Infection with a fungus of the genus CANDIDA. It is usually a superficial infection of the moist areas of the body and is generally caused by CANDIDA ALBICANS. (Dorland, 27th ed)
Infection of the mucous membranes of the mouth by a fungus of the genus CANDIDA. (Dorland, 27th ed)
Infection of the VULVA and VAGINA with a fungus of the genus CANDIDA.
An important nosocomial fungal infection with species of the genus CANDIDA, most frequently CANDIDA ALBICANS. Invasive candidiasis occurs when candidiasis goes beyond a superficial infection and manifests as CANDIDEMIA, deep tissue infection, or disseminated disease with deep organ involvement.
Candidiasis of the skin manifested as eczema-like lesions of the interdigital spaces, perleche, or chronic paronychia. (Dorland, 27th ed)
A unicellular budding fungus which is the principal pathogenic species causing CANDIDIASIS (moniliasis).
A clinical syndrome characterized by development, usually in infancy or childhood, of a chronic, often widespread candidiasis of skin, nails, and mucous membranes. It may be secondary to one of the immunodeficiency syndromes, inherited as an autosomal recessive trait, or associated with defects in cell-mediated immunity, endocrine disorders, dental stomatitis, or malignancy.
A genus of yeast-like mitosporic Saccharomycetales fungi characterized by producing yeast cells, mycelia, pseudomycelia, and blastophores. It is commonly part of the normal flora of the skin, mouth, intestinal tract, and vagina, but can cause a variety of infections, including CANDIDIASIS; ONYCHOMYCOSIS; vulvovaginal candidiasis (CANDIDIASIS, VULVOVAGINAL), and thrush (see CANDIDIASIS, ORAL). (From Dorland, 28th ed)
Substances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues.
Triazole antifungal agent that is used to treat oropharyngeal CANDIDIASIS and cryptococcal MENINGITIS in AIDS.
Immunoglobulins produced in a response to FUNGAL ANTIGENS.
Pathological processes involving the PHARYNX.
Pathological processes in the ESOPHAGUS.
Cyclic hexapeptides of proline-ornithine-threonine-proline-threonine-serine. The cyclization with a single non-peptide bond can lead them to be incorrectly called DEPSIPEPTIDES, but the echinocandins lack ester links. Antifungal activity is via inhibition of 1,3-beta-glucan synthase production of BETA-GLUCANS.
Substances of fungal origin that have antigenic activity.
The middle portion of the pharynx that lies posterior to the mouth, inferior to the SOFT PALATE, and superior to the base of the tongue and EPIGLOTTIS. It has a digestive function as food passes from the mouth into the oropharynx before entering ESOPHAGUS.
Macrolide antifungal antibiotic produced by Streptomyces nodosus obtained from soil of the Orinoco river region of Venezuela.
Polyhydric alcohols having no more than one hydroxy group attached to each carbon atom. They are formed by the reduction of the carbonyl group of a sugar to a hydroxyl group.(From Dorland, 28th ed)
Suspensions of attenuated or killed fungi administered for the prevention or treatment of infectious fungal disease.
An imidazole derivative with a broad spectrum of antimycotic activity. It inhibits biosynthesis of the sterol ergostol, an important component of fungal CELL MEMBRANES. Its action leads to increased membrane permeability and apparent disruption of enzyme systems bound to the membrane.
The presence of fungi circulating in the blood. Opportunistic fungal sepsis is seen most often in immunosuppressed patients with severe neutropenia or in postoperative patients with intravenous catheters and usually follows prolonged antibiotic therapy.
Compounds consisting of a short peptide chain conjugated with an acyl chain.
A form of invasive candidiasis where species of CANDIDA are present in the blood.
A species of MITOSPORIC FUNGI commonly found on the body surface. It causes opportunistic infections especially in immunocompromised patients.
The ability of fungi to resist or to become tolerant to chemotherapeutic agents, antifungal agents, or antibiotics. This resistance may be acquired through gene mutation.
The genital canal in the female, extending from the UTERUS to the VULVA. (Stedman, 25th ed)
Opportunistic infections found in patients who test positive for human immunodeficiency virus (HIV). The most common include PNEUMOCYSTIS PNEUMONIA, Kaposi's sarcoma, cryptosporidiosis, herpes simplex, toxoplasmosis, cryptococcosis, and infections with Mycobacterium avium complex, Microsporidium, and Cytomegalovirus.
Polysaccharides consisting of mannose units.
A species of MITOSPORIC FUNGI that is a major cause of SEPTICEMIA and disseminated CANDIDIASIS, especially in patients with LYMPHOMA; LEUKEMIA; and DIABETES MELLITUS. It is also found as part of the normal human mucocutaneous flora.
Inflammation of the vagina characterized by pain and a purulent discharge.
An imidazole antifungal agent that is used topically and by intravenous infusion.
Peptides whose amino and carboxy ends are linked together with a peptide bond forming a circular chain. Some of them are ANTI-INFECTIVE AGENTS. Some of them are biosynthesized non-ribosomally (PEPTIDE BIOSYNTHESIS, NON-RIBOSOMAL).
Lining of the ORAL CAVITY, including mucosa on the GUMS; the PALATE; the LIP; the CHEEK; floor of the mouth; and other structures. The mucosa is generally a nonkeratinized stratified squamous EPITHELIUM covering muscle, bone, or glands but can show varying degree of keratinization at specific locations.
Glucose polymers consisting of a backbone of beta(1->3)-linked beta-D-glucopyranosyl units with beta(1->6) linked side chains of various lengths. They are a major component of the CELL WALL of organisms and of soluble DIETARY FIBER.
A type of irritant dermatitis localized to the area in contact with a diaper and occurring most often as a reaction to prolonged contact with urine, feces, or retained soap or detergent.
Autoimmune diseases affecting multiple endocrine organs. Type I is characterized by childhood onset and chronic mucocutaneous candidiasis (CANDIDIASIS, CHRONIC MUCOCUTANEOUS), while type II exhibits any combination of adrenal insufficiency (ADDISON'S DISEASE), lymphocytic thyroiditis (THYROIDITIS, AUTOIMMUNE;), HYPOPARATHYROIDISM; and gonadal failure. In both types organ-specific ANTIBODIES against a variety of ENDOCRINE GLANDS have been detected. The type II syndrome differs from type I in that it is associated with HLA-A1 and B8 haplotypes, onset is usually in adulthood, and candidiasis is not present.
Pathological processes of the VAGINA.
A muscular organ in the mouth that is covered with pink tissue called mucosa, tiny bumps called papillae, and thousands of taste buds. The tongue is anchored to the mouth and is vital for chewing, swallowing, and for speech.
Infections with fungi of the genus ASPERGILLUS.
Inflammation of the VULVA and the VAGINA, characterized by discharge, burning, and PRURITUS.
Microscopic threadlike filaments in FUNGI that are filled with a layer of protoplasm. Collectively, the hyphae make up the MYCELIUM.
Enumeration by direct count of viable, isolated bacterial, archaeal, or fungal CELLS or SPORES capable of growth on solid CULTURE MEDIA. The method is used routinely by environmental microbiologists for quantifying organisms in AIR; FOOD; and WATER; by clinicians for measuring patients' microbial load; and in antimicrobial drug testing.
Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses).
Polymicrobial, nonspecific vaginitis associated with positive cultures of Gardnerella vaginalis and other anaerobic organisms and a decrease in lactobacilli. It remains unclear whether the initial pathogenic event is caused by the growth of anaerobes or a primary decrease in lactobacilli.
A triazole antifungal agent that inhibits cytochrome P-450-dependent enzymes required for ERGOSTEROL synthesis.
A human or animal whose immunologic mechanism is deficient because of an immunodeficiency disorder or other disease or as the result of the administration of immunosuppressive drugs or radiation.
Proteins found in any species of fungus.
Antibodies which elicit IMMUNOPRECIPITATION when combined with antigen.
MYCOSES of the brain, spinal cord, and meninges which may result in ENCEPHALITIS; MENINGITIS, FUNGAL; MYELITIS; BRAIN ABSCESS; and EPIDURAL ABSCESS. Certain types of fungi may produce disease in immunologically normal hosts, while others are classified as opportunistic pathogens, causing illness primarily in immunocompromised individuals (e.g., ACQUIRED IMMUNODEFICIENCY SYNDROME).
Macrolide antifungal antibiotic complex produced by Streptomyces noursei, S. aureus, and other Streptomyces species. The biologically active components of the complex are nystatin A1, A2, and A3.
Five membered rings containing a NITROGEN atom.
A decrease in the number of NEUTROPHILS found in the blood.
The study of the structure, growth, function, genetics, and reproduction of fungi, and MYCOSES.
The oval-shaped oral cavity located at the apex of the digestive tract and consisting of two parts: the vestibule and the oral cavity proper.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
A subclass of peptide hydrolases that depend on an ASPARTIC ACID residue for their activity.
An infection caused by an organism which becomes pathogenic under certain conditions, e.g., during immunosuppression.
A common gynecologic disorder characterized by an abnormal, nonbloody discharge from the genital tract.
Epithelial hyperplasia of the oral mucosa associated with Epstein-Barr virus (HERPESVIRUS 4, HUMAN) and found almost exclusively in persons with HIV infection. The lesion consists of a white patch that is often corrugated or hairy.
Inflammation of the vagina, marked by a purulent discharge. This disease is caused by the protozoan TRICHOMONAS VAGINALIS.
Broad spectrum antifungal agent used for long periods at high doses, especially in immunosuppressed patients.
A family of fused-ring hydrocarbons isolated from coal tar that act as intermediates in various chemical reactions and are used in the production of coumarone-indene resins.
Complete or severe loss of the subjective sense of taste, frequently accompanied by OLFACTION DISORDERS.
The degree of pathogenicity within a group or species of microorganisms or viruses as indicated by case fatality rates and/or the ability of the organism to invade the tissues of the host. The pathogenic capacity of an organism is determined by its VIRULENCE FACTORS.
A group of small, histidine-rich, cationic peptides in human SALIVA which are antibacterial and antifungal.
An EPITHELIUM with MUCUS-secreting cells, such as GOBLET CELLS. It forms the lining of many body cavities, such as the DIGESTIVE TRACT, the RESPIRATORY TRACT, and the reproductive tract. Mucosa, rich in blood and lymph vessels, comprises an inner epithelium, a middle layer (lamina propria) of loose CONNECTIVE TISSUE, and an outer layer (muscularis mucosae) of SMOOTH MUSCLE CELLS that separates the mucosa from submucosa.
Deoxyribonucleic acid that makes up the genetic material of fungi.
Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.
A fluorinated cytosine analog that is used as an antifungal agent.
A constitution or condition of the body which makes the tissues react in special ways to certain extrinsic stimuli and thus tends to make the individual more than usually susceptible to certain diseases.
OPPORTUNISTIC INFECTIONS with the soil fungus FUSARIUM. Typically the infection is limited to the nail plate (ONYCHOMYCOSIS). The infection can however become systemic especially in an IMMUNOCOMPROMISED HOST (e.g., NEUTROPENIA) and results in cutaneous and subcutaneous lesions, fever, KERATITIS, and pulmonary infections.
Infection with a fungus of the species CRYPTOCOCCUS NEOFORMANS.
Inflammation of the mouth due to denture irritation.
An appliance used as an artificial or prosthetic replacement for missing teeth and adjacent tissues. It does not include CROWNS; DENTAL ABUTMENTS; nor TOOTH, ARTIFICIAL.
Mentha is a genus of the mint family (LAMIACEAE). It is known for species having characteristic flavor and aroma.
A sub-subclass of endopeptidases that depend on an ASPARTIC ACID residue for their activity.
A decrease in the number of GRANULOCYTES; (BASOPHILS; EOSINOPHILS; and NEUTROPHILS).
Pulmonary diseases caused by fungal infections, usually through hematogenous spread.
Pathological processes involving the STOMACH.
Includes the spectrum of human immunodeficiency virus infections that range from asymptomatic seropositivity, thru AIDS-related complex (ARC), to acquired immunodeficiency syndrome (AIDS).
Animals not contaminated by or associated with any foreign organisms.
Hospital units providing continuing surveillance and care to acutely ill newborn infants.
The giving of drugs, chemicals, or other substances by mouth.
The return of a sign, symptom, or disease after a remission.
Essential oil extracted from Melaleuca alternifolia (tea tree). It is used as a topical antimicrobial due to the presence of terpineol.
Inorganic and organic derivatives of boric acid either B(OH)3 or, preferably H3BO3.
The number of CD4-POSITIVE T-LYMPHOCYTES per unit volume of BLOOD. Determination requires the use of a fluorescence-activated flow cytometer.
An infant whose weight at birth is less than 1000 grams (2.2 lbs), regardless of GESTATIONAL AGE.
INFLAMMATION, acute or chronic, of the ESOPHAGUS caused by BACTERIA, chemicals, or TRAUMA.
Passive agglutination tests in which antigen is adsorbed onto latex particles which then clump in the presence of antibody specific for the adsorbed antigen. (From Stedman, 26th ed)
An infant during the first month after birth.
Substances, usually of biological origin, that cause cells or other organic particles to aggregate and stick to each other. They include those ANTIBODIES which cause aggregation or agglutination of particulate or insoluble ANTIGENS.
Diseases in any segment of the GASTROINTESTINAL TRACT from ESOPHAGUS to RECTUM.
The ability of microorganisms, especially bacteria, to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).
Deliberate prevention or diminution of the host's immune response. It may be nonspecific as in the administration of immunosuppressive agents (drugs or radiation) or by lymphocyte depletion or may be specific as in desensitization or the simultaneous administration of antigen and immunosuppressive drugs.
Procedures for identifying types and strains of fungi.
The washing of the VAGINA cavity or surface with a solution. Agents or drugs can be added to the irrigation solution.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Meningitis caused by fungal agents which may occur as OPPORTUNISTIC INFECTIONS or arise in immunocompetent hosts.
A naturally occurring glucocorticoid. It has been used in replacement therapy for adrenal insufficiency and as an anti-inflammatory agent. Cortisone itself is inactive. It is converted in the liver to the active metabolite HYDROCORTISONE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p726)
A plant genus of the family MYRTACEAE. M. alternifolia foliage is a source of TEA TREE OIL. The common name of tea tree also refers to LEPTOSPERMUM or KUNZEA. M. vindifolia is a source of niaouli oil. M. cajuputi and M. leucadendra are sources of cajuput oil.
The clear, viscous fluid secreted by the SALIVARY GLANDS and mucous glands of the mouth. It contains MUCINS, water, organic salts, and ptylin.
A plant genus of the family FABACEAE. Many species of this genus, including the medicinal C. senna and C. angustifolia, have been reclassified into the Senna genus (SENNA PLANT) and some to CHAMAECRISTA.
A plant species of the genus CINNAMOMUM that contains CINNAMATES and has been used in traditional Chinese medicine (DRUGS, CHINESE HERBAL).
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
The muscular membranous segment between the PHARYNX and the STOMACH in the UPPER GASTROINTESTINAL TRACT.
A plant genus of the family GERANIACEAE. Geranium is also used as a common name for PELARGONIUM.
Immunoelectrophoresis in which immunoprecipitation occurs when antigen at the cathode is caused to migrate in an electric field through a suitable medium of diffusion against a stream of antibody migrating from the anode as a result of endosmotic flow.
The ability of lymphoid cells to mount a humoral or cellular immune response when challenged by antigen.

Incidence and predictors of invasive candidiasis associated with candidaemia in children. (1/75)

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High ferritin levels are associated with hepatosplenic candidiasis in hematopoietic stem cell transplant candidates. (2/75)

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Prediction of the clinical outcome in invasive candidiasis patients based on molecular fingerprints of five anti-Candida antibodies in serum. (3/75)

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Endosomal and AP-3-dependent vacuolar trafficking routes make additive contributions to Candida albicans hyphal growth and pathogenesis. (4/75)

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Prospective survey of (1-->3)-beta-D-glucan and its relationship to invasive candidiasis in the surgical intensive care unit setting. (5/75)

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Organ-specific innate immune responses in a mouse model of invasive candidiasis. (6/75)

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PCR diagnosis of invasive candidiasis: systematic review and meta-analysis. (7/75)

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The use of mannan antigen and anti-mannan antibodies in the diagnosis of invasive candidiasis: recommendations from the Third European Conference on Infections in Leukemia. (8/75)

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Recent changes in the aetiology and epidemiology of invasive candidiasis have serious implications for current and future diagnosis, treatment and prognosis. The aim of the current review was to discuss the epidemiology of invasive candidiasis, the distribution of Candida species in different regions of the world, the medical concerns of the changing aetiology and the emergence of antifungal resistance. Overall burden of invasive candidiasis remains high, especially in vulnerable persons, such as the elderly, immunosuppressed or debilitated patients. Moreover, there is a progressive shift in the aetiology of invasive candidiasis from Candida albicans to other species of Candida, probably related to the increased use of azole drugs with a clear trend towards increased antifungal resistance. Finally, the emergence and rise of multiresistant species, such as Candida auris or Candida glabrata, is a major threat making necessary invasive candidiasis worldwide surveillances. These changes have serious ...
Invasive candidiasis differs greatly between children and neonates. We aimed to investigate the different therapeutic approaches and their effects on treatment outcomes of these two groups. Episodes of neonatal invasive candidiasis were compared with non-neonatal pediatric episodes during a 12-year cohort study. Clinical isolates were documented by matrix-assisted laser desorption/ionization-time of flight mass spectrometry and DNA sequencing, and antifungal susceptibility testing was performed. A total of 342 episodes of invasive candidiasis (113 neonatal and 229 non-neonatal pediatric episodes) in 281 pediatric patients (96 neonates and 185 children) were identified. Candida albicans was the most common pathogen causing invasive candidiasis in neonates and children (47.8% vs. 44.1%). The antifungal susceptibility profiles were not significantly different between neonates and children. More neonates received amphotericin B as therapy, whereas more children received fluconazole or caspofungin. Compared
Although the diagnostic performance for all tests were modest in regards to the detection of invasive candidiasis in patients in a high-risk intensive care unit (ICU), the combination of the new test T2Candida and blood culture seemed to have the best performance, according to a study published in Open Forum Infectious Diseases.. Blood culture is the gold standard test for invasive candidiasis, comprising candidemia and deep-seated candidiasis, but the sensitivity of this test is low. The average time to blood culture positivity is approximately 2 days, and some studies have associated a 2-day antifungal therapy delay with a more than doubled mortality rate. There is, therefore, a need for rapid diagnostic testing in invasive candidiasis.. ...
TY - JOUR. T1 - Anidulafungin compared with fluconazole in severely ill patients with candidemia and other forms of invasive candidiasis. T2 - Support for the 2009 IDSA treatment guidelines for candidiasis. AU - Kett, Daniel H.. AU - Shorr, Andrew F.. AU - Reboli, Annette C.. AU - Reisman, Arlene L.. AU - Biswas, Pinaki. AU - Schlamm, Haran T.. PY - 2011/10/25. Y1 - 2011/10/25. N2 - Introduction: During the past decade, the incidence of Candida infections in hospitalized patients has increased, with fluconazole being the most commonly prescribed systemic antifungal agent for these infections. However, the 2009 Infectious Diseases Society of America (IDSA) candidiasis guidelines recommend an echinocandin for the treatment of candidemia/invasive candidiasis in patients who are considered to be moderately severe or severely ill. To validate these guidelines, clinical trial data were reviewed.Methods: A secondary analysis of data from a previously published prospective, randomized, double-blind ...
The study presented here was performed in order to create a rule that identifies subjects at high risk for invasive candidiasis in the intensive care setting. Retrospective review and statistical modelling were carried out on 2,890 patients who stayed at least 4 days in nine hospitals in the USA and Brazil; the overall incidence of invasive candidiasis in this group was 3% (88 cases).
Invasive candidiasis is a major nosocomial fungal disease in the United States associated with high rates of illness and death. We analyzed inpatient hospitalization records from the Healthcare Cost and Utilization Project to estimate incidence of invasive candidiasis-associated hospitalizations in the United States. We extracted data for 33 states for 2002-2012 by using codes from the International Classification of Diseases, 9th Revision, Clinical Modification, for invasive candidiasis; we excluded neonatal cases. The overall age-adjusted average annual rate was 5.3 hospitalizations/100,000 population. Highest risk was for adults >65 years of age, particularly men. Median length of hospitalization was 21 days; 22% of patients died during hospitalization. Median unadjusted associated cost for inpatient care was $46,684. Age-adjusted annual rates decreased during 2005-2012 for men (annual change -3.9%) and women (annual change -4.5%) and across nearly all age groups. We report a high mortality
The title of the study will be Attributable mortality and Costs of Invasive Candida Infections in European hospitals: a prospective case-control study, and the study as well as the working group will be lead by PD Martin Hoenigl and Prof. Oliver Cornely. The case-control study will focus on evaluating attributable mortality and costs as well as diagnostic and therapeutic approaches (including prolonged hospital stay for completion of parenteral antifungal treatment) of nosocomial IC infections in Europe. As a secondary objective we will evaluate antifungal resistance among Candida spp. causing invasive diseases across Europe. In addition, the case control design will allow for implementation of health economic analyses on the incremental costs associated with IC infections ...
Pfizer Limited today welcomes the Scottish Medicines Consortium (SMC) advice, which recommends Ecalta (anidulafungin), a new antifungal medicine for the treatment of invasive candidiasis in NHS Scotland.1 Following a re-submission, the SMCs decision to recommend anidulafungin comes after results of the cost-minimisation analysis which indicated that anidulafungin would be preferred to both caspofungin and liposomal amphotericin B, with savings of 772 and 2,375 respectively, as a
Candidaemia and other forms of invasive candidiasis (C/IC) in the intensive care unit are challenging conditions that are associated with high rates of mortality. New guidelines from the European Society for Clinical Microbiology and Infectious Diseases strongly recommend echinocandins for the first-line treatment of C/IC. Here, a cost-effectiveness model was developed from the United Kingdom perspective to examine the costs and outcomes of antifungal treatment for C/IC based on the European Society for Clinical Microbiology and Infectious Diseases guidelines. Costs and treatment outcomes with the echinocandin anidulafungin were compared with those for caspofungin, micafungin and fluconazole. The model included non-neutropenic patients aged ≥16 years with confirmed C/IC who were receiving intravenous first-line treatment. Patients were categorised as either a clinical success or failure (patients with persistent/breakthrough infection); successfully treated patients switched to oral therapy, while
28. Empiric antifungal therapy should be considered in critically ill patients with risk factors for invasive candidiasis and no other known cause of fever and should be based on clinical assessment of risk factors, surrogate markers for invasive candidiasis, and/or culture data from nonsterile sites (strong recommendation; moderate-quality evidence). Empiric antifungal therapy should be started as soon as possible in patients who have the above risk factors and who have clinical signs of septic shock (strong recommendation; moderate-quality evidence). ...
A Study of Caspofungin Acetate (MK0991) for the Treatment of Esophageal Candidiasis or Invasive Candidiasis in Chinese Adults (MK-0991-066 ...
A QIDP designation, granted under the U.S. GAIN Act, provides priority review and a five-year extension of market exclusivity, should the product be approved in the United States. Isavuconazole was previously granted QIDP designation for the treatment of invasive aspergillosis and invasive mucormycosis (also known as zygomycosis), which are severe mold infections. In addition, isavuconazole has FDA fast-track status and received U.S. and European Union orphan drug designations for invasive aspergillosis and mucormycosis.. Prof. Achim Kaufhold, Basileas Chief Medical Officer, commented: Invasive candidiasis is a nosocomial infection associated with high mortality, frequently occurring in critically ill patients, such as cancer patients undergoing chemotherapy, organ transplantation, and invasive surgical procedures. Moreover, the incidence of Candida infections has been increasing over past decades. He added: We are very pleased that the FDA has granted this third QIDP designation to ...
Epidemiology and risk factors for invasive candidiasis Nur Yapar Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Dokuz Eylül University, İzmir, Turkey Abstract: The number of immunosuppressive patients has increased significantly in recent years. These patients are at risk for opportunistic infections, especially fungal infections. Candidiasis is one of the most frequent fungal infections determined in these immunosuppressive patients and its epidemiology has changed over the last two decades. Recently, new antifungal agents and new therapy strategies such as antifungal prophylaxis, secondary prophylaxis, and preemptive therapy have come into use. These changes resulted in the alteration of Candida species causing invasive infections. The incidence of Candida albicans was decreased in many countries, especially among patients with immunosuppressive disorders, while the incidence of species other than C. albicans was increased. In this review, incidence, risk
Viscoli, C. Recent Advances in the Management of Invasive Candidiasis. Drugs 69, 1-3 (2009). https://doi.org/10.2165/11315490-000000000-00000. Download ...
Although prompt initiation of appropriate antifungal therapy is essential for the control of invasive Candida infections and an improvement of prognosis, early diagnosis of invasive candidiasis remains a challenge and criteria for starting empirical antifungal therapy in ICU patients are poorly defined. Some scoring systems, such as the Candida score could help physicians to differentiate patients who could benefit from early antifungal treatment from those for whom invasive candidiasis is highly improbable. This study evaluated the performance of this score in a cohort of critically ill patients. A prospective, observational, multicenter, cohort study was conducted from January 2010 to March 2011 in five intensive care units in Nord-Pas de Calais, an area from North of France. All patients exhibiting, on ICU admission or during their ICU stay, a hospital-acquired severe sepsis or septic shock could be included in this study. The data collected included patient characteristics on ICU admission and at
This study will create an international multi-center cohort of children with new clinical concern for infection while in the hospital. Sites used are part of the International Pediatric Fungal Network (ipfn.org). The study plans to prospectively enroll pediatric patients at high-risk of developing invasive candidiasis over a four year period. The study duration per subject will be up to 14 days for blood collection and 30 days for data collection from the medical record.. For the first aim, this study will assemble a prospective cohort of pediatric patients at high-risk for developing invasive candidiasis. Blood samples for biomarker testing will be obtained within 24-hours of a patient having a clinical indication for blood culture attainment. To accomplish the second aim, additional blood sampling will be performed in the sub-set of patients that are found to have invasive candidiasis. For the third aim, remnant blood samples following biomarker testing from all consenting participants will be ...
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Even the most symptomatic cases of candida are treatable! This otherwise normal fungal resident of our GI tract, when it becomes invasive, leads to a whole host of symptoms, including bloating, gas, constipation and other digestive issues, brain fog, drunken-like behavior in children, food sensitivities and leaky gut. Hear Dr. Kurt Woeller, DO explore the root causes of candidiasis, its connection to autism, how to test for it and treatments including probiotics, diet changes, prescription and herbal medications. Lindsey Parsons, your host, helps clients solve gut issues and reverse autoimmune disease naturally. Shes a Certified Health Coach at in Tucson, Arizona. She coaches clients locally and nationwide. You can also follow Lindsey on , , or or reach her via email at [email protected] to set up a free 30-minute .
Comment.Studies assessing patients with candidemia versus healthy controls showed that PCR of whole-blood samples targeting panfungal genes has 100% sensitivity and specificity. When patients with candidemia constituted the case definition and patients with sepsis at risk for IC without candidemia constituted the control group, the sensitivity was 100% in 31/49 studies and the pooled (HSROC) sensitivity was 0.95 (95% confidence interval, 0.88 to 0.98). As expected, sensitivity decreased as the reference standard became less stringent, from proven through probable to possible IC. In the analysis where patients with cases had proven/probable or possible IC and other patients at risk for IC were controls, the pooled (HSROC) sensitivity was 0.73 (0.58 to 0.83). The pooled specificity was above 90% in all analyses. In studies conducted after 2000, positive likelihood ratios were higher than those in older studies, ranging from 14 to 24 in the different analyses, and the negative likelihood ratio for ...
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Systemic fungal infections are increasingly common, especially in immune compromised patients. While new antifungal drugs have been developed, there is still a...
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Steinbach WJ, Roilides E, Berman D, Hoffman JA, Groll AH, Bin-Hussain I, Palazzi DL, Castagnola E, Halasa N, Velegraki A, Dvorak CC, Charkabarti A, Sung L, Danziger-Isakov L, Lachenauer C, Arrieta A, Knapp K, Abzug MJ, Ziebold C, Lehrnbecher T, Klingspor L, Warris A, Leckerman K, Martling T, Walsh TJ, Benjamin DK, Zaoutis TE. Results from a prospective, international, epidemiologic study of invasive candidiasis in children and neonates. Pediatr Infect Dis J. 2012 Dec; 31(12):1252-7 ...
Individuals at risk for invasive candidiasis include low birth weight babies, people recovering from surgery, people admitted to an intensive care units
Candida albicans dimorphism is a crucial virulence factor during invasive candidiasis infections, which claim the lives of nearly one-half of those afflicted. It has long been believed that filaments drive tissue invasion and yeast mediates bloodstream dissemination, but observation of these activities during infection has been prevented by technical limitations.... ...
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From millions of real job salary data. 1 Internist/infectious Diseases Physician salary data. Average Internist/infectious Diseases Physician salary is $190,000 Detailed Internist/infectious Diseases Physician starting salary, median salary, pay scale, bonus data report
By Chen, Hua Suda, Katie J; Turpin, Robin S; Pai, Manjunath P; Et al Key words: Candidiasis - Cost-effectiveness analysis - Fluconazole - Pharmacoeconomics ABSTRACT Background: High-dose fluconazole is an alternative for patients with candidemia caused by Candida glabrata or other Candida species with decreased fluconazole susceptibility. However, empiric high- dose fluconazole is not currently recommended and may result in higher drug costs and toxicity. Objective: To determine the cost-effectiveness of using empiric high-dose fluconazole in intensive care unit (ICU) with suspected invasive candidiasis. Design: Decision analytic model. Target population: ICU patients with suspected invasive candidiasis. Time horizon: Lifetime. Perspective: Societal. Interventions: Low-dose fluconazole (loading dose of 800 mg followed by 400 mg daily) vs. high-dose fluconazole (loading dose of 1600 mg followed by 800 mg daily). Generic fluconazole costs were used for the analysis. Outcome measures: Incremental ...
article{c7437ca5-8401-4db0-b1c9-267013d9baa1, abstract = {In 2 prospective studies, we previously reported on the early and accurate diagnosis of invasive candidiasis by determining the D-arabinitol/L-arabinitol (DA/LA) ratio in urine in neutropenic children with cancer at the paediatric oncology unit (POU) and in premature infants at the neonatal intensive care unit (NICU) at our hospital. In this retrospective study at the same units, we report how the DA/LA assay was implemented in clinical practice immediately after the prospective study periods. We found that, in the POU, the recommendation of regularly monitoring urine DA/LA ratios in patients at risk and considering antifungal therapy in the case of elevated ratios had been followed. A significant decrease in the incidence of culture positive invasive candidiasis may have been attributed to the introduction of the DA/LA assay. At the NICU, where the DA/LA assay was recommended only as an adjunct to other diagnostic tools, morbidity in ...
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Introduction. Invasive infections caused by Candida spp. in critically ill patients may significantly worsen their prognosis, so it is of great importance to establish an early detection and a suitable therapeutic strategy. The objective of this study was to define the differential role of echinocandins in treating certain critical patient profiles.Methodology. A scientific committee of 9 experts in infectious diseases, critical care, microbiology, and hospital pharmacy reviewed the existing evidence on the treatment of candidemia and invasive candidiasis in critically ill patients. After that, a questionnaire with 35 items was elaborated to be agreed by 26 specialists in the aforementioned disciplines using a modified Delphi method.Results. After two rounds of evaluation, a consensus was reached in terms of agreement in 66% of the items. Some of the consensuses achieved included: it is not necessary to adjust the dose of echinocandins during renal replacement therapy; the echinocandins are the ...
The ECIL-5 meeting was held in September 2013 and involved 57 experts from 21 countries, including 3 non-European countries. Slides of the conclusions of the ECIL-5 were made available on the websites of the EORTC, EBMT, ELN, and ICHS. The ECIL-6 meeting was held in September 2015 with the presence of 55 experts from 24 countries, including 4 non-European countries (see list of collaborators at the end of this Review).. At both the ECIL-5 and the ECIL-6 meetings, the antifungal therapy working group made a search for new publications regarding treatment of invasive candidiasis, aspergillosis and mucormycosis. The group was divided into three subgroups, each being responsible for one of each fungal infection type. The literature search was performed in Pubmed and Cochrane databases. Abstracts presented at major congresses during the previous two years were also retrieved and integrated into the ECIL recommendation. All recommendations referring to an abstract, however, were classified as ...
As the COVID-19 pandemic spread over the world, taking over our collective global consciousness, I couldnt help but be reminded of the earliest days of my career as an infectious diseases physician. My fellowship began during another viral pandemic: H1N1 influenza. Every night brought calls to the bedsides of shockingly young patients who were profoundly sick in the ICU. The similarities between 2009 and the current COVID-19 pandemic, however, end there.. Despite being a new strain of influenza that was particularly deadly for young people, H1N1 quickly revealed its secrets to us. We learned early how it spread, how to treat it, and, eventually, how to develop a vaccine for it. The current novel coronavirus however, has offered no such early victories. Much of the spring passed in a blur as healthcare workers across the country struggled to cope with the sick flooding into our hospitals.. The pandemic made it impossible to deny the inequities in our society, with historically marginalized and ...
Dr. Jeffrey Lederman, MD of New Rochelle, NY patient reviews, appointments, phone number and quality report. Compare Dr. Lederman to other nearby Infectious Disease Physicians in New York.
Dr. Christopher Cirino, DO of Portland, OR patient reviews, appointments, phone number and quality report. Compare Dr. Cirino to other nearby Infectious Disease Physicians in Oregon.
TY - JOUR. T1 - MSG-10. T2 - a Phase 2 study of oral ibrexafungerp (SCY-078) following initial echinocandin therapy in non-neutropenic patients with invasive candidiasis. AU - Mycoses Study Group AU - Spec, Andrej. AU - Pullman, John. AU - Thompson, George Richard. AU - Powderly, William G.. AU - Tobin, Ellis H.. AU - Vazquez, Jose. AU - Wring, Stephen A.. AU - Angulo, David. AU - Helou, Silvia. AU - Pappas, Peter G.. PY - 2019/10/1. Y1 - 2019/10/1. N2 - OBJECTIVES: To evaluate the safety and efficacy of two dosing regimens of oral ibrexafungerp (formerly SCY-078), a novel orally bioavailable β-glucan synthase inhibitor, in subjects with invasive candidiasis versus the standard of care (SOC) and to identify the dose to achieve target exposure (15.4 μM·h) in ,80% of the intended population. METHODS: In a multinational, open-label study, patients with documented invasive candidiasis were randomized to receive step-down therapy to one of three treatment arms: two dosing regimens of novel oral ...
Acute disseminated candidiasis, or invasive candidiasis, is a fungal infection of Candida spp. It usually presents as candidemia and progresses to several viscera (ie, liver, kidney, spleen, eyes, brain, and heart). Candida spp are among the most common causes of nosocomial bloodstream infections typically introduced from the gastrointestinal tract or from venous catheters.1 Clinical manifestations of candidiasis can be nonspecific but may include unresolved fever and may progress to sepsis. Definitive diagnosis requires histopathologic confirmation, but presumptive diagnosis is used frequently in high-risk immunosuppressed or neutropenic patients. Pharmacologic intervention is required with a confirmed positive culture, and catheter removal is recommended for suspected infections.2 The most common pathogen for invasive candidiasis is C albicans (41%-65%); however, non-albicans Candida spp resistant to conventional treatments have emerged as prevalent causes of candidiasis, including C ...
Echinocandins, such as anidulafungin are first line treatment for candidemia or invasive candidiasis in critically ill patients. There is conflicting data on the pharmacokinetic properties of anidulafungin in ICU patients. Adult ICU patients (from 3 hospitals) receiving anidulafungin for suspected or proven fungal infections were included. Patient were considered evaluable ... read more when a pharmacokinetic curve on day 3 could be completed. 23 out of 36 patients (7 female, 16 male) were evaluable. Median (range) age and bodyweight were 66 (28-88) yr and 76 (50-115) kg. Pharmacokinetic sampling on day 3 (n=23) resulted in a median anidulafungin AUC0-24h of 72.1 (IQR 61.3-94.0) mg*h*L(-1), a median C24 of 2.2 (IQR 1.9-2.9) mg/L, a median Cmax of 5.3 (IQR 4.1-6.0) mg/L, a median Vd of 46.0 (IQR 32.2-60.2) L and a median CL of 1.4 (IQR 1.1-1.6) L*h-1. Pharmacokinetic sampling on day 7 (n=13) resulted in a median AUC0-24h of 82.7 (IQR 73.0 - 129.5) mg*h*L(-1), a median Cmin of 2.8 (IQR 2.2 - 4.2) ...
The annual incidence of candidemia in Iceland increased from 1.4 cases/100,000 inhabitants/year during 1980-1984 to 5.3 cases/100,000 inhabitants/year during 2000-2006 (p,0.001), with the greatest increase in incidence occurring among infants ,1 year of age and the elderly (age, ,60 years). C. albicans was the predominant species responsible (61.6%). The national import of fluconazole increased approximately 5.5-fold from 1991 through 2006, but increased resistance to this agent was not observed. Most cases occurred in intensive care units (35.8%) and surgical wards (30.1%). In multivariate analysis, prompt removal of central venous catheters (odds ratio [OR], for death, 0.22) and septic shock (OR for death, 8.01) were the strongest independent predictors of outcome. PCR fingerprinting of Candida BSIs (n=219) from 94.4% of cases during 1991-2006 revealed temporo-spatial associations between 18.7-39.9% of all infections, suggestive of nosocomial clustering. When the virulence of C. albicans and ...
Background Matrix-assisted laser desorption ionisation time of flight mass spectrometry (MALDI TOF-MS) allows the identification of most bacteria and an increasing number of fungi. The potential for the highest clinical benefit of such methods would be in severe acute infections that require prompt treatment adapted to the infecting species. Our objective was to determine whether yeasts could be identified directly from a positive blood culture, avoiding the 1-3 days subculture step currently required before any therapeutic adjustments can be made. Methodology/Principal Findings Using human blood spiked with Candida albicans to simulate blood cultures, we optimized protocols to obtain MALDI TOF-MS fingerprints where signals from blood proteins are reduced. Simulated cultures elaborated using a set of 12 strains belonging to 6 different species were then tested. Quantifiable spectral differences in the 5000-7400 Da mass range allowed to discriminate between these species and to build a reference
Full Text (subscription or payment may be required). Flu Vaccine Expected to Protect Against Most U.S. H3N2 Viruses. FRIDAY, Dec. 15, 2017 (HealthDay News) - A novel bioinformatics approach can predict vaccine effectiveness for the influenza season, and indicates that the current vaccines are likely to be effective against H3N2 flu viruses in the U.S. 2017/2018 flu season, according to research published online Nov. 29 in F1000 Research.. Abstract/Full Text. Functional Limitations Ongoing With Congenital Zika. FRIDAY, Dec. 15, 2017 (HealthDay News) - Severe functional limitations are reported among children with microcephaly and laboratory evidence of Zika virus infection in infancy, according to research published in the Dec. 15 issue of the U.S. Centers for Disease Control and Preventions Morbidity and Mortality Weekly Report.. Abstract/Full Text. Making Insurers Participate in Marketplace Could Cut Volatility. THURSDAY, Dec. 14, 2017 (HealthDay News) - Requiring insurers that participate in ...
Swine flu expert chats liveShould I eat pork? Should I avoid public places? Is this scratchy throat a sign of the swine flu?These and other questions related to contracting, avoiding and pinpointing
3 Indications Requested in the NDA Treatment of invasive aspergillosis Empiric antifungal therapy of febrile neutropenic patients Treatment of: -candida esophagitis -serious candida infections -serious fungal infections due to Fusarium and Scedosporium spp. -serious fungal infections in patients refractory or intolerant to other therapy
Read ratings and reviews for Dr. Thomas F Orman who has 43 years of experience as a Cardiovascular Disease Physician in Terre Haute, IN.
Dr. Padubidri S Chandrashekar, MD, rated 5/5 by patients. 10 reviews, Phone number & practice locations, Cardiovascular Disease Physician in Whitesburg, KY.
TY - JOUR. T1 - Impact of Antimicrobial Prophylaxis for Severe Acute Pancreatitis on the Development of Invasive Candidiasis. T2 - A Large Retrospective Multicenter Cohort Study. AU - Horibe, Masayasu. AU - Sanui, Masamitsu. AU - Sasaki, Mitsuhito. AU - Honda, Hitoshi. AU - Ogura, Yuki. AU - Namiki, Shin. AU - Sawano, Hirotaka. AU - Goto, Takashi. AU - Ikeura, Tsukasa. AU - Takeda, Tsuyoshi. AU - Oda, Takuya. AU - Yasuda, Hideto. AU - Miyazaki, Dai. AU - Hirose, Kaoru. AU - Kitamura, Katsuya. AU - Chiba, Nobutaka. AU - Ozaki, Tetsu. AU - Yamashita, Takahiro. AU - Koinuma, Toshitaka. AU - Oshima, Taku. AU - Yamamoto, Tomonori. AU - Hirota, Morihisa. AU - Yamamoto, Satoshi. AU - Oe, Kyoji. AU - Ito, Tetsuya. AU - Masuda, Yukiko. AU - Saito, Nobuyuki. AU - Iwasaki, Eisuke. AU - Kanai, Takanori. AU - Mayumi, Toshihiko. N1 - Publisher Copyright: © 2019 Wolters Kluwer Health, Inc. All rights reserved. Copyright: Copyright 2019 Elsevier B.V., All rights reserved.. PY - 2019/4/1. Y1 - 2019/4/1. N2 - ...
The House Energy and Commerce Committees Subcommittee on Health is considering reauthorization of the Project BioShield Act, legislation passed in 2004 that is designed to spur companies into making countermeasures against a bioterrorist attack. However, in testimony before the subcommittee today, Martin J. Blaser, MD, president of the Infectious Diseases Society of America (IDSA), emphasized a different threat, one that infectious diseases physicians witness every day: the burden of antimicrobial-resistant infections such as methicillin-resistant Staphylococcus aureus (MRSA). Antimicrobial resistant infections have created a silent epidemic in communities and hospitals across the country, Blaser said, crippling and killing a growing number of otherwise-healthy people and driving up healthcare costs. To make matters worse, the IDSA says, the pharmaceutical industry has lost interest in developing new antibiotics to fight these infections because they are not as profitable as drugs for ...
TY - JOUR. T1 - Reply to Van Daele et al., Fluconazole Underexposure in Critically Ill Patients. T2 - a Matter of Using the Right Targets?. AU - Märtson, A G. AU - Boonstra, J M. AU - Sandaradura, I. AU - Kosterink, J G. AU - van der Werf, T S. AU - Marriott, D J E. AU - Zijlstra, J G. AU - Touw, D J. AU - Alffenaar, J W C. N1 - Copyright © 2021 American Society for Microbiology.. PY - 2021/5. Y1 - 2021/5. N2 - We thank Van Daele et al (1) for their interest in our study investigating the pharmacokinetics in critically ill patients with aim to optimize fluconazole dosing for the prevention and treatment of invasive candida infections (2).….. AB - We thank Van Daele et al (1) for their interest in our study investigating the pharmacokinetics in critically ill patients with aim to optimize fluconazole dosing for the prevention and treatment of invasive candida infections (2).….. UR - http://www.scopus.com/inward/record.url?scp=85106667811&partnerID=8YFLogxK. U2 - ...
Invasive mycoses are life-threatening opportunistic infections and have emerged as a major cause of morbidity and mortality in critically ill patients. This review focuses on recent advances in our understanding of the epidemiology, diagnosis and management of invasive candidiasis, which is the predominant fungal infection in the intensive care unit setting. Candida spp. are the fourth most common cause of bloodstream infections in the USA, but they are a much less common cause of bloodstream infections in Europe. About one-third of episodes of candidaemia occur in the intensive care unit. Until recently, Candida albicans was by far the predominant species, causing up to two-thirds of all cases of invasive candidiasis. However, a shift toward non-albicans Candida spp., such as C. glabrata and C. krusei, with reduced susceptibility to commonly used antifungal agents, was recently observed. Unfortunately, risk factors and clinical manifestations of candidiasis are not specific, and conventional culture
The T2Dx Instrument, the T2Bacteria and T2Candida Panels have received marketing authorization from the U.S. Food and Drug Administration. All other T2 Biosystems products are considered investigational and for research use only.. T2 Biosystems®, T2MR®, T2Bacteria®, T2Candida®, and T2Dx® are registered trademarks of T2 Biosystems, Inc. T2Biosystems and the T2 Biosystems, Inc. logo design are registered trademarks or trademarks of T2Biosystems, Inc. All software and documentation is subject to T2 Biosystems, Inc. copyrights. All rights reserved. T2Direct Diagnostics™, T2HemoStat™, and T2Plex™ are trademarks of T2 Biosystems, Inc.. © 2019 T2 Biosystems, Inc. ...
Review question. We reviewed the evidence from randomized controlled trials for the benefits and safety of all prescription medicines used to treat critically ill adult patients with delirium in the intensive care units (ICUs) of hospitals.. Background Delirium is commonly associated with surgery, infection, or critical illness. It is experienced as new-onset, generally short-term inability to think clearly. Patients with delirium shift between periods of clear thinking and periods of agitation and/or great sleepiness and confusion. Lack of sleep, pain, a noisy environment, physical restraint, and the use of sedatives and strong analgesics are some of the contributing factors. Delirium affects both immediate and longer-term health outcomes of critically ill patients as it can increase the length of time a breathing machine is required, time spent in the ICU and in hospital, and the chance of functional weakening and death. The odds of a poor outcome with delirium are increased with frail ...
TY - JOUR. T1 - Diagnostic value of procalcitonin and presepsin for sepsis in critically ill adult patients. T2 - A systematic review and meta-analysis. AU - Kondo, Yutaka. AU - Umemura, Yutaka. AU - Hayashida, Kei. AU - Hara, Yoshitaka. AU - Aihara, Morio. AU - Yamakawa, Kazuma. PY - 2019/4/15. Y1 - 2019/4/15. N2 - Background: Early and accurate diagnosis of sepsis is challenging. Although procalcitonin and presepsin have been identified as potential biomarkers to differentiate between sepsis and other non-infectious causes of systemic inflammation, the diagnostic accuracy of these biomarkers remains controversial. Herein, we performed a comprehensive meta-analysis to assess the overall diagnostic value of procalcitonin and presepsin for the diagnosis of sepsis. Methods: We searched three electronic databases (MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials) for relevant studies. Two authors independently screened articles on the basis of inclusion and exclusion ...
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BACKGROUND: Most of the studies about invasive Candida infections in cancer patients have focused on haematological patients. The aim of this study was to provide information about risk factors for candidaemia in patients with solid tumours. METHODS: Retrospective cohort study. During a 9-year period (1995-2003) we reviewed all cases of candidaemia that affected cancer patients in Santa Casa Complexo Hospitalar, Brazil. RESULTS: During the period of study, 210 patients had the diagnosis of candidaemia in our medical centre, and 83 of these patients had cancer (39.5%). The majority of patients with cancer had solid tumours (77.1%), mostly in the alimentary tract. Most of solid cancers were non-metastatic (71.9%). Major diagnoses in patients with haematological neoplasia were acute leukaemia (n = 13), high grade non-Hodgkin lymphoma (n = 5) and Hodgkins disease (n = 1). Non-Candida albicans species caused 57.8% of the episodes of candidaemia in patients with cancer, mainly in patients with ...
Abstract Introduction: The prompt initiation of appropriate antifungal therapy is essential in controlling invasive candidiasis and improving the prognosis in critical patients undergoing treatment in the Intensive Care Unit. Candida Score can assess patients at risk of candidiasis and is expected to assist clinicians in starting antifungal therapy in patients suspected Candidiasis. The purpose of this study was to determine the pattern of antifungal administration in critically ill patients with candidiasis in the Intensive Care Unit at Sanglah General Hospital. Patients and Methods: The design of this study is a cross-sectional descriptive study involving critically ill patients who were under treatment in Intensive Care Unit of Sanglah General Hospital from Januari to June 2019. The patients included in this study were patients who were ≥ 18 years old and under treatment in ICU for at least 7 days. Results: There are 64 patients undergoing treatment in the Intensive Care Unit. From 64 patients,
Washington, DC - Trust for Americas Health (TFAH) and The Infectious Diseases Society of America (IDSA) applaud the Obama administration and the Food and Drug Administration (FDA) for adopting a new approach for the use of antimicrobial drugs in animal agriculture. These actions demonstrate a clear commitment to sound and science-based policies that will protect the health of every American.. In a letter to Melody Barnes, President Obamas assistant for domestic policy, IDSA and TFAH expressed their strong support for the administrations new public health approach to antimicrobial use in animals, which calls for phasing out the use of antimicrobial drugs for growth promotion and feed efficiency. The new approach also requires that all other uses of these drugs be carried out under the supervision of a veterinarian and within the boundaries of a valid veterinarian-client-patient relationship-thereby ending over-the-counter sales of tons of antimicrobial drugs annually.. We recognize that ...
By Richard R. Watkins, MD, MS, FACP, FIDSA Professor of Internal Medicine, Northeast Ohio Medical University; Division of Infectious Diseases, Cleveland Clinic Akron General, Akron, OH Dr. Watkins reports no financial relationships relevant to this field of study. SYNOPSIS: In a large, randomized, double-blind, multicenter clinical trial, researchers found that isavuconazole did not meet the primary endpoint of noninferiority compared to caspofungin for candidemia and invasive candidiasis. SOURCE: Kullberg BJ, Viscoli C, Pappas PG, et al. Isavuconazole versus caspofungin in the treatment of candidemia and . . .
Anidulafungin is a semi-synthetic lipopeptide synthesized from a fermentation product of Aspergillus nidulans. Anidulafungin is an echinocandin, a class of antifungal drugs that inhibits the synthesis of 1,3-β-D-glucan, an essential component of fungal cell walls. Anidulafungin is active in vitro against many Candida, as well as some Aspergillus. Like other echinocandins, anidulafungin is not active against Cryptococcus neoformans, Trichosporon, Fusarium, or zygomycetes ...

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