AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsNamed GroupsHealth Care
CandidiasisCandidiasis, OralCandidiasis, VulvovaginalCandidiasis, InvasiveCandidiasis, CutaneousCandida albicansCandidiasis, Chronic MucocutaneousCandidaAntifungal AgentsFluconazoleAntibodies, FungalPharyngeal DiseasesEsophageal DiseasesEchinocandinsAntigens, FungalOropharynxAmphotericin BSugar AlcoholsFungal VaccinesClotrimazoleFungemiaLipopeptidesCandidemiaCandida glabrataDrug Resistance, FungalVaginaAIDS-Related Opportunistic InfectionsMannansCandida tropicalisVaginitisMiconazoleMouth DiseasesPeptides, CyclicMouth Mucosabeta-GlucansDiaper RashPolyendocrinopathies, AutoimmuneVaginal DiseasesTongueMice, Inbred ICRAspergillosisVulvovaginitisHyphaeColony Count, MicrobialMicrobial Sensitivity TestsVaginosis, BacterialItraconazoleMycosesTriazolesImmunocompromised HostFungal ProteinsPrecipitinsCentral Nervous System Fungal InfectionsNystatinAzolesNeutropeniaMycologyMouthDisease Models, AnimalAspartic Acid ProteasesOpportunistic InfectionsVaginal DischargeSplenic DiseasesLeukoplakia, HairyTrichomonas VaginitisKetoconazoleIndenesAgeusiaVirulenceHistatinsMucous MembraneDNA, FungalMice, Inbred BALB CKidneyFlucytosineDisease SusceptibilityFusariosisCryptococcosisStomatitis, DentureDenturesMenthaMice, Inbred CBAAspartic Acid EndopeptidasesAgranulocytosisLung Diseases, FungalStomach DiseasesHIV InfectionsGerm-Free LifeIntensive Care Units, NeonatalAdministration, OralRecurrenceTea Tree OilBoric AcidsCD4 Lymphocyte CountInfant, Extremely Low Birth WeightEsophagitisInfant, Premature, DiseasesLatex Fixation TestsInfant, NewbornAgglutinins
Candidiasis
Infection with a fungus of the genus CANDIDA. It is usually a superficial infection of the moist areas of the body and is generally caused by CANDIDA ALBICANS. (Dorland, 27th ed)
Candidiasis, Oral
Infection of the mucous membranes of the mouth by a fungus of the genus CANDIDA. (Dorland, 27th ed)
Candidiasis, Vulvovaginal
Infection of the VULVA and VAGINA with a fungus of the genus CANDIDA.
Candidiasis, Invasive
An important nosocomial fungal infection with species of the genus CANDIDA, most frequently CANDIDA ALBICANS. Invasive candidiasis occurs when candidiasis goes beyond a superficial infection and manifests as CANDIDEMIA, deep tissue infection, or disseminated disease with deep organ involvement.
Candidiasis, Cutaneous
Candidiasis of the skin manifested as eczema-like lesions of the interdigital spaces, perleche, or chronic paronychia. (Dorland, 27th ed)
Candida albicans
A unicellular budding fungus which is the principal pathogenic species causing CANDIDIASIS (moniliasis).
Candidiasis, Chronic Mucocutaneous
A clinical syndrome characterized by development, usually in infancy or childhood, of a chronic, often widespread candidiasis of skin, nails, and mucous membranes. It may be secondary to one of the immunodeficiency syndromes, inherited as an autosomal recessive trait, or associated with defects in cell-mediated immunity, endocrine disorders, dental stomatitis, or malignancy.
Candida
A genus of yeast-like mitosporic Saccharomycetales fungi characterized by producing yeast cells, mycelia, pseudomycelia, and blastophores. It is commonly part of the normal flora of the skin, mouth, intestinal tract, and vagina, but can cause a variety of infections, including CANDIDIASIS; ONYCHOMYCOSIS; vulvovaginal candidiasis (CANDIDIASIS, VULVOVAGINAL), and thrush (see CANDIDIASIS, ORAL). (From Dorland, 28th ed)
Antifungal Agents
Substances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues.
Fluconazole
Triazole antifungal agent that is used to treat oropharyngeal CANDIDIASIS and cryptococcal MENINGITIS in AIDS.
Antibodies, Fungal
Immunoglobulins produced in a response to FUNGAL ANTIGENS.
Pharyngeal Diseases
Pathological processes involving the PHARYNX.
Esophageal Diseases
Pathological processes in the ESOPHAGUS.
Echinocandins
Cyclic hexapeptides of proline-ornithine-threonine-proline-threonine-serine. The cyclization with a single non-peptide bond can lead them to be incorrectly called DEPSIPEPTIDES, but the echinocandins lack ester links. Antifungal activity is via inhibition of 1,3-beta-glucan synthase production of BETA-GLUCANS.
Antigens, Fungal
Substances of fungal origin that have antigenic activity.
Oropharynx
The middle portion of the pharynx that lies posterior to the mouth, inferior to the SOFT PALATE, and superior to the base of the tongue and EPIGLOTTIS. It has a digestive function as food passes from the mouth into the oropharynx before entering ESOPHAGUS.
Amphotericin B
Macrolide antifungal antibiotic produced by Streptomyces nodosus obtained from soil of the Orinoco river region of Venezuela.
Sugar Alcohols
Polyhydric alcohols having no more than one hydroxy group attached to each carbon atom. They are formed by the reduction of the carbonyl group of a sugar to a hydroxyl group.(From Dorland, 28th ed)
Fungal Vaccines
Suspensions of attenuated or killed fungi administered for the prevention or treatment of infectious fungal disease.
Clotrimazole
An imidazole derivative with a broad spectrum of antimycotic activity. It inhibits biosynthesis of the sterol ergostol, an important component of fungal CELL MEMBRANES. Its action leads to increased membrane permeability and apparent disruption of enzyme systems bound to the membrane.
Fungemia
The presence of fungi circulating in the blood. Opportunistic fungal sepsis is seen most often in immunosuppressed patients with severe neutropenia or in postoperative patients with intravenous catheters and usually follows prolonged antibiotic therapy.
Lipopeptides
Compounds consisting of a short peptide chain conjugated with an acyl chain.
Candidemia
A form of invasive candidiasis where species of CANDIDA are present in the blood.
Candida glabrata
A species of MITOSPORIC FUNGI commonly found on the body surface. It causes opportunistic infections especially in immunocompromised patients.
Drug Resistance, Fungal
The ability of fungi to resist or to become tolerant to chemotherapeutic agents, antifungal agents, or antibiotics. This resistance may be acquired through gene mutation.
Vagina
The genital canal in the female, extending from the UTERUS to the VULVA. (Stedman, 25th ed)
AIDS-Related Opportunistic Infections
Opportunistic infections found in patients who test positive for human immunodeficiency virus (HIV). The most common include PNEUMOCYSTIS PNEUMONIA, Kaposi's sarcoma, cryptosporidiosis, herpes simplex, toxoplasmosis, cryptococcosis, and infections with Mycobacterium avium complex, Microsporidium, and Cytomegalovirus.
Mannans
Polysaccharides consisting of mannose units.
Candida tropicalis
A species of MITOSPORIC FUNGI that is a major cause of SEPTICEMIA and disseminated CANDIDIASIS, especially in patients with LYMPHOMA; LEUKEMIA; and DIABETES MELLITUS. It is also found as part of the normal human mucocutaneous flora.
Vaginitis
Inflammation of the vagina characterized by pain and a purulent discharge.
Miconazole
An imidazole antifungal agent that is used topically and by intravenous infusion.
Mouth Diseases
Peptides, Cyclic
Peptides whose amino and carboxy ends are linked together with a peptide bond forming a circular chain. Some of them are ANTI-INFECTIVE AGENTS. Some of them are biosynthesized non-ribosomally (PEPTIDE BIOSYNTHESIS, NON-RIBOSOMAL).
Mouth Mucosa
Lining of the ORAL CAVITY, including mucosa on the GUMS; the PALATE; the LIP; the CHEEK; floor of the mouth; and other structures. The mucosa is generally a nonkeratinized stratified squamous EPITHELIUM covering muscle, bone, or glands but can show varying degree of keratinization at specific locations.
beta-Glucans
Glucose polymers consisting of a backbone of beta(1->3)-linked beta-D-glucopyranosyl units with beta(1->6) linked side chains of various lengths. They are a major component of the CELL WALL of organisms and of soluble DIETARY FIBER.
Diaper Rash
A type of irritant dermatitis localized to the area in contact with a diaper and occurring most often as a reaction to prolonged contact with urine, feces, or retained soap or detergent.
Polyendocrinopathies, Autoimmune
Autoimmune diseases affecting multiple endocrine organs. Type I is characterized by childhood onset and chronic mucocutaneous candidiasis (CANDIDIASIS, CHRONIC MUCOCUTANEOUS), while type II exhibits any combination of adrenal insufficiency (ADDISON'S DISEASE), lymphocytic thyroiditis (THYROIDITIS, AUTOIMMUNE;), HYPOPARATHYROIDISM; and gonadal failure. In both types organ-specific ANTIBODIES against a variety of ENDOCRINE GLANDS have been detected. The type II syndrome differs from type I in that it is associated with HLA-A1 and B8 haplotypes, onset is usually in adulthood, and candidiasis is not present.
Vaginal Diseases
Pathological processes of the VAGINA.
Tongue
A muscular organ in the mouth that is covered with pink tissue called mucosa, tiny bumps called papillae, and thousands of taste buds. The tongue is anchored to the mouth and is vital for chewing, swallowing, and for speech.
Mice, Inbred ICR
Aspergillosis
Infections with fungi of the genus ASPERGILLUS.
Vulvovaginitis
Inflammation of the VULVA and the VAGINA, characterized by discharge, burning, and PRURITUS.
Hyphae
Microscopic threadlike filaments in FUNGI that are filled with a layer of protoplasm. Collectively, the hyphae make up the MYCELIUM.
Colony Count, Microbial
Enumeration by direct count of viable, isolated bacterial, archaeal, or fungal CELLS or SPORES capable of growth on solid CULTURE MEDIA. The method is used routinely by environmental microbiologists for quantifying organisms in AIR; FOOD; and WATER; by clinicians for measuring patients' microbial load; and in antimicrobial drug testing.
Microbial Sensitivity Tests
Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses).
Vaginosis, Bacterial
Polymicrobial, nonspecific vaginitis associated with positive cultures of Gardnerella vaginalis and other anaerobic organisms and a decrease in lactobacilli. It remains unclear whether the initial pathogenic event is caused by the growth of anaerobes or a primary decrease in lactobacilli.
Itraconazole
A triazole antifungal agent that inhibits cytochrome P-450-dependent enzymes required for ERGOSTEROL synthesis.
Mycoses
Triazoles
Immunocompromised Host
A human or animal whose immunologic mechanism is deficient because of an immunodeficiency disorder or other disease or as the result of the administration of immunosuppressive drugs or radiation.
Fungal Proteins
Proteins found in any species of fungus.
Precipitins
Antibodies which elicit IMMUNOPRECIPITATION when combined with antigen.
Central Nervous System Fungal Infections
MYCOSES of the brain, spinal cord, and meninges which may result in ENCEPHALITIS; MENINGITIS, FUNGAL; MYELITIS; BRAIN ABSCESS; and EPIDURAL ABSCESS. Certain types of fungi may produce disease in immunologically normal hosts, while others are classified as opportunistic pathogens, causing illness primarily in immunocompromised individuals (e.g., ACQUIRED IMMUNODEFICIENCY SYNDROME).
Nystatin
Macrolide antifungal antibiotic complex produced by Streptomyces noursei, S. aureus, and other Streptomyces species. The biologically active components of the complex are nystatin A1, A2, and A3.
Azoles
Five membered rings containing a NITROGEN atom.
Neutropenia
A decrease in the number of NEUTROPHILS found in the blood.
Mycology
The study of the structure, growth, function, genetics, and reproduction of fungi, and MYCOSES.
Mouth
The oval-shaped oral cavity located at the apex of the digestive tract and consisting of two parts: the vestibule and the oral cavity proper.
Disease Models, Animal
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
Aspartic Acid Proteases
A subclass of peptide hydrolases that depend on an ASPARTIC ACID residue for their activity.
Opportunistic Infections
An infection caused by an organism which becomes pathogenic under certain conditions, e.g., during immunosuppression.
Vaginal Discharge
A common gynecologic disorder characterized by an abnormal, nonbloody discharge from the genital tract.
Splenic Diseases
Leukoplakia, Hairy
Epithelial hyperplasia of the oral mucosa associated with Epstein-Barr virus (HERPESVIRUS 4, HUMAN) and found almost exclusively in persons with HIV infection. The lesion consists of a white patch that is often corrugated or hairy.
Trichomonas Vaginitis
Inflammation of the vagina, marked by a purulent discharge. This disease is caused by the protozoan TRICHOMONAS VAGINALIS.
Ketoconazole
Broad spectrum antifungal agent used for long periods at high doses, especially in immunosuppressed patients.
Indenes
A family of fused-ring hydrocarbons isolated from coal tar that act as intermediates in various chemical reactions and are used in the production of coumarone-indene resins.
Ageusia
Complete or severe loss of the subjective sense of taste, frequently accompanied by OLFACTION DISORDERS.
Virulence
The degree of pathogenicity within a group or species of microorganisms or viruses as indicated by case fatality rates and/or the ability of the organism to invade the tissues of the host. The pathogenic capacity of an organism is determined by its VIRULENCE FACTORS.
Histatins
A group of small, histidine-rich, cationic peptides in human SALIVA which are antibacterial and antifungal.
Mucous Membrane
An EPITHELIUM with MUCUS-secreting cells, such as GOBLET CELLS. It forms the lining of many body cavities, such as the DIGESTIVE TRACT, the RESPIRATORY TRACT, and the reproductive tract. Mucosa, rich in blood and lymph vessels, comprises an inner epithelium, a middle layer (lamina propria) of loose CONNECTIVE TISSUE, and an outer layer (muscularis mucosae) of SMOOTH MUSCLE CELLS that separates the mucosa from submucosa.
DNA, Fungal
Deoxyribonucleic acid that makes up the genetic material of fungi.
Mice, Inbred BALB C
Kidney
Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.
Flucytosine
A fluorinated cytosine analog that is used as an antifungal agent.
Disease Susceptibility
A constitution or condition of the body which makes the tissues react in special ways to certain extrinsic stimuli and thus tends to make the individual more than usually susceptible to certain diseases.
Fusariosis
OPPORTUNISTIC INFECTIONS with the soil fungus FUSARIUM. Typically the infection is limited to the nail plate (ONYCHOMYCOSIS). The infection can however become systemic especially in an IMMUNOCOMPROMISED HOST (e.g., NEUTROPENIA) and results in cutaneous and subcutaneous lesions, fever, KERATITIS, and pulmonary infections.
Cryptococcosis
Infection with a fungus of the species CRYPTOCOCCUS NEOFORMANS.
Stomatitis, Denture
Inflammation of the mouth due to denture irritation.
Dentures
An appliance used as an artificial or prosthetic replacement for missing teeth and adjacent tissues. It does not include CROWNS; DENTAL ABUTMENTS; nor TOOTH, ARTIFICIAL.
Mentha
Mentha is a genus of the mint family (LAMIACEAE). It is known for species having characteristic flavor and aroma.
Mice, Inbred CBA
Aspartic Acid Endopeptidases
A sub-subclass of endopeptidases that depend on an ASPARTIC ACID residue for their activity.
Agranulocytosis
A decrease in the number of GRANULOCYTES; (BASOPHILS; EOSINOPHILS; and NEUTROPHILS).
Lung Diseases, Fungal
Pulmonary diseases caused by fungal infections, usually through hematogenous spread.
Stomach Diseases
Pathological processes involving the STOMACH.
HIV Infections
Includes the spectrum of human immunodeficiency virus infections that range from asymptomatic seropositivity, thru AIDS-related complex (ARC), to acquired immunodeficiency syndrome (AIDS).
Germ-Free Life
Animals not contaminated by or associated with any foreign organisms.
Intensive Care Units, Neonatal
Hospital units providing continuing surveillance and care to acutely ill newborn infants.
Administration, Oral
The giving of drugs, chemicals, or other substances by mouth.
Recurrence
The return of a sign, symptom, or disease after a remission.
Tea Tree Oil
Essential oil extracted from Melaleuca alternifolia (tea tree). It is used as a topical antimicrobial due to the presence of terpineol.
Boric Acids
Inorganic and organic derivatives of boric acid either B(OH)3 or, preferably H3BO3.
CD4 Lymphocyte Count
The number of CD4-POSITIVE T-LYMPHOCYTES per unit volume of BLOOD. Determination requires the use of a fluorescence-activated flow cytometer.
Infant, Extremely Low Birth Weight
An infant whose weight at birth is less than 1000 grams (2.2 lbs), regardless of GESTATIONAL AGE.
Esophagitis
INFLAMMATION, acute or chronic, of the ESOPHAGUS caused by BACTERIA, chemicals, or TRAUMA.
Infant, Premature, Diseases
Latex Fixation Tests
Passive agglutination tests in which antigen is adsorbed onto latex particles which then clump in the presence of antibody specific for the adsorbed antigen. (From Stedman, 26th ed)
Infant, Newborn
An infant during the first month after birth.
Agglutinins
Substances, usually of biological origin, that cause cells or other organic particles to aggregate and stick to each other. They include those ANTIBODIES which cause aggregation or agglutination of particulate or insoluble ANTIGENS.
Gastrointestinal Diseases
Diseases in any segment of the GASTROINTESTINAL TRACT from ESOPHAGUS to RECTUM.
Drug Resistance, Microbial
The ability of microorganisms, especially bacteria, to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).
Immunosuppression
Deliberate prevention or diminution of the host's immune response. It may be nonspecific as in the administration of immunosuppressive agents (drugs or radiation) or by lymphocyte depletion or may be specific as in desensitization or the simultaneous administration of antigen and immunosuppressive drugs.
Mycological Typing Techniques
Procedures for identifying types and strains of fungi.
Vaginal Douching
The washing of the VAGINA cavity or surface with a solution. Agents or drugs can be added to the irrigation solution.
Treatment Outcome
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Meningitis, Fungal
Meningitis caused by fungal agents which may occur as OPPORTUNISTIC INFECTIONS or arise in immunocompetent hosts.
Cortisone
A naturally occurring glucocorticoid. It has been used in replacement therapy for adrenal insufficiency and as an anti-inflammatory agent. Cortisone itself is inactive. It is converted in the liver to the active metabolite HYDROCORTISONE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p726)
Melaleuca
A plant genus of the family MYRTACEAE. M. alternifolia foliage is a source of TEA TREE OIL. The common name of tea tree also refers to LEPTOSPERMUM or KUNZEA. M. vindifolia is a source of niaouli oil. M. cajuputi and M. leucadendra are sources of cajuput oil.
Tongue Diseases
Saliva
The clear, viscous fluid secreted by the SALIVARY GLANDS and mucous glands of the mouth. It contains MUCINS, water, organic salts, and ptylin.
Cassia
A plant genus of the family FABACEAE. Many species of this genus, including the medicinal C. senna and C. angustifolia, have been reclassified into the Senna genus (SENNA PLANT) and some to CHAMAECRISTA.
Cinnamomum aromaticum
A plant species of the genus CINNAMOMUM that contains CINNAMATES and has been used in traditional Chinese medicine (DRUGS, CHINESE HERBAL).
Sensitivity and Specificity
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
Esophagus
The muscular membranous segment between the PHARYNX and the STOMACH in the UPPER GASTROINTESTINAL TRACT.
Geranium
A plant genus of the family GERANIACEAE. Geranium is also used as a common name for PELARGONIUM.
Counterimmunoelectrophoresis
Immunoelectrophoresis in which immunoprecipitation occurs when antigen at the cathode is caused to migrate in an electric field through a suitable medium of diffusion against a stream of antibody migrating from the anode as a result of endosmotic flow.
Immunocompetence
The ability of lymphoid cells to mount a humoral or cellular immune response when challenged by antigen.

Incidence and predictors of invasive candidiasis associated with candidaemia in children. (1/75)

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High ferritin levels are associated with hepatosplenic candidiasis in hematopoietic stem cell transplant candidates. (2/75)

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Prediction of the clinical outcome in invasive candidiasis patients based on molecular fingerprints of five anti-Candida antibodies in serum. (3/75)

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Endosomal and AP-3-dependent vacuolar trafficking routes make additive contributions to Candida albicans hyphal growth and pathogenesis. (4/75)

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Prospective survey of (1-->3)-beta-D-glucan and its relationship to invasive candidiasis in the surgical intensive care unit setting. (5/75)

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Organ-specific innate immune responses in a mouse model of invasive candidiasis. (6/75)

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PCR diagnosis of invasive candidiasis: systematic review and meta-analysis. (7/75)

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The use of mannan antigen and anti-mannan antibodies in the diagnosis of invasive candidiasis: recommendations from the Third European Conference on Infections in Leukemia. (8/75)

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The continuous changes in the aetiology and epidemiology of invasive candidiasis: from familiar Candida albicans to...The continuous changes in the aetiology and epidemiology of invasive candidiasis: from familiar Candida albicans to...
Recent changes in the aetiology and epidemiology of invasive candidiasis have serious implications for current and future diagnosis, treatment and prognosis. The aim of the current review was to discuss the epidemiology of invasive candidiasis, the distribution of Candida species in different regions of the world, the medical concerns of the changing aetiology and the emergence of antifungal resistance. Overall burden of invasive candidiasis remains high, especially in vulnerable persons, such as the elderly, immunosuppressed or debilitated patients. Moreover, there is a progressive shift in the aetiology of invasive candidiasis from Candida albicans to other species of Candida, probably related to the increased use of azole drugs with a clear trend towards increased antifungal resistance. Finally, the emergence and rise of multiresistant species, such as Candida auris or Candida glabrata, is a major threat making necessary invasive candidiasis worldwide surveillances. These changes have serious ...
http://www.ehu.eus/ehusfera/mikrobios/2018/07/08/the-continuous-changes-in-the-aetiology-and-epidemiology-of-invasive-candidiasis-from-familiar-candida-albicans-to-multiresistant-candida-auris/
Comparison of the incidence, clinical features and outcomes of invasive candidiasis in children and neonates | BMC Infectious...Comparison of the incidence, clinical features and outcomes of invasive candidiasis in children and neonates | BMC Infectious...
Invasive candidiasis differs greatly between children and neonates. We aimed to investigate the different therapeutic approaches and their effects on treatment outcomes of these two groups. Episodes of neonatal invasive candidiasis were compared with non-neonatal pediatric episodes during a 12-year cohort study. Clinical isolates were documented by matrix-assisted laser desorption/ionization-time of flight mass spectrometry and DNA sequencing, and antifungal susceptibility testing was performed. A total of 342 episodes of invasive candidiasis (113 neonatal and 229 non-neonatal pediatric episodes) in 281 pediatric patients (96 neonates and 185 children) were identified. Candida albicans was the most common pathogen causing invasive candidiasis in neonates and children (47.8% vs. 44.1%). The antifungal susceptibility profiles were not significantly different between neonates and children. More neonates received amphotericin B as therapy, whereas more children received fluconazole or caspofungin. Compared
https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-018-3100-2/figures/2
T2Candida Diagnostic Test for ICU Patients at Risk for Invasive Candidiasis - Healthier Environment Living Program
Although the diagnostic performance for all tests were modest in regards to the detection of invasive candidiasis in patients in a high-risk intensive care unit (ICU), the combination of the new test T2Candida and blood culture seemed to have the best performance, according to a study published in Open Forum Infectious Diseases.. Blood culture is the gold standard test for invasive candidiasis, comprising candidemia and deep-seated candidiasis, but the sensitivity of this test is low. The average time to blood culture positivity is approximately 2 days, and some studies have associated a 2-day antifungal therapy delay with a more than doubled mortality rate. There is, therefore, a need for rapid diagnostic testing in invasive candidiasis.. ...
https://healthybuilds.com/t2candida-diagnostic-test-for-icu-patients-at-risk-for-invasive-candidiasis/
Anidulafungin compared with fluconazole in severely ill patients with candidemia and other forms of invasive candidiasis:...
TY - JOUR. T1 - Anidulafungin compared with fluconazole in severely ill patients with candidemia and other forms of invasive candidiasis. T2 - Support for the 2009 IDSA treatment guidelines for candidiasis. AU - Kett, Daniel H.. AU - Shorr, Andrew F.. AU - Reboli, Annette C.. AU - Reisman, Arlene L.. AU - Biswas, Pinaki. AU - Schlamm, Haran T.. PY - 2011/10/25. Y1 - 2011/10/25. N2 - Introduction: During the past decade, the incidence of Candida infections in hospitalized patients has increased, with fluconazole being the most commonly prescribed systemic antifungal agent for these infections. However, the 2009 Infectious Diseases Society of America (IDSA) candidiasis guidelines recommend an echinocandin for the treatment of candidemia/invasive candidiasis in patients who are considered to be moderately severe or severely ill. To validate these guidelines, clinical trial data were reviewed.Methods: A secondary analysis of data from a previously published prospective, randomized, double-blind ...
https://miami.pure.elsevier.com/en/publications/anidulafungin-compared-with-fluconazole-in-severely-ill-patients-
Multicenter retrospective development and validation of a clinical prediction rule for nosocomial invasive candidiasis in the...Multicenter retrospective development and validation of a clinical prediction rule for nosocomial invasive candidiasis in the...
The study presented here was performed in order to create a rule that identifies subjects at high risk for invasive candidiasis in the intensive care setting. Retrospective review and statistical modelling were carried out on 2,890 patients who stayed at least 4 days in nine hospitals in the USA and Brazil; the overall incidence of invasive candidiasis in this group was 3% (88 cases).
https://www.rti.org/publication/multicenter-retrospective-development-and-validation-clinical-prediction-rule-nosocomial
Epidemiology of Hospitalizations Associated with Invasive Candidiasis, United States, 2002-2012 - Volume 23, Number 1-January...
Invasive candidiasis is a major nosocomial fungal disease in the United States associated with high rates of illness and death. We analyzed inpatient hospitalization records from the Healthcare Cost and Utilization Project to estimate incidence of invasive candidiasis-associated hospitalizations in the United States. We extracted data for 33 states for 2002-2012 by using codes from the International Classification of Diseases, 9th Revision, Clinical Modification, for invasive candidiasis; we excluded neonatal cases. The overall age-adjusted average annual rate was 5.3 hospitalizations/100,000 population. Highest risk was for adults >65 years of age, particularly men. Median length of hospitalization was 21 days; 22% of patients died during hospitalization. Median unadjusted associated cost for inpatient care was $46,684. Age-adjusted annual rates decreased during 2005-2012 for men (annual change -3.9%) and women (annual change -4.5%) and across nearly all age groups. We report a high mortality
https://wwwnc.cdc.gov/eid/article/23/1/16-1198_article
Attributable mortality and Costs of Invasive Candida Infections in European hospitals | ECMMAttributable mortality and Costs of Invasive Candida Infections in European hospitals | ECMM
The title of the study will be Attributable mortality and Costs of Invasive Candida Infections in European hospitals: a prospective case-control study, and the study as well as the working group will be lead by PD Martin Hoenigl and Prof. Oliver Cornely. The case-control study will focus on evaluating attributable mortality and costs as well as diagnostic and therapeutic approaches (including prolonged hospital stay for completion of parenteral antifungal treatment) of nosocomial IC infections in Europe. As a secondary objective we will evaluate antifungal resistance among Candida spp. causing invasive diseases across Europe. In addition, the case control design will allow for implementation of health economic analyses on the incremental costs associated with IC infections ...
https://www.ecmm.info/working-groups/2219/
Ecalta (anidulafungin) Recommended For Use In NHS Scotland - Antifungal For Invasive CandidiasisEcalta (anidulafungin) Recommended For Use In NHS Scotland - Antifungal For Invasive Candidiasis
Pfizer Limited today welcomes the Scottish Medicines Consortium (SMC) advice, which recommends Ecalta (anidulafungin), a new antifungal medicine for the treatment of invasive candidiasis in NHS Scotland.1 Following a re-submission, the SMCs decision to recommend anidulafungin comes after results of the cost-minimisation analysis which indicated that anidulafungin would be preferred to both caspofungin and liposomal amphotericin B, with savings of 772 and 2,375 respectively, as a
https://www.meduweb.com/showthread.php/3988-Ecalta-
Cost-effectiveness analysis of anidulafungin for the treatment of candidaemia and other forms of invasive candidiasis | BMC...Cost-effectiveness analysis of anidulafungin for the treatment of candidaemia and other forms of invasive candidiasis | BMC...
Candidaemia and other forms of invasive candidiasis (C/IC) in the intensive care unit are challenging conditions that are associated with high rates of mortality. New guidelines from the European Society for Clinical Microbiology and Infectious Diseases strongly recommend echinocandins for the first-line treatment of C/IC. Here, a cost-effectiveness model was developed from the United Kingdom perspective to examine the costs and outcomes of antifungal treatment for C/IC based on the European Society for Clinical Microbiology and Infectious Diseases guidelines. Costs and treatment outcomes with the echinocandin anidulafungin were compared with those for caspofungin, micafungin and fluconazole. The model included non-neutropenic patients aged ≥16 years with confirmed C/IC who were receiving intravenous first-line treatment. Patients were categorised as either a clinical success or failure (patients with persistent/breakthrough infection); successfully treated patients switched to oral therapy, while
https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-015-1143-1/tables/3
Notes from Dr. RW: Updated guidelines for the treatment of candida infectionsNotes from Dr. RW: Updated guidelines for the treatment of candida infections
28. Empiric antifungal therapy should be considered in critically ill patients with risk factors for invasive candidiasis and no other known cause of fever and should be based on clinical assessment of risk factors, surrogate markers for invasive candidiasis, and/or culture data from nonsterile sites (strong recommendation; moderate-quality evidence). Empiric antifungal therapy should be started as soon as possible in patients who have the above risk factors and who have clinical signs of septic shock (strong recommendation; moderate-quality evidence). ...
http://doctorrw.blogspot.com/2016/01/updated-guidelines-for-treatment-of.html
A Study of Caspofungin Acetate (MK0991) for the Treatment of Esophageal Candidiasis or Invasive Candidiasis in Chinese Adults ...A Study of Caspofungin Acetate (MK0991) for the Treatment of Esophageal Candidiasis or Invasive Candidiasis in Chinese Adults ...
A Study of Caspofungin Acetate (MK0991) for the Treatment of Esophageal Candidiasis or Invasive Candidiasis in Chinese Adults (MK-0991-066 ...
https://clinicaltrials.gov/ct2/keydates/NCT00635648
Isavuconazole designated QIDP in the US for the treatment of invasive candidiasis, Basilea seeks additional approval in EU for...Isavuconazole designated QIDP in the US for the treatment of invasive candidiasis, Basilea seeks additional approval in EU for...
A QIDP designation, granted under the U.S. GAIN Act, provides priority review and a five-year extension of market exclusivity, should the product be approved in the United States. Isavuconazole was previously granted QIDP designation for the treatment of invasive aspergillosis and invasive mucormycosis (also known as zygomycosis), which are severe mold infections. In addition, isavuconazole has FDA fast-track status and received U.S. and European Union orphan drug designations for invasive aspergillosis and mucormycosis.. Prof. Achim Kaufhold, Basileas Chief Medical Officer, commented: Invasive candidiasis is a nosocomial infection associated with high mortality, frequently occurring in critically ill patients, such as cancer patients undergoing chemotherapy, organ transplantation, and invasive surgical procedures. Moreover, the incidence of Candida infections has been increasing over past decades. He added: We are very pleased that the FDA has granted this third QIDP designation to ...
http://outbreaknewstoday.com/isavuconazole-designated-qidp-in-the-us-for-the-treatment-of-invasive-candidiasis-basilea-seeks-additional-approval-in-eu-for-treatment-of-invasive-mold-infections-58206/
Full text] Epidemiology and risk factors for invasive candidiasis | TCRMFull text] Epidemiology and risk factors for invasive candidiasis | TCRM
Epidemiology and risk factors for invasive candidiasis Nur Yapar Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Dokuz Eylül University, İzmir, Turkey Abstract: The number of immunosuppressive patients has increased significantly in recent years. These patients are at risk for opportunistic infections, especially fungal infections. Candidiasis is one of the most frequent fungal infections determined in these immunosuppressive patients and its epidemiology has changed over the last two decades. Recently, new antifungal agents and new therapy strategies such as antifungal prophylaxis, secondary prophylaxis, and preemptive therapy have come into use. These changes resulted in the alteration of Candida species causing invasive infections. The incidence of Candida albicans was decreased in many countries, especially among patients with immunosuppressive disorders, while the incidence of species other than C. albicans was increased. In this review, incidence, risk
https://www.dovepress.com/epidemiology-and-risk-factors-for-invasive-candidiasis-peer-reviewed-fulltext-article-TCRM
Recent Advances in the Management of Invasive Candidiasis | SpringerLinkRecent Advances in the Management of Invasive Candidiasis | SpringerLink
Viscoli, C. Recent Advances in the Management of Invasive Candidiasis. Drugs 69, 1-3 (2009). https://doi.org/10.2165/11315490-000000000-00000. Download ...
https://link.springer.com/article/10.2165%2F11315490-000000000-00000
Evaluation of Candida score in critically ill patients: a prospective, multicenter, observational, cohort study | Annals of...Evaluation of Candida score in critically ill patients: a prospective, multicenter, observational, cohort study | Annals of...
Although prompt initiation of appropriate antifungal therapy is essential for the control of invasive Candida infections and an improvement of prognosis, early diagnosis of invasive candidiasis remains a challenge and criteria for starting empirical antifungal therapy in ICU patients are poorly defined. Some scoring systems, such as the Candida score could help physicians to differentiate patients who could benefit from early antifungal treatment from those for whom invasive candidiasis is highly improbable. This study evaluated the performance of this score in a cohort of critically ill patients. A prospective, observational, multicenter, cohort study was conducted from January 2010 to March 2011 in five intensive care units in Nord-Pas de Calais, an area from North of France. All patients exhibiting, on ICU admission or during their ICU stay, a hospital-acquired severe sepsis or septic shock could be included in this study. The data collected included patient characteristics on ICU admission and at
https://annalsofintensivecare.springeropen.com/articles/10.1186/2110-5820-1-50/tables/3
BIOPIC: Fungal Biomarkers for Diagnosis and Response to Therapy for Pediatric Candidemia - Full Text View - ClinicalTrials.govBIOPIC: Fungal Biomarkers for Diagnosis and Response to Therapy for Pediatric Candidemia - Full Text View - ClinicalTrials.gov
This study will create an international multi-center cohort of children with new clinical concern for infection while in the hospital. Sites used are part of the International Pediatric Fungal Network (ipfn.org). The study plans to prospectively enroll pediatric patients at high-risk of developing invasive candidiasis over a four year period. The study duration per subject will be up to 14 days for blood collection and 30 days for data collection from the medical record.. For the first aim, this study will assemble a prospective cohort of pediatric patients at high-risk for developing invasive candidiasis. Blood samples for biomarker testing will be obtained within 24-hours of a patient having a clinical indication for blood culture attainment. To accomplish the second aim, additional blood sampling will be performed in the sub-set of patients that are found to have invasive candidiasis. For the third aim, remnant blood samples following biomarker testing from all consenting participants will be ...
https://clinicaltrials.gov/ct2/show/NCT02220790
Invasive Candida infections in the ICU - Eggimann - 2012 - Mycoses - Wiley Online LibraryInvasive Candida infections in the ICU - Eggimann - 2012 - Mycoses - Wiley Online Library
If you are a society or association member and require assistance with obtaining online access instructions please contact our Journal Customer Services team ...
http://onlinelibrary.wiley.com/doi/10.1111/j.1439-0507.2011.02151.x/pdf
The Perfect Stool Understanding and Healing the Gut Microbiome: Invasive Candidiasis with Dr. Kurt Woeller
Even the most symptomatic cases of candida are treatable! This otherwise normal fungal resident of our GI tract, when it becomes invasive, leads to a whole host of symptoms, including bloating, gas, constipation and other digestive issues, brain fog, drunken-like behavior in children, food sensitivities and leaky gut. Hear Dr. Kurt Woeller, DO explore the root causes of candidiasis, its connection to autism, how to test for it and treatments including probiotics, diet changes, prescription and herbal medications. Lindsey Parsons, your host, helps clients solve gut issues and reverse autoimmune disease naturally. Shes a Certified Health Coach at in Tucson, Arizona. She coaches clients locally and nationwide. You can also follow Lindsey on , , or or reach her via email at [email protected] to set up a free 30-minute .
https://theperfectstool.libsyn.com/invasive-candidiasis-with-dr-kurt-woeller
PCR Diagnosis of Invasive Candidiasis: Systematic Review and Meta-Analysis | Journal of Clinical MicrobiologyPCR Diagnosis of Invasive Candidiasis: Systematic Review and Meta-Analysis | Journal of Clinical Microbiology
Comment.Studies assessing patients with candidemia versus healthy controls showed that PCR of whole-blood samples targeting panfungal genes has 100% sensitivity and specificity. When patients with candidemia constituted the case definition and patients with sepsis at risk for IC without candidemia constituted the control group, the sensitivity was 100% in 31/49 studies and the pooled (HSROC) sensitivity was 0.95 (95% confidence interval, 0.88 to 0.98). As expected, sensitivity decreased as the reference standard became less stringent, from proven through probable to possible IC. In the analysis where patients with cases had proven/probable or possible IC and other patients at risk for IC were controls, the pooled (HSROC) sensitivity was 0.73 (0.58 to 0.83). The pooled specificity was above 90% in all analyses. In studies conducted after 2000, positive likelihood ratios were higher than those in older studies, ranging from 14 to 24 in the different analyses, and the negative likelihood ratio for ...
https://jcm.asm.org/content/49/2/665
IDWeek 2018: Using Blockchain to Develop a Novel Propensity Score for Candidemia and Invasive CandidiasisIDWeek 2018: Using Blockchain to Develop a Novel Propensity Score for Candidemia and Invasive Candidiasis
All opinions published on Op-Med are the authors and do not reflect the official position of Doximity or its editors. Op-Med is a safe space for free expression and diverse perspectives. For more information, or to submit your own opinion, please see our submission guidelines or email [email protected] ...
https://opmed.doximity.com/articles/idweek-2018-using-blockchain-to-develop-a-novel-propensity-score-for-candidemia-and-invasive-candidiasis?_csrf_attempted=yes
Caspofungin therapy of neonates with invasive candidiasis. - PubMed - NCBICaspofungin therapy of neonates with invasive candidiasis. - PubMed - NCBI
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
https://www.ncbi.nlm.nih.gov/pubmed/15626944?dopt=Abstract
A Novel Therapeutic for Invasive Candidiasis - Richard ScottA Novel Therapeutic for Invasive Candidiasis - Richard Scott
Systemic fungal infections are increasingly common, especially in immune compromised patients. While new antifungal drugs have been developed, there is still a...
http://grantome.com/grant/NIH/R44-AI106270-04A1
Epidemiology of Invasive Candidiasis: a Persistent Public Health Problem | Clinical Microbiology ReviewsEpidemiology of Invasive Candidiasis: a Persistent Public Health Problem | Clinical Microbiology Reviews
Thank you for sharing this Clinical Microbiology Reviews article.. NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.. ...
https://cmr.asm.org/content/20/1/133/article-info
Diagnosing Invasive Candidiasis | Journal of Clinical MicrobiologyDiagnosing Invasive Candidiasis | Journal of Clinical Microbiology
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https://jcm.asm.org/content/56/5/e01909-17/article-info
Candidiasis, Invasive | REACH
Steinbach WJ, Roilides E, Berman D, Hoffman JA, Groll AH, Bin-Hussain I, Palazzi DL, Castagnola E, Halasa N, Velegraki A, Dvorak CC, Charkabarti A, Sung L, Danziger-Isakov L, Lachenauer C, Arrieta A, Knapp K, Abzug MJ, Ziebold C, Lehrnbecher T, Klingspor L, Warris A, Leckerman K, Martling T, Walsh TJ, Benjamin DK, Zaoutis TE. Results from a prospective, international, epidemiologic study of invasive candidiasis in children and neonates. Pediatr Infect Dis J. 2012 Dec; 31(12):1252-7 ...
https://reach.sickkids.ca/display/4325
Cipro candida
Individuals at risk for invasive candidiasis include low birth weight babies, people recovering from surgery, people admitted to an intensive care units
https://www.genericonlineviagrarx.com/Canada+Pharmacies/cipro-candida-80-126
dimorphism | Infection and Immunitydimorphism | Infection and Immunity
Candida albicans dimorphism is a crucial virulence factor during invasive candidiasis infections, which claim the lives of nearly one-half of those afflicted. It has long been believed that filaments drive tissue invasion and yeast mediates bloodstream dissemination, but observation of these activities during infection has been prevented by technical limitations.... ...
https://iai.asm.org/keyword/dimorphism
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Internist/infectious Diseases Physician Salaries, Average Salary & Jobs PayInternist/infectious Diseases Physician Salaries, Average Salary & Jobs Pay
From millions of real job salary data. 1 Internist/infectious Diseases Physician salary data. Average Internist/infectious Diseases Physician salary is $190,000 Detailed Internist/infectious Diseases Physician starting salary, median salary, pay scale, bonus data report
http://www.salarylist.com/jobs/Internist-Infectious-Diseases-Physician-Salary.htm
High- Versus Low-Dose Fluconazole Therapy for Empiric Treatment of Suspected Invasive Candidiasis Among High-Risk Patients in...High- Versus Low-Dose Fluconazole Therapy for Empiric Treatment of Suspected Invasive Candidiasis Among High-Risk Patients in...
By Chen, Hua Suda, Katie J; Turpin, Robin S; Pai, Manjunath P; Et al Key words: Candidiasis - Cost-effectiveness analysis - Fluconazole - Pharmacoeconomics ABSTRACT Background: High-dose fluconazole is an alternative for patients with candidemia caused by Candida glabrata or other Candida species with decreased fluconazole susceptibility. However, empiric high- dose fluconazole is not currently recommended and may result in higher drug costs and toxicity. Objective: To determine the cost-effectiveness of using empiric high-dose fluconazole in intensive care unit (ICU) with suspected invasive candidiasis. Design: Decision analytic model. Target population: ICU patients with suspected invasive candidiasis. Time horizon: Lifetime. Perspective: Societal. Interventions: Low-dose fluconazole (loading dose of 800 mg followed by 400 mg daily) vs. high-dose fluconazole (loading dose of 1600 mg followed by 800 mg daily). Generic fluconazole costs were used for the analysis. Outcome measures: Incremental ...
http://www.redorbit.com/news/health/962394/high_versus_lowdose_fluconazole_therapy_for_empiric_treatment_of_suspected/
Clinical experience of urine D-arabinitol/L-arabinitol ratio in the early diagnosis of invasive candidiasis in paediatric high...Clinical experience of urine D-arabinitol/L-arabinitol ratio in the early diagnosis of invasive candidiasis in paediatric high...
article{c7437ca5-8401-4db0-b1c9-267013d9baa1, abstract = {In 2 prospective studies, we previously reported on the early and accurate diagnosis of invasive candidiasis by determining the D-arabinitol/L-arabinitol (DA/LA) ratio in urine in neutropenic children with cancer at the paediatric oncology unit (POU) and in premature infants at the neonatal intensive care unit (NICU) at our hospital. In this retrospective study at the same units, we report how the DA/LA assay was implemented in clinical practice immediately after the prospective study periods. We found that, in the POU, the recommendation of regularly monitoring urine DA/LA ratios in patients at risk and considering antifungal therapy in the case of elevated ratios had been followed. A significant decrease in the incidence of culture positive invasive candidiasis may have been attributed to the introduction of the DA/LA assay. At the NICU, where the DA/LA assay was recommended only as an adjunct to other diagnostic tools, morbidity in ...
https://lup.lub.lu.se/search/publication/c7437ca5-8401-4db0-b1c9-267013d9baa1
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Candidemia and invasive candidiasis approach in critically ill patients: role of the echinocandins | accedaCRIS
Introduction. Invasive infections caused by Candida spp. in critically ill patients may significantly worsen their prognosis, so it is of great importance to establish an early detection and a suitable therapeutic strategy. The objective of this study was to define the differential role of echinocandins in treating certain critical patient profiles.Methodology. A scientific committee of 9 experts in infectious diseases, critical care, microbiology, and hospital pharmacy reviewed the existing evidence on the treatment of candidemia and invasive candidiasis in critically ill patients. After that, a questionnaire with 35 items was elaborated to be agreed by 26 specialists in the aforementioned disciplines using a modified Delphi method.Results. After two rounds of evaluation, a consensus was reached in terms of agreement in 66% of the items. Some of the consensuses achieved included: it is not necessary to adjust the dose of echinocandins during renal replacement therapy; the echinocandins are the ...
https://accedacris.ulpgc.es/handle/10553/73501
ECIL-6 guidelines for the treatment of invasive candidiasis, aspergillosis and mucormycosis in leukemia and hematopoietic stem...ECIL-6 guidelines for the treatment of invasive candidiasis, aspergillosis and mucormycosis in leukemia and hematopoietic stem...
The ECIL-5 meeting was held in September 2013 and involved 57 experts from 21 countries, including 3 non-European countries. Slides of the conclusions of the ECIL-5 were made available on the websites of the EORTC, EBMT, ELN, and ICHS. The ECIL-6 meeting was held in September 2015 with the presence of 55 experts from 24 countries, including 4 non-European countries (see list of collaborators at the end of this Review).. At both the ECIL-5 and the ECIL-6 meetings, the antifungal therapy working group made a search for new publications regarding treatment of invasive candidiasis, aspergillosis and mucormycosis. The group was divided into three subgroups, each being responsible for one of each fungal infection type. The literature search was performed in Pubmed and Cochrane databases. Abstracts presented at major congresses during the previous two years were also retrieved and integrated into the ECIL recommendation. All recommendations referring to an abstract, however, were classified as ...
http://www.haematologica.org/content/102/3/433
COVID-19: The Pandemic Through an Infectious Disease Physicians Eyes - AAPPR - Association for Advancing Physician and...COVID-19: The Pandemic Through an Infectious Disease Physicians Eyes - AAPPR - Association for Advancing Physician and...
As the COVID-19 pandemic spread over the world, taking over our collective global consciousness, I couldnt help but be reminded of the earliest days of my career as an infectious diseases physician. My fellowship began during another viral pandemic: H1N1 influenza. Every night brought calls to the bedsides of shockingly young patients who were profoundly sick in the ICU. The similarities between 2009 and the current COVID-19 pandemic, however, end there.. Despite being a new strain of influenza that was particularly deadly for young people, H1N1 quickly revealed its secrets to us. We learned early how it spread, how to treat it, and, eventually, how to develop a vaccine for it. The current novel coronavirus however, has offered no such early victories. Much of the spring passed in a blur as healthcare workers across the country struggled to cope with the sick flooding into our hospitals.. The pandemic made it impossible to deny the inequities in our society, with historically marginalized and ...
https://aappr.org/2020/11/17/covid-19-the-pandemic-through-an-infectious-disease-physicians-eyes/
Dr. Christopher Cirino, DO - Infectious Disease Physician in Portland, OR
Dr. Christopher Cirino, DO of Portland, OR patient reviews, appointments, phone number and quality report. Compare Dr. Cirino to other nearby Infectious Disease Physicians in Oregon.
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Dr. Jeffrey Lederman, MD - Infectious Disease Physician in New Rochelle, NY
Dr. Jeffrey Lederman, MD of New Rochelle, NY patient reviews, appointments, phone number and quality report. Compare Dr. Lederman to other nearby Infectious Disease Physicians in New York.
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MSG-10: a Phase 2 study of oral ibrexafungerp (SCY-078) following initial echinocandin therapy in non-neutropenic patients with...
TY - JOUR. T1 - MSG-10. T2 - a Phase 2 study of oral ibrexafungerp (SCY-078) following initial echinocandin therapy in non-neutropenic patients with invasive candidiasis. AU - Mycoses Study Group AU - Spec, Andrej. AU - Pullman, John. AU - Thompson, George Richard. AU - Powderly, William G.. AU - Tobin, Ellis H.. AU - Vazquez, Jose. AU - Wring, Stephen A.. AU - Angulo, David. AU - Helou, Silvia. AU - Pappas, Peter G.. PY - 2019/10/1. Y1 - 2019/10/1. N2 - OBJECTIVES: To evaluate the safety and efficacy of two dosing regimens of oral ibrexafungerp (formerly SCY-078), a novel orally bioavailable β-glucan synthase inhibitor, in subjects with invasive candidiasis versus the standard of care (SOC) and to identify the dose to achieve target exposure (15.4 μM·h) in ,80% of the intended population. METHODS: In a multinational, open-label study, patients with documented invasive candidiasis were randomized to receive step-down therapy to one of three treatment arms: two dosing regimens of novel oral ...
https://ucdavis.pure.elsevier.com/en/publications/msg-10-a-phase-2-study-of-oral-ibrexafungerp-scy-078-following-in
Acute Disseminated CandidiasisAcute Disseminated Candidiasis
Acute disseminated candidiasis, or invasive candidiasis, is a fungal infection of Candida spp. It usually presents as candidemia and progresses to several viscera (ie, liver, kidney, spleen, eyes, brain, and heart). Candida spp are among the most common causes of nosocomial bloodstream infections typically introduced from the gastrointestinal tract or from venous catheters.1 Clinical manifestations of candidiasis can be nonspecific but may include unresolved fever and may progress to sepsis. Definitive diagnosis requires histopathologic confirmation, but presumptive diagnosis is used frequently in high-risk immunosuppressed or neutropenic patients. Pharmacologic intervention is required with a confirmed positive culture, and catheter removal is recommended for suspected infections.2 The most common pathogen for invasive candidiasis is C albicans (41%-65%); however, non-albicans Candida spp resistant to conventional treatments have emerged as prevalent causes of candidiasis, including C ...
http://www.pharmacytimes.com/publications/issue/2006/2006-03/2006-03-5329
Pharmacokinetics of Anidulafungin in critically ill patients in the Intensive Care Unit with suspected or proven invasive...Pharmacokinetics of Anidulafungin in critically ill patients in the Intensive Care Unit with suspected or proven invasive...
Echinocandins, such as anidulafungin are first line treatment for candidemia or invasive candidiasis in critically ill patients. There is conflicting data on the pharmacokinetic properties of anidulafungin in ICU patients. Adult ICU patients (from 3 hospitals) receiving anidulafungin for suspected or proven fungal infections were included. Patient were considered evaluable ... read more when a pharmacokinetic curve on day 3 could be completed. 23 out of 36 patients (7 female, 16 male) were evaluable. Median (range) age and bodyweight were 66 (28-88) yr and 76 (50-115) kg. Pharmacokinetic sampling on day 3 (n=23) resulted in a median anidulafungin AUC0-24h of 72.1 (IQR 61.3-94.0) mg*h*L(-1), a median C24 of 2.2 (IQR 1.9-2.9) mg/L, a median Cmax of 5.3 (IQR 4.1-6.0) mg/L, a median Vd of 46.0 (IQR 32.2-60.2) L and a median CL of 1.4 (IQR 1.1-1.6) L*h-1. Pharmacokinetic sampling on day 7 (n=13) resulted in a median AUC0-24h of 82.7 (IQR 73.0 - 129.5) mg*h*L(-1), a median Cmin of 2.8 (IQR 2.2 - 4.2) ...
https://dspace.library.uu.nl/handle/1874/355409
Lokaverkefni: Candidemia and invasive candidiasis: pathogenesis, molecular epidemiology, and predictors of outcome. A...Lokaverkefni: Candidemia and invasive candidiasis: pathogenesis, molecular epidemiology, and predictors of outcome. A...
The annual incidence of candidemia in Iceland increased from 1.4 cases/100,000 inhabitants/year during 1980-1984 to 5.3 cases/100,000 inhabitants/year during 2000-2006 (p,0.001), with the greatest increase in incidence occurring among infants ,1 year of age and the elderly (age, ,60 years). C. albicans was the predominant species responsible (61.6%). The national import of fluconazole increased approximately 5.5-fold from 1991 through 2006, but increased resistance to this agent was not observed. Most cases occurred in intensive care units (35.8%) and surgical wards (30.1%). In multivariate analysis, prompt removal of central venous catheters (odds ratio [OR], for death, 0.22) and septic shock (OR for death, 8.01) were the strongest independent predictors of outcome. PCR fingerprinting of Candida BSIs (n=219) from 94.4% of cases during 1991-2006 revealed temporo-spatial associations between 18.7-39.9% of all infections, suggestive of nosocomial clustering. When the virulence of C. albicans and ...
https://skemman.is/handle/1946/7859
Rapid Species Diagnosis for Invasive Candidiasis Using Mass SpectrometryRapid Species Diagnosis for Invasive Candidiasis Using Mass Spectrometry
Background Matrix-assisted laser desorption ionisation time of flight mass spectrometry (MALDI TOF-MS) allows the identification of most bacteria and an increasing number of fungi. The potential for the highest clinical benefit of such methods would be in severe acute infections that require prompt treatment adapted to the infecting species. Our objective was to determine whether yeasts could be identified directly from a positive blood culture, avoiding the 1-3 days subculture step currently required before any therapeutic adjustments can be made. Methodology/Principal Findings Using human blood spiked with Candida albicans to simulate blood cultures, we optimized protocols to obtain MALDI TOF-MS fingerprints where signals from blood proteins are reduced. Simulated cultures elaborated using a set of 12 strains belonging to 6 different species were then tested. Quantifiable spectral differences in the 5000-7400 Da mass range allowed to discriminate between these species and to build a reference
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0008862
December 2017 Briefing - Infectious Disease | Physicians Weekly for Medical News, Journals & ArticlesDecember 2017 Briefing - Infectious Disease | Physicians Weekly for Medical News, Journals & Articles
Full Text (subscription or payment may be required). Flu Vaccine Expected to Protect Against Most U.S. H3N2 Viruses. FRIDAY, Dec. 15, 2017 (HealthDay News) - A novel bioinformatics approach can predict vaccine effectiveness for the influenza season, and indicates that the current vaccines are likely to be effective against H3N2 flu viruses in the U.S. 2017/2018 flu season, according to research published online Nov. 29 in F1000 Research.. Abstract/Full Text. Functional Limitations Ongoing With Congenital Zika. FRIDAY, Dec. 15, 2017 (HealthDay News) - Severe functional limitations are reported among children with microcephaly and laboratory evidence of Zika virus infection in infancy, according to research published in the Dec. 15 issue of the U.S. Centers for Disease Control and Preventions Morbidity and Mortality Weekly Report.. Abstract/Full Text. Making Insurers Participate in Marketplace Could Cut Volatility. THURSDAY, Dec. 14, 2017 (HealthDay News) - Requiring insurers that participate in ...
https://www.physiciansweekly.com/december-2017-briefing-infectious-disease/
Infectious disease physician chats on swine flu - schurz-petoskeynews
Swine flu expert chats liveShould I eat pork? Should I avoid public places? Is this scratchy throat a sign of the swine flu?These and other questions related to contracting, avoiding and pinpointing
http://articles.petoskeynews.com/2009-05-08/swine-flu_24018710
1 Antiviral Drug Products Advisory Committee Meeting NDA voriconazole tablets NDA voriconazole for injection Rosemary Tiernan,...1 Antiviral Drug Products Advisory Committee Meeting NDA voriconazole tablets NDA voriconazole for injection Rosemary Tiernan,...
3 Indications Requested in the NDA Treatment of invasive aspergillosis Empiric antifungal therapy of febrile neutropenic patients Treatment of: -candida esophagitis -serious candida infections -serious fungal infections due to Fusarium and Scedosporium spp. -serious fungal infections in patients refractory or intolerant to other therapy
http://slideplayer.com/slide/1401410/
Dr. Marc Shalek, MD | Plano, TX | Cardiovascular Disease PhysicianDr. Marc Shalek, MD | Plano, TX | Cardiovascular Disease Physician
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Dr. Kristine Batten, MD, FACC | Oakland, CA | Cardiovascular Disease PhysicianDr. Kristine Batten, MD, FACC | Oakland, CA | Cardiovascular Disease Physician
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Impact of Antimicrobial Prophylaxis for Severe Acute Pancreatitis on the Development of Invasive Candidiasis: A Large...Impact of Antimicrobial Prophylaxis for Severe Acute Pancreatitis on the Development of Invasive Candidiasis: A Large...
TY - JOUR. T1 - Impact of Antimicrobial Prophylaxis for Severe Acute Pancreatitis on the Development of Invasive Candidiasis. T2 - A Large Retrospective Multicenter Cohort Study. AU - Horibe, Masayasu. AU - Sanui, Masamitsu. AU - Sasaki, Mitsuhito. AU - Honda, Hitoshi. AU - Ogura, Yuki. AU - Namiki, Shin. AU - Sawano, Hirotaka. AU - Goto, Takashi. AU - Ikeura, Tsukasa. AU - Takeda, Tsuyoshi. AU - Oda, Takuya. AU - Yasuda, Hideto. AU - Miyazaki, Dai. AU - Hirose, Kaoru. AU - Kitamura, Katsuya. AU - Chiba, Nobutaka. AU - Ozaki, Tetsu. AU - Yamashita, Takahiro. AU - Koinuma, Toshitaka. AU - Oshima, Taku. AU - Yamamoto, Tomonori. AU - Hirota, Morihisa. AU - Yamamoto, Satoshi. AU - Oe, Kyoji. AU - Ito, Tetsuya. AU - Masuda, Yukiko. AU - Saito, Nobuyuki. AU - Iwasaki, Eisuke. AU - Kanai, Takanori. AU - Mayumi, Toshihiko. N1 - Publisher Copyright: © 2019 Wolters Kluwer Health, Inc. All rights reserved. Copyright: Copyright 2019 Elsevier B.V., All rights reserved.. PY - 2019/4/1. Y1 - 2019/4/1. N2 - ...
https://pure.fujita-hu.ac.jp/en/publications/impact-of-antimicrobial-prophylaxis-for-severe-acute-pancreatitis
Feds Infectious Diseases Strategy Must be Broader than Biodefense, Infectious Disease Physicians Say | Infection Control TodayFeds Infectious Diseases Strategy Must be Broader than Biodefense, Infectious Disease Physicians Say | Infection Control Today
The House Energy and Commerce Committees Subcommittee on Health is considering reauthorization of the Project BioShield Act, legislation passed in 2004 that is designed to spur companies into making countermeasures against a bioterrorist attack. However, in testimony before the subcommittee today, Martin J. Blaser, MD, president of the Infectious Diseases Society of America (IDSA), emphasized a different threat, one that infectious diseases physicians witness every day: the burden of antimicrobial-resistant infections such as methicillin-resistant Staphylococcus aureus (MRSA). Antimicrobial resistant infections have created a silent epidemic in communities and hospitals across the country, Blaser said, crippling and killing a growing number of otherwise-healthy people and driving up healthcare costs. To make matters worse, the IDSA says, the pharmaceutical industry has lost interest in developing new antibiotics to fight these infections because they are not as profitable as drugs for ...
https://www.infectioncontroltoday.com/epidemiology-surveillance/feds-infectious-diseases-strategy-must-be-broader-biodefense-infectious
Reply to Van Daele et al., Fluconazole Underexposure in Critically Ill Patients: a Matter of Using the Right Targets?<...Reply to Van Daele et al., Fluconazole Underexposure in Critically Ill Patients: a Matter of Using the Right Targets?<...
TY - JOUR. T1 - Reply to Van Daele et al., Fluconazole Underexposure in Critically Ill Patients. T2 - a Matter of Using the Right Targets?. AU - Märtson, A G. AU - Boonstra, J M. AU - Sandaradura, I. AU - Kosterink, J G. AU - van der Werf, T S. AU - Marriott, D J E. AU - Zijlstra, J G. AU - Touw, D J. AU - Alffenaar, J W C. N1 - Copyright © 2021 American Society for Microbiology.. PY - 2021/5. Y1 - 2021/5. N2 - We thank Van Daele et al (1) for their interest in our study investigating the pharmacokinetics in critically ill patients with aim to optimize fluconazole dosing for the prevention and treatment of invasive candida infections (2).….. AB - We thank Van Daele et al (1) for their interest in our study investigating the pharmacokinetics in critically ill patients with aim to optimize fluconazole dosing for the prevention and treatment of invasive candida infections (2).….. UR - http://www.scopus.com/inward/record.url?scp=85106667811&partnerID=8YFLogxK. U2 - ...
https://research.rug.nl/nl/publications/reply-to-van-daele-et-al-fluconazole-underexposure-in-critically-
Bench-to-bedside review: Candida infections in the intensive care unit | Critical Care | Full TextBench-to-bedside review: Candida infections in the intensive care unit | Critical Care | Full Text
Invasive mycoses are life-threatening opportunistic infections and have emerged as a major cause of morbidity and mortality in critically ill patients. This review focuses on recent advances in our understanding of the epidemiology, diagnosis and management of invasive candidiasis, which is the predominant fungal infection in the intensive care unit setting. Candida spp. are the fourth most common cause of bloodstream infections in the USA, but they are a much less common cause of bloodstream infections in Europe. About one-third of episodes of candidaemia occur in the intensive care unit. Until recently, Candida albicans was by far the predominant species, causing up to two-thirds of all cases of invasive candidiasis. However, a shift toward non-albicans Candida spp., such as C. glabrata and C. krusei, with reduced susceptibility to commonly used antifungal agents, was recently observed. Unfortunately, risk factors and clinical manifestations of candidiasis are not specific, and conventional culture
https://ccforum.biomedcentral.com/articles/10.1186/cc6212
Real-life diagnostic performance of T2Candida among ICU patients with risk factors for invasive candidiasis - T2 BiosystemsReal-life diagnostic performance of T2Candida among ICU patients with risk factors for invasive candidiasis - T2 Biosystems
The T2Dx Instrument, the T2Bacteria and T2Candida Panels have received marketing authorization from the U.S. Food and Drug Administration. All other T2 Biosystems products are considered investigational and for research use only.. T2 Biosystems®, T2MR®, T2Bacteria®, T2Candida®, and T2Dx® are registered trademarks of T2 Biosystems, Inc. T2Biosystems and the T2 Biosystems, Inc. logo design are registered trademarks or trademarks of T2Biosystems, Inc. All software and documentation is subject to T2 Biosystems, Inc. copyrights. All rights reserved. T2Direct Diagnostics™, T2HemoStat™, and T2Plex™ are trademarks of T2 Biosystems, Inc.. © 2019 T2 Biosystems, Inc. ...
https://www.t2biosystems.com/publications/real-life-diagnostic-performance-of-t2candida-among-icu-patients-with-risk-factors-for-invasive-candidiasis/
Medicines to treat delirium in critically ill adult patients | CochraneMedicines to treat delirium in critically ill adult patients | Cochrane
Review question. We reviewed the evidence from randomized controlled trials for the benefits and safety of all prescription medicines used to treat critically ill adult patients with delirium in the intensive care units (ICUs) of hospitals.. Background Delirium is commonly associated with surgery, infection, or critical illness. It is experienced as new-onset, generally short-term inability to think clearly. Patients with delirium shift between periods of clear thinking and periods of agitation and/or great sleepiness and confusion. Lack of sleep, pain, a noisy environment, physical restraint, and the use of sedatives and strong analgesics are some of the contributing factors. Delirium affects both immediate and longer-term health outcomes of critically ill patients as it can increase the length of time a breathing machine is required, time spent in the ICU and in hospital, and the chance of functional weakening and death. The odds of a poor outcome with delirium are increased with frail ...
https://www.cochrane.org/CD011749/EMERG_medicines-treat-delirium-critically-ill-adult-patients
Diagnostic value of procalcitonin and presepsin for sepsis in critically ill adult patients: A systematic review and meta...Diagnostic value of procalcitonin and presepsin for sepsis in critically ill adult patients: A systematic review and meta...
TY - JOUR. T1 - Diagnostic value of procalcitonin and presepsin for sepsis in critically ill adult patients. T2 - A systematic review and meta-analysis. AU - Kondo, Yutaka. AU - Umemura, Yutaka. AU - Hayashida, Kei. AU - Hara, Yoshitaka. AU - Aihara, Morio. AU - Yamakawa, Kazuma. PY - 2019/4/15. Y1 - 2019/4/15. N2 - Background: Early and accurate diagnosis of sepsis is challenging. Although procalcitonin and presepsin have been identified as potential biomarkers to differentiate between sepsis and other non-infectious causes of systemic inflammation, the diagnostic accuracy of these biomarkers remains controversial. Herein, we performed a comprehensive meta-analysis to assess the overall diagnostic value of procalcitonin and presepsin for the diagnosis of sepsis. Methods: We searched three electronic databases (MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials) for relevant studies. Two authors independently screened articles on the basis of inclusion and exclusion ...
https://pure.fujita-hu.ac.jp/ja/publications/diagnostic-value-of-procalcitonin-and-presepsin-for-sepsis-in-cri
Association between vitamin D deficiency and mortality in critically ill adult patients: a meta-analysis of cohort studies
Association between vitamin D deficiency and mortality in critically ill adult patients: a meta-analysis of cohort studies - up-to-the-minute news and headlines. 7thSpace is a online portal covering topics such as Family, Business, Entertainment, Headlines, Recipes and more. A place for the whole family featuring many different sections to chose from.
http://7thspace.com/headlines/500781/association_between_vitamin_d_deficiency_and_mortality_in_critically_ill_adult_patients_a_meta_analysis_of_cohort_studies.html
Candidaemia and cancer: patients are not all the same.Candidaemia and cancer: patients are not all the same.
BACKGROUND: Most of the studies about invasive Candida infections in cancer patients have focused on haematological patients. The aim of this study was to provide information about risk factors for candidaemia in patients with solid tumours. METHODS: Retrospective cohort study. During a 9-year period (1995-2003) we reviewed all cases of candidaemia that affected cancer patients in Santa Casa Complexo Hospitalar, Brazil. RESULTS: During the period of study, 210 patients had the diagnosis of candidaemia in our medical centre, and 83 of these patients had cancer (39.5%). The majority of patients with cancer had solid tumours (77.1%), mostly in the alimentary tract. Most of solid cancers were non-metastatic (71.9%). Major diagnoses in patients with haematological neoplasia were acute leukaemia (n = 13), high grade non-Hodgkin lymphoma (n = 5) and Hodgkins disease (n = 1). Non-Candida albicans species caused 57.8% of the episodes of candidaemia in patients with cancer, mainly in patients with ...
https://christie.openrepository.com/handle/10541/72753
Antifungals patterns in critical patients with candidiasis in the intensive care units at Sanglah General Hospital 2019 |...Antifungals patterns in critical patients with candidiasis in the intensive care units at Sanglah General Hospital 2019 |...
Abstract Introduction: The prompt initiation of appropriate antifungal therapy is essential in controlling invasive candidiasis and improving the prognosis in critical patients undergoing treatment in the Intensive Care Unit. Candida Score can assess patients at risk of candidiasis and is expected to assist clinicians in starting antifungal therapy in patients suspected Candidiasis. The purpose of this study was to determine the pattern of antifungal administration in critically ill patients with candidiasis in the Intensive Care Unit at Sanglah General Hospital. Patients and Methods: The design of this study is a cross-sectional descriptive study involving critically ill patients who were under treatment in Intensive Care Unit of Sanglah General Hospital from Januari to June 2019. The patients included in this study were patients who were ≥ 18 years old and under treatment in ICU for at least 7 days. Results: There are 64 patients undergoing treatment in the Intensive Care Unit. From 64 patients,
https://nsmc.indoscholar.com/index.php/nsmc/article/view/83
Infectious Diseases Physicians and Public Health Experts Call FDA s New Approach for Antimicrobial Use in Animals a Major Win...Infectious Diseases Physicians and Public Health Experts Call FDA s New Approach for Antimicrobial Use in Animals a Major Win...
Washington, DC - Trust for Americas Health (TFAH) and The Infectious Diseases Society of America (IDSA) applaud the Obama administration and the Food and Drug Administration (FDA) for adopting a new approach for the use of antimicrobial drugs in animal agriculture. These actions demonstrate a clear commitment to sound and science-based policies that will protect the health of every American.. In a letter to Melody Barnes, President Obamas assistant for domestic policy, IDSA and TFAH expressed their strong support for the administrations new public health approach to antimicrobial use in animals, which calls for phasing out the use of antimicrobial drugs for growth promotion and feed efficiency. The new approach also requires that all other uses of these drugs be carried out under the supervision of a veterinarian and within the boundaries of a valid veterinarian-client-patient relationship-thereby ending over-the-counter sales of tons of antimicrobial drugs annually.. We recognize that ...
http://healthyamericans.org/newsroom/releases/?releaseid=185
Isavuconazole vs. Caspofungin for Candidemia | 2019-07-19 | Relias Media - Continuing Medical Education PublishingIsavuconazole vs. Caspofungin for Candidemia | 2019-07-19 | Relias Media - Continuing Medical Education Publishing
By Richard R. Watkins, MD, MS, FACP, FIDSA Professor of Internal Medicine, Northeast Ohio Medical University; Division of Infectious Diseases, Cleveland Clinic Akron General, Akron, OH Dr. Watkins reports no financial relationships relevant to this field of study. SYNOPSIS: In a large, randomized, double-blind, multicenter clinical trial, researchers found that isavuconazole did not meet the primary endpoint of noninferiority compared to caspofungin for candidemia and invasive candidiasis. SOURCE: Kullberg BJ, Viscoli C, Pappas PG, et al. Isavuconazole versus caspofungin in the treatment of candidemia and . . .
https://www.reliasmedia.com/articles/144799-isavuconazole-vs-caspofungin-for-candidemia
anidulafungin QuickView - Correlation Engine
Anidulafungin is a semi-synthetic lipopeptide synthesized from a fermentation product of Aspergillus nidulans. Anidulafungin is an echinocandin, a class of antifungal drugs that inhibits the synthesis of 1,3-β-D-glucan, an essential component of fungal cell walls. Anidulafungin is active in vitro against many Candida, as well as some Aspergillus. Like other echinocandins, anidulafungin is not active against Cryptococcus neoformans, Trichosporon, Fusarium, or zygomycetes ...
http://www.nextbio.com/b/search/details/anidulafungin?id=474903&type=compound
Invasive candidiasisInvasive candidiasis
... is an infection (candidiasis) that can be caused by various species of Candida yeast. Unlike Candida ... Review). Candidiasis (Invasive) in the MSD (Merck) Manual Clinical Practice Guideline for the Management of Candidiasis: 2016 ... "Invasive Candidiasis , Candidiasis , Types of Fungal Diseases , Fungal Diseases , CDC". www.cdc.gov. Retrieved 2017-04-02. " ... "Symptoms , Invasive Candidiasis , Candidiasis , Types of Diseases , Fungal Diseases , CDC". www.cdc.gov. Retrieved 2017-04-03. ...
https://en.wikipedia.org/wiki/Invasive_candidiasis
CandidiasisCandidiasis
... caused by Candida Systemic candidiasis Candidemia, a form of fungemia which may lead to sepsis Invasive candidiasis ( ... Mucosal candidiasis Oral candidiasis (thrush, oropharyngeal candidiasis) Pseudomembranous candidiasis Erythematous candidiasis ... Vaginal candidiasis can cause congenital candidiasis in newborns. In oral candidiasis, simply inspecting the person's mouth for ... "Symptoms of Invasive Candidiasis". cdc.gov. February 13, 2014. Archived from the original on 29 December 2014. Retrieved 28 ...
https://en.wikipedia.org/wiki/Candidiasis
Beta-glucanBeta-glucan
Kullberg, Bart Jan; Arendrup, Maiken C. (8 October 2015). "Invasive Candidiasis". The New England Journal of Medicine. 373 (15 ... An assay to detect the presence of (1,3)-β-D-glucan in blood is marketed as a means of identifying invasive or disseminated ... 1995). "Plasma (13)-beta-D-glucan measurement in diagnosis of invasive deep mycosis and fungal febrile episodes". Lancet. 345 ( ... 2004). "Beta-D-glucan as a diagnostic adjunct for invasive fungal infections: validation, cutoff development, and performance ...
https://en.wikipedia.org/wiki/Beta-glucan
FungemiaFungemia
Bacteremia Candidiasis Fungicide Mycosis "Statistics". Invasive Candidiasis. United States: Centers for Disease Control and ... The gold standard for the diagnosis of invasive candidiasis and candidemia is a positive culture. Blood cultures should be ... Clancy, Cornelius J.; Nguyen, M. Hong (1 May 2013). "Finding the "Missing 50%" of Invasive Candidiasis: How Nonculture ... The most common type, also known as candidemia, candedemia, or systemic candidiasis, is caused by Candida species; candidemia ...
https://en.wikipedia.org/wiki/Fungemia
DefensinDefensin
"Candidiasis". Cellceutix. Archived from the original on 2015-02-07. Retrieved 2015-03-02. Diamond G, Scott R. "A Novel ... Therapeutic For Invasive Candiasis". Grantome. Fox Chase Chemical Diversity Center. Ryan LK, Freeman KB, Masso-Silva JA, ... July 2014). "Activity of potent and selective host defense peptide mimetics in mouse models of oral candidiasis". Antimicrobial ... especially for candidiasis. Host defense peptides, to which defensins belong Hazlett L, Wu M (January 2011). "Defensins in ...
https://en.wikipedia.org/wiki/Defensin
Candida albicansCandida albicans
By one estimate, invasive candidiasis contracted in a hospital causes 2,800 to 11,200 deaths yearly in the US. Nevertheless, ... Singh R, Chakrabarti A (2017). "Invasive Candidiasis in the Southeast-Asian Region". In Prasad R (ed.). Candida albicans: ... ISBN 978-3-319-50408-7. Pfaller MA, Diekema DJ (January 2007). "Epidemiology of invasive candidiasis: a persistent public ... Yapar N (2016-04-16). "Epidemiology and risk factors for invasive candidiasis". Therapeutics and Clinical Risk Management. 10: ...
https://en.wikipedia.org/wiki/Candida_albicans
Association of Medical Microbiology and Infectious Disease CanadaAssociation of Medical Microbiology and Infectious Disease Canada
"Canadian clinical practice guidelines for invasive candidiasis in adults". The Canadian Journal of Infectious Diseases & ...
https://en.wikipedia.org/wiki/Association_of_Medical_Microbiology_and_Infectious_Disease_Canada
AnidulafunginAnidulafungin
Candidemia and other forms of invasive Candida infections (intra-abdominal abscess and peritonitis) Esophageal candidiasis ... Vicuron Pharmaceuticals Files New Drug Application (NDA) for Anidulafungin for Treatment of Invasive Candidiasis/Candidemia ... dose-ranging study evaluating the safety and efficacy of anidulafungin in invasive candidiasis and candidemia". Antimicrob ... "Effectiveness of anidulafungin in eradicating Candida species in invasive candidiasis". Antimicrob Agents Chemother. 49 (11): ...
https://en.wikipedia.org/wiki/Anidulafungin
SepsisSepsis
Delaloye J, Calandra T (January 2014). "Invasive candidiasis as a cause of sepsis in the critically ill patient". Virulence. 5 ... and also the increase in the number of invasive procedures being performed, has led to an increased rate of sepsis. The term " ... before a planned surgery or an invasive procedure. IV immunoglobulin is not recommended because its beneficial effects are ...
https://en.wikipedia.org/wiki/Sepsis
Oral candidiasisOral candidiasis
Rarely, a superficial candidal infection such as oral candidiasis can cause invasive candidiasis, and even prove fatal. The ... Unlike other forms of candidiasis, hyperplastic candidiasis may show dysplasia. Oral candidiasis can be treated with topical ... "plaque-like candidiasis" or "nodular candidiasis". The most common appearance of hyperplastic candidiasis is a persistent white ... a secondary oral candidiasis). These include Localized chronic mucocutaneous candidiasis, diffuse mucocutaneous candidiasis ( ...
https://en.wikipedia.org/wiki/Oral_candidiasis
Candida tropicalisCandida tropicalis
Usage of caspofungin will efficiently target against oropharyngeal and oesophgeal candidiasis and invasive candidiasis. ... invasive and disseminated candidiasis, gastrointestinal candidiasis and candidemia. C. tropicalis colonization is favoured in ... If an infection involves interdigital candidiasis, paronychia and diaper rash, subject is likely to have cutaneous candidiasis ... a common risk factor for individuals that are susceptible for invasive candidiasis development. Candidemia is a worldwide ...
https://en.wikipedia.org/wiki/Candida_tropicalis
MicafunginMicafungin
October 2007). "Micafungin versus caspofungin for treatment of candidemia and other forms of invasive candidiasis". Clinical ... Pettengell K, Mynhardt J, Kluyts T, Lau W, Facklam D, Buell D (August 2004). "Successful treatment of oesophageal candidiasis ... Micafungin, sold under the brand name Mycamine, is an echinochandin antifungal medication used to treat and prevent invasive ... Micafungin is indicated for the treatment of candidemia, acute disseminated candidiasis, Candida peritonitis, abscesses and ...
https://en.wikipedia.org/wiki/Micafungin
Debaryomyces hanseniiDebaryomyces hansenii
Also known as Candida famata, it accounts for up to 2% of invasive candidiasis cases. Debaryomyces hansenii is an osmo-, halo- ...
https://en.wikipedia.org/wiki/Debaryomyces_hansenii
Candida aurisCandida auris
Candidiasis is most often acquired in hospitals by patients with weakened immune systems. It can cause invasive candidiasis, in ... Often, candidiasis is acquired in hospitals by patients with weakened immune systems. C. auris can cause invasive candidiasis ( ... It is one of the few species of the genus Candida which cause candidiasis in humans. ... Candida auris is one of the few Candida species that can cause candidiasis in humans. ...
https://en.wikipedia.org/wiki/Candida_auris
Fungal infectionFungal infection
700,000 cases of invasive candidiasis, 500,000 cases of pneumocystosis of lungs, 250,000 cases of invasive aspergillosis, and ... and is able to cause both mild candidiasis in healthy people and severe invasive candidiasis in those who cannot fight ... The most common serious fungal infections in people with COVID-19 include aspergillosis and invasive candidiasis. COVID-19- ... Some tinea and candidiasis infections of the skin can appear similar to eczema and lichen planus. Pityriasis versicolor can ...
https://en.wikipedia.org/wiki/Fungal_infection
White-crowned parrotWhite-crowned parrot
It is invasive and predominately occurs in internal organs. The average age of occurrence is 10 years with a range of 3 to 30 ... Hand fed pionus are more susceptible to Candidiasis due to unsanitary feeding equipment. Chlamydophila is also common in pionus ... It is locally invasive and multicentric. Surgical removal is not curative as the majority of tumors will regrow within days to ...
https://en.wikipedia.org/wiki/White-crowned_parrot
PosaconazolePosaconazole
... is used to treat invasive Aspergillus and Candida infections. It is also used for the treatment of oropharyngeal ... candidiasis (OPC), including OPC refractory to itraconazole and/or fluconazole therapy. It is also used to treat invasive ... Clinical evidence for its utility in treatment of invasive disease caused by Fusarium species (fusariosis) is limited. It ... January 2007). "Treatment of invasive aspergillosis with posaconazole in patients who are refractory to or intolerant of ...
https://en.wikipedia.org/wiki/Posaconazole
Candida hypersensitivityCandida hypersensitivity
Several Candida species can also cause a serious infection known as invasive candidiasis, which can be systemic if blood borne ... After reading publications by C. Orian Truss, M.D., Crook proposed the idea that a condition he termed systemic candidiasis, or ... "Candidiasis Hypersensitivity". National Council Against Health Fraud. Retrieved 18 January 2014. (Articles with alternative ... The American Academy of Allergy, Asthma, and Immunology strongly criticized the concept of "candidiasis hypersensitivity ...
https://en.wikipedia.org/wiki/Candida_hypersensitivity
ErythrasmaErythrasma
These are both non-invasive routes. Erythrasma is often mistakenly diagnosed as dermatophytic infection which is a fungal ... The differential diagnosis for erythrasma includes psoriasis, candidiasis, dermatophytosis, and intertrigo. The diagnosis can ...
https://en.wikipedia.org/wiki/Erythrasma
NystatinNystatin
... invasive infection, and death. It is effective in treating oral candidiasis in elderly people who wear dentures. It is also ... It may also be used to prevent candidiasis in those who are at high risk. Nystatin may be used by mouth, in the vagina, or ... It has been found to reduce the rate of invasive fungal infections and also reduce deaths when used in these babies. Liposomal ... Lyu, Xin; Zhao, Chen; Yan, Zhi-Min; Hua, Hong (2016). "Efficacy of nystatin for the treatment of oral candidiasis: a systematic ...
https://en.wikipedia.org/wiki/Nystatin
EchinocandinEchinocandin
... showed weekly treatment with Rezafungin was safe and efficacious in the treatment of candidemia and/or invasive candidiasis. ... Caspofungin is used in the treatment of febrile neutropenia and as "salvage" therapy for the treatment of invasive ... Rezafungin versus Caspofungin in a Phase 2, Randomized, Double-Blind Study for the Treatment of Candidemia and Invasive ... Chandrasekar, P H (24 January 2007). "Increased dose of echinocandins for invasive fungal infections: bonanza for the patient ...
https://en.wikipedia.org/wiki/Echinocandin
1994 expanded World Health Organization AIDS case definition1994 expanded World Health Organization AIDS case definition
... candidiasis of the oesophagus (which may be presumptively diagnosed based on the presence of oral candidiasis accompanied by ... clinically diagnosed life-threatening or recurrent episodes of pneumonia, with or without etiological confirmation invasive ...
https://en.wikipedia.org/wiki/1994_expanded_World_Health_Organization_AIDS_case_definition
HIV and pregnancyHIV and pregnancy
If these tests are abnormal or an abnormal ultrasound is performed, invasive testing via amniocentesis or chorionic villus ... These children can also develop opportunistic infections, notably including recurrent oral thrush (Candidiasis) and/or Candida ... diaper rash, pneumonia, or invasive bacterial, viral, parasitic, or fungal infections. Neurologic symptoms, particularly HIV ...
https://en.wikipedia.org/wiki/HIV_and_pregnancy
Candida (fungus)Candida (fungus)
... vaginal candidiasis) and subpreputial candidiasis, which may cause balanitis, to systemic, such as fungemia and invasive ... Systemic infections of the bloodstream and major organs (candidemia or invasive candidiasis), particularly in patients with an ... such as oropharyngeal candidiasis (thrush) or vulvovaginal candidiasis ( ... Oral candidiasis is common in elderly denture-wearers. In otherwise healthy individuals, these superficial infections can be ...
https://en.wikipedia.org/wiki/Candida_(fungus)
Carol KumamotoCarol Kumamoto
... when the host organism becomes immunocompromised the pathogen produces invasive lesions that are associated with candidiasis. ... Candidiasis is complicated to diagnose and can be fatal. Kumamoto demonstrated that low levels of the protein Efg1p permit fast ... She is also interested in how C. albicans interacts with its host during colonisation and invasive diseases. She is a Fellow of ... She is interested in the mechanism by which C. albicans interacts with its host during colonisation and invasive degrees. For ...
https://en.wikipedia.org/wiki/Carol_Kumamoto
VoriconazoleVoriconazole
... is used to treat invasive aspergillosis and candidiasis and fungal infections caused by Scedosporium and Fusarium ... This includes aspergillosis, candidiasis, coccidioidomycosis, histoplasmosis, penicilliosis, and infections by Scedosporium or ... August 2002). "Voriconazole versus amphotericin B for primary therapy of invasive aspergillosis". The New England Journal of ...
https://en.wikipedia.org/wiki/Voriconazole
Antimicrobial stewardshipAntimicrobial stewardship
... and invasive candidiasis guard the patient's microbiome, including the gut flora, respiratory tract flora, urogenital tract ...
https://en.wikipedia.org/wiki/Antimicrobial_stewardship
CDC classification system for HIV infectionCDC classification system for HIV infection
Candidiasis of bronchi, trachea, or lungs Candidiasis esophageal Cervical cancer (invasive) Coccidioidomycosis, disseminated or ... In 1993, the CDC added pulmonary tuberculosis, recurrent pneumonia, and invasive cervical cancer to the list of clinical ...
https://en.wikipedia.org/wiki/CDC_classification_system_for_HIV_infection
Ground-glass opacityGround-glass opacity
Invasive aspergillosis Candidiasis Mucormycosis Pulmonary cryptococcus Paracoccidioidomycosis Pulmonary Schistosomiasis ... 15 mm almost always represent an invasive adenocarcinoma. Centrilobular GGOs refer to opacities occurring within one or ...
https://en.wikipedia.org/wiki/Ground-glass_opacity
Fungal pneumoniaFungal pneumonia
... resulting in invasive pulmonary aspergillosis rarely, candidiasis has pulmonary manifestations in immunocompromised patients. ... Pneumonia Meersseman W, Lagrou K, Maertens J, Van Wijngaerden E (July 2007). "Invasive aspergillosis in the intensive care unit ... Bulpa P, Dive A, Sibille Y (October 2007). "Invasive pulmonary aspergillosis in patients with chronic obstructive pulmonary ...
https://en.wikipedia.org/wiki/Fungal_pneumonia
Pathogenic fungusPathogenic fungus
In the case of mucosal candidiasis, the cells that produce cytokine IL-17 are extremely important in maintaining innate ... It can cause potentially lethal invasive infection in immunocompromised individuals. A. fumigatus has a fully functional sexual ... ISBN 978-1-904455-32-5. Martins N, Ferreira IC, Barros L, Silva S, Henriques M (2014). "Candidiasis: predisposing factors, ...
https://en.wikipedia.org/wiki/Pathogenic_fungus
XerostomiaXerostomia
Oral candidiasis - A loss of the antimicrobial actions of saliva may also lead to opportunistic infection with Candida species ... Banerjee, Avijit; Watson, Timothy F. (2015). Pickard's Guide to Minimally Invasive Operative Dentistry. Oxford University Press ...
https://en.wikipedia.org/wiki/Xerostomia
AIDS-defining clinical conditionAIDS-defining clinical condition
Are the following:[citation needed] Candidiasis of bronchi, trachea, or lungs Candidiasis esophageal Coccidioidomycosis, ... recurrent pneumonia and invasive cervical cancer to the list of clinical conditions in the AIDS surveillance case definition ... invasive) Mycobacterium tuberculosis, any site (pulmonary) Pneumonia (recurrent) Additional conditions are included for ...
https://en.wikipedia.org/wiki/AIDS-defining_clinical_condition
Oral manifestations of systemic diseaseOral manifestations of systemic disease
Saliva sampling may be a non-invasive way to detect changes in the gut microbiome and changes in systemic disease. Another ... It can also present in the mouth as angular chelitis, which is an infection caused by either staphylococcus or candidiasis, and ... particularly oral candidiasis and oral hairy leukoplakia. Nascimento, Marcelle; Goodson, J. Max; Hartman, Mor-Li; Shi, Ping; ... candidiasis, ulceration and gingivitis/periodontitis (Godara et al., 2011). There are a number of oral complications following ...
https://en.wikipedia.org/wiki/Oral_manifestations_of_systemic_disease
Mihai NeteaMihai Netea
STAT1 mutations in autosomal dominant chronic mucocutaneous candidiasis. N Engl J Med. 2011 Jul 7;365(1):54-61 (47) Netea MG, ... "Genetic susceptibility to invasive fungal infections" (250.000 euro) 2010-2015 Vici Grant of the Netherlands Association for ... Chemokine Receptor CX3CR1 Modulates Susceptibility to Systemic Candidiasis in Mice and Humans. J. Clin. Invest. 2013; 123(12): ... "Pattern recognition receptors in disseminated candidiasis" (250.000 euro) 2007-2011 TI-Pharma consortium grant (500.000 euro). ...
https://en.wikipedia.org/wiki/Mihai_Netea
List of OMIM disorder codesList of OMIM disorder codes
ASPA Candidiasis, familial chronic mucocutaneous, autosomal dominant; 613108; CLEC7A Candidiasis, familial chronic ... invasive ductal; 114480; RAD54L Breast cancer, somatic; 114480; AKT1 Breast cancer, somatic; 114480; KRAS Breast cancer, ... GIF Invasive pneumococcal disease, recurrent isolated, 1; 610799; IRAK4 IRAK4 deficiency; 607676; IRAK4 Iridogoniodysgenesis, ...
https://en.wikipedia.org/wiki/List_of_OMIM_disorder_codes
Vaginal dischargeVaginal discharge
"Genital / vulvovaginal candidiasis (VVC) , Fungal Diseases , CDC". www.cdc.gov. Retrieved 2016-12-16. Barry L. Hainer; Maria V ... In fact, they can protect the individual from other infectious and invasive bacteria by producing substances such as lactic ... "Vulvovaginal Candidiasis - 2015 STD Treatment Guidelines". www.cdc.gov. 2019-01-11. "STD Facts - Trichomoniasis". www.cdc.gov. ... A vaginal yeast infection or vaginal candidiasis results from overgrowth of candida albicans, or yeast, in the vagina. This is ...
https://en.wikipedia.org/wiki/Vaginal_discharge
List of MeSH codes (C13)List of MeSH codes (C13)
... candidiasis, vulvovaginal MeSH C13.371.944.626 - pruritus vulvae MeSH C13.371.944.815 - vulvar lichen sclerosus MeSH C13.371. ... invasive MeSH C13.703.726.570 - fetal macrosomia MeSH C13.703.733.536 - pregnancy, abdominal MeSH C13.703.733.703 - pregnancy, ... candidiasis, vulvovaginal MeSH C13.703.039.089 - abortion, habitual MeSH C13.703.039.089.339 - uterine cervical incompetence ...
https://en.wikipedia.org/wiki/List_of_MeSH_codes_(C13)
Crohns diseaseCrohn's disease
Fungal infection such as candidiasis is also common due to the immunosuppression required in the treatment of the disease. ... September 2007). "Culture independent analysis of ileal mucosa reveals a selective increase in invasive Escherichia coli of ... Nickerson KP, McDonald C (2012). Mizoguchi E (ed.). "Crohn's disease-associated adherent-invasive Escherichia coli adhesion is ... Barnich N, Darfeuille-Michaud A (January 2007). "Adherent-invasive Escherichia coli and Crohn's disease". Current Opinion in ...
https://en.wikipedia.org/wiki/Crohn's_disease
Christine MaggioreChristine Maggiore
In fact, although invasive cervical cancer is an AIDS-defining illness, an abnormal Pap smear has never been an AIDS-defining ... with oral candidiasis as a contributing cause, all of which can be related to HIV infection. The death certificate also states ...
https://en.wikipedia.org/wiki/Christine_Maggiore
PfizerPfizer
By 2012, the rate of invasive infections among children under age 5 had been reduced by an additional 50%. In 2010, Ian Read ... the first oral treatment for severe fungal infections including candidiasis, blastomycosis, coccidiodomycosis, cryptococcosis, ... Toronto Invasive Bacterial Diseases Network. Archived from the original on May 16, 2022. Retrieved May 16, 2022. "Response ... this is used for the prevention of invasive pneumococcal infections. The introduction of the original, 7-valent version of the ...
https://en.wikipedia.org/wiki/Pfizer
IbrexafungerpIbrexafungerp
"Vulvovaginal Candidiasis - STI Treatment Guidelines". www.cdc.gov. 22 July 2021. Retrieved 6 April 2022. "Scynexis Announces ... and Isavuconazole for Treatment of Experimental Invasive Pulmonary Aspergillosis". Antimicrob Agents Chemother. 64 (6). doi: ... Placebo in Subjects With Acute Vulvovaginal Candidiasis (Vanish 306)" at ClinicalTrials.gov Portal: Medicine v t e (Articles ... Ibrexafungerp, sold under the brand name Brexafemme, is an antifungal medication used to treat vulvovaginal candidiasis (VVC) ( ...
https://en.wikipedia.org/wiki/Ibrexafungerp
FungusFungus
Money NP (1998). "Mechanics of invasive fungal growth and the significance of turgor in plant infection". Molecular Genetics of ... These include aspergillosis, candidiasis, coccidioidomycosis, cryptococcosis, histoplasmosis, mycetomas, and ...
https://en.wikipedia.org/wiki/Fungus
Invasive Candidiasis | Candidiasis | Types of Fungal Diseases | Fungal Diseases | CDCInvasive Candidiasis | Candidiasis | Types of Fungal Diseases | Fungal Diseases | CDC
Invasive candidiasis definition, symptoms, risk and prevention, sources of infection, diagnosis, treatment, information for ... Invasive candidiasis is an infection caused by a yeast (a type of fungus) called Candida. Unlike Candida infections in the ... invasive candidiasis is a serious infection that can affect the blood, heart, brain, eyes, bones, and other parts of the body. ...
https://www.cdc.gov/fungal/diseases/candidiasis/invasive/index.html
Epidemiology of Hospitalizations Associated with Invasive Candidiasis, United States, 2002-2012 - Volume 23, Number 1-January...
In addition, to avoid misclassification of noninvasive neonatal candidiasis as invasive candidiasis, we excluded records with ... Pfaller MA, Andes DR, Diekema DJ, Horn DL, Reboli AC, Rotstein C, et al. Epidemiology and outcomes of invasive candidiasis due ... for invasive candidiasis, specifically those records with disseminated candidiasis (code 112.5), candidal endocarditis (code ... of invasive candidiasis-associated hospitalizations were coded as disseminated candidiasis, 3% (4,253) as candidal endocarditis ...
https://wwwnc.cdc.gov/eid/article/23/1/16-1198
Basilea reports granting of U.S. orphan drug designation to isavuconazole for the treatment of invasive candidiasisBasilea reports granting of U.S. orphan drug designation to isavuconazole for the treatment of invasive candidiasis
Isavuconazole is a new drug in development for the treatment of invasive aspergillosis and invasive mucormycosis. Isavuconazole ... About invasive candidiasis. Infections by Candida yeasts are serious invasive fungal infections and are associated with high ... Basilea reports granting of U.S. orphan drug designation to isavuconazole for the treatment of invasive candidiasis. Basel, ... Achim Kaufhold, Basileas Chief Medical Officer, said: "Invasive candidiasis is a serious bloodstream infection that is ...
https://www.drugs.com/nda/isavuconazole_141103.html?utm_source=ddc&utm_medium=rss&utm_campaign=Basilea+reports+granting+of+U.S.+orphan+drug+designation+to+isavuconazole+for+the+treatment+of+invasive+candidiasis&utm_reader=feedly
Caspofungin for invasive candidiasis at a tertiary care medical center. | Scholars@DukeCaspofungin for invasive candidiasis at a tertiary care medical center. | [email protected]
Caspofungin for invasive candidiasis at a tertiary care medical center. ... had proven invasive candidiasis. There were 104 treatment courses for candidiasis in 99 patients available for review. ... Caspofungin for invasive candidiasis at a tertiary care medical center. Journal Article (Journal Article) ... Data on the use of caspofungin for treatment for invasive candidiasis are limited to clinical trials and case reports. We ...
https://scholars.duke.edu/display/pub733764
Initial therapeutic strategy of invasive candidiasis for intensive care unit patients: a retrospective analysis from the China...Initial therapeutic strategy of invasive candidiasis for intensive care unit patients: a retrospective analysis from the China...
The initial therapeutic strategy for invasive candidiasis was independently associated with hospital mortality. Prompt ... To investigate the impact of initial antifungal therapeutic strategies on the prognosis of invasive Candida infections (ICIs) ... Cui, N., Wang, H., Su, L. et al. Initial therapeutic strategy of invasive candidiasis for intensive care unit patients: a ... Management of invasive candidiasis and candidemia in adult non-neutropenic intensive care unit patients: Part I. Epidemiology ...
https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-017-2207-1
Clinical prediction rules for invasive candidiasis in the ICU: ready for prime time? | Critical Care | Full TextClinical prediction rules for invasive candidiasis in the ICU: ready for prime time? | Critical Care | Full Text
Invasive candidiasis is a major source of morbidity and mortality in critically ill patients. The creation and validation of ... Invasive candidiasis is a major source of morbidity and mortality in critically ill patients. The creation and validation of ... Ostrosky-Zeichner, L. Clinical prediction rules for invasive candidiasis in the ICU: ready for prime time?. Crit Care 15, 189 ( ... Clinical prediction rules for invasive candidiasis in the ICU: ready for prime time?. *Luis Ostrosky-Zeichner. 1 ...
https://ccforum.biomedcentral.com/articles/10.1186/cc10422
Invitro antifungal susceptibilities of Candida isolates from patients with invasive candidiasis in Kuala Lumpur Hospital,...Invitro antifungal susceptibilities of Candida isolates from patients with invasive candidiasis in Kuala Lumpur Hospital,...
The in vitro antifungal susceptibilities of 159 clinical isolates of Candida species from patients with invasive candidiasis in ... The in vitro antifungal susceptibilities of 159 clinical isolates of Candida species from patients with invasive candidiasis in ... In vitro antifungal susceptibilities of Candida isolates from patients with invasive candidiasis in Kuala Lumpur Hospital, ... Invitro antifungal susceptibilities of Candida isolates from patients with invasive candidiasis in Kuala Lumpur Hospital, ...
https://www.microbiologyresearch.org/content/journal/jmm/10.1099/jmm.0.027631-0
Empiric Antifungal Therapy for Candidiasis in PreemiesEmpiric Antifungal Therapy for Candidiasis in Preemies
... infants with invasive Candida helps avoid death and neurodevelopmental impairment. ... An Overlooked Cause of Preventable Deaths in the ICU: Invasive Fungal Infections 1.0 CME Credits ... When invasive Candida infection is suspected in adults with fever and neutropenia, empirical therapy (before blood culture ... Infectious Disease Society of America for the management of adult and pediatric patients with invasive and mucosal candidiasis ...
https://www.medscape.com/viewarticle/761472
Invasive Candidiasis Treatment | MIMS MalaysiaInvasive Candidiasis Treatment | MIMS Malaysia
See Invasive Candidiasis various therapeutic strategies, side effects and dosage guidelines , MIMS Malaysia ... Invasive Candidiasis. CNS. LFAmB (IV) ± Flucytosine (oral) followed by Fluconazole (IV/oral). Fluconazole (IV/oral) as step- ... First-line therapy for most episodes of candidemia and invasive candidiasis except for those infections in the CNS, eye and ... Early initiation of antifungal therapy with adequate source control is essential in the management of invasive candidiasis. * ...
https://specialty.mims.com/invasive%20candidiasis/treatment
IMSEAR at SEARO: Invasive candidiasis in pediatric intensive care units.
Invasive candidiasis in pediatric intensive care units. Indian Journal of Pediatrics. 2009 Oct; 76(10): 1033-1044. ... The incidence of invasive candidasis is on a steady rise because of increasing use of multiple antibiotics and invasive ... Treatment of candidiasis involves removal of the most likely source of infection and drug therapy to speed up the clearance of ... Candidemia and disseminated candidiasis are major causes of morbidity and mortality in hospitalized patients especially in the ...
https://imsear.searo.who.int/handle/123456789/142399
Candidiasis Infections: Yeast Infections, Thrush, Diaper RashCandidiasis Infections: Yeast Infections, Thrush, Diaper Rash
CDC: "Candidiasis," "Oropharyngeal/Esophageal Candidiasis," "Genital/vulvovaginal candidiasis (VVC)," "Invasive Candidiasis.". ... Invasive candidiasis is treated with an oral or intravenous dose of antifungal medication. If you are having surgery and have ... Invasive Candidiasis. If candida yeast enters the bloodstream (usually through medical equipment or devices), it can travel to ... Thrush (Oropharyngeal Candidiasis). When the candida yeast spreads in the mouth and throat, it can cause an infection called ...
https://www.webmd.com/skin-problems-and-treatments/guide/what-is-candidiasis-yeast-infection?page=3
Invasive CandidiasisInvasive Candidiasis
... is a life-threatening infection caused by the fungus Candida albicans. Invasive ... Current diagnosis of invasive candidiasis is based on a reactive user - any patient with fever of unknown origin who does not ... Identification of invasive candidiasis by culture requires the one thing a clinician cannot afford - time. A delay in treatment ... There are over 60,000 cases of invasive candidiasis in the United States each year. Some reports estimate the annual health- ...
http://www.dxdiscovery.com/invasive-candidiasis.html
Invasive candidiasis in Pakistan: clinical characteristics, species distribution and antifungal susceptibilityInvasive candidiasis in Pakistan: clinical characteristics, species distribution and antifungal susceptibility
Candidiasis, Invasive Child Child, Preschool Drug Resistance, Fungal Female Humans Infant Infant, Newborn Male Microbial ... Risk factors for invasive candidiasis (IC) were determined for 96 patients from Karachi, Pakistan. In adults and neonates, ... Title : Invasive candidiasis in Pakistan: clinical characteristics, species distribution and antifungal susceptibility Personal ... Candida auris is an invasive healthcare-associated fungal pathogen. Cases of candidemia, defined as illness in patients with ...
https://stacks.cdc.gov/view/cdc/36361
Figure 1 - Epidemiology of Hospitalizations Associated with Invasive Candidiasis, United States, 2002-2012 - Volume 23, Number...
Pfaller MA, Andes DR, Diekema DJ, Horn DL, Reboli AC, Rotstein C, et al. Epidemiology and outcomes of invasive candidiasis due ... Invasive candidiasis. Infect Dis Clin North Am. 2006;20:485-506. DOIPubMedGoogle Scholar ... Invasive Candidiasis. N Engl J Med. 2015;373:1445-56. DOIPubMedGoogle Scholar ... Epidemiology and risk factors for invasive candidiasis. Ther Clin Risk Manag. 2014;10:95-105. DOIPubMedGoogle Scholar ...
https://wwwnc-origin.cdc.gov/eid/article/23/1/16-1198-f1
Epidemiology of Hospitalizations Associated with Invasive Candidiasis, United States, 2002-2012 - Volume 23, Number 1-January...
In addition, to avoid misclassification of noninvasive neonatal candidiasis as invasive candidiasis, we excluded records with ... Pfaller MA, Andes DR, Diekema DJ, Horn DL, Reboli AC, Rotstein C, et al. Epidemiology and outcomes of invasive candidiasis due ... for invasive candidiasis, specifically those records with disseminated candidiasis (code 112.5), candidal endocarditis (code ... of invasive candidiasis-associated hospitalizations were coded as disseminated candidiasis, 3% (4,253) as candidal endocarditis ...
https://wwwnc-origin.cdc.gov/eid/article/23/1/16-1198
Chronic Mucocutaneous Candidiasis Medication: AntifungalsChronic Mucocutaneous Candidiasis Medication: Antifungals
Chronic mucocutaneous candidiasis (CMC) refers to a heterogeneous group of disorders characterized by recurrent or persistent ... Invasive fungal infection and impaired neutrophil killing in human CARD9 deficiency. Blood. 2013 Mar 28. 121 (13):2385-92. [ ... encoded search term (Chronic Mucocutaneous Candidiasis) and Chronic Mucocutaneous Candidiasis What to Read Next on Medscape ... Clinical heterogeneity of dominant chronic mucocutaneous candidiasis disease: presenting as treatment-resistant candidiasis and ...
https://emedicine.medscape.com/article/1091928-medication
Yeast Infection Tests: MedlinePlus Medical TestYeast Infection Tests: MedlinePlus Medical Test
... www.cdc.gov/fungal/diseases/candidiasis/invasive/index.html. *Centers for Disease Control and Prevention [Internet]. Atlanta: U ... Candidiasis, candidosis, and moniliasis are other names for a yeast infection.. Normally, yeast doesnt cause problems. But if ... If your provider thinks you may have an invasive yeast infection in your blood or organs, you may have a fungal culture test or ... Candidiasis. StatPearls Publishing [Internet]. Treasure Island (FL): [last update 2022 Feb 12; cited 2022 Mar 9]; [about 8 ...
https://medlineplus.gov/lab-tests/yeast-infection-tests/
Neonatal invasive candidiasis in low- and middle-income countries: Data from the NeoOBS study. | Med Mycol;61(3)2023 Mar 02. ...Neonatal invasive candidiasis in low- and middle-income countries: Data from the NeoOBS study. | Med Mycol;61(3)2023 Mar 02. ...
Neonatal invasive candidiasis (NIC) has significant morbidity and mortality. Reports have shown a different profile of those ... Our study describes neonates from low- and middle-income countries with neonatal invasive candidiasis (NIC). Most of them were ... Neonatal invasive candidiasis in low- and middle-income countries: Data from the NeoOBS st ... Neonatal invasive candidiasis in low- and middle-income countries: Data from the NeoOBS study. ...
https://pesquisa.bvsalud.org/brasil/resource/pt/mdl-36881725
Micafungin versus caspofungin for treatment of candidemia and other forms of invasive candidiasis (Clinical Infectious Diseases...
T1 - Micafungin versus caspofungin for treatment of candidemia and other forms of invasive candidiasis (Clinical Infectious ... Micafungin versus caspofungin for treatment of candidemia and other forms of invasive candidiasis (Clinical Infectious Diseases ... Micafungin versus caspofungin for treatment of candidemia and other forms of invasive candidiasis (Clinical Infectious Diseases ... Micafungin versus caspofungin for treatment of candidemia and other forms of invasive candidiasis (Clinical Infectious Diseases ...
https://augusta.pure.elsevier.com/en/publications/micafungin-versus-caspofungin-for-treatment-of-candidemia-and-oth
American Journal of Case Reports | Sudden Esophageal Necrosis and Mediastinitis Associated with Invasive Candidiasis: A Case...American Journal of Case Reports | Sudden Esophageal Necrosis and Mediastinitis Associated with Invasive Candidiasis: A Case...
... associated with invasive candidiasis. Diagnosis was challenging owing to the rarity of the condition. The patient required ... Acute esophageal necrosis associated with invasive Candida sp. infection is even more infrequent, with only a few cases ... 27.. Gock M, Schäfer M, Perren A, Fatal esophageal perforation caused by invasive candidiasis: Ann Thorac Surg, 2005; 80(3); ... 31.. Aghdam F, Sund S, Invasive esophageal candidiasis with chronic mediastinal abscess and fatal pneumomediastinum: Am J Case ...
https://amjcaserep.com/abstract/full/idArt/928394
Françoise Van Bambeke | UCLouvainFrançoise Van Bambeke | UCLouvain
Existing and emerging therapies for the treatment of invasive candidiasis and candidemia. In: Expert Opinion on Emerging Drugs ... Molecular Analysis of Rising Fluoroquinolone Resistance in Belgian Non-Invasive Streptococcus pneumoniae Isolates (1995-2014). ...
https://uclouvain.be/en/directories/francoise.vanbambeke
1993 Revised Classification System for HIV Infection and Expanded Su1993 Revised Classification System for HIV Infection and Expanded Su
Candidiasis of bronchi, trachea, or lungs *Candidiasis, esophageal *Cervical cancer, invasive * *Coccidioidomycosis, ... Candidiasis of esophagus. a. Recent onset of retrosternal pain on swallowing; AND b. Oral candidiasis diagnosed by the gross ... Candidiasis, oropharyngeal (thrush) *Candidiasis, vulvovaginal; persistent, frequent, or poorly responsive to therapy *Cervical ... In contrast, the diagnosis of invasive cervical cancer is generally unequivocal.. Invasive cervical cancer is preventable by ...
https://wonder.cdc.gov/wonder/prevguid/m0018871/m0018871.asp
JoF | Free Full-Text | Candida spp./Bacteria Mixed BiofilmsJoF | Free Full-Text | Candida spp./Bacteria Mixed Biofilms
... the drug had efficacy in invasive candidiasis, aspergillosis, and pneumocystis. High bioavailability, positive drug interaction ... This article belongs to the Special Issue Pathogenesis of Candidiasis). Download Download PDF Download PDF with Cover Download ... Among Candida spp., C. albicans is effectively the most predominant cause of invasive fungal infections and is a serious ... Apart from their role as the main etiology for various types of candidiasis, Candida spp. are also related to polymicrobial ...
https://www.mdpi.com/2309-608X/6/1/5
Review of the guidelines for the treatment and prevention of invasive candidiasis in newborns and children | CMACReview of the guidelines for the treatment and prevention of invasive candidiasis in newborns and children | CMAC
Among older children, by analogy with adults, the key risk groups for the development of invasive candidiasis are severely ill ... Intentionally in the article are not covered issues of diagnosis of invasive candidiasis, as well as the peculiarities of the ... The choice of drugs for the treatment of invasive candidiasis in children, especially in infants, requires a very balanced ... This review will summarize approaches to the treatment and prevention of invasive fungal infections caused *Candida spp.* in ...
https://cmac-journal.ru/en/publication/2017/2/cmac-2017-t19-n2-p092/
White CM[au] - Search Results - PubMedWhite CM[au] - Search Results - PubMed
Candidemia and Invasive Candidiasis. McCarty TP, White CM, Pappas PG. McCarty TP, et al. Among authors: white cm. Infect Dis ...
https://pubmed.ncbi.nlm.nih.gov/?cmd=search&term=White+CM%5Bau%5D&dispmax=50
Nosocomial infection: What is it, types, and moreNosocomial infection: What is it, types, and more
Symptoms of invasive candidiasis. (2020).. https://www.cdc.gov/fungal/diseases/candidiasis/invasive/symptoms.html. ... Fungal: Mold infections and candidiasis are common causes of nosocomial infections. They most often lead to UTIs and ... some of the many invasive procedures and devices involved in modern healthcare can contribute to the spread of infection. These ...
https://www.medicalnewstoday.com/articles/nosocomial-infection?utm_source=ReadNext
Download The Official Patient\\\'s Sourcebook On Invasive Candidiasis: A Revised And Updated Directory For The Internet Age
Why are I declare to be a CAPTCHA? This download the official patient\s sourcebook on invasive candidiasis: a revised and ... Download The Official Patient\\s Sourcebook On Invasive Candidiasis: A Revised And Updated Directory For The Internet Age. by ... The including download the official patient\s sourcebook on invasive candidiasis: a revised for e-book V week learning may run ... The being download the official patient\s sourcebook on invasive candidiasis: a revised and updated directory for the of a ...
http://peterkim.com/ebooks/ebooks/download-the-official-patient%27s-sourcebook-on-invasive-candidiasis%3A-a-revised-and-updated-directory-for-the-internet-age.html
Emerging Infectious Diseases - CDCEmerging Infectious Diseases - CDC
Increasing Incidence of Invasive Group A Streptococcus Disease, Idaho, USA, 2008-2019 [PDF - 1.24 MB - 11 pages] E. M. Dunne et ... Compared with younger patients, fungal infection diagnosis rates, particularly for candidiasis, were elevated among persons ,65 ... Invasive Group A Streptococcus Outbreaks Associated with Home Healthcare, England, 2018-2019 [PDF - 854 KB - 9 pages] L. E. ... Pediatric Invasive Meningococcal Disease, Auckland, New Zealand (Aotearoa), 2004-2020 C. Burton et al. View Abstract. ...
http://cdc.gov/eid
HIV and AIDS Information | thirdAGE
Candidiasis. of bronchi, trachea, esophagus, or lungs. *. Invasive cervical cancer. *. Coccidioidomycosis. *. Cryptococcosis. ...
https://thirdage.com/condition/aidshiv-2/
CandidaInfectionsAspergillosisInfectionCandidemia and invasiveProven invasive candidiasisCommon invasive fungalNosocomialSystemicOropharyngealDiagnosisPediatricIncidence of invasive candidiasisManagement of invasive candidiasisProphylaxisNeonatalClinicalPathogensMorbidity and mortaRisk factors for invasiveCaspofunginCutaneous CandidiasisEsophagealCases of invasiveSuperficialTreatmentAmphotericinPulmonaryICUsIntensiveNoncultureOralHospital2002
Candida30
  • Invasive candidiasis is an infection caused by a yeast (a type of fungus) called Candida. (cdc.gov)
  • Unlike Candida infections in the mouth and throat (also called "thrush") or vaginal "yeast infections," invasive candidiasis is a serious infection that can affect the blood, heart, brain, eyes, bones, and other parts of the body. (cdc.gov)
  • Candida species are associated with invasive fungal infections among at-risk groups and have been ranked seventh as a cause of nosocomial bloodstream infection in the United States and elsewhere ( 4 - 6 ). (cdc.gov)
  • Basel, Switzerland, November 3, 2014 - Basilea Pharmaceutica Ltd. reports today that the U.S. Food and Drug Administration (FDA) has granted orphan drug designation to isavuconazole for the treatment of invasive candidiasis/candidemia, a potentially life-threatening infection caused by Candida yeasts. (drugs.com)
  • Infections by Candida yeasts are serious invasive fungal infections and are associated with high morbidity and mortality. (drugs.com)
  • Isavuconazole for the treatment of candidiasis is currently explored in the phase 3 study ACTIVE, which evaluates the safety and efficacy of intravenously (i.v.) and orally administered isavuconazole versus i.v. caspofungin followed by oral voriconazole in the treatment of invasive Candida infections. (drugs.com)
  • To investigate the impact of initial antifungal therapeutic strategies on the prognosis of invasive Candida infections (ICIs) in intensive care units (ICUs) in China. (biomedcentral.com)
  • The in vitro antifungal susceptibilities of 159 clinical isolates of Candida species from patients with invasive candidiasis in Kuala Lumpur Hospital, Malaysia, were determined against amphotericin B, fluconazole, voriconazole, itraconazole and caspofungin. (microbiologyresearch.org)
  • Genetic relatedness of Candida strains isolated from women with vaginal candidiasis in Malaysia. (microbiologyresearch.org)
  • NEW YORK (Reuters Health) Apr 03 - Empiric therapy in extremely low birth weight (ELBW) infants with invasive Candida helps avoid death and neurodevelopmental impairment, according to retrospective data from the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. (medscape.com)
  • When invasive Candida infection is suspected in adults with fever and neutropenia, empirical therapy (before blood culture results are available or in the face of a negative result) has been shown to improve outcomes. (medscape.com)
  • Yet, there are no randomized trials evaluating empiric therapy for infants at high risk of invasive Candida infections, Dr. Smith said, "and previous studies of empiric therapy were small. (medscape.com)
  • Invasive candidiasis is a life-threatening infection caused by the fungus Candida albicans . (dxdiscovery.com)
  • DxDiscovery aims to use Candida biomarkers as a surrogate for detection of the C. albicans organism in a manner that is low-cost, non-invasive, and delivers rapid results. (dxdiscovery.com)
  • The spectrum of infection with candida species range from superficial candidiasis of the skin and mucosa to more serious life threatening infections. (who.int)
  • Persistent and refractory candidal infections, which characterize chronic mucocutaneous candidiasis (CMC), must be distinguished from the more common and treatment-responsive overgrowth of Candida that occurs in the setting of systemic antibiotic therapy, local/systemic corticosteroid treatment, or hyperglycemia in persons with diabetes mellitus. (medscape.com)
  • They note purulent pericarditis due to Candida represents 1% of cases of purulent pericarditis, according to one review of 660 cases of invasive pericarditis (2). (medpagetoday.com)
  • Acute esophageal necrosis associated with invasive Candida sp. (amjcaserep.com)
  • Epidemiology and outcomes of invasive candidiasis due to non-albicans species of Candida in 2,496 patients: data from the Prospective Antifungal Therapy (PATH) registry 2004-2008. (cdc.gov)
  • nvasive infections caused by Candida species are the most common invasive fungal infections in children of different age groups. (cmac-journal.ru)
  • 2010). Limited role of secreted aspartyl proteinases Sap1 to Sap6 in Candida albicans virulence and host immune response in murine hematogenously disseminated candidiasis . (up.pt)
  • Chronic mucocutaneous candidiasis describes a group of Candida infections of the skin, hair, nails, and mucous membranes that tends to have a protracted and persistent course. (medscape.com)
  • Excess of Candida albicans causes candidiasis, causative of thrush and vaginal infection due to off-balance. (simulations-plus.com)
  • Candida infections of the latter category are also referred to as candidemia or invasive candidiasis , and are usually confined to severely immunocompromised persons, such as cancer, transplant, and AIDS patients, as well as nontrauma emergency surgery patients. (empowher.com)
  • Treatment of candidiasis is challenged by the emerging resistance of Candida species. (uwc.ac.za)
  • You may have heard of candida, or candidiasis. (saturnaliathebook.com)
  • Candida auris is an emerging multidrug-resistant (MDR) yeast that can cause invasive infections and is associated with high mortality. (cdc.gov)
  • Known risk factors for C. auris infection are similar to those for invasive Candida infection in general, including central venous catheter use, recent surgery, diabetes, and recent broad-spectrum antibiotic or antifungal use. (cdc.gov)
  • The Candida strains were also injected into Galleria mellonella larvae to induce experimental candidiasis, and after 24 hours, the survival rate was assessed. (bvsalud.org)
  • The pathogenic mechanisms of Candida yeasts and fungus-host interactions have been studied in rat and mouse experimental models of candidiasis 7-11 . (bvsalud.org)
Infections26
  • Isavuconazole (active moiety of the prodrug isavuconazonium sulfate) is an investigational once-daily intravenous and oral broad-spectrum antifungal for the potential treatment of life-threatening invasive fungal infections which predominantly occur in immunocompromised patients such as cancer patients undergoing chemotherapy. (drugs.com)
  • Invasive fungal infection (IFI) is one of the most common in opportunistic infections for critically ill patients [ 1 ]. (biomedcentral.com)
  • Chronic mucocutaneous candidiasis (CMC) is diagnosed based on physical examination findings, potassium chloride (KOH) preparation results, fungal culture, and a history of recurrent and refractory candidiasis infections. (medscape.com)
  • 12. Wiley J., Seibel N., Walsh T. Efficacy and safety of amphotericin B lipid complex in 548 children and adolescents with invasive fungal infections. (cmac-journal.ru)
  • Amphotericin B lipid complex in pediatric patients with invasive fungal infections. (cmac-journal.ru)
  • Secondary localizations complicating invasive infections are poorly described. (cdc.gov)
  • Patients with histoplasmosis or other invasive fungal infections may present with disseminated, rather than localized, disease. (rxlist.com)
  • Empiric anti-fungal therapy should be considered in patients at risk for invasive fungal infections who develop severe systemic illness. (rxlist.com)
  • as the cause of nosocomial (hospital-acquired) invasive fungal infections, is first and foremost a pulmonary pathogen causing aspergillomas (fungus balls) that occlude the lung cavities. (exeter.ac.uk)
  • have long been associated with infections of the skin, nail and cornea, but are now becoming increasingly recognized as a cause of invasive fungal infection (fusariosis) in neutropenic patients and in those undergoing transplantation. (exeter.ac.uk)
  • Scedosporium apiospermum is a well known causative agent of mycetoma (tumour-like swellings with draining sinuses), but this species and the pathogen Lomentospora prolificans (formerly Scedosporium prolificans ) have also recently emerged as significant invasive pathogens, particularly of immunocompromised patients, and now account for ~25% of non- Aspergillus infections in high risk patient groups. (exeter.ac.uk)
  • After incidence of candidemia and invasive aspergillosis in COVID-19 patients increased ( 4 , 5 ), awareness of possible fungal co-infections increased among clinicians and microbiologists. (cdc.gov)
  • One study reported invasive fungal infections in ≈6% of hospitalized COVID-19 patients ( 6 ). (cdc.gov)
  • We explored the anti-HMGB1 effects of EP, which may be of benefit in the diagnosis and treatment of invasive C. albicans infections. (researchsquare.com)
  • We suggest that HMGB1 plays a vital role in invasive C. albicans infections and may provide an effective diagnostic and therapeutic target for such infections in clinical settings. (researchsquare.com)
  • Voriconazole in the treatment of aspergillosis, scedosporiosis and other invasive fungal infections in children. (nursingcenter.com)
  • Schering-Plough said today the European Commission had granted marketing approval for its Noxafil drug to treat oropharyngeal candidiasis, a fungal infection in the mouth, as well as for preventing invasive fungal infections. (pharmatimes.com)
  • Noxafil (posaconazole) debuted in Germany last November after being approved as a treatment for invasive fungal infections, and the new indications dramatically increase the potential patient population addressed by the product. (pharmatimes.com)
  • Specifically, Noxafil has been cleared in the EU for the prevention of invasive fungal infections in high-risk patients, including those whose immune systems are compromised by haematological cancers or immunosuppressive therapies, and as a first-line treatment for oropharyngeal candidiasis in patients who are immunocompromised or who have severe disease. (pharmatimes.com)
  • In the USA Noxafil is already cleared for the treatment and prevention of invasive fungal infections and for oropharyngeal candidiasis. (pharmatimes.com)
  • A recent report by market research company Datamonitor suggested that the worldwide market for systemic antifungal drugs will grow from a level of around $3.3 billion in 2003 to almost $6 billion by 2014, driven by an increased incidence and severity of invasive fungal infections, combined with the launch of novel, premium priced antifungal products. (pharmatimes.com)
  • Noxafil is well placed because it is the only antifungal agent approved for the prevention of invasive fungal infections caused by Aspergillus , an increasingly common pathogen. (pharmatimes.com)
  • Despite being responsible for invasive infections, fungal pathogens have been underrepresented in computer aided therapeutic target mining and drug design. (simulations-plus.com)
  • Candidiasis encompasses infections that range from superficial, such as oral thrush and vaginitis, to systemic and potentially life-threatening diseases. (empowher.com)
  • Background: Type 2 diabetes mellitus (T2DM) predisposes patients to opportunistic infections, such as invasive candidiasis. (uwc.ac.za)
  • Other invasive infections, such as intraabdominal candidiasis, and meningitis can also occur. (cdc.gov)
Aspergillosis6
  • Isavuconazole has previously been granted orphan drug status in the European Union and the U.S. for the treatment of invasive aspergillosis and mucormycosis. (drugs.com)
  • Previously, the FDA also designated isavuconazole as a Qualified Infectious Disease Product (QIDP) for the treatment of invasive aspergillosis, mucormycosis and candidiasis under the Generating Antibiotic Incentives Now (GAIN) Act. (drugs.com)
  • Isavuconazole is currently under regulatory review by the U.S. FDA and the European Medicines Agency (EMA) for the treatment of invasive aspergillosis and mucormycosis in adults. (drugs.com)
  • Voriconazole versus amphotericin B for primary therapy of invasive aspergillosis. (semanticscholar.org)
  • Treatment of invasive aspergillosis in patients who are refractory to or intolerant of other therapies. (nih.gov)
  • However, the fungus can also invade the host via lung tissue resulting in a disease known as invasive aspergillosis. (exeter.ac.uk)
Infection15
  • Prof. Achim Kaufhold, Basilea's Chief Medical Officer, said: "Invasive candidiasis is a serious bloodstream infection that is associated with high morbidity and mortality. (drugs.com)
  • Discriminating invasive fungal infection from colonization. (microbiologyresearch.org)
  • The infection it causes is called candidiasis . (webmd.com)
  • Invasive candidiasis is a serious problem in the hospital setting and is the most common invasive fungal infection in countries with advanced medical care. (dxdiscovery.com)
  • Current diagnosis of invasive candidiasis is based on a reactive user - any patient with fever of unknown origin who does not respond to antibiotic treatment for bacterial infection is suspected to have invasive candidiasis. (dxdiscovery.com)
  • Treatment of candidiasis involves removal of the most likely source of infection and drug therapy to speed up the clearance of infection. (who.int)
  • Candidiasis, candidosis, and moniliasis are other names for a yeast infection. (medlineplus.gov)
  • This is called an invasive yeast infection. (medlineplus.gov)
  • If your provider thinks you may have an invasive yeast infection in your blood or organs, you may have a fungal culture test or other tests on a sample of blood, other fluid, or tissue from the part of your body that may be infected. (medlineplus.gov)
  • According to the Centers for Disease Control and Prevention (CDC) , some of the many invasive procedures and devices involved in modern healthcare can contribute to the spread of infection. (medicalnewstoday.com)
  • One of the most common types, a vaginal infection, goes by names that include yeast vaginitis, vulvovaginal candidiasis, and candidal vaginitis. (verywellhealth.com)
  • Therefore, we investigated HMGB1 mRNA and protein levels in serum and tissue from patients and mice with invasive C. albicans infection. (researchsquare.com)
  • The incidence of invasive fungal infection (IFI), more than 50% of which is caused by C. albicans , has been steadily increasing and is the fourth most common cause of nosocomial bloodstream infection. (researchsquare.com)
  • Invasive candidiasis occurs when candidiasis goes beyond a superficial infection and manifests as CANDIDEMIA , deep tissue infection, or disseminated disease with deep organ involvement. (bvsalud.org)
  • A person with a screening/surveillance case can later be categorized as having a clinical case (e.g., asymptomatic person with skin colonization who later develops invasive infection would be counted in both categories). (cdc.gov)
Candidemia and invasive1
  • Candidemia and Invasive Candidiasis. (nih.gov)
Proven invasive candidiasis3
  • RESULTS: Of 241 patients receiving caspofungin for all indications, 122 (51%) had proven invasive candidiasis. (duke.edu)
  • A decrease in levels during therapy has been associated with treatment success in patients on echinocandin therapy with proven invasive candidiasis. (medscape.com)
  • This multinational observational cohort study enrolled patients aged >120 days and <18 years with proven invasive candidiasis from January 1, 2014, to November 28, 2017, at 43 International Pediatric Fungal Network sites. (chop.edu)
Common invasive fungal1
  • Invasive candidiasis is the most common invasive fungal disease in children and adolescents, but there are limited pediatric-specific antifungal effectiveness data. (chop.edu)
Nosocomial1
  • Invasive candidiasis is a major nosocomial fungal disease in the United States associated with high rates of illness and death. (cdc.gov)
Systemic3
  • Systemic candidiasis and invasive fungal dermatitis, although rare, usually occur in premature infants, particularly those with extremely low birth weight. (medscape.com)
  • Patients were checked for systemic candidiasis. (who.int)
  • This chapter is referred mainly to systemic and invasive forms of candidiasis. (medscape.com)
Oropharyngeal1
  • Currently, no strong indications exist for primary or secondary prevention of oropharyngeal candidiasis (OPC) or vaginal candidiasis in patients infected with HIV. (medscape.com)
Diagnosis4
  • This innovation will introduce a new paradigm in the diagnosis of invasive candidiasis. (dxdiscovery.com)
  • Intentionally in the article are not covered issues of diagnosis of invasive candidiasis, as well as the peculiarities of the clinical pharmacology of antifungal drugs in children, but can be found in several copmprehensive literature reviews. (cmac-journal.ru)
  • Gram stain is a valuable method in rapid accurate diagnosis of symptomatic VVC and even superior to culture as it demonstrates the invasive forms of the yeast. (who.int)
  • 1,3)β-D-glucan assay is a useful nonculture method for diagnosis of invasive candidiasis. (medscape.com)
Pediatric5
  • The authors note in their report that the most recent guidelines from the Infectious Disease Society of America for the management of adult and pediatric patients with invasive and mucosal candidiasis do not address the issue of empiric therapy in infants. (medscape.com)
  • IMSEAR at SEARO: Invasive candidiasis in pediatric intensive care units. (who.int)
  • 5. Roilides E., Kadiltsoglou I., Zahides D., Bibashi E. Invasive candidosis in pediatric patients. (cmac-journal.ru)
  • Micafungin versus liposomal amphotericin B for pediatric patients with invasive candidiasis: Substudy of a randomized double-blind trial. (cmac-journal.ru)
  • For a more detailed discussion, several others chapter are available at emedicine.medscape.com (cutaneous candidiasis, mucosal candidiasis, chronic mucocutaneous candidiasis, pediatric candidiasis, candidiasis in emergency medicine). (medscape.com)
Incidence of invasive candidiasis3
  • We analyzed inpatient hospitalization records from the Healthcare Cost and Utilization Project to estimate incidence of invasive candidiasis-associated hospitalizations in the United States. (cdc.gov)
  • Case authors suggest that the increasing complexity of patients has contributed to a growing incidence of invasive candidiasis, and potential mortality, especially in hospitalized patients (5). (medpagetoday.com)
  • Most recent candidiasis treatment guidelines recommend prophylaxis in high-risk ICU patients in adult units that have high incidence of invasive candidiasis. (medscape.com)
Management of invasive candidiasis2
  • Early initiation of antifungal therapy w/ adequate source control is essential in the management of invasive candidiasis. (mims.com)
  • Regular investigations into antifungal resistance in medical centres is highly recommended as this will result in more efficient management of invasive candidiasis in immunocompromised patients. (who.int)
Prophylaxis4
  • Solid organ transplant recipients may be considered for antifungal prophylaxis with fluconazole or liposomal amphotericin B for the prevention of candidiasis. (medscape.com)
  • This is recommended for postoperative antifungal prophylaxis in liver, pancreas, and small bowel transplant recipients at high risk of candidiasis. (medscape.com)
  • Prophylaxis may be indicated in a select group of patients with recurrent symptomatic candidiasis. (medscape.com)
  • Changes from the 2017 CPG included two conditional recommendations regarding (1) discontinuation of empiric antibacterial therapy in clinically well and afebrile patients with low-risk FN if blood cultures remain negative at 48 hours despite no evidence of marrow recovery and (2) pre-emptive antifungal therapy for invasive fungal disease in high-risk patients not receiving antimold prophylaxis. (chop.edu)
Neonatal2
  • Neonatal invasive candidiasis in low- and middle-income countries: Data from the NeoOBS study. (bvsalud.org)
  • E. Neonatal Candidiasis review: Bliss JM, Wellington M, Gigliotti F. Antifungal pharmacotherapy for neonatal candidiasis. (nursingcenter.com)
Clinical6
  • Data on the use of caspofungin for treatment for invasive candidiasis are limited to clinical trials and case reports. (duke.edu)
  • CONCLUSIONS: The clinical use of caspofungin has been successful in the treatment of invasive candidiasis, even in patients with prior antifungal exposure. (duke.edu)
  • In this unselected review, caspofungin performed similarly as in clinical trials, and clinicians should consider caspofungin as first-line therapy for invasive candidiasis, particularly non-albicans species. (duke.edu)
  • Clinical prediction rules for invasive candidiasis in the ICU: ready for prime time? (biomedcentral.com)
  • In the previous issue of Critical Care , Hermsen and colleagues [ 1 ] presented a validation of two clinical prediction rules for invasive candidiasis (IC) and propose a new one based on common risk factors found in ICU patients. (biomedcentral.com)
  • Candidiasis can cause a wide spectrum of clinical syndromes, as described below. (medscape.com)
Pathogens1
  • The frequency of invasive mycoses by opportunistic fungal pathogens has increased dramatically over the past two decades. (exeter.ac.uk)
Morbidity and morta2
  • Invasive candidiasis is a major source of morbidity and mortality in critically ill patients. (biomedcentral.com)
  • Candidemia and disseminated candidiasis are major causes of morbidity and mortality in hospitalized patients especially in the intensive care units (ICU). (who.int)
Risk factors for invasive1
  • Yapar N . Epidemiology and risk factors for invasive candidiasis. (cdc.gov)
Caspofungin6
  • Caspofungin for invasive candidiasis at a tertiary care medical center. (duke.edu)
  • BACKGROUND: Caspofungin is emerging as first-line therapy for invasive candidiasis. (duke.edu)
  • We report a single-center experience with 104 consecutive courses of caspofungin for the treatment of invasive candidiasis to evaluate a real-world performance of this drug. (duke.edu)
  • Caspofungin did not clear candidiasis in 14 episodes (microbiologic cure rate 75%, 42/56). (duke.edu)
  • Initial treatment of invasive candidiasis in non-neutropenic patients involves an echinocandin such as anidulafungin (200 mg loading dose, then 100 mg IV daily), caspofungin (70 mg loading dose, then 50 mg IV daily), and micafungin (100 mg IV daily). (medpagetoday.com)
  • Comparison of caspofungin and amphotericin B for invasive candidiasis. (semanticscholar.org)
Cutaneous Candidiasis1
  • Generalized cutaneous candidiasis: This is an unusual form of cutaneous candidiasis that manifests as a diffuse eruption over the trunk, thorax, and extremities. (medscape.com)
Esophageal3
  • We present the case of a 37-year-old man with idiopathic chronic renal failure who presented to the Emergency Department with sudden esophageal necrosis and mediastinitis, associated with invasive candidiasis. (amjcaserep.com)
  • Administer a single 70-mg loading dose on Day 1, followed by 50 mg once daily for all indications except esophageal candidiasis. (nih.gov)
  • For esophageal candidiasis, use 50 mg once daily with no loading dose. (nih.gov)
Cases of invasive1
  • There are over 60,000 cases of invasive candidiasis in the United States each year. (dxdiscovery.com)
Superficial1
  • La candidiasis invasiva ocurre cuando la infección superficial progresa y se presenta CANDIDEMIA, infecciones tisulares profundas con enfermedad diseminada y afectación de órganos internos. (bvsalud.org)
Treatment3
  • There were 104 treatment courses for candidiasis in 99 patients available for review. (duke.edu)
  • The patient is started on fluconazole 800 mg/day as a loading dose, then 400 mg/day for 2-3 weeks, as recommended for the treatment of invasive candidiasis. (medpagetoday.com)
  • The choice of drugs for the treatment of invasive candidiasis in children, especially in infants, requires a very balanced approach, due to the physiological characteristics of the child's organism, the peculiarities of the flow of infectious process, differences in the pharmacokinetics parametes of drugs, as well as the registered indications for the use of a drug in a specific country including age restrictions. (cmac-journal.ru)
Amphotericin4
  • Safety, tolerance, and pharmacokinetics of amphotericin B lipid complex in children with hepatosplenic candidiasis. (cmac-journal.ru)
  • Comparative Effectiveness of Echinocandins vs Triazoles or Amphotericin B Formulations as Initial Directed Therapy for Invasive Candidiasis in Children and Adolescents. (chop.edu)
  • We compared the effectiveness of echinocandins to triazoles or amphotericin B formulations (triazole/amphotericin B) as initial directed therapy for invasive candidiasis. (chop.edu)
  • Exposure groups were categorized by receipt of an echinocandin vs receipt of triazole/amphotericin B. Primary outcome was global response at 14 days following invasive candidiasis onset, adjudicated by a centralized data review committee. (chop.edu)
Pulmonary1
  • Under a magnification of 125X, this photomicrograph of a hematoxylin-eosin (H&E)-stained lung tissue specimen, revealed the histopathologic changes found in a patient diagnosed with invasive pulmonary candidiasis. (cdc.gov)
ICUs2
  • The incidence of invasive candidasis is on a steady rise because of increasing use of multiple antibiotics and invasive procedures carried out in the ICUs. (who.int)
  • Incidence and outcome of invasive candidiasis in intensive care units (ICUs) in Europe: results of the EUCANDICU project. (uni-koeln.de)
Intensive3
  • Patients with the highest risk of developing invasive candidiasis are those who have extended stays at intensive care units, long-term catheterization, solid organ transplantation, and immunodeficiency. (dxdiscovery.com)
  • Among older children, by analogy with adults, the key risk groups for the development of invasive candidiasis are severely ill patients in intensive care units, as well as children with hematologic malignancies with immunosuppression. (cmac-journal.ru)
  • Developing definitions for invasive fungal diseases in critically ill adult patients in intensive care units. (uni-koeln.de)
Nonculture1
  • Clancy CJ, Nguyen MH (2013) Finding the "missing 50%" of invasive candidiasis: how nonculture diagnostics will improve understanding of disease spectrum and transform patient care. (revuesonline.com)
Oral1
Hospital2
  • The initial therapeutic strategy for invasive candidiasis was independently associated with hospital mortality. (biomedcentral.com)
  • The incidence of hospital-acquired, invasive candidiasis increased 10-fold over the decade of the 1980s. (cdc.gov)
20021
  • Average annual invasive candidiasis−associated hospitalizations, United States, 2002−2012. (cdc.gov)
Invasive Candidiasis | Candidiasis | Types of Fungal Diseases | Fungal Diseases | CDC
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