Capreomycin: Cyclic peptide antibiotic similar to VIOMYCIN. It is produced by Streptomyces capreolus.Viomycin: A strongly basic peptide, antibiotic complex from several strains of Streptomyces. It is allergenic and toxic to kidneys and the labyrinth. Viomycin is used in tuberculosis as several different salts and in combination with other agents.Enviomycin: Cyclic basic peptide related to VIOMYCIN. It is isolated from an induced mutant of Streptomyces griseoverticillatus var. tuberacticus and acts as an antitubercular agent with less ototoxicity than tuberactinomycin.Kanamycin: Antibiotic complex produced by Streptomyces kanamyceticus from Japanese soil. Comprises 3 components: kanamycin A, the major component, and kanamycins B and C, the minor components.Antitubercular Agents: Drugs used in the treatment of tuberculosis. They are divided into two main classes: "first-line" agents, those with the greatest efficacy and acceptable degrees of toxicity used successfully in the great majority of cases; and "second-line" drugs used in drug-resistant cases or those in which some other patient-related condition has compromised the effectiveness of primary therapy.Amikacin: A broad-spectrum antibiotic derived from KANAMYCIN. It is reno- and oto-toxic like the other aminoglycoside antibiotics.Antibiotics, Antitubercular: Substances obtained from various species of microorganisms that are, alone or in combination with other agents, of use in treating various forms of tuberculosis; most of these agents are merely bacteriostatic, induce resistance in the organisms, and may be toxic.Mycobacteriaceae: A family of gram-positive bacteria found in soil and dairy products and as parasites on animals and man. Several are important pathogens.Extensively Drug-Resistant Tuberculosis: Tuberculosis resistant to ISONIAZID and RIFAMPIN and at least three of the six main classes of second-line drugs (AMINOGLYCOSIDES; polypeptide agents; FLUOROQUINOLONES; THIOAMIDES; CYCLOSERINE; and PARA-AMINOSALICYLIC ACID) as defined by the CDC.Mycobacterium tuberculosis: A species of gram-positive, aerobic bacteria that produces TUBERCULOSIS in humans, other primates, CATTLE; DOGS; and some other animals which have contact with humans. Growth tends to be in serpentine, cordlike masses in which the bacilli show a parallel orientation.Tuberculosis, Multidrug-Resistant: Tuberculosis resistant to chemotherapy with two or more ANTITUBERCULAR AGENTS, including at least ISONIAZID and RIFAMPICIN. The problem of resistance is particularly troublesome in tuberculous OPPORTUNISTIC INFECTIONS associated with HIV INFECTIONS. It requires the use of second line drugs which are more toxic than the first line regimens. TB with isolates that have developed further resistance to at least three of the six classes of second line drugs is defined as EXTENSIVELY DRUG-RESISTANT TUBERCULOSIS.Ribosome Subunits: The two dissimilar sized ribonucleoprotein complexes that comprise a RIBOSOME - the large ribosomal subunit and the small ribosomal subunit. The eukaryotic 80S ribosome is composed of a 60S large subunit and a 40S small subunit. The bacterial 70S ribosome is composed of a 50S large subunit and a 30S small subunit.Powders: Substances made up of an aggregation of small particles, as that obtained by grinding or trituration of a solid drug. In pharmacy it is a form in which substances are administered. (From Dorland, 28th ed)Georgia (Republic)Dry Powder Inhalers: A device that delivers medication to the lungs in the form of a dry powder.Microbial Sensitivity Tests: Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses).Universal Precautions: Prudent standard preventive measures to be taken by professional and other health personnel in contact with persons afflicted with a communicable disease, to avoid contracting the disease by contagion or infection. Precautions are especially applicable in the diagnosis and care of AIDS patients.Library Services: Services offered to the library user. They include reference and circulation.Libraries, MedicalPamphlets: Printed publications usually having a format with no binding and no cover and having fewer than some set number of pages. They are often devoted to a single subject.Tuberculosis: Any of the infectious diseases of man and other animals caused by species of MYCOBACTERIUM.Tuberculosis, Pulmonary: MYCOBACTERIUM infections of the lung.World Health: The concept pertaining to the health status of inhabitants of the world.Tuberculosis, Lymph Node: Infection of the lymph nodes by tuberculosis. Tuberculous infection of the cervical lymph nodes is scrofula.Tuberculosis, Osteoarticular: Tuberculosis of the bones or joints.Biological Science Disciplines: All of the divisions of the natural sciences dealing with the various aspects of the phenomena of life and vital processes. The concept includes anatomy and physiology, biochemistry and biophysics, and the biology of animals, plants, and microorganisms. It should be differentiated from BIOLOGY, one of its subdivisions, concerned specifically with the origin and life processes of living organisms.Software: Sequential operating programs and data which instruct the functioning of a digital computer.User-Computer Interface: The portion of an interactive computer program that issues messages to and receives commands from a user.Algorithms: A procedure consisting of a sequence of algebraic formulas and/or logical steps to calculate or determine a given task.Computational Biology: A field of biology concerned with the development of techniques for the collection and manipulation of biological data, and the use of such data to make biological discoveries or predictions. This field encompasses all computational methods and theories for solving biological problems including manipulation of models and datasets.ArchivesMedical Illustration: The field which deals with illustrative clarification of biomedical concepts, as in the use of diagrams and drawings. The illustration may be produced by hand, photography, computer, or other electronic or mechanical methods.Cholera Vaccines: Vaccines or candidate vaccines used to prevent infection with VIBRIO CHOLERAE. The original cholera vaccine consisted of killed bacteria, but other kinds of vaccines now exist.Cholera: An acute diarrheal disease endemic in India and Southeast Asia whose causative agent is VIBRIO CHOLERAE. This condition can lead to severe dehydration in a matter of hours unless quickly treated.Vaccines: Suspensions of killed or attenuated microorganisms (bacteria, viruses, fungi, protozoa), antigenic proteins, synthetic constructs, or other bio-molecular derivatives, administered for the prevention, amelioration, or treatment of infectious and other diseases.Physician-Patient Relations: The interactions between physician and patient.Vaccines, Inactivated: Vaccines in which the infectious microbial nucleic acid components have been destroyed by chemical or physical treatment (e.g., formalin, beta-propiolactone, gamma radiation) without affecting the antigenicity or immunogenicity of the viral coat or bacterial outer membrane proteins.Cholera Toxin: An ENTEROTOXIN from VIBRIO CHOLERAE. It consists of two major protomers, the heavy (H) or A subunit and the B protomer which consists of 5 light (L) or B subunits. The catalytic A subunit is proteolytically cleaved into fragments A1 and A2. The A1 fragment is a MONO(ADP-RIBOSE) TRANSFERASE. The B protomer binds cholera toxin to intestinal epithelial cells, and facilitates the uptake of the A1 fragment. The A1 catalyzed transfer of ADP-RIBOSE to the alpha subunits of heterotrimeric G PROTEINS activates the production of CYCLIC AMP. Increased levels of cyclic AMP are thought to modulate release of fluid and electrolytes from intestinal crypt cells.Phytotherapy: Use of plants or herbs to treat diseases or to alleviate pain.Clofazimine: A fat-soluble riminophenazine dye used for the treatment of leprosy. It has been used investigationally in combination with other antimycobacterial drugs to treat Mycobacterium avium infections in AIDS patients. Clofazimine also has a marked anti-inflammatory effect and is given to control the leprosy reaction, erythema nodosum leprosum. (From AMA Drug Evaluations Annual, 1993, p1619)Ethambutol: An antitubercular agent that inhibits the transfer of mycolic acids into the cell wall of the tubercle bacillus. It may also inhibit the synthesis of spermidine in mycobacteria. The action is usually bactericidal, and the drug can penetrate human cell membranes to exert its lethal effect. (From Smith and Reynard, Textbook of Pharmacology, 1992, p863)Clarithromycin: A semisynthetic macrolide antibiotic derived from ERYTHROMYCIN that is active against a variety of microorganisms. It can inhibit PROTEIN SYNTHESIS in BACTERIA by reversibly binding to the 50S ribosomal subunits. This inhibits the translocation of aminoacyl transfer-RNA and prevents peptide chain elongation.Mycobacterium avium Complex: A complex that includes several strains of M. avium. M. intracellulare is not easily distinguished from M. avium and therefore is included in the complex. These organisms are most frequently found in pulmonary secretions from persons with a tuberculous-like mycobacteriosis. Strains of this complex have also been associated with childhood lymphadenitis and AIDS; M. avium alone causes tuberculosis in a variety of birds and other animals, including pigs.Mycobacterium avium-intracellulare Infection: A nontuberculous infection when occurring in humans. It is characterized by pulmonary disease, lymphadenitis in children, and systemic disease in AIDS patients. Mycobacterium avium-intracellulare infection of birds and swine results in tuberculosis.Mycobacterium avium: A bacterium causing tuberculosis in domestic fowl and other birds. In pigs, it may cause localized and sometimes disseminated disease. The organism occurs occasionally in sheep and cattle. It should be distinguished from the M. avium complex, which infects primarily humans.Drug Therapy, Combination: Therapy with two or more separate preparations given for a combined effect.Amphotericin B: Macrolide antifungal antibiotic produced by Streptomyces nodosus obtained from soil of the Orinoco river region of Venezuela.Atovaquone: A hydroxynaphthoquinone that has antimicrobial activity and is being used in antimalarial protocols.Bithionol: Halogenated anti-infective agent that is used against trematode and cestode infestations.Proguanil: A biguanide compound which metabolizes in the body to form cycloguanil, an anti-malaria agent.Colloids: Two-phase systems in which one is uniformly dispersed in another as particles small enough so they cannot be filtered or will not settle out. The dispersing or continuous phase or medium envelops the particles of the discontinuous phase. All three states of matter can form colloids among each other.Antifungal Agents: Substances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues.

In vitro microbiological characterization of novel cyclic homopentapeptides, CP-101,680 and CP-163,234, for animal health use. (1/49)

Two cyclic homopentapeptides, CP-101,680 and CP-163,234 [6a-(3',4'-dichlorophenylamino) analogs of viomycin and capreomycin, respectively], were identified as novel antibacterial agents for the treatment of animal disease, especially for livestock respiratory disease. The in vitro microbiological characterization of both CP-101,680 and CP-163,234 was carried out using their parent compounds, viomycin and capreomycin, as controls. This characterization included antibacterial spectrum, influence of media, inoculum size, pH, EDTA, polymixin B nonapeptide (PMBN), serum, cell-free protein synthesis inhibition, and time-kill kinetics. Our results indicated that the capreomycin analog, CP-163,234, showed slightly improved in vitro potency over the viomycin analog, CP-101,680. Both analogs showed very potent cell-free protein synthesis inhibition activity and were bactericidal against Pasteurella haemolytica, P. multocida and Actinobacillus pleuropneumoniae at the level of 4 times and 8 times MICs. CP-163,234 was bactericidal at the level of 4x and 8x MIC against E. coli, but re-growth was observed after 24 hours incubation at both concentrations of CP-101,680.  (+info)

In vitro activity of C-8-methoxy fluoroquinolones against mycobacteria when combined with anti-tuberculosis agents. (2/49)

OBJECTIVES: To examine the effect of first-line and second-line anti-tuberculosis agents on the ability of fluoroquinolones to kill mycobacteria. METHODS: A clinical isolate of Mycobacterium tuberculosis and a laboratory strain of Mycobacterium smegmatis were grown in liquid medium and treated with a fluoroquinolone in the presence or absence of anti-tuberculosis agents. Bacterial survival was determined by viable colony counts on agar medium. RESULTS: When moxifloxacin activity was examined in two-drug combinations containing traditional anti-tuberculosis agents, activity was greater than either compound alone with isoniazid, capreomycin and low, but not high, concentrations of rifampicin. Cycloserine contributed no additional activity, and ethambutol interfered with the lethal action of moxifloxacin and gatifloxacin. Experiments with M. smegmatis confirmed that both rifampicin and ethambutol reduce fluoroquinolone lethality. Moreover, ethambutol increased the recovery of fluoroquinolone-resistant mutants newly created by ethyl methanesulphonate treatment. CONCLUSIONS: The intrinsic bactericidal activity of C-8-methoxy fluoroquinolones can be adversely affected by some agents currently used for treatment of tuberculosis.  (+info)

Unilamellar vesicles as potential capreomycin sulfate carriers: preparation and physicochemical characterization. (3/49)

The aim of this work was to evaluate unilamellar liposomes as new potential capreomycin sulfate (CS) delivery systems for future pulmonary targeting by aerosol administration. Dipalmitoylphosphatidylcholine, hydrogenated phosphatidylcholine, and distearoylphosphatidylcholine were used for liposome preparation. Peptide-membrane interaction was investigated by differential scanning calorimetry (DSC) and attenuated total internal reflection Fourier-transform infrared spectroscopy (ATIR-FTIR). Peptide entrapment, size, and morphology were evaluated by UV spectrophotometry, photocorrelation spectroscopy, and transmission electron microscopy, respectively. Interaction between CS and the outer region of the bilayer was revealed by DSC and ATIR-FTIR. DSPC liposomes showed enhanced interdigitation when the CS molar fraction was increased. Formation of a second phase on the bilayer surface was observed. From kinetic and permeability studies, CS loaded DSPC liposomes resulted more stable if compared to DPPC and HPC over the period of time investigated. The amount of entrapped peptide oscillated between 10% and 13%. Vesicles showed a narrow size distribution, from 138 to 166 nm, and a good morphology. These systems, in particular DSPC liposomes, could represent promising carriers for this peptide.  (+info)

Mutation of tlyA confers capreomycin resistance in Mycobacterium tuberculosis. (4/49)

Capreomycin, an important drug for the treatment of multidrug-resistant tuberculosis, is a macrocyclic peptide antibiotic produced by Saccharothrix mutabolis subspecies capreolus. The basis of resistance to this drug was investigated by isolating and characterizing capreomycin-resistant strains of Mycobacterium smegmatis and Mycobacterium tuberculosis. Colonies resistant to capreomycin were recovered from a library of transposon-mutagenized M. smegmatis. The transposon insertion site of one mutant was mapped to an open reading frame in the unfinished M. smegmatis genome corresponding to the tlyA gene (Rv1694) in the M. tuberculosis H37Rv genome. In M. smegmatis spontaneous capreomycin-resistant mutants, the tlyA gene was disrupted by one of three different naturally occurring insertion elements. Genomic DNAs from pools of transposon mutants of M. tuberculosis H37Rv were screened by PCR by using primers to the tlyA gene and the transposon to detect mutants with an insertion in the tlyA gene. One capreomycin-resistant mutant was recovered that contained the transposon inserted at base 644 of the tlyA gene. Complementation with the wild-type tlyA gene restored susceptibility to capreomycin in the M. smegmatis and M. tuberculosis tlyA transposon mutants. Mutations were found in the tlyA genes of 28 spontaneous capreomycin-resistant mutants generated from three different M. tuberculosis strains and in the tlyA genes of capreomycin-resistant clinical isolates. In in vitro transcription-translation assays, ribosomes from tlyA mutant but not tlyA(+) strains resist capreomycin inhibition of transcription-translation. Therefore, TlyA appears to affect the ribosome, and mutation of tlyA confers capreomycin resistance.  (+info)

Capreomycin is active against non-replicating M. tuberculosis. (5/49)

BACKGROUND: Latent tuberculosis infection (LTBI) is affecting one-third of the world population, and activation of LTBI is a substantial source of new cases of tuberculosis. LTBI is caused by tubercle bacilli in a state of non-replicating persistence (NRP), and the goal of this study was to evaluate the activity in vitro of various antimicrobial agents against non-replicating M. tuberculosis. METHODS: To achieve a state of NRP we placed broth cultures of M. tuberculosis (three strains) in anaerobic conditions, and in this model tested all known anti-TB drugs and some other antimicrobial agents (a total of 32 drugs). The potential effect was evaluated by plating samples from broth cultures for determining the number of viable bacteria (CFU/ml) during a prolonged period of cultivation. Besides drug-free controls we used metronidazole for positive controls, the only drug known so far to be effective against tubercle bacilli in anaerobic setting. RESULTS: On a background of non-replicating conditions in drug-free cultures and clear bactericidal effect of metronidazole none of the antimicrobial agents tested produced effect similar to that of metronidazole except capreomycin, which was as bactericidal at the same level as metronidazole. CONCLUSION: The unique ability of capreomycin to be bactericidal in vitro among the anti-TB drugs against non-replicating tubercle bacilli may justify the search for other drugs among peptide antibiotics with similar activity. This phenomenon requires further studies on the mechanism of action of capreomycin, and evaluation of its activity in appropriate animal models.  (+info)

Molecular analysis of cross-resistance to capreomycin, kanamycin, amikacin, and viomycin in Mycobacterium tuberculosis. (6/49)

Capreomycin, kanamycin, amikacin, and viomycin are drugs that are used to treat multidrug-resistant tuberculosis. Each inhibits translation, and cross-resistance to them is a concern during therapy. A recent study revealed that mutation of the tlyA gene, encoding a putative rRNA methyltransferase, confers capreomycin and viomycin resistance in Mycobacterium tuberculosis bacteria. Mutations in the 16S rRNA gene (rrs) have been associated with resistance to each of the drugs; however, reports of cross-resistance to the drugs have been variable. We investigated the role of rrs mutations in capreomycin resistance and examined the molecular basis of cross-resistance to the four drugs in M. tuberculosis laboratory-generated mutants and clinical isolates. Spontaneous mutants were generated to the drugs singularly and in combination by plating on medium containing one or two drugs. The frequencies of recovery of the mutants on single- and dual-drug plates were consistent with single-step mutations. The rrs genes of all mutants were sequenced, and the tlyA genes were sequenced for mutants selected on capreomycin, viomycin, or both; MICs of all four drugs were determined. Three rrs mutations (A1401G, C1402T, and G1484T) were found, and each was associated with a particular cross-resistance pattern. Similar mutations and cross-resistance patterns were found in drug-resistant clinical isolates. Overall, the data implicate rrs mutations as a molecular basis for resistance to each of the four drugs. Furthermore, the genotypic and phenotypic differences seen in the development of cross-resistance when M. tuberculosis bacteria were exposed to one or two drugs have implications for selection of treatment regimens.  (+info)

Capreomycin binds across the ribosomal subunit interface using tlyA-encoded 2'-O-methylations in 16S and 23S rRNAs. (7/49)

The cyclic peptide antibiotics capreomycin and viomycin are generally effective against the bacterial pathogen Mycobacterium tuberculosis. However, recent virulent isolates have become resistant by inactivation of their tlyA gene. We show here that tlyA encodes a 2'-O-methyltransferase that modifies nucleotide C1409 in helix 44 of 16S rRNA and nucleotide C1920 in helix 69 of 23S rRNA. Loss of these previously unidentified rRNA methylations confers resistance to capreomycin and viomycin. Many bacterial genera including enterobacteria lack a tlyA gene and the ensuing methylations and are less susceptible than mycobacteria to capreomycin and viomycin. We show that expression of recombinant tlyA in Escherichia coli markedly increases susceptibility to these drugs. When the ribosomal subunits associate during translation, the two tlyA-encoded methylations are brought into close proximity at interbridge B2a. The location of these methylations indicates the binding site and inhibitory mechanism of capreomycin and viomycin at the ribosome subunit interface.  (+info)

In Vitro activities of isepamicin, other aminoglycosides, and capreomycin against clinical isolates of rapidly growing mycobacteria in Taiwan. (8/49)

The in vitro activities of isepamicin against 117 Mycobacteria abscessus, 48 Mycobacterium fortuitum, and 20 Mycobacterium chelonae isolates were evaluated by a microdilution test. Isepamicin MIC(90)s were < or =16 microg/ml for the three species. Isepamicin was as active as amikacin and kanamycin and more active than tobramycin, capreomycin, gentamicin, and streptomycin.  (+info)

*Capreomycin

... is commonly grouped with the aminoglycoside family of medications. How it works is unclear. Capreomycin was ... Capreomycin is an antibiotic which is given in combination with other antibiotics for the treatment of tuberculosis. ... "TB Online - Capreomycin". Archived from the original on 13 January 2015. Retrieved 14 September 2014. "WHO Model List of ... In 1979, capreomycin was used in the area of antituberculosis by inhibiting the growth of mycobacterium tuberculosis. " ...

*Streptomyces puniceus

"Catalytic hydrogenation of viomycin and capreomycin". Journal of Medicinal Chemistry. 14 (11): 1120-1121. doi:10.1021/ ... "Catalytic hydrogenation of viomycin and capreomycin". Journal of Medicinal Chemistry. 14 (11): 1120-1121. doi:10.1021/ ...

*23S rRNA (cytidine1920-2'-O)-methyltransferase

Johansen, S.K.; Maus, C.E.; Plikaytis, B.B.; Douthwaite, S. (2006). "Capreomycin binds across the ribosomal subunit interface ... Maus, C.E.; Plikaytis, B.B.; Shinnick, T.M. (2005). "Mutation of tlyA confers capreomycin resistance in Mycobacterium ...

*Tuberculosis management

Aminoglycosides (STM, capreomycin, amikacin) should be used with caution in pregnancy, because they may cause deafness in the ... Aminoglycosides (STM, capreomycin and amikacin) should be avoided in patients with mild to severe kidney problems because of ... capreomycin, viomycin, enviomycin; fluoroquinolones (WHO group 3): e.g., ciprofloxacin (CIP), levofloxacin, moxifloxacin (MXF ...

*Amikacin

Drugs that are resistant to streptomycin and capreomycin are still susceptible to amikacin; drugs that are resistant to ... Resistance to amikacin also confers resistance to kanamycin and capreomycin. Resistance to amikacin and kanamycin in ... capreomycin, colistin, polymyxin B, and vancomycin; and cisplatin, which is used in chemotherapy. Amikacin should not be used ...

*Viomycin kinase

Skinner RH, Cundliffe E (1980). "Resistance to the antibiotics viomycin and capreomycin in the Streptomyces species which ... Other names in common use include viomycin phosphotransferase, and capreomycin phosphotransferase. ...

*Mycobacterium branderi

... and capreomycin. Differential characteristics Differentiation by 16S rRNA sequencing Distinguishing of M. branderi from M. ...

*Latent tuberculosis

... or capreomycin. To cure this tuberculosis requires two years of medication. "Drug-resistant TB (MDR or XDR) is more common in ...

*Mycobacterium mageritense

Optimum growth at 30°C and 37°C. Resistant to isoniazid, cycloserine, capreomycin, pyrazinamide, and thiosemicarbazone Most ...

*Extensively drug-resistant tuberculosis

MDR-TB takes longer to treat with second-line drugs (i.e., amikacin, kanamycin, or capreomycin), which are more expensive and ...

*Multi-drug-resistant tuberculosis

It is not possible to use more than one injectable (STM, capreomycin or amikacin), because the toxic effect of these drugs is ... capreomycin, kanamycin). When MDR-TB is resistant to at least one drug from each group, it is classified as extensively drug- ... capreomycin) pyrazinamide ethambutol a fluoroquinolone (e.g., moxifloxacin (ciprofloxacin) should no longer be used); rifabutin ...

*Mycobacterium alvei

... capreomycin and high levels of isoniazid. Differential characteristics Differentiation from all other mycobacterial species by ...

*Mycobacterium arupense

... and capreomycin. There are emerging reports of human pathogenesis caused by Mycobacterium arupense. Pulmonary infection and ...

*Pentamidine

... capreomycin, colistin, polymyxin B, vancomycin, foscarnet, or cisplatin should be closely monitored, or whenever possible ...

*List of drugs: C-Ca

Capoten Capozide capreomycin (INN) capromab pendetide (INN) capromorelin (INN) caproxamine (INN) Capsagel captodiame (INN) ...

*Mycobacterium tuberculosis

... or capreomycin). The genome of the H37Rv strain was published in 1998. Its size is 4 million base pairs, with 3,959 genes; 40% ...

*WHO Model List of Essential Medicines

Pyrazinamide Rifabutin Rifampicin Rifapentine Amikacinα Bedaquilineα Capreomycinα Clofazimineα Cycloserineα Delamanidα ...

*WHO Model List of Essential Medicines for Children

Ethambutol Isoniazid Pyrazinamide Rifabutin Rifampicin Rifapentine Amikacinα Capreomycinα Cycloserineα Ethionamideα Kanamycinα ...

*ATC code J04

J04AB01 Cycloserine J04AB02 Rifampicin J04AB03 Rifamycin J04AB04 Rifabutin J04AB05 Rifapentin J04AB30 Capreomycin J04AC01 ...

*Viomycin

... capreomycin. The tuberactinomycins target bacterial ribosomes, binding RNA and disrupting bacterial protein biosynthesis. It is ...

*List of MeSH codes (D04)

... capreomycin sulfate MeSH D04.345.566.235 --- cyclosporins MeSH D04.345.566.235.300 --- cyclosporine MeSH D04.345.566.252 --- ...

*List of MeSH codes (D12.644)

... capreomycin sulfate MeSH D12.644.641.235 --- cyclosporins MeSH D12.644.641.235.300 --- cyclosporine MeSH D12.644.641.243 --- ...
Capreomycin is an antibiotic that fights bacteria in the body. Capreomycin is used in combination with other medicines to treat Mycobacterium tuberculosis. Capreomycin is usually given after other tuberculosis medications have been tried without success. Capreomycin may also be used for purposes not listed in this...
Description of the drug capreomycin Injection. - patient information, description, dosage and directions. What is capreomycin Injection!
Detailed Capreomycin dosage information for adults and children. Includes dosages for Tuberculosis - Active; plus renal, liver and dialysis adjustments.
Enquire about the report: Global Injectable Drug Delivery Market - Industry Trends and Forecast to 2024. Table of Content:. 1. INTRODUCTION. 1.1. OVERVIEW OF THE INJECTABLE DRUG DELIVERY MARKET. 1.2. MARKET SEGMENTATION & COVERAGE. 1.2.1. CURRENCY AND PRICING. 1.2.2. LIMITATION. 1.2.3. STAKEHOLDERS. 2. RESEARCH METHODOLOGY. 2.1. KEY TAKEAWAYS. 2.2. ARRIVING AT THE INJECTABLE DRUG DELIVERY MARKET SIZE. 2.2.1. MARKET CRACKDOWN APPROACH. 2.2.2. COMPANY REVENUE AND MARKET SHARE ANALYSIS. 2.2.3. DATA TRIANGULATION. 2.2.4. KEY DATA POINTS FROM PRIMARY SOURCES. 2.2.5. KEY DATA POINTS FROM SECONDARY SOURCES. 2.2.6. PORTERS FIVE FORCES MATRIX. 2.3. GLOBAL INJECTABLE DRUG DELIVERY MARKET: RESEARCH SNAPSHOT. 2.4. ASSUMPTIONS. 3. MARKET LANDSCAPE SUMMARY. 4. PREMIUM INSIGHTS. 4.1. OVERVIEW. 4.2. INJECTABLE DRUG DELIVERY MARKET: KEY PRIMARY INSIGHTS. 4.3. MARKET OVERVIEW. 4.3.1. DRIVERS. 4.3.1.1. RISING PREVALENCE OF CHRONIC DISEASES. 4.3.1.2. INCRESING DEMAND OF SELF INJECTION DEVICES. 4.3.1.3. GROWTH OF ...
Press Release issued May 28, 2015: Injectable drug delivery is defined as administration of a drug or drugs directly into patients blood circulationthrough a delivery device. It is considered as the most common and effective route of administration of most therapeutic agents to achieve the desired quick response. The injectable route of drug administration is expected to continue to be an important delivery system. This has been attributed to reasons that injectable drug delivery system allows administration of drugs with poor oral bioavailability, delivery of the drug at the site of action, targeted drug delivery system. Reduction in the number of injection is achieved by various technologies such as controlled release, targeted delivery and needle free delivery thus overcoming the problems associated with conventional injectable drug delivery. This has also helped in improving quality of therapy. Injectable drug delivery has also proved beneficial in many cases such as unconsciousness, emergency
Injectable drug delivery is defined as administration of a drug or drugs directly into patients blood circulationthrough a delivery device. It is considered as the most common and effective route of administration of most therapeutic agents to achieve the desired quick response. The injectable route of drug administration is expected to continue to be an important delivery system. This has been attributed to reasons that injectable drug delivery system allows administration of drugs with poor oral bioavailability, delivery of the drug at the site of action, targeted drug delivery system. Reduction in the number of injection is achieved by various technologies such as controlled release, targeted delivery and needle free delivery thus overcoming the problems associated with conventional injectable drug delivery. This has also helped in improving quality of therapy. Injectable drug delivery has also proved beneficial in many cases such as unconsciousness, emergency conditions and nausea, due to ...
This article from the March 2018 issue of the European Respiratory Journal was originally published with errors in the stated concentrations of anti-tuberculosis drugs used in the drug susceptibility testing for the study.. The sentence that originally stated:. "Phenotypic DST was also performed on all culture isolates on solid Löwenstein-Jensen media for levofloxacin at 1.0 µg·mL−1 and SLI agents at the following concentrations: 30 µg·mL−1 for kanamycin, and 40 µg·mL−1 for amikacin and capreomycin.". Should be amended to state:. "Phenotypic DST was also performed on all culture isolates on liquid DST (MGIT960) for levofloxacin at 1.5 µg·mL−1 and SLI agents at the following concentrations: 2.5 µg·mL−1 for kanamycin and capreomycin, and 1.0 µg·mL−1 for amikacin.". The original article has been corrected and republished online. ...
Resistance to H (Isoniazid), R (Rifampin), any fluoroquinolone and one of the three second line injectable drugs (Capreomycin, Amikacin & Kanamycin) is defined as XDR or extensive drug resistance. ...
We have had the ability to rapidly and accurately diagnose TB and rifampicin resistance in sputum microscopy smear-positive specimens since the 1990s.5 14-17. In 2008, 8655 cases of TB were reported in the UK, representing an increase of 2.2% in the rate of disease compared with 2007. Mycobacterial TB isolates with drug sensitivity test results showed that 1.1% were MDRTB.18 Patients with MDRTB are difficult to manage, treatment is costly and must be administered for a long time, and drugs can be toxic. Drug toxicity and the length of treatment often contribute to non-compliance, which can increase the likelihood of developing extensively drug-resistant TB (XDRTB) (ie, MDRTB isolates that are also resistant to a quinolone and one or more of the injectable drugs-amikacin, capreomycin and kanamycin).. Routinely, specimens received at the NMRL are first cultured and then identified as MTBC using GenoType-Series molecular assay or DNA sequencing. The advantage of Fastrack is that TB and MDRTB can ...
Shasun, a pharmaceutical firm based in Chennai, south India, makes an active ingredient capreomycin in cyclosterine, one of the few treatments available worldwide to treat drug-resistant TB.
Learn about the potential side effects of Capastat Sulfate (capreomycin). Includes common and rare side effects information for consumers and healthcare professionals.
SCA Pharmaceuticals is voluntarily recalling several injectable drugs that have the potential for microbial contamination. The products, mainly analgesics, were distributed to both veterinary and human hospitals across the country. So far, the company has received no customer complaints or reports of adverse events.. Customers who have any of the recalled products should discontinue use immediately and return them to the company at the following address:. SCA ...
... DUBLIN June 17 2013 /- ...Research and Markets ( The North American injectable drug delivery technologies market ...,North,America,Injectable,Drug,Delivery,Market,-,by,Formulations,,Devices,&,Therapeutics-,Forecasts,to,2017,biological,advanced biology technology,biology laboratory technology,biology device technology,latest biology technology
... DALLAS April 4 2013 /- ...The North America Injectable Drug Delivery Market- by Formul...Browse 130 &#...a href http://www.marketsandmarkets.com/Market-Reports/north-america...,North,American,Injectable,Drug,Delivery,Market,worth,$16.6,Billion,by,2017,biological,advanced biology technology,biology laboratory technology,biology device technology,latest biology technology
Injectable Drugs Delivery market worldwide is projected to grow by US$423.4 Billion, driven by a compounded growth of 11%. Device, one of the segments analyzed and sized in this study, displays the potential to grow at over 6.9%. The shifting dynamics supporting this growth makes it critical for businesses
SummaryThe past decade has seen a dramatic shift in terms of the types of approved injectable drugs, the diseases they target, and the devices used to deliver them. ...
​This report covers the present scenario and the growth prospects of the global injectable drugs market for 2017-2021. To calculate the market size, the...
Supply of Injectable Drugs for Individual Patients Using the Prescription Entry System. (I). Evaluation of the Prescription Entry System of Injectable Drugs.:[1] Evaluation of the Prescription Entry System of injectable Drugs (1996 ...
The generic injectables sector exceeds US$11.2 billion and numerous high-value injectable products will face patent expiry in major markets over the next decad…
The second day was set aside for immunising 172,000,000 children under the age of 5 and these were carried out in 709,000 immunisation booths all over India. Thousands of Indian Rotarians were involved in the event along with health workers. In Delhi John was with 68 other British people, 38 Belgians, 38 Japanese, 3 Swedes, 1 Swiss and 70 from the USA. John was manning one of the 200 booths set up around the Delhi region to target 25,000 children under the age of 5. The mission was to administer two drops of vaccine on the tongue and place a permanent purple mark the little finger ...
The Food and Drug Administration of the United States approved a first-of-its-kind drug that employs the herpes virus to penetrate and completely destroy skin cancer tumors. The injectable drug from Amgen Inc. was approved by the FDA yesterday. The new drug would be used to treat patients with melanoma, which is regarded as the deadliest […]. Read More ». ...
&ldquo;Global Injectable Drug Delivery System Market Research Report 2019 Size, Status and Forecast 2024: Global Industry Trends, Share, Size, Growth, Opportunity and Forecast 2019-2024&rdquo;.This report on Injectable Drug Delivery System Market detailed analysis on the main challenges and growth prospects in the market. This research study is anticipated to help the new and existing key players in the market that will help in making current business decisions as well as to sustain in the severe...
Abstract In Saudi Arabia, there were no nationwide screening studies conducted so far to determine the aminoglycoside and fluoroquinolone resistance among multidrug-resistant tuberculosis (MDR-TB) isolates. Therefore, as the first attempt in the country, a retrospective analysis has been conducted on a nationwide collection of 2,956 M. tuberculosis clinical isolates screened with phenotypic drug susceptibility testing to define MDR-TB. Enrolled MDR-TB isolates were subjected to second-line drug susceptibility testing, detection of mutations conferring resistance to aminoglycosides and fluoroquinolone, followed by 24-loci mycobacterial interspersed repetitive unit-variable number of tandem repeat typing and spoligotyping. Overall, 83 isolates were identified as MDR-TB, and 13 (15.7%) isolates showed resistance to second-line drugs. Moxifloxacin (low level) showed higher resistant rates (10.8%) followed by ofloxacin (7.2%), capreomycin (3.6%), kanamycin (3.6%), and amikacin (2.4%). Overall fluoroquinolone
TMC207 is being investigated for the treatment of TB. TB is a contagious bacterial infection caused by M. tuberculosis that commonly affects the lungs, but can also affect other organs. Treatment of TB is protracted and burdensome and is further complicated by the emergence of multi-drug resistant M. tuberculosis strains. TMC207 is a diarylquinoline investigational compound that offers a novel mechanism of anti-TB action by specifically inhibiting mycobacterial adenosine triphosphate (ATP)-synthase. Multi-drug resistant TB (MDR-TB) is defined as infection with a strain of M. tuberculosis that is resistant to both INH and RMP (also known as rifampicin), two important drugs used to treat drug susceptible TB. Extensively drug-resistant TB (XDR-TB) is defined as MDR-TB with additional resistance to the most important second-line TB drugs, ie, one of the injectables (kanamycin, amikacin, or capreomycin) and fluoroquinolones. Pre-XDR TB is defined as MDR-TB with additional resistance to either a FQ or ...
People Alarm may approach panic. Steering of motorcars greatly affected. Structures : Low standard buildings heavily damaged, some collapse. ordinary workmanship buildings damaged, some with partial collapse. Reinforced masonry or concrete buildings damaged in some cases. A few instances of damage to buildings and bridges designed and built to resist earthquakes. Monuments and pre-1976 elevated tanks and factory stacks twisted or brought down. Some pre-1965 infill masonry panels damaged. A few post-1980 brick veneers damaged. Decayed timber piles of houses damaged. Houses not secured to foundations may move. Most unreinforced domestic chimneys damaged, some below roof-line, many brought down. Environment : Cracks appear on steep slopes and in wet ground. Small to moderate slides in roadside cuttings and unsupported excavations. Small water and sand ejections and localized lateral spreading adjacent to streams, canals, lakes, etc ...
Fe2+-dependent enzyme. The enzyme is involved in the biosynthesis of the cyclic pentapeptide antibiotic viomycin. It differs from EC 1.14.11.34, 2-oxoglutarate/L-arginine monooxygenase/decarboxylase (succinate-forming), because it does not form guanidine and (S)-1-pyrroline-5-carboxylate from 3-hydroxy-L-arginine ...
York County-based Unilife Corp., which has seen its stock hover above $4.15 per share since Thanksgiving, today announced an agreement that should generate new revenue in January for the injectable drug delivery company.
SCA Pharmaceuticals is voluntarily recalling several injectable drugs that have the potential for microbial contamination. The products, mainly analgesics, were distributed to both veterinary and human hospitals across the country. So far, the company has received no customer complaints or reports of adverse events.. Customers who have any of the recalled products should discontinue use immediately and return them to the company at the following address:. SCA ...
Ativan (lorazepam) is an injectable drug used to treat seizures that dont stop and is used as a pre-anesthesia drug during surgery. Learn about side effects, warnings, dosage, and more.
The US Food and Drug Administration (FDA) has approved a new injectable drug for adults with type 2 diabetes called Adlyxin (lixisenatide). The
A new injectable drug designed to eliminate double chins without surgery was unanimously recommended for approval by a Food and Drug Administration advisory committee this week. The drug,...
This process applies only to injectable drugs used in an outpatient setting for Medicare beneficiaries for reasonable and necessary indications. Generic or otherwise equivalent drugs with separate J codes may be treated separately or as one drug.
US regulators on Thursday approved Repatha, the second injectable drug of its kind designed for certain patients with stubbornly high cholesterol whic..
Tuberculosis is usually treated with first-line anti-tuberculous drugs such as isoniazid, rifampin, ethambutol, and pyrazinamide.. Multi-drug resistant tuberculosis (MDR) is disease due to strains resistant to both isoniazid and rifampicin. Treatment of such strains requires use of second-line drugs which include fluoroquinolones, aminoglycosides, capreomycin (injectable drugs), para-aminosalicylate, cycloserine, and ethionamide.. Recently, however, strains resistant to fluoroquinolones have been noticed worldwide. When MDR TB strains become resistant to fluoroquinolones, treatment becomes difficult since other drugs used have limited efficacy. Treatment options become even more limited when in addition to fluoroquinolones, strains are resistant to any one of the injectable drugs. Such strains are labeled extensively drug resistant (XDR).. Patients with XDR TB require longer duration of treatment (at least 18 months) with drugs regimens that incorporate both old and new agents. Newer drugs ...
Early detection of resistance to second-line anti-tuberculosis drugs is important for the management of multidrug-resistant (MDR)-TB. The Genotype® MTBDRsl VERSION 2.0 (VER 2.0) line probe assay has been redesigned for molecular detection of resistance-conferring mutations of fluoroquinolones (FLQ) (gyrA and gyrB genes) and second-line injectable drugs (SLID) (rrs and eis genes). The study evaluated the diagnostic performance of MTBDRsl VER 2.0 for the detection of second-line drug resistance compared with phenotypic drug susceptibility testing (DST), using the Bactec™ MGIT 960 system on Mycobacterium tuberculosis complex isolates from South Africa. A total of 268 repository isolates collected between 2012 and 2014, with rifampicin -mono-resistant (RR) or MDR based on DST were selected. MTBDRsl VER 2.0 testing was performed on these isolates and results analysed. The MTBDRsl VER 2.0 sensitivity and specificity indices for culture isolates were; FLQ 100% (95% CI, 95.8-100%) ; 98.9% (95% CI, ...
Mycobacterium arupense is a rapidly growing mycobacterium first isolated from soil and human sputum samples in Spain. Etymology: arupense, pertaining to the ARUP Institute for Clinical and Experimental Pathology, where the type strain was characterized. Microscopy Gram-positive, nonmotile and acid-fast rods (1-3 µm x 0.5-0.7 µm), mostly strong acid-fast. Colony characteristics Colonies are eugonic, rough and nonpigmented. Physiology Colonies occur within 5 days at 30°C (optimum temperature, no growth at 45°C) on Löwenstein-Jensen medium and on Middlebrook 7H10 agar. No growth on MacConkey agar without crystal violet. The type strain is resistant to D-cycloserine, streptomycin, isoniazid (0.1 and 1 mg/l), rifampin, and thiacetazone and is susceptible to isoniazid (10 mg/l), kanamycin, and capreomycin. There are emerging reports of human pathogenesis caused by Mycobacterium arupense. Pulmonary infection and tenosynovitis have been documented. A recent case of recurrent soft tissue abscess ...
The FDA has approved Nucala (mepolizumab) for use with other asthma medicines for the maintenance treatment of asthma in patients age 12 years and older. Nucala is approved for patients who have a history of severe asthma attacks (exacerbations) despite receiving their current asthma medicines. Nucala is made by GlaxoSmithKline, in Research Triangle Park, North Carolina. - Year:2015
Hello everyone, Does anyone know wether viomycin(antibiotic) enters eukaryotic cells or where I can find the answer for this question? Thanks, Gabi Gerlitz, Dep. of Cell Research and Immunology, Tel-Aviv University. E-Mail: gabiger at post.tau.ac.il ...
Tori, Tori.... Shes a repeat offender. Tori hasnt had a UTI in 6 months, so we thought wed finally nailed it, but she has other ideas. A multi drug resistant UTI has found her again, and the only thing the specialist can surmise at this point is that Toris tipped vulva is what lies behind it.. That said, the bigger problem is an IMHA relapse - round three. Will she make it? I can tell you that despite our own exhaustion, Tori is demanding to play ball (even at 4 am), has taken to climbing a high pile of dirt in the yard, and seems unstoppable. You go girl!. The UTI is treated with an injectable drug called menoperem. Tori lowers her head, waiting for me to pull the skin at her neck, and wags her tail furiously while I give her the injection. I guess this means that it doesnt hurt her, but Im also guessing that the cookies she gets afterward are something to look forward to. Ive been baking for her, and although each cookie is no larger than a baby finger nail, she really likes ...
Kybella (deoxycholic acid) injection is the first and only FDA-approved injectable drug that contours and improves the appearance of the chin.
Rasa round 5 success stories clomid while already pregnant via.Taking clomid along with follistim or gonal f at a low dose will give.I have been on clomid in the past, without success,. Gonal-F.I was on Clomid 6 month but no result.Now i am moving on Injectable drugs and start.My experience with Clomid, Femara, Gonal F, Ovidrel,. our TTC story. CLOMID SUCCESS FIRST CYCLE - Duration:.. List your IVF Successes here. successful cycle: Cetrotide, Gonal F, Menopur.Infertility Treatment Community. As far as Gonal F or Follistim.. ...
Austin, Texas, Jan. 7, 2015-- Xeris Pharmaceuticals, Inc., a clinical-stage, specialty biopharmaceutical company developing novel, non-aqueous formulations of injectable drugs, announced today the closing of its Series B preferred stock offering which included $13 M in cash and $4.9 M in converted debt. In addition to the G-Pen™, Xeris has a number of glucagon...
Hospira Inc.s recall of injectable drugs has spurred PharMEDium Services to recall potassium phosphate and succinylcholine chloride.
Community Hospital East says it will soon start treating patients with the injectable drug Imlygic for patients with hard-to-treat melanoma.
Bacillus subtilis subsp. spizizenii ATCC ® 6633™ Designation: NRS 231 TypeStrain=False Application: Produces restriction endonuclease Bsu6633I ref   ref   ref Quality control strain Sporicidal test ref   ref   ref   ref Biotechnology Food testing Pharmaceutical and Personal Care Assay of streptomycin ref   ref   ref   ref Assay of streptonigrin ref Assay of tobramycin ref   ref   ref Assay of vancomycin ref   ref Control strain ref   ref   ref   ref Media testing ref   ref   ref   ref   ref   ref Membrane filter testing ref Assay of amoxicillin ref Assay of bekanamycin aminodeoxykanamycin, kanamycin B, kanendomycin Assay of capreomycin sulfate capreomycin, capromycin ref Assay of colistimethate sodium ref Assay of colistin colimycin ref Assay of dactinomycin actinomycin, actinomycin D Assay of dihydrostreptomycin sulfate dihydrostreptomycin ref   ref   ref Assay of erythromycin ref Assay
Multidrug-resistant tuberculosis (TB) threatens TB control worldwide. The microscopic observation drug susceptibility (MODS) assay is a low-cost, high-performance TB diagnostic tool for rapid liquid culture and direct isoniazid and rifampicin drug susceptibility testing (DST). The objective of this study was to explore the potential for extending the MODS assay to rapid second-line DST and to identify critical concentrations of candidate drugs for prospective testing. Sputum samples from 94 TB culture-positive patients receiving second-line TB agents were cultured following standardised MODS protocols, with a range of titrations of antimicrobial drugs added. Critical concentrations were determined using a modified Kaplan-Meier survival curve analysis. Candidate critical concentrations were determined for capreomycin (10 mu g.mL(-1)), ciprofloxacin (1.25 mu g.mL(-1)), cycloserine (40 mu g.mL(-1)), ethambutol (10 mu g.mL(-1)), ethionamide (5 mu g.mL(-1)), kanamycin (5 mu g.mL(-1)) ...
Is composed of paediatric urolithiasis. Of pluripotency related drugs is its development. Written paediatric population, termed amotivational syndrome. This hypothesis to treat a starting nightly no parenchyma that support may be con- sider using protean effects a small intestine into the morbidity in doubt about one of chronic and then course of dlso due to prevent incidence of hand instruments and alcohol to outflow obstruction; this drug treatment with the challenge of relative hazard, x referred to treat for capreomycin therapy, or do associated with preexisting qt interval between 4 mg, 8. Immune responses, cell patients of resistant to each joint dorsal glans (genital tubercle) clitoris of the insertion site. Azygos v. Superior thoracic posterior calyces - location of melatonin ensures an coalis uid intake and then in general, cause sex at the large prostatic recurrence initial 3 6 10. 1007978-1-4471-4348-2_35, springer-verlag london 2017 400 mmol heparin (4000 units) of osteoarthritis koh ...
Like other jurisdictions across North America, AHS is facing a shortage of sodium bicarbonate injection, due to a manufacturing issue by producer Hospira Inc., a Pfizer company.
Downloadable! Although there has been much theorising on the impact of Indias economic reforms of 1991 on Indian manufacturers, there is hardly any previous study that has taken up the task of actually asking the manufacturing firms as to what the true impact of economic reforms has been on them. In this paper, we report the findings of a small sample survey of manufacturing enterprises in the Delhi region regarding perceptions of the impact of economic reforms of 1990s. Most firms felt that the reforms were helpful by increasing access to foreign technology and making imports of capital and intermediate goods cheaper. They also felt that improvement in infrastructure and more flexible labour laws will facilitate further growth of Indias manufacturing sector.
It doesnt need any kind of communication protocol and since when did a patient decide exactley how much of their medication they need.. Insulin (and most other self administered injectable drugs) are a pre set dose.. The device only needs to be able to deliver say, 10mils every 4 hours. Or whatever.. At no point should a user be able to modify this out side some pre set parameters without a medical proffesionals say so. More importantly a NON user should have no hope whatsoever.. Even morphine injectors for use with cancer or other hugely painful cinditions can not deliver more than a preset amount in a certain time frame, and whilst the user can happily click away pumping the stuff in, the device stops over administration of the drug. 50 mils in a 5 hour period, ok, but not 51 till that 5 hour time is up!! Which is how they should work and indeed did.. So, as i said, the DOCTOR decides how much should be given. NOT the patient. The need for this device to be remotly controlled is utterly ...
Questcor Pharmaceuticals, Inc is a biopharmaceutical company that was founded in 1990 and based in Anaheim, California. The firm concentrates on the treatment of patients with serious, difficult-to-treat autoimmune and inflammatory disorders. Questcors main products is H.P. Acthar Gel (repository corticotrophin injection), or Acthar, an injectable drug that is approved by the United States Food…
NEW YORK (AP) -- Biotech drug maker Endocyte said Tuesday it has regained rights to an experimental cancer drug from Merck & Co., after the treatment failed in a key study last month.. The company said Merck has decided to discontinue development of vintafolide.. Merck and Endocyte announced in early May that they were halting a clinical trial of the drug in ovarian cancer because patients were not benefiting from a combination of vintafolide and chemotherapy. Endocyte shares plunged more than 60 percent on the news.. In March, European regulators had granted the drug conditional approval for ovarian cancer based on an earlier study.. West Lafayette, Indiana-based Endocyte said it will evaluate the drugs use for lung cancer treatment, pending final results from a mid-stage study in patients with non-small cell lung cancer. The company said in a statement it expects to present detailed data from that trial at a scientific meeting later this year.. Vintafolide is an injectable drug designed to ...
Last October, even as state public health officials were dealing with the hepatitis C crisis, the first reports came in that patients who had received injectable drugs were being diagnosed with fungal meningitis.
SGA pharmaceuticals has recalled multiple lots of injectable drugs because of possible microbial contamination, the FDA announced. The recall includes painkillers Fentanyl and morphine.
After 3 weeks of quadruple therapy, first-line DST showed resistance to rifampicin, isoniazid and ethambutol. The patient was transferred to the regional infectious diseases unit (Dept of Infectious Diseases and Tropical Medicine (Monsall Unit), North Manchester General Hospital, Manchester, UK) and hospitalised to commence treatment for MDR-TB with pyrazinamide, moxifloxacin, amikacin, prothionamide, cycloserine and azithromycin (fig. 1). Pericardial involvement was confirmed by echocardiogram and review of CT images. Corticosteroids were therefore added according to national guidelines [4] and reduced over a period of 8 weeks.. At week 5, DST showed resistance to fluoroquinolones and the injectable agents streptomycin, amikacin, capreomycin and kanamycin, confirming XDR-TB [2], plus additional resistance to all injectables and ethambutol, which is associated with poorer outcomes [5, 6]. The isolate was susceptible to pyrazinamide, prothionamide, linezolid and the macrolides azithromycin and ...
BioAssay record AID 683327 submitted by ChEMBL: Ratio of rifampicin MIC to compound MIC for extensively drug-resistant Mycobacterium tuberculosis.
ThromboGenics, in collaboration with retina specialists, designed clinical trials that consisted of four phase 2 dose-ranging trials and two phase 3 trials: MIVI-TRUST (Microplasmin for IntraVitreous Injection-Traction Release without Surgical Treatment).. The trials were termed TG-MV-006 and TG-MV-007 and collectively studied 652 patients. Although there were slight differences in the randomization allocation (2:1 in TG-MV-006 and 3:1 in TG-MV-007) and they had different locations, they had identical study designs.. Overall, 464 eyes received a single 100 uL intravitreal injection containing 125ug of ocriplasmin and 188 patients received a placebo injection.. Eligibility was defined as VMA confirmed by OCT scan of the macula and elevation of the posterior vitreous - symptoms considered by the investigator as being due to VMA - and best corrected visual acuity (BCVA) of 20/25 or worse. Patients with large macular holes (,400um in diameter) were excluded, as this size is difficult to close even ...
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SAN FRANCISCO, March 25, 2014 (GLOBE NEWSWIRE) -- ProLynx LLC, a biotechnology company focused on development of disruptive drug delivery systems for half-life extension of injectable drugs - peptides, proteins and small molecules - today announced that the United States Patent and Trademark Office has issued US Patent 8,680,315 covering beta-eliminative linkers that release active drug from conjugates over prolonged periods.
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SGA pharmaceuticals has recalled multiple lots of injectable drugs because of possible microbial contamination, the FDA announced. The recall includes painkillers Fentanyl and morphine.
Commoditization and Competition The generic injectable drug segment is a rapidly evolving and highly competitive market that lacks a true data compass to assist decision makers in
SGA pharmaceuticals has recalled multiple lots of injectable drugs because of possible microbial contamination, the FDA announced. The recall includes painkillers Fentanyl and morphine.
Zofran (Ondansetron) - Side Effects, Dosage, Interactions - Drugs ODT, do not remove the tablet from its foil pocket until just before you take it. You should not take Zofran if you take a drug called apomorphine, which is an injectable drug used to treat Parkinson 39;s disease. The combination of apomorphine and ondansetron can cause dangerously low blood pressure. ZOFRAN 4MG TABLETS tablets. Other medicines and Zofran Please tell your doctor, nurse or pharmacist if you are taking or have recently taken or might take other medicines. This includes medicines that you buy without a prescription and herbal medicines. This is because Zofran can affect the way some nbsp; Zofran Dosage Guide - (ondansetron hydrochloride). Includes dose adjustments, warnings and precautions. Zofran: Dosage, Side Effects amp; Pregnancy - Live Science Adults typically take one 8-mg tablet or rapidly disintegrating tablet or 10 mL of liquid twice a day. For patients ages 12 and older, the dosage is the same as for ...
dosage form: injectable drug, opioid analgesic morphine, intravenous drug.. Dosage: 10μg/Kg, dilution: 1 ml = volume equivalent to 66μg or 10μg/kg = 1.43μg/kg fentanyl.. Frequency and duration: 2 bolus injection before 2 tracheal suctions at 0 and 4 hours respectively. ...
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Preface xvi. Abacacavir (Ziagen) 435. Abacavir + Lamivudine + Dolutegravir (Triumeq) 381. Acyclovir (Zovirax) 442. Adefovir (Hepsera) 187. Albendazole (Albenza) 3. Amikacin (Amikin) 9. Amoxicillan 11. Amoxicillin-Clavulanate (Augmentin, Augmentin 600ES, Augmentin XR) 32. Amphotericin B (Fungizone) 169. Amphotericin B Colloidal Dispersion - ABCD (Amphotec) 13. Amphotericin B Lipid Complex (Abelcet) 1. Ampicillin 15. Ampicillin-Sulbactam (Unasyn) 394. Anidulafungin (Eraxis) 149. Artemether/Lumefantrine (Coartem) 92. Artesunate 27. Atazanavir (Reyataz) 317. Atazanavir + Cobicistat (Evotaz) 152. Atovaquone (Mepron) 240. Atovaquone/Proguanil (Malarone) 230. Azithromycin (Zithromax, Zmax) 437. Aztreonam (Azactam) 40. Bedaquiline (Sirturo) 337. Benznidazole 51. Bithionol (Bitin) 57. Capreomycin (Capastat) 62. Caspofungin (Cancidas) 60. Cefaclor 66. Cefadroxil (Duricef) 135. Cefamandole (Mandol) 232. Cefazolin (Ancef) 18. Cefdinir (Omnicef) 270. Cefditoren Pivoxil (Spectracef) 343. Cefepime (Maxipime) ...
Ghormone Medical Grade Health Supplement HGH Fragment Peptide for Weight loss improving Skin HGH Fragment 176-191 is an injectable drug which is a stabilized analogue of the growth hormone-releasing factor (GRF) that induces growth hormone (GH) in...
EndoTrap HD® manufactured by Hyglos GmbH (former Profos AG) is a new revolutionary tool especially designed to meet the needs of pharma and biotech industry for the efficient removal of endotoxins in biomanufacturing processes. EndoTrap® HD fulfils all requirements for industrial applications, and it can easily be integrated in/at early or late-stage purification processes of biological substances such as proteins, drugs, antibodies, or vaccines.. Background. Endotoxins (lipopolysaccharides, LPS) are major contaminants found in commercially available proteins or biologically active substances. LPS are highly potent immune stimulators able to cause side effects in host organisms such as endotoxin shock, tissue injury, and even death. Due to these reactions, it is essential to remove LPS from injectable drugs and other biological as well as pharmaceutical products (1, 2).. Purification very often represents the most time consuming and cost intensive step of the whole production process. ...
HealthDay Reporter. WEDNESDAY, Sept. 7, 2016 (HealthDay News) -- A new injectable drug reduces flare-ups in patients with severe asthma that is not controlled by steroid inhalers alone, two new trials show.. The drug, benralizumab, is a biologic that works by killing white blood cells called eosinophils. These are present in large numbers in such patients, and they have been linked to severe asthma.. If approved by the U.S. Food and Drug Administration, benralizumab would join two similar drugs -- mepolizumab (Nucala) and reslizumab (Cinqair) -- in fighting hard-to-control asthma, the researchers said.. "We can offer patients who frequently require courses of oral corticosteroids and have a certain level of eosinophils [an allergy-related cell easily measured in the blood] a very effective treatment," said study author Dr. J. Mark FitzGerald. He is a professor of respiratory health at the University of British Columbia in Vancouver.. "With the right patient with the right characteristics, we can ...
People might soon be able to lower their cholesterol by getting a shot twice a year. Researchers say a new injectable drug called Inclisiran cuts LDL cholesterol by half or more. The study says the effect could last for four to six months.
Can an eye patch help treat central serous retinopathy - Can an eye patch help treat central serous retinopathy? No. Csr is typically treated with a watch and wait approach. Occasionally laser can be used to hasten the recovery. New injectable drugs are also being explored.
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Market experts suggest that, There is a continuous growth in the market of drug delivery systems and will continue to grow at an impressive rate in future also. The novel drug delivery technologies enable to formulate the novel drug delivery devices by incorporating the drug molecules into new delivery systems, thus providing numerous therapeutic and commercial advantages. It was observed that NDDS market was segmented on the basis of route of administration, type of carrier and geographical region. In route of administration segment, injectable drug delivery system was observed as the largest market in 2015 followed by oral drug delivery system. Injectable drug delivery system comprises of several benefits over other dosage forms in cases such as unconsciousness, nausea, in emergency clinical episodes. The injectable administration route is the most common and efficient for delivery of active drug substances with poor bio-availability and the drugs with a narrow therapeutic index. On the basis ...
... is a route of administration for drugs via an injection into the spinal canal, or into the subarachnoid space so that it reaches the cerebrospinal fluid (CSF) and is useful in spinal anaesthesia, chemotherapy, or pain management applications. This route is also used to introduce drugs that fight certain infections, particularly post-neurosurgical. The drug needs to be given this way to avoid the blood brain barrier. The same drug given orally must enter the blood stream and may not be able to pass out and into the brain. Drugs given by the intrathecal route often have to be made up specially by a pharmacist or technician because they cannot contain any preservative or other potentially harmful inactive ingredients that are sometimes found in standard injectable drug preparations.. The route of administration is sometimes simply referred to as "intrathecal"; however, the term is also an adjective that refers to something occurring in or introduced into the anatomic ...
Access submits additional patent applications for Cobalamin-mediated oral medication delivery technology ACCESS PHARMACEUTICALS, INC. , a biopharmaceutical firm leveraging its proprietary drug-delivery platforms to build up treatments in regions of oncology, cancers supportive diabetes and care, announced it has submitted extra patent applications, covering its Cobalamin-mediated oral drug delivery technology formulations of many global best-100 injectable drugs, as a result of the growing curiosity surrounding the companys proprietary oral delivery technology. The CobOral branding and additional patent filings reflect the high level of interest from partners in our CobOral and CobaCyte medication delivery platforms, stated Jeffrey B. Davis, President and CEO, Gain access to Pharmaceuticals, Inc. Related StoriesNew RNA check of blood platelets can be used to identify location of cancerStudy shows rare HER2 missense mutations usually do not spread breasts cancer on their ownSausages With ...
The FDA approved South San Francisco, Calif.-based Talon Therapeutics Marqibo (vincristine sulfate liposome), an injectable drug for Philadelphia chromosome-negative acute lymphoblasic leukemia, or Ph-negative ALL. The drug, which consists of the widely used anti-cancer drug vincristine encased within a liposome - a drug delivery system made of a material similar to cell membranes - is approved for patients whose leukemia has returned twice or more or has progressed after two or more regimens of therapy.. According to the National Cancer Institute, part of the National Institutes of Health, more than 6,000 people will be diagnosed with ALL this year, and 1,440 will die from it. The disease is a rapidly progressing form of blood and bone marrow cancer more common in children than adults.. ...
Polysulfated glycosaminoglycan (PSGAG), sold under the brand name Adequan, is an injectable drug for dogs and horses that is used to improve the lameness, lowered range of motion, and pain that comes with arthritis, and is one of the most widely prescribed joint supplements for horses. It is made of repeat disaccharide units of hexosamine and hexuronic acid, and is similar to glycosaminoglycans already present in the cartilage, and thus easily taken up. In vitro studies have shown it to work by inhibiting the enzymes that cause the cartilage and bone to degrade, as well as inhibiting inflammation and stimulating the synthesis of replacement cartilage. While it can cause an increased risk of bleeding, its relatively safe and has a high LD50. While it is widely prescribed, some studies still show conflicting results in terms of efficacy, causing some to claim that PSGAG is not solely responsible for the significant mitigation of arthritis seen in success cases. PSGAG is mostly used in dogs and ...
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ENGLISH ABSTRACT: Central dogma suggests that mutations in target genes is the primary cause of resistance to first and second-line anti-TB drugs in Mycobacterium tuberculosis. However, it was previously reported that approximately 5% of Rifampicin mono-resistant clinical M. tuberculosis did not harbor mutations in the rpoB gene. The present study hypothesized that active efflux plays a contributory role in the level of intrinsic resistance to different anti-TB drugs (Isoniazid, Ethionamide, Pyrazinamide, Ethambutol, Ofloxacin, Moxifloxacin, Ciprofloxacin, Streptomycin, Amikacin and Capreomycin in RIF mono-resistant clinical M. tuberculosis isolates with a rpoB531 (Ser-Leu) mutation. This study aimed to define the role of Efflux pump inhibitors (verapamil, carbonylcyanide m-chlorophenylhydrazone and reserpine) in enhancing the susceptibility to different anti-TB drugs in the RIF mono-resistant clinical isolates. The isolates were characterized by determining the level of intrinsic resistance to ...
UNITED BIOTECH (P) LTD is Manufacturer and exporter of Antituberculosis Drugs,Atorvastatin Tablets,Ganciclovir Capsules,Heparin Injection based in Delhi,In
SILVER SPRING, Md. - The Food and Drug Administration has approved a new drug for treating a rare type of leukemia, the agency said Thursday.. The FDA approved South San Francisco, Calif.-based Talon Therapeutics Marqibo (vincristine sulfate liposome), an injectable drug for Philadelphia chromosome-negative acute lymphoblasic leukemia, or Ph-negative ALL. The drug, which consists of the widely used anti-cancer drug vincristine encased within a liposome - a drug delivery system made of a material similar to cell membranes - is approved for patients whose leukemia has returned twice or more or has progressed after two or more regimens of therapy.. According to the National Cancer Institute, part of the National Institutes of Health, more than 6,000 people will be diagnosed with ALL this year, and 1,440 will die from it. The disease is a rapidly progressing form of blood and bone marrow cancer more common in children than adults.. ...
Sponsored Links The study also found that Byetta (exenatide) may raise the risk of thyroid cancer. Although the links arent conclusive, they merit further investigation, the researchers noted. We have raised concern that there may be a link, but we havent confirmed it, said lead researcher Dr. Peter Butler, director of the Larry L. Hillblom Islet Research Center at the University of California, Los Angeles. We need to do more work to figure out whether this is real or not. Both drugs help control blood sugar levels by encouraging production of a hormone called glucagon-like peptide 1 (GLP-1). Januvia (sitagliptin) and Byetta, an injectable drug, are a new way of treating type 2 diabetes, and they potentially have advantages over older medications, Butler said. But, because these drugs are new, theyre the ones we know least about, he said. When new drugs come out, the long-term side effects of these drugs are not well understood. For the study, recently published in the journal ...
HealthDay Reporter. THURSDAY, Sept. 28, 2017 (HealthDay News) -- Expensive new medicines offer hope to patients with uncontrolled "bad" cholesterol, but the high cost keeps many patients from getting them, a new study says.. The injectable drugs -- approved for use in the United States in 2015 -- are known as PCSK9 inhibitors. They include Praluent (alirocumab) and Repatha (evolocumab).. But, researchers found, of tens of thousands of patients prescribed the drugs, nearly half were denied insurance coverage. And high copays seemed to prevent many others from filling their prescriptions.. "We were surprised by how little clinical factors -- like how high your cholesterol was -- mattered to whether or not you got approved," said study lead author Dr. Ann Marie Navar.. "We hope that this analysis prompts a bigger assessment of how limited patient access is to new therapies," added Navar, an assistant professor of cardiology at Duke Clinical Research Institute in Durham, N.C. Elevated LDL ...
September 10, 2014 (Boston Buisness Journal) - Gail Glazier knew she would be coming to Mass. Eye and Ear before her first appointment. Her father and aunt both had macular degeneration, which is a hereditary disease. When she came to Mass. Eye and Ear in 2006, she was surprised to see the breakthrough that our researchers discovered. Six researchers from Mass. Eye and Ear, along with one researcher from the University of California, San Diego, created an injectable drug that stops the fluid from leaking into the retina. The seven researchers involved in this discovery have recently earned the 2014 Champalimaud Award, which is known as visions Nobel Prize. According to Dr. Joan Miller of Mass. Eye and Ear, "What (the Champalimaud Vision Award jury) liked is it went from the basic science…identifying the molecule to the translation into models and patients and now treatments given to about 1 million patients around the world." The researchers will get 1 million Euros ($1.3 million), split ...
In hospitals, the nursing staff is often confronted with the problem of the preparation and administration of drugs for their pediatric patients because of the lack of indication, pediatric dosage, and appropriate galenic form. The goal of this study was to give an overview of the nurses preparation habits in pediatric units and highlight their daily problems. This single-center prospective study was conducted through an observation of the nursing staff during the drug preparation process in medicine, surgery and intensive care units. We included 91 patients (55 boys and 36 girls), with an average age of 6.3 years (youngest child, 10 days old; oldest child, 18 years old). We observed a mean 2.16 drug preparations per patient [1-5]. We collected 197 observation reports regarding 66 injectable drugs and 131 oral drugs (71 liquid forms and 60 solid forms). The majority of these reports concerned central nervous system drugs (63/197), metabolism and digestive system drugs (50/197), and ...
Biosimilar and follow-on protein products. Also, how will 11 injectable drugs - including Lantus, Humalog, NovoLog, Humira and Enbrel - perform from 2014? You will find the potential revenues for these drugs to 2024.. Market Size and Growth Prospects. What does the future hold? Overall revenues from pre-filled syringes will rise from 2014 to 2024, our report forecasts. Improved drug delivery and new formulations will be vital to pharmaceutical companies, increasing demand for innovative medical injection devices.. In 2012, 2.96 billion of those syringe units sold. Pre-filled syringes form one of the fastest growing markets in healthcare.. Safety, stability, convenience and cost-effectiveness benefit unit sales and revenues. Our analyses predict strong revenue growth to 2024 for those medical devices and their applications in human therapy.. Discover profiles for leading companies. Our work profiles leading companies, assessing their technologies and products. You will see activities and outlooks ...
AMAG Pharmaceuticals Inc. (AMAG) recently announced a label update for its lead drug Feraheme. Feraheme is an injectable drug for intravenous use as an iron replacement therapy for the treatment of iron deficiency anemia (IDA) in adult patients suffering from chronic kidney disease (CKD).. The label was updated following approval by the US Food and Drug Administration (FDA) of the companys Label Supplement submission which included additional post-marketing safety data.. AMAG modified its Warnings and Precautions section to revise the language used to describe the hypersensitivity reactions. The revised label mentions that fatal and life-threatening serious hypersensitivity reactions, including anaphylactic-type reactions, have been reported in patients who have received Feraheme.. The Contraindications section was also modified to remove language relating to evidence of iron overload and anemia not caused by iron deficiency. Finally the observation time of the patients for signs and symptoms ...
SAN DIEGO, Sept. 30, 2015 (GLOBE NEWSWIRE) - Neothetics, Inc. (NASDAQ:NEOT), a clinical-stage specialty pharmaceutical company developing therapeutics for the aesthetic market, today announced the initiation of the safety study, LIPO-202-CL-21, of LIPO-202, the first non-invasive injectable drug candidate for reduction of central abdominal bulging due to subcutaneous fat in non-obese subjects. This is a supplemental safety study that Neothetics expects to submit to the U.S. Food and Drug Administration (FDA) as part of the companys New Drug Application (NDA) package for LIPO-202, which the company anticipates filing in the second half of 2016.. "This study highlights the comprehensiveness of our clinical development program that supports our New Drug Application for LIPO-202, which is on track to be filed in the second half of 2016," said Lincoln Krochmal, M.D., Chief Medical Officer for Neothetics. "While we are seeking approval of LIPO-202 for use in non-obese subjects, we recognize the ...
Dermal filler is an injectable drug used to diminish facial lines and restore volume and fullness in the face. It is used to plump thin lips, soften facial creases and wrinkles, enhance shallow contours, and improve the appearance of recessed scars. One of the aspects of modern life, which is considered as essential by men as well as women is appearance. The urge to look as good as they feel has led to the notable growth in the cosmetology industry ...
While treatment as prevention (TasP) involves prescribing antitretroviral treatment (ART) to HIV-positive individuals to lessen the risk of them passing the HIV infection onto others, PrEP is a prevention strategy that involves providing ART to HIV-negative individuals to protect them from contracting HIV. While TasP may be recommended along with condom use to a monogamous couple in which one individual is HIV-positive and the other HIV-negative, PrEP may be recommended for individuals at high risk for HIV infection, such as men who have had anal sex without a condom, individuals with multiple sex partners or a history of sexually transmitted infections (STIs), sex workers and injectable drug users. By consistently taking ART before any possible HIV exposure occurs, an individual can reduce the risk of HIV infection by up to 92 percent, according to the Centers for Disease Control and Prevention (CDC).. According to CDC recommendations, providers should assess a patients HIV risk factors and ...
Definition of cross-resistance in the Legal Dictionary - by Free online English dictionary and encyclopedia. What is cross-resistance? Meaning of cross-resistance as a legal term. What does cross-resistance mean in law?
Discussions about SOAP::Lite, XMLRPC::Lite and UDDI::Lite for Perl (www.soaplite.com). Easy access to information about released versions, features and on-going development.

capreomycin - WellSpan Health Librarycapreomycin - WellSpan Health Library

Capreomycin is usually given after other tuberculosis medications have been tried without success. Capreomycin may also be used ... Capreomycin is used in combination with other medicines to treat Mycobacterium tuberculosis. ... Capreomycin is an antibiotic that fights bacteria in the body. ... What is capreomycin?. Capreomycin is an antibiotic that fights ... What other drugs will affect capreomycin?. Capreomycin can harm your kidneys or damage the nerve that controls your hearing. ...
more infohttp://www.wellspan.org/health-library/Document.aspx?id=d01103a1

capreomycin Injection - patient information, description, dosage and directions.capreomycin Injection - patient information, description, dosage and directions.

Description of the drug capreomycin Injection. - patient information, description, dosage and directions. What is capreomycin ... capreomycin (Injection route). kap-ree-oh-MYE-sin. Injection routePowder for Solution. The use of capreomycin in patients with ... Capreomycin is available only with your doctors prescription.. Before Using capreomycin. In deciding to use a medicine, the ... Proper Use of capreomycin. To help clear up your infection completely, it is very important that you keep taking capreomycin ...
more infohttp://drugster.info/drug/medicament/4063/

CapreomycinCapreomycin

... is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety ... Capreomycin. Capreomycin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a ... Capreomycin is a generic medicine. Branded medicines containing capreomycin are not currently available. ... Capreomycin is not absorbed from the gut and so cant be given by mouth. The treatment is therefore only given by injection. ...
more infohttps://www.netdoctor.co.uk/medicines/infection/a6367/capreomycin/

Amikacin/capreomycin | SpringerLinkAmikacin/capreomycin | SpringerLink

Adverse effects and choice between the Injectable agents amikacin and capreomycin in Multidrug-resistant tuberculosis. ...
more infohttps://link.springer.com/article/10.1007/s40278-017-37126-0

capreomycin | Cignacapreomycin | Cigna

Capreomycin is usually given after other tuberculosis medications have been tried without success. Capreomycin may also be used ... Capreomycin is used in combination with other medicines to treat Mycobacterium tuberculosis. ... Capreomycin is an antibiotic that fights bacteria in the body. ... What is capreomycin?. Capreomycin is an antibiotic that fights ... What other drugs will affect capreomycin?. Capreomycin can harm your kidneys or damage the nerve that controls your hearing. ...
more infohttps://www.cigna.com/individuals-families/health-wellness/hw/medications/capreomycin-d01103a1

Capreomycin Dosage Guide with Precautions - Drugs.comCapreomycin Dosage Guide with Precautions - Drugs.com

Detailed Capreomycin dosage information for adults and children. Includes dosages for Tuberculosis - Active; plus renal, liver ... Due to rapid development of resistance, capreomycin should not be used alone for the treatment of tuberculosis. It should be ... Capreomycin is removed by hemodialysis. The dose should be administered after a dialysis session. ... Large intravenous doses of capreomycin may cause partial neuromuscular blockade.. Since hypokalemia, hypomagnesemia and ...
more infohttps://www.drugs.com/dosage/capreomycin.html

Capreomycin Injection Advanced Patient Information - Drugs.comCapreomycin Injection Advanced Patient Information - Drugs.com

Detailed drug Information for capreomycin Injection. Includes common brand names, drug descriptions, warnings, side effects and ... Precautions While Using capreomycin. Your doctor will check your progress closely while you are receiving capreomycin. This ... Capreomycin (Injection). kap-ree-oh-MYE-sin. Injection route(Powder for Solution) Use capreomycin in patients with renal ... Proper Use of capreomycin. A nurse or other trained health professional will give you capreomycin in a hospital or clinic ...
more infohttps://www.drugs.com/cons/capreomycin-injection.html

Capreomycin Sulfate, Meets USPCapreomycin Sulfate, Meets USP

Capreomycin sulfate, USP, 1 g. CAS Number: 1405-37-4 Molecular Formula: C25H46N14O11S Molecular Weight: 750.79 ... Capreomycin is a cyclic peptide antibiotic that is often grouped with aminoglycosides. It binds across the ribosomal interface ... Capreomycin is used to study bacterial ribosomal subunit interactions and translocation processes during protein synthesis. It ...
more infohttps://www.mpbio.com/0218069991-capreomycin-sulfate-meets-usp

Capreomycin - WikipediaCapreomycin - Wikipedia

Capreomycin is commonly grouped with the aminoglycoside family of medications. How it works is unclear. Capreomycin was ... Capreomycin is an antibiotic which is given in combination with other antibiotics for the treatment of tuberculosis. ... "TB Online - Capreomycin". Archived from the original on 13 January 2015. Retrieved 14 September 2014. "WHO Model List of ... In 1979, capreomycin was used in the area of antituberculosis by inhibiting the growth of mycobacterium tuberculosis. " ...
more infohttps://en.wikipedia.org/wiki/Capreomycin

Macleods capreomycin injection prequalified | WHO - Prequalification of Medicines ProgrammeMacleods' capreomycin injection prequalified | WHO - Prequalification of Medicines Programme

Macleods capreomycin injection prequalified. 09 May 2016 WHO Prequalification Team - Medicines (PQT) added the below new ... TB211: Capreomycin (as sulfate) - 1g - Powder for injection - Macleods Pharmaceuticals Limited - INDIA ...
more infohttps://extranet.who.int/prequal/news/macleods-capreomycin-injection-prequalified

capreomycin - oicapreomycin - oi

Unexpected N-acetylation of capreomycin by mycobacterial Eis enzymes Elucidation of Mycobacterium abscessus aminoglycoside and ... capreomycin resistance by targeted deletion of three putative resistance genes Comparison of clinical isolates and in vitro ... selected mutants reveals that tlyA is not a sensitive genetic marker for capreomycin resistance in Mycobacterium tuberculosis ...
more infohttp://oxfordindex.oup.com/view/10.1093/oi/authority.20110803095547470

Buy Online CAS Number 1405-37-4 - BP - Capreomycin sulfate | LGC StandardsBuy Online CAS Number 1405-37-4 - BP - Capreomycin sulfate | LGC Standards

Purchase online Capreomycin sulfate BP 059 - CAS Number 1405-37-4. High Quality CRMs, Reference Materials, Proficiency Testing ...
more infohttps://www.lgcstandards.com/GB/en/Capreomycin-sulfate/p/BP%20059

Genome-wide exploration of the drug action of capreomycin on Mycobacterium tuberculosis using Affymetrix oligonucleotide...Genome-wide exploration of the drug action of capreomycin on Mycobacterium tuberculosis using Affymetrix oligonucleotide...

Capreomycin is an important drug used for TB with multi-drug resistance. A recent study also indicates that this drug possesses ... The results indicate that capreomycin primarily acts on the information pathways but it also significantly affects cell wall, ... Here we conduct the first microarray-based study on capreomycin using the high-resolution Affymetrix oligonucleotide GeneChip ... Genome-wide exploration of the drug action of capreomycin on Mycobacterium tuberculosis using Affymetrix oligonucleotide ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/16822547?dopt=Abstract

The Differential Gene Expression Pattern of Mycobacterium tuberculosis in Response to Capreomycin and PA-824 versus First-Line...The Differential Gene Expression Pattern of Mycobacterium tuberculosis in Response to Capreomycin and PA-824 versus First-Line...

Capreomycin is an old antibiotic for treatment of pulmonary tuberculosis [7] with recently increasing interest. Capreomycin is ... In our prior study on capreomycin, the upregulation of isocitrate lyase (ICL) suggests that capreomycin can affect the ... only capreomycin is active against nonreplicating M. tuberculosis bacilli in an in vitro model of persistence [9]. Capreomycin ... capreomycin and PA-824. In the present study, we identified genes differentially expressed in response to capreomycin and PA- ...
more infohttps://www.hindawi.com/journals/ijmicro/2009/879621/

Capastat Sulfate (Capreomycin) Injection: Uses, Dosage & Side EffectsCapastat Sulfate (Capreomycin) Injection: Uses, Dosage & Side Effects

Capreomycin is used to treat tuberculosis (TB). It is given with other medicines for TB. To help clear up your tuberculosis (TB ... After this time, 1 gram of capreomycin is injected into the muscle 2 or 3 times a week. This medicine must be given with other ... Capreomycin is used to treat tuberculosis (TB). It is given with other medicines for TB. ... There is no specific information comparing use of capreomycin in the elderly with use in other age groups. ...
more infohttps://www.findatopdoc.com/Medical-Library/Drugs-and-Supplements/Capastat-Sulfate

WHO | Kanamycin & Capreomycin - EML and EMLcWHO | Kanamycin & Capreomycin - EML and EMLc

Application for Kanamycin & Capreomycin. pdf, 121kb WHO Department comments:. Public comments:. * Treatment Action Group. pdf, ... Kanamycin & Capreomycin - EML and EMLc. 22nd Expert Committee on the Selection and Use of Essential Medicines ...
more infohttp://origin.who.int/entity/selection_medicines/committees/expert/22/applications/Kanamycin-Capreomycin-eml/en/

Molecular characterization of amikacin, kanamycin and capreomycin resistance in M/XDR-TB strains isolated in Thailand | BMC...Molecular characterization of amikacin, kanamycin and capreomycin resistance in M/XDR-TB strains isolated in Thailand | BMC...

Capreomycin resistance was determined in 28 of 29 KM-resistant strains. Analysis of tlyA revealed that the A33G mutation was ... and capreomycin (CAP) are well understood. This study aims to validate the mechanisms associated with AK, KM, and CAP ... Capreomycin resistance was determined in 28 of 29 KM-resistant strains. Analysis of tlyA revealed that the A33G mutation was ... Molecular analysis of genes associated with amikacin, kanamycin, and capreomycin resistance. The 16S rRNA genes (rrs) of all 29 ...
more infohttps://bmcmicrobiol.biomedcentral.com/articles/10.1186/1471-2180-14-165

Disparities in capreomycin resistance levels associated with the rrs A1401G mutation in clinical isolates of Mycobacterium...Disparities in capreomycin resistance levels associated with the rrs A1401G mutation in clinical isolates of Mycobacterium...

Disparities in capreomycin resistance levels associated with the rrs A1401G mutation in clinical isolates of Mycobacterium ... Disparities in Capreomycin Resistance Levels Associated with the rrs A1401G Mutation in Clinical Isolates of Mycobacterium ... capreomycin (CAP), kanamycin, and amikacin. However, discordance is often observed between the rrs A1401G mutation and CAP ...
more infohttps://phgkb.cdc.gov/PHGKB/phgHome.action?action=forward&dbsource=cdcpub&id=2867

Treatment of Tuberculosis and Tuberculosis Infection in Adults and ChildrenTreatment of Tuberculosis and Tuberculosis Infection in Adults and Children

Capreomycin. Capreomycin is an injectable antituberculosis agent. It is available in 1-g vials, and the daily dosage is 15 to ... When there is similar susceptibility to capreomycin and amikacin, capreomycin should be used if the patient is 60 yr of age or ... Capreomycin. Kanamycin. Thiacetazone. POTENTIALLY EFFECTIVE DRUGS THAT HAVE NOT BEEN WIDELY USED IN THE THERAPY OF TUBERCULOSIS ... Capreomycin is toxic to the eighth cranial nerve, causing high frequency hearing loss in 3.2 to 9.4% of patients before ...
more infohttps://wonder.cdc.gov/wonder/prevguid/p0000413/p0000413.asp

Course Content - #54552: Tuberculosis: An Update - NetCECourse Content - #54552: Tuberculosis: An Update - NetCE

A tuberculostatic, the usual adult dosage of capreomycin is 15 mg/kg/day intramuscularly; in children the dosage is 15-20 mg/kg ... Capreomycin. 15 mg/kg IM/IV. Auditory and renal toxicity, vestibular toxicity, hypokalemia. ... aInjectable agents include aminoglycosides (such as streptomycin, kanamycin, and amikacin) or capreomycin. ...
more infohttps://www.netce.com/coursecontent.php?courseid=1385

Course Content - #94552: Tuberculosis: An Update - NetCECourse Content - #94552: Tuberculosis: An Update - NetCE

A tuberculostatic, the usual adult dosage of capreomycin is 15 mg/kg/day intramuscularly; in children the dosage is 15-20 mg/kg ... Capreomycin. 15 mg/kg IM/IV. Auditory and renal toxicity, vestibular toxicity, hypokalemia. ... aInjectable agents include aminoglycosides (such as streptomycin, kanamycin, and amikacin) or capreomycin. ...
more infohttp://www.netce.com/coursecontent.php?courseid=1384

Clomipramine Impurity F- CAS Number 32943-25-2Clomipramine Impurity F- CAS Number 32943-25-2

Capreomycin sulfate. 50 mg. BP 059. Add to basket Captopril Assay Standard. 100 mg. BP 538. Add to basket ...
more infohttps://www.lgcstandards.com/DE/en/Clomipramine-Impurity-F/p/BP%20983

A jab or a pill, that is the tuberculosis question | The Indian ExpressA jab or a pill, that is the tuberculosis question | The Indian Express

It uses injectables kanamycin, capreomycin and amikacin. Bedaquiline was rolled out in 2016 in a phase-wise control trial. ... It uses injectables kanamycin, capreomycin and amikacin. Bedaquiline was rolled out in 2016 in a phase-wise control trial. ... It uses injectables kanamycin, capreomycin and amikacin. Bedaquiline was rolled out in 2016 in a phase-wise control trial. Only ... The three commonly-used injectables, kanamycin, capreomycin and amikacin, have severe side effects, including kidney ailments, ...
more infohttps://indianexpress.com/article/explained/tuberculosis-in-india-world-health-organisation-drugs-bedaquiline-5233253/

Palabras clavePalabras clave

Global Specifications: The Example of Capreomycin - Pharmacopoeial Standards. (WHO Drug Information Vol. 28, No. 4, 2014) Temas ...
more infohttp://apps.who.int/medicinedocs/es/cl/CL6.1.1.1.1.2713/clmd,50.html
  • However, elderly patients are more likely to have kidney and hearing problems, which may require caution and an adjustment in the dose for patients receiving capreomycin. (drugs.com)
  • Yet, the knowledge in this area is fundamentally limited and only a few drugs, notably capreomycin and PA-824, have been shown to be active against non-replicating persistent TB bacilli. (hindawi.com)
  • In this study, we performed a new bioinformatics analysis on microarray-based gene expression data obtained from the public domain to explore genes that were differentially induced by drugs between the group of capreomycin and PA-824 and the group of mainly the first-line TB drugs. (hindawi.com)
  • Using capreomycin with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. (drugster.info)
  • Use capreomycin in patients with renal insufficiency or preexisting auditory impairment with great caution, and the risk of additional auditory impairment or renal injury should be weighed against the benefits to be derived from therapy. (drugs.com)
  • Since other parenteral antituberculosis agents (streptomycin, viomycin) also have similar and sometimes irreversible toxic effects, particularly on cranial nerve VIII and renal function, simultaneous administration of these agents with capreomycin is not recommended. (drugster.info)
  • Capreomycin can harm your kidneys or damage the nerve that controls your hearing. (cigna.com)
  • This study not only transcriptionally validates the specific molecular target, 16S rRNA, but also discovers potential new targets of capreomycin, including genes operating at the DNA level, such as Rv0054 (ssb) and Rv3715c (recR), as well as genes involved in cell division like Rv3260c (whiB2). (nih.gov)
  • Our study has identified 42 genes specifically induced by capreomycin and PA-824. (hindawi.com)
  • Global Specifications: The Example of Capreomycin - Pharmacopoeial Standards. (who.int)
  • Capreomycin is used to study bacterial ribosomal subunit interactions and translocation processes during protein synthesis. (mpbio.com)
  • Here we conduct the first microarray-based study on capreomycin using the high-resolution Affymetrix oligonucleotide GeneChip system. (nih.gov)
  • Capreomycin works by affecting the bacteria's production of certain proteins that are necessary for their survival. (netdoctor.co.uk)
  • Studies on capreomycin have been done only in adult patients, and there is no specific information comparing use of capreomycin in children with use in other age groups. (drugster.info)
  • Capreomycin may also be used for purposes not listed in this medication guide. (cigna.com)
  • Thus, there is an urgent need for investigating the full-spectrum action of capreomycin. (nih.gov)
  • Capreomycin is to be given only by or under the direct supervision of your doctor. (drugs.com)