The property of blood capillary ENDOTHELIUM that allows for the selective exchange of substances between the blood and surrounding tissues and through membranous barriers such as the BLOOD-AIR BARRIER; BLOOD-AQUEOUS BARRIER; BLOOD-BRAIN BARRIER; BLOOD-NERVE BARRIER; BLOOD-RETINAL BARRIER; and BLOOD-TESTIS BARRIER. Small lipid-soluble molecules such as carbon dioxide and oxygen move freely by diffusion. Water and water-soluble molecules cannot pass through the endothelial walls and are dependent on microscopic pores. These pores show narrow areas (TIGHT JUNCTIONS) which may limit large molecule movement.
The minute vessels that connect the arterioles and venules.
One of the HISTAMINE H1 ANTAGONISTS with little sedative action. It is used in treatment of hay fever, rhinitis, allergic dermatoses, and pruritus.
A condition characterized by recurring episodes of fluid leaking from capillaries into extra-vascular compartments causing hematocrit to rise precipitously. If not treated, generalized vascular leak can lead to generalized EDEMA; SHOCK; cardiovascular collapse; and MULTIPLE ORGAN FAILURE.
Property of membranes and other structures to permit passage of light, heat, gases, liquids, metabolites, and mineral ions.
Normal human serum albumin mildly iodinated with radioactive iodine (131-I) which has a half-life of 8 days, and emits beta and gamma rays. It is used as a diagnostic aid in blood volume determination. (from Merck Index, 11th ed)
The widespread involvement of the skin by a scaly, erythematous dermatitis occurring either as a secondary or reactive process to an underlying cutaneous disorder (e.g., atopic dermatitis, psoriasis, etc.), or as a primary or idiopathic disease. It is often associated with the loss of hair and nails, hyperkeratosis of the palms and soles, and pruritus. (From Dorland, 27th ed)
One of the PENICILLINS which is resistant to PENICILLINASE.
A glucocorticoid with the general properties of corticosteroids. It has been used by mouth in the treatment of all conditions in which corticosteroid therapy is indicated except adrenal-deficiency states for which its lack of sodium-retaining properties makes it less suitable than HYDROCORTISONE with supplementary FLUDROCORTISONE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p737)
Excessive accumulation of extravascular fluid in the lung, an indication of a serious underlying disease or disorder. Pulmonary edema prevents efficient PULMONARY GAS EXCHANGE in the PULMONARY ALVEOLI, and can be life-threatening.
Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.
A major protein in the BLOOD. It is important in maintaining the colloidal osmotic pressure and transporting large organic molecules.
A quality of cell membranes which permits the passage of solvents and solutes into and out of cells.
A complication of OVULATION INDUCTION in infertility treatment. It is graded by the severity of symptoms which include OVARY enlargement, multiple OVARIAN FOLLICLES; OVARIAN CYSTS; ASCITES; and generalized EDEMA. The full-blown syndrome may lead to RENAL FAILURE, respiratory distress, and even DEATH. Increased capillary permeability is caused by the vasoactive substances, such as VASCULAR ENDOTHELIAL GROWTH FACTORS, secreted by the overly-stimulated OVARIES.
Volume of PLASMA in the circulation. It is usually measured by INDICATOR DILUTION TECHNIQUES.
A highly-sensitive (in the picomolar range, which is 10,000-fold more sensitive than conventional electrophoresis) and efficient technique that allows separation of PROTEINS; NUCLEIC ACIDS; and CARBOHYDRATES. (Segen, Dictionary of Modern Medicine, 1992)
A phthalic indicator dye that appears yellow-green in normal tear film and bright green in a more alkaline medium such as the aqueous humor.
An amine derived by enzymatic decarboxylation of HISTIDINE. It is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and also a centrally acting neurotransmitter.
Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.
Volume of circulating BLOOD. It is the sum of the PLASMA VOLUME and ERYTHROCYTE VOLUME.
Treatment process involving the injection of fluid into an organ or tissue.
Single pavement layer of cells which line the luminal surface of the entire vascular system and regulate the transport of macromolecules and blood components.
The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.
The movement of materials (including biochemical substances and drugs) through a biological system at the cellular level. The transport can be across cell membranes and epithelial layers. It also can occur within intracellular compartments and extracellular compartments.
A phenomenon in which the surface of a liquid where it contacts a solid is elevated or depressed, because of the relative attraction of the molecules of the liquid for each other and for those of the solid. (from McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.
Elements of limited time intervals, contributing to particular results or situations.
Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.
The vascular resistance to the flow of BLOOD through the CAPILLARIES portions of the peripheral vascular bed.
A dull red, firm, dome-shaped hemangioma, sharply demarcated from surrounding skin, usually located on the head and neck, which grows rapidly and generally undergoes regression and involution without scarring. It is caused by proliferation of immature capillary vessels in active stroma, and is usually present at birth or occurs within the first two or three months of life. (Dorland, 27th ed)
A separation technique which combines LIQUID CHROMATOGRAPHY and CAPILLARY ELECTROPHORESIS.
Specialized non-fenestrated tightly-joined ENDOTHELIAL CELLS with TIGHT JUNCTIONS that form a transport barrier for certain substances between the cerebral capillaries and the BRAIN tissue.
Cell-cell junctions that seal adjacent epithelial cells together, preventing the passage of most dissolved molecules from one side of the epithelial sheet to the other. (Alberts et al., Molecular Biology of the Cell, 2nd ed, p22)

Potent mast cell degranulation and vascular permeability triggered by urocortin through activation of corticotropin-releasing hormone receptors. (1/3442)

Urocortin (Ucn) is related to corticotropin-releasing hormone (CRH), and both are released in the brain under stress where they stimulate CRH 1 and 2 receptors (CRHR). Outside the brain, they may have proinflammatory actions through activation of mast cells, which are located perivascularly close to nerve endings and degranulate in response to acute psychological stress. Here, we report that a concentration of intradermal Ucn as low as 10 nM induced dose-dependent rat skin mast cell degranulation and increased vascular permeability. This effect appeared to be equipotent to that of calcitonin gene-related peptide and neurotensin. Ucn-induced skin vasodilation was inhibited by pretreatment with the mast cell stabilizer disodium cromoglycate (cromolyn) and was absent in the mast cell-deficient W/Wv mice. The selective nonpeptide CRH receptor 1 antagonist, antalarmin and the nonselective peptide antagonist astressin both reduced vascular permeability triggered by Ucn but not that by Substance P or histamine. In contrast, the peptide antagonist alpha-helical CRH-(9-41) reduced the effect of all three. The vasodilatory effect of Ucn was largely inhibited by pretreatment with H1 receptor antagonists, suggesting that histamine is the major mediator involved in vitro. Neuropeptide depletion of sensory neurons, treatment with the ganglionic blocker hexamethonium, or in situ skin infiltration with the local anesthetic lidocaine did not affect Ucn-induced vascular permeability, indicating that its in situ effect was not mediated through the peripheral nervous system. These results indicate that Ucn is one of the most potent triggers of rat mast cell degranulation and skin vascular permeability. This effect of Ucn may explain stress-induced disorders, such as atopic dermatitis or psoriasis, and may lead to new forms of treatment.  (+info)

Reduction of sodium deoxycholic acid-induced scratching behaviour by bradykinin B2 receptor antagonists. (2/3442)

1. Subcutaneous injection of sodium deoxycholic acid into the anterior of the back of male ddY mice elicited dose-dependent scratching of the injected site with the forepaws and hindpaws. 2. Up to 100 microg of sodium deoxycholic acid induced no significant increase in vascular permeability at the injection site as assessed by a dye leakage method. 3. Bradykinin (BK) B2 receptor antagonists, FR173657 and Hoe140, significantly decreased the frequency of scratching induced by sodium deoxycholic acid. 4. Treatment with aprotinin to inhibit tissue kallikrein reduced the scratching behaviour induced by sodium deoxycholic acid, whereas treatment with soybean trypsin inhibitor to inhibit plasma kallikrein did not. 5. Although injection of kininase II inhibitor, lisinopril together with sodium deoxycholic acid did not alter the scratching behaviour, phosphoramidon, a neutral endopeptidase inhibitor, significantly increased the frequency of scratching. 6. Homogenates of the skin excised from the backs of mice were subjected to gel-filtration column chromatography followed by an assay of kinin release by trypsin from each fraction separated. Less kinin release from the fractions containing kininogen of low molecular weight was observed in the skin injected with sodium deoxycholic acid than in normal skin. 7. The frequency of scratching after the injection of sodium deoxycholic acid in plasma kininogen-deficient Brown Norway Katholiek rats was significantly lower than that in normal rats of the same strain, Brown Norway Kitasato rats. 8. These results indicate that BK released from low-molecular-weight kininogen by tissue kallikrein, but not from high-molecular-weight kininogen by plasma kallikrein, may be involved in the scratching behaviour induced by the injection of sodium deoxycholic acid in the rodent.  (+info)

Role for nitric oxide in the hyperpermeability and hemodynamic changes induced by intravenous VEGF. (3/3442)

PURPOSE: To explore the effects of brief intravenous (IV) infusion of vascular endothelial growth factor (VEGF) on vascular albumin permeability, blood flow, and vascular conductance (blood flow normalized to arterial blood pressure) in ocular tissues and brain and to assess the role of nitric oxide in mediating these changes. METHODS: A quantitative, double-tracer, radiolabeled albumin permeation method was combined with radiolabeled microspheres for assessment of changes in vascular permeability and blood flow, respectively, induced in ocular tissues by IV infusion of recombinant human VEGF165 for 20 minutes (80-450 picomoles/kg body weight). An inhibitor of nitric oxide synthase (NOS), NG-monomethyl-L-arginine (L-NMMA; 50 micromoles/kg body weight infused simultaneously with VEGF), was used to explore the role of nitric oxide in mediating the vascular changes induced by VEGF. RESULTS: Infusion of VEGF165 in thiopental-anesthetized rats dose-dependently increased 125I albumin permeation in the retina, anterior uvea, and choroid/sclera and in brain, aorta, lung, kidney, small intestine, and peripheral nerve. Mean arterial blood pressure, cardiac output, and stroke volume were decreased only at the highest dose of VEGF, whereas heart rate remained unchanged. Blood flow was increased in the anterior uvea, and vascular conductance was increased in retina, anterior uvea, choroid/sclera, and brain at the highest dose of VEGF. The NOS inhibitor, L-NMMA, blocked VEGF-induced vascular hyperpermeability in all ocular and nonocular tissues, prevented the increase in vascular conductance in all ocular tissues, and blocked the decrease in mean arterial blood pressure, cardiac output, and stroke volume. Infusion of L-NMMA alone decreased vascular conductance in choroid/sclera and kidney, slightly increased mean arterial blood pressure, and in general, did not affect 125I-albumin permeation. (L-NMMA slightly decreased albumin permeation in the retina and increased it in the brain.) CONCLUSIONS: Intravenous infusion of VEGF can acutely impair endothelial cell barrier functional integrity and relax resistance arterioles in ocular tissues and brain through a mechanism involving activation of NOS.  (+info)

Strain-dependent induction of allergic sensitization caused by peanut allergen DNA immunization in mice. (4/3442)

To investigate the potential application of allergen gene immunization in the modulation of food allergy, C3H/HeSn (C3H) mice received i.m. injections of pAra h2 plasmid DNA encoding one of the major peanut allergens, Ara h2. Three weeks following pDNA immunization, serum Ara h2-specific IgG2a, IgG1, but not IgE, were increased significantly in a dose-dependent manner. IgG1 was 30-fold higher in multiply compared with singly immunized mice. Ara h2 or peanut protein injection of immunized mice induced anaphylactic reactions, which were more severe in multiply immunized mice. Heat-inactivated immune serum induced passive cutaneous anaphylaxis, suggesting that anaphylaxis in C3H mice was mediated by IgG1. IgG1 responses were also induced by intradermal injection of pAra h2, and by i.m. injection of pOMC, the plasmid DNA encoding the major egg allergen protein, ovomucoid. To elucidate whether the pDNA immunization-induced anaphylaxis was a strain-dependent phenomenon, AKR/J and BALB/c mice also received multiple i.m. pAra h2 immunizations. Injection of peanut protein into these strains at weeks 3 or 5 following immunization did not induce reactions. Although IgG2a was increased significantly from week 2 in AKR/J mice and from week 4 in BALB/c mice and remained elevated for at least 6 wk, no IgG1 or IgE was detected. These results indicate that the type of immune responses to pDNA immunization in mice is strain dependent. Consequently, models for studying human allergen gene immunization require careful selection of suitable strains. In addition, this suggests that similar interindividual variation is likely in humans.  (+info)

Antipsoriatic, anti-inflammatory, and analgesic effects of an extract of red propolis. (5/3442)

AIM: To study the antipsoriatic, anti-inflammatory, and analgesic effects of ethanolic extract of red propolis. METHODS AND RESULTS: This extract induced the formation of granular layer in the mouse tail test used as a model of psoriasis. Propolis 50 mg.kg-1 i.g. showed anti-inflammatory activity in the cotton-pellet granuloma assay in rats, in croton oil-induced edema in mice at a dose of 25% (2.5 microL), and in the peritoneal capillary permeability test in mice at a dose of 10 mg.kg-1. The extract (25 mg.kg-1 i.g.) showed analgesic effect in the model of acetic acid-induced writhings, whereas 40 mg.kg-1 was effective in the hot plate test in mice. CONCLUSION: Anti-inflammatory, analgesic, and antipsoriatric properties of Cuban red propolis were evident.  (+info)

Endogenous nitric oxide in the maintenance of rat microvascular integrity against widespread plasma leakage following abdominal laparotomy. (6/3442)

1. The role of nitric oxide (NO) in the maintenance of microvascular integrity during minor surgical manipulation has been evaluated in the rat. 2. The NO synthase inhibitors, NG-nitro-L-arginine methyl ester (L-NAME, 5 mg kg(-1), s.c.) and N(G)-monomethyl-L-arginine (L-NMMA, 50 mg kg(-1), s.c.) had no effect on microvascular leakage of radiolabelled albumin over 1 h in the stomach, duodenum, jejunum, colon, lung and kidney in the un-operated conscious or pentobarbitone-anaesthetized rat. 3. In contrast, in anaesthetized rats with a midline abdominal laparotomy (5 cm), L-NAME (1-5 mg kg(-1), s.c.) or L-NMMA (12.5-50 mg kg(-1), s.c.) dose-dependently increased gastrointestinal, renal and pulmonary vascular leakage, effects reversed by L-arginine pretreatment (300 mg kg(-1), s.c., 15 min). These actions were not observed in anaesthetized rats that had only received a midline abdominal skin incision (5 cm). 4. Pretreatment with a rabbit anti-rat neutrophil serum (0.4 ml kg(-1), i.p.), 4 h before laparotomy, abolished the plasma leakage induced by L-NAME in all the organs investigated. 5. These results indicate that the following abdominal laparotomy, inhibition of constitutive NO synthase provokes vascular leakage in the general microcirculation, by a process that may involve neutrophils. Such effects could thus confound studies on the microvascular actions of NO synthase inhibitors using acute surgically prepared in vivo models. The findings thus suggest that constitutively-formed NO has a crucial role in the maintenance of acute microvascular integrity following abdominal surgical intervention.  (+info)

Neurogenic plasma leakage in mouse airways. (7/3442)

1. This study sought to determine whether neurogenic inflammation occurs in the airways by examining the effects of capsaicin or substance P on microvascular plasma leakage in the trachea and lungs of male pathogen-free C57BL/6 mice. 2. Single bolus intravenous injections of capsaicin (0.5 and 1 micromol kg(-1), i.v.) or substance P (1, 10 and 37 nmol kg(-10, i.v.) failed to induce significant leakage in the trachea, assessed as extravasation of Evans blue dye, but did induce leakage in the urinary bladder and skin. 3. Pretreatment with captopril (2.5 mg kg(-1), i.v.), a selective inhibitor of angiotensin converting enzyme (ACE), either alone or in combination with phosphoramidon (2.5 mg kg(-1), i.v.), a selective inhibitor of neutral endopeptidase (NEP), increased baseline leakage of Evans blue in the absence of any exogenous inflammatory mediator. The increase was reversed by the bradykinin B2 receptor antagonist Hoe 140 (0.1 mg kg(-1), i.v.). 4. After pretreatment with phosphoramidon and captopril, capsaicin increased the Evans blue leakage above the baseline in the trachea, but not in the lung. This increase was reversed by the tachykinin (NK1) receptor antagonist SR 140333 (0.7 mg kg(-1), i.v.), but not by the NK2 receptor antagonist SR 48968 (1 mg kg(-1), i.v.). 5. Experiments using Monastral blue pigment as a tracer localized the leakage to postcapillary venules in the trachea and intrapulmonary bronchi, although the labelled vessels were less numerous in mice than in comparably treated rats. Blood vessels of the pulmonary circulation were not labelled. 6. We conclude that neurogenic inflammation can occur in airways of pathogen-free mice, but only after the inhibition of enzymes that normally degrade inflammatory peptides. Neurogenic inflammation does not involve the pulmonary microvasculature.  (+info)

Enhancement of fluid filtration across tumor vessels: implication for delivery of macromolecules. (8/3442)

Cancer therapies using genes and other macromolecules might realize their full clinical potential if they could be delivered to tumor tissue in optimal quantities. Unfortunately, the compromised circulation within tumors poses a formidable resistance to adequate and uniform penetration of these agents. Previously, we have proposed elevated interstitial fluid pressure (IFP) as a major physiological barrier to delivery of macromolecules. Here we postulate that modulation of tumor microvascular pressure (MVP) and associated changes in IFP would enhance macromolecular delivery into a solid tumor. To test our hypothesis, we altered tumor MVP by either periodic injection or continuous infusion of angiotensin II (AII) and measured the resulting changes in IFP and uptake of macromolecules. We used the nicotinyl hydrazine derivative of human polyclonal IgG (HYNIC-IgG) as a nonspecific macromolecule and CC49 antibody as a specific macromolecule. We found that both chronic and periodic modulation of tumor MVP enhances transvascular fluid filtration, leading to a 40% increase in total uptake of the specific antibody within 4 hr of its administration. Conversely, neither continuous nor periodic infusion of AII induced any increase in uptake of nonspecific antibodies. Strategies to improve delivery of macromolecules and limitations of this approach are identified.  (+info)

Essay Topic:
Explain how Capillary Leak Syndrome (CLS) can cause severe fluid and electrolyte imbalances in the body, leading to potentially life-threatening complications.

Introduction:
Capillary Leak Syndrome (CLS) is a rare but potentially devastating condition that affects the blood vessels and can cause severe fluid and electrolyte imbalances in the body. These imbalances can lead to a range of symptoms, from mild discomfort to life-threatening complications. In this essay, we will explore how CLS can cause fluid and electrolyte imbalances and discuss the potential risks associated with this condition.

Fluid and Electrolyte Imbalances in CLS:
The hallmark of CLS is the leakage of fluid from the blood vessels into the surrounding tissues, leading to an excessive accumulation of fluid in the interstitial space. This can cause a range of symptoms, including swelling (edema), shortness of breath, and abdominal pain. However, the most severe complication of CLS is the development of electrolyte imbalances, which can lead to life-threatening complications if left untreated.

Electrolytes are essential minerals that regulate a range of bodily functions, including fluid balance, nerve function, and muscle contraction. When the blood vessels leak fluid into the interstitial space, they also lose electrolytes, leading to an imbalance in the body's electrolyte levels. This can cause a range of symptoms, including muscle weakness, heart arrhythmias, and seizures. In severe cases, electrolyte imbalances can lead to respiratory failure, cardiac arrest, and even death.

Potential Risks Associated with CLS:
The potential risks associated with CLS are numerous and can be severe. The most common complications of CLS include:

1. Respiratory failure: The excessive accumulation of fluid in the lungs can lead to respiratory failure, which can be life-threatening if left untreated.
2. Cardiac arrhythmias: Electrolyte imbalances can cause abnormal heart rhythms, which can lead to cardiac arrest and even death.
3. Seizures: The loss of electrolytes can cause seizures, which can be difficult to control and can lead to serious complications.
4. Kidney damage: Prolonged fluid accumulation in the body can put a strain on the kidneys, leading to permanent damage and even failure.
5. Infection: The presence of fluid in the body can provide a breeding ground for bacteria, leading to serious infections such as sepsis and meningitis.
6. Compartment syndrome: The accumulation of fluid in the muscles can cause compartment syndrome, a condition that can lead to permanent nerve and muscle damage if left untreated.
7. Gangrene: In severe cases, the lack of blood flow to the tissues can lead to gangrene, which is the death of body tissue due to lack of blood supply.
8. Amputations: In severe cases, the loss of blood flow and oxygen to the tissues can lead to the need for amputation of affected limbs.

It is important to note that these risks are not limited to CLS, but can also be associated with other conditions that cause fluid accumulation in the body. It is essential to seek medical attention immediately if any of these symptoms occur, as prompt treatment can help mitigate these risks and improve outcomes.

The symptoms of dermatitis, exfoliative include:

* Intense redness and scaling or blistering of the skin
* Itching, which can be severe
* Burning sensation on the skin
* Dry, rough skin that may flake off
* Small, raised bumps or hives on the skin
* Crusting or oozing of the skin

The diagnosis of dermatitis, exfoliative is based on the appearance of the skin and the patient's medical history. A skin biopsy may be performed to confirm the diagnosis and rule out other conditions. Treatment typically involves topical medications, such as corticosteroids or immunomodulators, and may also include oral medications or phototherapy.

In addition to these symptoms and treatments, it is important to note that dermatitis, exfoliative can be a chronic condition and may recur over time. It can also lead to complications such as skin infections or scarring. Therefore, it is important for individuals with this condition to work closely with their healthcare provider to manage their symptoms and prevent complications.

Symptoms of pulmonary edema may include:

* Shortness of breath (dyspnea)
* Coughing up frothy sputum
* Chest pain or tightness
* Fatigue
* Confusion or disorientation

Pulmonary edema can be diagnosed through physical examination, chest x-rays, electrocardiogram (ECG), and blood tests. Treatment options include oxygen therapy, diuretics, and medications to manage underlying conditions such as heart failure or sepsis. In severe cases, hospitalization may be necessary to provide mechanical ventilation.

Prevention measures for pulmonary edema include managing underlying medical conditions, avoiding exposure to pollutants and allergens, and seeking prompt medical attention if symptoms persist or worsen over time.

In summary, pulmonary edema is a serious condition that can impair lung function and lead to shortness of breath, chest pain, and other respiratory symptoms. Prompt diagnosis and treatment are essential to prevent complications and improve outcomes for patients with this condition.

There are several types of edema, including:

1. Pitting edema: This type of edema occurs when the fluid accumulates in the tissues and leaves a pit or depression when it is pressed. It is commonly seen in the skin of the lower legs and feet.
2. Non-pitting edema: This type of edema does not leave a pit or depression when pressed. It is often seen in the face, hands, and arms.
3. Cytedema: This type of edema is caused by an accumulation of fluid in the tissues of the limbs, particularly in the hands and feet.
4. Edema nervorum: This type of edema affects the nerves and can cause pain, numbness, and tingling in the affected area.
5. Lymphedema: This is a condition where the lymphatic system is unable to properly drain fluid from the body, leading to swelling in the arms or legs.

Edema can be diagnosed through physical examination, medical history, and diagnostic tests such as imaging studies and blood tests. Treatment options for edema depend on the underlying cause, but may include medications, lifestyle changes, and compression garments. In some cases, surgery or other interventions may be necessary to remove excess fluid or tissue.

OHSS typically occurs when too many eggs are stimulated to mature during ovulation, leading to an imbalance in hormone levels. The syndrome is more common in women who undergo IVF with high-dose fertility medications, multiple embryo transfer, or those with polycystic ovary syndrome (PCOS).

Symptoms of OHSS may include:

1. Enlarged ovaries that are painful to the touch
2. Abdominal bloating and discomfort
3. Pelvic pain
4. Nausea and vomiting
5. Diarrhea or constipation
6. Abnormal vaginal bleeding
7. Elevated hormone levels (estradiol and/or LH)

OHSS can be diagnosed through ultrasound and blood tests. Treatment options for OHSS include:

1. Cancellation of further fertility treatment until symptoms resolve
2. Medications to reduce hormone levels and inflammation
3. Ultrasound-guided aspiration of fluid from the ovaries
4. Hospitalization for monitoring and supportive care

Prevention is key, and fertility specialists take several measures to minimize the risk of OHSS, such as:

1. Monitoring hormone levels and ultrasound assessment of ovarian response during treatment
2. Adjusting medication dosages based on individual patient needs
3. Limited embryo transfer to reduce the risk of multiple pregnancies
4. Avoiding the use of high-dose stimulation protocols in women with PCOS or other risk factors

Early detection and proper management are crucial to prevent complications and ensure a successful outcome for fertility treatment. If you suspect you may have OHSS, it is essential to consult a fertility specialist immediately.

Note: This definition is intended for informational purposes only and should not be used to diagnose or treat a medical condition. If you suspect that you or your child may have a hemangioma, it is important to consult with a qualified healthcare professional for proper evaluation and treatment.

Schnitzer, J. E.; Oh, P. (1994). "Albondin-mediated capillary permeability to albumin. Differential role of receptors in ...
A hydrodynamic capillary effect can be used to manipulate cell permeability. In plants the DNA is often inserted using ...
Farquhar, M G; Wissig S L; Palade G E (December 1999). "Glomerular permeability I. Ferritin transfer across the normal ... glomerular capillary wall. 1961". Journal of the American Society of Nephrology. 10 (12): 2645-62. ISSN 1046-6673. PMID ...
The most interesting are: Capillary bed permeability, which varies between tissues. Blood-brain barrier: this is located ... The distribution of a drug between tissues is dependent on vascular permeability, regional blood flow, cardiac output and ...
Histamine causes dilation and increased permeability of capillaries close to the basophil. Injured basophils and other ... Increased permeability of the inflamed tissue also allows for more phagocyte migration to the site of infection so that they ...
Viberti, Giancarlo C. (1983-11-30). "Increased capillary permeability in diabetes mellitus and its relationship to ...
The injection of IP activators into the skin of rodents increases local capillary permeability and swelling; IP(-/-) mice fail ... IP antagonists likewise reduce experimentally-induced capillary permeability and swelling in rats. This actions is also ... to show this increased capillary permeability and swelling in response not only to IP activators but also in a model of ...
Also, the damage on the blood vessels resulted in increased capillary permeability. This increased permeability lead to a ...
In the acute phase of ALI, there is increased permeability of this barrier and protein rich fluid leaks out of the capillaries ... The direct toxicity to the cells leads to an increase in capillary permeability. Furthermore, when phosgene hydrolyzes it forms ... The core pathology is disruption of the capillary-endothelial interface: this actually refers to two separate barriers - the ...
It is a densely vascularized structure with subregional capillary specializations for high permeability for circulating blood ... A tanycyte barrier partially compensates for high capillary permeability in the area postrema. Physiological subregional ... whereas medial and dorsal area postrema capillaries had microscopic characteristics of high permeability, a characteristic ... Capillary blood flow appears to be uniquely slow in the area postrema, prolonging the contact time for blood-borne hormones to ...
Porosity Defining Permeability Tailoring porous media to control permeability Permeability of Porous Media Graphical depiction ... and Capillary Pressure from Pore-Scale Modeling". Transport in Porous Media. 102 (1): 71-90. doi:10.1007/s11242-013-0262-7. ... Reactive transport Permeability Porous media Filtration Poromechanics Bulk density Tang, H. P.; Wang, J.; Qian, Ma (1 January ... The intrinsic permeability is the attribute primarily influenced by the pore structure, and the fundamental physical factors ...
PDGF and VEGF have growth promoting properties and cause connective tissue hypertrophy and capillary permeability. When ... They are then trapped within the capillary beds within the extremities, such as the digits, and release platelet-derived growth ... megakaryocytes that arise from the bone marrow are trapped in the pulmonary capillary bed and broken down before they enter the ...
High protein (> 2.5 mg/dL) suggests increased capillary permeability associated with peritonitis, intestinal compromise, or ... Capillary refill time (CRT) may be decreased early in the colic, but generally prolongs as the disease progresses and ... The poor blood supply also has effects on the vascular endothelium, leading to an increased permeability which first leaks ... Inflammation of the bowel may lead to increased permeability and subsequent endotoxemia. The underlying cause of inflammation ...
In addition, brodifacoum (as with other anticoagulants in toxic doses) increases permeability of blood capillaries; the blood ...
It is a synthetic molecule with the ability to reduce capillary permeability in the body. In Switzerland the drug is sold by ... In fact, it reduces capillary permeability both by stabilizing the basement membrane for an action on the collagen chains that ... Calcium dobesilate is indicated in states of fragility and altered capillary permeability, e.g. diabetic retinopathy, chronic ... constitute it, and by interacting with different biochemical mediators that favor endothelial permeability itself. In this way ...
Reverses capillary permeability and lysosomal stabilization at the cellular level to prevent or control inflammation. Has a ...
Capillary Permeability: The Transfer of Molecules and Ions Between Capillary Blood and Tissue (C. ed.). Munksgaard: Copenhagen ... Betz, A.L.; Goldstein, G.W. "Brain capillaries: structure and function". In Lajtha, A. (ed.). Structural Elements of the ... Smith, Q.R. (1989). "Quantitation of blood-brain barrier permeability". In Neuwelt, E.A. (ed.). Implications of the Blood-Brain ...
Concerning two-phase flows an important problem is to estimate the relative permeabilities and the capillary pressures. The ... Chavent, Guy; Cohen, Gary; Espy, M. (1980). "Determination of relative permeabilities and capillary pressures by an automatic ... see for an application to the determination of permeabilities that match the existing permeability data), neural networks, ... Tahmasebi, Pejman; Javadpour, Farzam; Sahimi, Muhammad (August 2016). "Stochastic shale permeability matching: Three- ...
Capillary pressure Permeability (fluid) Relative permeability Darcy's law S.E. Buckley and M.C. Leverett (1942). "Mechanism of ... k r w ( S w ) {\displaystyle k_{rw}(S_{w})} and k r n ( S w ) {\displaystyle k_{rn}(S_{w})} denote the relative permeability ... Flow is linear and horizontal Both wetting and non-wetting phases are incompressible Immiscible phases Negligible capillary ...
The higher the specific gravity, the greater the likelihood of capillary permeability changes in relation to body cavities. For ...
The events preceding OM are acute inflammatory changes such as hyperemia, increased capillary permeability and infiltration of ...
It also inhibits the effects of the prostaglandin mediated vasodilatation and increased capillary permeability, thereby ... Etamsylate was also thought to stabilise capillaries, reinforcing capillary membranes by polymerising hyaluronic acid. ... vasodilation and increased capillary permeability. Prophylaxis and control of haemorrhages from small blood vessels, neonatal ... Etamsylate limits capillary bleeding through its action on hyaluronic acid and initial studies showed a reduction in ...
These changes are due to increased capillary permeability and an influx of inflammatory cells into the gingival tissues. When ...
IgE with Aspergillus antigens results in mast cell degranulation with bronchoconstriction and increased capillary permeability ...
Fluid from the bloodstream leaks through the wall of small blood vessels into body cavities due to capillary permeability. As a ... Severe disease is marked by the problems of capillary permeability (an allowance of fluid and protein normally contained within ... Leaky capillaries (and the critical phase) are thought to be caused by an immune system response. Other processes of interest ... Some petechiae (small red spots that do not disappear when the skin is pressed, which are caused by broken capillaries) can ...
... involves fluid accumulation in the outer plexiform layer secondary to abnormal perifoveal retinal capillary permeability. The ... causing the capillaries in the retina to dilate and leak fluid into the retina. Less common today with modern lens replacement ... is similarly caused by leaking macular capillaries. DME is the most common cause of visual loss in both proliferative, and non- ...
... water vapor permeability and capillary. They are lightweight , soft, flexible and silky texture. They are disposable and ...
... e increases the blood vessel's permeability and dilates capillaries, enabling a faster distribution of the venom. ... The dilation of capillaries is the cause of the hypotension. At first, it was thought that the impairment of the respiratory ... The formation of pores in capillaries, for example, is the cause of hypotension caused by stonefish envenomation. The venom of ...
Vasodilation and increased permeability of capillaries are a result of both H1 and H2 receptor types. Stimulation of histamine ... and vascular permeability in brain tumours. The mast cell is very similar in both appearance and function to the basophil, ... and increases blood vessel permeability. This leads to local edema (swelling), warmth, redness, and the attraction of other ... such as eosinophil chemotactic factor reactive oxygen species Histamine dilates post-capillary venules, activates the ...
... acts upon blood vessels and capillaries of the salivary gland to generate vasodilation and increased capillary permeability, ...
Furthermore, damage of arterioles and capillaries was found in brain tissue samples of people who died from COVID‑19. COVID‑19 ... The effect of the virus on ACE2 cell surfaces leads to leukocytic infiltration, increased blood vessel permeability, alveolar ... wall permeability, as well as decreased secretion of lung surfactants. These effects cause the majority of the respiratory ...
A flowmeter consisting of a long capillary is connected in series with the powder bed. The pressure drop across the flowmeter ( ... Measurement of air permeability can be performed very rapidly, and does not require the powder to be exposed to vacuum or to ... The air permeability specific surface of a powder material is a single-parameter measurement of the fineness of the powder. The ... In particular, air permeability is almost universally used in the cement industry as a gauge of product fineness which is ...
Colton, C. K.; Smith, K. A.; Merrill, E. W.; Farrell, P. C. (1971). "Permeability studies with cellulosic membranes". Journal ... and capillary tube viscometers". Journal of Applied Physiology. 25 (6): 786-9. doi:10.1152/jappl.1968.25.6.786. PMID 5727210. ...
Iqbal J (July 2011). "An enzyme immobilized microassay in capillary electrophoresis for characterization and inhibition studies ... "ameliorating intestinal permeability." Alkaline phosphatase is commonly used in the dairy industry as an indicator of ...
Since all the blood, within seconds, passes through 5-micrometre capillaries, any particles much larger than 5 micrometres ... and increased permeability. Lipoprotein LDL particles, which carry fats (including the fat cholesterol made by every human cell ... to pass on through the capillaries downstream. In this, the usual situation, the debris obstruct smaller downstream branches of ... the artery resulting in temporary to permanent end artery/capillary closure with loss of blood supply to, and death of, the ...
Activation of IP is associated with the promotion of capillary permeability in inflammation and allergic responses as well as ...
... batch washing for each cycle renews the heel and maintain the permeability, also extended heel life. Despite many advantages of ... to the vapour pressure of the filtrate liquid to overcome the wet layer of liquid over the surface of solid cake by capillary ...
... with continuous being the least porous of the three and discontinuous capillaries being extremely high in permeability. ... Continuous blood capillaries have the smallest intercellular clefts, with discontinuous blood capillaries having the largest ... However, most of this fluid returns into the capillary at the venous end, creating capillary fluid dynamics. Two opposing ... Most notably, intercellular clefts are described in capillary blood vessels. The three types of capillary blood vessels are ...
Air permeability method ISO 1137:1975 Plastics - Determination of behaviour in a ventilated tubular oven [Withdrawn without ... Determination of the viscosity of polymers in dilute solution using capillary viscometers ISO 1628-1:2021 Part 1: General ... Determination of permeability to gases - Constant volume method [Withdrawn: replaced with ISO 2782] ISO 1400:1975 Vulcanized ...
... which are able to move beyond the vascular system by migrating through the walls of capillary vessels and entering the areas ... products of the coagulation system can contribute to non-specific defenses via their ability to increase vascular permeability ...
... of the endothelium via these receptors have been indicated to impair critical immune responses and alter capillary permeability ... Endothelial cells are found in various tissue types such as in the capillaries, veins, and arteries in the human body. As ... Yuan, Sarah Y.; Rigor, Robert R. (2010). Signaling Mechanisms in the Regulation of Endothelial Permeability. Morgan & Claypool ... and barrier permeability. Given these vital functions, virus interactions with these receptors offers insight into the symptoms ...
... thereby leading to leakage into capillary beds, due to the increased pressure in the capillaries. Bradykinin is a ... It also causes contraction of non-vascular smooth muscle in the bronchus and gut, increases vascular permeability and is also ... November 2016). "Hyperfibrinolysis increases blood-brain barrier permeability by a plasmin- and bradykinin-dependent mechanism ...
... increasing the permeability of brain capillaries to elements of the blood's soluble elements) as well as promoting the movement ... increased vascular permeability, edema, influx of eosinophils and neutrophils, smooth muscle proliferation, collagen deposition ... LTD4 in stimulating GPR99-bearing cells with GPR99-deficient mice exhibiting a dose-dependent loss of vascular permeability ...
... , often in the form of capillary permeability or microvascular permeability, characterizes the capacity of ... An example of increased vascular permeability is in the initial lesion of periodontal disease, in which the gingival plexus ... Q J Exp Physiol Cms 59, 283-309 (1974). Bates, D. O. & Harper, S. J. Regulation of vascular permeability by vascular ... There are several techniques to measure vascular permeability to certain molecules. For instance, the cannulation of a single ...
... and for assessing relative permeability (the ability of a fluid to be transported in the presence of a second immiscible fluid ... Capillary pressure can also be utilized to block fluid flow in a microfluidic device. The capillary pressure in a microchannel ... Capillary pressure formulas are derived from the pressure relationship between two fluid phases in a capillary tube in ... see capillary action), resulting from the interactions of forces between the fluids and solid walls of the tube. Capillary ...
For this reason, progesterone and estrone have higher skin permeability, estradiol has moderate skin permeability, and estriol ... The exact levels of progesterone were 4 to 12 ng/mL in saliva and 62 to 96 ng/mL in capillary blood; the reference ranges of ... The transit time of red blood cells from capillaries and the release of steroid hormones from red blood cells are both very ... Skin permeability of a compound is based on its physicochemical properties, particularly lipophilicity and hydrophilicity. In ...
This occurs through the sprouting of new capillaries from post-capillary venules, requiring precise coordination of multiple ... This leads to vasodilatation and an increase in vascular permeability, leading to sprouting angiogenesis or intussusceptive ... Diabetic retinopathy, which can develop into proliferative diabetic retinopathy, is a condition where capillaries in the retina ...
Porosity Defining Permeability Tailoring porous media to control permeability Permeability of Porous Media Graphical depiction ... For the calculation of capillary imbibition speed of a liquid to an initially dry medium, Washburn's or Bosanquet's equations ... According to Darcy's law, the fluid's viscosity, effective fluid permeability, and fluid pressure gradient determine the flow ... liquid viscosity or permeability. However, the use of Darcy's law alone does not produce accurate results for heterogeneous ...
Typical preparation of a microscale electrode is performed by heat sealing a microwire or carbon fiber in a glass capillary ... it was the introduction of SECM that provided researchers an alternative method for exploring the permeability of monolayers to ... three dimensional mobility of the UME also affords spatial probing of membranes to identify points of high flux or permeability ... with sub-micron sized orifices replace the standard UME allowing femtoliter-sized droplets to be suspended from the capillary ...
The endocrine system secretes hormones directly into the bloodstream, typically via fenestrated capillaries, whereas the ... changes in ion channel permeability, or increased concentrations of intracellular molecules that may act as secondary ...
... obstructing capillary blood flow, hemorrhagic activity is caused by metalloproteases, which damage capillary walls, both ... The venom of Lachesis has several activities, such as the activation of plasminogen, leading to increased permeability of blood ...
Water content in a capillary fringe decreases with increasing distance from the phreatic surface. The capillary head depends on ... The term "perched" refers to ground water accumulating above a low-permeability unit or strata, such as a clay layer. This term ... by capillary action to saturate a small zone above the phreatic surface (the capillary fringe) at less than atmospheric ... The normal capillary rise in a clayey soil is less than 1.8 m (6 ft) but can range between 0.3 and 10 m (1 and 33 ft). The ...
Cytokines released in a large scale inflammatory response result in massive vasodilation, increased capillary permeability, ... activation causing systemic leukocyte adhesion and diffuse alveolar capillary damage in the lung, and activation of the ...
It is predicted, that two-phase transport properties such as the evolution of effective permeability as well as capillary ... Computer simulations were used to predict capillary pressure curves during drainage, which also agree with laboratory data. ... It is predicted, that two-phase transport properties such as the evolution of effective permeability as well as capillary ... 3D pore microstructures and computer simulation: Effective permeabilities and capillary pressure during drainage in Opalinus ...
Schisandrin A ameliorates increased pulmonary capillary endothelial permeability accompani Schisandrin A ameliorates increased ... The effect of SchA on pulmonary vascular permeability was examined in rat acute lung injury model. The effect of SchA on skin ... To evaluate the role and the underlying mechanism of SchA in increase of pulmonary vascular permeability induced by sepsis. ... The administration of SchA alleviated rat pulmonary endothelial dysfunction, relieved increased permeability in the mouse skin ...
Changes in pulmonary capillary permeability. An increase in capillary permeability can result in neurogenic pulmonary edema ... Whether the capillary leak is produced by pressure-induced mechanical injury because of the elevated capillary hydrostatic ... Changes in capillary hydrostatic pressure. Alterations in pulmonary vascular pressures appear to be the most likely Starling ... pressure or because of some direct nervous system control over the pulmonary capillary permeability remains uncertain. ...
Increased alveolar-capillary permeability is visible on electron microscopy.. Physiologic changes include the following:. * ...
Prednisone may decrease inflammation by reversing increased capillary permeability and suppressing the activity of ... Prednisolone decreases inflammation by suppressing migration of PMNs and reducing capillary permeability. Many practitioners ... Dexamethasone decreases airway inflammation by inhibiting migration of phagocytes and reversing capillary permeability, thereby ...
Increased capillary permeability (third-spacing and vasodilation) can result in hypovolemic shock. Sinus tachycardia can be an ... Arsenic has direct toxic effects on endothelial cells, increasing the permeability of small blood vessels (ATSDR 2005; HSDB ...
Categories: Capillary Permeability Image Types: Photo, Illustrations, Video, Color, Black&White, PublicDomain, ...
Pathogen-mediated injury to the vascular endothelium results in increased capillary permeability, microhemorrhage, and platelet ...
Increased capilliary permeability occurs in infections or as the result of toxin or inflammatory damage to the capillary walls ... Less often, edema results from decreased movement of fluid out of the interstitial space into the capillaries due to lack of ... from the intravascular to the interstitial space or decreased movement of water from the interstitium into the capillaries or ...
Increased vascular permeability of retinal capillaries. * Closure of retinal capillaries and arterioles. * Proliferation of new ... It is known that diabetes causes the retinal capillaries to become functionally less competent. Five clinical pathological ... Formation of microaneurysms (outpouchings of the capillary walls). * ...
Previous studies have suggested that immune responses contribute to an increase in capillary permeability. We examined the ...
Cholesterol in pleural exudates depends mainly on increased capillary permeability. Transl Res 2010;155:178-84.doi:10.1016/j. ... as a result of vascular leakage caused by obstructed lymph vessels and/or increased permeability of the affected serous ... 12 38 Disintegration of serosal cells and/or increased permeability can also occur in massive inflammatory conditions involving ...
bluing rate (increased capillary permeability) bleeding rate 3. Total score Total score (72 h reading) = dilating rate + ... bluing rate (increased capillary permeability) bleeding rate 3. Total score Total score (72 h reading) = dilating rate + ... bluing rate (increased capillary permeability) bleeding rate 3. Total score Total score (72 h reading) = dilating rate + ...
... reducing leukocyte adhesion to capillary endothelium; reducing capillary wall permeability and edema formation; decreasing ...
Model parameters were fit to both blood capillary permeability data and lymphatic clearance data. Small molecules are cleared ... The blood capillary component employed slit theory with contributions from both small (10 nm) and large (50 nm) slits. The ... The dermal clearance model combined with existing models for stratum corneum permeability and appropriate measures of protein ... When combined with existing models for stratum corneum permeability and appropriate measures of tissue binding, the developed ...
Unsteady Relative Permeability Measurement Considering Capillary Pressure and Saturation Profiles from Magnetic Resonance ... Evaluation of Permeability in Tight Sandstones of Eastern Saudi Arabia Based on Digital Rock Physics,. Ivan Deshenenkov and ... Calculation of Threshold Capillary Pressures from Irregular Pore Geometries Taken from Unconventional Reservoir Rock Images,. ... NMR Imaging Elucidates Fluid Flow in Ultra low Permeability Unconventional Reservoir Rocks,. Jinhong Chen, Hui-Hai Liu, Stacey ...
Blood-spinal cord barrier pericyte reductions contribute to increased capillary permeability. J Cereb Blood Flow Metab. 2012;32 ... Permeability of the blood-brain and blood-spinal cord barriers to interferons. J Neuroimmunol. 1997;76(1-2):105-111.. View this ... Antibodies with a high affinity for TfR preferentially accumulate in brain capillaries but do not release efficiently to the ... The BBB is not homogenous throughout the CNS, and differences in permeability may allow the targeted passage into specific ...
Increased Capillary Permeability in Haemophilia and Afibrinogenaemia: Possible Involvement of Anti-Haemophilic Factors and ...
1999) Glomerular permeability I. Ferritin transfer across the normal glomerular capillary wall. 1961. Journal of the American ...
... capillary sorption describes permeability of concrete where the pressure head is replaced by the capillary forces including ... Gas permeability was in the range of 0.1 × 10− 9 m/s , ke , 10 × 10-9 m/s. The gas permeability decreased with decreasing w/b ... Hall C (2019) Capillary imbibition in cement-based materials with time-dependent permeability. Cement Concr Res 124:105835. ... Moisture transport (sorption, capillary suction and water permeability) strongly depends on the initial moisture conditions. ...
... hypercoagulation and increased capillary permeability. Diabetes, which is also characterised by vascular injury in itself, ... Capillary glucose, medication use, creatinine and demographic data were collected. As drugs may be discontinued/not ...
The porosity, permeability, and capillary force of porous sintered copper were examined in relation to the effects of copper ... The porosity, permeability, and capillary force of porous sintered copper were examined in relation to the effects of copper ... To investigate the capillary force of the sintered foam, a test was conducted using a raised meniscus test device. As more ... The Study of Copper Powder Sintering for Porous Wick Structures with High Capillary Force by Im-Nam Jang ...
... with boiling points measured at bulk conditions to investigate the deviation between the phase-change temperatures in capillary ... The capillary characteristics of the rocks such as permeability, pore texture, wettability, and clay content may also play a ... Table 2 Permeability, density, and pore volume percentages in various tested reservoir rocks (Al-Kindi and Babadagli6).. Full ... Several studies8,9,10,11,12 were conducted to apply the notion of capillary (or confinement) effect in the original cubic EoS. ...
Capillary permeability (Review article). Am. J. Med. Sci. 172:463-68.. 1927 Micro-injection studies of capillary permeability. ... 1928 Micro-injection studies of capillary permeability. III. The effects of lack of oxygen on the permeability of the capillary ... Capillary permeability and the factors affecting the composition of capillary filtrates. Symposium on Lymph. Ann. N. Y. Acad. ... 1934 Capillary pressure and capillary permeability. Physiol. Rev. 14:404-81.. Observations on the diagnosis and treatment of ...
  • To evaluate the role and the underlying mechanism of SchA in increase of pulmonary vascular permeability induced by sepsis . (bvsalud.org)
  • The effect of SchA on pulmonary vascular permeability was examined in rat acute lung injury model. (bvsalud.org)
  • The effect of SchA on skin vascular permeability of mice was investigated through Miles assay. (bvsalud.org)
  • peritoneal fluid accumulation is a common finding in many children with abdominal disorders and its generation secondary to increased vascular permeability. (bvsalud.org)
  • The purpose of the present study as to evaluate the effect of changes in intravascular pressure and the inflammatory mediator bradykinin on rat mesenteric arterial and venous vascular permeability. (bvsalud.org)
  • Vascular permeability to dextran was determined at 100, 200 and 300 % of physiological pressures. (bvsalud.org)
  • vascular permeability was present at all measurements for both vessels and its magnitude directly proportional to the intravascular pressure. (bvsalud.org)
  • 1999 ) Glomerular permeability I. Ferritin transfer across the normal glomerular capillary wall. (academictree.org)
  • Specifically, these studies have implicated transient renal ischemia, direct renal tubular toxicity and changes in glomerular capillary permeability as possible mediators of RCIN, and these pathophysiologic mechanisms are not mutually exclusive. (elsevier.com)
  • The blood capillary component employed slit theory with contributions from both small (10 nm) and large (50 nm) slits. (cdc.gov)
  • Model parameters were fit to both blood capillary permeability data and lymphatic clearance data. (cdc.gov)
  • Schisandrin A ameliorates increased pulmonary capillary endothelial permeability accompanied with sepsis through inhibition of RhoA/ROCK1/MLC pathways. (bvsalud.org)
  • Dexamethasone decreases airway inflammation by inhibiting migration of phagocytes and reversing capillary permeability, thereby reducing the edema that occurs in croup. (medscape.com)
  • Edema results from increased movement of fluid from the intravascular to the interstitial space or decreased movement of water from the interstitium into the capillaries or lymphatic vessels. (msdmanuals.com)
  • Less often, edema results from decreased movement of fluid out of the interstitial space into the capillaries due to lack of adequate plasma oncotic pressure as in nephrotic syndrome, protein-losing enteropathy, liver failure, or starvation. (msdmanuals.com)
  • It is predicted, that two-phase transport properties such as the evolution of effective permeability as well as capillary pressures during drainage depend both on transport directions, which should be considered for Opalinus Clay when assessing its suitability as host rock for nuclear waste. (ejp-eurad.eu)
  • A central nervous system event produces a dramatic change in Starling forces, which govern the movement of fluid between capillaries and the interstitium. (medscape.com)
  • The administration of SchA alleviated rat pulmonary endothelial dysfunction, relieved increased permeability in the mouse skin and HUVECs induced by lipopolysaccharide (LPS). (bvsalud.org)
  • In summary, our results indicate that SchA ameliorates the increase of pulmonary endothelial permeability induced by sepsis through inhibition of RhoA/ROCK1/MLC pathway, providing a potentially effective therapeutic strategy for sepsis . (bvsalud.org)
  • Systemic capillary leak syndrome (SCLS) is an ex- of Zika virus in Brazil and the Americas. (cdc.gov)
  • Causes of rupture of the capillaries foremost to IVH shift and subsume fluctuations in systemic and cerebral blood go, increases in cerebral blood purl from hypertension, intravenous infusion, spasm activity, increases in cerebral venous pressurize due to vaginal delivery, hypoxia, and respiratory distress. (daubnet.com)
  • Increased capilliary permeability occurs in infections or as the result of toxin or inflammatory damage to the capillary walls. (msdmanuals.com)
  • Dr. Jacobs, in reply, suggested that Gene investigate the permeability of capillary walls using synthetic dyes. (nationalacademies.org)
  • First, August Krogh had just published his Nobel prize-winning book, Anatomy and Physiology of the Capillaries , in which he emphasized the quantitative histology of the capillary network and pointed out how little was known about the permeability of capillary walls. (nationalacademies.org)
  • The vaporization temperatures were measured experimentally in each rock type and compared with boiling points measured at bulk conditions to investigate the deviation between the phase-change temperatures in capillary media and bulk values. (nature.com)
  • Previous studies have suggested that immune responses contribute to an increase in capillary permeability. (who.int)
  • Histamine binds to the H1 receptor in target cells to contract gut and bronchus smooth muscle and to increase venular permeability and rheum ( 6 ). (spandidos-publications.com)
  • Since, studies have confirmed that blueberries increase capillary resistance and thus decrease redness. (alchimie-forever.com)
  • Prednisone may decrease inflammation by reversing increased capillary permeability and suppressing the activity of polymorphonuclear leukocytes (PMNs). (medscape.com)
  • Histamine increases the permeability of capillaries to white blood cells and various proteins to allow them to engage pathogens in the infected tissue ( 6 ). (spandidos-publications.com)
  • Prednisolone decreases inflammation by suppressing migration of PMNs and reducing capillary permeability. (medscape.com)
  • Swedana Karma hastens this process by increasing the permeability of capillary and bringing the morbidities into an extracellular fluid by dilating and clearing the channels of the body. (who.int)
  • year medical student-sent a long manuscript entitled "The Capillary Pressure in Frog Mesentery Determined by Microinjection Methods" to the editors of the American Journal of Physiology . (nationalacademies.org)
  • Computer simulations were used to predict capillary pressure curves during drainage, which also agree with laboratory data. (ejp-eurad.eu)
  • The dermal clearance model combined with existing models for stratum corneum permeability and appropriate measures of protein binding were used to analyze in vivo concentration data from the literature and compare it to predictions made by the current mathematical model. (cdc.gov)
  • Blueberries play a role in the management of flushing symptoms: they tighten and protect fine capillaries thanks to anthocyanins , [2] and are thus ideal in skin care products targeting redness-prone skin. (alchimie-forever.com)
  • When combined with existing models for stratum corneum permeability and appropriate measures of tissue binding, the developed model has the potential to significantly improve tissue concentration estimates for large or highly protein bound permeants following dermal exposure. (cdc.gov)
  • Systemic capillary leak syndrome (SCLS) is an ex- of Zika virus in Brazil and the Americas. (cdc.gov)
  • The systemic capillary leak syndrome (SCLS) is an extremely rare disorder characterized by transient episodes of hypotensive shock due to reversible vascular hyper-permeability. (nih.gov)
  • Intravenous immunoglobulin (IVIG), one promising therapy for SCLS, mitigated the permeability effect of episodic sera. (nih.gov)
  • Two circulating permeability factors, VEGF and Angiopoietin 2 (Ang2), were significantly elevated in episodic SCLS sera. (nih.gov)
  • Previous studies have suggested that immune responses contribute to an increase in capillary permeability. (who.int)