A condition characterized by recurring episodes of fluid leaking from capillaries into extra-vascular compartments causing hematocrit to rise precipitously. If not treated, generalized vascular leak can lead to generalized EDEMA; SHOCK; cardiovascular collapse; and MULTIPLE ORGAN FAILURE.
The property of blood capillary ENDOTHELIUM that allows for the selective exchange of substances between the blood and surrounding tissues and through membranous barriers such as the BLOOD-AIR BARRIER; BLOOD-AQUEOUS BARRIER; BLOOD-BRAIN BARRIER; BLOOD-NERVE BARRIER; BLOOD-RETINAL BARRIER; and BLOOD-TESTIS BARRIER. Small lipid-soluble molecules such as carbon dioxide and oxygen move freely by diffusion. Water and water-soluble molecules cannot pass through the endothelial walls and are dependent on microscopic pores. These pores show narrow areas (TIGHT JUNCTIONS) which may limit large molecule movement.

Evidence for a structural motif in toxins and interleukin-2 that may be responsible for binding to endothelial cells and initiating vascular leak syndrome. (1/91)

The dose-limiting toxicity of interleukin-2 (IL-2) and immunotoxin (IT) therapy in humans is vascular leak syndrome (VLS). VLS has a complex etiology involving damage to vascular endothelial cells (ECs), extravasation of fluids and proteins, interstitial edema, and organ failure. IL-2 and ITs prepared with the catalytic A chain of the plant toxin, ricin (RTA), and other toxins, damage human ECs in vitro and in vivo. Damage to ECs may initiate VLS; if this damage could be avoided without losing the efficacy of ITs or IL-2, larger doses could be administered. In this paper, we provide evidence that a three amino acid sequence motif, (x)D(y), in toxins and IL-2 damages ECs. Thus, when peptides from RTA or IL-2 containing this sequence motif are coupled to mouse IgG, they bind to and damage ECs both in vitro and, in the case of RTA, in vivo. In contrast, the same peptides with a deleted or mutated sequence do not. Furthermore, the peptide from RTA attached to mouse IgG can block the binding of intact RTA to ECs in vitro and vice versa. In addition, RTA, a fragment of Pseudomonas exotoxin A (PE38-lys), and fibronectin also block the binding of the mouse IgG-RTA peptide to ECs, suggesting that an (x)D(y) motif is exposed on all three molecules. Our results suggest that deletions or mutations in this sequence or the use of nondamaging blocking peptides may increase the therapeutic index of both IL-2, as well as ITs prepared with a variety of plant or bacterial toxins.  (+info)

Intrapulmonary protein leakage in immunocompromised children and adults with pneumonia. (2/91)

BACKGROUND: Pulmonary infections are associated with an increase in capillary permeability but information regarding age related differences in the local inflammatory response is lacking. To quantify the degree of capillary leakage during inflammation, the concentrations of the plasma proteins albumin, alpha1-antitrypsin, alpha2-macroglobulin and the locally produced proteins elastase, myeloperoxidase, lactoferrin and fibronectin were studied in the bronchoalveolar lavage (BAL) fluid of immunosuppressed children and adults with pneumonia. METHODS: Sixteen children aged 2-16 years and 15 adults who developed pneumonia while receiving immunosuppressive therapy for haematological malignancies were included in the study. Bronchoalveolar lavage was performed via a flexible bronchoscope with three aliquots of 1 ml/kg body weight in children and 200 ml in adults. Protein concentrations in BAL fluid were determined using highly sensitive immunoluminometric assays. RESULTS: Despite considerable variability, the median concentrations of all proteins in BAL fluid were significantly higher in both patient populations than in previously collected age adjusted reference values. The concentrations of serum derived proteins were significantly higher in children with pneumonia than in adult patients. In contrast, no differences were observed between the two groups for locally produced proteins. CONCLUSIONS: These data suggest that the degree of protein exudation is more pronounced in immunosuppressed children with pneumonia than in adults in a similar clinical situation. This is in agreement with our studies in healthy individuals and may reflect a greater permeability of the alveolar-capillary membrane in children, regardless of disease status.  (+info)

Evidence for the involvement of CD44 in endothelial cell injury and induction of vascular leak syndrome by IL-2. (3/91)

At sites of chronic inflammation seen during infections, autoimmunity, graft-vs-host response, and cytokine therapy, endothelial cell injury is known to occur, the exact mechanism of which is unknown. In the current study we used IL-2-induced vascular leak syndrome (VLS) as a model to investigate whether cytotoxic lymphocytes use CD44 in mediating endothelial cell injury. Administration of IL-2 to wild-type mice triggered significant VLS in the lungs and liver. In contrast, in CD44 knockout (KO) mice, IL-2-induced VLS was markedly reduced in the lungs and liver. IL-2-treated wild-type and CD44 KO mice had similar levels of perivascular infiltration with lymphocytes in the lungs and liver. This suggested that the decrease in VLS seen in CD44 KO mice was not due to the inability of lymphocytes to migrate to these organs. Ultrastructural studies demonstrated extensive endothelial cell damage in the lungs and liver of IL-2-treated wild-type, but not CD44 KO, mice. Moreover, CD44-KO mice exhibited a marked decrease in IL-2-induced lymphokine-activated killer cell activity. The induction of VLS was dependent on the expression of CD44 on immune cells rather than endothelial cells because adoptive transfer of CD44+, but not CD44- spleen cells along with IL-2 into CD44 KO mice triggered VLS. The IL-2-induced VLS was blocked by administration of F(ab')2 of Abs against CD44. The current study demonstrates that CD44 plays a key role in endothelial cell injury. Blocking CD44 in vivo may offer a novel therapeutic approach to prevent endothelial cell injury by cytotoxic lymphocytes in a variety of clinical disease models.  (+info)

Acute modulation of albumin microvascular leakage by advanced glycation end products in microcirculation of diabetic rats in vivo. (4/91)

Advanced glycation end products (AGEs) are nonenzymatic glycosylated adducts of proteins that accumulate in vascular tissue during diabetes and aging. The aim of this work was to study the role of AGEs and of the oxidative mechanisms in diabetes-induced changes in vascular permeability. Intravital videomicroscopy was used to study albumin microvascular leakage in cremaster muscle. The extravasation of a fluorescent macromolecular tracer (fluorescein isothiocyanate-albumin) was measured for 1 h and, after computer-aided image analysis, was expressed as variations of normalized gray levels (arbitrary units). Extravasation of the macromolecular tracer was much higher in diabetic rats than in control rats (slope of extravasation versus time increased by >100%, P < 10(-4)). This increase was significantly inhibited when we blocked AGEs binding to their endothelial receptor by intravenous bolus of soluble recombinant receptor to AGEs (rR-RAGE) (slope of extravasation versus time decreased by 19, 30, and 40%, for 0.5, 2.5, and 5.15 mg/kg rR-RAGE, respectively) or by a 6 mg/kg intravenous bolus of antibody against RAGE (slope decreased by 53%). Systemic injection of probucol (an antioxidant) also significantly inhibited the increase in the extravasation of the macromolecular tracer occurring in experimental diabetes (slope decreased by 51%, P < 10(-4)). These results strongly suggest that in experimental diabetes the interaction of circulating AGEs and endothelial RAGE mediates albumin micro-vascular leakage, possibly via AGE-RAGE-dependent enhanced oxidant stress.  (+info)

Adjuvant treatment of severe acute pancreatitis with C1 esterase inhibitor concentrate after haematopoietic stem cell transplantation. (5/91)

BACKGROUND: With an incidence of 4%, acute pancreatitis is a common complication of bone marrow or peripheral haematopoietic stem cell transplantation, which contributes significantly to morbidity and mortality in these patients. In most cases, the pathogenesis of acute pancreatitis cannot be attributed to a single pathogenetic factor, as treatment toxicity, acute graft versus host disease, infection, and cholestasis may all contribute. Acute pancreatitis is characterised by inflammation and activation of digestive proenzymes leading to autodigestive destruction of the pancreas and systemic activation of protease cascades including the complement system. AIM: To describe the effects of human C1 esterase inhibitor in two children, who developed severe acute pancreatitis with considerable complement activation after allogeneic haematopoietic stem cell transplantation. METHODS: Both children showed clinical features resembling those observed in capillary leakage syndrome. In both patients, treatment with C1 esterase inhibitor concentrate contributed to a rapid clinical stabilisation. CONCLUSIONS: These observations strongly support the proposed pathophysiological concept that early treatment with C1 esterase inhibitor interferes with the activation of the complement system in acute pancreatitis. Inhibition of complement activation prevents its adverse effects on vascular function and permeability, and thus stabilises intravascular fluid status and prevents multiorgan failure in acute pancreatitis.  (+info)

Effect of endothelin and endothelin receptor blockade on capillary permeability in experimental pancreatitis. (6/91)

BACKGROUND: Capillary leakage with fluid loss into the third space contributes to many of the early systemic complications in severe acute pancreatitis. There has been increasing interest in endothelin as one of the factors affecting capillary permeability. AIM: To elucidate further the role of endothelin in the development of capillary leakage in acute pancreatitis by investigating the effect of exogenous endothelin administration and endothelin receptor blockade in sham operated animals and two models of acute pancreatitis. METHODS: Determination of capillary permeability in the pancreas and colonic mucosa by quantifying extravasation of fluorescein labelled dextran using a novel computer assisted video image analysis system. RESULTS: Pancreatic and colonic capillary permeability increased stepwise from mild to severe acute pancreatitis. Endothelin increased pancreatic and colonic capillary permeability in healthy animals and animals with mild acute pancreatitis but had no additional adverse effect in severe acute pancreatitis. Endothelin receptor blockade decreased pancreatic capillary permeability in sham operated rats but had no effect on the colon. In mild and severe acute pancreatitis, endothelin receptor blockade stabilised increased capillary permeability in both the pancreas and colon. CONCLUSIONS: Endothelin plays an important role in mediating capillary permeability in the pancreas. In severe pancreatitis, it increases capillary permeability even outside the pancreas, thereby contributing to capillary leakage. Endothelin receptor blockade significantly reduces capillary permeability in acute pancreatitis both in and outside the pancreas, suggesting a therapeutic approach to counteract capillary leakage in severe acute pancreatitis.  (+info)

Sensitive blood-retinal barrier breakdown quantitation using Evans blue. (7/91)

PURPOSE: This study investigated whether a nonradioactive dye, Evans blue, can be adapted as a safe alternative to the isotope-dilution method for quantitating blood-retinal barrier breakdown. METHODS: Blood-retinal barrier breakdown was induced in rats with vascular endothelial growth factor (VEGF) or through the induction of diabetes. After allowing Evans blue to circulate in the vasculature, the dye was cleared from the bloodstream with saline, citrate, or citrate-buffered paraformaldehyde, and the efficacies of the perfusion solutions were compared. Extravasated dye was detected at 620 nm and was normalized against the time-averaged Evans blue plasma concentration, the circulation time, and also against wet and dry retina weights. RESULTS: Evans blue leakage from retinas treated with VEGF was 4.0-fold higher than that of contralateral untreated eyes (n = 6 rats, P: < 0.05). Retinal Evans blue leakage of eyes from 1-week diabetic animals (n = 11 retinas) was 1.7-fold higher (P: < 0.05) than that of nondiabetic controls (n = 10 retinas). Intra-animal, inter-retina weights showed significantly less variability (P: < 0.05) with the use of dry weights (11.2%, n = 74 retina pairs) than with wet weights (20.5%, n = 93 retina pairs). CONCLUSIONS: The Evans blue dye technique can be modified to be as sensitive and quantitative as the isotope-dilution method for measuring blood-retinal barrier breakdown. The advantages of the Evans blue technique are its safety, relative simplicity, and economy.  (+info)

The toxicity of deglycosylated ricin A chain-containing immunotoxins in patients with non-Hodgkin's lymphoma is exacerbated by prior radiotherapy: a retrospective analysis of patients in five clinical trials. (8/91)

A retrospective analysis of 102 patients with relapsed, non-Hodgkin's lymphoma treated with two different ricin A chain-containing immunotoxins (ITs) in five Phase I clinical trials indicates that the dose-limiting toxicity, vascular leak syndrome, was more frequent and more severe in patients who had undergone prior radiotherapy (RT). Excluding patients with prior RT from the calculations of the maximum tolerated dose indicates that the maximum tolerated doses of these ITs had not been reached in any trial and are clearly higher than reported previously. Excluding patients with prior RT from future clinical trials may increase the dose of ITs that can be given in the absence of severe vascular leak syndrome.  (+info)

Capillary leak syndrome (CLS) is a rare, but serious condition characterized by the abnormal leakage of plasma from the bloodstream into surrounding tissues. This occurs due to increased permeability of the capillary walls, which are the smallest blood vessels in the body that connect arterioles and venules, allowing for the exchange of nutrients, waste products, and gases between the blood and the tissues.

In CLS, the leakage of plasma leads to a rapid loss of intravascular volume, resulting in hypotension (low blood pressure), hemoconcentration (increased concentration of red blood cells due to reduced plasma volume), and edema (swelling) in various parts of the body. The fluid shift from the bloodstream to the tissues can also cause organ dysfunction and failure if not promptly treated.

The exact causes of capillary leak syndrome are not fully understood, but it can be associated with certain medical conditions, such as infections, autoimmune disorders, medications, or cancer. In some cases, CLS may occur without an identifiable underlying cause, known as idiopathic capillary leak syndrome.

Treatment for capillary leak syndrome typically involves supportive care to maintain blood pressure, replace lost fluids and electrolytes, and manage any organ dysfunction. Medications such as corticosteroids, immunoglobulins, or vasopressors may be used depending on the severity of the condition and the presence of underlying causes. In severe cases, extracorporeal membrane oxygenation (ECMO) or other intensive care interventions might be necessary to support organ function and ensure adequate blood flow.

Capillary permeability refers to the ability of substances to pass through the walls of capillaries, which are the smallest blood vessels in the body. These tiny vessels connect the arterioles and venules, allowing for the exchange of nutrients, waste products, and gases between the blood and the surrounding tissues.

The capillary wall is composed of a single layer of endothelial cells that are held together by tight junctions. The permeability of these walls varies depending on the size and charge of the molecules attempting to pass through. Small, uncharged molecules such as water, oxygen, and carbon dioxide can easily diffuse through the capillary wall, while larger or charged molecules such as proteins and large ions have more difficulty passing through.

Increased capillary permeability can occur in response to inflammation, infection, or injury, allowing larger molecules and immune cells to enter the surrounding tissues. This can lead to swelling (edema) and tissue damage if not controlled. Decreased capillary permeability, on the other hand, can lead to impaired nutrient exchange and tissue hypoxia.

Overall, the permeability of capillaries is a critical factor in maintaining the health and function of tissues throughout the body.

... , or vascular leak syndrome, is characterized by the escape of blood plasma through capillary walls, ... Systemic capillary leak syndrome (SCLS), also called Clarkson's disease, or primary capillary leak syndrome, is a rare, grave ... can also cause capillary leaks. These conditions and factors are sources of secondary capillary leak syndrome. ... engraftment syndrome, hemophagocytic lymphohistiocytosis, the ovarian hyperstimulation syndrome, viral hemorrhagic fevers, and ...
... and adult respiratory distress syndrome; capillary leak syndrome; and posterior reversible encephalopathy syndrome. Pemetrexed ...
The most common adverse effect of high-dose IL-2 therapy is vascular leak syndrome (VLS; also termed capillary leak syndrome). ... a process mechanistically similar to the vascular leakage syndrome, occurs in tumor tissue only. Disruption of the blood flow ... "Low Dose Interleukin-2 in Patients With Stable Ischaemic Heart Disease and Acute Coronary Syndromes (LILACS)" at ClinicalTrials ...
The warning label also states it may cause posterior reversible encephalopathy syndrome, that it may cause capillary leak ... ISBN 978-0-470-09254-5. Siddall E, Khatri M, Radhakrishnan J (July 2017). "Capillary leak syndrome: etiologies, pathophysiology ... syndrome, that it may cause severe lung conditions like pulmonary edema, pneumonia, and adult respiratory distress syndrome, ...
Capillary leak syndrome is a possible side effect of the vaccine. The European Medicines Agency (EMA) listed Guillain-Barré ... The Oxford-AstraZeneca COVID-19 vaccine should not be administered to people who have had capillary leak syndrome. The most ... EMA advises against use in people with history of capillary leak syndrome". European Medicines Agency (Press release). 11 June ... An increased risk of the rare and potentially fatal thrombosis with thrombocytopenia syndrome (TTS) has been associated with ...
He currently suffers from a rare disease called capillary leak syndrome. His TV show Çarkıfelek (Turkey's version of Wheel of ...
These toxicities include neuropathic pain, capillary leak syndrome, and hypersensitivity reaction. Anti-GD2 antibodies have ...
"Vaxzevria: EMA advises against use in people with history of capillary leak syndrome". ema.europa.eu. 11 June 2021. Retrieved ... injection and on 11 June 2021 issued a warning against the administering of this vaccine to people with capillary leak syndrome ... thrombosis with thrombocytopenia syndrome) occurring after the first ...
It is not the same as conditions where the blood vessels leak, such as capillary leak syndrome.[citation needed] Under ... HELLP syndrome, thrombotic thrombocytopenic purpura, hemolytic uremic syndrome, and malignant hypertension may mimic DIC but ... 469-471 ISBN 978-1-4160-2973-1 Rak J, Yu JL, Luyendyk J, Mackman N (2006). "Oncogenes, trousseau syndrome, and cancer-related ... Gando, S (1999). "Disseminated intravascular coagulation and sustained systemic inflammatory response syndrome predict organ ...
Several causes have been speculated, including a capillary leak syndrome from cytokine release from the differentiating myeloid ... "Differentiation (retinoic acid) syndrome". Retrieved 10 March 2011. Tallman MS (February 2002). "Retinoic acid syndrome: a ... and to an increasing use of the term differentiation syndrome to signify this APML treatment complication. The syndrome is ... Retinoic acid syndrome (RAS) is a potentially life-threatening complication observed in people with acute promyelocytic ...
Symptoms of capillary leak syndrome include difficulty breathing, weight gain, hypotension, or swelling of arms, legs and/or ... prescribing information for moxetumomab pasudotox includes a boxed warning about the risk of developing capillary leak syndrome ... The boxed warning also notes the risk of hemolytic uremic syndrome, a condition caused by the abnormal destruction of red blood ... a condition in which fluid and proteins leak out of tiny blood vessels into surrounding tissues. ...
The etiology of retinoic acid syndrome has been attributed to capillary leak syndrome from cytokine release from the ... ATRA therapy is associated with the unique side effect of differentiation syndrome. This is associated with the development of ...
While some reports were positive, others have reported capillary leak syndrome suspected to be the result of overly rapid ... POEMS syndrome (also termed osteosclerotic myeloma, Crow-Fukase syndrome, Takatsuki disease, or PEP syndrome) is a rare ... Some features have been observed in patients with POEMS syndrome but are not yet certain to form part of the syndrome itself. ... affected by POEMS syndrome. The diagnosis of POEMS syndrome is based on meeting its two mandatory criteria, meeting at least ...
Capillary leak syndrome also leads to abnormally high hematocrit counts, because of the episodic leakage of plasma out of the ... In order to maintain pressure, the capillaries branch off to a web of vessels that carry blood into the venules. Through this ... As blood flows through the arterioles, red cells will act a feed hematocrit (Hf), while in the capillaries, a tube hematocrit ( ... The packed cell volume (PCV) can be determined by centrifuging EDTA-treated or heparinized blood in a capillary tube (also ...
... capillary leak syndrome, a build up of fluid around the lungs and around the heart. Irregular heart rhythms have occurred, ... In March 2018 the label was extended to use as a countermeasure for acute radiation syndrome. "US Sargramostim label" (PDF). ... FDA approves Leukine for Acute Radiation Syndrome. Retrieved 29 March 2018. (Articles with short description, Short description ...
The "VHF syndrome" (capillary leak, bleeding diathesis, and circulatory compromise leading to shock) appears in a majority of ... Olson PE, Hames CS, Benenson AS, Genovese EN (1996). "The Thucydides syndrome: Ebola déjà vu? (or Ebola reemergent?)". Emerging ... The former family Bunyaviridae includes the causative agents of Hantavirus hemorrhagic fever with renal syndrome (HV-HFRS) ( ...
Muckle-Wells syndrome Familial Mediterranean fever Systemic capillary leak syndrome Physical urticarias List of cutaneous ... There are several distinct urticarial syndromes including: ...
Since late 2005, Porzecanski has struggled with an exceedingly rare illness, Systemic Capillary Leak Syndrome (SCLS), which ... in list of AU/CLALS Research Fellows Porzecanski in Wilson Center website Porzecanski in Systemic Capillary Leak Syndrome ... He also persuaded the National Institutes of Health to carry out basic biomedical research on this syndrome. In early 2009, ...
... but it is unrelated to capillary leak syndrome (which may cause similar swelling episodes) and eosinophilia-myalgia syndrome ( ... Gleich's syndrome is not a form of the idiopathic hypereosinophilic syndrome in that there is little or no evidence that it ... Gleich syndrome has a good prognosis. Attack severity may improve with steroid treatment. Gleich GJ, Schroeter AL, Marcoux JP, ... Gleich's syndrome is a rare disease in which the body swells up episodically (angioedema), associated with raised antibodies of ...
... syndrome Cantu-Sanchez-Corona-Garcia syndrome Cantu-Sanchez-Corona-Hernandes syndrome Capillary leak syndrome Capillary leak ... CCA syndrome Ccge syndrome CCHS CDG syndrome CDG syndrome type 1A CDG syndrome type 1B CDG syndrome type 1C CDG syndrome type 2 ... syndrome Coffin-Siris syndrome COFS syndrome Cogan-Reese syndrome Cogan syndrome Cohen-Gibson syndrome Cohen-Hayden syndrome ... syndrome type 1 Cockayne syndrome type 2 Cockayne syndrome type 3 Cockayne's syndrome CODAS syndrome Codesette syndrome Coeliac ...
Capillary leak syndrome a rare medical condition where the number and size of the pores in the capillaries are increased which ...
... and capillary leak syndrome. Other common adverse effects include retention or urine for weeks to months after receiving the ...
Severe protein deficiency Nephrotic syndrome Protein-losing enteropathies Capillary leak syndrome In Hb Barts, the high oxygen ...
In addition, the medicine could cause capillary leak syndrome (an unpredictable, potentially life-threatening side effect due ...
... persistent apyrexia and profound capillary leak syndrome (see entry for Clostridium novyi alpha-toxin for details of mechanism ... Severe toxic shock syndrome among previously healthy persons has been described in a small number of C. sordellii cases, most ...
Damage to the endothelial layer of blood vessels caused by these inflammatory mediators can lead to capillary leak syndrome, ... have also been implicated with Guillain-Barré syndrome and a variant of Guillain-Barré called Miller-Fisher syndrome. ... Waterhouse-Friderichsen syndrome, and meningitis. Portions of the LPS from several bacterial strains have been shown to be ... which is likely to develop on the basis of the small bowel bacterial overgrowth syndrome and an increased intestinal ...
Anemia, a decrease in red blood cell count Cytopenia, a decrease in blood cell count Capillary leak syndrome, another cause of ... A specific type of relative polycythemia is Gaisböck syndrome. In this syndrome, primarily occurring in obese men, hypertension ... Couck I, Lewi L (June 2016). "The Placenta in Twin-to-Twin Transfusion Syndrome and Twin Anemia Polycythemia Sequence". Twin ... The recipient twin in a pregnancy undergoing twin-to-twin transfusion syndrome can have polycythemia. The pathophysiology of ...
Cantú syndrome Capgras delusion Capgras syndrome Capillary leak syndrome Caplan's syndrome Carcinoid syndrome Cardiac syndrome ... syndrome Wende-Bauckus syndrome Werner syndrome Wernicke-Korsakoff syndrome West syndrome Westerhof syndrome Wet lung syndrome ... syndrome Lynch syndrome Lyngstadaas syndrome Löffler's syndrome Löfgren syndrome M74 syndrome Macrocephaly-capillary ... syndrome Shone's syndrome Short anagen syndrome Short bowel syndrome short limb syndrome Short man syndrome Short QT syndrome ...
... causing the capillaries in the retina to dilate and leak fluid into the retina. This is less common today with modern lens ... The syndrome is named in honor of S. Rodman Irvine and J. Donald M. Gass. The incidence is more common in older types of ... Irvine-Gass syndrome, pseudophakic cystoid macular edema or postcataract CME is one of the most common causes of visual loss ... Kiernan, Daniel F.; Hariprasad, Seenu M. (1 November 2013). "Controversies in the management of Irvine-Gass syndrome". ...
Acute respiratory distress syndrome (ARDS) is a form of pneumonia in which air sacs become filled with fluid leaking from the ... capillaries lungs. Associated inflammation and edema decrease lung compliance, requiring more aggressive treatment and often ... by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) , Infection Control & Hospital Epidemiology , Cambridge Core". ...
Capillary leak syndrome, or vascular leak syndrome, is characterized by the escape of blood plasma through capillary walls, ... Systemic capillary leak syndrome (SCLS), also called Clarksons disease, or primary capillary leak syndrome, is a rare, grave ... can also cause capillary leaks. These conditions and factors are sources of secondary capillary leak syndrome. ... engraftment syndrome, hemophagocytic lymphohistiocytosis, the ovarian hyperstimulation syndrome, viral hemorrhagic fevers, and ...
Fatal Exacerbations of Systemic Capillary Leak Syndrome Complicating Coronavirus Disease Patricia C. Cheung, A. Robin Eisch, ... Fatal Exacerbations of Systemic Capillary Leak Syndrome Complicating Coronavirus Disease. ... systemic capillary leak syndrome; TNF, tumor necrosis factor. ...
NCPE / capillary leak syndrome. A variety of drugs can cause NCPE. This is a less common pattern of drug-induced involvement ... In severe cases, this syndrome may lead to capillary leakage, renal and hepatic dysfunction, and cardiopulmonary compromise. [ ... This, in turn, leads to a hypoxic effect on the alveolar capillary membrane, resulting in increased capillary permeability. ... Acute chest pain syndrome during bleomycin infusions. Cancer. 1987 May 1. 59 (9):1582-5. [QxMD MEDLINE Link]. ...
capillary leak syndrome. *lymphatic dysfunction (lymphedema). *obesity. *malnutrition. *infections that may trigger ... 2016). Effects of combined use of calcium and vitamin B6 on premenstrual syndrome symptoms: A randomized clinical trial.. https ... found that taking 250 milligrams of magnesium per day improved several symptoms of premenstrual syndrome (PMS), including water ... 2012). Effects of magnesium and vitamin B6 on the severity of premenstrual syndrome symptoms.. https://www.ncbi.nlm.nih.gov/pmc ...
Postmarketing reports: Capillary leak syndrome (CLS)[Ref]. Myelosuppression is the major dose-limiting factor associated with ... Very rare (less than 0.01%): Lyells syndrome (toxic epidermal necrolysis, Stevens Johnson Syndrome ... Postmarketing reports: Posterior reversible encephalopathy syndrome (PRES)[Ref]. Local. Very common (10% or more): Injection ... Uncommon (0.1% to 1%): Renal failure, hemolytic-uremic syndrome[Ref]. Other. The flu-like symptoms usually take place a few ...
We report 2 children with distinct causes of polycythemia, 1 from systemic capillary leak syndrome (SCLS) and the other from ... Polycythemia as an Uncommon Finding in 2 Children, One With Systemic Capillary Leak Syndrome and the Other With Protein-losing ... Polycythemia as an Uncommon Finding in 2 Children, One With Systemic Capillary Leak Syndro ...
Capillary leak syndrome may occur immediately after aldesleukin is given. If you experience any of the following symptoms, tell ... Aldesleukin may cause a severe and life-threatening reaction called capillary leak syndrome (a condition that causes the body ...
Cantalamessa Baldini Ambrosi Syndrome Cantu Sanchez-Corona Fragoso Syndrome Capgras syndrome capillary leak syndrome + ... complex regional pain syndrome + congenital anomalies of kidney and urinary tract syndrome with or without hearing loss, ... Cerebellar Vermis Aplasia with Associated Features suggesting Smith-Lemli-Opitz Syndrome and Meckel Syndrome ... Singleton Merten Syndrome (DOID:9007304). Annotations: Rat: (2) Mouse: (2) Human: (2) Chinchilla: (2) Bonobo: (2) Dog: (2) ...
Risk of capillary leak syndrome. Risk of reduced neutrophil chemotaxis, resulting in sepsis/infection risk, use prophylaxis if ... High-dose aldesleukin therapy has been associated with capillary leak syndrome (CLS), resulting in hypotension and reduced ... Retreatment for those who experienced complications of drug-induced capillary leak syndrome. *Sustained VTach (=5 beats), ... this medication can cause capillary leak syndrome (CLS), a serious condition that can sometimes be fatal. If you develop any of ...
... of participants experienced a potentially serious side effect called capillary leak syndrome, in which fluids and proteins leak ... Capillary leak syndrome is also a side effect of other drugs that contain the same toxin as tagraxofusp, Dr. Lane noted. The ... "With vigilant monitoring and early interventions, capillary leak syndrome was manageable," the study authors wrote. One ... FDA approval of tagraxofusp includes a warning and outlines factors that may increase the risk of capillary leak syndrome, such ...
... the pretransplant profile differs for patients with and without posttransplant capillary leak syndrome  Reikvam, Håkon; ...
The drugs most significant side effect was a potentially dangerous condition known as capillary leak syndrome. During the ... Additionally, the researchers established procedures to detect and treat the syndrome during treatment. ...
... description of Capillary leak syndrome is added.. In section 4.8 (undesirable effects), description of Capillary leak syndrome ...
AstraZeneca COVID-19 Vaccine and COVISHIELD: Risk of Capillary Leak Syndrome AlertHealth professional risk communication , 2021 ...
Idiopathic systemic capillary leak syndrome (SCLS): case report and systematic review of cases reported in the last 16 years. V ... Antisynthetase syndrome: an under-recognized cause of interstitial lung disease. VN Maturu, A Lakshman, A Bal, V Dhir, A Sharma ... Leflunomide-induced DRESS syndrome with renal involvement and vasculitis. B Pinto, V Dhir, S Krishnan, R Nada ...
We hypothesize that polycythemia may be caused by hemoconcentration and used as an early marker of capillary leak syndrome. ... Pertussis-like syndrome often not associated with Bordetella pertussis: 5-year study in a large childrens hospital. Infectious ... BACKGROUND: Multisystem inflammatory syndrome in children (MIS-C) is a novel disease that was identified during the COVID-19 ... A machine-learning algorithm for diagnosis of multisystem inflammatory syndrome in children and Kawasaki disease in the USA: a ...
... and capillary leak syndrome or fluid resuscitation). In those patients with risk factors of at least two different categories ... 35.3%, p = 0.001). None of the cohort patients developed abdominal compartment syndrome. The multivariate analysis showed that ... we conducted daily screening of the four CRF for IAH based on the World Society of Abdominal Compartment Syndrome (WSACS) ... and capillary leak syndrome or fluid resuscitation). In those patients with risk factors of at least two different categories ...
... capillary leak syndrome, hypotension, hypoxia, and hemophagocytic lymphohistiocytosis/macrophage activation syndrome. Ensure ... BOXED WARNING: CYTOKINE RELEASE SYNDROME AND NEUROLOGIC TOXICITIES * Cytokine Release Syndrome (CRS), including fatal or life- ... CYTOKINE RELEASE SYNDROME (CRS) occurred in 94% of patients, with 13% ≥ Grade 3. Among patients who died after receiving ... The Yescarta U.S. Prescribing Information has a BOXED WARNING for the risks of cytokine release syndrome (CRS) and neurologic ...
Increased capillary permeability. Capillary leak syndrome (CLS) has been reported with filgrastim and pegfilgrastim[13]. . ... www.gov.uk/drug-safety-update/filgrastim-and-pegfilgrastim-risk-of-capillary-leak-syndrome (accessed June 2017) ... Filgrastim and pegfilgrastim: risk of capillary leak syndrome. Drug Safety Update 2013. Available at: https:// ... Calcium channel blockers (CCBs) act to increase blood flow into the capillaries as a result of dilation of the small arteries ...
Distributive Shock in the Emergency Department: Sepsis, Anaphylaxis, or Capillary Leak Syndrome? The Journal of Emergency ... Another clue is the pulmonary capillary wedge pressure, or PCWP for short, which is measured by inserting a catheter into a ...
hypoalbuminemia, or capillary leak syndrome). Sometimes multiple factors contribute to hyponatremia.. Sometimes, a low serum ... The syndrome of inappropriate ADH secretion Syndrome of Inappropriate ADH Secretion (SIADH) The syndrome of inappropriate ADH ( ... Rarely, hyponatremia occurs in nephrotic syndrome Overview of Nephrotic Syndrome Nephrotic syndrome is urinary excretion of , 3 ... or nephrotic syndrome Overview of Nephrotic Syndrome Nephrotic syndrome is urinary excretion of , 3 g of protein/day due to a ...
Description: The NPCB would like to alert healthcare professionals that cases of capillary leak syndrome (CLS) have been ... Neupogen® (filgrastim) & Neulastim® (pegfilgrastim): Risk of capillary leak syndrome in patients with cancer (filgastrim & ...
Six Cases of Capillary Leak Syndrome After Moderna COVID Vaccination Being Investigated - Newsweek. * Post author By ... Capillary Leak Syndrome, COVID-19, EudraVigilance, Europe, European Medicines Agency, Moderna, Newsweek, Pharmacovigilance Risk ... is currently investigating six reported cases of capillary leak syndrome in people who were vaccinated with Spikevax, ... www.newsweek.com/six-cases-capillary-leak-syndrome-after-moderna-covid-vaccination-being-investigated-spikevax-1648632 ...
Capillary leak syndrome. 1 (,0.1). Chilblains. 1 (,0.1). Data are presented as n (per 100,000): the reporting rate of adverse ...
Capillary Leak Syndrome 17% 20 Citations (Scopus) * Paediatric non-rhabdomyosarcoma soft tissue sarcomas: the prospective NRSTS ... Assessment of Cancer Predisposition Syndromes in a National Cohort of Children With a Neoplasm. Bakhuizen, J. J., Hopman, S. M ... Imaging features of hepatic sinusoidal obstruction syndrome or veno-occlusive disease in children. Bohte, A. E., Dierselhuis, M ...
Capillary Leak Syndrome 66% 55 Citations (Scopus) * 1993 A Phase I Clinical Trial of Murine Monoclonal Antibody D612 in ...
Capillary Leak Syndrome (CLS). *CLS has been reported after G-CSF administration, including pegfilgrastim products ... Myelodysplastic Syndrome (MDS) and Acute Myeloid Leukemia (AML) in Patients with Breast and Lung Cancer ...
capillary leak syndrome (1) * cataract surgery (1) Filters. * Has Multimedia (2) Specify Date Range. From:. To:. Apply. ...
Capillary Leak Syndromes Clarkson Disease Systemic Capillary Leak Syndrome Clinical Capillary Leak Syndrome - Related but not ... Capillary Leak Syndromes. Clarkson Disease. Clinical Capillary Leak Syndrome. Systemic Capillary Leak Syndrome. ... Capillary Leak Syndrome - Preferred Concept UI. M0029047. Scope note. A condition characterized by recurring episodes of fluid ... A condition characterized by recurring episodes of fluid leaking from capillaries into extra-vascular compartments causing ...
Capillary leak syndrome (CLS) can occur in patients receiving filgrastim products and is characterized by hypotension, ... Acute Radiation Syndrome. Neupogen. Indicated to increase survival in patients acutely exposed to myelosuppressive doses of ... hematopoietic syndrome of acute radiation syndrome). 10 mcg/kg SC as a single daily injection for patients exposed to ... Myelodysplastic syndrome (MDS) and acute myelogenous leukemia (AML) have been reported to occur in the natural history of ...

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