Candida glabrata
Candida
Candida albicans
Candidiasis
Drug Resistance, Fungal
Antifungal Agents
Fluconazole
Echinocandins
Fungemia
Drug Resistance, Multiple, Fungal
Candida tropicalis
Microbial Sensitivity Tests
Amphotericin B
Mycology
Gene Expression Regulation, Fungal
Candidiasis, Invasive
Candidiasis, Oral
Peptides, Cyclic
Itraconazole
Histatins
Ergosterol
Culture Media
Fungi
Sterol 14-Demethylase
Yeasts
Colony Count, Microbial
Glucosyltransferases
Schistosoma mansoni
Chromogenic Compounds
Candidiasis, Cutaneous
Trichosporon
Molecular Sequence Data
Pyrimidines
Genes, Mating Type, Fungal
Random Amplified Polymorphic DNA Technique
Saccharomyces cerevisiae
Copper Sulfate
Mouth
Cryptococcus
Ketoconazole
Virulence
Sterols
Species Specificity
Echinostoma
Agar
Phenotypic switching and filamentation in Candida glabrata. (1/351)
Candida glabrata switches spontaneously, reversibly and at high frequency among the following four phenotypes distinguishable by graded colony colouration on CuSO(4)-containing agar: white (Wh), light brown (LB), dark brown (DB) and very dark brown (vDB). These phenotypes also differ in a graded fashion in the level of expression of the metallothionein gene MTII (WhEndogenous reactive oxygen species is an important mediator of miconazole antifungal effect. (2/351)
We investigated the significance of endogenous reactive oxygen species (ROS) produced by fungi treated with miconazole. ROS production in Candida albicans was measured by a real-time fluorogenic assay. The level of ROS production was increased by miconazole at the MIC (0.125 micro g/ml) and was enhanced further in a dose-dependent manner, with a fourfold increase detected when miconazole was used at 12.5 micro g/ml. This increase in the level of ROS production was completely inhibited by pyrrolidinedithiocarbamate (PDTC), an antioxidant, at 10 micro M. In a colony formation assay, the decrease in cell viability associated with miconazole treatment was significantly prevented by addition of PDTC. Moreover, the level of ROS production by 10 clinical isolates of Candida species was inversely correlated with the miconazole MIC (r = -0.8818; P < 0.01). These results indicate that ROS production is important to the antifungal activity of miconazole. (+info)Prospective, multicenter surveillance study of Candida glabrata: fluconazole and itraconazole susceptibility profiles in bloodstream, invasive, and colonizing strains and differences between isolates from three urban teaching hospitals in New York City (Candida Susceptibility Trends Study, 1998 to 1999). (3/351)
Since the 1990s, the substantial increase in the rate of Candida glabrata infections has become a serious problem. As most C. glabrata infections arise from the host's endogenous microflora, the present prospective, multicenter analysis included all clinical isolates associated with colonization and with systemic and hematogenous candidiasis. Among 347 C. glabrata isolates, the overall rates of resistance to fluconazole (MIC > or = 64 micro g/ml) and itraconazole (MIC > or = 1 micro g/ml) were 10.7 and 15.2%, respectively, although for half (n = 148) of the itraconazole-susceptible isolates the MICs (0.25 to 0.5 micro g/ml) were in the susceptible-dependent upon dose range. Fluconazole resistance was more common among C. glabrata isolates obtained from centers caring for patients with cancer (MICs at which 90% of isolates are inhibited [MIC(90)s] = 32 micro g/ml) or AIDS (MIC(90)s > 64 micro g/ml) than among C. glabrata isolates from a community-based university medical center (MIC(90)s = 16 micro g/ml) (P = 0.001). Thirty-three bloodstream isolates and those obtained from other body sites had similar in vitro susceptibility profiles. The fluconazole MIC(90)s (< or =16 micro g/ml) for C. glabrata yeast isolates from the gastrointestinal tract were lower than those (> or =64 micro g/ml) for C. glabrata isolates from respiratory and urinary tract samples (P = 0.01). A similar discrepancy for itraconazole was not significant (P > 0.5). We did not observe differences in fluconazole or itraconazole susceptibility profiles among C. glabrata isolates associated with either hematogenous dissemination or colonization. The significant discrepancy in antifungal susceptibility among C. glabrata organisms isolated from hospitals in the same geographic region emphasizes the significance of periodic susceptibility surveillance programs for individual institutions, especially those providing care to patients at risk. (+info)Candida glabrata ATP-binding cassette transporters Cdr1p and Pdh1p expressed in a Saccharomyces cerevisiae strain deficient in membrane transporters show phosphorylation-dependent pumping properties. (4/351)
The expression and drug efflux activity of the ATP binding cassette transporters Cdr1p and Pdh1p are thought to have contributed to the recent increase in the number of fungal infections caused by Candida glabrata. The function of these transporters and their pumping characteristics, however, remain ill defined. We have evaluated the function of Cdr1p and Pdh1p through their heterologous hyperexpression in a Saccharomyces cerevisiae strain deleted in seven major drug efflux transporters to minimize the background drug efflux activity. Although both Cdr1p- and Pdh1p-expressing strains CDR1-AD and PDH1-AD acquired multiple resistances to structurally unrelated compounds, CDR1-AD showed, in most cases, higher levels of resistance than PDH1-AD. CDR1-AD also showed greater rhodamine 6G efflux and resistance to pump inhibitors, although plasma membrane fractions had comparable NTPase activities. These results indicate that Cdr1p makes a larger contribution than Phd1p to the reduced susceptibility of C. glabrata to xenobiotics. Both pump proteins were phosphorylated in a glucose-dependent manner. Whereas the phosphorylation of Cdr1p affected its NTPase activity, the protein kinase A-mediated phosphorylation of Pdh1p, which was necessary for drug efflux, did not. This suggests that phosphorylation of Pdh1p may be required for efficient coupling of NTPase activity with drug efflux. (+info)Identification of Candida glabrata by a 30-second trehalase test. (5/351)
Rapid (30-s) trehalase tests done with material from colonies of 482 yeasts suspended in a drop of trehalose solution on a commercially supplied glucose test strip were positive for 225 (99.1%) of 227 Candida glabrata isolates grown on either of two differential media, Candida ID medium or CandiSelect medium. The test was positive for only 3 (1.2%) and 12 (4.7%) of 255 isolates of other medically important yeast species grown on the same two media, respectively. A rapid maltase test done with a subset of 255 yeast isolates was negative for all but 1 of 64 trehalase-positive C. glabrata isolates, raising the specificity of the rapid testing for C. glabrata to 98.4 to 100%, depending on the isolation medium used. Rapid trehalase and maltase tests done independently in two laboratories with 217 yeast isolates showed sensitivities of 96.0 to 98.0% and specificities of 98.2 to 99.4% for identification of C. glabrata from colonies grown on Candida ID medium. The specificity was much lower because of frequent false-positive trehalose test results when the source of colonies was Sabouraud agar formulated with 4% glucose. We conclude that direct recognition of C. albicans as blue colonies on Candida ID isolation medium coupled with the performance of the 30-s trehalase and maltase tests for C. glabrata among the white colonies on this medium will allow the rapid presumptive identification of the two yeast species most commonly encountered in clinical samples. (+info)Prospective evaluation of Candida species colonization in hospitalized cancer patients: impact on short-term survival in recipients of marrow transplantation and patients with hematological malignancies. (6/351)
Most hematogenous candidiasis originates from endogenous host flora. The impact of clinically prominent Candida colonization on short-term mortality (The complete mitochondrial genome sequence of the pathogenic yeast Candida (Torulopsis) glabrata. (7/351)
We report here the complete sequence of the mitochondrial (mt) genome of the pathogenic yeast Candida glabrata. This 20 kb mt genome is the smallest among sequenced hemiascomycetous yeasts. Despite its compaction, the mt genome contains the genes encoding the apocytochrome b (COB), three subunits of ATP synthetase (ATP6, 8 and 9), three subunits of cytochrome oxidase (COX1, 2 and 3), the ribosomal protein VAR1, 23 tRNAs, small and large ribosomal RNAs and the RNA subunit of RNase P. Three group I introns each with an intronic open reading frame are present in the COX1 gene. This sequence is available under accession number AJ511533. (+info)Multiple patterns of resistance to fluconazole in Candida glabrata isolates from a patient with oropharyngeal candidiasis receiving head and neck radiation. (8/351)
Candida glabrata has emerged in recent years as a significant cause of systemic fungal infection. We have previously reported on the first three patients receiving radiation for head and neck cancer to develop oropharyngeal candidiasis due to C. glabrata. The goal of this study was to track the development of increased fluconazole resistance in C. glabrata isolates and to evaluate previously described genetic mechanisms associated with this resistance from one of these three patients. The patient was a 52-year-old man with squamous cell carcinoma treated with radiation. At week 7 of his radiation, he developed oropharyngeal candidiasis, which was treated with 200 mg of fluconazole daily for 2 weeks. Serial cultures from this and three subsequent time points yielded C. glabrata. Isolates from these cultures were subjected to antifungal susceptibility testing, DNA karyotyping, and evaluation of the expression of genes previously associated with C. glabrata resistance to fluconazole, CgCDR1, CgCDR2, and CgERG11. Two strains (A and B) of C. glabrata were identified and found to display different patterns of resistance development and gene expression. Strain A developed resistance over a 2-week period and showed no overexpression of these genes. In contrast, strain B first showed resistance 6 weeks after fluconazole therapy was discontinued but showed overexpression of all three genes. In conclusion, development of resistance to fluconazole by C. glabrata is a highly varied process involving multiple molecular mechanisms. (+info)Types of candidiasis:
1. Vulvovaginal candidiasis (VVC): a common infection that affects the vagina and vulva; symptoms include itching, burning, and abnormal discharge.
2. Oral thrush (OT): an infection that affects the mouth, often seen in infants and people with weakened immune systems; symptoms include white patches on the tongue and inside the cheeks.
3. Invasive candidiasis (IC): a severe infection that can spread throughout the body, often seen in people with weakened immune systems, such as those with HIV/AIDS or undergoing chemotherapy; symptoms include fever, chills, and difficulty breathing.
4. Candidal balanitis: an infection of the foreskin and glans of the penis; symptoms include redness, swelling, and pain.
5. Diaper rash: a common skin infection that affects infants who wear diapers; symptoms include redness, swelling, and irritability.
Causes and risk factors:
1. Overgrowth of Candida fungus due to an imbalance of the normal flora.
2. Use of antibiotics or steroids that can disrupt the balance of the body's natural flora.
3. Weakened immune system, such as in people with HIV/AIDS or undergoing chemotherapy.
4. Poor hygiene and sanitation.
5. Diabetes mellitus.
6. Pregnancy.
7. Obesity.
Diagnosis:
1. Physical examination and medical history.
2. Microscopic examination of a scraping or biopsy specimen.
3. Cultures of skin, blood, or other body fluids.
4. Polymerase chain reaction (PCR) or other molecular diagnostic techniques to detect the presence of the fungus.
Treatment:
1. Topical antifungal medications, such as clotrimazole, miconazole, or terbinafine, applied directly to the affected area.
2. Oral antifungal medications, such as fluconazole or itraconazole, for more severe infections or those that do not respond to topical treatment.
3. Antibiotics if there is a secondary bacterial infection.
4. Supportive care, such as pain management and wound care.
5. Proper hygiene and sanitation practices.
6. In severe cases, hospitalization may be necessary for intravenous antifungal medications and close monitoring.
Prevention:
1. Practice good hygiene and sanitation.
2. Avoid sharing personal items, such as towels or clothing.
3. Wash hands before touching the affected area.
4. Keep the affected area clean and dry.
5. Use of antifungal powders or sprays on the affected area.
6. Avoid using harsh soaps or cleansers that can irritate the skin.
7. Wear shoes in public areas to prevent exposure to fungal spores.
8. Avoid sharing bathing or showering facilities with others.
9. Dry thoroughly after bathing or swimming.
10. Use of antifungal medications as a prophylactic measure in high-risk individuals, such as those with weakened immune systems.
It's important to note that the best treatment and prevention strategies will depend on the specific type of fungus causing the infection, as well as the severity and location of the infection. It is essential to consult a healthcare professional for proper diagnosis and treatment.
Symptoms of fungemia may include fever, chills, night sweats, fatigue, and weight loss. Diagnosis is typically made by drawing blood cultures and performing microbiological tests to identify the presence of fungal organisms in the blood. Treatment typically involves administration of antifungal medications, which can be given intravenously or orally. In severe cases, hospitalization may be necessary to monitor and treat the condition.
In some cases, fungemia can lead to complications such as sepsis, organ failure, and death. Prompt diagnosis and treatment are essential to prevent these outcomes.
Candidemia can cause a range of symptoms, including fever, chills, rapid heart rate, and confusion. In severe cases, it can lead to organ failure and death. Treatment typically involves the use of antifungal medications, and in some cases, hospitalization is necessary to manage the infection and monitor the patient's condition.
Preventative measures to reduce the risk of developing candidemia include proper handwashing and hygiene, avoiding close contact with people who are sick, and ensuring that medical equipment and surfaces are properly cleaned and disinfected. Early detection and treatment can significantly improve outcomes for patients with candidemia.
Causes:
The most common cause of candidiasis is an imbalance in the natural bacteria and yeast that live in and around the vagina. This imbalance can be caused by a variety of factors, including:
* Taking antibiotics, which can kill off the "good" bacteria that keep candida in check
* Pregnancy and menopause, when hormonal changes can lead to an overgrowth of yeast
* Diabetes, which can cause excess sugar in the body that feeds the growth of yeast
* Weakened immune system
* Poor hygiene or poor fitting clothing and underwear that can trap moisture and create a warm environment for yeast to grow.
Symptoms:
The symptoms of candidiasis can vary from person to person, but common signs include:
* Itching, burning, and redness of the vulva and vagina
* A thick, white discharge that looks like cottage cheese and has no odor or a mild, sweet smell
* Pain or discomfort during sex
* Difficulty getting pregnant (infertility) if the infection is severe or recurrent.
Diagnosis:
A healthcare provider can diagnose candidiasis by performing a physical examination and taking a sample of vaginal discharge for testing. The provider may also take a culture of the yeast to determine which type of candida is causing the infection.
Treatment:
Candidiasis can be treated with antifungal medications, such as clotrimazole or terconazole. These medications are available over-the-counter or by prescription and come in creams, tablets, or suppositories. To help clear the infection, treatment may also include:
* Avoiding irritants such as douches, powders, or scented soaps
* Wearing loose-fitting clothing and cotton underwear
* Keeping the genital area clean and dry
* Avoiding sex during treatment
Complications:
If left untreated, candidiasis can lead to complications such as:
* Recurrent infections
* Inflammation of the vulva (vulvodynia)
* Inflammation of the vagina (vaginitis)
* Pain during sex
* Difficulty getting pregnant (infertility)
Prevention:
To prevent candidiasis, women can take the following steps:
* Practice good hygiene by washing the genital area gently with soap and water
* Avoid using douches, powders, or scented soaps
* Wear loose-fitting clothing and cotton underwear
* Change out of wet or sweaty clothes as soon as possible
* Avoid sex during treatment for candidiasis.
Prognosis:
With proper treatment, the prognosis for candidiasis is good. The infection usually clears up within a week or two with antifungal medication. However, recurrent infections can be more difficult to treat and may require longer courses of therapy. In some cases, candidiasis can lead to complications such as inflammation of the vulva or vagina, which can be more challenging to treat.
It is important for women to seek medical attention if they experience any symptoms of candidiasis, as early diagnosis and treatment can help prevent complications and improve outcomes.
Candidiasis, invasive is caused by the overgrowth of Candida in the body, which can occur for a variety of reasons, such as:
* Weakened immune system due to HIV/AIDS, cancer, or medications that suppress the immune system.
* Invasive medical devices, such as central lines or implanted pacemakers.
* Previous history of invasive candidiasis.
* Pregnancy.
* Intravenous drug use.
The symptoms of candidiasis, invasive can vary depending on the organs affected, but may include:
* Fever.
* Chills.
* Shortness of breath.
* Pain in the abdomen or chest.
* Confusion or disorientation.
* Skin rash or lesions.
Diagnosis of candidiasis, invasive is based on a combination of physical examination, medical history, and laboratory tests, such as blood cultures and imaging studies. Treatment typically involves the use of antifungal medications, which may be given intravenously or orally, depending on the severity of the infection. In severe cases, hospitalization may be necessary to monitor and treat the infection.
Prevention of candidiasis, invasive includes:
* Proper hygiene and handwashing practices.
* Avoiding close contact with individuals who have invasive candidiasis.
* Avoiding sharing of personal items, such as toothbrushes or razors.
* Avoiding the use of invasive medical devices, if possible.
* Proper care and maintenance of medical devices.
* Monitoring for signs of infection in individuals with weakened immune systems.
In conclusion, candidiasis, invasive is a serious and potentially life-threatening fungal infection that can affect various organs and systems in the body. Early diagnosis and treatment are crucial to prevent complications and improve outcomes. Proper prevention and control measures can help reduce the risk of developing invasive candidiasis.
The infection is usually caused by an overgrowth of Candida, which is a normal flora in the mouth, but can become pathogenic under certain conditions. Risk factors for developing OC include taking antibiotics, wearing dentures, pregnancy, diabetes, and HIV/AIDS.
OC can be diagnosed by examining the mouth and throat with a mirror and torch, as well as through laboratory tests such as cultures or PCR. Treatment typically involves antifungal medication, good oral hygiene practices, and addressing any underlying conditions. In severe cases, hospitalization may be necessary.
Preventative measures include practicing good oral hygiene, avoiding smoking, and managing any underlying medical conditions. In addition, early diagnosis and treatment can help prevent the infection from spreading to other parts of the body, such as the bloodstream or heart.
The most common types of mycoses include:
1. Ringworm: This is a common fungal infection that causes a ring-shaped rash on the skin. It can affect any part of the body, including the arms, legs, torso, and face.
2. Athlete's foot: This is a common fungal infection that affects the feet, causing itching, redness, and cracking of the skin.
3. Jock itch: This is a fungal infection that affects the groin area and inner thighs, causing itching, redness, and cracking of the skin.
4. Candidiasis: This is a fungal infection caused by Candida, a type of yeast. It can affect various parts of the body, including the mouth, throat, and vagina.
5. Aspergillosis: This is a serious fungal infection that can affect various parts of the body, including the lungs, sinuses, and brain.
Symptoms of mycoses can vary depending on the type of infection and the severity of the infection. Common symptoms include itching, redness, swelling, and cracking of the skin. Treatment for mycoses usually involves antifungal medications, which can be applied topically or taken orally. In severe cases, hospitalization may be necessary to monitor and treat the infection.
Preventive measures for mycoses include practicing good hygiene, avoiding sharing personal items such as towels and clothing, and using antifungal medications as prescribed by a healthcare professional. Early diagnosis and treatment of mycoses can help prevent complications and reduce the risk of transmission to others.
The symptoms of candidiasis, cutaneous may include:
* Redness and swelling on the affected area
* Itching and burning sensation
* Thickening and discoloration of the skin
* Cracks or fissures in the skin
Candidiasis, cutaneous can be diagnosed through a physical examination and may require additional tests such as a skin scraping or biopsy to confirm the diagnosis. Treatment typically involves antifungal medications and good wound care. In severe cases, hospitalization may be required.
Prevention is key in avoiding candidiasis, cutaneous. Good hygiene practices such as frequent handwashing, keeping the skin clean and dry, and avoiding sharing personal items can help reduce the risk of infection. Additionally, managing underlying conditions such as diabetes and taking antibiotics only when necessary can also help prevent candidiasis, cutaneous.
Types of Pelvic Infections:
1. Bacterial Vaginosis (BV): A common type of pelvic infection caused by an imbalance of good and harmful bacteria in the vagina.
2. Gonorrhea and Chlamydia: Two sexually transmitted infections that can cause pelvic inflammation and damage to the reproductive organs.
3. Pelvic Inflammatory Disease (PID): A serious infection that can damage the fallopian tubes, ovaries, and other reproductive organs.
4. Endometritis: An infection of the lining of the uterus, which can cause pain and infertility.
5. Salpingitis: Inflammation of the fallopian tubes, which can lead to scarring and blockage of the tubes.
6. Oophoritis: Inflammation of the ovaries, which can cause pain and swelling.
Causes and Risk Factors:
1. Sexually transmitted infections (STIs) such as gonorrhea and chlamydia
2. Unprotected sex
3. Poor hygiene
4. Douching
5. IUDs (intrauterine devices)
6. Pregnancy and childbirth
7. Abortion
8. Pelvic surgery
9. Using non-sterile instruments during pelvic exams
Symptoms:
1. Vaginal discharge that is thick, yellow, or greenish
2. Painful sex
3. Pain in the lower abdomen
4. Fever and chills
5. Heavy menstrual bleeding
6. Painful urination
7. Abdominal tenderness and swelling
Diagnosis:
1. Physical examination
2. Pelvic examination with a speculum
3. Gonorrhea and chlamydia testing
4. Cultures for bacterial infections
5. Imaging tests such as ultrasound or CT scan
6. Laparoscopy (a minimally invasive procedure using a thin tube with a camera and light to examine the pelvic region)
Treatment:
1. Antibiotics for bacterial infections
2. Anti-inflammatory medications for pain relief
3. Surgical intervention for severe cases or if other treatments fail
4. Removal of any foreign objects or blocks in the fallopian tubes
5. Infertility treatment if necessary
Prevention:
1. Practice safe sex using condoms or dental dams
2. Get regular pelvic exams and STI testing
3. Use clean and sterile instruments during pelvic exams
4. Avoid douching
5. Consider getting an IUD that is less likely to cause pelvic inflammation
Complications:
1. Chronic pelvic pain
2. Infertility
3. Ectopic pregnancy (pregnancy outside the uterus)
4. Pelvic abscess (a collection of pus in the pelvis)
5. Septicemia (blood poisoning)
6. Death in severe cases.
Candida glabrata
Yeast
Candida bracarensis
Pteleopsis myrtifolia
Glossary of mycology
Bernard Dujon
Harlequin beetle
Oral mucosa
Fungemia
List of periodontal diseases
Candida albicans
CLEC6A
List of sequenced fungi genomes
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Buddleja
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Vermes in the 10th edition of Systema Naturae
List of data deficient plants
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Oral candidiasis
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Histatin
Aminocandin
Candida (fungus)
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Bet hedging (biology)
Invasive candidiasis
Clausena anisata
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Candida tropicalis
Fluconazole
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Strobilanthes
Candida krusei
Achimenes
Lactoferrin
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Vaginal yeast infection
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Pseudowintera colorata
Heterologous Expression of Full-Length Lanosterol 14α-Demethylases of Prominent Fungal Pathogens Candida albicans and Candida...
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Systematic phenotyping of a large-scale Candida glabrata deletion collection reveals novel antifungal tolerance genes. - INRAE...
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Epidemiology and susceptibility of Nakaseomyces (formerly Candida) glabrata bloodstream isolates from hospitalised adults in...
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Call Transcript: August 15, 2017 | Clinicians Outreach and Outreach Communication (COCA)
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Albicans15
- We have addressed these problems by expressing in Saccharomyces cerevisiae functional, hexahistidine-tagged, full-length Candida albicans LDM (CaLDM6×His) and Candida glabrata LDM (CgLDM6×His) for drug discovery purposes and determining their X-ray crystal structures. (nih.gov)
- Candida albicans and/or Candida tropicalis, Candida parapsilosis, Candida glabrata and/or Candida krusei. (health-innovations.org)
- Moreover, the common fungus responsible for vaginal yeast infection is Candida Albicans. (newshunt360.com)
- In the market based on pathogen type, the candida Albicans is the most common fungus responsible for the yeast infection , which is the segment that holds the major share of the market. (newshunt360.com)
- 6. Candida albicans osteomyelitis in an infant: a case report and literature review. (nih.gov)
- One study found RsAFP2 caused cell death in Candida albicans, a common fungus normally found in humans. (totalhealthmagazine.com)
- When Candida albicans overgrows, it often causes vaginal yeast infections, oral yeast infections (thrush), and invasive candidiasis. (totalhealthmagazine.com)
- Candida albicans was the species most often isolated. (who.int)
- Candida albicans s'est révélé être l'espèce la plus souvent isolée. (who.int)
- If you look here at about 7,000 isolates that we have from our surveillance system within the Emerging Infectious Program here at CDC with state and academic partners, you can see that this pie chart represents the different species that we see and the blue is the classic species of Candida albicans . (cdc.gov)
- Brunke S, Hube B. Two unlike cousins: Candida albicans and C. glabrata infection strategies. (ijccm.org)
- Non-albicans Candida have emerged as important opportunistic pathogens, notably C. tropicalis, C. glabrata, C. parapsilosis and C. krusei. (who.int)
- With the introduction of antifungal agents, the causes of Candida infections shifted from an almost complete dominance of Candida albicans to the common involvement of Candida glabrata and other non-albicans Candida species.METHODSThis prospective, microbiological observational study was conducted in a tertiary care hospital for one and a half years from July 2016 to December 2017. (who.int)
- Candida albicans accounted for 10% and non albicans Candida accounted for 90% of the fungal isolates. (who.int)
- Among the risk factors observed for neonatal candidemia, low birth weight (76.67%) and prematurity (73.33%) were commonest followed by broad spectrum antibiotic use (66.67%), total parenteral nutrition (53.3%), ventilator support (36.67%) and indwelling catheters (26.67%).CONCLUSIONSNon-albicans Candida has emerged as an important pathogen causing neonatal septicaemia. (who.int)
Isolates8
- Epidemiology and susceptibility of Nakaseomyces (formerly Candida) glabrata bloodstream isolates from hospitalised adults in South Africa. (bvsalud.org)
- We aimed to describe the clinical characteristics of adults with N. glabrata candidaemia at 20 sentinel hospitals ( accounting for 20% (172/917) of cases) and the antifungal susceptibility of the corresponding isolates. (bvsalud.org)
- Eight N. glabrata isolates (6%, 8/131) had minimum inhibitory concentrations in the intermediate or resistant range for ≥ 1 echinocandin and a R1377K amino acid substitution encoded by the hotspot 2 region of the FKS2 gene . (bvsalud.org)
- There are no N. glabrata clinical isolates that are considered susceptible to fluconazole , and thus echinocandins are recommended for treatment . (bvsalud.org)
- We described the characteristics of South African patients with N. glabrata bloodstream infections and the antifungal susceptibility of corresponding isolates. (bvsalud.org)
- Only 6% of N. glabrata isolates were echinocandin -resistant with mutations in specific resistance genes that we have found in South African N. glabrata isolates previously. (bvsalud.org)
- Eight percent of N. glabrata isolates were resistant to fluconazole and the remainder were in the susceptible dose dependent category, requiring higher fluconazole treatment doses. (bvsalud.org)
- Frequency of decreased susceptibility and resistance to echinocandins among fluconazole-resistant bloodstream isolates of Candida glabrata. (ijccm.org)
Infections10
- This is due to the overgrowth of candida which causes yeast infections vagina. (newshunt360.com)
- 5. Successful treatment of Candida osteoarticular infections with limited duration of antifungal therapy and orthopedic surgical intervention. (nih.gov)
- Candidemia, which is the bloodstream manifestation of fungal infections due to Candida , turns out in recent studies that we've looked at are the most common if not some of the most common healthcare associated bloodstream infections in our country, in the United States. (cdc.gov)
- The risk factors for candid are sometimes we call in the fungal world the other C. diff , have somewhat similar characteristics in that broad spectrum antibacterial use is a very common association with those who develop infections due to Candida . (cdc.gov)
- As I mentioned, source of infections due to Candida generally we think, and from conventional wisdom, that these are really auto infections with our own host gut flora. (cdc.gov)
- Candida infections like oral thrush occur when a person s immune system becomes weakened by diseases or specific kinds of drugs. (home-remedies-for-you.com)
- Further investigations into risk factors for Candida infections related to the severity of cirrhosis, as well as study into epidemiological shifts and resistance patterns in the Candida species, are necessitated. (esicm.org)
- The treatments used to manage Candida infections vary substantially and are based on the anatomic location of the infection, the patients' underlying disease and immune status, the patients' risk factors for infection, the specific species of Candida responsible for infection, and, in some cases, the susceptibility of the Candida species to specific antifungal drugs. (medscape.com)
- In August 2013, the FDA announced that clinicians should no longer prescribe ketoconazole (Nizoral, Janssen Pharmaceuticals) tablets as a first-line therapy for any fungal infection, including Candida and dermatophyte infections, because of the risk for severe liver injury, adrenal insufficiency, and adverse drug interactions. (medscape.com)
- BACKGROUND Candida species is one of the most common causes of bloodstream infections among neonates and accounts for 9-13% of such infections. (who.int)
Tropicalis1
- The most common type of yeast that leads to the infection is the Candida Alibicans but in some cases, Candida Glabrata or Candida Tropicalis can also cause the infection. (home-remedies-for-you.com)
Parapsilosis1
- We do occasionally see outbreaks mainly with a species called Candida parapsilosis , but these outbreaks are actually very rare. (cdc.gov)
Infection4
- 1. Drug-Resistant Candida glabrata Infection in Cancer Patients, Dimitrios Farmakiotis et al. (cdc.gov)
- One such infection is caused by the fungal organism Candida . (cdc.gov)
- 16. Predictors and outcomes of Candida bloodstream infection: eight-year surveillance, western Saudi Arabia. (nih.gov)
- Oral candidiasis, also commonly referred to as oral thrush, can be described as a yeast infection caused by the genus Candida. (home-remedies-for-you.com)
Fungus1
- Nakaseomyces (formerly Candida ) glabrata is a yeast -like fungus that forms part of the commensal gut flora and among people with certain risk factors , can invade into the bloodstream. (bvsalud.org)
Candidemia2
Resistance2
Susceptibility1
- This study was carried out from October 2003 to March 2007 to investigate susceptibility patterns to antifungals of Candida strains isolated from 410 immunocompromised patients in Shiraz, Islamic Republic of Iran. (who.int)
Organism1
- After his 2-year tour ended, he returned to the United States and attended Johns Hopkins University, where he worked on the AIDS opportunistic disease organism Candida glabrata. (nih.gov)
Echinocandin2
- Patients with confirmed N. glabrata candidaemia are recommended to be treated with an echinocandin (or polyene), thus further guideline training is required. (bvsalud.org)
- Caspofungin MICs correlate with treatment outcomes among patients with Candida glabrata invasive candidiasis and prior echinocandin exposure. (ijccm.org)
Saccharomyces2
- The fate of linear DNA in Saccharomyces cerevisiae and Candida glabrata: the role of homologous and non-homologous end joining. (nih.gov)
- In this study, we investigated the plasmid construction technique called gap repair cloning (GRC) in two closely related species of yeast - Saccharomyces cerevisiae and Candida glabrata. (nih.gov)
Outcomes1
- 3. Treatment and outcomes of Candida osteomyelitis: review of 53 cases from the PATH Alliance® registry. (nih.gov)
Itraconazole1
- For Candida onychomycosis, oral itraconazole (Sporanox) appears to be most efficacious. (medscape.com)
Genes1
- Systematic phenotyping of a large-scale Candida glabrata deletion collection reveals novel antifungal tolerance genes. (inrae.fr)
Species isolated1
- The Candida species isolated were identified using standard mycological techniques. (who.int)
Resistant2
Patients3
- We found that patients infected with N. glabrata were more likely to be older, female , admitted to public hospitals and to be post- surgery and these patients were also more likely to be treated with fluconazole monotherapy and to have stayed a shorter time in hospital compared to patients infected with other Candida species. (bvsalud.org)
- La présente étude, réalisée entre octobre 2003 et mars 2007, a recherché les évolutions de la sensibilité aux antifongiques des souches de Candida isolées chez 410 patients immunodéprimés dans la ville de Chiraz (République islamique d'Iran). (who.int)
- Des analyses régulières de la résistance aux antifongiques dans les centres médicaux sont fortement recommandées, car les résultats permettront une prise en charge plus efficace de la candidose systémique chez les patients immunodéprimés. (who.int)
Common1
- Nakaseomyces glabrata is a relatively more common cause of candidaemia in high- income vs. low- and middle- income countries. (bvsalud.org)
Cases5
- During 2016-2017, Nakaseomyces glabrata (formerly Candida glabrata ) caused 14% of cases of candidaemia in South Africa . (bvsalud.org)
- 1. Candida osteomyelitis: analysis of 207 pediatric and adult cases (1970-2011). (nih.gov)
- 4. Two hundred and eleven cases of Candida osteomyelitis: 17 case reports and a review of the literature. (nih.gov)
- 9. Candida vertebral osteomyelitis (CVO) 28 cases from a 10-year retrospective study in France. (nih.gov)
- 11. Candida Arthritis: Analysis of 112 Pediatric and Adult Cases. (nih.gov)
Data1
- Results from hkgFinder are compared to results from three other popular tools (geNorm, BestKeeper and NormFinder) for azole-stimulated Candida glabrata RT qPCR data. (nih.gov)
Oral2
- Tomar boro por vía oral en dosis más altas posiblemente no sea seguro y se ha relacionado con un menor peso al nacer y defectos congénitos. (medlineplus.gov)
- Es posible que el boro no sea seguro cuando se toma por vía oral en dosis más altas. (medlineplus.gov)
Case1
- 19. Fungal arthritis with adjacent osteomyelitis caused by Candida pelliculosa: a case report. (nih.gov)
Fungal4
- One such infection is caused by the fungal organism Candida . (cdc.gov)
- We pinpoint a single species, the fungal pathogen Candida glabrata, in which a trans mutation has occurred very recently in a single AP-1 family member, distinguishing it from its Saccharomyces ortholog. (nih.gov)
- Candidemia, which is the bloodstream manifestation of fungal infections due to Candida , turns out in recent studies that we've looked at are the most common if not some of the most common healthcare associated bloodstream infections in our country, in the United States. (cdc.gov)
- The risk factors for candid are sometimes we call in the fungal world the other C. diff , have somewhat similar characteristics in that broad spectrum antibacterial use is a very common association with those who develop infections due to Candida . (cdc.gov)
Species2
Host2
Rare1
- Candida glabrata endophthalmitis following keratoplasty is rare and almost always associated with positive donor rim culture. (medscape.com)
Positive1
- 9. Candida-specific systemic cell-mediated immune reactivities in human immunodeficiency virus-positive persons with mucosal candidiasis. (nih.gov)