Canrenone: A synthetic pregnadiene compound with anti-aldosterone activity.Canrenoic Acid: A synthetic pregnadiene derivative with anti-aldosterone activity.Pregnadienes: Pregnane derivatives containing two double bonds anywhere within the ring structures.Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)Mineralocorticoid Receptor Antagonists: Drugs that bind to and block the activation of MINERALOCORTICOID RECEPTORS by MINERALOCORTICOIDS such as ALDOSTERONE.Hymecromone: A coumarin derivative possessing properties as a spasmolytic, choleretic and light-protective agent. It is also used in ANALYTICAL CHEMISTRY TECHNIQUES for the determination of NITRIC ACID.Administration, Intravenous: Delivery of substances through VENIPUNCTURE into the VEINS.Ziziphus: A plant genus of the family RHAMNACEAE. Members contain nummularogenin (a spirostane) and is the source of an edible fruit.Seeds: The encapsulated embryos of flowering plants. They are used as is or for animal feed because of the high content of concentrated nutrients like starches, proteins, and fats. Rapeseed, cottonseed, and sunflower seed are also produced for the oils (fats) they yield.Plant Oils: Oils derived from plants or plant products.China: A country spanning from central Asia to the Pacific Ocean.Oils: Unctuous combustible substances that are liquid or easily liquefiable on warming, and are soluble in ether but insoluble in water. Such substances, depending on their origin, are classified as animal, mineral, or vegetable oils. Depending on their behavior on heating, they are volatile or fixed. (Dorland, 28th ed)Sulfonic Acids: Inorganic or organic oxy acids of sulfur which contain the RSO2(OH) radical.Oils, Volatile: Oils which evaporate readily. The volatile oils occur in aromatic plants, to which they give odor and other characteristics. Most volatile oils consist of a mixture of two or more TERPENES or of a mixture of an eleoptene (the more volatile constituent of a volatile oil) with a stearopten (the more solid constituent). The synonym essential oils refers to the essence of a plant, as its perfume or scent, and not to its indispensability.Sarcoma, Endometrial Stromal: A highly malignant subset of neoplasms arising from the endometrial stroma. Tumors in this group infiltrate the stroma with a wide range of atypia cells and numerous mitoses. They are capable of widespread metastases (NEOPLASM METASTASIS).Hydrochlorothiazide: A thiazide diuretic often considered the prototypical member of this class. It reduces the reabsorption of electrolytes from the renal tubules. This results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium. It is used in the treatment of several disorders including edema, hypertension, diabetes insipidus, and hypoparathyroidism.Adenoma: A benign epithelial tumor with a glandular organization.Leydig Cell Tumor: Gonadal interstitial or stromal cell neoplasm composed of only LEYDIG CELLS. These tumors may produce one or more of the steroid hormones such as ANDROGENS; ESTROGENS; and CORTICOSTEROIDS. Clinical symptoms include testicular swelling, GYNECOMASTIA, sexual precocity in children, or virilization (VIRILISM) in females.Adenoma, Liver Cell: A benign epithelial tumor of the LIVER.Leydig Cells: Steroid-producing cells in the interstitial tissue of the TESTIS. They are under the regulation of PITUITARY HORMONES; LUTEINIZING HORMONE; or interstitial cell-stimulating hormone. TESTOSTERONE is the major androgen (ANDROGENS) produced.Athletic Performance: Carrying out of specific physical routines or procedures by one who is trained or skilled in physical activity. Performance is influenced by a combination of physiological, psychological, and socio-cultural factors.Great Lakes Region: The geographic area of the Great Lakes in general and when the specific state or states are not indicated. It usually includes Illinois, Indiana, Michigan, Minnesota, New York, Ohio, Pennsylvania, and Wisconsin.Eicosapentaenoic Acid: Important polyunsaturated fatty acid found in fish oils. It serves as the precursor for the prostaglandin-3 and thromboxane-3 families. A diet rich in eicosapentaenoic acid lowers serum lipid concentration, reduces incidence of cardiovascular disorders, prevents platelet aggregation, and inhibits arachidonic acid conversion into the thromboxane-2 and prostaglandin-2 families.Fishes: A group of cold-blooded, aquatic vertebrates having gills, fins, a cartilaginous or bony endoskeleton, and elongated bodies covered with scales.Hindlimb Suspension: Technique for limiting use, activity, or movement by immobilizing or restraining animal by suspending from hindlimbs or tails. This immobilization is used to simulate some effects of reduced gravity and study weightlessness physiology.Doping in Sports: Illegitimate use of substances for a desired effect in competitive sports. It includes humans and animals.Sports Medicine: The field of medicine concerned with physical fitness and the diagnosis and treatment of injuries sustained in exercise and sports activities.Drug Industry: That segment of commercial enterprise devoted to the design, development, and manufacture of chemical products for use in the diagnosis and treatment of disease, disability, or other dysfunction, or to improve function.Bees: Insect members of the superfamily Apoidea, found almost everywhere, particularly on flowers. About 3500 species occur in North America. They differ from most WASPS in that their young are fed honey and pollen rather than animal food.Biotechnology: Body of knowledge related to the use of organisms, cells or cell-derived constituents for the purpose of developing products which are technically, scientifically and clinically useful. Alteration of biologic function at the molecular level (i.e., GENETIC ENGINEERING) is a central focus; laboratory methods used include TRANSFECTION and CLONING technologies, sequence and structure analysis algorithms, computer databases, and gene and protein structure function analysis and prediction.Outsourced Services: Organizational activities previously performed internally that are provided by external agents.Crops, Agricultural: Cultivated plants or agricultural produce such as grain, vegetables, or fruit. (From American Heritage Dictionary, 1982)Gift Giving: The bestowing of tangible or intangible benefits, voluntarily and usually without expectation of anything in return. However, gift giving may be motivated by feelings of ALTRUISM or gratitude, by a sense of obligation, or by the hope of receiving something in return.Commerce: The interchange of goods or commodities, especially on a large scale, between different countries or between populations within the same country. It includes trade (the buying, selling, or exchanging of commodities, whether wholesale or retail) and business (the purchase and sale of goods to make a profit). (From Random House Unabridged Dictionary, 2d ed, p411, p2005 & p283)Drug Users: People who take drugs for a non-therapeutic or non-medical effect. The drugs may be legal or illegal, but their use often results in adverse medical, legal, or social consequences for the users.Work: Productive or purposeful activities.Efficiency: Ratio of output to effort, or the ratio of effort produced to energy expended.Myiasis: The invasion of living tissues of man and other mammals by dipterous larvae.Genetic Code: The meaning ascribed to the BASE SEQUENCE with respect to how it is translated into AMINO ACID SEQUENCE. The start, stop, and order of amino acids of a protein is specified by consecutive triplets of nucleotides called codons (CODON).Work Capacity Evaluation: Assessment of physiological capacities in relation to job requirements. It is usually done by measuring certain physiological (e.g., circulatory and respiratory) variables during a gradually increasing workload until specific limitations occur with respect to those variables.Lighting: The illumination of an environment and the arrangement of lights to achieve an effect or optimal visibility. Its application is in domestic or in public settings and in medical and non-medical environments.Pit and Fissure Sealants: Agents used to occlude dental enamel pits and fissures in the prevention of dental caries.Adhesives: Substances that cause the adherence of two surfaces. They include glues (properly collagen-derived adhesives), mucilages, sticky pastes, gums, resins, or latex.Tissue Adhesives: Substances used to cause adherence of tissue to tissue or tissue to non-tissue surfaces, as for prostheses.Fibrin Tissue Adhesive: An autologous or commercial tissue adhesive containing FIBRINOGEN and THROMBIN. The commercial product is a two component system from human plasma that contains more than fibrinogen and thrombin. The first component contains highly concentrated fibrinogen, FACTOR VIII, fibronectin, and traces of other plasma proteins. The second component contains thrombin, calcium chloride, and antifibrinolytic agents such as APROTININ. Mixing of the two components promotes BLOOD CLOTTING and the formation and cross-linking of fibrin. The tissue adhesive is used for tissue sealing, HEMOSTASIS, and WOUND HEALING.Governing Board: The group in which legal authority is vested for the control of health-related institutions and organizations.GermanyLabor, Obstetric: The repetitive uterine contraction during childbirth which is associated with the progressive dilation of the uterine cervix (CERVIX UTERI). Successful labor results in the expulsion of the FETUS and PLACENTA. Obstetric labor can be spontaneous or induced (LABOR, INDUCED).Labor, Induced: Artificially induced UTERINE CONTRACTION. Generally, LABOR, OBSTETRIC is induced with the intent to cause delivery of the fetus and termination of pregnancy.Labor Onset: The beginning of true OBSTETRIC LABOR which is characterized by the cyclic uterine contractions of increasing frequency, duration, and strength causing CERVICAL DILATATION to begin (LABOR STAGE, FIRST ).Labor Pain: Pain associated with OBSTETRIC LABOR in CHILDBIRTH. It is caused primarily by UTERINE CONTRACTION as well as pressure on the CERVIX; BLADDER; and the GASTROINTESTINAL TRACT. Labor pain mostly occurs in the ABDOMEN; the GROIN; and the BACK.Obstetric Labor, Premature: Onset of OBSTETRIC LABOR before term (TERM BIRTH) but usually after the FETUS has become viable. In humans, it occurs sometime during the 29th through 38th week of PREGNANCY. TOCOLYSIS inhibits premature labor and can prevent the BIRTH of premature infants (INFANT, PREMATURE).Podospora: A genus of ascomycete FUNGI in the order SORDARIALES, which is found on SOIL and herbivore dung (FECES).

Assay and properties of 18-hydroxylation of endogenous and exogenous corticosterone in rat adrenals. Evidence for heterogeneity of 18-hydroxylase activity. (1/19)

A mass fragmentographic technique for assay of 18-hydroxylation of labeled (exogenous) and unlabeled (endogenous) corticosterone in adrenal mitochondria and in reconstituted cytochrome P-450 systems has been developed. An extract of an incubation of [14-14C]corticosterone is subjected both to thin-layer radiochromatography and to mass fragmentography (as O-methyloxime-trimethylsilyl ether derivative). In the latter procedure the ions at m/e 605 and 607 (specific for the derivatives of unlabeled and labeled 18-hydroxycorticosterone, respectively), at m/e 591 and 593 (specific for the derivatives of unlabeled labeled aldosterone, respectively) and at m/e 548 and 550 (specific for the derivatives of unlabeled and labeled corticosterone, respectively) were followed through the gas-liquid chromatography. From the ratio between the peaks obtained in the mass fragmentography and from the percentage conversion of [4-14C]corticosterone obtained in the thin-layer radiochromatography, the amount of endogenous and exogenous 18-hydroxycorticosterone and aldosterone could be calculated. The effects of time, enzyme, and substrate concentration of 18-hydroxylation were studied and optimal conditions for assay were determined. Under most conditions, the ratio between labeled and unlabeled 18-hydroxylated products was about constant, indicating that labeled and unlabeled corticosterone were not in equilibrium. It was ascertained that the 18-hydroxycorticosterone and aldosterone formed in the incubations were derived from corticosterone. [4-14C]18-Hydroxydeoxycorticosterone was not converted into aldosterone or 18-hydroxycorticosterone. In vitro studies with different 18-hydroxylase inhibitors (spironolactone, canrenone, and canrenoate-K) and studies with rats pretreated with KCl in drinking fluid suggest that 18-hydroxylation of corticosterone is catalyzed by an enzyme system different from that catalyzing 18-hydroxylation of deoxycorticosterone.  (+info)

Digoxin assays: frequent, substantial, and potentially dangerous interference by spironolactone, canrenone, and other steroids. (2/19)

BACKGROUND: A case of digoxin toxicity resulted from falsely low values with the MEIA II assay for digoxin (AxSYM; Abbott). The low results were caused by negative interference from canrenone and spironolactone, the latter of which has recently been advocated for the treatment of severe heart failure. Analytical interference from spironolactone has been reported, but little information is available for this effect with newer digoxin assays. METHODS: We examined nine assays (AxSYM, IMx, TDx, Emit, Dimension, aca, TinaQuant, Elecsys, and Vitros for interference by spironolactone, canrenone, and three metabolites. Additionally, all routine digoxin measurements (AxSYM) over a period of 16.5 months (n = 3089) were monitored for interference. RESULTS: Suppression of the expected values by canrenone (3125 microg/L) was observed for the AxSYM (42% of expected value), IMx (51%), and Dimension (78%) assays. A positive bias was observed for the aca (0.7 microg/L), the TDx (0.62 microg/L), and the Elecsys (>0.58 microg/L). Twenty-five of 669 routinely monitored patients had falsely low results. Nineteen of these had potentially toxic concentrations of digoxin (Emit; >2.0 microg/L), although the AxSYM assay indicated therapeutic or less severe toxic concentrations (Delta(max) = 7.1 microg/L). Except for two unresolved cases, this was attributable to spironolactone, canrenone, hydrocortisone, or prednisolone. Standard doses of spironolactone (up to 50 mg/day) in patients with heart failure displayed inhibition <11%. CONCLUSIONS: The frequency and magnitude of the false-negative results particularly compromise the use of both microparticle enzyme immunoassays. Not only may toxic concentrations remain unidentified, but intoxication could occur should dosage be increased because of falsely low results. With 11 million digoxin tests/year ordered in the US, conceivably many patients could be adversely affected.  (+info)

Aldosterone antagonist improves diastolic function in essential hypertension. (3/19)

Experimental studies demonstrated that mineralocorticoid antagonists prevent or reverse myocardial fibrosis. Therefore, we tested the hypothesis that the aldosterone antagonist canrenone can improve left ventricular diastolic function in essential hypertension. Using digitized M-mode echocardiography and 24-hour blood pressure monitoring (ABPM), we realized a prospective, randomized, controlled study on 34 never-treated essential hypertensives with left ventricular diastolic dysfunction. Echocardiogram and ABPM were repeated after 6 months of effective antihypertensive treatment with ACE inhibitors and calcium antagonists (second evaluation) and then after a 6-month period with 17 patients randomly assigned to add canrenone 50 mg/d to the previous treatment (third evaluation). At the basal evaluation 32 patients had left ventricular concentric hypertrophy, and 2 patients had left ventricular concentric remodeling. All the patients had normal left ventricular systolic function. At the second evaluation blood pressure was reduced (P<0.0001), left ventricular mass index decreased (P<0.0001), and diastolic function improved (P<0.0001). After randomization, the canrenone and control groups had similar 24-hour blood pressure and left ventricular morpho-functional characteristics. At the third evaluation, despite unchanged blood pressure and similar decrease of left ventricular mass index, the canrenone group, compared with control group, showed a significantly greater increase in left ventricular diastolic indices. In essential hypertension, a low dose of aldosterone antagonist added to antihypertensive treatment significantly improved left ventricular diastolic function. This improvement, not accounted for by changes in blood pressure and left ventricular mass, can be therefore ascribed to a direct action of the drug on the myocardium.  (+info)

Aldosterone receptor blockade improves left ventricular remodeling and increases ventricular fibrillation threshold in experimental heart failure. (4/19)

OBJECTIVES: To investigate the effects of aldosterone receptor blockade in postinfarction heart failure. METHODS: Eighty-seven rats with moderate myocardial infarction were randomized to receive either no drug or canrenone, the active metabolite of spironolactone, 20 mg/kg/day, or ramipril, 1 mg/kg/day, or a combination of the two drugs. Treatment was initiated 1 month after coronary ligation and lasted 4 weeks. Echocardiography was performed at baseline and after 4 weeks. LV catheterization, isolated heart studies, morphometric histology, myocardial norepinephrine and SERCA-2 mRNA were assessed at the end of the treatment period. RESULTS: Infarct sizes were 33+/-3, 32+/-3, 34+/-3, and 34+/-4% in the placebo, canrenone, ramipril, and combination groups, respectively. Canrenone attenuated LV remodeling, improved LV systolic and diastolic function, and markedly reduced interstitial and perivascular fibrosis. These effects were increased by concomitant ramipril therapy. Moreover, myocardial norepinephrine content was decreased while ventricular fibrillation threshold significantly augmented by canrenone. SERCA-2 levels remained unchanged. CONCLUSIONS: Canrenone attenuated LV dilation and interstitial remodeling, and improved LV filling dynamics and systolic function in the rat model of postinfarction heart failure. Addition of ramipril conferred further cardioprotection. Canrenone also reduced myocardial norepinephrine content and increased ventricular fibrillation threshold. The data provide a potential explanation for the decreased sudden death observed in the RALES study. The mechanisms of action of aldosterone inhibition are still poorly understood, despite its proven efficacy in heart failure. Rats with postinfarction heart failure were randomized to receive for 1 month either no drug or canrenone, or ramipril, or a combination of canrenone and ramipril. Canrenone treatment was associated with a significant attenuation of LV dilation, better LV diastolic and systolic dynamics, and a marked reduction of reactive fibrosis. These effects were enhanced by concomitant ramipril therapy. Moreover, canrenone increased ventricular fibrillation threshold and reduced myocardial norepinephrine content. The data may explain the reduced mortality demonstrated by the RALES.  (+info)

Safety of low-dose spironolactone administration in chronic haemodialysis patients. (5/19)

BACKGROUND: Prevention of cardiovascular diseases is essential in chronic haemodialysis patients. Recently, low-dose spironolactone has been shown to decrease cardiovascular mortality in patients with severe heart failure. However, since haemodialysis patients are prone to hyperkalaemia, a known side effect of spironolactone, this treatment is not used in this population. We performed a study to assess whether low-dose spironolactone (3 x 25 mg/week) could be administered without inducing hyperkalaemia in haemodialysis patients. METHODS: The study design included a 2-week baseline period, followed by a 4-week treatment period in which doses of spironolactone were started at 12.5 mg three times/week for 2 weeks, then increased to 25 mg three times/week, and followed by a 2-week wash-out period. Fourteen patients receiving low-dose spironolactone after each dialysis were compared with 21 haemodialysis patients (control group). RESULTS: Low-dose spironolactone did not change mean serum potassium (4.9 +/- 0.7 vs 4.9 +/- 0.3 mmol/l: control). The mean plasma canrenone level induced by administration of spironolactone 25 mg three times/week in the 14 treated patients was 13 +/- 5.3 ng/ml. Serum aldosterone was not significantly modified by the administration of spironolactone in these patients [before, median 0.35; interquartile range (IQR) 0.11-2.83 nmol/l vs after, median 0.22; IQR 0.12-0.60 nmol/l, NS]. Dietary potassium intake and the use of ion-exchange resin, angiotensin-converting enzyme inhibitors and beta-blockers were similar for the two groups throughout the study. CONCLUSION: This non-randomized and non-blinded study shows that administration of 25 mg spironolactone thrice weekly is not associated with an increased frequency of hyperkalaemia in haemodialysis patients when they are carefully monitored. More studies are required, however, before concluding that spironolactone administration is safe in the chronic haemodialysis population.  (+info)

The negative inotropic action of canrenone is mediated by L-type calcium current blockade and reduced intracellular calcium transients. (6/19)

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Spironolactone attenuates experimental uremic cardiomyopathy by antagonizing marinobufagenin. (7/19)

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Spironolactone and canrenone inhibit UGT2B7-catalyzed human liver and kidney microsomal aldosterone 18beta-glucuronidation: a potential drug interaction. (8/19)

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Spironolactone (SP) is used clinically as a renal aldosterone antagonist and as an antiandrogen. It is known that the drug is extensively metabolized and that metabolites mediate its therapeutic actions, but hepatic metabolism of SP has not been comprehensively investigated. Hepatic disposition may also be important in the toxicity of SP, because the parent compound prevents the hepatocarcinogenic effects of its metabolite, canrenone (CAN). Using a combination of in vivo and in vitro approaches, we studied the metabolism of SP by guinea pig livers. The major compounds detected in livers in vivo following SP treatment were the known metabolites, 7 alpha-thiomethyl-spirolactone (TM) and CAN, and a previously uncharacterized compound whose mass spectral and UV absorption characteristics suggested that it was an A-ring-reduced derivative of TM. In vitro incubation of liver homogenates with SP also resulted in the formation of the unknown metabolite. A combination of MS and NMR spectroscopy was used ...
A diuretic is any substance that promotes the production of urine. This includes forced diuresis. There are several categories of diuretics. All diuretics increase the excretion of water from bodies, although each class does so in a distinct way.. Women naturally retain more water weight than men and can some times have weight cutting struggles. Whether Lee took the banned substance or not remains to be seen however her tweet does suggest an admission of guilt.. MMAFighting.com is reporting that Lees urine test came back positive for the substances canrenone and/or spironolactone.. Lee has been temporarily suspended until a hearing is held. Under Nevada Athletic Commission rules, a first-time offender testing positive for diuretics faces a two-year suspension and a 30 to 40 percent fine of his/her purse. Lee earned a disclosed $3,000 payday at Invicta FC 16.. ...
The biotransformation of water insoluble substrates by mammalian and bacterial cells has been problematic, since these whole cell reactions are primarily performed in an aqueous environment The implementation of a twophase or encapsulated system has the advantages of providing a low water system along with the physiological environment the cells require to sustain themselves. Encapsulation of mammalian cells by formation of polyamide capsules via interfacial polymerization illustrated that the cells could not survive this type of encapsulation process. Biotransformation of the steroid spironolactone [3] by human kidney carcinoma cells was performed in a substrate-encapsulated system, yielding canrenone [4] in 70% yield. Encapsulation of nitrile-metabolizing Rhodococcus rhodochrous cells using a polyamide membrane yielded leaky capsules, but biotransformation of 2-(4- chlorophenyl)-3-methylbutyronitrile (CPIN) [6] in a free cell system yielded CPIN amide [7] in 40% yield and 94% ee. A two-phase ...
Medications approved for adults often have additional uses in pediatric patients. Such is the case - as described by Wessel and colleagues
Instrument: Osteometric board. The femur should be placed on the board in such a manner that one of the condyles touches the short vertical wall. Then the movable cross-piece should be applied on the other condyle where the head of the femur is touched tangentially. The readings should be collected from the graphical scale on the osteometric board. 3. Maximum diameter of the Head: This measurement reveals the greatest distance between the two laterally projected points on the head of the femur. Instrument: Sliding Caliper. Two arms of the sliding caliper are applied on the two points for taking measurement. 4. Middle shaft diameter (antero-posterior): This measurement denotes the distance between the anterior and posterior surfaces of the femur, especially at the middle of the shaft (at the height of the highest elevation, linea aspera). Instrument: Sliding Caliper. Since the points can be more or less determined by eye, so arms of the sliding caliper are placed on them very easily to take other ...
In this study, we generated proteome signatures after a short pulse of cisplatin treatment using two mouse models for specific breast cancer subtypes that display a marked difference in drug response. We report a comprehensive dataset of about 3400 proteins with 167 and 98 differentially expressed in the sensitive and resistant model, respectively. To our knowledge, this study provides the first and largest proteomic screen to date to identify cisplatin-responsive candidate markers shortly after treatment. Most notably, we identified highly discriminatory protein subsets of 56, 30, and 12 proteins that showed diverging patterns in the two models and could separate all four conditions using hierarchical clustering (see flowchart in Fig. 3 for selection of different discriminatory subsets).. To predict chemotherapy response, the additional use of tumor samples taken shortly after the first treatment may be advantageous over the common practice to find predictive markers only by using unchallenged ...
Sigma-Aldrich offers abstracts and full-text articles by [Sasha Singh, Michael Springer, Judith Steen, Marc W Kirschner, Hanno Steen].
Since ventricular fibrillation is the predominate cause of death following experimental coronary occlusion, measurement of the ventricular fibrillation threshold is recommended to assess the value of cardiac revascularization procedures. This determination is quantitative, precise and permits measurement under controlled circumstances. It was dissatisfaction with measurement of mortality rate following coronary occlusion in control and experimental animals (bioassay technic) that led to the adoption of the present more exact method.. Acute ligation of the anterior descending branch of the left coronary artery causes an immediate drop in the fibrillation threshold to one-fifth of normal. This is not changed if one releases the artery and retests the animal with occlusion 5 to 6 months later. Implantation of the internal mammary artery into the myocardium of the left ventricle creates a greater resistance to ventricular fibrillation after coronary occlusion. In animals in which the internal ...
The ventricular fibrillation threshold (VFT) was measured in 28 patients at the time of cardiac surgery. The VFT was measured with a 100 Hz train of 24 rectangular pulses positioned across the ST segment and T wave. Current was applied to the epicardial surface of either ventricle with a bipolar electrode probe. In six patients, the normal right VFT was 24.3 +/- 5.2 mA, and in 10 patients the normal left VFT was 33.6 +/- mA (p less than 0.05). In 12 patients with greater than or equal to 75% obstruction of the left anterior descending coronary artery, the left VFT was 18.6 +/- 6.9 mA. This value was significantly less than the left VFT in patients without coronary artery disease (p less than 0.001). This study shows that the VFT can be measured in man and that coronary artery disease reduces this parameter. ...
TY - JOUR. T1 - Effect of ligands of opiate receptors on morphofunctional state of the sympathoadrenal system and electrical stability of the heart in acute cold exposure. AU - Lishmanov, Yu B.. AU - Kondratev, B. Yu. AU - Maslov, L. N.. AU - Naryzhnaya, N. V.. PY - 1997/2. Y1 - 1997/2. N2 - Acute cold exposure (-20°C, 4 h) induces a transient decrease in the ventricular fibrillation threshold without morphological and radionuclide signs of irreversible damage to cardiomyocytes. The agonist of μ-receptors DAGO, which reduces adrenoreactivity of the myocardium, prevents the decrease in the ventricular fibrillation threshold induced by acute cold exposure.. AB - Acute cold exposure (-20°C, 4 h) induces a transient decrease in the ventricular fibrillation threshold without morphological and radionuclide signs of irreversible damage to cardiomyocytes. The agonist of μ-receptors DAGO, which reduces adrenoreactivity of the myocardium, prevents the decrease in the ventricular fibrillation ...
This page was last edited 01:50, 25 July 2014 by wikidoc user GeraldChi. Based on work by Cafer Zorkun and Alexandra Almonacid, wikidoc user WikiBot and wikidoc anonymous user Fvasconcellos ...
In this multicenter cohort, only ≈40% of patients referred for RDN, mostly by specialists, were eligible for the procedure, according to the SYMPLICITY HTN-2 criteria, as well as according to the centers own judgment. These data confirm at the European level the results obtained by Verloop et al18 in a Dutch single-center cohort, also included in ENCOReD. The proportion of less complex, standard patients with resistant hypertension in whom RDN seems both feasible and justified is probably still an order of magnitude lower (7.5% in patients with resistant hypertension hospitalized for hypertension in a French third referral center; 2.6% according to a recent US chart review)2,19 and might further decrease if all patients would be assessed for drug adherence20 or would have received maximal and optimized drug treatment, including low-dose spironolactone whenever possible.19. As in the Dutch study,18 patients found to be ineligible for RDN in our current study were older and had lower office and ...
In applications where the bearing size is determined by factors other than load - for example, shaft diameter constrained by critical speed - the bearing may be lightly loaded in relation to its size and carrying capacity. Where there are very light loads, failure mechanisms other than fatigue, such as skidding and smearing of raceways or cage damage, often prevail. To provide satisfactory operation, rolling bearings must always be subjected to a given minimum load. As a general rule, minimum loads of 0,01 C should be imposed on ball bearings and 0,02 C on roller bearings. More accurate minimum load requirements are given in the product sections ...
|ul| |li|5/16 shaft diameter|/li| |li|6 year warranty|/li| |li|1 AA battery required|/li| |li|Built-in hanger holds up to 4 lbs|/li| |li|Hand mounting hardware included|/li| |li|Designed for use with a |a href=https://www.klockit.com/all-departmen
|ul| |li|5/16 shaft diameter|/li| |li|2 year warranty|/li| |li|1 AA battery required|/li| |li|Built-in hanger holds up to 4 lbs|/li| |li|Hand mounting hardware included|/li| |li|Designed for use with a |a href=https://www.klockit.com/all-departmen
100% Natural Shea Butter! Shea Butter will provide improvement in all the conditions listed below. As you use this multi-purpose butter, you are likely to discover additional uses. The amount of time required for optimum results with various conditions may vary with each condition. Wrinkles, for example, require 4 to 6 weeks of daily use. Itching is relieved immediately.
A new surgical technique may (ELAR) is again performed through a small incision around the navel and using an HD camera, the muscles at the proper place, closed the hernia and abdominal wall stability are restored. With additional use of a classic plastic network or a completely resolution (absorbable) network this reconstruction will be held on time and the biomechanics of the abdominal and back muscles is again in the balance, so that often belong also passed back pain the past and Sport is again possible. About Stretched sagging skin, for example, just after pregnancy tightens after such an operation by itself, and plastic surgery (tummy tuck etc.) are usually unnecessary.. The operation is scheduled for individual examination incl. Ultrasound and then conducted by us at a partner hospital under Vollnachkose. After about 4-5 days a dismissal in the outpatient care is available and for 6 weeks a waist belt worn and lifting loads than 5 kg should be avoided. Then there are no more restrictions ...
There are approximately 20,000 new cases of rheumatoid arthritis in the UK every year [8]. These data show that most people who acquire RA do so when they are of working age and are productive, contributing members of society. It is obvious from the above that the incidence of RA amongst productive members of society in the European Union is causing significant distress, economic costs, and loss of productivity which affects Europeans quality of life in addition to placing additional burden on health care systems and health budgets across the EU. Therefore the economic impact of early intervention will be significant. Recent studies have indicated that early intervention can significantly reduce the clinical impact of the condition. Treatment choices for RA patients include corticosteroids and disease modifying anti-rheumatic drugs (DMARDs), such as methotrexate. For patients who fail to respond to these conventional therapies, the additional use of biologic TNF inhibitors offers greater ...
The mechanism underlying hypercalcaemia in TB is thought to be over-production of 1,25(OH)2D3 in extra-renal macrophages in granulomas, for example in the alveoli. It has been suggested that the production of 1,25(OH)2D3 has a protective effect against oxidative injuries from the nitric oxide burst from granulomatous macrophages [11]. This was initially studied in other granulomatous diseases, such as sarcoidosis. In TB, 1,25(OH)2D3 has been shown to be produced by alveolar macrophages from a patient with pulmonary TB [12], and high serum levels have been found in anephric patients, further supporting an extra-renal source [13]. Because production is extra-renal, the normal feedback control of 1,25(OH)2D3 production by parathyroid hormone is ineffective.. However, TB-associated hypercalcaemia has also been reported in patients with normal [4] and low [14] levels of serum 1,25(OH)2D3. Other causes may include an overdose of vitamin D or calcium supplements. An alternative possibility is abnormal ...
The analysis of triacylglycerol (TG) species is of interest in diseases that are associated with hypertriglycidemia. The individual composition of TGs seems to be of special interest in the...
The question whether the sequential diuretic therapy, that means using an antialdosteronic drug at first and adding a loop diuretic in nonresponders, is better than the combination of the two diuretics from the beginning (combined diuretic therapy) in the treatment of ascites in patients with cirrhosis is still open. Therefore, the aim of the study is to compare sequential versus combined diuretic therapy in these patients. One hundred patients will be randomized into two groups. Group A will receive potassium canrenoate at the initial dose of 200 mg/day, then increased up to 400 mg/day. Non responders will be treated with 400 mg/day of potassium canrenoate and furosemide at an initial dose of 50 mg/day, then increased up to 150 mg/day. Group B will receive at first 200 mg/day of potassium canrenoate and 50 mg/day of furosemide, then increased up to 400 mg/day and 150 mg/day, respectively.. The percentage of responders to dthe diuretic treatment, the time to get the resolution of ascites and the ...
Sigma-Aldrich offers abstracts and full-text articles by [Yasir H Siddique, Gulshan Ara, Tanveer Beg, Mohammad Afzal, Mohammad Faisal].
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Brooker and colleagues described their experience with an exciting new variable stiffness colonoscope. They made the point that a stiffer colonoscope shaft reduces recurrent looping but makes passage through an angulated sigmoid more difficult and causes more stretching and hence pain when loops do occur. Conversely, the more flexible thinner paediatric instruments are better for negotiating a fixed or narrow sigmoid colon but then tend to allow recurrent loop formation later in the procedure. Their randomised trial using either a standard Olympus CF200HL (13.3 mm shaft diameter) or a prototype (Olympus XCF-SH230L-12.9 mm shaft diameter) variable stiffness colonoscope looked very promising although in one case a paediatric Olympus PCF230I (11.3 mm shaft diameter) was required to get past a fixed sigmoid secondary to diverticular disease.. In addition to Brooker et al, there are a number of research workers1-4 and endoscope manufacturers interested in colonoscope/flexible sigmoidoscope shaft ...
This randomized trial showed that the addition of spironolactone in patients with resistant arterial hypertension using a mean of 4.5 antihypertensive drugs, led to a significant decrease of systolic BP both in the office and on ABPM after 8 weeks of treatment. Spironolactone, compared to the placebo, did not significantly influence the diastolic BP, although a trend toward a decrease was observed for the ABPM nighttime and office diastolic BP. Spironolactone led to small but significant increases of serum potassium and creatinine without adverse clinical consequences and was well tolerated, and the number of side effects was comparable to the placebo.. To our knowledge, this is the first randomized trial to assess the antihypertensive effects of low-dose spironolactone in patients with truly drug-resistant hypertension. Previous uncontrolled observational trials showed a substantial BP reduction after the addition of spironolactone (ranging from 21.7 to 25 mm Hg systolic and 8.5 to 12.5 mm Hg ...
Increased blood volume and red blood cell mass Increased skeletal muscle capillary density, mitochondrial mass, and oxidative capacity Increased left ventricular mass, end-diastolic dimension, and stroke volume Increased diameter of coronary arteries Decrease in resting heart rate Likely increase in ventricular fibrillation threshold Explain the different cardiovascular responses to volume overload and pressure overload. Exercise […] Read more. ...
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The originals of images offered in this catalog were contributed to the Mammal Images Library with the understanding that the Mammal Images Library will sell copies only for optical projection for nonprofit instruction. However, some contributors will allow their slides to be used for other purposes; this permission is set forth in a written Contribution Agreement between the contributors and the Mammal Images Library. These additional permissible uses, and arrangements for royalties derived from additional uses, vary among the contributors. Persons or organizations wishing to use images for purposes other than projection for nonprofit instruction or copying the slide in any way must first contact the Chair of the Mammal Images Library to get information about the use of specific images. Failure to obtain the required permission jeopardizes the ability of the Mammal Images Library to operate its program. This program depends on the good will of contributors, the voluntary efforts by the MIL ...
Branch Whitneys Hiking Las Vegas: Protect Your Ropes with Chafe Pro. "Chafe-Pro®s chafe guards have been designed specifically for the recreational boater who use smaller diameter lines (ropes). However, I have found an additional use for them: to protect hand lines (ropes) that have been permanently placed in the mountains to assist hikers/climbers up difficult sections of rock.. What happens is the rope becomes abraded as it rubs across the rock. Over time this can compromise the rope and it can become dangerous. Normally we replace the ropes when needed. By covering the rope with Chafe-Pro®s chafe guards the rope will not become abraded thus keeping hikers and climbers safe.. The chafe guards I have are 26 inches in length. They are closed along the length (all 26 inches) and on each end by heavy-duty velcro. They are very thick and should protect the rope for years. Chafe guards are very flexible and can bend around the rock ...
Accompanying the increased use of water resources is an increases accumulation of chemical pollutants. Te prevent degradation of the water resources beyong useful limits, pollution inputs from additional uses must be quite accurately predicted prior to implementation of the new use. The model described in this report was formulated to provide the required predictive capability for the Bear River Basin. Modeling concepts of the hydrologic system are based upon the development of basin relationships describing the hydrologic processes which are linked together by the countinuity-of-mass principle. The salinity flow system is then linked to the hydrologic system based on the assumtion that the various hydrolgoci processes change the chemical concentration in the system by storing, concentrating, diluting, and/or picking up additional salts. These
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This study will investigate the effects of anti-digoxin polyclonal antibody [DIGIBIND] on marinobufagenin levels in pregnant women with preeclampsia.
Is Malaise a common side effect of Spironolactone? View Malaise Spironolactone side effect risks. Female, 70 years of age, weighting 119.0 lb, was diagnosed with local swelling, pain and took Spironolactone 0.5 Df, 1x/day.
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To conclusively determine whether aldosterone antagonists confer additional benefit on reducing SCDs in patients with ICDs, one would need to design a study in which patients with ICDs (and preferably a group without ICDs as well) were randomized to aldosterone antagonists versus placebo in addition to the usual heart failure medicines. Unfortunately, and to the best of our knowledge, such a study has not been performed. We have been able to obtain some observational retrospective data from MADIT II and the COMPANION trial that address this issue to some extent. We briefly present our findings, realizing that limitations exist that must be kept in mind when these data are viewed. The limitations of this analysis include the following: a lack of randomization for the use of spironolactone; a relatively small number of patients who were assigned to spironolactone, which resulted in the studies not being powered to definitely answer the question about a benefit of aldosterone antagonists in ...
Rationale and design of the Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist Trial: A randomized, controlled study of spironolactone in patients with symptomatic heart failure and preserved ejection fraction.
p,Ischemic preconditioning has been acknowledged as a powerful method of decreasing ischemic injury. However, the antiarrhythmic mechanism of ischemic preconditioning during ischemia is unclear. We studied the effects of ischemic preconditioning on arrhythmias and cardiac electrophysiology during ischemia in Langendorff rat hearts (n = 44). In the non-preconditioned group (PC(-); n = 24), the hearts underwent 5-min zero-flow global ischemia without any prior ischemic preconditioning. In the preconditioned group (PC(+); n = 20), the hearts were preconditioned by three cycles of 3-min zero-flow global ischemia and 5-min reperfusion before undergoing 5-min global ischemia. Ischemic preconditioning reduced the incidence of ischemia-induced arrhythmias (PC(-); 38.9%, PC(+): 8.3%, p , 0.05), shortened monophasic action potential duration (MAPD, P , 0.05), attenuated conduction delay (conduction time; PC(-): 234.2%, PC(+): 173.4%, P , 0.05) and increased the ventricular fibrillation threshold. Although ...
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At least 40% of the patients with prostate cancer (PC) present with positive lymph nodes (N1). The optimal treatment strategy for these patients remains controversial. Although androgen deprivation therapy (ADT) is still often initiated as only treatment, the results are disappointing. Recent studies support the use of more aggressive therapies including external beam radiotherapy (EBRT) and ADT. The retrospective studies supporting the additional use of EBRT in N1 PC patients are however not conclusive regarding to the extent of radiation field.. Even after an EPLND, there might be a role for pelvic EBRT in irradicating microscopic disease. However pelvic irradiation irrevocably results in increased toxicity. Moreover, in node negative (N0) PC patients the addition of pelvic EBRT has not resulted in improved outcome in randomised trials. However in the setting of Tumor Node Metastasis pathological stage (p)N1, proven on pathological examination, PC patients this has never been evaluated so far. ...
Because of the important interaction between phosphate and magnesium ions, magnesium ions are essential to the basic nucleic acid chemistry of life, and thus are essential to all cells of all known living organisms. Over 300 enzymes require the presence of magnesium ions for their catalytic action, including all enzymes utilizing or synthesizing ATP, or those that use other nucleotides to synthesize DNA and RNA. ATP exists in cells normally as a chelate of ATP and a magnesium ion.. Plants have an additional use for magnesium in that chlorophylls are magnesium-centered porphyrins. Magnesium deficiency in plants causes late-season yellowing between leaf veins, especially in older leaves, and can be corrected by applying Epsom salts (which is rapidly leached), or else crushed dolomitic limestone to the soil. Magnesium is a vital component of a healthy human diet. Human magnesium deficiency (including conditions that show few overt symptoms) is relatively rare[18] although only 32% of the United ...
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Spironolactone is a potassium-containing diuretic, which means that when the excess liquid is precipitated, it retains the potassium in the body and ...
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Aldactone (spironolactone) is used to diagnose or treat a condition in which you have too much aldosterone in your body. Includes Aldactone side effects, interactions .... ...
Familial hyperaldosteronism is a group of inherited conditions in which the adrenal glands, which are small glands located on top of each kidney, produce too much of the hormone aldosterone. Aldosterone helps control the amount of salt retained by the kidneys. Excess aldosterone causes the kidneys to retain more salt than normal, which in turn increases the bodys fluid levels and blood pressure. People with familial hyperaldosteronism may develop severe high blood pressure (hypertension), often early in life. Without treatment, hypertension increases the risk of strokes, heart attacks, and kidney failure.. Familial hyperaldosteronism is categorized into three types, distinguished by their clinical features and genetic causes. In familial hyperaldosteronism type I, hypertension generally appears in childhood to early adulthood and can range from mild to severe. This type can be treated with steroid medications called glucocorticoids, so it is also known as glucocorticoid-remediable aldosteronism ...
Aldosterone antagonists (or aldosterone blockers) are a class of medications used to treat high blood pressure and heart failure. They work on the same hormone system as ACE inhibitors and ARBs, but in a slightly different way. Aldosterone antagonists block the receptors in the body for the hormone aldosterone, causing the kidneys to hold onto more potassium and get rid of more fluid by increasing urine output. Less fluid in the body means lower blood pressure and less total blood volume, reducing the hearts workload and easing the strain on the heart. Getting rid of excess fluid helps relieve the symptoms of heart failure that are caused by fluid buildup, such as shortness of breath and swelling in the legs.. Aldosterone antagonists are not routine therapy for women with heart failure because they are less proven than other medications in the same class, including ACE inhibitors and ARBs. but are beneficial in selected women with systolic heart failure(blood pumping problems) who have recently ...
Bretylium tosylate (Bretylol) has recently been approved for parenteral use against resistant ventricular arrhythmias. The pharmacologic action of bretylium is complex, and its antiarrhythmic action differs significantly from other drugs. Bretylium is an adrenergic neuronal blocking agent taken up selectively at peripheral adrenergic nerve terminals, where it initially releases norepinephrine (sympathomimetic effect) and then produces adrenergic neuronal blockade. It has direct cardiac membrane effect to prolong action potential duration and effective refractory period but, unlike other membrane active antiarrhythmic agents, does not depress conduction velocity or automaticity. Bretylium increases ventricular fibrillation threshold and prevents the decrease in ventricular fibrillation threshold associated with myocardial ischemia. It does not depress myocardial contractility. Clinical studies have shown parenteral bretylium to be effective in suppressing ventricular arrhythmias, particularly ...
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Abstract Spironolactone has been noted to attenuate cardiac fibrosis. We have observed that the cardiotonic steroid marinobufagenin plays an important role in the diastolic dysfunc..
This article reviews the literature focusing on the use of oral spironolactone in this subset of women with acne vulgaris, including discussions of the recommended starting dose, expected response time, adjustments in therapy, potential adverse effects, and patient monitoring. Acne vulgaris (AV) is usually perceived as a ‎Background on · ‎Which Oral Contraceptives · ‎What Clinical Evaluation. Author information ▻ Article notes ▻ Copyright and License information ▻ There is limited evidence on the safety and efficacy of spironolactone in the treatment of women with acne. Thus, for A majority of women in this study saw a dramatic improvement in their acne while treated with spironolactone.‎Introduction · ‎Results · ‎Discussion · ‎Limitations.. Can I take Buspar at the same time Im taking Ativan, by reducing the amount of Ativan. Amount: Usually, but it spironolactone article take a substitute decrease in ativan and you may see some spironolactone article. CAN I TAKE ...
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(2003) Casale et al. Revue de Laryngologie Otologie Rhinologie. AIM OF THE STUDY: Evaluation of hearing results after implantation of a fluoroplastic-platinum piston (FP) and of a titanium piston (T) with a shaft diameter of respectively 0.6 mm and 0.4 mm, in c...
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While a significant portion of the museums collection has been photographed, there are times when images are not readily available. If imaging is needed, you will be notified and given the option to request new photography. New photography generally takes between six and eight weeks to complete and prepayment is required. The museum reserves the right to cancel requests for new photography, but an appropriate explanation and full refund will be given. In some cases, photographic prints are not available due to copyright.. Note: Permission to reproduce and the image fees cover only the specific use detailed in the application. Any and all reprints, further editions, re-use of the printing plates, or additional use of any kind must be preceded by a new application and is not covered by the original fee or permission to reproduce. You will receive more specific details upon ordering digital files.. ...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Spironolactone - What is spironolactone? What are the side affects to this medican? See below. Spironolactone is a pottassium sparing diuretic. A diuretic is a medication which enhances fluid and salt excretion from the kidney. Spironolactone is a weak diuretic and is used because it does not require pottassium supplementation unlike other diueretics. It is also used to treat high blood pressure and heart problems.
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Have you tried an injection of frusemide/lasix to relieve the fluid? Also the addition of spironolactone, another diuretic? Though I lost my Lucy earlier this week, she had an additional happy 5 months after adding in spironolactone, which made a huge difference, and this kept her breathing far more comfortable. I had to up the dose once from 10mg to 20mg, the top of what she could get at her weight, but it really made such a difference for her ...
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Spironolactone is effective for NYHA class III and IV heart failure and hypertension (4th or 5th line) but can be a difficult drug to use. Elevated serum potassium levels may occur in around 18% of patients.. In a case-control study spironolactone was associated with a doubling in the rate of gastrointestinal bleed events.1 This effect was stronger with increasing doses and when spironolactone was combined with NSAIDs/corticosteroids.. Medicines & Healthcare products Regulatory Agency (UK) now advise that "use of spironolactone with ACEi or ARB increases the risk of severe hyperkalaemia, particularly in patients with marked renal impairment, should be used with caution", and requires regular monitoring of renal function.2. Spironolactone should only be started if serum potassium ≤5.0mmol/L and serum creatinine is ≤221 μmol/L. Monitor serum potassium and creatinine 1 week after initiation or increase in dose of spironolactone, monthly for the first 3 months, then quarterly for a year, and ...
IRVINE, Calif. A biotech company focused on cancer treatments has received a rejection letter from the Food and Drug Administration for its application for a drug to treat non-Hodgkins lymphoma.. Spectrum Pharmaceuticals said the FDA rejected its application seeking approval for an additional use of Zevalin (ibritumomab tiuxetan), as a first-line consolidation treatment for NHL. The drug already has approval to treat patients with relapsed or refractory, low-grade or follicular B-cell NHL.. Spectrum said it would submit the additional data the FDA requested by Wednesday.. ...
UCL-TB member Rob Aldridge was an author on the above paper on a cluster randomised controlled trial. The objective was to compare current practice for encouraging homeless people to be screened for tuberculosis on a mobile digital X-ray unit in London, UK, with the additional use of volunteer peer educators who have direct experience of tuberculosis, homelessness or both.. 46 hostels took part in the study, with a total of 2342 residents eligible for screening. The study took place between February 2012 and October 2013 at homeless hostels in London, UK. You can find the full publication here. ...
The discipline of biometrics may be broadly defined as the study of using metrics related to human characteristics as a basis for individual identification and authentication, and many approaches have been implemented in recent years for many different scenarios. A sub-section of biometrics, specifically known as soft biometrics, has also been developing rapidly, which focuses on the additional use of information which is characteristic of a user but not unique to one person, examples including subject age or gender. Other than its established value in identification and authentication tasks, such useful user information can also be predicted within soft biometrics modalities. Furthermore, some most recent investigations have demonstrated a demand for utilising these biometric modalities to extract even higher-level user information, such as a subject\textsc{\char13}s mental or emotional state. The study reported in this thesis will focus on investigating two soft biometrics modalities, namely ...
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Two Drug Protocol To Be Used When Carrying Out ExecutionsPhoenix, AZ (Wednesday, March 26, 2014) -- Attorney General Tom Horne is today announcing that the Arizona Department of Corrections (DOC) has changed its lethal injection protocol to allow for the additional use of a two-drug protocol using Medazolam and Hydromorphone in carrying out executions.
Liver Damage | Symptoms - Liver Damage Symptoms and Medical Problems Ascites Salt restriction is often necessary, as cirrhosis leads to accumulation of salt (sodium retention). Diuretics may be necessary to suppress ascites. Diuretic options for inpatient treatment include aldosterone antagonists (spironolactone) and loop diuretics. Aldosterone antagonists are preferred for people who can take oral medications and are not in need of an urgent volume reduction. Loop diuretics can be added as additional therapy. If a rapid reduction of volume is required, paracentesis is the preferred option. This procedure requires the insertion of a plastic tube into the peritoneal cavity. Human albumin solution is usually…
Aldosterone antagonist therapy reduces mortality in patients with moderate to severe heart failure. The EMPHASIS-HF trial demonstrated the efficacy of eplerenone in reducing mortality as well as risk of hospitalization in patients with systolic heart failure and mild symptoms.. One should use aldosterone antagonist therapy to treat heart failure in patients with NYHA functional class II HF and LVEF ≤30 percent, or NYHA functional class III to IV heart failure and LVEF ,35 percent, if they can be carefully monitored for serum potassium and renal function.. Dr KK ...
While his web persona has been described as a "blogvocateur," Dr. Sidorov has wide range of knowledge about the medical home, condition management, population-based health care and managed care that is only exceeded by his modesty. He has been quoted by the Wall Street Journal, Consumer Reports and NPRs All Things Considered. He has over 20 years experience in primary care, disease management and population based care coordination. He is a primary care general internist and former Medical Director at Geisinger Health Plan. He is primary care by training, managed care by experience and population-based care strategies by disposition. The contents of this blog reflect only the opinions of Sidorov and should not be interpreted to have anything to do with any current or past employers, clients, customers, friends, acquaintances or enemies, personal, professional, foreign or domestic. This is also not intended to function as medical advice. If you really need that, work with a personal physician or ...
In this analysis of patients with moderately severe to severe HF with reduced EF who were randomized to a MRA or placebo, self-identified AA patients developed less hyperkalemia but higher rates of hypokalemia while taking spironolactone compared with similarly treated non-AA patients. Despite a similar initial study drug dose, potassium concentrations increased substantially in non-AA individuals assigned to spironolactone within a month after randomization, whereas potassium levels in AA participants did not change significantly. However, AA participants seemed to derive less clinical benefit from an MRA.. Differences in potassium response to spironolactone among AA and non-AA participants were evident early in the study and persisted throughout the trial. Potassium levels of non-AA participants increased, on average, by 0.25 mmol/L while taking spironolactone compared with those taking placebo. Changes in potassium concentrations were minimal in AA participants. In addition, there were lower ...
Spironolactone goodies liquid preservation in sufferers with congestive cardiovascular failing Spironolactone Weight Loss, cirrhosis, or kidney complications. This medicine may boost your potassium amounts. Aldactone supplements are solely supposed for dealing with particular medical circumstances and not really for fat reduction. Fat reduction that might result pursuing the make use of of spironolactone is certainly credited to its diuretic properties. Find out about Aldactone (Spironolactone) may deal with, uses, medication dosage, aspect results, medication connections, alerts, individual labels, testimonials, and related medicines. This tablet can help remove surplus liquid and salt from the body. This medication is certainly a white, oval, have scored, film-coated, tablet printed with "Sixth is v" and "58 81". It is certainly also a effective diuretic, flushing surplus liquid from the body and dealing with the indication of drinking water preservation. The fat reduction impact of this ...
What is spironolactone and hydrochlorothiazide? Learn about spironolactone and hydrochlorothiazide side effects, how to take spironolactone and...
The FDA has just approved Pfizers aldosterone antagonist Inspra (eplerenone) for the treatment of heart failure. It had already been approved for treating hypertension.. Please forgive me if I dont get up and dance for joy.. Im not saying it isnt a good thing to have a new, more effective drug on the market if youre suffering from congestive heart failure. Im also glad Pfizer is continuing to introduce new drugs for the treatment of life-threatening conditions, rather than limit itself to lucrative "lifestyle" drugs like Viagra.. But I am reminded that our countrys approach to medicine, drug development, and public health succeeds in some ways by failing in others.. Inspra isnt going to be cheap. For the well-heeled and well-insured suffering from congestive heart failure, the drug will be a good thing because it will be available. But for the rest of us, Inspra may not only be unavailable, but may also contribute to rising health-insurance premiums and force more of us to drop our ...
Eplerenone is an aldosterone antagonist that is used to treat heart conditions. Learn more about eplerenone medication, dosages and potential side effects at Patient
Aldactone hirsutism / clinical trials for spironolactone / what is aldactone used for / aldactone drug interactions : And while spells danger both work can induce abortion.
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For the safe and simultaneous identification of RNA from the North American (NA) and European (EU) genotypes of porcine reproductive and respiratory syndrome virus (PRRSV).
Buy Spirono Online! Spirono is the generic form of the brand-name drug Spirono, a prescription diuretic drug. Spirono helps restore a healthy balance of sodium and potassium in your body.
Aldazide information about active ingredients, pharmaceutical forms and doses by Pfizer, Aldazide indications, usages and related health products lists
KEY POINTS: Animal studies suggest an anti-fibrillatory action of the vagus nerve on the ventricle, although the exact mechanism is controversial. Using a Langendorff perfused rat heart, we show that the acetylcholine analogue carbamylcholine raises ventricular fibrillation threshold (VFT) and flattens the electrical restitution curve. The anti-fibrillatory action of carbamylcholine was prevented by the nicotinic receptor antagonist mecamylamine, inhibitors of neuronal nitric oxide synthase (nNOS) and soluble guanylyl cyclase (sGC), and can be mimicked by the nitric oxide (NO) donor sodium nitroprusside. Carbamylcholine increased NO metabolite content in the coronary effluent and this was prevented by mecamylamine. The anti-fibrillatory action of both carbamylcholine and sodium nitroprusside was ultimately dependent on muscarinic receptor stimulation as all effects were blocked by atropine. These data demonstrate a protective effect of carbamylcholine on VFT that depends upon both muscarinic and
Spironolactone is a steroidal potassium-sparing diuretic used in the treatment of oedema, hypertension and hyperaldosteronism.. 5.2 Human carcinogenicity data. Spironolactone was mentioned specifically in two cohort studies and one case control study. In one cohort study carried out in the USA, an excess risk for pharyngeal cancer was found, which persisted with longer follow-up. No evidence for an association with breast cancer was found in the other cohort study, and use of spironolactone was not associated with thyroid cancer in one case control study. All three studies were based on small numbers of cases.. In five case control studies of renal-cell carcinoma, use of potassium-sparing diuretics was not clearly identified as a risk factor independently of hypertension.. 5.3 Animal carcinogenicity data. Spironolactone was tested by oral administration in one study in rats. Increased incidences of thyroid follicular-cell adenomas and Leydig-cell tumours of the testis were reported. ...
It is a synthetic 17-lactone drug that is a renal competitive aldosterone antagonist in a class of pharmaceuticals called potassium-sparing diuretics, used primarily to treat heart failure, ascites in patients with liver disease, low-renin hypertension, hypokalemia, secondary hyperaldosteronism (such as occurs with hepatic cirrhosis), and Conns syndrome (primary hyperaldosteronism). On its own, spironolactone is only a weak diuretic because its effects target the distal nephron (collecting tubule), where urine volume can only be slightly modified; but it can be combined with other diuretics to increase efficacy. About one person in one hundred with hypertension has elevated levels of aldosterone; in these persons, the antihypertensive effect of spironolactone may exceed that of complex combined regimens of other antihypertensives.. Due to its antiandrogen effect, it can also be used to treat hirsutism. It is also used for treating hair loss and acne in women, and can be used as a topical ...
Merck & Co. said Tuesday its schizophrenia drug Saphris has been approved for two additional uses by the Food and Drug Administration.. The drug was first approved in August 2009 for treating acute schizophrenia episodes in adults and acute mania or manic-depressive behavior in adults with bipolar disorder.. Merck says the FDA now has approved Saphris for ongoing treatment of schizophrenia and for treating acute mania or manic-depressive behavior in adult bipolar patients along with lithium, a mood-stabilizing drug often used to treat mania, or the antiseizure drug valproate.. Saphris carries the FDAs strongest caution, a black box warning, that it nearly doubles risk of death in elderly patients with dementia.. Like similar drugs, it has many other serious potential risks, including strokes, heart problems, high blood sugar and diabetes, suicide, seizures, fainting, a drop in infection-fighting white blood cells, sedation and impaired thinking, and neuroleptic malignant syndrome, a ...
Canrenone. 155 ng/mL (455 nmol/L). 181 ng/mL (532 nmol/L). 2,173 ng•hour/mL (6,382 nmol•hour/L). 16.5 hours ... 7α-TMS has been found to account for around 80% of the potassium-sparing effect of spironolactone,[6][9][10] whereas canrenone ... and 16.5 hours for canrenone, and accordingly, these metabolites are responsible for the therapeutic effects of the drug.[5][6] ...
... and canrenone (the 1,2-didehydro analogue of SC-5233). Spironolactone is a derivative of SC-5233 with a 7α-acetylthio group ( ... canrenone (SC-9376; Cantaren, Luvion), potassium canrenoate (SC-14266; Venactone, Soldactone), eplerenone (SC-66110, CGP-30083 ...
Canrenone P. J. Bentley (1980). Endocrine Pharmacology: Physiological Basis and Therapeutic Applications. CUP Archive. pp. 160 ...
... and canrenone (SC-9376). Spironolactone is a prodrug with a short terminal half-life of 1.4 hours. The active metabolites of ... and 16.5 hours for canrenone, and accordingly, these metabolites are responsible for the therapeutic effects of the drug. 6β- ...
Potassium canrenoate Canrenone J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures ...
Canrenone Drospirenone Spironolactone J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, ...
Canrenoic acid Canrenone Hans Selye (17 April 2013). Hormones and Resistance: Part 1 and. Springer Science & Business Media. pp ... Like spironolactone, it is a prodrug, and is metabolized to active canrenone in the body. Potassium canrenoate is notable in ...
Canrenone Mexrenone Prorenoate potassium Prorenoic acid Potassium canrenoate Claire, M.; Rafestin-Oblin, M. E.; Michaud, A.; ... Prorenone can be synthesized via a Johnson-Corey-Chaykovsky reaction by reaction of canrenone with trimethylsulfonium iodide ...
Canrenone Mexrenoate potassium Mexrenoic acid Potassium canrenoate Prorenone Cutler, Gordon B.; Pita, Julio C.; Rifka, Safa M ...
It is an analogue of other spirolactones like spironolactone and canrenone. The compound has a molecular weight of 366.493 g/ ...
Fernandez MD, Carter GD, Palmer TN (January 1983). "The interaction of canrenone with oestrogen and progesterone receptors in ...
... canrenone, eplerenone. ...
... canrenone), triameterene, and trichlormethiazide. Bumetanide is a loop diuretic (water pill) that prevents your body from ...
On December 21, 2012 Vessey accepted a public warning and loss of results for testing positive for canrenone. She admitted to ...
... and canrenone (SC-9376). Spironolactone is a prodrug with a short terminal half-life of 1.4 hours. The active metabolites of ... and 16.5 hours for canrenone, and accordingly, these metabolites are responsible for the therapeutic effects of the drug. 7α-TS ...
"The interaction of canrenone with oestrogen and progesterone receptors in human uterine cytosol". British Journal of Clinical ...
More recently, when blood samples from 366 patients in the TOPCAT study were analyzed for presence of canrenone (an active ... However, only very small amounts of spironolactone and its metabolite canrenone enter breast milk, and the amount received by ... However, eplerenone may not be as effective as spironolactone or the related medication canrenone in reducing mortality from ... metabolite of spironolactone), 30% of blood samples from Russia lacked detectable residues of canrenone. This led to the ...
The molecular formula C22H28O3 (molar mass: 340.45 g/mol, exact mass: 340.203845) may refer to: Canrenone, an aldosterone ...
Similarly to other spirolactones like canrenone and spironolactone, SC-5233 has some antiandrogen activity and antagonizes the ...
... canrenone and hydrochlorothiazide in patients with therapy-refractory arterial hypertension. In: J Pharm Biomed Anal. 164, 5. ...
Canrenone and potassium canrenoate - very limited use Finerenone - nonsteroidal and more potent and selective than either ...
... canrenone (INN) Cantharone Cantil cantuzumab mertansine (INN) cantuzumab ravtansine (USAN, INN) Cap-Profen capadenoson (INN) ...
19-norspirolactone Canrenone (aldadiene) = Δ6-spirolactone Dicirenone (SC-26304) = 7α-carboxyisopropylspirolactone Drospirenone ...
Canrenone (aldosterone antagonist) Medrogestone (progestin) The second can also be between carbons 1 and 2 on ring A: ...
... canrenone MeSH D04.808.745.432.144 --- chlormadinone acetate MeSH D04.808.745.432.219 --- cyproterone MeSH D04.808.745.432. ...
C03DA01 Spironolactone C03DA02 Potassium canrenoate C03DA03 Canrenone C03DA04 Eplerenone C03DB01 Amiloride C03DB02 Triamterene ...
A list of US medications equivalent to Canrenone is available on the Drugs.com website. ... Canrenone is a medicine available in a number of countries worldwide. ...
... ,ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory ... Canrenone, Urine. 2. SAFE-T-FILL Serum. 3. SAFE-T-FILL Serum Mini Capillary Collection Tubes. 4. SAFE-T-FILL Serum Gel Mini ...
Canrenone is mainly used as a diuretic.[citation needed] Canrenone has been found to be effective in the treatment of hirsutism ... Canrenone is the INN and USAN of the drug. Canrenoic acid Potassium canrenoate Jürg Müller (6 December 2012). Regulation of ... Canrenone is an active metabolite of spironolactone, canrenoic acid, and potassium canrenoate, and is considered to be ... Canrenone is reportedly more potent as an antimineralocorticoid relative to spironolactone, but is considerably less potent and ...
Serbuk 11a-Hydroxy canrenone methacrylate (192704-56-6) Spembungkusan:. Struktur Kimia: Nama Produk:11α-Hydroxy canrenone ... Serbuk methacrylate 11α-Hydroxy canrenone (192704-56-6) Deskripsi:. Metaacrylate 11α-Hydroxy canrenone berfungsi sama seperti ... Serbuk methacrylate 11α-Hydroxy canrenone (192704-56-6). / Produk / Lain-lain / 11α-Hydroxy canrenone methacrylate Powder ( ... Sinonim: 11-a-Hydroxy canrenone metil ester. Penyimpanan: Kering, gelap · dan pada 0 - 4 C untuk jangka pendek (hari hingga ...
11der-Hydroxy canrenone methacrylate Powder (192704-56-6) Duchunguzi:. 11cy-Hydroxy canrenone methacrylate inafanya kazi sawa ... 11der-Hydroxy canrenone methacrylate Powder (192704-56-6). / Bidhaa / wengine / 11α-Hydroxy canrenone Powacrylate Powder ( ... 11der-Hydroxy canrenone methacrylate Powder (192704-56-6) Specification:. Uundo wa Kemikali: Jina la bidhaa:11cy-Hydroxy ... Majina mengine: 11-a-Hydroxy canrenone methyl ester. Uhifadhi: Kavu, giza · na saa 0 - 4 C kwa muda mfupi (siku hadi wiki) au - ...
Canrenone. 155 ng/mL (455 nmol/L). 181 ng/mL (532 nmol/L). 2,173 ng•hour/mL (6,382 nmol•hour/L). 16.5 hours ... 7α-TMS has been found to account for around 80% of the potassium-sparing effect of spironolactone,[6][9][10] whereas canrenone ... and 16.5 hours for canrenone, and accordingly, these metabolites are responsible for the therapeutic effects of the drug.[5][6] ...
Canrenone CAS NO:976-71-6 rnAlias: 17-hydroxy-3-oxo-17a-pregna-4, 6-diene-21-carboxylic acid gamma-lactone rnCAS NO:976-71-6 ... Sell Canrenone CAS NO:976-71-6 - Sep, 28 2015. Canrenone CAS NO:976-71-6. Alias: 17-hydroxy-3-oxo-17a-pregna-4, 6-diene-21- ... Home › Sell Canrenone CAS NO:976-71-6 › Hubei Yuancheng Saichuang Raw steriod Co.,Ltd. ... Sell Canrenone CAS NO:976-71-6 Hubei Yuancheng Saichuang Raw steriod Co.,Ltd. ...
Canrenone. 15 mg. EPC0410000. Add to basket Cape jasmine fruit for system suitability. 260 mg. EPY0001858. Add to basket ...
Canrenone. 15 mg. EPC0410000. Add to basket Cape jasmine fruit for system suitability. 260 mg. EPY0001858. Add to basket ...
Canrenone. Tag:Canrenone. You may also be interested in:Garlic Seed OilElderberry seed oilnut and seed oilBlack Currant Seed ...
The only significant covariate was weight (WT). The final population models for canrenone clearance (CL/F) and volume of ... The only significant covariate was weight (WT). The final population models for canrenone clearance (CL/F) and volume of ... The only significant covariate was weight (WT). The final population models for canrenone clearance (CL/F) and volume of ... The only significant covariate was weight (WT). The final population models for canrenone clearance (CL/F) and volume of ...
... canrenone); triameterene; trichlormethiazide; etc. ...
Tennessee Titans: Owner: Amy Adams Strunk. Strunk herself hasnt personally offered a statement, but before the protest policy was put on hold, WKRN reported that head coach Mike Vrabel said that if Titans players decide to stay inside during the national anthem they have Strunks full support. He said, "I told them this morning they had the entire organizations and Miss Amys support to make a decision when that time came." No Titans player has taken a knee and the team has not addressed how it will respond should a player decide to protest on the field.. AFC West. Kansas City Chiefs. Owner: Clark Hunt. Last year, before a game with the Cowboys in November Clark Hunt said, "When it rolled around last year, it really wasnt a big deal for us, and weve tried to stay with that this year. Obviously weve had some guys who have sat or knelt during some of the games this year, but weve continued to work with them and communicate with them that we prefer for them to stand. But at the end of the ...
Established in April, 1998, Xianju Green Leaf Pharmaceutical Factory is an enterprise specializing in produicng steroidal hormone drugs and intermediates.
Canrenone (C). 1.41. 181 ng/mL at 4.3 hr. 16.5 hr (6.3) (terminal). ... Canrenone, a major (and active) metabolite of spironolactone, appears in human breast milk. Because spironolactone has been ... canrenone, is also a major product of spironolactone in man) for a period of one year. In two year studies in the rat, oral ...
Nursing mothers: Canrenone, a major (and active) metabolite of spironolactone, appears in human breast milk. Because ... canrenone, is also a major product of spironolactone in man) for a period of one year. In two-year studies in the rat, oral ...
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Canrenone, a major (and active) metabolite of spironolactone, appears in human breast milk. Because spironolactone has been ... canrenone, is also a major product of spironolactone in man) for a period of one year. In two-year studies in the rat, oral ...
Canrenone. increased. Spironolactone increases the level of Canrenone in the blood. *444376 ...
Canrenone. The risk or severity of adverse effects can be increased when Canrenone is combined with Mineral oil.. ...
... and canrenone (the 1,2-didehydro analogue of SC-5233). Spironolactone is a derivative of SC-5233 with a 7α-acetylthio group ( ... canrenone (SC-9376; Cantaren, Luvion), potassium canrenoate (SC-14266; Venactone, Soldactone), eplerenone (SC-66110, CGP-30083 ...
Minearlocorticoids (spironolactone, canrenone). Prostaglandin. *World number one. *Development of pulmonary arterial ...
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Aldosterone Antagonist Overview ,Spironolactone , Eplerenone , Potassium canrenoate , Canrenone. Antiplatelet Agents. ... Spironolactone]] , [[Eplerenone]] , [[Potassium canrenoate]] , [[Canrenone]],/small,. +. :,small,. Aldosterone Antagonist [[ ...
  • Plasma samples were analyzed by HPLC for determination of canrenone (the major metabolite and pharmacologically active moiety) and the data subjected to pharmacokinetic analysis using NONMEM. (aston.ac.uk)
  • Hepatic disposition may also be important in the toxicity of SP, because the parent compound prevents the hepatocarcinogenic effects of its metabolite, canrenone (CAN). (aspetjournals.org)
  • At other times you have a limited range of frequencies over which resting pressure exceeds that of plasma and erythrocyte sedimentation unless the disease lightly, knowing that her episodes of personality traits in the [h+] of blood ph and its active metabolite, canrenone (t 17 hr). (bigsurlandtrust.org)
  • AASraw adalah dengan sintesis dan keupayaan pengeluaran dari gram kepada urutan massal 11α-Hydroxy canrenone methacrylate Powder (192704-56-6), di bawah peraturan CGMP dan sistem kawalan kualiti yang boleh dikesan. (aasraw.com)
  • AASraw iko na muundo na uwezo wa uzalishaji kutoka gramu hadi agizo la misa ya 11α-Hydroxy canrenone methacrylate Powder (192704-56-6), chini ya kanuni ya CGMP na mfumo wa udhibiti wa ubora unaofuatilia. (aasraw.com)
  • The final population models for canrenone clearance (CL/F) and volume of distribution (V/F) were CL/F (l h −1 ) = 11.4 × (WT/70.0) 0.75 and V/F (l) = 374.2 × (WT/70) where WT is in kg. (aston.ac.uk)
  • Leprotic action of neuroleptics is weak while that canrenone is ~17 hours. (creativecall.org)
  • citation needed] Canrenone has been found to be effective in the treatment of hirsutism in women. (wikipedia.org)