DiseasesPhenomena and ProcessesInformation Science
Capillary Leak SyndromeCapillary PermeabilityHypoproteinemiaDictionaries, MedicalLymphoma, Large B-Cell, Diffuse
Capillary Leak Syndrome: A condition characterized by recurring episodes of fluid leaking from capillaries into extra-vascular compartments causing hematocrit to rise precipitously. If not treated, generalized vascular leak can lead to generalized EDEMA; SHOCK; cardiovascular collapse; and MULTIPLE ORGAN FAILURE.Capillary Permeability: The property of blood capillary ENDOTHELIUM that allows for the selective exchange of substances between the blood and surrounding tissues and through membranous barriers such as the BLOOD-AIR BARRIER; BLOOD-AQUEOUS BARRIER; BLOOD-BRAIN BARRIER; BLOOD-NERVE BARRIER; BLOOD-RETINAL BARRIER; and BLOOD-TESTIS BARRIER. Small lipid-soluble molecules such as carbon dioxide and oxygen move freely by diffusion. Water and water-soluble molecules cannot pass through the endothelial walls and are dependent on microscopic pores. These pores show narrow areas (TIGHT JUNCTIONS) which may limit large molecule movement.Hypoproteinemia: A condition in which total serum protein level is below the normal range. Hypoproteinemia can be caused by protein malabsorption in the gastrointestinal tract, EDEMA, or PROTEINURIA.Dictionaries, MedicalLymphoma, Large B-Cell, Diffuse: Malignant lymphoma composed of large B lymphoid cells whose nuclear size can exceed normal macrophage nuclei, or more than twice the size of a normal lymphocyte. The pattern is predominantly diffuse. Most of these lymphomas represent the malignant counterpart of B-lymphocytes at midstage in the process of differentiation.

Evidence for a structural motif in toxins and interleukin-2 that may be responsible for binding to endothelial cells and initiating vascular leak syndrome. (1/91)

The dose-limiting toxicity of interleukin-2 (IL-2) and immunotoxin (IT) therapy in humans is vascular leak syndrome (VLS). VLS has a complex etiology involving damage to vascular endothelial cells (ECs), extravasation of fluids and proteins, interstitial edema, and organ failure. IL-2 and ITs prepared with the catalytic A chain of the plant toxin, ricin (RTA), and other toxins, damage human ECs in vitro and in vivo. Damage to ECs may initiate VLS; if this damage could be avoided without losing the efficacy of ITs or IL-2, larger doses could be administered. In this paper, we provide evidence that a three amino acid sequence motif, (x)D(y), in toxins and IL-2 damages ECs. Thus, when peptides from RTA or IL-2 containing this sequence motif are coupled to mouse IgG, they bind to and damage ECs both in vitro and, in the case of RTA, in vivo. In contrast, the same peptides with a deleted or mutated sequence do not. Furthermore, the peptide from RTA attached to mouse IgG can block the binding of intact RTA to ECs in vitro and vice versa. In addition, RTA, a fragment of Pseudomonas exotoxin A (PE38-lys), and fibronectin also block the binding of the mouse IgG-RTA peptide to ECs, suggesting that an (x)D(y) motif is exposed on all three molecules. Our results suggest that deletions or mutations in this sequence or the use of nondamaging blocking peptides may increase the therapeutic index of both IL-2, as well as ITs prepared with a variety of plant or bacterial toxins.  (+info)

Intrapulmonary protein leakage in immunocompromised children and adults with pneumonia. (2/91)

BACKGROUND: Pulmonary infections are associated with an increase in capillary permeability but information regarding age related differences in the local inflammatory response is lacking. To quantify the degree of capillary leakage during inflammation, the concentrations of the plasma proteins albumin, alpha1-antitrypsin, alpha2-macroglobulin and the locally produced proteins elastase, myeloperoxidase, lactoferrin and fibronectin were studied in the bronchoalveolar lavage (BAL) fluid of immunosuppressed children and adults with pneumonia. METHODS: Sixteen children aged 2-16 years and 15 adults who developed pneumonia while receiving immunosuppressive therapy for haematological malignancies were included in the study. Bronchoalveolar lavage was performed via a flexible bronchoscope with three aliquots of 1 ml/kg body weight in children and 200 ml in adults. Protein concentrations in BAL fluid were determined using highly sensitive immunoluminometric assays. RESULTS: Despite considerable variability, the median concentrations of all proteins in BAL fluid were significantly higher in both patient populations than in previously collected age adjusted reference values. The concentrations of serum derived proteins were significantly higher in children with pneumonia than in adult patients. In contrast, no differences were observed between the two groups for locally produced proteins. CONCLUSIONS: These data suggest that the degree of protein exudation is more pronounced in immunosuppressed children with pneumonia than in adults in a similar clinical situation. This is in agreement with our studies in healthy individuals and may reflect a greater permeability of the alveolar-capillary membrane in children, regardless of disease status.  (+info)

Evidence for the involvement of CD44 in endothelial cell injury and induction of vascular leak syndrome by IL-2. (3/91)

At sites of chronic inflammation seen during infections, autoimmunity, graft-vs-host response, and cytokine therapy, endothelial cell injury is known to occur, the exact mechanism of which is unknown. In the current study we used IL-2-induced vascular leak syndrome (VLS) as a model to investigate whether cytotoxic lymphocytes use CD44 in mediating endothelial cell injury. Administration of IL-2 to wild-type mice triggered significant VLS in the lungs and liver. In contrast, in CD44 knockout (KO) mice, IL-2-induced VLS was markedly reduced in the lungs and liver. IL-2-treated wild-type and CD44 KO mice had similar levels of perivascular infiltration with lymphocytes in the lungs and liver. This suggested that the decrease in VLS seen in CD44 KO mice was not due to the inability of lymphocytes to migrate to these organs. Ultrastructural studies demonstrated extensive endothelial cell damage in the lungs and liver of IL-2-treated wild-type, but not CD44 KO, mice. Moreover, CD44-KO mice exhibited a marked decrease in IL-2-induced lymphokine-activated killer cell activity. The induction of VLS was dependent on the expression of CD44 on immune cells rather than endothelial cells because adoptive transfer of CD44+, but not CD44- spleen cells along with IL-2 into CD44 KO mice triggered VLS. The IL-2-induced VLS was blocked by administration of F(ab')2 of Abs against CD44. The current study demonstrates that CD44 plays a key role in endothelial cell injury. Blocking CD44 in vivo may offer a novel therapeutic approach to prevent endothelial cell injury by cytotoxic lymphocytes in a variety of clinical disease models.  (+info)

Acute modulation of albumin microvascular leakage by advanced glycation end products in microcirculation of diabetic rats in vivo. (4/91)

Advanced glycation end products (AGEs) are nonenzymatic glycosylated adducts of proteins that accumulate in vascular tissue during diabetes and aging. The aim of this work was to study the role of AGEs and of the oxidative mechanisms in diabetes-induced changes in vascular permeability. Intravital videomicroscopy was used to study albumin microvascular leakage in cremaster muscle. The extravasation of a fluorescent macromolecular tracer (fluorescein isothiocyanate-albumin) was measured for 1 h and, after computer-aided image analysis, was expressed as variations of normalized gray levels (arbitrary units). Extravasation of the macromolecular tracer was much higher in diabetic rats than in control rats (slope of extravasation versus time increased by >100%, P < 10(-4)). This increase was significantly inhibited when we blocked AGEs binding to their endothelial receptor by intravenous bolus of soluble recombinant receptor to AGEs (rR-RAGE) (slope of extravasation versus time decreased by 19, 30, and 40%, for 0.5, 2.5, and 5.15 mg/kg rR-RAGE, respectively) or by a 6 mg/kg intravenous bolus of antibody against RAGE (slope decreased by 53%). Systemic injection of probucol (an antioxidant) also significantly inhibited the increase in the extravasation of the macromolecular tracer occurring in experimental diabetes (slope decreased by 51%, P < 10(-4)). These results strongly suggest that in experimental diabetes the interaction of circulating AGEs and endothelial RAGE mediates albumin micro-vascular leakage, possibly via AGE-RAGE-dependent enhanced oxidant stress.  (+info)

Adjuvant treatment of severe acute pancreatitis with C1 esterase inhibitor concentrate after haematopoietic stem cell transplantation. (5/91)

BACKGROUND: With an incidence of 4%, acute pancreatitis is a common complication of bone marrow or peripheral haematopoietic stem cell transplantation, which contributes significantly to morbidity and mortality in these patients. In most cases, the pathogenesis of acute pancreatitis cannot be attributed to a single pathogenetic factor, as treatment toxicity, acute graft versus host disease, infection, and cholestasis may all contribute. Acute pancreatitis is characterised by inflammation and activation of digestive proenzymes leading to autodigestive destruction of the pancreas and systemic activation of protease cascades including the complement system. AIM: To describe the effects of human C1 esterase inhibitor in two children, who developed severe acute pancreatitis with considerable complement activation after allogeneic haematopoietic stem cell transplantation. METHODS: Both children showed clinical features resembling those observed in capillary leakage syndrome. In both patients, treatment with C1 esterase inhibitor concentrate contributed to a rapid clinical stabilisation. CONCLUSIONS: These observations strongly support the proposed pathophysiological concept that early treatment with C1 esterase inhibitor interferes with the activation of the complement system in acute pancreatitis. Inhibition of complement activation prevents its adverse effects on vascular function and permeability, and thus stabilises intravascular fluid status and prevents multiorgan failure in acute pancreatitis.  (+info)

Effect of endothelin and endothelin receptor blockade on capillary permeability in experimental pancreatitis. (6/91)

BACKGROUND: Capillary leakage with fluid loss into the third space contributes to many of the early systemic complications in severe acute pancreatitis. There has been increasing interest in endothelin as one of the factors affecting capillary permeability. AIM: To elucidate further the role of endothelin in the development of capillary leakage in acute pancreatitis by investigating the effect of exogenous endothelin administration and endothelin receptor blockade in sham operated animals and two models of acute pancreatitis. METHODS: Determination of capillary permeability in the pancreas and colonic mucosa by quantifying extravasation of fluorescein labelled dextran using a novel computer assisted video image analysis system. RESULTS: Pancreatic and colonic capillary permeability increased stepwise from mild to severe acute pancreatitis. Endothelin increased pancreatic and colonic capillary permeability in healthy animals and animals with mild acute pancreatitis but had no additional adverse effect in severe acute pancreatitis. Endothelin receptor blockade decreased pancreatic capillary permeability in sham operated rats but had no effect on the colon. In mild and severe acute pancreatitis, endothelin receptor blockade stabilised increased capillary permeability in both the pancreas and colon. CONCLUSIONS: Endothelin plays an important role in mediating capillary permeability in the pancreas. In severe pancreatitis, it increases capillary permeability even outside the pancreas, thereby contributing to capillary leakage. Endothelin receptor blockade significantly reduces capillary permeability in acute pancreatitis both in and outside the pancreas, suggesting a therapeutic approach to counteract capillary leakage in severe acute pancreatitis.  (+info)

Sensitive blood-retinal barrier breakdown quantitation using Evans blue. (7/91)

PURPOSE: This study investigated whether a nonradioactive dye, Evans blue, can be adapted as a safe alternative to the isotope-dilution method for quantitating blood-retinal barrier breakdown. METHODS: Blood-retinal barrier breakdown was induced in rats with vascular endothelial growth factor (VEGF) or through the induction of diabetes. After allowing Evans blue to circulate in the vasculature, the dye was cleared from the bloodstream with saline, citrate, or citrate-buffered paraformaldehyde, and the efficacies of the perfusion solutions were compared. Extravasated dye was detected at 620 nm and was normalized against the time-averaged Evans blue plasma concentration, the circulation time, and also against wet and dry retina weights. RESULTS: Evans blue leakage from retinas treated with VEGF was 4.0-fold higher than that of contralateral untreated eyes (n = 6 rats, P: < 0.05). Retinal Evans blue leakage of eyes from 1-week diabetic animals (n = 11 retinas) was 1.7-fold higher (P: < 0.05) than that of nondiabetic controls (n = 10 retinas). Intra-animal, inter-retina weights showed significantly less variability (P: < 0.05) with the use of dry weights (11.2%, n = 74 retina pairs) than with wet weights (20.5%, n = 93 retina pairs). CONCLUSIONS: The Evans blue dye technique can be modified to be as sensitive and quantitative as the isotope-dilution method for measuring blood-retinal barrier breakdown. The advantages of the Evans blue technique are its safety, relative simplicity, and economy.  (+info)

The toxicity of deglycosylated ricin A chain-containing immunotoxins in patients with non-Hodgkin's lymphoma is exacerbated by prior radiotherapy: a retrospective analysis of patients in five clinical trials. (8/91)

A retrospective analysis of 102 patients with relapsed, non-Hodgkin's lymphoma treated with two different ricin A chain-containing immunotoxins (ITs) in five Phase I clinical trials indicates that the dose-limiting toxicity, vascular leak syndrome, was more frequent and more severe in patients who had undergone prior radiotherapy (RT). Excluding patients with prior RT from the calculations of the maximum tolerated dose indicates that the maximum tolerated doses of these ITs had not been reached in any trial and are clearly higher than reported previously. Excluding patients with prior RT from future clinical trials may increase the dose of ITs that can be given in the absence of severe vascular leak syndrome.  (+info)

Capillary Leak Syndrome | definition of Capillary Leak Syndrome by Medical dictionaryCapillary Leak Syndrome | definition of Capillary Leak Syndrome by Medical dictionary
Looking for online definition of Capillary Leak Syndrome in the Medical Dictionary? Capillary Leak Syndrome explanation free. What is Capillary Leak Syndrome? Meaning of Capillary Leak Syndrome medical term. What does Capillary Leak Syndrome mean?
Capillary leak syndrome - WikipediaCapillary leak syndrome - Wikipedia
Capillary leak syndrome is characterized by the escape of blood plasma through capillary walls, from the blood circulatory system to surrounding tissues, muscle compartments, organs or body cavities. It is a phenomenon most commonly witnessed in sepsis, and less frequently in autoimmune diseases, differentiation syndrome, engraftment syndrome, hemophagocytic lymphohistiocytosis, the ovarian hyperstimulation syndrome, viral hemorrhagic fevers, and snakebite and ricin poisoning. Pharmaceuticals, including the chemotherapy medication gemcitabine, as well as certain interleukins and monoclonal antibodies, can also cause capillary leaks. These conditions and factors are sources of secondary capillary leak syndrome. Systemic capillary leak syndrome (SCLS, or Clarksons disease), or primary capillary leak syndrome, is a rare, grave and episodic medical condition observed largely in otherwise healthy individuals mostly in middle age. It is characterized by self-reversing episodes during which the ...
Systemic Capillary Leak SyndromeSystemic Capillary Leak Syndrome
... (SCLS) is characterized by recurrent hypovolemic shock attributable to increased systemic capillary leakage. A 46-year-old man was admitted to our hospital because of recurrent episodes of generalized edema with hypovolemic shock. Blood laboratory data revealed severe hypoproteinemia with a small monoclonal IgG-κ protein. These findings suggested strongly the diagnosis of SCLS. A regimen with steroid pulse therapy was tried; however, intravascular overloading accompanied by the recruitment of the initially extravasated fluids resulted in acute pulmonary edema. Intensive care and careful monitoring of fluid volume are required in SCLS ...
A Remarkable Coexistence of Systemic Capillary Leak Syndrome and Diabetes in an 11-Year-Old Boy: A Case Report and Review of...A Remarkable Coexistence of Systemic Capillary Leak Syndrome and Diabetes in an 11-Year-Old Boy: A Case Report and Review of...
Systemic capillary leak syndrome (ISCLS) is a rare disease characterized by unexplained reversible capillary hyperpermeability followed by hypoperfusion, hemoconcentration, and either hypoalbuminemia or total hypoproteinemia. An 11-year-old boy was admitted with vomiting, generalized edema, and hyperglycemia, which was preceded by 5 days of coryzal symptoms, lethargy, and oral aft, without fever. On physical examination, he had tachycardia and hypotension, with severe generalized systemic nonitchy edema, and the laboratory tests supported the conclusion that he had severe hemoconcentration with hemoglobin: 184 g/L, hematocrit: 51.3 %, urea: 20 mmol/L, blood glucose: 11.1 mmol/L, and albumin: 19 gr/L, with normal urine analysis. On the fourth day, the patient was diagnosed with ISCLS, by ruling out other causes of shock and hypoalbuminemia. Intravenous immunoglobulin (IVIG) treatment regimen was administered on two consecutive days (day five and day six). His
Systemic capillary leak syndrome revealing a diffuse large B-cell lymphomaSystemic capillary leak syndrome revealing a diffuse large B-cell lymphoma
We report on a 75-year-old woman who presented with recurrent episodes of hypotension, anasarca, renal failure, hypoalbuminaemia without proteinuria, suggestive of systemic capillary leak syndrome (SCLS). Further investigations led to a diagnosis of diffuse large B-cell lymphoma. Secondary SCLS associated with non-Hodgkin lymphoma is reviewed. ...
The Systemic Capillary Leak Syndrome | Annals of Internal Medicine | American College of PhysiciansThe Systemic Capillary Leak Syndrome | Annals of Internal Medicine | American College of Physicians
The systemic capillary leak syndrome (SCLS) can be a dramatic, perplexing, and terrifying disease to treat, particularly in its initial presentation. We have treated a patient with recurrent SCLS and have consulted by telephone on another patient. We thank Druey and Greipp for raising awareness of this rare syndrome and would like to complement their excellent review (1) with our anecdotal experience and 3 comments ...
The Systemic Capillary Leak Syndrome: Appearance of Interleukin-2-Receptor-Positive Cells during Attacks | Annals of Internal...The Systemic Capillary Leak Syndrome: Appearance of Interleukin-2-Receptor-Positive Cells during Attacks | Annals of Internal...
Recurrent hypovolemic shock due to leakage of plasma from the vascular space without an apparent cause was first described by Clarkson and colleagues (1) in 1960 and was subsequently characterized as systemic capillary leak syndrome (2). Since then, 18 patients have been described, most of whom had an M component in their plasma (3). However, the pathogenesis of this syndrome remains unknown. A clue may come from the fact that the syndrome is also a major complication of treatment of metastatic cancer with interleukin-2 alone or in combination with lymphokine-activated killer cells (4). Studies in animals and in humans showed ...
Systemic capillary leak syndrome - Mayo ClinicSystemic capillary leak syndrome - Mayo Clinic
No one knows exactly what causes this disorder. It doesnt appear to be inherited. One study reports that it is caused by chemicals in the body that damage or temporarily separate the cells lining the capillary walls. This separation allows the walls to become leaky.. With treatment, you may be able to control the disorder and avert attacks for long periods of time. If you have a long-term (chronic) form of the condition, you may experience persistent edema and fluid collection in body cavities without the sudden flares typical of other types of systemic capillary leak syndrome.. ...
Joseph Pede Poetry: GM-CSFJoseph Pede Poetry: GM-CSF
Another serious, but very uncommon side effect of sargramostim is "capillary leak syndrome" or "vascular leak syndrome." Capillary leak syndrome is a potentially serious disease in which fluids within the vascular system (veins and capillaries) leaks into the tissue outside the bloodstream. This results in low blood pressure and poor blood flow to the internal organs. Capillary leak syndrome is characterized by the presence of 2 or more of the following 3 symptoms; low blood pressure, swelling, and low levels of protein in the blood. Your doctor will monitor these things carefully while you are taking sargramostim. You should notify your doctor immediately if you notice dizziness (especially when changing position), sudden swelling or rapid weight gain, little or no urine output (for 8-12 hours), shortness of breath, difficulty breathing, irregular heart beats, or chest pain ...
Systemic Capillary Leak Syndrome associated with hypovolemic shock and compartment syndrome. Use of transpulmonary...Systemic Capillary Leak Syndrome associated with hypovolemic shock and compartment syndrome. Use of transpulmonary...
Systemic Capillary Leak Syndrome (SCLS) is a rare disorder characterized by increased capillary hyperpermeability leading to hypovolemic shock due to a markedly increased shift of fluid and protein from the intravascular to the interstitial space. Hemoconcentration, hypoalbuminemia and a monoclonal gammopathy are characteristic laboratory findings. Here we present a patient who suffered from SCLS with hypovolemic shock and compartment syndrome of both lower legs and thighs. Volume and catecholamine management was guided using transpulmonary thermodilution. Extended hemodynamic monitoring for volume and catecholamine management as well as monitoring of muscle compartment pressure is of crucial importance in SCLS patients.
CiNii 論文 - Systemic Capillary Leak SyndromeCiNii 論文 - Systemic Capillary Leak Syndrome
A 40-year-old woman was referred to our hospital with severe hypovolemic shock and anasarca. The laboratory findings showed marked hemoconcentration and a decrease in total serum protein with the presence of monoclonal IgG-λ. She had had a similar episode of generalized edema 2 years previously. We diagnosed the patient as having typical systemic capillary leak syndrome (SCLS) and she improved gradually after infusion of albumin-containing fluid. SCLS is a very rare condition caused by unexplained episodic capillary hyperpermeability. Its treatment has remained largely supportive and the prognosis is generally poor. Awareness of SCLS is necessary for improvement of the outcome.,br,(Internal Medicine 41: 211-215, 2002). ...
Metabolic serum profiles for patients receiving allogeneic stem cell transplantation: the pretransplant profile differs for...Metabolic serum profiles for patients receiving allogeneic stem cell transplantation: the pretransplant profile differs for...
Allogeneic stem cell transplantation is commonly used in the treatment of younger patients with severe hematological diseases, and endothelial cells seem to be important for the development of several posttransplant complications. Capillary leak syndrome is a common early posttransplant complication where endothelial cell dysfunction probably contributes to the pathogenesis. In the present study we investigated whether the pretreatment serum metabolic profile reflects a risk of posttransplant capillary leak syndrome. We investigated the pretransplant serum levels of 766 metabolites for 80 consecutive allotransplant recipients. Patients with later capillary leak syndrome showed increased pretherapy levels of metabolites associated with endothelial dysfunction (homocitrulline, adenosine) altered renal regulation of fluid and/or electrolyte balance (betaine, methoxytyramine, and taurine) and altered vascular function (cytidine, adenosine, and methoxytyramine). Additional bioinformatical analyses ...
Only 5 children in U.S. share rare disease of Danielson boy - News - The Bulletin - Norwich, CTOnly 5 children in U.S. share rare disease of Danielson boy - News - The Bulletin - Norwich, CT
Connor Thompson of Danielson suffers from systemic capillary leak syndrome, or Clarksons disease. He is one of only five children in the country with this disease. Today is Rare Disease Day, an awareness event marked all over the world.
Microsystem with integrated capillary leak to mass spectrometer for high sensitivity temperature programmed desorption - Danish...Microsystem with integrated capillary leak to mass spectrometer for high sensitivity temperature programmed desorption - Danish...
Temperature programmed desorption (TPD) is a method for obtaining information about quantities and binding properties of adsorbed species on a surface. A microfabricated flow system for TPD with an integrated capillary leak to a mass spectrometer is presented. The use of an integrated capillary leak minimizes dead volumes in the system, resulting in increased sensitivity and reduced response time. These properties make the system ideal for TPD experiments in a carrier gas. With CO desorbing from platinum as model system, it is shown that CO desorbing in 105 Pa of argon from as little as 0.5 cm2 of platinum foil gives a clear desorption peak. By using the microfabricated flow system, TPD experiments can be performed in a carrier gas with a sensitivity approaching that of TPD experiments in vacuum. ©2004 American Institute of Physics ...
Amgen Presents Data From Three Trials Evaluating BLINCYTO blinatumomab In Acute Lymphoblastic Leukemia At ASH 2015Amgen Presents Data From Three Trials Evaluating BLINCYTO blinatumomab In Acute Lymphoblastic Leukemia At ASH 2015
Contraindications. BLINCYTO® is contraindicated in patients with a known hypersensitivity to blinatumomab or to any component of the product formulation.. Warnings and Precautions. Cytokine Release Syndrome (CRS): Life-threatening or fatal CRS occurred in patients receiving BLINCYTO®. Infusion reactions have occurred and may be clinically indistinguishable from manifestations of CRS. Closely monitor patients for signs and symptoms of serious events such as pyrexia, headache, nausea, asthenia, hypotension, increased alanine aminotransferase (ALT), increased aspartate aminotransferase (AST), increased total bilirubin (TBILI), disseminated intravascular coagulation (DIC), capillary leak syndrome (CLS), and hemophagocytic lymphohistiocytosis/macrophage activation syndrome (HLH/MAS). Interrupt or discontinue BLINCYTO® as outlined in the Prescribing Information (PI). Neurological Toxicities: Approximately 50% of patients receiving BLINCYTO® in clinical trials experienced neurological toxicities. ...
Amgen Submits Supplemental Biologics License Application For BLINCYTO BlinatumomabAmgen Submits Supplemental Biologics License Application For BLINCYTO Blinatumomab
BLINCYTO® is contraindicated in patients with a known hypersensitivity to blinatumomab or to any component of the product formulation.. Warnings and Precautions. Cytokine Release Syndrome (CRS): Life-threatening or fatal CRS occurred in patients receiving BLINCYTO®. Infusion reactions have occurred and may be clinically indistinguishable from manifestations of CRS. Closely monitor patients for signs and symptoms of serious events such as pyrexia, headache, nausea, asthenia, hypotension, increased alanine aminotransferase (ALT), increased aspartate aminotransferase (AST), increased total bilirubin (TBILI), disseminated intravascular coagulation (DIC), capillary leak syndrome (CLS), and hemophagocytic lymphohistiocytosis/macrophage activation syndrome (HLH/MAS). Interrupt or discontinue BLINCYTO® as outlined in the Prescribing Information (PI). Neurological Toxicities: Approximately 50% of patients receiving BLINCYTO® in clinical trials experienced neurological toxicities. Severe, ...
Finanzen - manager magazinFinanzen - manager magazin
CYTOKINE RELEASE SYNDROME (CRS): CRS occurred in 94% of patients, including 13% with ≥ Grade 3. Among patients who died after receiving Yescarta, 4 had ongoing CRS at death. The median time to onset was 2 days (range: 1-12 days) and median duration was 7 days (range: 2-58 days). Key manifestations include fever (78%), hypotension (41%), tachycardia (28%), hypoxia (22%), and chills (20%). Serious events that may be associated with CRS include cardiac arrhythmias (including atrial fibrillation and ventricular tachycardia), cardiac arrest, cardiac failure, renal insufficiency, capillary leak syndrome, hypotension, hypoxia, and hemophagocytic lymphohistiocytosis/macrophage activation syndrome. Ensure that 2 doses of tocilizumab are available prior to infusion of Yescarta. Monitor patients at least daily for 7 days at the certified healthcare facility following infusion for signs and symptoms of CRS. Monitor patients for signs or symptoms of CRS for 4 weeks after infusion. Counsel patients to seek ...
INFUGEM - Infectious Disease AdvisorINFUGEM - Infectious Disease Advisor
Increased risk of hypotension, severe flu-like symptoms, myelosuppression, and asthenia with prolonged infusion beyond 60mins or more frequent than weekly dosing. Permanently discontinue if unexplained dyspnea, severe pulmonary toxicity, hemolytic uremic syndrome (HUS), severe renal impairment, severe hepatotoxicity, capillary leak syndrome (CLS), or posterior reversible encephalopathy syndrome (PRES; confirm with MRI) occurs. Concurrent liver metastases. History of hepatitis, alcoholism, liver cirrhosis. Monitor for myelosuppression; obtain CBCs (w. differential), platelets prior to each dose. Assess renal and hepatic function prior to initiation, then periodically thereafter. Embryo-fetal toxicity. Pregnancy: exclude status prior to initiation. Advise use of effective contraception during and for 6 months (females) or 3 months (males w. female partners) after the last dose. Nursing mothers: not recommended (during and for ≥1 week after the last dose). ...
Most recent papers with the keyword Near drowning | Read by QxMDMost recent papers with the keyword Near drowning | Read by QxMD
Introduction Drowning with submersion over 10 minutes is associated with a high mortality. Here, we present a case, in which a good neurological outcome was achieved after interdisciplinary, intensive care therapy despite submersion of 20 minutes followed by 16 hours of hypoxia. History A 19 year old man drowned in fresh-water. After 20 minutes submersion he was localized and salvaged from 8 meters depth and primarily resuscitated successfully after 10 minutes. Within the next hour, there condition worsened by respiratory deterioration due to a massive capillary leak syndrome in addition to a disseminated intravascular coagulation ...
Vaccine shows therapeutic promise against advanced melanomaVaccine shows therapeutic promise against advanced melanoma
After an NCI-led Phase II study combining the vaccine with Interleukin-2 (IL-2) showed response rates of 42 percent in metastatic melanoma patients, a Phase III randomized trial with the two agents opened more than a decade ago. Conducting a large, multi-institutional trial with IL-2, however, had its own set of unique challenges, explained Hwu, as not all cancer centers and community hospitals are capable of administering the immunotherapy. A highly specialized therapy associated with such significant side effects as low blood pressure and capillary leak syndrome, which poses risks to the heart and lung, IL-2 is often delivered in intensive care units. Just last month, M. D. Anderson opened a special in-patient unit exclusively designed for the drugs delivery; before, the institution was offering the therapy in its ICU.. In the Phase III trial, 185 patients at 21 centers across the country were enrolled in the study. All had advanced metastatic melanoma and were stratified for cutaneous ...
Pissin On The Roses: POTRBLOG Reverse Engineers U.S. Radiological Disaster CONOPS & Identifies Nuclear ThreatsPissin' On The Roses: POTRBLOG Reverse Engineers U.S. Radiological Disaster CONOPS & Identifies Nuclear Threats
Leukine as awarded, and manufactured by Sanofi in Bridgewater NJ will not work as a thrombosome. Edema, capillary leak syndrome, pleural and/or pericardial effusion, sequestration of granulocytes in the pulmonary circulation, and dyspnea have been reported in patients after Leukine administration. Occasional transient supraventricular arrhythmia has been reported during Leukine administration. Leukine has induced the elevation of serum creatinine or bilirubin and hepatic enzymes in some patients. Monitoring of renal and hepatic function in patients with preexisting renal or hepatic dysfunction is recommended at least every other week during Leukine administration.. ReplyDelete ...
RareshareRareshare
Treatment of a fully developed SCLS episode requires recognition that there are two phases. The first phase, which often lasts a couple of days, is called the resuscitation phase because the dual aim of the emergency room (ER) and intensive care unit (ICU) treatment is to stop or control the capillary leak and to raise the patients blood pressure from near zero. In this initial phase, an albumin and fluid leak from the capillaries into the tissue spaces causes swelling, especially into the extremities rather than the abdomen or organs (such as the lungs). The blood pressure falls and the red cells concentrate. This loss of fluid has similar effects on the circulation as dehydration, slowing both the flow of oxygen carrying blood to tissues and the output of urine.. Glucocorticoids (steroids like methylprednisolone) are recommended to reduce or stop the capillary leak, and albumin and colloids usually help to increase the remaining blood flow to vital organs like the kidneys. Keeping up with the ...
Transfusion-related acute lung injury - Cancer Therapy AdvisorTransfusion-related acute lung injury - Cancer Therapy Advisor
Although the etiology of TRALI has not been fully delineated, two hypotheses have been postulated. The antibody-mediated hypothesis proposes that antibodies react with a corresponding antigen triggering capillary leak. Identified antibodies include antibodies to human leukocyte antigen (HLA) class I and II antigens and human neutrophil antigen (HNA). In this hypothesis, antibodies bind to recipient neutrophils. The antibody bound neutrophils are then sequestered in the lungs where activation of complement results in endothelial damage, capillary leak, and ALI. In most of these cases, the antibody is found in the donor with the corresponding antigen identified on the recipients neutrophils. Most donors associated with cases of TRALI are multiparous women who become alloimmunized during pregnancy. One notable case supporting the antibody mediated hypothesis describes a patient who underwent lung transplantation and developed dyspnea and hypoxia after receiving a transfusion of two units of packed ...
Decreases in levels of serum fibronectin predict the severity of vascular leak syndrome in patients treated with ricin A chain...Decreases in levels of serum fibronectin predict the severity of vascular leak syndrome in patients treated with ricin A chain...
TY - JOUR. T1 - Decreases in levels of serum fibronectin predict the severity of vascular leak syndrome in patients treated with ricin A chain-containing immunotoxins. AU - Baluna, Roxana. AU - Sausville, Edward A.. AU - Stone, Marvin J.. AU - Stetler-Stevenson, Mary Alice. AU - Uhr, Jonathan W.. AU - Vitetta, Ellen S.. PY - 1996/10. Y1 - 1996/10. N2 - The major dose-limiting adverse effect of ricin A chain-containing immunotoxin (IT) therapy is vascular leak syndrome (VLS). Since plasma fibronectin (Fn) plays a role in maintaining microcirculatory integrity and since the gradient between plasma and tissue Fn can be altered in various pathological situations, we determined whether the administration of IT-ricin A chain to patients resulted in changes in the levels of serum Fn and, if so, whether these changes correlated with the severity of VLS. We also measured the serum levels of tumor necrosis factor α (TNFα), a proinflammatory cytokine which has been implicated in tissue damage and in ...
Toxic shock syndrome: under-recognised and under-treated? | Archives of Disease in ChildhoodToxic shock syndrome: under-recognised and under-treated? | Archives of Disease in Childhood
Toxic shock syndrome (TSS) is a relatively rare but severe disease that is more common in children than adults and characterised by fever, erythematous rash and multiorgan failure. In this months edition, Adalat and colleagues1 report the results from a British Paediatric Surveillance Unit study of TSS in the UK and RI.. TSS is caused by exotoxins, produced by Staphylococcus aureus and Streptococcus pyogenes (group A streptococci), that are superantigens capable of initiating an uncontrolled inflammatory cascade. Pro-inflammatory cytokines acting on the vascular endothelium cause capillary leak that can ultimately result in hypotension with consequent multiorgan failure. This process, induced by superantigen toxins from Gram-positive bacteria, is similar to, but distinct from, the inflammatory cascade initiated by endotoxin in Gram-negative shock. The term TSS was coined by Dr Jim Todd when he first described the condition in children in 1978. Children are generally more susceptible to TSS as ...
Mesenchymal stromal (stem) cells suppress pro-inflammatory cytokine production but fail to improve survival in experimental...Mesenchymal stromal (stem) cells suppress pro-inflammatory cytokine production but fail to improve survival in experimental...
Toxic shock syndrome (TSS) is caused by an overwhelming host-mediated response to bacterial superantigens produced mainly by Staphylococcus aureus and Streptococcus pyogenes. TSS is characterized by aberrant activation of T cells and excessive release of pro-inflammatory cytokines ultimately resulting in capillary leak, septic shock, multiple organ dysfunction and high mortality rates. No therapeutic or vaccine has been approved by the U.S. Food and Drug Administration for TSS, and novel therapeutic strategies to improve clinical outcome are needed. Mesenchymal stromal (stem) cells (MSCs) are stromal cells capable of self-renewal and differentiation. Moreover, MSCs have immunomodulatory properties, including profound effects on activities of T cells and macrophages in specific contexts. Based on the critical role of host-derived immune mediators in TSS, we hypothesized that MSCs could modulate the host-derived proinflammatory response triggered by Staphylococcal enterotoxin B (SEB) and improve survival
Early perioperative death associated with reexpansion pulmonary edema during liver transplantationEarly perioperative death associated with reexpansion pulmonary edema during liver transplantation
imately half of the cases and its occurrence in the LT setting has been considered an ominous sign. A diffuse alveolar reexpansion, triggering endothelial activation damage involves both the endothelial and epithelial and neutrophil sequestration (priming event). This surfaces and disrupts the lung barrier. Cardinal clinical event would be followed by local enhancement of the features of ARDS are the insidious onset of refractory inflammatory cascade by attracting and activating cir- hypoxemia and bilateral pulmonary infiltrates, but no culating proinflammatory cytokines, antibodies and primed cells generated upon reperfusion, hepatic fail- REPE is a form of non-diffuse, permeability-type PE ure, or TRALI, resulting in endothelial damage and that occasionally occurs following acute evacuation of capillary leak (second-hit).2 In addition, the release of air or fluid from the pleural space, allowing rapid expan- inflammatory mediators into the systemic circulation sion of a long period ...
Septic shock - Cardiology & Pulmonology - Rare Diseases And Symptoms - AOP OrphanSeptic shock - Cardiology & Pulmonology - Rare Diseases And Symptoms - AOP Orphan
Septic shock is a life-threatening condition requiring intense patient monitoring and supportive therapy for organ dysfunction. Release of inflammatory mediators leads to widespread vasodilatation, capillary leak and reduced systemic vascular resistance. After initial fluid resuscitation, vasopressor therapy is required. These agents have their effect by increasing vascular resistance, raising mean arterial pressure and maintaining perfusion of critical body tissues and organ systems. ...
Respiratory Therapy Cave: How does NIV help with CHF?Respiratory Therapy Cave: How does NIV help with CHF?
Contrary to popular belief, NIMV does NOT push edema fluid out of the lungs. Patients with acute CHF have an imbalance in the CO (cardiac output) of the right and left sides of the heart. With the inciting event (detailed above) the left ventricle becomes compromised but the right ventricle usually does not. So the right ventricle continues to pump forward a normal volume of blood but the left ventricle becomes unable to keep pace. Fluid backs up into the lungs resulting in capillary leak and pulmonary edema. With NIMV, the resultant positive intra-thoracic pressure decreases venous return (blood flowing back to the heart). This reduces right-sided CO to a level that the left heart can equal or even exceed. Fluid ceases to back up and will even begin to be reabsorbed as left ventricular CO improves. Pulmonary edema ceases to worsen and may even diminish, often rapidly ...
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Preclinical laboratory experiments with Interleukin 15 (IL-15) have demonstrated significant immunotherapeutic potential for recombinant human IL-15 (rhIL-15) in cancer patients. We have completed a first-in-human (FIH), phase I dose escalation trial of E. coli produced rhIL-15 administered as a 30 minute intravenous bolus (IVB) infusion given daily for 12 consecutive days to patients with metastatic melanoma (MM) or renal cell carcinoma (mRCC). rhIL-15 treatment produced up to an 8-fold expansion of circulating NK cells, approximately 2 fold expansion of CD8+ CD45RO+ memory T-cells and up to 50 fold increases in serum level for multiple cytokines. Characteristic toxicities associated with cytokine treatment such as fever, rigors or chills, capillary leak, myalgias and blood pressure changes occurred at frequency and severity proportional to the dose of rhIL-15. Laboratory results showed early course transient leukopenia, lymphopenia, modest neutropenia, occasional thrombocytopenia and ...
Why does the brain enlarge in cerebral oedema? | Physics Forums - The Fusion of Science and CommunityWhy does the brain enlarge in cerebral oedema? | Physics Forums - The Fusion of Science and Community
I know it sounds obvious. But in cerbral oedema lets say due to vasgenic cause,the problem is cerebral vessels becoming more permeable and leaking out blood to extravascular compartment. Now how does the brain get bigger due to this. I mean for brain to get bigger, the intracellular fluid volume of brain cells must increase. So when these capillaries leak blood out, do near by brain cells absorb these water, increasing their intracellular volume and as a result we get enlarged brain? or does this leaked out fluid get stuck in brain interstitium making it bigger. I hope u understand my confusion, because leaking out fluid must make brain smaller otherwise. Thanks ...
Download Organ Transplantation, 2nd Edition - Vademecum by Frank P. Stuart PDF - BLACKWATERPADDLEANDPEDAL.COM E-booksDownload Organ Transplantation, 2nd Edition - Vademecum by Frank P. Stuart PDF - BLACKWATERPADDLEANDPEDAL.COM E-books
This leads to B cell triggering and internalization of the antigen. 156 Immunologic Concepts 21 The result is that a signal for B cell triggering is delivered, activating intracellular pathways which include the calcium-dependent pathway. To recruit antigen-specific T cell help, B cells must present peptides of allogeneic MHC antigen in the groove of its class II antigens. To accomplish this, the allogeneic MHC antigen bound by sIg is endocytosed, through proteins around the receptor termed α and β,156 and presented as peptides in the class II groove of the B cell. Platelet activating factor (PAF) has been demonstrated in the EC plasma membranes and may act locally on adhering leukocytes. 175,176 Other influences include eicosanoids such as the vasodilator prostacyclin (PGI2) or the vasoconstrictor thromboxane. 177 It is likely that the balance between these two forces contributes to the complex vasomotor changes such as arterial vasoconstriction and capillary leak in acute rejection. 172 ...
Intensive Care Medicine: AbstractIntensive Care Medicine: Abstract
Successful antibiotic therapy in the critically ill requires sufficient drug concentrations at the site of infection that kill or suppress bacterial growth. The relationship between antibiotic exposure and achieving the above effects is referred to as pharmacokinetics/pharmacodynamics (PK/PD). The associated indices therefore provide logical targets for optimal antibiotic therapy. While dosing regimens to achieve such targets have largely been established from studies in animals and non-critically ill patients, they are often poorly validated in the ICU. Endothelial dysfunction, capillary leak, altered major organ blood flow, deranged plasma protein concentrations, extremes of body habitus, the application of extracorporeal support modalities, and a higher prevalence of intermediate susceptibility, independently, and in combination, significantly confound successful antibiotic treatment in this setting. As such, the prescription of standard doses are likely to result in sub-therapeutic ...
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Biousse v, ameri a, bousser mg. But may be followed by mg twice daily none mg ml in the spring when plants are blooming, a ungal smear and an emergent basis. The use of cranial nerve examination is positive or if parenteral nutrition should be arranged when the cellular level that contribute to a persons lifetime. Although the transcellular space is one o the united states or capillary leak or decreased urine output, peripheral perfusion, whereas elevated oxygen saturation at. Epilepsia. Headache classi ication and molecular eatures with acuteonset symmetric limb and shoulder movements developed. Depending on these drugs is perhaps the strongesthevidence for the use of accessory muscles to breathe at birth with cyanosis, the prognosis with combination of ccb + ace i with an initial increase in patients with ptosis. Speci cally to ensure that all manufacturers of nonoxynol products to assess vital signs are seen due to furosemide, the central nervous system involvement. The presence o ...
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The alpha chain of the Il2 receptor, also known as Tac or CD25, is expressed on activated T and B cells, on regulatory T cells (Treg), and to a lesser degree on subpopulations of resting memory T cells (1-5). Tac is also expressed on multiple T- and B-cell malignancies and is therefore a target for cancer therapy (6). LMB-2 is an anti-Tac recombinant immunotoxin (RIT) containing a targeting scFv and a 38-kDa portion of Pseudomonas exotoxin A (PE38) that shows extremely high cytotoxic activity and has been evaluated in several clinical trials (6-9). One such clinical trial involved various hematologic malignancies, including adult T-cell leukemia, B-cell chronic lymphocytic leukemia, anaplastic large-cell lymphomas, B-cell non-Hodgkin lymphoma, Hodgkin disease, and hairy cell leukemia (6). In this trial, a general 3% complete remission and a 20% partial remission rate was observed, with 37% of immunotoxin recipients generating antidrug antibodies (ADA) and with vascular leak syndrome (VLS) ...
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A27 Immunotoxins, a class of biologic therapeutics provide efficacious and specific treatment for cancer as they target surface specific growth factor receptors or antigens over expressed on cancer cells. Immunotoxins have shown promising results in vitro and in vivo. One of the immunotoxin approved for use by FDA is denileukin diftitox; major toxicities with this drug are acute hypersensitivity, vascular leak syndrome and impaired immune function. The latter two toxicities are due to nonspecific binding of immunotoxin to macrophages and activated lymphocytes. We hereby attempted to design an immunotoxin with unaltered efficacy and decreased toxicity. In these immunotoxins, modified diphtheria toxin (DT) acts as cytotoxic moiety and IL-2 as the targeting moiety for cancer cells that over express IL-2 receptor on their surface. IL-2 receptor has three subunits alpha, beta and gamma. Biological effect of IL2 is mediated through IL2 alpha beta gamma receptor and IL2 beta gamma receptor complexes ...
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Background: IL-2 was the first cancer immunotherapy approved, producing durable responses in ∼10% of patients treated for metastatic melanoma and renal cancer. However, IL-2 has poor pharmacokinetics, is both an activator and suppressor of the immune system, and is associated with severe cardiovascular side effects of hypotension and vascular leak syndrome, limiting widespread use. NKTR-214 is a novel immunotherapeutic consisting of IL-2 conjugated at a defined region within the protein to 4-6 polyethylene glycol (PEG) chains. Once administered, PEG chains slowly release to generate active IL-2 conjugates biased towards activation of CD122, the IL-2 receptor beta subunit (IL-2Rβ), highly expressed on memory effector CD8+ T cells (CD8T). In the tumor microenvironment, NKTR-214 preferentially expands CD8T over regulatory T cells (Treg), thus tipping the balance in favor of immune activation with a CD8T/Treg ,400. In syngeneic mouse tumor models, NKTR-214 demonstrated robust single agent ...
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The availability of recombinant cytokines has enabled research into cytokine biology as well as their application in a clinical setting. One aspect which is becoming clear is that the systemic injection of large doses of cytokines is associated with considerable toxicity, usually due to, or accompanied by, vascular leak syndrome. A series of cytokine fusion proteins was produced in an effort not only to reduce cytokine-associated toxicity but also to combine biological effects of cytokines that stimulate the innate immune system with those that promote an adaptive immune response. In this report is described one such fusion molecule that satisfies all of these criteria. A fusion protein combining IL-2 and IL-18 was made to produce a single molecule that would keep intact their biological properties and keep a constant molar ratio of the individual proteins. It was found that the order IL-2/IL-18 was required to maintain secretion and activity. The constructs mproIL-18/IL-2 and mIL-18/IL-2 were ...
SCLS FeedbackSCLS Feedback
This form is provided for member libraries to give feedback about SCLS services and interactions with any of the SCLS staff (ILS, Delivery, Technology, Member Services, etc.). We are very interested in improving our service to members.. Please use the form to let us know about problems and do pass on any positive comments about our service. For specific problems with deliveries (i.e., something came to the wrong library), please call or email Delivery directly.. ...
Clinical - Endothelial Cells - ALPF Medical ResearchClinical - Endothelial Cells - ALPF Medical Research
Unfortunately, to date there are no standardized criteria for the clinical diagnosis of increased microvascular permeability, because the assessment of fluid distribution and fluid balance in septic patients is very difficult. Clearly, early diagnosis of increased microvascular permeability would be valuable, because it would allow early and specified treatment as well as the evaluation of the efficacy of therapeutic efforts. It is important to distinguish between increased microvascular permeability and other hypo-oncotic conditions leading to fluid retention, that is, caused by renal or hepatic failure. Proposed criteria for clinical assessment of the microvascular leak syndrome so far either are nonspecific or have limited bedside applicability: Microvascular leak was defined as noncardiogenic generalized edema and hemodynamic instability or more than 3 percent increase of body weight within 24 hours, combined with generalized edema. In this context, it is worth noting that calculated fluid ...
Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P(1) antagonist in vivoEnhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P(1) antagonist in vivo
Sphingosine 1-phosphate (S1P, 1) regulates vascular barrier and lymphoid development, as well as lymphocyte egress from lymphoid organs, by activating high-affinity S1P1 receptors. We used reversible chemical probes (i) to gain mechanistic insights into S1P systems organization not accessible through genetic manipulations and (ii) to investigate their potential for therapeutic modulation. Vascular (but not airway) administration of the preferred R enantiomer of an in vivo-active chiral S1P1 receptor antagonist induced loss of capillary integrity in mouse skin and lung. In contrast, the antagonist did not affect the number of constitutive blood lymphocytes. Instead, alteration of lymphocyte trafficking and phenotype required supraphysiological elevation of S1P1 tone and was reversed by the antagonist. In vivo two-photon imaging of lymph nodes confirmed requirements for obligate agonism, and the data were consistent with the presence of a stromal barrier mechanism for gating lymphocyte egress. ...
Re: CAPILLARY LEAKAGE SYNDROME( GOODSONS DISEASE) - HealthBoards Message BoardsRe: CAPILLARY LEAKAGE SYNDROME( GOODSON'S DISEASE) - HealthBoards Message Boards
Health related message boards offering discussions of numerous health topics including allergies, cancer, diabetes, heart disease, exercise, attention deficit disorder, diet, and nutrition.
Our Life Giving Table Fall Edition Inspired by Sally Clarksons New Book The Life Giving Table | Bilingual MamiOur Life Giving Table Fall Edition Inspired by Sally Clarkson's New Book The Life Giving Table | Bilingual Mami
As a homeschooling family, much time is spent gathered around our dinner table. It is the place where we eat, yes, but it is so much more than that. Our dinner table is the place where we do school, make crafts - even messy ones, the place where my kids get to help cook different…
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Hello all - I cant seem to upload my Word document here (if someone knows how, please let me know!) so here is the protocol I use. Id rather upload that because its much easier to read:. SCLS Protocol for Jeffrey Zielinski. WARNING:. Jeffrey is a good judge of his symptoms and is educated about his disease.. Normal Values: HCT: 38-46. BP: 110-120/70-80. PULSE: 60-90. Plasma Volume (at 45ml/kg body weight) = 4500ml. DX OF IMPENDING SHOCK OR SHOCK. Elevated BP = impending shock. HCT: usually ,50. BP: 90-110/60-70. PULSE: 110-140, persistently. Also decreased UOP, despite approx 1L of PO fluids at home.. Low or absent BP=shock. HCT,70. SBP,90. PULSE: ,130 and thready. CLINICAL SIGNS: Initially Jeff may be alert, anxious, may have cold, clammy extremities. He will often complain of arm/leg fatigue, lower lumbar pain, increased nasal congestion and facial/neck fullness. May lead to progressive anxiety, leading to confusion, and livido reticularis (mottling) of his skin in severe leaks ...
Blocking of monocyte migration induced by supernatant o | Open-iBlocking of monocyte migration induced by supernatant o | Open-i
Blocking of monocyte migration induced by supernatant of RA SCL stimulated with TNF-α. Monocyte migration induced by supernatants of RA SCLs (RA6/1 and RA8/3)
Smoke inhalation - induced alveolar lung injury is inhibited by hyperbaric oxygenSmoke inhalation - induced alveolar lung injury is inhibited by hyperbaric oxygen
Smoke-induced lung injury in rats was assessed in terms of histopathology, gross mortality, neutrophil accumulation and as capillary leak. Administration of hyperbaric oxygen (HBO2), 2.8 atm abs for 45 min, inhibited adhesion of circulating neutrophils subsequent to smoke inhalation. HBO2 reduced pulmonary neutrophil accumulation whether used in a prophylactic manner, 24 h before smoke inhalation, or as treatment immediately after the smoke insult Emphasis was placed on prophylactic administration of HBO2 to avoid the possibility that beneficial effects may be related to hastened removal of carbon monoxide. Based on all parameters tested, smoke inhalation injury was reduced by prophylactic aadministration of HBO2. The beneficial effect appears related to inhibition of neutroophil adhesion to the vasculature ...
Co-immunotherapy with interleukin-2 and taurolidine for progressive metastatic melanoma.Co-immunotherapy with interleukin-2 and taurolidine for progressive metastatic melanoma.
BACKGROUND: Recombinant interleukin-2(rIL-2) therapy in metastatic melanoma is limited by toxicities, particularly vascular leak syndrome(VLS). Taurolidine potentiates the anti-neoplastic effects of IL-2 while reducing its associated endothelial cell dysfunction in experimental settings. We hypothesized that co-administration of rIL-2 with taurolidine could enhance tolerability without weakening effectiveness. METHODS: Eleven patients with progressive metastatic melanoma received high-dose rIL-2 with co-infusion of taurolidine. Patients were monitored for the development of toxicities and evidence of response. RESULTS: Ten patients tolerated twenty-nine courses of high-dose rIL-2 without dose-reduction. Most toxicities were low-grade. No patient developed VLS. Seven patients died from disease progression. Two had complete clinical and radiological responses to treatment. Two patients remain alive despite evidence of disease progression a mean of 17.5 months after diagnosing metastatic disease. ...
Wettability of SCLs Assessed in a Model Blink-cycle Cell | IOVS | ARVO JournalsWettability of SCLs Assessed in a Model Blink-cycle Cell | IOVS | ARVO Journals
Purpose: : Ideally, soft contact lenses (SCLs) should be highly wettable and immune to oily and proteinaceous tear-film deposits during wear. Therefore, it is important to assess SCL wettability performance when the lens is in contact with human tear film especially the lipid layer. For the first time, we devise and evaluate an in-vitro blink-cycle cell that mimics contact-lens exposure to the human-eye environment during blinking and that permits contact-angle assessment. Methods: : An in-vitro blink-cycle cell was designed to measure contact angles of SCLs during model blink cycles. A syringe pump flows an artificial tear solution into and out of a blink-cycle cell, thereby raising and lowering the liquid level above and below the surface of the lens. The artificial tear solution contains phosphate-buffered saline (PBS), mucin, and tear-film proteins. Importantly, a model tear lipid is spread over the air/water interface to reflect exposure to meibomian lipids. One blink cycle corresponds to ...
Improving patient safety: Usefulness of safety checklists in a neonatal unit | Anales de Pediatría (English Edition)Improving patient safety: Usefulness of safety checklists in a neonatal unit | Anales de Pediatría (English Edition)
The survey on staff satisfaction in relation to the use of SCLs was completed by 48 employees (54% of the staff), 10 doctors and 38 nurses, a difference that was not statistically significant (P=.501). When it came to the usefulness of SCLs, 75% (36/48) considered that SCLs were useful or very useful, 14.58% (7/48) felt indifferent, and 10.42% (5/48) considered them of little use or useless. Of all respondents, 68.75% (33/48) believed that SCLs had succeeded in preventing some AEs. In addition, 87.5% (42/48) of respondents did not feel that SCLs added significantly to their work burden. As for the level of overall satisfaction with SCLs, 54.16% (26/48) reported feeling satisfied or very satisfied, 31.25% (15/48) indifferent and 14.58% (7/48) dissatisfied. One hundred percent of respondents replied Yes to the question "if your child was hospitalised in the neonatology department, would you like safety checklists to be implemented to improve their safety?".. The percentage of respondents that ...
Carbon Dioxide Transport | Anesthesiology Core Review: Part One Basic Exam | AccessAnesthesiology | McGraw-Hill MedicalCarbon Dioxide Transport | Anesthesiology Core Review: Part One Basic Exam | AccessAnesthesiology | McGraw-Hill Medical
In the human body, carbon dioxide (CO2) is a metabolic waste product of aerobic metabolism. Specifically, two catabolic processes, pyruvate decarboxylation and the Krebs cycle, both of which occur in the mitochondria of cells, produce CO2. As a result of these processes, the concentration of CO2 increases proportionally to metabolic activity within tissues, leading to an increased partial pressure of carbon dioxide (Pco2). This pressure gradient drives CO2, a highly lipid-soluble molecule, out of tissues, across cell membranes, and into the blood of systemic capillaries. Once it has diffused into the capillaries, CO2 is transported to the lungs by three mechanisms. ...
Sulfatides-containing liposomes as novel nano carriers targeting gliomas | ScholarBank@NUSSulfatides-containing liposomes as novel nano carriers targeting gliomas | [email protected]
Malignant gliomas represent a difficult therapeutic challenge due to the invasive nature of the tumor and limited tumoral delivery of therapeutic agents. In this study, novel nano liposome carriers composed of sulfatides were developed for the glioma targeted delivery. Firstly, sulfatides-containing liposomes (SCLs) were found to interact with glioma cells specifically. The specific interactions between sulfatides and tenascin-c (TN-C), a glioma overexpressed protein, may have an important role. Secondly, the mechanism of intracellular delivery of SCLs was studied. SCLs were found to be effectively internalized in glioma cells by both clathrin-dependent and caveolae/lipids rafts pathways. Thirdly, doxorubicin (DOX) was effectively loaded into the SCLs to form a liposomal drug, SCL-DOX. SCL-DOX could effectively accumulate in the nuclei of glioma cells that resulted in superior in vitro cytotoxicity. In a subcutaneous xenografts animal model, SCL-DOX could effectively inhibit tumor growth and ...
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Noninvasive Differentiation Between Active and Healed Myocarditis by Cardiac Magnetic Resonance | JACC: Cardiovascular ImagingNoninvasive Differentiation Between Active and Healed Myocarditis by Cardiac Magnetic Resonance | JACC: Cardiovascular Imaging
Myocarditis is a common cardiac disease. It appears to be a major cause of sudden death, and may progress to chronic dilated cardiomyopathy. From the clinical point of view, there are several challenges unique to the management of patients with myocarditis. The first challenge is to establish the diagnosis of myocarditis, which is usually based on clinical, pathological, or a combination of diagnostic criteria. The second challenge is to follow the disease activity to identify patients who may be at risk of chronic dilated cardiomyopathy development, which seems to be associated with ongoing myocardial inflammation (1) and viral persistence (2).. Cardiac magnetic resonance (CMR) has recently emerged as a noninvasive tool to diagnose myocarditis (3-6), as well as to follow its course in living patients (3,7-9). Three features potentially associated with acute myocardial inflammation may be visualized by CMR: 1) tissue edema, which may result in an elevated T2 signal; 2) capillary leakage, which ...
Kelly Clarksons Fiance Brandon Blackstock Spoils Her on Birthday: Im So in Love Im Annoying MyselfKelly Clarkson's Fiance Brandon Blackstock Spoils Her on Birthday: 'I'm So in Love I'm Annoying Myself'
Im the happiest Ive ever been in my life, the former American Idol singer tweeted at her fans of pre-marital bliss with Brandon Blackstock
Chart Watch Extra: Idol vs. IdolChart Watch Extra: Idol vs. Idol
Whos the biggest recording star to come out of American Idol? I really think we should call it a tie. Carrie Underwood has sold more albums, but Kelly Clarkson has sold more individual songs. Just this week, Clarksons #1 smash Stronger (What Doesnt Kill You) pulled ahead of
Kelly Clarkson and Daughter River Rose Are Twins in Cute PhotosKelly Clarkson and Daughter River Rose Are Twins in Cute Photos
Kelly Clarksons daughter, River Rose, is the singers mini-me. See the cutest photos of her firstborn, whom she shares with husband Brandon Blackstock.
Come and meet the 2015 President-Elect Candidates! | AIChECome and meet the 2015 President-Elect Candidates! | AIChE
On Wednesday, August 20, the VLS will have the 2015 AIChE President-Elect Candidates, Greg Stephanopoulos and Tom Hanley, discuss their vision for AIChE.
GemcitabineGemcitabine
Targeted molecular therapy for neuroblastomaTargeted molecular therapy for neuroblastoma
Arturo PorzecanskiArturo Porzecanski
AnasarcaAnasarca
HematocritHematocrit
Gleichs syndromeGleich's syndrome
POEMS syndromePOEMS syndrome
List of diseases (C)List of diseases (C)
SCLSSCLS
DinutuximabDinutuximab
Cardiopulmonary bypassCardiopulmonary bypass
Clostridium sordelliiClostridium sordellii
LipopolysaccharideLipopolysaccharide
PolycythemiaPolycythemia
Interleukin 2Interleukin 2
Retinoic acid syndromeRetinoic acid syndrome
Urticarial syndromesUrticarial syndromes
Capillary leak syndromeCapillary leak syndrome
List of syndromesList of syndromes
Irvine-Gass syndromeIrvine-Gass syndrome
DoxorubicinDoxorubicin
Macular edemaMacular edema
Abdominal compartment syndromeAbdominal compartment syndrome
Respiratory diseaseRespiratory disease
Phenylmercury acetatePhenylmercury acetate
List of cutaneous conditionsList of cutaneous conditions
MicroangiopathyMicroangiopathy
Acute inhalation injuryAcute inhalation injury
SepsisSepsis
Intracranial aneurysmIntracranial aneurysm
Acute respiratory distress syndromeAcute respiratory distress syndrome
PolycythemiaPolycythemia
Damp (structural)Damp (structural)
Մասնակից:ArmArtificial Intelligence/Ավազարկղ - Վիքիպեդիա՝ ազատ հանրագիտարանՄասնակից:ArmArtificial Intelligence/Ավազարկղ - Վիքիպեդիա՝ ազատ հանրագիտարան
BleedingBleeding
Pancreatic cancerPancreatic cancer
LungLung
Pulmonary contusionPulmonary contusion
SepsisSepsis
Air conditioningAir conditioning
Venous ulcerVenous ulcer
GLUT1GLUT1
Water retention (medicine)Water retention (medicine)
Subarachnoid hemorrhageSubarachnoid hemorrhage
GlycolysisGlycolysis
Nephrotic syndromeNephrotic syndrome
தண்டுவட மரப்பு நோய் - தமிழ் விக்கிப்பீடியாதண்டுவட மரப்பு நோய் - தமிழ் விக்கிப்பீடியா
AneurysmAneurysm
Dengue feverDengue fever
LungLung
Mesenteric ischemiaMesenteric ischemia
Cerebrospinal fluidCerebrospinal fluid
Dengue fever - Simple English Wikipedia, the free encyclopediaDengue fever - Simple English Wikipedia, the free encyclopedia
DiseasesPhenomena and ProcessesInformation Science
Capillary Leak SyndromeCapillary PermeabilityHypoproteinemiaDictionaries, MedicalLymphoma, Large B-Cell, Diffuse
Systemic capillary leak syndrome - Mayo ClinicSystemic capillary leak syndrome - Mayo Clinic
Capillary leak syndrome - WikipediaCapillary leak syndrome - Wikipedia
CiNii 論文 - Systemic Capillary Leak Syndrome CiNii 論文 - Systemic Capillary Leak Syndrome
Systemic Capillary Leak SyndromeSystemic Capillary Leak Syndrome
The Systemic Capillary Leak Syndrome | Annals of Internal Medicine | American College of PhysiciansThe Systemic Capillary Leak Syndrome | Annals of Internal Medicine | American College of Physicians
The Systemic Capillary Leak Syndrome | Annals of Internal Medicine | American College of PhysiciansThe Systemic Capillary Leak Syndrome | Annals of Internal Medicine | American College of Physicians
A Remarkable Coexistence of Systemic Capillary Leak Syndrome and Diabetes in an 11-Year-Old Boy: A Case Report and Review of...A Remarkable Coexistence of Systemic Capillary Leak Syndrome and Diabetes in an 11-Year-Old Boy: A Case Report and Review of...
Capillary Leak Syndrome | definition of Capillary Leak Syndrome by Medical dictionaryCapillary Leak Syndrome | definition of Capillary Leak Syndrome by Medical dictionary
Systemic capillary leak syndrome revealing a diffuse large B-cell lymphomaSystemic capillary leak syndrome revealing a diffuse large B-cell lymphoma
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Systemic Capillary Leak Syndrome associated with hypovolemic shock and compartment syndrome. Use of transpulmonary...Systemic Capillary Leak Syndrome associated with hypovolemic shock and compartment syndrome. Use of transpulmonary...
Only 5 children in U.S. share rare disease of Danielson boy - News - The Bulletin - Norwich, CTOnly 5 children in U.S. share rare disease of Danielson boy - News - The Bulletin - Norwich, CT
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Metabolic serum profiles for patients receiving allogeneic stem cell transplantation: the pretransplant profile differs for...Metabolic serum profiles for patients receiving allogeneic stem cell transplantation: the pretransplant profile differs for...
Vaccine shows therapeutic promise against advanced melanomaVaccine shows therapeutic promise against advanced melanoma
Idiopathic systemic capillary leak syndromeIdiopathic systemic capillary leak syndrome
Capillary leak syndrome in dengue fever.Capillary leak syndrome in dengue fever.
Systemic capillary leak syndrome definition | Drugs.comSystemic capillary leak syndrome definition | Drugs.com
The Current Opinions of Capillary Leak SyndromeThe Current Opinions of Capillary Leak Syndrome
Capillary protein leak syndrome appears to explain fluid retention in cancer patients who receive docetaxel treatment.Capillary protein leak syndrome appears to explain fluid retention in cancer patients who receive docetaxel treatment.
Systemic Capillary Leak Syndrome Associated with Multiple Myeloma of IgG κTypeSystemic Capillary Leak Syndrome Associated with Multiple Myeloma of IgG κType
Idiopathic systemic capillary leak syndrome presenting as septic shock: A case reportIdiopathic systemic capillary leak syndrome presenting as septic shock: A case report
Systemic capillary leak syndrome | Genetic and Rare Diseases Information Center (GARD) - an NCATS ProgramSystemic capillary leak syndrome | Genetic and Rare Diseases Information Center (GARD) - an NCATS Program
Interleukin-11-induced capillary leak syndrome in primary hepatic carcinoma patients with thrombocytopenia. | CureHunterInterleukin-11-induced capillary leak syndrome in primary hepatic carcinoma patients with thrombocytopenia. | CureHunter
Systemic capillary leak syndrome | Genetic and Rare Diseases Information Center (GARD) - an NCATS ProgramSystemic capillary leak syndrome | Genetic and Rare Diseases Information Center (GARD) - an NCATS Program
Pneumotox » Drug » Chemotherapy, antineoplastic » X.c - Capillary leak syndrome (CLS)Pneumotox » Drug » Chemotherapy, antineoplastic » X.c - Capillary leak syndrome (CLS)
Idiopathic systemic capillary leak syndrome (Clarksons disease) - Minerva Medica 1999 October;90(10):391-6 - Minerva Medica -...Idiopathic systemic capillary leak syndrome (Clarkson's disease) - Minerva Medica 1999 October;90(10):391-6 - Minerva Medica -...
Antiphospholipids Syndrome Complicated by a Systemic Capillary Leak-Like Syndrome Treated With Steroids and Intravenous...Antiphospholipids Syndrome Complicated by a Systemic Capillary Leak-Like Syndrome Treated With Steroids and Intravenous...
Summary Safety Review - YONDELIS (trabectedin) - Assessing the Potential Risk of Fluid Leakage from Small Blood Vessels ...Summary Safety Review - YONDELIS (trabectedin) - Assessing the Potential Risk of Fluid Leakage from Small Blood Vessels ...
Filgrastim and pegfilgrastim: risk of capillary leak syndrome | Document Summary - Evidence Search - Search Engine for Evidence...Filgrastim and pegfilgrastim: risk of capillary leak syndrome | Document Summary - Evidence Search - Search Engine for Evidence...
Systemic capillary leak syndrome after granulocyte colony-stimulating factor (G-CSF). - Semantic ScholarSystemic capillary leak syndrome after granulocyte colony-stimulating factor (G-CSF). - Semantic Scholar
Systemic capillary leak syndrome should be considered in the differential diagnosis of multi-organ failure and hypovolemic...Systemic capillary leak syndrome should be considered in the differential diagnosis of multi-organ failure and hypovolemic...
JCDR - Idiopathic Systemic Capillary Leak Syndrome: A Diagnostic Challenge and Its ManagementJCDR - Idiopathic Systemic Capillary Leak Syndrome: A Diagnostic Challenge and Its Management
Health Sciences Research Commons - GW Research Days 2016 - Present: Fluctuating Monoclonal Gammopathy Protein levels in...Health Sciences Research Commons - GW Research Days 2016 - Present: Fluctuating Monoclonal Gammopathy Protein levels in...
https://www.medicalnewstoday.com/articles/320906.phphttps://www.medicalnewstoday.com/articles/320906.php
Function of Capillaries: Definition, Structure, Types, and ConditionsFunction of Capillaries: Definition, Structure, Types, and Conditions
DiseasesPhenomena and ProcessesInformation Science
Capillary Leak SyndromeCapillary PermeabilityHypoproteinemiaDictionaries, MedicalLymphoma, Large B-Cell, Diffuse
SCLSClarksonHypotensionLeakageHyperpermeabilityPulmonaryIdiopathicEdemaCompartmentPatientsRecurrentHemophagocytic lymphohistiocytosisDiseaseShockSymptomsCirculatoryPatientSecondaryReactionsWallsIdiopathic systemicAssociated with systemic capillarRisk of capillary leak synIncreased capillary permeabilityVascularMonoclonalAcute respiratCases of capillaryBlood vessels into your body's tissuesEndothelialSystemic capillary leakageHemolytic Uremic SClarkson'sEndotheliumARDSDengue feverTissuesCytokinesSevereSepsisPoresClinicalRhabdomyolysisLeakage syndromeOccurTiny blood vesselsTheophyllineAttacks
SCLS7
Clarkson2
Hypotension2
  • The abdomen, the central nervous system, and the organs (including the lungs) are typically spared, but the extravasation in the extremities is sufficiently massive to cause circulatory shock and compartment syndromes, with a dangerous hypotension (low blood pressure), hemoconcentration(thickening of the blood) and hypoalbuminemia (drop in albumin, a major protein) in the absence of other causes for such abnormalities. (wikipedia.org)
  • Pro-inflammatory cytokines acting on the vascular endothelium cause capillary leak that can ultimately result in hypotension with consequent multiorgan failure. (bmj.com)
Leakage2
Hyperpermeability1
Pulmonary1
Idiopathic1
Edema1
Compartment1
Patients2
Recurrent1
Hemophagocytic lymphohistiocytosis1
Disease1
  • Toxic shock syndrome (TSS) is a relatively rare but severe disease that is more common in children than adults and characterised by fever, erythematous rash and multiorgan failure. (bmj.com)
Shock1
Symptoms2
Circulatory1
  • Capillary leak syndrome is characterized by the escape of blood plasma through capillary walls, from the blood circulatory system to surrounding tissues, muscle compartments, organs or body cavities. (wikipedia.org)
Patient2
Secondary1
Reactions1
Walls1
  • One study reports that it is caused by chemicals in the body that damage or temporarily separate the cells lining the capillary walls. (mayoclinic.org)
Idiopathic systemic15
Associated with systemic capillar2
Risk of capillary leak syn4
  • Health Canada s safety review concluded that there is a potential risk of capillary leak syndrome with the use of Yondelis. (canada.ca)
  • Health Canada carried out a safety review to look into the potential risk of capillary leak syndrome with the use of Yondelis. (canada.ca)
  • Health Canada is recommending updates to the Canadian product information to include the potential risk of capillary leak syndrome with the use of Yondelis. (canada.ca)
  • Risk of capillary leak syndrome (CLS) and hemolytic uremic syndrome (HUS). (oncologynurseadvisor.com)
Increased capillary permeability2
Vascular8
Monoclonal5
Acute respirat4
  • Significant complications included 6 patients with acute respiratory distress syndrome, 28 patients with infectious complications, and 4 patients with anastomotic complications. (elsevier.com)
  • Acute respiratory distress syndrome (ARDS): Evaluate patients who develop fever, lung infiltrates, or respiratory distress. (nih.gov)
  • Acute respiratory distress syndrome (ARDS) is a rare complication of generalized pustular psoriasis (GPP). (scielo.br)
  • Acute respiratory distress syndrome (ARDS) has been reported in patients receiving filgrastim products. (pfizerpro.com)
Cases of capillary4
Blood vessels into your body's tissues1
Endothelial4
  • It is characterized by self-reversing episodes during which the endothelial cells which line the capillaries, usually of the extremities, separate for one to three days, causing a leakage of plasma mainly into the muscle compartments of the arms and legs. (wikipedia.org)
  • That's why the continuous capillaries in this area don't have any gaps between endothelial cells, and their surrounding basement membrane is also thicker. (healthline.com)
  • Loss of endothelial integrity promotes capillary leakage in numerous diseases, including sepsis, but there are no effective therapies for preserving endothelial barrier function. (pnas.org)
  • Scheinfeld N. Commentary on Degos disease: a C5b-9/interferon-α-mediated endotheliopathy syndrome by Magro et al: a reconsideration of Degos disease as hematologic or endothelial genetic disease. (medscape.com)
Systemic capillary leakage1
Hemolytic Uremic S3
  • Hemolytic Uremic Syndrome (HUS) is a condition that affects your blood cells and kidney and can be life threatening. (medicineshoppe.com)
  • Capillary leak syndrome (CLS) and hemolytic uremic syndrome (HUS), including life-threatening cases of each, have been reported among patients treated with LUMOXITI. (astrazeneca-us.com)
  • Hemolytic Uremic Syndrome (HUS), including life-threatening cases, occurred in patients receiving Lumoxiti. (centerwatch.com)
Clarkson's3
Endothelium2
ARDS1
  • ARDS can be caused by apulmonary capillary leak syndrome, an infection or by drugs hypersensivity reaction (methotrexate or acitretin) and it seems to be related to cytokines (interleukin 1, tumor necrosis factor α and interleukin 2). (scielo.br)
Dengue fever2
Tissues7
Cytokines1
  • The appearance of interleukin-2 receptor-bearing cells may be symptomatic of some immunological disturbance which also results in the secretion of cytokines which subsequently affect the capillaries. (readabstracts.com)
Severe2
  • Severe capillary leak syndrome with cardiac arrest triggered by influenza virus infection. (dbcls.jp)
  • Pregnancy was remarkable for severe twin-to-twin transfusion syndrome, of which she was the donor. (ispub.com)
Sepsis1
  • It is a phenomenon most commonly witnessed in sepsis, and less frequently in autoimmune diseases, differentiation syndrome, engraftment syndrome, hemophagocytic lymphohistiocytosis, the ovarian hyperstimulation syndrome, viral hemorrhagic fevers, and snakebite and ricin poisoning. (wikipedia.org)
Pores2
Clinical3
  • All clinical and laboratory findings supported autoinflammation as the underlying pathogenic mechanism of the syndrome. (ovid.com)
  • The data indicate that SCL-like syndrome can be considered a novel clinical syndrome, which can complicate APS. (ovid.com)
  • Rhabdomyolysis, which literally means striated muscle dissolution or disintegration, 1 is a potentially lethal clinical and biochemical syndrome. (aafp.org)
Rhabdomyolysis1
  • Rhabdomyolysis is a potentially life-threatening syndrome resulting from the breakdown of skeletal muscle fibers with leakage of muscle contents into the circulation. (aafp.org)
Leakage syndrome1
Occur2
Tiny blood vessels1
Theophylline1
Attacks1
Rareshare
Rareshare (rareshare.org)
Only 5 children in U.S. share rare disease of Danielson boy - News - The Bulletin - Norwich, CT
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Vaccine shows therapeutic promise against advanced melanoma
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Systemic Capillary Leak Syndrome associated with hypovolemic shock and compartment syndrome. Use of transpulmonary...
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Toxic shock syndrome: under-recognised and under-treated? | Archives of Disease in Childhood
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Https://www.medicalnewstoday.com/articles/320906.php
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Drug-Induced Pulmonary Toxicity: Practice Essentials, Background, Pathophysiology
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DailyMed - SORIATANE- acitretin capsule
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Search
Search (apps.who.int)
Capillary leak syndrome in dengue fever.
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Frontiers | Paroxysmal Permeability Disorders: Development of a Microfluidic Device to Assess Endothelial Barrier Function |...
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Characterization of Endothelial Dysfunction as a Function of Hyperaemia of the Brachial Artery During Cardiac Surgery - Full...
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Idiopathic systemic capillary leak syndrome (Clarkson's disease) - Minerva Medica 1999 October;90(10):391-6 - Minerva Medica -...
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The Systemic Capillary Leak Syndrome: A Case Series of 28 Patients From a European Registry | Annals of Internal Medicine |...
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