Candidemia: A form of invasive candidiasis where species of CANDIDA are present in the blood.Fungemia: The presence of fungi circulating in the blood. Opportunistic fungal sepsis is seen most often in immunosuppressed patients with severe neutropenia or in postoperative patients with intravenous catheters and usually follows prolonged antibiotic therapy.Candidiasis: Infection with a fungus of the genus CANDIDA. It is usually a superficial infection of the moist areas of the body and is generally caused by CANDIDA ALBICANS. (Dorland, 27th ed)Candida: A genus of yeast-like mitosporic Saccharomycetales fungi characterized by producing yeast cells, mycelia, pseudomycelia, and blastophores. It is commonly part of the normal flora of the skin, mouth, intestinal tract, and vagina, but can cause a variety of infections, including CANDIDIASIS; ONYCHOMYCOSIS; vulvovaginal candidiasis (CANDIDIASIS, VULVOVAGINAL), and thrush (see CANDIDIASIS, ORAL). (From Dorland, 28th ed)Antifungal Agents: Substances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues.Fluconazole: Triazole antifungal agent that is used to treat oropharyngeal CANDIDIASIS and cryptococcal MENINGITIS in AIDS.Candidiasis, Invasive: An important nosocomial fungal infection with species of the genus CANDIDA, most frequently CANDIDA ALBICANS. Invasive candidiasis occurs when candidiasis goes beyond a superficial infection and manifests as CANDIDEMIA, deep tissue infection, or disseminated disease with deep organ involvement.Drug Resistance, Fungal: The ability of fungi to resist or to become tolerant to chemotherapeutic agents, antifungal agents, or antibiotics. This resistance may be acquired through gene mutation.Candida glabrata: A species of MITOSPORIC FUNGI commonly found on the body surface. It causes opportunistic infections especially in immunocompromised patients.Echinocandins: Cyclic hexapeptides of proline-ornithine-threonine-proline-threonine-serine. The cyclization with a single non-peptide bond can lead them to be incorrectly called DEPSIPEPTIDES, but the echinocandins lack ester links. Antifungal activity is via inhibition of 1,3-beta-glucan synthase production of BETA-GLUCANS.Amphotericin B: Macrolide antifungal antibiotic produced by Streptomyces nodosus obtained from soil of the Orinoco river region of Venezuela.Candida tropicalis: A species of MITOSPORIC FUNGI that is a major cause of SEPTICEMIA and disseminated CANDIDIASIS, especially in patients with LYMPHOMA; LEUKEMIA; and DIABETES MELLITUS. It is also found as part of the normal human mucocutaneous flora.Cross Infection: Any infection which a patient contracts in a health-care institution.Candida albicans: A unicellular budding fungus which is the principal pathogenic species causing CANDIDIASIS (moniliasis).Catheterization, Central Venous: Placement of an intravenous CATHETER in the subclavian, jugular, or other central vein.Antigens, Fungal: Substances of fungal origin that have antigenic activity.Mycology: The study of the structure, growth, function, genetics, and reproduction of fungi, and MYCOSES.Tertiary Healthcare: Care of a highly technical and specialized nature, provided in a medical center, usually one affiliated with a university, for patients with unusually severe, complex, or uncommon health problems.beta-Glucans: Glucose polymers consisting of a backbone of beta(1->3)-linked beta-D-glucopyranosyl units with beta(1->6) linked side chains of various lengths. They are a major component of the CELL WALL of organisms and of soluble DIETARY FIBER.Blood: The body fluid that circulates in the vascular system (BLOOD VESSELS). Whole blood includes PLASMA and BLOOD CELLS.Neutropenia: A decrease in the number of NEUTROPHILS found in the blood.Mannans: Polysaccharides consisting of mannose units.Retrospective Studies: Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.Lipopeptides: Compounds consisting of a short peptide chain conjugated with an acyl chain.Antibodies, Fungal: Immunoglobulins produced in a response to FUNGAL ANTIGENS.Incidence: The number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from PREVALENCE, which refers to all cases, new or old, in the population at a given time.Intensive Care Units: Hospital units providing continuous surveillance and care to acutely ill patients.KuwaitEye Infections, Fungal: Infection by a variety of fungi, usually through four possible mechanisms: superficial infection producing conjunctivitis, keratitis, or lacrimal obstruction; extension of infection from neighboring structures - skin, paranasal sinuses, nasopharynx; direct introduction during surgery or accidental penetrating trauma; or via the blood or lymphatic routes in patients with underlying mycoses.Intensive Care Units, Neonatal: Hospital units providing continuing surveillance and care to acutely ill newborn infants.Candidiasis, Cutaneous: Candidiasis of the skin manifested as eczema-like lesions of the interdigital spaces, perleche, or chronic paronychia. (Dorland, 27th ed)Catheters, Indwelling: Catheters designed to be left within an organ or passage for an extended period of time.MycosesInfant, Newborn: An infant during the first month after birth.Mycological Typing Techniques: Procedures for identifying types and strains of fungi.Microbial Sensitivity Tests: Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses).APACHE: An acronym for Acute Physiology and Chronic Health Evaluation, a scoring system using routinely collected data and providing an accurate, objective description for a broad range of intensive care unit admissions, measuring severity of illness in critically ill patients.Tertiary Care Centers: A medical facility which provides a high degree of subspecialty expertise for patients from centers where they received SECONDARY CARE.Catheter-Related Infections: Infections resulting from the use of catheters. Proper aseptic technique, site of catheter placement, material composition, and virulence of the organism are all factors that can influence possible infection.Drug Resistance, Multiple, Fungal: The ability of fungi to resist or to become tolerant to several structurally and functionally distinct drugs simultaneously. This resistance phenotype may be attributed to multiple gene mutations.Endophthalmitis: Suppurative inflammation of the tissues of the internal structures of the eye frequently associated with an infection.Risk Factors: An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.Itraconazole: A triazole antifungal agent that inhibits cytochrome P-450-dependent enzymes required for ERGOSTEROL synthesis.TriazolesOpportunistic Infections: An infection caused by an organism which becomes pathogenic under certain conditions, e.g., during immunosuppression.Hospitals: Institutions with an organized medical staff which provide medical care to patients.IcelandHematologic Neoplasms: Neoplasms located in the blood and blood-forming tissue (the bone marrow and lymphatic tissue). The commonest forms are the various types of LEUKEMIA, of LYMPHOMA, and of the progressive, life-threatening forms of the MYELODYSPLASTIC SYNDROMES.DNA, Fungal: Deoxyribonucleic acid that makes up the genetic material of fungi.Disk Diffusion Antimicrobial Tests: A method where a culturing surface inoculated with microbe is exposed to small disks containing known amounts of a chemical agent resulting in a zone of inhibition (usually in millimeters) of growth of the microbe corresponding to the susceptibility of the strain to the agent.Immunoassay: A technique using antibodies for identifying or quantifying a substance. Usually the substance being studied serves as antigen both in antibody production and in measurement of antibody by the test substance.

Incidence and predictors of invasive candidiasis associated with candidaemia in children. (1/130)

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Comparison of albicans vs. non-albicans candidemia in French intensive care units. (2/130)

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Relative frequency of albicans and the various non-albicans Candida spp among candidemia isolates from inpatients in various parts of the world: a systematic review. (3/130)

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Candida albicans heme oxygenase and its product CO contribute to pathogenesis of candidemia and alter systemic chemokine and cytokine expression. (4/130)

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Analysis of Candida glabrata strains with reduced sensitivity to micafungin in vitro isolated from a patient with persistent Candidemia. (5/130)

We report the appearance of Candida glabrata strains with reduced sensitivity during treatment with the echinocandin drug micafungin (MCF). Four C. glabrata strains were isolated from sputum, gastric juice, and blood taken from a patient during hospitalization. Two of these strains, one of which was obtained after treatment with MCF for suspected Candida pneumonia and the other of which was obtained during MCF treatment for candidemia, were isolated from blood and found to have a reduced susceptibility to MCF. These two clinical isolates showed a high minimum inhibitory concentration (MIC) for MCF, with this change in MIC being unique for MCF among established antifungal drugs. To further investigate the mechanism underlying this reduced sensitivity, an in vivo mouse infection model and in vitro enzymatic analysis were performed. MCF had little effect in the mouse disseminated infection model and enzymatic analysis showed the low affinity of MCF to the 1,3-Beta-D-glucan synthase of the clinical isolates, although the enzymes of both clinical isolates and control strain were noncompetitively inhibited by MCF. Taken together, this low affinity of MCF for the enzymes is likely to cause the reduced sensitivities. These data further indicate that MCF could induce acquired MCF-resistant strains during clinical use.  (+info)

Recent exposure to caspofungin or fluconazole influences the epidemiology of candidemia: a prospective multicenter study involving 2,441 patients. (6/130)

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Candida bloodstream infections: comparison of species distributions and antifungal resistance patterns in community-onset and nosocomial isolates in the SENTRY Antimicrobial Surveillance Program, 2008-2009. (7/130)

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Candidemia after cardiac surgery in the intensive care unit: an observational study. (8/130)

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Candidemia is an important cause of morbidity and mortality in the healthcare setting. However, there is limited information about risk factors for such infection among elderly patients. A case-control study was conducted during the period 2008-2011. For each case, two controls were selected among patients admitted to the same hospital, and individually matched by sex, age, time of admission, hospital ward and hospitalisation duration. The adjusted odds ratio (OR) was calculated using multiple conditional logistic regression. We identified 145 episodes of candidemia occurring in 140 patients with a median age of 80 years. Candida albicans caused 55% of all candidemia episodes. After adjustment, candidemia was strongly associated with duration of total [duration , 7 days: OR = 20.09; 95% confidence interval (CI): 3.44-117.52] and peripheral parenteral nutrition (duration , 7 days: OR = 26.83; 95% CI: 6.54-110.17), other central vascular catheters (OR = 5.17; 95% CI: 1.24-23.54) and glycopeptide ...
We reviewed 62 episodes (from 59 infants) of neonatal candidemia that occurred between January 1994 and June 1999. Except 5 term babies, all infants were premature (median gestational age [GA], 30 weeks) and birth weight was less than 2500 g (median, 1300 g). Most infants had reported risk factors and other neonatal problems. The age at onset of candidemia ranged from 15 to 173 days with a median of 34 days. In addition to catheter removal, all but one infants received antifungal agents and candidemia was eradicated subsequently in 46 episodes (75%). Eighteen infants with 19 episodes ever received fluconazole therapy. Fluconazole was administered as the first line agent in 6 episodes and successfully cleared candidemia in 5 episodes. Fluconazole was used as an alternative agent in an additional 13 episodes after amphotericin B (am B) +/- flucytosine were given for a period without a satisfactory result and eradication of candidemia was achieved in 8 episodes subsequently. All 18 infants ...
We conducted prospective, active population-based surveillance for candidemia (defined as any Candida species isolated from blood) in Atlanta and San Francisco (total population, 5.34 million) during 1992-1993. The average annual incidence of candidemia at both sites was 8 per 100,000 population. The highest incidence (75 per 100,000) occurred among infants ⩽1 year old. In 19% of patients, candidemia developed prior to or on the day of admission. Underlying medical conditions included cancer (26%), abdominal surgery (14%), diabetes mellitus (13%), and human immunodeficiency virus infection (10%). In 47% of cases, species of Candida other than Candida albicans were isolated, most commonly Candida parapsilosis, Candida glabrata, and Candida tropicalis. Antifungal susceptibility testing of 394 isolates revealed minimal levels of azole resistance among C. albicans, C. tropicalis, and C. parapsilosis. These data document the substantial burden of candidemia and its changing epidemiology. Continued ...
Candida albicans, a constituent of normal microbial flora of human mucosal surfaces, is a major cause of candidemia in immunocompromised individuals and hospitalized patients with other debilitating diseases. Molecular fingerprinting studies have suggested nosocomial transmission of C. albicans based on the presence of clusters or endemic genotypes in some hospitals. However, intrahospital strain transmission or a common source of infection has not been firmly established. We performed multilocus sequence typing (MLST) on 102 C. albicans bloodstream isolates (representing 92% of all culture-confirmed candidemia patients over a 31-month period at seven major hospitals) to identify patient-to-patient transmission or infection from a common source in Kuwait, a small country in the Middle East where consanguineous marriages are common. Repeat bloodstream isolates from six patients and nine surveillance cultures from other anatomic sites from six patients were also analyzed. Fifty-five isolates belonged to
In a previous edition of Critical Care, Shorr and colleagues developed a simple weight risk score for identifying patients with candidemia upon hospital admission [1]. Using recursive partitioning, they determined the best discriminators of Candida bloodstream infections in patients upon hospitalization (identified as a positive blood culture 1 day prior to or 2 days after admission) by retrospectively reviewing the CareFusion Outcomes Research Database, comprising 64,109 bloodstream infection cases admitted to 176 acute care hospitals from 2000 to 2005. Three sets of models were applied (equal weight, unequal weight, and full weight with additional variables) for sensitivity analysis. The risk score was then validated using the 2006/2007 year cohort for a total of 24,685 bloodstream infections.. The rate of candidemia was 1.2% of all bloodstream infections for the 5-year derivation cohort, and was 1.3% for the validation cohort. The rate was increased to 2.3% and 3.1%, respectively, for those ...
Population-based surveillance for candidemia in Australia from 2001 to 2004 identified 1,095 cases. Annual overall and hospital-specific incidences were 1.81/100,000 and 0.21/1,000 separations (completed admissions), respectively. Predisposing factors included malignancy (32.1%), indwelling vascular catheters (72.6%), use of antimicrobial agents (77%), and surgery (37.1%). Of 919 episodes, 81.5% were inpatient healthcare associated (IHCA), 11.6% were outpatient healthcare associated (OHCA), and 6.9% were community acquired (CA). Concomitant illnesses and risk factors were similar in IHCA and OHCA candidemia. IHCA candidemia was associated with sepsis at diagnosis ( ...
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Saeed S, Quintin J, Rao AN, Kerstens H, … Kumar V, et al. Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity. SCIENCE 2014; 345(6204):1251086. 2. Candidemia as a model disease for infectious disease Candidemia is a systemic fungal infection in the bloodstream, mainly caused by Candida albicans; it leads to approximately 150,000 deaths worldwide every year. The only treatments are anti-fungal drugs, which are often ineffective. However, it is difficult to develop new treatment options with our limited knowledge of the host genetic susceptibility factors and their impact on host-Candida interactions, which are central to the development of candidemia. We hypothesize that comprehensive characterization of the genetic and molecular basis of the Candida-specific immune response will pinpoint key susceptibility factors. Identifying the susceptibility pathways will aid the development of new therapies for candidemia. Currently we are testing our hypothesis by ...
The use of improved microbiological procedures associated with molecular techniques has increased the identification of Candida bloodstream infections, even if the isolation of more than one species by culture methods remains uncommon. We report the cases of two children presenting with severe gastrointestinal disorders and other risk factors that contribute to Candida infections. in the first patient, C. albicans DNA was initially detected by a nested-amplification and C. tropicalis was found later during hospitalization, while blood cultures were persistently negative. in the second child, there was amplification of C. albicans and C. glabrata DNA in the same samples, but blood cultures yielded only C. albicans. Both patients received antifungal therapy but had unfavorable outcomes. These two cases illustrate that PCR was more successful than culture methods in detecting Candida in the bloodstream of high risk children, and was also able to detect the presence of more than one species in the ...
National Trends in the Distribution of ,I,Candida,/I, Species Causing Candidemia in Japan from 2003 to 2014:A Report by the Epidemiological Investigation Committee for Human Mycoses in Japan (2018 ...
The incidence of invasive fungal infections is increasing in many hospitals. The National Nosocomial Infections Surveillance (NNIS) program for U.S. hospitals documented a doubling in the rate of nosocomial fungal infections between 1980 and 1990 (4). From 1995 to 1996, Candida species was the fourth most common cause of nosocomial bloodstream infections (BSIs) in the United States (13). In recent years, some studies have reported an increase of candidemia due to Candida non-albicans species, with the threat of increased mortality and antifungal drug resistance (1, 10, 16, 21). The epidemiology of candidemia has been studied primarily in selected hospitals (2, 7, 22); few studies have focused on this problem on a nationwide basis (15, 17). The purpose of this study was to examine candidemia in Iceland during a 20-year period with respect to epidemiology and clinical mycology. Due to the high quality and accessibility of demographic and medical data, Iceland, a 103,000-km2 island in the north ...
IVTEAM #Intravenous literature: Chander, J., Singla, N., Sidhu, S.K. and Gombar, S. (2013) Epidemiology of Candida blood stream infections: experience of a tertiary care centre in North India. Journal of Infection in Developing Countries. 7(9), p.670-5.. Abstract:. INTRODUCTION: Bloodstream infections due to Candida species are becoming a major cause of morbidity and mortality in hospitalized patients. The spectrum of candidemia has changed with the emergence of non-albicans Candida species, especially among critically ill patients.. METHODOLOGY: In a retrospective study (July 2009 to December 2009) on candidemia, various Candida species isolated from blood cultures were characterized and studied along with the determination of their antifungal susceptibility to amphotericin B, itraconazole, and fluconazole by Etest. Probable risk factors for patients in the intensive care unit (ICU) presenting with candidemia were also analyzed.. RESULTS: During the study period, a total of 4651 samples were ...
Abstract: The C. parapsilosis sensu lato group involves three closely related species, C. parapsilosis sensu stricto, C. orthopsilosis and C. metapsilosis. Although their overall clinical importance is dramatically increasing, there are few studies regarding the virulence properties of the species of the psilosis complex. In this study, we tested 63 C. parapsilosis sensu stricto, 12 C. metapsilosis and 18 C. orthopsilosis isolates for the ability to produce extracellular proteases, secrete lipases and form pseudohyphae. Significant differences were noted between species, with the C. metapsilosis strains failing to secrete lipase or to produce pseudohyphae. Nine different clinical isolates each of C. parapsilosis sensu stricto, C. orthopsilosis and C. metapsilosis were co-cultured with immortalized murine or primary human macrophages. C. parapsilosis sensu stricto isolates showed a significantly higher resistance to killing by primary human macrophages compared to C. orthopsilosis and C. ...
SAN DIEGO, Sept. 16, 2019 /PRNewswire/ - Amplyx Pharmaceuticals, a biotech company dedicated to developing innovative therapies for debilitating and life-threatening diseases in patients with compromised immune systems, announced today that two independent review committees completed their planned safety and efficacy assessment of data from 50% of the planned study population enrolled in the Companys Phase 2 open-label clinical trial of fosmanogepix (APX001) for the treatment of candidemia.. The Data Review Committee (DRC) and Data Safety Monitoring Board (DSMB) have reviewed data from the first ten patients. The DRC adjudicated that fosmanogepix demonstrated a high level of treatment success at the end of study drug treatment. Treatment success is defined as clearance of Candida from the blood, patient is alive following treatment, and the patient received no other systemic antifungal therapies following initiation of study drug. Following review of the safety data, the DSMB recommended that ...
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4months: not established. Give by slow IV infusion over 1 hour. ≥4months: Candidemia, acute disseminated, peritonitis, abscesses: 2mg/kg once daily; max 100mg/day. Esophageal: (≤30kg): 3mg/kg once daily; (,30kg): 2.5mg/kg once daily. Max: 150mg/day. Prophylaxis in HSCT: 1mg/kg once daily; max 50mg/day.. ...
Our survey demonstrates that the risk of nosocomial blood stream infections has nearly doubled for patients admitted to our hospital between 1986 and 1996, as a result of small but relentless increases from 1986 to 1995, followed by a large in-crease between 1995 and 1996. Because our surveillance tech-nique, definitions of infection and number of […] ...
Looking for online definition of candidaemia in the Medical Dictionary? candidaemia explanation free. What is candidaemia? Meaning of candidaemia medical term. What does candidaemia mean?
This study will create an international multi-center cohort of children with new clinical concern for infection while in the hospital. Sites used are part of the International Pediatric Fungal Network (ipfn.org). The study plans to prospectively enroll pediatric patients at high-risk of developing invasive candidiasis over a four year period. The study duration per subject will be up to 14 days for blood collection and 30 days for data collection from the medical record.. For the first aim, this study will assemble a prospective cohort of pediatric patients at high-risk for developing invasive candidiasis. Blood samples for biomarker testing will be obtained within 24-hours of a patient having a clinical indication for blood culture attainment. To accomplish the second aim, additional blood sampling will be performed in the sub-set of patients that are found to have invasive candidiasis. For the third aim, remnant blood samples following biomarker testing from all consenting participants will be ...
Invasive candidiasis is associated with high mortality, particularly in adults. Retrospective studies show that shorter times to treatment are correlated with a lower risk of death. A number of factors can be used to predict which patients would benefit from antifungal prophylaxis or early (pre-emptive or empirical) therapy. Detection of the fungal cell wall component (1-->3)-beta-D-glucan (BDG) shows promise as an early biomarker of invasive fungal infection and may be useful in identifying patients who would benefit from early antifungal treatment. To date, no consistent early treatment strategy has evolved. Proof-of-concept studies are needed to assess the role of pre-emptive and empirical therapy in ICU patients and the relevance of BDG as an early marker of infection ...
Symptoms of cadidiasis vary based on the area infected, although most infections result in such minimal symptoms as redness, itching and discomfort. In immunocompotent patients - those displaying a normal immune system response - cadidiasis is generally a localized infection of the skin or mucosal membranes, such as the mouth, the pharynx or eosophagus, the bladder, or the genitals. It can effect the eosophagus, which carries the risk of becoming a systemic infection. Systemic candidiasis can lead to candidemia, a much more severe form of infection with more complex complications ...
The aims of the present study are to investigate the prevalence and the epidemiology of candidaemia and to determine the antifungal susceptibility patterns of Candida spp. isolates from a tertiary-care hospital in Italy ...
BACKGROUND: Candida bloodstream infection is associated with high mortality. Infectious disease consultation improves outcomes in several infections, including Staphylococcus aureus and cryptococcosis, as well as multidrug-resistant organisms. We aimed to examine the association between infectious disease consultation and differences in management with mortality in candida bloodstream infections.. METHODS: In this retrospective, single-centre cohort study, we reviewed the medical charts of all patients admitted to Barnes-Jewish Hospital (St Louis, MO, USA), a tertiary referral centre, aged 18 years or older with candida bloodstream infection from 2002 to 2015. We collected data for demographics, comorbidities, predisposing factors, all-cause mortality, antifungal use, central-line removal, and ophthalmological and echocardiographic evaluation to assess 90-day all-cause mortality between individuals with and without an infectious disease consultation. For the survival analysis we used Cox ...
An 18-month epidemiologic investigation of Candida bloodstream infections in a Singapore hospital identified 52 candidemic patients: 36% of whose infections were caused by C. tropicalis, 29% were due to C. albicans, 10% with C. parapsilosis and 21% involved C. glabrata. A predominant clonal C. tropicalis strain was demonstrated. No association with ICU stay, prior exposure to fluconazole/broad-spectrum antibiotics or increased mortality was found in this apparent shift towards non-C. albicans Candida species as the primary agents of candidemia ...
Background: Use of fluconazole (FLU) in treatment of candidemia has been questioned due to variations in in-vitro susceptibilities of different Candida species to FLU. Significance of in-vitro differences on patient outcomes and efficacy of FLU for C. glabrata fungemia (Cg) remains unknown. The objective was to determine how frequently antifungal treatment is changed among patients diagnosed with Cg; and to evaluate outcome of patients with Cg, treated with FLU regimen (FR) vs non-FLU regimen (NFR). Methods: Patients with candidemia at St. John Hospital were identified by review of microbiology from February 2003 until February 2006. Following data was collected on patients with Cg: age, gender, comorbid illness, risk factors for candidemia, duration of infection, antifungal therapy (dose, duration and changes made in response to culture results), and patient outcomes. Cg patients were compared with age and gender matched control patients with C. albicans fungemia (Ca). Results: Among 152 ...
2. Plasma (1→3)-ß-D-glucan and fungal antigenemia in patients with candidemia, aspergillosis, and cryptococcosis.. T Miyazaki, S Kohno, K Mitsutake, S Maesaki, K Tanaka, N Ishikawa, and K Hara. Second Department of Internal Medicine, Nagasaki University School of Medicine, Japan. (1→3)-ß-D-Glucan is one of the major structural components of fungi, and it seems that it can be detected by the fractionated (1→3)-ß-D-glucan-sensitive component from a Limulus lysate, factor G. We evaluated the concentration of (1→3)-ß-D-glucan by using factor G and other fungal antigens in 24 patients with clinical evidence of mycosis and 36 healthy subjects. The mean concentration of (1→3)-ß-D-glucan in the plasma of the healthy subjects was found to be 2.7 +/- 1.9 pg/mL (range, < 6.9 pg/mL), and it was found to be substantially higher in all 11 patients with candidemia (mean, 2,207.4 pg/mL; range, 325.4 to 8,449.0 pg/mL). Eight of those 11 patients with candidemia (73%) were positive for the Cand-Tec ...
[115 Pages Report] Check for Discount on Global Blood Stream Infection Testing Market Research Report 2017 report by QYResearch Group. In this report, the global Blood Stream Infection Testing market...
Very strong in vitro proteinase activity was detected in all isolates of C. parapsilosis sensu stricto and C. orthopsilosis, whereas only two isolates of C. metapsilosis showed positive enzymatic activity. Treviño-Rangel et al.2 also observed proteinase activity in three species of the complex. Several studies have shown that Candida parapsilosis complex species express different proteinase activities. Silva et al.6 found positive protease activity in 37.7% isolates of C. parapsilosis sensu stricto; however, only 7.8% of the isolates revealed high enzymatic activity. Furthermore, none of the C. metapsilosis and C. orthopsilosis isolates exhibited protease activity in that study.. Some studies on the virulence of Candida species verified that few isolates of the C. parapsilosis complex have proteinase activity, regardless of whether the isolation site was nail or blood1,7. Our research identified significantly higher enzymatic activity of proteinase in isolates from blood than from nails (Figure ...
The blood culture test market is categorized on the basis of methods, products, applications, end users, and regions. Factors such as increasing demand for rapid diagnostic techniques, high prevalence of infectious diseases, increase in healthcare expenditure and rising aging population are driving the growth of this market. Moreover, increasing blood stream infections (BSI) is another major factor propelling the growth of this market. According to the U.S. CDC (Centres for Disease Control and Prevention), catheter-related blood stream infection (CRBSI) is the most common cause for healthcare-associated blood stream infection. Around 12% to 25% of patients who acquire BSI die every year while some of them have to prolong their hospital stay leading to increase in the overall treatment cost. A treatment of CRBSI can cost up to $56,000, once the cost of pharmacy increases, the cost of catheter and additional diagnostic tests also increases which leads to the increase in the overall healthcare cost ...
Recently, studies focusing on ward-based nurse screenings for sepsis have also demonstrated benefit. A study from Norway targeted early identification of in-hospital sepsis by ward nurses [8]. As part of the Mid-Norway Sepsis Study, the study assessed the impact of a bundle intervention consisting of a flow chart for sepsis identification and physician notification and a clinical tool for triage of patients exhibiting signs of sepsis and organ failure. Additionally, a 4-h training course was provided to all nurses and nursing students working on the wards that included content on pathophysiology, signs of sepsis, and treatment recommendations, including the importance of fluid resuscitation, antibiotic therapy, and monitoring and communication of patient vital signs and condition status changes.. In comparison to a pre-intervention group of 472 patients with confirmed blood stream infection during a 2-year period, 409 patients with confirmed blood stream infection in a 2-year post-intervention ...
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The risk factors for and clinical features of bloodstream infection with uncommon Candida spp. (species other than C. albicans, C. glabrata, C. parapsilosis, C. tropicals and C. krusei) are incompletely defined. To identify clinical variables associated with these species that might guide management, 57 cases of candidaemia resulting from uncommon Candida spp. were analysed in comparison with 517 episodes of Candida albicans candidaemia (2001-2004). Infection with uncommon Candida spp. (5.3% of candidaemia cases), as compared with C. albicans candidaemia, was significantly more likely to be outpatient-acquired than inpatient-acquired (15 of 57 vs. 65 of 517 episodes, p 0.01). Prior exposure to fluconazole was uncommon (n = 1). Candida dubliniensis was the commonest species (n = 22, 39%), followed by Candida guilliermondii (n = 11, 19%) and Candida lusitaniae (n = 7, 12%).C. dubliniensis candidaemia was independently associated with recent intravenous drug use (p 0.01) and chronic liver disease ...
This study aimed at identifying strains of the C. parapsilosis complex isolated from animals, as well as to assess their in vitro antifungal susceptibility profile and in vitro production of virulence attributes. We used 28 isolates of C. parapsilosis (sensu lato) recovered from clinically healthy animals. The strains were phenotypically characterized, followed by molecular identification of the species through PCR-Restriction Enzyme Analysis. Then, the susceptibility of the strains to amphotericin B, itraconazole, voriconazole, fluconazole and caspofungin was assessed through broth microdilution, according to CLSI (M27-A3). Additionally, the ability of the strains to produce biofilm, phospholipases and proteases was analyzed. Molecular analysis showed thirteen C. parapsilosis (sensu stricto), ten C. orthopsilosis and five C. metapsilosis strains. In vitro resistance to fluconazole was observed in three strains of C. parapsilosis (sensu stricto) and two C. metapsilosis. All tested strains were ...
Echinocandins, such as anidulafungin are first line treatment for candidemia or invasive candidiasis in critically ill patients. There is conflicting data on the pharmacokinetic properties of anidulafungin in ICU patients. Adult ICU patients (from 3 hospitals) receiving anidulafungin for suspected or proven fungal infections were included. Patient were considered evaluable ... read more when a pharmacokinetic curve on day 3 could be completed. 23 out of 36 patients (7 female, 16 male) were evaluable. Median (range) age and bodyweight were 66 (28-88) yr and 76 (50-115) kg. Pharmacokinetic sampling on day 3 (n=23) resulted in a median anidulafungin AUC0-24h of 72.1 (IQR 61.3-94.0) mg*h*L(-1), a median C24 of 2.2 (IQR 1.9-2.9) mg/L, a median Cmax of 5.3 (IQR 4.1-6.0) mg/L, a median Vd of 46.0 (IQR 32.2-60.2) L and a median CL of 1.4 (IQR 1.1-1.6) L*h-1. Pharmacokinetic sampling on day 7 (n=13) resulted in a median AUC0-24h of 82.7 (IQR 73.0 - 129.5) mg*h*L(-1), a median Cmin of 2.8 (IQR 2.2 - 4.2) ...
Candidaspecies are a common cause of fungal endophthalmitis. This infection arises in two distinct ways:The endogenous form follows candidemia, with hematogenous seeding of the eye. Fungi usually first seed the highly vascular choroid, then infection
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Hospicasp 70 mg Injection is used for invasive aspergillosis , candidemia, esophageal candidiasis etc. Know Hospicasp 70 mg Injection uses, side-effects, composition, substitutes, drug interactions, precautions, dosage, warnings only on | Practo
Question - How long does celexa take to enter your blood stream and how long does it stay in blood stream once stop taking it ?. Ask a Doctor about uses, dosages and side-effects of Celexa, Ask a General & Family Physician
Instant treatment is absolute vital for patients developing sepsis. Providing a specific therapy early on is key. To manage this the pathogenic organisms need to be identified accurately. But a fungal sepsis can still be a hard nut to crack. A new method was developed in the ImSpec project that is now capable to identify pathogenic fungi not only faster, but more reliably. Dr. Wolfgang Fritsche explains MEDICA-tradefair.com exactly how this method works ...
TY - JOUR. T1 - Proteinase and phospholipase activity as virulence factors in Candida species isolated from blood. AU - Mohan das, Vinitha. AU - Ballal, Mamatha. PY - 2008/1/1. Y1 - 2008/1/1. N2 - The number of nosocomial blood stream infections due to Candida species has increased over the past few decades. In order to establish an infection, opportunistic pathogens have to evade the immune system, survive, divide in the host environment, and spread to other tissues. Proteinase and phospholipase secretion has been implicated as potential virulence factors for some Candida species responsible for catheter related candidemia in intensive care unit (ICU) patients with indwelling devices. We therefore have aimed at demonstrating the secretion of proteinase and phospholipase enzymes as virulent factors by Candida species isolated from blood samples collected from ICUs, dialysis units and oncology units. One hundred and fourteen isolates of Candida species were obtained from the blood samples and the ...
These tools will help your unit implement evidence-based practices and eliminate central line-associated blood stream infections (CLABSI). When used with the CUSP (Comprehensive Unit-based Safety Program) Toolkit, these tools dramatically reduced CLABSI rates in more than 1,000 hospitals across the country ...
Candida parapsilosis is frequently isolated from hospital environments, like air and surfaces, and causes serious nosocomial infections. Molecular studies provided evidence of great genetic diversity within the C. parapsilosis species complex but, despite their growing importance as pathogens, little is known about their potential to cause disease, particularly their interactions with phagocytes. In this study, clinical and environmental C. parapsilosis isolates, and strains of the related species C. orthopsilosis and C. metapsilosis were assayed for their ability to induce macrophage cytotocixity and secretion of the pro-inflammatory cytokine TNF-α, to produce pseudo-hyphae and to secrete hydrolytic enzymes. Environmental C. parapsilosis isolates caused a statistically significant (p = 0.0002) higher cell damage compared with the clinical strains, while C. orthopsilosis and C. metapsilosis were less cytotoxic. On the other hand, clinical isolates induced a higher TNF-α production compared with
Members can review presentation slides in the Members-Only section. Sunday, 24 June. 13:00 - 20:00 Registration Open. 15:30 - 16:15 Plenary Session 1. Chairman: C. Kauffmann (USA. Immune Reconstitution after HSCT H. Einsele (GER). Merck Sharp & Dohme Satellite Symposium. 16:30 - 18:30 Important Considerations for Limiting the Impact of Invasive Fungal. Infections in Immuncompromised Patients. Chairmen: C. Viscoli (ITA) & D. Kontoyiannis (USA). 16:30 - 16:40 Welcome & Opening Remarks. C. Viscoli (ITA). 16:40 - 17:05 Unmet Medical Needs for the Management of Invasive Fungal Infections. D. Kontoyiannis (USA). 17:05 - 17:30 Current Treatment strategies for Management of Invasive Aspergillosis. C. Viscoli (ITA). 17:30 - 17:55 Current Strategies for Management of Candidemia and Invasive Candidiasis. M. Bassetti (ITA). 17:55 - 18:20 Panel Discussion. Factuly. 18:20 - 18:30 Closing Remarks. D. Kontoyiannis (USA). 19:00 - 20:00 Welcome Reception. Monday, 25 June. 08:00 - 09:00 Meet-the-Expert ...
Candida species are commensally microorganisms in healthy individuals, but is also the most opportunistic fungal pathogen of human. From benign skin-mucosal forms to invasive ones, Candida infection, can compromise various organs systematic and cause diseases in immunocompromised or critically ill patients.
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理化学研究所 脳科学総合研究センター(理研BSI)、馬塚 れい子, Ph.D.の概要ページ。研究内容や主要論文などを掲載しています。
Candida of treated c. Dubliniensis fungemia. Candida dubliniensis meningitis as not on time sequela of treated c. Dubliniensis fungemia sebastian j. Van hal,* damien stark,* john harkness,* and deborah.. The epidemiology of candida glabrata and candida. The epidemiology of candida glabrata and candida albicans fungemia in immunocompromised patients with cancer gerald p. Bodey, md, masoud.. Candidiasis wikipedia. Greater than 20 kinds of candida can cause contamination with candida albicans a fungemia referred to as candidemia. Of precise treatment regimens for candida.. Fungemia wikipedia. Fungemia or fungaemia is the presence of fungi or yeasts in the blood. The most commonplace type, additionally called candidemia, candedemia, or systemic candidiasis, is.. Holistic treatment for candida contamination. · yeast infections can be painful, even agonizing, however instantaneous relief from a yeast infection is not presently viable. Candida albicans is a cussed.. Candidemia symptoms & remedy ...
|p| Infections caused by non-albicans Candida spp. are an important medical problem in people from risk groups, e.g. hematooncological patients. The aim of this paper was to analyse the in vitro activity of micafungin against 30 clinical isolates of non-albicans Candida spp. (C. glabrata, C. famata, C. tropicalis, C. inconspicua, C. lusitaniae, C. parapsilosis, C. krusei) by way of the E-test procedure, allowing determination of minimal inhibitory concentration (MIC). Data presented in this paper indicate that most of the studied clinical isolates - 27 (90%) showed sensitivity to micafungin, with MIC values ranging from 0.004 to 2 mg/l, while 3 (10%) isolates, including 2 isolates of C. tropicalis and 1 isolate of C. famata, were resistant to micafungin, with MIC values > 32 mg/l. The MIC|sub|50|/sub| and MIC|sub|90|/sub| values of micafungin, defined as MIC inhibited growth of 50% or 90% of the isolates studied, were 0.008 mg/l or 2 mg/l, respectively. In the case of C. glabrata isolates, MICs
... , or invasive candidiasis, is a fungal infection of Candida spp. It usually presents as candidemia and progresses to several viscera (ie, liver, kidney, spleen, eyes, brain, and heart). Candida spp are among the most common causes of nosocomial bloodstream infections typically introduced from the gastrointestinal tract or from venous catheters.1 Clinical manifestations of candidiasis can be nonspecific but may include unresolved fever and may progress to sepsis. Definitive diagnosis requires histopathologic confirmation, but presumptive diagnosis is used frequently in high-risk immunosuppressed or neutropenic patients. Pharmacologic intervention is required with a confirmed positive culture, and catheter removal is recommended for suspected infections.2 The most common pathogen for invasive candidiasis is C albicans (41%-65%); however, non-albicans Candida spp resistant to conventional treatments have emerged as prevalent causes of candidiasis, including C ...
BACTERIAL BLOOD STREAM INFECTIONS NEGATIVELY IMPACT ON OUTCOME OF PATIENTS TREATED WITH ALLOGENEIC STEM CELL TRANSPLANTATION: 6 YEARS SINGLE-CENTRE EXPERIENCE
BACTERIAL BLOOD STREAM INFECTIONS NEGATIVELY IMPACT ON OUTCOME OF PATIENTS TREATED WITH ALLOGENEIC STEM CELL TRANSPLANTATION: 6 YEARS SINGLE-CENTRE EXPERIENCE
Candida albicans is the most pathogenic Candida species but shares many phenotypic features with Candida dubliniensis and may, therefore, be misidentified in clinical microbiology laboratories. Candidemia cases due to C. dubliniensis are increasingly being reported in recent years. Accurate identification is warranted since mortality rates are highest for C. albicans infections, however, C. dubliniensis has the propensity to develop resistance against azoles more easily. We developed a duplex PCR assay for rapid detection and differentiation of C. albicans from C. dubliniensis for resource-poor settings equipped with basic PCR technology and compared its performance with three phenotypic methods. Duplex PCR was performed on 122 germ tube positive and 12 germ tube negative isolates of Candida species previously identified by assimilation profiles on Vitek 2 ID-YST system. Typical morphologic characteristics on simplified sunflower seed agar (SSA), and reaction with a commercial (Bichro-Dubli) latex
BACKGROUND: Candida peritonitis in postoperative patients is an independent predictor of mortality. Empirical early antifungal therapy should be started in these patients, since according to the results of studies in patients with candidemia, this has an impact on the prognosis. The treatment recommended by clinical practice guidelines in patients with haemodynamic instability are candins, but they do not make explicit recommendations for patients with dysfunction of other organs, or high lactate levels ...
IV (Adults): Esophageal candidiasis-150 mg/day for 15 days (range 10-30 days); Candidemia/acute disseminated candidiasis/Candida peritonitis and abscesses-100 mg/day for 15 days (range 10-47 days); Prevention of Candida infections in stem cell transplantation-50 mg/day. ...
CRBSIs (catheter-related bloodstream infection) continue to be associated with considerable morbidity and mortality and cause high treatment costs.
Candida parapsilosis ATCC ® 22019D-5™ Designation: Genomic DNA from Candida parapsilosis strain CBS 604 (ATCC ® 22019™) Application:
Definition of blood stream in the Legal Dictionary - by Free online English dictionary and encyclopedia. What is blood stream? Meaning of blood stream as a legal term. What does blood stream mean in law?
Pediatric ICUs that consistently get it right on central line insertion and maintenance can dramatically and durably cut blood stream infection rates, an observational trial showed.
A new study may change our understanding of bacteremia, a bloodstream infection commonly seen in preterm infants in neonatal intensive care units.
Nano technology is really making some inroads into medical science for better diagnosis and treatment of diseases. Scientists at the University of Stuttgart have created another application of practical nano technology which gives us a glimpse of the future. They have built a three-lens camera which is no bigger than the width if two human hair and can be injected right into the blood stream. The small size of this camera comes courtesy 3D printing technology. Focal point of this camera unit is just 3mm away from the lenses and has a width of 100 micrometers ...
The 2009 IDSA candidemia guidelines recommend evaluating recent exposure to azoles when selecting either fluconazole or an echinocandin for the empirical management of candidemia in nonneutropenic patients (15). An echinocandin is recommended as initial empirical therapy for patients with recent exposure to azoles, due to potential concerns about the isolation of fluconazole-nonsusceptible Candida species. Earlier studies that assessed the relationship between fluconazole and nonsusceptible Candida species focused on risk variables associated with specific Candida species (4, 10, 17, 18). More-recent studies evaluated risk factors for fluconazole-nonsusceptible Candida isolates (7, 11, 21). Exposure to any antifungal was identified as an independent variable associated with reduced fluconazole susceptibility among various Candida species, including C. albicans, C. tropicalis, and C. parapsilosis (13). Prior exposure to fluconazole was identified as an independent risk factor for C. glabrata ...
RESULTS: Fifteen cases of neonatal fungal sepsis were recruited. Over the study period, the incidence of neonatal fungal sepsis was 0.52%, while it was 2.5% in very low birth weight infants. Clinical characteristics were nonspeci-fic. All the infants were treated with parenteral nutrition and broad spectrum antibiotics. Peripheral inserted central catheter (PICC) was placed in thirteen patients. Pathogenic analyses indicated Candida glabrata was the main pathogen in our study. All the pathogens were sensitive to amphotericin B. Only one Candida glabrata was resistant to fluconazole. Thirty-four cases of bacterial sepsis were included. The clinical characteristics and laboratory examination results were compared. The platelet count was 61×109/L in fungal group, while the platelet count was 178×109/L in bacterial group. There was statistical difference between the fungal group and bacterial group (P=0.004). The rate of thrombocytopenia was 80.0% in fungal group, while it was 29.4% in bacterial ...
This study prospectively evaluated an 18S rRNA gene-targeted real-time PCR approach in comparison with standard blood culture (BC) diagnostics for rapid diagnosis of candidaemia in a large study population of 384 patients, including 902 whole blood samples from 468 infectious episodes (IEs) of 329 adults and 55 children with haematological malignancies and various forms of immunodeficiency, and intensive care unit patients. Seven out of eight BC-proven cases (87.5 %) of candidaemia and seven out of twelve BC-positive samples (58.3 %) were positive by the Candida-specific PCR. A positive PCR result was also obtained for 28/460 BC-negative samples from IEs, including 8 patients with culture-confirmed Candida infection at primary sterile body sites. Of the PCR-positive, culture-negative patients, more than 50 % received systemic antifungal therapy. In 432/460 BC-negative IEs, the Candida specific-PCR was negative, resulting in a negative predictive value of 99.8 %. In conclusion, the Candida specific-PCR
TY - JOUR. T1 - Risk factors for and clinical implications of mixed Candida/bacterial bloodstream infections. AU - Kim, S. H.. AU - Yoon, Young Kyung. AU - Min, Ja Kim. AU - Sohn, Jang Wook. PY - 2013/1/1. Y1 - 2013/1/1. N2 - Mixed Candida/bacterial bloodstream infections (BSIs) have been reported to occur in more than 23% of all episodes of candidaemia. However, the clinical implications of mixed Candida/bacterial BSIs are not well known. We performed a retrospective case-control study of all consecutive patients with candidaemia over a 5-year period to determine the risk factors for and clinical outcomes of mixed Candida/bacterial BSIs (cases) compared with monomicrobial candidaemia (controls). Thirty-seven (29%) out of 126 patients with candidaemia met the criteria for cases. Coagulase-negative staphylococci were the predominant bacteria (23%) in cases. In multivariate analysis, duration of previous hospital stay ≥7weeks (odds ratio (OR), 2.86; 95% confidence interval (CI), 1.09-7.53), ...
A 63-year-old female with candidemia following necrotizing pancreatitis developed clinical signs of chorioretinitis and underwent the systemic administration of voriconazole, after which anterior chamber inflammation and multiple, white, fluffy, chorioretinal lesions, under 1mm in diameter, were gra...
BACKGROUND. CAR T cells are a promising therapy for hematologic malignancies. B cell maturation antigen (BCMA) is a rational target in multiple myeloma (MM). METHODS. We conducted a phase I study of autologous T cells lentivirally transduced with a fully human, BCMA-specific CAR containing CD3ζ and 4-1BB signaling domains (CART-BCMA), in subjects with relapsed/refractory MM. Twenty-five subjects were treated in 3 cohorts as follows: cohort 1, 1 × 108 to 5 × 108 CART-BCMA cells alone; cohort 2, cyclophosphamide (Cy) 1.5 g/m2 plus 1 × 107 to 5 × 107 CART-BCMA cells; cohort 3, Cy 1.5 g/m2 plus 1 × 108 to 5 × 108 CART-BCMA cells. No prespecified BCMA expression level was required. RESULTS. CART-BCMA cells were manufactured and expanded in all subjects. Toxicities included cytokine release syndrome and neurotoxicity, which were grade 3-4 in 8 (32%) and 3 (12%) subjects, respectively, and reversible. One subject died at day 24 from candidemia and progressive myeloma, following treatment for ...
BACKGROUND. CAR T cells are a promising therapy for hematologic malignancies. B cell maturation antigen (BCMA) is a rational target in multiple myeloma (MM). METHODS. We conducted a phase I study of autologous T cells lentivirally transduced with a fully human, BCMA-specific CAR containing CD3ζ and 4-1BB signaling domains (CART-BCMA), in subjects with relapsed/refractory MM. Twenty-five subjects were treated in 3 cohorts as follows: cohort 1, 1 × 108 to 5 × 108 CART-BCMA cells alone; cohort 2, cyclophosphamide (Cy) 1.5 g/m2 plus 1 × 107 to 5 × 107 CART-BCMA cells; cohort 3, Cy 1.5 g/m2 plus 1 × 108 to 5 × 108 CART-BCMA cells. No prespecified BCMA expression level was required. RESULTS. CART-BCMA cells were manufactured and expanded in all subjects. Toxicities included cytokine release syndrome and neurotoxicity, which were grade 3-4 in 8 (32%) and 3 (12%) subjects, respectively, and reversible. One subject died at day 24 from candidemia and progressive myeloma, following treatment for ...
Viscoli, C. Recent Advances in the Management of Invasive Candidiasis. Drugs 69, 1-3 (2009). https://doi.org/10.2165/11315490-000000000-00000. Download ...
Blood fungus, also known as fungal sepsis or a "systemic fungal infection," according to the Anaesthetist website on fungal infections, is a fungal "colonization" that starts in the bloodstream, but can spread to other parts of the body. Pathogenic blood fungus is an increasing problem in hospitals worldwide, according to a Centers for Disease Control website. ...
Results: Twenty-four cases were encountered at our institution (20 cases with A. hydrophila, 2 with A. caviae, and 2 with A. veronii biovar sobria bacteremia) during the 16-years study period. The median age of patients was 69 years (range: 17-92) and the majority were men (17/24; 70.8%). Sixteen patients (66.8%) had gastrointestinal manifestation such as diarrhea, vomit, and abdominal pain, and 15 (63%) had jaundice. Bacteremia occurred most often in patients with disease of the hepatobiliary or pancreatic system (45.8%; including 5 pancreatic cancer, 2 cholangiocarcinoma, 2 gallbladder tumor, and 2 liver cirrhosis) and gastrointestinal cancer (16.7%). According to our literature review including our 24 cases, the most frequent pathogen isolated was A. hydrophila (44/73; 60.3%). There was 25 patients (34.2%) with polymicrobial Aeromonas bacteremia and community-acquired blood stream infections due to Aeromonasspecies occurred in 51.6% patients. The overall 30-day mortality was 28.8%. ...
Pfizer Limited today welcomes the Scottish Medicines Consortium (SMC) advice, which recommends Ecalta (anidulafungin), a new antifungal medicine for the treatment of invasive candidiasis in NHS Scotland.1 Following a re-submission, the SMCs decision to recommend anidulafungin comes after results of the cost-minimisation analysis which indicated that anidulafungin would be preferred to both caspofungin and liposomal amphotericin B, with savings of 772 and 2,375 respectively, as a
Candida tropicalis is a diploid ascomycetes yeast responsible for 4%-24% of candidemia. Resistance to flucytosine is rarely described for this species but was observed for 45 (35%) of 130 C. tropicalis isolates recovered from blood cultures in the Paris area in a 4-year survey. The aims of this study were to test the hypothesis that the flucytosine-resistant isolates could represent a subgroup and to determine the relationship between epidemiologic and genomic data. Epidemiologic data and gene sequences were analyzed, and molecular typing was performed. Our results suggest that a clone of flucytosine-resistant isolates, associated with malignancies and a lower mortality than that for other C. tropicalis isolates, is widespread in the Paris area. We propose the analysis of 2 polymorphic microsatellite markers coupled with URA3 sequencing to track the clone.
Title:Emerging Virulence, Drug Resistance and Future Anti-fungal Drugs for Candida Pathogens. VOLUME: 18 ISSUE: 9. Author(s):Vartika Srivastava, Rajeev Kumar Singla and Ashok Kumar Dubey*. Affiliation:Division of Biological Sciences and Engineering, Netaji Subhas Institute of Technology, New Delhi, Division of Biological Sciences and Engineering, Netaji Subhas Institute of Technology, New Delhi, Division of Biological Sciences and Engineering, Netaji Subhas Institute of Technology, New Delhi. Keywords:Candidemia, Candida pathogenicity, Virulence factors, Antifungal drugs, Antifungal drug resistance, Anti-mycotic drugs.. Abstract:Increased incidences of Candida infection have augmented morbidity and mortality in human population, particularly among severely immunocompromised patients and those having a long stay in hospitals (nosocomial infections). Many virulence factors and fitness attributes are reported to be associated with the pathogenicity of Candida sp. It can cause infections ranging ...
GenMark Diagnostics has secured CE Mark under the European In‐Vitro Diagnostic Devices Directive (98/79/EC) for its ePlex blood culture identification fungal pathogen (BCID-FP) panel. BCID-FP is the first panel in the GenMark Sepsis Solution, which will also include BCID Gram-Positive and Gram-Negative panels.. "We are very pleased to bring the first of our three blood culture identification panels to the European market. Rapid diagnosis of blood stream infections can have significant impact on improving patient outcomes and reducing cost of therapy.. GenMarks approach will enable this by providing the broadest pathogen inclusivity and drug resistance markers of any multiplex molecular solution on the market today," said Hany Massarany, President and Chief Executive Officer of GenMark.. "Fungal blood stream infections are some of the most critical conditions we face in the clinical laboratory and diagnosing them quickly and accurately has a significant positive impact on patient ...
In this before-after study, different new methods for bacterial species identification from positive blood cultures will be compared towards historic controls...
An improvement resource to help health and social care economies reduce the number of Gram-negative bloodstream infections (BSIs) with an initial focus on Escherichia coli (E.coli).
This study shows a sharp upswing in some potentially lethal hospital infections in the summer months. Hospitals must be on the alert for spread of infections in warm weather.
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MIT and University of Rochester researchers report important advances toward a therapeutic device that has the potential to capture cells as they flow through the blood stream and treat them. Among ot...
Definition of invasive candidiasis invasive candidiasis. Remedy; healthcare invasive candidiasis is a critical contamination which can have an effect on the blood candida can enter the bloodstream and purpose an infection. A. Candida contamination of the bloodstream candidemia. Candida contamination? Candida contamination candida is in your blood move, there are 17 one of a kind species of candida. Of these, candida albicans (c. Albicans), Candidiasis webmd. · candida albicans is a usually harmless yeast contamination observed within the mouth,intestinal tract,and vagina. Candidiasis is an infection the blood, the. Candida albicans blood infection remedy doylestown. ** candida albicans blood contamination treatment ** yeast infection vs std antibiotics save you yeast infection candida albicans blood contamination remedy treatment. Nine candida signs and symptoms & 3 steps to deal with them dr. Axe. 9 candida signs & three steps to deal with them. What is candida? Candida albicans is the maximum ...
TY - JOUR. T1 - MSG-10. T2 - a Phase 2 study of oral ibrexafungerp (SCY-078) following initial echinocandin therapy in non-neutropenic patients with invasive candidiasis. AU - Mycoses Study Group AU - Spec, Andrej. AU - Pullman, John. AU - Thompson, George Richard. AU - Powderly, William G.. AU - Tobin, Ellis H.. AU - Vazquez, Jose. AU - Wring, Stephen A.. AU - Angulo, David. AU - Helou, Silvia. AU - Pappas, Peter G.. PY - 2019/10/1. Y1 - 2019/10/1. N2 - OBJECTIVES: To evaluate the safety and efficacy of two dosing regimens of oral ibrexafungerp (formerly SCY-078), a novel orally bioavailable β-glucan synthase inhibitor, in subjects with invasive candidiasis versus the standard of care (SOC) and to identify the dose to achieve target exposure (15.4 μM·h) in ,80% of the intended population. METHODS: In a multinational, open-label study, patients with documented invasive candidiasis were randomized to receive step-down therapy to one of three treatment arms: two dosing regimens of novel oral ...
Anidulafungin is an antifungal medication that fights infections caused by fungus. Anidulafungin treats candida (yeast) infections in the blood, or in the stomach or esophagus. Anidulafungin may also be used for purposes not listed in this medication guide.
Bloodstream infections related to the use of central venous catheters (CVCs) are a significant cause of morbidity and mortality for patients in surgical in
A protocol for urgent-start peritoneal dialysis results in less blood stream infections and appears to reduce mortality when compared to urgent-start
Question - Suffering from candida infection, normal sugar test, had taken regesterone continuously for 2-3 cycles to delay periods. Side effect of medicine?. Ask a Doctor about diagnosis, treatment and medication for Candidiasis, Ask an OBGYN, Gynecologic Oncology
A sweeping study on the issue of antibiotic-resistant bacteria in hospitals shows that using antimicrobial soap and ointment on all intensive-care patients significantly decreases bloodstream infection. The results, which are being presented for the first time at IDWeek 2012TM, may suggest a major change in health care practice that could help save lives.
Harvard scientists are developing a device known as the spleen-on-a-chip, for treating sepsis by filtering pathogens from the blood.
The most common type, also known as candidemia, candedemia, or systemic candidiasis, is caused by Candida species, but ... Neutropenic vs non-neutropenic candidemia is treated differently.[4]. An intravenous echinocandin such as anidulafungin, ... caspofungin or micafungin is recommended as first-line therapy for fungemia, specifically candidemia.[4] Oral or intravenous ...
Most had persistent candidemia and a high mortality rate was observed. All isolates were of the same clonal strain and were ... 2015), "Draft genome sequence of a fluconazole-resistant Candida auris strain from a candidemia patient in India", Genome ...
Candidemia is a worldwide bloodstream disease mainly affecting peripheral organs in humans. Usually, candidemia caused by C. ... According to the data obtained from 2010, frequency of candidemia is 12-25% in the US, 4.5-9% in Europe, 20-24% in Brazil and ... gastrointestinal candidiasis and candidemia. C. tropicalis colonization is favoured in the gastrointestinal tract; a common ...
"Emergence of Candida parapsilosis as the Predominant Species Causing Candidemia in Children". Clinical Infectious Diseases. 26 ...
This species has been associated with candidemia and has been recovered from catheters. It has also found in biofilms on other ...
... is indicated for the treatment of candidemia, acute disseminated candidiasis, Candida peritonitis, abscesses and ... is an echinocandin antifungal drug used to treat and prevent invasive fungal infections including candidemia, abscesses and ... "Micafungin versus caspofungin for treatment of candidemia and other forms of invasive candidiasis". Clinical Infectious ...
Although Candida albicans is the most common cause of candidemia, there has been a decrease in the incidence and an increases ... Rentz, A. M.; Halpern, M. T.; Bowden, R (1998). "The impact of candidemia on length of hospital stay, outcome, and overall cost ... Weinberger, M (2016-04-16). "Characteristics of candidaemia with Candida-albicans compared with non-albicans Candida species ... a Candida albicans Protein Microarray Reveals Permanent Host-Pathogen Interplay and Stage-Specific Responses during Candidemia ...
This would cause a much more serious health condition, a state called candidemia.[7] [8] ...
Candidemia and other forms of invasive Candida infections (intra-abdominal abscess and peritonitis) Esophageal candidiasis ... Vicuron Pharmaceuticals Files New Drug Application (NDA) for Anidulafungin for Treatment of Invasive Candidiasis/Candidemia ... dose-ranging study evaluating the safety and efficacy of anidulafungin in invasive candidiasis and candidemia". Antimicrob ...
ISBN 978-1-55581-539-4. Weinberger, M (2016-04-16). "Characteristics of candidaemia with Candida-albicans compared with non- ...
... candidemia). Yeasts are able to grow in foods with a low pH (5.0 or lower) and in the presence of sugars, organic acids, and ...
However, there has been a marked increase in the number of recognized cases of candidemia due to this organism in the last two ...
... comparison of results from a reference centre and from a population-based surveillance study of candidemia". Medical Mycology: ...
Candidemia). It is especially prevalent in the elderly and HIV positive people. There are two widely cited potential virulence ...
Systemic infections of the bloodstream and major organs (candidemia or invasive candidiasis), particularly in immunocompromised ... candidemia). Yet, there is an increasing incidence of infections caused by C. glabrata and C. rugosa, which could be because ...
... a fungemia called candidemia. Symptoms of esophageal candidiasis include difficulty swallowing, painful swallowing, abdominal ...
... the FDA approval includes indication for the treatment of candidemia and some specific Candida infections (intra-abdominal ...
... candidemia).[113] ...
... candidemia).[116] ...
... candidemia).[107] ...
C. glabrata represents the second most prevalent cause of candidemia and a better understanding of its virulence and drug ... C. glabrata represents the second most prevalent cause of candidemia and a better understanding of its virulence and drug ...
Endophthalmitis is a relatively frequent complication of candidemia and less commonly occurs in patients who have invasive ...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
The rate of candidemia increased in Finland but is still substantially lower than in the United States. No shift to non-C. ... A total of 79 cases of candidemia were identified at the hospital; the rate varied from 0.03 to 0.05 per 1,000 patient-days by ... Candidemia in Finland, 1995-1999.. Poikonen E1, Lyytikäinen O, Anttila VJ, Ruutu P. ... A total of 479 candidemia cases were reported to the Register. The annual incidence rose from 1.7 per 100,000 population in ...
Pfizer is currently recruiting for the NCT00548262 Candidemia, Invasive Candidiasis Cancer trial. Review trial description, ... For The Treatment Of Candidemia And Invasive Candidiasis. Back to Search Print Save as PDF Bookmark Trial ... Presence of candidemia (positive blood culture) or invasive candidiasis. (histopathologic or cytopathologic examination of a ... Presence of candidemia (positive blood culture) or invasive candidiasis (histopathologic or cytopathologic examination of a ...
... or micafungin is the treatment of choice for critically ill patients with candidemia. ... Voriconazole is effective for the treatment of candidemia, but it offers little advantage over fluconazole and is recommended ... She has multiple risk factors for candidemia, including exposure to broad-spectrum antibiotics and having received parenteral ... is the treatment of choice for critically ill patients with candidemia. ...
Candidemia is a health care-associated bloodstream infection caused by Candida yeasts, with one in four cases resulting in ... Candidemia is a health care-associated bloodstream infection caused by Candida yeasts, with one in four cases resulting in ... Problem/Condition: Candidemia is a bloodstream infection (BSI) caused by yeasts in the genus Candida. Candidemia is one of the ... Patients with candidemia identified in the surveillance program had many of the typical risk factors for candidemia, including ...
Writing in Mycoses, the researchers explained that candidemia - the most common clinical presentation of invasive candidiasis ... Researchers identified numerous clinical characteristics that predict the presence of candidemia in patients with candiduria, ... "Candiduria is a predictor for candidemia; however, patient characteristics that are associated with concurrent candidemia in ... "Candiduria is a predictor for candidemia; however, patient characteristics that are associated with concurrent candidemia in ...
Micafungin Versus Fluconazole in the Treatment of Invasive Candidiasis and Candidemia. The safety and scientific validity of ... Candidemia. Candidiasis, Invasive. Mycoses. Fungemia. Sepsis. Infection. Invasive Fungal Infections. Systemic Inflammatory ... Patients with a confirmed diagnosis of candidemia and invasive candidiasis. *Patients could be newly diagnosed with candidiasis ... invasive candidiasis and candidemia) to determine its efficacy and safety. Patients, both male and female, aged over 16 and ...
Candida dubliniensis candidemia in patients with chemotherapy-induced neutropenia and bone marrow transplantation. Emerg Infect ... Marriott, D., Laxton, M., & Harkness, J. (2001). Candida dubliniensis Candidemia in Australia. Emerging Infectious Diseases, 7( ... There was no evidence of metastatic candidemia.. Positive cultures were detected at 31 hours by the BacTAlert (Organon Teknika ... Marriott D, Laxton M, Harkness J. Candida dubliniensis Candidemia in Australia. Emerging Infectious Diseases. 2001;7(3):479. ...
Candidemia associated Septic Shock. GOURANG PATEL, PhD, CHRISTOPHER CRANK, PhD, LAURIE PROIA, MD, DAVID SIMON, MD, PhD; ... The aim of this study was to evaluate antifungal therapy and mortality in patients with candidemia and septic shock. Methods: ... The empiric addition of antifungal therapy for patients with septic shock may be considered in those at risk for candidemia. ... Patient demographics, severity of illness (APACHE II), risk factors for candidemia, antibiotic therapy, species of Candida, and ...
1) and report Candida auris as a causative agent of candidemia in South Africa, with an estimated prevalence of 0.3% (N.P. ... Candida auris-Associated Candidemia, South Africa. Emerging Infectious Diseases. 2014;20(7):1250-1251. doi:10.3201/ ... Magobo, R. E., Corcoran, C., Seetharam, S., & Govender, N. P. (2014). Candida auris-Associated Candidemia, South Africa. ... Identification and antifungal susceptibility results of 4 Candida auris isolates from 4 male patients with candidemia, South ...
BIOPIC: Fungal Biomarkers for Diagnosis and Response to Therapy for Pediatric Candidemia (BIOPIC). The safety and scientific ...
An episode of candidemia was defined as at least one blood culture positive for Candida. Episodes of candidemia in a single ... During the period 1991 to 2003 a total of 1,393 episodes of candidemia occurred in 1,348 patients. The incidence of candidemia ... It is also important to elucidate the reason why some patients have recurrent candidemia and the increase in candidemia ... Candidemia in Norway (1991 to 2003): Results from a Nationwide Study. Per Sandven, Lars Bevanger, Asbjørn Digranes, Hanne H. ...
The purpose of the study is to evaluate the safety and efficacy of FK463 in the treatment of patients with confirmed candidemia ... this episode of candidemia or invasive candidiasis for more than 48 hours prior to. the first dose of FK463; or efficacy ... An Open-Label, Non-Comparative Study of FK463 in the Treatment of Candidemia or Invasive Candidiasis. Trial Phase:. Phase 2. ... Has Candidemia or invasive candidiasis documented by typical clinical signs and. symptoms and confirmed by fungal culture or ...
Increasing Incidence of Candidemia: Results from a 20-Year Nationwide Study in Iceland. Lena Rós Ásmundsdóttir, Helga ... Candidemia in a tertiary care hospital: epidemiology, risk factors, and predictors of mortality. Clin. Infect. Dis.15:414-421. ... Candidemia at selected Canadian sites: results from the Fungal Disease Registry, 1992-1994. Can. Med. Assoc. J.160:493-499. ... Candidaemia in an Australian teaching hospital: relationship to central line and TPN use. J. Infect.36:203-207. ...
Study Will Evaluate The Safety And Efficacy Of Anidulafungin In Patients With Candidemia Or Invasive Candidiasis. The safety ... Candidemia. Candidiasis, Invasive. Mycoses. Fungemia. Sepsis. Infection. Invasive Fungal Infections. Systemic Inflammatory ... Phase IV Open Label Non Comparative Trial Of IV Anidulafungin Followed By Oral Azole Therapy For The Treatment Of Candidemia ... Presence of candidemia (positive blood culture) or invasive candidiasis (histopathologic or cytopathologic examination of a ...
... candidaemia explanation free. What is candidaemia? Meaning of candidaemia medical term. What does candidaemia mean? ... Looking for online definition of candidaemia in the Medical Dictionary? ... candidemia. (redirected from candidaemia) candidemia. [kan″dĭ-de´me-ah] the presence in the blood of fungi of the genus Candida ... Candidaemia , definition of candidaemia by Medical dictionary https://medical-dictionary.thefreedictionary.com/candidaemia ...
... of all culture-confirmed candidemia patients over a 31-month period at seven major hospitals) to identify patient-to-patient ... of all culture-confirmed candidemia patients over a 31-month period at seven major hospitals) to identify patient-to-patient ... is a major cause of candidemia in immunocompromised individuals and hospitalized patients with other debilitating diseases. ... is a major cause of candidemia in immunocompromised individuals and hospitalized patients with other debilitating diseases. ...
Epidemiology of Candidemia.) Chow, JK, Golan, Y, Ruthazer, R. "Risk factors for albicans and non-albicans candidemia in the ... 1. Candidemia. While any organism can be a contaminant in a blood culture, isolation of candida from blood cultures should be ... Candidemia. Fluconazole 400 mg/d x 14 daysCaspofungin 70 mg load x1, then 50 mg/d x 14 daysAnidulafungin 200 mg load x1, then ... Risk factors for candidemia.) Blumberg, HM, Jarvis, WR, Soucie, JM. "Risk factors for candidal bloodstream infections in ...
Epidemiology of candidaemia and invasive candidiasis: a changing face. Rev Iberoam Micol 31:42-48. doi:10.1016/j.riam.2013.10. ... Compared to a matched cohort of hospitalized patients without candidemia, hospitalized adult patients with candidemia incurred ... A Risk Score for Fluconazole Failure among Patients with Candidemia. Luis Ostrosky-Zeichner, Rachel Harrington, Nkechi Azie, ... A Risk Score for Fluconazole Failure among Patients with Candidemia. Luis Ostrosky-Zeichner, Rachel Harrington, Nkechi Azie, ...
Reduced Candida glabrata Susceptibility Secondary to an FKS1 Mutation Developed during Candidemia Treatment. John D. Cleary, ... Reduced Candida glabrata Susceptibility Secondary to an FKS1 Mutation Developed during Candidemia Treatment ... Reduced Candida glabrata Susceptibility Secondary to an FKS1 Mutation Developed during Candidemia Treatment ... Reduced Candida glabrata Susceptibility Secondary to an FKS1 Mutation Developed during Candidemia Treatment ...
Statin-users had candidemia as a cause of their systemic inflammatory response and were on statins throughout their antifungal ... In our small, single-center matched-cohort study, statins may provide a survival benefit in candidemia, however further studies ... This retrospective matched- cohort study from 1/2003 to 12/2006 evaluated the effects of statins on patients with candidemia ... There were no differences in duration of candidemia, antifungal therapy or Candida species between the groups. Statins were ...
... to evaluate the clinical characteristics and to ascertain the variables related to the onset and the outcome of candidemia. The ... A retrospective study of 76 episodes of candidemia in 73 patients with underlying hematological malignancy, from 1988 until ... Seventeen candidemias developed during azoles prophylaxis. One month after the diagnosis of candidemia, 26 patients died. In 19 ... before the candidemia diagnosis for a median time of 13 d, and in 53 episodes (70%) at microbiological diagnosis of candidemia ...
  • CDC's Emerging Infections Program (EIP), a collaboration among CDC, state health departments, and academic partners that was established in 1995, was used to conduct active, population-based laboratory surveillance for candidemia in 22 counties in four states (Georgia, Maryland, Oregon, and Tennessee) with a combined population of approximately 8 million persons. (cdc.gov)
  • Population-based surveillance for candidemia in Australia from 2001 to 2004 identified 1,095 cases. (cdc.gov)
  • The Australian Candidemia Study Group was formed in 2001 to conduct the first countrywide, population-based, active laboratory surveillance for candidemia. (cdc.gov)
  • Of the 62 episodes of neonatal candidemia in a Children's Hospital between January 1994 and July 1998, 38 stocked isolates from 38 infants' bloodstreams were available and underwent antifungal susceptibility test according to National Committee for Clinical Laboratory Standards M27-A document. (elsevier.com)
  • Continued surveillance will be important to monitor the epidemiology of candidemia and to detect emergence of resistance to azoles. (oup.com)
  • The aim of our study was to estimate epidemiology of candidemia in large HSCT recipients' cohort for the 10-year period transplant activity in R. Gorbacheva Memorial Institute of Children Oncology, Hematology and Transplantation of First Pavlov State Medical University of St. Petersburg. (cttjournal.com)
  • The main objective of this study was to evaluate changes in the epidemiology of candidemia at a tertiary care hospital in a 21-year period. (bjid.org.br)
  • Identifying the susceptibility pathways will aid the development of new therapies for candidemia. (rug.nl)
  • Elevated heart rate, temperature and creatinine and the presence of neutropenia and neutrophilia also were associated with candidemia. (healio.com)
  • Our patient also had advanced liver disease but had few other recognizable risk factors for candidemia, with transient neutropenia and a short course of broad-spectrum antimicrobial therapy the only apparent predisposing factors. (cdc.gov)
  • p=0.004), antimycotic prophylaxis (p=0.01), presence of central venous catheter (p=0.01), neutropenia (p=0.002), and the use of glycopeptide (p=0.0001) increased the risk of candidemia. (nih.gov)
  • Multivariate analysis revealed that intensive care unit stay, neutropenia, use of corticosteroids, and duration of neutropenia as significant risk factors for BT candidemia. (aspergillus.org.uk)
  • Neutrophil recovery was defined as the resolution of neutropenia beyond 0.5×10 9 /L. Mortality resulting from candidemia was defined as death within 30 days after the initial blood culture under the condition of stable haematological disease and none of the possible reasons for death. (mjhid.org)
  • Most isolates from the bloodstreams of neonates with candidemia were susceptible to antifungal agents tested but a low MIC of the antifungal agent did not predict successful therapy in this study. (elsevier.com)
  • The median time from admission to candidemia diagnosis was 5 days (interquartile range [IQR]: 0-16 days). (cdc.gov)
  • The age at onset of candidemia ranged from 15 to 173 days with a median of 34 days. (ntu.edu.tw)
  • The median term for candidemia registration was 109 days after allo-HSCT (range, 3 to 1337) versus 20 days after auto-HSCT (range, 8-33). (cttjournal.com)
  • 5.3% of candidaemia cases), as compared with C. albicans candidaemia, was significantly more likely to be outpatient-acquired than inpatient-acquired (15 of 57 vs. 65 of 517 episodes, p 0.01). (edu.au)
  • Presence of sepsis at diagnosis and crude 30-day mortality rates were similar for C. dubliniensis-related, non-C. dubliniensis-related and C. albicans-related candidaemia. (edu.au)
  • We analyzed laboratory-based surveillance candidemia data from the National Infectious Disease Register in Finland and reviewed cases of candidemia from one tertiary-care hospital from 1995 to 1999. (nih.gov)
  • We evaluated all episodes of candidemia diagnosed between 1996 and 2016 at a University-affiliated tertiary care hospital in Brazil. (bjid.org.br)
  • In our small, single-center matched-cohort study, statins may provide a survival benefit in candidemia, however further studies are warranted to validate and further explore this association. (biomedcentral.com)
  • This was a monocentric, retrospective cohort study of candidemia. (ivteam.com)
  • In the validation cohort, the rates of candidemia were similar through the risk factor stratification groups. (biomedcentral.com)
  • Vascular catheters are considered the likely culprit for the sudden emergence of hospital-acquired candidemia. (ivteam.com)
  • An intravenous echinocandin such as anidulafungin , caspofungin or micafungin is recommended as first-line therapy for fungemia, specifically candidemia. (wikipedia.org)
  • In this review we have analyzed the available literature pertaining to the total duration of intravenous (IV) therapy and the appropriate timing of step down to oral therapy in the management of candidemia. (mjhid.org)
  • In 19 cases, death was attributable to candidemia. (nih.gov)
  • The potential risk factors and attributable mortality of persistent candidemia in VLBW infants in Western China are unknown. (biomedcentral.com)
  • Death rates associated with candidemia are high (40%-70%) ( 3 ), with an estimated attributable death rate of 25% to 49% ( 4 , 5 ). (cdc.gov)
  • Candidemia in Finland, 1995-1999. (nih.gov)
  • A nationwide study on candidemia was conducted in Iceland from 1980 to 1999. (asm.org)
  • We reviewed 62 episodes (from 59 infants) of neonatal candidemia that occurred between January 1994 and June 1999. (ntu.edu.tw)
  • The rate of candidemia increased in Finland but is still substantially lower than in the United States. (nih.gov)
  • Statin-users included were at least 45 years old, taking a statin (simvastatin, atorvastatin, or pravastatin) present in any medical or surgical ICU at the onset of candidemia. (biomedcentral.com)
  • These data document the substantial burden of candidemia and its changing epidemiology. (oup.com)
  • CONCLUSIONS: The epidemiology and choice of therapy for candidemia are rapidly changing. (jefferson.edu)
  • Efforts to enhance rates of appropriate therapy for candidemia may improve resource use. (springer.com)