A unicellular budding fungus which is the principal pathogenic species causing CANDIDIASIS (moniliasis).
A genus of yeast-like mitosporic Saccharomycetales fungi characterized by producing yeast cells, mycelia, pseudomycelia, and blastophores. It is commonly part of the normal flora of the skin, mouth, intestinal tract, and vagina, but can cause a variety of infections, including CANDIDIASIS; ONYCHOMYCOSIS; vulvovaginal candidiasis (CANDIDIASIS, VULVOVAGINAL), and thrush (see CANDIDIASIS, ORAL). (From Dorland, 28th ed)
Infection with a fungus of the genus CANDIDA. It is usually a superficial infection of the moist areas of the body and is generally caused by CANDIDA ALBICANS. (Dorland, 27th ed)
Microscopic threadlike filaments in FUNGI that are filled with a layer of protoplasm. Collectively, the hyphae make up the MYCELIUM.
Substances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues.
A species of MITOSPORIC FUNGI commonly found on the body surface. It causes opportunistic infections especially in immunocompromised patients.
Proteins found in any species of fungus.
Triazole antifungal agent that is used to treat oropharyngeal CANDIDIASIS and cryptococcal MENINGITIS in AIDS.
Infection of the mucous membranes of the mouth by a fungus of the genus CANDIDA. (Dorland, 27th ed)
The ability of fungi to resist or to become tolerant to chemotherapeutic agents, antifungal agents, or antibiotics. This resistance may be acquired through gene mutation.
A species of MITOSPORIC FUNGI that is a major cause of SEPTICEMIA and disseminated CANDIDIASIS, especially in patients with LYMPHOMA; LEUKEMIA; and DIABETES MELLITUS. It is also found as part of the normal human mucocutaneous flora.
Infection of the VULVA and VAGINA with a fungus of the genus CANDIDA.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in fungi.
Substances of fungal origin that have antigenic activity.
Five membered rings containing a NITROGEN atom.
Deoxyribonucleic acid that makes up the genetic material of fungi.
Procedures for identifying types and strains of fungi.
A group of small, histidine-rich, cationic peptides in human SALIVA which are antibacterial and antifungal.
Macrolide antifungal antibiotic produced by Streptomyces nodosus obtained from soil of the Orinoco river region of Venezuela.
Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses).
Polysaccharides consisting of mannose units.
The outermost layer of a cell in most PLANTS; BACTERIA; FUNGI; and ALGAE. The cell wall is usually a rigid structure that lies external to the CELL MEMBRANE, and provides a protective barrier against physical or chemical agents.
The functional hereditary units of FUNGI.
Encrustations, formed from microbes (bacteria, algae, fungi, plankton, or protozoa) embedding in extracellular polymers, that adhere to surfaces such as teeth (DENTAL DEPOSITS); PROSTHESES AND IMPLANTS; and catheters. Biofilms are prevented from forming by treating surfaces with DENTIFRICES; DISINFECTANTS; ANTI-INFECTIVE AGENTS; and antifouling agents.
The presence of fungi circulating in the blood. Opportunistic fungal sepsis is seen most often in immunosuppressed patients with severe neutropenia or in postoperative patients with intravenous catheters and usually follows prolonged antibiotic therapy.
Candidiasis of the skin manifested as eczema-like lesions of the interdigital spaces, perleche, or chronic paronychia. (Dorland, 27th ed)
Immunoglobulins produced in a response to FUNGAL ANTIGENS.
The study of the structure, growth, function, genetics, and reproduction of fungi, and MYCOSES.
Cyclic hexapeptides of proline-ornithine-threonine-proline-threonine-serine. The cyclization with a single non-peptide bond can lead them to be incorrectly called DEPSIPEPTIDES, but the echinocandins lack ester links. Antifungal activity is via inhibition of 1,3-beta-glucan synthase production of BETA-GLUCANS.
A colorless liquid extracted from oils of plants such as citronella, neroli, cyclamen, and tuberose. It is an intermediate step in the biological synthesis of cholesterol from mevalonic acid in vertebrates. It has a delicate odor and is used in perfumery. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
A steroid of interest both because its biosynthesis in FUNGI is a target of ANTIFUNGAL AGENTS, notably AZOLES, and because when it is present in SKIN of animals, ULTRAVIOLET RAYS break a bond to result in ERGOCALCIFEROL.
The ability of fungi to resist or to become tolerant to several structurally and functionally distinct drugs simultaneously. This resistance phenotype may be attributed to multiple gene mutations.
The oval-shaped oral cavity located at the apex of the digestive tract and consisting of two parts: the vestibule and the oral cavity proper.
Any liquid or solid preparation made specifically for the growth, storage, or transport of microorganisms or other types of cells. The variety of media that exist allow for the culturing of specific microorganisms and cell types, such as differential media, selective media, test media, and defined media. Solid media consist of liquid media that have been solidified with an agent such as AGAR or GELATIN.
A form of invasive candidiasis where species of CANDIDA are present in the blood.
The degree of pathogenicity within a group or species of microorganisms or viruses as indicated by case fatality rates and/or the ability of the organism to invade the tissues of the host. The pathogenic capacity of an organism is determined by its VIRULENCE FACTORS.
Inflammation of the mouth due to denture irritation.
Glucose polymers consisting of a backbone of beta(1->3)-linked beta-D-glucopyranosyl units with beta(1->6) linked side chains of various lengths. They are a major component of the CELL WALL of organisms and of soluble DIETARY FIBER.
A fluorinated cytosine analog that is used as an antifungal agent.
An imidazole antifungal agent that is used topically and by intravenous infusion.
Lining of the ORAL CAVITY, including mucosa on the GUMS; the PALATE; the LIP; the CHEEK; floor of the mouth; and other structures. The mucosa is generally a nonkeratinized stratified squamous EPITHELIUM covering muscle, bone, or glands but can show varying degree of keratinization at specific locations.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
An appliance used as an artificial or prosthetic replacement for missing teeth and adjacent tissues. It does not include CROWNS; DENTAL ABUTMENTS; nor TOOTH, ARTIFICIAL.
Broad spectrum antifungal agent used for long periods at high doses, especially in immunosuppressed patients.
An NADPH-dependent P450 enzyme that plays an essential role in the sterol biosynthetic pathway by catalyzing the demethylation of 14-methyl sterols such as lanosterol. The enzyme acts via the repeated hydroxylation of the 14-methyl group, resulting in its stepwise conversion into an alcohol, an aldehyde and then a carboxylate, which is removed as formic acid. Sterol 14-demethylase is an unusual cytochrome P450 enzyme in that it is found in a broad variety of organisms including ANIMALS; PLANTS; FUNGI; and protozoa.
Compounds consisting of a short peptide chain conjugated with an acyl chain.
A kingdom of eukaryotic, heterotrophic organisms that live parasitically as saprobes, including MUSHROOMS; YEASTS; smuts, molds, etc. They reproduce either sexually or asexually, and have life cycles that range from simple to complex. Filamentous fungi, commonly known as molds, refer to those that grow as multicellular colonies.
Enumeration by direct count of viable, isolated bacterial, archaeal, or fungal CELLS or SPORES capable of growth on solid CULTURE MEDIA. The method is used routinely by environmental microbiologists for quantifying organisms in AIR; FOOD; and WATER; by clinicians for measuring patients' microbial load; and in antimicrobial drug testing.
A species of the genus SACCHAROMYCES, family Saccharomycetaceae, order Saccharomycetales, known as "baker's" or "brewer's" yeast. The dried form is used as a dietary supplement.
A triazole antifungal agent that inhibits cytochrome P-450-dependent enzymes required for ERGOSTEROL synthesis.
A sub-subclass of endopeptidases that depend on an ASPARTIC ACID residue for their activity.
A property of the surface of an object that makes it stick to another surface.
The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.
Peptides whose amino and carboxy ends are linked together with a peptide bond forming a circular chain. Some of them are ANTI-INFECTIVE AGENTS. Some of them are biosynthesized non-ribosomally (PEPTIDE BIOSYNTHESIS, NON-RIBOSOMAL).
A genetic rearrangement through loss of segments of DNA or RNA, bringing sequences which are normally separated into close proximity. This deletion may be detected using cytogenetic techniques and can also be inferred from the phenotype, indicating a deletion at one specific locus.
Infection by a variety of fungi, usually through four possible mechanisms: superficial infection producing conjunctivitis, keratitis, or lacrimal obstruction; extension of infection from neighboring structures - skin, paranasal sinuses, nasopharynx; direct introduction during surgery or accidental penetrating trauma; or via the blood or lymphatic routes in patients with underlying mycoses.
Suspensions of attenuated or killed fungi administered for the prevention or treatment of infectious fungal disease.
The complete gene complement contained in a set of chromosomes in a fungus.
Ribonucleic acid in fungi having regulatory and catalytic roles as well as involvement in protein synthesis.
An imidazole derivative with a broad spectrum of antimycotic activity. It inhibits biosynthesis of the sterol ergostol, an important component of fungal CELL MEMBRANES. Its action leads to increased membrane permeability and apparent disruption of enzyme systems bound to the membrane.
A general term for single-celled rounded fungi that reproduce by budding. Brewers' and bakers' yeasts are SACCHAROMYCES CEREVISIAE; therapeutic dried yeast is YEAST, DRIED.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
The ability of microorganisms, especially bacteria, to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).
The engulfing and degradation of microorganisms; other cells that are dead, dying, or pathogenic; and foreign particles by phagocytic cells (PHAGOCYTES).
A linear polysaccharide of beta-1->4 linked units of ACETYLGLUCOSAMINE. It is the second most abundant biopolymer on earth, found especially in INSECTS and FUNGI. When deacetylated it is called CHITOSAN.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
An enzyme that converts UDP glucosamine into chitin and UDP. EC 2.4.1.16.
Inflammation of the vagina characterized by pain and a purulent discharge.
The genital canal in the female, extending from the UTERUS to the VULVA. (Stedman, 25th ed)
A subclass of peptide hydrolases that depend on an ASPARTIC ACID residue for their activity.
Macrolide antifungal antibiotic complex produced by Streptomyces noursei, S. aureus, and other Streptomyces species. The biologically active components of the complex are nystatin A1, A2, and A3.
Polysaccharides composed of repeating glucose units. They can consist of branched or unbranched chains in any linkages.
Genes that cause the epigenotype (i.e., the interrelated developmental pathways through which the adult organism is realized) to switch to an alternate cell lineage-related pathway. Switch complexes control the expression of normal functional development as well as oncogenic transformation.
A mitosporic Tremellales fungal genus whose species usually have a capsule and do not form pseudomycellium. Teleomorphs include Filobasidiella and Fidobasidium.
A complex sulfated polymer of galactose units, extracted from Gelidium cartilagineum, Gracilaria confervoides, and related red algae. It is used as a gel in the preparation of solid culture media for microorganisms, as a bulk laxative, in making emulsions, and as a supporting medium for immunodiffusion and immunoelectrophoresis.
A species of imperfect fungi from which the antibiotic fumigatin is obtained. Its spores may cause respiratory infection in birds and mammals.
Structures within the nucleus of fungal cells consisting of or containing DNA, which carry genetic information essential to the cell.
An important nosocomial fungal infection with species of the genus CANDIDA, most frequently CANDIDA ALBICANS. Invasive candidiasis occurs when candidiasis goes beyond a superficial infection and manifests as CANDIDEMIA, deep tissue infection, or disseminated disease with deep organ involvement.
Ability of a microbe to survive under given conditions. This can also be related to a colony's ability to replicate.
Proteins and peptides found in SALIVA and the SALIVARY GLANDS. Some salivary proteins such as ALPHA-AMYLASES are enzymes, but their composition varies in different individuals.
Inflammation of the inner lining of the heart (ENDOCARDIUM), the continuous membrane lining the four chambers and HEART VALVES. It is often caused by microorganisms including bacteria, viruses, fungi, and rickettsiae. Left untreated, endocarditis can damage heart valves and become life-threatening.
Reproductive bodies produced by fungi.
Fungal genes that mostly encode TRANSCRIPTION FACTORS. In some FUNGI they also encode PHEROMONES and PHEROMONE RECEPTORS. The transcription factors control expression of specific proteins that give a cell its mating identity. Opposite mating type identities are required for mating.
An exocellulase with specificity for 1,3-beta-D-glucasidic linkages. It catalyzes hydrolysis of beta-D-glucose units from the non-reducing ends of 1,3-beta-D-glucans, releasing GLUCOSE.
Proteins obtained from the species SACCHAROMYCES CEREVISIAE. The function of specific proteins from this organism are the subject of intense scientific interest and have been used to derive basic understanding of the functioning similar proteins in higher eukaryotes.
The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.
A species of the fungus CRYPTOCOCCUS. Its teleomorph is Filobasidiella neoformans.
Pathological processes involving the PHARYNX.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
The development of anatomical structures to create the form of a single- or multi-cell organism. Morphogenesis provides form changes of a part, parts, or the whole organism.
Adherence of cells to surfaces or to other cells.
A clinical syndrome characterized by development, usually in infancy or childhood, of a chronic, often widespread candidiasis of skin, nails, and mucous membranes. It may be secondary to one of the immunodeficiency syndromes, inherited as an autosomal recessive trait, or associated with defects in cell-mediated immunity, endocrine disorders, dental stomatitis, or malignancy.
Techniques used in microbiology.
Microscopy in which the object is examined directly by an electron beam scanning the specimen point-by-point. The image is constructed by detecting the products of specimen interactions that are projected above the plane of the sample, such as backscattered electrons. Although SCANNING TRANSMISSION ELECTRON MICROSCOPY also scans the specimen point by point with the electron beam, the image is constructed by detecting the electrons, or their interaction products that are transmitted through the sample plane, so that is a form of TRANSMISSION ELECTRON MICROSCOPY.
Cells, usually bacteria or yeast, which have partially lost their cell wall, lost their characteristic shape and become round.
Colorless, endogenous or exogenous pigment precursors that may be transformed by biological mechanisms into colored compounds; used in biochemical assays and in diagnosis as indicators, especially in the form of enzyme substrates. Synonym: chromogens (not to be confused with pigment-synthesizing bacteria also called chromogens).
The middle portion of the pharynx that lies posterior to the mouth, inferior to the SOFT PALATE, and superior to the base of the tongue and EPIGLOTTIS. It has a digestive function as food passes from the mouth into the oropharynx before entering ESOPHAGUS.
Opportunistic infections found in patients who test positive for human immunodeficiency virus (HIV). The most common include PNEUMOCYSTIS PNEUMONIA, Kaposi's sarcoma, cryptosporidiosis, herpes simplex, toxoplasmosis, cryptococcosis, and infections with Mycobacterium avium complex, Microsporidium, and Cytomegalovirus.
A test used to determine whether or not complementation (compensation in the form of dominance) will occur in a cell with a given mutant phenotype when another mutant genome, encoding the same mutant phenotype, is introduced into that cell.
The degree of similarity between sequences of amino acids. This information is useful for the analyzing genetic relatedness of proteins and species.
Substances that prevent infectious agents or organisms from spreading or kill infectious agents in order to prevent the spread of infection.
Polymerized forms of styrene used as a biocompatible material, especially in dentistry. They are thermoplastic and are used as insulators, for injection molding and casting, as sheets, plates, rods, rigid forms and beads.
The part of the face that is below the eye and to the side of the nose and mouth.
Membrane proteins whose primary function is to facilitate the transport of molecules across a biological membrane. Included in this broad category are proteins involved in active transport (BIOLOGICAL TRANSPORT, ACTIVE), facilitated transport and ION CHANNELS.
A disinfectant and topical anti-infective agent used also as mouthwash to prevent oral plaque.
Enzymes that catalyze the transfer of mannose from a nucleoside diphosphate mannose to an acceptor molecule which is frequently another carbohydrate. The group includes EC 2.4.1.32, EC 2.4.1.48, EC 2.4.1.54, and EC 2.4.1.57.
Granular leukocytes having a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes.
The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.
Steroids with a hydroxyl group at C-3 and most of the skeleton of cholestane. Additional carbon atoms may be present in the side chain. (IUPAC Steroid Nomenclature, 1987)
The property of objects that determines the direction of heat flow when they are placed in direct thermal contact. The temperature is the energy of microscopic motions (vibrational and translational) of the particles of atoms.
Compounds with 1,2-diphenylethane. They are structurally like reduced STILBENES.
Elements of limited time intervals, contributing to particular results or situations.
The clear, viscous fluid secreted by the SALIVARY GLANDS and mucous glands of the mouth. It contains MUCINS, water, organic salts, and ptylin.
The body fluid that circulates in the vascular system (BLOOD VESSELS). Whole blood includes PLASMA and BLOOD CELLS.
The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH = log 1/2[1/(H+)], where (H+) is the hydrogen ion concentration in gram equivalents per liter of solution. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
Enzymes that catalyze the transfer of glucose from a nucleoside diphosphate glucose to an acceptor molecule which is frequently another carbohydrate. EC 2.4.1.-.
An endocellulase with specificity for the hydrolysis of 1,3-beta-D-glucosidic linkages in 1,3-beta-D-glucans including laminarin, paramylon, and pachyman.
Substances that reduce the growth or reproduction of BACTERIA.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
An imidazole derivative that is commonly used as a topical antifungal agent.
A mitosporic fungal genus and an anamorphic form of Arthroderma. Various species attack the skin, nails, and hair.
A systemic agricultural fungicide used for control of certain fungal diseases of stone fruit.
Glycoproteins found on the membrane or surface of cells.
Infections with fungi of the genus ASPERGILLUS.
A method (first developed by E.M. Southern) for detection of DNA that has been electrophoretically separated and immobilized by blotting on nitrocellulose or other type of paper or nylon membrane followed by hybridization with labeled NUCLEIC ACID PROBES.
A ketose sugar that is commonly used in the commercial synthesis of ASCORBIC ACID.
Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.
A mitosporic fungal genus causing opportunistic infections, endocarditis, fungemia, a hypersensitivity pneumonitis (see TRICHOSPORONOSIS) and white PIEDRA.
Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.
The interactions between a host and a pathogen, usually resulting in disease.
One of the three domains of life (the others being Eukarya and ARCHAEA), also called Eubacteria. They are unicellular prokaryotic microorganisms which generally possess rigid cell walls, multiply by cell division, and exhibit three principal forms: round or coccal, rodlike or bacillary, and spiral or spirochetal. Bacteria can be classified by their response to OXYGEN: aerobic, anaerobic, or facultatively anaerobic; by the mode by which they obtain their energy: chemotrophy (via chemical reaction) or PHOTOTROPHY (via light reaction); for chemotrophs by their source of chemical energy: CHEMOLITHOTROPHY (from inorganic compounds) or chemoorganotrophy (from organic compounds); and by their source for CARBON; NITROGEN; etc.; HETEROTROPHY (from organic sources) or AUTOTROPHY (from CARBON DIOXIDE). They can also be classified by whether or not they stain (based on the structure of their CELL WALLS) with CRYSTAL VIOLET dye: gram-negative or gram-positive.
A large and heterogenous group of fungi whose common characteristic is the absence of a sexual state. Many of the pathogenic fungi in humans belong to this group.
A hexose or fermentable monosaccharide and isomer of glucose from manna, the ash Fraxinus ornus and related plants. (From Grant & Hackh's Chemical Dictionary, 5th ed & Random House Unabridged Dictionary, 2d ed)
A technique for identifying individuals of a species that is based on the uniqueness of their DNA sequence. Uniqueness is determined by identifying which combination of allelic variations occur in the individual at a statistically relevant number of different loci. In forensic studies, RESTRICTION FRAGMENT LENGTH POLYMORPHISM of multiple, highly polymorphic VNTR LOCI or MICROSATELLITE REPEAT loci are analyzed. The number of loci used for the profile depends on the ALLELE FREQUENCY in the population.
Quaternary salts derived from tetrazoles. They are used in tests to distinguish between reducing sugars and simple aldehydes, for detection of dehydrogenase in tissues, cells, and bacteria, for determination of corticosteroids, and in color photography. (From Mall's Dictionary of Chemistry, 5th ed, p455)
Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is evaporated away, and adjusting the residue to a prescribed standard.
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)
A multistage process that includes cloning, physical mapping, subcloning, determination of the DNA SEQUENCE, and information analysis.
The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.
A genus of mitosporic fungi containing about 100 species and eleven different teleomorphs in the family Trichocomaceae.
A class of animal lectins that bind to carbohydrate in a calcium-dependent manner. They share a common carbohydrate-binding domain that is structurally distinct from other classes of lectins.
Polymers of silicone that are formed by crosslinking and treatment with amorphous silica to increase strength. They have properties similar to vulcanized natural rubber, in that they stretch under tension, retract rapidly, and fully recover to their original dimensions upon release. They are used in the encapsulation of surgical membranes and implants.
A family of 6-membered heterocyclic compounds occurring in nature in a wide variety of forms. They include several nucleic acid constituents (CYTOSINE; THYMINE; and URACIL) and form the basic structure of the barbiturates.
Substances used to clean dentures; they are usually alkaline peroxides or hypochlorites, may contain enzymes and release oxygen. Use also for sonic action cleaners.
The N-acetyl derivative of glucosamine.

Non-serum-dependent chemotactic factors produced by Candida albicans stimulate chemotaxis by binding to the formyl peptide receptor on neutrophils and to an unknown receptor on macrophages. (1/5658)

Serum-free culture filtrates of six Candida species and Saccharomyces cerevisiae were found to contain chemoattractants for human polymorphonuclear leukocytes (PMNs) and a mouse macrophage-like cell line, J774. The chemotactic factors differed for the PMN and J774 cells, however, in terms of heat stability, kinetics of liberation by the yeast cells, and divalent cation requirements for production. The chemoattractant in Candida albicans culture filtrates appeared to act through the formyl peptide receptor (FPR) of PMNs, since it was found to induce chemotaxis of Chinese hamster ovary (CHO) cells that were expressing the human FPR but did not induce chemotaxis of wild-type CHO cells. The C. albicans culture filtrates also induced migration of PMNs across confluent monolayers of a human gastrointestinal epithelial cell line, T84; migration occurred in the basolateral-to-apical direction but not the reverse direction, unless the epithelial tight junctions were disrupted. J774 cells did not migrate toward the formylated peptide (fMet-Leu-Phe; fMLF), and chemotaxis toward the C. albicans culture filtrate was not inhibited by an FPR antagonist (t-butoxycarbonyl-Met-Leu-Phe), suggesting that a different receptor mediated J774 cell chemotaxis. In conclusion, we have identified a receptor by which a non-serum-dependent chemotactic factor (NSCF) produced by C. albicans induced chemotaxis of PMNs. Additionally, we have shown that NSCF was active across epithelial monolayers. These findings suggest that NSCFs produced by C. albicans and other yeast species may influence host-pathogen interactions at the gastrointestinal tract mucosal surface by inducing phagocytic-cell infiltration.  (+info)

Role of the extracellular signal-regulated protein kinase cascade in human neutrophil killing of Staphylococcus aureus and Candida albicans and in migration. (2/5658)

Killing of Staphylococcus aureus and Candida albicans by neutrophils involves adherence of the microorganisms, phagocytosis, and a collaborative action of oxygen reactive species and components of the granules. While a number of intracellular signalling pathways have been proposed to regulate neutrophil responses, the extent to which each pathway contributes to the killing of S. aureus and C. albicans has not been clearly defined. We have therefore examined the effect of blocking one such pathway, the extracellular signal-regulated protein kinase (ERK) cascade, using the specific inhibitor of the mitogen-activated protein kinase/ERK kinase, PD98059, on the ability of human neutrophils to kill S. aureus and C. albicans. Our data demonstrate the presence of ERK2 and a 43-kDa form of ERK but not ERK1 in human neutrophils. Upon stimulation with formyl methionyl leucyl phenylalanine (fMLP), the activities of both ERK2 and the 43-kDa form were stimulated. Despite abrogating the activity of both ERK forms, PD98059 only slightly reduced the ability of neutrophils to kill S. aureus or C. albicans. This is consistent with our finding that PD98059 had no effect on neutrophil adherence or degranulation, although pretreatment of neutrophils with PD98059 inhibited fMLP-stimulated superoxide production by 50%, suggesting that a change in superoxide production per se is not strictly correlated with microbicidal activity. However, fMLP-stimulated chemokinesis was markedly inhibited, while random migration and fMLP-stimulated chemotaxis were partially inhibited, by PD98059. These data demonstrate, for the first time, that the ERK cascade plays only a minor role in the microbicidal activity of neutrophils and that the ERK cascade is involved primarily in regulating neutrophil migration in response to fMLP.  (+info)

BE-31405, a new antifungal antibiotic produced by Penicillium minioluteum. I. Description of producing organism, fermentation, isolation, physico-chemical and biological properties. (3/5658)

A new antifungal antibiotic, BE-31405, was isolated from the culture broth of a fungal strain, Penicillium minioluteum F31405. BE-31405 was isolated by adsorption on high porous polymer resin (Diaion HP-20), followed by solvent extraction, precipitation and crystallization. BE-31405 showed potent growth inhibitory activity against pathogenic fungal strains such as Candida albicans, Candida glabrata and Cryptococcus neoformans, but did not show cytotoxic activity against mammalian cells such as P388 mouse leukemia. The mechanism studies indicated that BE-31405 inhibited the protein synthesis of C. albicans but not of mammalian cells.  (+info)

Synergic effects of tactolimus and azole antifungal agents against azole-resistant Candida albican strains. (4/5658)

We investigated the effects of combining tacrolimus and azole antifungal agents in azole-resistant strains of Candida albicans by comparing the accumulation of [3H]itraconazole. The CDR1-expressing resistant strain C26 accumulated less itraconazole than the CaMDR-expressing resistant strain C40 or the azole-sensitive strain B2630. A CDR1-expressing Saccharomyces cerevisiae mutant, DSY415, showed a marked reduction in the accumulation of both fluconazole and itraconazole. A CaMDR-expressing S. cerevisiae mutant, DSY416, also showed lower accumulation of fluconazole, but not of itraconazole. The addition of sodium azide, an electron-transport chain inhibitor, increased the intracellular accumulation of itraconazole only in the C26 strain, and not in the C40 or B2630 strains. Addition of tacrolimus, an inhibitor of multidrug resistance proteins, resulted in the highest increase in itraconazole accumulation in the C26 strain. The combination of itraconazole and tacrolimus was synergic in azole-resistant C. albicans strains. In the C26 strain, the MIC of itraconazole decreased from >8 to 0.5 mg/L when combined with tacrolimus. Our results showed that two multidrug resistance phenotypes (encoded by the CDR1 and CaMDR genes) in C. albicans have different substrate specificity for azole antifungal agents and that a combination of tacrolimus and azole antifungal agents is effective against azole-resistant strains of C. albicans.  (+info)

In-vivo therapeutic efficacy in experimental murine mycoses of a new formulation of deoxycholate-amphotericin B obtained by mild heating. (5/5658)

Heat-induced 'superaggregation' of deoxycholate-amphotericin B (AmB-DOC, Fungizone) was shown previously to reduce the in-vitro toxicity of this antifungal agent. We compared AmB-DOC with the formulation obtained by heating the commercial form (Fungizone, Bristol Myers Squibb, Paris, France) for 20 min at 70 degrees C, in the treatment of murine infections. An improvement of antifungal activity was obtained with heated AmB-DOC formulations due to a lower toxicity which allowed the administration of higher drug doses than those achievable with the commercial preparation. Single intravenous injections of heated AmB-DOC solutions were demonstrated to be two-fold less toxic than unheated ones to healthy mice. For mice infected with Candida albicans, the maximum tolerated dose was higher with heated than with unheated AmB-DOC solutions. In the model of murine candidiasis, following a single dose of heated AmB-DOC 0.5 mg/kg, 85% of mice survived for 3 weeks, whereas at this dose the immediate toxicity of the standard formulation in infected mice restricted the therapeutic efficacy to 25% survival. Both formulations were equally effective in increasing the survival time for murine cryptococcal pneumonia and meningoencephalitis. Injection of heated AmB-DOC solutions at a dose two-fold higher than the maximal tolerated dose observed with the unheated preparation (1.2 mg/kg) increased the survival time by a factor of 1.4 in cryptococcal meningoencephalitis. These results indicate that mild heat treatment of AmB-DOC solutions could provide a simple and economical method to improve the therapeutic index of this antifungal agent by reducing its toxicity on mammalian cells.  (+info)

Adhesive and mammalian transglutaminase substrate properties of Candida albicans Hwp1. (6/5658)

The pathogenesis of candidiasis involves invasion of host tissues by filamentous forms of the opportunistic yeast Candida albicans. Morphology-specific gene products may confer proinvasive properties. A hypha-specific surface protein, Hwp1, with similarities to mammalian small proline-rich proteins was shown to serve as a substrate for mammalian transglutaminases. Candida albicans strains lacking Hwp1 were unable to form stable attachments to human buccal epithelial cells and had a reduced capacity to cause systemic candidiasis in mice. This represents a paradigm for microbial adhesion that implicates essential host enzymes.  (+info)

The cellular target of histatin 5 on Candida albicans is the energized mitochondrion. (7/5658)

Histatin 5 is a human basic salivary peptide with strong fungicidal properties in vitro. To elucidate the mechanism of action, the effect of histatin 5 on the viability of Candida albicans cells was studied in relation to its membrane perturbing properties. It was found that both the killing activity and the membrane perturbing activity, studied by the influx of a DNA-specific marker propidium iodide, were inhibited by high salt conditions and by metabolic inhibitors, like sodium azide. In addition, exposure to histatin 5 resulted in a loss of the mitochondrial transmembrane potential in situ, measured by the release of the potential-dependent distributional probe rhodamine 123. Localization studies using tetramethylrhodamine isothiocyanate-labeled histatin 5 or fluorescein isothiocyanate-labeled histatin 5 showed a granular intracellular distribution of the peptide, which co-localized with mitotracker orange, a permeant mitochondria-specific probe. Like the biological effects, uptake of labeled histatin 5 was inhibited by mitochondrial inhibitors and high salt conditions. Our data indicate that histatin 5 is internalized, and targets to the energized mitochondrion.  (+info)

Rapid hypothesis testing with Candida albicans through gene disruption with short homology regions. (8/5658)

Disruption of newly identified genes in the pathogen Candida albicans is a vital step in determination of gene function. Several gene disruption methods described previously employ long regions of homology flanking a selectable marker. Here, we describe disruption of C. albicans genes with PCR products that have 50 to 60 bp of homology to a genomic sequence on each end of a selectable marker. We used the method to disrupt two known genes, ARG5 and ADE2, and two sequences newly identified through the Candida genome project, HRM101 and ENX3. HRM101 and ENX3 are homologous to genes in the conserved RIM101 (previously called RIM1) and PacC pathways of Saccharomyces cerevisiae and Aspergillus nidulans. We show that three independent hrm101/hrm101 mutants and two independent enx3/enx3 mutants are defective in filamentation on Spider medium. These observations argue that HRM101 and ENX3 sequences are indeed portions of genes and that the respective gene products have related functions.  (+info)

Types of candidiasis:

1. Vulvovaginal candidiasis (VVC): a common infection that affects the vagina and vulva; symptoms include itching, burning, and abnormal discharge.
2. Oral thrush (OT): an infection that affects the mouth, often seen in infants and people with weakened immune systems; symptoms include white patches on the tongue and inside the cheeks.
3. Invasive candidiasis (IC): a severe infection that can spread throughout the body, often seen in people with weakened immune systems, such as those with HIV/AIDS or undergoing chemotherapy; symptoms include fever, chills, and difficulty breathing.
4. Candidal balanitis: an infection of the foreskin and glans of the penis; symptoms include redness, swelling, and pain.
5. Diaper rash: a common skin infection that affects infants who wear diapers; symptoms include redness, swelling, and irritability.

Causes and risk factors:

1. Overgrowth of Candida fungus due to an imbalance of the normal flora.
2. Use of antibiotics or steroids that can disrupt the balance of the body's natural flora.
3. Weakened immune system, such as in people with HIV/AIDS or undergoing chemotherapy.
4. Poor hygiene and sanitation.
5. Diabetes mellitus.
6. Pregnancy.
7. Obesity.

Diagnosis:

1. Physical examination and medical history.
2. Microscopic examination of a scraping or biopsy specimen.
3. Cultures of skin, blood, or other body fluids.
4. Polymerase chain reaction (PCR) or other molecular diagnostic techniques to detect the presence of the fungus.

Treatment:

1. Topical antifungal medications, such as clotrimazole, miconazole, or terbinafine, applied directly to the affected area.
2. Oral antifungal medications, such as fluconazole or itraconazole, for more severe infections or those that do not respond to topical treatment.
3. Antibiotics if there is a secondary bacterial infection.
4. Supportive care, such as pain management and wound care.
5. Proper hygiene and sanitation practices.
6. In severe cases, hospitalization may be necessary for intravenous antifungal medications and close monitoring.

Prevention:

1. Practice good hygiene and sanitation.
2. Avoid sharing personal items, such as towels or clothing.
3. Wash hands before touching the affected area.
4. Keep the affected area clean and dry.
5. Use of antifungal powders or sprays on the affected area.
6. Avoid using harsh soaps or cleansers that can irritate the skin.
7. Wear shoes in public areas to prevent exposure to fungal spores.
8. Avoid sharing bathing or showering facilities with others.
9. Dry thoroughly after bathing or swimming.
10. Use of antifungal medications as a prophylactic measure in high-risk individuals, such as those with weakened immune systems.

It's important to note that the best treatment and prevention strategies will depend on the specific type of fungus causing the infection, as well as the severity and location of the infection. It is essential to consult a healthcare professional for proper diagnosis and treatment.

The infection is usually caused by an overgrowth of Candida, which is a normal flora in the mouth, but can become pathogenic under certain conditions. Risk factors for developing OC include taking antibiotics, wearing dentures, pregnancy, diabetes, and HIV/AIDS.

OC can be diagnosed by examining the mouth and throat with a mirror and torch, as well as through laboratory tests such as cultures or PCR. Treatment typically involves antifungal medication, good oral hygiene practices, and addressing any underlying conditions. In severe cases, hospitalization may be necessary.

Preventative measures include practicing good oral hygiene, avoiding smoking, and managing any underlying medical conditions. In addition, early diagnosis and treatment can help prevent the infection from spreading to other parts of the body, such as the bloodstream or heart.

Causes:
The most common cause of candidiasis is an imbalance in the natural bacteria and yeast that live in and around the vagina. This imbalance can be caused by a variety of factors, including:

* Taking antibiotics, which can kill off the "good" bacteria that keep candida in check
* Pregnancy and menopause, when hormonal changes can lead to an overgrowth of yeast
* Diabetes, which can cause excess sugar in the body that feeds the growth of yeast
* Weakened immune system
* Poor hygiene or poor fitting clothing and underwear that can trap moisture and create a warm environment for yeast to grow.

Symptoms:
The symptoms of candidiasis can vary from person to person, but common signs include:

* Itching, burning, and redness of the vulva and vagina
* A thick, white discharge that looks like cottage cheese and has no odor or a mild, sweet smell
* Pain or discomfort during sex
* Difficulty getting pregnant (infertility) if the infection is severe or recurrent.

Diagnosis:
A healthcare provider can diagnose candidiasis by performing a physical examination and taking a sample of vaginal discharge for testing. The provider may also take a culture of the yeast to determine which type of candida is causing the infection.

Treatment:
Candidiasis can be treated with antifungal medications, such as clotrimazole or terconazole. These medications are available over-the-counter or by prescription and come in creams, tablets, or suppositories. To help clear the infection, treatment may also include:

* Avoiding irritants such as douches, powders, or scented soaps
* Wearing loose-fitting clothing and cotton underwear
* Keeping the genital area clean and dry
* Avoiding sex during treatment

Complications:
If left untreated, candidiasis can lead to complications such as:

* Recurrent infections
* Inflammation of the vulva (vulvodynia)
* Inflammation of the vagina (vaginitis)
* Pain during sex
* Difficulty getting pregnant (infertility)

Prevention:
To prevent candidiasis, women can take the following steps:

* Practice good hygiene by washing the genital area gently with soap and water
* Avoid using douches, powders, or scented soaps
* Wear loose-fitting clothing and cotton underwear
* Change out of wet or sweaty clothes as soon as possible
* Avoid sex during treatment for candidiasis.

Prognosis:
With proper treatment, the prognosis for candidiasis is good. The infection usually clears up within a week or two with antifungal medication. However, recurrent infections can be more difficult to treat and may require longer courses of therapy. In some cases, candidiasis can lead to complications such as inflammation of the vulva or vagina, which can be more challenging to treat.

It is important for women to seek medical attention if they experience any symptoms of candidiasis, as early diagnosis and treatment can help prevent complications and improve outcomes.

Symptoms of fungemia may include fever, chills, night sweats, fatigue, and weight loss. Diagnosis is typically made by drawing blood cultures and performing microbiological tests to identify the presence of fungal organisms in the blood. Treatment typically involves administration of antifungal medications, which can be given intravenously or orally. In severe cases, hospitalization may be necessary to monitor and treat the condition.

In some cases, fungemia can lead to complications such as sepsis, organ failure, and death. Prompt diagnosis and treatment are essential to prevent these outcomes.

The symptoms of candidiasis, cutaneous may include:

* Redness and swelling on the affected area
* Itching and burning sensation
* Thickening and discoloration of the skin
* Cracks or fissures in the skin

Candidiasis, cutaneous can be diagnosed through a physical examination and may require additional tests such as a skin scraping or biopsy to confirm the diagnosis. Treatment typically involves antifungal medications and good wound care. In severe cases, hospitalization may be required.

Prevention is key in avoiding candidiasis, cutaneous. Good hygiene practices such as frequent handwashing, keeping the skin clean and dry, and avoiding sharing personal items can help reduce the risk of infection. Additionally, managing underlying conditions such as diabetes and taking antibiotics only when necessary can also help prevent candidiasis, cutaneous.

Candidemia can cause a range of symptoms, including fever, chills, rapid heart rate, and confusion. In severe cases, it can lead to organ failure and death. Treatment typically involves the use of antifungal medications, and in some cases, hospitalization is necessary to manage the infection and monitor the patient's condition.

Preventative measures to reduce the risk of developing candidemia include proper handwashing and hygiene, avoiding close contact with people who are sick, and ensuring that medical equipment and surfaces are properly cleaned and disinfected. Early detection and treatment can significantly improve outcomes for patients with candidemia.

Also known as:

* Denture stomatitis
* Mucositis
* Gingivostomatitis

Causes and risk factors:

* Ill-fitting dentures
* Poor dental hygiene
* Smoking
* Diabetes
* AIDS
* Old age

Symptoms:

* Pain or discomfort in the mouth
* Ulcers on the gums and inner cheeks
* Difficulty eating or speaking
* Redness and swelling of the gums

Diagnosis:

* Physical examination of the mouth and dentures
* Medical history review
* Blood tests to rule out underlying conditions

Treatment:

* Fitting a new denture or relining the existing one to improve fit
* Improving dental hygiene habits
* Antibiotics for bacterial infections
* Pain relief medication

Prevention:

* Regular dental check-ups and cleaning of dentures
* Proper fit and maintenance of dentures
* Good oral hygiene practices

Note that this is a general overview of the topic, and it's always best to consult with a medical professional for specific advice.

The most common types of mycoses include:

1. Ringworm: This is a common fungal infection that causes a ring-shaped rash on the skin. It can affect any part of the body, including the arms, legs, torso, and face.
2. Athlete's foot: This is a common fungal infection that affects the feet, causing itching, redness, and cracking of the skin.
3. Jock itch: This is a fungal infection that affects the groin area and inner thighs, causing itching, redness, and cracking of the skin.
4. Candidiasis: This is a fungal infection caused by Candida, a type of yeast. It can affect various parts of the body, including the mouth, throat, and vagina.
5. Aspergillosis: This is a serious fungal infection that can affect various parts of the body, including the lungs, sinuses, and brain.

Symptoms of mycoses can vary depending on the type of infection and the severity of the infection. Common symptoms include itching, redness, swelling, and cracking of the skin. Treatment for mycoses usually involves antifungal medications, which can be applied topically or taken orally. In severe cases, hospitalization may be necessary to monitor and treat the infection.

Preventive measures for mycoses include practicing good hygiene, avoiding sharing personal items such as towels and clothing, and using antifungal medications as prescribed by a healthcare professional. Early diagnosis and treatment of mycoses can help prevent complications and reduce the risk of transmission to others.

There are several types of fungal eye infections, including:

1. Aspergillosis: This is a common type of fungal infection that affects the eye. It is caused by the fungus Aspergillus and can occur in people with weakened immune systems or pre-existing eye conditions.
2. Candidemia: This is another common type of fungal infection that affects the eye. It is caused by the fungus Candida and can occur in people with weakened immune systems or pre-existing eye conditions.
3. Cryptococcosis: This is a rare type of fungal infection that affects the eye. It is caused by the fungus Cryptococcus and can occur in people with weakened immune systems, such as those with HIV/AIDS.
4. Histoplasmosis: This is a rare type of fungal infection that affects the eye. It is caused by the fungus Histoplasma and can occur in people who have been exposed to the fungus in soil or bird droppings.
5. Blastomycosis: This is a rare type of fungal infection that affects the eye. It is caused by the fungus Blastomyces and can occur in people who have been exposed to the fungus in soil or water.

Fungal eye infections can cause a range of symptoms, including redness, discharge, pain, and vision loss. Treatment typically involves antifungal medication and may also include surgery to remove any infected tissue. In severe cases, fungal eye infections can lead to blindness if left untreated.

Prevention measures for fungal eye infections include good hygiene practices, such as washing hands regularly and avoiding close contact with people who have the infection. People with weakened immune systems should also avoid exposure to fungi by avoiding outdoor activities during peak fungal growth seasons and wearing protective clothing when working or playing in areas where fungi are likely to be present.

Overall, fungal eye infections are uncommon but can be serious conditions that require prompt medical attention. If you suspect you may have a fungal eye infection, it is important to seek medical care as soon as possible to receive proper diagnosis and treatment.

There are several types of vaginitis, including:

1. Bacterial vaginosis (BV): This is the most common type of vaginitis and is caused by an overgrowth of harmful bacteria in the vagina. It can be treated with antibiotics.
2. Yeast infection: This type of vaginitis is caused by a fungal infection, usually caused by the organism Candida. It can be treated with antifungal medications.
3. Trichomoniasis: This is a sexually transmitted infection (STI) caused by the parasite Trichomonas vaginalis. It can be treated with antiparasitic medication.
4. Atrophic vaginitis: This type of vaginitis is caused by hormonal changes and is more common in menopausal women. It can be treated with hormone replacement therapy or other medications.
5. Vaginal lichen sclerosus: This is a chronic condition that causes thickening and inflammation of the vaginal tissues, leading to itching and pain during sex.

Symptoms of vaginitis can include:

* Itching, burning, or soreness in the vagina
* Thick, white discharge that may have a strong odor
* Pain or discomfort during sex
* Redness and swelling of the vulva (the external female genital area)

If you suspect you have vaginitis, it is important to see a healthcare provider for proper diagnosis and treatment. They may perform a physical examination, take a sample of vaginal secretions for testing, and/or perform other diagnostic tests such as a pelvic exam or ultrasound. Treatment will depend on the underlying cause of the condition, but may include antibiotics, antifungal medication, or other medications to relieve symptoms.

Preventing vaginitis involves practicing good hygiene and taking steps to maintain a healthy balance of bacteria in the vagina. This can include:

* Wiping from front to back after using the bathroom to prevent bacteria from the anus entering the vagina
* Avoiding douching, which can disrupt the natural balance of bacteria in the vagina
* Avoiding tight-fitting clothing and underwear that can trap moisture and create an ideal environment for bacteria to grow
* Using mild, fragrance-free soap and water to clean the genital area
* Avoiding using scented products or powders in the genital area
* Getting regular gynecological exams to ensure any underlying conditions are identified and treated promptly.

It is also important to note that vaginitis can be a symptom of other underlying conditions, so if you experience recurring or persistent symptoms, it is important to see a healthcare provider for proper diagnosis and treatment.

Candidiasis, invasive is caused by the overgrowth of Candida in the body, which can occur for a variety of reasons, such as:

* Weakened immune system due to HIV/AIDS, cancer, or medications that suppress the immune system.
* Invasive medical devices, such as central lines or implanted pacemakers.
* Previous history of invasive candidiasis.
* Pregnancy.
* Intravenous drug use.

The symptoms of candidiasis, invasive can vary depending on the organs affected, but may include:

* Fever.
* Chills.
* Shortness of breath.
* Pain in the abdomen or chest.
* Confusion or disorientation.
* Skin rash or lesions.

Diagnosis of candidiasis, invasive is based on a combination of physical examination, medical history, and laboratory tests, such as blood cultures and imaging studies. Treatment typically involves the use of antifungal medications, which may be given intravenously or orally, depending on the severity of the infection. In severe cases, hospitalization may be necessary to monitor and treat the infection.

Prevention of candidiasis, invasive includes:

* Proper hygiene and handwashing practices.
* Avoiding close contact with individuals who have invasive candidiasis.
* Avoiding sharing of personal items, such as toothbrushes or razors.
* Avoiding the use of invasive medical devices, if possible.
* Proper care and maintenance of medical devices.
* Monitoring for signs of infection in individuals with weakened immune systems.

In conclusion, candidiasis, invasive is a serious and potentially life-threatening fungal infection that can affect various organs and systems in the body. Early diagnosis and treatment are crucial to prevent complications and improve outcomes. Proper prevention and control measures can help reduce the risk of developing invasive candidiasis.

Symptoms of endocarditis may include fever, fatigue, joint pain, and swelling in the legs and feet. In some cases, the condition can lead to serious complications, such as heart valve damage, stroke, or death.

Treatment for endocarditis typically involves antibiotics to clear the infection. In severe cases, surgery may be necessary to repair or replace damaged heart tissue. Preventive measures include good dental hygiene, avoiding risky behaviors such as injecting drugs, and keeping wounds clean and covered.

Endocarditis is a serious condition that can have long-term consequences if left untreated. Early diagnosis and treatment are essential to prevent complications and ensure the best possible outcome for patients.

Some common types of pharyngeal diseases include:

1. Pharyngitis: This is an inflammation of the pharynx, often caused by viral or bacterial infections. Symptoms may include sore throat, fever, and difficulty swallowing.
2. Tonsillitis: This is an inflammation of the tonsils, which are small gland-like structures located on either side of the back of the throat. Symptoms may include sore throat, fever, and difficulty swallowing.
3. Adenoiditis: This is an inflammation of the adenoids, which are small gland-like structures located in the back of the nasopharynx. Symptoms may include sore throat, fever, and difficulty breathing through the nose.
4. Epiglottitis: This is an inflammation of the epiglottis, which is a flap-like structure that covers the entrance to the larynx (voice box). Symptoms may include fever, sore throat, and difficulty breathing.
5. Laryngitis: This is an inflammation of the larynx (voice box), often caused by viral or bacterial infections. Symptoms may include hoarseness, loss of voice, and difficulty speaking.
6. Sinusitis: This is an inflammation of the sinuses, which are air-filled cavities located within the skull. Symptoms may include facial pain, headache, and nasal congestion.
7. Otitis media: This is an infection of the middle ear, often caused by viral or bacterial infections. Symptoms may include ear pain, fever, and difficulty hearing.
8. Laryngosporangium: This is a type of fungal infection that affects the larynx (voice box) and is more common in hot and humid climates. Symptoms may include hoarseness, cough, and difficulty speaking.
9. Subglottic stenosis: This is a narrowing of the airway below the vocal cords, which can be caused by inflammation or scarring. Symptoms may include difficulty breathing, wheezing, and coughing.
10. Tracheomalacia: This is a softening of the walls of the trachea (windpipe), which can cause the airway to become narrow and obstructed. Symptoms may include difficulty breathing, wheezing, and coughing.

It's important to note that these are just some of the possible causes of a sore throat and difficulty breathing, and it's always best to consult with a healthcare professional for an accurate diagnosis and appropriate treatment.

Symptoms:

* White patches or lesions on the tongue, inside the cheeks, on the gums, and on the skin folds of the neck, armpits, groin, and under the breasts
* Redness and inflammation around the affected areas
* Itching, burning sensations, and pain in the affected areas
* Thickening and discoloration of the nails
* Bad breath or a "furry" tongue
* Skin cracks and fissures
* Nail brittleness and breaking

Causes:

* Overgrowth of Candida fungus, which is normally present in the body
* Poor oral hygiene
* Smoking
* Diabetes
* Obesity
* Hormonal changes during pregnancy or menopause
* Weakened immune system
* Prolonged use of antibiotics or steroids
* Cancer treatment

Diagnosis:

* Physical examination and observation of the symptoms
* Skin scraping or biopsy to confirm the presence of Candida fungus
* Blood tests to rule out other conditions

Treatment:

* Antifungal medications, such as clotrimazole, miconazole, and terbinafine, to kill the fungus
* Good oral hygiene practices, such as brushing and flossing regularly
* Avoiding smoking and sugar-rich diet
* Keeping the skin dry and clean
* Wearing loose-fitting clothing to reduce skin irritation
* Using a medicated mouthwash to treat oral thrush
* In severe cases, hospitalization may be necessary for intravenous antifungal medication

It is important to note that these are general guidelines and the best course of treatment will depend on the severity and location of the infection. A healthcare professional should always be consulted for proper diagnosis and treatment.

Examples of AROIs include:

1. Pneumocystis pneumonia (PCP): a type of pneumonia caused by the fungus Pneumocystis jirovecii.
2. Tuberculosis (TB): a bacterial infection that can affect the lungs, brain, or other organs.
3. Toxoplasmosis: an infection caused by the parasite Toxoplasma gondii that can affect the brain, eyes, and other organs.
4. Cryptococcosis: a fungal infection that can affect the lungs, brain, or skin.
5. Histoplasmosis: a fungal infection caused by Histoplasma capsulatum that can affect the lungs, skin, and other organs.
6. Aspergillosis: a fungal infection caused by Aspergillus species that can affect the lungs, sinuses, and other organs.
7. Candidiasis: a fungal infection caused by Candida species that can affect the mouth, throat, vagina, or skin.
8. Kaposi's sarcoma: a type of cancer that is caused by the human herpesvirus 8 (HHV-8) and can affect the skin and lymph nodes.
9. Wasting syndrome: a condition characterized by weight loss, fatigue, and diarrhea.
10. Opportunistic infections that can affect the gastrointestinal tract, such as cryptosporidiosis and isosporiasis.

AROIs are a major cause of morbidity and mortality in individuals with HIV/AIDS, and they can be prevented or treated with antimicrobial therapy, supportive care, and other interventions.

1) They share similarities with humans: Many animal species share similar biological and physiological characteristics with humans, making them useful for studying human diseases. For example, mice and rats are often used to study diseases such as diabetes, heart disease, and cancer because they have similar metabolic and cardiovascular systems to humans.

2) They can be genetically manipulated: Animal disease models can be genetically engineered to develop specific diseases or to model human genetic disorders. This allows researchers to study the progression of the disease and test potential treatments in a controlled environment.

3) They can be used to test drugs and therapies: Before new drugs or therapies are tested in humans, they are often first tested in animal models of disease. This allows researchers to assess the safety and efficacy of the treatment before moving on to human clinical trials.

4) They can provide insights into disease mechanisms: Studying disease models in animals can provide valuable insights into the underlying mechanisms of a particular disease. This information can then be used to develop new treatments or improve existing ones.

5) Reduces the need for human testing: Using animal disease models reduces the need for human testing, which can be time-consuming, expensive, and ethically challenging. However, it is important to note that animal models are not perfect substitutes for human subjects, and results obtained from animal studies may not always translate to humans.

6) They can be used to study infectious diseases: Animal disease models can be used to study infectious diseases such as HIV, TB, and malaria. These models allow researchers to understand how the disease is transmitted, how it progresses, and how it responds to treatment.

7) They can be used to study complex diseases: Animal disease models can be used to study complex diseases such as cancer, diabetes, and heart disease. These models allow researchers to understand the underlying mechanisms of the disease and test potential treatments.

8) They are cost-effective: Animal disease models are often less expensive than human clinical trials, making them a cost-effective way to conduct research.

9) They can be used to study drug delivery: Animal disease models can be used to study drug delivery and pharmacokinetics, which is important for developing new drugs and drug delivery systems.

10) They can be used to study aging: Animal disease models can be used to study the aging process and age-related diseases such as Alzheimer's and Parkinson's. This allows researchers to understand how aging contributes to disease and develop potential treatments.

The symptoms of aspergillosis depend on the location and severity of the infection. In the lungs, it may cause coughing, fever, chest pain, and difficulty breathing. In the sinuses, it can cause headaches, facial pain, and nasal congestion. In the brain, it can cause seizures, confusion, and weakness.

Aspergillosis is typically diagnosed through a combination of imaging tests such as chest X-rays, CT scans, and MRI scans, along with a biopsy to confirm the presence of Aspergillus fungi.

Treatment of aspergillosis depends on the severity and location of the infection. In mild cases, treatment may involve antifungal medications and supportive care such as oxygen therapy and pain management. In severe cases, treatment may require hospitalization and intravenous antifungal medications.

Preventive measures for aspergillosis include avoiding exposure to dusty or damp environments, managing chronic conditions such as asthma and COPD, and taking antifungal medications as prescribed.

Aspergillosis can be a serious condition, especially in people with weakened immune systems, such as those with cancer, HIV/AIDS, or taking immunosuppressive drugs. In severe cases, aspergillosis can lead to life-threatening complications such as respiratory failure, sepsis, and organ damage.

In conclusion, aspergillosis is a common fungal infection that can affect various parts of the body, and it can be serious and potentially life-threatening, especially in people with weakened immune systems. Early diagnosis and appropriate treatment are essential to prevent complications and improve outcomes.

Candida Genome Database U.S. National Institutes of Health on the Candida albicans genome Mycobank data on Candida albicans ... Candida albicans can be seen as a tautology. Candida comes from the Latin word candidus, meaning white. Albicans itself is the ... October 2005). "Characteristics of candidaemia with Candida-albicans compared with non-albicans Candida species and predictors ... Filamentation in C. albicans is a very complex process. The formation of hyphae can for example help Candida albicans to escape ...
Candida albicans). The organic extracellular matrix in calculus consists primarily of proteins and lipids (fatty acids, ...
"Immune evasion of the human pathogenic yeast Candida albicans: Pra1 is a Factor H, FHL-1 and plasminogen binding surface ... Candida albicans; Francisella tularensis; Haemophilus influenzae; Neisseria meningitidis; Streptococcus pneumoniae; and ...
... and Candida albicans. Guttate psoriasis often affects children and adolescents and can be triggered by a recent group A ...
Wingard JR (1995). "Importance of Candida species other than C. albicans as pathogens in oncology patients". Clin. Infect. Dis ... Candida lusitaniae is a species of yeast in the genus Candida. Candida lusitaniae was first identified as a human pathogen in ... Krcmery V, Barnes AJ (2002). "Non-albicans Candida spp. causing fungaemia: pathogenicity and antifungal resistance". J. Hosp. ... Candida lusitaniae was initially described as a rare cause of fungemia, with fewer than 30 cases reported between 1979 and 1990 ...
Responses to candida albicans. Complement activation. Mixed lymphocyte reaction T-cell receptors. Phagocyte function. First to ... 219-317 Foroozanfar, N., Yamamura, M. and Hobbs, J.R. Standardization of lymphocyte transformation to candida immunogen, (1974 ...
Wor1 gene in Candida albicans; structural templating in which structures are replicated using a template or scaffold structure ... "Epigenetic properties of white-opaque switching in Candida albicans are based on a self-sustaining transcriptional feedback ...
Arvind Nandedkar to study antigenic compounds associated with Candida albicans; with Dr. Robert Watkins and Dr. Arvind ... "Neuraminidase Production by Candida Albicans". Journal of the National Medical Association. 76 (2): 143-145. PMC 2561735. PMID ... "A Rapid Passive Hemagglutination Method For Demonstrating Serum Antibodies to Candida Albicans". J Natl Med Assoc. 73 (12): ... Garden in the department of Oral Surgery to study the effects of Chlorhexidine on the growth of clinical isolates of Candida ...
Candida albicans is known to selectively participate in "dual-species" biofilms with certain species of Streptococcus bacteria ... Fungal/yeast cells are also present, particularly including the genus Candida. The yeast species C. albicans and C. tropicalis ... Cannon RD, Chaffin WL (June 1999). "Oral colonization by Candida albicans". Critical Reviews in Oral Biology and Medicine. 10 ( ... Holmes AR, Cannon RD, Jenkinson HF (September 1995). "Interactions of Candida albicans with bacteria and salivary molecules in ...
Candida albicans is a kind of diploid yeast that commonly occurs among the human gut microflora. C. albicans is an ... C. albicans has a parasexual cycle that appears to be stimulated by environmental stress. Other species of Candida may be ... Bennett RJ (2015). "The parasexual lifestyle of Candida albicans". Curr. Opin. Microbiol. 28: 10-7. doi:10.1016/j.mib.2015.06. ... Candida species cause infections in individuals with deficient immune systems. Th1-type cell-mediated immunity (CMI) is ...
Schoeters, Floris; Van Dijck, Patrick (7 August 2019). "Protein-Protein Interactions in Candida albicans". Frontiers in ... Schoeters, Floris; Van Dijck, Patrick (2019). "Protein-Protein Interactions in Candida albicans". Frontiers in Microbiology. 10 ... "A CUG codon adapted two-hybrid system for the pathogenic fungus Candida albicans". Nucleic Acids Research. 38 (19): e184. doi: ... albicans genes. To provide a more native environment a C. albicans two-hybrid (C2H) system was developed. With this system ...
Datta A, Ganesan K, Natarajan K (1989). "Current Trends in Candida albicans Research". Current trends in Candida albicans ... Schaller M, Borelli C, Korting HC, Hube B (November 2005). "Hydrolytic enzymes as virulence factors of Candida albicans". ... Hube B (August 2004). "From commensal to pathogen: stage- and tissue-specific gene expression of Candida albicans". Current ... examples include Candida albicans, a dimorphic, opportunistic human pathogen, Magnaporthe grisea, a plant pathogen, and Pichia ...
... albicans/latest_assembly_versions/GCF_000182965.3_ASM18296v3". ftp.ncbi.nih.gov. Retrieved 2020-12-30. "Candida albicans (ID 21 ...
Odds also used Multi-Locus Sequence Typing (MLST) to determine the population structure of Candida albicans and other Candida ... Role of the Candida albicans MNN1 gene family in cell wall structure and virulence. Bmc Research Notes. 6: 294. PMID 23886038 ... Does Candida albicans play a role in the etiology of endometriosis? Journal of Endometriosis and Pelvic Pain Disorders. 5: 2-9 ... He studied Candida albicans, establishing how modern researchers study fungal pathogens and the diseases they cause. Frank C. ...
Schoeters F, Van Dijck P (2019). "Protein-Protein Interactions in Candida albicans". Frontiers in Microbiology. 10: 1792. doi: ...
Schoeters, F; Van Dijck, P (2019). "Protein-Protein Interactions in Candida albicans". Frontiers in Microbiology. 10: 1792. doi ... an enzyme in the umbellic acid biosynthesis pathway Candida two-hybrid (C2H) system, a variant of the yeast two-hybrid (Y2H) ...
An example of an opportunistic pathogen is Candida albicans. Candida albicans is a type of fungus/yeast found in the intestines ... Though the mechanisms Candida albicans uses to switch from being a commensal to a pathogen are largely unknown, the reasons for ... Adaptation of Candida albicans to the host environment: the role of morphogenesis in virulence and survival in mammalian hosts ... The pH of the Host Niche Controls Gene Expression in and Virulence of Candida albicans. Infect. Immun. July 1998 vol. 66 no. 7 ...
Hernández-Santos N, Gaffen SL (May 2012). "Th17 cells in immunity to Candida albicans". Cell Host & Microbe. 11 (5): 425-35. ... especially against Candida albicans. Binding of proinflammatory cytokin IL-17A to IL-17 receptor causes important ...
Aspergillus niger and Candida albicans. An increased die-off of fungal spores was found on copper surfaces compared with ... Candida utilis (formerly, Torulopsis utilis) is completely inhibited at 0.04 g/L copper concentrations. Tubercle bacillus is ... Candida utilis, Penicillium chrysogenum, Rhizopus niveus, Saccharomyces mandshuricus, and Saccharomyces cerevisiae in ...
Similar effects of MUC5B and other mucins have been demonstrated with other pathogens, such as Candida albicans, Helicobacter ... "Mucins suppress virulence traits of Candida albicans". mBio. 5 (6): e01911. doi:10.1128/mBio.01911-14. PMC 4235211. PMID ...
Candida albicans is a diploid fungus that grows both as a yeast and as a filament. C. albicans is the most common fungal ... doi:10.1007/978-1-4757-5190-1_2. ISBN 978-1-4419-3385-0. Johnson A (2003). "The biology of mating in Candida albicans". Nature ... C. albicans has maintained an elaborate, but largely hidden, mating apparatus. Johnson suggested that mating strategies may ... allow C. albicans to survive in the hostile environment of a mammalian host. Among the 250 known species of aspergilli, about ...
Sudbery, Peter; Gow, Neil; Berman, Judith (2004). "The distinct morphogenic states of Candida albicans". Trends in Microbiology ...
Magee, B. B.; P. T. Magee (2000). "Induction of Mating in Candida albicans by Construction of MTLa and MTLα Strains". Science. ... Magee and her husband have worked on the human fungal pathogen Candida albicans, and particularly their discovery of sexual ... Nantel, André (2006). "The long hard road to a completed Candida albicans genome". Fungal Genetics and Biology. 43 (5): 311-315 ... rearrangements distinguish the karyotype of the hypovirulent species Candida dubliniensis from the virulent Candida albicans". ...
In terms of the mechanism underlying its antifungal effects against Candida albicans, undecylenic acid inhibits morphogenesis. ... Undecylenic acid inhibits morphogenesis of Candida albicans. Antimicrob Agents Chemother 2000;44:2873-2875 (CS1 maint: multiple ... or other generalized infections by Candida albicans. When used for tinea cruris, it can result in extreme burning.[medical ... "Antifungal effects of undecylenic acid on the biofilm formation of Candida albicans". International Journal of Clinical ...
... mostly by Candida albicans or similar species. Treatment usually involves the administration of topical nystatin or similar ... 90% of cases are associated with Candida species, and it is the most common form of oral candidiasis. Treatment is by ...
305 In one study Candida parapsilosis was the most common species; Candida albicans is also a common agent. Onychomycosis Skin ... ISBN 0-7216-2921-0. Segal R, Kritzman A, Cividalli L, Samra Z, David M, Tiqva P (1996). "Treatment of Candida nail infection ... Candidal onychomycosis is an infection of the nail plate by fungus caused by Candida.: ...
... and Saccharomyces cerevisiae Mannan as New Biomarkers of Candida albicans Infection That Complement Tests Based on C. albicans ... In turn, Candida albicans colonization generates ASCA. According to another study, serum samples from patients with invasive ... Mannans from other yeast, for example candida albicans, have found to cross react with ASCA which suggests that other yeast may ... ASCA are serological markers of candida albicans infections in humans and animals. Mannan-binding lectin (MBL) is a lectin ...
Candida albicans Strain:SC5314, human pathogen (2004) Candida albicans Strain:WO-1, human pathogen (2009) Candida dubliniensis ... Candida guilliermondii, human pathogen (2009) Candida lusitaniae, human pathogen (2009) Candida parapsilosis, human pathogen ( ... May 2004). "The diploid genome sequence of Candida albicans". Proceedings of the National Academy of Sciences of the United ... 2009) Candida orthopsilosis, human pathogen (2012) Candida tropicalis, human pathogen (2009) Debaryomyces hansenii Strain: ...
Candida albicans is a diploid fungus that grows both as a yeast and as a filament. C. albicans is the most common fungal ... Bennett, R.J.; Johnson, A.D. (2005). "Mating in Candida Albicans and the Search for a Sexual Cycle". Annual Review of ... Mating in C. albicans is termed a parasexual cycle since meiosis is still not observed in C. albicans. A picture of the mating ... Miller, Mathew G.; Johnson, Alexander D. (2002). "White-Opaque Switching in Candida albicans is Controlled by Mating-Type Locus ...
... in Candida albicans, a fungal pathogen that causes a variety of diseases in humans. Her work has also shown that mucins found ... "Mucins suppress virulence traits of Candida albicans". mBio. 5 (6): e01911. doi:10.1128/mBio.01911-14. ISSN 2150-7511. PMC ... "Mucin O-glycans are natural inhibitors of Candida albicans pathogenicity". Nature Chemical Biology. 18 (7): 762-773. doi: ...
The main use is to control the growth of microorganisms on the dentures, especially Candida albicans, thereby preventing ...
2012). "Candida albicans scavenges host zinc via Pra1 during endothelial invasion". PLOS Pathogens. 8 (6): e1002777. doi: ... Pra1 (pH regulated antigen 1) is a candida albicans protein that scavenges host zinc. Diagnosis is typically made based on ...
Bioactive molecules extracted from its fruit have been reported to have antifungal activity in test with Candida albicans. ...
"Synthesis and Influence of 3-Amino Benzoxaboroles Structure on Their Activity against Candida albicans". Molecules. 25 (24): ... The drug is derived from Streptomyces noursei and has activity against Candida but not dermatophytes. Clinical use Nystatin is ... but the drug has no use against candida or bacteria infections. Contraindications include nail or scalp infections, and sulfa ... used topically for the treatment of Candida infections of the skin and mucous membranes. Oral Candidiasis (Oral Thrush) ...
Candida famata, Candida rugosa, Candida geotrichium, Candida dubliniensis, and Candida guilliermondii). C. albicans accounts ... Candida tropicalis, Candida glabrata, Candida parapsilosis, Candida krusei, or other species (Candida stellatoidea, Candida ... Candida albicans is the most commonly implicated organism in this condition. C. albicans is carried in the mouths of about 50% ... The causative organism is usually Candida albicans, or less commonly other Candida species such as (in decreasing order of ...
... candida MeSH B05.381.147.326 - candida albicans MeSH B05.381.147.400 - candida glabrata MeSH B05.381.147.800 - candida ... candida MeSH B05.930.176.326 - candida albicans MeSH B05.930.176.400 - candida glabrata MeSH B05.930.176.800 - candida ...
... particularly Candida albicans), or nematode. Irritation Discomfort or pain Foreign-body sensation Tearing Blepharospasm ...
Swidergall, Marc; Ernst, Joachim F. (August 2014). "Interplay between Candida albicans and the Antimicrobial Peptide Armory". ... Isolation, characterization, primary structure, and fungistatic effects on Candida albicans". The Journal of Biological ... The antifungal properties of histatins have been seen with fungi such as Candida glabrata, Candida krusei, Saccharomyces ... "Innate immune cell response upon Candida albicans infection". Virulence. 7 (5): 512-26. doi:10.1080/21505594.2016.1138201. PMC ...
Schizosaccharomyces pombe and Candida albicans". FEMS Yeast Research. 14 (1): 119-135. doi:10.1111/1567-1364.12113. ISSN 1567- ...
The chlamydospores of Candida albicans: comparison of three media for their induction. Jour. Lab. & Clin. Med. 1957. (in press- ... Candida (Monilia) albicans. Benham further described characteristics that may be used to distinguish this species from others ... Species of Candida most frequently isolated from man: methods and criteria for their identification. Jour. Chronic Dis. 5: 460- ... Her most renowned works include her publications on the genus Candida, which established her as an authority on the yeast-like ...
However, some of the best known representatives of Debaryomycetaceae - Candida albicans and its closest relatives - contain the ... The bZIP intron candida is an unconventional bZIP intron located in the HAC1 mRNA in a subgroup of fungi from Saccharomycetales ... Splicing performed by Ire1 results in excision of a very long intron that was first described in Candida parapsilosis. Hooks KB ... "Identification of an Exceptionally Long Intron in the HAC1 Gene of Candida parapsilosis". mSphere. 3 (6). doi:10.1128/mSphere. ...
... candida Hinds, 1843: synonym of Glyphostoma candida (Hinds, 1843) Clavatula candida (Philippi, 1848): synonym of ... 1932 Species brought into synonymy Clavatula albicans Hinds, 1843: synonym of Splendrillia albicans (Hinds, 1843) Clavatula ...
Murciano C, Villamón E, Yáñez A, O'Connor JE, Gozalbo D, Gil ML (December 2006). "Impaired immune response to Candida albicans ...
Candida albicans, Yarrowia lipolytica, Pichia pastoris, Candida parapsilosis Animals: human, mouse and Caenorhabditis elegans, ... of Candida albicans" (PDF). Fungal Genet Biol. 45 (9): 1235-1247. doi:10.1016/j.fgb.2008.06.001. PMID 18602013. Oh MH, Cheon SA ... "Identification of an Exceptionally Long Intron in the HAC1 Gene of Candida parapsilosis". mSphere. 3 (6). doi:10.1128/mSphere. ... but experimental studies showed it is also present in Basidiomycota and other Candida species. All 45 vertebrate genomes ...
Akbari, Freshta; Kjellerup, Birthe (2015). "Elimination of Bloodstream Infections Associated with Candida albicans Biofilm in ... line-associated blood stream infection Staphylococcus aureus Methicillin resistant Staphylococcus aureus Candida albicans ... Enterobacter and Candida spp. The goal of hand hygiene is to eliminate the transient flora with a careful and proper ...
"D-arabitol metabolism in Candida albicans: studies of the biosynthetic pathway and the gene that encodes NAD-dependent D- ... and characterization of a D-arabinitol-specific dehydrogenase from Candida tropicalis". Biochem. Biophys. Res. Commun. 196 (3 ...
Candida albicans is a species of fungus that is associated with oral thrush and gastrointestinal infection. Coccidioides ...
Candida albicans SC5314 Canis familiaris (dog) Cavia porcellus (guinea pig) Chlamydomonas reinhardtii (green algae) Chlorocebus ...
It is also active against the fungus Candida albicans, but has no activity against Pseudomonas aeruginosa. Hepcidin synthesis ...
... of Candida albicans is also involved in septation and cytokinesis, but not mitotic exit. Studies of Cdc14 in animal ...
Streptococcus and Candida albicans. Traditional strategies to combat infections aim at decreasing skin colony count such as ...
3, 1883, ISSN 0005-8041, S. 377-433, hier S. 403 ff". Navarathna, D. (2016). "Candida albicans ISW2 Regulates Chlamydospore ... Hülle cell like structures are known such as in Candida albicans which produce at the very end of the hyphae globose blisters ...
2000). "The Candida albicans gene for mRNA 5-cap methyltransferase: identification of additional residues essential for ... Saha N, Schwer B, Shuman S (1999). "Characterization of human, Schizosaccharomyces pombe, and Candida albicans mRNA cap ...
Wor3 domains, named after the White-Opaque Regulator 3 (Wor3) in Candida albicans arose more recently in evolutionary time than ...
Herpes simplex virus, Adenovirus, Cytomegalovirus[citation needed] Candida Albicans Parasitic causes include Trichomonas ...
... is an opportunistic infection of the esophagus by Candida albicans. The disease usually occurs in ... A severe case of candidiasis H&E stain of esophagus showing Candida hyphae within the lamina propria The current first-line ... Brushing or biopsy of the plaques shows yeast and pseudohyphae by histology that are characteristic of Candida species. ... "Predisposing factors and clinical symptoms in HIV-negative patients with Candida oesophagitis: are they always present?". ...
"Rare infection of implantable cardioverter-defibrillator lead with Candida albicans: case report and literature review". Ther ...
Penicillium species, Aspergillus niger and Candida albicans are used in the pharmaceutical industry for microbial limit testing ... They also found that the three major groups of fungi that they found, hyphomycetes, dermatophytes and Candida relatives, could ... albicans. Cudowski et al. found that they could determine whether a sample of water had been taken from the natural (lake-like ...
Candida albicans Endocarditis Associated with a Contaminated Aortic Valve Allograft -- California, 1996 An allograft heart ... Cultures of blood specimens drawn on admission were positive for Candida albicans, and the next day, amphotericin B and 5- ... Characterization and partial nucleotide sequence of the DNA fingerprinting probe Ca3 of Candida albicans. J Clin Microbiol 1993 ... Computer-assisted methods for assessing strain relatedness in Candida albicans by fingerprinting with the moderately repetitive ...
Candida infection of the skin ... fungus that most often causes cutaneous candidiasis is Candida albicans . Candida is the most ... It is most commonly due to the fungus Candida albicans . ... have a vaginal yeast infection at some time. Candida albicans is a ... infections are most often due to the fungus Candida albicans . Candida and the many other germs that normally live ... ... Candidal diaper dermatitis is caused when Candida albicans, a common type of yeast that is normally found in the mouth and ...
... was investigated against 50 clinical isolates of Candida albicans (28 oropharyngeal strains, 22 vaginal strains) and C. ... Antifungal activity of Lavandula angustifolia essential oil against Candida albicans yeast and mycelial form Med Mycol. 2005 ... was investigated against 50 clinical isolates of Candida albicans (28 oropharyngeal strains, 22 vaginal strains) and C. ... Lavender oil (2%) killed 100% of the C. albicans ATCC 3153 cells within 15 min; linalool (0.5%) killed 100% of the cells within ...
In this chapter, the method to determine the persister fraction in a C. albicans biofilm treated with an antifungal compound is ... albicans biofilms can contain a persister subpopulation that is tolerant to high concentrations of currently used antifungals. ... In contrast to planktonic cultures of the human fungal pathogen Candida albicans, C. ... In contrast to planktonic cultures of the human fungal pathogen Candida albicans, C. albicans biofilms can contain a persister ...
Candida albicans Rebecca A. Drummond, University of Birmingham, UK Candida albicans is a normal part of the human commensal ... C. albicans commonly lives in the human gut therefore invasion of the gut wall by C. albicans (for example, through an ulcer or ... Figure 1. The three morphological forms of Candida albicans. Yeast (1) are small, round cells that divide by conventional cell ... Immunity to C. albicans. A crucial component in the defence against C. albicans is the pattern recognition receptor, Dectin-1 ...
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Centers RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.. ...
99mTc-Labeled Antimicrobial Peptides for Detection of Bacterial and Candida albicans Infections. Satya S. Das, David W. Wareham ... 99mTc-Labeled Antimicrobial Peptides for Detection of Bacterial and Candida albicans Infections ... 99mTc-Labeled Antimicrobial Peptides for Detection of Bacterial and Candida albicans Infections ... 99mTc-Labeled Antimicrobial Peptides for Detection of Bacterial and Candida albicans Infections ...
To infect host tissue, the usual unicellular yeast-like form of C. albicans reacts to environmental cues and switches into an ... Among the many bugs that live in the mouth and digestive tract is the yeast Candida albicans, which under normal circumstances ... How Candida albicans switches phenotype - and back again - Coffee Break. How Candida albicans switches phenotype - and back ... How Candida albicans switches phenotype - and back again. the SIR2 silencing gene has a say in Candidas colony type ...
ACETALDEHYDE OR 51-84-3 OR CAFFEIC ACID OR CANDIDA ALBICANS OR CH... (13860) ACETALDEHYDE OR 51-84-3 OR CAFFEIC ACID OR CANDIDA ... Did you mean: acetaldehyde OR 51-84-3 OR caffeic acid OR candida albicans OR chlorogenic acid OR cinnamic acid OR coumarin OR ... Did you mean: acetaldehyde OR 51-84-3 OR caffeic acid OR candida albicans OR chlorogenic acid OR cinnamic acid OR coumarin OR ... "albicans"[All Fields]) OR "candida albicans"[All Fields]) OR (("chlorogenic"[All Fields] AND "acid"[All Fields]) OR " ...
CANDIDA ALBICANS (UNII: 4D7G21HDBC) (CANDIDA ALBICANS - UNII:4D7G21HDBC) CANDIDA ALBICANS. 16 [hp_X] in 1 mL. ... CANDIDA PARAPSILOSIS (UNII: 0KZ676D44N) (CANDIDA PARAPSILOSIS - UNII:0KZ676D44N) CANDIDA PARAPSILOSIS. 16 [hp_X] in 1 mL. ... Candida Albicans 16X, 60X, 100X, Candida Parapsilosis 16X, 60X, 100, Dust 16X, 60X, 100, Mucor Racemosus 16X, 60X, 100, Torula ... candida albicans, candida parapsilosis, dust, mucor racemosus, torula cerevisiae, house dust mite, adrenocorticotrophin, ...
We have used a range of isogenic glycosylation mutants of C. albicans, which are defective to varying degrees in cell wall ... The outermost layer of the Candida albicans cell wall is enriched with mannosylated glycoproteins. ... Netea M. G., Brown G. D., Kullberg B. J., Gow N. A. R. 2008; An integrated model of pattern recognition of Candida albicans in ... Klis F. M., de Groot P., Hellingwerf K. 2001; Molecular organization of the cell wall of Candida albicans . Med Mycol 39 :Suppl ...
The fungus Candida albicans colonizes the oral mucosal surface of 30-70% of healthy individuals. Due to local or systemic ... albicans causes no harm. Unlike humans mice do not host C. albicans in their mycobiome. Thus, oral fungal challenge generates ... Therefore, we utilized C. albicans clinical isolates which are able to persist in the oral cavity without causing disease to ... Besides CD19+ CD138- B cells, plasmablasts, and plasma cells were enriched in the tongue of mice colonized with C. albicans ...
The aim of this study was to evaluate the microbial interactions between Streptococcus mutans and Candida albicans in vitro and ... Avaliação dos efeitos de Streptococcus mutans sobre formação de biofilme e morfogênese de Candida albicans in vitro e estudo ... Avaliação dos efeitos de Streptococcus mutans sobre formação de biofilme e morfogênese de Candida albicans in vitro e estudo ... O objetivo desse estudo foi avaliar as interações microbianas entre Streptococcus mutans e Candida albicans em modelos de ...
05273 from Candida albicans WO-1 . Plus protein sequence and external database links. ... CAWG_05273 , Candida albicans WO1 conserved hypothetical protein (230 aa). Sequence. ... Domain assignment for CAWT_05273 from Candida albicans WO-1 Domain architecture ...
Genotoxic effect of photodynamic therapy mediated by curcumin on Candida albicans. Author(s): *Carmello, Juliana Cabrini ... formation in the form of singlet oxygen and DNA damage of Candida albicans. Surprisingly, CUR-mediated PDT but also light alone ... caused significantly longer comet tails, an indication of DNA damage of C. albicans when compared with the negative control. ...
Although AC-PACs did not affect growth of C. albicans, it prevented biofilm formation and reduced adherence of C. albicans to ... The effects of AC-PACs on C. albicans-induced cytokine secretion, nuclear factor-kappa B (NF-κB) p65 activation and kinase ... Microplate dilution assays were performed to determine the effect of AC-PACs on C. albicans growth as well as biofilm formation ... Adhesion of FITC-labeled C. albicans to oral epithelial cells and to acrylic resin disks was monitored by fluorometry. ...
Candida albicans je druh kvasinkovej huby, ktorá sa bežne nachádza v zdravej ľudskej bakteriálnej flóre. V najväčšom množstve ...
... ... Evaluation of the antifungal activity of Ficus bengalensis against Candida albicans; an experimental study; International ... was conducted to determine the antifungal activity of Ficus bengalensis against the laboratory specimens of Candida albicans. ...
Candeva, our natural formula, succeeds in addressing overgrowth of fungal infections (Candida) through natural means.
In understanding Candida Albicans, you have to know the common factors that encourage the overgrowth of Candida. The most ... Understanding Candida Albicans behavior is important to help you prevent the occurrence of infection. Although Candida fungus ... understanding Candida Albicans will help you figure out why you are suffering from recurring yeast infection. Candida is yeast ... Understanding Candida Albicans is the key to stop the infection from its root cause. To get rid of the infection for good, the ...
There are a act of room to kickshaw candida albicans, admit dietary modify, supplement, and prescription medicament. ... a candida albicans overgrowth is make by an imbalance in the bodys instinctive bacteria. This can be due to a numerate of ... how do you treat candida albicans?. how do you treat candida albicans? According to the University of Maryland Medical Center, ... There are a number of ways to treat candida albicans, including dietary changes, supplementation, and prescription medications. ...
Candida albicans, and Aspergillus niger. Tailor antibiotic therapy based on culture sensitivities. ... Fungi (Candida albicans, Aspergillus niger). See the list below:. * Clotrimazole 1% otic solution 4 drops in the affected ear ... Candida albicans, and Aspergillus niger. Tailor antibiotic therapy based on culture sensitivities. [1, 2, 3, 4, 5, 6, 7, 8] ...
BIO 82 , Fungal Infection, Candida Albicans. BIO 82 , Fungal Infection, Candida Albicans ... Candida Albicans Increase quantity for BIO 82 , Fungal Infection, Candida Albicans ... Aspergillus niger D30, Candida albicans D12, Chlamydia trachomatis D30, Echinacea D12, Penicillinum D30, Tecoma radicans D30, ... Aspergillus niger, Candida albicans, Penicillinum: These ingredients provide antigenic or nosodal relief, by stimulating the ...
SOUSA, João Nilton Lopes de et al. Photoinactivation of Candida albicans using methylene blue as photosensitizer. RGO, Rev. ... Keywords : Candida albicans.; Methylene blue.; Photochemotherapy.. · abstract in Portuguese · text in English · pdf in English ... Objective To evaluate the effect of photodynamic therapy in the inactivation of Candida albicans planktonic cells, using ... Conclusion Photodynamic Therapy presented antifungal effect against Candida albicans and can be used as an adjunct to ...
CANDIDA ALBICANS (UNII: 4D7G21HDBC) (CANDIDA ALBICANS - UNII:4D7G21HDBC) CANDIDA ALBICANS. 1 U in 0.1 mL. ... CANDIN- candida albicans skin test antigen injection, solution. Out of scope - Out of scope for RxNorm and will not receive ... CANDIN- candida albicans skin test antigen injection, solution. To receive this label RSS feed. Copy the URL below and paste it ... Candida albicans Skin Test Antigen For Cellular Hypersensitivity CANDIN intradermal injection Initial U.S. Approval 1995 ...
... and provided adequate information about the carcinogenesis parameters of Candida albicans in oral cancer. Candida albicans in ... Role of Candida albicans in Oral Carcinogenesis. Ayuningtyas, Nurina Febriyanti; Mahdani, Fatma Yasmin; Pasaribu, Togu Andrie ... Candida albicans is a member oral microbiota that acts as an opportunistic pathogen along with changes in the epithelium that ... Candida albicans have a role in the process of oral carcinogenesis concerning morphological phenotype changes in cell structure ...
Candida albicans (2762). -. -. 4 - ?. Caspofungin (MK-0991). 588. This project is supported by TOKU-E which specializes in ...
Candida albicans Cho1p, the lipid biosynthetic enzyme with the most potential as a drug target, has been biochemically ... are crucial for Candida albicans virulence. Mutations that disrupt these enzymes compromise virulence. These enzymes are part ... Role of phosphatidylserine synthase in shaping the phospholipidome of Candida albicans , FEMS Yeast Research , vol. 17 , no. ... Understanding how losses of PS and/or PE synthesis pathways affect the phospholipidome of Candida is important for fully ...
Further, we also aimed to assess the potential of C. albicans in the Candida-bacteria polymicrobial biofilm to elicit cytokine ... C. albicans cell counts increased significantly up to 48 h in polymicrobial biofilms (p < 0.05), while the bacterial counts ... However, the presence of bacteria in the biofilm did not seem to affect the growth of C. albicans. Expression of IL-8 gene was ... Even though growth and interaction of C. albicans with certain bacterial species has been studied, little is known about its ...
... and Candida albicans is the major cause of infections in humans. The Clinical and Laboratory Standards Institute (CLSI) ... C. albicans were identified by using API 20C AUX system. Broth microdilution method was used to determine the minimum ... Results: Overall, 397 C. albicans were isolated from patients admitted to ten university hospitals in Iran. The MIC90 of the ... In this multi-center study, we aimed to determine the drug susceptibility profile of C. albicans, isolated from Iranian ...
  • In contrast to planktonic cultures of the human fungal pathogen Candida albicans, C. albicans biofilms can contain a persister subpopulation that is tolerant to high concentrations of currently used antifungals. (medworm.com)
  • The human pathogen Candida albicans is considered an obligate commensal of animals, yet it is occasionally isolated from trees, shrubs, and grass. (nih.gov)
  • Furthermore, Bay 11-7085 exhibited potency against Candida albicans and the emerging pathogen Candida auris with a MIC of 0.5-1 μg/ml. (houstonmethodist.org)
  • Candida albicans is an opportunistic, fungal pathogen of humans that frequently causes superficial infections of oral and vaginal mucosal surfaces of debilitated and susceptible individuals. (bvsalud.org)
  • The aim of this study was to investigate the effects of A-type cranberry proanthocyanidins (AC-PACs) on pathogenic properties of C. albicans as well as on the inflammatory response of oral epithelial cells induced by this oral pathogen. (biomedcentral.com)
  • AC-PACs by affecting the adherence properties of C. albicans and attenuating the inflammatory response induced by this pathogen represent potential novel therapeutic agents for the prevention/treatment of oral candidiasis. (biomedcentral.com)
  • For example, these substances have been shown to kill the bacteria Staphylococcus Aureus (a very dangerous pathogen) and the yeast Candida Albicans, a common source of yeast infections in humans ( 10 ). (nutritionbreakthroughs.com)
  • Candida albicans is a common type of fungus. (nih.gov)
  • yeast infection, is an overgrowth of the common Candida albicans fungus, which is naturally found in the environment and on the body. (nih.gov)
  • The fungus Candida albicans colonizes the oral mucosal surface of 30-70% of healthy individuals. (escholarship.org)
  • Candida is yeast, a type of fungus which is the most frequent cause of candidiasis. (dp.ua)
  • Although Candida fungus live in the human body it is harmless if kept in check, however if it became uncontrollable or if it grows rapidly then candidiasis or yeast infection occurs. (dp.ua)
  • Antibiotics disrupt the normal human flora and encourage the proliferation of Candida fungus resulting to candidiasis. (dp.ua)
  • Candida fungus feeds on sugar so you have to starve the fungus and limit your sugar intake to stop yeast infection. (dp.ua)
  • Candida albicans is a commensal fungus that colonizes the oral cavity and various other sites in human body. (biomedcentral.com)
  • Symptoms start in childhood and may include hormonal problems and frequent infections of the mouth and the skin by the fungus Candida . (nih.gov)
  • The C. albicans isolates, obtained from valve trimmings during processing and when the valve was removed from the recipient, were highly similar by DNA fingerprinting using Southern blot hybridization with the DNA probe Ca3 (4,5). (cdc.gov)
  • lavender oil) and its main components, linalool and linalyl acetate, was investigated against 50 clinical isolates of Candida albicans (28 oropharyngeal strains, 22 vaginal strains) and C. albicans ATCC 3153. (nih.gov)
  • Therefore, we utilized C. albicans clinical isolates which are able to persist in the oral cavity without causing disease to analyze adaptive responses to oral fungal commensalism. (escholarship.org)
  • In Group I, 49 of the total 66 (74.2%) isolates of Candida were significant, suggesting that three in every four Candida isolated from blood can be significant. (who.int)
  • The organisms included 105 isolates previously identified as C. albicans, 10 reference strains of C. albicans, 2 reference strains of C. dubliniensis and 102 fresh clinical isolates identified as C. albicans. (who.int)
  • Candida albicans is a normal part of the human commensal flora, however it is also the most common fungal species that can cause human disease. (immunology.org)
  • Mucosal IgA Prevents Commensal Candida albicans Dysbiosis in the Oral Cavity. (escholarship.org)
  • Thus, in the oral cavity B lymphocytes contribute to control commensal C. albicans carriage by secreting IgA at foci of colonization thereby preventing fungal dysbiosis. (escholarship.org)
  • Frequently, it is changes in host factors that lead to Candida seemingly changing from a commensal to pathogenic existence. (bvsalud.org)
  • The aim of this review is to provide an overview of some of the possible interactions that may occur between C. albicans and host epithelial surfaces that may in turn dictate whether Candida removal, its commensal persistence or infection follows. (bvsalud.org)
  • Candida albicans is a commensal microorganism that colonizes the oral cavity of a large proportion of humans. (biomedcentral.com)
  • If you have a Candida overgrowth , the topical creams will not do any good. (candida-albicans-cure.com)
  • Although in most cases this yeast does not cause any harmful effects, an overgrowth of C. albicans may result in candidiasis. (biomedcentral.com)
  • Overgrowth of Candida Albicans is the common cause of oral thrush, esophagus candidiasis, vaginal candidiasis and penile candidiasis. (dp.ua)
  • In understanding Candida Albicans, you have to know the common factors that encourage the overgrowth of Candida. (dp.ua)
  • Candida overgrowth can become pathogenic or it can cause disease in people with compromised immune system. (dp.ua)
  • According to the University of Maryland Medical Center, a candida albicans overgrowth is caused by an imbalance in the body's natural bacteria. (themilkcleanse.com)
  • In the in vitro study, the effects of S. mutans on biofilm formation and on the filamentation ability by C. albicans were evaluated. (unesp.br)
  • In vitro results showed that cells of S. mutans favored biofilm formation by C. albicans, however when C. albicans was put in contact with the only supernatant of a culture of S. mutans, there was a reduction in biofilm formation and inhibition of the morphological transition of C. albicans. (unesp.br)
  • Bay 11-7085 partially inhibited and eradicated biofilm formation of various pathogens, such as VRSA (vancomycin-resistant S. aureus), as well as antifungal-resistant Candida spp. (houstonmethodist.org)
  • Microplate dilution assays were performed to determine the effect of AC-PACs on C. albicans growth as well as biofilm formation stained with crystal violet. (biomedcentral.com)
  • Although AC-PACs did not affect growth of C. albicans , it prevented biofilm formation and reduced adherence of C. albicans to oral epithelial cells and saliva-coated acrylic resin discs. (biomedcentral.com)
  • Lavender oil shows both fungistatic and fungicidal activity against C. albicans strains. (nih.gov)
  • We generated genome sequence data for three strains of C. albicans that we isolated from oak trees in an ancient wood pasture, and compared these to the genomes of over 200 clinical strains. (nih.gov)
  • C. albicans strains from oak are similar to clinical C. albicans in that they are predominantly diploid and can become homozygous at the mating locus through whole-chromosome loss of heterozygosity. (nih.gov)
  • However, given the often reported heterogeneity in morphological and biochemical factors that exist between Candida species and indeed strains of C. albicans, it may also be the fact that colonising strains differ in the way they exploit resources to allow persistence at mucosal surfaces and as a consequence this too may affect the way Candida interacts with epithelial cells . (bvsalud.org)
  • Candida growth and biofilm development have been suppressed using certain types of probiotics, particularly strains of the Lactobacillus genus. (superfoodly.com)
  • Staphylococcus aureus and Candida spp. (houstonmethodist.org)
  • Organism-specific therapeutic regimens for otitis externa are provided below, including those for Pseudomonas aeruginosa, Staphylococcus aureus , Candida albicans , and Aspergillus niger . (medscape.com)
  • The aim was to evaluate the growth of C. albicans in polymicrobial biofilms comprising oral Gram-negative and Gram-positive bacteria. (biomedcentral.com)
  • On the contrary, TNF-α expression was significantly higher in biofilms than in supernatants but was very low (1-4 folds) in the monospecies biofilm of C. albicans . (biomedcentral.com)
  • Persistence and enhanced growth of C. albicans in polymicrobial biofilms may imply that previously reported antagonistic effect of A. actinomycetemcomitans was negated. (biomedcentral.com)
  • Increased cytokine gene expression and cytokine production induced by Candida -bacteria polymicrobial biofilms and biofilm supernatants suggest that together they possibly exert an enhanced stimulatory effect on IL-8 and TNF-α production from the host. (biomedcentral.com)
  • However, there is a dearth of knowledge on cytokine-inducing potential of Candida -bacteria polymicrobial biofilms and biofilm-supernatants containing soluble secreted components from biofilms. (biomedcentral.com)
  • At lower concentrations, it inhibits germ tube formation and hyphal elongation, indicating that it is effective against C. albicans dimorphism and may thus reduce fungal progression and the spread of infection in host tissues. (nih.gov)
  • In vivo study, were inoculated S. mutans together with C. albicans in larvae of G. mellonella for induction of experimental infection. (unesp.br)
  • Finally, Bay 11-7085 was effective in vivo at increasing the lifespan of C. elegans during an S. aureus and a C. albicans infection. (houstonmethodist.org)
  • A quick way to get rid of your systemic infection is to use one of the Candida albicans medications. (candida-albicans-cure.com)
  • What may seem like a short term problem may actually be symptoms of a systemic Candida albican infection. (candida-albicans-cure.com)
  • You can completely cure yourself but if the cause is still there, you will get another Candida infection as soon as you stop the treatment. (candida-albicans-cure.com)
  • In a person with a systemic Candida albicans infection, excess carbs actually suppress energy. (candida-albicans-cure.com)
  • If you are experiencing chronic yeast infection or candidiasis, understanding Candida Albicans will help you figure out why you are suffering from recurring yeast infection. (dp.ua)
  • Understanding Candida Albicans behavior is important to help you prevent the occurrence of infection. (dp.ua)
  • Understanding Candida Albicans is the key to stop the infection from its root cause. (dp.ua)
  • Interaction of C. albicans with oral bacteria is crucial for its persistence, but also plays a potential role in the infection process. (biomedcentral.com)
  • 2. EGFR and HER2 receptor kinase signaling mediate epithelial cell invasion by Candida albicans during oropharyngeal infection. (nih.gov)
  • 3. The Globular C1q Receptor Is Required for Epidermal Growth Factor Receptor Signaling during Candida albicans Infection. (nih.gov)
  • 17. Candida albicans-epithelial interactions: dissecting the roles of active penetration, induced endocytosis and host factors on the infection process. (nih.gov)
  • A delicate balance clearly exists between the potentially damaging effects of Candida virulence factors and the nature of the immune response elicited by the host. (bvsalud.org)
  • 4. Activation of EphA2-EGFR signaling in oral epithelial cells by Candida albicans virulence factors. (nih.gov)
  • Objective To evaluate the effect of photodynamic therapy in the inactivation of Candida albicans planktonic cells, using methylene blue, 150 mg/mL, as a photosensitizer. (bvsalud.org)
  • C. albicans can also colonise the mouth (oral candidiasis) and can be a problem in newborns and the elderly. (immunology.org)
  • C. albicans commonly lives in the human gut therefore invasion of the gut wall by C. albicans (for example, through an ulcer or wound) is thought to one way in which disseminated candidiasis can start. (immunology.org)
  • The effects of S. mutans on experimental candidiasis in G. mellonella was evaluated by analysis of the survival curve, the study of the culture of hemolymph for quantification of C. albicans and by histological evaluation the formation of hyphae of C. albicans in the host tissues. (unesp.br)
  • Oral candidiasis is a common fungal disease mainly caused by Candida albicans . (biomedcentral.com)
  • More specifically, denture stomatitis is a common form of candidiasis affecting denture wearers and characterized by an inflammation of the oral mucosal areas induced by C. albicans [ 2 ]. (biomedcentral.com)
  • Several virulence properties of C. albicans , which contribute to the development of oral candidiasis have been identified. (biomedcentral.com)
  • 55 adults harboring Candida yeast but with no clinical symptoms of oral candidiasis. (superfoodly.com)
  • 11. Perspective on receptor-associated immune response to Candida albicans single and mixed infections: Implications for therapeutics in oropharyngeal candidiasis. (nih.gov)
  • 15. Candida albicans White-Opaque Switching Influences Virulence but Not Mating during Oropharyngeal Candidiasis. (nih.gov)
  • In this chapter, the method to determine the persister fraction in a C. albicans biofilm treated with an antifungal compound is described. (medworm.com)
  • This study was conducted to determine the antifungal activity of Ficus bengalensis against the laboratory specimens of Candida albicans. (ijsrp.org)
  • Conclusion Photodynamic Therapy presented antifungal effect against Candida albicans and can be used as an adjunct to conventional treatment. (bvsalud.org)
  • The aim of this study was to evaluate the microbial interactions between Streptococcus mutans and Candida albicans in vitro and in an experimental model of Galleria mellonella. (unesp.br)
  • Interactions of Candida albicans with host epithelial surfaces. (bvsalud.org)
  • C. albicans coexists with a multitude of bacterial species [ 3 ] and its interactions with streptococci are often mutually beneficial for their survival in diverse oral niches [ 2 ]. (biomedcentral.com)
  • We investigated the potential of sublethal PDT using light-sensitive curcumin (CUR) in combination with blue (455 nm) light to promote reactive oxygen species (ROS) formation in the form of singlet oxygen and DNA damage of Candida albicans. (unesp.br)
  • That's exactly what many women and men suffer from, when it comes to the Candida albicans species. (superfoodly.com)
  • In a prospective analysis, blood from 660 neonates admitted to neonatal Intensive Care Unit (NICU) of a teaching hospital with clinical suspicion of septicemia was cultured to look for etiological agents with particular reference to role of Candida species. (who.int)
  • Because only two PIR genes (PIR1, PIR32) were annotated in the Candida albicans genome, the initial goal of this work was to construct a true & UDelta,pir/& UDelta,pir null strain in this species. (cas.cz)
  • The Pir family is greatly expanded in C. albicans and C. dubliniensis compared to other species and the orthologs are known to have specialized function during chlamydospore formation. (cas.cz)
  • Even though growth and interaction of C. albicans with certain bacterial species has been studied, little is known about its biofilm growth in vitro in the simultaneous presence of Gram-negative and Gram-positive bacteria. (biomedcentral.com)
  • Notably, Bay 11-7085 partially inhibited initial cell attachment and formation of a VRSA-C. albicans polymicrobial biofilm in vitro. (houstonmethodist.org)
  • Further, we also aimed to assess the potential of C. albicans in the Candida -bacteria polymicrobial biofilm to elicit cytokine gene expression and cytokine production from human blood cells. (biomedcentral.com)
  • Aspergillus niger, Candida albicans, Penicillinum: These ingredients provide antigenic or nosodal relief, by stimulating the defense mechanism of the body. (microcellsciences.com)
  • Cultures of blood specimens drawn on admission were positive for Candida albicans, and the next day, amphotericin B and 5-fluorocytosine therapy was initiated. (cdc.gov)
  • Blood culture specimens from two different sites at same time were obtained to rule out possibility of a Candida isolate being a mere contaminant. (who.int)
  • In group I, Candida was isolated from 66 neonates, of these 49 grew Candida in both specimens (significant candidemia). (who.int)
  • Majority were non-albicans Candida (germ tube test negative - 76/90). (who.int)
  • Non-albicans Candida are emerging as important pathogens for neonatal septicemia. (who.int)
  • Furthermore, the effects of the S. mutans were tested on C. albicans at different stages of growth of the bacterial culture (4, 6, 18 and 24 h). (unesp.br)
  • Both the essential oil and its main components inhibited hyphal elongation of C. albicans ATCC 3153 (about 50% inhibition at 0.016% with each substance). (nih.gov)
  • In contrast to C. albicans, inhibition of VRSA biofilm was linked to initial cell attachment independent of its bactericidal activity. (houstonmethodist.org)
  • For yeast infections and athlete's foot , there are Candida albicans medicines that can be applied topically and there are Candida albicans medicines that you take internally. (candida-albicans-cure.com)
  • Candida albicans Cho1p, the lipid biosynthetic enzyme with the most potential as a drug target, has been biochemically characterized, and analysis of its substrate specificity and kinetics reveal that these are similar to those previously published for Saccharomyces cerevisiae Cho1p. (st-andrews.ac.uk)
  • The findings indicated that antimicrobial processing of the initial aortic valve allograft did not eliminate C. albicans from the tissue. (cdc.gov)
  • Pathway analysis revealed an upregulation of adaptive host responses due to C. albicans oral persistence, including the upregulation of the immune network for IgA production. (escholarship.org)
  • Besides CD19 + CD138 - B cells, plasmablasts, and plasma cells were enriched in the tongue of mice colonized with C. albicans suggesting a potential role of B lymphocytes during oral fungal colonization. (escholarship.org)
  • The oral Candida albicans medicines are man-made antifungals so they go right to the source. (candida-albicans-cure.com)
  • Adhesion of FITC-labeled C. albicans to oral epithelial cells and to acrylic resin disks was monitored by fluorometry. (biomedcentral.com)
  • The effects of AC-PACs on C. albicans -induced cytokine secretion, nuclear factor-kappa B (NF-κB) p65 activation and kinase phosphorylation in oral epithelial cells were determined by immunological assays. (biomedcentral.com)
  • In addition, AC-PACs significantly decreased the secretion of IL-8 and IL-6 by oral epithelial cells stimulated with C. albicans . (biomedcentral.com)
  • 16. Potential role of Candida albicans secreted aspartic protease 9 in serum induced-hyphal formation and interaction with oral epithelial cells. (nih.gov)
  • Unlike humans mice do not host C. albicans in their mycobiome. (escholarship.org)
  • Dectin-1 is required for the efficient phagocytosis and killing of C. albicans , because it binds β-glucans which form a layer within the C. albicans cell wall. (immunology.org)
  • 18. Als3 is a Candida albicans invasin that binds to cadherins and induces endocytosis by host cells. (nih.gov)
  • Candida albicans Pmr1p, a secretory pathway P-type Ca 2+ /Mn 2+ -ATPase, is required for glycosylation and virulence. (microbiologyresearch.org)
  • O objetivo desse estudo foi avaliar as interações microbianas entre Streptococcus mutans e Candida albicans em modelos de biofilmes formados in vitro e em modelo experimental de Galleria mellonella. (unesp.br)
  • Bioinformatic approaches revealed nine additional C. albicans proteins that share a conserved Pir functional motif (minimally DGQ). (cas.cz)
  • 8. Receptor-kinase EGFR-MAPK adaptor proteins mediate the epithelial response to Candida albicans via the cytolytic peptide toxin, candidalysin. (nih.gov)
  • No estudo in vitro, foram avaliados os efeitos de S. mutans sobre a formação de biofilme por C. albicans e sobre a capacidade de filamentação de C. albicans. (unesp.br)
  • Candida albicans medicines are discussed in Chapter 6 in the book "Candida Albicans - The Hidden Disease" . (candida-albicans-cure.com)
  • Candida was isolated from total 90 neonates (isolation rate 13.6%) and it was the single most common isolate. (who.int)
  • A crucial component in the defence against C. albicans is the pattern recognition receptor, Dectin-1 and its signaling molecule, CARD9 . (immunology.org)
  • Phosphatidylserine (PS) synthase (Cho1p) and the PS decarboxylase enzymes (Psd1p and Psd2p), which synthesize PS and phosphatidylethanolamine (PE), respectively, are crucial for Candida albicans virulence. (st-andrews.ac.uk)
  • Candidalysin is a toxin secreted by hyphae that damages epithelial cells, and thus may allow C. albicans to penetrate barrier tissues and establish infections. (immunology.org)
  • As molecular tests are currently unsuitable for use in routine diagnostic laboratories, we compared a variety of phenotypic techniques for differentiating C. albicans and C. dubliniensis. (who.int)
  • This occurs when a patient is immunosuppressed (due to immunosuppressive drugs, chemotherapy or neutropenia) and C. albicans, normally kept under control by the immune system, invades tissues and enters the bloodstream. (immunology.org)
  • Taking a mineral supplement helps build up your immune system to fight the Candida. (candida-albicans-cure.com)
  • You also have to know that Candida has intense need for carbohydrates and sugar. (dp.ua)
  • A diet high in carbohydrates and sugar is not only fattening but it also encourages the propagation of Candida Albicans. (dp.ua)
  • Candida albicans , and enteric gram-negative organisms. (medscape.com)
  • Para a realização do estudo in vivo, pela primeira vez na literatura, foram inoculados S. mutans juntamente com C. albicans em lagartas de G. mellonella para indução de infecção experimental. (unesp.br)
  • Os efeitos de S. mutans sobre a candidose experimental em G. mellonella foram avaliados pela análise da curva de sobrevivência, pelo estudo da cultura da hemolinfa para quantificação de C. albicans e através da avaliação histológica da presença de hifas de C. albicans nos tecidos do hospedeiro. (unesp.br)