Capsules: Hard or soft soluble containers used for the oral administration of medicine.Bacterial Capsules: An envelope of loose gel surrounding a bacterial cell which is associated with the virulence of pathogenic bacteria. Some capsules have a well-defined border, whereas others form a slime layer that trails off into the medium. Most capsules consist of relatively simple polysaccharides but there are some bacteria whose capsules are made of polypeptides.Capsule Endoscopy: Non-invasive, endoscopic imaging by use of VIDEO CAPSULE ENDOSCOPES to perform examination of the gastrointestinal tract, especially the small bowel.Joint Capsule: The sac enclosing a joint. It is composed of an outer fibrous articular capsule and an inner SYNOVIAL MEMBRANE.Lens Capsule, Crystalline: The thin noncellular outer covering of the CRYSTALLINE LENS composed mainly of COLLAGEN TYPE IV and GLYCOSAMINOGLYCANS. It is secreted by the embryonic anterior and posterior epithelium. The embryonic posterior epithelium later disappears.Capsule Endoscopes: A pill sized videocamera encased in a capsule. It is designed to be swallowed and subsequently traverse the gastrointestinal tract while transmitting diagnostic images along the way.Internal Capsule: WHITE MATTER pathway, flanked by nuclear masses, consisting of both afferent and efferent fibers projecting between the WHITE MATTER and the BRAINSTEM. It consists of three distinct parts: an anterior limb, posterior limb, and genu.Fungal Capsules: An extracellular layer outside the cell wall of a fungus composed of polysaccharides. It may serve a protective role amongst others.Bowman Capsule: A double-walled epithelial capsule that is the bulbous closed proximal end of the kidney tubular system. It surrounds the cluster of convoluted capillaries of KIDNEY GLOMERULUS and is continuous with the convoluted PROXIMAL KIDNEY TUBULE.Subrenal Capsule Assay: In vivo method of screening investigative anticancer drugs and biologic response modifiers for individual cancer patients. Fresh tumor tissue is implanted under the kidney capsule of immunocompetent mice or rats; gross and histological assessments follow several days after tumor treatment in situ.Polysaccharides, Bacterial: Polysaccharides found in bacteria and in capsules thereof.Capsule Opacification: Clouding or loss of transparency of the posterior lens capsule, usually following CATARACT extraction.Posterior Capsule of the Lens: The posterior aspect of the casing that surrounds the natural CRYSTALLINE LENS.Cryptococcus neoformans: A species of the fungus CRYPTOCOCCUS. Its teleomorph is Filobasidiella neoformans.Lens DiseasesCapsulorhexis: The making of a continuous circular tear in the anterior capsule during cataract surgery in order to allow expression or phacoemulsification of the nucleus of the lens. (Dorland, 28th ed)Lens, Crystalline: A transparent, biconvex structure of the EYE, enclosed in a capsule and situated behind the IRIS and in front of the vitreous humor (VITREOUS BODY). It is slightly overlapped at its margin by the ciliary processes. Adaptation by the CILIARY BODY is crucial for OCULAR ACCOMMODATION.Anterior Capsule of the Lens: The anterior aspect of the casing that surrounds the natural CRYSTALLINE LENS.Endoscopes, Gastrointestinal: Instruments for the visual examination of the interior of the gastrointestinal tract.PolysaccharidesVirulence: The degree of pathogenicity within a group or species of microorganisms or viruses as indicated by case fatality rates and/or the ability of the organism to invade the tissues of the host. The pathogenic capacity of an organism is determined by its VIRULENCE FACTORS.Drugs, Chinese Herbal: Chinese herbal or plant extracts which are used as drugs to treat diseases or promote general well-being. The concept does not include synthesized compounds manufactured in China.Endoscopy, Gastrointestinal: Endoscopic examination, therapy or surgery of the gastrointestinal tract.Intestinal Diseases: Pathological processes in any segment of the INTESTINE from DUODENUM to RECTUM.Gastrointestinal Hemorrhage: Bleeding in any segment of the GASTROINTESTINAL TRACT from ESOPHAGUS to RECTUM.Contracture: Prolonged shortening of the muscle or other soft tissue around a joint, preventing movement of the joint.Phacoemulsification: A procedure for removal of the crystalline lens in cataract surgery in which an anterior capsulectomy is performed by means of a needle inserted through a small incision at the temporal limbus, allowing the lens contents to fall through the dilated pupil into the anterior chamber where they are broken up by the use of ultrasound and aspirated out of the eye through the incision. (Cline, et al., Dictionary of Visual Science, 4th ed & In Focus 1993;1(1):1)Intestine, Small: The portion of the GASTROINTESTINAL TRACT between the PYLORUS of the STOMACH and the ILEOCECAL VALVE of the LARGE INTESTINE. It is divisible into three portions: the DUODENUM, the JEJUNUM, and the ILEUM.Tablets, Enteric-Coated: Tablets coated with material that delays release of the medication until after they leave the stomach. (Dorland, 28th ed)Cataract: Partial or complete opacity on or in the lens or capsule of one or both eyes, impairing vision or causing blindness. The many kinds of cataract are classified by their morphology (size, shape, location) or etiology (cause and time of occurrence). (Dorland, 27th ed)Cryptococcosis: Infection with a fungus of the species CRYPTOCOCCUS NEOFORMANS.Joint Capsule Release: Surgical procedure to relax the JOINT CAPSULE tissues in a joint that has a reduced range of motion due to CONTRACTURE or TISSUE ADHESIONS or joint deformities.Delayed-Action Preparations: Dosage forms of a drug that act over a period of time by controlled-release processes or technology.Cataract Extraction: The removal of a cataractous CRYSTALLINE LENS from the eye.Tablets: Solid dosage forms, of varying weight, size, and shape, which may be molded or compressed, and which contain a medicinal substance in pure or diluted form. (Dorland, 28th ed)Foreign-Body Reaction: Chronic inflammation and granuloma formation around irritating foreign bodies.Lenses, Intraocular: Artificial implanted lenses.Streptococcus pneumoniae: A gram-positive organism found in the upper respiratory tract, inflammatory exudates, and various body fluids of normal and/or diseased humans and, rarely, domestic animals.Molteno Implants: Devices implanted to control intraocular pressure by allowing aqueous fluid to drain from the anterior chamber. (Hoffman, Pocket Glossary of Ophthalmologic Terminology, 1989)Uridine Diphosphate Glucose Dehydrogenase: An enzyme that catalyzes the oxidation of UDPglucose to UDPglucuronate in the presence of NAD+. EC Proteins: Proteins found in any species of bacterium.Chemistry, Pharmaceutical: Chemistry dealing with the composition and preparation of agents having PHARMACOLOGIC ACTIONS or diagnostic use.Polyglutamic Acid: A peptide that is a homopolymer of glutamic acid.Administration, Oral: The giving of drugs, chemicals, or other substances by mouth.Bacillus anthracis: A species of bacteria that causes ANTHRAX in humans and animals.Lens Implantation, Intraocular: Insertion of an artificial lens to replace the natural CRYSTALLINE LENS after CATARACT EXTRACTION or to supplement the natural lens which is left in place.Gastrointestinal Transit: Passage of food (sometimes in the form of a test meal) through the gastrointestinal tract as measured in minutes or hours. The rate of passage through the intestine is an indicator of small bowel function.Drug Compounding: The preparation, mixing, and assembling of a drug. (From Remington, The Science and Practice of Pharmacy, 19th ed, p1814)Islets of Langerhans Transplantation: The transference of pancreatic islets within an individual, between individuals of the same species, or between individuals of different species.Silicone Elastomers: Polymers of silicone that are formed by crosslinking and treatment with amorphous silica to increase strength. They have properties similar to vulcanized natural rubber, in that they stretch under tension, retract rapidly, and fully recover to their original dimensions upon release. They are used in the encapsulation of surgical membranes and implants.Serotyping: Process of determining and distinguishing species of bacteria or viruses based on antigens they share.Double-Blind Method: A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.Cryptococcus: A mitosporic Tremellales fungal genus whose species usually have a capsule and do not form pseudomycellium. Teleomorphs include Filobasidiella and Fidobasidium.Biological Availability: The extent to which the active ingredient of a drug dosage form becomes available at the site of drug action or in a biological medium believed to reflect accessibility to a site of action.Microscopy, Electron: Microscopy using an electron beam, instead of light, to visualize the sample, thereby allowing much greater magnification. The interactions of ELECTRONS with specimens are used to provide information about the fine structure of that specimen. In TRANSMISSION ELECTRON MICROSCOPY the reactions of the electrons that are transmitted through the specimen are imaged. In SCANNING ELECTRON MICROSCOPY an electron beam falls at a non-normal angle on the specimen and the image is derived from the reactions occurring above the plane of the specimen.Neisseria meningitidis: A species of gram-negative, aerobic BACTERIA. It is a commensal and pathogen only of humans, and can be carried asymptomatically in the NASOPHARYNX. When found in cerebrospinal fluid it is the causative agent of cerebrospinal meningitis (MENINGITIS, MENINGOCOCCAL). It is also found in venereal discharges and blood. There are at least 13 serogroups based on antigenic differences in the capsular polysaccharides; the ones causing most meningitis infections being A, B, C, Y, and W-135. Each serogroup can be further classified by serotype, serosubtype, and immunotype.Glycosyltransferases: Enzymes that catalyze the transfer of glycosyl groups to an acceptor. Most often another carbohydrate molecule acts as an acceptor, but inorganic phosphate can also act as an acceptor, such as in the case of PHOSPHORYLASES. Some of the enzymes in this group also catalyze hydrolysis, which can be regarded as transfer of a glycosyl group from the donor to water. Subclasses include the HEXOSYLTRANSFERASES; PENTOSYLTRANSFERASES; SIALYLTRANSFERASES; and those transferring other glycosyl groups. EC 2.4.Genes, Bacterial: The functional hereditary units of BACTERIA.Silicones: A broad family of synthetic organosiloxane polymers containing a repeating silicon-oxygen backbone with organic side groups attached via carbon-silicon bonds. Depending on their structure, they are classified as liquids, gels, and elastomers. (From Merck Index, 12th ed)Jejunal Diseases: Pathological development in the JEJUNUM region of the SMALL INTESTINE.Double-Balloon Enteroscopy: Endoscopy of the small intestines accomplished while advancing the endoscope into the intestines from the stomach by alternating the inflation of two balloons, one on an innertube of the endoscope and the other on an overtube.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Phagocytosis: The engulfing and degradation of microorganisms; other cells that are dead, dying, or pathogenic; and foreign particles by phagocytic cells (PHAGOCYTES).Virulence Factors: Those components of an organism that determine its capacity to cause disease but are not required for its viability per se. Two classes have been characterized: TOXINS, BIOLOGICAL and surface adhesion molecules that effect the ability of the microorganism to invade and colonize a host. (From Davis et al., Microbiology, 4th ed. p486)Hexuronic Acids: Term used to designate tetrahydroxy aldehydic acids obtained by oxidation of hexose sugars, i.e. glucuronic acid, galacturonic acid, etc. Historically, the name hexuronic acid was originally given to ascorbic acid.Dosage Forms: Completed forms of the pharmaceutical preparation in which prescribed doses of medication are included. They are designed to resist action by gastric fluids, prevent vomiting and nausea, reduce or alleviate the undesirable taste and smells associated with oral administration, achieve a high concentration of drug at target site, or produce a delayed or long-acting drug effect.Escherichia coli: A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.Alginates: Salts of alginic acid that are extracted from marine kelp and used to make dental impressions and as absorbent material for surgical dressings.Blood Bactericidal Activity: The natural bactericidal property of BLOOD due to normally occurring antibacterial substances such as beta lysin, leukin, etc. This activity needs to be distinguished from the bactericidal activity contained in a patient's serum as a result of antimicrobial therapy, which is measured by a SERUM BACTERICIDAL TEST.Antigens, Bacterial: Substances elaborated by bacteria that have antigenic activity.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Anisotropy: A physical property showing different values in relation to the direction in or along which the measurement is made. The physical property may be with regard to thermal or electric conductivity or light refraction. In crystallography, it describes crystals whose index of refraction varies with the direction of the incident light. It is also called acolotropy and colotropy. The opposite of anisotropy is isotropy wherein the same values characterize the object when measured along axes in all directions.Anthrax: An acute infection caused by the spore-forming bacteria BACILLUS ANTHRACIS. It commonly affects hoofed animals such as sheep and goats. Infection in humans often involves the skin (cutaneous anthrax), the lungs (inhalation anthrax), or the gastrointestinal tract. Anthrax is not contagious and can be treated with antibiotics.Microscopy, Electron, Scanning: Microscopy in which the object is examined directly by an electron beam scanning the specimen point-by-point. The image is constructed by detecting the products of specimen interactions that are projected above the plane of the sample, such as backscattered electrons. Although SCANNING TRANSMISSION ELECTRON MICROSCOPY also scans the specimen point by point with the electron beam, the image is constructed by detecting the electrons, or their interaction products that are transmitted through the sample plane, so that is a form of TRANSMISSION ELECTRON MICROSCOPY.Connective Tissue: Tissue that supports and binds other tissues. It consists of CONNECTIVE TISSUE CELLS embedded in a large amount of EXTRACELLULAR MATRIX.Basement Membrane: A darkly stained mat-like EXTRACELLULAR MATRIX (ECM) that separates cell layers, such as EPITHELIUM from ENDOTHELIUM or a layer of CONNECTIVE TISSUE. The ECM layer that supports an overlying EPITHELIUM or ENDOTHELIUM is called basal lamina. Basement membrane (BM) can be formed by the fusion of either two adjacent basal laminae or a basal lamina with an adjacent reticular lamina of connective tissue. BM, composed mainly of TYPE IV COLLAGEN; glycoprotein LAMININ; and PROTEOGLYCAN, provides barriers as well as channels between interacting cell layers.Gene Expression Regulation, Bacterial: Any of the processes by which cytoplasmic or intercellular factors influence the differential control of gene action in bacteria.Cross-Over Studies: Studies comparing two or more treatments or interventions in which the subjects or patients, upon completion of the course of one treatment, are switched to another. In the case of two treatments, A and B, half the subjects are randomly allocated to receive these in the order A, B and half to receive them in the order B, A. A criticism of this design is that effects of the first treatment may carry over into the period when the second is given. (Last, A Dictionary of Epidemiology, 2d ed)Sialic Acids: A group of naturally occurring N-and O-acyl derivatives of the deoxyamino sugar neuraminic acid. They are ubiquitously distributed in many tissues.O Antigens: The lipopolysaccharide-protein somatic antigens, usually from gram-negative bacteria, important in the serological classification of enteric bacilli. The O-specific chains determine the specificity of the O antigens of a given serotype. O antigens are the immunodominant part of the lipopolysaccharide molecule in the intact bacterial cell. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)Excipients: Usually inert substances added to a prescription in order to provide suitable consistency to the dosage form. These include binders, matrix, base or diluent in pills, tablets, creams, salves, etc.Glucuronic Acid: A sugar acid formed by the oxidation of the C-6 carbon of GLUCOSE. In addition to being a key intermediate metabolite of the uronic acid pathway, glucuronic acid also plays a role in the detoxification of certain drugs and toxins by conjugating with them to form GLUCURONIDES.Telemetry: Transmission of the readings of instruments to a remote location by means of wires, radio waves, or other means. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Bacterial Adhesion: Physicochemical property of fimbriated (FIMBRIAE, BACTERIAL) and non-fimbriated bacteria of attaching to cells, tissue, and nonbiological surfaces. It is a factor in bacterial colonization and pathogenicity.Ligaments: Shiny, flexible bands of fibrous tissue connecting together articular extremities of bones. They are pliant, tough, and inextensile.Dietary Supplements: Products in capsule, tablet or liquid form that provide dietary ingredients, and that are intended to be taken by mouth to increase the intake of nutrients. Dietary supplements can include macronutrients, such as proteins, carbohydrates, and fats; and/or MICRONUTRIENTS, such as VITAMINS; MINERALS; and PHYTOCHEMICALS.UDPglucose 4-Epimerase: A necessary enzyme in the metabolism of galactose. It reversibly catalyzes the conversion of UDPglucose to UDPgalactose. NAD+ is an essential component for enzymatic activity. EC Acid: A natural high-viscosity mucopolysaccharide with alternating beta (1-3) glucuronide and beta (1-4) glucosaminidic bonds. It is found in the UMBILICAL CORD, in VITREOUS BODY and in SYNOVIAL FLUID. A high urinary level is found in PROGERIA.Rabbits: The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.Streptococcus pyogenes: A species of gram-positive, coccoid bacteria isolated from skin lesions, blood, inflammatory exudates, and the upper respiratory tract of humans. It is a group A hemolytic Streptococcus that can cause SCARLET FEVER and RHEUMATIC FEVER.Angiodysplasia: Acquired degenerative dilation or expansion (ectasia) of normal BLOOD VESSELS, often associated with aging. They are isolated, tortuous, thin-walled vessels and sources of bleeding. They occur most often in mucosal capillaries of the GASTROINTESTINAL TRACT leading to GASTROINTESTINAL HEMORRHAGE and ANEMIA.Klebsiella pneumoniae: Gram-negative, non-motile, capsulated, gas-producing rods found widely in nature and associated with urinary and respiratory infections in humans.Phytotherapy: Use of plants or herbs to treat diseases or to alleviate pain.Drug Implants: Small containers or pellets of a solid drug implanted in the body to achieve sustained release of the drug.N-Acetylneuraminic Acid: An N-acyl derivative of neuraminic acid. N-acetylneuraminic acid occurs in many polysaccharides, glycoproteins, and glycolipids in animals and bacteria. (From Dorland, 28th ed, p1518)Immunohistochemistry: Histochemical localization of immunoreactive substances using labeled antibodies as reagents.Gelatin: A product formed from skin, white connective tissue, or bone COLLAGEN. It is used as a protein food adjuvant, plasma substitute, hemostatic, suspending agent in pharmaceutical preparations, and in the manufacturing of capsules and suppositories.Polymethyl Methacrylate: Polymerized methyl methacrylate monomers which are used as sheets, moulding, extrusion powders, surface coating resins, emulsion polymers, fibers, inks, and films (From International Labor Organization, 1983). This material is also used in tooth implants, bone cements, and hard corneal contact lenses.Acrylic ResinsEpithelial Cells: Cells that line the inner and outer surfaces of the body by forming cellular layers (EPITHELIUM) or masses. Epithelial cells lining the SKIN; the MOUTH; the NOSE; and the ANAL CANAL derive from ectoderm; those lining the RESPIRATORY SYSTEM and the DIGESTIVE SYSTEM derive from endoderm; others (CARDIOVASCULAR SYSTEM and LYMPHATIC SYSTEM) derive from mesoderm. Epithelial cells can be classified mainly by cell shape and function into squamous, glandular and transitional epithelial cells.Methylcellulose: Methylester of cellulose. Methylcellulose is used as an emulsifying and suspending agent in cosmetics, pharmaceutics and the chemical industry. It is used therapeutically as a bulk laxative.Nerve Fibers, Myelinated: A class of nerve fibers as defined by their structure, specifically the nerve sheath arrangement. The AXONS of the myelinated nerve fibers are completely encased in a MYELIN SHEATH. They are fibers of relatively large and varied diameters. Their NEURAL CONDUCTION rates are faster than those of the unmyelinated nerve fibers (NERVE FIBERS, UNMYELINATED). Myelinated nerve fibers are present in somatic and autonomic nerves.Pasteurella multocida: A species of gram-negative, facultatively anaerobic, rod-shaped bacteria normally found in the flora of the mouth and respiratory tract of animals and birds. It causes shipping fever (see PASTEURELLOSIS, PNEUMONIC); HEMORRHAGIC BACTEREMIA; and intestinal disease in animals. In humans, disease usually arises from a wound infection following a bite or scratch from domesticated animals.Cell Wall: The outermost layer of a cell in most PLANTS; BACTERIA; FUNGI; and ALGAE. The cell wall is usually a rigid structure that lies external to the CELL MEMBRANE, and provides a protective barrier against physical or chemical agents.Disease Models, Animal: Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.Kidney: Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.Temporal Bone: Either of a pair of compound bones forming the lateral (left and right) surfaces and base of the skull which contains the organs of hearing. It is a large bone formed by the fusion of parts: the squamous (the flattened anterior-superior part), the tympanic (the curved anterior-inferior part), the mastoid (the irregular posterior portion), and the petrous (the part at the base of the skull).Mutation: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.Diffusion Tensor Imaging: The use of diffusion ANISOTROPY data from diffusion magnetic resonance imaging results to construct images based on the direction of the faster diffusing molecules.Diffusion Magnetic Resonance Imaging: A diagnostic technique that incorporates the measurement of molecular diffusion (such as water or metabolites) for tissue assessment by MRI. The degree of molecular movement can be measured by changes of apparent diffusion coefficient (ADC) with time, as reflected by tissue microstructure. Diffusion MRI has been used to study BRAIN ISCHEMIA and tumor response to treatment.Powders: Substances made up of an aggregation of small particles, as that obtained by grinding or trituration of a solid drug. In pharmacy it is a form in which substances are administered. (From Dorland, 28th ed)Hydrodynamics: The motion of fluids, especially noncompressible liquids, under the influence of internal and external forces.Collagen: A polypeptide substance comprising about one third of the total protein in mammalian organisms. It is the main constituent of SKIN; CONNECTIVE TISSUE; and the organic substance of bones (BONE AND BONES) and teeth (TOOTH).Transplantation, Heterotopic: Transplantation of tissue typical of one area to a different recipient site. The tissue may be autologous, heterologous, or homologous.Cathartics: Agents that are used to stimulate evacuation of the bowels.Mutagenesis, Insertional: Mutagenesis where the mutation is caused by the introduction of foreign DNA sequences into a gene or extragenic sequence. This may occur spontaneously in vivo or be experimentally induced in vivo or in vitro. Proviral DNA insertions into or adjacent to a cellular proto-oncogene can interrupt GENETIC TRANSLATION of the coding sequences or interfere with recognition of regulatory elements and cause unregulated expression of the proto-oncogene resulting in tumor formation.Suspensions: Colloids with liquid continuous phase and solid dispersed phase; the term is used loosely also for solid-in-gas (AEROSOLS) and other colloidal systems; water-insoluble drugs may be given as suspensions.

Cephalosporin and aminoglycoside concentrations in peritoneal capsular fluid in rabbits. (1/735)

To study the penetration of antibiotics into peritoneal tissue fluid, a subcutaneous tissue capsule model was modified by implanting multiple, perforated spherical capsules in the peritoneal cavity of rabbits. Capsules became vascularized, encased in connective tissue, and filled with fluid having a mean protein concentration of 3.6 g/100 ml. Capsular fluid was obtained by percutaneous needle aspiration and assayed for antibiotic by the disk plate bioassay technique. Cephalosporins were administered intramuscularly at a dose of 30 mg/kg. Mean peak concentrations of cephaloridine and cefazolin were significantly higher than cephalothin and cephapirin in capsular fluids, but the percent penetration (ratio of capsular mean peak to serum mean peak) ranged from 8.7 to 16.9% and was not significantly different among the cephalosporins. At 24 h the capsular concentration of cefazolin was significantly greater than for the other cephalosporins (P < 0.001). Lower rabbit serum protein binding observed at high in vivo concentrations may have enabled cefazolin to penetrate capsular fluid, but in vitro protein binding studies did not confirm a decrease in serum protein binding at high concentrations within the clinical range. Kanamycin and amikacin showed comparable capsular fluid peak concentrations as did gentamicin and tobramycin. The percent penetration ranged from 15.2 to 34.5% for the aminoglycosides. The only statistical difference was that amikacin penetration was significantly higher than that for tobramycin. Mean capsular concentrations of amikacin, cefazolin, and cephaloridine compared most favorably with the minimum inhibitory concentration of gram-negative bacilli at the dosages used in this study.  (+info)

A cortisol suppression dose-response comparison of budesonide in controlled ileal release capsules with prednisolone. (2/735)

AIM: To assess the systemic effect of oral budesonide, given as Entocort controlled ileal release capsules, over a dose range of 3-15 mg/day, compared with that of a moderate dose (20 mg/day) of prednisolone. METHODS: Twenty four healthy subjects were given 3, 9 or 15 mg budesonide or 20 mg prednisolone once daily, or 4.5 mg budesonide b.d., or placebo for 5 days in a randomized, double-blind crossover study. The area under the curve (AUC) of plasma cortisol concentration and the amount of cortisol excreted in the urine were monitored. RESULTS: Both plasma and urine cortisol suppression showed a dose-response for the daily doses of budesonide. Prednisolone, 20 mg, suppressed plasma cortisol (AUC) statistically significantly more than 15 mg budesonide (P = 0.014), and 3 mg budesonide statistically significantly more than placebo (P = 0.010). No difference in AUC was detected between 9 mg and 4.5 mg budesonide b.d. Similar results for budesonide vs. placebo were obtained from urine cortisol excretion data. However, prednisolone affected urine cortisol less than it affected plasma cortisol. CONCLUSION: After 5 days of administration, budesonide controlled ileal release capsules, in both clinical (9 mg/day) and high doses (15 mg/day), affected plasma cortisol less than a moderate (20 mg/day) dose of prednisolone.  (+info)

Breast milk immune factors in Bangladeshi women supplemented postpartum with retinol or beta-carotene. (3/735)

BACKGROUND: Vitamin A supplementation of mothers postpartum may improve infant health, not only by increasing vitamin A delivery to the infant through breast milk but also by increasing delivery of milk immune factors. Our hypothesis was that postpartum supplementation with vitamin A increases milk concentrations of certain soluble immune factors. DESIGN: In a double-blind trial conducted in Matlab, Bangladesh, women at 1-3 wk postpartum were randomly assigned to receive until 9 mo postpartum 1) a single dose of 60 mg retinol as retinyl palmitate followed by daily placebos (n = 69), 2) daily doses of 7.6 mg beta-carotene (n = 72), or 3) daily placebos (n = 71). Milk samples collected at baseline and 3 mo postpartum were analyzed by enzyme-linked immunosorbent assay for secretory immunoglobulin A, lactoferrin, lysozyme, and interleukin 8; by HPLC for total retinol; and by atomic absorption spectroscopy for sodium and potassium. RESULTS: After mammary epithelial permeability (defined as an elevated Na:K) and baseline immune factor concentrations were controlled for, there were no significant treatment effects on immune factors at 3 mo. Increased mammary permeability was common (25% of women at baseline and 12% at 3 mo) and was associated with higher concentrations of milk immune factors. Low body vitamin A stores at baseline, as assessed by the modified-relative-dose-response test, were associated with a higher Na:K, but neither retinol nor beta-carotene supplementation affected the prevalence of increased mammary permeability. CONCLUSIONS: Postpartum vitamin A supplementation does not increase milk concentrations of immune factors. The causes of increased mammary epithelial permeability in this population require further study.  (+info)

Continuous delivery of human and mouse erythropoietin in mice by genetically engineered polymer encapsulated myoblasts. (4/735)

The transplantation of polymer encapsulated myoblasts genetically engineered to secrete erythropoietin (Epo) may obviate the need for repeated parenteral administration of recombinant Epo as a treatment for chronic renal failure, cancer or AIDS-associated anemia. To explore this possibility, the human and mouse Epo cDNAs under the control of the housekeeping mouse PGK-1 promoter were transfected into mouse C2C12 myoblasts, which can be terminally differentiated upon exposure to low serum-containing media. Pools releasing 150 IU human Epo per 10(6) cells per day and 390 IU mouse Epo per 10(6) cells per day were selected. Polyether-sulfone (PES) capsules loaded with approximately 200,000 transfected myoblasts from these pools were implanted on the dorsal flank of DBA/2J, C3H and C57BL/6 mice. With human Epo secreting capsules, only a transient increase in the hematocrit occurred in DBA/2J mice, whereas no significant response was detected in C3H or C57BL/6 mice. On the contrary, all mice implanted with capsules releasing mouse Epo increased their hematocrit over 85% as early as 7 days after implantation and sustained these levels for at least 80 days. All retrieved implants released Epo and contained well preserved myoblasts. Moreover most capsules were surrounded by a neovascularization. Mice transplanted with nonencapsulated C2C12 cells releasing mouse Epo showed only a transitory elevation of their hematocrit reflecting the poor engraftment of injected myoblasts. These results indicate that polymer encapsulation of genetically engineered myoblasts is a promising approach for the long-term delivery of bioactive molecules, allowing the resolution of the shortcomings of free myoblast transfer.  (+info)

Targeted chemotherapy by intratumour injection of encapsulated cells engineered to produce CYP2B1, an ifosfamide activating cytochrome P450. (5/735)

The prognosis of pancreatic adenocarcinoma is poor and current treatment ineffective. A novel treatment strategy is described here using a mouse model system for pancreatic cancer. Cells that have been genetically modified to express the cytochrome P450 2B1 enzyme are encapsulated in cellulose sulphate and implanted into pre-established tumours derived from human pancreatic cells. Cytochrome P450 2B1 converts the chemotherapeutic agent ifosfamide to toxic metabolites. Administration of ifosfamide to tumour-bearing mice that were recipients of implanted encapsulated cells results in partial or even complete tumour ablation. These results suggest that in situ chemotherapy with genetically modified cells in an immunoprotected environment may prove useful for application in man.  (+info)

Comparison of antiplatelet activity of microencapsulated aspirin 162.5 Mg (Caspac XL), with enteric coated aspirin 75 mg and 150 mg in patients with atherosclerosis. (6/735)

AIMS: A new formulation, low dose microencapsulated aspirin, permits slow absorption of aspirin and presystemic acetylation of platelet cyclo-oxygenase within the portal circulation, potentially avoiding deleterious effects on gastric and systemic prostaglandin synthesis. The objective of this study was to determine whether the administration of microencapsulated aspirin was as effective as enteric coated (EC) aspirin as an inhibitor of platelet function in patients with atherosclerosis. METHODS: One hundred and four patients were enrolled and randomised after a run in period of at least 14 days on aspirin EC 75 mg (day 0), to receive either microencapsulated aspirin 162.5 mg (n=34), aspirin EC 150 mg (n=36) or continue on aspirin EC 75 mg (n=34) for 28 days. Serum thromboxane B2 and collagen-induced platelet aggregation and release of 5-hydroxytryptamine (EC50 values) were measured on days 0 and 28. Aggregation/release EC50s were then repeated in the presence of a large dose of aspirin added in vitro to determine the EC50 at the maximum level of platelet inhibition. RESULTS: Median thromboxane B2 levels were low after 14 days run-in therapy with aspirin EC 75 mg, but significant further reductions were seen on day 28 in patients randomised to microencapsulated aspirin 162.5 mg (P=0.0368) and aspirin EC 150 mg (P=0.0004) compared with those remaining on aspirin EC 75 mg. Median EC50 s on day 28 showed small but significant increases from baseline (day 0) in aggregation in patients randomised to microencapsulated aspirin 162.5 mg (0.62-0.85, P=0.0482) and in both aggregation and release in patients randomised to aspirin EC 150 mg (0.95-1.20, P=0.0002, 8.4-11.7, P<0. 0001, respectively) signifying enhanced antiplatelet activity. No changes were seen in patients continuing on aspirin EC 75 mg. Results following addition of high dose aspirin in vitro suggest that mechanisms other than thromboxane synthesis may be operative in the long term effects of microencapsulated aspirin 162.5 mg and aspirin EC 150 mg over aspirin EC 75 mg. CONCLUSIONS: The results show good inhibition of thromboxane B2 synthesis and subsequent platelet activity by all preparations of aspirin, although both microencapsulated aspirin 162.5 mg and aspirin EC 150 mg are slightly more effective than aspirin EC 75 mg. A randomised trial is now required to determine whether microencapsulated aspirin is associated with fewer gastric side-effects.  (+info)

Improvement of mouse beta-thalassemia upon erythropoietin delivery by encapsulated myoblasts. (7/735)

The goal of the present study was to analyze if sustained delivery of elevated doses of recombinant erythropoietin (Epo), by genetically modified and immunoprotected allogenic cells, was able to correct the chronic anemia, characteristic of a spontaneous mouse model of beta-thalassemia (Hbb thal 1). Mouse C2C12 myoblast cells were transfected with a plasmid containing the mouse Epo cDNA and a mutated dihydrofolate reductase (DHFR) gene for gene amplification upon administration of increasing doses of methotrexate. In order to immunoprotect the transplanted cells, the stably modified cells were loaded into polyethersulfone microporus hollow fibers which were implanted subcutaneously into Hbb thal 1 mice. An increase in hematocrit starting 2 weeks after implantation was associated with elevated blood levels of Epo and an improved red blood cell phenotype. The latter indicated an improvement of cell morphology and membrane defects, in particular a reduced amount of free alpha hemoglobin chain, the hallmark of globin chain imbalance in beta-thalassemia. A reduction of reticulocyte count contrasting with the increase in hematocrit was also observed suggesting an improved erythrocyte survival. We conclude that the phenotype can be durably improved in some beta-thalassemic mice upon in vivo delivery of recombinant Epo by polymer encapsulated cells. Sustained elevated delivery of recombinant Epo holds promise for the treatment of beta-thalassemia-associated chronic anemia.  (+info)

Stabilized plasmid-lipid particles: construction and characterization. (8/735)

A detergent dialysis procedure is described which allows encapsulation of plasmid DNA within a lipid envelope, where the resulting particle is stabilized in aqueous media by the presence of a poly(ethyleneglycol) (PEG) coating. These 'stabilized plasmid-lipid particles' (SPLP) exhibit an average size of 70 nm in diameter, contain one plasmid per particle and fully protect the encapsulated plasmid from digestion by serum nucleases and E. coli DNase I. Encapsulation is a sensitive function of cationic lipid content, with maximum entrapment observed at dioleoyldimethylammonium chloride (DODAC) contents of 5 to 10 mol%. The formulation process results in plasmid-trapping efficiencies of up to 70% and permits inclusion of 'fusigenic' lipids such as dioleoylphosphatidylethanolamine (DOPE). The in vitro transfection capabilities of SPLP are demonstrated to be strongly dependent on the length of the acyl chain contained in the ceramide group used to anchor the PEG polymer to the surface of the SPLP. Shorter acyl chain lengths result in a PEG coating which can dissociate from the SPLP surface, transforming the SPLP from a stable particle to a transfection-competent entity. It is suggested that SPLP may have utility as systemic gene delivery systems for gene therapy protocols.  (+info)

Headline: Bitcoin & Blockchain Searches Exceed Trump! Blockchain Stocks Are Next!. Soft Gelatin Capsules Market analysis is provided for global market including development trends by regions, competitive analysis of the Soft Gelatin Capsules market. These are also called as softgel. Soft gelatin capsules are manufactured as single piece capsule shell.. Soft Gelatin Capsules are a type of capsules with a solid outer shell and inner surrounding a liquid or semi-solid (inner fill) active ingredient that can be incorporated into the outer shell, the inner fill, or both.. Browse more detail information about Soft Gelatin Capsules market report at: Market Segment by Manufacturers, this report covers. ...
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All subjects received all tested treatments in a randomised, open label, 3-way cross over study. The treatments were:. Single dose of 240 mg faldaprevir in a form of two soft gelatin capsules was administered orally following an overnight or at least 10 hours (h) fast prior the drug administration (Reference treatment). Single dose of 240 mg faldaprevir in a form of two soft gelatin capsules was administered orally 30 minutes (min) after a standard high-fat, high-caloric meal was served. The meal had to be completely consumed within 25 min or less.. Single dose of 240 mg faldaprevir in a form of two soft gelatin capsules was coadministered orally with 40 mg Omeprazole following an overnight or at least 10 hours (h) fast prior the drug administration following multiple dosing of 40 mg omeprazole once daily for 4 days prior the first dose of faldaprevir.. Drug administrations were separated by a washout period of at least 14 days. ...
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Press Release issued Apr 28, 2017: The motive of this strategic research report entitled Global Hard Capsule Grade Gelatin Market 2017-2022 is to provide company officials, industry investors, and Hard Capsule Grade Gelatin industry members with consequential insights to enable them make reliable strategic decisions regarding the opportunities in the global Hard Capsule Grade Gelatin market.
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0058]The stability of the capsules and pirfenidone/excipient formulations provided herein is demonstrated in the results presented in FIG. 8. The 267 mg pirfenidone capsule formulation of FIG. 6 was stored for 18 months under three different storage conditions: 25° C. and 60% relative humidity, 30° C. and 65% relative humidity, and 40° C. and 75% relative humidity. FIG. 8 shows that the dissolution of the capsule and pirfenidone/excipient formulations at 25° C. and 60% relative humidity, 30° C. and 65% relative humidity did not appreciably change over the duration of the 18 month period. The dissolution of the capsule and pirfenidone/excipient formulations at 40° C. and 75% relative humidity did not appreciably change over the initial 12 month period. The dissolution analysis was performed according to the pharmacopoeial dissolution method specified in USP29 using Apparatus 2 (paddles) with water as a solvent and a specification of Q=70% of label claim in 30 minutes. Also shown in FIG. 8, ...
The one-piece capsule design features an easy-to-swallow, tamper-resistant shell that masks taste and smell in a broad range of unique shapes and colors.
Subjects will be hospitalized to the clinical unit on the evening of Day -1. All subjects will receive 1 x 0.5mg oral dose of dutasteride (Sequence A), in the morning; Subjects will remain in the clinical unit until completion of all assessments at 24 hours post-dose on Day 2 including collection of the 24 hour post-dose PK sample. Subjects will return to the unit for the remaining PK samples at 36, 48 and 72 hours. The subject will receive or 5 x 0.1mg oral dose of dutasteride (Sequence B) in similar fashion as that of Sequence A. The two treatment sequences will be separated by a minimum washout period of 28 days to ensure that dutasteride is effectively eliminated from the subject between dosing occasions ...
For several years Cholecalciferol has been available from several pharmaceutical and nutraceutical companies worldwide. However its industrial scale production for use in vitamin supplements has been largely unchanged. Cholecalciferol is generally produced by the ultraviolet irradiation of 7-dehydrocholesterol extracted from lanolin found in sheeps wool. However this process leaves behind some unwanted isomers are formed during irradiation which can affect physical stability and alter potency.. Entod International however, have developed and designed an innovative technique to produce Vitamin D3 at its state-of-the-art plant in Europe which results in the production of the purest and most physically stable form of cholecalciferol. This novel form contains no isomers and therefore maintains its potency throughout the shelf-life of the product.. ...
Easy to read patient leaflet for Nitroglycerin Controlled-Release Capsules. Includes indications, proper use, special instructions, precautions, and possible side effects.
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Sales, means the sales volume of Gelatin Capsule Revenue, means the sales value of Gelatin Capsule This report studies sales (consumption) of Gelatin Capsule in United States market, focuses on the top players, with sales, price, revenue and market share for each player, covering Capsugel Qualicaps ACG ACPL Suheung Farmacapsulas SA ERAWAT PHARMA LIMITED Dah Feng Capsul
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This research work aims to determine the pharmacokinetic parameters and in vitro-in vivo correlation of the selected ileocolonic-targeted coated mini-tablet filled capsule formulation of naproxen. The pure suspension and coated mini-tablet filled capsule formulation of naproxen were administered to adult albino rabbits through the oral route. The samples were analyzed for naproxen by an HPLC method. For the pure drug suspension, the peak plasma concentration was found as 8.499±0.029 μg/ml at 1.139±0.010 hours and the half-life was found to be 9.459±0.387 hours, whereas for the formulation the peak plasma concentration was found as 6.814±0.037 μg/ml at 8.042±0.069 hours and the half-life was found to be 19.657±0.359 hours. This decreased the peak plasma concentration at a delayed time and increased the half-life of the capsule formulation in comparison with the pure drug suspension which showed that naproxen was only targeted to the ileocolonic region. A significant in vitro-in vivo correlation
A study by light microscopy, using Leishman's stain alone or Leishman's stain followed by nigrosin, showed the presence of capsules on gonococci of two strains subcultured from subcutaneous chambers in guinea pigs. With the Alcian blue method of preparation for electron microscopy, gonococci of both strains recently grown in vivo showed densely stained capsules on some cells, while others in the same preparation showed only irregular masses of dense material on their surfaces with strands connecting adjacent bacteria. Treatment with antiserum, complement and conglutinin revealed irregular masses and strands of extracellular material with fixatives that did not contain Alcian blue.
Swelling behaviour is one of the important properties for microcapsules made by hydrogels, which always affects the diffusion and release of drugs when the microcapsules are applied in drug delivery systems. In this paper, alginate-chitosan microcapsules were prepared by different technologies called external or internal gelation process respectively. With the volume swelling degree (S-w) as an index, the effect of properties of chitosan on the swelling behaviour of both microcapsules was investigated. It was demonstrated that the microcapsules with low molecular weight and high concentration of chitosan gave rise to low S-w. Considering the need of maintaining drug activity and drug loading, neutral pH and short gelation time were favorable. It was also noticed that S-w of internal gelation microcapsules was lower than that of external gelation microcapsules, which was interpreted by the structure analysis of internal or external gelation Ca-alginate beads with the aid of confocal laser ...
Guidelines for medication administration include the recommendation: "Liquid dosage forms should be used when available and if appropriate. Only immediate-release solid dosage forms may be substituted. Grind simple compressed tablets to a fine powder and mix with sterile water. Open hard gelatin capsules and mix powder with sterile water."21 Drug dosage forms include solids (capsules, tablets) and liquids (solutions, suspensions). Most solids are immediate-release products (compressed tablets, hard gelatin capsules) that contain the active drug molecule mixed with inactive ingredients. Immediate-release products are designed to release the drug within minutes of reaching the stomach following oral administration. But more and more drugs have been introduced as modified-release products (enteric-coated, extended-release, sustained-release).. Drugs manufactured for oral administration are designed specifically for the healthy GI tract. Destroying the carefully designed delivery mechanisms by ...
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Empty Capsules Market by Product (Hard gelatin, Non-gelatin capsules), Raw Material (Pig meat, Bovine, HPMC), Therapeutic Application (Antibiotics, Vitamins) & by End User (Pharmaceutical, Health Supplements) - Global Forecast to 2019 - New research available at Over the last decade, the empty capsules market is experiencing growth primarily due to the rising aging population and technological innovations in the empty capsules market. The fast-growing pharmaceutical and nutraceutical industries are catalyzing the growth of the empty capsules market. In this report, the global empty capsules market is segmented by products, source of raw materials, therapeutic applications, and end users. The empty capsules products market is segmented into hard gelatin capsules and nongelatin-based capsules. The empty capsules market segmentation by source of raw materials consists of pig-skin gelatin, bone-derived gelatin, bovine-hide gelatin, hydroxypropyl methyl cellulose (HPMC), ...
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Hard gelatin capsules contain: (a) a fat-soluble nutrient, such as a fat-soluble vitamin (A, D, E or K) or an unsaturated fatty acid glyceride; (b) a nonionic surfactant, such as a polyoxyethylated (optionally hydrogenated) castor oil, and/or a polyethylene glycol; (c) a gelatin softening agent such as glycerol, propylene glycol or, preferably, glyceryl mono-oleate; and optionally (d) water. The problems of embrittlement conventionally encountered with hard gelatin capsules containing fat-soluble nutrients are reduced or avoided.
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The present invention relates to a pharmaceutical formulation for oral administration through a soft gelatin capsule drug delivery device, wherein the said pharmaceutical formulation comprises essentially of Pseudoephedrine HCI as the active ingredient. The active pharmaceutical ingredient is embedded into an oily matrix, also the formulation comprises of viscosity imparting agents, a surfactant; a suspending agent; and a suspension medium. The viscosity-imparting agents are partially hydrogenated vegetable oil and colloidal silicon dioxide, the surfactant is lecithin, the suspending agent is yellow beeswax, and the suspension medium is soybean oil. The formulation comprises of about 60 mg by weight of Pseudoephedrine HCI, about15-25 mg by weight of partially hydrogenated vegetable oil, about 10-20 mg by weight of yellow beeswax, about 2-8 mg by weight of lecithin, about 2-8 mg by weight of silicon dioxide; and about 150-250 mg by weight of soybean oil. Also the invention is addressed at the ...
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Alpha products is a diverse pharmaceutical manufacturing and exporting part of Zenlabs Ethica Ltd. We supply healthcare products to healthcare professionals and institutions all over the world. Alpha products has a wealth of experience in manufacturing and has established a reputation for consistent product quality and reliability of service to our customers across the globe. We deliver quality assured soft gelatin capsules (general+ neutraceutical preparations); also pack and ship to ensure the orders safe arrival by the most effective freight option ...
Nordic Naturals Prenatal DHA is a high concentrate DHA supplement for mood support, proper memory, and neurological function, and proper infant development. Encapsulated in small, easy-to-swallow soft gelatin capsules, Nordic Naturals Prenatal DHA is a healthy way to ensure adequate intake of the essential brain nutrient, DHA. Ingredients: purified deep sea fish oil (from anchovies and sardines), soft gel capsule (gelatin, water, glycerin), d-alpha tocopherol, rosemary extract Each 2 soft gel serving provides: DHA: 450 mg Other Omega-3s: 40 mg EPA: 90 mg Vitamin E (d-alpha tocopherol): 15 IU All Nordic Naturals products are doctor recommended, pharmaceutical grade, molecularly distilled, and third party tested to document the absence of all environmental pollutants (No PCBs, dioxins, pesticides or heavy metals). Our featured products are flavored using our patented processing with natural lemon and strawberry essence! Suggested Use: Two soft gels daily, with food, or as directed by your
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Carlson Labs Very Finest Fish Oil Lemon Flavor 120 Soft Gels Medical Scientists internationally are encouraging people to eat more fish. Fish body oil is the ONLY MAJOR SOURCE of the polyunsaturated Omega-3s EPA and DHA. For those individuals who do not eat an oily fish diet, Carlson offers Omega-3s in easy-to-swallow soft gelatin capsules. Carlson soft gels contain 1000 mg (1 gram) of a special concentrate of fish body oils from deep, cold water fish which are especially rich in the important Omega-3s EPA and DHA. THIS PRODUCT is regularly tested (using AOAC international protocols) for freshness, potency and purity by an independent, FDA-registered laboratory and has been determined to be fresh, fully potent and free of detrimental levels of mercury, cadmium, lead, PCBs and 28 other contaminants. Supplement Facts Serving Size 1 Softgel Servings Per Container 120 Calories 10 Calories from Fat 10 Total Fat 1g 2% Cholesterol 4mg 1% Vitman E Natural (d-alpha tocopherol) 10U
E-GEMS PLUS are soft gelatin capsules providing the full biological potency of vitamin E as d-alpha tocopherol plus the antioxidant value of other tocopherols including d-beta‚ d-delta‚ and d-gamma tocopherols in significant amounts. Independent assays results of E-GEMS PLUS show each tocopherol‚ d-alpha‚ d-beta‚ d-delta‚ and d-gamma‚ listed in significant amounts.. These statements have not been evaluated by the Food and Drug Administration (FDA). These products are not meant to diagnose‚ treat or cure any disease or medical condition. Please consult your doctor before starting any exercise or nutritional supplement program or before using these or any product during pregnancy or if you have a serious medical condition. ...
Youre a health mastermind and creativity is what you do. You dont need pre-packed pills, you prefer the DIY route in life. Our empty capsules are about 3/4" long and 1/4" in diameter. Youll be able to fill approximately 400-800 mg of whatever powder you need to take within them. Easy to fill and easy to swallow, we guarantee the same level of quality youd receive while ingesting our own supplements. ...
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New anionic polyelectrolyte tetra-copolymers with photo-crosslinkable 4-(4-methoxycinnamoyl)phenyl methacrylate monomer in addition to a HEMA-MMA-MAA ter-copolymer system were synthesized. The tetra-copolymers were used to form photo-crosslinkable microcapsules with modified collagen by complex coacervation for rat hepatocytes encapsulation. The hepatocytes were encapsulated within a two-layered membrane comprising of modified collagen as the inner core and an outer photo-crosslinkable copolymer shell. Upon photo-crosslinking of the microcapsules with UV-Vis light irradiation, the mechanical strength and chemical stability of the microcapsules, and the cellular functions of the encapsulated hepatocytes were enhanced. Particularly, the mechanical stability of the microcapsules was dramatically strengthened. The new photo-crosslinkable tetra-copolymer formulation described in this article has opened a way to the development of hepatocyte microencapsulation technology for bioartifical liver assist ...
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Follow practitioners advice. Certain Standard Process supplements may feature a clear gelatin capsule as opposed to a colored gelatin capsule. If youre accustomed to receiving these supplements in colored gelatin capsules, please be advised that there are absolutely no changes to the formulation or capsule weight of each supplement.. If you identify Standard Process supplements by color, it is recommended that Standard Process supplements be kept in their original bottle or that pillboxes be appropriately labeled.. Please note that if you still have Standard Process supplements that feature the colored gelatin capsule, there are no health concerns with them.. These statements have not been evaluated by the Food and Drug Administration (FDA). These products are not meant to diagnose‚ treat or cure any disease or medical condition. Please consult your doctor before starting any exercise or nutritional supplement program or before using these or any product during pregnancy or if you have a ...
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MMJ PhytoTech, a drug development company working on cannabinoid-based therapies, plans to initiate clinical studies of new capsule formulations derived from cannabis for the treatment of MS later this year. Their phase 1, safety-oriented clinical studies have been approved by various ethics committees and public health organizations. The company has been actively investigating a new capsule that offers many advantages over smokeable cannabinoid formulations, as oral administration is much more controllable and user-friendly. Furthermore, the company is confident that their capsules can withstand room temperature storage for extended periods of time. In this way, the need for refrigeration is eliminated resulting in lower shipping and storage costs ...
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The raw materials of empty capsules can generally be divided into gelatin capsules and vegetarian capsules. Gelatin is a white or light yellow, translucent, micro-glossy sheet or powder that is degraded by collagen in connective tissue such as animal skin, bone, and sarcolemma. It is a hydrophilic colloid of macromolecules and is a low-calorie health food with high nutritional value. Another large class of capsules are plant capsules. The outer shell of a plant capsule is generally prepared from a material such as starch, HPMC, Pullulan.
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The Olive Group of companies ventured into the world of soft gelatin formulations by setting up its first manufacturing facility over 3 decades ago. Over the years with the advancement and innovation of soft gelatin related technology, and the ever increasing emphasis on cGMP standards, we have set up two state of the art manufacturing units in India.. We are looking for well qualified .experienced and dynamic! personnel for following positions in our USFDA / EU GMP approved , manufacturing facility at Daman;. Post: Manager QA, Executive QC, Production Manager, Warehouse, Engineer. ...
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Elderly: Pharmacokinetic data from fasting elderly patients with ET (age range 65-75 years) compared tofasting adult patients (age range 22-50 years) indicate that the Cmax and AUC of anagrelide were 36% and 61% higher respectively in elderly patients, but that the Cmax and AUC of the active metabolite, 2-amino-5, 6-dichloro-3, 4-dihydroquinazoline, were 42% and 37% lower respectively in the elderly patients. These differences were likely to be caused by lower presystemic metabolism of anagrelide to 2-amino-5, 6-dichloro-3, 4-dihydroquinazoline in the elderly patients. ...
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Solubilization of drugs by cosolvents. In S. H. The condition was characterized by shallowing of the anterior chamber (AC) together with high intraocular pressure (IOP), and usually resulted in blindness.
Empty Capsules Market by Product (Hard gelatin, Non-gelatin capsules), Raw Material (Pig meat, Bovine, HPMC), Therapeutic Application (Antibiotics, Vitamins) & by End User (Pharmaceutical, Health - Market research report and industry analysis - 8630057
Pills / Capsules are the easiest way to take most herbal formulas. There is a difference in pills and capsules when formulas are made in traditional manners.. Capsules are powdered herbal formulas and capsuled in gelatin. Our herbal capsules are 750mg,not the typical 500mg. Thats 25,000 milligrams more that competitors in 100 capsules!. All of our capsule formulas include 20-50% extracts for optimal performance. This also raises our minimum herbal amount to 1250mg per capsule, over double what your getting elsewhere. There are no extra strength formulas here because all of pills and capsules are already extra strength!. ...
A method for the production of microcapsules embedded with pharmaceuticals, peptides, proteins, enzymes and vaccines, which uses biodegradable solvents, and microcapsules free of toxic residual solvents is described. The microcapsules are obtained by spraying of a solution, suspension or water-in-oil dispersion of active materials and biodegradable polymers.
A fibrous article such as yarn, woven and knitted fabric and non-woven fabric is treated with hydrophobic treating agent by applying microcapsules composed of a core constitutent consisting of a non-aqueous solvent solution of the hydrophobic treating agent and a wall constituent containing the core constituent and made up of a thin synthetic resin shell and having a low tenacity at break of at most 100 g/cm2, and then by breaking the applied microcapsules at a breaking force of at least 100 g/cm2 so as to impregnate the fibrous article with the non-aqueous solvent solution which flows out from the broken microcapsules.
The final oral multiple-unit dosage form can be either a hard gelatin capsule filled with pellets or a tablet composed of carefully compressed pellets. Pellets are prepared using different technologies such as layering of the drug solution, suspension or powder on the inactive cores, extrusion/spheronization, and agglomeration in rotogranulators or rotoprocessors, compression, spray drying, or spray congealing
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Composite microcapsules have been aggressively pursued as designed chemical entities for biomedical and other applications. Common preparations rely on multi-step, time consuming processes. Here, we present a single-step approach to fabricate such microcapsules with shells composed of nanoparticle-polyelectr
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The meta-analysis by Triester and colleagues shows that capsule endoscopy is clearly superior to push enteroscopy and small bowel barium radiography for identifying diagnostic abnormalities in patients with OGIB. This was also true for "clinically important findings," defined as lesions definitely or probably the source of bleeding, as determined by the authors of each included study. This is not surprising, as capsule endoscopy has a farther reach and thus will detect lesions farther in the small intestine than push enteroscopy, and small bowel radiography will not detect superficial lesions of the small intestine, the most common sources of OGIB. Little difference, however, existed between capsule endoscopy and push enteroscopy in detecting tumors, arguably the most important lesion causing OGIB. A diagnostic test is only as good as the management to which it leads. In the opinion of this reviewer, a definitive therapeutic procedure (e.g., surgery) is necessary for OGIB only if a tumor is ...
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Probiotics are live microorganisms which when consumed in sufficient amounts are beneficial for human health. Lactobacillus acidophilus is a type of beneficial bacteria that has been studied extensively, for its beneficial properties. The survival and viability of probiotic bacteria is often low under simulated conditions of gastrointestinal tract which increases the chances of potential pathogens to dominate and cause infection. Among several methods that increase the survival of probiotics, Encapsulation serves the most rational technique. Hence this investigation reports the effect of microencapsulation using sodium alginate and starch on the tolerance or survival of probiotic Lactobacillus acidophilus to selected processing conditions and stimulated gastrointestinal environments. Microencapsulation provided better protection at stimulated conditions of gastric pH (1.0 and 2.0) and at high bile salt concentrations (1.0% and 2.0%). The release of the microencapsulated organisms at pH required ...
Soft-gel capsules with CoQ10 in oil suspension[edit]. A successful approach was to use the emulsion system to facilitate ... could be stabilised very effectively by lecithin and were used in the preparation of soft gelatin capsules. In one of the first ... with oil-based softgel capsules in a later study on dogs,[49] the significantly increased bioavailability of CoQ10 was ... with many of them producing significantly better results over oil-based softgel capsules in spite of the many attempts to ...
Capsule[edit]. Thin reticular fibers of reticular connective tissue form a supporting meshwork called reticulin inside the node ... The lymph node capsule is composed of dense irregular connective tissue with some plain collagenous fibers, and a number of ... When lymph fluid enters a node, it drains into the node just beneath the capsule in a space called the subcapsular sinus. The ... The larger trabeculae springing from the capsule break up into finer bands, and these interlace to form a mesh-work in the ...
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Escape capsule inaccessible[edit]. In an emergency, personnel in the rear compartments were to move forward to the third ... One of the rescue capsules was damaged by the storm.[29] On Thursday at 12:00, Popov reported to the General Staff of the Navy ... The rescue capsule in the third compartment was inaccessible, even if it was still usable.[10] ... compartment along with those in the forward compartments and enter a detachable rescue capsule in the sail (or conning tower), ...
Capsule[edit]. Certain strains of S. haemolyticus are capable of producing a capsular polysaccharide (CP).[9][12] S. ... haemolyticus strain JCSC1435 contains a capsule operon located within the "oriC environ".[9] This operon contains 13 ORFs in a ...
Capsule. A gelatinous capsule is present in some bacteria outside the cell membrane and cell wall. The capsule may be ... Capsules are not marked by normal staining protocols and can be detected by India ink or methyl blue; which allows for higher ... may be further covered by a third layer called a capsule. Though most prokaryotes have both a cell membrane and a cell wall, ...
August 30, 1976). "Medicine: Capsules". Time. 108 (9). p. 58. Brody, Jane E. (September 12, 1976). "A chromosome link to crime ...
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In 2013, BMS charged $50 a capsule. In 2018, NextSource charged $768 a capsule. Some doctors said the price increase made it ... CeeNu (lomustine) Capsules data sheet published by the FDA. *Lomustine at the US National Library of Medicine Medical Subject ... "Gleostine (lomustine) Capsules, for Oral Use. Full Prescribing Information" (PDF). NextSource Biotechnology, LLC. Retrieved 15 ...
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Fish oil capsules. Marine and freshwater fish oil vary in content of arachidonic acid, EPA and DHA.[115] They also differ in ...
Personnel Transfer Capsule) or SDC (Submersible Decompression Chamber).[90] The diving bell is the elevator or lift that ... which is commonly referred to in commercial diving as the diving bell and in military diving as the personnel transfer capsule, ...
"Isotretinoin 20mg capsules - - (eMC)". Retrieved 2017-12-27.. ... "Isotretinoin 20mg capsules - - (eMC)". Retrieved 2018-01-10.. ... "Roaccutane 20mg Soft Capsules - Summary of Product Characteristics". UK Electronic Medicines Compendium. 1 July 2015.. ... "Isotretinoin (marketed as Accutane) Capsule Information". U.S. Food and Drug Administration (FDA). 2018-11-03.. ...
"CHEMMART PIROXICAM CAPSULES" (PDF). TGA eBusiness Services. Apotex Pty Ltd. 18 December 2013. Archived from the original on 15 ... "PRODUCT INFORMATION PONSTAN CAPSULES (mefenamic acid)" (PDF). TGA eBusiness Services. Pfizer Australia Pty Ltd. 12 October 2012 ...
The WHO Model List of Essential Medicines (EML), published by the World Health Organization (WHO), contains the medications considered to be most effective and safe to meet the most important needs in a health system.[1] The list is frequently used by countries to help develop their own local lists of essential medicine.[1] As of 2016[update], more than 155 countries have created national lists of essential medicines based on the World Health Organization's model list.[2] This includes countries in both the developed and developing world.[1][3] The list is divided into core items and complementary items.[4] The core items are deemed to be the most cost-effective options for key health problems and are usable with little additional health care resources.[4] The complementary items either require additional infrastructure such as specially trained health care providers or diagnostic equipment or have a lower cost-benefit ratio.[4] About 25% of items are in the complementary list.[5] Some ...
The Old English name of the animal was efte, efeta (of unknown origin), resulting in Middle English eft; this word was transformed irregularly into euft, evete, or ewt(e). The initial 'n' was added from the indefinite article 'an' by provection (juncture loss) ("an eft" -, "a n'eft" -, ...) by the early 15th century.[2] The form 'newt' appears to have arisen as a dialectal variant of eft in Staffordshire, but entered Standard English by the Early Modern period (used by Shakespeare in Macbeth iv.1).[3] The regular form eft, now only used for newly metamorphosed specimens, survived alongside newt, especially in composition, the larva being called "water-eft" and the mature form "land-eft" well into the 18th century, but the simplex "eft" as equivalent to "water-eft" has been in use since at least the 17th century.[4] Dialectal English and Scots also has the word ask (also awsk, esk in Scots[5]) used for both newts and wall lizards, from Old English āþexe, from Proto-Germanic *agiþahsijǭ, ...
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The calyx of Hibiscus trionum has opened apically to reveal the capsule (ovary) inside. The capsule has split vertically in the ... Spathoglottis plicata capsules, like in most orchids, split longitudinally along three to six slits while remaining closed at ... Iridaceae capsules have loculicidal dehiscence; the fruit splits through the ovary wall of each carpel, allowing the seeds to ... The septa between the locules of Ledum palustre capsules split as the fruit opens, and the seeds are released. ...
The joint capsule is a soft tissue envelope that encircles the glenohumeral joint and attaches to the scapula, humerus, and ... The capsule is a soft tissue envelope that encircles the glenohumeral joint and attaches to the scapula, humerus, and head of ... This capsule is strengthened by the coracohumeral ligament which attaches the coracoid process of the scapula to the greater ... This tendon, along with the articular capsule, the coracohumeral ligament, and the glenohumeral ligament complex, blend into a ...
"Omnicef capsules Patient Information" (PDF). Abbott Laboratories. February 2004. Archived from the original (PDF) on 2006-11-18 ... It is available as capsules and a suspension. Dosage, schedule, and duration of therapy varies according to the type of ...
... Limited (帝人株式会社, Teijin Kabushiki-gaisha) is a Japanese chemical, pharmaceutical and information technology company. Its main fields of operation are high-performance fibers such as aramid, carbon fibers & composites, healthcare, films, resin & plastic processing, polyester fibers, products converting and IT products. The company is listed on the first section of the Tokyo Stock Exchange and is a constituent of the Nikkei 225 stock index.[3] As of March 2014, the Teijin Group comprises 151 companies, 56 in Japan and 95 overseas.[1] Teijin is a member of the Mitsubishi UFJ Financial Group (MUFJ) keiretsu. ...
The capsule endoscope includes a light-emitting unit for emitting illumination light for illuminating a view field of the solid ... A capsule endoscope has a solid image sensor introduced into a subject for picking up an image in the subject. ... Capsule endoscope and a capsule endoscope system. US20050124858 *. 31 Aug 2004. 9 Jun 2005. Hirohiko Matsuzawa. Capsule type ... Capsule endoscope. US20040225189 *. 23 Apr 2004. 11 Nov 2004. Olympus Corporation. Capsule endoscope and a capsule endoscope ...
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A conventional capsule endoscope examines the small intestine using a pill-sized video capsule which has its own lens and light ... The magnetic maneuverable capsule (MMC) is a modification of a standard colon capsule with magnetic disks inserted inside one ... Capsule endoscopy might offer a more "patient-friendly" alternative. However, conventional capsule endoscopies have shown that ... A wireless colon capsule for visualizing the colon for screening purposes has been developed, but is not currently FDA approved ...
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Video capsule endoscopy performed in the ED has the potential to safely allow many patients with GI bleeding to be discharged ... Sidhu R, Sanders DS, Kapur K, et al. Capsule endoscopy: is there a role for nurses as physician extenders? Gastroenterol Nurs. ... Video capsule endoscopy was well tolerated by nearly all patients in the study (96%) and showed sensitivity and specificity ... We compared video capsule endoscopy interpretations of emergency physicians who received a brief training to detect fresh blood ...
ARGUELLES-ARIAS, Federico et al. Preparations for colon capsule endoscopy: prospective and randomized comparative study between ... Introduction: PillCam© colon capsule endoscopy (CCE) enables the study of colonic diseases in a safe and non-invasive way, ... capsule endoscopy. Methods: Fifty eight patients included in this prospective study and randomized to: Group A, PEG plus ... two preparations for colon capsule endoscopy: PEG 2 liters + ascorbic acid versus PEG 4 liters. Rev. esp. enferm. dig. [online ...
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Capsule endoscopy with the PillCam ® SB video capsule will provide your doctor with pictures of your small intestine. Feel free ... Capsule endoscopy with the PillCam ® SB video capsule will provide your doctor with pictures of your small intestine. Feel free ... Your doctor may determine that a capsule endoscopy of the small bowel is necessary for further evaluation of your condition. ... Your doctor may determine that a capsule endoscopy of the small bowel is necessary for further evaluation of your condition. ...
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The major salivary glands are encapsulated by a connective capsule, a feature that is absent in minor salivary glands [38]. The ...
OMOM capsule endoscopy in diagnosis of small bowel disease. J Zhejiang Univ Sci B. 2008 Nov. 9(11):857-62. [Medline]. [Full ...
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  • The objective of the study was to assess the safety and efficacy of the manipulation of a modified capsule endoscope with magnetic materials in the human stomach by using a handheld external magnet. (
  • OAK BROOK, Ill. Jan. 18, 2011 A study from researchers in Germany showed that magnetic maneuvering of a modified capsule endoscope in the stomach of healthy volunteers under clinical conditions is safe, well-tolerated, and technically feasible. (
  • A conventional capsule endoscope examines the small intestine using a pill-sized video capsule which has its own lens and light source. (
  • To address the problems with a conventional capsule endoscope in visualizing the stomach, a new tool for maneuvering the capsule using an external handheld magnet was developed, allowing targeted investigation of all regions of the stomach," said study lead author Jutta Keller, MD, Department of Internal Medicine, University of Hamburg, Hamburg, Germany. (
  • The aim of our study was to evaluate the safety and feasibility of the magnetic maneuvering of a capsule endoscope in a human stomach. (
  • A wireless colon capsule for visualizing the colon for screening purposes has been developed, but is not currently FDA approved for use in the U.S. (
  • The magnetic maneuverable capsule (MMC) is a modification of a standard colon capsule with magnetic disks inserted inside one of the domes of the capsule. (
  • However, conventional capsule endoscopies have shown that visualization of the stomach is highly variable. (
  • 11-20-2017] The Food and Drug Administration (FDA) is advising consumers not to purchase or use Control Capsules, a product promoted for sexual enhancement. (
  • In February 2017, a SpaceX Falcon 9 rocket lifted through low clouds, pushing a Dragon capsule toward orbit. (
  • In fact, "There were other time capsules 5,000 years ago as vaults of artifacts hidden inside the walls of Mesopotamian cities, along with Egyptian and other ancient tombs, which are effectively time capsules as well. (
  • Signers received tin pins, about 1.2 inches (30 mm) across (roughly the size of an American fifty-cent piece), stating, My name is in the Westinghouse Time Capsule for the next 5,000 years. (
  • The purpose of this book is to preserve knowledge of the existence of the time capsule for 5,000 years, and to provide assistance to the people of the year 6939 in locating and recovering it. (
  • A Soyuz capsule carrying two Russians cosmonauts and a U.S. astronaut back on Earth after departing the International Space Station. (
  • An international three-man crew onboard a Russian-made Soyuz capsule touched down successfully on the cloudless central Kazakhstan steppe Monday morning after 123 days at the International Space Station. (
  • FDA laboratory analysis confirmed that Control Capsules contain sildenafil, the active ingredient in the FDA-approved prescription drug Viagra, used to treat erectile dysfunction. (
  • With those stakes, the last thing scientists, engineers, and citizens want is for a private company's capsule to muck up measurements. (
  • Writer patient studies from doxycycline are expensive bacterial but it can cause time, synthesis and a expired" effectsside in capsules some costs. (
  • Back up a lifetime's worth of memories with AirPort Time Capsule, a wireless hard drive that works seamlessly with Time Machine in OS X. It's also a full-featured Wi-Fi base station with the latest 802.11ac technology and simultaneous dual-band support. (
  • AirPort Time Capsule includes a 2TB or 3TB hard drive that works with Time Machine in OS X to create the perfect no-hassle backup solution. (
  • With 802.11ac technology and a powerful beamforming antenna array, AirPort Time Capsule gives you up to 3x faster Wi-Fi and a stronger, clearer signal. (
  • With the antennas at the top of the elevated design, AirPort Time Capsule now has a higher platform for dispersing the signal. (
  • Connect your DSL or cable modem to AirPort Time Capsule and use the built-in setup assistant to create your new wireless network in just a few taps from your iPhone, iPad, or iPod touch. (
  • AirPort Time Capsule can turn any external USB hard drive into a secure drive you can share across your Wi-Fi network. (
  • Any Wi-Fi device you have will work with AirPort Time Capsule. (
  • And since AirPort Time Capsule features a built-in firewall that protects your network from malicious Internet attacks, you can enjoy the web with peace of mind. (
  • MACWORLD SAN FRANCISCO-January 15, 2008-Apple® today introduced Time Capsule, a backup appliance that automatically and wirelessly backs up everything on one or more Macs running Leopard™, the latest release of Apple's Mac OS® X operating system including the amazing Time Machine™ automatic backup software. (
  • Time Capsule combines an 802.11n base station with a server grade hard disk in one small package. (
  • Simply plug it in, then easily set up automatic wireless backup for every Mac® in your house to a single Time Capsule with just a few clicks. (
  • Time Capsule offers the benefits of a full-featured 802.11n Wi-Fi base station, and comes in two models: a 500 gigabyte model for just $299 and a 1 terabyte model for just $499. (
  • Bring Time Capsule home, plug it in, click a few buttons on your Macs and voila-all the Macs in your house are being backed up automatically, every hour of every day," said Steve Jobs, Apple's CEO. (
  • With Time Capsule and Time Machine, all your irreplaceable photos, movies and documents are automatically protected and incredibly easy to retrieve if they are ever lost. (
  • Built to work seamlessly with Time Machine, Time Capsule lets users wirelessly back up all of the data on their Macs, find lost files and even restore all of their software. (
  • If it's ever necessary, Leopard can also easily restore an entire system from the Time Machine backup on Time Capsule. (
  • In addition to being the best way to back up a Mac, Time Capsule is also a full-featured Wi-Fi base station with the latest 802.11n technology. (
  • Time Capsule features a sleek design with a built-in power supply and connections to print wirelessly to a USB printer. (
  • With Time Capsule, it's very easy for users to create a secure, wireless network for up to 50 users and set security restrictions such as Internet access limits for children's computers. (
  • At $299 for a 500GB model and $499 for a 1TB model and a fully integrated 802.11n AirPort Extreme® Base Station, Time Capsule can serve as a backup solution for multiple computers as well as the backbone for a high-speed, 802.11n wireless network, making it effortless and affordable for everyone at home, school or work to protect their digital files. (
  • Time Capsule will be available in February through the Apple Store® ( ), at Apple's retail stores and Apple Authorized Resellers for a suggested retail price of $299 (US) for a 500GB hard drive and $499 (US) for a 1TB hard drive. (
  • Time Capsule is based on an IEEE 802.11n draft specification. (
  • Could you please tell me what the 'time capsule' means in the following context? (
  • A 'time capsule' is usually a box that is sealed and often buried containing items typical of the time, like newspapers, magazines or anything else that is suggested as representing life at that time. (
  • I understand the original meaning of 'time capsule' (I actually made it when I was younger), but I suppose this is used as a different meaning in that context. (
  • what goes into a time-capsule are usually everyday items which nevertheless are iconic of the age. (
  • To say his 'stupid remark' is going into a time-capsule suggests that it is the epitome of all stupid remarks ever to be made. (
  • In my language we would not use 'time capsule' to express such a meaning. (
  • A milestone birthday, a college party house, and an eighteen-year-old time capsule. (
  • Everybody had turned forty or was about to, so, even though the time capsule had been in the ground for only eighteen years, not a significant number, we decided to dig it up. (
  • Then, at once, before you knew it, the time for the Time-Capsule Party had arrived-a last hurrah. (
  • Most of the time, the capsule leaves the body within 24 hours. (
  • A time capsule set Sept. 23, 1925 in the cornerstone of the former Philadelphia Fire Department headquarters at 1328 Race Street is opened. (
  • Back in May, I kicked off a Trump Time Capsule series, designed to note what we knew, when we knew it, about the man who was trying to become president. (
  • The thought occurred to me: This should be in the Trump Time Capsule. (
  • In the meantime, please check out, follow, and contribute to a very interesting Time Capsule project by @motocollard , which you can read about on Medium . (
  • Back during the 2016 campaign, I put out 152 installments of the Trump Time Capsule series, chronicling what was known about this man at just the time the Republican party was deciding to accept (and then embrace) him as its nominee, and as the states of Michigan, Wisconsin, and Pennsylvania were delivering him an Electoral College win. (
  • At last week's village council meeting, she presented two time capsules to Walbridge officials, plus a centennial-year scrapbook to be kept on reserve at the Walbridge Branch of the Wood County Library System that librarian Matt Mehling accepted. (
  • The time capsules, which actually are two safes, will be sealed this week. (
  • Her task as head of objects conservation at Boston's Museum of Fine Arts was to retrieve items which were first place in a time capsule at the State House in 1795. (
  • Adams and Revere were joined in creating the original time capsule by a lesser known revolutionary figure, Colonel William Scollay, who served in the local Boston Militia. (
  • Time capsules have been used for centuries in one form or another - to hide the tombs of Egyptian Kings and to keep histories past living on. (
  • Thornwell Jacobs (1877-1956), referred to as "the father of the modern time capsule," was inspired to construct the crypt after the openings of the Egyptian Pyramids and tombs in 1920. (
  • Egyption tombs have been referred to as "Time Capsules" for centuries. (
  • Egyptian tombs were not created as time capsules. (
  • Maybe the screenwriters for "Knowing" mistakenly used the 8113 year as the time when that final cataclysm would occur, then just went ahead and decided to do the time capsule opening in 2009 to save money. (
  • Delivering the intense flavor and rich aroma of Nespresso's premeasured coffee capsules, Citiz's sleek, compact, award-winning design frees up space on your countertop while brewing the perfect cup of espresso every time. (
  • The Westinghouse Time Capsules are two time capsules prepared by the Westinghouse Electric & Manufacturing Company: "Time Capsule I" was created for the 1939 New York World's Fair and "Time Capsule II" was created for the 1964 New York World's Fair. (
  • The capsules are to be opened at the same time in the year 6939, five thousand years after the first capsule was sealed. (
  • The time capsules are bullet-shaped, measure 90 inches (2.3 m) in length, and have an exterior casing of about 8.75 inches (22.2 cm) in diameter. (
  • Time Capsule I weighs about 800 pounds (360 kg), while Time Capsule II weighs about 400 pounds (180 kg). (
  • Time Capsule I was made of a non-ferrous alloy called Cupaloy, created especially for this project. (
  • Time Capsule II was made of a stainless steel metal called Kromarc, supplied by U.S. Steel. (
  • The contents of the time capsules were sealed inside an insulated, airtight, glass envelope with an interior diameter of 6.5 inches (17 cm) and a length of about 81 inches (210 cm). (
  • The term "time capsule" was coined by George Edward Pendray for the 1939 World's Fair Westinghouse exhibit in New York. (
  • Among the 35 small, everyday items placed inside Time Capsule I were a fountain pen and an alphabet block set. (
  • Time Capsule I also contained 75 types of fabrics, metals, and plastics. (
  • The book's pages were photographed onto acetate microfilm and placed into the time capsule. (
  • An exact duplicate of the capsule's articles resides at the Heinz History Center beside a replica capsule of Time Capsule I. The contents of Time Capsule I were recorded in a Book of Record of the Time Capsule of Cupaloy. (
  • In order to avoid confusion about the 1965 time capsule, a supplement announcing Time Capsule II was sent to the original 3,000 depositories of the 1938 edition. (
  • Do that chew, 250mg capsule amoxil divide, or break allergic une sites and price lines. (
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  • Migraine formula caplets are coated caplets (capsule-shaped tablets) and contain acetaminophen 250mg, aspirin (NSAID) 250mg and caffeine 65mg. (
  • Chile portal Mining portal Disasters portal Quecreek Mine Rescue involved a similar rescue capsule in Pennsylvania, July 2002 to rescue a trapped mining crew. (
  • This invention relates to an apparatus for manufacturing seamless material-filled capsules, and miniature capsules having the values of particle diameter 0.5-4 mm, weight 1-30 mg, film percentage 5-30% and film thickness 0.05-0.2 mm. (
  • The Fénix 1 had a larger diameter than the other two capsules and was used in tests in the shaft created by the T-130 drill, where it descended to a depth of 610 metres (2,000 ft). (
  • This capsule uses the determinants of matrices to study Fibonacci numbers. (
  • This new technology complements Capsugel Dosage Form Solutions' array of modified and targeted release technologies utilized to optimize drug delivery, including a range of multi-particulate formulation options, osmotic tablets, bi- and tri-layered matrices, dual capsule technology and colonic delivery approaches. (
  • This breakthrough drug-delivery technology integrates industry-approved enteric polymers in the capsule design, enabling Capsugel to offer the first fully enteric dosage form without the need to apply functional coatings. (
  • Capsugel's enteric capsule technology lead-user programs include feasibility studies with selected customers that target oral vaccine and peptide delivery, as well as early-stage development programs for small chemical entities that could benefit from an intrinsically enteric dosage form. (
  • Medication related microbial againscissors were next, and doxycycline capsules used treat not led to next-day of the check moisturizer. (
  • FRIDAY, Aug. 16, 2019 (HealthDay News) -- Inrebic (fedratinib) capsules have been approved to treat adults with intermediate-2 or high-risk primary or secondary myelofibrosis, making it the second drug approved to treat patients with this disease, the U.S. Food and Drug Administration announced today. (
  • After swallowing it, the capsule travels the length of your digestive system and transmits images to a wearable recorder. (
  • Contact your smell if you experience these content studies and doxycycline capsules used treat they are i' or marked. (
  • Filter-content material for the individual capsules is extruded as a stream through the central opening and a settable coating liquid material is extruded as a thin film sleeve circumferentially of the filler-content material stream. (
  • The content of the capsules, protected by a membrane, is released once it comes in contact with moisture during a wash. (
  • It combines our drug formulation, polymer chemistry and capsule-design expertise to achieve this targeted drug-delivery characteristic," said Keith Hutchison, PhD, Senior Vice President, Research & Development, Capsugel. (
  • Mind that good miners and capsule practitioners may moderately interact with the late periods with clomid trunk. (
  • The Fénix capsules were three metallic containers that were used for the rescue of 33 trapped miners after the 2010 Copiapó mining accident, and are an enhanced version of the Dahlbusch Bomb. (
  • The Fénix capsules have a harness to hold the occupant, an oxygen supply, and a microphone with speakers, which were used to connect the miners with the rescuers at the surface during the rescue. (
  • The senior valuer for auctioneers Dominic Winter in Gloucestershire, England said "The capsule is a 21st-century icon and symbolizes many things including the triumph of hope and the human spirit over adversity, teamwork and technology over nature and the myriad of uplifting stories of the 33 miners and their families. (
  • It follows that preparation infections should be done for all products with various ", doxycycline capsules used treat both to confirm the site and coupon to better predict the beneficial and online niet. (
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  • The capsule, which took five years to develop, weighs 2,900 pounds (1,315 kilograms) fully loaded and measures 11 feet (3.4 m) high by 8 feet (2.4 m) wide at its base. (
  • SpaceX's Dragon capsule is seen departing the International Space Station on Sunday, May 18, 2014. (
  • NASA astronaut and station commander Steve Swanson controlled a 58-foot robotic arm that pulled the Dragon from its Harmony node port at 8 a.m., then released the capsule into space 266 miles over the ocean south of Australia. (
  • The concept of the capsule as a building element of architecture, as well as a spatial element, can therefore be regarded as having a generative potential for an architecture of personal space for the individual, forcing us to reflect on our existing living and dwelling conditions. (
  • Baumgartner, a 42-year-old Austrian, aims to break four separate records when he steps out of the capsule into empty air on the so-called 'space jump' later this year. (
  • Today, the company plans to launch another Dragon capsule full of cargo, and perhaps outgassing contaminants, to the Space Station. (
  • General mess in the space capsule department. (
  • Much of the science from NASA's Genesis space capsule, which crashed in Utah on 8 September, will probably be salvaged, mission scientists say. (
  • The capsule spent 27 months in space, collecting charged particles blown on the solar wind from the Sun's outermost layer. (
  • NASA launched its unmanned space capsule Orion at Cape Canaveral Air Force Station on Friday morning. (
  • The Fénix capsules were designed by the Chilean Navy, in collaboration with the United States space agency NASA. (
  • Five categories of objects were placed inside Capsule I: Small articles of common use Textiles and materials Essay in microfilm RKO newsreel Miscellaneous items Five main categories of objects were placed in Capsule II: Articles in common use Atomic energy Scientific developments Space Other The "other" category included images of a guest book signed by visitors to the Westinghouse pavilion at the 1964 fair. (
  • Pregnacare Max dual pack includes essential vitamins and minerals such as 100mcg vitamin D and 500mg Calcium, as well as a 300mg Omega-3 DHA capsule which contributes to normal foetal brain and eye development. (
  • MELBOURNE, Fla. - One month after it launched from Cape Canaveral, Fla., SpaceX's Dragon cargo capsule is on its way back to Earth. (
  • Previously, the formation of capsules has been achieved by coacervation, in which a shell is caused to form on dispersed core particles. (
  • It has now been found that it is possible to prepare core-shell capsules by a simple method that avoids the complexities of known methods. (
  • The interior of the glass envelope of Capsule I was filled with nitrogen, whereas Capsule II was filled with the inert gas, argon. (
  • Initial treatment of acne: one capsule (100 mg doxycycline) daily. (
  • Initial inspections of the ruptured capsule at an airbase near the crash site suggest many, if not all, of the capsule's hexagonal particle collectors are broken. (
  • But the process for regulating the capsules is murky, and they could contribute to spreading infection from mother back to baby. (
  • The capsule will drift back down to Earth via parachute, where teams will recover it. (
  • the early childhood health centres of many local councils, like Darebin , began hiring the capsules to fresh parents. (
  • Health professionals are warning new moms that consuming placenta capsules can carry health risks, and there's a lack of oversight in how they're made. (
  • The health care provider may ask you to lie down or sit up while swallowing the capsule. (
  • Usual adult dosage: 2 capsules, 2 times a day or as needed. (
  • Already in the beginning of the capsule design I made 3 openings cuts in the hull without knowing what should be placed here in details. (
  • Moreover, the seamless material-filled capsules thus obtained by the apparatus of the present invention can occur as miniature capsules, namely, in the form of much smaller capsules than capsules obtained by a conventional apparatus. (
  • Piroxicam capsules are a non-steroidal anti-inflammatory drug (NSAID) that exhibits anti-inflammatory, analgesic, and antipyretic activities in animal models. (