Capillaries: The minute vessels that connect the arterioles and venules.Electrophoresis, Capillary: A highly-sensitive (in the picomolar range, which is 10,000-fold more sensitive than conventional electrophoresis) and efficient technique that allows separation of PROTEINS; NUCLEIC ACIDS; and CARBOHYDRATES. (Segen, Dictionary of Modern Medicine, 1992)Capillary Action: A phenomenon in which the surface of a liquid where it contacts a solid is elevated or depressed, because of the relative attraction of the molecules of the liquid for each other and for those of the solid. (from McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Capillary Permeability: The property of blood capillary ENDOTHELIUM that allows for the selective exchange of substances between the blood and surrounding tissues and through membranous barriers such as the BLOOD-AIR BARRIER; BLOOD-AQUEOUS BARRIER; BLOOD-BRAIN BARRIER; BLOOD-NERVE BARRIER; BLOOD-RETINAL BARRIER; and BLOOD-TESTIS BARRIER. Small lipid-soluble molecules such as carbon dioxide and oxygen move freely by diffusion. Water and water-soluble molecules cannot pass through the endothelial walls and are dependent on microscopic pores. These pores show narrow areas (TIGHT JUNCTIONS) which may limit large molecule movement.Hemangioma, Capillary: A dull red, firm, dome-shaped hemangioma, sharply demarcated from surrounding skin, usually located on the head and neck, which grows rapidly and generally undergoes regression and involution without scarring. It is caused by proliferation of immature capillary vessels in active stroma, and is usually present at birth or occurs within the first two or three months of life. (Dorland, 27th ed)Capillary Resistance: The vascular resistance to the flow of BLOOD through the CAPILLARIES portions of the peripheral vascular bed.Capillary Electrochromatography: A separation technique which combines LIQUID CHROMATOGRAPHY and CAPILLARY ELECTROPHORESIS.Capillary Leak Syndrome: A condition characterized by recurring episodes of fluid leaking from capillaries into extra-vascular compartments causing hematocrit to rise precipitously. If not treated, generalized vascular leak can lead to generalized EDEMA; SHOCK; cardiovascular collapse; and MULTIPLE ORGAN FAILURE.Capillary Fragility: The susceptibility of CAPILLARIES, under conditions of increased stress, to leakage.Microcirculation: The circulation of the BLOOD through the MICROVASCULAR NETWORK.Retinal Vessels: The blood vessels which supply and drain the RETINA.Neovascularization, Physiologic: The development of new BLOOD VESSELS during the restoration of BLOOD CIRCULATION during the healing process.Capillary Tubing: Hollow cylindrical objects with an internal diameter that is small enough to fill by and hold liquids inside by CAPILLARY ACTION.Endothelium, Vascular: Single pavement layer of cells which line the luminal surface of the entire vascular system and regulate the transport of macromolecules and blood components.Corrosion Casting: A tissue preparation technique that involves the injecting of plastic (acrylates) into blood vessels or other hollow viscera and treating the tissue with a caustic substance. This results in a negative copy or a solid replica of the enclosed space of the tissue that is ready for viewing under a scanning electron microscope.Kidney Glomerulus: A cluster of convoluted capillaries beginning at each nephric tubule in the kidney and held together by connective tissue.Nails: The thin, horny plates that cover the dorsal surfaces of the distal phalanges of the fingers and toes of primates.Microscopic Angioscopy: The noninvasive microscopic examination of the microcirculation, commonly done in the nailbed or conjunctiva. In addition to the capillaries themselves, observations can be made of passing blood cells or intravenously injected substances. This is not the same as endoscopic examination of blood vessels (ANGIOSCOPY).Pericytes: Unique slender cells with multiple processes extending along the capillary vessel axis and encircling the vascular wall, also called mural cells. Pericytes are imbedded in the BASEMENT MEMBRANE shared with the ENDOTHELIAL CELLS of the vessel. Pericytes are important in maintaining vessel integrity, angiogenesis, and vascular remodeling.Pulmonary Circulation: The circulation of the BLOOD through the LUNGS.Pulmonary Wedge Pressure: The blood pressure as recorded after wedging a CATHETER in a small PULMONARY ARTERY; believed to reflect the PRESSURE in the pulmonary CAPILLARIES.Regional Blood Flow: The flow of BLOOD through or around an organ or region of the body.Chromatography, Gas: Fractionation of a vaporized sample as a consequence of partition between a mobile gaseous phase and a stationary phase held in a column. Two types are gas-solid chromatography, where the fixed phase is a solid, and gas-liquid, in which the stationary phase is a nonvolatile liquid supported on an inert solid matrix.Basement Membrane: A darkly stained mat-like EXTRACELLULAR MATRIX (ECM) that separates cell layers, such as EPITHELIUM from ENDOTHELIUM or a layer of CONNECTIVE TISSUE. The ECM layer that supports an overlying EPITHELIUM or ENDOTHELIUM is called basal lamina. Basement membrane (BM) can be formed by the fusion of either two adjacent basal laminae or a basal lamina with an adjacent reticular lamina of connective tissue. BM, composed mainly of TYPE IV COLLAGEN; glycoprotein LAMININ; and PROTEOGLYCAN, provides barriers as well as channels between interacting cell layers.Microscopy, Electron: Microscopy using an electron beam, instead of light, to visualize the sample, thereby allowing much greater magnification. The interactions of ELECTRONS with specimens are used to provide information about the fine structure of that specimen. In TRANSMISSION ELECTRON MICROSCOPY the reactions of the electrons that are transmitted through the specimen are imaged. In SCANNING ELECTRON MICROSCOPY an electron beam falls at a non-normal angle on the specimen and the image is derived from the reactions occurring above the plane of the specimen.Endothelium: A layer of epithelium that lines the heart, blood vessels (ENDOTHELIUM, VASCULAR), lymph vessels (ENDOTHELIUM, LYMPHATIC), and the serous cavities of the body.Endothelial Cells: Highly specialized EPITHELIAL CELLS that line the HEART; BLOOD VESSELS; and lymph vessels, forming the ENDOTHELIUM. They are polygonal in shape and joined together by TIGHT JUNCTIONS. The tight junctions allow for variable permeability to specific macromolecules that are transported across the endothelial layer.Arterioles: The smallest divisions of the arteries located between the muscular arteries and the capillaries.Venules: The minute vessels that collect blood from the capillary plexuses and join together to form veins.Vascular Endothelial Growth Factor A: The original member of the family of endothelial cell growth factors referred to as VASCULAR ENDOTHELIAL GROWTH FACTORS. Vascular endothelial growth factor-A was originally isolated from tumor cells and referred to as "tumor angiogenesis factor" and "vascular permeability factor". Although expressed at high levels in certain tumor-derived cells it is produced by a wide variety of cell types. In addition to stimulating vascular growth and vascular permeability it may play a role in stimulating VASODILATION via NITRIC OXIDE-dependent pathways. Alternative splicing of the mRNA for vascular endothelial growth factor A results in several isoforms of the protein being produced.Electrophoresis, Microchip: A highly miniaturized version of ELECTROPHORESIS performed in a microfluidic device.Microscopy, Video: Microscopy in which television cameras are used to brighten magnified images that are otherwise too dark to be seen with the naked eye. It is used frequently in TELEPATHOLOGY.Blood-Brain Barrier: Specialized non-fenestrated tightly-joined ENDOTHELIAL CELLS with TIGHT JUNCTIONS that form a transport barrier for certain substances between the cerebral capillaries and the BRAIN tissue.Ischemia: A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS, or an absence of BLOOD CIRCULATION.Glycocalyx: The carbohydrate-rich zone on the cell surface. This zone can be visualized by a variety of stains as well as by its affinity for lectins. Although most of the carbohydrate is attached to intrinsic plasma membrane molecules, the glycocalyx usually also contains both glycoproteins and proteoglycans that have been secreted into the extracellular space and then adsorbed onto the cell surface. (Alberts et al., Molecular Biology of the Cell, 3d ed, p502)Blood Flow Velocity: A value equal to the total volume flow divided by the cross-sectional area of the vascular bed.Muscle, Skeletal: A subtype of striated muscle, attached by TENDONS to the SKELETON. Skeletal muscles are innervated and their movement can be consciously controlled. They are also called voluntary muscles.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Granuloma, Pyogenic: A disorder of the skin, the oral mucosa, and the gingiva, that usually presents as a solitary polypoid capillary hemangioma often resulting from trauma. It is manifested as an inflammatory response with similar characteristics to those of a granuloma.Reproducibility of Results: The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.Hemodynamics: The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM.Lung: Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.Neovascularization, Pathologic: A pathologic process consisting of the proliferation of blood vessels in abnormal tissues or in abnormal positions.Blood Specimen Collection: The taking of a blood sample to determine its character as a whole, to identify levels of its component cells, chemicals, gases, or other constituents, to perform pathological examination, etc.Rats, Sprague-Dawley: A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.Veins: The vessels carrying blood away from the capillary beds.Oxygen: An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.Hematocrit: The volume of packed RED BLOOD CELLS in a blood specimen. The volume is measured by centrifugation in a tube with graduated markings, or with automated blood cell counters. It is an indicator of erythrocyte status in disease. For example, ANEMIA shows a low value; POLYCYTHEMIA, a high value.Diabetic Retinopathy: Disease of the RETINA as a complication of DIABETES MELLITUS. It is characterized by the progressive microvascular complications, such as ANEURYSM, interretinal EDEMA, and intraocular PATHOLOGIC NEOVASCULARIZATION.Microscopy, Electron, Scanning: Microscopy in which the object is examined directly by an electron beam scanning the specimen point-by-point. The image is constructed by detecting the products of specimen interactions that are projected above the plane of the sample, such as backscattered electrons. Although SCANNING TRANSMISSION ELECTRON MICROSCOPY also scans the specimen point by point with the electron beam, the image is constructed by detecting the electrons, or their interaction products that are transmitted through the sample plane, so that is a form of TRANSMISSION ELECTRON MICROSCOPY.Blood Vessels: Any of the tubular vessels conveying the blood (arteries, arterioles, capillaries, venules, and veins).Perfusion: Treatment process involving the injection of fluid into an organ or tissue.Blood-Air Barrier: The barrier between capillary blood and alveolar air comprising the alveolar EPITHELIUM and capillary ENDOTHELIUM with their adherent BASEMENT MEMBRANE and EPITHELIAL CELL cytoplasm. PULMONARY GAS EXCHANGE occurs across this membrane.Limit of Detection: Concentration or quantity that is derived from the smallest measure that can be detected with reasonable certainty for a given analytical procedure.Immunohistochemistry: Histochemical localization of immunoreactive substances using labeled antibodies as reagents.Skin: The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.Rats, Wistar: A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.Microvessels: The finer blood vessels of the vasculature that are generally less than 100 microns in internal diameter.Mesentery: A layer of the peritoneum which attaches the abdominal viscera to the ABDOMINAL WALL and conveys their blood vessels and nerves.Blood Pressure: PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.Cells, Cultured: Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.Pulmonary Diffusing Capacity: The amount of a gas taken up, by the pulmonary capillary blood from the alveolar gas, per minute per unit of average pressure of the gradient of the gas across the BLOOD-AIR BARRIER.Disease Models, Animal: Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.Pulmonary Edema: Excessive accumulation of extravascular fluid in the lung, an indication of a serious underlying disease or disorder. Pulmonary edema prevents efficient PULMONARY GAS EXCHANGE in the PULMONARY ALVEOLI, and can be life-threatening.Cattle: Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.Brain: The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.Pulmonary Alveoli: Small polyhedral outpouchings along the walls of the alveolar sacs, alveolar ducts and terminal bronchioles through the walls of which gas exchange between alveolar air and pulmonary capillary blood takes place.Erythrocytes: Red blood cells. Mature erythrocytes are non-nucleated, biconcave disks containing HEMOGLOBIN whose function is to transport OXYGEN.Kidney: Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.Glomerulonephritis: Inflammation of the renal glomeruli (KIDNEY GLOMERULUS) that can be classified by the type of glomerular injuries including antibody deposition, complement activation, cellular proliferation, and glomerulosclerosis. These structural and functional abnormalities usually lead to HEMATURIA; PROTEINURIA; HYPERTENSION; and RENAL INSUFFICIENCY.Lasers: An optical source that emits photons in a coherent beam. Light Amplification by Stimulated Emission of Radiation (LASER) is brought about using devices that transform light of varying frequencies into a single intense, nearly nondivergent beam of monochromatic radiation. Lasers operate in the infrared, visible, ultraviolet, or X-ray regions of the spectrum.Vascular Resistance: The force that opposes the flow of BLOOD through a vascular bed. It is equal to the difference in BLOOD PRESSURE across the vascular bed divided by the CARDIAC OUTPUT.Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)Vascular Endothelial Growth Factors: A family of angiogenic proteins that are closely-related to VASCULAR ENDOTHELIAL GROWTH FACTOR A. They play an important role in the growth and differentiation of vascular as well as lymphatic endothelial cells.Endothelial Growth Factors: These growth factors are soluble mitogens secreted by a variety of organs. The factors are a mixture of two single chain polypeptides which have affinity to heparin. Their molecular weight are organ and species dependent. They have mitogenic and chemotactic effects and can stimulate endothelial cells to grow and synthesize DNA. The factors are related to both the basic and acidic FIBROBLAST GROWTH FACTORS but have different amino acid sequences.Lymphatic System: A system of organs and tissues that process and transport immune cells and LYMPH.Borates: Inorganic or organic salts and esters of boric acid.Angiogenesis Inducing Agents: Agents that induce or stimulate PHYSIOLOGIC ANGIOGENESIS or PATHOLOGIC ANGIOGENESIS.Dogs: The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)Cerebrovascular Circulation: The circulation of blood through the BLOOD VESSELS of the BRAIN.Microfluidics: The study of fluid channels and chambers of tiny dimensions of tens to hundreds of micrometers and volumes of nanoliters or picoliters. This is of interest in biological MICROCIRCULATION and used in MICROCHEMISTRY and INVESTIGATIVE TECHNIQUES.Blood Volume: Volume of circulating BLOOD. It is the sum of the PLASMA VOLUME and ERYTHROCYTE VOLUME.Mice, Inbred C57BLOxygen Consumption: The rate at which oxygen is used by a tissue; microliters of oxygen STPD used per milligram of tissue per hour; the rate at which oxygen enters the blood from alveolar gas, equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body. (Stedman, 25th ed, p346)Antigens, CD31: Cell adhesion molecules present on virtually all monocytes, platelets, and granulocytes. CD31 is highly expressed on endothelial cells and concentrated at the junctions between them.Gas Chromatography-Mass Spectrometry: A microanalytical technique combining mass spectrometry and gas chromatography for the qualitative as well as quantitative determinations of compounds.Rabbits: The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.Fovea Centralis: An area approximately 1.5 millimeters in diameter within the macula lutea where the retina thins out greatly because of the oblique shifting of all layers except the pigment epithelium layer. It includes the sloping walls of the fovea (clivus) and contains a few rods in its periphery. In its center (foveola) are the cones most adapted to yield high visual acuity, each cone being connected to only one ganglion cell. (Cline et al., Dictionary of Visual Science, 4th ed)Models, Cardiovascular: Theoretical representations that simulate the behavior or activity of the cardiovascular system, processes, or phenomena; includes the use of mathematical equations, computers and other electronic equipment.Lymphokines: Soluble protein factors generated by activated lymphocytes that affect other cells, primarily those involved in cellular immunity.Fluorescein Angiography: Visualization of a vascular system after intravenous injection of a fluorescein solution. The images may be photographed or televised. It is used especially in studying the retinal and uveal vasculature.Pressure: A type of stress exerted uniformly in all directions. Its measure is the force exerted per unit area. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Rats, Inbred Strains: Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding.Buffers: A chemical system that functions to control the levels of specific ions in solution. When the level of hydrogen ion in solution is controlled the system is called a pH buffer.Coronary Vessels: The veins and arteries of the HEART.Complement C4b: The large fragment formed when COMPLEMENT C4 is cleaved by COMPLEMENT C1S. The membrane-bound C4b binds COMPLEMENT C2A, a SERINE PROTEASE, to form C4b2a (CLASSICAL PATHWAY C3 CONVERTASE) and subsequent C4b2a3b (CLASSICAL PATHWAY C5 CONVERTASE).Serum Albumin, Radio-Iodinated: Normal human serum albumin mildly iodinated with radioactive iodine (131-I) which has a half-life of 8 days, and emits beta and gamma rays. It is used as a diagnostic aid in blood volume determination. (from Merck Index, 11th ed)Arteriovenous Anastomosis: A vessel that directly interconnects an artery and a vein, and that acts as a shunt to bypass the capillary bed. Not to be confused with surgical anastomosis, nor with arteriovenous fistula.

VEGF is required for growth and survival in neonatal mice. (1/3987)

We employed two independent approaches to inactivate the angiogenic protein VEGF in newborn mice: inducible, Cre-loxP- mediated gene targeting, or administration of mFlt(1-3)-IgG, a soluble VEGF receptor chimeric protein. Partial inhibition of VEGF achieved by inducible gene targeting resulted in increased mortality, stunted body growth and impaired organ development, most notably of the liver. Administration of mFlt(1-3)-IgG, which achieves a higher degree of VEGF inhibition, resulted in nearly complete growth arrest and lethality. Ultrastructural analysis documented alterations in endothelial and other cell types. Histological and biochemical changes consistent with liver and renal failure were observed. Endothelial cells isolated from the liver of mFlt(1-3)-IgG-treated neonates demonstrated an increased apoptotic index, indicating that VEGF is required not only for proliferation but also for survival of endothelial cells. However, such treatment resulted in less significant alterations as the animal matured, and the dependence on VEGF was eventually lost some time after the fourth postnatal week. Administration of mFlt(1-3)-IgG to juvenile mice failed to induce apoptosis in liver endothelial cells. Thus, VEGF is essential for growth and survival in early postnatal life. However, in the fully developed animal, VEGF is likely to be involved primarily in active angiogenesis processes such as corpus luteum development.  (+info)

Microvessels from Alzheimer's disease brains kill neurons in vitro. (2/3987)

Understanding the pathogenesis of Alzheimer's disease is of widespread interest because it is an increasingly prevalent disorder that is progressive, fatal, and currently untreatable. The dementia of Alzheimer's disease is caused by neuronal cell death. We demonstrate for the first time that blood vessels isolated from the brains of Alzheimer's disease patients can directly kill neurons in vitro. Either direct co-culture of Alzheimer's disease microvessels with neurons or incubation of cultured neurons with conditioned medium from microvessels results in neuronal cell death. In contrast, vessels from elderly nondemented donors are significantly (P<0.001) less lethal and brain vessels from younger donors are not neurotoxic. Neuronal killing by either direct co-culture with Alzheimer's disease microvessels or conditioned medium is dose- and time-dependent. Neuronal death can occur by either apoptotic or necrotic mechanisms. The microvessel factor is neurospecific, killing primary cortical neurons, cerebellar granule neurons, and differentiated PC-12 cells, but not non-neuronal cell types or undifferentiated PC-12 cells. Appearance of the neurotoxic factor is decreased by blocking microvessel protein synthesis with cycloheximide. The neurotoxic factor is soluble and likely a protein, because its activity is heat labile and trypsin sensitive. These findings implicate a novel mechanism of vascular-mediated neuronal cell death in Alzheimer's disease.  (+info)

Angiosarcomas express mixed endothelial phenotypes of blood and lymphatic capillaries: podoplanin as a specific marker for lymphatic endothelium. (3/3987)

Angiosarcomas apparently derive from blood vessel endothelial cells; however, occasionally their histological features suggest mixed origin from blood and lymphatic endothelia. In the absence of specific positive markers for lymphatic endothelia the precise distinction between these components has not been possible. Here we provide evidence by light and electron microscopic immunohistochemistry that podoplanin, a approximately 38-kd membrane glycoprotein of podocytes, is specifically expressed in the endothelium of lymphatic capillaries, but not in the blood vasculature. In normal skin and kidney, podoplanin colocalized with vascular endothelial growth factor receptor-3, the only other lymphatic marker presently available. Complementary immunostaining of blood vessels was obtained with established endothelial markers (CD31, CD34, factor VIII-related antigen, and Ulex europaeus I lectin) as well as podocalyxin, another podocytic protein that is also localized in endothelia of blood vessels. Podoplanin specifically immunolabeled endothelia of benign tumorous lesions of undisputed lymphatic origin (lymphangiomas, hygromas) and was detected there as a 38-kd protein by immunoblotting. As paradigms of malignant vascular tumors, poorly differentiated (G3) common angiosarcomas (n = 8), epitheloid angiosarcomas (n = 3), and intestinal Kaposi's sarcomas (n = 5) were examined for their podoplanin content in relation to conventional endothelial markers. The relative number of tumor cells expressing podoplanin was estimated and, although the number of cases in this preliminary study was limited to 16, an apparent spectrum of podoplanin expression emerged that can be divided into a low-expression group in which 0-10% of tumor cells contained podoplanin, a moderate-expression group with 30-60% and a high-expression group with 70-100%. Ten of eleven angiosarcomas and all Kaposi's sarcomas showed mixed expression of both lymphatic and blood vascular endothelial phenotypes. By double labeling, most podoplanin-positive tumor cells coexpressed endothelial markers of blood vessels, whereas few tumor cells were positive for individual markers only. From these results we conclude that (1) podoplanin is a selective marker of lymphatic endothelium; (2) G3 angiosarcomas display a quantitative spectrum of podoplanin-expressing tumor cells; (3) in most angiosarcomas, a varying subset of tumor cells coexpresses podoplanin and endothelial markers of blood vessels; and (4) all endothelial cells of Kaposi's sarcomas expressed the lymphatic marker podoplanin.  (+info)

Microvascular function relates to insulin sensitivity and blood pressure in normal subjects. (4/3987)

BACKGROUND: A strong but presently unexplained inverse association between blood pressure and insulin sensitivity has been reported. Microvascular vasodilator capacity may be a common antecedent linking insulin sensitivity to blood pressure. To test this hypothesis, we studied 18 normotensive and glucose-tolerant subjects showing a wide range in insulin sensitivity as assessed with the hyperinsulinemic, euglycemic clamp technique. METHODS AND RESULTS: Blood pressure was measured by 24-hour ambulatory blood pressure monitoring. Videomicroscopy was used to measure skin capillary density and capillary recruitment after arterial occlusion. Skin blood flow responses after iontophoresis of acetylcholine and sodium nitroprusside were evaluated by laser Doppler flowmetry. Insulin sensitivity correlated with 24-hour systolic blood pressure (24-hour SBP; r=-0.50, P<0.05). Capillary recruitment and acetylcholine-mediated vasodilatation were strongly and positively related to insulin sensitivity (r=0.84, P<0.001; r=0.78, P<0.001, respectively), and capillary recruitment was inversely related to 24-hour SBP (r=-0.53, P<0.05). Waist-to-hip ratio showed strong associations with insulin sensitivity, blood pressure, and the measures of microvascular function but did not confound the associations between these variables. Subsequent regression analysis showed that the association between insulin sensitivity and blood pressure was not independent of the estimates of microvascular function, and part of the variation in both blood pressure (R2=38%) and insulin sensitivity (R2=71%) could be explained by microvascular function. CONCLUSIONS: Insulin sensitivity and blood pressure are associated well within the physiological range. Microvascular function strongly relates to both, consistent with a central role in linking these variables.  (+info)

Endothelin up-regulation and localization following renal ischemia and reperfusion. (5/3987)

BACKGROUND: Endothelin (ET), a potent vasoconstrictor, is known to play a role in ischemic acute renal failure. Although preproET-1 (ppET-1) mRNA is known to be up-regulated following ischemia/reperfusion injury, it has not been determined which component of the injury (ischemia or reperfusion) leads to initial gene up-regulation. Likewise, although ET-1 peptide expression has been localized in the normal kidney, its expression pattern in the ischemic kidney has not been determined. Therefore, the purpose of this study was twofold: (a) to determine whether ischemia alone or ischemia plus reperfusion is required for the up-regulation of ppET-1 mRNA to occur, and (b) to localize ET-1 peptide expression following ischemia in the rat kidney to clarify better the role of ET in the pathophysiology of ischemia-induced acute renal failure. METHODS: Male Lewis rats underwent clamping of the right renal vascular pedicle for either 30 minutes of ischemia (group 1), 60 minutes of ischemia (group 2), 30 minutes of ischemia followed by 30 minutes of reperfusion (group 3), or 60 minutes of ischemia followed by three hours of reperfusion (group 4). The contralateral kidney acted as a control. ppET-1 mRNA up-regulation and ET-1 peptide expression were examined using the reverse transcription-polymerase chain reaction and immunohistochemistry, respectively. RESULTS: Reverse transcription-polymerase chain reaction yielded a control (nonischemic) value of 0.6 +/- 0.2 densitometric units (DU) of ppET-1 mRNA in the kidney. Group 1 levels (30 min of ischemia alone) were 1.8 +/- 0.4 DU, a threefold increase (P < 0.05). Group 2 levels (60 min of ischemia alone) increased almost six times above baseline, 3.5 +/- 0.2 DU (P < 0.01), whereas both group 3 and group 4 (ischemia plus reperfusion) did not experience any further significant increases in mRNA levels (1.9 +/- 0.4 DU and 2.8 +/- 0.6 DU, respectively) beyond levels in group 1 or 2 animals subjected to similar ischemic periods. ET-1 peptide expression in the ischemic kidneys was significantly increased over controls and was clearly localized to the endothelium of the peritubular capillary network of the kidney. CONCLUSIONS: Initial ET-1 gene up-regulation in the kidney occurs secondary to ischemia, but reperfusion most likely contributes to sustaining this up-regulation. The marked increase of ET-1 in the peritubular capillary network suggests that ET-induced vasoconstriction may have a pathophysiological role in ischemic acute tubular necrosis.  (+info)

Inhibition of effects of flow on potassium permeability in single perfused frog mesenteric capillaries. (6/3987)

1. We have investigated the effects of various potential inhibitors on flow-dependent K+ permeability (PK) of single perfused mesenteric microvessels in pithed frogs. 2. Neither superfusion with a nitric oxide synthase inhibitor, NG-monomethyl-L-arginine (10 or 100 micromol l-1), nor the addition of indomethacin (30 micromol l-1) to both perfusate and superfusate reduced the positive correlation between PK and flow velocity (U). 3. In the presence of agents known to raise intracellular levels of adenosine 3',5'-cyclic monophosphate (noradrenaline, 8-bromo-cAMP and a combination of forskolin and rolipram) the slope of the relation between PK and U was no longer significant, so that PK was no longer flow dependent. 4. These results confirm that the flow dependence of PK is a biological process and not an artefact of measurement and suggest a role for intracellular cAMP rather than nitric oxide or prostacyclin in the flow-dependent modulation of PK in frog mesenteric microvessels.  (+info)

Polyol formation and NADPH-dependent reductases in dog retinal capillary pericytes and endothelial cells. (7/3987)

PURPOSE: Dogs fed a diet containing 30% galactose experience retinal vascular changes similar to those in human diabetic retinopathy, with selective pericyte loss as an initial lesion. In the present study the relationship among reduced nicotinamide adenine dinucleotide phosphate (NADPH)-dependent reductases, polyol formation, and flux through the polyol pathway in cultured dog retinal capillary cells were investigated. METHODS: Pericytes and endothelial cells were cultured from retina of beagle dogs. NADPH-dependent reductases were characterized by chromatofocusing after gel filtration. Sugars in cultured cells were analyzed by gas chromatography, and flux through the polyol pathway was investigated by 19F nuclear magnetic resonance (NMR) with 3-fluoro-3-deoxy-D-glucose (3FG) as a substrate. The presence of aldose reductase and sorbitol dehydrogenase in these cells was examined by northern blot analysis. RESULTS: Two distinct peaks corresponding to aldose reductase and aldehyde reductase, the latter being dominant, were observed in pericytes by chromatofocusing. Culture in medium containing either 10 mM D-galactose or 30 mM D-glucose resulted in the accumulation of sugar alcohol in pericytes that was markedly reduced by aldose reductase inhibitors. 19F NMR spectra obtained from pericytes cultured for 5 days in medium containing 2 mM 3FG displayed the marked accumulation of 3-fluoro-deoxysorbitol but not 3-fluoro-deoxyfructose. No 3FG metabolism was observed in similarly cultured endothelial cells. With northern blot analysis, aldose reductase was detected in pericytes but not in endothelial cells. Sorbitol dehydrogenase was below the detectable limit in pericytes and endothelial cells. CONCLUSIONS: Aldose, aldehyde, and glyceraldehyde reductases are present in dog retinal capillary pericytes, with aldehyde reductase being the major reductase present. Polyol accumulation easily occurs in pericytes but not in endothelial cells.  (+info)

VEGF deprivation-induced apoptosis is a component of programmed capillary regression. (8/3987)

The pupillary membrane (PM) is a transient ocular capillary network, which can serve as a model system in which to study the mechanism of capillary regression. Previous work has shown that there is a tight correlation between the cessation of blood flow in a capillary segment and the appearance of apoptotic capillary cells throughout the segment. This pattern of cell death is referred to as synchronous apoptosis (Lang, R. A., Lustig, M., Francois, F., Sellinger, M. and Plesken, H. (1994) Development 120, 3395-3404; Meeson, A., Palmer, M., Calfon, M. and Lang, R. A. (1996) Development 122, 3929-3938). In the present study, we have investigated whether the cause of synchronous apoptosis might be a segmental deficiency of either oxygen or a survival factor. Labeling with the compound EF5 in a normal PM indicated no segmental hypoxia; this argued that oxygen deprivation was unlikely to be the cause of synchronous apoptosis. When rat plasma was used as a source of survival factors in an in vitro PM explant assay, inhibition of vascular endothelial growth factor (VEGF) all but eliminated the activity of plasma in suppressing apoptosis. This argued that VEGF was an important plasma survival factor. Furthermore, inhibition of VEGF in vivo using fusion proteins of the human Flk-1/KDR receptor resulted in a significantly increased number of capillaries showing synchronous apoptosis. This provides evidence that VEGF is necessary for endothelial cell survival in this system and in addition, that VEGF deprivation mediated by flow cessation is a component of synchronous apoptosis.  (+info)

*Peritubular capillaries

... surround the proximal and distal tubules, as well as the loop of Henle, where they are known as vasa ... The ions that need to be excreted as waste are secreted from the capillaries into the nephron to be sent towards the bladder ... Ions and minerals that need to be saved in the body are reabsorbed into the peritubular capillaries through active transport, ... Movement of water into the peritubular capillaries is due to the loss of water from the glomerulus during filtration, which ...

*Capillary

Sinusoidal capillaries (also known as a discontinuous capillary) are a special type of open-pore capillary, that have larger ... Individual capillaries are part of capillary bed, an interweaving network of capillaries supplying tissues and organs. The more ... Lymph capillaries have a greater internal oncotic pressure than blood capillaries, due to the greater concentration of plasma ... Lymphatic capillaries are slightly larger in diameter than blood capillaries, and have closed ends (unlike the blood ...

*Lymph capillary

Lymph capillaries or lymphatic capillaries are tiny, thin-walled vessels located in the spaces between cells (except in the ... Lymphatic capillaries are slightly larger in diameter than blood capillaries, and have closed ends (unlike the loop structure ... Lymph capillaries have a greater internal oncotic pressure than blood capillaries, due to the greater concentration of plasma ... and interstitial fluid enters the lymphatic capillary. When pressure is greater inside the lymphatic capillary, the cells ...

*Capillary refill

... time (CRT) is defined as the time taken for color to return to an external capillary bed after pressure is ... Normal capillary refill time is usually less than 2 seconds. In newborn infants, capillary refill time can be measured by ... Capillary nail refill test Krzysztof S Strozik; Clarissa H Pieper; Jacques Roller (1997-01-13). "Capillary refilling time in ... The upper normal limit for capillary refill in newborns is 3 seconds. Capillary refill time can also be assessed in animals by ...

*Capillary wave

... s are common in nature, and are often referred to as ripples. The wavelength of capillary waves in water is ... Capillary action Dispersion (water waves) Fluid pipe Ocean surface wave Thermal capillary wave Two-phase flow Wave-formed ... A capillary wave is a wave traveling along the phase boundary of a fluid, whose dynamics and phase velocity are dominated by ... Shorter (large k) waves (e.g. 2 mm for the water-air interface), which are proper capillary waves, do the opposite: an ...

*Capillary hemangioma

... is a vascular anomaly. Capillary hemangiomas occur 5 times more often in female infants than in males, and ... A capillary hemangioma (also known as an Infantile hemangioma, Strawberry hemangioma, and Strawberry nevus) is the most common ... Oral propranolol appears to be the most effective treatment for reducing the size of capillary hemangiomas in children and is ...

*Capillary condensation

Hysteresis in capillary condensation has been shown to be minimized at higher temperatures. Capillary condensation in pores ... For example, if a capillary's radius increases sharply, then capillary condensation (adsorption) will cease until an ... A capillary does not necessarily have to be a tubular, closed shape, but can be any confined space with respect to its ... Capillary condensation is the "process by which multilayer adsorption from the vapor [phase] into a porous medium proceeds to ...

*Capillary electrophoresis

Other capillaries including Teflon capillaries also exhibit electroosmotic flow. The EOF of these capillaries is probably the ... Sample is introduced into the capillary via capillary action, pressure, siphoning, or electrokinetically, and the capillary is ... Detection occurs via fluorescence through a window etched in the capillary. Both single-capillary and capillary-array ... Such capillary array electrophoresis (CAE) instruments with 16 or 96 capillaries are used for medium- to high-throughput ...

*Capillary electrochromatography

The capillary is packed with stationary phase. To introduce the sample, the capillary inlet is placed into a vial containing ... In capillary electrochromatography capillaries, packed with HPLC stationary phase, are subjected to a high voltage. Separation ... The components of a capillary electrochromatograph are a sample vial, source and destination vials, a packed capillary, ... sample is introduced into the capillary via capillary action, pressure, or siphoning). The migration of the analytes is then ...

*Capillary (disambiguation)

A capillary is a small blood vessel or any small diameter tube. Capillary may also refer to: Capillary length, a characteristic ... length scale in fluid mechanics Capillary action, the drawing of liquid into a tube or porous material Capillary ... electrophoresis, the separation of charged species by voltage applied to a small tube Capillary wave, is a liquid surface wave ...

*Capillary Technologies

"Sequoia - Capillary". Mishra, Pankaj. "With $4M In Fresh Funding From Amex Ventures, Capillary Wants to be Salesforce Of Social ... "Capillary takes over ecommerce platform - Times of India". The Times of India. Retrieved 2016-12-07. "Capillary Technologies ... In June 2013 Harvard Business Review used Capillary as a Case for reverse Innovation in Tech Startups. In July 2016, Capillary ... In September 2015, Capillary acquired an eCommerce software platform MartJack. In October 2016, Capillary acquired SellerWorx, ...

*Capillary fringe

The capillary fringe is the subsurface layer in which groundwater seeps up from a water table by capillary action to fill pores ... This saturated portion of the capillary fringe is less than total capillary rise because of the presence of a mix in pore size ... Capillary action supports a vadose zone above the saturated base within which water content decreases with distance above the ... Others define the capillary fringe as including both the tension-saturated and unsaturated portions. This is the preferred ...

*Capillary pressure

... can also be utilized to block fluid flow in a microfluidic device. The capillary pressure in a microchannel ... Capillary pressure formulas are derived from the pressure relationship between two fluid phases in a capillary tube in ... see capillary), resulting from the interactions of forces between the fluids and solid walls of the tube. Capillary pressure ... is the wetting angle of the liquid on the surface of the capillary The force down formula for capillary pressure is seen as: p ...

*Capillary length

For a soap bubble in air, the capillary length is around 4 meters (13 feet). A capillary surface that has a characteristic ... The capillary length is defined as: λ c = γ ρ g {\displaystyle \lambda _{c}={\sqrt {\frac {\gamma }{\rho g}}}} , where g {\ ... In fluid mechanics, capillary length is a characteristic length scale for an interface between two fluids which is subject both ... A sessile drop whose largest dimension is smaller than the capillary length, for example, will take the shape of spherical cap ...

*Capillary surface

Capillary pressure Surface energy Surface tension Capillary bridges Robert Finn (1999). "Capillary Surface Interfaces" (PDF). ... where both flow and static configuration are often dominated by capillary effects. The defining equation for a capillary ... In particular, static capillary surfaces with gravity absent have constant mean curvature, so that a minimal surface is a ... In a capillary tube, for example, implementing the contact angle boundary condition will yield a unique solution for exactly ...

*Luggin capillary

A Luggin capillary (also Luggin probe, Luggin tip, or Luggin-Haber capillary) is a small tube that is used in electrochemistry ... The capillary defines a clear sensing point for the reference electrode near the working electrode. This is in contrast to the ... "Luggin's capillary in studying the effect of electrochemical reaction on mechanical properties of solid surfaces", Journal of ... "Design of a single-unit Haber-Luggin capillary/dual reference-electrode system", Curr. Sep., 13 (2) CS1 maint: Multiple names: ...

*Capillary aneurysms

... are flesh colored solitary lesions, resembling an intradermal nevus, which may suddenly grow larger and ...

*Capillary number

... flow in porous media is dominated by capillary forces whereas for high capillary number the capillary forces are negligible ... The capillary number is a dimensionless quantity, hence its value does not depend on the system of units. For low capillary ... The capillary number is defined as: C a = μ V σ {\displaystyle \mathrm {Ca} ={\frac {\mu V}{\sigma }}} where µ is the dynamic ... In fluid dynamics, the capillary number (Ca) represents the relative effect of viscous forces versus surface tension acting ...

*Capillary flow porometry

In capillary flow porometry an inert gas is used to displace a liquid, which is in the pores. The pressure required to empty ... Capillary flow porometry, also known as porometry, is a characterization technique based on the displacement of a wetting ... In order to measure the pore size by capillary flow porometry it is necessary to impregnate the samples with a wetting liquid. ... In capillary flow porometry, in opposition to mercury intrusion porosimetry, the wetting liquid enters spontaneously the pores ...

*Macrocephaly-capillary malformation

In January 2012, a paper proposed new names for the syndrome: megalencephaly-capillary malformation or megalencephaly-capillary ... Macrocephaly-capillary malformation (M-CM) is a multiple malformation syndrome causing abnormal body and head overgrowth and ... A new name, macrocephaly-capillary malformation, abbreviated M-CM, was recommended in 2007. This new name was chosen to more ... Sep 2009). "Tetralogy of Fallot associated with macrocephaly-capillary malformation syndrome: a case report and review of the ...

*Pulmonary capillary hemangiomatosis

... (PCH) is a disease affecting the blood vessels of the lungs, where abnormal capillary ... Pulmonary capillary hemangiomatosis patients, families, and caregivers are encouraged to join the Registry NIH Rare Lung ... Masur Y, Remberger K, Hoefer M (1996). "Pulmonary capillary hemangiomatosis as a rare cause of pulmonary hypertension". Pathol ... El-Gabaly M, Farver CF, Budev MA, Mohammed TL (2007). "Pulmonary capillary hemangiomatosis imaging findings and literature ...

*Capillary leak syndrome

... is characterized by the escape of blood plasma through capillary walls, from the blood circulatory ... Systemic capillary leak syndrome (SCLS, or Clarkson's disease), or primary capillary leak syndrome, is a rare, grave and ... can also cause capillary leaks. These conditions and factors are sources of secondary capillary leak syndrome. ... It is characterized by self-reversing episodes during which the endothelial cells which line the capillaries, usually of the ...

*Alveolar capillary dysplasia

... (ACD, sometimes denoted ACDMPV when including misalignment of the pulmonary veins) is a type of ... Sirkin W, O'Hare BP, Cox PN, Perrin D, Cutz E, Silver MM (1997). "Alveolar capillary dysplasia: lung biopsy diagnosis, nitric ... It is a very rare congenital malformation involving abnormal development of the capillary vascular system around the alveoli of ... "Genomic and genic deletions of the FOX gene cluster on 16q24.1 and inactivating mutations of FOXF1 cause alveolar capillary ...

*Thermal capillary wave

Capillary wave theory (CWT) is a classic account of how thermal fluctuations distort an interface. It starts from some ... Thermal motion is able to produce capillary waves at the molecular scale. At this scale, gravity and hydrodynamics can be ... 2). J.S. Rowlinson and B. Widom "Molecular theory of capillarity 2002 capillary wave. ...

*Kinetic capillary electrophoresis

... or KCE is capillary electrophoresis of molecules that interact during electrophoresis. KCE ... the way interacting molecules enter and exit the capillary. Several KCE methods were described: non-equilibrium capillary ... Petrov A, Okhonin V, Berezovski M, Krylov SN (Dec 2005). "Kinetic capillary electrophoresis (KCE): a conceptual platform for ... Okhonin V, Berezovski M, Krylov SN (Jun 2004). "Sweeping capillary electrophoresis: a non-stopped-flow method for measuring ...
Blood Capillary Function - See more about Blood Capillary Function, blood capillaries in skin function, blood capillaries structure and function, blood capillary function, blood capillary tube function, capillaries blood cell function, capillary blood vessel function, function of blood capillary, function of blood capillary in skin, function of blood capillary in villi
Sanger Sequencing - Capillary Lengths - posted in Bioinformatics and Biostatistics: Dear all We had an ABI 3130 sequence analyzer, and I was just wondering how do the different capillary lengths (36cm and 50cm) differ? Do they have anything to do with the read lengths? Thanks
Looking for blood capillary? Find out information about blood capillary. microscopic blood vessel, smallest unit of the circulatory system circulatory system, group of organs that transport blood and the substances it carries to... Explanation of blood capillary
ABSTRACT: In order to study the neonatal microcirculation, the capillary hemodynamics in skin was investigated in 43 full-term infants 2-7 days after birth. The nailfold capillaries of the thumb were visualized by means of television microscopy and the capillary blood cell velocity (CBV) was videophotometrically quantified in 107 microvessels. The skin temperature, mean arterial blood pressure, and heel puncture hematocrit were measured simultaneously to evaluate any relation with the CBV. The mean CBV in all infants was 0.38 ± 0.21 mm/s, with a range of 0.04 to 1.2 mm/s in individual capillaries. There was no correlation between CBV and skin temperature (27-33° C), mean arterial blood pressure (44-68 mm Hg), or postnatal age. However, a significant correlation was found between the log CBV and the skin prick hematocrit (r = −0.64, p | 0.001). It is concluded that the mean CBV during the 1st wk of life is not significantly different from the capillary velocity reported in adults. Normal variations
A multiple capillary analyzer allows detection of light from multiple capillaries with a reduced number of interfaces through which light must pass in detecting light emitted from a sample being analyzed, using a modified sheath flow cuvette. A linear or rectangular array of capillaries is introduced into a rectangular flow chamber. Sheath fluid draws individual sample streams through the cuvette. The capillaries are closely and evenly spaced and held by a transparent retainer in a fixed position in relation to an optical detection system. Collimated sample excitation radiation is applied simultaneously across the ends of the capillaries in the retainer. Light emitted from the excited sample is detected by the optical detection system. The retainer is provided by a transparent chamber having inward slanting end walls. The capillaries are wedged into the chamber. One sideways dimension of the chamber is equal to the diameter of the capillaries and one end to end dimension varies from, at the top of the
For centuries it has been known that wetting liquids penetrate porous materials if the pores are sufficiently small. In some cases the liquid penetration is desired, like in kitchen paper or diapers, in other systems the penetration should be minimised or avoided, like in water repellent textiles or paper printing. Either way capillary flow has been studied extensively starting from smooth to rough surfaces and from single capillaries to porous systems. However, one field, which is lacking attention is the behaviour of capillary flow in porous gels. How does a semi-solid material influence capillary flow? Possible applications could be to absorb solutes or cell solutions in porous gels with the aim to get an even distribution of those. In this thesis alginate and agarose gels are used to study capillary flow. A thorough study of the gel characteristics including rheology measurements and investigation of the microstructure using two different gelation mechanisms gave the basis to study capillary action
Recent studies have revealed that functional hyperemia is initiated in capillaries (14, 15) and that RBCs themselves can act as oxygen-sensing regulators to control capillary RBC velocity in response to local PO2 changes (15). However, the underlying mechanisms of how PO2 could modulate RBC velocity in capillaries are unknown. Experimental findings presented here implicate that deoxyHb-band 3 interactions in RBCs are the molecular switch that responds to local PO2 changes and controls RBC deformability and consequently RBC capillary velocity. Evidently, we showed that (i) while ex vivo capillary velocity and deformation of mRBC-WT and mRBC-subst 1-35 exhibited a linear relation with local PO2 changes, RBCs from transgenic mice that had enhanced or weakened deoxyHb-band 3 interactions showed capillary velocity and deformation independent of PO2. RBCs with enhanced deoxyHb-band 3 interactions showed higher capillary velocity and deformability compared to RBCs that had weakened deoxyHb-band 3 ...
A capillary gate mechanism regulates flow resistance efficiently, because pressures, flows, and turbulence are minimal in capillaries, and capillary surface area is greater than that of all larger vessels combined.(1-5) Sympathetic nervous activity releases von Willebrand Factor (VWF) from the capillary endothelium; VWF increases factor VIII activity, which generates insoluble fibrin in the capillary lumen to increase flow resistance (aka viscosity, or systemic vascular resistance). Parasympathetic nervous innervation releases nitric oxide (NO) from the capillary endothelium, which binds to Ca+, inhibits thrombin, accelerates the disintegration of insoluble fibrin, and reduces flow resistance (aka "nitrergic neurogenic vasodilation") Hypoxia and hypercarbia open the capillary gate by releasing nitric oxide from the capillary endothelium.(6) The capillary gate mechanism governs cardiac output, cardiac efficiency, tissue perfusion, tissue oxygenation, and organ function. Its activity affects the ...
discrimination of different flow pattern changes within muscle. Three in vitro models were used: (i) bulk flow rate was varied within a single length of capillary tubing; (ii) at constant bulk flow, capillary volume was increased 3-fold by joining lengths of capillary in series, and compared to a single length; and (iii) at constant bulk flow, capillary volume was increased by sharing flow between a number of lengths of identical capillaries in parallel. The contrast medium for CEU was gas-filled albumin microbubbles. Pulsing interval (time) versus acoustic-intensity curves were constructed and from these, capillary volume and capillary filling rate were calculated. CEU estimates of capillary volume were not affected by changes in bulk flow. Furthermore, as CEU estimates of capillary volume increased, measures of capillary filling rate decreased, regardless of whether capillaries were connected in series or parallel. Therefore, CEU can detect a change in filling rate of the microvascular volume ...
1 Preparation of glass capillary tubes. Glass capillary tubes (Hilgenberg GmbH,D-34321 Malsfeld; article no. 1400290, "Sodaklarglas", length 90 mm, O. D. 1,4 mm, wall 0.261 mm) are rinsed several times in demineralized water, dried, stored in test tubes and autoclaved at 121 C for 20 min, but may be used also without prior washing.. 2 Preparation of capillary holders and plastic straws. For storing the capillaries aluminium tubes or polypropylene tubes are used. They are labelled with the number of the strain preserved by special ink markers (Nalgene Cryo-Marker). If capillaries of more than one strain are to be stored in the same capillary holder, the capillaries are colour coded by putting them into PVC straws cut to length and squeezed together at one end. The accession no. of the strain(s) is written on the straws and the capillary holder. The straws (2 mm in diameter) are available in different colours from A. Albrecht GmbH & Co. KG, D-88323 Aulendorf.. 3 Suspending medium and ...
Your capillaries are the smallest blood vessels in your body that connect arteries to veins. When these capillaries narrow or widen to quickly, the thin capillary walls can tear, and blood can seep out, giving your skin the appearance of thin red or purple lines. While these lines often are not painful, they can be displeasing in appearance, which is why treatments, such as laser treatments are used to remove them.. Broken Capillary Causes. Broken capillaries occur where the skin is the most thin or sensitive, such as the face-especially the cheeks and nose. Events such as hot weather, strong winds, a sunburn, pressure or trauma to the face or other conditions, such as rosacea, can cause broken capillaries. Dry skin also is considered more at risk for broken capillaries.. Lasers and Capillaries. For those who suffer from broken capillaries, lasers are used to deliver targeted treatment to the skin. Laser light energy is concentrated on the targeted vein. Energy is then transferred from the laser ...
Development of a microfluidic chip as artificial blood capillary vessel with integrated impedance sensors for applications in cancer ...
Definition of capillary bed in the Legal Dictionary - by Free online English dictionary and encyclopedia. What is capillary bed? Meaning of capillary bed as a legal term. What does capillary bed mean in law?
Cerebral capillaries represe nt a major i nterface betwee n the ge neral circulatio n a nd the ce ntral nervous system a nd are respo nsible for sufficie nt a nd selective nutrie nt tra nsport to the
Capillaries are the smallest of blood vessels. They serve to distribute oxygenated blood from arteries to the tissues of the body and to feed deoxygenated blood from the tissues back into the veins. The capillaries are thus a central component in the circulatory system, essentially between the arteries and the veins. When pink areas of skin are compressed, this causes blanching because blood is pressed out of the capillaries. The blood is the fluid in the body that contains, among other elements, the red blood cells (erythrocytes) that carry the oxygen and give the blood its red color. See also: * Blood Glossary ...
Capillaries are the smallest blood vessels in the body. These vessels are the sites of exchange between the circulating blood and the body tissues. These vessels are not only very small in diameter, but they have walls that are only a single thin cell in thickness. This is what allows them to be such efficient exchange sites ...
OVENTROP-Temperature controller working without auxiliary energy, with immersion sensor and 5 m capillary. Overheating reliability up to 30 K above the set...
OVENTROP-Temperature controller working without auxiliary energy, with immersion sensor and 5 m capillary. Overheating reliability up to 30 K above the set...
Endothelin-1 (ET-1) is a novel vasoconstricting and cardiotonic peptide that is synthesized by the vascular endothelium. Bovine aortic endothelial cells which secrete ET in vitro lack membrane receptor sites for the peptide. Endothelial cells from rat brain microvessels that do not secrete ET in vitro express large amounts of high-affinity receptors for 125I-labelled ET-1 (Kd 0.8 nM). The ET receptor is recognized by sarafotoxin S6b and the different ET peptides with the following order of potency: ET-1 (Kd 0.5 nM) approximately equal to ET-2 (Kd 0.7 nM) greater than sarafotoxin S6b (Kd 27 nM) greater than ET-3 (Kd 450 nM). This structure-activity relationship is different from those found in vascular smooth muscle cells, renal cells and cardiac cells. ET-1 stimulates DNA synthesis in brain capillary endothelial cells. It is more potent than basic fibroblast growth factor. The action of ET on endothelial cells from microvessels involves phosphatidylinositol hydrolysis and intracellular Ca2+ ...
... The Types of Blood Vessels in Your Body Arteries. Arteries are elastic vessels that transport blood away from the heart. Veins. Veins are elastic vessels that transport blood to the heart. Capillaries. Capillaries are extremely small vessels located within the tissues Sinusoids. Sinusoids are different types of blood vessels in the body There are four different types of blood vessels arteries, veins, capillaries and sinusoids. Arteries carry blood from the heart to the tissues of the body while veins carry What are the three types of blood vessels and their functions? Arteries. Arteries carry blood away from the heart. The largest is the aorta. Veins. Veins are large blood vessels which carry blood back to the heart. Capillaries. Capillaries are the smallest blood vessels. Why not sign up to one different types of blood vessels in the body Chapter Review. Blood pumped by the heart flows through a series of vessels known as arteries, arterioles, capillaries,
Looking for capillary bed? Find out information about capillary bed. The capillaries, collectively, of a given area or organ Explanation of capillary bed
What are broken capillaries?. Well for starters, the term "broken" is actually inaccurate. Broken capillaries are caused when you get a bruise from injury to the skin.. The little red blood vessels that are found in different areas of the face (most commonly the nose, cheeks and chin) are actually permanently dilated capillaries. These are common in lighter, fairer skin types of western European descent (Irish, Scottish). If you have visible capillaries around the corners of the nose (little red, squiggle marks) and nowhere else, these may not be the same - these can be caused simply from blowing your nose from colds and allergies that put pressure on the capillaries.. Where do they come from?. Capillary walls are very elastic, and through repeated dilating from hot showers, spicy foods, microdermabrasion, intense exercise, alcohol, or merely just genetics, they no longer have the ability to contract, remaining visibly enlarged…. Why the difference in colors?. These capillaries form in two ...
The Global Capillary Blood Collection Market 2017-2022 industry, Starting with a broad overview of the Capillary Blood Collection Industry globally as well as with a specific focus on Manufactures. By conducting a check of the current status of the Capillary Blood Collection in Globe 2017-2022 Industry, the report is able to delver deeper into the various forces that directly and indirectly impact the Industry. Global Capillary Blood Collection Industry Segments are based on the analysis of both qualitative and quantitative data. For this, specific data has been gleaned from journals, trade magazines, revenues of leading Industry participants, as well as news reports.. The Research report explores the global Capillary Blood Collection market size and the segment markets by regions, types, applications and companies are also described in depth. Global Capillary Blood Collection Market 2017-2022 Forecast industry statistics, valuable source of guidance and direction for companies and individuals ...
Tumors cells need a rich blood supply in order to grow and metastasize. Angiogenesis (Angio-blood, genesis-creation) is the process by which new blood vessels, called capillaries are formed. Capillaries are lined with endothelial cells. Normal angiogenesis occurs under very tight physiological regulation when stimulators and inhibitors work in balance with each other. Normally the proliferation…
Red blood cells in a capillary (human central nervous system), coloured transmission electron micrograph (TEM). Red blood cells (RBCs), or erythrocytes, are the most common type of blood cell in vertebrates. They are involved in delivering oxygen to the body tissue. RBCs take up oxygen in the lungs or gills and release it into tissues while squeezing through the bodys capillaries. The cytoplasm of RBCs is rich in haemoglobin, an iron-containing biomolecule that can bind oxygen and is responsible for the red color of the cells. The cell membrane is composed of proteins and lipids and this structure provides properties essential for physiological cell function (deformability and stability) while traversing the circulatory system, especially the capillary network. In humans, mature RBCs are flexible and oval biconcave disks. Capillaries are the small blood vessels that make up the microcirculation of the human body. Magnification: x2,130 when shortest - Stock Image C032/0833
Specimen: Capillary Blood. Container(s): Capillary Blood Gas Tube. Preferred Vol: 2 Capillary Blood Gas Tubes. (EPOC capillary tubes are not acceptable). Minimum Vol: 2 Capillary Blood Gas Tubes. Note: Draw site must be warmed for 10 minutes. Fill the tube completely with no air bubbles and mix thoroughly to dissolve and disperse the heparin. Cap it securely. Deliver to the Lab on ice.. ...
As blood enters capillaries from arterioles (small arteries), it slows down. This allows substances in the plasma, as well as O2 from red blood cells, to diffuse through the capillary wall into the surrounding tissues (the capillary wall is thin and permeable ...
The walls of capillaries are composed of a single layer of microvascular endothelial cells. These cells differ in morphology and other properties depending on the tissues the capillaries supply. Therefore,Creative Bioarray offers a range of Microvascular Endothelial Cells produced at Creative Bioarrays cell culture facility from normal human tissues of different origins ...
These lines are to imitate the blood capillary network structure, which main function is to exchange the fluids and provide nutritional substances despite the gravity. Structures of this type occur in plants as well as animals and human organisms. Capillaries are also used in modern technologies ...
Capillaries are composed of a microscopic tubule made from a continuous layer of endothelial cells surrounded by a layer of connective tissue for support. In arteries, the contractile outer layer is formed by vascular smooth muscle cells. These smooth muscle cells contribute to regulating blood pressure in the capillaries. Capillaries also contain a ring-like sphincter of smooth muscle at their opening which regulates blood flow into the capillaries.. Capillary beds are optimized for blood/tissue exchange of nutrients, gases (such as oxygen) and migrating immune cells. The smaller diameter of capillaries and the slower blood flow through them means that nearly all of the blood comes into contact with the walls of the tubule. Capillary endothelial cells thus have greater access to circulating cytokines than the endothelial cells of the larger arteries and veins. During inflammation, elevated levels of IL-6, like TNF, induce vascular relaxation, leakiness of plasma fluids, and increased migration ...
An easily-assembled, heat-resistant connector for releasably joining end portions of two capillary tubes in end-to-end fashion for use in chromatography without interrupting fluid flow or interfering with chromatographic results, comprises a cylindrical sleeve which has a bore which tapers toward a center point to form press-fit seals with the tips of two capillary tubes. A first ferrule is mounted on the end portion of a first capillary tube, and a second ferrule is mounted on the end portion of a second capillary tube. A jacket surrounds and contains the sleeve, and a first adjustment screw mounted on the jacket pushes against the first ferrule to deform the ferrule into sealing contact with the outside surface of the first capillary tube and with the inside surface of the sleeve. A second adjustment screw mounted on the jacket pushes against the second ferrule to deform the ferrule into sealing contact with the outside surface of the second capillary tube and with the inside surface of the
Unscramble capillary, Unscramble letters capillary, Point value for capillary, Word Decoder for capillary, Word generator using the letters capillary, Word Solver capillary, Possible Scrabble words with capillary, Anagram of capillary
In Human Anatomy and Physiology What do capillaries do? Capillaries are small blood vessels connecting the little arteries (arterioles) into the compact veins (venules). The blood vessels have oxygen and nutrients to each of the individ…ual cells in the body. The human capillary procedure is built up of arteries with their terminal branches (arterioles) and veins additionally their tributaries (venules ...
Capillaries are small blood vessels that transport nutrients throughout our bodies and help carry out waste. The strength of the capillary walls is an...
Blood Capillaries for coagulation, 90 mm,Price: RM55.65,End time 10/13/2018 6:08 PM MYT,Category: Laboratory Equipment / B2B & Industrial Products
Exchange of substances between blood capillaries and the interstitial fluid of tissues is regulated by hydrostatic pressure and osmotic pressure. Fluid leaves the blood capillaries at the arteriolar end of a capillaries. About 90% of this fluid reenters capillaries at their venular ends. The remaining fluid is returned to the blood through lymphatic system ...
Author: Dirnagl, U. et al.; Genre: Journal Article; Published in Print: 1990; Title: In vivo confocal laser scanning microscopy (CLSM): laser light induced alterations of erythrocyte flow in rat brain capillaries sensitized with intravascular fluorescein
Results Our results show that Ang II (1 nmol/L) induced the expression of VEGF and enhanced capillary formation from endothelial cells in the Matrigel assay. This effect was significantly depressed by the AT1R blocker losartan and different inhibitors (irestatin, IRE1 specific inhibitor; SP600125, JNK specific inhibitor; SB203580, p38 MAPK specific inhibitor) but not by the AT2R blocker PD123319. Next, we investigated the effect of Ang II on the IRE1/JNK/p38 MAPK pathway and the 78 kilodalton glucose regulated protein 78 (GRP78) activity in HUVECs and the role of the AT1 Receptor. The results show that Ang II activated both the IRE1/JNK/p38 MAPK pathway and GRP78 binding activity. These effects were markedly inhibited by the AT1R blocker losartan. The IRE1 specific inhibitor irestatin, the JNK specific inhibitor SP600125, and the p38 MAPK specific inhibitor SB203580 significantly inhibited Ang II-induced capillary formation from endothelial cells and VEGF expression but had no effect on ...
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The retina is a privileged location where we can look at the fine capillary blood vessels and directly observe damage so we will describe capillary changes as they are seen to develop in the retina.. Stage One. The earliest changes in retinopathy involve decreased function of nerve cells in the retina, before any visible vascular changes occur.. Stage Two. High blood sugar damages capillary vessel walls causing them to become leaky and develop bulges, called microaneurisms. Leakage first consists of the clear serum part of blood, then red blood cells. Leakage into any tissues is called edema. Edema in the center of the retina is called Macular Edema and will impair vision.. Stage Three. The capillaries shut down and stop delivering blood. The expected outcome of this is that the retina, deprived of its blood supply, doesnt function well and eventually dies. The unexpected part is that the hypoxic retina sends out a chemical help messenger that stimulates growth of new vessels, which sounds like ...
TY - JOUR. T1 - Localization of organic anion transporting polypeptide 3 (oatp3) in mouse brain parenchymal and capillary endothelial cells. AU - Ohtsuki, Sumio. AU - Takizawa, Takuya. AU - Takanaga, Hitomi. AU - Hori, Satoko. AU - Hosoya, Ken Ichi. AU - Terasaki, Tetsuya. PY - 2004/8/1. Y1 - 2004/8/1. N2 - Organic anion transporting polypeptide 3 (oatp3) transports various CNS-acting endogenous compounds, including thyroid hormones and prostaglandin E2, between extra- and intracellular spaces, suggesting a possible role in CNS function. The purpose of this study was to clarify the expression and localization of oatp3 in the mouse brain. RT-PCR analysis revealed that oatp3 mRNA is expressed in brain capillary-rich fraction, conditionally immortalized brain capillary endothelial cells, choroid plexus, brain and lung, but not in liver or kidney, where oatp1, 2 and 5 mRNAs were detected. Immunohistochemical analysis with anti-oatp3 antibody suggests that oatp3 protein is localized at the ...
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When a problem occurs on the coating line and a circuit board is defective there is generally a good reason for the occurence. This week Nexus takes a look at Capillary Flow. Capillary flow (or scavenging) in conformal coating processing is where the coating pulls or runs away from certain areas of a PCB to…
This software allows the user to calculate the measurements of a capillary tube throttling device for a refrigeration system using empirical formulas. The result is a start value for optimization. The start value will result in an acceptable operating system. In certain cases, the best possible choice of capillary diameter and length might deviate remarkably from this calculated result.. The capillary sizing is based on the assumption, that the capillary and suction line is connected to in min. 1 m to make internal heat exchange between liquid and suction gas.. ...
Front Neuroanat. 2012 Sep 13;6:38. eCollection 2012. Marín-Padilla M1. Abstract The capillary from the meningeal inner pial lamella play a crucial role in the development and structural organization of the cerebral cortex extrinsic and intrinsic microvascular compartments. Only pial capillaries are capable of perforating through the cortex external glial limiting membrane (EGLM) to enter into the nervous tissue, although incapable of perforating the membrane to exit the brain. Circulatory dynamics and functional demands determine which capillaries become arterial and which capillaries become venous. The perforation of the cortex EGLM by pial capillaries is a complex process characterized by three fundamental stages: (1) pial capillary contact with the EGLM with fusion of vascular and glial basal laminae at the contact site, (2) endothelial cell filopodium penetration through the fussed laminae with the formation of a funnel between them that accompanies it into the nervous tissue while ...
Front Neuroanat. 2012 Sep 13;6:38. eCollection 2012. Marín-Padilla M1. Abstract The capillary from the meningeal inner pial lamella play a crucial role in the development and structural organization of the cerebral cortex extrinsic and intrinsic microvascular compartments. Only pial capillaries are capable of perforating through the cortex external glial limiting membrane (EGLM) to enter into the nervous tissue, although incapable of perforating the membrane to exit the brain. Circulatory dynamics and functional demands determine which capillaries become arterial and which capillaries become venous. The perforation of the cortex EGLM by pial capillaries is a complex process characterized by three fundamental stages: (1) pial capillary contact with the EGLM with fusion of vascular and glial basal laminae at the contact site, (2) endothelial cell filopodium penetration through the fussed laminae with the formation of a funnel between them that accompanies it into the nervous tissue while ...
Facts about Capillaries present the information about the smallest features on the blood vessels of the body. The capillaries are very important for the body
I. Capillaries are the site of exchange of nutrients and waste products between blood and tissues. II. Blood flows through the capillaries more slowly than
It is very likely that, like in veins, genetic factor is the most dominant - there is a weakening of valve mechanism in capillaries of fat tissue, with inherently weak muscle fascia.. Likewise, usually a disorder of posture (flat feet) is present, being overweight, lack of activity, hormones, pregnancy, age.. Usually causes are combined. In contemporary times, they are provoked by bathing in hot water, frequent sauna visits, floor heating, intensive anticellulite massages.. They can occur at any age, location on the body is not strictly determined, they occur in both sexes - men have them more often on their face and nose, and women on their legs.. Unfortunately, once they appear, they have a continuous tendency of spreading and enlargement. Therefore, treatments should be started in time and maintained regularly - varicose and cracked capillaries are difficult, almost impossible to remove completely. But, it is possible, with regular treatments, to keep them under control.. ...
The TFV fire safety valve was designed to address the growing requirement of oil fired heating protection. Manufactured to adhere to building regulations (BS5410 Part 1) and certified to OFTEC standard OFS E101. This valve has not only proven sensitive enough to cope with the minimal flows experienced within a domestic application, but it is also capable of the high flow rates demanded for industrial installations. Available in sizes 1/4 to 1/2 and capillary lengths up to 6m.
An apparatus for transporting blood samples within a capillary tube using a rigid plate member to protect the capillary tube during transport. A magnet is magnetically coupled with and thereby moves a ferrous metal flea within the capillary tube to promote mixing of the blood sample and an anticoagulant chemical coating on the inside of the capillary tube. The magnet is slid along the length of a recessed guide track or guide members to assure that the magnet does not come in contact with the capillary tube with sufficient force to break the capillary tube. The magnet has a central archway through which the capillary tube extends to increase the magnetic coupling between the magnet and the flea and yet prevent contact with the capillary tube. The capillary tube is held within an alignment groove in the rigid plate member. In one embodiment, a holder holds the capillary tube against the rigid plate. A recess is provided to receive one end of the capillary tube and a slot is provided to receive the other
Rete ridges (wrinkles) are epidermal thickenings that extend downward between dermal papillae. These are or interest to nurses where they can be mapped as "Langers lines" indicating the direction in which they usually lie. "Crows feet" at the outer edge of the eyes is an example of skin wrinkles which typically allow movement in one direction. Incisions along these lines will leave the least obvious scar, while incisions across these lines will cause dog-eared puckering of the healed skin.. Blood capillaries are found beneath the epidermis, and are linked to an arteriole and a venule.. ...
17th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2013), Freiburg, October 27-31, 2013 Proceedings on USB-Stick Chemical and Biological Microsystems Society (CBMS), ...
A sheath flow type flow-cell device for plow-cytometer which comprises a first inlet for sheath fluid, a flow passage communicated with the first inlet and contracted toward downstream, the flow passage having a substantially rectangular cross section, a straight capillary flow passage connected to the flow passage downstream thereof, the capillary flow passage having a substantially rectangular cross section, a second inlet for sample fluid, a nozzle communicating with the second inlet and opened within the flow passage in the same direction as the flow direction of the straight capillary flow passage, a discharge port provided at a terminal end of the straight capillary flow passage, and flow regulating means for regulating the flow of the sheath fluid in the straight capillary flow passage to be a laminar flow having a gradient of flow velocity.
Longest region of the nephron. Made of a single layer of epithelial cells adapted for selective reabsorption of solutes: they possess microvilli to provide larger surface area for reabsorption by carrier proteins, and have many mitochondria for ATP for active transport of solutes.. Renal capillaries are close to the tubule, so short diffusion pathway for reabsorption. All of the glucose and amino acids are reabsorbed, and about 85% of the sodium ions by active transport. About half of the urea passes back into the blood by facilitated diffusion. All of this reabsorption, along with the presence of plasma proteins in the capillaries, lowers the water potential of the blood in the capillaries of that about 85% of the water in the filtrate is reabsorbed by osmosis.. The plasma membrane near to the capillaries is highly folded to form lots of intercellular spaces. When solutes, e.g. Na+ are actively transported out of the epithelial cells into the intercellular spaces, it increases the ion ...
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Adamant Ceramic Capillaries are manufactured by our Injection Molding Technology. It achieves excellent concentricity property. This quality reduces the hours of operation significantly at the time of replacement due to the elimination of alignment. ...
the standard 90 and 120 double inside chamfer capillaries are also available with an optional radiused inside chamfer at a moderate additional cost.. ...
If bruises appear, then the capillaries are very thin. When you hit something and then a bruise appears, thats fine. … Continue reading "Why Do Bruises Appear Randomly For No Reason". ...
Blood Vessels. System of blood vessels includes arteries, veins and capillaries. The arteries transport blood away from the heart and veins bring blood toward the heart. Blood moves from the right side of the heart to the lungs through pulmonary arteries and returns to the left side of the heart through the pulmonary veins. The left side of the heart pumps blood into an artery aorta this leads other arteries like highways. Capillaries are the smallest of the blood vessels are at the end of the supply line they receive and distribute the goods. Capillary walls are so thin that molecules of oxygen and nutrients pass right through into the cells and molecules of carbon dioxide and other waste products pass from the cells into the blood. Then when is through with the delivery and taking on a new load of waste products blood flows into tiny veins in turn lead to larger veins on the return trip to the heart.. Blood. The blood consists of a liquid called plasma, solid material, red cells, white cells, ...
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Lymph is a fluid which bathes all the cells of the body. It is also called ICF (Intercellular fluid). This is made up of mostly fluid that escapes from the blood through the walls of the capillaries. Tiny, lymphatic capillaries are found in all tissues of the body. These join to form lymph vessels which are thin walled vessels that also contain valves to prevent backflow. Eventually, all lymph returns to the circulatory system through various ducts that empty into large veins below the neck. In this way, fluid that is lost through the capillary is returned to the blood. At intervals along the lymph vessels, there are bead-like enlargements called lymph nodes. Here, phagocytic white blood cell, some of which are produced in the lymph nodes, remove bacteria and other foreign particles (antigens) from the lymph (ICF). When a lymph nodes enlarges (becomes swollen), it can be an indication of some type of infection.. ...
The force of the pump that pushes blood through the arteries is dissipated as the blood flows through capillaries. Although capillaries are tiny, the total cross-sectional area of all the capillaries supplied by a single artery is much greater than that of the artery itself. Like a rapid, narrowly-confined stream spreading out over a flat plain, the force and velocity of flow diminish quickly. This creates a problem: ...
The Cardiovascular System consists of the heart, blood, and blood vessels. The heart is the hardest working muscle in the body as it beats non-stop 60 to 100 beats per minute pumping blood throughout the blood vessels by repeated, rhythmic contractions. In addition, the heart is located in the mediastinum, which is in the middle of the thoracic cavity and behind the sternum. In the majority of the population, the apex points towards the left.. Moreover, the pericardium encloses the heart for protection. The pericardium contains serous fluid which serves as a lubricant to reduce friction from muscle movement. A network of blood vessels carries oxygen and nutrients to all the tissues of the body. Arteries are the blood vessels that take blood away from the heart. Whereas, veins are the blood vessels that return blood to the heart. Capillaries are very small blood vessels that lie between the arteries and veins.. This seems like too much information to just throw in a paragraph. To facilitate all ...
Blood vessels. Artwork of an artery (top), capillary (middle) and vein (bottom). From inside to out, arteries and veins are made of: a thin layer (intima) of endothelial cells, a thick layer (media) of smooth muscle, elastic fibres and connective tissue that support the vessels structure, and an outer protective layer (adventitia) of connective tissue and nerves. Arteries mainly carry oxygenated blood from the heart at high pressures, so they have thicker, stronger and more elastic walls. Capillaries are the thinnest type of vessel. They are composed of one layer of epithelial cells, allowing nutrients and waste products to be exchanged through them. Veins have much thinner and less elastic walls than arteries as they do not need to withstand high pressures. They rely on gravity and skeletal muscle contractions to transport blood back to the heart. Some contain one-way valves to prevent blood flowing in the wrong direction. - Stock Image C021/2549
BLOOD VESSELS. A system of blood vessels carries the blood through the body. These vessels include arteries, veins and capillaries. Some of your arteries and veins are as big around as your thumb; others are almost too small to see. Arteries have thick walls and a smaller inside diameter than do veins. The walls of arteries are muscular and elastic, allowing them to expand and contract easily. The walls of veins are thin and contain less muscle tissue than arteries. The walls of capillaries are only one cell layer thick, and cannot be seen without a microscope. These three types of vessels and the heart make up the circulatory system.. Your blood vessels are a seemingly endless stream of hollow, soft, elastic tubes. It is estimated that if an adults vessels were laid end-to-end, they would stretch over 12,400 miles. That is more than four times the distance across the United States.. The blood vessel system carries blood from the heart to all parts of the body. Blood leaves the left side of the ...
Press Release issued Sep 15, 2017: Market Research Report on Capillary Underfill Material Market 2017 is a professional and in-depth study on the current state of the Capillary Underfill Material worldwide. First of all, Global Capillary Underfill Material Market 2017 report provides a basic overview of the Capillary Underfill Material industry including definitions, classifications, applications and Capillary Underfill Material industry chain structure.
Residual gas saturation is one of the most important parameter in determining recovery factor of water-drive gas reservoir. Visual observation of processes occurring at the pore level in micromodels can give an insight to fluid displacements at the larger scale and also help the interpretation of production performance at reservoir scale. In this study experimental tests in a glass micromodel were used to determine the influence of the capillary number and pore morphology on the residual gas saturation in gas-liquid two-phase flow. The saturation of the phases was determined through recorded images in the micromodel. 2D modeling and simulation of this process is presented in this study and simulation results are verified by comparing to experimental results where sufficient agreement was confirmed. The simulation results indicate that pore morphology and capillary number have significant influence on the competition between frontal displacement and snap-off. Frontal displacement leads to high recovery
You take great care assessing and considering risks when dealing with your financial portfolio, including property purchases. The same cant be said for purchasing vehicles since these decisions are purely driven by emotion. Why then would you risk the state of your health, your most precious and important asset?. If you have been taking chronic medication for some time then you are aware that your condition is progressing, meaning that your health status is slowly declining. This is simply because the underlying causes have not been addressed.. The most common chronic health condition in South Africa (and the world) is hypertension or high blood pressure. This is a sign that capillaries are not being adequately perfused, meaning that blood is not moving into the capillaries to service your cells and is basically waiting in your arterioles or venules. Hypertension is a common precursor to other chronic diseases and, as you know, is extremely dangerous.. By now you fully aware that, after ...
The formation of urine begins in the same manner as the formation of tissue fluid by filtration of plasma through capillary pores. These capillaries are known
For everyone worried I am doing good and I am doing as expected. Basically my body is in shock from the surgeries so my capillaries are freaking out! Have you ever sprained your ankle and swollen up really bad? Basically whenever there is trauma to the capillaries the vanes start "leaking". I am simply "third spacing" which means I am loosing extracellular fluid from the vascular vanes to other body compartments making me extremely swollen. The down side to this is because I loose these fluids my blood pressure drops which apparently freaks them out ...
The network of capillaries in a particular area or organ of the body. Exchanges that occur in capillary beds include; transfer of oxygon and nutrients to cells, removal of carbon dioxide and wastes from cells, and the transfer of fluids with cells (which enables white blood cells to enter the interstitial tissues). The capillary bed usually carries no more than 25% of the amount of blood it could contain, although this amount can be increased through autoregulation by inducing relaxation of smooth muscle. The capillaries do not possess this smooth muscle in their own walls, and so any change in their diameter is passive. Any signalling molecules they release (such as endothelin for constriction and nitric oxide for dilation) act on the smooth muscle cells in the walls of nearby, larger vessels, e.g. arterioles. See also: * Blood Glossary ...
The network of capillaries in a particular area or organ of the body. Exchanges that occur in capillary beds include; transfer of oxygon and nutrients to cells, removal of carbon dioxide and wastes from cells, and the transfer of fluids with cells (which enables white blood cells to enter the interstitial tissues). The capillary bed usually carries no more than 25% of the amount of blood it could contain, although this amount can be increased through autoregulation by inducing relaxation of smooth muscle. The capillaries do not possess this smooth muscle in their own walls, and so any change in their diameter is passive. Any signalling molecules they release (such as endothelin for constriction and nitric oxide for dilation) act on the smooth muscle cells in the walls of nearby, larger vessels, e.g. arterioles. See also: * Blood Glossary ...
The network of capillaries in a particular area or organ of the body. Exchanges that occur in capillary beds include; transfer of oxygon and nutrients to cells, removal of carbon dioxide and wastes from cells, and the transfer of fluids with cells (which enables white blood cells to enter the interstitial tissues). The capillary bed usually carries no more than 25% of the amount of blood it could contain, although this amount can be increased through autoregulation by inducing relaxation of smooth muscle. The capillaries do not possess this smooth muscle in their own walls, and so any change in their diameter is passive. Any signalling molecules they release (such as endothelin for constriction and nitric oxide for dilation) act on the smooth muscle cells in the walls of nearby, larger vessels, e.g. arterioles. See also: * Blood Glossary ...
The network of capillaries in a particular area or organ of the body. Exchanges that occur in capillary beds include; transfer of oxygon and nutrients to cells, removal of carbon dioxide and wastes from cells, and the transfer of fluids with cells (which enables white blood cells to enter the interstitial tissues). The capillary bed usually carries no more than 25% of the amount of blood it could contain, although this amount can be increased through autoregulation by inducing relaxation of smooth muscle. The capillaries do not possess this smooth muscle in their own walls, and so any change in their diameter is passive. Any signalling molecules they release (such as endothelin for constriction and nitric oxide for dilation) act on the smooth muscle cells in the walls of nearby, larger vessels, e.g. arterioles. See also: * Blood Glossary ...
Statistically broken capillaries on legs and varicose veins usually affect women as opposed to men and can be a real problem for some people. Before you get set to deal
Oxidative Medicine and Cellular Longevity is a unique peer-reviewed, Open Access journal that publishes original research and review articles dealing with the cellular and molecular mechanisms of oxidative stress in the nervous system and related organ systems in relation to aging, immune function, vascular biology, metabolism, cellular survival and cellular longevity. Oxidative stress impacts almost all acute and chronic progressive disorders and on a cellular basis is intimately linked to aging, cardiovascular disease, cancer, immune function, metabolism and neurodegeneration. The journal fills a significant void in todays scientific literature and serves as an international forum for the scientific community worldwide to translate pioneering
Blood vessels (arteries, veins and capillaries) are not something you would normally associate with fossils, but newly puublished...
Background Many abnormalities are known to occur in the microcirculation in essential hypertension, including reduction in capillary density or rarefaction. Peripheral vasodilatation and angiogenesis are critical components of the physiological adaptation in normal pregnancy.Objective To investigate
These New Open-End Quartz Capillary Tubes have a Funnel on one end and are open on the other end or bottom of the capillary tubes. ...
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Before insulin can stimulate myocytes to take up glucose, it must first move from the circulation to the interstitial space. The continuous endothelium of skeletal muscle (SkM) capillaries restricts insulins access to myocytes. The mechanism by which insulin crosses this continuous endothelium is critical to understand insulin action and insulin resistance; however, methodological obstacles have limited understanding of endothelial insulin transport in vivo. Here, we present an intravital microscopy technique to measure the rate of insulin efflux across the endothelium of SkM capillaries. This method involves development of a fully bioactive, fluorescent insulin probe, a gastrocnemius preparation for intravital microscopy, an automated vascular segmentation algorithm, and the use of mathematical models to estimate endothelial transport parameters. We combined direct visualization of insulin efflux from SkM capillaries with modeling of insulin efflux kinetics to identify fluid-phase transport as ...
Before insulin can stimulate myocytes to take up glucose, it must first move from the circulation to the interstitial space. The continuous endothelium of skeletal muscle (SkM) capillaries restricts insulins access to myocytes. The mechanism by which insulin crosses this continuous endothelium is critical to understand insulin action and insulin resistance; however, methodological obstacles have limited understanding of endothelial insulin transport in vivo. Here, we present an intravital microscopy technique to measure the rate of insulin efflux across the endothelium of SkM capillaries. This method involves development of a fully bioactive, fluorescent insulin probe, a gastrocnemius preparation for intravital microscopy, an automated vascular segmentation algorithm, and the use of mathematical models to estimate endothelial transport parameters. We combined direct visualization of insulin efflux from SkM capillaries with modeling of insulin efflux kinetics to identify fluid-phase transport as ...
Before insulin can stimulate myocytes to take up glucose, it must first move from the circulation to the interstitial space. The continuous endothelium of skeletal muscle (SkM) capillaries restricts insulins access to myocytes. The mechanism by which insulin crosses this continuous endothelium is critical to understand insulin action and insulin resistance; however, methodological obstacles have limited understanding of endothelial insulin transport in vivo. Here, we present an intravital microscopy technique to measure the rate of insulin efflux across the endothelium of SkM capillaries. This method involves development of a fully bioactive, fluorescent insulin probe, a gastrocnemius preparation for intravital microscopy, an automated vascular segmentation algorithm, and the use of mathematical models to estimate endothelial transport parameters. We combined direct visualization of insulin efflux from SkM capillaries with modeling of insulin efflux kinetics to identify fluid-phase transport as ...
Before insulin can stimulate myocytes to take up glucose, it must first move from the circulation to the interstitial space. The continuous endothelium of skeletal muscle (SkM) capillaries restricts insulins access to myocytes. The mechanism by which insulin crosses this continuous endothelium is critical to understand insulin action and insulin resistance; however, methodological obstacles have limited understanding of endothelial insulin transport in vivo. Here, we present an intravital microscopy technique to measure the rate of insulin efflux across the endothelium of SkM capillaries. This method involves development of a fully bioactive, fluorescent insulin probe, a gastrocnemius preparation for intravital microscopy, an automated vascular segmentation algorithm, and the use of mathematical models to estimate endothelial transport parameters. We combined direct visualization of insulin efflux from SkM capillaries with modeling of insulin efflux kinetics to identify fluid-phase transport as ...
As a new capillary grows from a blood vessel, a series of cellular processes occur. These vascularization events have been extensively studied experimentally, however the whole angiogenic sequence has yet to be characterized by any experiment or model, and numerous unknowns remain. What is known is that an endothelial cell from an existing vessel becomes activated. The activated cell starts to migrate into the extracellular matrix by degrading it; this unique, spindle-shaped cell is called the tip cell. Cells adjacent to the tip cell begin to proliferate, and follow the tip cell; they are referred to as stalk cells. These processes result in formation of a sprout [1]. This capillary sprout moves towards a stimulus, in response to chemical cues, mechanical factors, and a degree of random motility. Finally, the sprout joins an adjacent capillary. Together these events define the process of sprouting angiogenesis.. Hypoxia is a main stimulus for angiogenesis during ischemia, exercise, inflammation, ...
The paper presents the results of various SABCA activities in the field of two-phase heat transport, being a critical review and analysis of existing capillary pumped loops, the identification of the needs of future capillary pumped two-phase thermal control systems, the development of capillary evaporators, which incorporates nickel porous structures, that can provide a pumping pressure up to 38000 Pa, and the solving of the problem of capillary pump cavitation.These activities have led towards the development of a reliable multi-evaporator/condenser capillary pumped loop, which is discussed in details.A test loop configuration is described. The presented results of various tests clearly prove the viability of the concept for future applications.Proposed flight demonstrations are presented ...
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Capillary desaturation ◊ capillary number ◊ fracture 2D network ◊ fracture aperture map ◊ imbibition ◊ Natural fractures ...
Guarda Foto stock di Crosssection Of An Alveolar Capillary Showing A Red Blood Cell Or Erythrocyte Tem X30000. Cerca foto premium ad alta risoluzione su Getty Images.
The present study focuses on the quantitative changes of the capillary bed in aging human skin. Forty-five skin samples were excised from the anterior thoracic region of cadavers of caucasian origin in the age range 33-82 years. The immunohistochemic
Angiogenesis is defined as the formation of new capillary blood vessels from pre-existing ones. This process involves several steps including: migration, proliferation and differentiation of endothelial cells into blood vessels. Angiogenesis is initiated by binding of specific growth factors, such as vascular endothelial growth factor (VEGF) and fibroblast growth factor (FGF), to their cell surface receptors. Shb is a ubiquitously expressed adaptor protein with the ability to bind several tyrosine kinase receptors. My aim has been to identify the role of Shb in FGF- and VEGF-signalling in endothelial cells. Shb was found to be phosphorylated in a Src-dependent manner upon both FGF- and VEGF-stimulation. This was confirmed using fibroblasts overexpressing temperature sensitive v-Src. Furthermore, Shb-induced cell spreading on collagen of immortalised brain endothelial (IBE) cells was also Src-dependent. FGF stimulation led to a direct association between Shb and FAK, which was mediated by the ...
Main Benefits of EzyDetox. 1. Generate heating effects:cause molecules to react. 2. Break down water molecules:increase absorption and distribution by 2 times. 3. Become a single H2O:effective for metabolism and moisturiszing. 4. Easily penetrate into cell membranes. 5. Activate cells. 6. Expand and unlock lympahticglands. 7. Boost immunity to prevent cancer. 8. Expand blood capillaries. 9. Improve blood circuatlion:total length of blood capillaries 100,000 km. 10. Promote metabolism:effective digestion and energy production. 11. Anti bacteria and viral infection. ...
For demonstrating that capillary rise is dependent upon the inner diameter of a tube. Proves that the molecules of a liquid are more attracted to glass than to other liquid molecules.. Consists of four glass capillary tubes of different inner diameters with a large tube serving as reservoir. Mounted on a stand. Height of the tubes is about 15cm.. ...
Brain capillary endothelial cells join tightly together to form the BBB, which separates the brain from the blood and prevents exposure of the CNS to circulating toxins and harmful chemicals. A number of transporters are expressed on the BBB, which prevent therapeutic drugs and toxins from entering the brain, or actively bring nutrients or neurotransmitters into the brain.
Capillary - Relating to or resembling a hair; fine and slender. Having a very small internal diameter: a capillary tube. Anatomy. Of or relating to the capillaries. Physics. Of or relating to capillarity. n., pl. -ies. Anatomy. One of the minute blood vessels that connect arterioles and venules. These blood vessels form an intricate network throughout the body for the interchange of various substances, such as oxygen and carbon dioxide, between blood and tissue cells. A tube with a very small internal diameter. Membrane - A flexible layer surrounding a cell, organelle (such as the nucleus), or other bodily structure. The movement of molecules across a membrane is strictly regulated in both directions. ...
This paper describes laboratory equipment and procedures aimed at determining drainage gas-oil capillary pressure functions under reservoir conditions. Two series of capillary drainage tests (porous plate method) were performed with sandstone core samples using binary mixtures of methane/n-heptane at different equilibrium pressures, leading to very wide variations in the gas-liquid interfacial tension (IFT) values. Measurements were performed first without connate water (two-phase conditions) and then in the presence of connate water saturation (three-phase conditions). This study has shown that the gas-oil capillary pressures measured at different levels of IFT and without connate water can be transformed into one capillary pressure function, Pc/IFT, down to IFT = 3.7 mN/m. Below this value, the capillary pressures measured were significantly lower than those estimated by the Young-Laplace equation. In the presence of connate water, the gas-oil capillary pressures were always higher than the ...
All it takes is the flip of a protein switch within the tiny wire-like capillaries of the brain to increase the blood flow that ensures optimal brain fun ...
We study the breakup of confined fluid threads at low flow rates to understand instability mechanisms. To determine the critical conditions between the earlier quasi-stable necking stage and the later unstable collapse stage, simulations and experiments are designed to operate at an extremely low flow rate. The critical mean radii at the neck centres are identified by the stop-flow method for elementary microfluidic configurations. Two distinct origins of capillary instabilities are revealed for different confinement situations. One is the gradient of capillary pressure induced by the confinements of geometry and external flow, whereas the other is the competition between the capillary pressure and internal pressure determined by the confinements ...
TY - JOUR. T1 - Penetration of small molecular weight substances through cultured bovine brain capillary endothelial cell monolayers. T2 - the early effects of cyclic adenosine 3,5‐monophosphate. AU - Deli, MA. AU - Dehouck, MP. AU - Abraham, CS. AU - Cecchelli, R.. AU - Joo, F.. PY - 1995/7/1. Y1 - 1995/7/1. N2 - Second messengers, such as cyclic adenosine 3,5‐monophosphate (cAMP), have been shown to take part in the regulation of blood‐brain barrier permeability. in the present study, elevation of cAMP levels decreased sucrose (mol. wt, 342) and inulin (mol. wt, 5000) permeability across monolayers of bovine brain capillary endothelial cells as early as 1 h after exposure. Since both tracers use predominantly a paracellular pathway, we assume that cAMP may increase the tightness of the tight junctions through protein phosphorylation.. AB - Second messengers, such as cyclic adenosine 3,5‐monophosphate (cAMP), have been shown to take part in the regulation of blood‐brain barrier ...
PURPOSE: To characterize the properties of the glucose transporters of bovine retinal capillary endothelial cells and pericytes and to determine the effects of increased glucose concentrations on glucose transport activity. METHODS: Primary cultures of bovine retinal capillary endothelial cells and pericytes were exposed to low and high glucose concentrations, and immunoblot analysis, 14C-3-O-methylglucose transport activity, and cytochalasin B binding assays were used to characterize the glucose transporters. RESULTS: GLUT1, but not GLUT3 or GLUT4 transporter isoforms, was present in plasma membranes isolated from each cell type. The EC50 for glucose transport was similar in endothelial cells and pericytes (3.94 to 0.48 mM versus 2.24 to 0.69 mM) and was consistent with the EC50 previously reported for GLUT1 transporters on other cells, as was the observation that insulin did not acutely stimulate glucose transport in either cell type. The Vmax for glucose transport was greater in pericytes ...
Background: A small number of studies used nailfold capillaroscopy (NC) in the evaluation of nailfold capillary changes in Behçets disease (BD). The purpose of this study was to investigate the characteristics and frequency of nailfold capillary changes in BD by dermatoscopy and videodermatoscopy and to develop a scoring system for those capillary changes to predict the activity and severity of the disease. Methods: We performed NC on 40 BD patients and 20 healthy controls with dermatoscopy and videodermatoscopy. Capillary morphology, distribution, and density were analyzed qualitatively and quantitatively. We also assessed the activity and severity of the disease with BD Current Activity Form and BD Severity Score Classification and evaluated the relation of these scores with morphology scores and capillary density. Results: Capillary morphologic alterations were encountered significantly more in BD group (P , 0.05). Loss of continuity in capillary loops and irregularity of capillary ...
Editor,-Studies on visual field and peripheral circulation had led to the hypothesis that the eye might be involved in the vasospastic syndrome,1 a potential contributor to glaucomatous optic neuropathy.2 In some patients with peripheral vasospasms, visual field defects worsened after cold provocation, and, often, both peripheral vasospasms and visual field defects improved after calcium channel blocker treatment.1Because these and newer observations3 suggest some parallels in ocular and digital blood flow regulation, the relation between ophthalmic artery and nailfold capillary blood flow velocities was evaluated.. Fifty patients with primary open angle glaucoma with a mean age of 67 (SD 15) years were examined. Excluded were patients with previous filtering surgery or systemic and cardiovascular diseases. Blood flow velocity in nailfold capillaries was assessed in one randomly chosen finger of the right hand (totally arbitrary choice) by means of nailfold capillaroscopy.4 The velocities ...
The bronchial circulation undergoes angiogenesis in several pathological conditions, such as lung neoplasm and bronchiectasis, but whether the pulmonary circulation can do this has been questioned. A woman treated with mitomycin C and 5-fluorouracil developed progressive, fatal pulmonary hypertension over 5 months. In addition to light and transmission electron microscopic examination of her lung, her pulmonary vasculature was cast and the casts were studied with scanning electron microscopy. Light microscopy showed that she had pulmonary veno-occlusive disease and angiomatoid capillary growth in the alveolar walls. Transmission electron microscopy confirmed the presence of pulmonary hypertension and showed thickened endothelial basement membrane. Scanning electron microscopy of the cast blood vessels showed distortion and destruction of alveolar capillaries prohibiting the passage of erythrocytes. Large new capillaries developed on top of, and were connected to, the shrivelled capillaries that ...
Looking for online definition of alveolar-capillary membrane in the Medical Dictionary? alveolar-capillary membrane explanation free. What is alveolar-capillary membrane? Meaning of alveolar-capillary membrane medical term. What does alveolar-capillary membrane mean?
The purpose of this study was to characterize blood-brain barrier (BBB) transport of oxycodone, a cationic opioid agonist, via the pyrilamine transporter, a putative organic cation transporter, using conditionally immortalized rat brain capillary endothelial cells (TR-BBB13). Oxycodone and [3H]pyrilamine were both transported into TR-BBB13 cells in a temperature- and concentration-dependent manner with Km values of 89 and 28 microM, respectively. The initial uptake of oxycodone was significantly enhanced by preloading with pyrilamine and vice versa. Furthermore, mutual uptake inhibition by oxycodone and pyrilamine suggests that a common mechanism is involved in their transport. Transport of both substrates was inhibited by type II cations (quinidine, verapamil, and amantadine), but not by classic organic cation transporter (OCT) substrates and/or inhibitors (tetraethylammonium, 1-methyl-4-phenylpyridinium, and corticosterone), substrates of OCTN1 (ergothioneine) and OCTN2 (L-carnitine), or ...
NASCIF, Ana K. S. et al. Inflammatory myopathies in childhood: correlation between nailfold capillaroscopy findings and clinical and laboratory data. J. Pediatr. (Rio J.) [online]. 2006, vol.82, n.1, pp.40-45. ISSN 0021-7557. http://dx.doi.org/10.2223/JPED.1435.. OBJECTIVE: Nailfold capillaroscopy is an important tool for the diagnosis and follow-up of patients with rheumatic diseases, in particular dermatomyositis and scleroderma. A relationship has been observed in adults between improved capillaroscopic findings and reduced disease activity. Our aim was to correlate disease activity (clinical and laboratory data) and nailfold capillaroscopy findings in 18 patients with inflammatory myopathies. METHODS: This prospective study included 13 juvenile dermatomyositis patients (Bohan and Peter criteria) (mean age of 8.8 years) and five patients with overlap syndrome (mean age of 15.7 years). We evaluated disease activity (skin abnormalities and muscle weakness, muscle enzymes and acute phase ...
Low prices on Grape Seed Extract! Grape seed extract strengthens veins, improves skin and combats free radicals*. Grape seed capsules provide concentrated amounts of oligomeric proanthocyanidins (OPC), a type of flavonoid complex. Grape seed extract and grape seed oil can support healthy collagen, veins and capillary structures. The powerful antioxidants in grape seed extract also act as free radical scavengers.* Get the antioxidant effect of grapes by taking grape seed extract daily!

Capillary Hemangioma Differential DiagnosesCapillary Hemangioma Differential Diagnoses

Capillary hemangiomas are one of the most common benign orbital tumors of infancy. They are benign endothelial cell neoplasms ... encoded search term (Capillary%20Hemangioma) and Capillary Hemangioma What to Read Next on Medscape. Medscape Consult. ... Capillary Hemangioma Differential Diagnoses. Updated: Oct 06, 2015 * Author: Stuart Seiff, MD, FACS; Chief Editor: Hampton Roy ... Periocular capillary hemangioma: management practices in recent years. Clin Ophthalmol. 2013. 7:1227-32. [Medline]. [Full Text] ...
more infohttps://emedicine.medscape.com/article/1218805-differential

Systemic capillary leak syndrome - Mayo ClinicSystemic capillary leak syndrome - Mayo Clinic

Systemic capillary leak syndrome is a rare disorder characterized by recurrent flares of massive leakage of plasma and other ... The systemic capillary leak syndrome: A case series of 28 patients from a European registry. Annals of Internal Medicine 2011; ... Systemic capillary leak syndrome may be triggered by an upper respiratory tract infection. Signs and symptoms of systemic ... One study reports that it is caused by chemicals in the body that damage or temporarily separate the cells lining the capillary ...
more infohttps://www.mayoclinic.org/diseases-conditions/systemic-capillary-leak-syndrome/basics/definition/con-20036701?p=1

CiNii 論文 - 
 		
 		
 			
 		 	
 		 		
 		 			Systemic Capillary Leak Syndrome
 		 		
 		 		
 		 	
 		
 	CiNii 論文 - Systemic Capillary Leak Syndrome

Systemic Capillary Leak Syndrome * * Kawabe Shotetsu KAWABE Shotetsu * the Department of Internal Medicine, Nagaoka Red Cross ... Systemic capillary leak syndrome and monoclonal IgG gammopathy; studies in a sixth patient and a review of the literature ... Systemic capillary leak syndrome with monoclonal IgG and complement alterations. A case report on an episodic syndrome LOFDAHL ... Capillary leak syndrome associated with elevated IL-2 serum levels after allogeneic bone marrow transplantation FUNKE I. ...
more infohttp://ci.nii.ac.jp/naid/10008034482

Capillary tubing - definition of capillary tubing by The Free DictionaryCapillary tubing - definition of capillary tubing by The Free Dictionary

Noun 1. capillary tubing - a tube of small internal diameter; holds liquid by capillary action capillary, capillary tube ... capillary tubing synonyms, capillary tubing pronunciation, capillary tubing translation, English dictionary definition of ... capillary tubing - a tube of small internal diameter; holds liquid by capillary action. capillary, capillary tube ... The system is run in conjunction with DynaCoil capillary injection tubing using specially engineered capillary tubing equipment ...
more infohttp://www.thefreedictionary.com/capillary+tubing

Microfluidic Capillary Electrophoresis SystemsMicrofluidic Capillary Electrophoresis Systems

Automated microfluidics capillary electrophoresis systems provide rapid alternative to slab gel analysis. Size and quantitate ... Automated microfluidic capillary electrophoresis (micro-CE) takes the concept of traditional gel separations and produces ... DNA and RNA quantitation and sizing can be done in seconds using automated capillary electrophoresis separation. The LabChip® ... The LabChip® GXII Touch makes protein quantitation fast with capillary electrophoretic separation. Detect, quantitate, and ...
more infohttp://www.perkinelmer.com/category/microfluidic-capillary-electrophoresis-systems

Systemic Capillary Leak SyndromeSystemic Capillary Leak Syndrome

... Ruri CHIHARA1), Hidetomo NAKAMOTO1), Hiroshi ARIMA1), Kenshi MORIWAKI1), Yoshihiko KANNO1), ... Systemic capillary leak syndrome (SCLS) is characterized by recurrent hypovolemic shock attributable to increased systemic ... capillary leakage. A 46-year-old man was admitted to our hospital because of recurrent episodes of generalized edema with ...
more infohttps://www.jstage.jst.go.jp/article/internalmedicine1992/41/11/41_11_953/_article

Lobular capillary hemangiomaLobular capillary hemangioma

Cutaneous lobular capillary hemangiomas appear to have a slight predilection for males, whereas mucosal lobular capillary ... Vulvar lobular capillary hemangiomas have also been reported. Drugs associated with periungual lobular capillary hemangiomas ... Lobular capillary hemangioma. Subscriber Sign In VisualDx Mobile Feedback Select Language Share Enter a Symptom, Medication, or ... Lobular capillary hemangioma in Adult. See also in: External and Internal Eye,Hair and Scalp,Nail and Distal Digit,Oral Mucosal ...
more infohttps://www.visualdx.com/visualdx/diagnosis/lobular-capillary-hemangioma?moduleId=11&diagnosisId=51646

Capillary fragility legal definition of capillary fragilityCapillary fragility legal definition of capillary fragility

What is capillary fragility? Meaning of capillary fragility as a legal term. What does capillary fragility mean in law? ... Definition of capillary fragility in the Legal Dictionary - by Free online English dictionary and encyclopedia. ... redirected from capillary fragility). Also found in: Dictionary, Thesaurus, Medical, Encyclopedia.. Related to capillary ... Capillary fragility legal definition of capillary fragility https://legal-dictionary.thefreedictionary.com/capillary+fragility ...
more infohttp://legal-dictionary.thefreedictionary.com/capillary+fragility

The Systemic Capillary Leak Syndrome | Annals of Internal Medicine | American College of PhysiciansThe Systemic Capillary Leak Syndrome | Annals of Internal Medicine | American College of Physicians

The systemic capillary leak syndrome (SCLS) can be a dramatic, perplexing, and terrifying disease to treat, particularly in its ... The Systemic Capillary Leak Syndrome Bert A. Govig, MD; Sepehr Javaheri, MD ... Govig BA, Javaheri S. The Systemic Capillary Leak Syndrome. Ann Intern Med. 2010;153:764. doi: 10.7326/0003-4819-153-11- ...
more infohttp://annals.org/aim/article/746548/systemic-capillary-leak-syndrome

The Systemic Capillary Leak Syndrome | Annals of Internal Medicine | American College of PhysiciansThe Systemic Capillary Leak Syndrome | Annals of Internal Medicine | American College of Physicians

The very interesting review on the systemic capillary leakage of circulating macromolecules (1) suggests capillary dysfunction ... The Systemic Capillary Leak Syndrome. Ann Intern Med. 2010;153:764. doi: 10.7326/0003-4819-153-11-201012070-00015 ...
more infohttp://annals.org/aim/article-abstract/746549/systemic-capillary-leak-syndrome

Systemic capillary leak syndrome revealing a diffuse large B-cell lymphomaSystemic capillary leak syndrome revealing a diffuse large B-cell lymphoma

Systemic capillary leak syndrome,, Aged, Capillary Leak Syndrome, Female, Humans, Lymphoma, Large B-Cell, Diffuse, 1101 Medical ... suggestive of systemic capillary leak syndrome (SCLS). Further investigations led to a diagnosis of diffuse large B-cell ... Systemic capillary leak syndrome, Non-Hodgkin lymphoma, PATIENT, DISEASE, SERUM, SHOCK, ...
more infohttps://lirias.kuleuven.be/1918798?limo=0

Validation of a Capillary Electrophoresis Method for Analyzing Chlorphenamine Maleate-Based Drugs Using the Accuracy Profile...Validation of a Capillary Electrophoresis Method for Analyzing Chlorphenamine Maleate-Based Drugs Using the Accuracy Profile...

... for the assay of chlorphenamine maleate by capillary electrophoresis. The validation was done using concentrations ranging ... "Validation of a Capillary Electrophoresis Method for Analyzing Chlorphenamine Maleate-Based Drugs Using the Accuracy Profile ...
more infohttps://scirp.org/journal/papercitationdetails.aspx?paperid=66557&JournalID=203

Role of the pulsed dye laser in the management of ulcerated capillary haemangiomas. | Archives of Disease in ChildhoodRole of the pulsed dye laser in the management of ulcerated capillary haemangiomas. | Archives of Disease in Childhood

A complication of capillary haemangiomas is ulceration, which may arise after trauma and/or infection. Until recently, ... It is therefore recommended that if ulcerated capillary haemangiomas do not improve after a short period of optimal ... Thirteen cases of ulcerated capillary haemangiomas referred to our department were reviewed; five were treated conservatively ... Role of the pulsed dye laser in the management of ulcerated capillary haemangiomas. ...
more infohttp://adc.bmj.com/content/74/2/161

Capillary Electrophoresis-Mass Spectrometry for Clinical Metabolomics | Read by QxMDCapillary Electrophoresis-Mass Spectrometry for Clinical Metabolomics | Read by QxMD

Relevance and use of capillary coatings in capillary electrophoresis-mass spectrometry. C Huhn, R Ramautar, M Wuhrer, G W ... Metabolite fingerprinting by capillary electrophoresis-mass spectrometry. Antonia Garcia, Shama Naz, Coral Barbas Methods in ... In clinical metabolomics, capillary electrophoresis-mass spectrometry (CE-MS) has become a very useful technique for the ... Capillary Electrophoresis-Mass Spectrometry for Clinical Metabolomics. Rawi Ramautar. Advances in Clinical Chemistry 2016, 74: ...
more infohttps://read.qxmd.com/read/27117659/capillary-electrophoresis-mass-spectrometry-for-clinical-metabolomics

Blood Capillary Function - HUMAN ANATOMY LESSONBlood Capillary Function - HUMAN ANATOMY LESSON

... capillary blood vessel function, function of blood capillary, function of blood capillary in skin, function of blood capillary ... blood capillaries in skin function, blood capillaries structure and function, blood capillary function, blood capillary tube ... Blood Capillary Function - See more about Blood Capillary Function, ... Tags: #blood capillaries in skin function #blood capillaries structure and function #blood capillary function #blood capillary ...
more infohttp://humananatomylesson.com/blood-capillary-function/

Quantitative metabolome analysis using capillary electrophoresis mass spectrometry | Read by QxMDQuantitative metabolome analysis using capillary electrophoresis mass spectrometry | Read by QxMD

A new approach for the comprehensive and quantitative analysis of charged metabolites by capillary electrophoresis mass ... Quantitative metabolome analysis using capillary electrophoresis mass spectrometry. Tomoyoshi Soga, Yoshiaki Ohashi, Yuki Ueno ...
more infohttps://read.qxmd.com/read/14582645/quantitative-metabolome-analysis-using-capillary-electrophoresis-mass-spectrometry

CAPILLARY HEMANGIOMA OF THE COLUMELLA OF NOSE | AbstractCAPILLARY HEMANGIOMA OF THE COLUMELLA OF NOSE | Abstract

Capillary hemangioma is a common condition but a capillary hemangioma arising from the columella of the nose is rare. Here we ... Capillary hemangioma is a common condition but a capillary hemangioma arising from the columella of the nose is rare. Here we ... CAPILLARY HEMANGIOMA OF THE COLUMELLA OF NOSE. Author(s): Muthubabu K, Sakthivel M, Srinivasan MK, Kalpana G, Twinkle ... Histopathological examination showed features suggestive of capillary hemangioma, the case was presented here due to rare ...
more infohttp://www.ijmrhs.com/abstract/capillary-hemangioma-of-the-columella-of-nose-1122.html

Integrated multiplexed capillary electrophoresis system by Edward S. Yeung and Hongdong Tan"Integrated multiplexed capillary electrophoresis system" by Edward S. Yeung and Hongdong Tan

The system integrates and automates multiple components, such as chromatographic columns and separation capillaries, and ... further provides a detector for the detection of analytes eluting from the separation capillaries. The system employs ... The present invention provides an integrated multiplexed capillary electrophoresis system for the analysis of sample analytes. ... The present invention provides an integrated multiplexed capillary electrophoresis system for the analysis of sample analytes. ...
more infohttp://lib.dr.iastate.edu/patents/156/

CapillariesCapillaries

The fluid flows toward the venule side of the capillary, where it reenters the capillary and circulates through venules and ... is only wide enough to allow one blood cell to pass through the capillary at a time. The narrow lumen and thin capillary walls ... Capillaries are the smallest and most common blood vessels in the human body. They are vital in the process of exchange of ... Capillaries are found in almost every tissue of the body, where they form a microscopic network of passages between an ...
more infohttps://www.innerbody.com/anim/blood.html

Capillary - WikipediaCapillary - Wikipedia

Individual capillaries are part of the capillary bed, an interweaving network of capillaries supplying tissues and organs. The ... Sinusoid capillaries (also known as a discontinuous) are a special type of open-pore capillary, that have larger openings (30- ... Capillary blood sampling is generally performed by creating a small cut using a blood lancet, followed by sampling by capillary ... Lymph capillaries have a greater internal oncotic pressure than blood capillaries, due to the greater concentration of plasma ...
more infohttps://en.wikipedia.org/wiki/Capillaries

Capillary - WikipediaCapillary - Wikipedia

Sinusoidal capillaries or discontinuous capillaries are a special type of open-pore capillary, also known as a sinusoid,[14] ... Individual capillaries are part of the capillary bed, an interweaving network of capillaries supplying tissues and organs. The ... These capillaries are a constituent of the blood-brain barrier.[9]. Fenestrated[edit]. Fenestrated capillaries have pores known ... Capillary blood sampling is generally performed by creating a small cut using a blood lancet, followed by sampling by capillary ...
more infohttps://en.wikipedia.org/wiki/Capillary

Brain Capillaries | SpringerLinkBrain Capillaries | SpringerLink

Since glial cells are in close contact with brain capillaries in situ,... ... Capillary Endothelial Cell Tissue Culture Dish Bovine Aortic Endothelial Cell Brain Capillary Endothelial Cell Cellular Protein ... Since glial cells are in close contact with brain capillaries in situ, communication between glial cells and capillary ... Del Vecchio P. J., Ryan V. S., and Ryan J. W. (1977) Isolation of capillary segments from rat adrenal gland. J. Cell Biol. 75, ...
more infohttps://link.springer.com/protocol/10.1385%2F0-89603-214-0%3A353

Capillary MalformationsCapillary Malformations

Information on capillary malformations, including diagnosis, treatment and complications, provided by Cincinnati Childrens ... Capillary Malformations A capillary malformation (commonly referred to as a port-wine stain), is a flat, sharply defined ... Another capillary vascular lesion, called nevus simplex, is mostly seen in newborns and is often confused with capillary ... When the capillary malformation involves the forehead and/or upper eyelid, abnormalities of the eye and/or brain may be present ...
more infohttps://www.cincinnatichildrens.org/health/c/capillary

The Dermal Lymphatic Capillaries | SpringerLinkThe Dermal Lymphatic Capillaries | SpringerLink

... of lymphatic capillaries. It is an account of our experience in the evaluation of dermal lymphatics in normal, edematous, and ...
more infohttps://link.springer.com/book/10.1007%2F978-3-642-73480-9
  • The symptoms result from a sudden and unexplained increase in the leakiness of small blood vessel (capillary) walls. (mayoclinic.org)
  • One study reports that it is caused by chemicals in the body that damage or temporarily separate the cells lining the capillary walls. (mayoclinic.org)
  • Capillary haemangioma of the eyelids and orbit: a clinical review of the safety and efficacy of intralesional steroid. (medscape.com)
  • Continuous capillaries are continuous in the sense that the endothelial cells provide an uninterrupted lining, and they only allow smaller molecules , such as water and ions to pass through their intercellular clefts . (wikipedia.org)
  • Fenestrated (derived from fenestra , Latin for "window") capillaries have pores in the endothelial cells (60-80 nm in diameter) that are spanned by a diaphragm of radially oriented fibrils and allow small molecules and limited amounts of protein to diffuse. (wikipedia.org)
  • Fenestrated capillaries have pores known as fenestrae ( Latin for "windows") in the endothelial cells that are 60-80 nm in diameter. (wikipedia.org)
  • Since glial cells are in close contact with brain capillaries in situ , communication between glial cells and capillary endothelial cells is thought to be important in maintaining homeostasis within the central nervous system. (springer.com)
  • Folkman J., Haudenschild C. C., and Zetter B. R. (1979) Long term culture of capillary endothelial cells. (springer.com)
  • These capillaries lack pinocytotic vesicles, and therefore utilize gaps present in cell junctions to permit transfer between endothelial cells, and hence across the membrane. (wikipedia.org)
  • Capillaries are found in almost every tissue of the body, where they form a microscopic network of passages between an arteriole and a venule. (innerbody.com)
  • Precapillary sphincters made of smooth muscle surround capillaries on their arteriole ends to control the flow of blood into each individual capillary and regulate the distribution of oxygen and nutrients within the body. (innerbody.com)
  • In the renal system, peritubular capillaries are tiny blood vessels, supplied by the efferent arteriole, that travel alongside nephrons allowing reabsorption and secretion between blood and the inner lumen of the nephron. (wikipedia.org)
  • This blood leaves the glomerulus via the efferent arteriole, which supplies the peritubular capillaries. (wikipedia.org)
  • Water is also driven into the peritubular capillaries due to the higher fluid pressure of the interstitium, driven by reabsorption of fluid and electrolytes via active transport, and the low fluid pressure of blood entering the peritubular capillaries due to the narrowness of the efferent arteriole. (wikipedia.org)
  • Electrophoretic separations carried out in capillary tubes offer the possibilities of rapid and automated analyses of small volumes of complex mixtures with unprecedented resolution and sensitivity. (sciencemag.org)
  • A high voltage isolated switching arrangement switches the end of the capillary from the injection block to buffer at a high electrical potential to accomplish the electrophoretic separation. (freepatentsonline.com)
  • These capillaries are a constituent of the blood-brain barrier . (wikipedia.org)
  • Bags containing barrier spray did not reduce contamination medical waste should be clearly identified as errors in capillary blood collection protocols.11-13 such. (cdc.gov)
  • The blood containers, alcohol swabs, and barrier following procedure for collecting capillary sprays) must be lead-free. (cdc.gov)
  • Capillary haemangioma of the eyelids and orbit: a clinical review of the safety and efficacy of intralesional steroid. (medscape.com)
  • Peritubular capillaries surround the proximal and distal tubules, as well as the loop of Henle, where they are known as vasa recta. (wikipedia.org)
  • and being used successfully to collect capillary blood from young children. (cdc.gov)
  • Unlike the velocity of gravity waves, the velocity of capillary waves increases with decreasing wavelength, the minimum velocity being 23.1 centimetres per second (9.09 inches per second), where the wavelength is the maximum 1.73 cm. (britannica.com)
  • Of all the patients who eventually develop capillary hemangiomas, 30% of them have evidence of their presence at birth, while 100% have manifest them by age 6 months. (medscape.com)
  • Capillary wave , small, free, surface-water wave with such a short wavelength that its restoring force is the water's surface tension , which causes the wave to have a rounded crest and a V-shaped trough. (britannica.com)
  • What I mean for 'capillary distribution' is a distribution all around the world also in small villages. (usingenglish.com)
  • Transmission electron microscope image of a cross-section of a capillary occupied by a red blood cell. (wikipedia.org)
  • The occurrence of capillary malformations is unrelated to drugs or medications that may have been taken during pregnancy or to environmental exposures that may have occurred at that time. (cincinnatichildrens.org)
  • Capillary malformations in the skin directly overlying the spine can be associated with spinal abnormalities such as tethering of the spinal cord and should be investigated with an ultrasound or MRI. (cincinnatichildrens.org)
  • The usual location of capillary blood sampling is the skin of the finger or heel. (medlineplus.gov)
  • Tap directly onto capillaries with your fingertip or a makeup brush and blend into surrounding skin. (prevention.com)
  • Capillary blood sampling may result in inaccurate results, such as falsely elevated sugar, electrolyte, and blood count values. (medlineplus.gov)