Candicidin
Streptomyces griseus
Antifungal Agents
Copper
Copper Sulfate
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Rapamycin (AY-22,989), a new antifungal antibiotic. II. Fermentation, isolation and characterization. (1/28)
Rapamycin is a new antifungal antibiotic produced by Streptomyces hygroscopicus NRRL 5491. It was isolated from the mycelium by solvent extraction, purified by silica gel column chromatography and crystallized as a colorless solid which melts at 183 approximately to 185 degrees C and has the empirical formula C56H89NO14. From its characteristic ultraviolet absorption spectrum rapamycin can be classified as a triene. It is highly active against various Candida species, especially Candida albicans. Its activity is compared with that of amphotericin B, candicidin and nystatin. (+info)Isolation of mutants deregulated in phosphate control of candicidin biosynthesis. (2/28)
Mutants have been isolated in which phosphate does not inhibit the biosynthesis of candicidin. At high phosphate concentrations, candicidin production by phosphate-deregulated mutants is still inhibited, but to a lesser extent than in the wild type. Some of these mutants are higher candicidin producers than the wild type, not only in phosphate-supplemented medium but also in non-supplemented production medium. The high candicidin production by these mutants is due to (1) a high specific rate of candicidin biosynthesis and (2) an extended production phase. None of the phosphate-deregulated mutants in which uptake of [32P]phosphate was measured was a phosphate-permeability mutant. (+info)The candicidin gene cluster from Streptomyces griseus IMRU 3570. (3/28)
A 205 kb DNA region from Streptomyces griseus IMRU 3570, including the candicidin biosynthetic gene cluster, was cloned and partially sequenced. Analysis of the sequenced DNA led to identification of genes encoding part of a modular polyketide synthase (PKS), genes for thioesterase, macrolactone ring modification, mycosamine biosynthesis and attachment to the macrolide ring, candicidin export and regulatory proteins. It represents the first extensive genetic characterization of an aromatic polyene macrolide antibiotic biosynthetic gene cluster. Of particular interest is the presence of the CanP1 loading domain (the first described as responsible for the activation of an aromatic starter unit) and the polypeptide CanP3 (carrying modules for the formation of five out of seven conjugated double bonds). Disruption of the pabAB gene that encodes the starter unit of candicidin abolished its production [which was restored when exogenous p-aminobenzoic acid (PABA) was supplied to the culture] and resulted in an enhanced production of another antifungal compound that is barely detected in the wild-type. (+info)Solution NMR structure of five representative glycosylated polyene macrolide antibiotics with a sterol-dependent antifungal activity. (4/28)
Glycosylated polyene macrolide antibiotics, as nystatins and amphotericins, are amphiphilic structures known to exert antifungal activity by disrupting the fungal cell membrane, leading to leakage of cellular materials, and cell death. This membrane disruption is strongly influenced by the presence and the exact nature of the membrane sterols. The solution structures of five representative glycosylated members, three tetraenes (pimaricin, nystatin A1 and rimocidin) and two heptaenes (candidin and vacidin A) have been calculated using geometric restraints derived from 1H-NMR data and random searches of their conformational space. Despite a different apparent structural order, the NMR solutions structure indicate that the hydroxyl groups all clustered on one side of the rod-shaped structures, and the glycosyl moieties are structurally conserved both in their conformation and their apparent order. The molecular structures afford an understanding of their selective interaction with the membrane sterols and the design of new polyene macrolides with improved activities. (+info)Organizational and mutational analysis of a complete FR-008/candicidin gene cluster encoding a structurally related polyene complex. (5/28)
The complete gene cluster for biosynthesis of a polyene complex, FR-008, spans 137.2 kb of the genome of Streptomyces sp. FR-008 consisting of six genes for a modular PKS and 15 additional genes. The extensive similarity to the partially characterized candicidin gene cluster in Streptomyces griseus IMRU3570, especially for genes involved in mycosamine biosynthesis, prompted us to compare the compounds produced by Streptomyces sp. FR-008 and Streptomyces griseus IMRU3570, and we found that FR-008 and candicidin complex are identical. A model for biosynthesis of a set of four structurally related FR-008/candicidin compounds was proposed. Deletion of the putative regulatory genes abolished antibiotic production, while disruption of putative glycosyltransferase and GDP-ketosugar aminotransferase functionalities led to the productions of a set of nonmycosaminated aglycones and a novel polyene complex with attachment of altered sugar moiety, respectively. (+info)Incomplete beta-ketone processing as a mechanism for polyene structural variation in the FR-008/candicidin complex. (6/28)
(+info)Selective removal of aberrant extender units by a type II thioesterase for efficient FR-008/candicidin biosynthesis in Streptomyces sp. strain FR-008. (7/28)
(+info)Tailoring the P450 monooxygenase gene for FR-008/candicidin biosynthesis. (8/28)
(+info)
Candicidin | definition of candicidin by Medical dictionary
New insights into polyene macrolide biosynthesis in Couchioplanes caeruleus - Molecular BioSystems (RSC Publishing)
antibiotic | Applied and Environmental Microbiology
Saccharomyces cerevisiae Meyen ex E.C. Hansen ATCC ® 9763™
Saccharomyces cerevisiae Meyen ex E.C. Hansen ATCC ® 9763™
ATC code G01 - Wikipedia
The genome of the leaf-cutting ant Acromyrmex echinatior suggests key adaptations to advanced social life and fungus farming
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Evolutionary patterns of proteinase activity in attine ant fungus gardens | BMC Microbiology | Full Text
CSHLPress.com
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Frontiers | Diversity and Transmission of Gut Bacteria in Atta and Acromyrmex Leaf-Cutting Ants during Development |...
Intertwined lives: symbiosis
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FR-900520 and FR-900523, novel immunosuppressants isolated from a Streptomyces. II. Fermentation, isolation and physico...
Streptomyces griseus EshA protein
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Fr-009 at Boca Bearings
Targeting intracellular p-aminobenzoic acid production potentiates the anti-tubercular action of antifolates<...
tmRNA of Streptomyces collinus and Streptomyces griseus during the gr…
Candicidin
This bioactive compound was named candicidin, because of its high activity on Candida albicans. "Product information Candicidin ... Candicidin is an antifungal compound obtained from Streptomyces griseus. It is active against some fungi including Candida ... Waksman SA, Lechevalier HA, Schaffner CP (1965). "Candicidin and other polyenic antifungal antibiotics". Bulletin of the World ... Candicidin is administered intravaginally in the treatment of vulvovaginal candidiasis. ...
Fungus-growing ants
Haeder, Susanne; Wirth, Rainer; Herz, Hubert; Spiteller, Dieter (2009-03-24). "Candicidin-producing Streptomyces support leaf- ...
Polyene
The following polyenes are used as antibiotics for humans: amphotericin B, nystatin, candicidin, pimaricin, methyl partricin, ...
Selman Waksman
... candicidin, candidin. Waksman took credit for Albert Schatz's discovery of streptomycin, the first effective drug against gram ...
Rutgers University
... candicidin, candidin, and others. Waksman, along with graduate student Albert Schatz (1920-2005), discovered streptomycin-a ...
ATC code G01
G01AA01 Nystatin G01AA02 Natamycin G01AA03 Amphotericin B G01AA04 Candicidin G01AA05 Chloramphenicol G01AA06 Hachimycin G01AA07 ...
List of MeSH codes (D09)
... candicidin MeSH D09.408.477.250 - erythromycin MeSH D09.408.477.250.050 - azithromycin MeSH D09.408.477.250.100 - ...
List of MeSH codes (D02)
... candicidin MeSH D02.540.505.187 - epothilones MeSH D02.540.505.250 - erythromycin MeSH D02.540.505.250.050 - azithromycin MeSH ...
Antifungal
Amphotericin B Candicidin Filipin - 35 carbons, binds to cholesterol (toxic) Hamycin Natamycin - 33 carbons, binds well to ...
Streptomycin
... candicidin, and candidin. Of these, streptomycin and neomycin found extensive application in the treatment of numerous ...
List of drugs: C-Ca
Candex candicidin (INN) Candin Candistatin candocuronium iodide (INN) candoxatril (INN) candoxatrilat (INN) canertinib (USAN) ...
List of MeSH codes (D04)
... candicidin MeSH D04.345.349.156 - cytochalasins MeSH D04.345.349.156.370 - cytochalasin b MeSH D04.345.349.156.450 - ...
Coordinate regulation of antimycin and candicidin biosynthesis - Fingerprint
- University of Strathclyde
Volume 161, Issue 3 | Microbiology Society
Polyketides | DrugBank Online
Home | Max Planck Institute for Chemical Ecology
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Chemical Reference
olefinic compound metabolic process - Ontology Browser - Rat Genome Database
DeCS
Code System Concept
MMTB
DeCS Ingl s
Bio2Vec
Sirolimus | Harvard Catalyst Profiles | Harvard Catalyst
A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation of cytokines thereby inhibiting cytokine production. It is bioactive only when bound to IMMUNOPHILINS. Sirolimus is a potent immunosuppressant and possesses both antifungal and antineoplastic properties ...
Pesquisa | Biblioteca Virtual em Saúde - BRASIL
In a double-blind study, candicidin therapy resulted in over-all clinical improvement of benign prostatic hypertrophy symptoms ... Histologic review of prostates of candicidin-treated patients showed more stroma relative to the epithelium. The epithelium was ... and corticosteroid levels ramained within normal values with candicidin therapy. ...
Genome degeneration affects both extracellular and intracellular bacterial endosymbionts | Journal of Biology | Full Text
Endodontic Devices Market Size, Share & Trends Analysis Report and Segment Forecast, 2026 Grand View Research, Inc - PDF Free...
Copper usnate - wikidoc
macrolides | NAL Agricultural Thesaurus
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MESH TREE NUMBER CHANGES - 2012 MeSH. August 19, 2011
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MESH TREE NUMBER CHANGES - 2012 MeSH. August 19, 2011
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MESH TREE NUMBER CHANGES - 2012 MeSH. August 19, 2011
MESH TREE NUMBER CHANGES - 2012 MeSH. August 19, 2011
MESH TREE NUMBER CHANGES - 2012 MeSH. August 19, 2011
MESH TREE NUMBER CHANGES - 2012 MeSH. August 19, 2011
Streptomyces2
- Candicidin-producing Streptomyces support leaf-cutting ants to protect their fungus garden against the pathogenic fungus Escovopsis. (mpg.de)
- Mezcla de macrólidos heptenos antifúngicos obtenidos a partir de Streptomyces griseus o Actinomyces levoris utilizada tópicamente en la candidiasis. (bvsalud.org)
ANTIFUNGAL1
- Shibata M, Honjo M, Tokui Y, Nakazawa N. On a new antifungal and antiyeast substance, candicidin produced by a streptomyces. (dsmz.de)