Mixture of antifungal heptaene macrolides from Streptomyces griseus or Actinomyces levoris used topically in candidiasis. The antibiotic complex is composed of candicidins A, B, C, and D, of which D is the major component.
An actinomycete from which the antibiotics STREPTOMYCIN, grisein, and CANDICIDIN are obtained.
Substances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues.
Hydrocarbons with more than one double bond. They are a reduced form of POLYYNES.
A heavy metal trace element with the atomic symbol Cu, atomic number 29, and atomic weight 63.55.
A sulfate salt of copper. It is a potent emetic and is used as an antidote for poisoning by phosphorus. It also can be used to prevent the growth of algae.
Productive or purposeful activities.
Ratio of output to effort, or the ratio of effort produced to energy expended.
People who take drugs for a non-therapeutic or non-medical effect. The drugs may be legal or illegal, but their use often results in adverse medical, legal, or social consequences for the users.
Assessment of physiological capacities in relation to job requirements. It is usually done by measuring certain physiological (e.g., circulatory and respiratory) variables during a gradually increasing workload until specific limitations occur with respect to those variables.

Rapamycin (AY-22,989), a new antifungal antibiotic. II. Fermentation, isolation and characterization. (1/28)

Rapamycin is a new antifungal antibiotic produced by Streptomyces hygroscopicus NRRL 5491. It was isolated from the mycelium by solvent extraction, purified by silica gel column chromatography and crystallized as a colorless solid which melts at 183 approximately to 185 degrees C and has the empirical formula C56H89NO14. From its characteristic ultraviolet absorption spectrum rapamycin can be classified as a triene. It is highly active against various Candida species, especially Candida albicans. Its activity is compared with that of amphotericin B, candicidin and nystatin.  (+info)

Isolation of mutants deregulated in phosphate control of candicidin biosynthesis. (2/28)

Mutants have been isolated in which phosphate does not inhibit the biosynthesis of candicidin. At high phosphate concentrations, candicidin production by phosphate-deregulated mutants is still inhibited, but to a lesser extent than in the wild type. Some of these mutants are higher candicidin producers than the wild type, not only in phosphate-supplemented medium but also in non-supplemented production medium. The high candicidin production by these mutants is due to (1) a high specific rate of candicidin biosynthesis and (2) an extended production phase. None of the phosphate-deregulated mutants in which uptake of [32P]phosphate was measured was a phosphate-permeability mutant.  (+info)

The candicidin gene cluster from Streptomyces griseus IMRU 3570. (3/28)

A 205 kb DNA region from Streptomyces griseus IMRU 3570, including the candicidin biosynthetic gene cluster, was cloned and partially sequenced. Analysis of the sequenced DNA led to identification of genes encoding part of a modular polyketide synthase (PKS), genes for thioesterase, macrolactone ring modification, mycosamine biosynthesis and attachment to the macrolide ring, candicidin export and regulatory proteins. It represents the first extensive genetic characterization of an aromatic polyene macrolide antibiotic biosynthetic gene cluster. Of particular interest is the presence of the CanP1 loading domain (the first described as responsible for the activation of an aromatic starter unit) and the polypeptide CanP3 (carrying modules for the formation of five out of seven conjugated double bonds). Disruption of the pabAB gene that encodes the starter unit of candicidin abolished its production [which was restored when exogenous p-aminobenzoic acid (PABA) was supplied to the culture] and resulted in an enhanced production of another antifungal compound that is barely detected in the wild-type.  (+info)

Solution NMR structure of five representative glycosylated polyene macrolide antibiotics with a sterol-dependent antifungal activity. (4/28)

Glycosylated polyene macrolide antibiotics, as nystatins and amphotericins, are amphiphilic structures known to exert antifungal activity by disrupting the fungal cell membrane, leading to leakage of cellular materials, and cell death. This membrane disruption is strongly influenced by the presence and the exact nature of the membrane sterols. The solution structures of five representative glycosylated members, three tetraenes (pimaricin, nystatin A1 and rimocidin) and two heptaenes (candidin and vacidin A) have been calculated using geometric restraints derived from 1H-NMR data and random searches of their conformational space. Despite a different apparent structural order, the NMR solutions structure indicate that the hydroxyl groups all clustered on one side of the rod-shaped structures, and the glycosyl moieties are structurally conserved both in their conformation and their apparent order. The molecular structures afford an understanding of their selective interaction with the membrane sterols and the design of new polyene macrolides with improved activities.  (+info)

Organizational and mutational analysis of a complete FR-008/candicidin gene cluster encoding a structurally related polyene complex. (5/28)

The complete gene cluster for biosynthesis of a polyene complex, FR-008, spans 137.2 kb of the genome of Streptomyces sp. FR-008 consisting of six genes for a modular PKS and 15 additional genes. The extensive similarity to the partially characterized candicidin gene cluster in Streptomyces griseus IMRU3570, especially for genes involved in mycosamine biosynthesis, prompted us to compare the compounds produced by Streptomyces sp. FR-008 and Streptomyces griseus IMRU3570, and we found that FR-008 and candicidin complex are identical. A model for biosynthesis of a set of four structurally related FR-008/candicidin compounds was proposed. Deletion of the putative regulatory genes abolished antibiotic production, while disruption of putative glycosyltransferase and GDP-ketosugar aminotransferase functionalities led to the productions of a set of nonmycosaminated aglycones and a novel polyene complex with attachment of altered sugar moiety, respectively.  (+info)

Incomplete beta-ketone processing as a mechanism for polyene structural variation in the FR-008/candicidin complex. (6/28)

 (+info)

Selective removal of aberrant extender units by a type II thioesterase for efficient FR-008/candicidin biosynthesis in Streptomyces sp. strain FR-008. (7/28)

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Tailoring the P450 monooxygenase gene for FR-008/candicidin biosynthesis. (8/28)

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Looking for online definition of candicidin in the Medical Dictionary? candicidin explanation free. What is candicidin? Meaning of candicidin medical term. What does candicidin mean?
Couchioplanes caeruleus DSM43634 synthesises 67-121C, an aromatic heptaene macrolide that contains a mannosyl-mycosaminyl disaccharide. An improved draft genome sequence was used to obtain the biosynthetic gene cluster for this antifungal. Bioinformatic analysis of the polyketide synthase indicated 2017 Hot Articles in Molecular Biosystems
The regulation of antibiotic biosynthesis by Streptomyces species is complex, especially for biosynthetic gene clusters with multiple regulatory genes. The biosynthetic gene cluster for the polyene antibiotic candicidin contains four consecutive regulatory genes, which encode regulatory proteins from different families and which form a subcluster within the larger biosynthetic gene cluster in Streptomyces sp. FR-008.... ...
Saccharomyces cerevisiae ATCC ® 9763™ Designation: NRRL Y-567 [CBS 2978, CBS 5900, CCY 21-4-48, CCY 21-4-54, NCTC 10716, NCTC 7239, NCYC 87, Pattee 6, PCI M-50] Application: Assay of amphotericin Assay of amphotericin B fungizone Assay of anisomycin Assay of antifongine Assay of candicidin Assay of natamycin pimaricin, tennecetin Assay of nystatin fungicidin Media testing Produces arginase Produces ethyl alcohol ethanol Food testing Pharmaceutical and Personal Care Produces histone deacetylase Produces nicotinic acid niacin Sterility testing Susceptibility testing Testing disinfectants Testing fungicides Produces ethanol from saccharified whole corn mash Reference strain for performance testing culture media listed by the ISO TC 34 SC 9 Joint Working Group 5 in the ISO 11133 and by the Working Party on Culture Media of the International Committee on Food Microbiology and Hygiene (ICFMH-WPCM)
Saccharomyces cerevisiae ATCC ® 9763™ Designation: NRRL Y-567 [CBS 2978, CBS 5900, CCY 21-4-48, CCY 21-4-54, NCTC 10716, NCTC 7239, NCYC 87, Pattee 6, PCI M-50] Application: Assay of amphotericin Assay of amphotericin B fungizone Assay of anisomycin Assay of antifongine Assay of candicidin Assay of natamycin pimaricin, tennecetin Assay of nystatin fungicidin Media testing Produces arginase Produces ethyl alcohol ethanol Food testing Pharmaceutical and Personal Care Produces histone deacetylase Produces nicotinic acid niacin Sterility testing Susceptibility testing Testing disinfectants Testing fungicides Produces ethanol from saccharified whole corn mash Reference strain for performance testing culture media listed by the ISO TC 34 SC 9 Joint Working Group 5 in the ISO 11133 and by the Working Party on Culture Media of the International Committee on Food Microbiology and Hygiene (ICFMH-WPCM)
ATC code G01 Gynecological antiinfectives and antiseptics is a therapeutic subgroup of the Anatomical Therapeutic Chemical Classification System, a system of alphanumeric codes developed by the WHO for the classification of drugs and other medical products. Subgroup G01 is part of the anatomical group G Genito-urinary system and sex hormones. Codes for veterinary use (ATCvet codes) can be created by placing the letter Q in front of the human ATC code: for example, QG01. ATCvet codes without corresponding human ATC codes are cited with the leading Q in the following list. National issues of the ATC classification may include additional codes not present in this list, which follows the WHO version. G01AA01 Nystatin G01AA02 Natamycin G01AA03 Amphotericin B G01AA04 Candicidin G01AA05 Chloramphenicol G01AA06 Hachimycin G01AA07 Oxytetracycline G01AA08 Carfecillin G01AA09 Mepartricin G01AA10 Clindamycin G01AA11 Pentamycin G01AA51 Nystatin, combinations QG01AA55 Choramphenicol, combinations QG01AA90 ...
We present a high-quality (|100× depth) Illumina genome sequence of the leaf-cutting ant Acromyrmex echinatior, a model species for symbiosis and reproductive conflict studies. We compare this genome with three previously sequenced genomes of ants from different subfamilies and focus our analyses …
Ortiz, Adriana, Ana Esperanza Franco-Molano & Mauricio Bacci Jr. A new species of Leucoagaricus (Agaricaceae) from Colombia. Mycotaxon 106: 371-378. 2008. ABSTRACT: A new taxon of Leucoagaricus is proposed as L. amazonicus. The collection representing this species was collected in the lowlands of the Amazonas Department, Colombia, on a dump produced by ants belonging to Acromyrmex octospinosus. The very particular habitat, the small size and dark brown basidiomata that stain yellowish when bruised, the peronate inferior annulus, and the cheilocystidia which are relatively short, capitate and filled with dense brown contents are some of the features of this species. KEYWORDS: Agaricales, taxonomy, Amazonia ...
Attine ants live in symbiosis with a basidiomycetous fungus that they rear on a substrate of plant material. This indirect herbivory implies that the symbiosis is likely to be nitrogen deprived, so that specific mechanisms may have evolved to enhance protein availability. We therefore hypothesized that fungal proteinase activity may have been under selection for efficiency and that different classes of proteinases might be involved. We determined proteinase activity profiles across a wide pH range for fungus gardens of 14 Panamanian species of fungus-growing ants, representing eight genera. We mapped these activity profiles on an independently obtained molecular phylogeny of the symbionts and show that total proteinase activity in lower attine symbionts peaks at ca. pH 6. The higher attine symbionts that have no known free-living relatives had much higher proteinase activities than the lower attine symbionts. Their total in vitro proteinase activity peaked at pH values around 5, which is close to the pH
Since being recognized as a new Panamanian species about 15 years ago, much has been learned about the biology of the leaf-cutting ant Acromyrmex echinatior, but the genetic basis of their farming lifestyle remained largely unknown. In this report, an international team of researchers has sequenced the genome of A. echinatior, and by comparison to other ant and insect genomes, identified genomic clues to the evolution of fungus farming behavior.. The authors noted that one of the most interesting findings in the genome of this leaf-cutting ant was that there are more genes in two particularly noteworthy gene families. Based on their function in other organisms, we expect them to be involved in mating system adaptations and symbiotic food processing with the fungus, said Dr. Sanne Nygaard of the Copenhagen Centre for Social Evolution, co-lead author of the study.. Nygaard explained that these findings are especially fascinating because known evolutionary changes in the reproductive biology and ...
The social Hymenoptera have distinct larval and adult stages separated by metamorphosis, which implies striking remodeling of external and internal body structures during the pupal stage. This imposes challenges to gut symbionts as existing cultures are lost and may or may not need to be replaced. To elucidate the extent to which metamorphosis interrupts associations between bacteria and hosts, we analysed changes in gut microbiota during development and traced the transmission routes of dominant symbionts from the egg to adult stage in the leaf-cutting ants Acromyrmex echinatior and Atta cephalotes, which are both important functional herbivores in the New World tropics. Bacterial density remained similar across the developmental stages of Acromyrmex, but Atta brood had very low bacterial prevalences suggesting that bacterial gut symbionts are not actively maintained. We found that Wolbachia was the absolute dominant bacterial species across developmental stages in Acromyrmex and we confirmed that Atta
But the story can get more complicated. Imagine a symbiosis with four co-evolving partners: three of them are engaged in a mutualistic relationship, while the fourth one is a parasite. Thats the beautiful case of fungus-growing ants. In their underground nests, the ants grow a mushroom-like fungus by feeding it with plant materials or other organic matter. In turn, the fungus serves as food for the ants (yes, this is agriculture!). But every garden has its pests, and the ants farm is home for the Escovopsis mold. Escovopsis is a specialized pest, found only on the crop of farming ants. To battle the parasite, the ants combine special behaviors and microbial symbionts. These insects carry a bunch of antibiotic-producing actinomycetes in elaborate cuticular crypts, supported by unique exocrine glands. The symbiotic bacteria produce substances that specifically inhibit Escovopsis growth. Although initially identified as Streptomyces, the actinomycete symbionts appear to belong to the ...
Brown DW, Cheung F, Proctor RH, Butchko RA, Zheng L, Lee Y, Utterback T, Smith S, Feldblyum T, Glenn AE, Plattner RD, Kendra DF, Town CD, Whitelaw CA ...
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Defense against biotic or abiotic stresses is one of the benefits of living in symbiosis. Leaf-cutting ants, which live in an obligate mutualism with a fungus, attenuate thermal and desiccation stress of their partner through behavioral responses, by choosing suitable places for fungus-rearing across the soil profile. The underground environment also presents hypoxic (low oxygen) and hypercapnic (high carbon dioxide) conditions, which can negatively influence the symbiont. Here, we investigated whether workers of the leaf-cutting ant Acromyrmex lundii use the CO\(_{2}\) concentration as an orientation cue when selecting a place to locate their fungus garden, and whether they show preferences for specific CO\(_{2}\) concentrations. We also evaluated whether levels preferred by workers for fungus-rearing differ from those selected for themselves. In the laboratory, CO\(_{2}\) preferences were assessed in binary choices between chambers with different CO\(_{2}\) concentrations, by quantifying ...
Description: The substance Filipin III is a polyene macrolide antibiotic and antifungal. It is from streptomyces filipinensis and has a purity of >98%. The pure substance is white or slightly yellow powder which is May be dissolved in methanol (10 mg/mL), ethanol (2 mg/mL) or DMSO (3 mg/mL ...
BIZARRIA JR, RODOLFO... Lack of fungal cultivar fidelity and low virulence of Escovopsis trichodermoides. Fungal Ecology 45 n. p. JUN 2020. Journal article.
[118 Pages Report] Check for Discount on Global P-Aminobenzoic Acid Market Research Report 2016 report by QYResearch Group. Notes: Production, means the output of P-Aminobenzoic Acid Revenue,...
The solubilization by lysophosphatidylcholine (LPC) of three n-alkyl esters of p-aminobenzoic acid has been studied. These esters have a local anaesthetic action. Quantitative studies show that the amount of compound solubilized is proportional to the LPC concentration and that solubilization increases in the order ethyl, n-propyl and n-butyl ester. 100MHz nmr studies indicate that the local anaesthetic esters are solubilized in the hydrocarbon interior of the LPC. ...
The present disclosure provides compositions and methods for the biosynthetic production of acetaminophen, p-aminophenol, and p-aminobenzoic acid and the purification of biologically derived acetaminophen.
Symbiont choice has been proposed to play an important role in shaping many symbiotic relationships, including the fungus-growing ant-microbe mutualism. Over millions of years, fungus-growing ants have defended their fungus gardens from specialized parasites with antibiotics produced by an actinomyc …
Leafcutter ants, signature denizens of New World tropical forests, are unique in their ability to harvest fresh leaves to cultivate a nutrient-rich fungus as food.. Now, this mutualism -- a complicated interplay of ants, fungi and a suite of bacteria -- is coming into sharper focus as a team of University of Wisconsin-Madison researchers has published the complete genome of the leafcutter ant, Atta cephalotes.. The study, published today (Feb. 10, 2011) in the journal Public Library of Science (PLoS) Genetics, by an international team led by UW-Madison bacteriology professors Cameron Currie and Garret Suen, illustrates how lifestyle can remake an animals genetic blueprint over the course of evolutionary history.. The genome, the first for a leafcutter ant, reveals that the insect has shed genes that other ant species use to help acquire nutrients. The leafcutter, which cannot survive without its fungus food, has apparently slimmed its genome to get rid of genes it no longer needs due to its ...
FR-900520 and FR-900523, novel neutral macrolide immunosuppressants, were isolated from the cultured broth of Streptomyces hygroscopicus subsp. yakushimaensis No. 7238. Their molecular formulae were determined as C43H69NO12 and C42H67NO12, respectively. The compounds suppressed immune response in vitro. IC50 values of FR-900520 and FR-900523 for mouse mixed lymphocyte reaction were 0.55 nM and 1.6 nM, respectively. FR-900520, the major component, clearly prolonged skin allograft survival in rats.
Streptomyces griseus EshA protein: developmentally regulated protein, required for sporogenic hyphal branches in Streptomyces griseus; amino acid sequence in first source
Biosynthetic Production of 4-Amino 4-Deoxychorismate (Adc) and [3R,4R]-4-Amino-3-Hydroxycyclohexa-1,5-Diene-1-Carboxylic Acid (3,4-Cha) - The invention relates to a process for the biosynthetic production of 4-amino-4-deoxychorismate (ADC) performed fermentatively in vivo with a 4-amino-4-deoxychorismate synthase, preferably a PabAB bipartite protein (which may be a fusion protein), at an increased level of activity, thereby obtaining a broth comprising ADC and 4-amino-4-deoxyprephenate (ADP), that are recovered. The invention also relates to a further process of converting the ADP into p-aminophenylalanine. The invention, moreover relates to biosynthetic production of [3R,4R]-4-amino-3-hydroxycyclohexa-1,5-diene-1-carboxylic acid (3,4-CHA), by concerted action of such 4-amino-4-deoxychorismate synthase and of an enzyme capable of converting isochorismate into [5S,6S]-5,6 dihydroxycyclohexa-1,3-diene-1-carboxylic acid (2,3-CHD), preferably a phenazine biosynthesis protein PhzD, including ...
Ten years ago, Cameron Currie, a microbial ecologist then at the University of Toronto in Ontario, Canada, discovered that leaf-cutting ants carry colonies of actinomycete bacteria on their bodies (C. R. Currie et al. Nature 398, 701-704; 1999). The bacteria churn out an antibiotic that protects the ants fungal crops from associated parasitic fungi (such as Escovopsis). On 29 March, Currie, Jon Clardy at the Harvard Medical School in Boston and their colleagues reported that they had isolated and purified one of these antifungals, which they named dentigerumycin, and that it is a chemical that has never been previously reported (D.-C. Oh et al. Nature Chem. Bio. doi: 10.1038/nchembio.159; 2009). The antifungal slowed the growth of a drug-resistant strain of the fungus Candida albicans, which causes yeast infections in people ...
The Species 2000/ITIS Catalogue of Life : 2006 Annual Checklist is a comprehensive index of all known plants, animals, fungi and micro-organisms. It can be used to search multiple databases simultaneously for the scientific name of an organism.
ID C6WDR1_ACTMD Unreviewed; 187 AA. AC C6WDR1; DT 22-SEP-2009, integrated into UniProtKB/TrEMBL. DT 22-SEP-2009, sequence version 1. DT 07-JUN-2017, entry version 53. DE RecName: Full=Ferritin {ECO:0000256,RuleBase:RU361145}; DE EC=1.16.3.2 {ECO:0000256,RuleBase:RU361145}; GN OrderedLocusNames=Amir_0082 {ECO:0000313,EMBL:ACU34056.1}; OS Actinosynnema mirum (strain ATCC 29888 / DSM 43827 / NBRC 14064 / IMRU OS 3971). OC Bacteria; Actinobacteria; Pseudonocardiales; Pseudonocardiaceae; OC Actinosynnema. OX NCBI_TaxID=446462 {ECO:0000313,EMBL:ACU34056.1, ECO:0000313,Proteomes:UP000002213}; RN [1] {ECO:0000313,EMBL:ACU34056.1, ECO:0000313,Proteomes:UP000002213} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC 29888 / DSM 43827 / NBRC 14064 / IMRU 3971 RC {ECO:0000313,Proteomes:UP000002213}; RX PubMed=21304636; DOI=10.4056/sigs.21137; RA Land M., Lapidus A., Mayilraj S., Chen F., Copeland A., Del Rio T.G., RA Nolan M., Lucas S., Tice H., Cheng J.F., Chertkov O., Bruce D., RA Goodwin ...
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Fr-009 found in: Ceramic Orange Seal ABEC 7 Manufacturer/Model By Series, Ceramic Lightning ABEC 5 Manufacturer/Model By Series, ABU GARCIA 4600C3 ..
TY - JOUR. T1 - Targeting intracellular p-aminobenzoic acid production potentiates the anti-tubercular action of antifolates. AU - Thiede, Joshua M.. AU - Kordus, Shannon Lynn. AU - Turman, Breanna J.. AU - Buonomo, Joseph A.. AU - Aldrich, Courtney C. AU - Minato, Yusuke. AU - Baughn, Anthony D. N1 - Funding Information: We thank Luke Erber for assistance in identification and initial characterization of the pabC mutant strain. This work was supported by a grant from the University of Minnesota Academic Health Center Faculty Research Development Program to A.D.B. and C.C.A., and by startup funds from the University of Minnesota to A.D.B.. PY - 2016. Y1 - 2016. N2 - 1 The ability to revitalize and re-purpose existing drugs offers a powerful approach for novel treatment options against Mycobacterium tuberculosis and other infectious agents. Antifolates are an underutilized drug class in tuberculosis (TB) therapy, capable of disrupting the biosynthesis of tetrahydrofolate, an essential cellular ...
Detail záznamu - tmRNA of Streptomyces collinus and Streptomyces griseus during the growth and in the presence of antibiotics - Detail záznamu - Knihovna Akademie věd České republiky
This bioactive compound was named candicidin, because of its high activity on Candida albicans. "Product information Candicidin ... Candicidin is an antifungal compound obtained from Streptomyces griseus. It is active against some fungi including Candida ... Waksman SA, Lechevalier HA, Schaffner CP (1965). "Candicidin and other polyenic antifungal antibiotics". Bulletin of the World ... Candicidin is administered intravaginally in the treatment of vulvovaginal candidiasis. ...
Haeder, Susanne; Wirth, Rainer; Herz, Hubert; Spiteller, Dieter (2009-03-24). "Candicidin-producing Streptomyces support leaf- ...
The following polyenes are used as antibiotics for humans: amphotericin B, nystatin, candicidin, pimaricin, methyl partricin, ...
... candicidin, candidin. Waksman took credit for Albert Schatz's discovery of streptomycin, the first effective drug against gram ...
... candicidin, candidin, and others. Waksman, along with graduate student Albert Schatz (1920-2005), discovered streptomycin-a ...
G01AA01 Nystatin G01AA02 Natamycin G01AA03 Amphotericin B G01AA04 Candicidin G01AA05 Chloramphenicol G01AA06 Hachimycin G01AA07 ...
... candicidin MeSH D09.408.477.250 - erythromycin MeSH D09.408.477.250.050 - azithromycin MeSH D09.408.477.250.100 - ...
... candicidin MeSH D02.540.505.187 - epothilones MeSH D02.540.505.250 - erythromycin MeSH D02.540.505.250.050 - azithromycin MeSH ...
Amphotericin B Candicidin Filipin - 35 carbons, binds to cholesterol (toxic) Hamycin Natamycin - 33 carbons, binds well to ...
... candicidin, and candidin. Of these, streptomycin and neomycin found extensive application in the treatment of numerous ...
Candex candicidin (INN) Candin Candistatin candocuronium iodide (INN) candoxatril (INN) candoxatrilat (INN) canertinib (USAN) ...
... candicidin MeSH D04.345.349.156 - cytochalasins MeSH D04.345.349.156.370 - cytochalasin b MeSH D04.345.349.156.450 - ...
Dive into the research topics of Coordinate regulation of antimycin and candicidin biosynthesis. Together they form a unique ...
Production of the antibiotic FR-008/candicidin in Streptomyces sp. FR-008 is co-regulated by two regulators, FscRI and FscRIV, ... FR-008, the biosynthetic gene cluster of the polyene antibiotic FR-008, also known as candicidin, consists of 21 genes, ...
Candicidin. Used in the topical treatment of vulvovaginal candidiasis.. Clarithromycin. A macrolide antibiotic used for the ...
Haeder, S.; Wirth, R.; Herz, H.; Spiteller, D.: Candicidin-producing Streptomyces support leaf-cutting ants to protect their ...
Candicidin D2.540.505.125 D2.540.576.500.968 Candy G7.203.300.140 Capripoxvirus B4.909.204.783.160.150 Capsicum J2.500.850.175 ...
Candicidin (USP grade powder). 200 mg Variant price modifier: Base price with tax: ...
candicidin metabolic process + carbohydrate derivative metabolic process + carbohydrate metabolic process + carbon fixation + ...
Candicidin - Preferred Concept UI. M0003252. Scope note. Mixture of antifungal heptaene macrolides from Streptomyces griseus or ... use CANDICIDIN to search LEVORIN 1978-89. History Note:. 91(75); was see under ANTIBIOTICS, MACROLIDE 1990; was see under ...
Candicidin (substance). Code System Preferred Concept Name. Candicidin (substance). Concept Status. Published. ...
candicidin biosynthesis. 4-Aminobenzoic_acid + O2 + reduced_acceptor <=> 4-hydroxyylaminobenzoate + H2O + acceptor not assigned ...
D02.540.576.500.968 Candicidin .. D02.886 Sulfur Compounds .. D02.886.675 Thiazoles .. D02.886.675.346 Levamisole .. D02.886. ...
A knowledge graph of biological entities such as genes, gene functions, diseases, phenotypes and chemicals. Embeddings are generated with Walking RDF and OWL method ...
A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation of cytokines thereby inhibiting cytokine production. It is bioactive only when bound to IMMUNOPHILINS. Sirolimus is a potent immunosuppressant and possesses both antifungal and antineoplastic properties ...
In a double-blind study, candicidin therapy resulted in over-all clinical improvement of benign prostatic hypertrophy symptoms ... Histologic review of prostates of candicidin-treated patients showed more stroma relative to the epithelium. The epithelium was ... and corticosteroid levels ramained within normal values with candicidin therapy. ...
Haeder S, Wirth R, Herz H, Spiteller D: Candicidin-producing Streptomyces support leaf-cutting ants to protect their fungus ...
polyene antimycotic (Nystatin, Natamycin, Amphotericin B) - Candicidin - Chloramphenicol - Hachimycin - Oxytetracycline - ...
or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites. ...
Candicidin D2.540.505.125 D2.540.576.500.968 Candy G7.203.300.140 Capripoxvirus B4.909.204.783.160.150 Capsicum J2.500.850.175 ...
C14.907.253.329.249 Candicidin D4.345.349.125 D9.408.477.125 Carboplatin D1.632.800.338 Carcinoma, Merkel Cell C2.256.721.150 ...
Candicidin D2.540.505.125 D2.540.576.500.968 Candy G7.203.300.140 Capripoxvirus B4.909.204.783.160.150 Capsicum J2.500.850.175 ...
C14.907.253.329.249 Candicidin D4.345.349.125 D9.408.477.125 Carboplatin D1.632.800.338 Carcinoma, Merkel Cell C2.256.721.150 ...
Candicidin D2.540.505.125 D2.540.576.500.968 Candy G7.203.300.140 Capripoxvirus B4.909.204.783.160.150 Capsicum J2.500.850.175 ...
C14.907.253.329.249 Candicidin D4.345.349.125 D9.408.477.125 Carboplatin D1.632.800.338 Carcinoma, Merkel Cell C2.256.721.150 ...
C14.907.253.329.249 Candicidin D4.345.349.125 D9.408.477.125 Carboplatin D1.632.800.338 Carcinoma, Merkel Cell C2.256.721.150 ...
C14.907.253.329.249 Candicidin D4.345.349.125 D9.408.477.125 Carboplatin D1.632.800.338 Carcinoma, Merkel Cell C2.256.721.150 ...
C14.907.253.329.249 Candicidin D4.345.349.125 D9.408.477.125 Carboplatin D1.632.800.338 Carcinoma, Merkel Cell C2.256.721.150 ...
  • Candicidin-producing Streptomyces support leaf-cutting ants to protect their fungus garden against the pathogenic fungus Escovopsis. (mpg.de)
  • Mezcla de macrólidos heptenos antifúngicos obtenidos a partir de Streptomyces griseus o Actinomyces levoris utilizada tópicamente en la candidiasis. (bvsalud.org)
  • Shibata M, Honjo M, Tokui Y, Nakazawa N. On a new antifungal and antiyeast substance, candicidin produced by a streptomyces. (dsmz.de)