Capillary Leak Syndrome
Capillary Permeability
The property of blood capillary ENDOTHELIUM that allows for the selective exchange of substances between the blood and surrounding tissues and through membranous barriers such as the BLOOD-AIR BARRIER; BLOOD-AQUEOUS BARRIER; BLOOD-BRAIN BARRIER; BLOOD-NERVE BARRIER; BLOOD-RETINAL BARRIER; and BLOOD-TESTIS BARRIER. Small lipid-soluble molecules such as carbon dioxide and oxygen move freely by diffusion. Water and water-soluble molecules cannot pass through the endothelial walls and are dependent on microscopic pores. These pores show narrow areas (TIGHT JUNCTIONS) which may limit large molecule movement.
Hypoproteinemia
Lymphoma, Large B-Cell, Diffuse
Malignant lymphoma composed of large B lymphoid cells whose nuclear size can exceed normal macrophage nuclei, or more than twice the size of a normal lymphocyte. The pattern is predominantly diffuse. Most of these lymphomas represent the malignant counterpart of B-lymphocytes at midstage in the process of differentiation.
Evidence for a structural motif in toxins and interleukin-2 that may be responsible for binding to endothelial cells and initiating vascular leak syndrome. (1/91)
The dose-limiting toxicity of interleukin-2 (IL-2) and immunotoxin (IT) therapy in humans is vascular leak syndrome (VLS). VLS has a complex etiology involving damage to vascular endothelial cells (ECs), extravasation of fluids and proteins, interstitial edema, and organ failure. IL-2 and ITs prepared with the catalytic A chain of the plant toxin, ricin (RTA), and other toxins, damage human ECs in vitro and in vivo. Damage to ECs may initiate VLS; if this damage could be avoided without losing the efficacy of ITs or IL-2, larger doses could be administered. In this paper, we provide evidence that a three amino acid sequence motif, (x)D(y), in toxins and IL-2 damages ECs. Thus, when peptides from RTA or IL-2 containing this sequence motif are coupled to mouse IgG, they bind to and damage ECs both in vitro and, in the case of RTA, in vivo. In contrast, the same peptides with a deleted or mutated sequence do not. Furthermore, the peptide from RTA attached to mouse IgG can block the binding of intact RTA to ECs in vitro and vice versa. In addition, RTA, a fragment of Pseudomonas exotoxin A (PE38-lys), and fibronectin also block the binding of the mouse IgG-RTA peptide to ECs, suggesting that an (x)D(y) motif is exposed on all three molecules. Our results suggest that deletions or mutations in this sequence or the use of nondamaging blocking peptides may increase the therapeutic index of both IL-2, as well as ITs prepared with a variety of plant or bacterial toxins. (+info)Intrapulmonary protein leakage in immunocompromised children and adults with pneumonia. (2/91)
BACKGROUND: Pulmonary infections are associated with an increase in capillary permeability but information regarding age related differences in the local inflammatory response is lacking. To quantify the degree of capillary leakage during inflammation, the concentrations of the plasma proteins albumin, alpha1-antitrypsin, alpha2-macroglobulin and the locally produced proteins elastase, myeloperoxidase, lactoferrin and fibronectin were studied in the bronchoalveolar lavage (BAL) fluid of immunosuppressed children and adults with pneumonia. METHODS: Sixteen children aged 2-16 years and 15 adults who developed pneumonia while receiving immunosuppressive therapy for haematological malignancies were included in the study. Bronchoalveolar lavage was performed via a flexible bronchoscope with three aliquots of 1 ml/kg body weight in children and 200 ml in adults. Protein concentrations in BAL fluid were determined using highly sensitive immunoluminometric assays. RESULTS: Despite considerable variability, the median concentrations of all proteins in BAL fluid were significantly higher in both patient populations than in previously collected age adjusted reference values. The concentrations of serum derived proteins were significantly higher in children with pneumonia than in adult patients. In contrast, no differences were observed between the two groups for locally produced proteins. CONCLUSIONS: These data suggest that the degree of protein exudation is more pronounced in immunosuppressed children with pneumonia than in adults in a similar clinical situation. This is in agreement with our studies in healthy individuals and may reflect a greater permeability of the alveolar-capillary membrane in children, regardless of disease status. (+info)Evidence for the involvement of CD44 in endothelial cell injury and induction of vascular leak syndrome by IL-2. (3/91)
At sites of chronic inflammation seen during infections, autoimmunity, graft-vs-host response, and cytokine therapy, endothelial cell injury is known to occur, the exact mechanism of which is unknown. In the current study we used IL-2-induced vascular leak syndrome (VLS) as a model to investigate whether cytotoxic lymphocytes use CD44 in mediating endothelial cell injury. Administration of IL-2 to wild-type mice triggered significant VLS in the lungs and liver. In contrast, in CD44 knockout (KO) mice, IL-2-induced VLS was markedly reduced in the lungs and liver. IL-2-treated wild-type and CD44 KO mice had similar levels of perivascular infiltration with lymphocytes in the lungs and liver. This suggested that the decrease in VLS seen in CD44 KO mice was not due to the inability of lymphocytes to migrate to these organs. Ultrastructural studies demonstrated extensive endothelial cell damage in the lungs and liver of IL-2-treated wild-type, but not CD44 KO, mice. Moreover, CD44-KO mice exhibited a marked decrease in IL-2-induced lymphokine-activated killer cell activity. The induction of VLS was dependent on the expression of CD44 on immune cells rather than endothelial cells because adoptive transfer of CD44+, but not CD44- spleen cells along with IL-2 into CD44 KO mice triggered VLS. The IL-2-induced VLS was blocked by administration of F(ab')2 of Abs against CD44. The current study demonstrates that CD44 plays a key role in endothelial cell injury. Blocking CD44 in vivo may offer a novel therapeutic approach to prevent endothelial cell injury by cytotoxic lymphocytes in a variety of clinical disease models. (+info)Acute modulation of albumin microvascular leakage by advanced glycation end products in microcirculation of diabetic rats in vivo. (4/91)
Advanced glycation end products (AGEs) are nonenzymatic glycosylated adducts of proteins that accumulate in vascular tissue during diabetes and aging. The aim of this work was to study the role of AGEs and of the oxidative mechanisms in diabetes-induced changes in vascular permeability. Intravital videomicroscopy was used to study albumin microvascular leakage in cremaster muscle. The extravasation of a fluorescent macromolecular tracer (fluorescein isothiocyanate-albumin) was measured for 1 h and, after computer-aided image analysis, was expressed as variations of normalized gray levels (arbitrary units). Extravasation of the macromolecular tracer was much higher in diabetic rats than in control rats (slope of extravasation versus time increased by >100%, P < 10(-4)). This increase was significantly inhibited when we blocked AGEs binding to their endothelial receptor by intravenous bolus of soluble recombinant receptor to AGEs (rR-RAGE) (slope of extravasation versus time decreased by 19, 30, and 40%, for 0.5, 2.5, and 5.15 mg/kg rR-RAGE, respectively) or by a 6 mg/kg intravenous bolus of antibody against RAGE (slope decreased by 53%). Systemic injection of probucol (an antioxidant) also significantly inhibited the increase in the extravasation of the macromolecular tracer occurring in experimental diabetes (slope decreased by 51%, P < 10(-4)). These results strongly suggest that in experimental diabetes the interaction of circulating AGEs and endothelial RAGE mediates albumin micro-vascular leakage, possibly via AGE-RAGE-dependent enhanced oxidant stress. (+info)Adjuvant treatment of severe acute pancreatitis with C1 esterase inhibitor concentrate after haematopoietic stem cell transplantation. (5/91)
BACKGROUND: With an incidence of 4%, acute pancreatitis is a common complication of bone marrow or peripheral haematopoietic stem cell transplantation, which contributes significantly to morbidity and mortality in these patients. In most cases, the pathogenesis of acute pancreatitis cannot be attributed to a single pathogenetic factor, as treatment toxicity, acute graft versus host disease, infection, and cholestasis may all contribute. Acute pancreatitis is characterised by inflammation and activation of digestive proenzymes leading to autodigestive destruction of the pancreas and systemic activation of protease cascades including the complement system. AIM: To describe the effects of human C1 esterase inhibitor in two children, who developed severe acute pancreatitis with considerable complement activation after allogeneic haematopoietic stem cell transplantation. METHODS: Both children showed clinical features resembling those observed in capillary leakage syndrome. In both patients, treatment with C1 esterase inhibitor concentrate contributed to a rapid clinical stabilisation. CONCLUSIONS: These observations strongly support the proposed pathophysiological concept that early treatment with C1 esterase inhibitor interferes with the activation of the complement system in acute pancreatitis. Inhibition of complement activation prevents its adverse effects on vascular function and permeability, and thus stabilises intravascular fluid status and prevents multiorgan failure in acute pancreatitis. (+info)Effect of endothelin and endothelin receptor blockade on capillary permeability in experimental pancreatitis. (6/91)
BACKGROUND: Capillary leakage with fluid loss into the third space contributes to many of the early systemic complications in severe acute pancreatitis. There has been increasing interest in endothelin as one of the factors affecting capillary permeability. AIM: To elucidate further the role of endothelin in the development of capillary leakage in acute pancreatitis by investigating the effect of exogenous endothelin administration and endothelin receptor blockade in sham operated animals and two models of acute pancreatitis. METHODS: Determination of capillary permeability in the pancreas and colonic mucosa by quantifying extravasation of fluorescein labelled dextran using a novel computer assisted video image analysis system. RESULTS: Pancreatic and colonic capillary permeability increased stepwise from mild to severe acute pancreatitis. Endothelin increased pancreatic and colonic capillary permeability in healthy animals and animals with mild acute pancreatitis but had no additional adverse effect in severe acute pancreatitis. Endothelin receptor blockade decreased pancreatic capillary permeability in sham operated rats but had no effect on the colon. In mild and severe acute pancreatitis, endothelin receptor blockade stabilised increased capillary permeability in both the pancreas and colon. CONCLUSIONS: Endothelin plays an important role in mediating capillary permeability in the pancreas. In severe pancreatitis, it increases capillary permeability even outside the pancreas, thereby contributing to capillary leakage. Endothelin receptor blockade significantly reduces capillary permeability in acute pancreatitis both in and outside the pancreas, suggesting a therapeutic approach to counteract capillary leakage in severe acute pancreatitis. (+info)Sensitive blood-retinal barrier breakdown quantitation using Evans blue. (7/91)
PURPOSE: This study investigated whether a nonradioactive dye, Evans blue, can be adapted as a safe alternative to the isotope-dilution method for quantitating blood-retinal barrier breakdown. METHODS: Blood-retinal barrier breakdown was induced in rats with vascular endothelial growth factor (VEGF) or through the induction of diabetes. After allowing Evans blue to circulate in the vasculature, the dye was cleared from the bloodstream with saline, citrate, or citrate-buffered paraformaldehyde, and the efficacies of the perfusion solutions were compared. Extravasated dye was detected at 620 nm and was normalized against the time-averaged Evans blue plasma concentration, the circulation time, and also against wet and dry retina weights. RESULTS: Evans blue leakage from retinas treated with VEGF was 4.0-fold higher than that of contralateral untreated eyes (n = 6 rats, P: < 0.05). Retinal Evans blue leakage of eyes from 1-week diabetic animals (n = 11 retinas) was 1.7-fold higher (P: < 0.05) than that of nondiabetic controls (n = 10 retinas). Intra-animal, inter-retina weights showed significantly less variability (P: < 0.05) with the use of dry weights (11.2%, n = 74 retina pairs) than with wet weights (20.5%, n = 93 retina pairs). CONCLUSIONS: The Evans blue dye technique can be modified to be as sensitive and quantitative as the isotope-dilution method for measuring blood-retinal barrier breakdown. The advantages of the Evans blue technique are its safety, relative simplicity, and economy. (+info)The toxicity of deglycosylated ricin A chain-containing immunotoxins in patients with non-Hodgkin's lymphoma is exacerbated by prior radiotherapy: a retrospective analysis of patients in five clinical trials. (8/91)
A retrospective analysis of 102 patients with relapsed, non-Hodgkin's lymphoma treated with two different ricin A chain-containing immunotoxins (ITs) in five Phase I clinical trials indicates that the dose-limiting toxicity, vascular leak syndrome, was more frequent and more severe in patients who had undergone prior radiotherapy (RT). Excluding patients with prior RT from the calculations of the maximum tolerated dose indicates that the maximum tolerated doses of these ITs had not been reached in any trial and are clearly higher than reported previously. Excluding patients with prior RT from future clinical trials may increase the dose of ITs that can be given in the absence of severe vascular leak syndrome. (+info)
Capillary Leak Syndrome | definition of Capillary Leak Syndrome by Medical dictionary
Capillary leak syndrome - Wikipedia
Systemic Capillary Leak Syndrome
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Treatment of lung cancer
... and adult respiratory distress syndrome; capillary leak syndrome; and posterior reversible encephalopathy syndrome. Pemetrexed ...
Interleukin 2
The most common adverse effect of high-dose IL-2 therapy is vascular leak syndrome (VLS; also termed capillary leak syndrome). ... a process mechanistically similar to the vascular leakage syndrome, occurs in tumor tissue only. Disruption of the blood flow ... "Low Dose Interleukin-2 in Patients With Stable Ischaemic Heart Disease and Acute Coronary Syndromes (LILACS)" at ClinicalTrials ...
Polycythemia vera
Capillary leak syndrome Hematopoietic ulcer "polycythemia vera." at Encyclopædia Britannica. 2010. Encyclopædia Britannica ... Capillaries can become plugged by the very viscous blood, and the flow of blood through the vessels tends to be extremely ... 10 June 2011). "Treatment-related risk factors for transformation to acute myeloid leukemia and myelodysplastic syndromes in ... or Budd-Chiari syndrome) may sometimes be the first symptom or indication that a person has polycythemia vera. Headaches, lack ...
Gemcitabine
The warning label also states it may cause posterior reversible encephalopathy syndrome, that it may cause capillary leak ... ISBN 978-0-470-09254-5. Siddall E, Khatri M, Radhakrishnan J (July 2017). "Capillary leak syndrome: etiologies, pathophysiology ... syndrome, that it may cause severe lung conditions like pulmonary edema, pneumonia, and adult respiratory distress syndrome, ...
Mehmet Ali Erbil
He currently suffers from a rare disease called capillary leak syndrome. His TV show Çarkıfelek (Turkey's version of Wheel of ...
Targeted molecular therapy for neuroblastoma
These toxicities include neuropathic pain, capillary leak syndrome, and hypersensitivity reaction. Anti-GD2 antibodies have ...
Moxetumomab pasudotox
Symptoms of capillary leak syndrome include difficulty breathing, weight gain, hypotension, or swelling of arms, legs and/or ... prescribing information for moxetumomab pasudotox includes a boxed warning about the risk of developing capillary leak syndrome ... The boxed warning also notes the risk of hemolytic uremic syndrome, a condition caused by the abnormal destruction of red blood ... a condition in which fluid and proteins leak out of tiny blood vessels into surrounding tissues. ...
Anasarca
Semb K A, Aamdal S, Oian P. "Capillary protein leak syndrome appears to explain fluid retention in cancer patients who receive ... cause anasarca through a poorly understood capillary leak syndrome.[2] In Hb Barts, the high oxygen affinity results in poor ...
Acute promyelocytic leukemia
The etiology of retinoic acid syndrome has been attributed to capillary leak syndrome from cytokine release from the ... ATRA therapy is associated with the unique side effect of differentiation syndrome. This is associated with the development of ...
Arturo Porzecanski
... honored by the White House Systemic Capillary Leak Syndrome website on RareShare.org Bhanoo, Sindya N. " ... Since late 2005, Porzecanski has struggled with an exceedingly rare illness, Systemic Capillary Leak Syndrome (SCLS), which ... He also persuaded the National Institutes of Health to carry out basic biomedical research on this syndrome. In early 2009, ...
Hematocrit
Capillary leak syndrome also leads to abnormally high hematocrit counts, because of the episodic leakage of plasma out of the ... In order to maintain pressure, the capillaries branch off to a web of vessels that carry blood into the venules. Through this ... As blood flows through the arterioles, red cells will act a feed hematocrit (Hf), while in the capillaries, a tube hematocrit ( ... The packed cell volume (PCV) can be determined by centrifuging EDTA-treated or heparinized blood in a capillary tube (also ...
Sargramostim
... capillary leak syndrome, a build up of fluid around the lungs and around the heart. Irregular heart rhythms have occurred, ... In March 2018 the label was extended to use as a countermeasure for acute radiation syndrome. "US Sargramostim label" (PDF). ... FDA approves Leukine for Acute Radiation Syndrome. Retrieved 29 March 2018.. ...
Viral hemorrhagic fever
The "VHF syndrome" (capillary leak, bleeding diathesis, and circulatory compromise leading to shock) appears in a majority of ... Olson PE, Hames CS, Benenson AS, Genovese EN (1996). "The Thucydides syndrome: Ebola déjà vu? (or Ebola reemergent?)". Emerging ... The former family Bunyaviridae includes the causative agents of Hantavirus hemorrhagic fever with renal syndrome (HV-HFRS) ( ...
Lipopolysaccharide
Damage to the endothelial layer of blood vessels caused by these inflammatory mediators can lead to capillary leak syndrome, ... have also been implicated with Guillain-Barré syndrome and a variant of Guillain-Barré called Miller-Fisher syndrome.[11] ... Waterhouse-Friderichsen syndrome, and meningitis. Alkaline phosphatase prevents intestinal inflammation (and "leaky gut") from ... which is likely to develop on the basis of the small bowel bacterial overgrowth syndrome and an increased intestinal ...
POEMS syndrome
While some reports were positive, others have reported capillary leak syndrome suspected to be the result of overly rapid ... POEMS syndrome (also termed osteosclerotic myeloma, Crow-Fukase syndrome, Takatsuki disease, or PEP syndrome) is a rare ... Some features have been observed in patients with POEMS syndrome but are not yet certain to form part of the syndrome itself. ... afflicted by POEMS syndrome. The diagnosis of POEMS syndrome is based on meeting its two mandatory criteria, meeting at least ...
Retinoic acid syndrome
Several causes have been speculated, including a capillary leak syndrome from cytokine release from the differentiating myeloid ... "Differentiation (retinoic acid) syndrome". Retrieved 10 March 2011. Tallman MS (February 2002). "Retinoic acid syndrome: a ... and to an increasing use of the term differentiation syndrome to signify this APML treatment complication. The syndrome is ... Retinoic acid syndrome (RAS) is a potentially life-threatening complication observed in patients with acute promyelocytic ...
List of diseases (C)
... syndrome Cantu-Sanchez-Corona-Garcia syndrome Cantu-Sanchez-Corona-Hernandes syndrome Capillary leak syndrome Capillary leak ... CCA syndrome Ccge syndrome CCHS CDG syndrome type 1A CDG syndrome type 1B CDG syndrome type 1C CDG syndrome type 2 CDG syndrome ... syndrome Coffin-Siris syndrome COFS syndrome Cogan-Reese syndrome Cogan syndrome Cohen-Gibson syndrome Cohen-Hayden syndrome ... syndrome type 1 Cockayne syndrome type 2 Cockayne syndrome type 3 Cockayne's syndrome Codas syndrome Codesette syndrome Coeliac ...
SCLS
Capillary leak syndrome a rare medical condition where the number and size of the pores in the capillaries are increased which ...
Dinutuximab
... and capillary leak syndrome. Other common adverse effects include retention or urine for weeks to months after receiving the ...
Tagraxofusp
In addition, the medicine could cause capillary leak syndrome (an unpredictable, potentially life-threatening side effect due ...
Clostridium sordellii
... persistent apyrexia and profound capillary leak syndrome (see entry for Clostridium novyi alpha-toxin for details of mechanism ... Severe toxic shock syndrome among previously healthy persons has been described in a small number of C. sordellii cases, most ...
Polycythemia
... a decrease in blood cell count Capillary leak syndrome, another cause of hemoconcentration "absolute polycythemia" at Dorland's ... A specific type of relative polycythemia is Gaisböck syndrome. In this syndrome, primarily occurring in obese men, hypertension ... Stefanini, Mario; Urbas, John V.; Urbas, John E. (July 1978). "Gaisböck's syndrome: its hematologic, biochemical and hormonal ... a so-called myeloproliferative syndrome), or it may be a reaction to chronically low oxygen levels or, rarely, a malignancy. ...
Gleich's syndrome
... but it is unrelated to capillary leak syndrome (which may cause similar swelling episodes) and eosinophilia-myalgia syndrome ( ... Gleich's syndrome is not a form of the idiopathic hypereosinophilic syndrome in that there is little or no evidence that it ... Gleich syndrome has a good prognosis. Attack severity may improve with steroid treatment. Gleich GJ, Schroeter AL, Marcoux JP, ... Gleich's syndrome is a rare disease in which the body swells up episodically (angioedema), associated with raised antibodies of ...
Capillary leak syndrome
Systemic capillary leak syndrome (SCLS), also called Clarkson's disease, or primary capillary leak syndrome, is a rare, grave ... can also cause capillary leaks. These conditions and factors are sources of secondary capillary leak syndrome. ... Capillary leak syndrome is characterized by the escape of blood plasma through capillary walls, from the blood circulatory ... engraftment syndrome, hemophagocytic lymphohistiocytosis, the ovarian hyperstimulation syndrome, viral hemorrhagic fevers, and ...
Urticarial syndromes
Muckle-Wells syndrome Familial Mediterranean fever Systemic capillary leak syndrome Physical urticarias List of cutaneous ... There are several distinct urticarial syndromes including: ...
List of syndromes
Cantú syndrome Capgras delusion Capgras syndrome Capillary leak syndrome Caplan's syndrome Carcinoid syndrome Cardiac syndrome ... syndrome Wende-Bauckus syndrome Werner syndrome Wernicke-Korsakoff syndrome West syndrome Westerhof syndrome Wet lung syndrome ... syndrome Lynch Syndrome Lyngstadaas syndrome Löffler's syndrome Löfgren syndrome M74 syndrome Macrocephaly-capillary ... syndrome Shone's syndrome Short anagen syndrome Short bowel syndrome short limb syndrome Short man syndrome Short QT syndrome ...
Irvine-Gass syndrome
... causing the capillaries in the retina to dilate and leak fluid into the retina. This is less common today with modern lens ... The syndrome is named in honor of S. Rodman Irvine and J. Donald M. Gass. The incidence is more common in older types of ... Irvine-Gass syndrome, pseudophakic cystoid macular edema or postcataract CME is one of the most common causes of visual loss ... Kiernan, Daniel F.; Hariprasad, Seenu M. (1 November 2013). "Controversies in the management of Irvine-Gass syndrome". ...
Acute inhalation injury
In the acute phase of ALI, there is increased permeability of this barrier and protein rich fluid leaks out of the capillaries ... Morrison RJ, Bidani A. (2002) Acute respiratory distress syndrome epidemiology and pathophysiology. Chest Surg Clin N Am. 12: ... A recent chlorine gas leak in Pune, India, landed 20 individuals in the hospital. Though that was an accidental exposure, ... The direct toxicity to the cells leads to an increase in capillary permeability. Furthermore, when phosgene hydrolyzes it forms ...
Sepsis
Acute respiratory distress syndrome. Acute liver failure. Respiratory failure. Multiple organ dysfunction syndrome. *Neonatal ... Increased permeability of the lung vessels causes leaking of fluids into alveoli, which results in pulmonary edema and acute ... Glucose levels taken from capillary blood should be interpreted with care because such measurements may not be accurate. If a ... Multiple organ dysfunction syndrome. Other shock. Cardiogenic shock. Distributive shock. Anaphylaxis. Obstructive shock. ...
Intracranial aneurysm
Ehlers-Danlos syndrome types II and IV.. Specific genes have also had reported association with the development of intracranial ... If an aneurysm ruptures, blood leaks into the space around the brain. This is called a subarachnoid hemorrhage. Onset is ...
Acute respiratory distress syndrome
... microscopic air sacs responsible for the exchange of gases such as oxygen and carbon dioxide with capillaries in the lungs.[12] ... such that vascular leaking and escalation of inflammation are reduced.[41] ... Acute respiratory distress syndrome. Synonyms. Respiratory distress syndrome (RDS), adult respiratory distress syndrome, shock ... Acute respiratory distress syndrome. Acute liver failure. Respiratory failure. Multiple organ dysfunction syndrome. *Neonatal ...
Polycythemia
Capillary leak syndrome, another cause of hemoconcentration. ReferencesEdit. *^ "absolute polycythemia" at Dorland's Medical ... A specific type of relative polycythemia is Gaisböck syndrome. In this syndrome, primarily occurring in obese men, hypertension ... Stefanini, Mario; Urbas, John V.; Urbas, John E. (July 1978). "Gaisböck's syndrome: its hematologic, biochemical and hormonal ... a so-called myeloproliferative syndrome), or it may be a reaction to chronically low oxygen levels or, rarely, a malignancy. ...
Damp (structural)
Leaks most commonly occur on flat-roofed buildings.[2]:328 Certain building materials and mechanisms can be used to prevent ... the moisture will climb up the walls in obedience to the law of capillary attraction. The way to prevent this is to insert ... causing rot or mould health issues and may eventually lead to sick building syndrome. Plaster and paint deteriorate and ... According to Jurin's law the maximum height of rise is inversely proportional to the capillary radius.[39] Taking a typical ...
Մասնակից:ArmArtificial Intelligence/Ավազարկղ - Վիքիպեդիա՝ ազատ հանրագիտարան
Acute respiratory distress syndrome, sepsis, and cognitive decline: a review and case study»։ Southern Medical Journal 102 (11 ... Increased permeability of the lung vessels causes leaking of fluids into alveoli, which results in pulmonary edema and acute ... Glucose levels taken from capillary blood should be interpreted with care because such measurements may not be accurate. If a ... In 2016 a new consensus was reached to replace screening by systemic inflammatory response syndrome (SIRS) with qSOFA.[1] ...
Bleeding
The patient's blood pressure drops, the heart rate increases, peripheral hypoperfusion (shock) with diminished capillary refill ... where blood leaks from damaged blood vessels inside the body, or externally, either through a natural opening such as the mouth ... a potentially catastrophic and not so rare complication among lean patients with polycystic ovary syndrome". Fertil. Steril. 93 ... this is a potentially catastrophic and not so rare complication among lean patients with polycystic ovary syndrome undergoing ...
Pancreatic cancer
... has been associated with the following other rare hereditary syndromes: Peutz-Jeghers syndrome due to ... an extensive but capillary-like duct-system fanning out) within the pancreas.[22] This cancer originates in the ducts that ... it will very often leak later on. In 1907-08, after some more unsuccessful operations by other surgeons, experimental ... PanNETs have been associated with multiple endocrine neoplasia type 1 (MEN1) and von Hippel Lindau syndromes.[2][3][4]. * ...
Lung
The major function of the lungs is gas exchange between the lungs and the blood.[44] The alveolar and pulmonary capillary gases ... Ayed, A.K. (2004). "Resection of the right middle lobe and lingula in children for middle lobe/lingula syndrome". Chest. 125 (1 ... to burst and leak high pressure air into the pleural space. ... The pulmonary capillaries surround the parabronchi in the ... Only after the maturation of the capillary network can the lung enter a normal phase of growth. Following the early growth in ...
Pulmonary contusion
... torn capillaries leak fluid into the tissues around them. The membrane between alveoli and capillaries is torn; damage to this ... Other severe complications, including infections and acute respiratory distress syndrome (ARDS) occur in up to half of cases. ... capillary-alveolar membrane and small blood vessels causes blood and fluids to leak into the alveoli and the interstitial space ... As a result of damage to capillaries, blood and other fluids accumulate in the lung tissue. The excess fluid interferes with ...
Sepsis
In 2016 a new consensus was reached to replace screening by systemic inflammatory response syndrome (SIRS) with qSOFA.[4] ... Increased permeability of the lung vessels causes leaking of fluids into alveoli, which results in pulmonary edema and acute ... Glucose levels taken from capillary blood should be interpreted with care because such measurements may not be accurate. If a ... Lungs: acute respiratory distress syndrome (ARDS) (PaO2/FiO2 ratio, 300), different ratio in pediatric acute respiratory ...
Air conditioning
Though his prototype leaked and performed irregularly, Gorrie was granted a patent in 1851 for his ice-making machine. Though ... Capillary expansion valve connection to evaporator inlet. Notice frost formation.. Cooling in traditional AC systems is ... Although these gasses can be recycled when air conditioning units are disposed of, uncontrolled dumping and leaking can release ... as long as it does not leak. Although R22 is now banned, units that use the refrigerant can still be serviced and maintained. ...
Venous ulcer
... lower the amount of fluid leaking from capillaries and therefore prevent swelling, and prevent clotting by decreasing ... Additional causes include neutrophilic dermatoses such as pyoderma gangrenosum or Sweet syndrome; vasculitic processes such as ... Venous hypertension may also stretch veins and allow blood proteins to leak into the extravascular space, isolating ... or myelodysplastic syndrome; neuropathy (e.g., diabetic peripheral neuropathy); or atypical infections such as nocardiosis, ...
Water retention (medicine)
When the capillary walls are too permeable, protein can leak out of the blood and settle in the tissue spaces. It will then act ... Kidney disease often starts with inflammation, for instance in the case of diseases such as nephrotic syndrome or lupus. Once ... the pressure can force too much fluid out of the leg capillaries into the tissue spaces. The capillaries may break, leaving ... The role of capillary hyperpermeability and its correction by Ginkgo biloba extract". La Presse Médicale. 15 (31): 1550-1553.. ...
Subarachnoid hemorrhage
... where a process of increased pressure within the pulmonary circulation causes leaking of fluid from the pulmonary capillaries ... This is known as Terson syndrome (occurring in 3-13 percent of cases) and is more common in more severe SAH.[9] ... This type of headache is referred to as "sentinel headache", because it is presumed to result from a small leak (a "warning ... leak") from an aneurysm. A sentinel headache still warrants investigations with CT scan and lumbar puncture, as further ...
Glycolysis
In addition, it blocks the glucose from leaking out - the cell lacks transporters for G6P, and free diffusion out of the cell ... limited capillary support often results in hypoxia (decreased O2 supply) within the tumor cells. Thus, these cells rely on ... "Topical Review: A reappraisal of the blood glucose homeostat which comprehensively explains the type 2 diabetes-syndrome X ...
Nephrotic syndrome
It is formed of capillaries with small pores that allow small molecules to pass through that have a molecular weight of less ... Membranous glomerulonephritis (MGN): The inflammation of the glomerular membrane causes increased leaking in the kidney. It is ... Cushing's syndrome. Treatment[edit]. The treatment of nephrotic syndrome can be symptomatic or can directly address the ... "Nephrotic Syndrome in Adults". National Institute of Diabetes and Digestive and Kidney Diseases. February 2014. Retrieved 9 ...
தண்டுவட மரப்பு நோய் - தமிழ் விக்கிப்பீடியா
17.0 17.1 Miller D, Barkhof F, Montalban X, Thompson A, Filippi M (May 2005). "Clinically isolated syndromes suggestive of ... Leech S, Kirk J, Plumb J, McQuaid S (2007). "Persistent endothelial abnormalities and blood-brain barrier leak in primary and ... மூளை இரத்த தடுப்பு (blood-brain barrier) ஓர் இரத்த நுண்குழாய் (capillary) அமைப்பாகும், இது டி செல்கள் நரம்பு மண்டலத்தை ... Aphasia and parietal syndrome as the presenting symptoms of a demyelinating disease with pseudotumoral lesions"] (in Spanish; ...
Aneurysm
602 Connective tissue disorders such as Loeys-Dietz syndrome, Marfan syndrome, and certain forms of Ehlers-Danlos syndrome are ... A false aneurysm, or pseudoaneurysm, is a collection of blood leaking completely out of an artery or vein but confined next to ... Capillaries, specifically capillary aneurysms.. *The Large vessels such as external and internal jugular veins[12] ... Vascular Ehlers-Danlos Syndrome. 1999 Sep 2 [Updated 2019 Feb 21]. In: Adam MP, Ardinger HH, Pagon RA, et al., editors. ...
Dengue fever
Fluid from the bloodstream leaks through the wall of small blood vessels into body cavities due to capillary permeability. As a ... Ranjit S, Kissoon N (January 2011). "Dengue hemorrhagic fever and shock syndromes". Pediatric Critical Care Medicine. 12 (1): ... The recovery phase occurs next, with resorption of the leaked fluid into the bloodstream.[22] This usually lasts two to three ... Severe disease is marked by the problems of capillary permeability (an allowance of fluid and protein normally contained within ...
Lung
The major function of the lungs is gas exchange between the lungs and the blood.[63] The alveolar and pulmonary capillary gases ... and infant respiratory distress syndrome caused by a deficiency in lung surfactant. An azygos lobe is a congenital anatomical ... to burst and leak high pressure air into the pleural space. ... The pulmonary capillaries surround the parabronchi in the ... The smaller bronchi have a single layer of lymph capillaries, and they are absent in the alveoli.[14] Each lung is surrounded ...
Macular edema
Diabetic macular edema (DME) is similarly caused by leaking macular capillaries. DME is the most common cause of visual loss in ... pseudophakia' means 'replacement lens') also known as Irvine-Gass syndrome The surgery involved sometimes irritates the retina ... and other parts of the eye) causing the capillaries in the retina to dilate and leak fluid into the retina. Less common today ... Blockage of a vein in the retina can cause engorgement of the other retinal veins causing them to leak fluid under or into the ...
Mesenteric ischemia
Finally, a shock phase can develop as fluids start to leak through the damaged colon lining. This can result in shock and ... The first device approved by the U.S. FDA (in 2004) used visible light spectroscopy to analyze capillary oxygen levels. Use ... Blind loop syndrome. *Small bowel bacterial overgrowth syndrome. *Whipple's. *Short bowel syndrome ...
Cerebrospinal fluid
CSF leakEdit. CSF can leak from the dura as a result of different causes such as physical trauma or a lumbar puncture, or from ... Firstly, a filtered form of plasma moves from fenestrated capillaries in the choroid plexus into an interstitial space,[1] with ... paraneoplastic syndromes, systemic lupus erythematosus, neurosarcoidosis, cerebral angiitis;[1] and specific antibodies such as ... If a leak is identified, a beta-2 transferrin test of the leaking fluid, when positive, is highly specific and sensitive for ...
Dengue fever - Simple English Wikipedia, the free encyclopedia
This is called dengue shock syndrome. Plasma also carries platelets, which help the blood clot (they help stop bleeding). If a ... During this stage, plasma (the liquid part of blood) leaks out of the body's small blood vessels. The plasma can build up in ... Petechiae (small red spots on the skin). These are caused by capillaries (which carry blood) breaking. This makes the blood ... However, a small number of people get dengue hemorrhagic fever or dengue shock syndrome. These are medical emergencies and can ...
Idiopathic systemic capillary leak syndrome
... (ISCLS) is a rare disorder characterized by episodes of severe hypotension, ... Systemic capillary leak syndrome. Intern Med 2002; 41:953.. *Barnadas MA, Cisteró A, Sitjas D, et al. Systemic capillary leak ... Systemic capillary leak syndrome causes a compartment syndrome of both lower legs and a forearm. A case report with a review of ... Systemic capillary leak syndrome associated with compartment syndrome and rhabdomyolysis. Anaesth Intensive Care 2006; 34:388. ...
Capillary leak syndrome in dengue fever.
Capillary leak syndrome (CLS) has been described in dengue fever but its exact features have not been clearly defined. We ... Capillary leak syndrome in dengue fever. Dengue Bulletin. 2011 Dec; 35: 65-70. ... 2011). Capillary leak syndrome in dengue fever.. WHO Regional Office for South-East Asia.. https://apps.who.int/iris/handle/ ...
Systemic capillary leak syndrome - Mayo Clinic
Systemic capillary leak syndrome is a rare disorder characterized by recurrent flares of massive leakage of plasma and other ... The systemic capillary leak syndrome: A case series of 28 patients from a European registry. Annals of Internal Medicine 2011; ... Systemic capillary leak syndrome may be triggered by an upper respiratory tract infection. Signs and symptoms of systemic ... Idiopathic systemic capillary leak syndrome (Clarksons disease): The Mayo Clinic Experience. Mayo Clinic Proceedings. 2010;85: ...
Systemic capillary leak syndrome definition | Drugs.com
The Current Opinions of Capillary Leak Syndrome
Capillary Leak Syndrome (CLS) in patients with severe course of disease is more and more common, and the clinical ... Anorexia in a Patient With Atypical Hemolytic Uremic Syndrome and Systemic Capillary Leak Syndrome: A Case Report ... "The Current Opinions of Capillary Leak Syndrome" written by Jun Su, Ying Zhang, Wei Hu, published by Open Journal of Clinical ... Fatal Primary Capillary Leak Syndrome in a Late Preterm Newborn. The Indian Journal of Pediatrics, 2016. DOI:10.1007/s12098-016 ...
CiNii 論文 -
Systemic Capillary Leak Syndrome
Systemic capillary leak syndrome with monoclonal IgG and complement alterations. A case report on an episodic syndrome LOFDAHL ... Systemic Capillary Leak Syndrome * * Kawabe Shotetsu KAWABE Shotetsu * the Department of Internal Medicine, Nagaoka Red Cross ... Systemic capillary leak syndrome and monoclonal IgG gammopathy; studies in a sixth patient and a review of the literature ... Capillary leak syndrome associated with elevated IL-2 serum levels after allogeneic bone marrow transplantation FUNKE I. ...
Systemic Capillary Leak Syndrome
... Ruri CHIHARA1), Hidetomo NAKAMOTO1), Hiroshi ARIMA1), Kenshi MORIWAKI1), Yoshihiko KANNO1), ... Systemic capillary leak syndrome (SCLS) is characterized by recurrent hypovolemic shock attributable to increased systemic ... capillary leakage. A 46-year-old man was admitted to our hospital because of recurrent episodes of generalized edema with ...
The Systemic Capillary Leak Syndrome | Annals of Internal Medicine | American College of Physicians
The systemic capillary leak syndrome (SCLS) can be a dramatic, perplexing, and terrifying disease to treat, particularly in its ... The Systemic Capillary Leak Syndrome Bert A. Govig, MD; Sepehr Javaheri, MD ... Govig BA, Javaheri S. The Systemic Capillary Leak Syndrome. Ann Intern Med. 2010;153:764. doi: 10.7326/0003-4819-153-11- ... We thank Druey and Greipp for raising awareness of this rare syndrome and would like to complement their excellent review (1) ...
The Systemic Capillary Leak Syndrome | Annals of Internal Medicine | American College of Physicians
The Systemic Capillary Leak Syndrome. Ann Intern Med. 2010;153:764. doi: 10.7326/0003-4819-153-11-201012070-00015 ... The very interesting review on the systemic capillary leakage of circulating macromolecules (1) suggests capillary dysfunction ... One wonders whether similar changes also occur in the generalized leakage syndrome. ... Narrative Review: The Systemic Capillary Leak Syndrome The Systemic Capillary Leak Syndrome ...
AstraZeneca vaccine linked to second blood condition after five cases of capillary leak syndrome reported
What is capillary leak syndrome?. Capillary leak syndrome happens when blood leaks from tiny vessels into muscles and body ... Five people suffered capillary leak syndrome after getting a dose of the AstraZeneca jab, the EUs vaccines watchdog saysCredit ... Data suggests the UKs regulator, the MHRA, had spotted three cases of capillary leak syndrome out of 20million people given ... EU vaccines watchdog the European Medicines Authority (EMA) has announced there have been five cases of capillary leak syndrome ...
Fatal Exacerbations of Systemic Capillary Leak Syndrome Complicating Coronavirus Disease - Volume 27, Number 10-October 2021 -...
Lacout C, Rogez J, Orvain C, Nicot C, Rony L, Julien H, et al. A new diagnosis of systemic capillary leak syndrome in a patient ... Xie Z, Chan E, Yin Y, Ghosh CC, Wisch L, Nelson C, et al. Inflammatory markers of the systemic capillary leak syndrome ( ... Matheny M, Maleque N, Channell N, Eisch AR, Auld SC, Banerji A, et al. Severe exacerbations of systemic capillary leak syndrome ... Kapoor P, Greipp PT, Schaefer EW, Mandrekar SJ, Kamal AH, Gonzalez-Paz NC, et al. Idiopathic systemic capillary leak syndrome ( ...
Table 3 - Fatal Exacerbations of Systemic Capillary Leak Syndrome Complicating Coronavirus Disease - Volume 27, Number 10...
A Remarkable Coexistence of Systemic Capillary Leak Syndrome and Diabetes in an 11-Year-Old Boy: A Case Report and Review of...
There was no compartment syndrome, rhabdomyolysis, or pulmonary edema in the recovery period. However, respiratory virus panel ... is a rare disease characterized by unexplained reversible capillary hyperpermeability followed by hypoperfusion, ... Systemic capillary leak syndrome (ISCLS) is a rare disease characterized by unexplained reversible capillary hyperpermeability ... Idiopathic systemic capillary leak syndrome (ISCLS) is a rare disease characterized by unexplained reversible capillary ...
Capillary protein leak syndrome appears to explain fluid retention in cancer patients who receive docetaxel treatment.
The aim of our study was to elucidate whether the fluid retention syndrome induced by docetaxel is caused by capillary protein ... Capillary Leak Syndrome / chemically induced*, complications. Capillary Permeability. Carcinoma, Non-Small-Cell Lung / drug ... PURPOSE: The aim of our study was to elucidate whether the fluid retention syndrome induced by docetaxel is caused by capillary ... These observations support the theory of a capillary protein leakage.. CONCLUSION: Docetaxel appears to induce an initial ...
Systemic Capillary Leak Syndrome Associated with Multiple Myeloma of IgG κType
... Eiji HIRAOKA1), Yumi MATSUSHIMA1), Yoko INOMOTO ... A case of systemic capillary leak syndrome in a 67-year-old woman is reported. The patient suddenly presented with severe edema ... Although most of the cases of systemic capillary leak syndrome reported previously were accompanied by monoclonal gammopathy, ... this appears to be the first case in which capillary leak syndrome developed in a patient with multiple myeloma.. (Internal ...
Capillary Leak Syndrome | definition of Capillary Leak Syndrome by Medical dictionary
What is Capillary Leak Syndrome? Meaning of Capillary Leak Syndrome medical term. What does Capillary Leak Syndrome mean? ... Looking for online definition of Capillary Leak Syndrome in the Medical Dictionary? Capillary Leak Syndrome explanation free. ... Anterior tibial compartment syndrome secondary to systemic capillary leak syndrome.. Systemic capillary leak syndrome ... Systemic capillary leak syndrome presenting as recurrent shock.. Systemic capillary leak syndrome associated with pleural ...
EMA Advises Against Using Janssen's COVID-19 Vaccine in People with Capillary Leak Syndrome
EMAs PRAC has advised against the use of Janssens COVID-19 vaccine in people who have a history of capillary leak syndrome. ... Capillary leak syndrome is a very rare and serious condition and as a result of PRACs review, it has been recommended that the ... Signs and symptoms of capillary leak syndrome include rapid swelling of the arms and legs or sudden weight gain, which is a ... This recommendation has been based on a review of three cases where capillary leak syndrome occurred in people within two days ...
Idiopathic systemic capillary leak syndrome presenting as septic shock: A case report
We report a case of idiopathic systemic capillary leak syndrome presenting as septic s ... Idiopathic capillary leak syndrome (Clarksons Disease) is a rare angiopathy with a heterogenous phenotype that may present as ... Idiopathic systemic capillary leak syndrome presenting as septic shock: A case report ... Background:Idiopathic capillary leak syndrome (Clarksons Disease) is a rare angiopathy with a heterogenous phenotype that may ...
Systemic capillary leak syndrome | Genetic and Rare Diseases Information Center (GARD) - an NCATS Program
... www.uptodate.com/contents/idiopathic-systemic-capillary-leak-syndrome. *Amoura Z. Systemic capillary leak syndrome. Orphanet. ... There is currently no cure for systemic capillary leak syndrome. (SCLS). Treatment for SCLS during an episode is mainly ... Intravenous Immunoglobulins Improve Survival in Monoclonal Gammopathy-Associated Systemic Capillary-Leak Syndrome. Am J Med. ... Is there a full and final cure for systemic capillary leak syndrome? ...
Interleukin-11-induced capillary leak syndrome in primary hepatic carcinoma patients with thrombocytopenia. | CureHunter
Interleukin-11-induced capillary leak syndrome in primary hepatic carcinoma patients with thrombocytopenia. - Wang Kai-Feng, ... Capillary leak syndrome (CLS) is a rare condition characterized by recurrent episodes of generalized edema and severe ... Interleukin-11-induced capillary leak syndrome in primary hepatic carcinoma patients with thrombocytopenia.. Abstract. ...
Systemic capillary leak syndrome | Genetic and Rare Diseases Information Center (GARD) - an NCATS Program
... resources and questions answered by our Genetic and Rare Diseases Information Specialists for Systemic capillary leak syndrome ... SCLS; Clarkson disease; Capillary leak syndrome; SCLS; Clarkson disease; Capillary leak syndrome; Capillary leak syndrome with ... www.uptodate.com/contents/idiopathic-systemic-capillary-leak-syndrome. *Druey KM, Parikh SM. Idiopathic systemic capillary leak ... Systemic capillary leak syndrome. (SCLS) is a condition in which fluid and proteins. leak out of tiny blood vessels, into ...
Systemic capillary leak syndrome revealing a diffuse large B-cell lymphoma
Systemic capillary leak syndrome,, Aged, Capillary Leak Syndrome, Female, Humans, Lymphoma, Large B-Cell, Diffuse, 1101 Medical ... suggestive of systemic capillary leak syndrome (SCLS). Further investigations led to a diagnosis of diffuse large B-cell ... Systemic capillary leak syndrome, Non-Hodgkin lymphoma, PATIENT, DISEASE, SERUM, SHOCK, ...
Pneumotox » Drug » Chemotherapy, antineoplastic » X.c - Capillary leak syndrome (CLS)
Idiopathic systemic capillary leak syndrome (Clarkson's disease) - Minerva Medica 1999 October;90(10):391-6 - Minerva Medica -...
Antiphospholipids Syndrome Complicated by a Systemic Capillary Leak-Like Syndrome Treated With Steroids and Intravenous...
Antiphospholipids Syndrome Complicated by a Systemic Capillary Leak-Like Syndrome Treated With Steroids and Intravenous ... This report describes the onset of systemic capillary leak (SCL)-like syndrome in a 30-year-old woman with antiphospholipids ... Because fever and raised inflammation parameters are not observed in idiopathic capillary leak syndrome (SCLS; Clarkson disease ... The data indicate that SCL-like syndrome can be considered a novel clinical syndrome, which can complicate APS. ...
Summary Safety Review - YONDELIS (trabectedin) - Assessing the Potential Risk of Fluid Leakage from Small Blood Vessels ...
Some of these cancer drugs are labelled for capillary leak syndrome in their product information. Capillary leak syndrome is ... Capillary leak syndrome is a rare but potentially life-threatening condition which involves the leakage of fluid from the small ... Patients with capillary leak syndrome require timely treatment to replace fluid in the body with saline based fluids through ... Health Canada carried out a safety review to look into the potential risk of capillary leak syndrome with the use of Yondelis. ...
Bilateral simultaneous non-arteritic ischaemic optic neuropathy: a rare complication of idiopathic systemic capillary leak...
Filgrastim and pegfilgrastim: risk of capillary leak syndrome | Document Summary - Evidence Search - Search Engine for Evidence...
Filgrastim and pegfilgrastim: risk of capillary leak syndrome Source:. GOV UK. Publisher:. Medicines and Healthcare products ... Capillary leak syndrome (CLS) has been reported in recipients of filgrastim, including patients undergoing chemotherapy and a ... Prescribers should monitor patients and healthy donors for signs and symptoms of capillary leak syndrome (CLS), and should give ...
Systemic capillary leak syndrome after granulocyte colony-stimulating factor (G-CSF). - Semantic Scholar
... which result in the systemic inflammatory response syndrome (SIRS). We present two cases in which both patients suffered with ... Capillary leak syndrome (CLS) commonly occurs in the intensive care setting. CLS is seen in conditions such as septic shock or ... Systemic capillary leak syndrome associated with multiple myeloma of IgG kappa type.. *E Hiraoka, Y Matsushima, +6 authors T ... Possible mediators for systemic capillary leak syndrome.. *Yoshiro Nagao, Hiromasa Harada, Hiromi Yamanaka, Ko Fukuda ...
Capillary leak syndrome - Wikipedia
Systemic capillary leak syndrome (SCLS), also called Clarksons disease, or primary capillary leak syndrome, is a rare, grave ... can also cause capillary leaks. These conditions and factors are sources of secondary capillary leak syndrome. ... Capillary leak syndrome is characterized by the escape of blood plasma through capillary walls, from the blood circulatory ... engraftment syndrome, hemophagocytic lymphohistiocytosis, the ovarian hyperstimulation syndrome, viral hemorrhagic fevers, and ...
SCLSFive cases of capillary leak synClarksonBlood vesselsIdiopathic systemicPatient with systemic capillarAssociated with systemic capillarRisk of capillary leak synPeople with Capillary Leak SynIncreased capillary permeabilityPermeabilityFatal systemic capillarMonoclonalVascularSymptomsHyperpermeabilityRecurrentPulmonaryEndothelialSystemic capillary leakageAcute respiratPatientsEndotheliumEdemaARDSDengue feverDiseaseVaccineClinicalShockAttacksSepsisPoresTissuesAstraZenecaCasesRhabdomyolysisRareLeakage syndromePediatricSevere acute respiSecondary
SCLS22
- Systemic capillary leak syndrome (SCLS), also called Clarkson's disease, or primary capillary leak syndrome, is a rare, grave and episodic medical condition observed largely in otherwise healthy individuals mostly in middle age. (wikipedia.org)
- We diagnosed the patient as having typical systemic capillary leak syndrome (SCLS) and she improved gradually after infusion of albumin-containing fluid. (nii.ac.jp)
- SCLS is a very rare condition caused by unexplained episodic capillary hyperpermeability. (nii.ac.jp)
- Systemic capillary leak syndrome (SCLS) is characterized by recurrent hypovolemic shock attributable to increased systemic capillary leakage. (go.jp)
- The systemic capillary leak syndrome (SCLS) can be a dramatic, perplexing, and terrifying disease to treat, particularly in its initial presentation. (annals.org)
- We report 2 fatal exacerbations of systemic capillary leak syndrome (SCLS), also known as Clarkson disease, associated with coronavirus disease (COVID-19) in the United States. (cdc.gov)
- This clinical picture suggests that these patients succumbed to complications of SCLS induced by infection with severe acute respiratory syndrome coronavirus 2. (cdc.gov)
- Systemic capillary leak syndrome (SCLS), also known as Clarkson disease, is a rare disease of unknown etiology that most commonly develops in adults 50-70 years of age ( 1 ). (cdc.gov)
- Severe SCLS flares commonly result in multisystem organ failure and peripheral compartment syndromes ( 2 ). (cdc.gov)
- There is currently no cure for systemic capillary leak syndrome (SCLS). (nih.gov)
- Systemic capillary leak syndrome (SCLS) is a condition in which fluid and proteins leak out of tiny blood vessels, into surrounding tissues . (nih.gov)
- We report on a 75-year-old woman who presented with recurrent episodes of hypotension, anasarca, renal failure, hypoalbuminaemia without proteinuria, suggestive of systemic capillary leak syndrome (SCLS). (kuleuven.be)
- The prompt treatment with steroids and IVIG likely prevented the life-threatening shock syndrome that can occur in SCLS, with acute hypotensive attacks, and severe limbs edema requiring fasciotomy. (ovid.com)
- We report a case of bilateral symmetrical superior visual field defects in a 72-year-old man first reported during the recovery from systemic capillary leak syndrome (SCLS). (bmj.com)
- Idiopathic systemic capillary leak syndrome (SCLS): case report and systematic review of cases reported in the last 16 years. (dbcls.jp)
- The Systemic Capillary Leak Syndrome (SCLS) is an extremely rare, orphan disease that resembles, and is frequently erroneously diagnosed as, systemic anaphylaxis. (cdc.gov)
- Often, compartment syndrome can lead to rhabdomyolysis as a serious complication of SCLS. (mysteria.cz)
- Systemic capillary leak syndrome (SCLS) is due to recurrent episodes of generalised increased capillary permeability. (mysteria.cz)
- Systemic Capillary Leak Syndrome (SCLS) is an exceedingly rare, life- and limb-threatening disorder characterized by acute and severe recurrent attacks featuring a rapid fall in blood pressure due to the temporary leak of plasma out of the blood circulatory system. (rareshare.org)
- Systemic Capillary Leak Syndrome (SCLS) is a rare disorder characterized by increased capillary hyperpermeability leading to hypovolemic shock due to a markedly increased shift of fluid and protein from the intravascular to the interstitial space. (biomedcentral.com)
- Here we present a patient who suffered from SCLS with hypovolemic shock and compartment syndrome of both lower legs and thighs. (biomedcentral.com)
- Our research program includes studies aimed at mechanistic dissection of fungal associated-asthma and exploration of the pathogenesis of the rare vascular disorder resembling systemic anaphylaxis, a condition known as systemic capillary leak syndrome (SCLS, Clarkson disease). (nih.gov)
Five cases of capillary leak syn3
- EU vaccines watchdog the European Medicines Authority (EMA) has announced there have been five cases of capillary leak syndrome in patients given a dose on the continent. (thescottishsun.co.uk)
- The European Medicines Authority (EMA) said five cases of capillary leak syndrome had been reported in vaccinated patients on the continent. (loire-net.tv)
- An EMA press release issued today notes that five cases of capillary leak syndrome, characterized by leakage of fluid from blood vessels causing tissue swelling and a drop in blood pressure in individuals receiving the AstraZeneca vaccine, were reported in the EudraVigilance database. (themontserratreporter.com)
Clarkson12
- ISCLS was first described by Clarkson in 1960 and is variably referred to as Clarkson's disease or syndrome [ 1 ]. (uptodate.com)
- Vascular endothelial hyperpermeability induces the clinical symptoms of Clarkson disease (the systemic capillary leak syndrome). (mayoclinic.org)
- Production of 5-lipoxygenase pathway metabolites by peripherical leucocytes in capillary leak syndrome (Clarkson disease). (thefreedictionary.com)
- Clarkson disease), a diagnosis of SCL-like syndrome was made. (ovid.com)
- Neutrophil activation in systemic capillary leak syndrome (Clarkson disease). (dbcls.jp)
- A Systemic Capillary Leak Syndrome (Clarkson Syndrome) in a Patient with Chronic Lymphocytic Leukemia: A Case Report in an Out-of-Hospital Setting. (dbcls.jp)
- Clinical and pathological findings of a fatal systemic capillary leak syndrome (Clarkson disease): a case report. (dbcls.jp)
- Spinal Anesthesia in a Patient With a History of Systemic Capillary Leak Syndrome (Clarkson Disease). (dbcls.jp)
- Inflammatory Markers of the Systemic Capillary Leak Syndrome (Clarkson Disease). (dbcls.jp)
- Genome-wide SNP analysis of the Systemic Capillary Leak Syndrome (Clarkson disease). (cdc.gov)
- A natural mouse model reveals genetic determinants of Systemic Capillary Leak Syndrome (Clarkson disease). (nih.gov)
- Adrenomedullin surges are linked to acute episodes of the systemic capillary leak syndrome (Clarkson Disease). (nih.gov)
Blood vessels9
- Systemic capillary leak syndrome is a rare disorder characterized by recurrent flares of massive leakage of plasma and other blood components from blood vessels into neighboring body cavities and muscles. (mayoclinic.org)
- Signs and symptoms of capillary leak syndrome include rapid swelling of the arms and legs or sudden weight gain, which is a result of the fluid leakage from small blood vessels. (pharmtech.com)
- This safety review was triggered by international reports of fluid leakage from small blood vessels (a rare but serious condition called capillary leak syndrome) in patients who used Yondelis. (canada.ca)
- Capillary leak syndrome is a rare but potentially life-threatening condition which involves the leakage of fluid from the small blood vessels into various parts of the body. (canada.ca)
- Capillaries are very tiny blood vessels - so small that a single red blood cell can barely fit through them. (healthline.com)
- Capillaries connect the arterial system - which includes the blood vessels that carry blood away from your heart - to your venous system . (healthline.com)
- Their single-layer endothelium composition, which varies among the different types of capillaries, and surrounding basement membrane makes capillaries a bit "leakier" than other types of blood vessels. (healthline.com)
- Capillary leak syndrome is a very rare, serious condition that causes fluid to leak from small blood vessels (capillaries), resulting in swelling of the arms and legs, sudden weight gain, low blood pressure, thickening of the blood, and low blood pressure. (technicalgaurav.com)
- Lumoxiti can cause fluid to leak from small blood vessels into your body's tissues. (medicineshoppe.com)
Idiopathic systemic15
- Idiopathic systemic capillary leak syndrome (ISCLS) is a rare disorder characterized by episodes of severe hypotension, hypoalbuminemia, and hemoconcentration [ 1,2 ]. (uptodate.com)
- Approximately 150 cases of idiopathic systemic capillary leak syndrome (ISCLS) have been reported worldwide [ 3,4 ]. (uptodate.com)
- The cause(s) of idiopathic systemic capillary leak syndrome (ISCLS) is not known, although there is an associated monoclonal gammopathy in many patients. (uptodate.com)
- Idiopathic systemic capillary leak syndrome (Clarkson's disease): The Mayo Clinic Experience. (mayoclinic.org)
- Following further deterioration, Idiopathic systemic capillary leak syndrome was considered and intravenous immunoglobulin administered, resulting in rapid improvement in the patient's clinical status. (ovid.com)
- Idiopathic systemic capillary leak syndrome is a rare and potentially life-threatening angiopathy that may present as, and should be considered in, refractory distributive shock. (ovid.com)
- Idiopathic systemic capillary leak syndrome (Clarkson's disease) is characterized by recurring attacks or increased capillary permeability, resulting in severe hypovolemic shock due to plasma extravasation from the intravascular compartment. (minervamedica.it)
- Idiopathic systemic capillary leak syndrome: novel therapy for acute attacks. (semanticscholar.org)
- Idiopathic Systemic Capillary Leak Syndrome (ISCLS) is a fatal disorder characterised by recurrent episodes of hypotension, hypoalbuminemia and haemoconcentration. (jcdr.net)
- Idiopathic Systemic Capillary Leak Syndrome (ISCLS) is a rare condition characterized by hypotension, edema, and fluid extravasation with potentially life threatening complications including multi-organ failure 1 . (gwu.edu)
- Recognition and management of idiopathic systemic capillary leak syndrome: an evidence-based review. (dbcls.jp)
- High-dose intravenous immunoglobulins: a promising therapeutic approach for idiopathic systemic capillary leak syndrome. (dbcls.jp)
- Idiopathic systemic capillary leak syndrome: a case report with cardiac involvement]. (dbcls.jp)
- Idiopathic systemic capillary leak syndrome: cutaneous involvement can be misleading. (dbcls.jp)
- PPDs include primary angioedema, idiopathic systemic capillary leak syndrome and some rare forms of localized retroperitoneal-mediastinal edema. (frontiersin.org)
Patient with systemic capillar2
- Multiglandular hormone deficiency in a patient with systemic capillary leak syndrome. (dbcls.jp)
- I demonstrated the importance of the regulation of the small GTPase RhoB in a pediatric patient with systemic capillary leak syndrome caused by a single gene mutation in a GAP with previously unknown function, p190BRhoGAP. (yale.edu)
Associated with systemic capillar2
Risk of capillary leak syn3
- Health Canada s safety review concluded that there is a potential risk of capillary leak syndrome with the use of Yondelis. (canada.ca)
- Health Canada carried out a safety review to look into the potential risk of capillary leak syndrome with the use of Yondelis. (canada.ca)
- Health Canada is recommending updates to the Canadian product information to include the potential risk of capillary leak syndrome with the use of Yondelis. (canada.ca)
People with Capillary Leak Syn1
- Earlier this month, the European Union's drug regulator said it had reviewed the cases of six people with capillary leak syndrome after receiving one shot of the AstraZeneca vaccine out of 78 million doses of AstraZeneca and Covishield vaccines administered in Europe and the United Kingdom. (technicalgaurav.com)
Increased capillary permeability2
Permeability2
- These investigations occur in culture models of capillary endothelium and focus on small GTPases and their regulators, GAPs and GEFs, regulate permeability of EC monolayers and re-organization of tight junction molecules. (yale.edu)
- Sera From Children After Cardiopulmonary Bypass Reduces Permeability of Capillary Endothelial Cell Barriers. (yale.edu)
Fatal systemic capillar2
Monoclonal5
- Pharmaceuticals, including the chemotherapy medications gemcitabine and tagraxofusp, as well as certain interleukins and monoclonal antibodies, can also cause capillary leaks. (wikipedia.org)
- Systemic capillary leak syndrome with monoclonal IgG and complement alterations. (nii.ac.jp)
- Although most of the cases of systemic capillary leak syndrome reported previously were accompanied by monoclonal gammopathy, this appears to be the first case in which capillary leak syndrome developed in a patient with multiple myeloma. (go.jp)
- Systemic capillary leak syndrome and monoclonal IgG gammapathy: studies in a sixth patient and review of the literature. (thefreedictionary.com)
- Intravenous Immunoglobulins Improve Survival in Monoclonal Gammopathy-Associated Systemic Capillary-Leak Syndrome. (nih.gov)
Vascular8
- Mechanisms of capillary leakage - The vascular endothelium is a semi-permeable barrier that controls the passage of fluid and macromolecules between the intravascular and interstitial spaces. (uptodate.com)
- A condition characterized by recurring episodes of fluid leaking from capillaries into extra-vascular compartments causing hematocrit to rise precipitously. (opentoxipedia.org)
- A rare, but potentially serious disease in which fluids within the vascular system (veins and capillaries) leaks into the tissue outside the bloodstream. (chemocare.com)
- Vascular leak is a central feature in the pathogenesis of systemic sclerosis. (biomedsearch.com)
- The universal morphologically abnormal endothelial cells and interstitial edema in all patients with SSc biopsied suggests that SSc may be intrinsically a disease of the endothelium characterized by vascular leak. (biomedsearch.com)
- Compromised vascular integrity is associated with capillary leakage in sepsis, but effective therapies stabilizing the vasculature are lacking. (pnas.org)
- These results indicate that β1-integrin actively promotes vascular leakage and that targeting β1-integrin signaling could be a novel means of achieving vascular stabilization in pathological vascular leak. (pnas.org)
- Another focus of my lab is investigating consequences of vascular dyfunction in critically ill children, namely pulmonary capillary dysfunction in pediatric acute lung injury. (yale.edu)
Symptoms11
- The symptoms result from a sudden and unexplained increase in the leakiness of small blood vessel (capillary) walls. (mayoclinic.org)
- Attacks of ISCLS tend to demonstrate three phases: prodromal symptoms, capillary leak, and recovery [ 5 ]. (hindawi.com)
- Systemic capillary leak syndrome is diagnosed based on physical examination, laboratory tests, and recurrence of symptoms. (nih.gov)
- The diagnosis is supported by ruling out other illnesses with similar symptoms, including secondary capillary leak syndrome or abnormally low levels of protein in the blood (hypoproteinemia). (nih.gov)
- Patients with capillary leak syndrome require timely treatment to replace fluid in the body with saline based fluids through the veins, and manage their symptoms in order to improve their condition. (canada.ca)
- Prescribers should monitor patients and healthy donors for signs and symptoms of capillary leak syndrome (CLS), and should give standard symptomatic treatment immediately if symptoms occur. (evidence.nhs.uk)
- While capillaries are very small, anything unusual in their functioning can cause visible symptoms or even potentially serious medical conditions. (healthline.com)
- Myelodysplastic Syndrome (MDS) and Acute Myeloid Leukemia (AML): Monitor patients with breast and lung cancer using Fulphila in conjunction with chemotherapy and/or radiotherapy for signs and symptoms of MDS/AML. (nih.gov)
- Attacks" of systemic capillary leak syndrome are often preceded by one to two days of one or more nonspecific symptoms, advises the Mayo Clinic. (loire-net.tv)
- Capillary leak syndrome is characterized by the presence of 2 or more of the following 3 symptoms: low blood pressure, swelling, and low levels of protein in the blood. (chemocare.com)
- These could be symptoms of a serious lung condition called acute respiratory distress syndrome (ARDS). (mayoclinic.org)
Hyperpermeability2
- Systemic capillary leak syndrome (ISCLS) is a rare disease characterized by unexplained reversible capillary hyperpermeability followed by hypoperfusion, hemoconcentration, and either hypoalbuminemia or total hypoproteinemia. (hindawi.com)
- The patient suddenly presented with severe edema and hypotension associated with an increased hematocrit and a decreased level of serum albumin, suggesting capillary hyperpermeability. (go.jp)
Recurrent2
- Systemic capillary leak syndrome presenting as recurrent shock. (thefreedictionary.com)
- Recurrent unexplained lipothymia: do not forget the capillary leak syndrome]. (dbcls.jp)
Pulmonary2
- There was no compartment syndrome, rhabdomyolysis, or pulmonary edema in the recovery period. (hindawi.com)
- Since 1991, eight cases of pulmonary leak capilary syndrome have been described associated with pustular or erythrodermic psoriasis induced or not by the use of acitretin or sirolimus - being one of the cases, fatal. (scielo.br)
Endothelial4
- It is characterized by self-reversing episodes during which the endothelial cells which line the capillaries, usually of the extremities, separate for one to three days, causing a leakage of plasma mainly into the muscle compartments of the arms and legs. (wikipedia.org)
- That's why the continuous capillaries in this area don't have any gaps between endothelial cells, and their surrounding basement membrane is also thicker. (healthline.com)
- Loss of endothelial integrity promotes capillary leakage in numerous diseases, including sepsis, but there are no effective therapies for preserving endothelial barrier function. (pnas.org)
- Scheinfeld N. Commentary on Degos disease: a C5b-9/interferon-α-mediated endotheliopathy syndrome by Magro et al: a reconsideration of Degos disease as hematologic or endothelial genetic disease. (medscape.com)
Systemic capillary leakage1
- The very interesting review on the systemic capillary leakage of circulating macromolecules (1) suggests capillary dysfunction. (annals.org)
Acute respirat3
- Significant complications included 6 patients with acute respiratory distress syndrome, 28 patients with infectious complications, and 4 patients with anastomotic complications. (elsevier.com)
- Acute respiratory distress syndrome (ARDS): Evaluate patients who develop fever, lung infiltrates, or respiratory distress. (nih.gov)
- Acute respiratory distress syndrome (ARDS) is a rare complication of generalized pustular psoriasis (GPP). (scielo.br)
Patients14
- The systemic capillary leak syndrome: A case series of 28 patients from a European registry. (mayoclinic.org)
- Capillary protein leak syndrome appears to explain fluid retention in cancer patients who receive docetaxel treatment. (biomedsearch.com)
- One of the patients had a history of capillary leak syndrome and two of the patients have subsequently died. (pharmtech.com)
- Interleukin-11-induced capillary leak syndrome in primary hepatic carcinoma patients with thrombocytopenia. (curehunter.com)
- During routine monitoring, Health Canada became aware of international reports of capillary leak syndrome in patients who were treated with Yondelis. (canada.ca)
- Capillary Leak Syndrome (CLS) which may be life-threatening or fatal if not properly managed, can occur in patients receiving Elzonris. (drugs.com)
- Background: In patients undergoing intraperitoneal (IP) photodynamic therapy (PDT), the combination of aggressive surgical debulking and light therapy causes an apparent systemic capillary-leak syndrome that necessitates significant intensive care unit (ICU) management after surgery. (elsevier.com)
- Conclusions: Patients who undergo surgical debulking and IP PDT develop a significant capillary-leak syndrome after surgery that necessitates massive volume resuscitation, careful ICU monitoring, and, frequently, prolonged ventilatory support. (elsevier.com)
- Based on the clinical features of the patients repeated presentations, a diagnosis of systemic capillary leak syndrome was made and the patient was commenced on oral theophylline. (mysteria.cz)
- Systemic capillary leak syndrome is sometimes observed as a complication in cancer patients being treated with experimental interleukin-2 therapy. (readabstracts.com)
- The most serious late complication is acute renal failure, which occurs in approximately 15 percent of patients with the syndrome. (aafp.org)
- Full recovery can be expected with early diagnosis and treatment of the many complications that can develop in patients with this syndrome. (aafp.org)
- Critically ill patients with acute renal failure are also likely to develop multiorgan failure syndrome, with a resultant increase in mortality. (aafp.org)
- Accofil is indicated for the reduction in the duration of neutropenia and the incidence of febrile neutropenia in patients treated with established cytotoxic chemotherapy for malignancy (with the exception of chronic myeloid leukaemia and myelodysplastic syndromes) and for the reduction in the duration of neutropenia in patients undergoing myeloablative therapy followed by bone marrow transplantation considered to be at increased risk of prolonged severe neutropenia. (medicines.org.uk)
Endothelium1
- The walls of capillaries are made up of a thin cell layer called endothelium that's surrounded by another thin layer called a basement membrane. (healthline.com)
Edema3
- If you have a long-term (chronic) form of the condition, you may experience persistent edema and fluid collection in body cavities without the sudden flares typical of other types of systemic capillary leak syndrome. (mayoclinic.org)
- CONCLUSION: Docetaxel appears to induce an initial enhancement of fluid filtration followed by a capillary protein leakage that leads to edema formation. (biomedsearch.com)
- In case of alteration of the glycocalyx, experimental models and some clinical studies show an increased capillary leak responsible for interstitial edema. (clinicaltrials.gov)
ARDS1
- ARDS can be caused by apulmonary capillary leak syndrome, an infection or by drugs hypersensivity reaction (methotrexate or acitretin) and it seems to be related to cytokines (interleukin 1, tumor necrosis factor α and interleukin 2). (scielo.br)
Dengue fever2
Disease4
- Idiopathic capillary leak syndrome (Clarkson's Disease) is a rare angiopathy with a heterogenous phenotype that may present as distributive shock refractory to resuscitative management. (ovid.com)
- Systemic capillary leak syndrome (Clarkson's disease) during elective pylorus-preserving pancreaticoduodenectomy: case report. (dbcls.jp)
- A case report of systemic capillary leak syndrome (Clarkson's disease). (dbcls.jp)
- Several inherited genetic disorders, such as McArdle's disease and Duchenne's muscular dystrophy, are predisposing factors for the syndrome. (aafp.org)
Vaccine10
- After a review of three cases, EMA's PRAC has advised against the use of Janssen's COVID-19 vaccine in people who have a history of capillary leak syndrome. (pharmtech.com)
- The Pharmacovigilance Risk Assessment Committee (PRAC) of the European Medicines Agency (EMA) has advised against the use of Janssen's COVID-19 vaccine in people who have a history of capillary leak syndrome, it was announced in a July 9, 2021 press release. (pharmtech.com)
- This recommendation has been based on a review of three cases where capillary leak syndrome occurred in people within two days of receiving Janssen's COVID-19 vaccine. (pharmtech.com)
- Capillary leak syndrome is a very rare and serious condition and as a result of PRAC's review, it has been recommended that the condition be added to the product information as a new side effect of the vaccine. (pharmtech.com)
- The AstraZeneca Covid vaccine could now be linked to capillary leak syndrome - a rare disorder characterised by a rapid fall in blood pressure as a result of fluid leaks from capillaries. (loire-net.tv)
- Data has shown the UK's regulator, the Medicines and Healthcare products Regulatory Agency (MHRA), had spotted three cases of capillary leak syndrome out of 20 million people given the AstraZeneca vaccine by late March. (loire-net.tv)
- Health Canada warns of capillary leak syndrome, a possible side effect of the AstraZeneca vaccine. (technicalgaurav.com)
- Home / Latest 2021 News / News 2021 / Us News 2021 / Health Canada warns of capillary leak syndrome, a possible side effect of the AstraZeneca vaccine. (technicalgaurav.com)
- A case of capillary leak syndrome has been reported in Canada following vaccination with the AstraZeneca or COVISHIELD COVID-19 vaccine as of June 11. (technicalgaurav.com)
- Highlights of the EMA's Pharmacovigilance Risk Assessment Committee (PRAC) meeting April 6-9 include that the agency has started a review of a safety signal to assess reports of capillary leak syndrome in people who were vaccinated with Vaxzevria (formerly COVID-19 Vaccine AstraZeneca). (themontserratreporter.com)
Clinical4
- All clinical and laboratory findings supported autoinflammation as the underlying pathogenic mechanism of the syndrome. (ovid.com)
- The data indicate that SCL-like syndrome can be considered a novel clinical syndrome, which can complicate APS. (ovid.com)
- Objective To study the clinical application effect of Xuebijing Injection in the treatment of capillary leak syndrome . (bvsalud.org)
- Rhabdomyolysis, which literally means striated muscle dissolution or disintegration, 1 is a potentially lethal clinical and biochemical syndrome. (aafp.org)
Shock4
- Severe capillary leakage can result in hypotension and shock. (uptodate.com)
- The abdomen, the central nervous system, and the organs (including the lungs) are typically spared, but the extravasation in the extremities is sufficiently massive to cause circulatory shock and compartment syndromes, with a dangerous hypotension (low blood pressure), hemoconcentration (thickening of the blood) and hypoalbuminemia (drop in albumin, a major protein) in the absence of other causes for such abnormalities. (wikipedia.org)
- CLS is seen in conditions such as septic shock or may result from conditions such as multitrauma and pancreatitis, which result in the systemic inflammatory response syndrome (SIRS). (semanticscholar.org)
- Systemic capillary leak syndrome should be considered in the differential diagnosis of multi-organ failure and hypovolemic shock. (semanticscholar.org)
Attacks1
- The systemic capillary leak syndrome: appearance of interleukin-2-receptor-positive cells during attacks. (readabstracts.com)
Sepsis1
- It is a phenomenon most commonly witnessed in sepsis, and less frequently in autoimmune diseases, differentiation syndrome, engraftment syndrome, hemophagocytic lymphohistiocytosis, the ovarian hyperstimulation syndrome, viral hemorrhagic fevers, and snakebite and ricin poisoning. (wikipedia.org)
Pores2
- They're able to do this because they have many larger gaps in their capillary wall, in addition to pores and small gaps. (healthline.com)
- Verapamil blocks calcium-mediated cell contraction, and thus may prevent enlargement of the capillary pores through which the plasma leaks. (readabstracts.com)
Tissues6
- Capillary leak syndrome is characterized by the escape of blood plasma through capillary walls, from the blood circulatory system to surrounding tissues, muscle compartments, organs or body cavities. (wikipedia.org)
- This is why tissues that are very active, such as your muscles, liver , and kidneys , have an abundance of capillaries. (healthline.com)
- The exchange of oxygen, nutrients, and waste between your blood and tissues also happens in your capillaries. (healthline.com)
- This type of capillary is found in areas that require a lot of exchange between your blood and tissues. (healthline.com)
- These types of capillaries are found in certain tissues, including those of your liver , spleen, and bone marrow . (healthline.com)
- Systemic capillary leak syndrome is a rare condition in which plasma leaks from the capillaries into the surrounding tissues. (readabstracts.com)
AstraZeneca2
- The capillary leak syndrome link spells another potential blow for AstraZeneca, after reports of rare blood clots in the brain and abdomen. (loire-net.tv)
- Health Canada is updating the labels for the Oxford-AstraZeneca and COVISHIELD COVID-19 vaccines to add capillary leak syndrome as a possible side effect. (technicalgaurav.com)
Cases6
- PRAC will continue to review and monitor any further cases of capillary leak syndrome post vaccination. (pharmtech.com)
- [3] Some cases of capillary leak are associated with various conditions of the heart, kidney, or liver. (nih.gov)
- At the time of the review, there were no Canadian cases of capillary leak syndrome reported with the use of Yondelis. (canada.ca)
- The review showed that Yondelis played a possible role in 20 cases of capillary leak syndrome. (canada.ca)
- It was difficult to determine how much of a role Yondelis played in the reported cases of capillary leak syndrome because other health conditions could have explained some of the reported medical problems. (canada.ca)
- Two cases of systemic capillary leak syndrome that were treated with pentastarch. (dbcls.jp)
Rhabdomyolysis3
- Systemic capillary leak syndrome associated with rhabdomyolysis and compartment syndrome. (thefreedictionary.com)
- Rhabdomyolysis, acute renal failure, and compartment syndrome in a child with parainfluenza type 1 infection. (semanticscholar.org)
- Rhabdomyolysis is a potentially life-threatening syndrome resulting from the breakdown of skeletal muscle fibers with leakage of muscle contents into the circulation. (aafp.org)
Rare2
- We thank Druey and Greipp for raising awareness of this rare syndrome and would like to complement their excellent review (1) with our anecdotal experience and 3 comments. (annals.org)
- The rare condition sees blood leak from tiny vessels into muscles and body cavities. (thescottishsun.co.uk)
Leakage syndrome1
- One wonders whether similar changes also occur in the generalized leakage syndrome. (annals.org)
Pediatric1
- Here, we present a pediatric patient with the first attack of capillary leak with concordant diabetes mellitus (DM). (hindawi.com)
Severe acute respi1
- The scans showed bilateral scattered ground glass opacities consistent with mild-to-moderate infection with severe acute respiratory syndrome coronavirus 2. (cdc.gov)
Secondary1
- These conditions and factors are sources of secondary capillary leak syndrome. (wikipedia.org)