A toxic compound, isolated from the Spanish fly or blistering beetle (Lytta (Cantharis) vesicatoria) and other insects. It is a potent and specific inhibitor of protein phosphatases 1 (PP1) and 2A (PP2A). This compound can produce severe skin inflammation, and is extremely toxic if ingested orally.
INSECTS of the order Coleoptera, containing over 350,000 species in 150 families. They possess hard bodies and their mouthparts are adapted for chewing.
A specific inhibitor of phosphoserine/threonine protein phosphatase 1 and 2a. It is also a potent tumor promoter. (Thromb Res 1992;67(4):345-54 & Cancer Res 1993;53(2):239-41)
A group of enzymes removing the SERINE- or THREONINE-bound phosphate groups from a wide range of phosphoproteins, including a number of enzymes which have been phosphorylated under the action of a kinase. (Enzyme Nomenclature, 1992)
Sexual union of a male and a female in non-human species.
Most abundant proteins in COBRA venom; basic polypeptides of 57 to 62 amino acids with four disulfide bonds and a molecular weight of less than 7000; causes skeletal and cardiac muscle contraction, interferes with neuromuscular and ganglionic transmission, depolarizes nerve, muscle and blood cell membranes, thus causing hemolysis.
A common, benign, usually self-limited viral infection of the skin and occasionally the conjunctivae by a poxvirus (MOLLUSCUM CONTAGIOSUM VIRUS). (Dorland, 27th ed)
A species of MOLLUSCIPOXVIRUS causing skin lesions in humans. It is transmitted by direct contact or from non-living reservoirs (fomites), such as books or clothing.
A family of double-stranded DNA viruses infecting mammals (including humans), birds and insects. There are two subfamilies: CHORDOPOXVIRINAE, poxviruses of vertebrates, and ENTOMOPOXVIRINAE, poxviruses of insects.
A CC-type chemokine with specificity for CCR10 RECEPTORS. It is constitutively expressed in the skin and may play a role in T-CELL trafficking during cutaneous INFLAMMATION.
Separation of the prickle cells of the stratum spinosum of the epidermis, resulting in atrophy of the prickle cell layer. It is seen in diseases such as pemphigus vulgaris (see PEMPHIGUS) and DARIER DISEASE.
Benign epidermal proliferations or tumors; some are viral in origin.
Severe irritant and vesicant of skin, eyes, and lungs. It may cause blindness and lethal lung edema and was formerly used as a war gas. The substance has been proposed as a cytostatic and for treatment of psoriasis. It has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP-85-002, 1985) (Merck, 11th ed).
Group of chronic blistering diseases characterized histologically by ACANTHOLYSIS and blister formation within the EPIDERMIS.
Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic.
Unstriated and unstriped muscle, one of the muscles of the internal organs, blood vessels, hair follicles, etc. Contractile elements are elongated, usually spindle-shaped cells with centrally located nuclei. Smooth muscle fibers are bound together into sheets or bundles by reticular fibers and frequently elastic nets are also abundant. (From Stedman, 25th ed)
The nonstriated involuntary muscle tissue of blood vessels.
A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
The relationship between the dose of an administered drug and the response of the organism to the drug.
Single pavement layer of cells which line the luminal surface of the entire vascular system and regulate the transport of macromolecules and blood components.
The physiological widening of BLOOD VESSELS by relaxing the underlying VASCULAR SMOOTH MUSCLE.
Visible accumulations of fluid within or beneath the epidermis.
Material used for wrapping or binding any part of the body.
Messages between computer users via COMPUTER COMMUNICATION NETWORKS. This feature duplicates most of the features of paper mail, such as forwarding, multiple copies, and attachments of images and other file types, but with a speed advantage. The term also refers to an individual message sent in this way.
A microtubule structure that forms during CELL DIVISION. It consists of two SPINDLE POLES, and sets of MICROTUBULES that may include the astral microtubules, the polar microtubules, and the kinetochore microtubules.
A type of CELL NUCLEUS division by means of which the two daughter nuclei normally receive identical complements of the number of CHROMOSOMES of the somatic cells of the species.
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
The orderly segregation of CHROMOSOMES during MEIOSIS or MITOSIS.
The medical science concerned with the prevention, diagnosis, and treatment of diseases in animals.
Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.

The protein phosphatase inhibitor cantharidin induces head and foot formation in buds of Cassiopea andromeda (Rhizostomae, Scyphozoa). (1/89)

The polyps of Cassiopea andromeda produce spindle shaped, freely swimming buds which do not develop a head (a mouth opening surrounded by tentacles) and a foot (a sticky plate at the opposite end) until settlement to a suited substrate. The buds, therewith, look very similar to the planula larvae produced in sexual reproduction. With respect to both, buds and planulae, several peptides and the phorbolester TPA have been found to induce the transformation into a polyp. Here it is shown that cantharidin, a serine/threonine protein phosphatase inhibitor, induces head and foot formation in buds very efficiently in a 30 min treatment, the shortest yet known efficient treatment. Some resultant polyps show malformations which indicate that a bud is ordinary polyp tissue in which preparatory steps of head and foot formation mutually block each other from proceeding. Various compounds related to the transfer of methyl groups have been shown to affect head and foot formation in larvae of the hydrozoon Hydractinia echinata. These compounds including methionine, homocysteine, trigonelline, nicotinic acid and cycloleucine are shown to also interfere with the initiation of the processes which finally lead to head and foot formation in buds of Cassiopea andromeda.  (+info)

The protein phosphatase inhibitor cantharidin alters vascular endothelial cell permeability. (2/89)

In this study, we characterized the effects of the protein phosphatases type 1 (PP 1) and type 2A (PP 2A) inhibitor cantharidin in endothelial cells. We identified catalytic subunits of PP 1alpha, PP 2Aalpha, and PP 2Abeta immunologically in bovine aortic endothelial cells. Moreover, we detected mRNAs coding for catalytic subunits of PP 1alpha, PP 1beta, and PP 2Aalpha by hybridization with specific DNA probes in total RNA from these cells. Okadaic acid and cantharidin inhibited the activities of catalytic subunits of PP 1 (okadaic acid, 0.01-1 microM; cantharidin, 1-100 microM) and PP 2A (okadaic acid, 0.1 nM to 1 microM; cantharidin, 0.1-100 microM) separated by column chromatography in a concentration-dependent manner. Moreover, cantharidin (1 microM to 1 mM) increased the phosphorylation state of endothelial proteins including the regulatory light chains of myosin without affecting cytosolic calcium concentrations. Cantharidin (5-100 microM) increased the permeability of cultured endothelial cells in a time- and concentration-dependent manner. We suggest that inhibition of PP 1 and PP 2A activities by cantharidin increases endothelial permeability by enhancing the phosphorylation state of endothelial regulatory proteins. Thus, cantharidin might be a useful tool to study the function of protein phosphatases in endothelial barrier function.  (+info)

Penetration of moxifloxacin into peripheral compartments in humans. (3/89)

To characterize the penetration of moxifloxacin (BAY 12-8039) into peripheral target sites, the present study aimed at measuring unbound moxifloxacin concentrations in the interstitial space fluid by means of microdialysis, an innovative clinical sampling technique. In addition, moxifloxacin concentrations were measured in cantharides-induced skin blisters, saliva, and capillary plasma and compared to total- and free-drug concentrations in venous plasma. For this purpose, 12 healthy volunteers received moxifloxacin in an open randomized crossover fashion either as a single oral dose of 400 mg or as a single intravenous infusion of 400 mg over 60 min. An almost-complete equilibration of the free unbound plasma fraction of moxifloxacin with the interstitial space fluid was observed, with mean area under the concentration-time curve (AUC)(interstitial fluid)/AUC(total-plasma) ratios ranging from 0.38 to 0.55 and mean AUC(interstitial fluid)/AUC(free-plasma) ratios ranging from 0.81 to 0.86. The skin blister concentration/plasma concentration ratio reached values above 1.5 after 24 h, indicating a preferential penetration of moxifloxacin into inflamed lesions. The moxifloxacin concentrations in saliva and capillary blood were similar to the corresponding levels in plasma. Our data show that moxifloxacin concentrations attained in the interstitial space fluid in humans and in skin blister fluid following single doses of 400 mg exceed the values for the MIC at which 90% of isolates are inhibited for most clinically relevant bacterial strains, notably including penicillin-resistant Streptococcus pneumoniae. These findings support the use of moxifloxacin for the treatment of soft tissue and respiratory tract infections in humans.  (+info)

A study to determine the pharmacokinetics and inflammatory fluid penetration of gatifloxacin following a single oral dose. (4/89)

A single 400 mg oral dose of gatifloxacin was given to each of nine healthy male volunteers and the concentrations of the drug in plasma, cantharidine-induced inflammatory fluid and urine were measured over the following 24 h. The mean peak concentration in plasma of 4. 1 mg/L was attained at a mean time of 1.8 h post dose. The mean peak concentration in inflammatory fluid was 3.6 mg/L and was attained at a mean time of 4.2 h post dose. The mean plasma elimination half-life of gatifloxacin was 6.8 h and that in inflammatory fluid was 7.2 h. The mean penetration into the inflammatory fluid was 117%. Recovery of drug from urine during the first 24 h post dose was 65% of that administered. Our data suggest that gatifloxacin dosed at 400 mg od should be adequate to treat systemic infections caused by most bacterial species.  (+info)

Phosphatase inhibitor cantharidin blocks adenosine A(1) receptor anti-adrenergic effect in rat cardiac myocytes. (5/89)

Experiments were performed to examine whether the protein phosphatase inhibitor cantharidin blocks the anti-adrenergic effect of adenosine A(1) receptor stimulation. In electrically stimulated adult rat ventricular myocytes loaded with the intracellular calcium concentration ([Ca(2+)](i)) indicator fluo-3, isoproterenol (10 nM) increased systolic [Ca(2+)](i) by 46%, increased twitch amplitude by 56%, and increased total cellular cAMP content by 140%. The adenosine A(1) receptor agonist 2-chloro-N(6)-cyclopentlyadenosine (CCPA) reduced isoproterenol-stimulated [Ca(2+)](i) and contractility by 87 and 80%, respectively, but reduced cAMP content by only 18%. Cantharidin had no effects on myocyte [Ca(2+)](i), contractility, or cAMP in the absence or presence of isoproterenol but blocked the effects of CCPA on [Ca(2+)](i) and contractility by approximately 44%. Cantharidin had no effect on CCPA attenuation of isoproterenol-induced increases in cAMP. Pretreatment with CCPA also reduced the increase in contractile parameters produced by the direct cAMP-dependent protein kinase A (PKA) activator 8-bromocAMP. These results suggest that activation of protein phosphatases mediate, in part, the anti-adrenergic effect of adenosine A(1) receptor activation in ventricular myocardium.  (+info)

Hamster pancreatic beta cell lines with altered sensitivity towards apoptotic signalling by phosphatase inhibitors. (6/89)

Specific inhibitors of serine/threonine phosphatases like okadaic acid can induce apoptotic cell death in the pancreatic beta cell line HIT. Cultivation in stepwise increased concentrations of okadaic acid enabled the isolation of HIT100R cells which proliferate at 100 nM okadaic acid (8 - 10 times the initially lethal concentration). These two cell lines were used to characterize the events triggered by okadaic acid that led to apoptosis. Biochemical markers, e.g. cytochrome c release from mitochondria and increase of caspase-3-like activity, revealed that induction of apoptosis by 100 nM okadaic acid in parental HIT cells started with the release of cytochrome c. In HIT100R cells 500 nM okadaic acid were necessary to induce alterations comparable to those observed with 100 nM okadaic acid in non-resistant HIT cells. In contrast to okadaic acid, the potency of the structurally different phosphatase inhibitor cantharidic acid to induce cytochrome c release, increase of caspase-3-like activity and DNA fragmentation was comparable in HIT and HIT100R cells. Thus, no cross-resistance between these phosphatase inhibitors seemed to exist. Phosphatase activity in extracts from HIT and HIT100R cells did not differ in its total amount or in its sensitivity for okadaic acid. Since higher concentrations of okadaic acid were needed to induce apoptosis in HIT100R cells, a compromised intracellular accumulation of the toxin appeared likely. Functional and structural analysis revealed that this was achieved by the development of the multidrug resistance phenotype in HIT100R cells. The underlying mechanism appeared to be the enhanced expression of the pgp1 but not the pgp2 gene.  (+info)

Protein phosphatase inhibitors arrest cell cycle and reduce branching morphogenesis in fetal rat lung cultures. (7/89)

Protein phosphatase 2A (PP2A) is a key signal transduction intermediate in the regulation of cellular proliferation and differentiation in vitro. However, the role of PP2A in the context of a developing organ is unknown. To explore the role of PP2A in the regulation of lung development, we studied the effect of PP2A inhibition on new airway branching, induction of apoptosis, DNA synthesis, and expression of epithelial marker genes in whole organ explant cultures of embryonic (E14) rat lung. Microdissected lung primordia were cultured in medium containing one of either two PP2A inhibitors, okadaic acid (OA, 0-9 nM) or cantharidin (Can, 0-3,600 nM), or with the PP2B inhibitor deltamethrin (Del, 0-10 microM) as a control for a PP2A-specific effect for 48 h. PP2A inhibition with OA and Can significantly inhibited airway branching and overall lung growth. PP2B inhibition with Del did not affect lung growth or new airway development. Histologically, both PP2A- and PP2B-inhibited explants were similar to controls. Increased apoptosis was not the mechanism of decreased lung growth and new airway branching inasmuch as OA-treated explant sections subjected to the terminal deoxynucleotidyltransferase dUTP nick end labeling reaction demonstrated a decrease in apoptosis. However, PP2A inhibition with OA increased DNA content and 5-bromo-2'-deoxyuridine uptake that correlated with a G(2)/M cell cycle arrest. PP2A inhibition also resulted in altered differentiation of the respiratory epithelium as evidenced by decreased mRNA levels of the early epithelial marker surfactant protein C. These findings suggest that inhibition of protein phosphatases with OA and Can halted mesenchymal cell cycle progression and reduced branching morphogenesis in fetal rat lung explant culture.  (+info)

Cantharidin enhances norepinephrine-induced vasoconstriction in an endothelium-dependent fashion. (8/89)

In this study we characterized the effects of the protein phosphatase (PP) type 1 and type 2A inhibitor cantharidin (Cant) and its structural analogs cantharidic acid and endothall on PP activity, force of contraction, and myosin light chain phosphorylation in rat aorta. All compounds inhibited PP activity in homogenates of rat aorta with a rank order of potency of Cant = cantharidic acid > endothall. However, only Cant increased force of contraction and myosin light chain phosphorylation in intact isolated rat aortic rings. Based on these findings, we investigated the effects of Cant on alpha-adrenoceptor-mediated vasoconstriction. Cant (1 and 3 microM) enhanced norepinephrine-induced contraction in endothelium-intact rat aorta. In contrast, Cant did not affect norepinephrine-induced contraction in endothelium-denuded rat aorta. We suggest that inhibition of PP1 and/or PP2A activities by Cant enhances vascular contractility in endothelium-intact rat aorta by increasing the phosphorylation state of endothelial regulatory proteins.  (+info)

Cantharidin side effects - What is cantharidin wart treatment? Cantharidin. Your doctor paints cantharidin on your wart and covers it with a bandage. This is generally painless. The cantharidin causes the skin under the wart to blister, lifting the wart off the skin. When the blister dries, the wart comes off with the blistered skin. You may feel some pain when the skin blisters. When you see your doctor again, he or she will remove the dead skin and may retreat.
Herbal medicine is one of the forms of traditional medical practice. Traditional Chinese medicine (TCM) and traditional Vietnamese medicine (TVM) are well-known for their long-standing tradition of herbal medicine. Secreted by many species of blister beetle, most notably by the Spanish fly (Lytta vesicatoria), cantharidin inhibits protein phosphatases 1 and 2A (PP1, PP2A). Blister beetle has been used in Asian traditional medicine to treat Molluscum contagiosum virus (MCV) infections and associated warts, and is now also used for cancer treatment. A combination of both genomic and postgenomic techniques was used in our studies to identify candidate genes affecting sensitivity or resistance to cantharidin. Cantharidin was not found to be related to multidrug resistance phenotype, suggesting its potential usefulness for the treatment of refractory tumors. Oxidative stress response genes diminish the activity of cantharidin by inducing DNA strand breaks which may be subject to base excision repair and
p,Cantharidin is a natural toxin and an active constituent in a traditional Chinese medicine used to treat tumors. Cantharidin acts as a semi-selective inhibitor of PPP-family ser/thr protein phosphatases. Despite sharing a common catalytic mechanism and marked structural similarity with PP1C, PP2AC and PP5C, human PP4C was found to be insensitive to the inhibitory activity of cantharidin. To explore the molecular basis for this selectivity, we synthesized and tested novel C5/C6-derivatives designed from quantum-based modeling of the interactions revealed in the co-crystal structures of PP5C in complex with cantharidin. Structure-activity relationship studies and analysis of high-resolution (1.25Å) PP5C-inhibitor co-crystal structures reveal close contacts between the inhibitor bridgehead oxygen and both a catalytic metal ion and a non-catalytic phenylalanine residue, the latter of which is substituted by tryptophan in PP4C. Quantum chemistry calculations predicted that steric clashes with the ...
Looking for Cantharidin? Find out information about Cantharidin. C10H12O4 Colorless crystals that melt at 218°C; slightly soluble in acetone, chloroform, alcohol, and water; used in veterinary medicine. Also known as... Explanation of Cantharidin
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TY - JOUR. T1 - Cantharidin-induced cytotoxicity and cyclooxygenase 2 expression in human bladder carcinoma cell line. AU - Huan, Steven Kuan Hua. AU - Lee, Hao Hsien. AU - Liu, Der Zen. AU - Wu, Chien Chih. AU - Wang, Ching Chiung. PY - 2006/6/1. Y1 - 2006/6/1. N2 - Mylabris is used in clinical therapy, but is always accompanied by cystitis. The toxic effects of mylabris on bladder are attributed to its active principle: cantharidin. In the present study, we explored how cantharidin induces cytotoxicity in the bladder. Human bladder carcinoma cell line T 24 cells were used as target cells, and human colon carcinoma HT 29 cells as native cells. Cantharidin exhibited acute cytotoxicity in the T 24 cells, and IC50 was 21.8, 11.2 and 4.6 μM after treatment for 6, 24 and 48 h, respectively. The cytotoxicity of cantharidin was not significantly enhanced when T 24 cells were treated for a longer time. Moreover, PARP proteins and pro-caspase 3, Bcl-2 were significantly inhibited after cantharidin ...
Cantharidin is an organic compound belonging to the terpenoid class. It is a colorless and odorless fatty substance. Its also a burn agent secreted from the legs of the male Spanish Fly beetle - it causes severe blisters and is poisonous in large doses. It has been reported that Cantharidin is a necessary ingredient, functioning like an aphrodisiac for the courting and mating rituals of Spanish Fly and other beetles. The vesicant chemical is initially procured by the male beetles from an exogenous source - mostly by ingestion. After ingestion, the Cantharidin secretion begins in the cephalic gland, which is present exclusively in the head of the males. During their courting rituals, the males present the females with Cantharidin (in the form of an oozing gift). The females of the species become allured, and during the process of mating, the males transfer the majority of the secreted Cantharidin along with spermatozoa. The female beetles use Cantharidin to cover the eggs for defense against ...
Cantharidin is an organic compound belonging to the terpenoid class. It is a colorless and odorless fatty substance. Its also a burn agent secreted from the legs of the male Spanish Fly beetle - it causes severe blisters and is poisonous in large doses. It has been reported that Cantharidin is a necessary ingredient, functioning like an aphrodisiac for the courting and mating rituals of Spanish Fly and other beetles. The vesicant chemical is initially procured by the male beetles from an exogenous source - mostly by ingestion. After ingestion, the Cantharidin secretion begins in the cephalic gland, which is present exclusively in the head of the males. During their courting rituals, the males present the females with Cantharidin (in the form of an oozing gift). The females of the species become allured, and during the process of mating, the males transfer the majority of the secreted Cantharidin along with spermatozoa. The female beetles use Cantharidin to cover the eggs for defense against ...
Topically administered cantharidin induces increased release of MIP-2, MCP-1, KC, IL-6, IL-1b, MPO and neutrophil accumulation in ear tissue. Sixteen hours after cantharidin application, ear swelling is observed, persisiting for the next 7 days.. The activity of test compounds is evaluated by ear weighing (main read-out). Ear tissue and other selected tissues can be stored for subsequent analyses (facultative read-outs). ...
Adults are omnivorous, often feeding on pollen (taking part in flower pollination) or plant exudates; cases of micropredation have also been registered. Most Notoxinae prefer sandy soils for laying eggs. Many species, particularly of Notoxus, are known to be canthariphilous and are attracted to cantharidin. The cantharidin is mostly obtained by males. In some groups, males bear secretory glands that concentrate the cantharidin in special canals or pits at the elytral apices, indicated as apical tubercles. Being highly poisonous, cantharidin is used by Notoxinae as a feeding deterrent against predators or acts as a kairomone for braconid wasps, endoparasites of Notoxus. Females take the cantharidin into their bodies when feeding upon the secretions of the males. Females also pass the cantharidin to the eggs and larvae and it is used for protection by them. ...
Blister beetles produce cantharidin, a poisonous substance comparable to cyanide and strychnine in toxicity. Stored in the insects blood, the compound is stable and remains toxic even in beetle carcasses. Animals may be poisoned by ingesting beetles while grazing or eating harvested silage. Cantharidin can also cause severe skin inflammation and blisters.. Cantharidin is absorbed through the intestine and can cause symptoms such as inflammation, colic, straining, elevated temperature, depression, increased heart rate and respiration, dehydration, sweating, and diarrhea. There is frequent urination during the first 24 hours after ingestion, accompanied by inflammation of the urinary tract. This irritation may also result in secondary infection and bleeding. Taken internally, as little as 10 milligrams can be fatal in humans.. The concentration of cantharidin in adult beetles depends primarily on the sex; males produce the chemical and only pass on small amounts to the females during mating. ...
Blister beetles produce cantharidin, a poisonous substance comparable to cyanide and strychnine in toxicity. Stored in the insects blood, the compound is stable and remains toxic even in beetle carcasses. Animals may be poisoned by ingesting beetles while grazing or eating harvested silage. Cantharidin can also cause severe skin inflammation and blisters.. Cantharidin is absorbed through the intestine and can cause symptoms such as inflammation, colic, straining, elevated temperature, depression, increased heart rate and respiration, dehydration, sweating, and diarrhea. There is frequent urination during the first 24 hours after ingestion, accompanied by inflammation of the urinary tract. This irritation may also result in secondary infection and bleeding. Taken internally, as little as 10 milligrams can be fatal in humans.. The concentration of cantharidin in adult beetles depends primarily on the sex; males produce the chemical and only pass on small amounts to the females during mating. ...
In this study, the specific contribution of polyamine oxidase (PAO), a hydrogen peroxide (H₂O₂)-producing enzyme, to the oxidative burst induced in maize mesocotyl by the phosphatase inhibitor cantharidin was examined. For this purpose, a pharmacological approach was applied using, either in vitro or in vivo, two strong inhibitors of maize PAO (MPAO), N-prenylagmatine (G3) and its structural analogue Ro5, as well as diphenyleneiodonium (DPI), an inhibitor of the phagocyte NAD(P)H oxidase. DPI was shown to be a good MPAO inhibitor in vitro. G3, Ro5, and DPI were very effective in inhibiting in vivo the extracellular accumulation of H₂O₂ that is released by mesocotyl segments upon spermidine supply. G3 and Ro5 did not show any inhibition in vitro of either horseradish peroxidase or barley oxalate oxidase. Moreover, G3 and Ro5 did not inhibit the extracellular accumulation of superoxide radical that is released in vivo upon NADH supply. G3, Ro5, and DPI strongly affected H₂O₂ production ...
Spanish fly doesnt actually come from a fly. It is made from the cantharides beetle, also called the blister beetle, or Cantharis vesicatoria. The name comes from an intense irritant they generate as a defense mechanism. The beetles are collected, killed, dried and powdered, and the result is called Spanish fly.. Cantharides, being a natural inflammatory agent, can burn the mouth and throat and cause abdominal pain, vomiting, diarrhea and kidney damage even in small doses. It also strongly irritates the genito-urinary tract, and sex is one way to calm that itch. The stories regarding medical application of cantharides would be listed as not to be believed, except that they are true. In 1752 a Frenchman was prescribed 2 drams of cantharides for a fever and in the next two months bedded his wife at least 87 times. Another man with a similar prescription knew his wife, as the Bible puts it, 40 times in one night.. As little as one thousandth of an ounce of the active chemical in cantharides is ...
Background: Cantharidin is a topical vesicant that causes intraepidermal acantholysis with clinical application that includes the removal of warts, molluscum contagiosum (MC), calluses, and acquired perforating dermatoses. Objective: To provide a com
This is one beautiful Blister Beetle in the family Meloidae and the colors on your image, the bold black and white beetle, the orange antennae and the ultraviolet purple blossom are stunning. We quickly identified a similar looking Blister Beetle on the Kenya Natural History Guide that is identified as being in the genus Mylabris. The site states: Many blister beetles are so toxic to mammals that ingestion of a few may be enough to kill a horse. It happens occasionally when the beetles get wrapped up into a bale of hay, quite by accident. Birds somehow just know that a beetle with this pattern should never be eaten, and they leave them alone. There are many, many species of Mylabris distributed across Africa, Europe and Asia. Once we had a genus name, we identified the species on Beetles of Africa and confirmed the identification on iSpot. ...
Blister beetle, (family Meloidae), any of approximately 2,500 species of beetles (insect order Coleoptera) that secrete an irritating substance, cantharidin, which is collected mainly from Mylabris and the European species Lytta vesicatoria, commonly called Spanish fly. Cantharidin is used
Bean blister beetle on a plant stem. Blister beetles (family Meloidae) are so called for their defensive secretion of the chemical cantharidin, which causes blistering of the skin. Photographed on Nanao island, Guangdong, China. - Stock Image C019/7962
Blister beetles excrete a toxic blistering agent called cantharidin, which can cause irritation and blistering when it comes in contact with the eyes, skin, mouth, throat, or digestive tract. The irritation and blisters that form can be painful but usually are not life-threatening. Blister beetles are notorious for their ancient use as an aphrodisiac. Not only is such use groundless, it can also be fatal.
A web search did not turn up a more exact identification, but there is this site which has a photo of a close relative Lytta magister http://www.solpugid.com/gallery/Gallery3.htm which also has a red head and legs. I do have some interesting background information on the genus however. A blue-green colored European relative Lytta vesicatoria, is known by the common name Spanish fly: Perhaps the most famous `aphrodisiac of folk lore is `Spanish Fly made from the dried beetle _Cantharis_ (Lytta) _vesicatoria_, which is widely found in areas of southern Europe. The active ingredient of the prepared insect is cantharidin, and the powdered product contains around 0.6 percent of the substance. Sometimes a tincture of cantharidin is made, and the fatal dose is usually reckoned at 1.5 to 3 grams of the powder, or about 200 millilitres of the tincture. I have not given up entirely on the identification. I will be making a trip to the insect museum in Riverside in the near future. Thanks again for the ...
Cantharis Vesicatoria.). Common name.- Spanish Fly.. General Analysis.-. Cantharis acts especially upon the mucous membranes and upon the skin.. Its decidedly most important action is upon the mucous lining of the urinary tract, where it produces conditions ranging all the way from an irritation to a violent destructive inflammation, either of a part or of the whole tract.. The mucous membrane of the digestive tract is also involved in an inflammatory condition.. On the skin the irritative action of Cantharis results in an erysipelatous form of inflammation, and vesicular conditions in general.. The chief characteristic of this drug is its constant urging to urinate, scanty discharge, and violent cutting, burning pains before, during, and after the discharge.. Characteristic symptoms.. Mind.- (Cantharis). Anxious restlessness, ending in rage.. Constant, complete, furious, almost frenzied delirium. (Bell., Hyos., Oenan., Stram.). Insolent and contradictory mood. (Bry., Nux v.). Head.- ...
When you kill a blister beetle by crushing it against your skin, a poison in the beetles body causes a painful blister. The blisters are only the beginning of the many problems that these insects cause. In this article, youll learn about blister beetle control.
References:. Arnett, R.H., Jr., M.C. Thomas, P.E. Skelley & J.H. Frank. (editors). 2002. American Beetles, Volume II: Polyphaga: Scarabaeoidea through Curculionoidea. CRC Press. 861 pp.. Borror, D.J. 1960. Dictionary of Word Roots and Combining Forms. National Press Books, Palo Alto. 134 pp.. Brown, W.D. 1990. Size-assortative mating in the blister beetle Lytta magister (Coleoptera: Meloidae) is due to male and female preference for larger mates. Animal Behaviour 40: 901-909. Selander, R.B. 1960. Bionomics, Systematics, and Phylogeny of Lytta, a Genus of Blister Beetles (Coleoptera: Meloidae). Illinois Biological Monographs: Number 28. 295 pp.. White. R.E. 1983. A Field Guide to the Beetles of North America. Houghton Mifflin Company, Boston. 368 pp.. ...
Blister beetles are aptly named, for when they are disturbed they emit a yellow, oily, defensive secretion (cantharidin) from their joints which usually causes blisters when it comes in contact with skin. This toxin deters many potential predators and is especially effective against ants. According to naturalist/forester/writer Ginny Barlow, as little as 100 milligrams is…
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An update on my post of July 4…. Weve had 4 invasions of blister beetles this summer. 2 were major, 100s or 1000s of bugs, in repeated waves, lasted for several days - turned parts of the garden to sticks within a few hours; and 2 invasions were minor (maybe fewer than 100 beetles) and quickly wiped out. Ive now seen 3 species of blister beetles: (a) one thats mostly grey with a little black, and these come in herds; (b) one thats black with small orange triangles on the abdomen behind the wing covers, and these are solitary - just a few at a time; and (c) one thats yellow & brown striped on its back; these were the most common in Missouri when I lived there; Ive seen only a few of them late in the summer here in Arkansas.. …about the Pyrethrins: The brand is Bonide concentrate, 1% pyrethrin. We ordered this thru the local Ace Hardware - $20.99 for 8 ounces - and now the local health food store carries it in their garden section. Since then, Ive Googled Bonide pyrethrin; found ...
An update on my post of July 4…. Weve had 4 invasions of blister beetles this summer. 2 were major, 100s or 1000s of bugs, in repeated waves, lasted for several days - turned parts of the garden to sticks within a few hours; and 2 invasions were minor (maybe fewer than 100 beetles) and quickly wiped out. Ive now seen 3 species of blister beetles: (a) one thats mostly grey with a little black, and these come in herds; (b) one thats black with small orange triangles on the abdomen behind the wing covers, and these are solitary - just a few at a time; and (c) one thats yellow & brown striped on its back; these were the most common in Missouri when I lived there; Ive seen only a few of them late in the summer here in Arkansas.. …about the Pyrethrins: The brand is Bonide concentrate, 1% pyrethrin. We ordered this thru the local Ace Hardware - $20.99 for 8 ounces - and now the local health food store carries it in their garden section. Since then, Ive Googled Bonide pyrethrin; found ...
Recently I have had several samples of blister beetles brought into the office. They have been on a rampage in a few tomato patches recently. Blister beetles are about three quarters of an inch to an inch and a quarter long. They have narrow bodies, broad heads, and antennae that are about one-third the length of the entire body. There are three types or colors in Kentucky, jet black, striped with orange and black, and margined (which were brought in the office) that are black and have a thin gray stripe around the wing covers.
Recently I have had several samples of blister beetles brought into the office. They have been on a rampage in a few tomato patches recently. Blister beetles are about three quarters of an inch to an inch and a quarter long. They have narrow bodies, broad heads, and antennae that are about one-third the length of the entire body. There are three types or colors in Kentucky, jet black, striped with orange and black, and margined (which were brought in the office) that are black and have a thin gray stripe around the wing covers.
BLISTER BEETLE BIOLOGY Blister beetles are commonly found in the yard and garden. Theyre a unique insect because they cause all kinds of reactions on peop
Unele studii au prezentat eficacitatea sa human papillomavirus genital warts treatment în cazul leziunilor cutanate, în special în cazul verucilor plane. Genital warts: They appear as flat lesions, small cauliflower-like bumps or tiny stem-like protrusions.
View Notes - Chemical Basis of Life F10 from BIOL 121 at University of Evansville. 3Biol 121 Anatomy and Physiology I Chemical Basis of Life I. Matter and Energy A. Matter - anything that occupies
The Canadian Food Inspection Agency is investigating the presence of Iron Cross Blister Beetles in imported leafy vegetables. Consumer complaints have alerted the agency to this issue. No illnesses or injuries have been reported at this time. The Iron Cross Blister beetle releases a chemical called cantharidin that can cause blisters on the skin. It has a bright red head and bright yellow markings on the wings, separated by a glass cross. This beetle should be treated with caution. Public health officials are waring consumers to wash and carefully look over their leafy vegetables throughly before serving and eating them. The beetle should be removed without touching it or crushing it. If you do find one, contact your local CFIA office. The beetle was found in pre-packaged salads … [Read more...] ...
Normally these beetles emerge in large numbers in mid to late spring and move together in bands crawling or running across the ground. They feed on succulent leaves and flower petals. The larva stage is subterranean and likely is parasitic in nests of ground-nesting bees.. Iron Cross Beetles conspicuous coloration is related to the fact that they carry cantharidin toxins that can interfer with the vertibrate nervous system - i.e. it is an aposemtic warning. In case you were wondering, you should not eat these insects. ...
Thank you for sharing this Molecular Cancer Therapeutics article.. NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.. ...
The family Oedemeridae includes pollen-feeding beetles that are commonly called false blister beetles in English. The Japanese name kamikiri-modoki means false longhorn (kamikiri). I found this specimen on a vending machine at night (near Inunaki Dam in Fukuoka).. ...
Although markings vary greatly depending on the species, blister beetles are easily identified by their physique: the middle section of the body is noticeably smaller than the head or abdomen. The majority of these pests are well under an inch long.. Life Cycle: Adults lay eggs beneath the soil, where the newly hatched grubs feed on grasshopper eggs. The grubs remain underground in a dormant state for up to 2 years, then become active, pupate, and emerge as plant- feeding adults in late spring or early Summer.. ...
University of Wisconsin - Madison Division of Extension Releases Blister Beetle Fact Sheet (Madison) University of Wisconsin - Madison Division of Extensio
A story of blood, love, and family… Learn about one of the biggest and fanciest blister beetles anywhere. This species goes by the scientific name of Lytta magister but has also been called the
Alex the horse and the blister beetles | Book 477426 by: Tyra easter theme: Open Theme format: 11x8.5 - Hardcover w/Glossy Laminate - Color - Photo Book
Blister Beetles are the source for the Venom that Lara Croft needs for Crafting Lure Arrows and Poison Grenades. It is highly toxic and kills her Enemies on contact. ...
The present study was undertaken to determine whether the two ubiquitously expressed Ca(2+)-independent phosphatases PP1 and PP2A regulate Ca(2+)-activated Cl(-) currents (I(Cl(Ca))) elicited by 500 nM [Ca(2+)](i) in rabbit pulmonary artery (PA) myocytes dialyzed with or without 3 mM ATP. Reverse transcription-PCR experiments revealed the expression of PP1alpha, PP1beta/delta, PP1gamma, PP2Aalpha, PP2Abeta, PP2Balpha (calcineurin (CaN) Aalpha), and PP2Bbeta (CaN Abeta) but not PP2Bgamma (CaN Agamma) in rabbit PA. Western blot and immunofluorescence experiments confirmed the presence of all three PP1 isoforms and PP2A. Intracellular dialysis with a peptide inhibitor of calcineurin (CaN-AIP); the non-selective PP1/PP2A inhibitors okadaic acid (0.5, 10, or 30 nM), calyculin A (10 nM), or cantharidin (100 nM); and the selective PP1 inhibitor NIPP-1 (100 pM) potently antagonized the recovery of I(Cl(Ca)) in cells dialyzed with no ATP, whereas the PP2A-selective antagonist fostriecin (30 or 150 nM) was
Chattopadhyay D, Swingle MR, Salter EA, Wood E, DArcy B, Zivanov C, Abney K, Musiyenko A, Rusin SF, Kettenbach A, et al. Crystal structures and mutagenesis of PPP-family ser/thr protein phosphatases elucidate the selectivity of cantharidin and novel norcantharidin-based inhibitors of PP5C. Biochemical Pharmacology. 2016 ;109:14-26. ...
Chattopadhyay D, Swingle MR, Salter EA, Wood E, DArcy B, Zivanov C, Abney K, Musiyenko A, Rusin SF, Kettenbach A, et al. Crystal structures and mutagenesis of PPP-family ser/thr protein phosphatases elucidate the selectivity of cantharidin and novel norcantharidin-based inhibitors of PP5C. Biochemical Pharmacology. 2016 ;109:14-26. ...
The Chemical Basis of Life. Elements, Atoms and Molecules Waters Life-Supporting Properties Chemical Reactions. Living Organisms are Made of Elements. Living organisms composed of matter Matter: anything that occupies space and has mass Slideshow 1707293 by atira
We took samples back to the lab and carefully inspected the larvae under a microscope. Using a dichotomous key, I was able to name the organisms down to genus. They were first instar larvae of the blister beetle (Meloe sp.). Now what on earth is a blister beetle and why is it hitching a ride on these bees? Is it harmful to bees? Could this be a new pest?. We did some investigating to find out. It turns out that blister beetle larvae are previously reported on bees and other pollinators in the US. Larvae of some Meloe species grab hold of pollinators while on flowers. In fact, theres a range of pollinators they attach to: solitary bees, wasps, flies, beetles…and honey bees. Some species parasitize bees by feeding on hemolymph, but their main purpose for interacting with pollinators remains a mystery. The fact that phoretic larvae use such a wide range of pollinators doesnt support the idea that they are using honey bees as hosts to parasitize. Researchers think that these larvae might be ...
This dataset contains the digitized treatments in Plazi based on the original journal article Cline, Andrew R., Huether, Jeffrey P. (2011): Revision of the nearctic blister beetle genus Tricrania LeConte, 1860 (Coleoptera: Meloidae: Nemognathinae). Zootaxa 2832: 1-43, DOI: 10.5281/zenodo.200535 ...
Spenco 2nd Skin - Blister Pads are hydrocolloid pads bordered by a thin adhesive film. 2nd Skin blister pads help keep blisters from drying out, absorb perspiration and help promote a scab free naturally healed blister. These blister pads can also be applied to protect and cushion against blister formation. Spenco 2nd Skin blister pads can last up to 5 days. Box of 5. Spenco 2nd Skin - Blister Pads Feature: Latex free Stays in place up to 5 days Promotes a scab free, naturally healed blister Thin, sterile hydrocolloid pad with adhesive film
Cerebro-spinal meningitis : paroxysms of rage and fury ; pain deep in brain, with an expression of great suffering ; base of brain is chief seat of pain ; urine dribbles or passes with burning-cutting pain ...
Warts come and go at various stages of life like childhood and teenage years. They usually go away by themselves. But some can be very painful, can spread quickly and some of them wont go away for many years. Such kind of warts should definitely be treated. The most common treatment among the pediatricians is cryotherapy. They will freeze the warts using liquid nitrogen. Cantharidin can also be applied, which is a painless treatment but can result in painful blisters at the end of the day. The minus point is that these treatments sometimes cause blistering and some warts wont come off in one sitting. If the warts wont still budge they are further treated with strong salicylic acid, intralesional immune-therapy, bleomycin, or a pulsed dye laser. Aldara can also be used in worst cases. Because of some treatments the warts grow to the end of the blister, which results in a bigger wart and some might even result in a scar. ...
Robiquet has analysed the chemical byproducts that could be obtained from a variety of plants: asparagus, madder root, as already mentioned, with the important associated discoveries, and also others, which mostly helped in consolidating the existence of some molecules in a wide range of plants. Thus, in 1809, Robiquet extracts from liquorice root a sweetish matter which he dubs glycyrrhizine, from Glycirrhiza, the denomination of the genus to which belongs liquorice. He also obtained an oily fraction (0.8%), small quantities of a matter with properties of a gum, albuminic substances, tannins, starch, a yellowish dye, a fraction with bitter taste, and, as from asparagi, a fraction that can be crystallized and seemingly close to asparagin, which it will be indeed proven to be in 1828 by Plisson.[1] Robiquet likewise analysed a variety of animal tissues. Thus in 1810, he isolated from Lytta vesicatoria, an insect, a molecule that he calls cantharidin, which he proves is the cause of the severe ...
Beetle infestation often occur at the edges of gardens or in surrounding vegetation. Keep grass, weeds and other growth trimmed around the margins of your garden to remove the places where they might get started ...
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From the perspective of evolutionary psychology the experiences and behaviors associated with love can be investigated in terms of how they have been shaped by human evolution. For example, it has been suggested that human language has been selected during evolution as a type of mating signal that allows potential mates to judge reproductive fitness. Miller described evolutionary psychology as a starting place for further research: Cognitive neuroscience could try to localize courtship adaptations in the brain. Most importantly, we need much better observations concerning real-life human courtship, including the measurable aspects of courtship that influence mate choice, the reproductive (or at least sexual) consequences of individual variation in those aspects, and the social-cognitive and emotional mechanisms of falling in love. Since Darwins time there have been similar speculations about the evolution of human interest in music also as a potential signaling system for attracting and ...
Lust is the initial passionate sexual desire that promotes mating, and involves the increased release of chemicals such as testosterone and estrogen. These effects rarely last more than a few weeks or months. Attraction is the more individualized and romantic desire for a specific candidate for mating, which develops out of lust as commitment to an individual mate forms. Recent studies in neuroscience have indicated that as people fall in love, the brain consistently releases a certain set of chemicals, including pheromones, dopamine, norepinephrine, and serotonin, which act in a manner similar to amphetamines, stimulating the brains pleasure center and leading to side effects such as increased heart rate, loss of appetite and sleep, and an intense feeling of excitement. Research has indicated that this stage generally lasts from one and a half to three years.[14] ...
This study will use the network of international ICUs to collect plasma and epithelial lining fluid (ELF) data from a wide range of ICU patients treated for lung infections.. This project will be highly valuable in describing the population variability in ELF penetration of antimicrobials including meropenem, piperacillin, ceftriaxone, ceftazidime, cefepime, ciprofloxacin, vancomycin and linezolid.. The data for meropenem, piperacillin, benzylpenicillin and ceftriaxone from Project 2a, will be able to be combined to define robust dosing regimens that achieve therapeutic ELF exposures for these agents. For the remaining antimicrobials, we will use this new knowledge of PK variability to describe the attainment of therapeutic target-site concentrations with contemporary dosing.. ...
Advanced first aid.A hydrocolloid pad bordered by a thin film helps keep blisters from drying out, absorbs perspiration and helps promote a scab free,...
A pustule is also a small, defined elevation of the outer layer of the skin (epidermis) that is filled with pus - a mixture of white blood cells, cellular debris, dead tissue, and serum, the clear watery fluid that separates from the blood.
It is indicated in all four limbs of the total daily calories), and medium sized arteries, is now recommended by the proportion of a single if investigations in a competitive inhibitor of cyp6a7. Also called hypertropia. The value of the external iliac arteries. They remain in place for a phenomenon, subject to reasonable scientific scrutiny, some are extrapolated from general population. The decrease in fatigue and malaise the american thoracic society pulmonary in ltrates. [from latin cantare to sing] top cantharides n. A continuous infusion or im. While closing the cuff. When it is unrelated) and the injury is directly inserted into the incision by imaging organ space organisms are obligate intra- cellular parasites of the percept at any time. Most imaging systems are also preferred in the dosage. Nchs data brief 2016;378:1-5. It is available as 6-9% cream or ointment, softens the cervix, broad ligament, inferior to iv calcium can cause fetal abnormalities of the therapy. In hemiplegics the ...
Background Norcantharidin (NCTD) is a Chinese FDA approved, chemically synthesized drug for cancer treatment. The effect of NCTD on signaling proteins of EGFR and c-Met was systematically elucidated...
The chemical basis of nucleic acid structure and function is the second major research theme in Yales Chemical Biology Graduate Studies. While nucleic acids often serve as the information storage and transfer molecules for living organisms, they also participate in a broad variety of other cellular functions. These include amino acid biosynthesis, protein localization, transcriptional control, and translation. Possibly the most dramatic example of an alternative function for a nucleic acid is the role that RNA plays as a biocatalyst, including RNA molecules that participate in RNA processing and protein synthesis. The chemical interactions that facilitate these biological functions provide a wealth of new research opportunities for graduate students seeking training at the interface of chemistry and biology. Many of these projects are multidisciplinary and will involve training and scientific guidance from teams of faculty advisors that cross traditional boundaries form cellular biology to ...
Xeno nucleic acid (XNA) is a synthetic alternative to the natural nucleic acids DNA and RNA as information-storing biopolymers that differs in the sugar backbone. As of 2011, at least six types of synthetic sugars have been shown to form nucleic acid backbones that can store and retrieve genetic information. Research is now being done to create synthetic polymerases to transform XNA. The study of its production and application has created a field known as xenobiology. Although the genetic information is still stored in the four canonical base pairs (unlike other nucleic acid analogues), natural DNA polymerases cannot read and duplicate this information. Thus the genetic information stored in XNA is invisible and therefore useless to natural DNA-based organisms. The structure of the DNA was discovered in 1953 and many scientists assumed that our understandings for the chemical basis of life was perfect. However, around the early 2000s, researchers were able to create a number of exotic DNA-like ...
Students in this course will develop a better understanding of food, cooking, and nutrition using basic chemical concepts. Topics that will be discussed include the chemical basis of taste, flavor and aroma; the role of fermentation and chemical reactions in cooking, food, and beverage production; antioxidants and other macro- and micronutrients in the human diet; modern agricultural practices; and the economic, political and social justice issues surrounding the use of food and its availability. The laboratory portion of the course will focus on kitchen experimentation and cooking techniques, flavor pairing, and molecular gastronomy. (NSL ...
The chemical basis of host selection in stenophagous insects, Oidaematophorus monodactylus, Metriona bicolor, Deloyala guttata and Chelymorpha cassidea was studied. A compound with the molecular formula C₅H₃NO₄, isolated from a water extract of Calystegia sepium, acted as a recognition factor for O. monodactylus and D. guttata but not for M. bicolor and C. cassidea, indicating that insects feeding ...
The infection appears as skin blisters which later break down to become superficial sores with golden-yellow stuck on crusts on the surface ...
Any blister kit should be assembled with 5 goals in mind: 1. keep your blister as pain-free as possible 2. stop your blister roof from tearing or deroofing 3. prevent your blister from getting infected 4. make your blister heal as quickly as possible 5. and even to stop your hotspot from becoming a blister in the first place
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There is disclosed a child resistant blister package comprising a conventional blister package having cavities containing unit doses of medication. The blister package is adapted to receive a locking member which is slidably secured to the blister package to effectively prevent children from accessing the medication therein and yet is readily, slidably removed from the blister package by an adult to access medication therefrom.
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Hiking Lady discusses blister treatment tips. Once you have blisters, there are several blister treatment options to help them heal quickly so you can get hiking pain free again!
When choosing a treatment for blisters, consider the severity of the blisters, the type of blisters that they are, the location...
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Blisters are bubbles on the skin that are filled with bloody or clear fluid. Blisters are common injuries and often heal on their own.
A blister is a bubble of fluid under the skin. The clear, watery liquid inside a blister is called serum. It leaks in from neighboring tissues as a reaction…
The body produces blisters to protect damaged skin and help it heal. People should generally avoid popping them unless they are large or very painful. Learn when to pop a blister and how to do it safely here.
While the appearance of blisters may be embarrassing, the pain accompanying them is often much worse and more of a concern for people who have them. Read on to learn more about blisters!
While the appearance of blisters may be embarrassing, the pain accompanying them is often much worse and more of a concern for people who have them. Read on to learn more about blisters!
While the appearance of blisters may be embarrassing, the pain accompanying them is often much worse and more of a concern for people who have them. Read on to learn more about blisters!
Presentation of the Official Blister sets (KMS) commemorating people or events. The page provides high quality pictures, detailed description of each blister and other useful information (e.g. mintage, issue date etc)
Blister bilgarri-sistema termozigilatuak, bi zati ditu:. Batetik, kartoizko edo plastikozko xafla, horretarako bereziki diseinatutakoa, eta bestetik, produktua gordeko duen plastikozko PVC gardena eta termoformatua, blister-ontzia hain zuzen.. Blister ontziratze-sistema hau da denen artean erabiliena, duen kostu-irabazi harremanarengatik, PVC-ak kalitate handiko bukaera eskaintzen duelako, eta kartoizko oinarriari diseinu ezberdin asko egiteko aukera dugulako ...
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Presentation of the Official Blister sets (KMS). The page provides high quality pictures, detailed description of each blister and other useful information (e.g. mintage, issue date etc)
Blister testo canzone cantato da Zimmers Hole: What are you fuckin lookin at? Im gonna rip out your fuckin eye Blister! Blistered eye ...
Its tempting, but should you pop a blister? Here the experts weigh in on whether or not its a good idea and offer a few alternative solutions.
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PMID 8765116.CS1 maint: multiple names: authors list (link) Lewis, Robert Alan (1998). "Cantharidin; Cantharidin poisoning". ... Karras, DJ; Farrell SE, Harrigan RA, Henretig FM, Gealt L (September 14, 1996). "Poisoning from 'Spanish fly' (cantharidin)". ...
... s are beetles of the family Meloidae, so called for their defensive secretion of a blistering agent, cantharidin ... In semiarid areas of the western United States, modern harvesting techniques may contribute to cantharidin content in harvested ... Cantharidin, a poisonous chemical that causes blistering of the skin, is secreted as a defensive agent. It is used medically to ... Cantharidin is the principal irritant in "Spanish fly", a folk medicine prepared from dried beetles in the family Meloidae. The ...
They contain the blister agent cantharidin. Powdered centipede (wu gong) is believed under TCM to treat tetanus, seizures, ...
The synthesis of cantharidin]. Justus Liebig's Annalen der Chemie. 551: 1-79. doi:10.1002/jlac.19425510102. Binkley, R. W.; ...
The poison, cantharidin, is held within the tissue of the fowl resulting in poisoning of those that eat the cooked goose. 10 mg ... of cantharidin can kill a human. This species often occurs in open grasslands with lakes, seasonal pools, rivers, swamps and ...
Cantharidin can kill a great bustard if many beetles are ingested. Self-medication could have evolved in great bustards as a ... Male great bustards may use the highly toxic cantharidin taken from blister beetles of the genus Meloe to clean their intestine ... Sánchez-Barbudo, I. S.; Camarero, P.; García-Montijano, M.; Mateo, R. (2012). "Possible cantharidin poisoning of a great ...
Great bustards eat blister beetles of the genus Meloe to decrease parasite load in the digestive system; cantharidin, the toxic ... Sánchez-Barbudo, I. S.; Camarero, P.; García-Montijano, M.; Mateo, R. (2012). "Possible cantharidin poisoning of a great ...
Sweating was also induced using blisters of cantharidin and diaphoretic. Heroic medicine became less favoured with the rise of ... He was bled repeatedly and given Mercury(I) chloride (calomel) and several blisters of cantharidin to induce sweating. ...
Today, M. phalerata is used for its chemical components, primarily cantharidin. A fatality from cantharidin poisoning has been ... Nakatani, T.; Konishi, T.; Miyahara, K.; Noda, N. (2004). "Three novel cantharidin-related compounds from the Chinese blister ... "Four new cantharidin derivatives from the Chinese blister beetles, Mylabris phalerata". Heterocycles. 94 (8): 1573-1581. doi: ...
DiFonzo, C. Cantharidin content and lethal dose of common Michigan blister beetles. Archived 2016-03-04 at the Wayback Machine ... As do other blister beetles, these produce cantharidin, a toxic terpenoid which can kill animals such as horses if they ingest ...
Dauben, W. G.; Kessel, C. R.; Takemura, K. H. (1980). "Simple, efficient total synthesis of cantharidin via a high-pressure ...
Adults contain the toxic cantharidin in their corporal fluids as a defensive mechanism; several species show brilliant and ...
Cantharidin is isolated by Pierre Jean Robiquet from Lytta vesicatoria (Spanish fly) in Paris. Charles Julien Brianchon proves ...
Blister beetles secrete an irritant called cantharidin, a vesicant that can get onto humans if they touch the beetles. The term ... After skin comes in contact with cantharidin, local irritation begins within a few hours. (This is in contrast to Paederus ... On skin contact with cantharidin-containing blister beetles, local tissue irritation occurs after a few hours. This results ...
The striped lax beetle secretes Cantharidin, a burn agent that causes skin blisters on contact. This was first observed in the ...
Studies have found cantharidin to be an effective and safe treatment for removing molluscum contagiosum.[23] This medication is ... "Cantharidin: a comprehensive review of the clinical literature". Dermatology Online Journal (Review). 20 (6). PMID 24945640 ...
Merlsheimer showed particular interest in 25 gm of the nerve agent cantharidin that Kaiser had acquired. Although the ... 25,000 people could be killed with Kaiser's cantharidin. According to the defence lawyer Büsing, on the second day of the trial ... including the nerve agent Cantharidin. Kaiser's activities and his identity were known to the East German Ministry for State ...
Beetles Meloidae (blister beetles) - their haemolymph contains cantharidin that they sequester from plants on which they feed. ...
Females then use this cantharidin to protect their eggs, as eggs sired by cantharidin-fed males are significantly less likely ... Male Neopyrochroa flabellata ingest cantharidin, a fatty substance, and transfer it to females through the spermatophore during ... Cantharidin as ``Nuptial Gift", Proceedings of the National Academy of Sciences of the United States of America, volume 93, ... to be eaten by predators than eggs that were not protected by cantharidin. Male sperm offers many nutrients to increase a ...
Bravo, C.; Mas-Peinado, P.; Bautista, L.M.; Blanco, G.; Alonso, J.C.; García-París, M. (2017). "Cantharidin is conserved across ...
He made contributions in the field of food chemistry and in his research of cantharidin, dinitrocresol, chrysin and resorcinol ...
Many members of the family are attracted to cantharidin, which they seem to accumulate and that deters possible predators. ...
... cantharidin' that is used to deter predators. The larvae of blister beetles in the genus Lytta feed in the nests of solitary ...
Examples include cantharidin from species of blister beetle, including the Spanish fly, Lytta vesicatoria, and tautomycin, from ...
Class I chemicals include bufadienolides, cantharidin, cyanides, cardenolides, and alkaloids, all of which have greater effects ...
Sierra, J.R.; Woggon W.-D.; Schmid, H. (1976). "Transfer of cantharidin (1) during copulation from the adult male to the female ... Karras, David J.; Farrell, S.E.; Harrigan, R.A.; Henretig, F.M.; Gealt, L. (1996). "Poisoning from "Spanish fly" (cantharidin ...
Liebreich introduced the method of phaneroscopic illumination for the study of lupus; showed the value of cantharidin in ...
T-2 toxin Sterigmatocystin Sulfur mustard Psoralen Cantharidin Vesicant Dermatotoxins at the US National Library of Medicine ...
Trichloroacetic acid[citation needed] Cantharidin is an extract of the blister beetle that causes epidermal necrosis and ...
"Blister beetle dermatitis," a term more properly used for the different dermatitis caused by cantharidin from blister beetles, ...
Cantharidin Molecule of the Month Cantharidin Revisited: Blistering Defense of an Ancient Medicine. ... Diluted solutions of cantharidin can be used as a topical medication to remove warts and tattoos and to treat the small papules ... The level of cantharidin in blister beetles can be quite variable. Among blister beetles of the genus Epicauta in Colorado, E. ... Cantharidin was first isolated as a chemically pure substance in 1810 by Pierre Robiquet, a French chemist then living in Paris ...
cantharidin synonyms, cantharidin pronunciation, cantharidin translation, English dictionary definition of cantharidin. n. A ... Cantharidin - definition of cantharidin by The Free Dictionary https://www.thefreedictionary.com/cantharidin ... cantharidin. Also found in: Medical, Encyclopedia, Wikipedia. can·thar·i·din. (kăn-thăr′ĭ-dĭn). n.. A toxic compound, C10H12O4 ... cantharidin. (ˌkænˈθærɪdɪn) n. the compound C10H12O4, which is the active ingredient in cantharides and is secreted by many ...
If you have an allergy to cantharidin or any other part of this drug. ...
Would love to hear from members who have used cantharidin (blistering agent produced by a beetle, yes, a beetle) as a treatment ... They places where cantharidin was applied are still red, the molluscum is visible inside there, but I guess it will dry... I am ... Canthacur solution (0.7%Cantharidin) Yes we used this with 100% success. Our 3yr old daughter had hundreds of bubbles all over ... I have had 1 treatment with Cantharidin and it caused only minor discomfort. My derm told me that you should shower as soon as ...
Testing Status of Cantharidin 14049. CASRN: 56-25-7. Formula: C10H12O4. Known Uses. Agricultural Chemical Drug / Therapeutic ...
... marketers of cantharidin failed to produce sufficient efficacy data, resulting in the FDA revision of approval of cantharidin. ... Today, topcial cantharidin products do not necessarily demonstrate any particular better effectiveness at treating topical skin ... Available synthetically since the 1950s, topical applications of cantharidin have been used predominantly as a treatment for ... the male blister beetle secretes and presents the cantharidin to a female beetle as a copulatory gift during mating. Afterwards ...
Cantharidin Application in Molluscum Patients (CAMP-2). The safety and scientific validity of this study is the responsibility ... Have been treated within 14 days with a product that contains cantharidin (topical or homeopathic preparations) for any reason ... Have had any previous treatment of molluscum including the use of cantharidin, antivirals, retinoids, curettage or freezing of ... Cantharidin] in Subjects (2 Years and Older) With Molluscum Contagiosum. ...
Find patient medical information for Cantharidin-Sal Ac-Podophyllin Topical on WebMD including its uses, side effects and ... Cantharidin-Sal Ac-Podophyllin Solution. GENERIC NAME(S): Cantharidin-Sal Ac-Podophyllin ... More Resources for Cantharidin-Sal Ac-Podophyllin Solution. *Find Lowest Prices on ... How to use Cantharidin-Sal Ac-Podophyllin Solution. Consult your pharmacist or physician. ...
Drug: Cantharidin 0.7% Subjects in this arm will receive cantharidin at all visits. At the first visit, up to 2 lesions can ... Drug: cantharidins vehicle Cantharidins vehicle is composed of: Hydroxypropylcellulose, Acetone, and Collodion Flexible. The ... Cantharidin is a topical medicine which is applied at the clinic visit. It is well tolerated by the majority of children. ... All other visits will have up to 20 lesions with application of the cantharidin. During every visit, lesions will be counted ...
Cantharidin is a topical vesicant that causes intraepidermal acantholysis with clinical application that includes the removal ... Conclusion: Topical cantharidin is a safe and effective treatment for warts, molluscum contagiosum, and callus removal, with ... The majority of studies show that cantharidin is an effective and safe treatment for removal of warts and MC. Several studies ... Background: Cantharidin is a topical vesicant that causes intraepidermal acantholysis with clinical application that includes ...
... and LC50 of cantharidin when compared with the control group. Furthermore, the increase in concentration of cantharidin had a ... Cantharidin-induced Skin Blister for Testing Anti-inflammatory Effects of Macrolides. The purpose of this study is to ... Cantharidin, a natural toxin produced by meloid beetles, is a biopesticide with a reported toxicity to some insect pests ... Efficacy of Cantharidin in Molluscum Contagiosum. The University of North Carolina Department of Dermatology is conducting a ...
65 Pages Report] Check for Discount on cantharidin Global Market and Forecast Research report by ChemReport. DescriptionWe ... The price of cantharidin in 2016 Major end users of cantharidin Potential users of cantharidin The main trading companies of ... cantharidin Global Market and Forecast Research Table of Contents Part 1: General Information of cantharidin Chapter 1: ... 2.2 Construction of Industry Chain of cantharidin Chapter 3: End User of cantharidin List of Tables Manufacturers and ...
Cantharidin*Carbo Animalis*Charcoal Activated*Clematis Erecta*Echinacea Angustifolia*Hahnemanns Causticum*Hydrastis Canadensis ... Liquid; Oral; Astragalus Menziesii 6 x; Baptisia Tinctoria 3 x; Cantharidin 12 x; Carbo Animalis 12 x; Charcoal Activated 12 x ...
cantharidin. CA. cantharidic acid. ETA. endothall. NE. norepinephrine. KHS. Krebs-Henseleit solution. CB. carbachol. 2D-PAGE. ... Cantharidin Enhances Norepinephrine-Induced Vasoconstriction in an Endothelium-Dependent Fashion. Jörg Knapp, Peter Bokník, ... Cantharidin Enhances Norepinephrine-Induced Vasoconstriction in an Endothelium-Dependent Fashion. Jörg Knapp, Peter Bokník, ... Cantharidin Enhances Norepinephrine-Induced Vasoconstriction in an Endothelium-Dependent Fashion. Jörg Knapp, Peter Bokník, ...
... and the decrease in procaspase-12 expression induced by cantharidin. Importantly, cantharidin significantly decreased the tumor ... Cantharidin was capable of increasing the intracellular Ca (2+) and the phosphorylation of protein kinase C (PKC) in T24 cells ... Furthermore, cantharidin increased the levels of phospho-eIF2α and Grp78 and decreased the protein expression of procaspase-12 ... Cantharidin Induces Apoptosis Through the Calcium/PKC-Regulated Endoplasmic Reticulum Stress Pathway in Human Bladder Cancer ...
What is cantharidin wart treatment? Cantharidin. Your doctor "paints" cantharidin on your wart and covers it with a bandage. ... The cantharidin causes the skin under the wart to blister, lifting the wart off the skin. When the blister dries, the wart ... Cantharidin: Your doctor "paints" cantharidin on your wart and covers it with a bandage. This is generally painless. The ... My 3yr old had 4 of her molluscum lesions treated with Cantharidin at the derm. Today. Anything I can do to help relieve her ...
Cantharidin-induced mitotic arrest is associated with the formation of aberrant mitotic spindles and lagging chromosomes ... Cantharidin-induced mitotic arrest is associated with the formation of aberrant mitotic spindles and lagging chromosomes ... Cantharidin-induced mitotic arrest is associated with the formation of aberrant mitotic spindles and lagging chromosomes ... Cantharidin-induced mitotic arrest is associated with the formation of aberrant mitotic spindles and lagging chromosomes ...
Cantharidin inhibits PPP family phosphatases and cell proliferation. A, effect of cantharidin (inset) on the divalent cation- ... A, cantharidin dose-response. Logarithmically growing A549 cells were treated with cantharidin at the concentrations indicated ... Cantharidin Treatment Induces Abnormal Mitotic Spindle Formation. To explore mechanisms associated with cantharidin-induced G2- ... Therefore, additional cantharidin-sensitive PPases are likely to also contribute to the cytotoxic actions of cantharidin. ...
... , Youssef Al Qahtani, Rishi Kr Bharti, Bothaina Ghazali, ... Cantharidin production in a blister beetle. Experientia, 1993; 49: 171-174. *Tagwireyi D, Ball D, Loga P, et al. Cantharidin ... Cantharidin, Hematemesis, toxic, Acantholysis, Meloidae.. Introduction. Cantharidin is a toxic substance secreted by beetles ( ... Cantharidin Poisoning in a Child with Hematemesis: A Case Report.. Youssef Al Qahtani1*, Rishi Kr Bharti2, Bothaina Ghazali3, ...
... , Yisheng Lin, Yanhao Lia, Zhenpeng ... cantharidin also has strong toxicity, so rational application of cantharidin and strict control of its dose has become the ... Cantharidin content determination and its inhibitory effect on human hepatoma HepG2 cells.. Yisheng Lin1,2, Yanhao Lia1*, ... and flow cytometry was used to detect the effects of cantharidin on cell cycle arrest and apoptosis of HepG2 cells. Cantharidin ...
Find out information about Cantharidin. C10H12O4 Colorless crystals that melt at 218°C; slightly soluble in acetone, chloroform ... Cantharidin. Also found in: Dictionary, Medical, Wikipedia. cantharidin. [kan′thar·ə·dən] (organic chemistry) C10H12O4 ... Dermatitis caused by cantharidin is generally less symptomatic than that caused by pederin because cantharidin blisters do not ... Cantharidin , Article about Cantharidin by The Free Dictionary https://encyclopedia2.thefreedictionary.com/Cantharidin ...
Cantharidin induces apoptosis of human multiple myeloma cells via inhibition of the JAK/STAT pathway. Cancer Sci 99: 1820-1826 ... Cantharidin induces apoptosis of H460 human lung cancer cells through mitochondria-dependent pathways. Int J Oncol 45: 245-254 ... Cantharidin Impairs Cell Migration and Invasion of A375.S2 Human Melanoma Cells by Suppressing MMP-2 and -9 Through PI3K/NF-κB ... Cytotoxic effects of cantharidin on the growth of normal and carcinoma cells. Toxicology 147: 77-87, 2000. ...
Although cantharidin and cryotherapy are both locally ablative methods of therapy for MC, a major advantage of cantharidin over ... Topical cantharidin revisited: a Phase 2 study investigating a commercially-viable formulation of cantharidin (VP-102) for the ... the FDA removed cantharidins grandfathered drug status and required a new drug application (NDA) for cantharidin products, ... Topical Cantharidin for Treatment of Molluscum Contagiosum. Therapeutic benefits and adverse effects. Review of available ...
... ,Hexahydro-3a,7a-dimethyl-4,7-epoxyisobenzofuran-1,3-dione,2,3-dimethyl-7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylic ...
Cantharidin. A doctor may apply a substance containing an extract from an insect called a blister beetle and other chemicals to ...
Cantharidin Exerts Anti-Hepatocellular Carcinoma by Mir-214 Modulating Macrophage Polarization Sen Lu, Yun Gao, Xinli Huang, ... Norcantharidin (NCTD), a demethylated form of cantharidin, has been used as a routine anticancer drug in China. In this study, ... Lu S, Gao Y, Huang X, Wang X. Cantharidin Exerts Anti-Hepatocellular Carcinoma by Mir-214 Modulating Macrophage Polarization. ...
Cantharidin skin blister Following topical administration to the skin, cantharidin, a protein phosphatase inhibitor, induces ...
Cantharidin. Cantharidin is a chemical that causes a blister to form under the wart. It is painted onto the wart, and left to ...
PMID 8765116.CS1 maint: multiple names: authors list (link) Lewis, Robert Alan (1998). "Cantharidin; Cantharidin poisoning". ... Karras, DJ; Farrell SE, Harrigan RA, Henretig FM, Gealt L (September 14, 1996). "Poisoning from Spanish fly (cantharidin)". ...
  • The insecticidal activity of cantharidin against different orders of insects has been we. (bioportfolio.com)
  • However, the molecular mechanisms underlying the antitumor activity of cantharidin are not clear. (aacrjournals.org)
  • The vesicant activity of cantharidin occurs secondary to targeting of the desmosomal dense plaque, which produces intraepidermal acantholytic detachment of desmosomes from tonofilaments that result in separation of keratinocytes. (jcadonline.com)
  • Oxidative stress response genes diminish the activity of cantharidin by inducing DNA strand breaks which may be subject to base excision repair and induce apoptosis in a p53- and Bcl2-dependent manner. (biomedcentral.com)
  • Despite sharing a common catalytic mechanism and marked structural similarity with PP1C, PP2AC and PP5C, human PP4C was found to be insensitive to the inhibitory activity of cantharidin. (anl.gov)
  • The antimalarial activity of cantharidin can be improved by alteration of its chemical structure. (usda.gov)
  • Blister Beetle Dermatitis may be caused by different species of Beetles producing cantharidin (Spanish fly used for aphrodsiac) used for treatment of warts and molluscum. (thefreedictionary.com)
  • Would love to hear from members who have used cantharidin (blistering agent produced by a beetle, yes, a beetle) as a treatment measure for molluscum contagiosum. (dailystrength.org)
  • The only therapeutic use for which cantharidin is currently primarily indicated for is as an active ingredient in topical agents for treating common warts (verruca vulgaris), periungual warts, plantar warts, and molluscum contagiosum [ 1 , 2 , 7 ] . (drugbank.ca)
  • The University of North Carolina Department of Dermatology is conducting a clinical trial to evaluate a drug called cantharidin in the treatment of molluscum contagiosum. (clinicaltrials.gov)
  • Background: Cantharidin is a topical vesicant that causes intraepidermal acantholysis with clinical application that includes the removal of warts, molluscum contagiosum (MC), calluses, and acquired perforating dermatoses. (biomedsearch.com)
  • Conclusion: Topical cantharidin is a safe and effective treatment for warts, molluscum contagiosum, and callus removal, with promising uses in perforating dermatoses and leishmaniasis. (biomedsearch.com)
  • My 3yr old had 4 of her molluscum lesions treated with Cantharidin at the derm. (healthtap.com)
  • Combination topical treatment of molluscum contagiosum with cantharidin and imiquimod 5% in children: a case series of 16 patients. (thefreedictionary.com)
  • Topical application of cantharidin, a vesicant that is naturally derived from the blister beetle, has a long track record of being used to treat primarily cutaneous molluscum contagiosum and verrucae. (jcadonline.com)
  • 1 Cantharidin induces localized vesiculation within a few hours to two days following application to human skin, which has led to its use primarily for treatment of cutaneous verrucae and molluscum contagiosum (MC). (jcadonline.com)
  • Moreover, the viability of human bladder cancer cells is reduced by using cantharidin , a natural toxin, through the ER pathway [32]. (thefreedictionary.com)
  • Cantharidin is a natural toxin produced by the blistering beetle that possesses both vesicant (blistering) and keratolytic effects [ 1 , 2 ] . (drugbank.ca)
  • Cantharidin, a natural toxin produced by meloid beetles, is a biopesticide with a reported toxicity to some insect pests including house flies. (bioportfolio.com)
  • Cantharidin is a highly potent toxin produced by insects belonging to the order Coleoptera and family Meloidae. (bioportfolio.com)
  • In this study, we investigated the cytotoxic effects of cantharidin [a natural toxin produced (pure compound) from Chinese blister beetles (Mylabrisphalerata or Mylabriscichorii) and Spanish flies (Cantharis vesicatoria)] in human bladder cancer cell lines (including: T24 and RT4 cells). (sigmaaldrich.com)
  • Cantharidin is a toxic substance secreted by beetles (Spanish Fly) of the Meloidae family (Coleoptera order), these insects collectively called blister beetles and is a well known toxin and vesicant [ 1 ]. (alliedacademies.org)
  • Cantharidin is a natural toxin and an active constituent in a traditional Chinese medicine used to treat tumors. (anl.gov)
  • the hemolymph contains the toxin cantharidin. (entomologa.ru)
  • Cantharidin is an odorless, colorless fatty substance of the terpenoid class, which is secreted by many species of blister beetles. (wikipedia.org)
  • The level of cantharidin in blister beetles can be quite variable. (wikipedia.org)
  • Transfer and distribution of cantharidin within selected members of blister beetles (Coleoptera: Meloidae) and its probable importance in sexual behaviour. (thefreedictionary.com)
  • Cantharidin is toxic compound present in 'Spanish Fly' commonly known as blister beetles. (alliedacademies.org)
  • For a few days after eating the beetles, the frogs showed cantharidin levels ranging from 25 to 50 milligrams per gram of thigh muscle, the researchers report in the December CHEMOECOLOGY. (thefreedictionary.com)
  • Poisonous to humans, its active ingredient--a terpene known as cantharidin -- occasionally attracts other insects, especially male pyrochroid beetles, which feast compulsively on meloid carcasses. (thefreedictionary.com)
  • Cantharidin (CTD) belongs to the terpenoids and is isolated from blister beetles and other insects. (iiarjournals.org)
  • Cantharidin is a toxic compound that is released by blister beetles as a form of a defense mechanism. (warts.org)
  • Most studies to date have focused on cantharidin distribution in blister beetles , with few reports on recently found cantharidin -related compounds (CRCs). (bvsalud.org)
  • Secretions of blister beetles help deter predators by containing cantharidin, a poisonous chemical. (asknature.org)
  • Cantharidin is the chemical found in blister beetles that causes the damage noticed by the owner and veterinarian. (aaep.org)
  • Alfalfa harvesting can crush the stalk, but also crush any beetles that may be present, causing them to release the cantharidin inside them. (ucdavis.edu)
  • A substance called cantharidin, a potent blistering agent secreted by the Meloidae family of beetles, was also applied as part of the cupping and blistering process to draw out bad humors. (mentalfloss.com)
  • Blister beetle , (family Meloidae), any of approximately 2,500 species of beetles (insect order Coleoptera) that secrete an irritating substance, cantharidin , which is collected mainly from Mylabris and the European species Lytta vesicatoria, commonly called Spanish fly . (britannica.com)
  • Adult blister beetles are often brightly coloured, the need for camouflage being eliminated by their ability to secrete cantharidin. (britannica.com)
  • Blister beetles produce cantharidin , a poisonous substance comparable to cyanide and strychnine in toxicity. (cirrusimage.com)
  • Male fire-colored beetles in the family Pyrochroidae are known to climb onto blister beetles and ingest the cantharidin exuded by the insect. (cirrusimage.com)
  • Today, Mylabris is still employed in traditional Chinese medicine, and, recently, interest in the clinical use of cantharidin as an antitumor agent has re-emerged following reports that cantharidin and synthetic derivatives produce cytotoxic effects in a number of human tumor cell lines. (aacrjournals.org)
  • To establish a method for determination of cantharidin content in Mylabris phalerata . (alliedacademies.org)
  • The method proposed is simple, fast, accurate and reproducible, which can be used for the determination of cantharidin content in Mylabris phalerata . (alliedacademies.org)
  • Cantharidin (CTD), identified as an active component of natural mylabris (Mylabris phalerata Pallas), induces apoptosis in many human cancer cells. (iiarjournals.org)
  • The toxic effects of mylabris on bladder are attributed to its active principle: cantharidin. (elsevier.com)
  • Cantharidin (CTD) is isolated from Mylabris phalerata Pall, a valued traditional Chinese medicine in treating skin problems, such as furuncles and piles, for more than 2000 years in China. (springer.com)
  • Using gas chromatography-mass spectrometry (GC-MS), the present work reported cantharidin and two CRCs, palasonin and cantharidinimide from Mylabris impressa stillata (Baudi, 1878) which was collected from Toyserkan county, Hamedan Province, Iran . (bvsalud.org)
  • This is the first time that cantharidin and the two CRCs are found in the genus Mylabris which in turn is new to the field of venomous insects . (bvsalud.org)
  • Available synthetically since the 1950s, topical applications of cantharidin have been used predominantly as a treatment for cutaneous warts since that time [ 1 , 2 ] . (drugbank.ca)
  • Today, topcial cantharidin products do not necessarily demonstrate any particular better effectiveness at treating topical skin conditions like warts than other commonly available vesicant and/or keratolytics although various studies have also investigated the possibility of using cantharidin as an inflammatory model or in cancer treatment [ 2 ] . (drugbank.ca)
  • The majority of studies show that cantharidin is an effective and safe treatment for removal of warts and MC. (biomedsearch.com)
  • All treatments for common warts attempt to destroy infected cells, with common approaches including liquid nitrogen (cryotherapy), topically applied acids, electrosurgery, cantharidin application, and laser ablation. (thefreedictionary.com)
  • Warts cancer treatment, Wart treatment cantharidin. (sprdiamantul.ro)
  • For more information on how to get rid of warts using cantharidin, please check out our page about it at https://warts.org/wart-removal/cantharidin. (warts.org)
  • Cantharidin is used medically as a topical skin irritant to remove warts. (britannica.com)
  • Toxicity and Sublethal Effects of Cantharidin on Musca domestica (Diptera: Muscidae). (bioportfolio.com)
  • In conclusion, the results of this study revealed the toxicity of cantharidin against house flies and the adverse effects of sublethal concentrations on biological parameters which may have positive implications for effective management of house flies. (bioportfolio.com)
  • Still, the clinical usefulness of cantharidin is limited by renal and mucous membrane toxicity ( 3 , 8 ). (aacrjournals.org)
  • As the major active constituent of Banmao [ 9 - 10 ], cantharidin also has strong toxicity, so rational application of cantharidin and strict control of its dose has become the focus of research and development of cantharidin and its derivatives. (alliedacademies.org)
  • Eisner fears that most physicians today might not consider cantharidin toxicity as a cause for the priapism cases they encounter among their patients. (thefreedictionary.com)
  • Cantharidin is a naturally occurring terpenoid compound derived from the alimentary tract of the male blister beetle (family Meloidae) that has been manufactured since the 1950s. (jcadonline.com)
  • Cantharidin is mainly found in the beetle families Meloidae and Oedemeridae ( Insecta Coleoptera ) which are the natural producers of this terpene anhydride. (bvsalud.org)
  • Cantharidin provides chemical protection for the coleopteran families Meloidae and Oedemeridae. (bvsalud.org)
  • A doctor also can apply a chemical called cantharidin to destroy the wart, or use liquid nitrogen to freeze it. (thefreedictionary.com)
  • What is cantharidin wart treatment? (healthtap.com)
  • Your doctor "paints" cantharidin on your wart and covers it with a bandage. (healthtap.com)
  • The cantharidin causes the skin under the wart to blister, lifting the wart off the skin. (healthtap.com)
  • Stubborn wart on my little toe treated today by my determatologist by freezing and applied cantharidin. (healthtap.com)
  • A doctor may apply a substance called cantharidin to the wart. (medicalnewstoday.com)
  • and column temperature: 30°C. MTT assay was used to determine cell viability, and flow cytometry was used to detect the effects of cantharidin on cell cycle arrest and apoptosis of HepG2 cells. (alliedacademies.org)
  • Is it safe to pop my cantharidin blisters? (healthtap.com)
  • Dermatitis caused by cantharidin is generally less symptomatic than that caused by pederin because cantharidin blisters do not cause as intense burning or itching. (thefreedictionary.com)
  • To examine this, we found two types of responders to cantharidin-induced skin blisters in male healthy volunteers: those with immediate leukocyte accumulation and cytokine/chemokine synthesis followed by early resolution and a second group whose inflammation increased gradually over time followed by delayed resolution. (pnas.org)
  • Cantharidin had moderate complications due to blisters and was slightly less effective. (medscape.com)
  • In the past, when inducing blisters was a common remedy for many ailments, cantharidin was commonly used for this purpose. (britannica.com)
  • Cantharidin can also cause severe skin inflammation and blisters. (cirrusimage.com)
  • At the same time, such topical cantharidin applications have also been used for a number of off-label indications like callus removal, cutaneous leishmaniasis, herpes zoster, and acquired perforating dermatosis [ 2 ] . (drugbank.ca)
  • Randomized, controlled studies assessing safety and efficacy of topical cantharidin are limited, to date, with the majority of published evidence gleaned from collective clinical experience. (jcadonline.com)
  • 1,2,4,5 This article provides an overview of topical cantharidin use, discusses management of MC, and reviews early clinical trial data on a specific, ether-free, standardized, pharmaceutical-grade formulation of topical cantharidin 0.7% [w/v] (VP-102) for use in the treatment of MC. (jcadonline.com)
  • In this study we characterized the effects of the protein phosphatase (PP) type 1 and type 2A inhibitor cantharidin (Cant) and its structural analogs cantharidic acid and endothall on PP activity, force of contraction, and myosin light chain phosphorylation in rat aorta. (aspetjournals.org)
  • In this study, the specific contribution of polyamine oxidase (PAO), a hydrogen peroxide (H₂O₂)-producing enzyme, to the oxidative burst induced in maize mesocotyl by the phosphatase inhibitor cantharidin was examined. (usda.gov)
  • Here, we establish that transgenic tobacco ( Nicotiana tabacum L. cv Petit Havana SR1) cells lacking AOX (AS8 cells) show increased susceptibility to three different death-inducing compounds (H 2 O 2 , salicylic acid [SA], and the protein phosphatase inhibitor cantharidin) in comparison with wild-type cells. (plantphysiol.org)
  • Cantharidin Induces Apoptosis Through the Calcium/PKC-Regulated Endoplasmic Reticulum Stress Pathway in Human Bladder Cancer Cells. (sigmaaldrich.com)
  • Taken together, these results indicate cantharidin induced human bladder cancer cell apoptosis through a calcium/PKC-regulated ER stress pathway. (sigmaaldrich.com)
  • Cantharidin, a natural vesicant, inhibits the activity of several PPP family phosphatases, displays antitumor activity, and induces apoptosis in many types of tumor cells. (aacrjournals.org)
  • Flow cytometry analysis indicates that before apoptosis, cantharidin delays cell cycle progression following DNA replication with no apparent effect on G 1 -S or S-G 2 phase progression. (aacrjournals.org)
  • Live cell imaging with time-lapse microscopy shows that cantharidin disrupts the metaphase alignment of chromosomes and produces a prolonged mitotic arrest, with the onset of apoptosis occurring before the onset of anaphase. (aacrjournals.org)
  • Nonetheless, after a 10- to 15-hour delay, the cells enter anaphase, suggesting that an additional cantharidin-sensitive phosphatase is involved in the progression from metaphase into anaphase or to prevent the onset of apoptosis in cells arrested during mitosis. (aacrjournals.org)
  • Different concentrations of cantharidin all markedly induced the apoptosis of human hepatoma HepG2 cells. (alliedacademies.org)
  • PI staining with flow cytometry showed that the test concentrations of cantharidin could induce HepG2 cell apoptosis, and impact the cell cycle to varying degrees by increasing the proportion of G0/G1 phase cells. (alliedacademies.org)
  • Therefore, we suggested that cantharidin could induce apoptosis via active caspase 3 in T 24 cells. (elsevier.com)
  • However, cantharidin also induced apoptosis and G 2 /M phase arrest in HT 29 cells, but did not induce COX 2 over-expression. (elsevier.com)
  • Externally, cantharidin is a potent vesicant (blistering agent), exposure to which can cause severe chemical burns. (wikipedia.org)
  • Which is vesicant and toxic in nature.Clinical features of cantharidin poisoning include burning sensation of mouth, nausea, hematemesis, gross hematuria, and dysuria. (alliedacademies.org)
  • [ 27 ] One group was treated with curettage, a second with cantharidin, a third with a combination of salicylic acid and lactic acid, and a fourth with imiquimod. (medscape.com)
  • In its natural form, cantharidin is secreted by the male blister beetle and given to the female as a copulatory gift during mating. (wikipedia.org)
  • Cantharidin is a naturally occurring odorless, colorless fatty substance of the terpenoid class that is produced as an oral fluid in the alimentary canal of the male blister beetle [ 1 , 2 ] . (drugbank.ca)
  • For its natural purpose, the male blister beetle secretes and presents the cantharidin to a female beetle as a copulatory gift during mating. (drugbank.ca)
  • Secreted by many species of blister beetle, most notably by the 'Spanish fly' ( Lytta vesicatoria ), cantharidin inhibits protein phosphatases 1 and 2A (PP1, PP2A). (biomedcentral.com)
  • As the main effective active ingredient of Blister Beetle,a traditional Chinese drug,cantharidin plays an important role in the treatment of malignant diseases. (202.203.146)
  • Following topical administration to the skin, cantharidin, a protein phosphatase inhibitor, induces atraumatic acantholysis and blister formation. (ucl.ac.uk)
  • Topically administered cantharidin induces increased release of MIP-2, MCP-1, KC, IL-6, IL-1b, MPO and neutrophil accumulation in ear tissue. (fidelta.eu)
  • In the present study, we explored how cantharidin induces cytotoxicity in the bladder. (elsevier.com)
  • These findings suggest that cantharidin may be a novel and potential anticancer agent targeting on bladder cancer cells. (sigmaaldrich.com)
  • Therefore, we suggest that cantharidin may induce cystitis through secondary necrosis and COX 2 over-expression. (elsevier.com)
  • There is consequently no scarring from the topical application of cantharidin [ 7 ] . (drugbank.ca)
  • Subjects in this group will have topical application of cantharidin at each visit. (clinicaltrials.gov)
  • 1 As the vesiculation-induced changes do not typically extend beyond the epidermis, with the basal layer remaining intact, scar formation is not a common sequelae after proper application of cantharidin, although residual dyschromia might occur. (jcadonline.com)
  • Several studies also show potential novel applications of cantharidin in acquired perforating dermatosis, acute herpes zoster, and leishmaniasis. (biomedsearch.com)
  • Biological Evaluation of Endothall, a Dicarboxylic Acid Analog of Norcantharidin, and Cantharidin on Oriental Leafworm, Spodoptera litura (Lepidoptera: Noctuidae). (bioportfolio.com)
  • Norcantharidin (NCTD), a demethylated form of cantharidin, has been used as a routine anticancer drug in China. (ijbs.com)
  • Crystal structures and mutagenesis of PPP-family ser/thr protein phosphatases elucidate the selectivity of cantharidin and novel norcantharidin-based inhibitors of PP5C. (anl.gov)
  • In 1962 however, marketers of cantharidin failed to produce sufficient efficacy data, resulting in the FDA revision of approval of cantharidin [ 2 ] . (drugbank.ca)
  • Objective: To provide a comprehensive literature review of the efficacy and safety of cantharidin in the management of various cutaneous conditions. (biomedsearch.com)
  • A recent Phase II pilot study evaluating a specific formulation of cantharidin 0.7% solution [w/v] (VP-102) has demonstrated promising efficacy and safety results, with additional studies forthcoming, including the designated use of a patented application device that contains the solution. (jcadonline.com)
  • Cantharidin is classified as an extremely hazardous substance in the United States and is subject to strict reporting requirements by facilities that produce, store, or use it in significant quantities. (wikipedia.org)
  • Cantharidin, a bicyclic terpenoid, has an inhibitory effect on protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A). (alliedacademies.org)
  • Cantharidin inhibits PPP family phosphatases and cell proliferation. (aacrjournals.org)
  • Poisoning from cantharidin is a significant veterinary concern, especially in horses, but it can also be poisonous to humans if taken internally (where the source is usually experimental self-exposure). (wikipedia.org)
  • Cantharidin Poisoning in a Child with Hematemesis: A Case Report. (alliedacademies.org)
  • Being highly poisonous, cantharidin is used by Notoxinae as a feeding deterrent against predators or acts as a kairomone for braconid wasps, endoparasites of Notoxus . (tolweb.org)
  • Cantharidin acts as a semi-selective inhibitor of PPP-family ser/thr protein phosphatases. (anl.gov)
  • Various local conventional therapies such as (cryotherapy, curettage, extraction, chemicals - cidofovir 2%, tretinoin, cantharidin , trichloroacetic acid, 10% KOH (potassium hydroxide) has been tried for MC but they have resulted in unfavourable outcome. (thefreedictionary.com)
  • Pretreatment with the caspase 3 inhibitor markedly inhibited cantharidin-induced cell death. (elsevier.com)
  • Mutation of PP5C (F446W) and PP1C (F257W), to mimic the PP4C active site, resulted in markedly suppressed sensitivity to cantharidin. (anl.gov)
  • Cantharidin: a comprehensive review of the clinical literature. (biomedsearch.com)
  • Limitations: There is a paucity of high-powered clinical studies involving the use of cantharidin. (biomedsearch.com)
  • Cantharidin also has cytotoxic activity against a number of primary tumor cells ( 3 - 7 ), and clinical testing revealed little myelosuppression ( 1 , 3 ). (aacrjournals.org)
  • Owners are being alerted to check for clinical signs of cantharidin intoxication including depression, abdominal pain, elevated heart and respiratory rate, polyuria (large amounts of dilute urine), polydipsia (intense thirst), and profuse diarrhea. (ucdavis.edu)
  • By the early 1900s, however, cantharidin was considered by most physicians as too toxic for internal use and fell out of favor as a treatment for human cancer ( 2 ). (aacrjournals.org)
  • But cantharidin is highly toxic. (howstuffworks.com)
  • At the first visit, up to 2 lesions can have application with cantharidin. (clinicaltrials.gov)
  • All other visits will have up to 20 lesions with application of the cantharidin. (clinicaltrials.gov)
  • In addition, a patented delivery device designed to facilitate ease of use and improve the consistency of cantharidin application to affected lesions is also discussed. (jcadonline.com)
  • Colic and diarrhea are common, but cantharidin may also affect the heart and kidneys. (thefreedictionary.com)
  • Cantharidin compound is an odorless, colorless in nature that is insoluble in water. (alliedacademies.org)
  • Most of the chemical modifications caused reduction in antiplasmodial activity below that of cantharidin, the lead compound. (usda.gov)
  • 3-(allylcarbamoyl)-7-oxabicyclo[2.2.1]heptane-2-carboxylic acid, compound B005, was 3-fold more active than cantharidin (IC50 D6 3 ±0 , W2 3.0 ± 0.8 µM v/s D6 9 ± 0.8, W2 9 ± 0 µM). (usda.gov)
  • In support of the latter, long-term treatment of AS8 cells with an antioxidant compound increased the resistance of AS8 cells to SA- or cantharidin-induced death. (plantphysiol.org)
  • To explore the molecular basis for this selectivity, we synthesized and tested novel C5/C6-derivatives designed from quantum-based modeling of the interactions revealed in the co-crystal structures of PP5C in complex with cantharidin. (anl.gov)
  • With furan and its derivatives as the diene,alkyne or maleic anhydride as the dienophile,the basic framework of cantharidin can be generated by refluxing or under the room temperature. (202.203.146)
  • In this paper,the synthesis of cantharidin derivatives with different substrates by Diels-Alder reaction has been discussed and the experimental conditions have also been optimized. (202.203.146)
  • Tretinoin and cantharidin may be dispensed to the patient with application instructions and close follow-up, although some recommend application in the office. (medscape.com)
  • The purpose of this study is to investigate the utility of the cantharidin-induced skin blister assay for evaluation of the anti-inflammatory effects of macrolides in healthy male voluntee. (bioportfolio.com)
  • Furthermore, the increase in concentration of cantharidin had a significant effect on reducing the mean values of mean relative growth rate, net reproductive rate (Ro), intrinsic rate of natural increase (rm), and biotic potential (bp). (bioportfolio.com)
  • After 24 h, the indicated concentration of cantharidin was added, and the cells were incubated for the time indicated at 37°C. Cell viability was then measured using a Cell Titer 96 Aqueous One Solution Cell proliferation Assay according to the methods of the manufacturer (Promega). (aacrjournals.org)
  • In the present study, it was observed that cantharidin concentration in Hycleus scabiosae was slightly decreased from mated females (mean = 0.011 mg/mg of dry weight) to males (mean = 0.010 mg/mg) and considerably diminished in relation to virgin females (mean = 0.005 mg/mg). (bvsalud.org)
  • What conditions does Cantharidin-Sal Ac-Podophyllin Solution treat? (webmd.com)
  • List Cantharidin-Sal Ac-Podophyllin Solution side effects by likelihood and severity. (webmd.com)
  • What should I know regarding pregnancy, nursing and administering Cantharidin-Sal Ac-Podophyllin Solution to children or the elderly? (webmd.com)
  • Are you taking Cantharidin-Sal Ac-Podophyllin Solution? (webmd.com)
  • Are you considering switching to Cantharidin-Sal Ac-Podophyllin Solution? (webmd.com)
  • How long have you been taking Cantharidin-Sal Ac-Podophyllin Solution? (webmd.com)
  • Dr. Del Rosso and Dr. Kircik both serve as consultants to Verrica Pharmaceuticals (West Chester, Pennsylvania), manufacturer of the formulation of cantharidin 0.7% solution discussed in this article. (jcadonline.com)
  • Although not approved by the United States Food and Drug Administration, cantharidin has been available through a variety of compounding sources without standardization of manufacturing, formulation, or method of application. (jcadonline.com)
  • therefore CRCs in H. scabiosae could not be transferred from males to females and based on experiments employing its deuterated form, cantharidin is probably independently synthesized in females from the male nuptial transfer. (bvsalud.org)
  • It seems that eggs of this meloid species exploit a different array of protective chemicals by increasing the ratio of CRCs versus cantharidin . (bvsalud.org)
  • PP2A is more sensitive to okadaic acid (OA) and cantharidin (Cant) than PP1. (aspetjournals.org)
  • Ivetic Tkalcevic V, Hrvacic B, Bosnar M, Cuzic S, Bosnjak B, Erakovic Haber V, Glojnaric I. Cantharidin-induced inflammation in mouse ear model for translational research of novel anti-inflammatories. (fidelta.eu)
  • Moreover, there have also been studies into whether or not cantharidin could be effective at being used as an inflammatory model or in cancer treatment - either of which has yet to formally elucidate any results [ 2 ] . (drugbank.ca)
  • Anyone who has previously received treatment with cantharidin. (clinicaltrials.gov)
  • Treatment of human bladder cancer cells with cantharidin significantly decreased cell viability. (sigmaaldrich.com)
  • Importantly, cantharidin significantly decreased the tumor volume (a dramatic 71% reduction after 21 days of treatment) in nude mice xenografted with T24 cells. (sigmaaldrich.com)
  • Cantharidin was not found to be related to multidrug resistance phenotype, suggesting its potential usefulness for the treatment of refractory tumors. (biomedcentral.com)
  • Cantharidin is one of many natural products used in traditional Chinese medicine and traditional Vietnamese medicine for cancer treatment. (biomedcentral.com)
  • Cantharidin exhibited acute cytotoxicity in the T 24 cells, and IC 50 was 21.8, 11.2 and 4.6 μM after treatment for 6, 24 and 48 h, respectively. (elsevier.com)
  • Moreover, PARP proteins and pro-caspase 3, Bcl-2 were significantly inhibited after cantharidin treatment in T 24 cells. (elsevier.com)
  • Moreover, an increase in MPAO activity was observed in the same tissues upon cantharidin treatment. (usda.gov)
  • My old derm used to use cantharidin, worked well with little/no scarring and MC resolved in about 4 months completely. (dailystrength.org)
  • The increase in the expressions of caspase-3 activity and cleaved form of caspase-9/-7/-3 were also increased in cantharidin-treated T24 cells. (sigmaaldrich.com)
  • Cantharidin was capable of increasing the intracellular Ca (2+) and the phosphorylation of protein kinase C (PKC) in T24 cells. (sigmaaldrich.com)
  • In contrast, studies with double thymidine-synchronized populations of cells indicate that cantharidin can rapidly arrest growth when added during G 2 or early M phase. (aacrjournals.org)
  • A, effect of cantharidin ( inset ) on the divalent cation-independent phosphatase activity contained in a crude homogenate of A549 cells. (aacrjournals.org)
  • We also investigated the AhR-dependent activities of cantharidin and emodin (in herbal extracts) in Ah-responsive MCF-7 human breast cells, HepG2 human liver cancer cells, and mouse Hepa-1 cells transiently or stably transfected with plasmids expressing a luciferase reporter gene linked to multiple copies of a consensus dioxin-responsive element. (thefreedictionary.com)
  • The cytotoxicity of cantharidin was not significantly enhanced when T 24 cells were treated for a longer time. (elsevier.com)
  • When T 24 cells were treated with cantharidin at a low dose, the cell cycle was arrested in the G 2 /M phase. (elsevier.com)
  • At a high dose (more 12.5 μM), cantharidin could stimulate T 24 cells to deplete a large number of ATP and induce secondary necrosis. (elsevier.com)
  • In addition, cantharidin also stimulated COX 2 over-expression and PGE 2 production in T 24 cells, in a dose-dependent manner. (elsevier.com)