Capgras Syndrome: A psychotic disorder characterized by the patient's belief that acquaintances or closely related persons have been replaced by doubles or imposters.Lewy Body Disease: A neurodegenerative disease characterized by dementia, mild parkinsonism, and fluctuations in attention and alertness. The neuropsychiatric manifestations tend to precede the onset of bradykinesia, MUSCLE RIGIDITY, and other extrapyramidal signs. DELUSIONS and visual HALLUCINATIONS are relatively frequent in this condition. Histologic examination reveals LEWY BODIES in the CEREBRAL CORTEX and BRAIN STEM. SENILE PLAQUES and other pathologic features characteristic of ALZHEIMER DISEASE may also be present. (From Neurology 1997;48:376-380; Neurology 1996;47:1113-1124)Extrapyramidal Tracts: Uncrossed tracts of motor nerves from the brain to the anterior horns of the spinal cord, involved in reflexes, locomotion, complex movements, and postural control.Hallucinations: Subjectively experienced sensations in the absence of an appropriate stimulus, but which are regarded by the individual as real. They may be of organic origin or associated with MENTAL DISORDERS.Delusions: A false belief regarding the self or persons or objects outside the self that persists despite the facts, and is not considered tenable by one's associates.Neuropsychological Tests: Tests designed to assess neurological function associated with certain behaviors. They are used in diagnosing brain dysfunction or damage and central nervous system disorders or injury.Lewy Bodies: Intracytoplasmic, eosinophilic, round to elongated inclusions found in vacuoles of injured or fragmented neurons. The presence of Lewy bodies is the histological marker of the degenerative changes in LEWY BODY DISEASE and PARKINSON DISEASE but they may be seen in other neurological conditions. They are typically found in the substantia nigra and locus coeruleus but they are also seen in the basal forebrain, hypothalamic nuclei, and neocortex.PubMed: A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.BooksPublishing: "The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.MEDLINE: The premier bibliographic database of the NATIONAL LIBRARY OF MEDICINE. MEDLINE® (MEDLARS Online) is the primary subset of PUBMED and can be searched on NLM's Web site in PubMed or the NLM Gateway. MEDLINE references are indexed with MEDICAL SUBJECT HEADINGS (MeSH).Serial Publications: Publications in any medium issued in successive parts bearing numerical or chronological designations and intended to be continued indefinitely. (ALA Glossary of Library and Information Science, 1983, p203)Biological Science Disciplines: All of the divisions of the natural sciences dealing with the various aspects of the phenomena of life and vital processes. The concept includes anatomy and physiology, biochemistry and biophysics, and the biology of animals, plants, and microorganisms. It should be differentiated from BIOLOGY, one of its subdivisions, concerned specifically with the origin and life processes of living organisms.Schizophrenia: A severe emotional disorder of psychotic depth characteristically marked by a retreat from reality with delusion formation, HALLUCINATIONS, emotional disharmony, and regressive behavior.Drive: A state of internal activity of an organism that is a necessary condition before a given stimulus will elicit a class of responses; e.g., a certain level of hunger (drive) must be present before food will elicit an eating response.Schizophrenic Psychology: Study of mental processes and behavior of schizophrenics.Antipsychotic Agents: Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus.Schizophrenia, Paranoid: A chronic form of schizophrenia characterized primarily by the presence of persecutory or grandiose delusions, often associated with hallucination.Psychotic Disorders: Disorders in which there is a loss of ego boundaries or a gross impairment in reality testing with delusions or prominent hallucinations. (From DSM-IV, 1994)Psychiatric Status Rating Scales: Standardized procedures utilizing rating scales or interview schedules carried out by health personnel for evaluating the degree of mental illness.

Capgras syndrome: a clinical manifestation of watershed cerebral infarct complicating the use of extracorporeal membrane oxygenation. (1/11)

Ischaemic cerebral accidents are frequent following extracorporeal membrane oxygenation (ECMO), especially after fixing the reinjection cannula in the right primitive carotid artery, which leads to an interruption in downstream flow. We describe a rare and unusual symptom of cerebral ischaemic accident that is known as Capgras syndrome. This feature is interesting because it may be documented by computed tomography (CT) scan and particular electroencephalography signals. It appears that our observation represents the first documented case of Capgras syndrome complicating ECMO. This incident emphasizes the potential hazards associated with right common artery ligature for venoarterial extracorporeal membrane oxygenation (VAECMO). In addition, it shows that this psychiatric symptom (that has been interpreted psychodynamically for many years) can have an organic basis, which should be studied.  (+info)

Capgras' syndrome in dementia with Lewy bodies. (2/11)

We report the occurrence of Capgras' syndrome, or the delusion of doubles, in a patient with dementia with Lewy bodies. The patient believed that several similar-looking impostors had replaced his wife of over 50 years. Uncharacteristically, he adopted a friendly attitude with these impostors. This unusual convivial reaction to the impostors may result from differential involvement of the dual visual pathways processing facial recognition and emotional responses to faces. The delusion resolved spontaneously, coincident with worsening of the dementia. In a retrospective chart review of 18 autopsy-confirmed cases of dementia with Lewy bodies, delusions were reported in 5 subjects (27.8%), of whom 1 had misidentification delusions much like Capgras' syndrome.  (+info)

Schizophrenia and monothematic delusions. (3/11)

Numerous delusions have been studied which are highly specific and which can present in isolation in people whose beliefs are otherwise entirely unremarkable - "monothematic delusions" such as Capgras or Cotard delusions. We review such delusions and summarize our 2-factor theory of delusional belief which seeks to explain what causes these delusional beliefs to arise initially and what prevents them being rejected after they have arisen. Although these delusions can occur in the absence of other symptoms, they can also occur in the context of schizophrenia, when they are likely to be accompanied by other delusions and hallucinations. We propose that the 2-factor account of particular delusions like Capgras and Cotard still applies even when these delusions occur in the context of schizophrenia rather than occurring in isolation.  (+info)

Capgras' syndrome with organic disorders. (4/11)

Capgras' syndrome, one form of the delusional misidentification syndromes, is described. Three patients with the syndrome are reported. The first had a right cerebral infarction, the second had nephrotic syndrome secondary to severe pre-eclampsia in the puerperium, and the third had uncontrolled diabetes mellitus with dementia. Evidence is reviewed regarding an organic aetiology for Capgras' syndrome. We conclude that, when the syndrome is present, a thorough search for organic disorder should be made.  (+info)

Capgras syndrome in Dementia with Lewy Bodies. (5/11)


Shared delusions of doubles. (6/11)

This is the first report of two partners in a folie a deux situation manifesting identical Capgras delusions. It is postulated that the Capgras syndrome developed as a result of interaction between a dominant patient with primarily paranoid psychopathology and a submissive one with primarily organic dysfunction. The submissive "neuro-organic" partner experienced a non-delusional misidentification that acquired a delusional component and developed into the Capgras syndrome as a result of elaboration by the dominant paranoid partner, who subsequently "imposed" the Capgras delusion on the submissive partner. The submissive patient, and, to a lesser extent the dominant patient, had evidence of organic cerebral dysfunction.  (+info)

Responses to facial and non-facial stimuli presented tachistoscopically in either or both visual fields by patients with the Capgras delusion and paranoid schizophrenics. (7/11)

An experiment was carried out designed primarily to test A B Joseph's suggestion that patients with Capgras delusion may have problems integrating information between the two cortical hemispheres; and at the same time it was meant to examine J Cutting's ideas linking schizophrenia in general, and the Capgras delusion in particular, to right hemisphere dysfunction. Three patients with the Capgras delusion and three matched controls diagnosed as paranoid schizophrenics were briefly presented pairs of line-drawn object and photographs of faces randomly in the left visual field, the right visual field or bilaterally. The results with objects revealed no particular pattern of performance for either group; but, when faces were shown, the controls revealed the usual left visual field/right hemisphere advantage while for the Capgras group this was reversed. The results are not consistent with a simple prediction from Joseph's hypothesis but they are in accord with Cutting's theory-though they also pose some problems for it, which are discussed.  (+info)

Migraine madness: recurrent psychosis after migraine. (8/11)

A 69 year old man with longstanding migraine with aura had four episodes of psychosis lasting 7-28 days during a 17 year period. During attacks he had formed visual hallucination and delusions, including reduplicative paramnesia. His mother was similarly affected. His EEG showed symmetrical frontal delta waves. The time course and EEG changes are similar to acute confusional migraine. The reduplicative paramnesia suggests a focal non-dominant hemisphere dysfunction.  (+info)

  • People who experience this syndrome will have an irrational belief that someone they know or recognize has been replaced by an imposter. (
  • Caring for someone with Capgras syndrome can be emotionally demanding, especially if you're the one they perceive as the imposter. (
  • In Capgras syndrome, the individual believes that an imposter has taken the place of an important person in their life. (
  • Researchers at the Pearl I. Barlow Center for Memory Evaluation and Treatment at the New York University Medical Center evaluated 55 patients with DLB, 11 of who had Capgras syndrome. (
  • Early diagnosis of DLB and Capgras syndrome may allow for early pharmacological intervention and an opportunity to reduce caregiver burden and depression," stated Dr. James E. Galvin, who designed the study and served as senior author. (
  • Recent research investigated whether there is an association with other DLB symptoms and Capgras syndrome. (
  • there were no differences seen in self-reported depression symptoms and no relationship was found between Capgras syndrome and parkinsonism. (
  • According to the Genetic and Rare Diseases Information Center, the symptoms of Ambras syndrome, as the condition is also called, include excessive hair growth all over the body, except on the palms of the hands and soles of the feet. (
  • The etiology of Capgras in Parkinson's remains unclear, but may arise from a combination of factors, such as frontal lobe dysfunction and dopaminergic medication. (
  • Capgras may also be observed in Parkinson's Disease (PD) [ 12 , 13 ], and may arise as a consequence of dopaminergic medication and frontal lobe dysfunction. (
  • Zoocentric Capgras, the variant we describe, has been rarely described in scientific literature, and we believe it is of interest due to its unusual characteristics. (
  • Capgras delusion is a condition where the patient believes that someone has been replaced by an identical double. (
  • 1 The Capgras delusion is a condition in which a person believes that either an individual or a group of people has been replaced by doubles or imposters. (
  • Be sure to report Capgras syndrome to your loved one's physician for proper evaluation and treatment. (
  • Treatment of Walking Corpse syndrome varies by patient and the underlying disorders they suffer from. (
  • Until recently, it wasn't known exactly what caused these syndromes to occur but new work from neuroscientists at Beth Israel Deaconess Medical Center (BIDMC) has shown that brain lesions, which injure brain tissue, are present in these disorders and are likely connected. (
  • The poet john cowper was afflicted with capgras syndrome, fr goli , an italian actor of the cell membrane, depolarization, resting potential. (
  • We present a case of transient Capgras syndrome following bilateral cerebral ischemic infarcts in the frontal, parietal, and temporal regions, and involving the right prefrontal cortex. (
  • While the exact cause of Capgras syndrome is unknown, it may result from an injury to the brain. (
  • Capgras syndrome could also be caused by a disconnect between the visual part of the brain and the area that processes facial familiarity. (
  • There's something wrong with the brain, but why and how is Capgras syndrome occurring because of it? (
  • The syndrome was, at first, the intellectual property of scientists for whom the mind had little to do with the brain. (
  • im not sure this sort of thing always (or even usually) is accompanied by brain damage. (
  • While laying out the basics of neuroanatomy and neurochemistry, Professor Reisberg uses Capgras syndrome as a multipage case study to demonstrate how neuroscientists study the brain and they have learned about its operating principles. (
  • It's likely people with regular Capgras have brain damage to a different pathway, called the covert pathway, which sustains familiarity. (
  • They say that their patient is unique, however, because he is the first case of animal Capgras associated with verifiable brain injury. (
  • In Richard Powers's novel The Echo Maker, a young man suffers a brain injury in an auto accident and is afflicted with Capgras syndrome. (
  • Transient Capgras Syndrome Secondary to Bilateral Ischemic Stroke: A Case Report. (
  • A 2015 study looked at a case of Capgras syndrome that was related to hypothyroidism , or an underactive thyroid gland, so hormonal imbalances may also be a risk factor. (
  • In one isolated case, the Capgras delusion was temporarily induced in a healthy subject by the drug ketamine . (
  • The patient was initially described as having an unusual case of Marfan syndrome with renal abnormalities at age 7 years. (
  • 7. Sathe H, Karia S, De Sousa A, Shah N. Capgras syndrome: a case report. (
  • The following two case reports are examples of the Capgras delusion in a psychiatric setting: Mrs. D, a 74-year-old married housewife, recently discharged from a local hospital after her first psychiatric admission, presented to our facility for a second opinion. (
  • But the authors of the new case report, who are all neurologists and psychiatrists at the University Hospital of Tours, said that atypical Capgras is likely more complicated. (
  • Behavioral Manifestations of Sturge-Weber Syndrome: A Case Report. (
  • Could this really be a case of feline Capgras? (