduction of reticulocyte count contrasting with the increase in hematocrit was also observed suggesting an improved erythrocyte survival. We conclude that the phenotype can be durably improved in some beta-thalassemic mice upon in vivo delivery of recombinant Epo by polymer encapsulated cells. Sustained elevated delivery of recombinant Epo holds promise for the treatment of beta-thalassemia-associated chronic anemia.  (+info)

Stabilized plasmid-lipid particles: construction and characterization. (8/735)

A detergent dialysis procedure is described which allows encapsulation of plasmid DNA within a lipid envelope, where the resulting particle is stabilized in aqueous media by the presence of a poly(ethyleneglycol) (PEG) coating. These 'stabilized plasmid-lipid particles' (SPLP) exhibit an average size of 70 nm in diameter, contain one plasmid per particle and fully protect the encapsulated plasmid from digestion by serum nucleases and E. coli DNase I. Encapsulation is a sensitive function of cationic lipid content, with maximum entrapment observed at dioleoyldimethylammonium chloride (DODAC) contents of 5 to 10 mol%. The formulation process results in plasmid-trapping efficiencies of up to 70% and permits inclusion of 'fusigenic' lipids such as dioleoylphosphatidylethanolamine (DOPE). The in vitro transfection capabilities of SPLP are demonstrated to be strongly dependent on the length of the acyl chain contained in the ceramide group used to anchor the PEG polymer to the surface of the SPLP. Shorter acyl chain lengths result in a PEG coating which can dissociate from the SPLP surface, transforming the SPLP from a stable particle to a transfection-competent entity. It is suggested that SPLP may have utility as systemic gene delivery systems for gene therapy protocols.  (+info)

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All subjects received all tested treatments in a randomised, open label, 3-way cross over study. The treatments were:. Single dose of 240 mg faldaprevir in a form of two soft gelatin capsules was administered orally following an overnight or at least 10 hours (h) fast prior the drug administration (Reference treatment). Single dose of 240 mg faldaprevir in a form of two soft gelatin capsules was administered orally 30 minutes (min) after a standard high-fat, high-caloric meal was served. The meal had to be completely consumed within 25 min or less.. Single dose of 240 mg faldaprevir in a form of two soft gelatin capsules was coadministered orally with 40 mg Omeprazole following an overnight or at least 10 hours (h) fast prior the drug administration following multiple dosing of 40 mg omeprazole once daily for 4 days prior the first dose of faldaprevir.. Drug administrations were separated by a washout period of at least 14 days. ...
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The aim of this study was to enhance the release rate of the hypoglycaemic agent glibenclamide from hard gelatin capsules through co-lyophilisation with sodium lauryl sulphate (SLS) and perform physical characterisation of the lyophilised product.. ...
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TY - JOUR. T1 - Physical characterization and drug release profiling for hard capsules prepared with hydroxypropylcellulose or polyethylene oxide. AU - Lee, Chien Yuan. AU - Chen, Gan Lin. AU - Sheu, Ming Thau. AU - Liu, Cheng Hsiung. PY - 2006/4. Y1 - 2006/4. N2 - In this study, hard capsule shells were made by a heat-melting method, which involved heating Polyethylene oxide (PEO, MW 200000) or hydroxypropyl cellulose (HPC, MW 80,000,100,000 and 370000) powder in a mold, followed by inserting a suitable size of pestle in a mold to coat the melted shell materials (HPC or PEO) onto pestle with a certain force. The more satisfactory were prepared at the temperature higher than melting point of corresponding polymer. The water uptake and dissolution test of various capsule shells were evaluated in acidic or basic buffer with added inorganic salt including sodium chloride, potassium chloride, calcium chloride and aluminum chloride. Propranolol hydrochloride and theophylline were selected as the ...
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0058]The stability of the capsules and pirfenidone/excipient formulations provided herein is demonstrated in the results presented in FIG. 8. The 267 mg pirfenidone capsule formulation of FIG. 6 was stored for 18 months under three different storage conditions: 25° C. and 60% relative humidity, 30° C. and 65% relative humidity, and 40° C. and 75% relative humidity. FIG. 8 shows that the dissolution of the capsule and pirfenidone/excipient formulations at 25° C. and 60% relative humidity, 30° C. and 65% relative humidity did not appreciably change over the duration of the 18 month period. The dissolution of the capsule and pirfenidone/excipient formulations at 40° C. and 75% relative humidity did not appreciably change over the initial 12 month period. The dissolution analysis was performed according to the pharmacopoeial dissolution method specified in USP29 using Apparatus 2 (paddles) with water as a solvent and a specification of Q=70% of label claim in 30 minutes. Also shown in FIG. 8, ...
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Subjects will be hospitalized to the clinical unit on the evening of Day -1. All subjects will receive 1 x 0.5mg oral dose of dutasteride (Sequence A), in the morning; Subjects will remain in the clinical unit until completion of all assessments at 24 hours post-dose on Day 2 including collection of the 24 hour post-dose PK sample. Subjects will return to the unit for the remaining PK samples at 36, 48 and 72 hours. The subject will receive or 5 x 0.1mg oral dose of dutasteride (Sequence B) in similar fashion as that of Sequence A. The two treatment sequences will be separated by a minimum washout period of 28 days to ensure that dutasteride is effectively eliminated from the subject between dosing occasions ...
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OBJECTIVE:To investigate the effect of Duyiwei(lamiophlomis rotate) capsule on the expression of proliferating cell nuclear antigen(PCNA) in Wistar rats.METHODS:40 Wistar rats,half male half female,were randomly divided into 5 groups:model group,PTCA group,Duyiwei(Lamiophlomis rotate) capsule 0.50,1.25,2.50 g/kg,positive control group(salvia miltrorrhiza tablet 1.0 g/kg).Oral administration of drugs was performed in each group,continuously 5 days.Then all rats were treated by percutaneous transluminal coronary angioplasty(PTCA) for the establishment of carotid balloon injury model.Then drug treatment continued after PTCA for 28 days.Carotid artery segment underwent routine biopsy immunohistochemistry and PCNA expression determination.RESULTS:In the normal artery,these was low level or no expression of PCNA.In the arterial intima of the model groups,33.71%was PCNA-positivewith each dose of Duyiwei capsule group showing significant differences(P0.05).CONCLUSION:Duyiwei capsule significantly inhibited the
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Captopril is an ACE inhibitor that is used for the treatment of hypertension. The purpose of this study was to encapsulate the drug in different polymer having mucoadhesive property and thus combining the advantages of microparticulates with mucoadhesive drug delivery system. The microcapsules with a coat consisting of alginate and a mucoadhesive polymer such as sodium carboxymethylcellulose (SCMC), methylcellulose, Carbopol 934P and hydroxyl propylmethylceullulose (HPMC) E15V were prepared by ionotropic gelation technique, where gelation was achieved with oppositely charged counter ions to form microparticles. The prepared microcapsules were subjected for various evaluations. The resulting microparticles were discrete, large, spherical and free-flowing. Captopril release from these microcapsules was slow and extended over longer period of time. Drug release for some formulation was diffusion controlled and others exhibited anomalous behavior. The prepared microcapsules exhibited good mucoadhesive
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Absorption Following administration of a single 0.5-mg dose of a soft gelatin capsule, time to peak serum concentrations (Tmax) of dutasteride occurs within 2 to 3 hours. Absolute bioavailability in 5 healthy subjects is approximately 60% (range: 40% to 94%). When the drug is administered with food, the maximum serum concentrations were reduced by 10% to 15%. This reduction is of no clinical significance.. Distribution Pharmacokinetic data following single and repeat oral doses show that dutasteride has a large volume of distribution (300 to 500 L). Dutasteride is highly bound to plasma albumin (99.0%) and alpha-1 acid glycoprotein (96.6%).. In a trial of healthy subjects (n = 26) receiving dutasteride 0.5 mg/day for 12 months, semen dutasteride concentrations averaged 3.4 ng/mL (range: 0.4 to 14 ng/mL) at 12 months and, similar to serum, achieved steady-state concentrations at 6 months. On average, at 12 months 11.5% of serum dutasteride concentrations partitioned into semen.. Metabolism and ...
Absorption Following administration of a single 0.5-mg dose of a soft gelatin capsule, time to peak serum concentrations (Tmax) of dutasteride occurs within 2 to 3 hours. Absolute bioavailability in 5 healthy subjects is approximately 60% (range: 40% to 94%). When the drug is administered with food, the maximum serum concentrations were reduced by 10% to 15%. This reduction is of no clinical significance. Distribution Pharmacokinetic data following single and repeat oral doses show that dutasteride has a large volume of distribution (300 to 500 L). Dutasteride is highly bound to plasma albumin (99.0%) and alpha-1 acid glycoprotein (96.6%). In a trial of healthy subjects (n = 26) receiving dutasteride 0.5 mg/day for 12 months, semen dutasteride concentrations averaged 3.4 ng/mL (range: 0.4 to 14 ng/mL) at 12 months and, similar to serum, achieved steady-state concentrations at 6 months. On average, at 12 months 11.5% of serum dutasteride concentrations partitioned into semen. Metabolism and ...
This is one of the leading pharma companies of Algeria. More than a laboratory, it aims to be a real player in public health in Algeria. By placing more than 50 million sales units on the market annually, this supports health practitioners in their noble mission of caring for the local patients. With strong growth plans, this is investing is a new multiproduct general formulation plant which should be the biggest in Algeria with an area of 17,500 sqm. The plant will be first one to manufacture Soft gelatin capsules in the country. Apart from the Oral solid dosage forms, they have high volume lines coming up to manufacture liquid oral in bottles and stick packs and ointment line. Pharma Access is executing this project on a Turnkey basis (excluding filling & packing lines). The project in ongoing in Algiers and is expected to be completed by November 2020. ...
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On May 13, 1986, the Drug Enforcement Administration (DEA) issued a Final Rule and Statement of Policy authorizing the rescheduling of synthetic dronabinol in sesame oil and encapsulated in soft gelatin capsules from Schedule I to Schedule II (DEA 51 FR 17476-78). This permitted medical use of Marinol, albeit with the severe restrictions associated with Schedule II status.[13] For instance, refills of Marinol prescriptions were not permitted. At its 10th meeting, on April 29, 1991, the Commission on Narcotic Drugs, in accordance with article 2, paragraphs 5 and 6, of the Convention on Psychotropic Substances, decided that Δ⁹-tetrahydrocannabinol (also referred to as Δ⁹-THC) and its stereochemical variants should be transferred from Schedule I to Schedule II of that Convention. This released Marinol from the restrictions imposed by Article 7 of the Convention (See also United Nations Convention Against Illicit Traffic in Narcotic Drugs and Psychotropic Substances).[citation needed]. An ...
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Novel oil-filled microcapsules were prepared by introducing a phase separation method using ethyl cellulose as a shell-forming containing rapeseed oil. The prepared oil-filled microcapsules were evaluated by optical microscopy, scanning electron microscopy and particle size analysis. Results showed that spherical microcapsules with a diameter of 10 to 45 μm and a rough porous shell were obtained. Carboxylated styrene/butadiene copolymer latex films containing various levels of these microcapsules were subjected to various levels of pre-elongation and their tensile properties were examined. The addition of oil-filled microcapsules resulted in a significant improvement in the modulus, strain-to-break, and toughness of the films. The self-healing mechanism of latex films was examined through the colorimetric measurements of the release of dye-containing following the pre-elongation of the samples. These measurements confirmed that pre-elongation of samples resulted in the release of oil within the ...
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Disclosed is a microcapsule composition for inhibiting an ethylene response in plants, which comprises a plurality of microcapsules, each including an agent for blocking an ethylene binding site in plants in an oil droplet, and a coating encapsulating the oil droplet and the agent for blocking the ethylene binding site in plants. A method for preparing microcapsules of an agent for blocking the ethylene binding site in plants, and a method for inhibiting an ethylene response in plants are also disclosed.
Microencapsulation of recombinant cells is a novel promising approach to tumor therapy in which therapeutic protein is sustainable and long-term delivered by microencapsulated cells. The semi-permeable membrane of microcapsule can protect cell from hosts immune rejection, increase the chemical stability of therapeutic protein and circumvent the problems of toxicity, limited half-lives and variation in circulating levels. Endostatin, a potent and specific angiogenesis inhibitor, could suppress the growth of primary and metastatic lesions in multiple murine tumor models. In this paper, APA microcapsules with high strength kept intact over 35 days and recombinant CHO cells kept the rapid proliferation viability and the continuous endostatin-expression function. The study of tumor treatment showed that the implantation of microencapsulated recombinant CHO cells decreased the neovascularization of tumor tissue by 59.4% and inhibited the B16 melanoma growth by 77.4%. Twenty days after tumor cell ...
SOARES DE OLIVEIRA CARVALHO, Anna Paula; KIMI UEHARA, Sofia; FIRMINO NOGUERIA NETTO, José and ROSA, Glorimar. Hypocaloric diet associated with the consumption of jam enriched with microencapsulated fish oil decreases insulin resistance. Nutr. Hosp. [online]. 2014, vol.29, n.5, pp.1103-1108. ISSN 1699-5198. http://dx.doi.org/10.3305/nh.2014.29.5.6654.. Background: The metabolic syndrome is related to the increase in cardiovascular diseases. Polyunsaturated fatty acids from fish oil help in reducing cardiovascular risk factors and are natural bindings of PPARy2. Objective: To evaluate the impact of hypocaloric diet associated with microencapsulated fish oil supplementation in women with metabolic syndrome. Methods: We conducted a randomized, single-blind and placebo-controlled clinical trial with adult women who presented metabolic syndrome (n = 30) for 90 days. The volunteers were divided into two groups: placebo group (n = 15) and microencapsulated fish oil group (n = 15) (3 g/day of ...
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TY - JOUR. T1 - Distribution of PEG-coated hollow polyelectrolyte microcapsules after introduction into the circulatory system and muscles of zebrafish. AU - Borvinskaya, Ekaterina. AU - Gurkov, Anton. AU - Shchapova, Ekaterina. AU - Baduev, Boris. AU - Meglinski, Igor. AU - Timofeyev, Maxim. N1 - This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. PY - 2018/1/5. Y1 - 2018/1/5. N2 - The use of polyelectrolyte multilayer microcapsules as carriers for fluorescent molecular probes is a prospective technique for monitoring the physiological characteristics of animal vasculature and interstitial environment in vivo. Polyelectrolyte microcapsules have many features that favor their use as implantable carriers of optical sensors, but little information is available on their ...
Effexor (Venlafaxine) 75mg capsule: Effexor (Venlafaxine) treats depression. Effexor XR® also treats panic disorder, social anxiety disorder, and generalized anxiety disorder. This medicine is a serotonin and norepinephrine reuptake inhibitor (SNRI). You can buy Effexor (Venlafaxine) 75mg capsules online without prescription (No RX). product price is as: per capsule Minimum order quantity is: 100 capsules
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Capsugel is the first hard capsule manufacturer to receive the EXCiPACT™ certification. The certification provides independent validation that Capsugels European manufacturing sites maintain excipient Good Manufacturing Practices (GMPs) and comply with current European Union regulations in the manufacturing of empty, two-piece hard capsules.This webinar covers the regulatory background regarding the EU Directive on Falsified Medicines, the process and scope of the EXCiPACT™ excipient GMP certification, and the related benefits to companies marketing pharmaceutical products in the European Union.
Bicentennial fountain and time capsule[edit]. The town's Bicentennial fountain is located at the corner of Quality Street and ... In 1997 a time capsule was laid at the base of the Bicentennial Fountain with an opening date of October 12, 2097, Trumbull's ...
Soft-gel capsules with CoQ10 in oil suspension[edit]. A successful approach was to use the emulsion system to facilitate ... could be stabilised very effectively by lecithin and were used in the preparation of soft gelatin capsules. In one of the first ... with oil-based softgel capsules in a later study on dogs,[49] the significantly increased bioavailability of CoQ10 was ... with many of them producing significantly better results over oil-based softgel capsules in spite of the many attempts to ...
Capsule[edit]. Thin reticular fibers of reticular connective tissue form a supporting meshwork called reticulin inside the node ... The lymph node capsule is composed of dense irregular connective tissue with some plain collagenous fibers, and a number of ... When lymph fluid enters a node, it drains into the node just beneath the capsule in a space called the subcapsular sinus. The ... The larger trabeculae springing from the capsule break up into finer bands, and these interlace to form a mesh-work in the ...
Capsule[edit]. A capsule containing THC or CBD that is not sold as a regulated pharmaceutical is also considered an edible and ...
Reentry capsule[edit]. Along with resupplying the ISS, this Kounotori flight tested the HTV Small Re-entry Capsule (HSRC), a ... The capsule can contain a total of 20 kg of material (5 kg if the payload requires refrigeration).[5] The capsule has a ... ground control will remotely command Kounotori to release the capsule at an altitude of 300 kilometres (190 mi).[5] The capsule ... On 22 October 2015, a high-altitude drop test of the capsule was successfully conducted off the coast of Taiki, Hokkaido.[11] A ...
Escape capsule inaccessible[edit]. In an emergency, personnel in the rear compartments were to move forward to the third ... One of the rescue capsules was damaged by the storm.[29] On Thursday at 12:00, Popov reported to the General Staff of the Navy ... The rescue capsule in the third compartment was inaccessible, even if it was still usable.[10] ... compartment along with those in the forward compartments and enter a detachable rescue capsule in the sail (or conning tower), ...
Capsule Servers[edit]. Capsule Servers mirror content from the Satellite Server to establish content sources in different ... The Red Hat Satellite Server enables planning and management of the content life cycle and the configuration of Capsule Servers ... A Puppet Master server installed as part of a Red Hat Satellite 6 Master Server or Capsule server ...
Capsule[edit]. Certain strains of S. haemolyticus are capable of producing a capsular polysaccharide (CP).[9][12] S. ... haemolyticus strain JCSC1435 contains a capsule operon located within the "oriC environ".[9] This operon contains 13 ORFs in a ...
Westinghouse time capsule[edit]. In 1938, he wrote a short passage to be placed in the Westinghouse Time Capsules.[34] ... The Time Capsule. Westinghouse Electric & Manufacturing Company. September 23, 1938. p. 46. ...
Capsule. A gelatinous capsule is present in some bacteria outside the cell membrane and cell wall. The capsule may be ... Capsules are not marked by normal staining protocols and can be detected by India ink or methyl blue; which allows for higher ... may be further covered by a third layer called a capsule. Though most prokaryotes have both a cell membrane and a cell wall, ...
Capsules. The IV injection and inhalation preparations are, in general, prescription only, whereas the oral solution and the ... Acetylcysteine is available as a health supplement in the United States, typically in capsule form. ...
August 30, 1976). "Medicine: Capsules". Time. 108 (9). p. 58. Brody, Jane E. (September 12, 1976). "A chromosome link to crime ...
In 2013, BMS charged $50 a capsule. In 2018, NextSource charged $768 a capsule. Some doctors said the price increase made it ... CeeNu (lomustine) Capsules data sheet published by the FDA. *Lomustine at the US National Library of Medicine Medical Subject ... "Gleostine (lomustine) Capsules, for Oral Use. Full Prescribing Information" (PDF). NextSource Biotechnology, LLC. Retrieved 15 ...
It bears many minute brown seeds, about 300 to 400 per capsule and 80,000 per plant. The seeds have silky hairs to aid wind ... The upright, reddish-brown linear seed capsule splits from the apex and curls open. ...
"Talzenna 0.25 mg hard capsules - Summary of Product Characteristics (SmPC)". (emc). 1 June 2021. Retrieved 9 July 2021.. ...
Fish oil capsules. Marine and freshwater fish oil vary in content of arachidonic acid, EPA and DHA.[120] They also differ in ...
"Isotretinoin 20mg capsules - - (eMC)". www.medicines.org.uk. Retrieved 2017-12-27.. ... "Isotretinoin 20mg capsules - - (eMC)". www.medicines.org.uk. Retrieved 2018-01-10.. ... "Roaccutane 20mg Soft Capsules - Summary of Product Characteristics". UK Electronic Medicines Compendium. 1 July 2015.. ... "Isotretinoin (marketed as Accutane) Capsule Information". U.S. Food and Drug Administration (FDA). 2018-11-03.. ...
"CHEMMART PIROXICAM CAPSULES" (PDF). TGA eBusiness Services. Apotex Pty Ltd. 18 December 2013. Archived from the original on 15 ... "PRODUCT INFORMATION PONSTAN CAPSULES (mefenamic acid)" (PDF). TGA eBusiness Services. Pfizer Australia Pty Ltd. 12 October 2012 ...
The WHO Model List of Essential Medicines (EML), published by the World Health Organization (WHO), contains the medications considered to be most effective and safe to meet the most important needs in a health system.[1] The list is frequently used by countries to help develop their own local lists of essential medicine.[1] As of 2016[update], more than 155 countries have created national lists of essential medicines based on the World Health Organization's model list.[2] This includes countries in both the developed and developing world.[1][3] The list is divided into core items and complementary items.[4] The core items are deemed to be the most cost-effective options for key health problems and are usable with little additional health care resources.[4] The complementary items either require additional infrastructure such as specially trained health care providers or diagnostic equipment or have a lower cost-benefit ratio.[4] About 25% of items are in the complementary list.[5] Some ...
The Old English name of the animal was efte, efeta (of unknown origin), resulting in Middle English eft; this word was transformed irregularly into euft, evete, or ewt(e). The initial 'n' was added from the indefinite article 'an' by provection (juncture loss) ("an eft" -, "a n'eft" -, ...) by the early 15th century.[2] The form 'newt' appears to have arisen as a dialectal variant of eft in Staffordshire, but entered Standard English by the Early Modern period (used by Shakespeare in Macbeth iv.1).[3] The regular form eft, now only used for newly metamorphosed specimens, survived alongside newt, especially in composition, the larva being called "water-eft" and the mature form "land-eft" well into the 18th century, but the simplex "eft" as equivalent to "water-eft" has been in use since at least the 17th century.[4] Dialectal English and Scots also has the word ask (also awsk, esk in Scots[5]) used for both newts and wall lizards, from Old English āþexe, from Proto-Germanic *agiþahsijǭ, ...
Crixivan® (indinavir sulfate) Capsules. Whitehouse Station, New Jersey: Merck Sharp & Dohme Corporation. Archived (PDF) from ...
"By-Mycin 50mg capsules". medicines.ie: Medicines information online. Dublin, Ireland: Irish Pharmaceutical Healthcare ...
Capsule. 40-80 mg/2-4x day (with meals) Methyltestosteroneb. Android, Metandren, Testred. Tablet. 10-50 mg/day ...
... the bones have a synovial cavity and are united by the dense irregular connective tissue that forms the articular capsule that ...
... when taken in capsule or tablet form.[14][15] Momordica charantia may be beneficial in diabetes; however, the effects seem to ...
"Aptivus (tipranavir) Capsules, Oral Solution. Full Prescribing Information" (PDF). Boehringer Ingelheim Pharmaceuticals, Inc. ...
The calyx of Hibiscus trionum has opened apically to reveal the capsule (ovary) inside. The capsule has split vertically in the ... Spathoglottis plicata capsules, like in most orchids, split longitudinally along three to six slits while remaining closed at ... Iridaceae capsules have loculicidal dehiscence; the fruit splits through the ovary wall of each carpel, allowing the seeds to ... The septa between the locules of Ledum palustre capsules split as the fruit opens, and the seeds are released. ...
The joint capsule is a soft tissue envelope that encircles the glenohumeral joint and attaches to the scapula, humerus, and ... The capsule is a soft tissue envelope that encircles the glenohumeral joint and attaches to the scapula, humerus, and head of ... This capsule is strengthened by the coracohumeral ligament which attaches the coracoid process of the scapula to the greater ... This tendon, along with the articular capsule, the coracohumeral ligament, and the glenohumeral ligament complex, blend into a ...
"Omnicef capsules Patient Information" (PDF). Abbott Laboratories. February 2004. Archived from the original (PDF) on 2006-11-18 ... It is available as capsules and a suspension. Dosage, schedule, and duration of therapy varies according to the type of ...
... Limited (帝人株式会社, Teijin Kabushiki-gaisha) is a Japanese chemical, pharmaceutical and information technology company. Its main fields of operation are high-performance fibers such as aramid, carbon fibers & composites, healthcare, films, resin & plastic processing, polyester fibers, products converting and IT products. The company is listed on the first section of the Tokyo Stock Exchange and is a constituent of the Nikkei 225 stock index.[3] As of March 2014, the Teijin Group comprises 151 companies, 56 in Japan and 95 overseas.[1] Teijin is a member of the Mitsubishi UFJ Financial Group (MUFJ) keiretsu. ...
Doxycycline Capsules Used Treat. Save On Prescription Drugs Online Or By Mail Order. Offering Low Priced Generic And Brand ... Advertisers shown in doxycycline capsules used treat reaches are capsule for informational areas personal and are quickly 6- ... Americans and doxycycline capsules used treat the tick-borne is made by a cvs effects and have been and subverted with the ... Not, doxycycline capsules used treat the next particularit is the low to describe the appointments of vasehair on tests of ...
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Pharmaceutical Capsules is an essential resource for all those involved in the development, manufacture and testing of capsules ... this updated and expanded second edition covers all aspects of capsule technology, including history, standards, methods and ... equipment used in manufacture, filling, printing, weighing, cleaning and inspecting of both hard and soft capsules. ... blister capsule body capsule filling capsule formulations capsule products capsule shell capsules containing capsules per hour ...
Ricky Barnes birdied six of the last eight holes Thursday at rain-softened TPC Louisiana to take a one-stroke lead in the Zurich Classic.
ANAHEIM, Calif. - Andrelton Simmons drove in three runs, including a go-ahead two-run homer, Albert Pujols went 3 for 4 with two RBIs and the Los Angeles Angels rallied for a 7-3 victory over the Boston Red Sox on Saturday night.
BOSTON - Salvador Perez and Mike Moustakas homered off emergency starter Rick Porcello, who took over when David Price went back on the disabled list because of inflammation in his left elbow, and the Kansas City Royals beat Boston 4-2 Friday night for their season-high ninth straight win.
Note that FMA has classes such as Articular capsule that are not subtypes of Capsule (which is undefined in FMA). GO has ... Examples: egg shell, articular capsules, renal capsules[WP]. [ http://en.wikipedia.org/wiki/Capsule_(anatomy) ] ... capsule which is a fungal structure, and external encapsulating structure which is restricted to cells ... capsule. Go to external page http://purl.obolibrary.org/obo/UBERON_0003893 Copy ...
Were launching our Trusts Time Capsule Competition today! In this competition we are challenging our children to work on ... And of course, this is also an invitation to create their very own Time Capsule! ... their own, in pairs or a group of three to develop or represent five things for their time capsule, (to be opened in 10 years ...
Heritage Time Capsules Congressional Time Capsule 2009. *The book of record of the time capsule of Cupaloy - New York Worlds ... New York Times Capsule in NYC. *The Jubilee Time Capsule - The Royal Commonwealth Societys Jubilee Time Capsule to celebrate ... The 1939 time capsule was followed in 1965 by a second capsule at the same site, but 10 feet (3.0 m) to the north of the ... A time capsule dating to 1777 was discovered within a religious statue in Sotillo de la Ribera.[6] A time capsule was ...
In this video, we review the concept of Satellite 6 remote capsules and how they can be used to centrally management multiple ... environments and geographic sites, their relationship to the primary integrated management capsule, and how to load balance ... In this video, we review the concept of Satellite 6 remote capsules and how they can be used to centrally management multiple ... environments and geographic sites, their relationship to the primary integrated management capsule, and how to load balance ...
Capsule of lens. The upper half of a sagittal section through the front of the eyeball. (Capsule of lens labeled at center ... The lens capsule is a component of the globe of the eye. It is a clear, membrane-like structure that is quite elastic, a ... Retrieved from "https://en.wikipedia.org/w/index.php?title=Capsule_of_lens&oldid=608972175" ...
BANGOR Coach: Frank Scagliotta (third year, 142-101-2) Last year: 1-9 (1-9 Colonial) Impact players: WR/OLB Dyvek Ott, sr.; TE/LB Corbin Moffett, sr.; RB/DB Shane Yetter, sr.; QB/RB/DB Scott LaValva, so.; RB/LB Ryan Fraunfelter; FB/LB Evan Brown, sr.; WR/DB Brian Smith, sr. (transfer from Pius...
No. 1 ARIZONA (25-3) NCAA HISTORY: 22nd appearance, 19th straight. Four Final Fours, champ in 1997, runner-up in 2001. Lost to Oklahoma in last year's West semis. COACH: Lute Olson (39-23 in NCAA). STARTERS: F Luke Walton, F Rick Anderson, C Channing Frye, G Jason Gardner, G Salim Stoudamire. OUTLOOK:...
... capsules have been approved to treat adults with intermediate-2 or high-risk primary or secondary myelofibrosis, making it the ... home/cancer center/ cancer a-z list/ fda approves inrebic capsules for myelofibrosis article ... 16, 2019 (HealthDay News) -- Inrebic (fedratinib) capsules have been approved to treat adults with intermediate-2 or high-risk ...
GROUP A DENMARK World Cup Record: Played 9, won 5, lost 3, tied 1, goals for 19, goals against 13. Best Finish: Quarterfinalist, 1998. 1998 Showing: Lost in the quarterfinals to Brazil. Coach: Morten Olsen. Played on the Danish Dynamite team that lit up the 1986 World Cup in Mexico. Players to...
A capsule is essentially a finite coalgebraic representation of a regular closed λ-coterm. One can give an operational ... Recursive functions are represented directly as capsules without the need for unnatural and untypable fixpoint combinators. 1 ... Capsules provide a clean algebraic representation of the state of a computation in higherorder functional and imperative ... semantics based on capsules for a higher-order programming language with functional and imperative features, including mutable ...
Interleague Capsules Share this:. *Click to share on Facebook (Opens in new window) ...
Dows ingredients for gelatin capsule formulations enhance API solubility, while having low impurities to avoid cross linking ... Consumers prefer gelatin capsules over other dosage forms, so the development of drugs in this form is more relevant than ever. ... CARBOWAX™ SENTRY™ LPEG and MPEGs are pharmaceutical excipients which can be used in the manufacturing of capsules as ... CARBOWAX™ SENTRY™ Polyethylene Glycols (PEGs) have a long history of use in capsule formulations because they meet all ...
Capsule, in botany, dry fruit that opens when ripe. It splits from apex to base into separate segments known as valves, as in ... The capsule is often covered by a calyptra, which is the enlarged remains of the archegonium. The capsule is capped by an ... legumes, and capsules. Follicles and legumes are each derived from an ovary with a single carpel, and a capsule is derived from ... Capsule, in botany, dry fruit that opens when ripe. It splits from apex to base into separate segments known as valves, as in ...
Capsule is a single-player survival game played entirely through a radar interface. Players navigate a hostile landscape, learn ... Capsule is a short game, approximately 2 hours for most players. Capsule is not a game for everyone; if you are claustrophobic ... You wake up inside a small capsule, trapped, with no view of the outside world. The only way to survive is to use the radar ... Capsule is a single-player survival game played entirely through a radar interface. Players navigate a hostile landscape, learn ...
AirPort Time Capsule lets you back up your files with AirPort Time Capsule with 2TB memory space. Get fast, free shipping when ... AirPort Time Capsule includes a 2TB or 3TB hard drive that works with Time Machine in OS X to create the perfect no-hassle ... AirPort Time Capsule can turn any external USB hard drive into a secure drive you can share across your Wi-Fi network. So all ... I took it to t I bought this Time Capsule 18 months ago and a few days ago, it started to have a loud whirring and occasion ...
"Bring Time Capsule home, plug it in, click a few buttons on your Macs and voila-all the Macs in your house are being backed up ... Time Capsule offers the benefits of a full-featured 802.11n Wi-Fi base station, and comes in two models: a 500 gigabyte model ... Time Capsule combines an 802.11n base station with a server grade hard disk in one small package. Simply plug it in, then ... Time Capsule features a sleek design with a built-in power supply and connections to print wirelessly to a USB printer. With ...
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Additionally, the 10 mg capsule contains D&C Yellow 10 and FD&C Yellow 6, the 25 mg capsule contains D&C Yellow 10 and FD&C ... Each capsule for oral administration, contains loxapine succinate, USP 6.8 mg, 13.6 mg, 34.0 mg or 68.1 mg equivalent to 5 mg, ... Loxapine capsules are administered, usually in divided doses, two to four times a day. Daily dosage (in terms of base ... Loxapine capsules, USP are available in the following strengths:. Loxapine succinate, USP 6.8 mg equivalent to 5 mg loxapine, ...
... are available as 25 mg, 50 mg and 100 mg two-piece hard gelatin capsules. The capsules are printed in black ... Zonisamide Capsules Read this Medication Guide before you start taking zonisamide capsules and each time you get a refill. ... Swallow the capsules whole.. *If you take too many zonisamide capsules, call your local Poison Control Center or go to the ... What is Zonisamide Capsule? Zonisamide capsule is a prescription medicine that is used with other medicines to treat partial ...
... SCHEDULING STATUS:. S1. PROPRIETARY NAME. (and dosage form):. GENASMA CAPSULES. COMPOSITION:. Each capsule ... A capsule with a transparent orange body and a transparent blue cap, containing a white powder.. PRESENTATION:. Containers of ... One to five capsules in any 24 hour period.. In view of the many factors affecting theophylline clearance, serum concentration ...
Capsules or Tea?. The research to this point has focused on peppermint oil capsules, not on peppermint leaves like you find in ... They can break down the coating on the capsules and make your heartburn worse. And remember to swallow the capsules, not chew ... Theres no harm in drinking peppermint tea, but only the capsules have been shown to be effective. Plus, with capsules, you ... Make sure to look for enteric-coated capsules. The coating keeps your stomach juices from breaking down the capsules. That way ...
A new type of drug capsule might one day replace the need to take medicines every day, but so far it has only been tested in ... After the capsule is swallowed, stomach acid dissolves the outer layer of the capsule, and the six arms unfold. Once the star ... A capsule that contains a six-armed star containing drugs can remain in the stomach and release its medication over time. That ... The capsule can be applied to many conditions, including Alzheimers disease, HIV, schizophrenia or kidney disease, he said. ...
  • Thanks Paul, I wonder if you would be able to answer this, did it affect any pages rankings on search engines when the capsules disapeared from hubs and were there fewer visitors to hubs that contained news capsules? (hubpages.com)
  • Writer patient studies from doxycycline are expensive bacterial but it can cause time, synthesis and a expired" effectsside in capsules some costs. (unionmusicaldebenidorm.com)
  • We're launching our Trust's Time Capsule Competition today! (google.com)
  • In this competition we are challenging our children to work on their own, in pairs or a group of three to develop or represent five things for their time capsule, (to be opened in 10 years - if you wish to do that! (google.com)
  • And of course, this is also an invitation to create their very own Time Capsule! (google.com)
  • For other uses, see Time capsule (disambiguation) . (wikipedia.org)
  • A time capsule is a historic cache of goods or information, usually intended as a deliberate method of communication with future people, and to help future archaeologists , anthropologists , or historians . (wikipedia.org)
  • Time capsules are sometimes created and buried during celebrations such as a world's fair , a cornerstone laying for a building, or at other ceremonies. (wikipedia.org)
  • It is widely debated when time capsules were first used, but the concept is fairly simple, and the idea and first use of time capsules could be much older than is currently documented. (wikipedia.org)
  • [3] The term "time capsule" appears to be a relatively recent coinage dating from 1938. (wikipedia.org)
  • A time capsule dating to 1777 was discovered within a religious statue in Sotillo de la Ribera. (wikipedia.org)
  • A Revolutionary-era time capsule , dating to 1795 and credited to Samuel Adams and Paul Revere , was temporarily removed in 2014 from the cornerstone of the Massachusetts State House in Boston. (wikipedia.org)
  • [8] [10] It is the oldest known time capsule in the United States. (wikipedia.org)
  • In 1901, a time capsule was placed inside the head of the copper lion ornamenting the Old State House in Boston. (wikipedia.org)
  • The Crypt of Civilization (1936) at Oglethorpe University , intended to be opened in 8113 , is claimed to be the first "modern" time capsule, although it was not called one at the time. (wikipedia.org)
  • George Edward Pendray is responsible for coining the term time capsule . (wikipedia.org)
  • [14] [15] During the socialist period in the USSR , many time capsules were buried with messages to a future communist society. (wikipedia.org)
  • The 1939 New York World's Fair time capsule was created by Westinghouse as part of their exhibit. (wikipedia.org)
  • The 1939 time capsule was followed in 1965 by a second capsule at the same site, but 10 feet (3.0 m) to the north of the original. (wikipedia.org)
  • Both the 1939 and 1965 Westinghouse Time Capsules are meant to be opened in 6939 . (wikipedia.org)
  • However, this time capsule was never put in place. (wikipedia.org)
  • There is documentation of at least three physical time capsules at the Massachusetts Institute of Technology (MIT) in Cambridge, Massachusetts , as well as a "virtual" or digital time capsule. (wikipedia.org)
  • I can't imagine the time it would take to switch out every capsule in a prescription. (drugs.com)
  • Back up a lifetime's worth of memories with AirPort Time Capsule, a wireless hard drive that works seamlessly with Time Machine in OS X. It's also a full-featured Wi-Fi base station with the latest 802.11ac technology and simultaneous dual-band support. (apple.com)
  • AirPort Time Capsule includes a 2TB or 3TB hard drive that works with Time Machine in OS X to create the perfect no-hassle backup solution. (apple.com)
  • With 802.11ac technology and a powerful beamforming antenna array, AirPort Time Capsule gives you up to 3x faster Wi-Fi and a stronger, clearer signal. (apple.com)
  • With the antennas at the top of the elevated design, AirPort Time Capsule now has a higher platform for dispersing the signal. (apple.com)
  • Connect your DSL or cable modem to AirPort Time Capsule and use the built-in setup assistant to create your new wireless network in just a few taps from your iPhone, iPad, or iPod touch. (apple.com)
  • AirPort Time Capsule can turn any external USB hard drive into a secure drive you can share across your Wi-Fi network. (apple.com)
  • Any Wi-Fi device you have will work with AirPort Time Capsule. (apple.com)
  • And since AirPort Time Capsule features a built-in firewall that protects your network from malicious Internet attacks, you can enjoy the web with peace of mind. (apple.com)
  • MACWORLD SAN FRANCISCO-January 15, 2008-Apple® today introduced Time Capsule, a backup appliance that automatically and wirelessly backs up everything on one or more Macs running Leopard™, the latest release of Apple's Mac OS® X operating system including the amazing Time Machine™ automatic backup software. (apple.com)
  • Time Capsule combines an 802.11n base station with a server grade hard disk in one small package. (apple.com)
  • Simply plug it in, then easily set up automatic wireless backup for every Mac® in your house to a single Time Capsule with just a few clicks. (apple.com)
  • Time Capsule offers the benefits of a full-featured 802.11n Wi-Fi base station, and comes in two models: a 500 gigabyte model for just $299 and a 1 terabyte model for just $499. (apple.com)
  • Bring Time Capsule home, plug it in, click a few buttons on your Macs and voila-all the Macs in your house are being backed up automatically, every hour of every day," said Steve Jobs, Apple's CEO. (apple.com)
  • With Time Capsule and Time Machine, all your irreplaceable photos, movies and documents are automatically protected and incredibly easy to retrieve if they are ever lost. (apple.com)
  • Built to work seamlessly with Time Machine, Time Capsule lets users wirelessly back up all of the data on their Macs, find lost files and even restore all of their software. (apple.com)
  • If it's ever necessary, Leopard can also easily restore an entire system from the Time Machine backup on Time Capsule. (apple.com)
  • In addition to being the best way to back up a Mac, Time Capsule is also a full-featured Wi-Fi base station with the latest 802.11n technology. (apple.com)
  • Time Capsule features a sleek design with a built-in power supply and connections to print wirelessly to a USB printer. (apple.com)
  • With Time Capsule, it's very easy for users to create a secure, wireless network for up to 50 users and set security restrictions such as Internet access limits for children's computers. (apple.com)
  • At $299 for a 500GB model and $499 for a 1TB model and a fully integrated 802.11n AirPort Extreme® Base Station, Time Capsule can serve as a backup solution for multiple computers as well as the backbone for a high-speed, 802.11n wireless network, making it effortless and affordable for everyone at home, school or work to protect their digital files. (apple.com)
  • Time Capsule will be available in February through the Apple Store® ( www.apple.com ), at Apple's retail stores and Apple Authorized Resellers for a suggested retail price of $299 (US) for a 500GB hard drive and $499 (US) for a 1TB hard drive. (apple.com)
  • Time Capsule is based on an IEEE 802.11n draft specification. (apple.com)
  • Can Time-Release Capsules Replace Daily Pills? (medicinenet.com)
  • health & living center / prevention & wellness a-z list / can time-release capsules replace daily pills? (medicinenet.com)
  • A capsule that contains a six-armed star containing drugs can remain in the stomach and release its medication over time. (medicinenet.com)
  • Could you please tell me what the 'time capsule' means in the following context? (usingenglish.com)
  • A 'time capsule' is usually a box that is sealed and often buried containing items typical of the time, like newspapers, magazines or anything else that is suggested as representing life at that time. (usingenglish.com)
  • I understand the original meaning of 'time capsule' (I actually made it when I was younger), but I suppose this is used as a different meaning in that context. (usingenglish.com)
  • what goes into a time-capsule are usually everyday items which nevertheless are iconic of the age. (usingenglish.com)
  • To say his 'stupid remark' is going into a time-capsule suggests that it is the epitome of all stupid remarks ever to be made. (usingenglish.com)
  • In my language we would not use 'time capsule' to express such a meaning. (usingenglish.com)
  • A milestone birthday, a college party house, and an eighteen-year-old time capsule. (newyorker.com)
  • Everybody had turned forty or was about to, so, even though the time capsule had been in the ground for only eighteen years, not a significant number, we decided to dig it up. (newyorker.com)
  • Then, at once, before you knew it, the time for the Time-Capsule Party had arrived-a last hurrah. (newyorker.com)
  • Although we believe this to be a local isolated incident,' said Bristol-Myers spokesman Jerry Parrott in New York, 'we are also asking all stores throughout the United States to quarantine excedrin capsules for the time being and to remove excedrin capsules from store shelves until we have more information from stores in Auburn. (upi.com)
  • At the current time, we're advising the general public in the Seattle area about the Excedrin capsule problem and warning them not to gake the Excedrin capsule product until more is known,' said Chris Rezendes, an FDA spokesman in Seattle. (upi.com)
  • There is an extremely high risk that severe birth defects will result if pregnancy occurs while taking isotretinoin capsules in any amount, even for short periods of time. (biospace.com)
  • Most of the time, the capsule leaves the body within 24 hours. (medlineplus.gov)
  • A time capsule set Sept. 23, 1925 in the cornerstone of the former Philadelphia Fire Department headquarters at 1328 Race Street is opened. (philly.com)
  • Back in May, I kicked off a Trump Time Capsule series, designed to note what we knew, when we knew it, about the man who was trying to become president. (theatlantic.com)
  • The thought occurred to me: This should be in the Trump Time Capsule. (theatlantic.com)
  • In the meantime, please check out, follow, and contribute to a very interesting Time Capsule project by @motocollard , which you can read about on Medium . (theatlantic.com)
  • Back during the 2016 campaign, I put out 152 installments of the Trump Time Capsule series, chronicling what was known about this man at just the time the Republican party was deciding to accept (and then embrace) him as its nominee, and as the states of Michigan, Wisconsin, and Pennsylvania were delivering him an Electoral College win. (theatlantic.com)
  • At last week's village council meeting, she presented two time capsules to Walbridge officials, plus a centennial-year scrapbook to be kept on reserve at the Walbridge Branch of the Wood County Library System that librarian Matt Mehling accepted. (toledoblade.com)
  • The time capsules, which actually are two safes, will be sealed this week. (toledoblade.com)
  • But by making time capsules, we can decide what message to send to the future about our own lives. (amnh.org)
  • The American Museum of Natural History has its own time capsule. (amnh.org)
  • Many people suggested words, objects, and music for the time capsule. (amnh.org)
  • Check out what these kids collected for their time capsules. (amnh.org)
  • Now try making your own time capsule. (amnh.org)
  • Think about what messages you want your time capsule to send. (amnh.org)
  • Decide when your time capsule should be opened and write the date on the lid. (amnh.org)
  • Now it's time to put away your time capsule. (amnh.org)
  • Her task as head of objects conservation at Boston's Museum of Fine Arts was to retrieve items which were first place in a time capsule at the State House in 1795. (telegraph.co.uk)
  • Adams and Revere were joined in creating the original time capsule by a lesser known revolutionary figure, Colonel William Scollay, who served in the local Boston Militia. (telegraph.co.uk)
  • On loan from the Smithsonian Institution, the capsule is departing the Naval Academy to be displayed at the John F. Kennedy Presidential Library and Museum at Columbia Point in Boston, Mass. (space.com)
  • Each capsule contains the labeled amount of zonisamide plus the following inactive ingredients: microcrystalline cellulose, hydrogenated vegetable oil, gelatin, and titanium dioxide. (nih.gov)
  • Vats at a Zhejiang capsule maker suspected of using industrial gelatin. (wsj.com)
  • China's state-run China Central Television network reported Sunday that the toxic drug capsules had been made from industrial gelatin, which contains more of the chemical chromium than edible gelatin. (wsj.com)
  • As a dietary supplement, take 2 capsule daily or as directed by a healthcare professional. (gnc.com)
  • As a dietary supplement, take 2 capsules once per day. (fungi.com)
  • WEDNESDAY, Nov. 16, 2016 (HealthDay News) -- A new type of drug capsule might one day replace the need to take medicines every day, but so far it has only been tested in pigs, researchers report. (medicinenet.com)
  • The State Food and Drug Administration said in a statement Sunday it asked local authorities in China to inspect drug-capsule manufacturers in their provinces. (wsj.com)
  • In anatomy , a joint capsule or articular capsule is an envelope surrounding a synovial joint . (wikipedia.org)
  • [1] Each joint capsule has two parts: an outer fibrous layer or membrane, and an inner synovial layer or membrane. (wikipedia.org)
  • The fibrous membrane of the joint capsule is attached to the whole circumference of the articular end of each bone entering into the joint, and thus entirely surrounds the articulation. (wikipedia.org)
  • The joint capsule of the elbow has sides that are thickened by ulnar and radial collateral ligaments. (innerbody.com)
  • 11-20-2017] The Food and Drug Administration (FDA) is advising consumers not to purchase or use Control Capsules, a product promoted for sexual enhancement. (fda.gov)
  • FRIDAY, Aug. 16, 2019 (HealthDay News) -- Inrebic (fedratinib) capsules have been approved to treat adults with intermediate-2 or high-risk primary or secondary myelofibrosis, making it the second drug approved to treat patients with this disease, the U.S. Food and Drug Administration announced today. (medicinenet.com)
  • Tablets on effective rhythm of amoxil capsule 250mg dose and medication ré is restricted. (goorganics.us)
  • There are several brands of acai berry capsules on the market and you should make sure to check how many times per day you should take the tablets to get the most weight-loss and antioxidant benefits from your supplements. (selfgrowth.com)
  • Photo source: FDA Aurobindo Pharma USA is recalling one lot of Ranitidine tablets, 37 lots of Ranitidine capsules and Ranitidine syrup. (consumeraffairs.com)
  • Contact your smell if you experience these content studies and doxycycline capsules used treat they are i' or marked. (unionmusicaldebenidorm.com)
  • It seems the News Capsule is now out of favour.That's a bummer, because over the last couple of years, it's been recommended as a great thing to add your Hubs to keep the content 'fresh'.As a result, I (and many other Hubbers) have a News capsule on every @##$%^& Hub. (hubpages.com)
  • It is often said that we need to include news capsules to keep our content fresh. (hubpages.com)
  • They simply do their keyword research, post content and let it be.I understand the value of the RSS capsule with your latest hubs. (hubpages.com)
  • Filter-content material for the individual capsules is extruded as a stream through the central opening and a settable coating liquid material is extruded as a thin film sleeve circumferentially of the filler-content material stream. (google.com)
  • The spring 2021 capsule collection is expected to be released on June 10. (wwd.com)
  • MAPLE GROVE, Minn. , June 25, 2021 /PRNewswire/ -- Upsher-Smith Laboratories, LLC (Upsher-Smith) today announced the launch of Isotretinoin Capsules. (biospace.com)
  • The isotretinoin capsule market had U.S. sales of approximately $156 million for the 12 months ending April 2021 according to IQVIA. (biospace.com)
  • And remember to swallow the capsules, not chew them. (webmd.com)
  • That means instead of taking daily medication, patients would only have to swallow one capsule weekly or monthly, the researchers said. (medicinenet.com)
  • If you don't want to have to taste the fruit or consume the calories of a certain food, however, you can also purchase it as an acai berry capsule, or pill, where all the acai fruit's power is concentrated into an easy-to-swallow form. (selfgrowth.com)
  • Capsule endoscope will have a slippery coating, so it is easier to swallow. (medlineplus.gov)
  • Vancocin capsules contain the active ingredient vancomycin, which is a type of medicine called an antibiotic. (netdoctor.co.uk)
  • Gynoxin vaginal cream and vaginal capsules both contain the active ingredient fenticonazole, which is an antifungal medicine used to treat infections with fungi and yeasts. (netdoctor.co.uk)
  • FDA laboratory analysis confirmed that Control Capsules contain sildenafil, the active ingredient in the FDA-approved prescription drug Viagra, used to treat erectile dysfunction. (fda.gov)
  • FDA laboratory analysis confirmed that Salute Capsules contain sildenafil, thiosildenafil, and sulfoaildenafil. (fda.gov)
  • Spirulina capsules are a wonderful option for those seeking the healthful properties of spirulina without the algae flavor. (mountainroseherbs.com)
  • Examples: egg shell, articular capsules, renal capsules[WP]. (ebi.ac.uk)
  • Vancocin capsules can be taken either with or without food. (netdoctor.co.uk)
  • Note that FMA has classes such as Articular capsule that are not subtypes of Capsule (which is undefined in FMA). (ebi.ac.uk)
  • On the inside of the capsule, articular cartilage covers the end surfaces of the bones that articulate within that joint. (wikipedia.org)
  • The capsule that launched the first American into space more than 50 years ago will soon be moved from Maryland to Massachusetts, before ultimately landing in Washington, D.C. in 2016. (space.com)
  • 3-17-2016] The Food and Drug Administration (FDA) is advising consumers not to purchase or use Salute Capsules, a product promoted and sold for sexual enhancement on various websites and possibly in some retail stores. (fda.gov)
  • Photo source: Sandoz Sandoz is recalling all quantities and lots within of Ranitidine Hydrochloride Capsules in the US. (consumeraffairs.com)
  • Health Capsules was originally produced by Dr. Michael A. Petti and cartoonist Jud Hurd, beginning in 1961 until 2002, when it was taken over by Bron Smith. (wikipedia.org)
  • Fénix-2 capsule on display in front of La Moneda presidential palace in Santiago Fénix-2 capsule on display in Santiago in October 2010 Replica of the Fénix 2 capsule in Canberra Quecreek Mine Rescue involved a similar rescue capsule in Pennsylvania, July 2002 to rescue a trapped mining crew. (wikipedia.org)
  • Each capsule for oral administration, contains loxapine succinate, USP 6.8 mg, 13.6 mg, 34.0 mg or 68.1 mg equivalent to 5 mg, 10 mg, 25 mg or 50 mg of loxapine base respectively. (nih.gov)
  • Loxapine capsules are indicated for the treatment of schizophrenia. (nih.gov)
  • The capsule is the size of a large vitamin pill, about an inch (2.5 centimeters) long and less than ½ inch (1.3 centimeters) wide. (medlineplus.gov)
  • A Soyuz capsule carrying two Russians cosmonauts and a U.S. astronaut back on Earth after departing the International Space Station. (wsj.com)
  • Vancomycin Hydrochloride Capsules are indicated for the treatment of C. difficile- associated diarrhea (CDAD). (prnewswire.com)
  • Vancomycin Hydrochloride Capsules are also used for the treatment of enterocolitis caused by Staphylococcus aureus (including methicillin-resistant strains). (prnewswire.com)
  • Vancomycin Hydrochloride Capsules are contraindicated in patients who have experienced a hypersensitivity to vancomycin. (prnewswire.com)
  • Vancomycin Hydrochloride Capsules must be given orally for treatment of staphylococcal enterocolitis and CDAD. (prnewswire.com)
  • Orally administered Vancomycin Hydrochloride Capsules are not effective for other types of infections. (prnewswire.com)
  • Clinically significant serum concentrations have been reported in some patients who have taken multiple oral doses of Vancomycin Hydrochloride Capsules for active CDAD. (prnewswire.com)
  • Nephrotoxicity has occurred following oral Vancomycin Hydrochloride Capsules therapy and can occur either during or after completion of therapy. (prnewswire.com)
  • Ototoxicity has occurred in patients receiving Vancomycin Hydrochloride Capsules. (prnewswire.com)
  • Prescribing Vancomycin Hydrochloride Capsules in the absence of a proven or strongly suspected bacterial infection is unlikely to provide benefit to the patient and increases the risk of the development of drug resistant bacteria. (prnewswire.com)
  • Clinicians should be aware of the importance of appropriate duration of Vancomycin Hydrochloride Capsules treatment in patients over 65 years of age and not discontinue or switch to alternative treatment prematurely. (prnewswire.com)
  • Vancomycin Hydrochloride Capsules represent the latest product from Prasco in its Authorized Generics program. (prnewswire.com)
  • Serologic difference of the doxycycline capsules used treat exposure of adding thingdont to the cellular phenotype of tract for months with dose infant is detailed. (unionmusicaldebenidorm.com)
  • This gives us the capsule days including wide final and sales atopic tips grow and its dose to. (goorganics.us)
  • Plus, with capsules, you know how much peppermint oil you're getting with each dose. (webmd.com)
  • Gynoxin 200mg vaginal capsules are a three dose treatment. (netdoctor.co.uk)
  • Gynoxin 600mg vaginal capsule is a single dose treatment. (netdoctor.co.uk)
  • The capsule should be inserted into the vagina as a single dose at bedtime. (netdoctor.co.uk)
  • You will want to make sure that you are buying acai berry capsules that are primarily the fruit pulp and juice rather than filler or other additional items and you should check how many mg of actual fruit you are getting in each dose. (selfgrowth.com)
  • Nature's Reward Turmeric Curcumin Complex Capsules offer a daily dose of free radical-fighting antioxidants in a traditional herbal supplement. (bedbathandbeyond.com)
  • The capsule of a lymph node refers to the fibrous tissue which encloses the node. (innerbody.com)
  • Medication related microbial againscissors were next, and doxycycline capsules used treat not led to next-day of the check moisturizer. (unionmusicaldebenidorm.com)
  • Do that chew, 250mg capsule amoxil divide, or break allergic une sites and price lines. (goorganics.us)
  • The chimp was strapped into a retaining harness inside the capsule and had to operate a system of levers and lights to test its reactions to flight. (si.edu)
  • The Fénix capsules have a harness to hold the occupant, an oxygen supply, and a microphone with speakers, which were used to connect the miners with the rescuers at the surface during the rescue. (wikipedia.org)
  • Mind that good miners and capsule practitioners may moderately interact with the late periods with clomid trunk. (goorganics.us)
  • The Fénix capsules were three metallic containers that were used for the rescue of 33 trapped miners after the 2010 Copiapó mining accident, and are an enhanced version of the Dahlbusch Bomb. (wikipedia.org)
  • The senior valuer for auctioneers Dominic Winter in Gloucestershire, England said "The capsule is a 21st-century icon and symbolizes many things including the triumph of hope and the human spirit over adversity, teamwork and technology over nature and the myriad of uplifting stories of the 33 miners and their families. (wikipedia.org)
  • If your intestines are blocked or narrow, the capsule can get stuck. (medlineplus.gov)
  • There are very few problems that can occur with capsule endoscopy. (medlineplus.gov)
  • Moreover, the seamless material-filled capsules thus obtained by the apparatus of the present invention can occur as miniature capsules, namely, in the form of much smaller capsules than capsules obtained by a conventional apparatus. (google.com)
  • An autopsy the following day revealed she died from acute cyanide poisoning, but it was not until Monday night that toxicologists traced the poison to a bottle of Extra-Strength Excedrin capsules in her home, the medical examiner's office said. (upi.com)
  • The Food and Drug Administration reported Monday night that 'several capsules' in a 60-capsule bottle of Extra-Strength Excedrin found in the Snow's home were laced with cyanide. (upi.com)
  • The bottle containing the poisoned capsules was believed to have been purchased from a store in Auburn June 8 or 9, police said. (upi.com)
  • The Tylenol scare resurfaced four years later after Diane Elsroth, 23, of Peekskill, N.Y., died Feb. 8 from taking two Extra-Strength Tylenol capsules from a bottle purchased in an A&P store in Bronxville. (upi.com)
  • On Feb. 13, a second bottle of poisoned Tylenol was found in a Woolworth's store in Bronxville, and four days later, Johnson & Johnson, the makers of Tylenol, announced it had halted production of all non-prescription capsule drugs. (upi.com)
  • Besides being used for butterfly of a treat used capsules doxycycline observational function of canadas, dog is also used as doxycycline okviru breathing in alternative possible anaerobes and as trachomatistest-of-cure in herbal drugs. (unionmusicaldebenidorm.com)
  • BEIJING-China's drug regulator suspended the sale of 13 drugs using capsules allegedly made with excessive chromium levels, highlighting China's continued battle with food and drug safety as well as what analysts say are mounting cost pressures amid the government's health-care overhaul. (wsj.com)
  • After the capsule is swallowed, stomach acid dissolves the outer layer of the capsule, and the six arms unfold. (medicinenet.com)
  • A number of plants disperse their seeds in a rather artistic way: the seed capsules of the ice plant Delosperma nakurense , for instance, unfold lids over the seed compartments in the manner of a movable origami when they are moistened by rain. (mpg.de)
  • In addition, Auburn police were asking any consumers with bottles of Extra-Strength Excedrin bearing the same lot number as the tainted capsules to bring the capsules to police. (upi.com)
  • The first rash of killings in the United States from poisoned painkillers occurred in 1982 when seven people died from taking cyanide-laced capsules of Extra-Strength Tylenol that had been planted on Chicago-area markets. (upi.com)
  • Within the otic capsule are the usual labyrinthine endings, including an auditory papilla. (britannica.com)
  • The auditory papilla lies in a path between the oval window and an opening (the round window) in the posterior wall of the otic capsule . (britannica.com)
  • Freedom 7 Mercury Capsule, Flown by 1st American in Space, Heads to Boston, D.C. (space.com)
  • The National Air and Space Museum is working on a long range plan for exhibiting the Mercury Freedom 7 capsule," the museum explained in a statement. (space.com)
  • The Air and Space Museum currently displays Friendship 7, the Mercury capsule that launched John Glenn on the United States' first orbital mission in February 1962, in its "Milestones of Flight" gallery. (space.com)
  • The museum's annex, the Steven F. Udvar-Hazy Center in Virginia, has "Freedom 7 II," the Mercury capsule that Shepard had hoped to fly for his second flight before the mission was canceled. (space.com)
  • The coating keeps your stomach juices from breaking down the capsules. (webmd.com)
  • Traverso said the capsule dissolves, and the star won't move from the stomach and block the intestinal tract. (medicinenet.com)
  • This invention relates to an apparatus for manufacturing seamless material-filled capsules, and miniature capsules having the values of particle diameter 0.5-4 mm, weight 1-30 mg, film percentage 5-30% and film thickness 0.05-0.2 mm. (google.com)
  • The Fénix 1 had a larger diameter than the other two capsules and was used in tests in the shaft created by the Schramm Inc. T-130 drill, where it descended to a depth of 610 metres (2,000 ft). (wikipedia.org)