A form of invasive candidiasis where species of CANDIDA are present in the blood.
The presence of fungi circulating in the blood. Opportunistic fungal sepsis is seen most often in immunosuppressed patients with severe neutropenia or in postoperative patients with intravenous catheters and usually follows prolonged antibiotic therapy.
Infection with a fungus of the genus CANDIDA. It is usually a superficial infection of the moist areas of the body and is generally caused by CANDIDA ALBICANS. (Dorland, 27th ed)
A genus of yeast-like mitosporic Saccharomycetales fungi characterized by producing yeast cells, mycelia, pseudomycelia, and blastophores. It is commonly part of the normal flora of the skin, mouth, intestinal tract, and vagina, but can cause a variety of infections, including CANDIDIASIS; ONYCHOMYCOSIS; vulvovaginal candidiasis (CANDIDIASIS, VULVOVAGINAL), and thrush (see CANDIDIASIS, ORAL). (From Dorland, 28th ed)
Substances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues.
Triazole antifungal agent that is used to treat oropharyngeal CANDIDIASIS and cryptococcal MENINGITIS in AIDS.
An important nosocomial fungal infection with species of the genus CANDIDA, most frequently CANDIDA ALBICANS. Invasive candidiasis occurs when candidiasis goes beyond a superficial infection and manifests as CANDIDEMIA, deep tissue infection, or disseminated disease with deep organ involvement.
The ability of fungi to resist or to become tolerant to chemotherapeutic agents, antifungal agents, or antibiotics. This resistance may be acquired through gene mutation.
A species of MITOSPORIC FUNGI commonly found on the body surface. It causes opportunistic infections especially in immunocompromised patients.
Cyclic hexapeptides of proline-ornithine-threonine-proline-threonine-serine. The cyclization with a single non-peptide bond can lead them to be incorrectly called DEPSIPEPTIDES, but the echinocandins lack ester links. Antifungal activity is via inhibition of 1,3-beta-glucan synthase production of BETA-GLUCANS.
Macrolide antifungal antibiotic produced by Streptomyces nodosus obtained from soil of the Orinoco river region of Venezuela.
A species of MITOSPORIC FUNGI that is a major cause of SEPTICEMIA and disseminated CANDIDIASIS, especially in patients with LYMPHOMA; LEUKEMIA; and DIABETES MELLITUS. It is also found as part of the normal human mucocutaneous flora.
Any infection which a patient contracts in a health-care institution.
A unicellular budding fungus which is the principal pathogenic species causing CANDIDIASIS (moniliasis).
Placement of an intravenous CATHETER in the subclavian, jugular, or other central vein.
Substances of fungal origin that have antigenic activity.
The study of the structure, growth, function, genetics, and reproduction of fungi, and MYCOSES.
Care of a highly technical and specialized nature, provided in a medical center, usually one affiliated with a university, for patients with unusually severe, complex, or uncommon health problems.
Glucose polymers consisting of a backbone of beta(1->3)-linked beta-D-glucopyranosyl units with beta(1->6) linked side chains of various lengths. They are a major component of the CELL WALL of organisms and of soluble DIETARY FIBER.
The body fluid that circulates in the vascular system (BLOOD VESSELS). Whole blood includes PLASMA and BLOOD CELLS.
A decrease in the number of NEUTROPHILS found in the blood.
Polysaccharides consisting of mannose units.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Compounds consisting of a short peptide chain conjugated with an acyl chain.
Immunoglobulins produced in a response to FUNGAL ANTIGENS.
The number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from PREVALENCE, which refers to all cases, new or old, in the population at a given time.
Hospital units providing continuous surveillance and care to acutely ill patients.
Infection by a variety of fungi, usually through four possible mechanisms: superficial infection producing conjunctivitis, keratitis, or lacrimal obstruction; extension of infection from neighboring structures - skin, paranasal sinuses, nasopharynx; direct introduction during surgery or accidental penetrating trauma; or via the blood or lymphatic routes in patients with underlying mycoses.
Hospital units providing continuing surveillance and care to acutely ill newborn infants.
Candidiasis of the skin manifested as eczema-like lesions of the interdigital spaces, perleche, or chronic paronychia. (Dorland, 27th ed)
Catheters designed to be left within an organ or passage for an extended period of time.
An infant during the first month after birth.
Procedures for identifying types and strains of fungi.
Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses).
An acronym for Acute Physiology and Chronic Health Evaluation, a scoring system using routinely collected data and providing an accurate, objective description for a broad range of intensive care unit admissions, measuring severity of illness in critically ill patients.
A medical facility which provides a high degree of subspecialty expertise for patients from centers where they received SECONDARY CARE.
Infections resulting from the use of catheters. Proper aseptic technique, site of catheter placement, material composition, and virulence of the organism are all factors that can influence possible infection.
The ability of fungi to resist or to become tolerant to several structurally and functionally distinct drugs simultaneously. This resistance phenotype may be attributed to multiple gene mutations.
Suppurative inflammation of the tissues of the internal structures of the eye frequently associated with an infection.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
A triazole antifungal agent that inhibits cytochrome P-450-dependent enzymes required for ERGOSTEROL synthesis.
An infection caused by an organism which becomes pathogenic under certain conditions, e.g., during immunosuppression.
Institutions with an organized medical staff which provide medical care to patients.
Neoplasms located in the blood and blood-forming tissue (the bone marrow and lymphatic tissue). The commonest forms are the various types of LEUKEMIA, of LYMPHOMA, and of the progressive, life-threatening forms of the MYELODYSPLASTIC SYNDROMES.
Deoxyribonucleic acid that makes up the genetic material of fungi.
A method where a culturing surface inoculated with microbe is exposed to small disks containing known amounts of a chemical agent resulting in a zone of inhibition (usually in millimeters) of growth of the microbe corresponding to the susceptibility of the strain to the agent.
A technique using antibodies for identifying or quantifying a substance. Usually the substance being studied serves as antigen both in antibody production and in measurement of antibody by the test substance.

Incidence and predictors of invasive candidiasis associated with candidaemia in children. (1/130)

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Comparison of albicans vs. non-albicans candidemia in French intensive care units. (2/130)

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Relative frequency of albicans and the various non-albicans Candida spp among candidemia isolates from inpatients in various parts of the world: a systematic review. (3/130)

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Candida albicans heme oxygenase and its product CO contribute to pathogenesis of candidemia and alter systemic chemokine and cytokine expression. (4/130)

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Analysis of Candida glabrata strains with reduced sensitivity to micafungin in vitro isolated from a patient with persistent Candidemia. (5/130)

We report the appearance of Candida glabrata strains with reduced sensitivity during treatment with the echinocandin drug micafungin (MCF). Four C. glabrata strains were isolated from sputum, gastric juice, and blood taken from a patient during hospitalization. Two of these strains, one of which was obtained after treatment with MCF for suspected Candida pneumonia and the other of which was obtained during MCF treatment for candidemia, were isolated from blood and found to have a reduced susceptibility to MCF. These two clinical isolates showed a high minimum inhibitory concentration (MIC) for MCF, with this change in MIC being unique for MCF among established antifungal drugs. To further investigate the mechanism underlying this reduced sensitivity, an in vivo mouse infection model and in vitro enzymatic analysis were performed. MCF had little effect in the mouse disseminated infection model and enzymatic analysis showed the low affinity of MCF to the 1,3-Beta-D-glucan synthase of the clinical isolates, although the enzymes of both clinical isolates and control strain were noncompetitively inhibited by MCF. Taken together, this low affinity of MCF for the enzymes is likely to cause the reduced sensitivities. These data further indicate that MCF could induce acquired MCF-resistant strains during clinical use.  (+info)

Recent exposure to caspofungin or fluconazole influences the epidemiology of candidemia: a prospective multicenter study involving 2,441 patients. (6/130)

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Candida bloodstream infections: comparison of species distributions and antifungal resistance patterns in community-onset and nosocomial isolates in the SENTRY Antimicrobial Surveillance Program, 2008-2009. (7/130)

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Candidemia after cardiac surgery in the intensive care unit: an observational study. (8/130)

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Candidemia can cause a range of symptoms, including fever, chills, rapid heart rate, and confusion. In severe cases, it can lead to organ failure and death. Treatment typically involves the use of antifungal medications, and in some cases, hospitalization is necessary to manage the infection and monitor the patient's condition.

Preventative measures to reduce the risk of developing candidemia include proper handwashing and hygiene, avoiding close contact with people who are sick, and ensuring that medical equipment and surfaces are properly cleaned and disinfected. Early detection and treatment can significantly improve outcomes for patients with candidemia.

Symptoms of fungemia may include fever, chills, night sweats, fatigue, and weight loss. Diagnosis is typically made by drawing blood cultures and performing microbiological tests to identify the presence of fungal organisms in the blood. Treatment typically involves administration of antifungal medications, which can be given intravenously or orally. In severe cases, hospitalization may be necessary to monitor and treat the condition.

In some cases, fungemia can lead to complications such as sepsis, organ failure, and death. Prompt diagnosis and treatment are essential to prevent these outcomes.

Types of candidiasis:

1. Vulvovaginal candidiasis (VVC): a common infection that affects the vagina and vulva; symptoms include itching, burning, and abnormal discharge.
2. Oral thrush (OT): an infection that affects the mouth, often seen in infants and people with weakened immune systems; symptoms include white patches on the tongue and inside the cheeks.
3. Invasive candidiasis (IC): a severe infection that can spread throughout the body, often seen in people with weakened immune systems, such as those with HIV/AIDS or undergoing chemotherapy; symptoms include fever, chills, and difficulty breathing.
4. Candidal balanitis: an infection of the foreskin and glans of the penis; symptoms include redness, swelling, and pain.
5. Diaper rash: a common skin infection that affects infants who wear diapers; symptoms include redness, swelling, and irritability.

Causes and risk factors:

1. Overgrowth of Candida fungus due to an imbalance of the normal flora.
2. Use of antibiotics or steroids that can disrupt the balance of the body's natural flora.
3. Weakened immune system, such as in people with HIV/AIDS or undergoing chemotherapy.
4. Poor hygiene and sanitation.
5. Diabetes mellitus.
6. Pregnancy.
7. Obesity.

Diagnosis:

1. Physical examination and medical history.
2. Microscopic examination of a scraping or biopsy specimen.
3. Cultures of skin, blood, or other body fluids.
4. Polymerase chain reaction (PCR) or other molecular diagnostic techniques to detect the presence of the fungus.

Treatment:

1. Topical antifungal medications, such as clotrimazole, miconazole, or terbinafine, applied directly to the affected area.
2. Oral antifungal medications, such as fluconazole or itraconazole, for more severe infections or those that do not respond to topical treatment.
3. Antibiotics if there is a secondary bacterial infection.
4. Supportive care, such as pain management and wound care.
5. Proper hygiene and sanitation practices.
6. In severe cases, hospitalization may be necessary for intravenous antifungal medications and close monitoring.

Prevention:

1. Practice good hygiene and sanitation.
2. Avoid sharing personal items, such as towels or clothing.
3. Wash hands before touching the affected area.
4. Keep the affected area clean and dry.
5. Use of antifungal powders or sprays on the affected area.
6. Avoid using harsh soaps or cleansers that can irritate the skin.
7. Wear shoes in public areas to prevent exposure to fungal spores.
8. Avoid sharing bathing or showering facilities with others.
9. Dry thoroughly after bathing or swimming.
10. Use of antifungal medications as a prophylactic measure in high-risk individuals, such as those with weakened immune systems.

It's important to note that the best treatment and prevention strategies will depend on the specific type of fungus causing the infection, as well as the severity and location of the infection. It is essential to consult a healthcare professional for proper diagnosis and treatment.

Candidiasis, invasive is caused by the overgrowth of Candida in the body, which can occur for a variety of reasons, such as:

* Weakened immune system due to HIV/AIDS, cancer, or medications that suppress the immune system.
* Invasive medical devices, such as central lines or implanted pacemakers.
* Previous history of invasive candidiasis.
* Pregnancy.
* Intravenous drug use.

The symptoms of candidiasis, invasive can vary depending on the organs affected, but may include:

* Fever.
* Chills.
* Shortness of breath.
* Pain in the abdomen or chest.
* Confusion or disorientation.
* Skin rash or lesions.

Diagnosis of candidiasis, invasive is based on a combination of physical examination, medical history, and laboratory tests, such as blood cultures and imaging studies. Treatment typically involves the use of antifungal medications, which may be given intravenously or orally, depending on the severity of the infection. In severe cases, hospitalization may be necessary to monitor and treat the infection.

Prevention of candidiasis, invasive includes:

* Proper hygiene and handwashing practices.
* Avoiding close contact with individuals who have invasive candidiasis.
* Avoiding sharing of personal items, such as toothbrushes or razors.
* Avoiding the use of invasive medical devices, if possible.
* Proper care and maintenance of medical devices.
* Monitoring for signs of infection in individuals with weakened immune systems.

In conclusion, candidiasis, invasive is a serious and potentially life-threatening fungal infection that can affect various organs and systems in the body. Early diagnosis and treatment are crucial to prevent complications and improve outcomes. Proper prevention and control measures can help reduce the risk of developing invasive candidiasis.

In medicine, cross-infection refers to the transmission of an infectious agent from one individual or source to another, often through direct contact or indirect exposure. This type of transmission can occur in various settings, such as hospitals, clinics, and long-term care facilities, where patients with compromised immune systems are more susceptible to infection.

Cross-infection can occur through a variety of means, including:

1. Person-to-person contact: Direct contact with an infected individual, such as touching, hugging, or shaking hands.
2. Contaminated surfaces and objects: Touching contaminated surfaces or objects that have been touched by an infected individual, such as doorknobs, furniture, or medical equipment.
3. Airborne transmission: Inhaling droplets or aerosolized particles that contain the infectious agent, such as during coughing or sneezing.
4. Contaminated food and water: Consuming food or drinks that have been handled by an infected individual or contaminated with the infectious agent.
5. Insect vectors: Mosquitoes, ticks, or other insects can transmit infections through their bites.

Cross-infection is a significant concern in healthcare settings, as it can lead to outbreaks of nosocomial infections (infections acquired in hospitals) and can spread rapidly among patients, healthcare workers, and visitors. To prevent cross-infection, healthcare providers use strict infection control measures, such as wearing personal protective equipment (PPE), thoroughly cleaning and disinfecting surfaces, and implementing isolation precautions for infected individuals.

In summary, cross-infection refers to the transmission of an infectious agent from one individual or source to another, often through direct contact or indirect exposure in healthcare settings. Preventing cross-infection is essential to maintaining a safe and healthy environment for patients, healthcare workers, and visitors.

Symptoms of neutropenia may include recurring infections, fever, fatigue, weight loss, and swollen lymph nodes. The diagnosis is typically made through a blood test that measures the number of neutrophils in the blood.

Treatment options for neutropenia depend on the underlying cause but may include antibiotics, supportive care to manage symptoms, and in severe cases, bone marrow transplantation or granulocyte-colony stimulating factor (G-CSF) therapy to increase neutrophil production.

There are several types of fungal eye infections, including:

1. Aspergillosis: This is a common type of fungal infection that affects the eye. It is caused by the fungus Aspergillus and can occur in people with weakened immune systems or pre-existing eye conditions.
2. Candidemia: This is another common type of fungal infection that affects the eye. It is caused by the fungus Candida and can occur in people with weakened immune systems or pre-existing eye conditions.
3. Cryptococcosis: This is a rare type of fungal infection that affects the eye. It is caused by the fungus Cryptococcus and can occur in people with weakened immune systems, such as those with HIV/AIDS.
4. Histoplasmosis: This is a rare type of fungal infection that affects the eye. It is caused by the fungus Histoplasma and can occur in people who have been exposed to the fungus in soil or bird droppings.
5. Blastomycosis: This is a rare type of fungal infection that affects the eye. It is caused by the fungus Blastomyces and can occur in people who have been exposed to the fungus in soil or water.

Fungal eye infections can cause a range of symptoms, including redness, discharge, pain, and vision loss. Treatment typically involves antifungal medication and may also include surgery to remove any infected tissue. In severe cases, fungal eye infections can lead to blindness if left untreated.

Prevention measures for fungal eye infections include good hygiene practices, such as washing hands regularly and avoiding close contact with people who have the infection. People with weakened immune systems should also avoid exposure to fungi by avoiding outdoor activities during peak fungal growth seasons and wearing protective clothing when working or playing in areas where fungi are likely to be present.

Overall, fungal eye infections are uncommon but can be serious conditions that require prompt medical attention. If you suspect you may have a fungal eye infection, it is important to seek medical care as soon as possible to receive proper diagnosis and treatment.

The symptoms of candidiasis, cutaneous may include:

* Redness and swelling on the affected area
* Itching and burning sensation
* Thickening and discoloration of the skin
* Cracks or fissures in the skin

Candidiasis, cutaneous can be diagnosed through a physical examination and may require additional tests such as a skin scraping or biopsy to confirm the diagnosis. Treatment typically involves antifungal medications and good wound care. In severe cases, hospitalization may be required.

Prevention is key in avoiding candidiasis, cutaneous. Good hygiene practices such as frequent handwashing, keeping the skin clean and dry, and avoiding sharing personal items can help reduce the risk of infection. Additionally, managing underlying conditions such as diabetes and taking antibiotics only when necessary can also help prevent candidiasis, cutaneous.

The most common types of mycoses include:

1. Ringworm: This is a common fungal infection that causes a ring-shaped rash on the skin. It can affect any part of the body, including the arms, legs, torso, and face.
2. Athlete's foot: This is a common fungal infection that affects the feet, causing itching, redness, and cracking of the skin.
3. Jock itch: This is a fungal infection that affects the groin area and inner thighs, causing itching, redness, and cracking of the skin.
4. Candidiasis: This is a fungal infection caused by Candida, a type of yeast. It can affect various parts of the body, including the mouth, throat, and vagina.
5. Aspergillosis: This is a serious fungal infection that can affect various parts of the body, including the lungs, sinuses, and brain.

Symptoms of mycoses can vary depending on the type of infection and the severity of the infection. Common symptoms include itching, redness, swelling, and cracking of the skin. Treatment for mycoses usually involves antifungal medications, which can be applied topically or taken orally. In severe cases, hospitalization may be necessary to monitor and treat the infection.

Preventive measures for mycoses include practicing good hygiene, avoiding sharing personal items such as towels and clothing, and using antifungal medications as prescribed by a healthcare professional. Early diagnosis and treatment of mycoses can help prevent complications and reduce the risk of transmission to others.

The most common types of CRIs include:

1. Urinary tract infections (UTIs): These occur when bacteria enter the urinary tract through the catheter and cause an infection in the bladder, kidneys, or ureters.
2. Catheter-associated asymptomatic bacteriuria (CAB): This occurs when bacteria are present in the urine but do not cause symptoms.
3. Catheter-associated symptomatic urinary tract infections (CAUTI): These occur when bacteria cause symptoms such as burning during urination, frequent urination, or cloudy urine.
4. Pyelonephritis: This is a type of UTI that affects the kidneys and can be life-threatening if left untreated.
5. Septicemia: This occurs when bacteria enter the bloodstream through the catheter and cause a systemic infection.
6. Catheter-related bloodstream infections (CRBSIs): These occur when bacteria enter the bloodstream through the catheter and cause an infection.
7. Catheter-associated fungal infections: These occur when fungi grow in the urinary tract or on the catheter, causing an infection.
8. Catheter-associated viral infections: These occur when a virus infects the urinary tract or the catheter.

CRIs can be prevented by using sterile equipment, proper insertion and maintenance techniques, and regularly cleaning and disinfecting the catheter. Early detection and treatment of CRIs are critical to prevent complications and improve outcomes.

Endophthalmitis can be classified into several types based on its causes, such as:

1. Postoperative endophthalmitis: This type of endophthalmitis occurs after cataract surgery or other intraocular surgeries. It is caused by bacterial infection that enters the eye through the surgical incision.
2. Endogenous endophthalmitis: This type of endophthalmitis is caused by an infection that originates within the eye, such as from a retinal detachment or uveitis.
3. Exogenous endophthalmitis: This type of endophthalmitis is caused by an infection that enters the eye from outside, such as from a penetrating injury or a foreign object in the eye.

The symptoms of endophthalmitis can include:

1. Severe pain in the eye
2. Redness and swelling of the conjunctiva
3. Difficulty seeing or blind spots in the visual field
4. Sensitivity to light
5. Increased sensitivity to touch or pressure on the eye
6. Fever and chills
7. Swollen lymph nodes
8. Enlarged pupil
9. Clouding of the vitreous humor

If you suspect that you or someone else has endophthalmitis, it is important to seek medical attention immediately. Early diagnosis and treatment can help prevent vision loss. Treatment options for endophthalmitis may include antibiotics, vitrectomy (removal of the vitreous humor), and in some cases, removal of the affected eye.

Examples of OIs include:

1. Pneumocystis pneumonia (PCP): A type of pneumonia caused by the fungus Pneumocystis jirovecii, which is commonly found in the lungs of individuals with HIV/AIDS.
2. Cryptococcosis: A fungal infection caused by Cryptococcus neoformans, which can affect various parts of the body, including the lungs, central nervous system, and skin.
3. Aspergillosis: A fungal infection caused by Aspergillus fungi, which can affect various parts of the body, including the lungs, sinuses, and brain.
4. Histoplasmosis: A fungal infection caused by Histoplasma capsulatum, which is commonly found in the soil and can cause respiratory and digestive problems.
5. Candidiasis: A fungal infection caused by Candida albicans, which can affect various parts of the body, including the skin, mouth, throat, and vagina.
6. Toxoplasmosis: A parasitic infection caused by Toxoplasma gondii, which can affect various parts of the body, including the brain, eyes, and lymph nodes.
7. Tuberculosis (TB): A bacterial infection caused by Mycobacterium tuberculosis, which primarily affects the lungs but can also affect other parts of the body.
8. Kaposi's sarcoma-associated herpesvirus (KSHV): A viral infection that can cause various types of cancer, including Kaposi's sarcoma, which is more common in individuals with compromised immunity.

The diagnosis and treatment of OIs depend on the specific type of infection and its severity. Treatment may involve antibiotics, antifungals, or other medications, as well as supportive care to manage symptoms and prevent complications. It is important for individuals with HIV/AIDS to receive prompt and appropriate treatment for OIs to help prevent the progression of their disease and improve their quality of life.

Hematologic neoplasms refer to abnormal growths or tumors that affect the blood, bone marrow, or lymphatic system. These types of cancer can originate from various cell types, including red blood cells, white blood cells, platelets, and lymphoid cells.

There are several subtypes of hematologic neoplasms, including:

1. Leukemias: Cancers of the blood-forming cells in the bone marrow, which can lead to an overproduction of immature or abnormal white blood cells, red blood cells, or platelets. Examples include acute myeloid leukemia (AML) and chronic lymphocytic leukemia (CLL).
2. Lymphomas: Cancers of the immune system, which can affect the lymph nodes, spleen, liver, or other organs. Examples include Hodgkin lymphoma and non-Hodgkin lymphoma.
3. Multiple myeloma: A cancer of the plasma cells in the bone marrow that can lead to an overproduction of abnormal plasma cells.
4. Myeloproliferative neoplasms: Cancers that affect the blood-forming cells in the bone marrow, leading to an overproduction of red blood cells, white blood cells, or platelets. Examples include polycythemia vera and essential thrombocythemia.
5. Myelodysplastic syndromes: Cancers that affect the blood-forming cells in the bone marrow, leading to an underproduction of normal blood cells.

The diagnosis of hematologic neoplasms typically involves a combination of physical examination, medical history, laboratory tests (such as complete blood counts and bone marrow biopsies), and imaging studies (such as CT scans or PET scans). Treatment options for hematologic neoplasms depend on the specific type of cancer, the severity of the disease, and the overall health of the patient. These may include chemotherapy, radiation therapy, stem cell transplantation, or targeted therapy with drugs that specifically target cancer cells.

The most common type, also known as candidemia, candedemia, or systemic candidiasis, is caused by Candida species; candidemia ... Blood cultures should be obtained in all patients with suspected candidemia. Neutropenic vs non-neutropenic candidemia is ... The gold standard for the diagnosis of invasive candidiasis and candidemia is a positive culture. ... specifically candidemia. Oral or intravenous fluconazole is an acceptable alternative. The lipid formulation amphotericin B is ...
Most had persistent candidemia and a high mortality rate was observed. All isolates were of the same clonal strain, however, ... June 2017). "Candida auris candidaemia in Indian ICUs: analysis of risk factors". The Journal of Antimicrobial Chemotherapy. 72 ... February 2015). "Incidence, characteristics and outcome of ICU-acquired candidemia in India". Intensive Care Medicine. 41 (2): ... "Draft Genome Sequence of a Fluconazole-Resistant Candida auris Strain from a Candidemia Patient in India". Genome Announcements ...
Candidemia is a worldwide bloodstream disease mainly affecting peripheral organs in humans. Usually, candidemia caused by C. ... According to the data obtained from 2010, frequency of candidemia is 12-25% in the US, 4.5-9% in Europe, 20-24% in Brazil and ... gastrointestinal candidiasis and candidemia. C. tropicalis colonization is favoured in the gastrointestinal tract; a common ...
"Emergence of Candida parapsilosis as the Predominant Species Causing Candidemia in Children". Clinical Infectious Diseases. 26 ...
This species has been associated with candidemia and has been recovered from catheters. It has also found in biofilms on other ...
October 2007). "Micafungin versus caspofungin for treatment of candidemia and other forms of invasive candidiasis". Clinical ... Micafungin is indicated for the treatment of candidemia, acute disseminated candidiasis, Candida peritonitis, abscesses and ... is an echinochandin antifungal medication used to treat and prevent invasive fungal infections including candidemia, abscesses ...
Garbino, J; Kolarova, L; Rohner, P; Lew, D; Pichna, P; Pittet, D (2002). "Secular trends of candidemia over 12 years in adult ...
Although Candida albicans is the most common cause of candidemia, there has been a decrease in the incidence and an increased ... Rentz AM, Halpern MT, Bowden R (October 1998). "The impact of candidemia on length of hospital stay, outcome, and overall cost ... October 2005). "Characteristics of candidaemia with Candida-albicans compared with non-albicans Candida species and predictors ... a Candida albicans protein microarray reveals permanent host-pathogen interplay and stage-specific responses during candidemia ...
Candidemia and other forms of invasive Candida infections (intra-abdominal abscess and peritonitis) Esophageal candidiasis ... Vicuron Pharmaceuticals Files New Drug Application (NDA) for Anidulafungin for Treatment of Invasive Candidiasis/Candidemia ... dose-ranging study evaluating the safety and efficacy of anidulafungin in invasive candidiasis and candidemia". Antimicrob ...
ISBN 978-1-55581-539-4. Weinberger, M (2016-04-16). "Characteristics of candidaemia with Candida-albicans compared with non- ...
It is being investigated for its potential to treat various fungal infections including aspergillosis, candidaemia, and ...
... candidemia). C. auris has been more recently identified. Yeasts are able to grow in foods with a low pH (5.0 or lower) and in ...
The STRIVE Trial (phase 2) showed weekly treatment with Rezafungin was safe and efficacious in the treatment of candidemia and/ ... Rezafungin versus Caspofungin in a Phase 2, Randomized, Double-Blind Study for the Treatment of Candidemia and Invasive ...
However, there has been a marked increase in the number of recognized cases of candidemia due to this organism in the last two ...
... candidaemia). This is almost always restricted to those with compromised immune systems, such as patients undergoing ...
... comparison of results from a reference centre and from a population-based surveillance study of candidemia". Medical Mycology. ...
Immunochip SNP array identifies novel genetic variants conferring susceptibility to candidemia. Nature Communic, 2014, 5:4675 ( ...
Systemic infections of the bloodstream and major organs (candidemia or invasive candidiasis), particularly in patients with an ... candidemia). Yet, there is an increasing incidence of infections caused by C. glabrata and C. rugosa, which could be because ...
Candidemia), especially prevalent in immunocompromised patients. Candida glabrata is of special relevance in nosocomial ...
... a fungemia called candidemia. Symptoms of esophageal candidiasis include difficulty swallowing, painful swallowing, abdominal ... caused by Candida Systemic candidiasis Candidemia, a form of fungemia which may lead to sepsis Invasive candidiasis ( ...
Candida oesophagitis and candidaemia. Higher minimum inhibitory concentration (MIC) of these agents has been observed against C ... the FDA approval includes indication for the treatment of candidemia and some specific Candida infections (intra-abdominal ...
... (trade name Mycograb) was a drug developed by NeuTec Pharma (a subsidiary of Novartis), intended to treat candidemia ...
The T2Dx Instrument, the T2Bacteria and T2Candida Panels have received marketing authorization from the U.S. Food and Drug Administration. All other T2 Biosystems products are considered investigational and for research use only.. T2 Biosystems®, T2MR®, T2Bacteria®, T2Candida®, and T2Dx® are registered trademarks of T2 Biosystems, Inc. "T2Biosystems" and the T2 Biosystems, Inc. logo design are registered trademarks or trademarks of T2Biosystems, Inc. All software and documentation is subject to T2 Biosystems, Inc. copyrights. All rights reserved. T2Direct Diagnostics™, T2HemoStat™, T2Plex™, T2Cauris™, T2Resistance™ and T2SARS-CoV-2™ are trademarks of T2 Biosystems, Inc.. © 2022 T2 Biosystems, Inc.. ...
Candidemia/tratamento farmacológico; Candidemia/epidemiologia; Candidemia/microbiologia; Anfotericina B; Estudos Retrospectivos ... Data on persistent candidemia (PC), a recognized complication of candidemia, are lacking in China. This study aimed to ... Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Assunto principal: Candidemia / ... Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Assunto principal: Candidemia / ...
Until this study, the pharmacokinetics (PK) of MICA in patients with confirmed invasive candidiasis (IC) or candidaemia (C) had ... Kuse, E., Demeyer, I. & Undre, N. Pharmacokinetics of micafungin in adult patients with invasive candidiasis and candidaemia. ... Pharmacokinetics of micafungin in adult patients with invasive candidiasis and candidaemia. *ER Kuse1, ...
Candida bloodstream infections (Candidemia) [PDF - 5 Pages]. *Clostridioides difficile infections [PDF - 3 Pages] ...
Neonatal candidemia and end-organ damage: A critical appraisal of the literature using meta-analytic techniques. Pediatrics. ... Neonatal candidemia and end-organ damage : A critical appraisal of the literature using meta-analytic techniques. In: ... Neonatal candidemia and end-organ damage: A critical appraisal of the literature using meta-analytic techniques. / Benjamin, ... Neonatal candidemia is an increasing cause of infant morbidity and mortality. We evaluated the current medical literature in an ...
Clostridium difficile Coinfection Among Patients With Candidemia. Clin Infect Dis. 2019 Feb 1;68(4):676-679. doi: 10.1093/cid/ ...
The incidence of candidemia is reported as 2-6.8% among VLBW infants not receiving prophylaxis. [7, 14, 16, 23, 24, 25, 26, 27 ... Splenic ultrasonography is recommended in patients with candidemia and should be performed if splenomegaly occurs or candidemia ... Risk factors for candidemia in critically ill infants: a matched case-control study. J Pediatr. 2005 Aug. 147(2):156-61. [QxMD ... In candidemia cases, clearance of blood stream infection should be documented with two or more negative blood culture results ...
These infections include candidemia, which is associated with extremely high mortality rates. ... The company plans to initiate a Phase 2 candidemia trial in the first half of 2016. ...
Candidemia, which is the bloodstream manifestation of fungal infections due to Candida, turns out in recent studies that weve ... In South Africa, in the private system, 10% of their Candidemias I think and climbing are due to C. auris. We know that there ... So, in effect, the Candidemia that we worry about and we worry about causing severe infections. So if you look here, Japan ... Next? So 75% of these isolates were from blood, so they were Candidemia. Next? Median age was 70. One case in a neonate. ...
Over a two-year period, a total of 241 cirrhotic patients (26% with a MELD score ,): 169 were affected by candidemia and 72 by ... A global mortality rate of 35.3 % was observed: 40.2% in patients with candidaemia and 23.6% in those with IAC. Multivariable ... Clinical characteristics and predictors of mortality in cirrhotic patients with candidemia and intra-abdominal candidiasis: a ... international study investigated the risk factors and the outcome of a large cohort of cirrhotic patients with candidemia and ...
Candida Infection of the Bloodstream - Candidemia (American Thoracic Society) - PDF * Candida Infections of the Mouth, Throat, ...
Clinical manifestations and diagnosis of candidemia and invasive candidiasis in adults. In: Marr, KA, ed. UpToDate. Updated May ... https://www.uptodate.com/contents/clinical-manifestations-and-diagnosis-of-candidemia-and-invasive-candidiasis-in-adults ...
3. Candidemia: New Directions for Management and Treatment. Amanda Theppote. 4. Adjunct Corticosteroid Therapy for Patients ...
Evaluation of Dosages Regimen of Fluconazole in Patients of Candidemia with Gender by PK/PD and Mote Carlo Simulation (Articles ...
Total annual hospital costs could be reduced by rapid candidemia identification. • Public Health • Apr 08 15 ... Improvements in outcomes are dependent on early identification of candidemia and timely administration of appropriate ...
Invasive fungal infections, notably candidemia, have been associated with COVID-19. The epidemiology of candidemia has ... Among 245 candidemia episodes, 156 occurred prior to the pandemic and 89 during the pandemic. Of the latter, 39 (43.8%) were ... The epidemiology of candidemia has been significantly affected by the COVID-19 pandemic at our center. Rigorous infection ... Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: Candida; Candidemia; invasive candidiasis; ...
Candidemia, which is the bloodstream manifestation of fungal infections due to Candida, turns out in recent studies that weve ... In South Africa, in the private system, 10% of their Candidemias I think and climbing are due to C. auris. We know that there ... So, in effect, the Candidemia that we worry about and we worry about causing severe infections. So if you look here, Japan ... Next? So 75% of these isolates were from blood, so they were Candidemia. Next? Median age was 70. One case in a neonate. ...
Epidemiology of candidemia in Swiss tertiary care hospitals: secular trends, 1991-2000. Clinical Infectious Diseases, 2004, 38: ... of all cases of candidaemia respectively [10]. These data indicate that non-albicans Candida spp. and their susceptibility ...
It is used to treat fungal infections including candidemia (fungal infection in the blood), candida peritonitis and abscess ( ...
Nolla-Salas J, Sitges-Serra A, León-Gil C, Martinez-Gonzalez J, León-Regidor MA, Ibanez-Lucia P, et al: Candidemia in non- ... Furthermore, in our study previous surgery is a determinant risk factor for candidemia as has been described by León et al. [12 ... to improve the candidemia prognosis, especially in those patients with patterns of increasing CAGTA titres [20]. This assay ... until now this procedure is still the gold standard for candidemia diagnosis. The reasons for the low number of positive blood ...
Gupta A, Gupta A, Varma A. Candida glabrata candidemia: An emerging threat in critically ill patients. Ind J of Crit Care Med ... Colombo RE, Vazquez J. Echinocandins for primary therapy of candidemia: Time for a Paradigm shift? Curr Fungal Infect Rep 2015; ... Guinea J. Global trends in the distribution of Candida species causing candidemia. Clin Microbiol Infect 2014;20 Suppl 6:5-10. ... Citation Information : Chakrabarti A. Candida glabrata candidemia. Indian J Crit Care Med 2015; 19 (3):138-139. ...
Candidemia in intensive care unit: epidemiology and prognostic factors Tasnime Labiedh, Latifa Mtibaa, Aicha Rebai, Zied Hajjej ...
Hemocultura e urocultura no diagnóstico de candidemia  Santin, Rosema; Mattei, Antonella Souza; Albano, Ana Paula Neuschrank; ...
Candidemia - Preferred Concept UI. M0542149. Scope note. A form of invasive candidiasis where species of CANDIDA are present in ...
Candidemia C1.703.360.150 C1.703.492.500.150 C1.703.492.625.150 Candidiasis, Invasive C1.703.492.500 Canrenoic Acid D4.808. ...
Mycamine (micafungin) is approved for candidemia, acute disseminated candidiasis, candidal peritonitis, and abscesses without ...
ISBN 9789863684879 作者/出版社 *張進祿/合記* 出版年代/版次 2023/1
  • Candida albicans and Candida parapsilosis are the two most frequent causes of candidemia in pediatric patients. (nih.gov)
  • Epidemiologic Shift in Candidemia Driven by Candida auris, South Africa, 2016-2017 1 . (nih.gov)
  • The first cases of Candida auris candidaemia in Oman. (nih.gov)
  • The present study was conducted over a period of 6 months to determine the Candida species causing candidemia in a neonatal intensive care unit and to analyse the risk factors associated with acquisition of significant fungemia. (who.int)
  • Treatment of candidemia and the following Candida infections: intra-abdominal abscesses, peritonitis and pleural space infections. (nih.gov)
  • Candidemia is a medical condition characterized by the presence of Candida species, particularly Candida albicans, in the bloodstream. (delawarenewsreporter.com)
  • Candidemia, which is the bloodstream manifestation of fungal infections due to Candida , turns out in recent studies that we've looked at are the most common if not some of the most common healthcare associated bloodstream infections in our country, in the United States. (cdc.gov)
  • The annual burden of candidaemia and Candida peritonitis is estimated at 5 421 and 1 901 cases, respectively. (who.int)
  • Performing ophthalmic examination (P = 0.002), CVC removal during the 48 hours following the candidemia (P = 0.008) and identifying the Candida spp. (preprints.org)
  • Candidemia in children is associated with high morbidity and mortality, increased length of hospital stays, and higher healthcare costs. (nih.gov)
  • Despite the lower severity of candidemia in medicine patients, their mortality turned out to be higher than in surgery or ICU patients. (units.it)
  • Epidemiology, antifungal susceptibility, risk factors, and mortality of persistent candidemia in adult patients in China: a 6-year multicenter retrospective study. (bvsalud.org)
  • Neonatal candidemia is an increasing cause of infant morbidity and mortality. (johnshopkins.edu)
  • These infections include candidemia, which is associated with extremely high mortality rates. (sdbj.com)
  • A global mortality rate of 35.3 % was observed: 40.2% in patients with candidaemia and 23.6% in those with IAC. (esicm.org)
  • Multivariable logistic regression analysis confirmed that candidaemia (OR 2.2, 95% CI 1.2-4.5) and septic shock (OR 3.2, 95% CI 1.7-6) were independent predictors of 30 day mortality. (esicm.org)
  • Mortality rate in the overall ICU population during the pandemic was 76.6%, much higher than the previously reported mortality of candidemia from previous studies at our center. (preprints.org)
  • There have been significant changes in the management of candidiasis in the last few years, particularly related to the appropriate use of echinocandins and expanded-spectrum azoles for candidemia, other forms of invasive candidiasis, and mucosal candidiasis. (medscape.com)
  • The parenteral formulation is still under investigation for the treatment of candidemia and invasive candidiasis. (medscape.com)
  • [ 46 ] Rezafungin is a long-acting echinocandin given wekly is being studied for candidemia and invasive candidiasis. (medscape.com)
  • REZZAYO approved in the US for candidemia and invasive candidiasis. (ns-healthcare.com)
  • Cidara Therapeutics and Melinta Therapeutics have received approval for REZZAYO (rezafungin for injection) from the US Food and Drug Administration (FDA) for the treatment of candidemia and invasive candidiasis. (ns-healthcare.com)
  • Cidara Therapeutics president and CEO Jeffrey Stein said: "The FDA approval of REZZAYO represents a significant milestone for Cidara, and for patients confronted with difficult-to-treat and often deadly candidemia and invasive candidiasis. (ns-healthcare.com)
  • Until this study, the pharmacokinetics (PK) of MICA in patients with confirmed invasive candidiasis (IC) or candidaemia (C) had not been studied. (biomedcentral.com)
  • CDTX ) antifungal Rezzayo (rezafungin) under priority review for treating candidemia and invasive candidiasis in adults with limited or no alternative treatment options, the company announced Wednesday. (yahoo.com)
  • Seriously ill or immunocompromised children are at increased risk of invasive fungal infections, particularly candidemia. (nih.gov)
  • For these reasons, fungal infections are often difficult to eradicate in the preterm infant and, in cases of candidemia, central venous catheter removal is critical for clearance and survival. (medscape.com)
  • Invasive fungal infections, notably candidemia, have been associated with COVID-19. (preprints.org)
  • IMSEAR at SEARO: Candidemia in neonatal intensive care unit. (who.int)
  • inclusion criteria included a cohort limited to all neonatal intensive care unit admissions or all episodes of candidemia in neonates. (johnshopkins.edu)
  • Echinocandins are the recommended drugs of choice for candidemia and invasive candiasis. (medscape.com)
  • 11. Echinocandins for candidemia. (nih.gov)
  • The Candidemia epidemiology section provides insights into the historical and current Candidemia patient pool and forecasted trends for seven individual major countries. (delawarenewsreporter.com)
  • The epidemiology of candidemia has significantly changed during the COVID-19 pandemic. (preprints.org)
  • We compared the epidemiology of candidemia during and prior to the COVID-19 pandemic. (preprints.org)
  • The epidemiology of candidemia has been significantly affected by the COVID-19 pandemic at our center. (preprints.org)
  • PURPOSE: Risk factors for nosocomial candidemia, severity of sepsis, treatment, and outcome were compared between patients admitted to medicine wards and those to surgical and intensive care units (ICUs). (units.it)
  • High-dose ascorbate with low-dose amphotericin B attenuates severity of disease in a model of the reappearance of candidemia during sepsis in the mouse. (nih.gov)
  • Fluconazole or an echinocandin is also preferred initial therapy for non-neutropenic candidemia, depending on disease severity and other characteristics. (nih.gov)
  • The guidelines recommend treatment with an echinocandin or lipid formulation of amphotericin B for most patients with neutropenic candidemia, although fluconazole is identified as an alternative for less critically ill patients without recent azole exposure. (nih.gov)
  • The Candidemia diagnosed incident population in the 7MM countries was estimated to be approximately 41,000+ cases in 2022, with the United States contributing approximately 23,000+ cases. (delawarenewsreporter.com)
  • We retrospectively collected data on patients with candidemia admitted to the American University of Beirut Medical Center between 2004 and 2022. (preprints.org)
  • Additionally, we compared the outcomes of critically ill patients with CAC to those with candidemia without COVID-19 from March 2020 till March 2022. (preprints.org)
  • Significant candidemia was seen in 14/19 (72.6%) of neonates. (who.int)
  • Among EU4 and the UK, it was observed that Spain had the highest incidence rate of Candidemia. (delawarenewsreporter.com)
  • Immunochip SNP array identifies novel genetic variants conferring susceptibility to candidaemia. (mpg.de)
  • Articles that also incorporated older patients, did not define a numerator and a denominator for at least 1 form of end-organ damage, included patients from other reports, or did not include all episodes of candidemia in the source population were excluded from the analysis. (johnshopkins.edu)
  • The medical literature concerning end-organ evaluation after episodes of neonatal candidemia is heterogeneous and consists largely of single-center retrospective studies. (johnshopkins.edu)
  • Among 245 candidemia episodes, 156 occurred prior to the pandemic and 89 during the pandemic. (preprints.org)
  • Candidemia is a life-threatening fungal infection and it can affect patients of all ages. (nih.gov)
  • The Candidemia market report provides current treatment practices, emerging drugs, the market share of the individual therapies, and the current and forecasted Candidemia market size from 2019 to 2032, segmented by seven major markets. (delawarenewsreporter.com)
  • According to DelveInsight, the Candidemia market in 7MM is expected to witness a major change in the study period 2019-2032. (delawarenewsreporter.com)
  • This section focuses on the uptake rate of the potential Candidemia drugs recently launched in the Candidemia market or expected to be launched in 2019-2032. (marketsampler.com)
  • We performed a retrospective study of adults (≥ 18 years) with candidemia diagnosed in our center in 2010-2015. (nih.gov)
  • Risk factors for candidemia may be used to identify patients suitable for empiric therapy. (nih.gov)
  • Among 302 patients with candidemia identified during the study period, 188 (62%) belonged to the elderly group. (nih.gov)
  • RESULTS: A total of 686 patients (mean age 70 ± 15 years) with candidemia were included. (units.it)
  • Host-related risk factors for candidemia were more common in medicine patients whereas healthcare-related factors in surgery/ICU patients. (units.it)
  • CONCLUSIONS: The burden of risk factors for candidemia was different between medicine patients and those in other wards. (units.it)
  • Des analyses régulières de la résistance aux antifongiques dans les centres médicaux sont fortement recommandées, car les résultats permettront une prise en charge plus efficace de la candidose systémique chez les patients immunodéprimés. (who.int)
  • We aim to identify the microbiological profile, resistance rates, and outcomes of COVID-19 associated candidemia (CAC) compared to patients with candidemia not associated with COVID-19. (preprints.org)
  • The Report also covers current Candidemia treatment practice/algorithm, market drivers, market barriers, and unmet medical needs to curate the best opportunities and assesses the underlying potential of the Candidemia market. (delawarenewsreporter.com)
  • Learn more about Candidemia treatment algorithms in different geographies, and patient journeys. (delawarenewsreporter.com)
  • Awareness of the best management of candidemia should be pursued, especially in medicine wards. (units.it)
  • Data on persistent candidemia (PC), a recognized complication of candidemia , are lacking in China . (bvsalud.org)
  • The calculated Candidemia market data are presented with relevant tables and graphs to give a clear view of the market at first sight. (delawarenewsreporter.com)
  • Symptoms of candidemia may include fever, chills, rapid heart rate, low blood pressure, and sometimes skin rashes or lesions. (delawarenewsreporter.com)
  • Logistic regression was used to identify risk factors associated with persistent candidemia . (bvsalud.org)
  • 5. Previous candidemia episode? (cdc.gov)
  • Candidemia typically occurs in individuals with weakened immune systems, such as those with HIV/AIDS, undergoing chemotherapy, or receiving immunosuppressive therapy. (delawarenewsreporter.com)
  • We evaluated the current medical literature in an effort to critique the literature and to document the reported prevalences of end-organ damage after neonatal candidemia. (johnshopkins.edu)
  • The Candidemia market outlook of the report helps to build a detailed comprehension of the historical, current, and forecasted Candidemia market trends by analyzing the impact of current Candidemia therapies on the market and unmet needs, and drivers, barriers, and demand for better technology. (delawarenewsreporter.com)
  • This part of the Candidemia market report also provides the diagnosed patient pool, trends, and assumptions. (delawarenewsreporter.com)
  • 18 months of age with culture-con- fi rmed candidemia at 29 sentinel hospitals in South da spp. (cdc.gov)
  • Candidemia in the elderly: What does it change? (nih.gov)
  • Candidemia can be reason of inflamation in surgery sicatrization healing process? (probacto.com)