Cantharidin: A toxic compound, isolated from the Spanish fly or blistering beetle (Lytta (Cantharis) vesicatoria) and other insects. It is a potent and specific inhibitor of protein phosphatases 1 (PP1) and 2A (PP2A). This compound can produce severe skin inflammation, and is extremely toxic if ingested orally.Beetles: INSECTS of the order Coleoptera, containing over 350,000 species in 150 families. They possess hard bodies and their mouthparts are adapted for chewing.Okadaic Acid: A specific inhibitor of phosphoserine/threonine protein phosphatase 1 and 2a. It is also a potent tumor promoter. (Thromb Res 1992;67(4):345-54 & Cancer Res 1993;53(2):239-41)Phosphoprotein Phosphatases: A group of enzymes removing the SERINE- or THREONINE-bound phosphate groups from a wide range of phosphoproteins, including a number of enzymes which have been phosphorylated under the action of a kinase. (Enzyme Nomenclature, 1992)Copulation: Sexual union of a male and a female in non-human species.Cobra Cardiotoxin Proteins: Most abundant proteins in COBRA venom; basic polypeptides of 57 to 62 amino acids with four disulfide bonds and a molecular weight of less than 7000; causes skeletal and cardiac muscle contraction, interferes with neuromuscular and ganglionic transmission, depolarizes nerve, muscle and blood cell membranes, thus causing hemolysis.Molluscum Contagiosum: A common, benign, usually self-limited viral infection of the skin and occasionally the conjunctivae by a poxvirus (MOLLUSCUM CONTAGIOSUM VIRUS). (Dorland, 27th ed)Molluscum contagiosum virus: A species of MOLLUSCIPOXVIRUS causing skin lesions in humans. It is transmitted by direct contact or from non-living reservoirs (fomites), such as books or clothing.North CarolinaSouth CarolinaPoxviridae: A family of double-stranded DNA viruses infecting mammals (including humans), birds and insects. There are two subfamilies: CHORDOPOXVIRINAE, poxviruses of vertebrates, and ENTOMOPOXVIRINAE, poxviruses of insects.Chemokine CCL27: A CC-type chemokine with specificity for CCR10 RECEPTORS. It is constitutively expressed in the skin and may play a role in T-CELL trafficking during cutaneous INFLAMMATION.Acantholysis: Separation of the prickle cells of the stratum spinosum of the epidermis, resulting in atrophy of the prickle cell layer. It is seen in diseases such as pemphigus vulgaris (see PEMPHIGUS) and DARIER DISEASE.Warts: Benign epidermal proliferations or tumors; some are viral in origin.Mustard Gas: Severe irritant and vesicant of skin, eyes, and lungs. It may cause blindness and lethal lung edema and was formerly used as a war gas. The substance has been proposed as a cytostatic and for treatment of psoriasis. It has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP-85-002, 1985) (Merck, 11th ed).Pemphigus: Group of chronic blistering diseases characterized histologically by ACANTHOLYSIS and blister formation within the EPIDERMIS.Norepinephrine: Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic.Muscle, Smooth: Unstriated and unstriped muscle, one of the muscles of the internal organs, blood vessels, hair follicles, etc. Contractile elements are elongated, usually spindle-shaped cells with centrally located nuclei. Smooth muscle fibers are bound together into sheets or bundles by reticular fibers and frequently elastic nets are also abundant. (From Stedman, 25th ed)Muscle, Smooth, Vascular: The nonstriated involuntary muscle tissue of blood vessels.Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.Dose-Response Relationship, Drug: The relationship between the dose of an administered drug and the response of the organism to the drug.Endothelium, Vascular: Single pavement layer of cells which line the luminal surface of the entire vascular system and regulate the transport of macromolecules and blood components.Vasodilation: The physiological widening of BLOOD VESSELS by relaxing the underlying VASCULAR SMOOTH MUSCLE.Blister: Visible accumulations of fluid within or beneath the epidermis.Bandages: Material used for wrapping or binding any part of the body.Electronic Mail: Messages between computer users via COMPUTER COMMUNICATION NETWORKS. This feature duplicates most of the features of paper mail, such as forwarding, multiple copies, and attachments of images and other file types, but with a speed advantage. The term also refers to an individual message sent in this way.Spindle Apparatus: A microtubule structure that forms during CELL DIVISION. It consists of two SPINDLE POLES, and sets of MICROTUBULES that may include the astral microtubules, the polar microtubules, and the kinetochore microtubules.Mitosis: A type of CELL NUCLEUS division by means of which the two daughter nuclei normally receive identical complements of the number of CHROMOSOMES of the somatic cells of the species.Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.Chromosome Segregation: The orderly segregation of CHROMOSOMES during MEIOSIS or MITOSIS.Veterinary Medicine: The medical science concerned with the prevention, diagnosis, and treatment of diseases in animals.Dictionaries, MedicalDictionaries as Topic: Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.Ear, External: The outer part of the hearing system of the body. It includes the shell-like EAR AURICLE which collects sound, and the EXTERNAL EAR CANAL, the TYMPANIC MEMBRANE, and the EXTERNAL EAR CARTILAGES.Ear: The hearing and equilibrium system of the body. It consists of three parts: the EXTERNAL EAR, the MIDDLE EAR, and the INNER EAR. Sound waves are transmitted through this organ where vibration is transduced to nerve signals that pass through the ACOUSTIC NERVE to the CENTRAL NERVOUS SYSTEM. The inner ear also contains the vestibular organ that maintains equilibrium by transducing signals to the VESTIBULAR NERVE.Ear, Inner: The essential part of the hearing organ consists of two labyrinthine compartments: the bony labyrinthine and the membranous labyrinth. The bony labyrinth is a complex of three interconnecting cavities or spaces (COCHLEA; VESTIBULAR LABYRINTH; and SEMICIRCULAR CANALS) in the TEMPORAL BONE. Within the bony labyrinth lies the membranous labyrinth which is a complex of sacs and tubules (COCHLEAR DUCT; SACCULE AND UTRICLE; and SEMICIRCULAR DUCTS) forming a continuous space enclosed by EPITHELIUM and connective tissue. These spaces are filled with LABYRINTHINE FLUIDS of various compositions.Optical Storage Devices: A computer disk read by a laser beam, containing data prerecorded by a vendor. The buyer cannot enter or modify data in any way but the advantages lie in the speed of accessibility, relative immunity to damage, and relatively low cost of purchase.Condylomata Acuminata: Sexually transmitted form of anogenital warty growth caused by the human papillomaviruses.Podophyllin: Caustic extract from the roots of Podophyllum peltatum and P. emodi. It contains PODOPHYLLOTOXIN and its congeners and is very irritating to mucous membranes and skin. Podophyllin is a violent purgative that may cause CNS damage and teratogenesis. It is used as a paint for warts, skin neoplasms, and senile keratoses.Face: The anterior portion of the head that includes the skin, muscles, and structures of the forehead, eyes, nose, mouth, cheeks, and jaw.Genital Diseases, Male: Pathological processes involving the male reproductive tract (GENITALIA, MALE).Cryotherapy: A form of therapy consisting in the local or general use of cold. The selective destruction of tissue by extreme cold or freezing is CRYOSURGERY. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Anus DiseasesMedicine, Chinese Traditional: A system of traditional medicine which is based on the beliefs and practices of the Chinese culture.Medicine, East Asian Traditional: Medical practice or discipline that is based on the knowledge, cultures, and beliefs of the people in EAST ASIA.Drugs, Chinese Herbal: Chinese herbal or plant extracts which are used as drugs to treat diseases or promote general well-being. The concept does not include synthesized compounds manufactured in China.China: A country spanning from central Asia to the Pacific Ocean.Quality Control: A system for verifying and maintaining a desired level of quality in a product or process by careful planning, use of proper equipment, continued inspection, and corrective action as required. (Random House Unabridged Dictionary, 2d ed)Caustics: Strong alkaline chemicals that destroy soft body tissues resulting in a deep, penetrating type of burn, in contrast to corrosives, that result in a more superficial type of damage via chemical means or inflammation. Caustics are usually hydroxides of light metals. SODIUM HYDROXIDE and potassium hydroxide are the most widely used caustic agents in industry. Medically, they have been used externally to remove diseased or dead tissues and destroy warts and small tumors. The accidental ingestion of products (household and industrial) containing caustic ingredients results in thousands of injuries per year.Complement Pathway, Alternative: Complement activation initiated by the interaction of microbial ANTIGENS with COMPLEMENT C3B. When COMPLEMENT FACTOR B binds to the membrane-bound C3b, COMPLEMENT FACTOR D cleaves it to form alternative C3 CONVERTASE (C3BBB) which, stabilized by COMPLEMENT FACTOR P, is able to cleave multiple COMPLEMENT C3 to form alternative C5 CONVERTASE (C3BBB3B) leading to cleavage of COMPLEMENT C5 and the assembly of COMPLEMENT MEMBRANE ATTACK COMPLEX.Plant Epidermis: A thin layer of cells forming the outer integument of seed plants and ferns. (Random House Unabridged Dictionary, 2d ed)Burns, ChemicalEsophageal Stenosis: A stricture of the ESOPHAGUS. Most are acquired but can be congenital.

The protein phosphatase inhibitor cantharidin induces head and foot formation in buds of Cassiopea andromeda (Rhizostomae, Scyphozoa). (1/89)

The polyps of Cassiopea andromeda produce spindle shaped, freely swimming buds which do not develop a head (a mouth opening surrounded by tentacles) and a foot (a sticky plate at the opposite end) until settlement to a suited substrate. The buds, therewith, look very similar to the planula larvae produced in sexual reproduction. With respect to both, buds and planulae, several peptides and the phorbolester TPA have been found to induce the transformation into a polyp. Here it is shown that cantharidin, a serine/threonine protein phosphatase inhibitor, induces head and foot formation in buds very efficiently in a 30 min treatment, the shortest yet known efficient treatment. Some resultant polyps show malformations which indicate that a bud is ordinary polyp tissue in which preparatory steps of head and foot formation mutually block each other from proceeding. Various compounds related to the transfer of methyl groups have been shown to affect head and foot formation in larvae of the hydrozoon Hydractinia echinata. These compounds including methionine, homocysteine, trigonelline, nicotinic acid and cycloleucine are shown to also interfere with the initiation of the processes which finally lead to head and foot formation in buds of Cassiopea andromeda.  (+info)

The protein phosphatase inhibitor cantharidin alters vascular endothelial cell permeability. (2/89)

In this study, we characterized the effects of the protein phosphatases type 1 (PP 1) and type 2A (PP 2A) inhibitor cantharidin in endothelial cells. We identified catalytic subunits of PP 1alpha, PP 2Aalpha, and PP 2Abeta immunologically in bovine aortic endothelial cells. Moreover, we detected mRNAs coding for catalytic subunits of PP 1alpha, PP 1beta, and PP 2Aalpha by hybridization with specific DNA probes in total RNA from these cells. Okadaic acid and cantharidin inhibited the activities of catalytic subunits of PP 1 (okadaic acid, 0.01-1 microM; cantharidin, 1-100 microM) and PP 2A (okadaic acid, 0.1 nM to 1 microM; cantharidin, 0.1-100 microM) separated by column chromatography in a concentration-dependent manner. Moreover, cantharidin (1 microM to 1 mM) increased the phosphorylation state of endothelial proteins including the regulatory light chains of myosin without affecting cytosolic calcium concentrations. Cantharidin (5-100 microM) increased the permeability of cultured endothelial cells in a time- and concentration-dependent manner. We suggest that inhibition of PP 1 and PP 2A activities by cantharidin increases endothelial permeability by enhancing the phosphorylation state of endothelial regulatory proteins. Thus, cantharidin might be a useful tool to study the function of protein phosphatases in endothelial barrier function.  (+info)

Penetration of moxifloxacin into peripheral compartments in humans. (3/89)

To characterize the penetration of moxifloxacin (BAY 12-8039) into peripheral target sites, the present study aimed at measuring unbound moxifloxacin concentrations in the interstitial space fluid by means of microdialysis, an innovative clinical sampling technique. In addition, moxifloxacin concentrations were measured in cantharides-induced skin blisters, saliva, and capillary plasma and compared to total- and free-drug concentrations in venous plasma. For this purpose, 12 healthy volunteers received moxifloxacin in an open randomized crossover fashion either as a single oral dose of 400 mg or as a single intravenous infusion of 400 mg over 60 min. An almost-complete equilibration of the free unbound plasma fraction of moxifloxacin with the interstitial space fluid was observed, with mean area under the concentration-time curve (AUC)(interstitial fluid)/AUC(total-plasma) ratios ranging from 0.38 to 0.55 and mean AUC(interstitial fluid)/AUC(free-plasma) ratios ranging from 0.81 to 0.86. The skin blister concentration/plasma concentration ratio reached values above 1.5 after 24 h, indicating a preferential penetration of moxifloxacin into inflamed lesions. The moxifloxacin concentrations in saliva and capillary blood were similar to the corresponding levels in plasma. Our data show that moxifloxacin concentrations attained in the interstitial space fluid in humans and in skin blister fluid following single doses of 400 mg exceed the values for the MIC at which 90% of isolates are inhibited for most clinically relevant bacterial strains, notably including penicillin-resistant Streptococcus pneumoniae. These findings support the use of moxifloxacin for the treatment of soft tissue and respiratory tract infections in humans.  (+info)

A study to determine the pharmacokinetics and inflammatory fluid penetration of gatifloxacin following a single oral dose. (4/89)

A single 400 mg oral dose of gatifloxacin was given to each of nine healthy male volunteers and the concentrations of the drug in plasma, cantharidine-induced inflammatory fluid and urine were measured over the following 24 h. The mean peak concentration in plasma of 4. 1 mg/L was attained at a mean time of 1.8 h post dose. The mean peak concentration in inflammatory fluid was 3.6 mg/L and was attained at a mean time of 4.2 h post dose. The mean plasma elimination half-life of gatifloxacin was 6.8 h and that in inflammatory fluid was 7.2 h. The mean penetration into the inflammatory fluid was 117%. Recovery of drug from urine during the first 24 h post dose was 65% of that administered. Our data suggest that gatifloxacin dosed at 400 mg od should be adequate to treat systemic infections caused by most bacterial species.  (+info)

Phosphatase inhibitor cantharidin blocks adenosine A(1) receptor anti-adrenergic effect in rat cardiac myocytes. (5/89)

Experiments were performed to examine whether the protein phosphatase inhibitor cantharidin blocks the anti-adrenergic effect of adenosine A(1) receptor stimulation. In electrically stimulated adult rat ventricular myocytes loaded with the intracellular calcium concentration ([Ca(2+)](i)) indicator fluo-3, isoproterenol (10 nM) increased systolic [Ca(2+)](i) by 46%, increased twitch amplitude by 56%, and increased total cellular cAMP content by 140%. The adenosine A(1) receptor agonist 2-chloro-N(6)-cyclopentlyadenosine (CCPA) reduced isoproterenol-stimulated [Ca(2+)](i) and contractility by 87 and 80%, respectively, but reduced cAMP content by only 18%. Cantharidin had no effects on myocyte [Ca(2+)](i), contractility, or cAMP in the absence or presence of isoproterenol but blocked the effects of CCPA on [Ca(2+)](i) and contractility by approximately 44%. Cantharidin had no effect on CCPA attenuation of isoproterenol-induced increases in cAMP. Pretreatment with CCPA also reduced the increase in contractile parameters produced by the direct cAMP-dependent protein kinase A (PKA) activator 8-bromocAMP. These results suggest that activation of protein phosphatases mediate, in part, the anti-adrenergic effect of adenosine A(1) receptor activation in ventricular myocardium.  (+info)

Hamster pancreatic beta cell lines with altered sensitivity towards apoptotic signalling by phosphatase inhibitors. (6/89)

Specific inhibitors of serine/threonine phosphatases like okadaic acid can induce apoptotic cell death in the pancreatic beta cell line HIT. Cultivation in stepwise increased concentrations of okadaic acid enabled the isolation of HIT100R cells which proliferate at 100 nM okadaic acid (8 - 10 times the initially lethal concentration). These two cell lines were used to characterize the events triggered by okadaic acid that led to apoptosis. Biochemical markers, e.g. cytochrome c release from mitochondria and increase of caspase-3-like activity, revealed that induction of apoptosis by 100 nM okadaic acid in parental HIT cells started with the release of cytochrome c. In HIT100R cells 500 nM okadaic acid were necessary to induce alterations comparable to those observed with 100 nM okadaic acid in non-resistant HIT cells. In contrast to okadaic acid, the potency of the structurally different phosphatase inhibitor cantharidic acid to induce cytochrome c release, increase of caspase-3-like activity and DNA fragmentation was comparable in HIT and HIT100R cells. Thus, no cross-resistance between these phosphatase inhibitors seemed to exist. Phosphatase activity in extracts from HIT and HIT100R cells did not differ in its total amount or in its sensitivity for okadaic acid. Since higher concentrations of okadaic acid were needed to induce apoptosis in HIT100R cells, a compromised intracellular accumulation of the toxin appeared likely. Functional and structural analysis revealed that this was achieved by the development of the multidrug resistance phenotype in HIT100R cells. The underlying mechanism appeared to be the enhanced expression of the pgp1 but not the pgp2 gene.  (+info)

Protein phosphatase inhibitors arrest cell cycle and reduce branching morphogenesis in fetal rat lung cultures. (7/89)

Protein phosphatase 2A (PP2A) is a key signal transduction intermediate in the regulation of cellular proliferation and differentiation in vitro. However, the role of PP2A in the context of a developing organ is unknown. To explore the role of PP2A in the regulation of lung development, we studied the effect of PP2A inhibition on new airway branching, induction of apoptosis, DNA synthesis, and expression of epithelial marker genes in whole organ explant cultures of embryonic (E14) rat lung. Microdissected lung primordia were cultured in medium containing one of either two PP2A inhibitors, okadaic acid (OA, 0-9 nM) or cantharidin (Can, 0-3,600 nM), or with the PP2B inhibitor deltamethrin (Del, 0-10 microM) as a control for a PP2A-specific effect for 48 h. PP2A inhibition with OA and Can significantly inhibited airway branching and overall lung growth. PP2B inhibition with Del did not affect lung growth or new airway development. Histologically, both PP2A- and PP2B-inhibited explants were similar to controls. Increased apoptosis was not the mechanism of decreased lung growth and new airway branching inasmuch as OA-treated explant sections subjected to the terminal deoxynucleotidyltransferase dUTP nick end labeling reaction demonstrated a decrease in apoptosis. However, PP2A inhibition with OA increased DNA content and 5-bromo-2'-deoxyuridine uptake that correlated with a G(2)/M cell cycle arrest. PP2A inhibition also resulted in altered differentiation of the respiratory epithelium as evidenced by decreased mRNA levels of the early epithelial marker surfactant protein C. These findings suggest that inhibition of protein phosphatases with OA and Can halted mesenchymal cell cycle progression and reduced branching morphogenesis in fetal rat lung explant culture.  (+info)

Cantharidin enhances norepinephrine-induced vasoconstriction in an endothelium-dependent fashion. (8/89)

In this study we characterized the effects of the protein phosphatase (PP) type 1 and type 2A inhibitor cantharidin (Cant) and its structural analogs cantharidic acid and endothall on PP activity, force of contraction, and myosin light chain phosphorylation in rat aorta. All compounds inhibited PP activity in homogenates of rat aorta with a rank order of potency of Cant = cantharidic acid > endothall. However, only Cant increased force of contraction and myosin light chain phosphorylation in intact isolated rat aortic rings. Based on these findings, we investigated the effects of Cant on alpha-adrenoceptor-mediated vasoconstriction. Cant (1 and 3 microM) enhanced norepinephrine-induced contraction in endothelium-intact rat aorta. In contrast, Cant did not affect norepinephrine-induced contraction in endothelium-denuded rat aorta. We suggest that inhibition of PP1 and/or PP2A activities by Cant enhances vascular contractility in endothelium-intact rat aorta by increasing the phosphorylation state of endothelial regulatory proteins.  (+info)

Cantharidin side effects - What is cantharidin wart treatment? Cantharidin. Your doctor "paints" cantharidin on your wart and covers it with a bandage. This is generally painless. The cantharidin causes the skin under the wart to blister, lifting the wart off the skin. When the blister dries, the wart comes off with the blistered skin. You may feel some pain when the skin blisters. When you see your doctor again, he or she will remove the dead skin and may retreat.
Herbal medicine is one of the forms of traditional medical practice. Traditional Chinese medicine (TCM) and traditional Vietnamese medicine (TVM) are well-known for their long-standing tradition of herbal medicine. Secreted by many species of blister beetle, most notably by the Spanish fly (Lytta vesicatoria), cantharidin inhibits protein phosphatases 1 and 2A (PP1, PP2A). Blister beetle has been used in Asian traditional medicine to treat Molluscum contagiosum virus (MCV) infections and associated warts, and is now also used for cancer treatment. A combination of both genomic and postgenomic techniques was used in our studies to identify candidate genes affecting sensitivity or resistance to cantharidin. Cantharidin was not found to be related to multidrug resistance phenotype, suggesting its potential usefulness for the treatment of refractory tumors. Oxidative stress response genes diminish the activity of cantharidin by inducing DNA strand breaks which may be subject to base excision repair and
Looking for Cantharidin? Find out information about Cantharidin. C10H12O4 Colorless crystals that melt at 218°C; slightly soluble in acetone, chloroform, alcohol, and water; used in veterinary medicine. Also known as... Explanation of Cantharidin
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Topically administered cantharidin induces increased release of MIP-2, MCP-1, KC, IL-6, IL-1b, MPO and neutrophil accumulation in ear tissue. Sixteen hours after cantharidin application, ear swelling is observed, persisiting for the next 7 days.. The activity of test compounds is evaluated by ear weighing (main read-out). Ear tissue and other selected tissues can be stored for subsequent analyses (facultative read-outs). ...
Adults are omnivorous, often feeding on pollen (taking part in flower pollination) or plant exudates; cases of micropredation have also been registered. Most Notoxinae prefer sandy soils for laying eggs. Many species, particularly of Notoxus, are known to be canthariphilous and are attracted to cantharidin. The cantharidin is mostly obtained by males. In some groups, males bear secretory glands that concentrate the cantharidin in special canals or pits at the elytral apices, indicated as apical tubercles. Being highly poisonous, cantharidin is used by Notoxinae as a feeding deterrent against predators or acts as a kairomone for braconid wasps, endoparasites of Notoxus. Females take the cantharidin into their bodies when feeding upon the secretions of the males. Females also pass the cantharidin to the eggs and larvae and it is used for protection by them. ...
Blister beetles produce cantharidin, a poisonous substance comparable to cyanide and strychnine in toxicity. Stored in the insects blood, the compound is stable and remains toxic even in beetle carcasses. Animals may be poisoned by ingesting beetles while grazing or eating harvested silage. Cantharidin can also cause severe skin inflammation and blisters.. Cantharidin is absorbed through the intestine and can cause symptoms such as inflammation, colic, straining, elevated temperature, depression, increased heart rate and respiration, dehydration, sweating, and diarrhea. There is frequent urination during the first 24 hours after ingestion, accompanied by inflammation of the urinary tract. This irritation may also result in secondary infection and bleeding. Taken internally, as little as 10 milligrams can be fatal in humans.. The concentration of cantharidin in adult beetles depends primarily on the sex; males produce the chemical and only pass on small amounts to the females during mating. ...
Blister beetles produce cantharidin, a poisonous substance comparable to cyanide and strychnine in toxicity. Stored in the insects blood, the compound is stable and remains toxic even in beetle carcasses. Animals may be poisoned by ingesting beetles while grazing or eating harvested silage. Cantharidin can also cause severe skin inflammation and blisters.. Cantharidin is absorbed through the intestine and can cause symptoms such as inflammation, colic, straining, elevated temperature, depression, increased heart rate and respiration, dehydration, sweating, and diarrhea. There is frequent urination during the first 24 hours after ingestion, accompanied by inflammation of the urinary tract. This irritation may also result in secondary infection and bleeding. Taken internally, as little as 10 milligrams can be fatal in humans.. The concentration of cantharidin in adult beetles depends primarily on the sex; males produce the chemical and only pass on small amounts to the females during mating. ...
In this study, the specific contribution of polyamine oxidase (PAO), a hydrogen peroxide (H₂O₂)-producing enzyme, to the oxidative burst induced in maize mesocotyl by the phosphatase inhibitor cantharidin was examined. For this purpose, a pharmacological approach was applied using, either in vitro or in vivo, two strong inhibitors of maize PAO (MPAO), N-prenylagmatine (G3) and its structural analogue Ro5, as well as diphenyleneiodonium (DPI), an inhibitor of the phagocyte NAD(P)H oxidase. DPI was shown to be a good MPAO inhibitor in vitro. G3, Ro5, and DPI were very effective in inhibiting in vivo the extracellular accumulation of H₂O₂ that is released by mesocotyl segments upon spermidine supply. G3 and Ro5 did not show any inhibition in vitro of either horseradish peroxidase or barley oxalate oxidase. Moreover, G3 and Ro5 did not inhibit the extracellular accumulation of superoxide radical that is released in vivo upon NADH supply. G3, Ro5, and DPI strongly affected H₂O₂ production ...
Spanish fly doesnt actually come from a fly. It is made from the cantharides beetle, also called the blister beetle, or Cantharis vesicatoria. The name comes from an intense irritant they generate as a defense mechanism. The beetles are collected, killed, dried and powdered, and the result is called Spanish fly.. Cantharides, being a natural inflammatory agent, can burn the mouth and throat and cause abdominal pain, vomiting, diarrhea and kidney damage even in small doses. It also strongly irritates the genito-urinary tract, and sex is one way to calm that itch. The stories regarding medical application of cantharides would be listed as "not to be believed," except that they are true. In 1752 a Frenchman was prescribed 2 drams of cantharides for a fever and in the next two months bedded his wife at least 87 times. Another man with a similar prescription "knew his wife", as the Bible puts it, 40 times in one night.. As little as one thousandth of an ounce of the active chemical in cantharides is ...
Background: Cantharidin is a topical vesicant that causes intraepidermal acantholysis with clinical application that includes the removal of warts, molluscum contagiosum (MC), calluses, and acquired perforating dermatoses. Objective: To provide a com
This is one beautiful Blister Beetle in the family Meloidae and the colors on your image, the bold black and white beetle, the orange antennae and the ultraviolet purple blossom are stunning. We quickly identified a similar looking Blister Beetle on the Kenya Natural History Guide that is identified as being in the genus Mylabris. The site states: "Many blister beetles are so toxic to mammals that ingestion of a few may be enough to kill a horse. It happens occasionally when the beetles get wrapped up into a bale of hay, quite by accident. Birds somehow just know that a beetle with this pattern should never be eaten, and they leave them alone. There are many, many species of Mylabris distributed across Africa, Europe and Asia." Once we had a genus name, we identified the species on Beetles of Africa and confirmed the identification on iSpot. ...
Blister beetle, (family Meloidae), any of approximately 2,500 species of beetles (insect order Coleoptera) that secrete an irritating substance, cantharidin, which is collected mainly from Mylabris and the European species Lytta vesicatoria, commonly called Spanish fly. Cantharidin is used
Bean blister beetle on a plant stem. Blister beetles (family Meloidae) are so called for their defensive secretion of the chemical cantharidin, which causes blistering of the skin. Photographed on Nanao island, Guangdong, China. - Stock Image C019/7962
Blister beetles excrete a toxic blistering agent called cantharidin, which can cause irritation and blistering when it comes in contact with the eyes, skin, mouth, throat, or digestive tract. The irritation and blisters that form can be painful but usually are not life-threatening. Blister beetles are notorious for their ancient use as an aphrodisiac. Not only is such use groundless, it can also be fatal.
Cantharis Vesicatoria.). Common name.- Spanish Fly.. General Analysis.-. Cantharis acts especially upon the mucous membranes and upon the skin.. Its decidedly most important action is upon the mucous lining of the urinary tract, where it produces conditions ranging all the way from an irritation to a violent destructive inflammation, either of a part or of the whole tract.. The mucous membrane of the digestive tract is also involved in an inflammatory condition.. On the skin the irritative action of Cantharis results in an erysipelatous form of inflammation, and vesicular conditions in general.. The chief characteristic of this drug is its constant urging to urinate, scanty discharge, and violent cutting, burning pains before, during, and after the discharge.. Characteristic symptoms.. Mind.- (Cantharis). Anxious restlessness, ending in rage.. Constant, complete, furious, almost frenzied delirium. (Bell., Hyos., Oenan., Stram.). Insolent and contradictory mood. (Bry., Nux v.). Head.- ...
When you kill a blister beetle by crushing it against your skin, a poison in the beetles body causes a painful blister. The blisters are only the beginning of the many problems that these insects cause. In this article, youll learn about blister beetle control.
References:. Arnett, R.H., Jr., M.C. Thomas, P.E. Skelley & J.H. Frank. (editors). 2002. American Beetles, Volume II: Polyphaga: Scarabaeoidea through Curculionoidea. CRC Press. 861 pp.. Borror, D.J. 1960. Dictionary of Word Roots and Combining Forms. National Press Books, Palo Alto. 134 pp.. Brown, W.D. 1990. Size-assortative mating in the blister beetle Lytta magister (Coleoptera: Meloidae) is due to male and female preference for larger mates. Animal Behaviour 40: 901-909. Selander, R.B. 1960. Bionomics, Systematics, and Phylogeny of Lytta, a Genus of Blister Beetles (Coleoptera: Meloidae). Illinois Biological Monographs: Number 28. 295 pp.. White. R.E. 1983. A Field Guide to the Beetles of North America. Houghton Mifflin Company, Boston. 368 pp.. ...
Blister beetles are aptly named, for when they are disturbed they emit a yellow, oily, defensive secretion (cantharidin) from their joints which usually causes blisters when it comes in contact with skin. This toxin deters many potential predators and is especially effective against ants. According to naturalist/forester/writer Ginny Barlow, as little as 100 milligrams is…
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An update on my post of July 4…. Weve had 4 invasions of blister beetles this summer. 2 were major, 100s or 1000s of bugs, in repeated waves, lasted for several days - turned parts of the garden to sticks within a few hours; and 2 invasions were minor (maybe fewer than 100 beetles) and quickly wiped out. Ive now seen 3 species of blister beetles: (a) one thats mostly grey with a little black, and these come in herds; (b) one thats black with small orange triangles on the abdomen behind the wing covers, and these are solitary - just a few at a time; and (c) one thats yellow & brown striped on its back; these were the most common in Missouri when I lived there; Ive seen only a few of them late in the summer here in Arkansas.. …about the Pyrethrins: The brand is "Bonide" concentrate, 1% pyrethrin. We ordered this thru the local Ace Hardware - $20.99 for 8 ounces - and now the local health food store carries it in their garden section. Since then, Ive Googled "Bonide pyrethrin"; found ...
An update on my post of July 4…. Weve had 4 invasions of blister beetles this summer. 2 were major, 100s or 1000s of bugs, in repeated waves, lasted for several days - turned parts of the garden to sticks within a few hours; and 2 invasions were minor (maybe fewer than 100 beetles) and quickly wiped out. Ive now seen 3 species of blister beetles: (a) one thats mostly grey with a little black, and these come in herds; (b) one thats black with small orange triangles on the abdomen behind the wing covers, and these are solitary - just a few at a time; and (c) one thats yellow & brown striped on its back; these were the most common in Missouri when I lived there; Ive seen only a few of them late in the summer here in Arkansas.. …about the Pyrethrins: The brand is "Bonide" concentrate, 1% pyrethrin. We ordered this thru the local Ace Hardware - $20.99 for 8 ounces - and now the local health food store carries it in their garden section. Since then, Ive Googled "Bonide pyrethrin"; found ...
BLISTER BEETLE BIOLOGY Blister beetles are commonly found in the yard and garden. Theyre a unique insect because they cause all kinds of reactions on peop
Recently I have had several samples of blister beetles brought into the office. They have been on a rampage in a few tomato patches recently. Blister beetles are about three quarters of an inch to an inch and a quarter long. They have narrow bodies, broad heads, and antennae that are about one-third the length of the entire body. There are three types or colors in Kentucky, jet black, striped with orange and black, and margined (which were brought in the office) that are black and have a thin gray stripe around the wing covers.
Recently I have had several samples of blister beetles brought into the office. They have been on a rampage in a few tomato patches recently. Blister beetles are about three quarters of an inch to an inch and a quarter long. They have narrow bodies, broad heads, and antennae that are about one-third the length of the entire body. There are three types or colors in Kentucky, jet black, striped with orange and black, and margined (which were brought in the office) that are black and have a thin gray stripe around the wing covers.
View Notes - Chemical Basis of Life F10 from BIOL 121 at University of Evansville. 3Biol 121 Anatomy and Physiology I Chemical Basis of Life I. Matter and Energy A. Matter - anything that occupies
The Canadian Food Inspection Agency is investigating the presence of Iron Cross Blister Beetles in imported leafy vegetables. Consumer complaints have alerted the agency to this issue. No illnesses or injuries have been reported at this time. The Iron Cross Blister beetle releases a chemical called "cantharidin" that can cause blisters on the skin. It has a bright red head and bright yellow markings on the wings, separated by a glass cross. This beetle should be treated with caution. Public health officials are waring consumers to wash and carefully look over their leafy vegetables throughly before serving and eating them. The beetle should be removed without touching it or crushing it. If you do find one, contact your local CFIA office. The beetle was found in pre-packaged salads … [Read more...] ...
Normally these beetles emerge in large numbers in mid to late spring and move together in bands crawling or running across the ground. They feed on succulent leaves and flower petals. The larva stage is subterranean and likely is parasitic in nests of ground-nesting bees.. Iron Cross Beetles conspicuous coloration is related to the fact that they carry cantharidin toxins that can interfer with the vertibrate nervous system - i.e. it is an aposemtic warning. In case you were wondering, you should not eat these insects. ...
Thank you for sharing this Molecular Cancer Therapeutics article.. NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.. ...
The family Oedemeridae includes pollen-feeding beetles that are commonly called false blister beetles in English. The Japanese name kamikiri-modoki means false longhorn (kamikiri). I found this specimen on a vending machine at night (near Inunaki Dam in Fukuoka).. ...
Although markings vary greatly depending on the species, blister beetles are easily identified by their physique: the middle section of the body is noticeably smaller than the head or abdomen. The majority of these pests are well under an inch long.. Life Cycle: Adults lay eggs beneath the soil, where the newly hatched grubs feed on grasshopper eggs. The grubs remain underground in a dormant state for up to 2 years, then become active, pupate, and emerge as plant- feeding adults in late spring or early Summer.. ...
University of Wisconsin - Madison Division of Extension Releases Blister Beetle Fact Sheet (Madison) University of Wisconsin - Madison Division of Extensio
Alex the horse and the blister beetles | Book 477426 by: Tyra easter theme: Open Theme format: 11x8.5 - Hardcover w/Glossy Laminate - Color - Photo Book
A story of blood, love, and family… Learn about one of the biggest and fanciest blister beetles anywhere. This species goes by the scientific name of Lytta magister but has also been called the
The present study was undertaken to determine whether the two ubiquitously expressed Ca(2+)-independent phosphatases PP1 and PP2A regulate Ca(2+)-activated Cl(-) currents (I(Cl(Ca))) elicited by 500 nM [Ca(2+)](i) in rabbit pulmonary artery (PA) myocytes dialyzed with or without 3 mM ATP. Reverse transcription-PCR experiments revealed the expression of PP1alpha, PP1beta/delta, PP1gamma, PP2Aalpha, PP2Abeta, PP2Balpha (calcineurin (CaN) Aalpha), and PP2Bbeta (CaN Abeta) but not PP2Bgamma (CaN Agamma) in rabbit PA. Western blot and immunofluorescence experiments confirmed the presence of all three PP1 isoforms and PP2A. Intracellular dialysis with a peptide inhibitor of calcineurin (CaN-AIP); the non-selective PP1/PP2A inhibitors okadaic acid (0.5, 10, or 30 nM), calyculin A (10 nM), or cantharidin (100 nM); and the selective PP1 inhibitor NIPP-1 (100 pM) potently antagonized the recovery of I(Cl(Ca)) in cells dialyzed with no ATP, whereas the PP2A-selective antagonist fostriecin (30 or 150 nM) was
Chattopadhyay D, Swingle MR, Salter EA, Wood E, DArcy B, Zivanov C, Abney K, Musiyenko A, Rusin SF, Kettenbach A, et al. Crystal structures and mutagenesis of PPP-family ser/thr protein phosphatases elucidate the selectivity of cantharidin and novel norcantharidin-based inhibitors of PP5C. Biochemical Pharmacology. 2016 ;109:14-26. ...
Chattopadhyay D, Swingle MR, Salter EA, Wood E, DArcy B, Zivanov C, Abney K, Musiyenko A, Rusin SF, Kettenbach A, et al. Crystal structures and mutagenesis of PPP-family ser/thr protein phosphatases elucidate the selectivity of cantharidin and novel norcantharidin-based inhibitors of PP5C. Biochemical Pharmacology. 2016 ;109:14-26. ...
The Chemical Basis of Life. Elements, Atoms and Molecules Waters Life-Supporting Properties Chemical Reactions. Living Organisms are Made of Elements. Living organisms composed of matter Matter: anything that occupies space and has mass Slideshow 1707293 by atira
Free flashcards to help memorize facts about CHEMICAL BASIS OF LIFE. Other activities to help include hangman, crossword, word scramble, games, matching, quizes, and tests.
|p class=p1|By Benjamin Espy, DVM, DACT|/p||p class=p1|Many horse owners feed alfalfa hay to supplement their horse and is a very efficient source of protein and calcium. Alfalfa hay requires very specific growing conditions and is primarily harvested in the western United States.
I live in Slovakia and i have never seen something like this bug.. it was about 5 centimeters long. What do you think about it ...
Experience the beauty and diversity of South African National Parks, Travel and explore South Africa! Nature Conservation, Accommodation, Activities, Reservations
Merck & Co., Inc., Kenilworth, NJ, USA is a global healthcare leader working to help the world be well. From developing new therapies that treat and prevent disease to helping people in need, we are committed to improving health and well-being around the world. The Merck Veterinary Manual was first published in 1955 as a service to the community. The legacy of this great resource continues as the Merck Veterinary Manual in the US and Canada and the MSD Manual outside of North America.. ...
An offshoot of FarmgirlFare.com, In My Kitchen Garden is all about the large kitchen garden on my remote Missouri farm: growing heirloom vegetables and herbs in raised beds, organic gardening and pest control, composting, growing tips, fresh seasonal recipes, greenhouse gardening, and more.
Project Noah is a tool that nature lovers can use to explore and document local wildlife and a common technology platform that research groups can use to harness the power of citizen scientists everywhere.
This Fly Is Of The Middle And South Of Europe | It Appears In The Month Of May And June | Specially On The White Popular | Privet | Ash-elder | Lilac Etc Upon The Leaves Of Which They Feed The Insect Is Of About Half An Inch Long | Of A Golden Yellow-gree
For each industry listed, one could list the primary product and then list what materials are used in that product. Every material is some form of chemical (metal alloy, compound or collection of compound). For example, the automobile industry produces cars - cars contain metal alloys such as steel which is an alloy of iron, carbon and other metals, plastics and polymers (some paneling and interior), glass (windshield, windows, and lamps/lights), and rubber (tires ...
Physical Matter Properties Chemical Matter Properties, Elements and Compounds, chemistry carbohydrates, Fats and Lipids, High School Biology
11. SNP (pronounced "snip") - Single Nucleotide Polymorphism. This is a mutation (change) in the marker of a nucleotide. Nucleotides are unique markers in the genome. For example the chemical basis G (Guanine) may change to a T (Thymine). This is done only once in this nucleotide, and these changes determine what haplogroup a person is. There is no harm to the species with this change. SNPs have unique names, such as M207 or P224. The test is either positive or negative for the particular SNP, and this helps determine where a tester is on the Phylogenetic Tree. A person can have a SNP test to determine the detailed twig on their haplogroup branch. That is, testing various SNPs helps determine if you are a U5 or a U5a1a. The more SNPs tested, the more detailed the haplogroup will be ...
1905-2002). Ukrainian-born US biochemist who became professor of biochemistry at Columbia University (1952-74). Stimulated by Oswald Averys identification of DNA as the basis of heredity in pneumococcus bacteria, he discovered that the constitution of DNA is consistent within a species but that there are as many types of DNA as there are species. However, his discovery that the number of purine bases is always equal to the number of pyrimidine bases, and that a similar relationship exists between adenine and thymine bases and between cytosine and guanine bases, provided Watson and Crick with an important clue in their elucidation of the chemical basis of heredity. ...
We took samples back to the lab and carefully inspected the larvae under a microscope. Using a dichotomous key, I was able to name the organisms down to genus. They were first instar larvae of the blister beetle (Meloe sp.). Now what on earth is a blister beetle and why is it hitching a ride on these bees? Is it harmful to bees? Could this be a new pest?. We did some investigating to find out. It turns out that blister beetle larvae are previously reported on bees and other pollinators in the US. Larvae of some Meloe species grab hold of pollinators while on flowers. In fact, theres a range of pollinators they attach to: solitary bees, wasps, flies, beetles…and honey bees. Some species parasitize bees by feeding on hemolymph, but their main purpose for interacting with pollinators remains a mystery. The fact that phoretic larvae use such a wide range of pollinators doesnt support the idea that they are using honey bees as hosts to parasitize. Researchers think that these larvae might be ...
This dataset contains the digitized treatments in Plazi based on the original journal article Cline, Andrew R., Huether, Jeffrey P. (2011): Revision of the nearctic blister beetle genus Tricrania LeConte, 1860 (Coleoptera: Meloidae: Nemognathinae). Zootaxa 2832: 1-43, DOI: 10.5281/zenodo.200535 ...
... are hydrocolloid pads bordered by a thin adhesive film. 2nd Skin blister pads help keep blisters from drying out, absorb perspiration and help promote a scab free naturally healed blister. These blister pads can also be applied to protect and cushion against blister formation. Spenco 2nd Skin blister pads can last up to 5 days. Box of 5. Spenco 2nd Skin - Blister Pads Feature: Latex free Stays in place up to 5 days Promotes a scab free, naturally healed blister Thin, sterile hydrocolloid pad with adhesive film
Cerebro-spinal meningitis : paroxysms of rage and fury ; pain deep in brain, with an expression of great suffering ; base of brain is chief seat of pain ; urine dribbles or passes with burning-cutting pain ...
Warts come and go at various stages of life like childhood and teenage years. They usually go away by themselves. But some can be very painful, can spread quickly and some of them wont go away for many years. Such kind of warts should definitely be treated. The most common treatment among the pediatricians is cryotherapy. They will freeze the warts using liquid nitrogen. Cantharidin can also be applied, which is a painless treatment but can result in painful blisters at the end of the day. The minus point is that these treatments sometimes cause blistering and some warts wont come off in one sitting. If the warts wont still budge they are further treated with strong salicylic acid, intralesional immune-therapy, bleomycin, or a pulsed dye laser. Aldara can also be used in worst cases. Because of some treatments the warts grow to the end of the blister, which results in a bigger wart and some might even result in a scar. ...
Beetle infestation often occur at the edges of gardens or in surrounding vegetation. Keep grass, weeds and other growth trimmed around the margins of your garden to remove the places where they might get started ...
Gatherer is the Magic Card Database. Search for the perfect addition to your deck. Browse through cards from Magics entire history. See cards from the most recent sets and discover what players just like you are saying about them.
Huge skin blisters hand - A 1-year-old female with blister on her left hand | Infectious Diseases.... Revitol Skin Brightener Cream is your safe, herbal-based solution for a beautiful, glowing complexion.
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From the perspective of evolutionary psychology the experiences and behaviors associated with love can be investigated in terms of how they have been shaped by human evolution. For example, it has been suggested that human language has been selected during evolution as a type of "mating signal" that allows potential mates to judge reproductive fitness. Miller described evolutionary psychology as a starting place for further research: "Cognitive neuroscience could try to localize courtship adaptations in the brain. Most importantly, we need much better observations concerning real-life human courtship, including the measurable aspects of courtship that influence mate choice, the reproductive (or at least sexual) consequences of individual variation in those aspects, and the social-cognitive and emotional mechanisms of falling in love." Since Darwins time there have been similar speculations about the evolution of human interest in music also as a potential signaling system for attracting and ...
Lust is the initial passionate sexual desire that promotes mating, and involves the increased release of chemicals such as testosterone and estrogen. These effects rarely last more than a few weeks or months. Attraction is the more individualized and romantic desire for a specific candidate for mating, which develops out of lust as commitment to an individual mate forms. Recent studies in neuroscience have indicated that as people fall in love, the brain consistently releases a certain set of chemicals, including pheromones, dopamine, norepinephrine, and serotonin, which act in a manner similar to amphetamines, stimulating the brains pleasure center and leading to side effects such as increased heart rate, loss of appetite and sleep, and an intense feeling of excitement. Research has indicated that this stage generally lasts from one and a half to three years.[14] ...
Advanced first aid.A hydrocolloid pad bordered by a thin film helps keep blisters from drying out, absorbs perspiration and helps promote a scab free,...
A pustule is also a small, defined elevation of the outer layer of the skin (epidermis) that is filled with pus - a mixture of white blood cells, cellular debris, dead tissue, and serum, the clear watery fluid that separates from the blood.
Background Norcantharidin (NCTD) is a Chinese FDA approved, chemically synthesized drug for cancer treatment. The effect of NCTD on signaling proteins of EGFR and c-Met was systematically elucidated...
Xeno nucleic acid (XNA) is a synthetic alternative to the natural nucleic acids DNA and RNA as information-storing biopolymers that differs in the sugar backbone. As of 2011, at least six types of synthetic sugars have been shown to form nucleic acid backbones that can store and retrieve genetic information. Research is now being done to create synthetic polymerases to transform XNA. The study of its production and application has created a field known as xenobiology. Although the genetic information is still stored in the four canonical base pairs (unlike other nucleic acid analogues), natural DNA polymerases cannot read and duplicate this information. Thus the genetic information stored in XNA is "invisible" and therefore useless to natural DNA-based organisms. The structure of the DNA was discovered in 1953 and many scientists assumed that our understandings for the chemical basis of life was perfect. However, around the early 2000s, researchers were able to create a number of exotic DNA-like ...
Students in this course will develop a better understanding of food, cooking, and nutrition using basic chemical concepts. Topics that will be discussed include the chemical basis of taste, flavor and aroma; the role of fermentation and chemical reactions in cooking, food, and beverage production; antioxidants and other macro- and micronutrients in the human diet; modern agricultural practices; and the economic, political and social justice issues surrounding the use of food and its availability. The laboratory portion of the course will focus on kitchen experimentation and cooking techniques, flavor pairing, and molecular gastronomy. (NSL ...
The infection appears as skin blisters which later break down to become superficial sores with golden-yellow "stuck on" crusts on the surface ...
Any blister kit should be assembled with 5 goals in mind: 1. keep your blister as pain-free as possible 2. stop your blister roof from tearing or deroofing 3. prevent your blister from getting infected 4. make your blister heal as quickly as possible 5. and even to stop your hotspot from becoming a blister in the first place
The blister channel provides you with various models of blister products wholesale supply information, including the parameters, models, pictures, prices, manufacturers and other information of blister machines. Accurate and comprehensive information on blister machines is available on the network 114.
There is disclosed a child resistant blister package comprising a conventional blister package having cavities containing unit doses of medication. The blister package is adapted to receive a locking member which is slidably secured to the blister package to effectively prevent children from accessing the medication therein and yet is readily, slidably removed from the blister package by an adult to access medication therefrom.
Blister Treatment Blueprint 2.0 [FREE GUIDE]: 5 step system to treating painful messy blisters and preventing infection, especially after popping your blister.
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... - Model: DPN L. Serial No: Year: Blister packing machine for hot or cold forming of mouldable films/foils. Up to 40 cycles per minute. NOACK BLISTER
See pricing info, deals and product reviews for Energizer Alkaline Max AAA / LR03 1.5 V Non-Rechargable Battery Blister of 4 (blister 4 each) at Staples.co.uk. Order online today and get fast, free shipping for your business.
Hiking Lady discusses blister treatment tips. Once you have blisters, there are several blister treatment options to help them heal quickly so you can get hiking pain free again!
When choosing a treatment for blisters, consider the severity of the blisters, the type of blisters that they are, the location...
A blister is a bubble of fluid under the skin. The clear, watery liquid inside a blister is called serum. It leaks in from neighboring tissues as a reaction…
The body produces blisters to protect damaged skin and help it heal. People should generally avoid popping them unless they are large or very painful. Learn when to pop a blister and how to do it safely here.
While the appearance of blisters may be embarrassing, the pain accompanying them is often much worse and more of a concern for people who have them. Read on to learn more about blisters!
While the appearance of blisters may be embarrassing, the pain accompanying them is often much worse and more of a concern for people who have them. Read on to learn more about blisters!
While the appearance of blisters may be embarrassing, the pain accompanying them is often much worse and more of a concern for people who have them. Read on to learn more about blisters!
Presentation of the Official Blister sets (KMS). The page provides high quality pictures, detailed description of each blister and other useful information (e.g. mintage, issue date etc)
Blister testo canzone cantato da Zimmers Hole: What are you fuckin lookin at? Im gonna rip out your fuckin eye Blister! Blistered eye ...
Presentation of the Official Blister sets (KMS) commemorating people or events. The page provides high quality pictures, detailed description of each blister and other useful information (e.g. mintage, issue date etc)
Blister Package & Blister Cards for retail products. The creative Andex team has the solution for you. Custom design and economical stock sizes available.
Its tempting, but should you pop a blister? Here the experts weigh in on whether or not its a good idea and offer a few alternative solutions.
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I have an old (1988) Zodiac S131 which has developed what I would describe a blister on one tube! It is as if there is a pinhole coming through the inner and mid layers so that the outer PVC layer is
... merupakan mesin yang digunakan untuk packing obat. Dalam penggunaannya mesin ini dgunakan untuk packing obat dalam bentuk kapsul dimana
My LO is 9 months and I have been back at work sice she was 10 weeks. I have pumped with essentially the same routine and results since returning to work. Two days ago I began to develop blisters around both nipples. All equipment and cleaning has remained the same. Any ideas on what could be causing this or how to mend my injured breasts?
Running blisters are unavoidable, but following some easy hacks to prevent them or treating them properly can come handy anytime. Run safely and happily.
Lots of us are currently dreaming of skiing and / or our next skis. But one of our Blister members schemed up a new custom ski, then gave it a great name: the Extra Crunchy PB&J. Check out the backstory & specs for this ECPB&J, and let us know about any dream builds youve thought up.
On-line prodej originálního příslušenství a mobilních telefonů. Detail produktu CC C200 HTC Autodobíječ microUSB (EU Blister)
Dit mes van Coast (serie FX 350) is veelzijdig inzetbaar, duurzaam en van hoogwaardig materiaal. Coast is in de VS een toonaangevend merk in LED-handlampen. Coast produceert technologisch hoogstaande producten (met vijf jaar garantie) waarmee de gebruiker
The University of North Carolina Department of Dermatology is conducting a clinical trial to evaluate a drug called cantharidin in the treatment of molluscum contagiosum. Molluscum is a common dermatologic disorder caused by a poxvirus. Molluscum typically presents with many flesh-colored bumps on the skin. It goes away on its own, though can last several months to several years. Cantharidin is a topical medicine which is applied at the clinic visit. It is well tolerated by the majority of children ...
The most common medicines for bladder infections are Cantharis and. Staphysagria.. • Think of Apis if the pain is mostly stinging and burning, there is any swelling, the last drops feel scalding, and the urine will not come out easily.. • Give Cantharis if blood in the urine is prominent or the pain is excruciating. Cantharis has the most extreme bladder symptoms.. • If the major symptom is frequent, intense urging with very severe pain, give Mercurius corrosivus .. • Sarsaparilla is a very common medicine for womens bladder infections .. • If the major symptom is burning in the urethra at the close of urination, give Sarsaparilla. If it doesnt work, look at Staphysagria or Cantharis.. • If the bladder infection comes on after sex, consider Staphysagria first.. Dosage ...
Kikunae Ikeda (池田 菊苗, Ikeda Kikunae, 8 October 1864 - 3 May 1936) was a Japanese chemist and Tokyo Imperial University professor of Chemistry who, in 1908, uncovered the chemical basis of a taste he named umami. It is one of the five basic tastes along with sweet, bitter, sour and salty. In 1907 at the Tokyo Imperial University in Japan, Professor Ikeda was eating dinner with his family when he suddenly stopped. That day the dashi broth in his soup was more delicious than normal; after stirring a few times he realized the difference was the umami flavor from the addition of kombu. He understood that kombu was the secret to that flavor, and from that day on he studied the chemical composition of kelp. By 1908, he had isolated brown crystals of glutamic acid (glutamate) which conveyed the characteristic flavor. The chemical monosodium glutamate (MSG) is the chemical basis for the umami flavor. He chose to call it Ajinomoto (味の素, "essence of flavor"). By 1909 he had developed a ...
Field trials were conducted to determine effects of cultivar and insecticide application on grain yield and yield loss of cowpea to insect pest during the 2008 and 2009 cropping seasons at Baga (13° 29ʺ N and 13° 32ʺ E), Lake Chad shore area of Nigeria. Three cowpea varieties (Kanannado, Borno brown and IT98k-1312), two insecticides [cypermethrin (30 g) + dimethoate (250 g) and neem seed aqueous extract] and three spray regimes (one each at budding, flowering and podding) were evaluated for the control of pest on cowpea. The treatments were laid in a strip-split plot design and replicated three times each. The results reveal that flower thrips (Megalurothrips sjostedti), Legume pod borer (Maruca vitrata), Blister beetle (Mylabris spp.) and Pod Sucking Bug (Anoplocnemi scurvipes) were the major insect pests of rainfed cowpea in the area. The variety Borno brown failed to produce flower in both seasons. IT98k-131-2 was more tolerant to damage by insect pests of budding, flowering and podding
Bezzerides A, Eisner T. 2002. Apportionment of nuptial alkaloidal gifts by a multiply-mated female moth (Utetheisa ornatrix): eggs individually receive alkaloid from more than one male source. Chemoecology 12(4): 213-218.. Bezzerides A, Yong T-H, Bezzerides J, Husseini J, Ladau J, Eisner M, Eisner T. 2004. Plant-derived pyrrolizidine alkaloid protects eggs of a moth (Utetheisa ornatrix) against a parasitoid wasp (Trichogramma ostriniae). Proceedings of the National Academy of Sciences USA 101(24): 9029-9032.. Bogner F, Eisner T. 1991. Chemical basis of egg cannibalism in a caterpillar (Utetheisa ornatrix). Journal of Chemical Ecology 17(11): 2063-2075.. Bogner F, Eisner T. 1992. Chemical basis of pupal cannibalism in a caterpillar (Utetheisa ornatrix). Experientia 48(1): 97-102.. Connor WE, Roach B, Benedict E, Meinwald J, Eisner T. 1990. Courtship pheromone production and body size as correlates of larval diets in males of the arctiid moth, Utetheisa ornatrix. Journal of Chemical Ecology 16(2): ...
Envenomization - Action of Venom Neurotoxin (black widow spider)Neurotoxin (black widow spider) Cytolytic, hemolytic (brown recluse spider)Cytolytic, hemolytic (brown recluse spider) Hemorrhagic (moth larvae)Hemorrhagic (moth larvae) Vesicating/blistering (blister beetles)Vesicating/blistering (blister beetles)
TY - JOUR. T1 - Neonatal pemphigus vulgaris. T2 - IgG4 autoantibodies to desmoglein 3 induce skin blisters in newborns. AU - Parlowsky, Thomas. AU - Welzel, Julia. AU - Amagai, Masayuki. AU - Zillikens, Detlef. AU - Wygold, Thorsten. PY - 2003/4/1. Y1 - 2003/4/1. N2 - We report a case of neonatal pemphigus vulgaris presenting with skin lesions on the head, genital area, and right foot. Pemphigus vulgaris was diagnosed by the presence of circulating autoantibodies predominantly of the IgG4 subtype by indirect immunofluorescence microscopy and by enzyme-linked immunosorbent assay using recombinant desmoglein 3. This case demonstrates the pathogenic relevance of IgG4 autoantibodies to desmoglein 3 in the skin of neonates.. AB - We report a case of neonatal pemphigus vulgaris presenting with skin lesions on the head, genital area, and right foot. Pemphigus vulgaris was diagnosed by the presence of circulating autoantibodies predominantly of the IgG4 subtype by indirect immunofluorescence microscopy ...
This study investigates the occurrence and regulation of serine/threonine protein phosphatases (PPases) in insulin-secreting RINm5F insulinoma cells. PPases types 1 and 2A were identified in crude RINm5F cell homogenates by both enzymatic assay and Western blot analysis. We then characterized and compared the inhibitory actions of several compounds isolated from cyanobacteria, marine dinoflagellates and marine sponges, (viz. okadaic acid, microcystin-LR, calyculin-A and nodularin) cation-independent PPase activities in RINm5F cell homogenates. It was found that okadaic acid was the least potent inhibitor (IC50 ≈ 10−9M, IC100 ≈ 10−6M), while the other compounds exhibited IC50 values of ≈ 5·10−10 M and IC100 ≈ 5·10−9 M. The findings indicate that the inhibitory substances employed in this study may be used pharmacologically to investigate the role of serine/threonine PPases in RINm5F cell insulin secretion, a process that is likely to be regulated to a major extent by protein ...
A blister is a soft area of skin filled with a clear fluid. Blisters may form in response to an irritant. Frequently, the blister is caused from friction, such as a coarse fabric rubbing repeatedly against a persons skin. In other cases, blisters form in response to a chemical or allergic irritant, which is known as contact dermatitis. Some oral and topical drugs may cause blisters to appear. Blisters can also be symptomatic of bacterial or viral skin infections, such as cold sores, chicken pox, shingles, impetigo or ringworm. Lastly, blisters occur when the skin is exposed to a flame, comes in contact with a hot surface or is overexposed to the sun.. Most blisters do not require medical attention. The most important information to remember is never to pop or break open a blister. A blister acts as a protective covering for damaged skin and helps prevent infection. If a blister does open on its own, be sure to leave the covering in place to support further healing. Simply wash the area gently ...
CS1 maint: Multiple names: authors list (link) Lewis, Robert Alan (1998). "Cantharidin; Cantharidin poisoning". Lewis' ... Karras, DJ; Farrell SE, Harrigan RA, Henretig FM, Gealt L (September 14, 1996). "Poisoning from 'Spanish fly' (cantharidin)". ...
Cantharidin, a poisonous chemical that causes blistering of the skin, is used medically to remove warts and is collected for ... Blister beetles are beetles of the family Meloidae, so called for their defensive secretion of a blistering agent, cantharidin ... In semiarid areas of the western United States, modern harvesting techniques may contribute to cantharidin content in harvested ... University of Colorado Extension Blister Beetles in Forage Crops Blister Beetle Intoxication: Cantharidin Poisoning meloidae. ...
They contain the blister agent cantharidin. Powdered centipede (wu gong) is believed under TCM to treat tetanus, seizures, ...
Studies have found cantharidin to be an effective and safe treatment for removing molluscum contagiosum.[23] This medication is ... "Cantharidin: a comprehensive review of the clinical literature". Dermatology Online Journal (Review). 20 (6). PMID 24945640 ...
Cantharidin toxicity in an animal may be called cantharidiasis. The cantharidin content of one striped blister beetle has been ... 1990). Systemic retention of ingested cantharidin by frogs. Chemoecology 1(2), 57-62. DiFonzo, C. Cantharidin content and ... The toxic dose of cantharidin in horses is about one milligram per kilogram body weight, and the ingestion of 30 to 50 beetles ... Like other blister beetles, it contains cantharidin, a toxic terpenoid. This compound is a vesicant that causes the blistering ...
Cantharidin is used to treat warts that are resistant to other treatment, and although not well-researched it is sufficiently ... Cantharidin is toxic to vertebrates, the aposematic colouration of the beetles being a clear warning. Symptoms of poisoning ... In the late 1700s the Marquis de Sade was charged with poisoning of participants in an orgy by the use of cantharidin. ... Most blister beetle species are protected by cantharidin. Spanish Fly or Lytta vesicatoria also belongs to the Meloidae family ...
The synthesis of cantharidin]. Justus Liebig's Annalen der Chemie. 551: 1. doi:10.1002/jlac.19425510102. Binkley, R. W.; Goewey ...
10 mg of cantharidin can kill a human. This is the origin of the English idiom "your goose is cooked."[citation needed] This ... The poison, cantharidin, is held within the tissue of the fowl resulting in poisoning of those that eat the cooked goose. ...
Sánchez-Barbudo, I. S.; Camarero, P.; García-Montijano, M.; Mateo, R. (2012). "Possible cantharidin poisoning of a great ... Cantharidin can kill a great bustard if many beetles are ingested.[19] Self-medication could have evolved in great bustards as ... Male great bustards may use the highly toxic cantharidin taken from blister beetles of the genus Meloe to clean their intestine ...
Great bustards eat blister beetles of the genus Meloe to decrease parasite load in the digestive system; cantharidin, the toxic ... Sánchez-Barbudo, I. S.; Camarero, P.; García-Montijano, M.; Mateo, R. (2012). "Possible cantharidin poisoning of a great ...
Sweating was also induced using blisters of cantharidin and diaphoretic. Heroic medicine became less favored with the rise of ... He was bled repeatedly and given Mercury(I) chloride (calomel) and several blisters of cantharidin to induce sweating. ...
It is the hydrolysis product of the acid anhydride cantharidin. https://www.scbt.com/scbt/product/cantharidic-acid-28874-45-5. ...
This is primarily due to a poisonous chemical called cantharidin. Cantharidin is one of the most widely known natural products ... Ghoneim, Karem S.) Cantharidin is a poisonous substance which can prove fatal to humans if ingested. The lethal dose for humans ... The brightness of the spots is due to the cantharidin toxins the beetle carries; this coloration is known as aposematism, and ... "A synthetic cantharidin analog for the enhancement of doxorubicin suppression of stem cell-derived aggressive sarcoma." ...
DiFonzo, C. Cantharidin content and lethal dose of common Michigan blister beetles. Field Crops Entomology, Michigan State ... As do other blister beetles, these produce cantharidin, a toxic terpenoid which can kill animals such as horses if they ingest ...
Dauben, W. G.; Kessel, C. R.; Takemura, K. H. (1980). "Simple, efficient total synthesis of cantharidin via a high-pressure ...
Adults contain the toxic cantharidin in their corporal fluids as a defensive mechanism; several species show brilliant and ...
A fatality from cantharidin poisoning has been reported, where dried beetles had been used as an abortifacient. Nakatani, T.; ... Konishi, T.; Miyahara, K.; Noda, N. (2004). "Three Novel Cantharidin-Related Compounds from the Chinese Blister Beetle, ...
... this contains cantharidin, a poisonous chemical causing blistering of the skin and painful swelling. Members of this genus are ...
Blister beetles secrete an irritant called cantharidin, a vesicant that can get onto humans if they touch the beetles. The term ... After skin comes in contact with cantharidin, local irritation begins within a few hours. (This is in contrast to Paederus ... On skin contact with cantharidin-containing blister beetles, local tissue irritation occurs after a few hours. This results ...
Sierra, J.R.; Woggon W.-D.; Schmid, H. (1976). "Transfer of cantharidin (1) during copulation from the adult male to the female ... Karras, David J.; Farrell, S.E.; Harrigan, R.A.; Henretig, F.M.; Gealt, L. (1996). "Poisoning from "Spanish fly" (cantharidin ...
Cantharidin, the blister-causing oil found in several families of beetles, was accepted by the FDA in 2004 as treatment for ... Recent studies in cell culture and animal models have demonstrated powerful tumor fighting properties of Cantharidin. Many ...
Cantharidin, found naturally in the bodies of many members of the beetle family Meloidae, causes dermal blistering. It is used ...
Bravo, C.; Mas-Peinado, P.; Bautista, L.M.; Blanco, G.; Alonso, J.C.; García-París, M. (2017). "Cantharidin is conserved across ...
It was probably a variation of arsenic or cantharidin powder (made from blister beetles)[citation needed]. The use of this ...
Cantharidin and Meloids: a review of classical history, biosynthesis, and function Archived September 3, 2005, at the Wayback ... some naturally occurring substances such as cantharidin are also blister-producing agents (vesicants). Furanocoumarin, another ...
He made contributions in the field of food chemistry and in his research of cantharidin, dinitrocresol, chrysin and resorcinol ...
Drug: Cantharidin 0.7% Subjects in this arm will receive cantharidin at all visits. At the first visit, up to 2 lesions can ... Drug: cantharidins vehicle Cantharidins vehicle is composed of: Hydroxypropylcellulose, Acetone, and Collodion Flexible. The ... Cantharidin is a topical medicine which is applied at the clinic visit. It is well tolerated by the majority of children. ... All other visits will have up to 20 lesions with application of the cantharidin. During every visit, lesions will be counted ...
What is cantharidin wart treatment? Cantharidin. Your doctor "paints" cantharidin on your wart and covers it with a bandage. ... The cantharidin causes the skin under the wart to blister, lifting the wart off the skin. When the blister dries, the wart ... Cantharidin: Your doctor "paints" cantharidin on your wart and covers it with a bandage. This is generally painless. The ... My 3yr old had 4 of her molluscum lesions treated with Cantharidin at the derm. Today. Anything I can do to help relieve her ...
Studies have found cantharidin to be an effective and safe treatment for removing molluscum contagiosum.[23] This medication is ... "Cantharidin: a comprehensive review of the clinical literature". Dermatology Online Journal (Review). 20 (6). PMID 24945640 ...
Cantharidin. Cantharidin is a chemovesicant that is highly effective in treating molluscum contagiosum; however, this agent has ... Cantharidin crystals and diluent can be purchased in the United States, and many dermatologists continue to use it. Cantharidin ... Cantharidin: Several studies report that cantharidin, a chemovesicant that has been used in combination with imiquimod, is ... Cantharidin, [32, 41] silver nitrate, [42] trichloroacetic acid, and phenol also are options. Children may tolerate therapy ...
Topical therapy involves the use of creams like Cantharidin, Tretinoin and Imiquimod for treating molluscum contagiosum. ...
Putting a chemical on the bumps, like cantharidin or potassium hydroxide.. *Using medicines (liquids or creams), such as those ...
Other options for topical therapy include iodine and salicylic acid, potassium hydroxide, tretinoin, cantharidin (a blistering ...
Molluscum contagiosum is a common viral skin infection. For most children, the rash isnt a big deal and goes away on its own over time.
cantharidin synonyms, cantharidin pronunciation, cantharidin translation, English dictionary definition of cantharidin. n. A ... Cantharidin - definition of cantharidin by The Free Dictionary https://www.thefreedictionary.com/cantharidin ... cantharidin. Also found in: Medical, Encyclopedia, Wikipedia. can·thar·i·din. (kăn-thăr′ĭ-dĭn). n.. A toxic compound, C10H12O4 ... cantharidin. (ˌkænˈθærɪdɪn) n. the compound C10H12O4, which is the active ingredient in cantharides and is secreted by many ...
If you have an allergy to cantharidin or any other part of this drug. ...
Would love to hear from members who have used cantharidin (blistering agent produced by a beetle, yes, a beetle) as a treatment ... They places where cantharidin was applied are still red, the molluscum is visible inside there, but I guess it will dry... I am ... Canthacur solution (0.7%Cantharidin) Yes we used this with 100% success. Our 3yr old daughter had hundreds of bubbles all over ... I have had 1 treatment with Cantharidin and it caused only minor discomfort. My derm told me that you should shower as soon as ...
Testing Status of Cantharidin 14049. CASRN: 56-25-7. Formula: C10H12O4. Known Uses. Agricultural Chemical Drug / Therapeutic ...
... marketers of cantharidin failed to produce sufficient efficacy data, resulting in the FDA revision of approval of cantharidin. ... Today, topcial cantharidin products do not necessarily demonstrate any particular better effectiveness at treating topical skin ... Available synthetically since the 1950s, topical applications of cantharidin have been used predominantly as a treatment for ... the male blister beetle secretes and presents the cantharidin to a female beetle as a copulatory gift during mating. Afterwards ...
Cantharidin Application in Molluscum Patients (CAMP-2). The safety and scientific validity of this study is the responsibility ... Have been treated within 14 days with a product that contains cantharidin (topical or homeopathic preparations) for any reason ... Have had any previous treatment of molluscum including the use of cantharidin, antivirals, retinoids, curettage or freezing of ... Cantharidin] in Subjects (2 Years and Older) With Molluscum Contagiosum. ...
Cantharidin is a topical vesicant that causes intraepidermal acantholysis with clinical application that includes the removal ... Conclusion: Topical cantharidin is a safe and effective treatment for warts, molluscum contagiosum, and callus removal, with ... The majority of studies show that cantharidin is an effective and safe treatment for removal of warts and MC. Several studies ... Background: Cantharidin is a topical vesicant that causes intraepidermal acantholysis with clinical application that includes ...
... and LC50 of cantharidin when compared with the control group. Furthermore, the increase in concentration of cantharidin had a ... Cantharidin-induced Skin Blister for Testing Anti-inflammatory Effects of Macrolides. The purpose of this study is to ... Cantharidin, a natural toxin produced by meloid beetles, is a biopesticide with a reported toxicity to some insect pests ... Efficacy of Cantharidin in Molluscum Contagiosum. The University of North Carolina Department of Dermatology is conducting a ...
65 Pages Report] Check for Discount on cantharidin Global Market and Forecast Research report by ChemReport. DescriptionWe ... The price of cantharidin in 2016 Major end users of cantharidin Potential users of cantharidin The main trading companies of ... cantharidin Global Market and Forecast Research Table of Contents Part 1: General Information of cantharidin Chapter 1: ... 2.2 Construction of Industry Chain of cantharidin Chapter 3: End User of cantharidin List of Tables Manufacturers and ...
Cantharidin*Carbo Animalis*Charcoal Activated*Clematis Erecta*Echinacea Angustifolia*Hahnemanns Causticum*Hydrastis Canadensis ... Liquid; Oral; Astragalus Menziesii 6 x; Baptisia Tinctoria 3 x; Cantharidin 12 x; Carbo Animalis 12 x; Charcoal Activated 12 x ...
cantharidin. CA. cantharidic acid. ETA. endothall. NE. norepinephrine. KHS. Krebs-Henseleit solution. CB. carbachol. 2D-PAGE. ... Cantharidin Enhances Norepinephrine-Induced Vasoconstriction in an Endothelium-Dependent Fashion. Jörg Knapp, Peter Bokník, ... Cantharidin Enhances Norepinephrine-Induced Vasoconstriction in an Endothelium-Dependent Fashion. Jörg Knapp, Peter Bokník, ... Cantharidin Enhances Norepinephrine-Induced Vasoconstriction in an Endothelium-Dependent Fashion. Jörg Knapp, Peter Bokník, ...
Cantharidin-induced mitotic arrest is associated with the formation of aberrant mitotic spindles and lagging chromosomes ... Cantharidin-induced mitotic arrest is associated with the formation of aberrant mitotic spindles and lagging chromosomes ... Cantharidin-induced mitotic arrest is associated with the formation of aberrant mitotic spindles and lagging chromosomes ... Cantharidin-induced mitotic arrest is associated with the formation of aberrant mitotic spindles and lagging chromosomes ...
Cantharidin inhibits PPP family phosphatases and cell proliferation. A, effect of cantharidin (inset) on the divalent cation- ... A, cantharidin dose-response. Logarithmically growing A549 cells were treated with cantharidin at the concentrations indicated ... Cantharidin Treatment Induces Abnormal Mitotic Spindle Formation. To explore mechanisms associated with cantharidin-induced G2- ... Therefore, additional cantharidin-sensitive PPases are likely to also contribute to the cytotoxic actions of cantharidin. ...
... , Youssef Al Qahtani, Rishi Kr Bharti, Bothaina Ghazali, ... Cantharidin production in a blister beetle. Experientia, 1993; 49: 171-174. *Tagwireyi D, Ball D, Loga P, et al. Cantharidin ... Cantharidin, Hematemesis, toxic, Acantholysis, Meloidae.. Introduction. Cantharidin is a toxic substance secreted by beetles ( ... Cantharidin Poisoning in a Child with Hematemesis: A Case Report.. Youssef Al Qahtani1*, Rishi Kr Bharti2, Bothaina Ghazali3, ...
... , Yisheng Lin, Yanhao Lia, Zhenpeng ... cantharidin also has strong toxicity, so rational application of cantharidin and strict control of its dose has become the ... Cantharidin content determination and its inhibitory effect on human hepatoma HepG2 cells.. Yisheng Lin1,2, Yanhao Lia1*, ... and flow cytometry was used to detect the effects of cantharidin on cell cycle arrest and apoptosis of HepG2 cells. Cantharidin ...
Find out information about Cantharidin. C10H12O4 Colorless crystals that melt at 218°C; slightly soluble in acetone, chloroform ... Cantharidin. Also found in: Dictionary, Medical, Wikipedia. cantharidin. [kan′thar·ə·dən] (organic chemistry) C10H12O4 ... Dermatitis caused by cantharidin is generally less symptomatic than that caused by pederin because cantharidin blisters do not ... Cantharidin , Article about Cantharidin by The Free Dictionary https://encyclopedia2.thefreedictionary.com/Cantharidin ...
  • [ 27 ] One group was treated with curettage, a second with cantharidin, a third with a combination of salicylic acid and lactic acid, and a fourth with imiquimod. (medscape.com)
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