Capillary Leak Syndrome
Capillary Permeability
The property of blood capillary ENDOTHELIUM that allows for the selective exchange of substances between the blood and surrounding tissues and through membranous barriers such as the BLOOD-AIR BARRIER; BLOOD-AQUEOUS BARRIER; BLOOD-BRAIN BARRIER; BLOOD-NERVE BARRIER; BLOOD-RETINAL BARRIER; and BLOOD-TESTIS BARRIER. Small lipid-soluble molecules such as carbon dioxide and oxygen move freely by diffusion. Water and water-soluble molecules cannot pass through the endothelial walls and are dependent on microscopic pores. These pores show narrow areas (TIGHT JUNCTIONS) which may limit large molecule movement.
Evidence for a structural motif in toxins and interleukin-2 that may be responsible for binding to endothelial cells and initiating vascular leak syndrome. (1/91)
The dose-limiting toxicity of interleukin-2 (IL-2) and immunotoxin (IT) therapy in humans is vascular leak syndrome (VLS). VLS has a complex etiology involving damage to vascular endothelial cells (ECs), extravasation of fluids and proteins, interstitial edema, and organ failure. IL-2 and ITs prepared with the catalytic A chain of the plant toxin, ricin (RTA), and other toxins, damage human ECs in vitro and in vivo. Damage to ECs may initiate VLS; if this damage could be avoided without losing the efficacy of ITs or IL-2, larger doses could be administered. In this paper, we provide evidence that a three amino acid sequence motif, (x)D(y), in toxins and IL-2 damages ECs. Thus, when peptides from RTA or IL-2 containing this sequence motif are coupled to mouse IgG, they bind to and damage ECs both in vitro and, in the case of RTA, in vivo. In contrast, the same peptides with a deleted or mutated sequence do not. Furthermore, the peptide from RTA attached to mouse IgG can block the binding of intact RTA to ECs in vitro and vice versa. In addition, RTA, a fragment of Pseudomonas exotoxin A (PE38-lys), and fibronectin also block the binding of the mouse IgG-RTA peptide to ECs, suggesting that an (x)D(y) motif is exposed on all three molecules. Our results suggest that deletions or mutations in this sequence or the use of nondamaging blocking peptides may increase the therapeutic index of both IL-2, as well as ITs prepared with a variety of plant or bacterial toxins. (+info)Intrapulmonary protein leakage in immunocompromised children and adults with pneumonia. (2/91)
BACKGROUND: Pulmonary infections are associated with an increase in capillary permeability but information regarding age related differences in the local inflammatory response is lacking. To quantify the degree of capillary leakage during inflammation, the concentrations of the plasma proteins albumin, alpha1-antitrypsin, alpha2-macroglobulin and the locally produced proteins elastase, myeloperoxidase, lactoferrin and fibronectin were studied in the bronchoalveolar lavage (BAL) fluid of immunosuppressed children and adults with pneumonia. METHODS: Sixteen children aged 2-16 years and 15 adults who developed pneumonia while receiving immunosuppressive therapy for haematological malignancies were included in the study. Bronchoalveolar lavage was performed via a flexible bronchoscope with three aliquots of 1 ml/kg body weight in children and 200 ml in adults. Protein concentrations in BAL fluid were determined using highly sensitive immunoluminometric assays. RESULTS: Despite considerable variability, the median concentrations of all proteins in BAL fluid were significantly higher in both patient populations than in previously collected age adjusted reference values. The concentrations of serum derived proteins were significantly higher in children with pneumonia than in adult patients. In contrast, no differences were observed between the two groups for locally produced proteins. CONCLUSIONS: These data suggest that the degree of protein exudation is more pronounced in immunosuppressed children with pneumonia than in adults in a similar clinical situation. This is in agreement with our studies in healthy individuals and may reflect a greater permeability of the alveolar-capillary membrane in children, regardless of disease status. (+info)Evidence for the involvement of CD44 in endothelial cell injury and induction of vascular leak syndrome by IL-2. (3/91)
At sites of chronic inflammation seen during infections, autoimmunity, graft-vs-host response, and cytokine therapy, endothelial cell injury is known to occur, the exact mechanism of which is unknown. In the current study we used IL-2-induced vascular leak syndrome (VLS) as a model to investigate whether cytotoxic lymphocytes use CD44 in mediating endothelial cell injury. Administration of IL-2 to wild-type mice triggered significant VLS in the lungs and liver. In contrast, in CD44 knockout (KO) mice, IL-2-induced VLS was markedly reduced in the lungs and liver. IL-2-treated wild-type and CD44 KO mice had similar levels of perivascular infiltration with lymphocytes in the lungs and liver. This suggested that the decrease in VLS seen in CD44 KO mice was not due to the inability of lymphocytes to migrate to these organs. Ultrastructural studies demonstrated extensive endothelial cell damage in the lungs and liver of IL-2-treated wild-type, but not CD44 KO, mice. Moreover, CD44-KO mice exhibited a marked decrease in IL-2-induced lymphokine-activated killer cell activity. The induction of VLS was dependent on the expression of CD44 on immune cells rather than endothelial cells because adoptive transfer of CD44+, but not CD44- spleen cells along with IL-2 into CD44 KO mice triggered VLS. The IL-2-induced VLS was blocked by administration of F(ab')2 of Abs against CD44. The current study demonstrates that CD44 plays a key role in endothelial cell injury. Blocking CD44 in vivo may offer a novel therapeutic approach to prevent endothelial cell injury by cytotoxic lymphocytes in a variety of clinical disease models. (+info)Acute modulation of albumin microvascular leakage by advanced glycation end products in microcirculation of diabetic rats in vivo. (4/91)
Advanced glycation end products (AGEs) are nonenzymatic glycosylated adducts of proteins that accumulate in vascular tissue during diabetes and aging. The aim of this work was to study the role of AGEs and of the oxidative mechanisms in diabetes-induced changes in vascular permeability. Intravital videomicroscopy was used to study albumin microvascular leakage in cremaster muscle. The extravasation of a fluorescent macromolecular tracer (fluorescein isothiocyanate-albumin) was measured for 1 h and, after computer-aided image analysis, was expressed as variations of normalized gray levels (arbitrary units). Extravasation of the macromolecular tracer was much higher in diabetic rats than in control rats (slope of extravasation versus time increased by >100%, P < 10(-4)). This increase was significantly inhibited when we blocked AGEs binding to their endothelial receptor by intravenous bolus of soluble recombinant receptor to AGEs (rR-RAGE) (slope of extravasation versus time decreased by 19, 30, and 40%, for 0.5, 2.5, and 5.15 mg/kg rR-RAGE, respectively) or by a 6 mg/kg intravenous bolus of antibody against RAGE (slope decreased by 53%). Systemic injection of probucol (an antioxidant) also significantly inhibited the increase in the extravasation of the macromolecular tracer occurring in experimental diabetes (slope decreased by 51%, P < 10(-4)). These results strongly suggest that in experimental diabetes the interaction of circulating AGEs and endothelial RAGE mediates albumin micro-vascular leakage, possibly via AGE-RAGE-dependent enhanced oxidant stress. (+info)Adjuvant treatment of severe acute pancreatitis with C1 esterase inhibitor concentrate after haematopoietic stem cell transplantation. (5/91)
BACKGROUND: With an incidence of 4%, acute pancreatitis is a common complication of bone marrow or peripheral haematopoietic stem cell transplantation, which contributes significantly to morbidity and mortality in these patients. In most cases, the pathogenesis of acute pancreatitis cannot be attributed to a single pathogenetic factor, as treatment toxicity, acute graft versus host disease, infection, and cholestasis may all contribute. Acute pancreatitis is characterised by inflammation and activation of digestive proenzymes leading to autodigestive destruction of the pancreas and systemic activation of protease cascades including the complement system. AIM: To describe the effects of human C1 esterase inhibitor in two children, who developed severe acute pancreatitis with considerable complement activation after allogeneic haematopoietic stem cell transplantation. METHODS: Both children showed clinical features resembling those observed in capillary leakage syndrome. In both patients, treatment with C1 esterase inhibitor concentrate contributed to a rapid clinical stabilisation. CONCLUSIONS: These observations strongly support the proposed pathophysiological concept that early treatment with C1 esterase inhibitor interferes with the activation of the complement system in acute pancreatitis. Inhibition of complement activation prevents its adverse effects on vascular function and permeability, and thus stabilises intravascular fluid status and prevents multiorgan failure in acute pancreatitis. (+info)Effect of endothelin and endothelin receptor blockade on capillary permeability in experimental pancreatitis. (6/91)
BACKGROUND: Capillary leakage with fluid loss into the third space contributes to many of the early systemic complications in severe acute pancreatitis. There has been increasing interest in endothelin as one of the factors affecting capillary permeability. AIM: To elucidate further the role of endothelin in the development of capillary leakage in acute pancreatitis by investigating the effect of exogenous endothelin administration and endothelin receptor blockade in sham operated animals and two models of acute pancreatitis. METHODS: Determination of capillary permeability in the pancreas and colonic mucosa by quantifying extravasation of fluorescein labelled dextran using a novel computer assisted video image analysis system. RESULTS: Pancreatic and colonic capillary permeability increased stepwise from mild to severe acute pancreatitis. Endothelin increased pancreatic and colonic capillary permeability in healthy animals and animals with mild acute pancreatitis but had no additional adverse effect in severe acute pancreatitis. Endothelin receptor blockade decreased pancreatic capillary permeability in sham operated rats but had no effect on the colon. In mild and severe acute pancreatitis, endothelin receptor blockade stabilised increased capillary permeability in both the pancreas and colon. CONCLUSIONS: Endothelin plays an important role in mediating capillary permeability in the pancreas. In severe pancreatitis, it increases capillary permeability even outside the pancreas, thereby contributing to capillary leakage. Endothelin receptor blockade significantly reduces capillary permeability in acute pancreatitis both in and outside the pancreas, suggesting a therapeutic approach to counteract capillary leakage in severe acute pancreatitis. (+info)Sensitive blood-retinal barrier breakdown quantitation using Evans blue. (7/91)
PURPOSE: This study investigated whether a nonradioactive dye, Evans blue, can be adapted as a safe alternative to the isotope-dilution method for quantitating blood-retinal barrier breakdown. METHODS: Blood-retinal barrier breakdown was induced in rats with vascular endothelial growth factor (VEGF) or through the induction of diabetes. After allowing Evans blue to circulate in the vasculature, the dye was cleared from the bloodstream with saline, citrate, or citrate-buffered paraformaldehyde, and the efficacies of the perfusion solutions were compared. Extravasated dye was detected at 620 nm and was normalized against the time-averaged Evans blue plasma concentration, the circulation time, and also against wet and dry retina weights. RESULTS: Evans blue leakage from retinas treated with VEGF was 4.0-fold higher than that of contralateral untreated eyes (n = 6 rats, P: < 0.05). Retinal Evans blue leakage of eyes from 1-week diabetic animals (n = 11 retinas) was 1.7-fold higher (P: < 0.05) than that of nondiabetic controls (n = 10 retinas). Intra-animal, inter-retina weights showed significantly less variability (P: < 0.05) with the use of dry weights (11.2%, n = 74 retina pairs) than with wet weights (20.5%, n = 93 retina pairs). CONCLUSIONS: The Evans blue dye technique can be modified to be as sensitive and quantitative as the isotope-dilution method for measuring blood-retinal barrier breakdown. The advantages of the Evans blue technique are its safety, relative simplicity, and economy. (+info)The toxicity of deglycosylated ricin A chain-containing immunotoxins in patients with non-Hodgkin's lymphoma is exacerbated by prior radiotherapy: a retrospective analysis of patients in five clinical trials. (8/91)
A retrospective analysis of 102 patients with relapsed, non-Hodgkin's lymphoma treated with two different ricin A chain-containing immunotoxins (ITs) in five Phase I clinical trials indicates that the dose-limiting toxicity, vascular leak syndrome, was more frequent and more severe in patients who had undergone prior radiotherapy (RT). Excluding patients with prior RT from the calculations of the maximum tolerated dose indicates that the maximum tolerated doses of these ITs had not been reached in any trial and are clearly higher than reported previously. Excluding patients with prior RT from future clinical trials may increase the dose of ITs that can be given in the absence of severe vascular leak syndrome. (+info)
Capillary Leak Syndrome | definition of Capillary Leak Syndrome by Medical dictionary
Capillary leak syndrome - Wikipedia
Systemic Capillary Leak Syndrome
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Capillary leak syndrome
... , or vascular leak syndrome, is characterized by the escape of blood plasma through capillary walls, ... Systemic capillary leak syndrome (SCLS), also called Clarkson's disease, or primary capillary leak syndrome, is a rare, grave ... can also cause capillary leaks. These conditions and factors are sources of secondary capillary leak syndrome. ... engraftment syndrome, hemophagocytic lymphohistiocytosis, the ovarian hyperstimulation syndrome, viral hemorrhagic fevers, and ...
Treatment of lung cancer
... and adult respiratory distress syndrome; capillary leak syndrome; and posterior reversible encephalopathy syndrome. Pemetrexed ...
Interleukin 2
The most common adverse effect of high-dose IL-2 therapy is vascular leak syndrome (VLS; also termed capillary leak syndrome). ... a process mechanistically similar to the vascular leakage syndrome, occurs in tumor tissue only. Disruption of the blood flow ... "Low Dose Interleukin-2 in Patients With Stable Ischaemic Heart Disease and Acute Coronary Syndromes (LILACS)" at ClinicalTrials ...
Gemcitabine
The warning label also states it may cause posterior reversible encephalopathy syndrome, that it may cause capillary leak ... ISBN 978-0-470-09254-5. Siddall E, Khatri M, Radhakrishnan J (July 2017). "Capillary leak syndrome: etiologies, pathophysiology ... syndrome, that it may cause severe lung conditions like pulmonary edema, pneumonia, and adult respiratory distress syndrome, ...
COVID-19 vaccine clinical research
Capillary leak syndrome (CLS) is also being reviewed. The EMA has recommended that people who have had capillary leak syndrome ... "EMA advises against use of COVID-19 Vaccine Janssen in people with history of capillary leak syndrome". European Medicines ... "Study of a Severe Acute Respiratory Syndrome CoV-2 (SARS-CoV-2) Virus-like Particle (VLP) Vaccine in Healthy Adults (COVID-19 ... "Study of a Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) Virus-like Particle (VLP) Vaccine (COVID-19)". ...
Oxford-AstraZeneca COVID-19 vaccine
Capillary leak syndrome is a possible side effect of the vaccine. The European Medicines Agency (EMA) listed Guillain-Barré ... The Oxford-AstraZeneca COVID-19 vaccine should not be administered to people who have had capillary leak syndrome. The most ... EMA advises against use in people with history of capillary leak syndrome". European Medicines Agency (Press release). 11 June ... An increased risk of the rare and potentially fatal thrombosis with thrombocytopenia syndrome (TTS) has been associated with ...
Mehmet Ali Erbil
He currently suffers from a rare disease called capillary leak syndrome. His TV show Çarkıfelek (Turkey's version of Wheel of ...
Targeted molecular therapy for neuroblastoma
These toxicities include neuropathic pain, capillary leak syndrome, and hypersensitivity reaction. Anti-GD2 antibodies have ...
COVID-19 vaccination in Bulgaria
"Vaxzevria: EMA advises against use in people with history of capillary leak syndrome". ema.europa.eu. 11 June 2021. Retrieved ... injection and on 11 June 2021 issued a warning against the administering of this vaccine to people with capillary leak syndrome ... thrombosis with thrombocytopenia syndrome) occurring after the first ...
Disseminated intravascular coagulation
It is not the same as conditions where the blood vessels leak, such as capillary leak syndrome. Under homeostatic conditions, ... HELLP syndrome, thrombotic thrombocytopenic purpura, hemolytic uremic syndrome, and malignant hypertension may mimic DIC but ... 469-471 ISBN 978-1-4160-2973-1 Rak J, Yu JL, Luyendyk J, Mackman N (2006). "Oncogenes, trousseau syndrome, and cancer-related ... Gando, S (1999). "Disseminated intravascular coagulation and sustained systemic inflammatory response syndrome predict organ ...
Retinoic acid syndrome
Several causes have been speculated, including a capillary leak syndrome from cytokine release from the differentiating myeloid ... "Differentiation (retinoic acid) syndrome". Retrieved 10 March 2011. Tallman MS (February 2002). "Retinoic acid syndrome: a ... and to an increasing use of the term differentiation syndrome to signify this APML treatment complication. The syndrome is ... Retinoic acid syndrome (RAS) is a potentially life-threatening complication observed in people with acute promyelocytic ...
Moxetumomab pasudotox
Symptoms of capillary leak syndrome include difficulty breathing, weight gain, hypotension, or swelling of arms, legs and/or ... prescribing information for moxetumomab pasudotox includes a boxed warning about the risk of developing capillary leak syndrome ... The boxed warning also notes the risk of hemolytic uremic syndrome, a condition caused by the abnormal destruction of red blood ... a condition in which fluid and proteins leak out of tiny blood vessels into surrounding tissues. ...
Acute promyelocytic leukemia
The etiology of retinoic acid syndrome has been attributed to capillary leak syndrome from cytokine release from the ... ATRA therapy is associated with the unique side effect of differentiation syndrome. This is associated with the development of ...
POEMS syndrome
While some reports were positive, others have reported capillary leak syndrome suspected to be the result of overly rapid ... POEMS syndrome (also termed osteosclerotic myeloma, Crow-Fukase syndrome, Takatsuki disease, or PEP syndrome) is a rare ... Some features have been observed in patients with POEMS syndrome but are not yet certain to form part of the syndrome itself. ... affected by POEMS syndrome. The diagnosis of POEMS syndrome is based on meeting its two mandatory criteria, meeting at least ...
Hematocrit
Capillary leak syndrome also leads to abnormally high hematocrit counts, because of the episodic leakage of plasma out of the ... In order to maintain pressure, the capillaries branch off to a web of vessels that carry blood into the venules. Through this ... As blood flows through the arterioles, red cells will act a feed hematocrit (Hf), while in the capillaries, a tube hematocrit ( ... The packed cell volume (PCV) can be determined by centrifuging EDTA-treated or heparinized blood in a capillary tube (also ...
Sargramostim
... capillary leak syndrome, a build up of fluid around the lungs and around the heart. Irregular heart rhythms have occurred, ... In March 2018 the label was extended to use as a countermeasure for acute radiation syndrome. "US Sargramostim label" (PDF). ... FDA approves Leukine for Acute Radiation Syndrome. Retrieved 29 March 2018. (Drugs with non-standard legal status, Chemicals ...
Viral hemorrhagic fever
The "VHF syndrome" (capillary leak, bleeding diathesis, and circulatory compromise leading to shock) appears in a majority of ... Olson PE, Hames CS, Benenson AS, Genovese EN (1996). "The Thucydides syndrome: Ebola déjà vu? (or Ebola reemergent?)". Emerging ... The former family Bunyaviridae includes the causative agents of Hantavirus hemorrhagic fever with renal syndrome (HV-HFRS) ( ...
Urticarial syndromes
Muckle-Wells syndrome Familial Mediterranean fever Systemic capillary leak syndrome Physical urticarias List of cutaneous ... There are several distinct urticarial syndromes including: ...
Arturo Porzecanski
Since late 2005, Porzecanski has struggled with an exceedingly rare illness, Systemic Capillary Leak Syndrome (SCLS), which ... in list of AU/CLALS Research Fellows Porzecanski in Wilson Center website Porzecanski in Systemic Capillary Leak Syndrome ... He also persuaded the National Institutes of Health to carry out basic biomedical research on this syndrome. In early 2009, ...
Gleich's syndrome
... but it is unrelated to capillary leak syndrome (which may cause similar swelling episodes) and eosinophilia-myalgia syndrome ( ... Gleich's syndrome is not a form of the idiopathic hypereosinophilic syndrome in that there is little or no evidence that it ... Gleich syndrome has a good prognosis. Attack severity may improve with steroid treatment. Gleich GJ, Schroeter AL, Marcoux JP, ... Gleich's syndrome is a rare disease in which the body swells up episodically (angioedema), associated with raised antibodies of ...
List of diseases (C)
... syndrome Cantu-Sanchez-Corona-Garcia syndrome Cantu-Sanchez-Corona-Hernandes syndrome Capillary leak syndrome Capillary leak ... CCA syndrome Ccge syndrome CCHS CDG syndrome CDG syndrome type 1A CDG syndrome type 1B CDG syndrome type 1C CDG syndrome type 2 ... syndrome Coffin-Siris syndrome COFS syndrome Cogan-Reese syndrome Cogan syndrome Cohen-Gibson syndrome Cohen-Hayden syndrome ... syndrome type 1 Cockayne syndrome type 2 Cockayne syndrome type 3 Cockayne's syndrome Codas syndrome Codesette syndrome Coeliac ...
SCLS
Capillary leak syndrome a rare medical condition where the number and size of the pores in the capillaries are increased which ...
Dinutuximab
... and capillary leak syndrome. Other common adverse effects include retention or urine for weeks to months after receiving the ...
Anasarca
Right-sided heart failure Severe protein deficiency Nephrotic syndrome Protein-losing enteropathies Capillary leak syndrome In ...
Tagraxofusp
In addition, the medicine could cause capillary leak syndrome (an unpredictable, potentially life-threatening side effect due ...
Paeniclostridium sordellii
... persistent apyrexia and profound capillary leak syndrome (see entry for Clostridium novyi alpha-toxin for details of mechanism ... Severe toxic shock syndrome among previously healthy persons has been described in a small number of C. sordellii cases, most ...
Lipopolysaccharide
Damage to the endothelial layer of blood vessels caused by these inflammatory mediators can lead to capillary leak syndrome, ... have also been implicated with Guillain-Barré syndrome and a variant of Guillain-Barré called Miller-Fisher syndrome. ... Waterhouse-Friderichsen syndrome, and meningitis. Portions of the LPS from several bacterial strains have been shown to be ... which is likely to develop on the basis of the small bowel bacterial overgrowth syndrome and an increased intestinal ...
Polycythemia
Anemia, a decrease in red blood cell count Cytopenia, a decrease in blood cell count Capillary leak syndrome, another cause of ... A specific type of relative polycythemia is Gaisböck syndrome. In this syndrome, primarily occurring in obese men, hypertension ... Couck I, Lewi L (June 2016). "The Placenta in Twin-to-Twin Transfusion Syndrome and Twin Anemia Polycythemia Sequence". Twin ... The recipient twin in a pregnancy undergoing twin-to-twin transfusion syndrome can have polycythemia. The pathophysiology of ...
List of syndromes
Cantú syndrome Capgras delusion Capgras syndrome Capillary leak syndrome Caplan's syndrome Carcinoid syndrome Cardiac syndrome ... syndrome Wende-Bauckus syndrome Werner syndrome Wernicke-Korsakoff syndrome West syndrome Westerhof syndrome Wet lung syndrome ... syndrome Lynch syndrome Lyngstadaas syndrome Löffler's syndrome Löfgren syndrome M74 syndrome Macrocephaly-capillary ... syndrome Shone's syndrome Short anagen syndrome Short bowel syndrome short limb syndrome Short man syndrome Short QT syndrome ...
Irvine-Gass syndrome
... causing the capillaries in the retina to dilate and leak fluid into the retina. This is less common today with modern lens ... The syndrome is named in honor of S. Rodman Irvine and J. Donald M. Gass. The incidence is more common in older types of ... Irvine-Gass syndrome, pseudophakic cystoid macular edema or postcataract CME is one of the most common causes of visual loss ... v t e (Articles with short description, Short description is different from Wikidata, Syndromes affecting the eye, All stub ...
Bumblebee
The tip of the tongue probably acts as a suction cup and during lapping, nectar may be drawn up the proboscis by capillary ... and take a while to leak away into the ground. They use this information to find out if a flower has been recently visited by ... Bumblebees generally visit flowers that exhibit the bee pollination syndrome and these patches of flowers may be up to 1-2 km ...
Liver support system
Budd Chiari syndrome) Hypoxic hepatitis Liver failure during pregnancy or Reye syndrome Unknown etiology Goals of MARS Therapy ... Cryogel pores range in size from 10-100 µm in size, forming an interconnected network that mimics a capillary system with a ... Blood leak detection in the albumin circuit Disseminated intravascular coagulation (DIC) Severe active hemorrhage Federal Drug ... Pierre Versin is one of the pioneers in the study of hepatorenal syndrome in patients with liver impairment. Great efforts have ...
Acute inhalation injury
In the acute phase of ALI, there is increased permeability of this barrier and protein rich fluid leaks out of the capillaries ... Morrison RJ, Bidani A. (2002) Acute respiratory distress syndrome epidemiology and pathophysiology. Chest Surg Clin N Am. 12: ... A recent chlorine gas leak in Pune, India, landed 20 individuals in the hospital. Though that was an accidental exposure, ... The direct toxicity to the cells leads to an increase in capillary permeability. Furthermore, when phosgene hydrolyzes it forms ...
Glycolysis
In addition, it blocks the glucose from leaking out - the cell lacks transporters for G6P, and free diffusion out of the cell ... During their genesis, limited capillary support often results in hypoxia (decreased O2 supply) within the tumor cells. Thus, ... "A reappraisal of the blood glucose homeostat which comprehensively explains the type 2 diabetes mellitus-syndrome X complex". ...
List of skin conditions
Reflex cold urticaria Schnitzler syndrome Secondary cold contact urticaria Solar urticaria Systemic capillary leak syndrome ... Turner syndrome Ulnar-mammary syndrome Van Der Woude syndrome Von Hippel-Lindau syndrome Watson syndrome Werner syndrome (adult ... Freeman-Sheldon syndrome, Windmill-Vane-Hand syndrome) Wilson-Turner syndrome Wolf-Hirschhorn syndrome (4p- syndrome) X-linked ... Rombo syndrome Rothmund-Thomson syndrome (poikiloderma congenitale) Rud syndrome Say syndrome Scalp-ear-nipple syndrome (Finlay ...
Dengue fever
Fluid from the bloodstream leaks through the wall of small blood vessels into body cavities due to capillary permeability. As a ... Shock (dengue shock syndrome) and hemorrhage (dengue hemorrhagic fever) occur in less than 5% of all cases of dengue; however, ... Leaky capillaries (and the critical phase) are thought to be caused by an immune system response. Other processes of interest ... Dengue shock syndrome is present if pulse pressure drops to ≤ 20 mm Hg along with peripheral vascular collapse. Peripheral ...
Glossary of diabetes
Syndrome X/Metabolic syndrome See: Metabolic syndrome. Syringe Systemic Conditions that affect the entire body. Diabetes is a ... At one end of a capillary is a connection to the body's arteries and at the other end of a capillary is a connection to the ... There are two varieties, the bleeding sort in which a blood vessel leaks blood into tissues. In the brain, these produce ... Metabolic syndrome (syndrome X, insulin resistance syndrome) A set of signs and symptoms correlated with both insulin ...
Diabetic retinopathy
People with Down syndrome, who have extra chromosome 21 material, almost never acquire diabetic retinopathy. This protection ... Later, the basement membrane of the retinal blood vessels thickens, capillaries degenerate and lose cells, particularly ... or blood leaking into the vitreous humor ("vitreous hemorrhage") or between the vitreous membrane and retina ("preretinal ... 2017, "Risk factors". Ryeom S, Folkman J (March 2009). "Role of endogenous angiogenesis inhibitors in Down syndrome". The ...
Glossary of underwater diving terminology: P-S
... gas will leak out, rather than water leaking in, which provides a more secure airway and provides some protection against ... salt water aspiration syndrome A reaction of the lungs to inhalation of a mist of salt water samba Involuntary muscular ... perfusion The process of delivery of blood to a capillary bed in the biological tissue. perfusion limited The assumption in a ... pulmonary over-inflation syndrome Pulmonary barotrauma of ascent. Lung over-pressure injury. purge To press the purge button on ...
Facioscapulohumeral muscular dystrophy
... syndrome' or 'type of muscular dystrophy') Erb-Landouzy-Dejerine syndrome[citation needed] Early drug trials, before the ... Abnormalities of the capillaries and venules are not observed. One theory for why the arterioles are selectively affected is ... CK is an enzyme found in muscle, leaking into the blood when muscles become damaged. In FSHD, CK level is normal to mildly ... Landouzy-Dejerine syndrome, whonamedit.com, date accessed March 11, 2007 Landouzy; Dejerine (1884). "De la myopathie atrophique ...
Interventional radiology
... muscular arterioles and thin-walled capillaries. In contrast to arteries, capillaries have thin single-layered walls, so oxygen ... Root pain syndromes, known colloquially as radiculitis (i.e., sciatica) are one of the most common symptoms caused by damage to ... Some stents are bare-metal, allowing blood to leak through the walls of the stent, while others have a thin covering that keeps ... Pelvic congestion syndrome usually affects women who have previously been pregnant, because the ovarian veins and pelvic veins ...
Angiopathy
In microangiopathy, the walls of the smaller blood vessels become so thick and weak that they bleed, leak protein, and slow the ... Angiopathy is the generic term for a disease of the blood vessels (arteries, veins, and capillaries). The best known and most ... Kimmelstiel-Wilson syndrome). It is also possible to classify angiopathy by the associated condition:[citation needed] Diabetic ...
Sepsis
Hyperinflammatory syndromes such as hemophagocytic lymphohistiocytosis (HLH) may have similar symptoms and are on the ... Glucose levels taken from capillary blood should be interpreted with care because such measurements may not be accurate. If a ... Increased permeability of the lung vessels causes leaking of fluids into alveoli, which results in pulmonary edema and acute ... In 2016 a new consensus was reached to replace screening by systemic inflammatory response syndrome (SIRS) with the sequential ...
Cerebrospinal fluid
If a leak is identified, a beta-2 transferrin test of the leaking fluid, when positive, is highly specific and sensitive for ... For example, when CSF pressure is higher, there is less of a pressure difference between the capillary blood in choroid ... paraneoplastic syndromes, systemic lupus erythematosus, neurosarcoidosis, cerebral angiitis; and specific antibodies such as ... Medical imaging such as CT scans and MRI scans can be used to investigate for a presumed CSF leak when no obvious leak is found ...
Carbon monoxide poisoning
... typically flu-like viral syndromes, depression, chronic fatigue syndrome, chest pain, and migraine or other headaches. Carbon ... Following an explosion in a colliery, adjacent interconnected mines may become dangerous due to the afterdamp leaking from mine ... In the brain this causes further mitochondrial dysfunction, capillary leakage, leukocyte sequestration, and apoptosis. The ... Other conditions included in the differential diagnosis include acute respiratory distress syndrome, altitude sickness, lactic ...
Doxorubicin
Following administration of this form of doxorubicin, small amounts of the drug can leak from capillaries in the palms of the ... In clinical testing at 50 mg/m2 dosing every 4 weeks, half of people developed hand-foot syndrome. The rate of this side effect ... more commonly known as hand-foot syndrome. ...
Poikiloderma vasculare atrophicans
Rothmund-Thomson syndrome, Kindler syndrome, dyskeratosis congenita, and chronic radiodermatitis. Rare causes include arsenic ... Pigmentation changes in PVA, apparent in the epidermal (outermost) skin layer, may be attributed to incontinence (leaking out) ... Telangiectasia is an enlargement of capillaries underneath the skin. PVA also has common names that include parapsoriasis- ... PVA fits within this updated view of parapsoriasis as a syndrome often associated with large plaque parapsoriasis and, or ...
Lie detection
His studies use micro-expressions, which last less than one-fifth of a second, and "may leak emotions someone wants to conceal ... Luke's Medical Center in Chicago, explained the "Pinocchio Syndrome" or "Pinocchio effect" as: blood rushes to the nose when ... They also may consider respiration rate, blood pressure, capillary dilation, and muscular movement. While taking a polygraph ... Game W. Gifford Jones (26 July 2010). "Can 'Pinocchio Syndrome' solve the niqab dilemma?". pressreader.com. The Telegram. ...
Aneurysm
602 Connective tissue disorders such as Loeys-Dietz syndrome, Marfan syndrome, and certain forms of Ehlers-Danlos syndrome are ... Capillaries, specifically capillary aneurysms. The Large vessels such as external and internal jugular veins Cerebral aneurysms ... This blood-filled cavity will eventually either thrombose (clot) enough to seal the leak or rupture out of the surrounding ... Vascular Ehlers-Danlos Syndrome. 1999 Sep 2 [Updated 2019 Feb 21]. In: Adam MP, Ardinger HH, Pagon RA, et al., editors. ...
Periorbital puffiness
Allergic reactions can lead to leaks in the subcutaneous capillary beds which can cause swelling in the face, including around ... Cavernous sinus syndrome polyneuropathy. Mononucleosis - With supra-orbital oedema, the eyes become puffy and swollen. This may ... Nephrotic syndrome - Puffiness around the eyes is the first site to get swollen.[citation needed] Trichinosis - Periorbital ...
Capillary leak syndrome in dengue fever.
Capillary leak syndrome (CLS) has been described in dengue fever but its exact features have not been clearly defined. We ... Capillary leak syndrome in dengue fever.. dc.contributor.author. Verma, Sudhir Kumar. ... Capillary leak syndrome in dengue fever. Dengue Bulletin. 2011 Dec; 35: 65-70.. EN. ... Capillary leak syndrome. EN. dc.title. Capillary leak syndrome in dengue fever.. EN. ...
Capillary leak syndrome in dengue fever.
Capillary leak syndrome (CLS) has been described in dengue fever but its exact features have not been clearly defined. We ... Capillary leak syndrome in dengue fever. Dengue Bulletin. 2011 Dec; 35: 65-70. ... 2011). Capillary leak syndrome in dengue fever.. WHO Regional Office for South-East Asia.. https://extranet.who.int/iris/ ...
Table 3 - Fatal Exacerbations of Systemic Capillary Leak Syndrome Complicating Coronavirus Disease - Volume 27, Number 10...
Vaxzevria (previously COVID-19 Vaccine AstraZeneca): contraindication in individuals with previous capillary leak syndrome |...
... contraindication in individuals with previous capillary leak syndrome ... Vaxzevria (previously COVID-19 Vaccine AstraZeneca): contraindication in individuals with previous capillary leak syndrome. ... contraindication in individuals with previous capillary leak syndrome (PDF/145.61 KB) First published: 23/06/2021 Dissemination ...
Fatal Systemic Capillary Leak Syndrome after SARS-CoV-2 Vaccination in Patient with Multiple Myeloma - Volume 27, Number 11...
Matheny M, Maleque N, Channell N, Eisch AR, Auld SC, Banerji A, et al. Severe exacerbations of systemic capillary leak syndrome ... Idiopathic systemic capillary leak syndrome (Clarkson disease). J Allergy Clin Immunol. 2017;140:663-70. DOIPubMedGoogle ... Capillary leak syndrome: etiologies, pathophysiology, and management. Kidney Int. 2017;92:37-46. DOIPubMedGoogle Scholar ... Systemic capillary leak syndrome after influenza vaccination in a peritoneal dialysis patient. Perit Dial Int. 2015;35:772-3. ...
Chronic systemic capillary leak syndrome associated with an intravascular large B-cell lymphoma in a patient undergoing...
... and hypoalbuminemia associated with increased capillary endothelium permeability. Patients with a chronic form of SCLS present ... Systemic capillary leak syndrome (SCLS) is a rare disorder characterized by hypotension, hemoconcentration, ... Systemic capillary leak syndrome (Clarkson syndrome) in cancer patients: a systematic review. J Clin Med. 2018;7:418. ... Sunohara, K., Shimizu, R., Yasuda, K. et al. Chronic systemic capillary leak syndrome associated with an intravascular large B- ...
Vaxzevria: EMA Advises Against Use In People With History Of Capillary Leak Syndrome
... has concluded that people who have previously had capillary leak syndrome must not be vaccinated with Vaxzevria (formerly ... Capillary leak syndrome is a very rare, serious condition that causes fluid leakage from small blood vessels (capillaries), ... The Committee carried out an in-depth review of 6 cases of capillary leak syndrome in people who had received Vaxzevria.1 Most ... Three of those affected had a history of capillary leak syndrome and one of them subsequently died. As of 27 May 2021, more ...
Capillary Leak Syndrome (Idiopathic Systemic Capillary Leak Syndrome): Symptoms, Diagnosis and Treatment - Symptoma
Idiopathic Systemic Capillary Leak Syndrome): Read more about Symptoms, Diagnosis, Treatment, Complications, Causes and ... Symptoms Attacks of systemic capillary leak syndrome are often preceded by one to two days of one or more nonspecific symptoms ... Symptoms Attacks of systemic capillary leak syndrome are often preceded by one to two days of one or more nonspecific symptoms ... 28238385 ) AlyeA9il C....GA1ney S. 2017 30 Epidemiology, risk factors, and prognosis of capillary leak syndrome in pediatric ...
Health Canada Recommends People With Capillary Leak Syndrome Not to Receive AstraZeneca Vaccine - CultureMagazin®
Warning tied to capillary leak syndrome. On Tuesday, Health Canada also recommended that people with a history of capillary ... Capillary leak syndrome (CLS) is a very rare, serious condition that causes fluid leakage from small blood vessels (capillaries ... Earlier this month, the European Medicines Agencys safety committee said that capillary leak syndrome must be added as a new ... Until June 11, one case of capillary leak syndrome following vaccination with AstraZenecas vaccine has been reported in Canada ...
DailyMed - FULPHILA- pegfilgrastim injection
5.8 Capillary Leak Syndrome Capillary leak syndrome has been reported after G-CSF administration, including pegfilgrastim, and ... Capillary Leak Syndrome [see Warnings and Precautions (5.8)] •. Injection site reactions •. Sweets syndrome, (acute febrile ... 5.8 Capillary Leak Syndrome 5.9 Potential for Tumor Growth Stimulatory Effects on Malignant Cells 5.10 Myelodysplastic Syndrome ... Capillary Leak Syndrome. Fulphila can cause fluid to leak from blood vessels into your bodys tissues. This condition is called ...
Figure - Fatal Exacerbations of Systemic Capillary Leak Syndrome Complicating Coronavirus Disease - Volume 27, Number 10...
Fatal Exacerbations of Systemic Capillary Leak Syndrome Complicating Coronavirus Disease Patricia C. Cheung, A. Robin Eisch, ... Fatal Exacerbations of Systemic Capillary Leak Syndrome Complicating Coronavirus Disease. ... with new-onset systemic capillary leak syndrome and coronavirus disease showing A) the upper and B) lower lung fields in axial ... bilateral scattered ground glass opacities consistent with mild-to-moderate infection with severe acute respiratory syndrome ...
Aldesleukin: MedlinePlus Drug Information
Intravenous Immunoglobulin: Overview, Uses of Intravenous Immunoglobulin, Pharmacology and Monitoring
Monoclonal gammopathy-associated systemic capillary-leak syndrome, also known as Clarkson disease, is a rare condition ... Intravenous immunoglobulins improve survival in monoclonal gammopathy-associated systemic capillary-leak syndrome. Am J Med. ... and long-term outcome of monoclonal gammopathy-associated systemic capillary-leak syndrome. Since this condition is ... Patients with ataxic sensory neuronopathy with Sjögren syndrome and stiff man syndrome have benefited from IVIG therapy. ...
Red Ears: Causes, Treatments, and More
Capillary leak syndrome is a rare disorder that causes a dramatic drop in blood pressure. Early diagnosis is important to ... Red ear syndrome. Red ear syndrome is rare. Symptoms include episodes of redness and burning, particularly in the ear lobe. ... To treat red ear syndrome. There isnt a straightforward treatment approach to red ear syndrome. There are some medications ... 2013). The red ear syndrome. DOI: 10.1186/1129-2377-14-83. *Mayo Clinic Staff. (2015). Cellulitis. http://www.mayoclinic.org/ ...
COVID-19 vaccines and records | Alberta.ca
Capillary leak syndrome. *Guillain-Barré syndrome (GBS). * AstraZeneca (COVISHIELD) vaccine (no longer available in Alberta). ... Individuals with moderate to severe primary immunodeficiency (for example, DiGeorge syndrome, Wiskott-Aldrich syndrome) ... Thrombosis with Thrombocytopenia Syndrome (TTS). The U.S. Food and Drug Administration reports the risk of TTS following ... Individuals with advanced untreated HIV infection or acquired immunodeficiency syndrome (AIDS). *Recipients of ...
NIOSHTIC-2 Search Results - Basic View
Fresenius Kabi Receives U.S. FDA Approval for Biosimilar Stimufend® (pegfilgrastim - fpgk) | Business Wire
Capillary Leak Syndrome (CLS) has been reported after G-CSF administration, including pegfilgrastim products. ... Myelodysplastic Syndrome (MDS) and Acute Myeloid Leukemia (AML) have been associated with the use of pegfilgrastim products in ... Acute Respiratory Distress Syndrome (ARDS) can occur in patients receiving pegfilgrastim products. Evaluate patients who ...
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Pulmonary capillary leak syndrome following COVID-19 virus infection. J Med Virol. doi: 10.1002/jmv.26152. ... Pulmonary capillary leak syndrome following COVID-19 virus infection. J Med Virol. doi: 10.1002/jmv.26152. ... Pulmonary capillary leak syndrome following COVID-19 virus infection. . J Med Virol. doi: 10.1002/jmv.26152. .. ), false ... Pulmonary capillary leak syndrome following COVID-19 virus infection. . J Med Virol. doi: 10.1002/jmv.26152. .. ), false ...
Yondelis (trabectedin) dosing, indications, interactions, adverse effects, and more
LUMOXITI Dosage & Rx Info | Uses, Side Effects
Side Effects of Ifex (Ifosfamide), Warnings, Uses
Pulmonary embolism, Deep vein thrombosis, Capillary leak syndrome, Vasculitis, Hypertension, Flushing, Blood pressure decreased ... Syndrome of inappropriate antidiuretic hormone secretion (SIADH). Metabolism And Nutrition Disorders. Tumor lysis syndrome, ... Toxic epidermal necrolysis, Stevens-Johnson syndrome, Palmar-plantar erythrodysesthesia syndrome, Radiation recall dermatitis, ... Fanconi syndrome, Tubulointerstitial nephritis, Nephrogenic diabetes insipidus, Phosphaturia, Aminoaciduria, Polyuria, Enuresis ...
Tagraxofusp Effective for BPDCN - NCI
... of participants experienced a potentially serious side effect called capillary leak syndrome, in which fluids and proteins leak ... Capillary leak syndrome is also a side effect of other drugs that contain the same toxin as tagraxofusp, Dr. Lane noted. The ... "With vigilant monitoring and early interventions, capillary leak syndrome was manageable," the study authors wrote. One ... FDA approval of tagraxofusp includes a warning and outlines factors that may increase the risk of capillary leak syndrome, such ...
Preoperative prediction of pediatric patients with effusions and edema following cardiopulmonary bypass surgery by serological...
This suggests that preoperative differences in the immune system and capillary permeability status exist in patients at risk ... Postoperative effusions and edema and capillary leak syndrome in children after cardiac surgery with cardiopulmonary bypass ... acute respiratory distress syndrome, or even capillary leak syndrome (CLS) or multiple organ dysfunction (MOD) or failure, with ... Stieh J, Harding P, Scheewe J, Duetschke P, Kramer HH: Capillary leak syndrome after open heart surgery for congenital heart ...
Acute Kidney Injury in the Modern Era of Allogeneic Hematopoietic Stem Cell Transplantation | American Society of Nephrology
Capillary leak syndrome: Etiologies, pathophysiology, and management. Kidney Int 92: 37-46, 2017. ... sinusoidal obstructive syndrome (three of 21), TMA (three of 21), CNI nephrotoxicity (five of 21), tumor lysis syndrome (two of ... sinusoidal obstructive syndrome (three of 64; 5%), tumor lysis syndrome (two of 64; 3%), and suspected BK virus nephropathy ( ... Nephrotic syndrome after hematopoietic cell transplantation: Do glomerular lesions represent renal graft-versus-host disease? ...
Coronavirus Now: COVID-19 & Vaccine Updates for Today | Heavy.com
The EMA is also investigating capillary leak syndrome after five cases were reported following the AstraZeneca vaccine. ... Guillain-Barre Syndrome. The FDA has added a warning to the Johnson & Johnson vaccine about a rare Guillain-Barre syndrome side ... The EMA is studying erythema multiforme (a skin reaction), glomerulonephritis (kidney inflammation), and nephrotic syndrome (a ... The EMA is studying erythema multiforme (a skin reaction), glomerulonephritis (kidney inflammation), and nephrotic syndrome (a ...
Pfizer, Feds at Odds Over Third Dose; No Spectators at Olympics; 'Trashy' Hospital | MedPage Today
Accessing ROLVEDON™ (eflapegrastim-xnst) | Patient Support
Capillary Leak Syndrome. *Capillary leak syndrome has been reported after administration of rhG-CSF products and is ... Myelodysplastic Syndrome (MDS) and Acute Myeloid Leukemia (AML) in Patients with Breast and Lung Cancer. *MDS and AML have been ... Acute Respiratory Distress Syndrome (ARDS). *ARDS can occur in patients receiving rhG-CSF products. Evaluate patients who ...
Issue 21 | RIVM
In addition, one person has died of systemic capillary leak syndrome (SCLS) following vaccination with the Janssen vaccine. ... To date, Lareb has received one report of thrombosis with thrombocytopenia syndrome (TTS) following a Janssen vaccination. ... on selecting and inviting young people who are eligible to receive the flu jab and young people with Downs syndrome. Young ...