A species of MITOSPORIC FUNGI that is a major cause of SEPTICEMIA and disseminated CANDIDIASIS, especially in patients with LYMPHOMA; LEUKEMIA; and DIABETES MELLITUS. It is also found as part of the normal human mucocutaneous flora.
A genus of yeast-like mitosporic Saccharomycetales fungi characterized by producing yeast cells, mycelia, pseudomycelia, and blastophores. It is commonly part of the normal flora of the skin, mouth, intestinal tract, and vagina, but can cause a variety of infections, including CANDIDIASIS; ONYCHOMYCOSIS; vulvovaginal candidiasis (CANDIDIASIS, VULVOVAGINAL), and thrush (see CANDIDIASIS, ORAL). (From Dorland, 28th ed)
A unicellular budding fungus which is the principal pathogenic species causing CANDIDIASIS (moniliasis).
Infection with a fungus of the genus CANDIDA. It is usually a superficial infection of the moist areas of the body and is generally caused by CANDIDA ALBICANS. (Dorland, 27th ed)
The generic name for the group of aliphatic hydrocarbons Cn-H2n+2. They are denoted by the suffix -ane. (Grant & Hackh's Chemical Dictionary, 5th ed)
Substances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues.
The ability of fungi to resist or to become tolerant to chemotherapeutic agents, antifungal agents, or antibiotics. This resistance may be acquired through gene mutation.
The presence of fungi circulating in the blood. Opportunistic fungal sepsis is seen most often in immunosuppressed patients with severe neutropenia or in postoperative patients with intravenous catheters and usually follows prolonged antibiotic therapy.
Triazole antifungal agent that is used to treat oropharyngeal CANDIDIASIS and cryptococcal MENINGITIS in AIDS.
A species of MITOSPORIC FUNGI commonly found on the body surface. It causes opportunistic infections especially in immunocompromised patients.
An enzyme that catalyzes the formation of O-acetylcarnitine from acetyl-CoA plus carnitine. EC 2.3.1.7.
Electron-dense cytoplasmic particles bounded by a single membrane, such as PEROXISOMES; GLYOXYSOMES; and glycosomes.
A five-carbon sugar alcohol derived from XYLOSE by reduction of the carbonyl group. It is as sweet as sucrose and used as a noncariogenic sweetener.
Enzyme that catalyzes the final step of fatty acid oxidation in which ACETYL COA is released and the CoA ester of a fatty acid two carbons shorter is formed.
Procedures for identifying types and strains of fungi.
An enzyme that catalyzes the formation of acetoacetyl-CoA from two molecules of ACETYL COA. Some enzymes called thiolase or thiolase-I have referred to this activity or to the activity of ACETYL-COA C-ACYLTRANSFERASE.
Cyclic hexapeptides of proline-ornithine-threonine-proline-threonine-serine. The cyclization with a single non-peptide bond can lead them to be incorrectly called DEPSIPEPTIDES, but the echinocandins lack ester links. Antifungal activity is via inhibition of 1,3-beta-glucan synthase production of BETA-GLUCANS.
The study of the structure, growth, function, genetics, and reproduction of fungi, and MYCOSES.
Deoxyribonucleic acid that makes up the genetic material of fungi.
A form of invasive candidiasis where species of CANDIDA are present in the blood.
A fluorinated cytosine analog that is used as an antifungal agent.
Macrolide antifungal antibiotic produced by Streptomyces nodosus obtained from soil of the Orinoco river region of Venezuela.
Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses).
Five membered rings containing a NITROGEN atom.
A general term for single-celled rounded fungi that reproduce by budding. Brewers' and bakers' yeasts are SACCHAROMYCES CEREVISIAE; therapeutic dried yeast is YEAST, DRIED.
Compounds consisting of a short peptide chain conjugated with an acyl chain.
An appliance used as an artificial or prosthetic replacement for missing teeth and adjacent tissues. It does not include CROWNS; DENTAL ABUTMENTS; nor TOOTH, ARTIFICIAL.
Infection of the mucous membranes of the mouth by a fungus of the genus CANDIDA. (Dorland, 27th ed)
Colorless, endogenous or exogenous pigment precursors that may be transformed by biological mechanisms into colored compounds; used in biochemical assays and in diagnosis as indicators, especially in the form of enzyme substrates. Synonym: chromogens (not to be confused with pigment-synthesizing bacteria also called chromogens).
A kingdom of eukaryotic, heterotrophic organisms that live parasitically as saprobes, including MUSHROOMS; YEASTS; smuts, molds, etc. They reproduce either sexually or asexually, and have life cycles that range from simple to complex. Filamentous fungi, commonly known as molds, refer to those that grow as multicellular colonies.
The functional hereditary units of FUNGI.
Any liquid or solid preparation made specifically for the growth, storage, or transport of microorganisms or other types of cells. The variety of media that exist allow for the culturing of specific microorganisms and cell types, such as differential media, selective media, test media, and defined media. Solid media consist of liquid media that have been solidified with an agent such as AGAR or GELATIN.
Proteins found in any species of fungus.
An aquatic genus of the family, Pipidae, occurring in Africa and distinguished by having black horny claws on three inner hind toes.
The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.
A mitosporic fungal genus causing opportunistic infections, endocarditis, fungemia, a hypersensitivity pneumonitis (see TRICHOSPORONOSIS) and white PIEDRA.
Polysaccharides consisting of mannose units.
Substances of fungal origin that have antigenic activity.
An enzyme that catalyzes the first and rate-determining steps of peroxisomal beta-oxidation of fatty acids. It acts on COENZYME A derivatives of fatty acids with chain lengths from 8 to 18, using FLAVIN-ADENINE DINUCLEOTIDE as a cofactor.
An enzyme that catalyzes the oxidation of acyl-[acyl-carrier protein] to trans-2,3-dehydroacyl-[acyl-carrier protein] in the fatty acid biosynthesis pathway. It has a preference for acyl derivatives with carbon chain length from 4 to 16.
A key enzyme in the glyoxylate cycle. It catalyzes the conversion of isocitrate to succinate and glyoxylate. EC 4.1.3.1.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
A complex sulfated polymer of galactose units, extracted from Gelidium cartilagineum, Gracilaria confervoides, and related red algae. It is used as a gel in the preparation of solid culture media for microorganisms, as a bulk laxative, in making emulsions, and as a supporting medium for immunodiffusion and immunoelectrophoresis.
Techniques used in microbiology.
Neon. A noble gas with the atomic symbol Ne, atomic number 10, and atomic weight 20.18. It is found in the earth's crust and atmosphere as an inert, odorless gas and is used in vacuum tubes and incandescent lamps.
A mitosporic Tremellales fungal genus whose species usually have a capsule and do not form pseudomycellium. Teleomorphs include Filobasidiella and Fidobasidium.
Worthless, damaged, defective, superfluous or effluent material from industrial operations.
The oval-shaped oral cavity located at the apex of the digestive tract and consisting of two parts: the vestibule and the oral cavity proper.
Peptides whose amino and carboxy ends are linked together with a peptide bond forming a circular chain. Some of them are ANTI-INFECTIVE AGENTS. Some of them are biosynthesized non-ribosomally (PEPTIDE BIOSYNTHESIS, NON-RIBOSOMAL).
Anaerobic degradation of GLUCOSE or other organic nutrients to gain energy in the form of ATP. End products vary depending on organisms, substrates, and enzymatic pathways. Common fermentation products include ETHANOL and LACTIC ACID.
An enzyme that catalyzes reversibly the hydration of unsaturated fatty acyl-CoA to yield beta-hydroxyacyl-CoA. It plays a role in the oxidation of fatty acids and in mitochondrial fatty acid synthesis, has broad specificity, and is most active with crotonyl-CoA. EC 4.2.1.17.
A triazole antifungal agent that inhibits cytochrome P-450-dependent enzymes required for ERGOSTEROL synthesis.
A genus of mitosporic fungi containing about 100 species and eleven different teleomorphs in the family Trichocomaceae.
Technique that utilizes low-stringency polymerase chain reaction (PCR) amplification with single primers of arbitrary sequence to generate strain-specific arrays of anonymous DNA fragments. RAPD technique may be used to determine taxonomic identity, assess kinship relationships, analyze mixed genome samples, and create specific probes.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
Broad spectrum antifungal agent used for long periods at high doses, especially in immunosuppressed patients.
Enzymes that reversibly catalyze the oxidation of a 3-hydroxyacyl CoA to 3-ketoacyl CoA in the presence of NAD. They are key enzymes in the oxidation of fatty acids and in mitochondrial fatty acid synthesis.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
Enumeration by direct count of viable, isolated bacterial, archaeal, or fungal CELLS or SPORES capable of growth on solid CULTURE MEDIA. The method is used routinely by environmental microbiologists for quantifying organisms in AIR; FOOD; and WATER; by clinicians for measuring patients' microbial load; and in antimicrobial drug testing.
Immunoglobulins produced in a response to FUNGAL ANTIGENS.
Encrustations, formed from microbes (bacteria, algae, fungi, plankton, or protozoa) embedding in extracellular polymers, that adhere to surfaces such as teeth (DENTAL DEPOSITS); PROSTHESES AND IMPLANTS; and catheters. Biofilms are prevented from forming by treating surfaces with DENTIFRICES; DISINFECTANTS; ANTI-INFECTIVE AGENTS; and antifouling agents.
A species of the fungus CRYPTOCOCCUS. Its teleomorph is Filobasidiella neoformans.
Studies determining the effectiveness or value of processes, personnel, and equipment, or the material on conducting such studies. For drugs and devices, CLINICAL TRIALS AS TOPIC; DRUG EVALUATION; and DRUG EVALUATION, PRECLINICAL are available.
A pentose active in biological systems usually in its D-form.
The ability of microorganisms, especially bacteria, to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).
The major component of hemoglobin in the fetus. This HEMOGLOBIN has two alpha and two gamma polypeptide subunits in comparison to normal adult hemoglobin, which has two alpha and two beta polypeptide subunits. Fetal hemoglobin concentrations can be elevated (usually above 0.5%) in children and adults affected by LEUKEMIA and several types of ANEMIA.
A large, subclass of arachnids comprising the MITES and TICKS, including parasites of plants, animals, and humans, as well as several important disease vectors.
The alpha subunits of integrin heterodimers (INTEGRINS), which mediate ligand specificity. There are approximately 18 different alpha chains, exhibiting great sequence diversity; several chains are also spliced into alternative isoforms. They possess a long extracellular portion (1200 amino acids) containing a MIDAS (metal ion-dependent adhesion site) motif, and seven 60-amino acid tandem repeats, the last 4 of which form EF HAND MOTIFS. The intracellular portion is short with the exception of INTEGRIN ALPHA4.
A species of the genus SACCHAROMYCES, family Saccharomycetaceae, order Saccharomycetales, known as "baker's" or "brewer's" yeast. The dried form is used as a dietary supplement.

In vivo activity of micafungin in a persistently neutropenic murine model of disseminated infection caused by Candida tropicalis. (1/114)

Micafungin is a new echinocandin with broad-spectrum in vitro and in vivo antifungal activity against both Aspergillus and Candida species. We compared the activity of micafungin with that of amphotericin B and fluconazole in a persistently immunocompromised murine model of disseminated candidiasis against a strain of Candida tropicalis that was resistant to amphotericin B and fluconazole in vitro. Mice were rendered persistently neutropenic with multiple doses of cyclophosphamide and infected intravenously with C. tropicalis. Mice were treated with either intraperitoneal amphotericin B (0.5-5 mg/kg per dose), oral fluconazole (50 mg/kg twice a day), intravenous micafungin (1-10 mg/kg per dose) or solvent control for 7 days. Mice were killed at 11 days post-infection and kidneys, lungs, brain and liver removed for quantitative culture. Overall mortality in the model was low, with rates varying between 10% and 25% in treatment groups. Micafungin at doses between 2 and 10 mg/kg were the only regimes able to reduce cfu below the level of detection of tissues infected with C. tropicalis. Micafungin was well tolerated by the mice and was much more effective than amphotericin B or fluconazole against an amphotericin B- and fluconazole-resistant C. tropicalis.  (+info)

Candida tropicalis in a neonatal intensive care unit: epidemiologic and molecular analysis of an outbreak of infection with an uncommon neonatal pathogen. (2/114)

From June to July 1998, two episodes of Candida tropicalis fungemia occurred in the Aristotle University neonatal intensive care unit (ICU). To investigate this uncommon event, a prospective study of fungal colonization and infection was conducted. From December 1998 to December 1999, surveillance cultures of the oral cavities and perinea of the 593 of the 781 neonates admitted to the neonatal ICU who were expected to stay for >7 days were performed. Potential environmental reservoirs and possible risk factors for acquisition of C. tropicalis were searched for. Molecular epidemiologic studies by two methods of restriction fragment length polymorphism analysis and two methods of random amplified polymorphic DNA analysis were performed. Seventy-two neonates were colonized by yeasts (12.1%), of which 30 were colonized by Candida albicans, 17 were colonized by C. tropicalis, and 5 were colonized by Candida parapsilosis. From December 1998 to December 1999, 10 cases of fungemia occurred; 6 were due to C. parapsilosis, 2 were due to C. tropicalis, 1 was due to Candida glabrata, and 1 was due to Trichosporon asahii (12.8/1,000 admissions). Fungemia occurred more frequently in colonized than in noncolonized neonates (P < 0.0001). Genetic analysis of 11 colonization isolates and the two late blood isolates of C. tropicalis demonstrated two genotypes. One blood isolate and nine colonization isolates belonged to a single type. The fungemia/colonization ratio of C. parapsilosis (3/5) was greater than that of C. tropicalis (2/17, P = 0.05), other non-C. albicans Candida spp. (1/11, P = 0.02), or C. albicans (0/27, P = 0.05). Extensive environmental cultures revealed no common source of C. tropicalis or C. parapsilosis. There was neither prophylactic use of azoles nor other risk factors found for acquisition of C. tropicalis except for total parenteral nutrition. A substantial risk of colonization by non-C. albicans Candida spp. in the neonatal ICU may lead to a preponderance of C. tropicalis as a significant cause of neonatal fungemia.  (+info)

Up-regulation of the peroxisomal beta-oxidation system occurs in butyrate-grown Candida tropicalis following disruption of the gene encoding peroxisomal 3-ketoacyl-CoA thiolase. (3/114)

In the yeast Candida tropicalis, two thiolase isozymes, peroxisomal acetoacetyl-CoA thiolase and peroxisomal 3-ketoacyl-CoA thiolase, participate in the peroxisomal fatty acid beta-oxidation system. Their individual contributions have been demonstrated in cells grown on butyrate, with C. tropicalis able to grow in the absence of either one. In the present study, a lack of peroxisomal 3-ketoacyl-CoA thiolase protein resulted in increased expression (up-regulation) of acetoacetyl-CoA thiolase and other peroxisomal proteins, whereas a lack of peroxisomal acetoacetyl-CoA thiolase produced no corresponding effect. Overexpression of the acetoacetyl-CoA thiolase gene did not suppress the up-regulation or the growth retardation on butyrate in cells without peroxisomal 3-ketoacyl-CoA thiolase, even though large amounts of the overexpressed acetoacetyl-CoA thiolase were detected in most of the peroxisomes of butyrate-grown cells. These results provide important evidence of the greater contribution of 3-ketoacyl-CoA thiolase to the peroxisomal beta-oxidation system than acetoacetyl-CoA thiolase in C. tropicalis and a novel insight into the regulation of the peroxisomal beta-oxidation system.  (+info)

Preclinical assessment of the efficacy of mycograb, a human recombinant antibody against fungal HSP90. (4/114)

Mycograb (NeuTec Pharma plc) is a human genetically recombinant antibody against fungal heat shock protein 90 (HSP90). Antibody to HSP90 is closely associated with recovery in patients with invasive candidiasis who are receiving amphotericin B (AMB). Using in vitro assays developed for efficacy assessment of chemotherapeutic antifungal drugs, Mycograb showed activity against a wide range of yeast species (MICs against Candida albicans [fluconazole [FLC]-sensitive and FLC-resistant strains], Candida krusei, Candida tropicalis, Candida glabrata, and Candida parapsilosis, 128 to 256 microg/ml). Mycograb (4 or 8 microg/ml) showed synergy with AMB, the fractional inhibitory index being 0.09 to 0.31. Synergy was not evident with FLC, except for FLC-sensitive C. albicans. Murine kinetics showed that Mycograb at 2 mg/kg produced a maximum concentration of drug in serum of 4.7 microg/ml, a half-life at alpha phase of 3.75 min, a half-life at beta phase of 2.34 h, and an area under the concentration-time curve from 0 to t h of 155 microg. min/ml. Mycograb (2 mg/kg) alone produced significant improvement in murine candidiasis caused by each species: (i). a reduction (Scheffe's test, P < 0.05) in the mean organ colony count for the FLC-resistant strain of C. albicans (kidney, liver, and spleen), C. krusei (liver and spleen), C. glabrata (liver and spleen), C. tropicalis (kidney), and C. parapsilosis (kidney, liver, and spleen) and (ii). a statistically significant increase in the number of negative biopsy specimens (Fisher's exact test, P < 0.05) for C. glabrata (kidney), C. tropicalis (liver and spleen), and C. parapsilosis (liver). AMB (0.6 mg/kg) alone cleared the C. tropicalis infection but failed to clear infections caused by C. albicans, C. krusei, C. glabrata, or C. parapsilosis. Synergy with AMB, defined as an increase (Fisher's exact test, P < 0.05) in the number of negative biopsy specimens compared with those obtained using AMB alone, occurred with the FLC-resistant strain of C. albicans (kidney), C. krusei (spleen), C. glabrata (spleen), and C. parapsilosis (liver and spleen). Only by combining Mycograb with AMB was complete resolution of infection achieved for C. albicans, C. krusei, and C. glabrata.  (+info)

Candida tropicalis expresses two mitochondrial 2-enoyl thioester reductases that are able to form both homodimers and heterodimers. (5/114)

Here we report on the cloning of a Candida tropicalis gene, ETR2, that is closely related to ETR1. Both genes encode enzymatically active 2-enoyl thioester reductases involved in mitochondrial synthesis of fatty acids (fatty acid synthesis type II) and respiratory competence. The 5'- and 3'-flanking (coding) regions of ETR2 and ETR1 are about 90% (97%) identical, indicating that the genes have evolved via gene duplication. The gene products differ in three amino acid residues: Ile67 (Val), Ala92 (Thr), and Lys251 (Arg) in Etr2p (Etr1p). Quantitative PCR analysis and reverse transcriptase-PCR indicated that both genes were expressed about equally in fermenting and ETR1 predominantly respiring yeast cells. Like the situation with ETR1, expression of ETR2 in respiration-deficient Saccharomyces cerevisiae mutant cells devoid of Ybr026p/Etr1p was able to restore growth on glycerol. Triclosan that is used as an antibacterial agent against fatty acid synthesis type II 2-enoyl thioester reductases inhibited growth of FabI overexpressing mutant yeast cells but was not able to inhibit respiratory growth of the ETR2- or ETR1-complemented mutant yeast cells. Resolving of crystal structures obtained via Etr2p and Etr1p co-crystallization indicated that all possible dimer variants occur in the same asymmetric unit, suggesting that similar dimer formation also takes place in vivo.  (+info)

The European Confederation of Medical Mycology (ECMM) survey of candidaemia in Italy: antifungal susceptibility patterns of 261 non-albicans Candida isolates from blood. (6/114)

OBJECTIVES: To analyse the in vitro antifungal susceptibility of 261 non-albicans Candida bloodstream strains isolated during the European Confederation of Medical Mycology survey of candidaemia performed in Lombardia, Italy (September 1997-December 1999). METHODS: In vitro susceptibility to flucytosine, fluconazole, itraconazole, posaconazole and voriconazole was determined using the broth microdilution method described in the NCCLS M27-A guidelines. Etest strips were used to assess susceptibility to amphotericin B. In vitro findings were correlated with the patient's underlying condition and previous antifungal treatment. RESULTS: MICs (mg/L) at which 90% of the strains were inhibited were, respectively, 2 for flucytosine, 8 for fluconazole, 0.5 for itraconazole, 0.25 for voriconazole and 0.25 for posaconazole. Amphotericin B MIC endpoints were <0.50 mg/L in all the isolates tested. Flucytosine resistance was detected in 19 isolates (7%), mainly among Candida tropicalis strains (30%). Innate or secondary fluconazole resistance was detected in 13 strains (5%). Among the 13 patients with fluconazole-resistant Candida bloodstream infection, three were HIV positive, including one treated with fluconazole for oral candidosis; the four who were HIV negative had received the azole during the 2 weeks preceding the candidaemia. Cross-resistance among fluconazole and other azoles was a rare event. CONCLUSIONS: Resistance is still uncommon in non-albicans Candida species recovered from blood cultures. However, in fungaemias caused by C. tropicalis, Candida glabrata and Candida krusei, there is a high prevalence of resistance to fluconazole and flucytosine. Fluconazole resistance should be suspected in patients treated previously with azoles, mainly those with advanced HIV infection.  (+info)

Identification and characterization of the CYP52 family of Candida tropicalis ATCC 20336, important for the conversion of fatty acids and alkanes to alpha,omega-dicarboxylic acids. (7/114)

Candida tropicalis ATCC 20336 excretes alpha,omega-dicarboxylic acids as a by-product when cultured on n-alkanes or fatty acids as the carbon source. Previously, a beta-oxidation-blocked derivative of ATCC 20336 was constructed which showed a dramatic increase in the production of dicarboxylic acids. This paper describes the next steps in strain improvement, which were directed toward the isolation and characterization of genes encoding the omega-hydroxylase enzymes catalyzing the first step in the omega-oxidation pathway. Cytochrome P450 monooxygenase (CYP) and the accompanying NADPH cytochrome P450 reductase (NCP) constitute the hydroxylase complex responsible for the first and rate-limiting step of omega-oxidation of n-alkanes and fatty acids. 10 members of the alkane-inducible P450 gene family (CYP52) of C. tropicalis ATCC20336 as well as the accompanying NCP were cloned and sequenced. The 10 CYP genes represent four unique genes with their putative alleles and two unique genes for which no allelic variant was identified. Of the 10 genes, CYP52A13 and CYP52A14 showed the highest levels of mRNA induction, as determined by quantitative competitive reverse transcription-PCR during fermentation with pure oleic fatty acid (27-fold increase), pure octadecane (32-fold increase), and a mixed fatty acid feed, Emersol 267 (54-fold increase). The allelic pair CYP52A17 and CYP52A18 was also induced under all three conditions but to a lesser extent. Moderate induction of CYP52A12 was observed. These results identify the CYP52 and NCP genes as being involved in alpha,omega-dicarboxylic acid production by C. tropicalis and provide the foundation for biocatalyst improvement.  (+info)

Transformation of fatty acids catalyzed by cytochrome P450 monooxygenase enzymes of Candida tropicalis. (8/114)

Candida tropicalis ATCC 20336 can grow on fatty acids or alkanes as its sole source of carbon and energy, but strains blocked in beta-oxidation convert these substrates to long-chain alpha,omega-dicarboxylic acids (diacids), compounds of potential commercial value (Picataggio et al., Biotechnology 10:894-898, 1992). The initial step in the formation of these diacids, which is thought to be rate limiting, is omega-hydroxylation by a cytochrome P450 (CYP) monooxygenase. C. tropicalis ATCC 20336 contains a family of CYP genes, and when ATCC 20336 or its derivatives are exposed to oleic acid (C(18:1)), two cytochrome P450s, CYP52A13 and CYP52A17, are consistently strongly induced (Craft et al., this issue). To determine the relative activity of each of these enzymes and their contribution to diacid formation, both cytochrome P450s were expressed separately in insect cells in conjunction with the C. tropicalis cytochrome P450 reductase (NCP). Microsomes prepared from these cells were analyzed for their ability to oxidize fatty acids. CYP52A13 preferentially oxidized oleic acid and other unsaturated acids to omega-hydroxy acids. CYP52A17 also oxidized oleic acid efficiently but converted shorter, saturated fatty acids such as myristic acid (C(14:0)) much more effectively. Both enzymes, in particular CYP52A17, also oxidized omega-hydroxy fatty acids, ultimately generating the alpha,omega-diacid. Consideration of these different specificities and selectivities will help determine which enzymes to amplify in strains blocked for beta-oxidation to enhance the production of dicarboxylic acids. The activity spectrum also identified other potential oxidation targets for commercial development.  (+info)

Asian Pacific Journal of Tropical Biomedicine Available online 5 October 2017 In Press, Accepted Manuscript Author links open overlay panelMaria A.Freitas1Antonia T.L.Santos1Antonio J.T.Machado1Ana Raquel P.Silva1Fábia F.Campina1Maria S.Costa1Gioconda M.A.B.Martins1Maria Flaviana B.Morais-Braga1Saulo R.Tintino1Irwin R.A.Menezes1JaimeRibeiro-Filho1Altevir P.Medeiros2Adeliana S.Oliveira3Patrício B.Maracajá4Henrique D.M.Coutinho1 Show more https://doi.org/10.1016/j.apjtb.2017.09.018Get rights and content Open Access funded by Hainan Medical University Under a Creative Commons licenseopen access Abstract Objective To investigate the antifungal activity of the fern species Lygodium venustum and Pityrogramma calomelanos (P. calomelanos) against Candida albicans and Candida tropicalis strains. Methods The microdilution method was used to evaluate the antifungal activity, as well as the modulating effects of ethanolic extracts of these plants in combination with fluconazole. The minimum inhibitory ...
An 18-month epidemiologic investigation of Candida bloodstream infections in a Singapore hospital identified 52 candidemic patients: 36% of whose infections were caused by C. tropicalis, 29% were due to C. albicans, 10% with C. parapsilosis and 21% involved C. glabrata. A predominant clonal C. tropicalis strain was demonstrated. No association with ICU stay, prior exposure to fluconazole/broad-spectrum antibiotics or increased mortality was found in this apparent shift towards non-C. albicans Candida species as the primary agents of candidemia ...
The echinocandin MK-0991, formerly L-743,872, is a water-soluble lipopeptide that has been demonstrated in preclinical studies to have potent activity against Candida spp., Aspergillus fumigatus, and Pneumocystis carinii. An extensive in vitro biological evaluation of MK-0991 was performed to better define the potential activities of this novel compound. Susceptibility testing with MK-0991 against approximately 200 clinical isolates of Candida, Cryptococcus neoformans, and Aspergillus isolates was conducted to determine MICs and minimum fungicidal concentrations MF(s). The MFC at which 90% of isolates are inhibited for 40 C. albicans clinical isolates was 0.5 microg/ml. Susceptibility testing with panels of antifungal agent-resistant species of Candida and C. neoformans isolates indicated that the MK-0991 MFCs for these isolates are comparable to those obtained for susceptible isolates. Growth kinetic studies of MK-0991 against Candida albicans and Candida tropicalis isolates showed that the ...
Candida tropicalis ATCC ® 750D-5™ Designation: Genomic DNA from Candida tropicalis CBS 94 (ATCC ® 750™) Application:
Candida tropicalis ATCC ® 750D-5™ Designation: Genomic DNA from Candida tropicalis CBS 94 (ATCC ® 750™) Application:
Candida tropicalis SIS2 protein: regulates expression of sodium-extrusion ATPase encoded by ENA1; isolated from Candida tropicalis; amino acid sequence in first source; GenBank X88900
Studies have shown that radiation from radiotherapy increases the yeast colonization of patients. However it is not clear, if such radiation alters the yeast itself. The aim of the present study was therefore to report the direct impact of gamma radiation on Candida tropicalis. C. tropicalis was obtained from a patient with a carcinoma, a suspension of this yeast containing 2.0 × 103 colony forming units per milliliter was prepared. It was submitted to gamma radiation dosage similar to that used in the treatment of head and neck cancer. After a cumulative dose of 7200 cGy some virulence attributes of C. tropicalis, including macro and micromorphological characteristics, adhesion and biofilm abilities, murine experimental infection and phagocytosis resistance were evaluated on irradiated and non-irradiated yeasts. After irradiation the colony morphology of the yeast was altered from a ring format to a smooth appearance in most colonies. Scanning
We report a methodology for the isolation of peroxisome membranes from the yeast Candida tropicalis pK233 grown on oleic acid, and the characterization of the polypeptide and lipid compositions of these membranes. Peroxisomes purified in either sucrose or Nycodenz gradients are treated with Tris-HCl (pH 8.5) and then with sodium carbonate (pH 11.5) to yield a final peroxisome membrane preparation (hereafter called peroxisome membranes). Electron microscopy revealed peroxisome membranes that are approximately 8.1 nm thick, have a typical trilaminar appearance, and form either flattened sheets or whorled structures. Peroxisome membranes contain 3.1% and 2.2% of the total protein of sucrose- and Nycodenz-gradient-purified peroxisomes, respectively. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis analysis showed three predominant polypeptide bands of 34 (PMP 34), 29 (PMP 29), and 24 (PMP 24) × 10(3) Mr in peroxisome membranes. Immunoblotting with an antiserum to PMP 24 showed that PMP ...
Article Biological decolorization of industrial dyes by |italic|Candida tropicalis|/italic| and |italic|Bacillus firmus|/italic|. Disperse dyes are chiefly used by textile industries for the coloration of polyester and cellulose triacetate and their ...
This work aims to utilize fly ash from a thermal power station for melanoidin reduction from distillery effluent by adsorption. To accomplish this, coal fl
What is Candida tropicalis? Candida tropicalis is a yeast form of fungi known to be pathogenic in neutropenic hosts and disseminating through the bloodstream to peripheral organs. It is closely related to Candida albicans in pathogenicity and clinical features. It is a common systemic fungus, affecting persons with immune-compromised and immune-suppressed systems. The common treatment therapies for invasive infection of …. Read moreCandida tropicalis- An Overview ...
ID C5MBN0_CANTT Unreviewed; 570 AA. AC C5MBN0; DT 28-JUL-2009, integrated into UniProtKB/TrEMBL. DT 28-JUL-2009, sequence version 1. DT 07-JUN-2017, entry version 36. DE SubName: Full=Uncharacterized protein {ECO:0000313,EMBL:EER33047.1}; GN ORFNames=CTRG_03472 {ECO:0000313,EMBL:EER33047.1}; OS Candida tropicalis (strain ATCC MYA-3404 / T1) (Yeast). OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; OC Saccharomycetes; Saccharomycetales; Debaryomycetaceae; OC Candida/Lodderomyces clade; Candida. OX NCBI_TaxID=294747 {ECO:0000313,EMBL:EER33047.1, ECO:0000313,Proteomes:UP000002037}; RN [1] {ECO:0000313,EMBL:EER33047.1, ECO:0000313,Proteomes:UP000002037} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC MYA-3404 / T1 {ECO:0000313,Proteomes:UP000002037}; RX PubMed=19465905; DOI=10.1038/nature08064; RA Butler G., Rasmussen M.D., Lin M.F., Santos M.A., Sakthikumar S., RA Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., RA Agrafioti I., Arnaud M.B., Bates S., Brown ...
Kor lovce jsou jedl houby, kter se dlouhodob vyu vaj v lidov medic n v chodn ch zem . Jedn m z nejd le vyu van ch kor lovc je kor lovec je at zvan yamabushitake nebo tak houtou , kter m sv pevn m sto v tradi n nsk medic n v terapii nemoc tr vic ho syst mu. Z padn medic na, kter je k vychvalovan m z zra n m houb m zna n skeptick , dlouhojejich l ebn efekt p ehl ela. Farmaceutick a farmakologick v zkum kor lovc v nich v ak odhalil adu biologicky inn ch l tek, kter mo n jednou najdou uplatn n i v modern medic n . V tomto sm ru jsou zaj mav zejm na polysacharidy s protin dorov m a antimutagenn m inkem. P sob tak jako l tky, kter zvy uj odolnost organismu aktivac imunitn ho syst mu. Aktivuj toti fagocyt rn funkce makrof g , bun k imunitn soustavy, kter se spolu s cytokiny pod lej na nespecifick imunit organismu. Fagocyt rn funkce makrof g m v znam zejm na p i zne kod ov n cizorod ch l tek v organismu, jak mi jsou viry, bakterie nebo pl sn . Makrof gy tak sni uj hladiny p ebyte n ch l tek poch zej c ...
The article gives the use of rye stillage by during cultivation process of fodder yeast Candida utilis and Candida tropicalis. Experiments concerned the impact of fodder yeast culture on the amount of protein formed in during cultivation process on stillage. In this studies were also conducted research with an additional carbon source to increase the yield of protein by yeast. On the basis of the results obtained it was found the highest increase of yeast biomass in the case of the application of two strains of yeast: Candida utilis and Candida tropicalis by cultivation process on rye stillage. The use of nitrogen and phosphorus in the form of mineral compounds in cultivation process resulted in an increase the amount of biomass of yeast in the stillage ...
Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Técnicas In Vitro / Parede Celular / Anacardiaceae / Candida tropicalis / Infecção Focal Dentária / Micoses País/Região como assunto: América do Sul / Brasil Idioma: Inglês Revista: Acta odontol. latinoam Assunto da revista: Odontologia Ano de publicação: 2012 Tipo de documento: Artigo País de afiliação: Brasil Instituição/País de afiliação: Federal University of Paraíba/BR / Federal University of Pernambuco/BR / State University of Campinas/BR ...
Ethanol has been reported to cause mycelial growth in Candida tropicalis Pk233, and mycelial growth has also been shown to be abolished by concomitant addition of myo-inositol. In this study, the process of ethanol-induced mycelial growth in this organism was examined in combination with cytological characterization of actin localization. Cultivation with ethanol gave biphasic growth curves. During the first growth phase (doubling time 2.4 h), there was an accumulation of swollen spherical yeast cells, instead of the oblong ones observed in the control culture, followed by the appearance of spherical daughter cells in chains. Randomly distributed actin patches were observed on these swollen yeast cells and the bud initiation sites of these cells appeared random. These observations suggested that ethanol caused depolarization of cell growth during the first phase. During the second growth phase (doubling time 7.4 h), pseudohyphal cells appeared, projecting from the swollen yeast cells. Activity of
(PhysOrg.com) -- With the goal to reduce our dependence on fossil fuels, scientists are looking for alternative methods to produce plastics that are based on renewable oils. In a new study, scientists have developed a method to produce a bioplastic by engineering a strain of the Candida tropicalis yeast. Their results demonstrate the possibility of producing low-cost, commercially viable yields of omega-hydroxyfatty acids, a new family of monomers that can be converted to bioplastics which could eventually be used for a variety of applications.
XILITOL MENGGUNAKAN KHAMIR CANDIDA TROPICALIS Bidang Kegiatan : PKM Gagasan Tertulis Diusulkan Oleh : Ketua Kelompok : Affan Iqbal 1. Taufik Rais ( G84080022/2010) ( F24080055/2010) Anggota kelompok : 2. Ayu Fitriana ( H44080050/2010) INSTITUT PERTANIAN BOGOR BOGOR 2010 i . Ringkasan Limbah tandan kosong kelapa sawit (TKKS) di Indonesia yang jumlahnya sangat banyak, menyimpan potensi untuk dimanfaatkan menjadi produk gula yang bernilai tinggi yaitu xilitol. Kandungan hemiselulosa pada limbah ini mencapai 28% berat kering. Hemiselulosa tersebut menghasilkan (±) 33% xilosa sehingga sangat potensial jika diproses menjadi gula xilitol. Proses produksi xilitol pada awalnya menggunakan teknik hidrogenasi xilosa murni yang mahal dan sulit. Tapi dengan ditemukannya proses bioteknologi fermentasi yang memanfaatkan metabolisme khamir. Proses konversi menjadi lebih murah dan efesien. Abstract Waste of Oil palm empty-fruit-bunch (TKKS) in Indonesia is in great number, it has potential to be used to ...
GenEZ™ ORF cDNA clones makes it easy to order customized expression-ready ORF clones from the worlds largest commercial ORF clone database. You can Browse ORF cDNA clones by species Xenopus tropicalis, page 196
GenEZ™ ORF cDNA clones makes it easy to order customized expression-ready ORF clones from the worlds largest commercial ORF clone database. You can Browse ORF cDNA clones by species Xenopus tropicalis, page 1
Domain architectures containing both Cysteine-rich domain and PH domain-like in Xenopus tropicalis 76_4.2. Links to architectures containing these domain pairs in other groups of genomes are provided. Domain pairs which are not adjacent can be added/removed.
Resumption of meiosis in oocytes of Xenopus tropicalis required translation but not transcription, and was marked by the appearance of a white spot and a dark ring, coincident with entry into metaphase I and the onset of anaphase I, respectively. Cyclin B(2)/p34(cdc2) activity increased prior to the …
Opens the Highlight Feature Bar and highlights feature annotations from the FEATURES table of the record. The Highlight Feature Bar can be used to navigate to and highlight other features and provides links to display the highlighted region separately. Links in the FEATURES table will also highlight the corresponding region of the sequence. More... ...
p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.,/p> ,p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.,/p> ,p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).,/p> ,p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x,sup>64,/sup> + x,sup>4,/sup> + x,sup>3,/sup> + x + 1. The algorithm is described in the ISO 3309 standard. ,/p> ,p class=publication>Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.,br /> ,strong>Cyclic redundancy and other checksums,/strong>,br /> ,a href=http://www.nrbook.com/b/bookcpdf.php>Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993),/a>),/p> Checksum:i ...
p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.,/p> ,p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.,/p> ,p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).,/p> ,p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x,sup>64,/sup> + x,sup>4,/sup> + x,sup>3,/sup> + x + 1. The algorithm is described in the ISO 3309 standard. ,/p> ,p class=publication>Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.,br /> ,strong>Cyclic redundancy and other checksums,/strong>,br /> ,a href=http://www.nrbook.com/b/bookcpdf.php>Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993),/a>),/p> Checksum:i ...
Candida tropicalis is a diploid ascomycetes yeast responsible for 4%-24% of candidemia. Resistance to flucytosine is rarely described for this species but was observed for 45 (35%) of 130 C. tropicalis isolates recovered from blood cultures in the Paris area in a 4-year survey. The aims of this study were to test the hypothesis that the flucytosine-resistant isolates could represent a subgroup and to determine the relationship between epidemiologic and genomic data. Epidemiologic data and gene sequences were analyzed, and molecular typing was performed. Our results suggest that a clone of flucytosine-resistant isolates, associated with malignancies and a lower mortality than that for other C. tropicalis isolates, is widespread in the Paris area. We propose the analysis of 2 polymorphic microsatellite markers coupled with URA3 sequencing to track the clone.
Proven microbial species in burn wounds: Initially Escherichia coli, Pseudomonas putida, Enteroccus faecalis, MSSA, Enterobacter cloacae and Candida tropicalis. Later on positive cultures with Serratia marcescens and Citrobacter freundii (tracheal secretion MSSA and Serratia liquefaciens). Late positive cultures with Trichosporon mucoides or mucormycosis (sensitive to voriconazole and amphotericine B). Proven sepsis with positive blood cultures (MSSA, Candida tropicalis ...
TY - JOUR. T1 - Candida tropicalis Etr1p and Saccharomyces cerevisiae Ybr026p (Mrf1p), 2-enoyl thioester reductases essential for mitochondrial respiratory competence. AU - Torkko, Juha. AU - Koivuranta, Kari. AU - Miinalainen, Ilkka. AU - Yagi, Ahmed. AU - Schmitz, Werner. AU - Kastaniotis, Alexander. AU - Airenne, Tomi. AU - Gurvitz, Aner. AU - Hiltunen, Kalervo. PY - 2001. Y1 - 2001. N2 - We report here on the identification and characterization of novel 2-enoyl thioester reductases of fatty acid metabolism, Etr1p from Candida tropicalis and its homolog Ybr026p (Mrf1′p) from Saccharomyces cerevisiae. Overexpression of these proteins in S. cerevisiae led to the development of significantly enlarged mitochondria, whereas deletion of the S. cerevisiae YBR026c gene resulted in rudimentary mitochondria with decreased contents of cytochromes and a respiration-deficient phenotype. Immunolocalization and in vivo targeting experiments showed these proteins to be predominantly mitochondrial. ...
Phenols and its derivatives are environmental pollutant commonly found in many industrial effluents. It is toxic in nature and causes various health hazards. However, they are poorly removed in conventional biological processes due to their toxicity. Immobilization of microbial cells has received increasing interest in the field of waste treatment and creates opportunities in a wide range of sectors including environmental pollution control. Live cells of phenol-degrading yeast, Candida tropicalis RETL-Cr1, were immobilized on coconut husk and loofah by adsorption. The immobolized particle was packed into biofilter column which used for continuous treatment of a phenol with initial phenol concentration of 3mM. Both loofah and coconut husk have similar phenol biodegradation rate of 0.0188 gL-1h -1 within 15 hours to achieve a phenol removal efficiency of 100 %. However loofah have lower biomass concentration of 4.22 gL-1 compared to biomass concentration on coconut husk, 4.39 gL-1 . Coconut husk ...
Nosocomial Candida albicans infections are a significant problem in neonatal intensive care units (NICUs). We investigated the clonality of C. albicans isolates recovered over an 8-year period from neonates at a NICU. We also validated multilocus sequence typing (MLST) compared with pulsed-field gel electrophoresis (PFGE) for the genotyping of C. albicans strains from the same NICU. A total of 43 clinical isolates (10 blood, 19 urine, and 14 other) were obtained from 43 neonates between 2005 and 2012. Clonal strains were defined as the isolation of two or more strains with identical or similar genotypes as determined with both MLST and PFGE. Using MLST, the 43 isolates yielded 25 diploid sequence types (DSTs) and 10 DSTs were shared by 28 isolates (65.1%). Among the 28 isolates sharing 10 DSTs, isolates from each of seven DSTs had the same or similar PFGE pattern. In addition, two sets of isolates that differed by MLST at only one locus had the same or similar PFGE pattern. Overall, when the MLST and
This study aimed at investigating the genetic diversity of a panel of Candida africana strains recovered from vaginal samples in different countries. All fungal strains were heterozygous at the mating type-like locus and belonged to the genotype A of Candida albicans. Moreover, all examined C. africana strains lack N-acetylglucosamine assimilation and sequence analysis of the HXK1 gene showed a distinctive polymorphism that impair the utilization of this aminosugar in this yeast.Multilocus sequencing of seven housekeeping genes revealed a substantial genetic homogeneity among the strains, except for the CaMPIb and VPS13 loci which contributed significantly to the classification of our set of C. africana strains into 6 existing diploid sequence types. Amplified fragment length polymorphism (AFLP) fingerprint analysis yielded greater genotypic heterogeneity among the C. africana strains. Overall the data reported here show that in C. africana genetic diversity occurs and the existence of this intriguing
TY - GEN. T1 - Enhanced xylitol production through simultaneous co-consumption of cellobiose and xylose by an engineereed saccharomyces cerevisiae strain. AU - Oh, Eun Joong. AU - Ha, Suk Jin. AU - Kim, Soo Rin. AU - Galazka, Jonathan M.. AU - Cate, Jamie H.D.. AU - Su Jin, Yong. PY - 2011/1/1. Y1 - 2011/1/1. UR - http://www.scopus.com/inward/record.url?scp=85054765849&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=85054765849&partnerID=8YFLogxK. M3 - Conference contribution. AN - SCOPUS:85054765849. SN - 9781618397362. T3 - Fuels and Petrochemicals Division - Core Programming Topic at the 2011 AIChE Annual Meeting. BT - Fuels and Petrochemicals Division - Core Programming Topic at the 2011 AIChE Annual Meeting. PB - AIChE. ER - ...
Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Apr 1;65(Pt 4):419-21. doi: 10.1107/S1744309109008719. Epub 2009 Mar 26. Research Support, Non-U.S. Govt
Two phrap contigs that appear to conflict with available physical mapping data are retained in the diploid sequence (Table 1). These known discrepancies between the final diploid assembly and the physical map involve ,1% of the genome. In some cases, phrap contigs span the major repeat sequence (MRS) of C. albicans. Assemblies across large repeats such as the MRS are probably not reliable.. Our assembled rDNA sequence (see additional data at http://genome-www.stanford.edu/candida-pnas2004-supplement) gives a repeating unit of 12,756 base pairs and indicates that the haploid genome encodes ≈55 copies of the shorter, intronless class of rDNA (see Table 1). The arrangement of the rRNA genes in strain SC5314 is similar to that in Saccharomyces cerevisiae with the addition of a low-complexity region of ≈2 kb. This region varies among strains and is used in various DNA typing schemes. Analysis of traces that contain partial rDNA sequences suggest that the repeat is located between supercontigs ...
Candida albicans gram poor iyeastcure. Candida albicans gram terrible can girl bladder contamination purpose itching with frame ecology candida and yeast make high-quality you exercise proper hygiene. Is candida albicans gram nice or bad? How can this. Is candida albicans gram fine or poor? Whats the distinction among gram fine and gram poor micro organism? Are they the same as a plague? Candida albicans masquerading as gramnegative. Tion of candida albicans as gramnegative bacilli (gnb) when inoculated into vitek automatic identity systems and can involve grampositive, gramnegative or yeast. Candida albicans parasitic yeast infestation. Candida albicans is a yeast infestation, from a parasite that thrives in warmblooded animals. In the allopathic international of medication its miles referred as a fungus. Candida species superb candida albicans gram superb. Candida species superb candida albicans gram fine or terrible candida species nice candida tropicalis homeopathic. Candida albicans gram ...
Fingerprint Dive into the research topics of Quantification of thigmotropism (contact sensing) of Candida albicans and Candida tropicalis. Together they form a unique fingerprint. ...
Frequencies of sensitisation to Blo t 5 in Taiwanese and Malaysian patients sera were shown to be 91.8% and 73.5%, respectively (24). Other studies have reported Blo t 5 to be a major allergen, with sensitisation rates of up to 70% in populations prone to B. tropicalis allergy (22). Most patients appear to be concurrently sensitised to D. pteronyssinus, and around 18% of patients may be found to be sensitised to B. tropicalis as a result of cross-reactivity of D. pteronyssinus (12). In a Colombian study, 24% of mite-allergic patients were shown to have IgE binding to B. tropicalis extract (20). A study compared the importance of 2 types of sensitisation: to B. tropicalis and D. pteronyssinus among asthma patients from Florida, Puerto Rico, and Brazil; and to D. pteronyssinus among patients from the United States and the United Kingdom. IgE antibodies to recombinant Blo t 5 were found in 45% of sera from B. tropicalis-allergic asthmatics in the group from Florida, Puerto Rico, and Brazil, ...
The caudal-related (Cdx) homeodomain transcription factors have a conserved role in the development of posterior structures in both vertebrates and invertebrates. A particularly interesting finding is that Cdx proteins have an important function in the regulation of expression from a subset of Hox genes. In this study, we report the cloning of cDNAs from the Cdx genes of the amphibian Xenopus tropicalis. Xenopus tropicalis is a diploid species, related to the commonly used laboratory animal Xenopus laevis, and has attracted attention recently as a potential genetic model for animal development. The Xenopus tropicalis cDNAs, Xtcad1, Xtcad2, and Xtcad3, show between 88 and 94% sequence identity with their Xenopus laevis orthologues. This finding corresponds to between 90 and 95% identity at the level of derived amino acid sequence. We also present a detailed description of Xtcad1, Xtcad2, and Xtcad3 expression during normal development. In common with the Cdx genes of other vertebrates, the ...
Candida albicans is part of the human microflora. Excessive and unimpeded growth is generated by a disruption of the sensitive balance and manifests itself in form of oral and/or vaginal soor. Spread of Candida in body tissues causes a systemic candidiasis. Even though there are more than 100 species of Candida, only 7 have been isolated with greater frequency from medical samples. In over 80% of the fungus isolates, Candida albicans and Candida tropicalis are found. Due to colonization of mucous membranes with Candida albicans and its passage into the hosts blood stream, the humoral immune system is stimulated, which results in the production of antibodies against Candida albicans. Generally, shortly after the antigen infringement, Candida albicans-specific IgM-antibodies are produced which are followed by an increase in specific IgG antibodies. Excessive infection of mucous membranes can lead to a high titer of Candida albicans-specific IgA-antibodies.. Test principle: ...
In the present study, we have prepared chitosan-carbon nanotube (Chitosan-CNT) hydrogels by the freeze-lyophilization method and examined their antimicrobial activity. Different concentrations of CNT were used in the preparation of Chitosan-CNT hydrogels. These differently concentrated CNT hydrogels were chemically characterized using Fourier Transform-Infrared Spectroscopy, Scanning Electron Microscopy and Optical microscopy. The porosity of the hydrogels were found to be >94%. Dispersion of chitosan was observed in the CNT matrix by normal photography and optical microscopy. The addition of CNT in the composite scaffold significantly reduced the water uptake ability. In order to evaluate antimicrobial activity, the serial dilution method was used towards Staphylococcus aureus, Escherichia coli and Candida tropicalis. The composite Chitosan-CNT hydrogel showed greater antimicrobial activity with increasing CNT concentration, suggesting that Chitosan-CNT hydrogel scaffold will be a promising
Severe infections caused by non-albicans Candida species are being increasingly reported among infants in neonatal intensive care units. To assess relative severity, mortality rates for C. albicans (CA) and C. parapsilosis (CP) infections in one neonatal intensive care unit from 1980 to 1990 were co …
|p| Infections caused by non-albicans Candida spp. are an important medical problem in people from risk groups, e.g. hematooncological patients. The aim of this paper was to analyse the in vitro activity of micafungin against 30 clinical isolates of non-albicans Candida spp. (C. glabrata, C. famata, C. tropicalis, C. inconspicua, C. lusitaniae, C. parapsilosis, C. krusei) by way of the E-test procedure, allowing determination of minimal inhibitory concentration (MIC). Data presented in this paper indicate that most of the studied clinical isolates - 27 (90%) showed sensitivity to micafungin, with MIC values ranging from 0.004 to 2 mg/l, while 3 (10%) isolates, including 2 isolates of C. tropicalis and 1 isolate of C. famata, were resistant to micafungin, with MIC values > 32 mg/l. The MIC|sub|50|/sub| and MIC|sub|90|/sub| values of micafungin, defined as MIC inhibited growth of 50% or 90% of the isolates studied, were 0.008 mg/l or 2 mg/l, respectively. In the case of C. glabrata isolates, MICs
Despite being associated with a high mortality and economic burden, data regarding candidemia are scant in Algeria. The aim of this study was to unveil the epidemiology of candidemia in Algeria, evaluate the antifungal susceptibility pattern of causative agents and understand the molecular mechanisms of antifungal resistance where applicable. Furthermore, by performing environmental screening and microsatellite typing we sought to identify the source of infection. We performed a retrospective epidemiological-based surveillance study and collected available blood yeast isolates recovered from the seven hospitals in Algiers. To identify the source of infection, we performed environmental screening from the hands of healthcare workers (HCWs) and high touch areas. Species identification was performed by API Auxa-Color and MALDI-TOF MS and ITS sequencing was performed for species not reliably identified by MALDI-TOF MS. Antifungal susceptibility testing followed CLSI M27-A3/S4 and included all blood and
TY - JOUR. T1 - Genetic Evaluation of Peroxisomal and Cytosolic Acetoacetyl-CoA Thiolase Isozymes in n-Alkane-Assimilating Diploid Yeast, Candida tropicalis. AU - Ueda, Mitsuyoshi. AU - Kanayama, Naoki. AU - Tanaka, Atsuo. PY - 2000. Y1 - 2000. N2 - The n-alkane-assimilating diploid yeast, Candida tropicalis, possesses two acetoacetyl-CoA thiolase (Thiolase I) isozymes encoded by one allele: peroxisomal and cytosolic Thiolase Is encoded by both CT-T1A and CT-T1B. To clarify the function of peroxisomal and cytosolic Thiolase Is, the site-directed mutation leading Thiolase I ΔC6 without a putative C-terminal peroxisomal targeting signal was introduced on CT-T1A locus in the ct-t1bΔ-null mutant. The C-terminus-truncated Thiolase I was active and solely present in the cytosol. Although the ct-t1aΔ/t1bΔ-null mutants showed mevalonate auxotrophy, the mutants having the C-terminus-truncated Thiolase I did not require mevalonate for growth, as did the strains having cytosolic Thiolase I. These ...
Among the members of the genusCandida, Candida albicans, Candida tropicalis, Candida glabrata, and Candida parapsilosis formerly represented more than 80% of the usual clinical Candida isolates, while Candida kruseiwas only sporadically isolated (11) and was regarded as a commensal organism (13, 24). During the past decade,C. krusei has been recognized as a true pathogen, particularly in immunocompromised patients. The resistance of this organism to fluconazole and the systematic use of this drug may explain the significant increase in the numbers of C. kruseiinfections, (9, 20, 31). In contrast to C. albicans, only a few articles concerning the potential virulence of C. krusei have been published (10, 12, 14, 15, 21,22, 25, 26). Likewise, relatively few studies have been conducted to characterize antigens of C. krusei, and no monoclonal antibody (MAb) specific to this yeast has yet been developed. The present study concerns the description of a MAb (MAb 6B3) specific for the species C. krusei. ...
VILLALBA CADAVID, Marcela; VELEZ URIBE, Tatiana; ARIAS ZABALA, Mario and ARRAZOLA PATERNINA, Guillermo. XYLITOL PRODUCTION FROM RICE HUSK USING Candida guilliermondii. Rev. Fac. Nac. Agron. Medellín [online]. 2009, vol.62, n.1, pp.4897-4905. ISSN 0304-2847.. In this study was used rice husk, previosly hydrolyzed with diluted sulfuric acid at 121 ºC and 15 psig, with a residence time 60 min. The initial concentration of substrate, inoculum, and relationship between media volume/flask volume and their combined effects were studied on the production of xylitol. The initial concentrations of 80 g/l xylose and 5 g/l inoculums led the best xylitol production (45.2 g/l), productivity (0.23 g/l•h) and yield (0.57 g/g).. Keywords : Husk rice; acid hydrolysis; xylose; xylitol; Candida guilliermondii. ...
Candidal infections are extremely common (see the images below).{file44305}{file44306}Candida albicans is the most common cause of human candidal infections, but other pathogenic species include Candida glabrata, Candida parapsilosis, Candida tropicalis, Candida krusei, Candida lusitaniae, and Candida stellatoidea.
Balanitis - an easy to understand guide covering causes, diagnosis, symptoms, treatment and prevention plus additional in depth medical information.No it can not. Log In Sign Up. entertainment tech lifestyle food health politics money sports All Sections.Can valtrex cause yeast infection View pyoderma, emergency care and treatment Sections 1-16.Family physicians also must remember that vaginal yeast infections may be caused by species other than C. albicans, such as Candida glabrata and Candida tropicalis.. ...
Antifungal Activity of Oleoresin and Fractions of Pinus elliottii Engelm and Pinus tropicalis against Phytopathogens. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
Loke, John Bernard; Alvarez, Elizabeth; Corredor, J.A.; Folgueras Montiel, Maryluz; Jaramillo, Gustavo; Ceballos, Hernán. 2004. Preliminay evidence of correlation between foliar and root resistance to root rot caused by Phytophthora tropicalis in cassava [poster]. Centro Internacional de Agricultura Tropical (CIAT), Cali, CO. 1 poster ...
We present a genetic map for Xenopus tropicalis, consisting of 2886 Simple Sequence Length Polymorphism (SSLP) markers. Using a bioinformatics-based strategy, we identified unique SSLPs within the X. tropicalis genome. Scaffolds from X. tropicalis genome assembly 2.0 (JGI) were scanned for Simple Sequence Repeats (SSRs); unique SSRs were then tested for amplification and polymorphisms using DNA from inbred Nigerian and Ivory Coast individuals. Thus identified, the SSLPs were genotyped against a mapping cross panel of DNA samples from 190 F2 individuals. Nearly 4000 SSLPs were genotyped, yielding a 2886-marker genetic map consisting of 10 major linkage groups between 73 and 132cM in length, and 4 smaller linkage groups between 7 and 40cM. The total effective size of the map is 1658cM, and the average intermarker distance for each linkage group ranged from 0.27 to 0.75cM. Fluorescence In Situ Hybridization (FISH) was carried out using probes for genes located on mapped scaffolds to assign linkage ...
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Description: The library was made from dT primed cDNA and cloned into vector pCS107. PolyA RNA were primed with an oligo dT primer (5-GACTAGTTCTAGATCGCGAGCGGCCGCCCTTTTTTTTTTTTTTT -3), ligated to a SalI adapter (5-TCGACCCACGCGTCCG-3 and 5-CGGACGCGTGGG-3) and digested with NotI. cDNA was size selected using 1.1% agarose gel electrophoresis (>0.6kb) then ligated into NotI and SalI digested pCS107 vector. Primary library, non-amplified. Library constructed at the DOE Joint Genome Institute (Walnut Creek, CA) as part of the Xenopus Gene Collection project. ...
... and the human pathogens Candida albicans and Candida tropicalis. Parasexuality has become a useful tool for industrial ... "Parasexuality and Ploidy Change in Candida tropicalis." Eukaryotic Cell. 2013 Dec; 12(12): 1629-1640. Alexopoulos CJ, Mims CW, ... "Completion of a parasexual cycle in Candida albicans by induced chromosome loss in tetraploid strains." EMBO J. 2003 May 15;22( ...
"Repeat-Associated Fission Yeast-Like Regional Centromeres in the Ascomycetous Budding Yeast Candida tropicalis". PLOS Genetics ... Candida albicans and Candida dubliniensis". Proceedings of the National Academy of Sciences. 105 (50): 19797-19802. doi:10.1073 ... Chromosome segregation Candida albicans India portal Biology portal Medicine portal "Faculty - JNCASR". www.jncasr.ac.in. 3 ... Sanyal, K; Carbon, J (1 October 2002). "The CENP-A homolog CaCse4p in the pathogenic yeast Candida albicans is a centromere ...
MA Al-Fattani & LJ Douglas (Aug 2006). "Biofilm matrix of Candida albicans and Candida tropicalis: chemical composition and ... It is marketed as an enzymatic remedy to treat the yeast infection candida. Having the status of a dietary supplement, its ... Masuoka, J (April 2004). "Surface Glycans of Candida albicans and Other Pathogenic Fungi". Clinical Reviews of Microbiology. 17 ... but there is no mention of cellulose nor is cellulose mentioned as a cell wall component in candida albicans, the yeast strain ...
It is now produced by fermentation of long-chain alkanes with a specific strain of Candida tropicalis. Traumatic acid is its ... Brassylic acid can be produced from erucic acid by ozonolysis but also by microorganisms (Candida sp.) from tridecane. This ...
A second analysis of cauim made from rice and manioc also showed the presence of yeasts, chiefly Candida tropicalis. Drink ...
Paraffin wax can be converted into DDDA with a special strain of Candida tropicalis yeast in a multi-step process. Renewable ...
... gene from the yeast Candida tropicalis, with CYP Symbol CYP52A1. Ortiz-Álvarez, J; Becerra-Bracho, A; Méndez-Tenorio, A; Murcia ... gene from the yeast Candida tropicalis: identification of a new P450 gene family". Gene. 76 (1): 121-36. doi:10.1016/0378-1119( ...
Candida glabrata, Candida tropicalis, Candida parapsilosis, Candida krusei and Cryptococcus neoformans. A methanolic extract ... Leaf extracts strongly affect the fungi causing oral candidiasis and skin infections - Candida albicans, ...
Candida tropicalis, Candida glabrata, Candida parapsilosis, Candida krusei, or other species (Candida stellatoidea, Candida ... pseudotropicalis, Candida famata, Candida rugosa, Candida geotrichium, Candida dubliniensis, and Candida guilliermondii). C. ... More Candida is detected in the early morning and the late afternoon. The greatest quantity of Candida species are harbored on ... Oral carriage of Candida is pre-requisite for the development of oral candidiasis. For Candida species to colonize and survive ...
... candida albicans MeSH B05.381.147.400 - candida glabrata MeSH B05.381.147.800 - candida tropicalis MeSH B05.381.170 - ... candida albicans MeSH B05.930.176.400 - candida glabrata MeSH B05.930.176.800 - candida tropicalis MeSH B05.930.316 - ...
... vaginitis caused by proliferation of Candida albicans, Candida tropicalis, Candida krusei Bacterial vaginosis: vaginitis caused ... The yeast Candida albicans is the most common cause of vaginitis. Specific forms of vaginal inflammation include the following ... such as gonorrhea and candida infection) Vaginitis is often caused by an infection or the disruption of the healthy vaginal ...
Other Candida species that also fit this profile are C. parapsilosis, C. glabrata, C. tropicalis, C. guillermondii and C. ... Candida krusei is a budding yeast (a species of fungus) involved in chocolate production. Candida krusei is an emerging fungal ... Candida krusei is a very interesting type of fungus due to the fact that patients that obtain this fungus, result in the lowest ... Pfaller MA, Diekema DJ, Gibbs DL, Newell VA, Nagy E, Dobiasova S, Rinaldi M, Barton R, Veselov A (2008). "Candida krusei, a ...
"Candida glabrata, Candida parapsilosis and Candida tropicalis: biology, epidemiology, pathogenicityand antifungal resistance". ... Unlike Candida albicans and Candida tropicalis, C. parapsilosis is not an obligate human pathogen, having been isolated from ... "Comparison of Candida parapsilosis, Candida orthopsilosis, and Candida metapsilosis adhesive properties and pathogenicity". ... "Prevalence and Distribution Profiles of Candida parapsilosis, Candida orthopsilosis and Candida metapsilosis Responsible for ...
Other medically important species include C. parapsilosis, C. tropicalis, C. dubliniensis. and the more recent upcoming ... Candida mesorugosa, Candida neorugosa, Candida pseudorugosa, Candida ranongensis, Candida rugosa and Candida scorzettiae to the ... Candida antarctica and Candida rugosa are a source of industrially important lipases, while Candida krusei is prominently used ... For example, Candida glabrata, Candida guilliermondii, and Candida lusitaniae are clearly misclassified and will be placed in ...
... may refer to: Caenorhabditis tropicalis, a species of nematodes Candida tropicalis, a yeast species Cryptotis ... Belize and Guatemala All pages with titles containing Tropicalis This disambiguation page lists articles associated with the ... tropicalis, the tropical small-eared shrew, a very small mammal species found in Mexico, ...
This will be varied with different effluents.[10] Effluents can be first processed by a strain of yeast Candida tropicalis JKS2 ... Candida tropicalis Jks2 -Tio2/Uv. Iranian Journal of Environmental Health Science & Engineering 2012, 9 (33), 1-7. ...
Candida species such as C. albicans, C. glabrata, C. krusei, C. tropicalis, C. parapsilosis, and C. guillermondiiare the most ... Linear gingival erythema is classified as a candida-associated lesion, that is to say Candida species are involved, and in some ...
... tropicalis. Antifungal activity is observed for sequential incubation of Candida with lactoferrin and then with fluconazole, ... Candida albicans could also be completely eradicated with a mixture containing lactoferrin, lysozyme and itraconazole in HIV- ... Lactoferrin also acts against the Candida albicans - a diploid fungus (a form of yeast) that causes opportunistic oral and ... Fluconazole has long been used against Candida albicans, which resulted in emergence of strains resistant to this drug. However ...
Candida liik Candida krusei. liik Candida lambica. liik Candida tropicalis. liik Candida utilis. suguk. Saccharomycodaceae. ... Candida albicans, Cryptococcus neoformans, C. tropicalis, C. stellatoidea, C. glabrata, C. krusei, C. parapsilosis, C. ... guilliermondii, C. viswanathii, C. lusitaniae, Rhodotorula mucilaginosa, Candida glabrata, Torulopsis glabrata, C. ... Stoyan T, Carbon J. (2004). "Inner Kinetochore of the pathogenic yeast Candida glabrata". Eukaryotic Cell 3 (5): 1154-1163. doi ...
... tropicalis.[55] Antifungal activity is observed for sequential incubation of Candida with lactoferrin and then with fluconazole ... Candida albicans could also be completely eradicated with a mixture containing lactoferrin, lysozyme and itraconazole in HIV- ... However, a combination of lactoferrin with fluconazole can act against fluconazole-resistant strains of Candida albicans as ... In particular, synthetic peptide 1-11 lactoferricin shows much greater activity against Candida albicans than native ...
It is caused by Candida albicans, Candida glabrata or Candida tropicalis. Signs[change , change source]. Candida may appear as ... It is a fungal infection (mycosis). The disease is caused by any of the Candida species of yeast. Candida albicans is the most ... Odds FC (1987). "Candida infections: an overview". Crit Rev Microbiol. 15: 1-5.. PMID 3319417. ... Candida yeasts are common in most people. The yeast is usually controlled in the body. When the yeast grows without control, an ...
... especially Candida tropicalis, are common, but are not as efficient.[5][7] ...
Candida parapsilosis, human pathogen (2009) Candida orthopsilosis'', human pathogen (2012) Candida tropicalis, human pathogen ( ... Candida albicans Strain:SC5314, human pathogen (2004) Candida albicans Strain:WO-1, human pathogen (2009) Candida dubliniensis ... Candida guilliermondii, human pathogen (2009) Candida lusitaniae, human pathogen (2009) ... May 2004). "The diploid genome sequence of Candida albicans". Proceedings of the National Academy of Sciences of the United ...
Candida tropicalis, C. krusei and C. parapsilosis is increasing, perhaps because significant use of fluconazole is common or ... The most commonly known pathogen is Candida albicans, causing roughly 70% of fungemias, followed by Candida glabrata with 10%, ... New emerging pathogen: Candida auris is an emerging multidrug-resistant (MDR) yeast that can cause invasive infections and is ... The most common type, also known as candidemia, candedemia, or systemic candidiasis, is caused by Candida species, but ...
Candida glabrata is the second most common Candida pathogen after C. albicans, causing infections of the urogenital tract, and ... tropicalis, C. stellatoidea, C. glabrata, C. krusei, C. parapsilosis, C. guilliermondii, C. viswanathii, C. lusitaniae, and ... Most were members of the genus Candida; the most common species in honey stomachs was Dekkera intermedia and in flower ... Species of yeasts found in the tea can vary, and may include: Brettanomyces bruxellensis, Candida stellata, Schizosaccharomyces ...
Candida glabrata is the second most common Candida pathogen after C. albicans, causing infections of the urogenital tract, and ... tropicalis, C. stellatoidea, C. glabrata, C. krusei, C. parapsilosis, C. guilliermondii, C. viswanathii, C. lusitaniae, and ... Most were members of the genus Candida; the most common species in honey bee stomachs was Dekkera intermedia, while the most ... Most were members of the genus Candida; the most common species in honey stomachs was Dekkera intermedia and in flower ...
1914 - Europe C. candida (Rostk.) Hollós 1902 C. capensis (Lloyd) J.C.Coetzee, Eicker & A.E.van Wyk 2003 C. connivens M.Lange ... tropicalis (Speg.) Speg. 1919 C. turneri (Ellis & Everh.) Demoulin & M.Lange 1990 C. utriformis (Bull.) Jaap 1918 C. vinosa ...
Candida tropicalis fungus chocolate [1] Candida utilis fungus cheese [4] Candida valida[10] fungus bread (sourdough) [6] ... a b c NOTE: Candida mycoderma, Candida valida, and/or Candida vini are sometimes listed as a starter culture for wine, but this ... "The lipolytic properties of Candida mycoderma and Debaryomyces kloeckeri isolated from Limburger cheese and some properties of ... Candida exiguus fungus bread (sourdough) Candida humicola fungus chocolate [1] Candida kefyr fungus cheese (surface-ripened) [4 ...
... candida R. canescens R. capitata R. capucina R. celerivirescens R. cettoi R. cinereocarnea R. cladoniae R. clarobrunnea R. ... tropicalis R. tsugina R. valdiviana R. varians R. velocimutans R. verlotensis R. vinaceipes R. vinosimaculans R. ...
Candida albicans 'i (18 tüve) jt Candida sp. (12 tüve) ja 35 liiki dermatofüüdi suhtes.[29] ... and quercetin in a murine model of Blomia tropicalis induced asthma, DARU Journal of Pharmaceutical Sciences 2015, 23:18, doi: ... Hariliku sibula eeterlikud õlid toimivad Aspergillus niger, Cladosporium werneckii, Candida albicans, Fusarium oxysporium, ...
Primary infection, although poorly understood due to lack of data, is thought to occur through inhalation of the conidia through the respiratory tract, after inhaling fungal conidia produced by the mycelial form of P. brasiliensis.[10][16] This occurs predominantly in childhood and young adulthood, after exposure to agricultural activity.[9] Infection may occur through direct skin inoculation, although this is rare.[11] After inhalation into the alveoli, there is rapid multiplication of the organism in the lung tissue, sometimes spreading via the venous and lymphatic systems.[10] Approximately 2% of people develop clinical features after the initial asymptomatic infection.[11] The type of immune response determines the clinical manifestation of the infection, with children and HIV co-infected individuals most commonly developing the acute/subacute disseminated disease.[10] Most of those infected develop a Type 1 T-cell (Th1) mediated immune response, resulting in alveolitis and compact granuloma ...
Candida glabrata is the second most common Candida pathogen after C. albicans, causing infections of the urogenital tract, and ... tropicalis, C. stellatoidea, C. glabrata, C. krusei, C. parapsilosis, C. guilliermondii, C. viswanathii, C. lusitaniae, and ... Most were members of the Candida genus; the most common species in honey stomachs was Dekkera intermedia and in flower ... Species of yeasts found in the tea can vary, and may include: Brettanomyces bruxellensis, Candida stellata, Schizosaccharomyces ...
... (also known as "rose gardener's disease"[1]) is a disease caused by the infection of the fungus Sporothrix schenckii.[2] This fungal disease usually affects the skin, although other rare forms can affect the lungs, joints, bones, and even the brain. Because roses can spread the disease, it is one of a few diseases referred to as rose-thorn or rose-gardeners' disease.[3] Because S. schenckii is naturally found in soil, hay, sphagnum moss, and plants, it usually affects farmers, gardeners, and agricultural workers.[2] It enters through small cuts and abrasions in the skin to cause the infection. In case of sporotrichosis affecting the lungs, the fungal spores enter through the respiratory pathways. Sporotrichosis can also be acquired from handling cats with the disease; it is an occupational hazard for veterinarians. Sporotrichosis progresses slowly - the first symptoms may appear 1 to 12 weeks (average 3 weeks) after the initial exposure to the fungus. Serious complications can ...
Candida albicans (Candidiasis, Oral, Esophageal, Vulvovaginal, Chronic mucocutaneous, Antibiotic candidiasis, Candidal ... tropicalis · C. lusitaniae · Pneumocystis jirovecii (Pneumocystosis, Pneumocystis pneumonia) ...
Harvem põhjustavad haigusi Candida tropicalis, Candida parapsilosis, Candida guilliermondii ja Candida krusei. Need seened on ... Kaks kõige tavalisemat kandidoosiga seostatud liiki on Candida albicans ja Candida glabrata. ... võib kujuneda Candida infektsioon. Lisaks orofarüngeaalsele infektsioonile võib Candida põhjustada vaginaalset infektsiooni.[11 ... Candida spp. esinemine on üldjoontes indiviidile kasulik, kuna seenerakud tunnevad ära ja hävitavad organismis invasiivseid ...
usually Candida albicans and other Candida species Capillariasis Intestinal disease by Capillaria philippinensis, hepatic ...
Toxoplasmosis is becoming a global health hazard as it infects 30-50% of the world human population. Clinically, the life-long presence of the parasite in tissues of a majority of infected individuals is usually considered asymptomatic. However, a number of studies show that this 'asymptomatic infection' may also lead to development of other human pathologies. ... The seroprevalence of toxoplasmosis correlated with various disease burden. Statistical associations does not necessarily mean causality. The precautionary principle suggests however that possible role of toxoplasmosis as a triggering factor responsible for development of several clinical entities deserves much more attention and financial support both in everyday medical practice and future clinical research ...
Rapid in office testing can be done with scraping of the nail, skin, or scalp. Characteristic hyphae can be seen interspersed among the epithelial cells. Trichophyton tonsurans, the causative agent of tinea capitis (scalp infection) can be seen as solidly packed arthrospores within the broken hairshafts scraped from the plugged black dots of the scalp.. Fungal culture medium is used for positive identification of the species. Usually fungal growth is noted in 5 to 14 days. Microscopic morphology of the micro- and macroconidia is the most reliable identification character, but a good slide preparation is needed, and also needed is the stimulation of sporulation in some strains. Culture characteristics such as surface texture, topography and pigmentation are variable so they are the least reliable criteria for identification. Clinical information such as the appearance of the lesion, site, geographic location, travel history, animal contacts and race is also important, especially in identifying ...
Recent debate has centered on whether the Basidiobolaceae should be included in the Entomophthorales, or raised to ordinal status. Molecular systematics approaches so far give an ambiguous answer. Some analyses suggest the Basdiobolaceae are more closely related to certain chytrid fungi than to the Entomophthorales.[3] Others find weak support to maintain them in the Entomophthorales.[4] Morphological characters can be found to support either hypothesis. ...
Not every hospital in the USA is required to publicize details of infectious outbreaks which occur within their facilities. In 2014, details of a lethal mucormycosis outbreak[13] which occurred in 2008 emerged after television and newspaper reports responded to an article in a pediatric medical journal.[14] Contaminated hospital linen was found to be spreading the infection. A cluster of infections occurred in the wake of the 2011 Joplin tornado. As of July 19, a total of 18 suspected cases of cutaneous mucormycosis had been identified, of which 13 were confirmed. A confirmed case was defined as 1) necrotizing soft-tissue infection requiring antifungal treatment or surgical debridement in a person injured in the tornado, 2) with illness onset on or after May 22 and 3) positive fungal culture or histopathology and genetic sequencing consistent with a Mucormycete. No additional cases related to that outbreak have been reported since June 17. Ten patients required admission to an intensive-care ...
For patients who are unresponsive to fluconazole, options are limited. Several case reports have studied the efficacy of three newer antifungal agents in the treatment of disease that is refractory to first-line therapy: posaconazole and voriconazole (triazole compounds similar in structure to fluconazole) and caspofungin (glucan synthesis inhibitor of the echinocandin structural class). However, these drugs have not been FDA approved, and clinical trials are lacking. Susceptibility testing of Coccidioides species in one report revealed uniform susceptibility to most antifungal agents, including these newer drugs. In very severe cases, combination therapy with amphotericin B and an azole have been postulated, although no trials have been conducted. Caspofungin in combination with fluconazole has been cited as beneficial in a case report of a 31-year-old Asian patient with coccidioidal pneumonia. In a case report of a 23-year-old Black male with HIV and coccidioidal meningitis, combination ...
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Candida tropicalis ATCC ® 750™ Designation: [1909, ATCC 4563, ATCC 7349, CBS 94, CCRC 20520, IFO 1070, IFO 1400, JCM 1541, NRRL ... Candida tropicalis multidrug resistance protein (MDR1) gene, Nucleotide (GenBank) : AF218992 Candida tropicalis strain ATCC ... Candida tropicalis alkane-inducible cytochrome P450 gene, complete Nucleotide (GenBank) : U00675 Candida tropicalis D- ... Nucleotide (GenBank) : M60308 C. tropicalis small subunit ribosomal RNA. Nucleotide (GenBank) : M23673 Candida tropicalis (ATCC ...
Candida tropicalis ATCC ® 13803™ Designation: FDA PCI M-59 Application: Assay of amphotericin B fungizone Assay of nystatin ... Candida tropicalis (Castellani) Berkhout (ATCC® 13803™) Strain Designations: FDA PCI M-59 / Product Format: freeze-dried ... Nucleotide (GenBank) : AF201686 Candida tropicalis agglutinin-like protein 1 (ALST1) gene, partial ... Nucleotide (GenBank) : AF211865 Candida tropicalis strain ATCC 13803 agglutinin-like protein Alst2p ...
Proteasome - Candida tropicalis [ Pathway menu , Organism menu , Pathway entry , Download KGML , Show description , User data ...
"Isolation and nucleotide sequence of the extracellular acid protease gene (ACP) from the yeast Candida tropicalis.". Togni G., ... sp,Q00663,CARP_CANTR Candidapepsin OS=Candida tropicalis OX=5482 GN=SAPT1 PE=1 SV=1 ... Candida tropicalis (Yeast). ,p>This subsection of the ,a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names ...
Proteogenomics of Candida tropicalis--An Opportunistic Pathogen with Importance for Global Health.. Datta KK1,2, Patil AH1,2, ... Candida tropicalis is an opportunistic pathogen that causes candidiasis, for example, in immune-compromised individuals, cancer ... Proteogenomics of Candida tropicalis-An Opportunistic Pathogen with Importance for Global Health ... Proteogenomics of Candida tropicalis-An Opportunistic Pathogen with Importance for Global Health ...
XR of molecular mass 36.6 kDa from Candida tropicalis was crystallized using the hanging-drop vapour-diffusion method. ... Purification, crystallization and preliminary X-ray crystallographic analysis of xylose reductase from Candida tropicalis.. ... Purification, crystallization and preliminary X-ray crystallographic analysis of xylose reductase from Candida tropicalis ... Purification, crystallization and preliminary X-ray crystallographic analysis of xylose reductase from Candida tropicalis ...
... isolated from Candida tropicalis; amino acid sequence in first source; GenBank X88900 ... Candida tropicalis SIS2 protein: regulates expression of sodium-extrusion ATPase encoded by ENA1; ... Candida tropicalis SIS2 protein. Subscribe to New Research on Candida tropicalis SIS2 protein ... regulates expression of sodium-extrusion ATPase encoded by ENA1; isolated from Candida tropicalis; amino acid sequence in first ...
sp,C5M4D4,CHO2_CANTT Phosphatidylethanolamine N-methyltransferase OS=Candida tropicalis (strain ATCC MYA-3404 / T1) OX=294747 ... Candida tropicalis (strain ATCC MYA-3404 / T1) (Yeast). ,p>This subsection of the ,a href="http://www.uniprot.org/help/names_ ... Candida/Lodderomyces clade › CandidaCandida tropicalis ... Candida tropicalis (strain ATCC MYA-3404 / T1) (Yeast). Status ...
Search results for Candida tropicalis. A partial match was found for candida tropicalis Please try browsing our store to find ...
... the prevalence of Candida tropicalis as a causative agent of candidiasis has increased. In C. albicans, the ability to switch ... However, studies on C. tropicalis morphogenesis are limited. In this minireview, we discuss the regulation of the yeast-hypha ... For decades, Candida albicans has been one of the most prevalent human fungal pathogens, and recently, ... Conserved and Divergent Functions of the cAMP/PKA Signaling Pathway in Candida albicans and Candida tropicalis ...
We evaluated isolates from 344 patients with an initial episode of C. tropicalis candidemia. We found that 58 (16.9%) patients ... Our findings suggest cross-boundary expansion of FNS C. tropicalis and highlight the importance of active surveillance of ... Candida tropicalis is the leading cause of non-C. albicans candidemia in tropical Asia and Latin America. ... were infected by fluconazole-nonsusceptible (FNS) C. tropicalis with cross resistance to itraconazole, voriconazole, and ...
Resistance to flucytosine is rarely described for this species but was observed for 45 (35%) of 130 C. tropicalis isolates ... tropicalis isolates, is widespread in the Paris area. We propose the analysis of 2 polymorphic microsatellite markers coupled ... Candida tropicalis is a diploid ascomycetes yeast responsible for 4%-24% of candidemia. ... Candida tropicalis is a diploid ascomycetes yeast commonly found on the skin and in digestive tracts of healthy human hosts ...
... tropicalis strains with diverse virulences. C. tropicalis exhibited strain-dependent filamentation ability, which was ... tropicalis strains with diverse virulences. C. tropicalis exhibited strain-dependent filamentation ability, which was ... Based on the phenotypes of C. tropicalis in our previous study, we selected nine representative strains with different ... Based on the phenotypes of C. tropicalis in our previous study, we selected nine representative strains with different ...
Candida tropicalis,/italic, and ,italic,Bacillus firmus,/italic,. Disperse dyes are chiefly used by textile industries for the ... Biological decolorization of industrial dyes by Candida .... Biological decolorization of industrial dyes by Candida tropicalis ... Candida tropicalis. and Bacillus firmus. isolated respectively from contaminated soil samples and sludge of a domestic sewage ...
In contrast, we show that in the related pathogen C. tropicalis white cells are capable of sexual mating and that the white- ... We therefore propose that C. tropicalis Wor1 has retained the ancestral role of this family of transcription factors while also ... Despite these differences, switching in both C. tropicalis and C. albicans is dependent on the expression of the Wor1 ... We show that, in addition to regulating the white-opaque switch in C. tropicalis, Wor1 expression also promotes filamentation ...
The particular species involved were Candida parapsilosis, Candida tropicalis, Candida glabrata, Candida krusei, Candida ... Candida krusei, Candida parapsilosis species complex and Candida tropicalis causing invasive candidiasis in China: 3 year ... Candida tropicalis, Candida glabrata species complex and Candida krusei... ... Renal Candida tropicalis abscesses in a patient with acute lymphoblastic leukemia. Li, W.-Y.; Wu, V.-C.; Lin, W.-C.; Chen, Y.-M ...
... and review the literature on Candida osteomyelitis. METHODS: PubMed was searched for cases of Candida osteomyelitis published ... We present a case of bilateral polymicrobial osteomyelitis with Candida tropicalis and Candida krusei, ... OBJECTIVES: We present a case of bilateral polymicrobial osteomyelitis with Candida tropicalis and Candida krusei, and review ... Bilateral polymicrobial osteomyelitis with Candida tropicalis and Candida krusei: a case report and an updated literature ...
Contribution of the Platelia Candida-Specific Antibody and Antigen Tests to Early Diagnosis of Systemic Candida tropicalis ... Contribution of the Platelia Candida-Specific Antibody and Antigen Tests to Early Diagnosis of Systemic Candida tropicalis ... Contribution of the Platelia Candida-Specific Antibody and Antigen Tests to Early Diagnosis of Systemic Candida tropicalis ... Contribution of the Platelia Candida-Specific Antibody and Antigen Tests to Early Diagnosis of Systemic Candida tropicalis ...
Candida tropicalis derived from ATCC® 1369™*, SKU: 01036KKWIK-STIK™ 6 PackDETAILS ...
C. tropicalis is taxonomically close to C. albicans and shares many pathogenic traits. C. tropicalis is particularly virulent ... Physicians in regions where C. tropicalis is common need to be mindful of this lesser-described pathogen. ... Candida tropicalis is one of the more common Candida causing human disease in tropical countries; the frequency of invasive ... Candida tropicalis in human disease.. @article{Chai2010CandidaTI, title={Candida tropicalis in human disease.}, author={Louis Y ...
One of the Candida species, C. tropicalis, is likely to form biofilms and is also an independent risk factor with high ... Kawai, A., Yamagishi, Y. and Mikamo, H. (2017) Candida tropicalis Biofilm Formation and Efficacy of Liposomal Amphotericin B ... Non-albicans Candida species are increasing gradually in recent clinical practices.. ReTweet if useful… Treatment of candida ... Bloodstream infections caused by Candida species is often associated with the ability of Candida to form biofilms by using ...
We report a methodology for the isolation of peroxisome membranes from the yeast Candida tropicalis pK233 grown on oleic acid, ... Isolation and characterization of membranes from oleic acid-induced peroxisomes of Candida tropicalis ... Isolation and characterization of membranes from oleic acid-induced peroxisomes of Candida tropicalis ... Isolation and characterization of membranes from oleic acid-induced peroxisomes of Candida tropicalis ...
Candida arthritis in patients with a haematological malignancy is rare. We report a case of Candida tropicalis arthritis of the ... Although the Candida tropicalis isolates from synovial fluid and synovial tissue were sensitive to fluconazole in vitro, a 6- ... Candida tropicalis arthritis of the knee in a patient with acute lymphoblastic leukaemia: successful treatment with caspofungin ... Eleven other reports of Candida arthritis in patients with a haematological malignancy were reviewed. ...
Candida tropicalis isolates often display reduced but persistent growth (trailing) over a broad fluconazole concentration range ... Implications of the EUCAST Trailing Phenomenon in Candida tropicalis for the In Vivo Susceptibility in Invertebrate and Murine ... Implications of the EUCAST Trailing Phenomenon in Candida tropicalis for the In Vivo Susceptibility in Invertebrate and Murine ... Implications of the EUCAST Trailing Phenomenon in Candida tropicalis for the In Vivo Susceptibility in Invertebrate and Murine ...
Comparison of in vivo activity of fluconazole with that of amphotericin B against Candida tropicalis, Candida glabrata, and ... Comparison of in vivo activity of fluconazole with that of amphotericin B against Candida tropicalis, Candida glabrata, and ... Comparison of in vivo activity of fluconazole with that of amphotericin B against Candida tropicalis, Candida glabrata, and ... Comparison of in vivo activity of fluconazole with that of amphotericin B against Candida tropicalis, Candida glabrata, and ...
"In vitro effects of promethazine on cell morphology and structure and mitochondrial activity of azole-resistant Candida ... tropicalis, Medical Mycology" on DeepDyve, the largest online rental service for scholarly research with thousands of academic ... Candida glabrata, Candida parapsilosis and Candida tropicalis: biology, epidemiology, pathogenicity and antifungal resistance ... Candida glabrata, Candida parapsilosis and Candida tropicalis: biology, epidemiology, pathogenicity and antifungal resistance ...
View Candida tropicalis Z012, DNA (1 µg) 0801538DNA-1UG from our online collection of viruses, microorganisms, and other ...
Predominance of Candida tropicalis bloodstream infections in a Singapore teaching hospital. Authors: Chai, Y.A.L.. Wang, Y.. ... Predominance of Candida tropicalis bloodstream infections in a Singapore teaching hospital. Medical Mycology 45 (5) : 435-439. ... A predominant clonal C. tropicalis strain was demonstrated. No association with ICU stay, prior exposure to fluconazole/broad- ... An 18-month epidemiologic investigation of Candida bloodstream infections in a Singapore hospital identified 52 candidemic ...
UV irradiation treatment of the asexual yeast Candida tropicalis gave rise to morphological mutants exhibiting at least four ... Variation of colony morphology and chromosomal rearrangement in Candida tropicalis pK233 * Takahito Suzuki, Yuki Miyamae and ... Summary: UV irradiation treatment of the asexual yeast Candida tropicalis gave rise to morphological mutants exhibiting at ...
Export allele sequences in XMFA/concatenated FASTA formats - Candida tropicalis isolates. This script will export allele ...
  • We evaluated isolates from 344 patients with an initial episode of C. tropicalis candidemia. (cdc.gov)
  • Our findings suggest cross-boundary expansion of FNS C. tropicalis and highlight the importance of active surveillance of clinical isolates to detect dissemination of this pathogen and explore potential sources in the community. (cdc.gov)
  • Some studies of the genetic relationship of clinical fluconazole-nonsusceptible (FNS) C. tropicalis isolates have reported clonal diversity ( 22 - 24 ), whereas others have demonstrated clonal clusters ( 20 , 25 , 26 ). (cdc.gov)
  • Resistance to flucytosine is rarely described for this species but was observed for 45 (35%) of 130 C. tropicalis isolates recovered from blood cultures in the Paris area in a 4-year survey. (cdc.gov)
  • Our results suggest that a clone of flucytosine-resistant isolates, associated with malignancies and a lower mortality than that for other C. tropicalis isolates, is widespread in the Paris area. (cdc.gov)
  • 5% of all Candida species except for C. krusei , in which it is detected in up to 28% of isolates ( 3 ). (cdc.gov)
  • It was thus unexpected to observe 35% resistance to 5FC among C. tropicalis isolates recovered from blood cultures in the active surveillance program on yeast-related fungemia implemented by the French National Reference Center for Mycoses and Antifungals (NRCMA) in the Paris area. (cdc.gov)
  • Clinical isolates of C. tropicalis recovered from blood cultures during the YEASTS program from October 1, 2002, through September 30, 2006, were selected for the study. (cdc.gov)
  • Purpose: To study molecular profiles of oral Candida tropicalis isolates from five different geographic locales to determine the molecular diversity, clonality and evolutionary trends of this opportunistic pathogen. (ebscohost.com)
  • Although the Candida tropicalis isolates from synovial fluid and synovial tissue were sensitive to fluconazole in vitro, a 6-week course of oral treatment failed to produce clinical improvement. (hkmj.org)
  • Candida tropicalis isolates often display reduced but persistent growth (trailing) over a broad fluconazole concentration range during EUCAST susceptibility testing. (asm.org)
  • Because of the increasing importance of infections due to other species of Candida, we studied the efficacy of fluconazole in a rat model of established systemic candidiasis, using clinical isolates of C. tropicalis, C. glabrata, and C. Krusei. (asm.org)
  • Further in vivo studies are needed, however, to define minimum effective doses and length of therapy and to test additional Candida isolates. (asm.org)
  • Three C. tropicalis isolates (two azole-resistant and one azole-susceptible) were evaluated for their planktonic and biofilm susceptibility to promethazine alone and in combination with itraconazole, fluconazole, voriconazole, amphotericin B, and caspofungin. (deepdyve.com)
  • Promethazine, Candida tropicalis, azole resistance, synergism, biofilm Introduction C. tropicalis is frequently isolated from patients with candidiasis, and it currently is the first or second most frequent non-Candida albicans Candida species involved in cases of candidemia and candiduria.1 Azole resistance in C. tropicalis has been frequently reported,2 especially among clinical isolates,3-5 including those showing cross-resistance to azole antifungals. (deepdyve.com)
  • Methods Isolates Three C. tropicalis strains, two azole-resistant and one azole-susceptible, from urine, bronchoalveolar lavage, and tracheal aspirate, respectively, were used in this study. (deepdyve.com)
  • Identification of infecting strains of Candida is important because isolates of Candida species differ widely, both in their ability to cause infection and also in their susceptibility to antifungal agents. (hindawi.com)
  • In this study, we investigated the clinical features, azole resistance and genetic relatedness of 87 C. tropicalis isolates from central China and combined with the global database to explore the relationship between genetic information and fluconazole susceptibility. (cdc.gov)
  • This study was designed to determine whether burn might influence the species distribution and susceptibilities of azoles against clinical isolates of Candida species including C. tropicalis. (bvsalud.org)
  • A total 372 Candida isolates from various samples in a tertiary burn center were studied, and the MICs of Candida isolates to fluconazole , itraconazole , and voriconazole were tested by broth microdilution method of the Clinical and Laboratory Standards Institute (CLSI) M27-A2. (bvsalud.org)
  • A comparison was made between Candida isolates from burn patients and non- burn patients . (bvsalud.org)
  • The percentages of C. albicans, C. tropicalis, C. parapsilosis and C. glabrata isolates from burn patients and non- burn patients were 42.3% and 64.2% (P=0.000), 35.7% and 21.6% (P=0.002), 11.9% and 7.8%, and 10.1% and 6.4%, respectively. (bvsalud.org)
  • ERG11 sequencing was performed for azole-resistant Candida isolates. (beds.ac.uk)
  • The MIC50 and MIC90 values [mg/l] of antifugal agents for Candida albicans, Candida glabrata, Candida tropicalis, Candida krusei and Candida kefyr isolates. (elsevier.es)
  • The aim of this study was to evaluate the genetic relatedness between Candida albicans , Candida glabrata , Candida tropicalis , Candida krusei and Candida kefyr isolates recovered from intensive care unit (ICU) patients. (elsevier.es)
  • Candida albicans isolates were 100% sensitive to all antifungal agents tested, whereas Candida krusei and Crytococcus neoformans displayed intermediate resistance to 5-flucytosine, with Minimal Inhibitory Concentration (MIC) values of 8 mg/mL and 16 mg/mL, respectively. (scielo.br)
  • In 2004, 52 recent isolates of Candida species were obtained from clinical specimens sent to the Medical Microbiology Laboratory, University College Hospital, Ibadan, Nigeria. (nih.gov)
  • Recently, the prevalence of non- albicans Candida species (NACs)-such as C. tropicalis , C. glabrata , and C. parapsilosis -in patients with candidiasis or candidemia has increased [ 4 , 5 ]. (mdpi.com)
  • The widespread use of azoles during the past 2 decades coincided with a decrease in incidence of C. tropicalis and C. albicans infections, which was coupled with an increase in infections caused by C. glabrata and other less susceptible and azole-resistant Candida species ( 12 , 15 , 16 ). (cdc.gov)
  • A multicenter study conducted in this region found that the 90% (MIC 90 ) of fluconazole for C. tropicalis increased to 32 µg/mL, the same as the MIC 90 of C. glabrata and much higher than the MIC 90 of C. albicans , 0.064 µg/mL ( 19 ). (cdc.gov)
  • Antifungal susceptibilities of Candida glabrata species complex, Candida krusei, Candida parapsilosis species complex and Candida tropicalis causing invasive candidiasis in China: 3 year national surveillance. (ebscohost.com)
  • Methods We evaluated the susceptibilities to nine antifungal drugs of Candida parapsilosis species complex, Candida tropicalis, Candida glabrata species complex and Candida krusei. (ebscohost.com)
  • Comparison of in vivo activity of fluconazole with that of amphotericin B against Candida tropicalis, Candida glabrata, and Candida krusei. (asm.org)
  • In normal rats, oral fluconazole at both 20 and 80 mg/kg per day for 7 days reduced both kidney and liver titers of C. tropicalis and C. glabrata compared with those in control animals and was only slightly inferior to amphotericin B. Both fluconazole and amphotericin B were ineffective in reducing kidney titers of C. krusei, but amphotericin B was more effective than fluconazole in reducing liver titers. (asm.org)
  • An 18-month epidemiologic investigation of Candida bloodstream infections in a Singapore hospital identified 52 candidemic patients: 36% of whose infections were caused by C. tropicalis, 29% were due to C. albicans, 10% with C. parapsilosis and 21% involved C. glabrata. (nus.edu.sg)
  • W posiewie krwi obwodowej i krwi z cewnika centralnego wyhodowano dwa szczepy z rodzaju Candida - Candida tropicalis i Candida glabrata . (evereth.pl)
  • Zgodnie z wytycznymi IDSA, ESCMID oraz rekomendacji grup eksperckich w leczeniu fungemii i fungemii odcewnikowych o etiologii Candida tropicalis i Candida glabrata lekami pierwszego rzutu są echinokandyny. (evereth.pl)
  • Echinocandins are the drugs of choice in therapy of fungaemia and catheter-related fungal bloodstream infections of Candida tropicalis and Candida glabrata etiology, in accordance with the guidelines of the IDSA, ESCMID as well as expert groups' recommendations. (evereth.pl)
  • Candida tropicalis (19/66) was the main cause of candidemia in these seven hospitals, followed by Candida parapsilosis (18/66) , Candida albicans (18/66), and Candida glabrata (7/66). (beds.ac.uk)
  • Candida parapsilosis was isolated mainly from the hands of HCWs (7/28), and various yeasts were collected from high-touch areas (11/47), including Naganishia albida, C. parapsilosis and C. glabrata . (beds.ac.uk)
  • others were Candida glabrata (nine), Candida tropicalis (seven), Candida parapsilosis (seven), Candida stellatoidea (six), and Candida krusei (six). (nih.gov)
  • Abstract The purpose of this study was to investigate the production of flavor compounds from olive mill waste by microbial fermentation of Rhizopus oryzae and Candida tropicalis . (bvsalud.org)
  • Bilateral polymicrobial osteomyelitis with Candida tropicalis and Candida krusei: a case report and an updated literature review. (biomedsearch.com)
  • OBJECTIVES: We present a case of bilateral polymicrobial osteomyelitis with Candida tropicalis and Candida krusei, and review the literature on Candida osteomyelitis. (biomedsearch.com)
  • Between 3 weeks and 6 months after hospitalization, he developed bilateral osteomyelitis of the feet with C. tropicalis and C. krusei. (biomedsearch.com)
  • The current name of Candida krusei and Issatchenkia orientalis is Pichia kudriavzevii Boidin et al. (atcc.org)
  • In this context, the aim of this study was to evaluate the antifungal activity of thymol against Candida albicans, Candida tropicalis and Candida krusei strains and to determine its mode of action and synergistic effect when combined with the synthetic antifungal nystatin. (springer.com)
  • Thymol presented an antifungal effect, with MICs of 39 μg/mL for C. albicans and C. krusei and 78 μg/mL for C. tropicalis . (springer.com)
  • We report a methodology for the isolation of peroxisome membranes from the yeast Candida tropicalis pK233 grown on oleic acid, and the characterization of the polypeptide and lipid compositions of these membranes. (biologists.org)
  • Summary: UV irradiation treatment of the asexual yeast Candida tropicalis gave rise to morphological mutants exhibiting at least four different types of abnormal colonies on glucose-containing solid medium. (microbiologyresearch.org)
  • Aims: The objective of this study was to determine the interactions between common spoilage yeast, Candida tropicalis, isolated from ultrafiltration membranes, and Escherichia coli O157:H7 and Salmonella sp. (conicet.gov.ar)
  • Live cells of phenol-degrading yeast, Candida tropicalis RETL-Cr1, were immobilized on coconut husk and loofah by adsorption. (ums.edu.my)
  • The n-alkane-assimilating diploid yeast, Candida tropicalis, possesses two acetoacetyl-CoA thiolase (Thiolase I) isozymes encoded by one allele: peroxisomal and cytosolic Thiolase Is encoded by both CT-T1A and CT-T1B. (elsevier.com)
  • Ueda, M , Kanayama, N & Tanaka, A 2000, ' Genetic Evaluation of Peroxisomal and Cytosolic Acetoacetyl-CoA Thiolase Isozymes in n-Alkane-Assimilating Diploid Yeast, Candida tropicalis ', Cell Biochemistry and Biophysics , vol. 32, pp. 285-290. (elsevier.com)
  • Continuous treatment of Acid Red B (ARB) with activated sludge (AS) bioaugmented by an azo-degrading yeast Candida tropicalis TL-F1 under aerobic conditions was investigated in the form of sequencing batch tests. (environmental-expert.com)
  • C. tropicalis and C. albicans are ascomycetous diploid yeasts, closely related among pathogenic Candida species, and belong in a single Candida clade characterized by the unique translation of CUG codons as serine rather than leucine ( 6 , 7 ). (cdc.gov)
  • Characterization of the interactions between human high-molecular-mass kininogen and cell wall proteins of pathogenic yeasts Candida tropicalis. (semanticscholar.org)
  • After a cumulative dose of 7200 cGy some virulence attributes of C. tropicalis , including macro and micromorphological characteristics, adhesion and biofilm abilities, murine experimental infection and phagocytosis resistance were evaluated on irradiated and non-irradiated yeasts. (biomedcentral.com)
  • Our findings show for the first time that C. tropicalis, one of the most important yeasts from colonization, which cause fatal candidemia in cancer patients, is affected by gamma irradiation, with changes to its virulence profile. (biomedcentral.com)
  • Medically important yeasts of the genus Candida secrete aspartic proteinases (Saps), which are of particular interest as virulence factors. (asm.org)
  • These results indicate that the pathogenic yeasts C. albicans and C. tropicalis recognize distinct RGD ligands present at the surface of the epithelial cell and that these interactions can be differentially inhibited by defined RGD peptides con-taining appropriate flanking sequences. (umn.edu)
  • Total 24 yeasts were isolated from the soil samples of near by distillery site, in which isolate Y-9 showed maximum decolorization and identified as Candida tropicalis by Microbial Type Culture Collection (MTCC) Chandigarh, India. (biomedcentral.com)
  • Berkhout (7) was concerned about Candida yeasts existing in nature as well as about species found in men as saprophytic or parasites that were isolated from the skin, oral cavity, intestines and urogenital system. (scielo.br)
  • Candida yeasts can be the agents of local or systemic opportunistic infections, mainly in hospitalized patients, especially those under intensive treatment (1). (scielo.br)
  • Based on the phenotypes of C. tropicalis in our previous study, we selected nine representative strains with different activities of virulence factors (adhesion, biofilm formation, secreted aspartic proteinases, and hemolysins), and one reference strain, ATCC750. (frontiersin.org)
  • The present study aimed to investigate the filamentation ability, the expression of virulence genes ( ALST1-3, LIP1, LIP4 , and SAPT1-4 ) and the cell damage of C. tropicalis strains with diverse virulences. (frontiersin.org)
  • Culture of the blood samples obtained from the peripheral vein and through the central venous catheter revealed two strains of Candida spp. (evereth.pl)
  • On the basis of the results obtained it was found the highest increase of yeast biomass in the case of the application of two strains of yeast: Candida utilis and Candida tropicalis by cultivation process on rye stillage. (edu.pl)
  • This study was done to detect the presence of ALS genes by PCR in C.tropicalis strains isolated from HIV and non-HIV patients in comparison with biofilm formation. (springer.com)
  • This study aimed to evaluate the in vitro antifungal susceptibility profile and production of virulence factors in strains of C. tropicalis (n=100) isolated from several animal species. (ufc.br)
  • Regarding the susceptibility of C. tropicalis strains, 38% were resistant to itraconazole, 40% were resistant to fluconazole and 34% were resistant to both azoles. (ufc.br)
  • To investigate the antifungal effects of the hit compounds, ASTs were conducted using Candida strains in various growth modes, including biofilms. (frontiersin.org)
  • Four of the compounds identified, BAY11-7082, BAY11-7085, sanguinarine chloride hydrate and ellipticine, had toxic effects on Candida strains and hGF cells. (frontiersin.org)
  • In contrast, CV-3988 had fungicidal effects on Candida strains, but low cytotoxic effects on hGF cells. (frontiersin.org)
  • Objectives To define the antifungal susceptibility patterns of the most common non-albicans Candida spp. (ebscohost.com)
  • This study is the first to reveal a significant correlation between genetic information and fluconazole susceptibility worldwide and to trace geographical locations, which is of great value for molecular epidemiological surveillance and azole-resistance study of C. tropicalis globally. (cdc.gov)
  • Techniques for antifungal susceptibility testing of Candida albicans biofilms. (springer.com)
  • Standardized method for in vitro antifungal susceptibility testing of Candida albicans biofilms. (springer.com)
  • For decades, Candida albicans has been one of the most prevalent human fungal pathogens, and recently, the prevalence of Candida tropicalis as a causative agent of candidiasis has increased. (mdpi.com)
  • Candida species are the leading fungal pathogens causing severe healthcare-associated infections in immunocompromised patients globally ( 1 ). (cdc.gov)
  • Candida species account for 10 to 15% of all hospital-acquired bloodstream pathogens. (asm.org)
  • The potential to undergo a parasexual cycle under laboratory conditions has been demonstrated in many species of filamentous fungi, including Fusarium monoliforme, Penicillium roqueforti (used in making blue cheeses), Verticillium dahliae, Verticillium alboatrum, Pseudocercosporella herpotrichoides, Ustilago scabiosae, Magnaporthe grisea, Cladosporium fulvum, and the human pathogens Candida albicans and Candida tropicalis. (wikipedia.org)
  • Candida species are the fourth leading cause of nosocomial bloodstream infections and have one of the highest mortality rates among nosocomial pathogens. (bvsalud.org)
  • Candida species have emerged as important and common opportunistic human pathogens, particularly in immunocompromised individuals. (frontiersin.org)
  • Over the last decades, Candida species have emerged as important pathogens in immunocompromised patients. (elsevier.es)
  • Candida tropicalis is the leading cause of non- C. albicans candidemia in tropical Asia and Latin America. (cdc.gov)
  • C. tropicalis is among the top 4 Candida species responsible for candidemia worldwide and is the most common cause of invasive candidiasis in tropical Asia and in Latin America ( 2 - 5 ). (cdc.gov)
  • Candida tropicalis is a diploid ascomycetes yeast responsible for 4%-24% of candidemia. (cdc.gov)
  • Infections caused by C. tropicalis are reported in 4%-24% of patients with candidemia, depending on the country of study, underlying risk factors, and period of study ( 2 ). (cdc.gov)
  • Our data thus confirm the value of the combined detection of mannanemia and antimannan antibodies in individuals at risk of candidemia and suggest that in neutropenic patients, an approach based on the regular monitoring of both markers could contribute to the earlier diagnosis of C. tropicalis systemic infection. (asm.org)
  • Candida species bloodstream infection such as candidemia remains a significant with high morbidity and mortality. (ivteam.com)
  • No association with ICU stay, prior exposure to fluconazole/broad-spectrum antibiotics or increased mortality was found in this apparent shift towards non-C. albicans Candida species as the primary agents of candidemia. (nus.edu.sg)
  • Candida tropicalis is an important cause of candidemia in immunocompromised patients. (springer.com)
  • C. tropicalis, por exemplo, tem sido associada à cadidíases invasivas graves, sendo a primeira ou segunda espécie de Candida não-albicans mais comumente isolada em candidemia e candidúria em humanos, além de ser frequentemente isolada da microbiota de animais saudáveis e com candidíase. (ufc.br)
  • C. tropicalis, for example, has been associated with serious invasive cadidiases, being the first or second type of non-Candida albicans Candida most commonly isolated in humans with candidemia and candiduria and is frequently isolated from healthy animals and animals with candidiasis. (ufc.br)
  • It is a member of the non-albicans group of Candida that are known to be azole-resistant, and is frequently seen in individuals being treated for cancers, HIV-infection, and those who underwent bone marrow transplantation. (nih.gov)
  • Lactate dehydrogenase assays showed that the cell damage induced by C. tropicalis markedly increased with longer infection time (24 and 48 h). (frontiersin.org)
  • Candidiasis is a fungal infection due to Candida. (familysymptoms.com)
  • The growing importance of Candida is in part related to the emergence of HIV infection and the more widespread use of immunosuppressive chemotherapy. (hindawi.com)
  • C. tropicalis has been reported to be one of the leading Candida species other than C. albicans to cause Candida infection in patients who have malignancy , diabetes mellitus , and burn . (bvsalud.org)
  • To establish infection, C. tropicalis expresses many virulence factors such as the secretion of enzymes phospholipases and proteases, biofilm production, among others. (ufc.br)
  • Candidiasis is an infection caused by a yeast species of the genus Candida , which belongs to the family Cryptococcaceae. (scielo.br)
  • Yilmaz O, Celik S. A combination of alpha-tocopherol, vitamin C and N-acetyl cysteine increases unsaturated fatty acid levels in hydrogen peroxide-induced Candida tropicalis (ATCC 13803). (atcc.org)
  • Describes an incident of community-acquired Candida tropicalis fungemia where the patients remained candidemic despite high-dose fluconazole therapy. (ebscohost.com)
  • Fluconazole (UK-49,858) is a new oral bis-triazole antifungal agent with demonstrated activity against Candida albicans. (asm.org)
  • These biofilms produced more matrix material than those grown statically, and were significantly more resistant to amphotericin B. Biofilms of C. tropicalis synthesized large amounts of matrix material even when grown statically, and such biofilms were completely resistant to both amphotericin B and fluconazole. (microbiologyresearch.org)
  • The high prevalence of C. tropicalis joined by fluconazole-resistance may hamper the therapeutic efficacy of fluconazole, the frontline antifungal drug used in Algeria. (beds.ac.uk)
  • It is noteworthy that coconut oil was active against species of Candida at 100% concentration compared to fluconazole. (nih.gov)
  • The antifungal activity of promethazine against C. tropicalis was investigated by performing time-kill curve assays and assessing rhodamine 6G efflux, cell size/granularity, membrane integrity, and mitochondrial transmembrane potential, through flow cytometry. (deepdyve.com)
  • In conclusion, promethazine presented synergy with azole antifungals against resistant C. tropicalis and exhibited in vitro cytotoxicity against C. tropicalis, altering cell size/granularity, membrane integrity, and mitochondrial function, demonstrating potential mechanisms of cell damage against this yeast species. (deepdyve.com)
  • Comparison of biofilms formed by Candida albicans and Candida parapsilosis on bioprosthetic surfaces. (springer.com)
  • Characterization of agglutinin-like sequence genes from non- albicans Candida and phylogenetic analysis of the ALS family. (atcc.org)
  • CAMPOS-TAKAKI, G. M. Characterization, surface properties and biological activity of a biosurfactant produced from industrial waste by Candida sphaerica UCP0995 for application in the petroleum industry. (blucher.com.br)
  • SARUBBO, L. A. Characterization and properties of the biosurfactant produced by Candida lipolytica UCP 098 Electronic J. Biotech. (blucher.com.br)
  • We report here on the identification and characterization of novel 2-enoyl thioester reductases of fatty acid metabolism, Etr1p from Candida tropicalis and its homolog Ybr026p (Mrf1′p) from Saccharomyces cerevisiae . (vtt.fi)
  • Among these studies, few examined the association between genetic relatedness of FNS C. tropicalis and clinical characteristics and outcomes of the infected patients ( 23 , 27 ). (cdc.gov)
  • Non-albicans Candida species are increasing gradually in recent clinical practices. (ivteam.com)
  • Among species of the Candida genus, C. albicans has received the most clinical attention, including studies on the pathophysiology of IFI. (biomedcentral.com)
  • Candida tropicalis is a globally distributed human pathogenic yeast, and its increasing resistance to azoles makes clinical treatment difficult. (cdc.gov)
  • Bendel, CM , Hosteller, MK & McClellan, M 1993, ' Distinct mechanisms of epithelial adhesion for candida albicans and candida tropicalis identification of the participating ligands and development of inhibitory peptides ', Journal of Clinical Investigation , vol. 92, no. 4, pp. 1840-1849. (umn.edu)
  • Pretreatment of sugarcane bagasse hemicellulose hydrolysate for xylitol production by Candida guilliermondii. (ipb.ac.id)
  • clarification needed] C. parapsilosis is encountered more frequently in nature than other species Candida, likely because it is one of the few species of the genus not restricted to humans. (wikipedia.org)
  • There are over 200 known species of the genus Candida , but only a relatively small number of Candida are pathogenic to humans ( Chander, 2009 ). (scielo.br)
  • Several yeast species of Candida genus can colonize the skin as well as the mucous membrane of the vagina and the digestive tract for short or long periods. (scielo.br)
  • The genus Candida was created during the IX International Botanical Congress, held in Canada in 1959, and substituted the term Monilia, used until then (58). (scielo.br)
  • Candida species are common causative agents of superficial and invasive fungal infections worldwide [ 1 , 2 ]. (mdpi.com)
  • In recent years there has been a significant increase in the incidence of fungal infections caused by Candida species. (ufc.br)
  • The incidence of fungal infections due to Candida spp. (scielo.br)
  • Coconut oil should be used in the treatment of fungal infections in view of emerging drug-resistant Candida species. (nih.gov)
  • This study was conducted to investigate the process of biofilm formation by C. tropicalis and the antifungal activity of liposomal amphotericin B (LAB) against both forming-biofilms and developed-biofilms using time-lapse imaging" Kawai et al (2017). (ivteam.com)
  • Kawai, A., Yamagishi, Y. and Mikamo, H. (2017) Candida tropicalis Biofilm Formation and Efficacy of Liposomal Amphotericin B using time-lapse images. (ivteam.com)
  • To our knowledge, this is the first high-throughput proteomics study of C. tropicalis validating predicted protein coding genes and refining the current genome annotation. (nih.gov)
  • C. tropicalis exhibited strain-dependent filamentation ability, which was positively correlated with biofilm formation. (frontiersin.org)
  • A predominant clonal C. tropicalis strain was demonstrated. (nus.edu.sg)
  • According to this study, the highest ethanol amount was obtained about 0.43 % (v/v) with an ethanol yield of 2.51 % and theoretical yield of 4.92 % by fermentation of sugarcane bagasse hydrolysate with detoxification using the adapted strain of C. tropicalis at 72 hours fermentation time. (ipb.ac.id)
  • Proteogenomics of Candida tropicalis--An Opportunistic Pathogen with Importance for Global Health. (nih.gov)
  • Candida tropicalis is an opportunistic pathogen that causes candidiasis, for example, in immune-compromised individuals, cancer patients, and those who undergo organ transplantation. (nih.gov)
  • Candida tropicalis , an emerging opportunistic pathogen, mainly causes superficial and invasive infections in human populations, especially among neutropenic patients and those with hematological malignancies ( Guinea, 2014 ). (frontiersin.org)
  • In recent years there has been an increased interest in infections caused by the opportunistic pathogen Candida . (hindawi.com)
  • M35199 C. tropicalis NADPH-cytochrome P450 reductase gene, complete cds. (atcc.org)
  • Azole resistance in C. tropicalis results from the overexpression and/or mutation in the ERG11 gene that encodes the cytochrome P450 lanosterol 14α-demethylase,6 the primary target for azoles. (deepdyve.com)
  • Using the gene SAPT1 as a probe and under low-stringency hybridization conditions, three new closely related gene sequences, SAPT2 to SAPT4 , encoding secreted proteinases were cloned from a C. tropicalis λEMBL3 genomic library. (asm.org)
  • All bands identified by Southern blotting of Eco RI-digested C. tropicalis genomic DNA with SAPT1 could be assigned to a specific SAP gene. (asm.org)
  • Therefore, the SAPT gene family of C. tropicalis is likely to contain only four members. (asm.org)
  • Interestingly, the SAPT2 and SAPT3 gene products, Sapt2p and Sapt3p, which have not yet been detected in C. tropicalis cultures in vitro, were produced as active recombinant enzymes with the methylotrophic yeast Pichia pastoris as an expression system. (asm.org)
  • Here we report on the cloning of a Candida tropicalis gene, ETR2, that is closely related to ETR1. (vtt.fi)
  • Ethanol has been reported to cause mycelial growth in Candida tropicalis Pk233, and mycelial growth has also been shown to be abolished by concomitant addition of myo -inositol. (microbiologyresearch.org)
  • We conducted a study of 334 patients with C. tropicalis bloodstream infections (BSIs) in Taiwan to examine these relationships in greater detail. (cdc.gov)
  • Bloodstream infections caused by Candida species is often associated with the ability of Candida to form biofilms by using medical devices, such as central venous catheters. (ivteam.com)
  • Central venous catheter-related bloodstream infections of fungal etiology may be of endogenous (majority of cases of Candida spp. (evereth.pl)
  • Candia tropicalis is an increasingly important human pathogen, causing nosocomial fungemia among patients with neutropenia or malignancy. (frontiersin.org)
  • The transition of Candida from a harmless commensal to a pathogenic organism is complex and is related to subtle environmental changes that lead to expression of a range of virulence factors (Table 2 ). (hindawi.com)
  • Among NACs, C. tropicalis is the first or second most commonly isolated species from patients with candidiasis, especially in tropical regions such as Brazil and Asia [ 6 , 7 , 8 , 9 , 10 ]. (mdpi.com)
  • Caspofungin use in patients with invasive candidiasis caused by common non-albicans Candida species: review of the caspofungin database. (ebscohost.com)
  • In this study, 212 patients with candidiasis caused by non-albicans Candida spp. (ebscohost.com)
  • The diagnosis of candidiasis was based on a positive blood culture (all seven patients) and the isolation of C. tropicalis from a normally sterile site (six patients). (asm.org)
  • and non -Candida albicans species of Candida , although they may have a lower intrinsic pathogenic potential than C. albicans , are now identified in more than 45% of episodes of hematogenously disseminated candidiasis ( 30 , 44 ). (asm.org)
  • C. parapsilosis is the most common non-C. albicans species of Candida and the second most common pathogen in superficial candidiasis after C. albicans. (wikipedia.org)
  • The Platelia Candida -specific antigen and antibody assays (Bio-Rad Laboratories) were used to test serial serum samples from seven neutropenic adult patients with hematological malignancies who had developed systemic Candida tropicalis infections. (asm.org)
  • Comparison of three assays for the quantification of Candida biomass in suspension and CDC reactor grown biofilms. (springer.com)
  • Reverse transcriptase PCR analysis showed that the ALST3 and SAPT3 genes had the highest expression in their corresponding genes for most C. tropicalis . (frontiersin.org)
  • ALS 2 and ALS 3 genes were more common in C.tropicalis than ALS 1. (springer.com)
  • Furthermore, at least two families of multidrug transporters are involved in the development of azole resistance in Candida spp. (deepdyve.com)
  • Azole resistance mechanisms in C. albicans, C. parapsilosis , and C. tropicalis is mediated mainly by the occurrence of specific amino acid substitutions in ERG11 , resulting in reduced affinity of azoles to the drug target, in addition to overexpression of efflux pumps [ 7 ]. (beds.ac.uk)
  • Candida tropicalis yeast is a microorganism that possesses high tolerance for phenol and strong phenol degrading activity. (cuni.cz)
  • Statistical experimental designs were used to optimize the process of phenol degradation by Candida tropicalis Z-04, isolated from phenol-degrading aerobic granules. (jesc.ac.cn)
  • This study indicated the excellent ability of C. tropicalis Z-04 in degrading high-strength phenol. (jesc.ac.cn)
  • Various techniques are available for the isolation of Candida within the oral cavity. (hindawi.com)
  • prior colonization with Candida spp. (asm.org)
  • The colonization of C. tropicalis on stainless steel surfaces was reduced when it was co-cultivated with both pathogenic bacteria, reducing C. tropicalis population by at least 1·0 log unit. (conicet.gov.ar)
  • In vitro activity of caspofungin against Candida albicans biofilms. (springer.com)
  • Purification, crystallization and preliminary X-ray crystallographic analysis of xylose reductase from Candida tropicalis. (nih.gov)
  • Candida parapsilosis is a fungal species of yeast that has become a significant cause of sepsis and of wound and tissue infections in immunocompromised people. (wikipedia.org)
  • METHODS: PubMed was searched for cases of Candida osteomyelitis published in the English-language literature between 1970 and 2010. (biomedsearch.com)
  • The aim of this study is develop new small-molecule antifungal compounds by library screening methods using Candida albicans , and to evaluate their antifungal effects on Candida biofilms and cytotoxic effects on human cells. (frontiersin.org)
  • It could be stated with that neither the superficial nor the systemic forms of Candida infections could be initiated in the absence of underlying pathology [ 2 ]. (hindawi.com)
  • The spores of Candida are a commensal, harmless form of a dimorphic fungus that becomes invasive and pathogenic pseudohyphae when there is a disturbance in the balance of flora or in debilitation of the host [ 1 ]. (hindawi.com)
  • CONCLUSIONS: Candida osteomyelitis should be considered when a patient presents with risk factors and pain without previous trauma, because Candida, despite being part of the normal flora, is the fourth leading cause of hematogenous nosocomial infections. (biomedsearch.com)
  • Immunoblotting with an antiserum to PMP 24 showed that PMP 24 segregates with the peroxisome membrane fractions and is induced by growth of Candida tropicalis on oleic acid. (biologists.org)
  • C. albicans is a human commensal organism and is rarely found in the environment, whereas C. tropicalis is not only a commensal of the human oral cavity, but is also present in soil, compost, plants, beaches, and seawater in tropical or subtropical areas [ 11 , 12 , 13 , 14 ]. (mdpi.com)
  • Candida and Cryptococcus fungi, which belong to the Saccharomycetaceae and Tremellaceae families, respectively are the most medically important yeast species ( Hazen and Howell, 2007 ). (scielo.br)
  • Most cases of Candida osteomyelitis are caused by Candida albicans, but an increasing number are caused by non-albicans species. (biomedsearch.com)
  • Effect of growth rate on resistance of Candida albicans biofilms to antifungal agents. (microbiologyresearch.org)
  • Candida albicans biofilms on most medical devices are exposed to a flow of body fluids that provide water and nutrients to the fungal cells. (springer.com)
  • Production of extracellular matrix by Candida albicans biofilms. (springer.com)