Cantharidin. Medical search

A toxic compound, isolated from the Spanish fly or blistering beetle (Lytta (Cantharis) vesicatoria) and other insects. It is a potent and specific inhibitor of protein phosphatases 1 (PP1) and 2A (PP2A). This compound can produce severe skin inflammation, and is extremely toxic if ingested orally.

INSECTS of the order Coleoptera, containing over 350,000 species in 150 families. They possess hard bodies and their mouthparts are adapted for chewing.

A specific inhibitor of phosphoserine/threonine protein phosphatase 1 and 2a. It is also a potent tumor promoter. (Thromb Res 1992;67(4):345-54 & Cancer Res 1993;53(2):239-41)

A group of enzymes removing the SERINE- or THREONINE-bound phosphate groups from a wide range of phosphoproteins, including a number of enzymes which have been phosphorylated under the action of a kinase. (Enzyme Nomenclature, 1992)

Sexual union of a male and a female in non-human species.

Most abundant proteins in COBRA venom; basic polypeptides of 57 to 62 amino acids with four disulfide bonds and a molecular weight of less than 7000; causes skeletal and cardiac muscle contraction, interferes with neuromuscular and ganglionic transmission, depolarizes nerve, muscle and blood cell membranes, thus causing hemolysis.

The protein phosphatase inhibitor cantharidin induces head and foot formation in buds of Cassiopea andromeda (Rhizostomae, Scyphozoa). (1/89)

The polyps of Cassiopea andromeda produce spindle shaped, freely swimming buds which do not develop a head (a mouth opening surrounded by tentacles) and a foot (a sticky plate at the opposite end) until settlement to a suited substrate. The buds, therewith, look very similar to the planula larvae produced in sexual reproduction. With respect to both, buds and planulae, several peptides and the phorbolester TPA have been found to induce the transformation into a polyp. Here it is shown that cantharidin, a serine/threonine protein phosphatase inhibitor, induces head and foot formation in buds very efficiently in a 30 min treatment, the shortest yet known efficient treatment. Some resultant polyps show malformations which indicate that a bud is ordinary polyp tissue in which preparatory steps of head and foot formation mutually block each other from proceeding. Various compounds related to the transfer of methyl groups have been shown to affect head and foot formation in larvae of the hydrozoon Hydractinia echinata. These compounds including methionine, homocysteine, trigonelline, nicotinic acid and cycloleucine are shown to also interfere with the initiation of the processes which finally lead to head and foot formation in buds of Cassiopea andromeda. (+info)

The protein phosphatase inhibitor cantharidin alters vascular endothelial cell permeability. (2/89)

In this study, we characterized the effects of the protein phosphatases type 1 (PP 1) and type 2A (PP 2A) inhibitor cantharidin in endothelial cells. We identified catalytic subunits of PP 1alpha, PP 2Aalpha, and PP 2Abeta immunologically in bovine aortic endothelial cells. Moreover, we detected mRNAs coding for catalytic subunits of PP 1alpha, PP 1beta, and PP 2Aalpha by hybridization with specific DNA probes in total RNA from these cells. Okadaic acid and cantharidin inhibited the activities of catalytic subunits of PP 1 (okadaic acid, 0.01-1 microM; cantharidin, 1-100 microM) and PP 2A (okadaic acid, 0.1 nM to 1 microM; cantharidin, 0.1-100 microM) separated by column chromatography in a concentration-dependent manner. Moreover, cantharidin (1 microM to 1 mM) increased the phosphorylation state of endothelial proteins including the regulatory light chains of myosin without affecting cytosolic calcium concentrations. Cantharidin (5-100 microM) increased the permeability of cultured endothelial cells in a time- and concentration-dependent manner. We suggest that inhibition of PP 1 and PP 2A activities by cantharidin increases endothelial permeability by enhancing the phosphorylation state of endothelial regulatory proteins. Thus, cantharidin might be a useful tool to study the function of protein phosphatases in endothelial barrier function. (+info)

Penetration of moxifloxacin into peripheral compartments in humans. (3/89)

To characterize the penetration of moxifloxacin (BAY 12-8039) into peripheral target sites, the present study aimed at measuring unbound moxifloxacin concentrations in the interstitial space fluid by means of microdialysis, an innovative clinical sampling technique. In addition, moxifloxacin concentrations were measured in cantharides-induced skin blisters, saliva, and capillary plasma and compared to total- and free-drug concentrations in venous plasma. For this purpose, 12 healthy volunteers received moxifloxacin in an open randomized crossover fashion either as a single oral dose of 400 mg or as a single intravenous infusion of 400 mg over 60 min. An almost-complete equilibration of the free unbound plasma fraction of moxifloxacin with the interstitial space fluid was observed, with mean area under the concentration-time curve (AUC)(interstitial fluid)/AUC(total-plasma) ratios ranging from 0.38 to 0.55 and mean AUC(interstitial fluid)/AUC(free-plasma) ratios ranging from 0.81 to 0.86. The skin blister concentration/plasma concentration ratio reached values above 1.5 after 24 h, indicating a preferential penetration of moxifloxacin into inflamed lesions. The moxifloxacin concentrations in saliva and capillary blood were similar to the corresponding levels in plasma. Our data show that moxifloxacin concentrations attained in the interstitial space fluid in humans and in skin blister fluid following single doses of 400 mg exceed the values for the MIC at which 90% of isolates are inhibited for most clinically relevant bacterial strains, notably including penicillin-resistant Streptococcus pneumoniae. These findings support the use of moxifloxacin for the treatment of soft tissue and respiratory tract infections in humans. (+info)

A study to determine the pharmacokinetics and inflammatory fluid penetration of gatifloxacin following a single oral dose. (4/89)

A single 400 mg oral dose of gatifloxacin was given to each of nine healthy male volunteers and the concentrations of the drug in plasma, cantharidine-induced inflammatory fluid and urine were measured over the following 24 h. The mean peak concentration in plasma of 4. 1 mg/L was attained at a mean time of 1.8 h post dose. The mean peak concentration in inflammatory fluid was 3.6 mg/L and was attained at a mean time of 4.2 h post dose. The mean plasma elimination half-life of gatifloxacin was 6.8 h and that in inflammatory fluid was 7.2 h. The mean penetration into the inflammatory fluid was 117%. Recovery of drug from urine during the first 24 h post dose was 65% of that administered. Our data suggest that gatifloxacin dosed at 400 mg od should be adequate to treat systemic infections caused by most bacterial species. (+info)

Phosphatase inhibitor cantharidin blocks adenosine A(1) receptor anti-adrenergic effect in rat cardiac myocytes. (5/89)

Experiments were performed to examine whether the protein phosphatase inhibitor cantharidin blocks the anti-adrenergic effect of adenosine A(1) receptor stimulation. In electrically stimulated adult rat ventricular myocytes loaded with the intracellular calcium concentration ([Ca(2+)](i)) indicator fluo-3, isoproterenol (10 nM) increased systolic [Ca(2+)](i) by 46%, increased twitch amplitude by 56%, and increased total cellular cAMP content by 140%. The adenosine A(1) receptor agonist 2-chloro-N(6)-cyclopentlyadenosine (CCPA) reduced isoproterenol-stimulated [Ca(2+)](i) and contractility by 87 and 80%, respectively, but reduced cAMP content by only 18%. Cantharidin had no effects on myocyte [Ca(2+)](i), contractility, or cAMP in the absence or presence of isoproterenol but blocked the effects of CCPA on [Ca(2+)](i) and contractility by approximately 44%. Cantharidin had no effect on CCPA attenuation of isoproterenol-induced increases in cAMP. Pretreatment with CCPA also reduced the increase in contractile parameters produced by the direct cAMP-dependent protein kinase A (PKA) activator 8-bromocAMP. These results suggest that activation of protein phosphatases mediate, in part, the anti-adrenergic effect of adenosine A(1) receptor activation in ventricular myocardium. (+info)

Hamster pancreatic beta cell lines with altered sensitivity towards apoptotic signalling by phosphatase inhibitors. (6/89)

Specific inhibitors of serine/threonine phosphatases like okadaic acid can induce apoptotic cell death in the pancreatic beta cell line HIT. Cultivation in stepwise increased concentrations of okadaic acid enabled the isolation of HIT100R cells which proliferate at 100 nM okadaic acid (8 - 10 times the initially lethal concentration). These two cell lines were used to characterize the events triggered by okadaic acid that led to apoptosis. Biochemical markers, e.g. cytochrome c release from mitochondria and increase of caspase-3-like activity, revealed that induction of apoptosis by 100 nM okadaic acid in parental HIT cells started with the release of cytochrome c. In HIT100R cells 500 nM okadaic acid were necessary to induce alterations comparable to those observed with 100 nM okadaic acid in non-resistant HIT cells. In contrast to okadaic acid, the potency of the structurally different phosphatase inhibitor cantharidic acid to induce cytochrome c release, increase of caspase-3-like activity and DNA fragmentation was comparable in HIT and HIT100R cells. Thus, no cross-resistance between these phosphatase inhibitors seemed to exist. Phosphatase activity in extracts from HIT and HIT100R cells did not differ in its total amount or in its sensitivity for okadaic acid. Since higher concentrations of okadaic acid were needed to induce apoptosis in HIT100R cells, a compromised intracellular accumulation of the toxin appeared likely. Functional and structural analysis revealed that this was achieved by the development of the multidrug resistance phenotype in HIT100R cells. The underlying mechanism appeared to be the enhanced expression of the pgp1 but not the pgp2 gene. (+info)

Protein phosphatase inhibitors arrest cell cycle and reduce branching morphogenesis in fetal rat lung cultures. (7/89)

Protein phosphatase 2A (PP2A) is a key signal transduction intermediate in the regulation of cellular proliferation and differentiation in vitro. However, the role of PP2A in the context of a developing organ is unknown. To explore the role of PP2A in the regulation of lung development, we studied the effect of PP2A inhibition on new airway branching, induction of apoptosis, DNA synthesis, and expression of epithelial marker genes in whole organ explant cultures of embryonic (E14) rat lung. Microdissected lung primordia were cultured in medium containing one of either two PP2A inhibitors, okadaic acid (OA, 0-9 nM) or cantharidin (Can, 0-3,600 nM), or with the PP2B inhibitor deltamethrin (Del, 0-10 microM) as a control for a PP2A-specific effect for 48 h. PP2A inhibition with OA and Can significantly inhibited airway branching and overall lung growth. PP2B inhibition with Del did not affect lung growth or new airway development. Histologically, both PP2A- and PP2B-inhibited explants were similar to controls. Increased apoptosis was not the mechanism of decreased lung growth and new airway branching inasmuch as OA-treated explant sections subjected to the terminal deoxynucleotidyltransferase dUTP nick end labeling reaction demonstrated a decrease in apoptosis. However, PP2A inhibition with OA increased DNA content and 5-bromo-2'-deoxyuridine uptake that correlated with a G(2)/M cell cycle arrest. PP2A inhibition also resulted in altered differentiation of the respiratory epithelium as evidenced by decreased mRNA levels of the early epithelial marker surfactant protein C. These findings suggest that inhibition of protein phosphatases with OA and Can halted mesenchymal cell cycle progression and reduced branching morphogenesis in fetal rat lung explant culture. (+info)

Cantharidin enhances norepinephrine-induced vasoconstriction in an endothelium-dependent fashion. (8/89)

In this study we characterized the effects of the protein phosphatase (PP) type 1 and type 2A inhibitor cantharidin (Cant) and its structural analogs cantharidic acid and endothall on PP activity, force of contraction, and myosin light chain phosphorylation in rat aorta. All compounds inhibited PP activity in homogenates of rat aorta with a rank order of potency of Cant = cantharidic acid > endothall. However, only Cant increased force of contraction and myosin light chain phosphorylation in intact isolated rat aortic rings. Based on these findings, we investigated the effects of Cant on alpha-adrenoceptor-mediated vasoconstriction. Cant (1 and 3 microM) enhanced norepinephrine-induced contraction in endothelium-intact rat aorta. In contrast, Cant did not affect norepinephrine-induced contraction in endothelium-denuded rat aorta. We suggest that inhibition of PP1 and/or PP2A activities by Cant enhances vascular contractility in endothelium-intact rat aorta by increasing the phosphorylation state of endothelial regulatory proteins. (+info)

Cantharidin is a toxic alkaloid found in certain species of blister beetles, such as the Spanish fly. It is known for its powerful irritant and vesicant properties, causing severe blistering and inflammation of the skin and mucous membranes upon contact. In the medical field, cantharidin is sometimes used as a topical treatment for warts and other skin growths. However, it is highly toxic and can cause serious side effects, including nausea, vomiting, diarrhea, abdominal pain, and even death in high doses. Therefore, its use is generally restricted to medical professionals and requires careful monitoring and dosage control.

In the medical field, beetles are not typically studied or used for medical purposes. Beetles are a type of insect that belong to the order Coleoptera, which is the largest order of insects. They are known for their hard exoskeletons, which protect their internal organs. However, some species of beetles are used in medical research for their potential as sources of new drugs or as models for studying human diseases. For example, the beetle species Tribolium castaneum has been used in research on aging and cancer, while the beetle species Tenebrio molitor is used in the production of silkworms and has been studied for its potential as a source of therapeutic compounds. In general, beetles are not commonly associated with medical treatments or interventions, but their unique biological characteristics and potential applications in research make them an interesting subject of study for scientists.

Okadaic acid is a potent marine toxin produced by certain species of dinoflagellates, which are microscopic algae found in marine environments. It is a member of a group of toxins called polyether lipids, which are also known as diarrhetic shellfish poisoning (DSP) toxins. In the medical field, okadaic acid is primarily associated with seafood poisoning, which can occur when contaminated shellfish are consumed. The symptoms of okadaic acid poisoning can include nausea, vomiting, diarrhea, abdominal pain, and fever. In severe cases, it can lead to liver damage, kidney failure, and even death. Okadaic acid is also being studied for its potential therapeutic uses. Some research has suggested that it may have anti-cancer properties and may be useful in the treatment of certain types of cancer. However, more research is needed to confirm these findings and to determine the safety and efficacy of okadaic acid as a cancer treatment.

Phosphoprotein phosphatases are enzymes that remove phosphate groups from phosphoproteins, which are proteins that have been modified by the addition of a phosphate group. These enzymes play a crucial role in regulating cellular signaling pathways by modulating the activity of phosphoproteins. There are several types of phosphoprotein phosphatases, including protein tyrosine phosphatases (PTPs), protein serine/threonine phosphatases (S/T phosphatases), and phosphatases that can dephosphorylate both tyrosine and serine/threonine residues. Phosphoprotein phosphatases are involved in a wide range of cellular processes, including cell growth and division, metabolism, and immune response. Dysregulation of phosphoprotein phosphatase activity has been implicated in various diseases, including cancer, diabetes, and neurodegenerative disorders.

In the medical field, copulation refers to the sexual act of penetration between a male and female reproductive organ, typically involving intercourse. It is a common form of sexual activity and is often associated with reproduction, although it can also occur for pleasure or other reasons. Copulation typically involves the penis penetrating the vagina, although other forms of sexual activity, such as anal or oral sex, can also occur. It is important to note that copulation can carry risks, including the transmission of sexually transmitted infections (STIs) and unwanted pregnancies, and it is important to practice safe sex to minimize these risks.

Cobra cardiotoxin proteins are a type of venom found in certain species of cobras, such as the Indian cobra and the king cobra. These proteins are known to be potent toxins that can cause damage to the heart muscle and lead to cardiac arrest. When a cobra injects its venom into a victim, the cardiotoxin proteins can interfere with the normal functioning of the heart's electrical system, leading to abnormal heart rhythms and potentially causing the heart to stop beating altogether. This can be a life-threatening condition, and prompt medical attention is necessary to prevent serious complications. In addition to their effects on the heart, cobra cardiotoxin proteins have also been shown to have other biological effects, such as causing inflammation and disrupting the normal functioning of nerve cells. As a result, these toxins have been the subject of extensive research in the fields of pharmacology and toxicology, with the goal of developing new treatments for a variety of medical conditions.

... and soldier beetles also produce cantharidin. "Ycanth- cantharidin solution". DailyMed. 25 July 2023. Archived from the ... The level of cantharidin in blister beetles can be quite variable. Among blister beetles of the genus Epicauta in Colorado, E. ... Diluted solutions of cantharidin can be used as a topical medication to remove warts and tattoos, and to treat the small ... Cantharidin was first isolated as a chemically pure substance in 1810 by Pierre Robiquet, a French chemist then living in Paris ...

https://en.wikipedia.org/wiki/Cantharidin

Karras, DJ; Farrell SE, Harrigan RA, Henretig FM, Gealt L (September 14, 1996). "Poisoning from 'Spanish fly' (cantharidin)". ... PMID 8765116.{{cite journal}}: CS1 maint: multiple names: authors list (link) Lewis, Robert Alan (1998). "Cantharidin; ... Cantharidin poisoning". Lewis' Dictionary of Toxicology. CRC Press. p. 222. ISBN 978-0849363177. Inglis, Esther (February 12, ...

https://en.wikipedia.org/wiki/It's_True!_It's_True!

... Intoxication: Cantharidin Poisoning meloidae.com blister beetles UF / IFAS Featured Creatures striped blister ... Blister beetles are beetles of the family Meloidae, so called for their defensive secretion of a blistering agent, cantharidin ... In semiarid areas of the western United States, modern harvesting techniques may contribute to cantharidin content in harvested ... Cantharidin, a poisonous chemical that causes blistering of the skin, is secreted as a defensive agent. It is used medically to ...

https://en.wikipedia.org/wiki/Blister_beetle

It is an economically important species due to the ability to biosynthesize potent defensive blistering agent cantharidin. Seen ... Till, Jonathan S.; Majmudar, Bhagirath N. (April 1981). "Cantharidin Poisoning". Southern Medical Journal. 74 (4): 444-447. doi ...

https://en.wikipedia.org/wiki/Hycleus_pustulatus

Nakatani, T.; Konishi, T.; Miyahara, K.; Noda, N. (2004). "Three novel cantharidin-related compounds from the Chinese blister ... Till, Jonathan S.; Majmudar, Bhagirath N. (April 1981). "Cantharidin Poisoning". Southern Medical Journal. 74 (4): 444-447. doi ... "Four new cantharidin derivatives from the Chinese blister beetles, Mylabris phalerata". Heterocycles. 94 (8): 1573-1581. doi: ... due to the ability to biosynthesize potent defensive blistering agent cantharidin. The beetle was traditionally used to treat ...

https://en.wikipedia.org/wiki/Hycleus_phaleratus

Dauben, W. G.; Kessel, C. R.; Takemura, K. H. (1980). "Simple, efficient total synthesis of cantharidin via a high-pressure ... Mitteilung: Über Cantharidin". Berichte der Deutschen Chemischen Gesellschaft. 62 (3): 554-562. doi:10.1002/cber.19290620318. ...

https://en.wikipedia.org/wiki/Diels–Alder_reaction

"A New Source of Santonin" (1922, with Arno Viehoever) "Domestic Sources of Cantharidin" (1923, with Arno Viehoever) "Mineral ... Viehoever, Arno; Capen, Ruth G. (1923). "Domestic Sources of Cantharidin". Journal of the Association of Official Analytical ...

https://en.wikipedia.org/wiki/Ruth_G._Capen

They contain the blister agent cantharidin. Powdered centipede (wu gong) is believed under TCM to treat tetanus, seizures, ...

https://en.wikipedia.org/wiki/List_of_traditional_Chinese_medicines

Cantharidin, the active agent, is a terpenoid, and is produced by some other insects, such as Epicauta immaculata. Cantharidin ... Currently the cantharidin in US, in the form of collodion, is used in the treatment of warts and molluscum. In Morocco and ... The defensive chemical cantharidin, for which the beetle is known, is synthesised only by males; females obtain it from males ... Cantharidin, the principal active component in preparations of Spanish fly, was first isolated and named in 1810 by the French ...

https://en.wikipedia.org/wiki/Spanish_fly

Li, YM; Casida, JE (15 December 1992). "Cantharidin-binding protein: identification as protein phosphatase 2A". Proceedings of ... Endothall is chemically related to cantharidin. Both compounds are protein phosphatase 2A inhibitors. Protein phosphatase ... "Insights into the key interactions between human protein phosphatase 5 and cantharidin using molecular dynamics and site- ...

https://en.wikipedia.org/wiki/Endothall

Blister beetles (family Meloidae) contain a compound called cantharidin, which causes blistering. The blister beetles can be ... Pfeifer, Mallory (2020-03-12). "Diagnostic guidance: Cantharidin poisoning in horses". Texas A&M Veterinary Medical Diagnostic ... "Male Accessory Glands of Blister Beetles and Cantharidin Release: A Comparative Ultrastructural Analysis". Insects. 13 (2): 132 ...

https://en.wikipedia.org/wiki/Economic_entomology

It is the hydrolysis product of cantharidin. "Cantharidic Acid , CAS 28874-45-5". Azoulay-Alfaguter I, Strazza M, Peled M, ...

https://en.wikipedia.org/wiki/Cantharidic_acid

The cantharidin acts as a feeding toxin and renders the eggs unpalatable to predators; females therefore prefer males with a ... Eiden, Fritz (2006). "Cantharidin: Hochzeitsgabe, Schutz- und Lockstoff, Blasenzieher und Enzymhemmer". Chemie in unserer Zeit ... Karl Ziegler and Günther Otto Schenck succeeded in synthesizing cantharidin as early as 1941. The preparation of pheromones ... Polettini, A.; Crippa, O.; Ravagli, A.; Saragoni, A. (1992). "A fatal case of poisoning with cantharidin". Forensic Science ...

https://en.wikipedia.org/wiki/Insect_pheromones

Cantharidin is an unreliable and dangerous aphrodisiac. Its impact is primarily based totally on stimulation of the urogenital ... The aphrodisiac effect has not been clinically tested and is achieved by cantharidin inhibition of phosphodiesterase, protein ...

https://en.wikipedia.org/wiki/Korean_bug

Crushing the beetle also releases the cantharidin. Cantharidin is a poisonous substance which can prove fatal if ingested. The ... In Tegrodera aloga, cantharidin is excreted through the leg joints and the antennal pores. It is toxic to humans and can ... The brightness of the spots warns of the cantharidin toxins the beetle carries; this coloration is known as aposematism, and it ... Ghoneim, Karem S. (2013). "Human dermatosis caused by vesicating beetle products (Insecta), cantharidin and paederin: An ...

https://en.wikipedia.org/wiki/Tegrodera_aloga

Cantharidin toxicity in an animal may be called cantharidiasis. The cantharidin content of one striped blister beetle has been ... DiFonzo, C. Cantharidin content and lethal dose of common Michigan blister beetles. Archived 2016-03-04 at the Wayback Machine ... The toxic dose of cantharidin in horses is about one milligram per kilogram body weight, and the ingestion of 30 to 50 beetles ... Like other blister beetles, it contains cantharidin, a toxic terpenoid. This compound is a vesicant that causes the blistering ...

https://en.wikipedia.org/wiki/Epicauta_vittata

Studies have found cantharidin to be an effective and safe treatment for removing molluscum contagiosum. This medication is ... Torbeck R, Pan M, DeMoll E, Levitt J (June 2014). "Cantharidin: a comprehensive review of the clinical literature". Dermatology ...

https://en.wikipedia.org/wiki/Molluscum_contagiosum

During his residency, his semiology skills led to his first scientific report in the U.S. - recognition of cantharidin ... Wertelecki, Wladimir; Vietti, Teresa J.; Kulapongs, Panja (1967-02-01). "Cantharidin Poisoning from Ingestion of a "Blister ...

https://en.wikipedia.org/wiki/Wladimir_Wertelecki

Cantharidin is used to treat warts that are resistant to other treatment, and although not well-researched it is sufficiently ... Cantharidin is toxic to vertebrates, the aposematic colouration of the beetles being a clear warning. Symptoms of poisoning ... In the late 1700s the Marquis de Sade was charged with poisoning of participants in an orgy by the use of cantharidin. ... Horses are particularly susceptible to cantharidin poisoning and may die from eating dry hay or when grazing on alfalfa or ...

https://en.wikipedia.org/wiki/Ceroctis_capensis

The synthesis of cantharidin]. Justus Liebig's Annalen der Chemie. 551: 1-79. doi:10.1002/jlac.19425510102. Binkley, R. W.; ...

https://en.wikipedia.org/wiki/N-Bromosuccinimide

Mating then occurs, with the male transferring his cantharidin to the female during this period and she coats her eggs with it ... This defensive strategy is not exclusive to this genus; all meloids possess and exude cantharidin upon threat. Members of this ... This fluid is bright orange and contains cantharidin, a poisonous chemical compound. Wiping the chemical on skin can cause ...

https://en.wikipedia.org/wiki/Meloe

Cantharidin can kill a great bustard if many beetles are ingested. Self-medication could have evolved in great bustards as a ... Male great bustards may use the highly toxic cantharidin taken from blister beetles of the genus Meloe to clean their intestine ... Sánchez-Barbudo, I. S.; Camarero, P.; García-Montijano, M.; Mateo, R. (2012). "Possible cantharidin poisoning of a great ...

https://en.wikipedia.org/wiki/Sexual_selection_in_birds

Great bustards eat blister beetles of the genus Meloe maybe to decrease parasite load in the digestive system; cantharidin, the ... Sánchez-Barbudo, I. S.; Camarero, P. R.; García-Montijano, M.; Mateo, R. (2012). "Possible cantharidin poisoning of a great ...

https://en.wikipedia.org/wiki/Zoopharmacognosy

Sweating was also induced using blisters of cantharidin and diaphoretic. Heroic medicine became less favoured with the rise of ... He was bled repeatedly and given Mercury(I) chloride (calomel) and several blisters of cantharidin to induce sweating. ...

https://en.wikipedia.org/wiki/Heroic_medicine

Chobaut was among the first to note the attraction of anthicids to meloids, suggesting that cantharidin might play a role. He ... Young, Daniel K. (1984). "Cantharidin and Insects: An Historical ReviewCantharidin and Insects: An Historical Review". The ...

https://en.wikipedia.org/wiki/Alfred_Chobaut

The poison, cantharidin, is held within the tissue of the bird resulting in poisoning of those that eat the cooked goose. A ... dose of 10 mg of cantharidin can kill a human. This species often occurs in open grasslands with lakes, seasonal pools, rivers ...

https://en.wikipedia.org/wiki/Spur-winged_goose

The blister beetle is known to distribute a toxin known as cantharidin. This toxin if ingested can cause severe ...

https://en.wikipedia.org/wiki/Equine_exertional_rhabdomyolysis

Jiang M, Lü S, Zhang Y (May 2017). "Characterization of Juvenile Hormone Related Genes Regulating Cantharidin Biosynthesis in ...

https://en.wikipedia.org/wiki/Juvenile_hormone_acid_O-methyltransferase

Adults rarely eat but have been known to be attracted to cantharidin. "Neopyrochroa flabellata (Fabricius, 1787)". GBIF. " ...

https://en.wikipedia.org/wiki/Neopyrochroa_flabellata

DiFonzo, C. Cantharidin content and lethal dose of common Michigan blister beetles. Archived 2016-03-04 at the Wayback Machine ... As do other blister beetles, these produce cantharidin, a toxic terpenoid which can kill animals such as horses if they ingest ...

https://en.wikipedia.org/wiki/Epicauta

Cantharidin Topical: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Cantharidin is in a class of medications called vesicants. It is not known exactly how cantharidin works to treat molluscum ... Before using topical cantharidin,. *tell your doctor and pharmacist if you are allergic to cantharidin, any other medications, ... Topical cantharidin may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away: *lightening ...

https://medlineplus.gov/druginfo/meds/a623044.html

https://en.wikipedia.org/wiki/Cantharidin

Topical cantharidin showed high efficacy and safety for the treatment of warts, especially when used with podophyllotoxin and ... Topical Cantharidin Safe and Effective for Warts and Molluscum Contagiosum. Dermatology Advisor Contributing Writer ... Cantharidin therapy was reported to be well tolerated, with minor adverse events that included pain (7% to 85.7%), blistering ( ... Topical cantharidin showed high efficacy and safety for the treatment of warts, especially when used with podophyllotoxin and ...

https://www.dermatologyadvisor.com/home/topics/general-dermatology/topical-cantharidin-safe-and-effective-for-warts-and-molluscum-contagiosum/

Cantharidin has the potential to be harmful to pets, particularly if ingested. Symptoms of cantharidin poisoning in pets ... Cantharidin is commercially known as Spanish Fly." Letter 16 - Oil Beetle. Subject: Blue beetle?. Geographic location of the ... Cantharidin and Blisters. Oil beetles, also known as blister beetles, belong to the family Meloidae. When disturbed or squeezed ... This oil contains cantharidin, an irritating chemical that, when in contact with human skin, can cause blistering in many ...

https://www.whatsthatbug.com/are-oil-beetles-dangerous/

Zhang, X.; Lin, C.-C.; Chan, W.-K.-N.; Liu, K.-L.; Yang, Z.-J.; Zhang, H.-Q. Augmented Anticancer Effects of Cantharidin with ... Finally, liposomal formulations like cantharidin-PEG-liposomes [81] or CUR-glycyrrhetinic acid-cationic liposomes [82] have ...

https://www.mdpi.com/2079-4991/9/4/638

Monoterpenes contain 2 isoprene units; examples include cantharidin, menthol, pinene, and camphor. [1] Diterpenes contain 4 ...

https://emedicine.medscape.com/article/818675-overview

Spanish Fly, Cantharidin, Canth.. Available in 4X-30X, 4C-30C, 200C, 1M-10M from $8.29. Purchase options. ...

https://abchomeopathy.com/r.php/Canth/mouth/

The development of ring warts is a known complication associated with cantharidin use, with little described rationale to the ... circumferentially spread from the initial site after first-line treatment and presumed resolution with the product cantharidin ...

https://japmaonline.org/search?access=all&page=23&pageSize=10&q=%22infection%22&sort=relevance

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https://edrugsearch.com/drug-prices/cantharidin-acetylsalicylic-acid-podophyllin-costs-coupons/

S-AdoMet-dependent methyltransferase involved in lipid homeostasis; mediates resistance to a drug cantharidin ...

https://thebiogrid.org/36643/protein

Other options for topical therapy include iodine and salicylic acid, potassium hydroxide, tretinoin, cantharidin (a blistering ...

https://www.cdc.gov/poxvirus/molluscum-contagiosum/treatment.html

Cantharidin (LC/MS). Detection of cantharidin, the toxic chemical produced by blister beetles, by liquid chromatography/mass ...

https://tvmdl.tamu.edu/species/camelid/?orderby=title&viewall=1&order=ASC

Wart removal is performed by applying medications like salicylic acid or cantharidin onto the wart. Cryosurgery, by freezing ...

https://www.whatclinic.com/dermatology/uk/merseyside/wart-removal

... which contain the potent toxins cantharidin. These birds could be self-medicating by occasional beetle-eating, perhaps reducing ...

https://www.juneauempire.com/news/on-the-trails-toxic-birds-and-bugs/

If cantharidin comes into contact with the cornea, it can cause scarring. Cantharidin should be washed off with soap and water ... Cantharidin is safe and effective but can cause blistering. It is applied in 1 small drop directly to the molluscum lesion. ... Cantharidin should not be applied to the face or near the eyes because blistering is unpredictable. ... Dermatologists often use combination therapy such as liquid nitrogen or cantharidin in the office or a retinoid cream at home. ...

https://www.msdmanuals.com/professional/dermatologic-disorders/viral-skin-diseases/molluscum-contagiosum

CANTHARIDIN 50865 CAPREOMYCIN 50866 CAPRYLIC ACID 50867 CAPSAICIN 50868 CAPSICUM 50869 CAPTOPRIL 50870 CARAMEL 50873 CARAMIPHEN ...

https://wonder.cdc.gov/wonder/sci_data/surveys/namcs/type_txt/namcs94.asp

If Approved, Cantharidin 0.7% Could be Standard of Molluscum Care. October 21st 2021. ...

https://www.dermatologytimes.com/authors/lisette-hilton

Depending on the size and location of the wart and the stoicism of the child, I sometimes use cantharidin, but frequently I use ...

https://www.contemporarypediatrics.com/view/best-tech-pediatrics-2016

Cantharidin, as chemotherapy for warts, Cimetidine, as chemotherapy for warts, Deoxy-D-glucose, as chemotherapy for warts, ...

https://ijpc.com/abstracts/abstract.cfm?ABS=1721

Cantharone Plus (Cantharidin Plus) 1+2+30% * B Carafate (Sucralfate) Suspension 1gm/5ml ...

https://www.canadacloudpharmacy.com/onlineprescriptions/85?alpha=C

The man says that the doctor he saw began to treat the wart with cantharidin, an agent made from a beetle that causes the area ...

https://rightwingnews.com/health/warning-do-not-walk-barefoot-at-the-gym-this-could-be-you-photos/

Horses with cantharidin toxicosis develop colic, decreased appetite, depression and sweating, blood in the urine, dark mucous ... They contain a chemical called cantharidin that is extremely toxic to horses. The Texas Veterinary Medical Diagnostic Lab ...

https://veterinarypartner.vin.com/default.aspx?pid=19239&meta=1iv&catId=102906&id=4952855&ind=1118&objTypeID=1007

CANTHARIDIN; PODOPHYLLUM RESIN TOPICAL; SALICYLIC ACID TOPICAL a10159=CASEIN; COCONUT OIL; CORN OIL; MULTIVITAMIN; SUCROSE ...

https://ftp.cdc.gov/pub/Health_Statistics/NCHS/Datasets/NHHCS/2007/Text_ASCII/SAS_Input_Statements/NHHCS07MEDFORMATS.txt