Capillary Leak Syndrome: A condition characterized by recurring episodes of fluid leaking from capillaries into extra-vascular compartments causing hematocrit to rise precipitously. If not treated, generalized vascular leak can lead to generalized EDEMA; SHOCK; cardiovascular collapse; and MULTIPLE ORGAN FAILURE.Capillary Permeability: The property of blood capillary ENDOTHELIUM that allows for the selective exchange of substances between the blood and surrounding tissues and through membranous barriers such as the BLOOD-AIR BARRIER; BLOOD-AQUEOUS BARRIER; BLOOD-BRAIN BARRIER; BLOOD-NERVE BARRIER; BLOOD-RETINAL BARRIER; and BLOOD-TESTIS BARRIER. Small lipid-soluble molecules such as carbon dioxide and oxygen move freely by diffusion. Water and water-soluble molecules cannot pass through the endothelial walls and are dependent on microscopic pores. These pores show narrow areas (TIGHT JUNCTIONS) which may limit large molecule movement.Hypoproteinemia: A condition in which total serum protein level is below the normal range. Hypoproteinemia can be caused by protein malabsorption in the gastrointestinal tract, EDEMA, or PROTEINURIA.Dictionaries, MedicalLymphoma, Large B-Cell, Diffuse: Malignant lymphoma composed of large B lymphoid cells whose nuclear size can exceed normal macrophage nuclei, or more than twice the size of a normal lymphocyte. The pattern is predominantly diffuse. Most of these lymphomas represent the malignant counterpart of B-lymphocytes at midstage in the process of differentiation.Health Personnel: Men and women working in the provision of health services, whether as individual practitioners or employees of health institutions and programs, whether or not professionally trained, and whether or not subject to public regulation. (From A Discursive Dictionary of Health Care, 1976)United States Food and Drug Administration: An agency of the PUBLIC HEALTH SERVICE concerned with the overall planning, promoting, and administering of programs pertaining to maintaining standards of quality of foods, drugs, therapeutic devices, etc.Pharmacology: The study of the origin, nature, properties, and actions of drugs and their effects on living organisms.Drug-Related Side Effects and Adverse Reactions: Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chemically-induced adverse conditions due to toxicity, DRUG INTERACTIONS, and metabolic effects of pharmaceuticals.Pharmacology, Clinical: The branch of pharmacology that deals directly with the effectiveness and safety of drugs in humans.Attitude of Health Personnel: Attitudes of personnel toward their patients, other professionals, toward the medical care system, etc.Adverse Drug Reaction Reporting Systems: Systems developed for collecting reports from government agencies, manufacturers, hospitals, physicians, and other sources on adverse drug reactions.Canada: The largest country in North America, comprising 10 provinces and three territories. Its capital is Ottawa.American Cancer Society: A voluntary organization concerned with the prevention and treatment of cancer through education and research.Hematopoietic Stem Cell Transplantation: Transfer of HEMATOPOIETIC STEM CELLS from BONE MARROW or BLOOD between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). Hematopoietic stem cell transplantation has been used as an alternative to BONE MARROW TRANSPLANTATION in the treatment of a variety of neoplasms.Stem Cells: Relatively undifferentiated cells that retain the ability to divide and proliferate throughout postnatal life to provide progenitor cells that can differentiate into specialized cells.Transplantation, Homologous: Transplantation between individuals of the same species. Usually refers to genetically disparate individuals in contradistinction to isogeneic transplantation for genetically identical individuals.Graft vs Host Disease: The clinical entity characterized by anorexia, diarrhea, loss of hair, leukopenia, thrombocytopenia, growth retardation, and eventual death brought about by the GRAFT VS HOST REACTION.Stem Cell Transplantation: The transfer of STEM CELLS from one individual to another within the same species (TRANSPLANTATION, HOMOLOGOUS) or between species (XENOTRANSPLANTATION), or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). The source and location of the stem cells determines their potency or pluripotency to differentiate into various cell types.Body Weight: The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.Weight Loss: Decrease in existing BODY WEIGHT.Hypotension: Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DIZZINESS but greater negative impacts on the body occur when there is prolonged depravation of oxygen and nutrients.Diet, Reducing: A diet designed to cause an individual to lose weight.Weight Gain: Increase in BODY WEIGHT over existing weight.Obesity: A status with BODY WEIGHT that is grossly above the acceptable or desirable weight, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).Energy Intake: Total number of calories taken in daily whether ingested or by parenteral routes.Interferon-beta: One of the type I interferons produced by fibroblasts in response to stimulation by live or inactivated virus or by double-stranded RNA. It is a cytokine with antiviral, antiproliferative, and immunomodulating activity.Multiple Sclerosis, Relapsing-Remitting: The most common clinical variant of MULTIPLE SCLEROSIS, characterized by recurrent acute exacerbations of neurologic dysfunction followed by partial or complete recovery. Common clinical manifestations include loss of visual (see OPTIC NEURITIS), motor, sensory, or bladder function. Acute episodes of demyelination may occur at any site in the central nervous system, and commonly involve the optic nerves, spinal cord, brain stem, and cerebellum. (Adams et al., Principles of Neurology, 6th ed, pp903-914)Interferons: Proteins secreted by vertebrate cells in response to a wide variety of inducers. They confer resistance against many different viruses, inhibit proliferation of normal and malignant cells, impede multiplication of intracellular parasites, enhance macrophage and granulocyte phagocytosis, augment natural killer cell activity, and show several other immunomodulatory functions.Multiple Sclerosis: An autoimmune disorder mainly affecting young adults and characterized by destruction of myelin in the central nervous system. Pathologic findings include multiple sharply demarcated areas of demyelination throughout the white matter of the central nervous system. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia, and bladder dysfunction. The usual pattern is one of recurrent attacks followed by partial recovery (see MULTIPLE SCLEROSIS, RELAPSING-REMITTING), but acute fulminating and chronic progressive forms (see MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE) also occur. (Adams et al., Principles of Neurology, 6th ed, p903)Adjuvants, Immunologic: Substances that augment, stimulate, activate, potentiate, or modulate the immune response at either the cellular or humoral level. The classical agents (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contain bacterial antigens. Some are endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Their mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy of many biological response modifiers is related to their antigen-specific immunoadjuvanticity.Acneiform Eruptions: Visible efflorescent lesions of the skin caused by acne or resembling acne. (Dorland, 28th ed, p18, 575)Interferon Type I: Interferon secreted by leukocytes, fibroblasts, or lymphoblasts in response to viruses or interferon inducers other than mitogens, antigens, or allo-antigens. They include alpha- and beta-interferons (INTERFERON-ALPHA and INTERFERON-BETA).Shock: A pathological condition manifested by failure to perfuse or oxygenate vital organs.Compartment Syndromes: Conditions in which increased pressure within a limited space compromises the BLOOD CIRCULATION and function of tissue within that space. Some of the causes of increased pressure are TRAUMA, tight dressings, HEMORRHAGE, and exercise. Sequelae include nerve compression (NERVE COMPRESSION SYNDROMES); PARALYSIS; and ISCHEMIC CONTRACTURE.Drug Recalls: Removal of a drug from the market due to a problem occurring in the manufacture or distribution of the product.Rhabdomyolysis: Necrosis or disintegration of skeletal muscle often followed by myoglobinuria.Glycogen Storage Disease Type V: Glycogenosis due to muscle phosphorylase deficiency. Characterized by painful cramps following sustained exercise.Hyperkalemia: Abnormally high potassium concentration in the blood, most often due to defective renal excretion. It is characterized clinically by electrocardiographic abnormalities (elevated T waves and depressed P waves, and eventually by atrial asystole). In severe cases, weakness and flaccid paralysis may occur. (Dorland, 27th ed)MyoglobinuriaMuscular Dystrophies: A heterogeneous group of inherited MYOPATHIES, characterized by wasting and weakness of the SKELETAL MUSCLE. They are categorized by the sites of MUSCLE WEAKNESS; AGE OF ONSET; and INHERITANCE PATTERNS.Muscular Dystrophy, Duchenne: An X-linked recessive muscle disease caused by an inability to synthesize DYSTROPHIN, which is involved with maintaining the integrity of the sarcolemma. Muscle fibers undergo a process that features degeneration and regeneration. Clinical manifestations include proximal weakness in the first few years of life, pseudohypertrophy, cardiomyopathy (see MYOCARDIAL DISEASES), and an increased incidence of impaired mentation. Becker muscular dystrophy is a closely related condition featuring a later onset of disease (usually adolescence) and a slowly progressive course. (Adams et al., Principles of Neurology, 6th ed, p1415)Urinalysis: Examination of urine by chemical, physical, or microscopic means. Routine urinalysis usually includes performing chemical screening tests, determining specific gravity, observing any unusual color or odor, screening for bacteriuria, and examining the sediment microscopically.Scleroderma, Systemic: A chronic multi-system disorder of CONNECTIVE TISSUE. It is characterized by SCLEROSIS in the SKIN, the LUNGS, the HEART, the GASTROINTESTINAL TRACT, the KIDNEYS, and the MUSCULOSKELETAL SYSTEM. Other important features include diseased small BLOOD VESSELS and AUTOANTIBODIES. The disorder is named for its most prominent feature (hard skin), and classified into subsets by the extent of skin thickening: LIMITED SCLERODERMA and DIFFUSE SCLERODERMA.Scleroderma, Diffuse: A rapid onset form of SYSTEMIC SCLERODERMA with progressive widespread SKIN thickening over the arms, the legs and the trunk, resulting in stiffness and disability.Scleroderma, Limited: The least progressive form of SYSTEMIC SCLERODERMA with skin thickening restricted to the face, neck and areas distal to the elbows and/or knees, sparing the trunk. The CREST SYNDROME is a form of limited scleroderma.Pulmonary Fibrosis: A process in which normal lung tissues are progressively replaced by FIBROBLASTS and COLLAGEN causing an irreversible loss of the ability to transfer oxygen into the bloodstream via PULMONARY ALVEOLI. Patients show progressive DYSPNEA finally resulting in death.Raynaud Disease: An idiopathic vascular disorder characterized by bilateral Raynaud phenomenon, the abrupt onset of digital paleness or CYANOSIS in response to cold exposure or stress.Fibrosis: Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other injury.Immunoglobulins, Intravenous: Immunoglobulin preparations used in intravenous infusion, containing primarily IMMUNOGLOBULIN G. They are used to treat a variety of diseases associated with decreased or abnormal immunoglobulin levels including pediatric AIDS; primary HYPERGAMMAGLOBULINEMIA; SCID; CYTOMEGALOVIRUS infections in transplant recipients, LYMPHOCYTIC LEUKEMIA, CHRONIC; Kawasaki syndrome, infection in neonates, and IDIOPATHIC THROMBOCYTOPENIC PURPURA.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Models, Biological: Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.Immunoglobulin G: The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.Immunoglobulins: Multi-subunit proteins which function in IMMUNITY. They are produced by B LYMPHOCYTES from the IMMUNOGLOBULIN GENES. They are comprised of two heavy (IMMUNOGLOBULIN HEAVY CHAINS) and two light chains (IMMUNOGLOBULIN LIGHT CHAINS) with additional ancillary polypeptide chains depending on their isoforms. The variety of isoforms include monomeric or polymeric forms, and transmembrane forms (B-CELL ANTIGEN RECEPTORS) or secreted forms (ANTIBODIES). They are divided by the amino acid sequence of their heavy chains into five classes (IMMUNOGLOBULIN A; IMMUNOGLOBULIN D; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M) and various subclasses.Mucocutaneous Lymph Node Syndrome: An acute, febrile, mucocutaneous condition accompanied by swelling of cervical lymph nodes in infants and young children. The principal symptoms are fever, congestion of the ocular conjunctivae, reddening of the lips and oral cavity, protuberance of tongue papillae, and edema or erythema of the extremities.Immunologic Factors: Biologically active substances whose activities affect or play a role in the functioning of the immune system.

Evidence for a structural motif in toxins and interleukin-2 that may be responsible for binding to endothelial cells and initiating vascular leak syndrome. (1/91)

The dose-limiting toxicity of interleukin-2 (IL-2) and immunotoxin (IT) therapy in humans is vascular leak syndrome (VLS). VLS has a complex etiology involving damage to vascular endothelial cells (ECs), extravasation of fluids and proteins, interstitial edema, and organ failure. IL-2 and ITs prepared with the catalytic A chain of the plant toxin, ricin (RTA), and other toxins, damage human ECs in vitro and in vivo. Damage to ECs may initiate VLS; if this damage could be avoided without losing the efficacy of ITs or IL-2, larger doses could be administered. In this paper, we provide evidence that a three amino acid sequence motif, (x)D(y), in toxins and IL-2 damages ECs. Thus, when peptides from RTA or IL-2 containing this sequence motif are coupled to mouse IgG, they bind to and damage ECs both in vitro and, in the case of RTA, in vivo. In contrast, the same peptides with a deleted or mutated sequence do not. Furthermore, the peptide from RTA attached to mouse IgG can block the binding of intact RTA to ECs in vitro and vice versa. In addition, RTA, a fragment of Pseudomonas exotoxin A (PE38-lys), and fibronectin also block the binding of the mouse IgG-RTA peptide to ECs, suggesting that an (x)D(y) motif is exposed on all three molecules. Our results suggest that deletions or mutations in this sequence or the use of nondamaging blocking peptides may increase the therapeutic index of both IL-2, as well as ITs prepared with a variety of plant or bacterial toxins.  (+info)

Intrapulmonary protein leakage in immunocompromised children and adults with pneumonia. (2/91)

BACKGROUND: Pulmonary infections are associated with an increase in capillary permeability but information regarding age related differences in the local inflammatory response is lacking. To quantify the degree of capillary leakage during inflammation, the concentrations of the plasma proteins albumin, alpha1-antitrypsin, alpha2-macroglobulin and the locally produced proteins elastase, myeloperoxidase, lactoferrin and fibronectin were studied in the bronchoalveolar lavage (BAL) fluid of immunosuppressed children and adults with pneumonia. METHODS: Sixteen children aged 2-16 years and 15 adults who developed pneumonia while receiving immunosuppressive therapy for haematological malignancies were included in the study. Bronchoalveolar lavage was performed via a flexible bronchoscope with three aliquots of 1 ml/kg body weight in children and 200 ml in adults. Protein concentrations in BAL fluid were determined using highly sensitive immunoluminometric assays. RESULTS: Despite considerable variability, the median concentrations of all proteins in BAL fluid were significantly higher in both patient populations than in previously collected age adjusted reference values. The concentrations of serum derived proteins were significantly higher in children with pneumonia than in adult patients. In contrast, no differences were observed between the two groups for locally produced proteins. CONCLUSIONS: These data suggest that the degree of protein exudation is more pronounced in immunosuppressed children with pneumonia than in adults in a similar clinical situation. This is in agreement with our studies in healthy individuals and may reflect a greater permeability of the alveolar-capillary membrane in children, regardless of disease status.  (+info)

Evidence for the involvement of CD44 in endothelial cell injury and induction of vascular leak syndrome by IL-2. (3/91)

At sites of chronic inflammation seen during infections, autoimmunity, graft-vs-host response, and cytokine therapy, endothelial cell injury is known to occur, the exact mechanism of which is unknown. In the current study we used IL-2-induced vascular leak syndrome (VLS) as a model to investigate whether cytotoxic lymphocytes use CD44 in mediating endothelial cell injury. Administration of IL-2 to wild-type mice triggered significant VLS in the lungs and liver. In contrast, in CD44 knockout (KO) mice, IL-2-induced VLS was markedly reduced in the lungs and liver. IL-2-treated wild-type and CD44 KO mice had similar levels of perivascular infiltration with lymphocytes in the lungs and liver. This suggested that the decrease in VLS seen in CD44 KO mice was not due to the inability of lymphocytes to migrate to these organs. Ultrastructural studies demonstrated extensive endothelial cell damage in the lungs and liver of IL-2-treated wild-type, but not CD44 KO, mice. Moreover, CD44-KO mice exhibited a marked decrease in IL-2-induced lymphokine-activated killer cell activity. The induction of VLS was dependent on the expression of CD44 on immune cells rather than endothelial cells because adoptive transfer of CD44+, but not CD44- spleen cells along with IL-2 into CD44 KO mice triggered VLS. The IL-2-induced VLS was blocked by administration of F(ab')2 of Abs against CD44. The current study demonstrates that CD44 plays a key role in endothelial cell injury. Blocking CD44 in vivo may offer a novel therapeutic approach to prevent endothelial cell injury by cytotoxic lymphocytes in a variety of clinical disease models.  (+info)

Acute modulation of albumin microvascular leakage by advanced glycation end products in microcirculation of diabetic rats in vivo. (4/91)

Advanced glycation end products (AGEs) are nonenzymatic glycosylated adducts of proteins that accumulate in vascular tissue during diabetes and aging. The aim of this work was to study the role of AGEs and of the oxidative mechanisms in diabetes-induced changes in vascular permeability. Intravital videomicroscopy was used to study albumin microvascular leakage in cremaster muscle. The extravasation of a fluorescent macromolecular tracer (fluorescein isothiocyanate-albumin) was measured for 1 h and, after computer-aided image analysis, was expressed as variations of normalized gray levels (arbitrary units). Extravasation of the macromolecular tracer was much higher in diabetic rats than in control rats (slope of extravasation versus time increased by >100%, P < 10(-4)). This increase was significantly inhibited when we blocked AGEs binding to their endothelial receptor by intravenous bolus of soluble recombinant receptor to AGEs (rR-RAGE) (slope of extravasation versus time decreased by 19, 30, and 40%, for 0.5, 2.5, and 5.15 mg/kg rR-RAGE, respectively) or by a 6 mg/kg intravenous bolus of antibody against RAGE (slope decreased by 53%). Systemic injection of probucol (an antioxidant) also significantly inhibited the increase in the extravasation of the macromolecular tracer occurring in experimental diabetes (slope decreased by 51%, P < 10(-4)). These results strongly suggest that in experimental diabetes the interaction of circulating AGEs and endothelial RAGE mediates albumin micro-vascular leakage, possibly via AGE-RAGE-dependent enhanced oxidant stress.  (+info)

Adjuvant treatment of severe acute pancreatitis with C1 esterase inhibitor concentrate after haematopoietic stem cell transplantation. (5/91)

BACKGROUND: With an incidence of 4%, acute pancreatitis is a common complication of bone marrow or peripheral haematopoietic stem cell transplantation, which contributes significantly to morbidity and mortality in these patients. In most cases, the pathogenesis of acute pancreatitis cannot be attributed to a single pathogenetic factor, as treatment toxicity, acute graft versus host disease, infection, and cholestasis may all contribute. Acute pancreatitis is characterised by inflammation and activation of digestive proenzymes leading to autodigestive destruction of the pancreas and systemic activation of protease cascades including the complement system. AIM: To describe the effects of human C1 esterase inhibitor in two children, who developed severe acute pancreatitis with considerable complement activation after allogeneic haematopoietic stem cell transplantation. METHODS: Both children showed clinical features resembling those observed in capillary leakage syndrome. In both patients, treatment with C1 esterase inhibitor concentrate contributed to a rapid clinical stabilisation. CONCLUSIONS: These observations strongly support the proposed pathophysiological concept that early treatment with C1 esterase inhibitor interferes with the activation of the complement system in acute pancreatitis. Inhibition of complement activation prevents its adverse effects on vascular function and permeability, and thus stabilises intravascular fluid status and prevents multiorgan failure in acute pancreatitis.  (+info)

Effect of endothelin and endothelin receptor blockade on capillary permeability in experimental pancreatitis. (6/91)

BACKGROUND: Capillary leakage with fluid loss into the third space contributes to many of the early systemic complications in severe acute pancreatitis. There has been increasing interest in endothelin as one of the factors affecting capillary permeability. AIM: To elucidate further the role of endothelin in the development of capillary leakage in acute pancreatitis by investigating the effect of exogenous endothelin administration and endothelin receptor blockade in sham operated animals and two models of acute pancreatitis. METHODS: Determination of capillary permeability in the pancreas and colonic mucosa by quantifying extravasation of fluorescein labelled dextran using a novel computer assisted video image analysis system. RESULTS: Pancreatic and colonic capillary permeability increased stepwise from mild to severe acute pancreatitis. Endothelin increased pancreatic and colonic capillary permeability in healthy animals and animals with mild acute pancreatitis but had no additional adverse effect in severe acute pancreatitis. Endothelin receptor blockade decreased pancreatic capillary permeability in sham operated rats but had no effect on the colon. In mild and severe acute pancreatitis, endothelin receptor blockade stabilised increased capillary permeability in both the pancreas and colon. CONCLUSIONS: Endothelin plays an important role in mediating capillary permeability in the pancreas. In severe pancreatitis, it increases capillary permeability even outside the pancreas, thereby contributing to capillary leakage. Endothelin receptor blockade significantly reduces capillary permeability in acute pancreatitis both in and outside the pancreas, suggesting a therapeutic approach to counteract capillary leakage in severe acute pancreatitis.  (+info)

Sensitive blood-retinal barrier breakdown quantitation using Evans blue. (7/91)

PURPOSE: This study investigated whether a nonradioactive dye, Evans blue, can be adapted as a safe alternative to the isotope-dilution method for quantitating blood-retinal barrier breakdown. METHODS: Blood-retinal barrier breakdown was induced in rats with vascular endothelial growth factor (VEGF) or through the induction of diabetes. After allowing Evans blue to circulate in the vasculature, the dye was cleared from the bloodstream with saline, citrate, or citrate-buffered paraformaldehyde, and the efficacies of the perfusion solutions were compared. Extravasated dye was detected at 620 nm and was normalized against the time-averaged Evans blue plasma concentration, the circulation time, and also against wet and dry retina weights. RESULTS: Evans blue leakage from retinas treated with VEGF was 4.0-fold higher than that of contralateral untreated eyes (n = 6 rats, P: < 0.05). Retinal Evans blue leakage of eyes from 1-week diabetic animals (n = 11 retinas) was 1.7-fold higher (P: < 0.05) than that of nondiabetic controls (n = 10 retinas). Intra-animal, inter-retina weights showed significantly less variability (P: < 0.05) with the use of dry weights (11.2%, n = 74 retina pairs) than with wet weights (20.5%, n = 93 retina pairs). CONCLUSIONS: The Evans blue dye technique can be modified to be as sensitive and quantitative as the isotope-dilution method for measuring blood-retinal barrier breakdown. The advantages of the Evans blue technique are its safety, relative simplicity, and economy.  (+info)

The toxicity of deglycosylated ricin A chain-containing immunotoxins in patients with non-Hodgkin's lymphoma is exacerbated by prior radiotherapy: a retrospective analysis of patients in five clinical trials. (8/91)

A retrospective analysis of 102 patients with relapsed, non-Hodgkin's lymphoma treated with two different ricin A chain-containing immunotoxins (ITs) in five Phase I clinical trials indicates that the dose-limiting toxicity, vascular leak syndrome, was more frequent and more severe in patients who had undergone prior radiotherapy (RT). Excluding patients with prior RT from the calculations of the maximum tolerated dose indicates that the maximum tolerated doses of these ITs had not been reached in any trial and are clearly higher than reported previously. Excluding patients with prior RT from future clinical trials may increase the dose of ITs that can be given in the absence of severe vascular leak syndrome.  (+info)

Looking for online definition of Capillary Leak Syndrome in the Medical Dictionary? Capillary Leak Syndrome explanation free. What is Capillary Leak Syndrome? Meaning of Capillary Leak Syndrome medical term. What does Capillary Leak Syndrome mean?
Capillary leak syndrome is characterized by the escape of blood plasma through capillary walls, from the blood circulatory system to surrounding tissues, muscle compartments, organs or body cavities. It is a phenomenon most commonly witnessed in sepsis, and less frequently in autoimmune diseases, differentiation syndrome, engraftment syndrome, hemophagocytic lymphohistiocytosis, the ovarian hyperstimulation syndrome, viral hemorrhagic fevers, and snakebite and ricin poisoning. Pharmaceuticals, including the chemotherapy medication gemcitabine, as well as certain interleukins and monoclonal antibodies, can also cause capillary leaks. These conditions and factors are sources of secondary capillary leak syndrome. Systemic capillary leak syndrome (SCLS, or Clarksons disease), or primary capillary leak syndrome, is a rare, grave and episodic medical condition observed largely in otherwise healthy individuals mostly in middle age. It is characterized by self-reversing episodes during which the ...
... (SCLS) is characterized by recurrent hypovolemic shock attributable to increased systemic capillary leakage. A 46-year-old man was admitted to our hospital because of recurrent episodes of generalized edema with hypovolemic shock. Blood laboratory data revealed severe hypoproteinemia with a small monoclonal IgG-κ protein. These findings suggested strongly the diagnosis of SCLS. A regimen with steroid pulse therapy was tried; however, intravascular overloading accompanied by the recruitment of the initially extravasated fluids resulted in acute pulmonary edema. Intensive care and careful monitoring of fluid volume are required in SCLS ...
We report on a 75-year-old woman who presented with recurrent episodes of hypotension, anasarca, renal failure, hypoalbuminaemia without proteinuria, suggestive of systemic capillary leak syndrome (SCLS). Further investigations led to a diagnosis of diffuse large B-cell lymphoma. Secondary SCLS associated with non-Hodgkin lymphoma is reviewed. ...
The systemic capillary leak syndrome (SCLS) can be a dramatic, perplexing, and terrifying disease to treat, particularly in its initial presentation. We have treated a patient with recurrent SCLS and have consulted by telephone on another patient. We thank Druey and Greipp for raising awareness of this rare syndrome and would like to complement their excellent review (1) with our anecdotal experience and 3 comments ...
Recurrent hypovolemic shock due to leakage of plasma from the vascular space without an apparent cause was first described by Clarkson and colleagues (1) in 1960 and was subsequently characterized as systemic capillary leak syndrome (2). Since then, 18 patients have been described, most of whom had an M component in their plasma (3). However, the pathogenesis of this syndrome remains unknown. A clue may come from the fact that the syndrome is also a major complication of treatment of metastatic cancer with interleukin-2 alone or in combination with lymphokine-activated killer cells (4). Studies in animals and in humans showed ...
No one knows exactly what causes this disorder. It doesnt appear to be inherited. One study reports that it is caused by chemicals in the body that damage or temporarily separate the cells lining the capillary walls. This separation allows the walls to become leaky.. With treatment, you may be able to control the disorder and avert attacks for long periods of time. If you have a long-term (chronic) form of the condition, you may experience persistent edema and fluid collection in body cavities without the sudden flares typical of other types of systemic capillary leak syndrome.. ...
Another serious, but very uncommon side effect of sargramostim is "capillary leak syndrome" or "vascular leak syndrome." Capillary leak syndrome is a potentially serious disease in which fluids within the vascular system (veins and capillaries) leaks into the tissue outside the bloodstream. This results in low blood pressure and poor blood flow to the internal organs. Capillary leak syndrome is characterized by the presence of 2 or more of the following 3 symptoms; low blood pressure, swelling, and low levels of protein in the blood. Your doctor will monitor these things carefully while you are taking sargramostim. You should notify your doctor immediately if you notice dizziness (especially when changing position), sudden swelling or rapid weight gain, little or no urine output (for 8-12 hours), shortness of breath, difficulty breathing, irregular heart beats, or chest pain ...
Systemic Capillary Leak Syndrome (SCLS) is a rare disorder characterized by increased capillary hyperpermeability leading to hypovolemic shock due to a markedly increased shift of fluid and protein from the intravascular to the interstitial space. Hemoconcentration, hypoalbuminemia and a monoclonal gammopathy are characteristic laboratory findings. Here we present a patient who suffered from SCLS with hypovolemic shock and compartment syndrome of both lower legs and thighs. Volume and catecholamine management was guided using transpulmonary thermodilution. Extended hemodynamic monitoring for volume and catecholamine management as well as monitoring of muscle compartment pressure is of crucial importance in SCLS patients.
A 40-year-old woman was referred to our hospital with severe hypovolemic shock and anasarca. The laboratory findings showed marked hemoconcentration and a decrease in total serum protein with the presence of monoclonal IgG-λ. She had had a similar episode of generalized edema 2 years previously. We diagnosed the patient as having typical systemic capillary leak syndrome (SCLS) and she improved gradually after infusion of albumin-containing fluid. SCLS is a very rare condition caused by unexplained episodic capillary hyperpermeability. Its treatment has remained largely supportive and the prognosis is generally poor. Awareness of SCLS is necessary for improvement of the outcome.,br,(Internal Medicine 41: 211-215, 2002). ...
Allogeneic stem cell transplantation is commonly used in the treatment of younger patients with severe hematological diseases, and endothelial cells seem to be important for the development of several posttransplant complications. Capillary leak syndrome is a common early posttransplant complication where endothelial cell dysfunction probably contributes to the pathogenesis. In the present study we investigated whether the pretreatment serum metabolic profile reflects a risk of posttransplant capillary leak syndrome. We investigated the pretransplant serum levels of 766 metabolites for 80 consecutive allotransplant recipients. Patients with later capillary leak syndrome showed increased pretherapy levels of metabolites associated with endothelial dysfunction (homocitrulline, adenosine) altered renal regulation of fluid and/or electrolyte balance (betaine, methoxytyramine, and taurine) and altered vascular function (cytidine, adenosine, and methoxytyramine). Additional bioinformatical analyses ...
Connor Thompson of Danielson suffers from systemic capillary leak syndrome, or Clarksons disease. He is one of only five children in the country with this disease. Today is Rare Disease Day, an awareness event marked all over the world.
Temperature programmed desorption (TPD) is a method for obtaining information about quantities and binding properties of adsorbed species on a surface. A microfabricated flow system for TPD with an integrated capillary leak to a mass spectrometer is presented. The use of an integrated capillary leak minimizes dead volumes in the system, resulting in increased sensitivity and reduced response time. These properties make the system ideal for TPD experiments in a carrier gas. With CO desorbing from platinum as model system, it is shown that CO desorbing in 105 Pa of argon from as little as 0.5 cm2 of platinum foil gives a clear desorption peak. By using the microfabricated flow system, TPD experiments can be performed in a carrier gas with a sensitivity approaching that of TPD experiments in vacuum. ©2004 American Institute of Physics ...
Contraindications. BLINCYTO® is contraindicated in patients with a known hypersensitivity to blinatumomab or to any component of the product formulation.. Warnings and Precautions. Cytokine Release Syndrome (CRS): Life-threatening or fatal CRS occurred in patients receiving BLINCYTO®. Infusion reactions have occurred and may be clinically indistinguishable from manifestations of CRS. Closely monitor patients for signs and symptoms of serious events such as pyrexia, headache, nausea, asthenia, hypotension, increased alanine aminotransferase (ALT), increased aspartate aminotransferase (AST), increased total bilirubin (TBILI), disseminated intravascular coagulation (DIC), capillary leak syndrome (CLS), and hemophagocytic lymphohistiocytosis/macrophage activation syndrome (HLH/MAS). Interrupt or discontinue BLINCYTO® as outlined in the Prescribing Information (PI). Neurological Toxicities: Approximately 50% of patients receiving BLINCYTO® in clinical trials experienced neurological toxicities. ...
BLINCYTO® is contraindicated in patients with a known hypersensitivity to blinatumomab or to any component of the product formulation.. Warnings and Precautions. Cytokine Release Syndrome (CRS): Life-threatening or fatal CRS occurred in patients receiving BLINCYTO®. Infusion reactions have occurred and may be clinically indistinguishable from manifestations of CRS. Closely monitor patients for signs and symptoms of serious events such as pyrexia, headache, nausea, asthenia, hypotension, increased alanine aminotransferase (ALT), increased aspartate aminotransferase (AST), increased total bilirubin (TBILI), disseminated intravascular coagulation (DIC), capillary leak syndrome (CLS), and hemophagocytic lymphohistiocytosis/macrophage activation syndrome (HLH/MAS). Interrupt or discontinue BLINCYTO® as outlined in the Prescribing Information (PI). Neurological Toxicities: Approximately 50% of patients receiving BLINCYTO® in clinical trials experienced neurological toxicities. Severe, ...
CYTOKINE RELEASE SYNDROME (CRS): CRS occurred in 94% of patients, including 13% with ≥ Grade 3. Among patients who died after receiving Yescarta, 4 had ongoing CRS at death. The median time to onset was 2 days (range: 1-12 days) and median duration was 7 days (range: 2-58 days). Key manifestations include fever (78%), hypotension (41%), tachycardia (28%), hypoxia (22%), and chills (20%). Serious events that may be associated with CRS include cardiac arrhythmias (including atrial fibrillation and ventricular tachycardia), cardiac arrest, cardiac failure, renal insufficiency, capillary leak syndrome, hypotension, hypoxia, and hemophagocytic lymphohistiocytosis/macrophage activation syndrome. Ensure that 2 doses of tocilizumab are available prior to infusion of Yescarta. Monitor patients at least daily for 7 days at the certified healthcare facility following infusion for signs and symptoms of CRS. Monitor patients for signs or symptoms of CRS for 4 weeks after infusion. Counsel patients to seek ...
Introduction Drowning with submersion over 10 minutes is associated with a high mortality. Here, we present a case, in which a good neurological outcome was achieved after interdisciplinary, intensive care therapy despite submersion of 20 minutes followed by 16 hours of hypoxia. History A 19 year old man drowned in fresh-water. After 20 minutes submersion he was localized and salvaged from 8 meters depth and primarily resuscitated successfully after 10 minutes. Within the next hour, there condition worsened by respiratory deterioration due to a massive capillary leak syndrome in addition to a disseminated intravascular coagulation ...
After an NCI-led Phase II study combining the vaccine with Interleukin-2 (IL-2) showed response rates of 42 percent in metastatic melanoma patients, a Phase III randomized trial with the two agents opened more than a decade ago. Conducting a large, multi-institutional trial with IL-2, however, had its own set of unique challenges, explained Hwu, as not all cancer centers and community hospitals are capable of administering the immunotherapy. A highly specialized therapy associated with such significant side effects as low blood pressure and capillary leak syndrome, which poses risks to the heart and lung, IL-2 is often delivered in intensive care units. Just last month, M. D. Anderson opened a special in-patient unit exclusively designed for the drugs delivery; before, the institution was offering the therapy in its ICU.. In the Phase III trial, 185 patients at 21 centers across the country were enrolled in the study. All had advanced metastatic melanoma and were stratified for cutaneous ...
Leukine as awarded, and manufactured by Sanofi in Bridgewater NJ will not work as a thrombosome. Edema, capillary leak syndrome, pleural and/or pericardial effusion, sequestration of granulocytes in the pulmonary circulation, and dyspnea have been reported in patients after Leukine administration. Occasional transient supraventricular arrhythmia has been reported during Leukine administration. Leukine has induced the elevation of serum creatinine or bilirubin and hepatic enzymes in some patients. Monitoring of renal and hepatic function in patients with preexisting renal or hepatic dysfunction is recommended at least every other week during Leukine administration.. ReplyDelete ...
Toxic shock syndrome (TSS) is caused by an overwhelming host-mediated response to bacterial superantigens produced mainly by Staphylococcus aureus and Streptococcus pyogenes. TSS is characterized by aberrant activation of T cells and excessive release of pro-inflammatory cytokines ultimately resulting in capillary leak, septic shock, multiple organ dysfunction and high mortality rates. No therapeutic or vaccine has been approved by the U.S. Food and Drug Administration for TSS, and novel therapeutic strategies to improve clinical outcome are needed. Mesenchymal stromal (stem) cells (MSCs) are stromal cells capable of self-renewal and differentiation. Moreover, MSCs have immunomodulatory properties, including profound effects on activities of T cells and macrophages in specific contexts. Based on the critical role of host-derived immune mediators in TSS, we hypothesized that MSCs could modulate the host-derived proinflammatory response triggered by Staphylococcal enterotoxin B (SEB) and improve survival
imately half of the cases and its occurrence in the LT setting has been considered an ominous sign. A diffuse alveolar reexpansion, triggering endothelial activation damage involves both the endothelial and epithelial and neutrophil sequestration (priming event). This surfaces and disrupts the lung barrier. Cardinal clinical event would be followed by local enhancement of the features of ARDS are the insidious onset of refractory inflammatory cascade by attracting and activating cir- hypoxemia and bilateral pulmonary infiltrates, but no culating proinflammatory cytokines, antibodies and primed cells generated upon reperfusion, hepatic fail- REPE is a form of non-diffuse, permeability-type PE ure, or TRALI, resulting in endothelial damage and that occasionally occurs following acute evacuation of capillary leak (second-hit).2 In addition, the release of air or fluid from the pleural space, allowing rapid expan- inflammatory mediators into the systemic circulation sion of a long period ...
Septic shock is a life-threatening condition requiring intense patient monitoring and supportive therapy for organ dysfunction. Release of inflammatory mediators leads to widespread vasodilatation, capillary leak and reduced systemic vascular resistance. After initial fluid resuscitation, vasopressor therapy is required. These agents have their effect by increasing vascular resistance, raising mean arterial pressure and maintaining perfusion of critical body tissues and organ systems. ...
Contrary to popular belief, NIMV does NOT push edema fluid out of the lungs. Patients with acute CHF have an imbalance in the CO (cardiac output) of the right and left sides of the heart. With the inciting event (detailed above) the left ventricle becomes compromised but the right ventricle usually does not. So the right ventricle continues to pump forward a normal volume of blood but the left ventricle becomes unable to keep pace. Fluid backs up into the lungs resulting in capillary leak and pulmonary edema. With NIMV, the resultant positive intra-thoracic pressure decreases venous return (blood flowing back to the heart). This reduces right-sided CO to a level that the left heart can equal or even exceed. Fluid ceases to back up and will even begin to be reabsorbed as left ventricular CO improves. Pulmonary edema ceases to worsen and may even diminish, often rapidly ...
I know it sounds obvious. But in cerbral oedema lets say due to vasgenic cause,the problem is cerebral vessels becoming more permeable and leaking out blood to extravascular compartment. Now how does the brain get bigger due to this. I mean for brain to get bigger, the intracellular fluid volume of brain cells must increase. So when these capillaries leak blood out, do near by brain cells absorb these water, increasing their intracellular volume and as a result we get enlarged brain? or does this leaked out fluid get stuck in brain interstitium making it bigger. I hope u understand my confusion, because leaking out fluid must make brain smaller otherwise. Thanks ...
Preclinical laboratory experiments with Interleukin 15 (IL-15) have demonstrated significant immunotherapeutic potential for recombinant human IL-15 (rhIL-15) in cancer patients. We have completed a first-in-human (FIH), phase I dose escalation trial of E. coli produced rhIL-15 administered as a 30 minute intravenous bolus (IVB) infusion given daily for 12 consecutive days to patients with metastatic melanoma (MM) or renal cell carcinoma (mRCC). rhIL-15 treatment produced up to an 8-fold expansion of circulating NK cells, approximately 2 fold expansion of CD8+ CD45RO+ memory T-cells and up to 50 fold increases in serum level for multiple cytokines. Characteristic toxicities associated with cytokine treatment such as fever, rigors or chills, capillary leak, myalgias and blood pressure changes occurred at frequency and severity proportional to the dose of rhIL-15. Laboratory results showed early course transient leukopenia, lymphopenia, modest neutropenia, occasional thrombocytopenia and ...
This leads to B cell triggering and internalization of the antigen. 156 Immunologic Concepts 21 The result is that a signal for B cell triggering is delivered, activating intracellular pathways which include the calcium-dependent pathway. To recruit antigen-specific T cell help, B cells must present peptides of allogeneic MHC antigen in the groove of its class II antigens. To accomplish this, the allogeneic MHC antigen bound by sIg is endocytosed, through proteins around the receptor termed α and β,156 and presented as peptides in the class II groove of the B cell. Platelet activating factor (PAF) has been demonstrated in the EC plasma membranes and may act locally on adhering leukocytes. 175,176 Other influences include eicosanoids such as the vasodilator prostacyclin (PGI2) or the vasoconstrictor thromboxane. 177 It is likely that the balance between these two forces contributes to the complex vasomotor changes such as arterial vasoconstriction and capillary leak in acute rejection. 172 ...
Successful antibiotic therapy in the critically ill requires sufficient drug concentrations at the site of infection that kill or suppress bacterial growth. The relationship between antibiotic exposure and achieving the above effects is referred to as pharmacokinetics/pharmacodynamics (PK/PD). The associated indices therefore provide logical targets for optimal antibiotic therapy. While dosing regimens to achieve such targets have largely been established from studies in animals and non-critically ill patients, they are often poorly validated in the ICU. Endothelial dysfunction, capillary leak, altered major organ blood flow, deranged plasma protein concentrations, extremes of body habitus, the application of extracorporeal support modalities, and a higher prevalence of intermediate susceptibility, independently, and in combination, significantly confound successful antibiotic treatment in this setting. As such, the prescription of standard doses are likely to result in sub-therapeutic ...
The alpha chain of the Il2 receptor, also known as Tac or CD25, is expressed on activated T and B cells, on regulatory T cells (Treg), and to a lesser degree on subpopulations of resting memory T cells (1-5). Tac is also expressed on multiple T- and B-cell malignancies and is therefore a target for cancer therapy (6). LMB-2 is an anti-Tac recombinant immunotoxin (RIT) containing a targeting scFv and a 38-kDa portion of Pseudomonas exotoxin A (PE38) that shows extremely high cytotoxic activity and has been evaluated in several clinical trials (6-9). One such clinical trial involved various hematologic malignancies, including adult T-cell leukemia, B-cell chronic lymphocytic leukemia, anaplastic large-cell lymphomas, B-cell non-Hodgkin lymphoma, Hodgkin disease, and hairy cell leukemia (6). In this trial, a general 3% complete remission and a 20% partial remission rate was observed, with 37% of immunotoxin recipients generating antidrug antibodies (ADA) and with vascular leak syndrome (VLS) ...
A27 Immunotoxins, a class of biologic therapeutics provide efficacious and specific treatment for cancer as they target surface specific growth factor receptors or antigens over expressed on cancer cells. Immunotoxins have shown promising results in vitro and in vivo. One of the immunotoxin approved for use by FDA is denileukin diftitox; major toxicities with this drug are acute hypersensitivity, vascular leak syndrome and impaired immune function. The latter two toxicities are due to nonspecific binding of immunotoxin to macrophages and activated lymphocytes. We hereby attempted to design an immunotoxin with unaltered efficacy and decreased toxicity. In these immunotoxins, modified diphtheria toxin (DT) acts as cytotoxic moiety and IL-2 as the targeting moiety for cancer cells that over express IL-2 receptor on their surface. IL-2 receptor has three subunits alpha, beta and gamma. Biological effect of IL2 is mediated through IL2 alpha beta gamma receptor and IL2 beta gamma receptor complexes ...
Background: IL-2 was the first cancer immunotherapy approved, producing durable responses in ∼10% of patients treated for metastatic melanoma and renal cancer. However, IL-2 has poor pharmacokinetics, is both an activator and suppressor of the immune system, and is associated with severe cardiovascular side effects of hypotension and vascular leak syndrome, limiting widespread use. NKTR-214 is a novel immunotherapeutic consisting of IL-2 conjugated at a defined region within the protein to 4-6 polyethylene glycol (PEG) chains. Once administered, PEG chains slowly release to generate active IL-2 conjugates biased towards activation of CD122, the IL-2 receptor beta subunit (IL-2Rβ), highly expressed on memory effector CD8+ T cells (CD8T). In the tumor microenvironment, NKTR-214 preferentially expands CD8T over regulatory T cells (Treg), thus tipping the balance in favor of immune activation with a CD8T/Treg ,400. In syngeneic mouse tumor models, NKTR-214 demonstrated robust single agent ...
The availability of recombinant cytokines has enabled research into cytokine biology as well as their application in a clinical setting. One aspect which is becoming clear is that the systemic injection of large doses of cytokines is associated with considerable toxicity, usually due to, or accompanied by, vascular leak syndrome. A series of cytokine fusion proteins was produced in an effort not only to reduce cytokine-associated toxicity but also to combine biological effects of cytokines that stimulate the innate immune system with those that promote an adaptive immune response. In this report is described one such fusion molecule that satisfies all of these criteria. A fusion protein combining IL-2 and IL-18 was made to produce a single molecule that would keep intact their biological properties and keep a constant molar ratio of the individual proteins. It was found that the order IL-2/IL-18 was required to maintain secretion and activity. The constructs mproIL-18/IL-2 and mIL-18/IL-2 were ...
Unfortunately, to date there are no standardized criteria for the clinical diagnosis of increased microvascular permeability, because the assessment of fluid distribution and fluid balance in septic patients is very difficult. Clearly, early diagnosis of increased microvascular permeability would be valuable, because it would allow early and specified treatment as well as the evaluation of the efficacy of therapeutic efforts. It is important to distinguish between increased microvascular permeability and other hypo-oncotic conditions leading to fluid retention, that is, caused by renal or hepatic failure. Proposed criteria for clinical assessment of the microvascular leak syndrome so far either are nonspecific or have limited bedside applicability: Microvascular leak was defined as noncardiogenic generalized edema and hemodynamic instability or more than 3 percent increase of body weight within 24 hours, combined with generalized edema. In this context, it is worth noting that calculated fluid ...
Sphingosine 1-phosphate (S1P, 1) regulates vascular barrier and lymphoid development, as well as lymphocyte egress from lymphoid organs, by activating high-affinity S1P1 receptors. We used reversible chemical probes (i) to gain mechanistic insights into S1P systems organization not accessible through genetic manipulations and (ii) to investigate their potential for therapeutic modulation. Vascular (but not airway) administration of the preferred R enantiomer of an in vivo-active chiral S1P1 receptor antagonist induced loss of capillary integrity in mouse skin and lung. In contrast, the antagonist did not affect the number of constitutive blood lymphocytes. Instead, alteration of lymphocyte trafficking and phenotype required supraphysiological elevation of S1P1 tone and was reversed by the antagonist. In vivo two-photon imaging of lymph nodes confirmed requirements for obligate agonism, and the data were consistent with the presence of a stromal barrier mechanism for gating lymphocyte egress. ...
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As a homeschooling family, much time is spent gathered around our dinner table. It is the place where we eat, yes, but it is so much more than that. Our dinner table is the place where we do school, make crafts - even messy ones, the place where my kids get to help cook different…
Blocking of monocyte migration induced by supernatant of RA SCL stimulated with TNF-α. Monocyte migration induced by supernatants of RA SCLs (RA6/1 and RA8/3)
BACKGROUND: Recombinant interleukin-2(rIL-2) therapy in metastatic melanoma is limited by toxicities, particularly vascular leak syndrome(VLS). Taurolidine potentiates the anti-neoplastic effects of IL-2 while reducing its associated endothelial cell dysfunction in experimental settings. We hypothesized that co-administration of rIL-2 with taurolidine could enhance tolerability without weakening effectiveness. METHODS: Eleven patients with progressive metastatic melanoma received high-dose rIL-2 with co-infusion of taurolidine. Patients were monitored for the development of toxicities and evidence of response. RESULTS: Ten patients tolerated twenty-nine courses of high-dose rIL-2 without dose-reduction. Most toxicities were low-grade. No patient developed VLS. Seven patients died from disease progression. Two had complete clinical and radiological responses to treatment. Two patients remain alive despite evidence of disease progression a mean of 17.5 months after diagnosing metastatic disease. ...
Purpose: : Ideally, soft contact lenses (SCLs) should be highly wettable and immune to oily and proteinaceous tear-film deposits during wear. Therefore, it is important to assess SCL wettability performance when the lens is in contact with human tear film especially the lipid layer. For the first time, we devise and evaluate an in-vitro blink-cycle cell that mimics contact-lens exposure to the human-eye environment during blinking and that permits contact-angle assessment. Methods: : An in-vitro blink-cycle cell was designed to measure contact angles of SCLs during model blink cycles. A syringe pump flows an artificial tear solution into and out of a blink-cycle cell, thereby raising and lowering the liquid level above and below the surface of the lens. The artificial tear solution contains phosphate-buffered saline (PBS), mucin, and tear-film proteins. Importantly, a model tear lipid is spread over the air/water interface to reflect exposure to meibomian lipids. One blink cycle corresponds to ...
The survey on staff satisfaction in relation to the use of SCLs was completed by 48 employees (54% of the staff), 10 doctors and 38 nurses, a difference that was not statistically significant (P=.501). When it came to the usefulness of SCLs, 75% (36/48) considered that SCLs were useful or very useful, 14.58% (7/48) felt indifferent, and 10.42% (5/48) considered them of little use or useless. Of all respondents, 68.75% (33/48) believed that SCLs had succeeded in preventing some AEs. In addition, 87.5% (42/48) of respondents did not feel that SCLs added significantly to their work burden. As for the level of overall satisfaction with SCLs, 54.16% (26/48) reported feeling satisfied or very satisfied, 31.25% (15/48) indifferent and 14.58% (7/48) dissatisfied. One hundred percent of respondents replied Yes to the question "if your child was hospitalised in the neonatology department, would you like safety checklists to be implemented to improve their safety?".. The percentage of respondents that ...
In the human body, carbon dioxide (CO2) is a metabolic waste product of aerobic metabolism. Specifically, two catabolic processes, pyruvate decarboxylation and the Krebs cycle, both of which occur in the mitochondria of cells, produce CO2. As a result of these processes, the concentration of CO2 increases proportionally to metabolic activity within tissues, leading to an increased partial pressure of carbon dioxide (Pco2). This pressure gradient drives CO2, a highly lipid-soluble molecule, out of tissues, across cell membranes, and into the blood of systemic capillaries. Once it has diffused into the capillaries, CO2 is transported to the lungs by three mechanisms. ...
Malignant gliomas represent a difficult therapeutic challenge due to the invasive nature of the tumor and limited tumoral delivery of therapeutic agents. In this study, novel nano liposome carriers composed of sulfatides were developed for the glioma targeted delivery. Firstly, sulfatides-containing liposomes (SCLs) were found to interact with glioma cells specifically. The specific interactions between sulfatides and tenascin-c (TN-C), a glioma overexpressed protein, may have an important role. Secondly, the mechanism of intracellular delivery of SCLs was studied. SCLs were found to be effectively internalized in glioma cells by both clathrin-dependent and caveolae/lipids rafts pathways. Thirdly, doxorubicin (DOX) was effectively loaded into the SCLs to form a liposomal drug, SCL-DOX. SCL-DOX could effectively accumulate in the nuclei of glioma cells that resulted in superior in vitro cytotoxicity. In a subcutaneous xenografts animal model, SCL-DOX could effectively inhibit tumor growth and ...
daflon price philippines. buy now daflon mastercard. where can i purchase daflon. cheap daflon bangkok. In edema, one of the most frequent complaints of patients, Daflon 500 mg brings about a significant reduction in leg circumference, thanks to its capacity to inhibit inflammatory reactions and to decrease capillary hyperpermeability.. half price Should We Focus on Novel Risk Markers and Screening Tests to Better Predict and Prevent Cardiovascular Disease?. head phones daflon 500 pioneer. order daflon maine. buy online 500mg. cheap legitimate daflon in Hialeah. This is the first article I have read that offers to shrink the size of the fibroid.. daflon medication cost. average cost of without insurance. PLEASE TELL ME AN ACCURATE MEDICINE TO RELIEF FROM THIS DISEASE.. buy brand daflon cheap. buy daflon treat edema,venous leg ulcer,venous trophic disorders,acute hemorrhoidal attack thailand. Acetaminophen hepatotoxicity: the first 35 years.. therapy daflon tablets therapy daflon tablets kaufne ...
Myocarditis is a common cardiac disease. It appears to be a major cause of sudden death, and may progress to chronic dilated cardiomyopathy. From the clinical point of view, there are several challenges unique to the management of patients with myocarditis. The first challenge is to establish the diagnosis of myocarditis, which is usually based on clinical, pathological, or a combination of diagnostic criteria. The second challenge is to follow the disease activity to identify patients who may be at risk of chronic dilated cardiomyopathy development, which seems to be associated with ongoing myocardial inflammation (1) and viral persistence (2).. Cardiac magnetic resonance (CMR) has recently emerged as a noninvasive tool to diagnose myocarditis (3-6), as well as to follow its course in living patients (3,7-9). Three features potentially associated with acute myocardial inflammation may be visualized by CMR: 1) tissue edema, which may result in an elevated T2 signal; 2) capillary leakage, which ...
Whos the biggest recording star to come out of American Idol? I really think we should call it a tie. Carrie Underwood has sold more albums, but Kelly Clarkson has sold more individual songs. Just this week, Clarksons #1 smash Stronger (What Doesnt Kill You) pulled ahead of
On Wednesday, August 20, the VLS will have the 2015 AIChE President-Elect Candidates, Greg Stephanopoulos and Tom Hanley, discuss their vision for AIChE.
Primary graft dysfunction (PGD) is the most common cause of early morbidity and mortality following lung transplant and is characterized by acute lung injury and capillary leak leading to an increase in extravascular lung water index (ELWI) and impaired graft function. PGD has many features in common with acute respiratory distress syndrome (ARDS). PGD may be life-threatening and can also lead to impaired long term lung function. In ARDS, a restrictive fluid strategy has been associated with an improvement in lung function and outcomes. Accurate methods of evaluating, quantifying and guiding the hemodynamic / fluid management and limiting the extent of ELWI that accumulates in the setting of PGD are lacking. Using transpulmonary thermodilution to estimate ELWI and the pulmonary permeability index (PPI) represents a novel approach to fluid management, which has been used in patients with ARDS, but to date not in the transplant setting. To determine if these measurements may better guide the ...
We experimentally demonstrate the realization of a parity-time (PT) symmetry breaking in optically coupled semiconductor lasers (SCLs). The two SCLs are identical except for a detuning between their optical emission frequencies. This detuning is analogous to the gain-loss parameter found in optical PT systems. To model the coupled SCLs, we employ the standard rate equations describing the electric field and carrier inversion of each SCL, and show that, under certain conditions, the rate equations reduce to the canonical, two-site PT- symmetric model. This model captures the global behavior of the laser intensity as the system parameters are varied. Overall, we find that this bulk system (coupled SCLs) provides an excellent test-bed to probe the characteristics of PT-breaking transitions, including the effects of time delay ...
Clinical records from 166 patients with symptomatic CIEs and known EW status were reviewed, adjudicated and analyzed. Cases used ,50 SCL brands and ,10 LCP brands. Age, increasing CL Power, EW, reusable SCLs, silicone hydrogels and student status were significant univariate factors. In the multivariate analysis, age (1.05X/year; 1.03, 1.06 95% C.I.), EW (4.18X, 2.44, 7.15) and Reusable SCL (6.27X, 1.88, 20.97) were significant. Among daily wearers, the only significant factors were age (1.05X/year, 1.03, 1.08), reusable SCLs (11.48X, 1.41, 93.49) and silicone hydrogel SCLs (1.94X, 1.03, 3.66). Without DD, age (1.04X/year, 1.02, 1.06), EW (4.42X, 2.53, 7.71) and silicone hydrogel SCLs (1.80X, 1.01, 3.22) were significantly associated with CIEs. ...
A patient had fatal hypovolemic shock and edema. As in previously reported cases, the mechanism of shock appears to be loss of protein and fluid from the vascul
High-dose therapy in conjunction with autologous stem cell rescue can achieve a minimal disease state and improve disease-free survival for patients with myeloma and other hematologic malignancies. However, relapses are common due to the lack of an effective antitumor immune response to eliminate residual disease. In principle, the period following high-dose therapy should be conducive to the application of immunotherapy given the low tumor burden and the potential reduction in Treg populations. Unfortunately, following standard autologous transplants, the immune system is typically characterized by immune cell depletion and impaired immune cell function, which may persist for up to 4 to 10 years (32, 33).. In a previous randomized study, we found that a single infusion of ∼8 × 109 costimulated autologous T cells at day +12 after transplant accelerated the numerical and functional recovery of both CD4+ and CD8+ T cells and could provide help for vaccination during the early posttransplant ...
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CLINICAL FINDINGS: 3 horses had a history of lameness for , 6 months; specific duration was unknown for 1 horse. On initial evaluation, grade 3 to 4 (on a scale from 1 to 5) hind limb lameness was present in all 4 horses. Radiography of the stifle joint of the affected limb revealed medial femoral condyle subchondral lucencies or subchondral cystic lesions (SCLs) in all 4 horses, medial femorotibial osteoarthritis in 3 horses, and medial tibial condyle SCLs in 3 horses ...
Background: Trauma is a major cause of death and disability. Adverse events, such as prolonged prehospital time, hypoxia, hypotension and/or hyperventilation have been reported to correlate to poor outcome.. Adequate cortisol levels are essential for survival after major trauma. In hypotensive critically ill patients, lack of sufficient amount of cortisol can be suspected, and a concept of critical illness related corticosteroid insufficiency has been proposed. Corticosteroid therapy has many adverse effects in critically ill patients and should only be given if life-saving. Correct measurement of serum cortisol levels is important but difficult in critically ill patients with capillary leakage. Estimation of the free and biologically active cortisol is preferable. In serum less than 10% of cortisol is free and biologically active and not possible to measure with routine laboratory methods. Salivary cortisol can be used as a surrogate for free cortisol, but salivary production is reduced in ...
SCAs $325/hour attorney blocked the release of the 2018 update of the 2017 SCA employee compensation table that was already in the public domain. SCA homeowners had to foot the bill for Clarkson to write "legal letters", in SCAs name, in January to threaten legal action against me if I told KTNV what the GMs pay was (even though they already knew) and against KTNV if they ran the story.. There was no Board action authorizing this threat of legal action - unless, of course, they took the action in a secret meeting.. And, by the way, NRS 116.31088 requires a VOTE of the membership, before SCA can file a civil action. But no big deal.. This is a provision of the law that Adam Clarkson made disappear when the SCA Board filed a civil action to evict the Foundation Assisting Seniors. Im sure Adam Clarksons convoluted reading of the law will come up with some magical way that allows the GM to use him to threaten litigation, against anybody or everybody, in SCAs name, and on SCA owners ...
The 3 Leading Causes of Column Leaks Among some chromatographers, capillary connections using press fit connectors have a reputation for leaking. Where there wa
Background: Trauma is a major cause of death and disability. Adverse events, such as prolonged prehospital time, hypoxia, hypotension and/or hyperventilation have been reported to correlate to poor outcome.. Adequate cortisol levels are essential for survival after major trauma. In hypotensive critically ill patients, lack of sufficient amount of cortisol can be suspected, and a concept of critical illness related corticosteroid insufficiency has been proposed. Corticosteroid therapy has many adverse effects in critically ill patients and should only be given if life-saving. Correct measurement of serum cortisol levels is important but difficult in critically ill patients with capillary leakage. Estimation of the free and biologically active cortisol is preferable. In serum less than 10% of cortisol is free and biologically active and not possible to measure with routine laboratory methods. Salivary cortisol can be used as a surrogate for free cortisol, but salivary production is reduced in ...
A sequela of PPH is hypovolemic shock. Under normal circumstances, postpartal clients are able to withstand blood loss during the postpartum period as a result of increased blood volume during pregnancy. However, in the presence of a PPH, hypovolemic shock can occur and cause severe organ damage and even death if untreated. Often tachycardia is the first sign of hypovolemic shock. The blood pressure usually decreases and the respiratory rate increases. The skin becomes cool and pale initially and then cold and clammy. Clients may also become anxious, agitated, and restless as blood loss starts to affect the brain. Hypovolemic shock can be stopped by stopping blood loss. These clients will also require oxygen (usually 8-10 mL via face mask), IV fluids, and possibly blood products. This is a very serious situation and nurses must be prepared to assist in this life-threatening emergency ...
Inhibitory effects of sasanquasaponin on over-expression of ICAM-1 and on enhancement of capillary permeability induced by burns in rats. - Qiren Huang, Lijian Shao, Ming He, Heping Chen, Dan Liu, Yongming Luo, Yucheng Dai
Did most of the top 12 boys choke, or are our expectations just too high? After suffering through disappointing performances from the top 12 girls on American Idol, we finally got a chance to watch the guys take the stage last night, and the results were... slightly less disappointing. Though there were a few standout performances (big ups to Casey James and Joe Muñoz) we couldnt help but long for the boys of season eight: Where were the Adam Lamberts? The Kris Allens? Wed even settle for another Matt Giraud! Todrick Hall, 24, set the tone for the evening by butchering Kelly Clarksons Since U Been Gone with an awkward R&B rendition that just didnt work. Even 20-year-old Tyler Grady (who we love) put on a lackluster performance of The Guess Whos American Woman. The judges agreed his 70s rocker vibe is too cliché and it feels forced. Tyler told Ryan Seacrest he may have to take a trip to the mall to change his image - and we cant wait to see to see what he comes up with! Read more & tell
Your goal is to find and repair a leak prior to the evacuation and charge process, eliminating the costly rework and the compromised quality that comes from repairing a leak in a charged unit. LeakProof, ECIMOS Integrity and Helium Leak Testing Systems, are located immediately after the assembly and brazing of the refrigeration circuit. These helium leak testing systems may also be located in coil sub-assembly areas. LeakProofs sequence of operation is computer-controlled, its parameters are model specific, and it satisfies the requirements of "UL". Integrate it with ECIMOS Brazer Performance Tracking System to qualify or disqualify brazers.. Powered by ECIMOS manufacturing operating system, LeakProof is able to keep track of the following parameters: ...
The hypothesis that opiate receptors are involved in the cardiovascular pathophysiology of hypovolemic shock was tested by using the opiate receptor antagonist naloxone. Naloxone increased mean arterial pressure, cardiac output, stroke volume and left ventricular dP/dtmax in a canine hemorrhagic shock model. Naloxone treatment also prolonged survival time. All these responses were dose-dependent and were independent of blood reinfusion. It is concluded that endorphins activated by stress act on opiate receptors to bring about some of the cardiovascular abnormalities in hypovolemic shock. ...
The objective of this study was to assess the impact of CAGB surgery-induced alterations in ANG1, ANG2 and TIE2 levels on post-surgical SIRS and to evaluate potential mechanisms inducing capillary leakage. Our results indicate that CABG induced profound changes in the ANG2/ANG1 balance with loss of the barrier-protective ANG1 and an increase in the barrier-disruptive ANG2 contents in the patients serum. This imbalance was observed in adult patients with systemic pro-inflammatory response characterized by elevated IL-6 levels. The molecular changes correlated with clinical surrogate parameters of an impaired endothelial barrier function, such as fluid balance, application of vasoconstrictors, and prolonged ventilation.. In healthy individuals, constitutive expression of ANG1 results in much higher serum concentrations than ANG2, which is mainly secreted upon endothelial stimulation; therefore, an increased ratio between ANG2 and ANG1 (in healthy adults a numerical value below 1) serves as marker ...
Hypoproteinemia: A condition in which total serum protein level is below the normal range. Hypoproteinemia can be caused by protein malabsorption in the gastrointestinal tract, EDEMA, or PROTEINURIA.
New Jersey Devil David Clarkson will be in a battle! Only instead of battling Darren McCarty or Chris Neil, he will be teaming up with seven-time Tour de France Champion Lance Armstrong in a battle against Cancer...
A condition in which total serum protein level is below the normal range. Hypoproteinemia can be caused by protein malabsorption in the gastrointestinal tract, edema, or proteinuria.
Editors note: This is a weekly digest of stories were following - trends, news you can use and provocative parenting reads. Do you have a good read for us? Write [email protected] 1. In a provocative Mothers Day campaign designed to remind the world of the large number of women who die in pregnancy and childbirth, model Christy Turlington is asking mothers to "disappear" on Mothers Day.. 2. A must-watch: An inspiring music video made by a young leukemia patient at Seattle Childrens -- starring his fellow patients -- to Kelly Clarksons "Stronger.". 3. Pioneering childrens author Maurice Sendak -- who "wrenched the picture book out of the safe, sanitized world of the nursery" -- dies at 83.. 4. Washington State opens the emergency cash fund to help fight the growing whooping cough epidemic; were on track for as many as 3,000 cases in 2012.. ...
When a tourniquet is left on too long, it can lead to hemoconcentration, which is a pooling of blood at the venipuncture site, according to MediaLab. A tourniquet is used to increase venous pressure...
For decades, California utilities have logged, but not repaired, thousands of pinprick leaks in pipelines criss-crossing the state.
1 Answer - Posted in: remedy, herbal, goshajinkigan - Answer: Im no doc and dont know how old u r or if youre make it female. Either ...
C. Dautermann, L. Schürer, R. Härtl, S. Berger, R. Murr, K. Meßmer, A. Baethmann; A277 TREATMENT OF HYPOVOLEMIC SHOCK WITH HYPERTONIC - HYPERONCOTIC SOLUTIONS: EFFECTS ON REGIONAL CEREBRAL BLOOD-FLOW. Anesthesiology 1990;73(3A):NA. doi: https://doi.org/.. Download citation file:. ...
Nearly every college and university offers a major in Chemistry. Some prepare secondary school teachers, others researchers. You will discover that Clarksons program in Chemistry is special and exciting. The unique position of Clarkson University is the major reason we feel so strongly about our Chemistry program. Clarkson is a relatively small institution, about 2,800 students. Yet, we are one of the major research institutions in the Northeast. Many of our professors are internationally recognized. Just as important as our facultys scientific credentials, however, is the fact that they care about teaching. They give personal attention to each student.. Our classes are small, and even the most senior faculty teach undergraduate courses. You will have every opportunity not only to excel, but to excel in an environment of mentorship and support. The nature of our Chemistry curriculum is also unique. Chemistry at Clarkson is more than theory and classroom study. We "do" Chemistry. The applied ...
Who Knew" is a song by American singer Pink from her fourth studio album Im Not Dead (2006). Written by Pink, Max Martin and Lukasz "Dr. Luke" Gottwald, the song was originally released on May 18, 2006, by the LaFace label to radio as the albums second single, but was only a moderately success. After the success of "U + Ur Hand", the song was later successfully re-released in June 2007 as the albums fourth single in the United States. Musically, "Who Knew" is a pop song. Lyrically, it is regarding the loss of a good friend of hers. Upon its release, "Who Knew" was well received by music critics, who acclaimed it as a solid song on the album and lauded the lyrical content. It faced comparisons for having similarities with Kelly Clarksons 2004 single "Since U Been Gone", also written by Martin and Dr. Luke. The song was commercially successful worldwide, where it peaked in the top spot in countries including Australia, Czech Republic, Germany, Hungary, and component charts in the United ...
Affiliation:School of Medicine Plastic Surgery,Fujita Health University,Instructor,医学部,助手, Research Field:Orthopaedic surgery, Keywords:hypovolemic shock,失血性ショック,blood transfusion,微小循環,脱血,輸血,挙睾筋,dehematise,cremaster muscle,microcirculation, # of Research Projects:1, # of Research Products:0
For kidney patients, prednisone is not uncommon. It is often used to block inflammatory response in the kidneys and decrease the permeability of capillaries so as to stop protein leakage. But prednisone has many side effects if used for lon
Well Water Supply Piping Leak Diagnosis & Repair - Characteristics of a leak in the pipe between well and building Effects of well piping leaks, diagnosis, effects, remedy A simple guide to the types of leaks that occur in water pipes, drain pipes, & plumbing fixtures Causes of well piping leaks The Old House Repair
Take a leak definition, an unintended hole, crack, or the like, through which liquid, gas, light, etc., enters or escapes: a leak in the roof. See more.
lēk) v. leaked, leak·ing, leaks. v.intr. 1. To permit the escape, entry, or passage of something through a breach or flaw: rusted pipes that were beginning to ...
Could you tell me what is the best way to find a leak?Water is below the light and I got a plug in the drain.Im still losing water,I checked all around the seams no tears Im lost for answers Ive called all the pool companies and get no where can you help ...
Skrelp, Fennekin, Squirtle, Spritzee, Honedge, Meowstic (Not sure this is even on-topic, so I can delete this if need be) Also, has it been confirmed if the...
The spread of Dengue virus infection is reaching pandemic proportions. Dengue is usually dreaded for causing shock due to capillary leakage. However the clinical spectrum of dengue is vast and the newly incorporated expanded dengue syndrome introduces a wide range of presentations that are rarely observed and appreciated but nevertheless have the potential to cause significant morbidity and even mortality. Cardiac involvement in dengue is one such example. A 26 year old South-Asian female presented in a state of haemodynamic shock with a history of fever and use of non-steroidal anti inflammatory drugs. Dengue was suspected clinically and later confirmed. Following stabilization and while still in the febrile phase the patient developed bradycardia with dynamic electrocardiogram changes which evolved into complete heart block. However there was no circulatory compromise. Clinical picture was further complicated by the development of dengue haemorhaghic fever and cautious fluid resuscitation was carried
The treatment and treatment of nephrotic syndrome, first of all we should understand is that the treatment stage of the disease should be better care, as we have increased awareness of the disease of nephrotic syndrome, patients will appear
Looking for interstitial space? Find out information about interstitial space. A crystal defect in which an atom occupies a position between the regular lattice positions of a crystal. Of, pertaining to, or situated in a space between... Explanation of interstitial space
Hypoalbuminemia, causes of Hypoalbuminemia, common and rare causes, symptom information, types, related symptoms, diagnosis, misdiagnosis of Hypoalbuminemia, tests, and more information.
Hello Folks, I have not checked in for a while so thought it was time. My situation in a nutshell is that I have been living with CSF ear leaks (both ears) following a head injury five years ago now. The leaks are apparently small and usually are more like a seep than a leak. Anyway, right after my injuries they detected the leaking but apparently the leaks partially healed and although my symptoms continue, they cannot detect the leaks. I occassionally will get a drop or two of fluid
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In the audiovisual installations by the European label AntiVJ, interstitial space is presented as a series of dynamic immaterial ruptures. Large-scale installations such as Murcof+AntiVJ (2009) and 3Destruct (2007) visually break the confines of built architecture and autonomous spatial folds, through the projection of light onto invisible semi-transparent screens arranged in space. In this way, instead of being limited to the perimeter of the built space, the space between the built surfaces of architecture is utilised. As spectators walk through 3Destruct, they become disoriented in such a "non-linear universe", the form of which, oscillates rapidly between weightless planar layerings and linear mazes of changing colour, opacity and density.. [10] In Murcof+AntiVJ, a rain of shattered and colliding geometries, rapidly contracted and expanded spatialities, emerges through the projection of digital visualisations onto a similar type of screens. In both audiovisual installations, space is ...
Learn more about UVMs 3+2 Program with VLS. This program is great for the exceptionally focused and motivated student whos ready to make an early commitment to law. Save money and time by completing your undergrad in 3 years and an accelerated JD in 2 years. VLS will be there to talk more about the program on their end, and the AJD and VLS experience ...
Water leaks from the bottom front under the bucket. Bucket does NOT leak. Attached a piece of tubing from the - Haier AHD50 Dehumidifier question
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I just cannot seem to get it to hold past day #2. I dont know what it is, but it seems every 2 days it starts leaking and we have to rush to change it. Her stoma is very odd shaped. Longer on one side than the other, and her belly is also more protruded on the tip/right side than it is on the left, so I attempted using the paste this time to hopefully get a few extra days in. (For those who are curious, we are using the Holister brand New Image wafers). It always seems to leak in the SAME spot, so I am hoping this works! The only good thing about changing it every 2 days is that I can make her shower with it all off and give her skin a break ...
Light leaks are probably one of the main reasons I enjoy analog photography so much. Theyre like little perfect imperfections that add a whole new feel to the image - makes the picture appear a little softer and dreamier.
Stings from bees or wasps produce a variety of clinical manifestations [1-7]. In cases of corneal bee sting discussed in the literature, corneal complications have been reported most frequently [2-4]. In all these cases, the corneal edema regressed and infiltrates resulted in a corneal scar 4 to 6 weeks after removal of the stinger and the initiation of treatment. Corneal edema has been explained by cell death caused by activation of the complement cascade by proteins in the bee venom, leading to the production of anaphylotoxins and chemotactic factors [1, 3]. Bee venom is a complex toxin having various impacts and components. It contains two types of biogenic amines: non-enzymatic polypeptide toxins (melittin, apamin, mast cell degranulating peptide) and enzymes (phospholipase A, phospholipase B, hyaluronidase). Ocular inflammation increases capillary protein permeability allowing greater leakage of proteins into the vitreous space.. The difference of wasp sting effects depends on the type of ...
Polypeptides, compositions, and methods for treating shock are described. A isolated polypeptide, Deltorphin-E, can be administered without concomitant fluid resuscitation, before, concurrently with,
Increased microvascular permeability to plasma proteins and neutrophil emigration are hallmarks of innate immunity and key features of numerous inflammatory disorders. Although neutrophils can promote microvascular leakage, the impact of vascular permeability on neutrophil trafficking is unknown. Here, through the application of confocal intravital microscopy, we report that vascular permeability-enhancing stimuli caused a significant frequency of neutrophil reverse transendothelial cell migration (rTEM). Furthermore, mice with a selective defect in microvascular permeability enhancement (VEC-Y685F-ki) showed reduced incidence of neutrophil rTEM. Mechanistically, elevated vascular leakage promoted movement of interstitial chemokines into the bloodstream, a response that supported abluminal-to-luminal neutrophil TEM. Through development of an in vivo cell labeling method we provide direct evidence for the systemic dissemination of rTEM neutrophils, and showed them to exhibit an activated ...
It depends on the degree of damage or cut. Certainly our body will compensate for that blood loss. More blood is lost if the cut is big. The body compensates for the gradual decrease in blood volume. The heart rate increases since the heart needs to pump much more just to maintain the normal blood volume and so the BP also increases. Now if the situation wont be given an attention, the blood volume decreases significantly and that could possibly lead to a more life threatening condition which is hypovolemic shock. When BP is obtained, it will be read below the normal level since the compensatory mechanism is no longer able to sustain the necessary blood volume of the body ...
Small aortas were documented by CT in six patients, 16-34 years old. The diameter of these aortas measured at the level of 1 cm below the orifice of the superior mesenteric artery ranged from 10 to 12 mm, much smaller than the mean of 17 mm obtained from 20 subjects, 16-20 years old. Such small aortas are usually produced by vasoconstriction as a compensatory response to hypovolemic shock. © 1990 Raven Press, Ltd., New York ...
Pre-treatment with ampicillin (200 mg kg(-1) day(-1), p.o.), metronidazole (200 mg kg(-1) day(-1), p.o.), or polymixin B (15 mg kg(-1) day(-1), s.c.), inhibited indomethacin-induced lesion formation, reduced microvascular leakage and prevented the expression of iNOS activity ...
I ended up with the data as seen to the left. Each "Heapshot" iteration represents opening, then closing, an untitled window with no data in it.. The "Heap Growth" and "Still Alive" columns provide a summation of all of the objects in that heapshot that still exist in all subsequent samplings of the heap. That is, in Heapshot 3, there were 36.08K of allocations spread across 260 allocation events that continued to exist throughout the rest of the run.. Specifically: the values in those columns represent permanent heap growth.. When creating, then closing, an untitled document there should be, ideally, no heap growth. That there is ~35K per document of permanent heap growth indicates that a leak does exist (regardless of what leaks said above).. Note that as you continue to iterate, you might see the values of previous Heapshot samples decrease. That is because objects allocated in that sample - at that heap mark - have been released. That is, every single object listed in that table - all ...
Hypovolemic (Small-Volume) Shock. That is a prevalent kind that transpires when blood or plasma is lost in these kinds of portions that the remaining blood are not able to fill the circulatory system In spite of constriction of the blood vessels. The blood loss could possibly be exterior, as when a vessel is severed by an injuries, or maybe the blood might be "dropped" into spaces In the body in which it can be now not accessible on the circulatory system, as in serious gastrointestinal bleeding from ulcers, fractures of enormous bones with hemorrhage into bordering tissues, or major burns that appeal to massive portions of blood fluids to the burn prp hair growth up web page outside blood vessels and capillaries. The treatment of hypovolemic shock involves replacement of the misplaced volume ...
Acute respiratory distress syndrome (ARDS) is a life threatening respiratory failure due to lung injury from a variety of precipitants. Pathologically ARDS is characterised by diffuse alveolar damage, alveolar capillary leakage, and protein rich pulmonary oedema leading to the clinical manifestation of poor lung compliance, severe hypoxaemia, and bilateral infiltrates on chest radiograph. Several aetiological factors associated with the development of ARDS are identified with sepsis, pneumonia, and trauma with multiple transfusions accounting for most cases. Despite the absence of a robust diagnostic definition, extensive epidemiological investigations suggest ARDS remains a significant health burden with substantial morbidity and mortality. Improvements in outcome following ARDS over the past decade are in part due to improved strategies of mechanical ventilation and advanced support of other failing organs. Optimal treatment involves judicious fluid management, protective lung ventilation with ...
... that it may cause posterior reversible encephalopathy syndrome, that it may cause capillary leak syndrome, that it may cause ... ISBN 0-470-09254-8. Siddall, E; Khatri, M; Radhakrishnan, J (16 March 2017). "Capillary leak syndrome: etiologies, ... severe lung conditions like pulmonary edema, pneumonia, and adult respiratory distress syndrome, and that it may harm sperm. ...
These toxicities include neuropathic pain, capillary leak syndrome, and hypersensitivity reaction. Anti-GD2 antibodies have ...
Systemic Capillary Leak Syndrome website on RareShare.org Bhanoo, Sindya N. "Sharing the Pain." The Washington Post. 10 ... Since late 2005, Porzecanski has struggled with an exceedingly rare illness, Systemic Capillary Leak Syndrome (SCLS), which ... He also persuaded the National Institutes of Health to carry out basic biomedical research on this syndrome. In early 2009, ...
ISBN 978-0-8089-2402-9 Semb K A, Aamdal S, Oian P. "Capillary protein leak syndrome appears to explain fluid retention in ... cause anasarca through a poorly understood capillary leak syndrome. In Hb Barts, the high oxygen affinity results in poor ...
Capillary leak syndrome also leads to abnormally high hematocrit counts, because of the episodic leakage of plasma out of the ... In order to maintain pressure, the capillaries branch off to a web of vessels that carry blood into the venules. Through this ... As blood flows through the arterioles, red cells will act a feed hematocrit (Hf), while in the capillaries a tube hematocrit ( ... The packed cell volume (PCV) can be determined by centrifuging heparinized blood in a capillary tube (also known as a ...
While some reports were positive, others have reported capillary leak syndrome suspected to be the result of overly rapid ... POEMS syndrome (also termed osteosclerotic myeloma, Crow-Fukase syndrome, Takatsuki disease, or PEP syndrome) is a rare ... Some features have been observed in patients with POEMS syndrome but are not yet certain to form part of the syndrome itself. ... afflicted by POEMS syndrome. The diagnosis of POEMS syndrome is based on meeting its two mandatory criteria, meeting at least ...
Several causes have been speculated, including a capillary leak syndrome from cytokine release from the differentiating myeloid ... "Differentiation (retinoic acid) syndrome". Retrieved 10 March 2011. Tallman MS (February 2002). "Retinoic acid syndrome: a ... and to an increasing use of the term differentiation syndrome to signify this APML treatment complication. The syndrome is ... Retinoic acid syndrome (RAS) is a potentially life-threatening complication observed in patients with acute promyelocytic ...
... but it is unrelated to capillary leak syndrome (which may cause similar swelling episodes) and eosinophilia-myalgia syndrome ( ... Gleich's syndrome is not a form of the idiopathic hypereosinophilic syndrome in that there is little or no evidence that it ... Gleich syndrome has a good prognosis. Attack severity may improve with steroid treatment. Gleich GJ, Schroeter AL, Marcoux JP, ... Gleich's syndrome or episodic angioedema with eosinophilia is a rare disease in which the body swells up episodically ( ...
Corona-Fragoso syndrome Cantu-Sanchez-Corona-Garcia syndrome Cantu-Sanchez-Corona-Hernandes syndrome Capillary leak syndrome ... CCA syndrome Ccge syndrome CCHS CDG syndrome type 1A CDG syndrome type 1B CDG syndrome type 1C CDG syndrome type 2 CDG syndrome ... syndrome COFS syndrome Cogan-Reese syndrome Cogan syndrome Cohen-Hayden syndrome Cohen-Lockood-Wyborney syndrome Cohen syndrome ... syndrome type 1 Cockayne syndrome type 2 Cockayne syndrome type 3 Cockayne's syndrome Codas syndrome Codesette syndrome Coeliac ...
Capillary leak syndrome a rare medical condition where the number and size of the pores in the capillaries are increased which ...
... and capillary leak syndrome. Other common adverse effects include retention or urine for weeks to months after receiving the ...
Hemolysis Capillary leak syndrome Clotting of blood in the circuit - can block the circuit (particularly the oxygenator) or ... 1.5% of patients that undergo CPB are at risk of developing Acute Respiratory Distress Syndrome. As a consequence, CPB is only ... CPB is not benign and there are a number of associated problems: Postperfusion syndrome (also known as "pumphead") ...
... persistent apyrexia and profound capillary leak syndrome (see entry for Clostridium novyi alpha-toxin for details of mechanism ... Severe toxic shock syndrome among previously healthy persons has been described in a small number of C. sordellii cases, most ... Pregnancy-associated infections - Toxic Shock Syndrome Also associated with a pediatric case where patient presented with a ...
Damage to the endothelial layer of blood vessels caused by these inflammatory mediators can lead to capillary leak syndrome, ... have also been implicated with Guillain-Barré syndrome and a variant of Guillain-Barré called Miller-Fisher syndrome. ... Waterhouse-Friderichsen syndrome, and meningitis. Bruce Beutler was awarded a portion of the 2011 Nobel Prize in Physiology or ... which is likely to develop on the basis of the small bowel bacterial overgrowth syndrome and an increased intestinal ...
Cytopenia, a decrease in blood cell count Capillary leak syndrome, another cause of hemoconcentration "absolute polycythemia" ... A specific type of relative polycythemia is Gaisböck syndrome. In this syndrome, primarily occurring in obese men, hypertension ... Stefanini, Mario; Urbas, John V.; Urbas, John E. (July 1978). "Gaisböck's syndrome: its hematologic, biochemical and hormonal ... a so-called myeloproliferative syndrome), or it may be a reaction to chronically low oxygen levels or, rarely, a malignancy. ...
... such as capillary leak syndrome, breathing problems, serious infections, seizures, allergic reactions, heart problems or a ... "Low Dose Interleukin-2 in Patients With Stable Ischaemic Heart Disease and Acute Coronary Syndromes (LILACS)" at ClinicalTrials ...
Muckle-Wells syndrome Familial Mediterranean fever Systemic capillary leak syndrome Physical urticarias List of cutaneous ... There are several distinct urticarial syndromes including: ...
Systemic capillary leak syndrome (SCLS, or Clarkson's disease), or primary capillary leak syndrome, is a rare, grave and ... can also cause capillary leaks. These conditions and factors are sources of secondary capillary leak syndrome. ... Capillary leak syndrome is characterized by the escape of blood plasma through capillary walls, from the blood circulatory ... engraftment syndrome, hemophagocytic lymphohistiocytosis, the ovarian hyperstimulation syndrome, viral hemorrhagic fevers, and ...
Cantú syndrome Capgras delusion Capgras Syndome Capillary leak syndrome Caplan's syndrome Carcinoid syndrome Cardiac syndrome X ... syndrome Wende-Bauckus syndrome Werner syndrome Wernicke-Korsakoff syndrome West syndrome Westerhof syndrome Wet lung syndrome ... syndrome Lynch Syndrome Lyngstadaas syndrome Löffler's syndrome Löfgren syndrome M74 syndrome Macrocephaly-capillary ... syndrome Hero syndrome Heyde's syndrome High-rise syndrome HIV/AIDS Holiday heart syndrome Holt-Oram syndrome Hopkins syndrome ...
... causing the capillaries in the retina to dilate and leak fluid into the retina. This is less common today with modern lens ... The syndrome is named in honor of S. Rodman Irvine and J. Donald M. Gass. The incidence is more common in older types of ... Irvine-Gass syndrome, pseudophakic cystoid macular edema or postcataract CME is one of the most common causes of visual loss ... Kiernan, Daniel F.; Hariprasad, Seenu M. (1 November 2013). "Controversies in the management of Irvine-Gass syndrome". ...
Following administration of this form of doxorubicin, small amounts of the drug can leak from capillaries in the palms of the ... In clinical testing at 50 mg/m2 dosing every 4 weeks, half of people developed hand-foot syndrome. The rate of this side effect ... and therefore does not result in the same rate of hand-foot syndrome. The minimization of this side effect may allow for one- ... more commonly known as hand-foot syndrome. ...
... causing the capillaries in the retina to dilate and leak fluid into the retina. Less common today with modern lens replacement ... pseudophakia' means 'replacement lens') also known as Irvine-Gass syndrome The surgery involved sometimes irritates the retina ... is similarly caused by leaking macular capillaries. DME is the most common cause of visual loss in both proliferative, and non- ... Blockage of a vein in the retina can cause engorgement of the other retinal veins causing them to leak fluid under or into the ...
... of fluid out of the capillary beds into the interstitial space in the entire body with a profound amount of this fluid leaking ... The underlying cause of the disease process is capillary permeability caused by the systemic inflammatory response syndrome ( ... the syndrome has now progressed to the end stage of the highly fatal process termed abdominal compartment syndrome. These ... causing multiple organ dysfunction syndrome and death. Abdominal compartment syndrome occurs when tissue fluid within the ...
Pulmonary hemorrhage, inflammation and damage to capillaries in the lung resulting in blood leaking into the alveoli. This may ... Other pathogens such as viruses and fungi can cause pneumonia for example severe acute respiratory syndrome and pneumocystis ... Pulmonary edema, leakage of fluid from capillaries of the lung into the alveoli (or air spaces). It is usually due to ... Pulmonary hemorrhage can be due to auto-immune disorders such as granulomatosis with polyangiitis and Goodpasture's syndrome. ...
... finally a wheal forms at the site as fluid leaks under the skin from surrounding capillaries. CUS has been categorized as an ... PMA can cause Contact Urticaria Syndrome (CUS). Contact urticaria refers to a wheal-and-flare response occurring on the ... Maibach, H. I.; Johnson, H. L. (1975). "Contact Urticaria Syndrome: Contact Urticaria to Diethyltoluamide (Immediate-Type ... Torresani, Claudio; Caprari, Elisabetta; Manara, Gian Carlo (1993). "Contact urticaria syndrome due to phyenylmercuric acetate ...
Reflex cold urticaria Schnitzler syndrome Secondary cold contact urticaria Solar urticaria Systemic capillary leak syndrome ... Turner syndrome Ulnar-mammary syndrome Van Der Woude syndrome Von Hippel-Lindau syndrome Watson syndrome Werner syndrome (adult ... Freeman-Sheldon syndrome, Windmill-Vane-Hand syndrome) Wilson-Turner syndrome Wolf-Hirschhorn syndrome (4p- syndrome) X-linked ... Rombo syndrome Rothmund-Thomson syndrome (poikiloderma congenitale) Rud syndrome Say syndrome Scalp-ear-nipple syndrome (Finlay ...
In the acute phase of ALI, there is increased permeability of this barrier and protein rich fluid leaks out of the capillaries ... Morrison RJ, Bidani A. (2002) Acute respiratory distress syndrome epidemiology and pathophysiology. Chest Surg Clin N Am. 12: ... A recent chlorine gas leak in Pune, India, landed 20 individuals in the hospital. Though that was an accidental exposure, ... The direct toxicity to the cells leads to an increase in capillary permeability. Furthermore, when phosgene hydrolyzes it forms ...
Therefore they bleed, leak protein, and slow the flow of blood through the body. As a result, some organs and tissues do not ... Coronary small vessel disease is a type of coronary heart disease (CHD) that affects the arterioles and capillaries of the ... Coronary small vessel disease is also known as cardiac syndrome X, microvascular dysfunction, non-obstructive coronary disease ... and capillaries of the brain. Age-related and hypertension-related small vessel diseases and cerebral amyloid angiopathy are ...
Systemic capillary leak syndrome is a rare disorder characterized by recurrent flares of massive leakage of plasma and other ... The systemic capillary leak syndrome: A case series of 28 patients from a European registry. Annals of Internal Medicine 2011; ... Systemic capillary leak syndrome may be triggered by an upper respiratory tract infection. Signs and symptoms of systemic ... Idiopathic systemic capillary leak syndrome (Clarksons disease): The Mayo Clinic Experience. Mayo Clinic Proceedings. 2010;85: ...
Systemic capillary leak syndrome with monoclonal IgG and complement alterations. A case report on an episodic syndrome LOFDAHL ... Systemic Capillary Leak Syndrome * * Kawabe Shotetsu KAWABE Shotetsu * the Department of Internal Medicine, Nagaoka Red Cross ... Systemic capillary leak syndrome and monoclonal IgG gammopathy; studies in a sixth patient and a review of the literature ... Capillary leak syndrome associated with elevated IL-2 serum levels after allogeneic bone marrow transplantation FUNKE I. ...
Systemic capillary leak syndrome (SCLS, or Clarksons disease), or primary capillary leak syndrome, is a rare, grave and ... can also cause capillary leaks. These conditions and factors are sources of secondary capillary leak syndrome. ... Capillary leak syndrome is characterized by the escape of blood plasma through capillary walls, from the blood circulatory ... engraftment syndrome, hemophagocytic lymphohistiocytosis, the ovarian hyperstimulation syndrome, viral hemorrhagic fevers, and ...
... Ruri CHIHARA1), Hidetomo NAKAMOTO1), Hiroshi ARIMA1), Kenshi MORIWAKI1), Yoshihiko KANNO1), ... Systemic capillary leak syndrome (SCLS) is characterized by recurrent hypovolemic shock attributable to increased systemic ... capillary leakage. A 46-year-old man was admitted to our hospital because of recurrent episodes of generalized edema with ...
The systemic capillary leak syndrome (SCLS) can be a dramatic, perplexing, and terrifying disease to treat, particularly in its ... The Systemic Capillary Leak Syndrome Bert A. Govig, MD; Sepehr Javaheri, MD ... Govig BA, Javaheri S. The Systemic Capillary Leak Syndrome. Ann Intern Med. 2010;153:764. doi: 10.7326/0003-4819-153-11- ... We thank Druey and Greipp for raising awareness of this rare syndrome and would like to complement their excellent review (1) ...
The Systemic Capillary Leak Syndrome. Ann Intern Med. 2010;153:764. doi: 10.7326/0003-4819-153-11-201012070-00015 ... The very interesting review on the systemic capillary leakage of circulating macromolecules (1) suggests capillary dysfunction ... One wonders whether similar changes also occur in the generalized leakage syndrome. ... Narrative Review: The Systemic Capillary Leak Syndrome The Systemic Capillary Leak Syndrome ...
What is Capillary Leak Syndrome? Meaning of Capillary Leak Syndrome medical term. What does Capillary Leak Syndrome mean? ... Looking for online definition of Capillary Leak Syndrome in the Medical Dictionary? Capillary Leak Syndrome explanation free. ... Anterior tibial compartment syndrome secondary to systemic capillary leak syndrome.. Systemic capillary leak syndrome ... Systemic capillary leak syndrome presenting as recurrent shock.. Systemic capillary leak syndrome associated with pleural ...
Systemic capillary leak syndrome,, Aged, Capillary Leak Syndrome, Female, Humans, Lymphoma, Large B-Cell, Diffuse, 1101 Medical ... suggestive of systemic capillary leak syndrome (SCLS). Further investigations led to a diagnosis of diffuse large B-cell ... Systemic capillary leak syndrome, Non-Hodgkin lymphoma, PATIENT, DISEASE, SERUM, SHOCK, ...
Here we present a patient who suffered from SCLS with hypovolemic shock and compartment syndrome of both lower legs and thighs ... is a rare disorder characterized by increased capillary hyperpermeability leading to hypovolemic shock due to a markedly ... Compartment syndrome of both lower legs and both thighs secondary to Systemic Capillary Leak Syndrome (SCLS). Decompressive ... Systemic Capillary Leak Syndrome (SCLS) is a rare disorder characterized by increased capillary hyperpermeability leading to ...
Connor Thompson of Danielson suffers from systemic capillary leak syndrome, or Clarksons disease. He is one of only five ... Connor Thompson of Danielson suffers from systemic capillary leak syndrome, or Clarkson s disease. He is one of only five ... Connor Thompson also suffers from systemic capillary leak syndrome, or Clarksons disease. He is one of only five children in ... The leak causes a sharp drop in blood pressure, which can lead to organ failure or death. It is very difficult to diagnose, ...
Capillary leak syndrome is a common early posttransplant complication where endothelial cell dysfunction probably contributes ... Patients with later capillary leak syndrome showed increased pretherapy levels of metabolites associated with endothelial ... the pretransplant profile differs for patients with and without posttransplant capillary leak syndrome. Type. Journal article ... Additional bioinformatical analyses showed that capillary leak syndrome was also associated with altered purine/pyrimidine ...
A highly specialized therapy associated with such significant side effects as low blood pressure and capillary leak syndrome, ...
... capillary leak syndrome (CLS), and hemophagocytic lymphohistiocytosis/macrophage activation syndrome (HLH/MAS). Interrupt or ... WARNING: CYTOKINE RELEASE SYNDROME and NEUROLOGICAL TOXICITIES. *Cytokine Release Syndrome (CRS), which may be life-threatening ... Cytokine Release Syndrome (CRS): Life-threatening or fatal CRS occurred in patients receiving BLINCYTO®. Infusion reactions ... Tumor Lysis Syndrome (TLS): Life-threatening or fatal TLS has been observed. Preventive measures, including pretreatment ...
... capillary leak syndrome (CLS), and hemophagocytic lymphohistiocytosis/macrophage activation syndrome (HLH/MAS). Interrupt or ... WARNING: CYTOKINE RELEASE SYNDROME and NEUROLOGICAL TOXICITIES. *Cytokine Release Syndrome (CRS), which may be life-threatening ... Cytokine Release Syndrome (CRS): Life-threatening or fatal CRS occurred in patients receiving BLINCYTO®. Infusion reactions ... Tumor Lysis Syndrome (TLS): Life-threatening or fatal TLS has been observed. Preventive measures, including pretreatment ...
Within the next hour, there condition worsened by respiratory deterioration due to a massive capillary leak syndrome in ... In near-drowning patients, acute lung injury (ALI) or acute respiratory distress syndrome (ARDS) is one of the most common ...
... "capillary leak syndrome" or "vascular leak syndrome." Capillary leak syndrome is a potentially serious disease in which fluids ... Capillary leak syndrome is characterized by the presence of 2 or more of the following 3 symptoms; low blood pressure, swelling ... within the vascular system (veins and capillaries) leaks into the tissue outside the bloodstream. This results in low blood ... Mild flu-like syndrome (fever, headache, generalized aches and pains, weakness and fatigue). ...
Edema, capillary leak syndrome, pleural and/or pericardial effusion, sequestration of granulocytes in the pulmonary circulation ...
... capillary leak syndrome, hypotension, hypoxia, and hemophagocytic lymphohistiocytosis/macrophage activation syndrome. Ensure ... BOXED WARNING: CYTOKINE RELEASE SYNDROME AND NEUROLOGIC TOXICITIES. *Cytokine Release Syndrome (CRS), including fatal or life- ... CYTOKINE RELEASE SYNDROME (CRS): CRS occurred in 94% of patients, including 13% with ≥ Grade 3. Among patients who died after ...
... (ISCLS) is a rare disorder characterized by episodes of severe hypotension, ... Systemic capillary leak syndrome. Intern Med 2002; 41:953.. *Barnadas MA, Cisteró A, Sitjas D, et al. Systemic capillary leak ... Systemic capillary leak syndrome causes a compartment syndrome of both lower legs and a forearm. A case report with a review of ... Systemic capillary leak syndrome associated with compartment syndrome and rhabdomyolysis. Anaesth Intensive Care 2006; 34:388. ...
Capillary leak syndrome (‎CLS)‎ has been described in dengue fever but its exact features have not been clearly defined. We ... Capillary leak syndrome in dengue fever. Dengue Bulletin. 2011 Dec; 35: 65-70. ... 2011)‎. Capillary leak syndrome in dengue fever.. WHO Regional Office for South-East Asia.. https://apps.who.int/iris/handle/ ...
Definition of systemic capillary leak syndrome. Provided by Stedmans medical dictionary and Drugs.com. Includes medical terms ... systemic capillary leak syndrome. Definition: a rare disorder of unknown cause presenting with episodic hypotension, ...
Capillary Leak Syndrome (CLS) in patients with severe course of disease is more and more common, and the clinical ... Anorexia in a Patient With Atypical Hemolytic Uremic Syndrome and Systemic Capillary Leak Syndrome: A Case Report ... "The Current Opinions of Capillary Leak Syndrome" written by Jun Su, Ying Zhang, Wei Hu, published by Open Journal of Clinical ... Fatal Primary Capillary Leak Syndrome in a Late Preterm Newborn. The Indian Journal of Pediatrics, 2016. DOI:10.1007/s12098-016 ...
The aim of our study was to elucidate whether the fluid retention syndrome induced by docetaxel is caused by capillary protein ... Capillary Leak Syndrome / chemically induced*, complications. Capillary Permeability. Carcinoma, Non-Small-Cell Lung / drug ... PURPOSE: The aim of our study was to elucidate whether the fluid retention syndrome induced by docetaxel is caused by capillary ... These observations support the theory of a capillary protein leakage.. CONCLUSION: Docetaxel appears to induce an initial ...
... Eiji HIRAOKA1), Yumi MATSUSHIMA1), Yoko INOMOTO ... A case of systemic capillary leak syndrome in a 67-year-old woman is reported. The patient suddenly presented with severe edema ... Although most of the cases of systemic capillary leak syndrome reported previously were accompanied by monoclonal gammopathy, ... this appears to be the first case in which capillary leak syndrome developed in a patient with multiple myeloma.. (Internal ...
We report a case of idiopathic systemic capillary leak syndrome presenting as septic s ... Idiopathic capillary leak syndrome (Clarksons Disease) is a rare angiopathy with a heterogenous phenotype that may present as ... Idiopathic systemic capillary leak syndrome presenting as septic shock: A case report ... Background:Idiopathic capillary leak syndrome (Clarksons Disease) is a rare angiopathy with a heterogenous phenotype that may ...
  • The abdomen, the central nervous system, and the organs (including the lungs) are typically spared, but the extravasation in the extremities is sufficiently massive to cause circulatory shock and compartment syndromes, with a dangerous hypotension (low blood pressure), hemoconcentration(thickening of the blood) and hypoalbuminemia (drop in albumin, a major protein) in the absence of other causes for such abnormalities. (wikipedia.org)
  • These conditions and factors are sources of secondary capillary leak syndrome. (wikipedia.org)
  • The symptoms result from a sudden and unexplained increase in the leakiness of small blood vessel (capillary) walls. (mayoclinic.org)
  • One study reports that it is caused by chemicals in the body that damage or temporarily separate the cells lining the capillary walls. (mayoclinic.org)
  • Capillary leak syndrome is characterized by the escape of blood plasma through capillary walls, from the blood circulatory system to surrounding tissues, muscle compartments, organs or body cavities. (wikipedia.org)
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