Candicidin: Mixture of antifungal heptaene macrolides from Streptomyces griseus or Actinomyces levoris used topically in candidiasis. The antibiotic complex is composed of candicidins A, B, C, and D, of which D is the major component.Streptomyces griseus: An actinomycete from which the antibiotics STREPTOMYCIN, grisein, and CANDICIDIN are obtained.Antifungal Agents: Substances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues.Polyenes: Hydrocarbons with more than one double bond. They are a reduced form of POLYYNES.Natamycin: Amphoteric macrolide antifungal antibiotic from Streptomyces natalensis or S. chattanoogensis. It is used for a variety of fungal infections, mainly topically.Saccharomyces cerevisiae: A species of the genus SACCHAROMYCES, family Saccharomycetaceae, order Saccharomycetales, known as "baker's" or "brewer's" yeast. The dried form is used as a dietary supplement.Terminology as Topic: The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.Food Microbiology: The presence of bacteria, viruses, and fungi in food and food products. This term is not restricted to pathogenic organisms: the presence of various non-pathogenic bacteria and fungi in cheeses and wines, for example, is included in this concept.Amphotericin B: Macrolide antifungal antibiotic produced by Streptomyces nodosus obtained from soil of the Orinoco river region of Venezuela.Saccharomyces cerevisiae Proteins: Proteins obtained from the species SACCHAROMYCES CEREVISIAE. The function of specific proteins from this organism are the subject of intense scientific interest and have been used to derive basic understanding of the functioning similar proteins in higher eukaryotes.PubMed: A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.BooksPublishing: "The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.MEDLINE: The premier bibliographic database of the NATIONAL LIBRARY OF MEDICINE. MEDLINE® (MEDLARS Online) is the primary subset of PUBMED and can be searched on NLM's Web site in PubMed or the NLM Gateway. MEDLINE references are indexed with MEDICAL SUBJECT HEADINGS (MeSH).Serial Publications: Publications in any medium issued in successive parts bearing numerical or chronological designations and intended to be continued indefinitely. (ALA Glossary of Library and Information Science, 1983, p203)Biological Science Disciplines: All of the divisions of the natural sciences dealing with the various aspects of the phenomena of life and vital processes. The concept includes anatomy and physiology, biochemistry and biophysics, and the biology of animals, plants, and microorganisms. It should be differentiated from BIOLOGY, one of its subdivisions, concerned specifically with the origin and life processes of living organisms.Peripheral Nervous System Diseases: Diseases of the peripheral nerves external to the brain and spinal cord, which includes diseases of the nerve roots, ganglia, plexi, autonomic nerves, sensory nerves, and motor nerves.Databases, Chemical: Databases devoted to knowledge about specific chemicals.Databases, Pharmaceutical: Databases devoted to knowledge about PHARMACEUTICAL PRODUCTS.Piperidines: A family of hexahydropyridines.Angina Pectoris: The symptom of paroxysmal pain consequent to MYOCARDIAL ISCHEMIA usually of distinctive character, location and radiation. It is thought to be provoked by a transient stressful situation during which the oxygen requirements of the MYOCARDIUM exceed that supplied by the CORONARY CIRCULATION.Pharmacological Processes: The metabolism of drugs and their mechanisms of action.Coronary Vessels: The veins and arteries of the HEART.Oxalobacteraceae: A family of gram-negative bacteria in the class BETAPROTEOBACTERIA. There are at least eight genera.Chromobacterium: A genus of gram-negative, facultatively anaerobic, rod-shaped bacteria occurring in soil and water. Its organisms are generally nonpathogenic, but some species do cause infections of mammals, including humans.Ochromonas: A genus of GOLDEN-BROWN ALGAE in the family Ochromonadaceae, found mostly in freshwater. They bear two unequal FLAGELLA and are heterotrophic.Micrococcus luteus: A species of gram-positive, spherical bacteria whose organisms occur in tetrads and in irregular clusters of tetrads. The primary habitat is mammalian skin.Dysidea: A genus of SPONGES in the family Dysideidae, in which all skeletal fibers are filled with detritus.Biological Products: Complex pharmaceutical substances, preparations, or matter derived from organisms usually obtained by biological methods or assay.Gene Transfer, Horizontal: The naturally occurring transmission of genetic information between organisms, related or unrelated, circumventing parent-to-offspring transmission. Horizontal gene transfer may occur via a variety of naturally occurring processes such as GENETIC CONJUGATION; GENETIC TRANSDUCTION; and TRANSFECTION. It may result in a change of the recipient organism's genetic composition (TRANSFORMATION, GENETIC).alpha-Macroglobulins: Glycoproteins with a molecular weight of approximately 620,000 to 680,000. Precipitation by electrophoresis is in the alpha region. They include alpha 1-macroglobulins and alpha 2-macroglobulins. These proteins exhibit trypsin-, chymotrypsin-, thrombin-, and plasmin-binding activity and function as hormonal transporters.Patents as Topic: Exclusive legal rights or privileges applied to inventions, plants, etc.Inventions: A novel composition, device, or process, independently conceived de novo or derived from a pre-existing model.Intellectual Property: Property, such as patents, trademarks, and copyright, that results from creative effort. The Patent and Copyright Clause (Art. 1, Sec. 8, cl. 8) of the United States Constitution provides for promoting the progress of science and useful arts by securing for limited times to authors and inventors, the exclusive right to their respective writings and discoveries. (From Black's Law Dictionary, 5th ed, p1014)History, 18th Century: Time period from 1701 through 1800 of the common era.Biotechnology: Body of knowledge related to the use of organisms, cells or cell-derived constituents for the purpose of developing products which are technically, scientifically and clinically useful. Alteration of biologic function at the molecular level (i.e., GENETIC ENGINEERING) is a central focus; laboratory methods used include TRANSFECTION and CLONING technologies, sequence and structure analysis algorithms, computer databases, and gene and protein structure function analysis and prediction.History, 17th Century: Time period from 1601 through 1700 of the common era.Insulin, Long-Acting: Insulin formulations that contain substances that retard absorption thus extending the time period of action.Insulin, Isophane: An intermediate-acting INSULIN preparation with onset time of 2 hours and duration of 24 hours. It is produced by crystallizing ZINC-insulin-PROTAMINES at neutral pH 7. Thus it is called neutral protamine Hagedorn for inventor Hans Christian Hagedorn.Hypoglycemic Agents: Substances which lower blood glucose levels.Insulin: A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1).Injections, Jet: The injection of solutions into the skin by compressed air devices so that only the solution pierces the skin.Disposable Equipment: Apparatus, devices, or supplies intended for one-time or temporary use.Physical Processes: The forces and principles of action of matter and energy.Ointments: Semisolid preparations used topically for protective emollient effects or as a vehicle for local administration of medications. Ointment bases are various mixtures of fats, waxes, animal and plant oils and solid and liquid hydrocarbons.Pemphigoid, Benign Mucous Membrane: A chronic blistering disease with predilection for mucous membranes and less frequently the skin, and with a tendency to scarring. It is sometimes called ocular pemphigoid because of conjunctival mucous membrane involvement.Mucous Membrane: An EPITHELIUM with MUCUS-secreting cells, such as GOBLET CELLS. It forms the lining of many body cavities, such as the DIGESTIVE TRACT, the RESPIRATORY TRACT, and the reproductive tract. Mucosa, rich in blood and lymph vessels, comprises an inner epithelium, a middle layer (lamina propria) of loose CONNECTIVE TISSUE, and an outer layer (muscularis mucosae) of SMOOTH MUSCLE CELLS that separates the mucosa from submucosa.Ointment Bases: Various mixtures of fats, waxes, animal and plant oils and solid and liquid hydrocarbons; vehicles for medicinal substances intended for external application; there are four classes: hydrocarbon base, absorption base, water-removable base and water-soluble base; several are also emollients.Petrolatum: A colloidal system of semisolid hydrocarbons obtained from PETROLEUM. It is used as an ointment base, topical protectant, and lubricant.Skin: The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.Administration, Topical: The application of drug preparations to the surfaces of the body, especially the skin (ADMINISTRATION, CUTANEOUS) or mucous membranes. This method of treatment is used to avoid systemic side effects when high doses are required at a localized area or as an alternative systemic administration route, to avoid hepatic processing for example.

Rapamycin (AY-22,989), a new antifungal antibiotic. II. Fermentation, isolation and characterization. (1/28)

Rapamycin is a new antifungal antibiotic produced by Streptomyces hygroscopicus NRRL 5491. It was isolated from the mycelium by solvent extraction, purified by silica gel column chromatography and crystallized as a colorless solid which melts at 183 approximately to 185 degrees C and has the empirical formula C56H89NO14. From its characteristic ultraviolet absorption spectrum rapamycin can be classified as a triene. It is highly active against various Candida species, especially Candida albicans. Its activity is compared with that of amphotericin B, candicidin and nystatin.  (+info)

Isolation of mutants deregulated in phosphate control of candicidin biosynthesis. (2/28)

Mutants have been isolated in which phosphate does not inhibit the biosynthesis of candicidin. At high phosphate concentrations, candicidin production by phosphate-deregulated mutants is still inhibited, but to a lesser extent than in the wild type. Some of these mutants are higher candicidin producers than the wild type, not only in phosphate-supplemented medium but also in non-supplemented production medium. The high candicidin production by these mutants is due to (1) a high specific rate of candicidin biosynthesis and (2) an extended production phase. None of the phosphate-deregulated mutants in which uptake of [32P]phosphate was measured was a phosphate-permeability mutant.  (+info)

The candicidin gene cluster from Streptomyces griseus IMRU 3570. (3/28)

A 205 kb DNA region from Streptomyces griseus IMRU 3570, including the candicidin biosynthetic gene cluster, was cloned and partially sequenced. Analysis of the sequenced DNA led to identification of genes encoding part of a modular polyketide synthase (PKS), genes for thioesterase, macrolactone ring modification, mycosamine biosynthesis and attachment to the macrolide ring, candicidin export and regulatory proteins. It represents the first extensive genetic characterization of an aromatic polyene macrolide antibiotic biosynthetic gene cluster. Of particular interest is the presence of the CanP1 loading domain (the first described as responsible for the activation of an aromatic starter unit) and the polypeptide CanP3 (carrying modules for the formation of five out of seven conjugated double bonds). Disruption of the pabAB gene that encodes the starter unit of candicidin abolished its production [which was restored when exogenous p-aminobenzoic acid (PABA) was supplied to the culture] and resulted in an enhanced production of another antifungal compound that is barely detected in the wild-type.  (+info)

Solution NMR structure of five representative glycosylated polyene macrolide antibiotics with a sterol-dependent antifungal activity. (4/28)

Glycosylated polyene macrolide antibiotics, as nystatins and amphotericins, are amphiphilic structures known to exert antifungal activity by disrupting the fungal cell membrane, leading to leakage of cellular materials, and cell death. This membrane disruption is strongly influenced by the presence and the exact nature of the membrane sterols. The solution structures of five representative glycosylated members, three tetraenes (pimaricin, nystatin A1 and rimocidin) and two heptaenes (candidin and vacidin A) have been calculated using geometric restraints derived from 1H-NMR data and random searches of their conformational space. Despite a different apparent structural order, the NMR solutions structure indicate that the hydroxyl groups all clustered on one side of the rod-shaped structures, and the glycosyl moieties are structurally conserved both in their conformation and their apparent order. The molecular structures afford an understanding of their selective interaction with the membrane sterols and the design of new polyene macrolides with improved activities.  (+info)

Organizational and mutational analysis of a complete FR-008/candicidin gene cluster encoding a structurally related polyene complex. (5/28)

The complete gene cluster for biosynthesis of a polyene complex, FR-008, spans 137.2 kb of the genome of Streptomyces sp. FR-008 consisting of six genes for a modular PKS and 15 additional genes. The extensive similarity to the partially characterized candicidin gene cluster in Streptomyces griseus IMRU3570, especially for genes involved in mycosamine biosynthesis, prompted us to compare the compounds produced by Streptomyces sp. FR-008 and Streptomyces griseus IMRU3570, and we found that FR-008 and candicidin complex are identical. A model for biosynthesis of a set of four structurally related FR-008/candicidin compounds was proposed. Deletion of the putative regulatory genes abolished antibiotic production, while disruption of putative glycosyltransferase and GDP-ketosugar aminotransferase functionalities led to the productions of a set of nonmycosaminated aglycones and a novel polyene complex with attachment of altered sugar moiety, respectively.  (+info)

Incomplete beta-ketone processing as a mechanism for polyene structural variation in the FR-008/candicidin complex. (6/28)

 (+info)

Selective removal of aberrant extender units by a type II thioesterase for efficient FR-008/candicidin biosynthesis in Streptomyces sp. strain FR-008. (7/28)

 (+info)

Tailoring the P450 monooxygenase gene for FR-008/candicidin biosynthesis. (8/28)

 (+info)

Couchioplanes caeruleus DSM43634 synthesises 67-121C, an aromatic heptaene macrolide that contains a mannosyl-mycosaminyl disaccharide. An improved draft genome sequence was used to obtain the biosynthetic gene cluster for this antifungal. Bioinformatic analysis of the polyketide synthase indicated 2017 Hot Articles in Molecular Biosystems
The regulation of antibiotic biosynthesis by Streptomyces species is complex, especially for biosynthetic gene clusters with multiple regulatory genes. The biosynthetic gene cluster for the polyene antibiotic candicidin contains four consecutive regulatory genes, which encode regulatory proteins from different families and which form a subcluster within the larger biosynthetic gene cluster in Streptomyces sp. FR-008.... ...
Saccharomyces cerevisiae ATCC ® 9763™ Designation: NRRL Y-567 [CBS 2978, CBS 5900, CCY 21-4-48, CCY 21-4-54, NCTC 10716, NCTC 7239, NCYC 87, Pattee 6, PCI M-50] Application: Assay of amphotericin Assay of amphotericin B fungizone Assay of anisomycin Assay of antifongine Assay of candicidin Assay of natamycin pimaricin, tennecetin Assay of nystatin fungicidin Media testing Produces arginase Produces ethyl alcohol ethanol Food testing Pharmaceutical and Personal Care Produces histone deacetylase Produces nicotinic acid niacin Sterility testing Susceptibility testing Testing disinfectants Testing fungicides Produces ethanol from saccharified whole corn mash Reference strain for performance testing culture media listed by the ISO TC 34 SC 9 Joint Working Group 5 in the ISO 11133 and by the Working Party on Culture Media of the International Committee on Food Microbiology and Hygiene (ICFMH-WPCM)
Saccharomyces cerevisiae ATCC ® 9763™ Designation: NRRL Y-567 [CBS 2978, CBS 5900, CCY 21-4-48, CCY 21-4-54, NCTC 10716, NCTC 7239, NCYC 87, Pattee 6, PCI M-50] Application: Assay of amphotericin Assay of amphotericin B fungizone Assay of anisomycin Assay of antifongine Assay of candicidin Assay of natamycin pimaricin, tennecetin Assay of nystatin fungicidin Media testing Produces arginase Produces ethyl alcohol ethanol Food testing Pharmaceutical and Personal Care Produces histone deacetylase Produces nicotinic acid niacin Sterility testing Susceptibility testing Testing disinfectants Testing fungicides Produces ethanol from saccharified whole corn mash Reference strain for performance testing culture media listed by the ISO TC 34 SC 9 Joint Working Group 5 in the ISO 11133 and by the Working Party on Culture Media of the International Committee on Food Microbiology and Hygiene (ICFMH-WPCM)
ATC code G01 Gynecological antiinfectives and antiseptics is a therapeutic subgroup of the Anatomical Therapeutic Chemical Classification System, a system of alphanumeric codes developed by the WHO for the classification of drugs and other medical products. Subgroup G01 is part of the anatomical group G Genito-urinary system and sex hormones. Codes for veterinary use (ATCvet codes) can be created by placing the letter Q in front of the human ATC code: for example, QG01. ATCvet codes without corresponding human ATC codes are cited with the leading Q in the following list. National issues of the ATC classification may include additional codes not present in this list, which follows the WHO version. G01AA01 Nystatin G01AA02 Natamycin G01AA03 Amphotericin B G01AA04 Candicidin G01AA05 Chloramphenicol G01AA06 Hachimycin G01AA07 Oxytetracycline G01AA08 Carfecillin G01AA09 Mepartricin G01AA10 Clindamycin G01AA11 Pentamycin G01AA51 Nystatin, combinations QG01AA55 Choramphenicol, combinations QG01AA90 ...
Ortiz, Adriana, Ana Esperanza Franco-Molano & Mauricio Bacci Jr. A new species of Leucoagaricus (Agaricaceae) from Colombia. Mycotaxon 106: 371-378. 2008. ABSTRACT: A new taxon of Leucoagaricus is proposed as L. amazonicus. The collection representing this species was collected in the lowlands of the Amazonas Department, Colombia, on a dump produced by ants belonging to Acromyrmex octospinosus. The very particular habitat, the small size and dark brown basidiomata that stain yellowish when bruised, the peronate inferior annulus, and the cheilocystidia which are relatively short, capitate and filled with dense brown contents are some of the features of this species. KEYWORDS: Agaricales, taxonomy, Amazonia ...
Attine ants live in symbiosis with a basidiomycetous fungus that they rear on a substrate of plant material. This indirect herbivory implies that the symbiosis is likely to be nitrogen deprived, so that specific mechanisms may have evolved to enhance protein availability. We therefore hypothesized that fungal proteinase activity may have been under selection for efficiency and that different classes of proteinases might be involved. We determined proteinase activity profiles across a wide pH range for fungus gardens of 14 Panamanian species of fungus-growing ants, representing eight genera. We mapped these activity profiles on an independently obtained molecular phylogeny of the symbionts and show that total proteinase activity in lower attine symbionts peaks at ca. pH 6. The higher attine symbionts that have no known free-living relatives had much higher proteinase activities than the lower attine symbionts. Their total in vitro proteinase activity peaked at pH values around 5, which is close to the pH
The social Hymenoptera have distinct larval and adult stages separated by metamorphosis, which implies striking remodeling of external and internal body structures during the pupal stage. This imposes challenges to gut symbionts as existing cultures are lost and may or may not need to be replaced. To elucidate the extent to which metamorphosis interrupts associations between bacteria and hosts, we analysed changes in gut microbiota during development and traced the transmission routes of dominant symbionts from the egg to adult stage in the leaf-cutting ants Acromyrmex echinatior and Atta cephalotes, which are both important functional herbivores in the New World tropics. Bacterial density remained similar across the developmental stages of Acromyrmex, but Atta brood had very low bacterial prevalences suggesting that bacterial gut symbionts are not actively maintained. We found that Wolbachia was the absolute dominant bacterial species across developmental stages in Acromyrmex and we confirmed that Atta
But the story can get more complicated. Imagine a symbiosis with four co-evolving partners: three of them are engaged in a mutualistic relationship, while the fourth one is a parasite. Thats the beautiful case of fungus-growing ants. In their underground nests, the ants grow a mushroom-like fungus by feeding it with plant materials or other organic matter. In turn, the fungus serves as food for the ants (yes, this is agriculture!). But every garden has its pests, and the ants farm is home for the Escovopsis mold. Escovopsis is a specialized pest, found only on the crop of farming ants. To battle the parasite, the ants combine special behaviors and microbial symbionts. These insects carry a bunch of antibiotic-producing actinomycetes in elaborate cuticular crypts, supported by unique exocrine glands. The symbiotic bacteria produce substances that specifically inhibit Escovopsis growth. Although initially identified as Streptomyces, the actinomycete symbionts appear to belong to the ...
Brown DW, Cheung F, Proctor RH, Butchko RA, Zheng L, Lee Y, Utterback T, Smith S, Feldblyum T, Glenn AE, Plattner RD, Kendra DF, Town CD, Whitelaw CA ...
To unsubscribe from si-list or si-list-digest: send e-mail to [email protected] In the BODY of message put: UNSUBSCRIBE si-list or UNSUBSCRIBE si-list-digest, for more help, put HELP ...
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[118 Pages Report] Check for Discount on Global P-Aminobenzoic Acid Market Research Report 2016 report by QYResearch Group. Notes: Production, means the output of P-Aminobenzoic Acid Revenue,...
The present disclosure provides compositions and methods for the biosynthetic production of acetaminophen, p-aminophenol, and p-aminobenzoic acid and the purification of biologically derived acetaminophen.
Leafcutter ants, signature denizens of New World tropical forests, are unique in their ability to harvest fresh leaves to cultivate a nutrient-rich fungus as food.. Now, this mutualism -- a complicated interplay of ants, fungi and a suite of bacteria -- is coming into sharper focus as a team of University of Wisconsin-Madison researchers has published the complete genome of the leafcutter ant, Atta cephalotes.. The study, published today (Feb. 10, 2011) in the journal Public Library of Science (PLoS) Genetics, by an international team led by UW-Madison bacteriology professors Cameron Currie and Garret Suen, illustrates how lifestyle can remake an animals genetic blueprint over the course of evolutionary history.. The genome, the first for a leafcutter ant, reveals that the insect has shed genes that other ant species use to help acquire nutrients. The leafcutter, which cannot survive without its fungus food, has apparently slimmed its genome to get rid of genes it no longer needs due to its ...
FR-900520 and FR-900523, novel neutral macrolide immunosuppressants, were isolated from the cultured broth of Streptomyces hygroscopicus subsp. yakushimaensis No. 7238. Their molecular formulae were determined as C43H69NO12 and C42H67NO12, respectively. The compounds suppressed immune response in vitro. IC50 values of FR-900520 and FR-900523 for mouse mixed lymphocyte reaction were 0.55 nM and 1.6 nM, respectively. FR-900520, the major component, clearly prolonged skin allograft survival in rats.
Streptomyces griseus EshA protein: developmentally regulated protein, required for sporogenic hyphal branches in Streptomyces griseus; amino acid sequence in first source
Biosynthetic Production of 4-Amino 4-Deoxychorismate (Adc) and [3R,4R]-4-Amino-3-Hydroxycyclohexa-1,5-Diene-1-Carboxylic Acid (3,4-Cha) - The invention relates to a process for the biosynthetic production of 4-amino-4-deoxychorismate (ADC) performed fermentatively in vivo with a 4-amino-4-deoxychorismate synthase, preferably a PabAB bipartite protein (which may be a fusion protein), at an increased level of activity, thereby obtaining a broth comprising ADC and 4-amino-4-deoxyprephenate (ADP), that are recovered. The invention also relates to a further process of converting the ADP into p-aminophenylalanine. The invention, moreover relates to biosynthetic production of [3R,4R]-4-amino-3-hydroxycyclohexa-1,5-diene-1-carboxylic acid (3,4-CHA), by concerted action of such 4-amino-4-deoxychorismate synthase and of an enzyme capable of converting isochorismate into [5S,6S]-5,6 dihydroxycyclohexa-1,3-diene-1-carboxylic acid (2,3-CHD), preferably a phenazine biosynthesis protein PhzD, including ...
Ten years ago, Cameron Currie, a microbial ecologist then at the University of Toronto in Ontario, Canada, discovered that leaf-cutting ants carry colonies of actinomycete bacteria on their bodies (C. R. Currie et al. Nature 398, 701-704; 1999). The bacteria churn out an antibiotic that protects the ants fungal crops from associated parasitic fungi (such as Escovopsis). On 29 March, Currie, Jon Clardy at the Harvard Medical School in Boston and their colleagues reported that they had isolated and purified one of these antifungals, which they named dentigerumycin, and that it is a chemical that has never been previously reported (D.-C. Oh et al. Nature Chem. Bio. doi: 10.1038/nchembio.159; 2009). The antifungal slowed the growth of a drug-resistant strain of the fungus Candida albicans, which causes yeast infections in people ...
The Species 2000/ITIS Catalogue of Life : 2006 Annual Checklist is a comprehensive index of all known plants, animals, fungi and micro-organisms. It can be used to search multiple databases simultaneously for the scientific name of an organism.
ID C6WDR1_ACTMD Unreviewed; 187 AA. AC C6WDR1; DT 22-SEP-2009, integrated into UniProtKB/TrEMBL. DT 22-SEP-2009, sequence version 1. DT 07-JUN-2017, entry version 53. DE RecName: Full=Ferritin {ECO:0000256,RuleBase:RU361145}; DE EC=1.16.3.2 {ECO:0000256,RuleBase:RU361145}; GN OrderedLocusNames=Amir_0082 {ECO:0000313,EMBL:ACU34056.1}; OS Actinosynnema mirum (strain ATCC 29888 / DSM 43827 / NBRC 14064 / IMRU OS 3971). OC Bacteria; Actinobacteria; Pseudonocardiales; Pseudonocardiaceae; OC Actinosynnema. OX NCBI_TaxID=446462 {ECO:0000313,EMBL:ACU34056.1, ECO:0000313,Proteomes:UP000002213}; RN [1] {ECO:0000313,EMBL:ACU34056.1, ECO:0000313,Proteomes:UP000002213} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC 29888 / DSM 43827 / NBRC 14064 / IMRU 3971 RC {ECO:0000313,Proteomes:UP000002213}; RX PubMed=21304636; DOI=10.4056/sigs.21137; RA Land M., Lapidus A., Mayilraj S., Chen F., Copeland A., Del Rio T.G., RA Nolan M., Lucas S., Tice H., Cheng J.F., Chertkov O., Bruce D., RA Goodwin ...
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Fr-009 found in: Ceramic Orange Seal ABEC 7 Manufacturer/Model By Series, Ceramic Lightning ABEC 5 Manufacturer/Model By Series, ABU GARCIA 4600C3 ..
Detail záznamu - tmRNA of Streptomyces collinus and Streptomyces griseus during the growth and in the presence of antibiotics - Detail záznamu - Knihovna Akademie věd České republiky
Asturias, J. A.; Martín, J. F.; Liras, P (1994). "Biosynthesis and phosphate control of candicidin by Streptomyces acrimycini ...
The following polyenes are used as antibiotics for humans: amphotericin B, nystatin, candicidin, pimaricin, methyl partricin, ...
... candicidin, candidin, and others. Two of these, streptomycin and neomycin, have found extensive application in the treatment of ...
G01AA01 Nystatin G01AA02 Natamycin G01AA03 Amphotericin B G01AA04 Candicidin G01AA05 Chloramphenicol G01AA06 Hachimycin G01AA07 ...
Candex candicidin (INN) Candin Candistatin candocuronium iodide (INN) candoxatril (INN) candoxatrilat (INN) canertinib (USAN) ...
... candicidin MeSH D09.408.477.250 --- erythromycin MeSH D09.408.477.250.050 --- azithromycin MeSH D09.408.477.250.100 --- ...
... candicidin MeSH D02.540.505.187 --- epothilones MeSH D02.540.505.250 --- erythromycin MeSH D02.540.505.250.050 --- azithromycin ...
Amphotericin B Candicidin Filipin - 35 carbons, binds to cholesterol (toxic) Hamycin Natamycin - 33 carbons, binds well to ...
... candicidin, and candidin. Of these, streptomycin and neomycin found extensive application in the treatment of numerous ...
... candicidin MeSH D04.345.349.156 --- cytochalasins MeSH D04.345.349.156.370 --- cytochalasin b MeSH D04.345.349.156.450 --- ...
This bioactive compound was named candicidin, because of its high activity on Candida albicans. "Product information Candicidin ... Candicidin is an antifungal compound obtained from Streptomyces griseus. It is active against some fungi including Candida ... Selman A. Waksman, Hubert A. Lechevalier & Carl P. Schaffner: Candicidin and other Polyenic Antifungal Antibiotics, 1965, 33, ... Candicidin is administered intravaginally in the treatment of vulvovaginal candidiasis. ...
It is commonly available without a prescription in various dosage forms, such as a topical cream, ointment, or vaginal suppository. It is also available as an oral troche or throat lozenge as a prescription only. Topically, clotrimazole is used for vulvovaginal candidiasis (yeast infection) or yeast infections of the skin. For vulvovaginal candidiasis (yeast infection), clotrimazole tablets and creams are inserted into the vagina. Topical clotrimazole is usually not effective in treatment of fungal infections of the scalp or nails.[citation needed] When using over-the-counter drug clotrimazole products, use should be discontinued if condition does not improve after treatment for 2 weeks for jock itch or after 4 weeks for athlete's foot or ringworm.[6] Throat lozenge preparations are used for oropharyngeal candidiasis (oral thrush) or prevention of oral thrush in people with neutropenia.[6] Clotrimazole is usually used 5 times daily for 14 days for oral thrush, twice daily for 2 to 8 weeks for ...
... (trade names Oxistat in the US, Oxizole in Canada) is an antifungal medication typically administered in a cream or lotion to treat skin infections, such as athlete's foot, jock itch and ringworm. It can also be prescribed to treat the skin rash known as tinea versicolor, caused by systemic yeast overgrowth (Candida spp.). ...
... has been used for decades in the food industry as a hurdle to fungal outgrowth in dairy products and other foods. Potential advantages for the usage of natamycin might include the replacement of traditional chemical preservatives, a neutral flavor impact, and less dependence on pH for efficacy, as is common with chemical preservatives. It can be applied in a variety of ways: as an aqueous suspension (such as mixed into a brine) sprayed on the product or into which the product is dipped, or in powdered form (along with an anticaking agent such as cellulose) sprinkled on or mixed into the product. While not currently approved for use on meats in the United States, some countries allow natamycin to be applied to the surface of dry and fermented sausages to prevent mold growth on the casing. Also, natamycin is approved for various dairy applications in the United States. More specifically, natamycin is commonly used in products such as cream cheeses, cottage cheese, sour cream, yogurt, ...
... is found primarily in sour milk products, such as koumiss, laban, yogurt, kefir, and some cottage cheeses. The casein in fermented milk is coagulated (curdled) by lactic acid. Lactic acid is also responsible for the sour flavor of sourdough bread. In lists of nutritional information lactic acid might be included under the term "carbohydrate" (or "carbohydrate by difference") because this often includes everything other than water, protein, fat, ash, and ethanol.[37] If this is the case then the calculated food energy may use the standard 4 calories per gram that is often used for all carbohydrates. But in some cases lactic acid is ignored in the calculation.[38] The energy density of lactic acid is 362 kilocalories (1,510 kJ) per 100 g.[39] In beer brewing some styles of beer (sour beer) purposely contain lactic acid. Most commonly this is produced naturally by various strains of bacteria. These bacteria ferment sugars into acids, unlike yeast, which ferment sugar into ethanol. One ...
... candicidin, candidin, and others. Waksman, along with graduate student Albert Schatz (1920-2005), discovered streptomycin-a ...
Candicidin biosynthetic gene cluster is widely distributed among Streptomyces spp. isolated from the sediments and the neuston ...
Natamycin has been used for decades in the food industry as a hurdle to fungal outgrowth in dairy products and other foods. Potential advantages for the usage of natamycin might include the replacement of traditional chemical preservatives, a neutral flavor impact, and less dependence on pH for efficacy, as is common with chemical preservatives. It can be applied in a variety of ways: as an aqueous suspension (such as mixed into a brine) sprayed on the product or into which the product is dipped, or in powdered form (along with an anticaking agent such as cellulose) sprinkled on or mixed into the product. While not currently approved for use on meats in the United States, some countries allow natamycin to be applied to the surface of dry and fermented sausages to prevent mold growth on the casing. Also, natamycin is approved for various dairy applications in the United States. More specifically, natamycin is commonly used in products such as cream cheeses, cottage cheese, sour cream, yogurt, ...
This bioactive compound was named candicidin, because of its high activity on Candida albicans. "Product information Candicidin ... Candicidin is an antifungal compound obtained from Streptomyces griseus. It is active against some fungi including Candida ... Selman A. Waksman, Hubert A. Lechevalier & Carl P. Schaffner: Candicidin and other Polyenic Antifungal Antibiotics, 1965, 33, ... Candicidin is administered intravaginally in the treatment of vulvovaginal candidiasis. ...
Here you can find all of the regulations and regulatory lists in which this substance appears, according to the data available to ECHA. This substance has been found in the following regulatory activities (directly, or inheriting the regulatory context of a parent substance):. ...
Biosynthesis of candicidin by Streptomyces acrimycini JI2236 was strongly inhibited by phosphate. p-Aminobenzoic acid (PABA) ... Biosynthesis and phosphate control of candicidin by Streptomyces acrimycini JI2236: effect of amplification of the pabAB gene. ... Formation of PABA synthase and candicidin production was equally sensitive to phosphate regulation in transformants with the ... synthase activity, required for the synthesis of PABA, a candicidin precursor, was reduced by 72% in cells grown in medium ...
Crucially, disrupting the candicidin and antimycin gene clusters in the same strain had no effect on bioactivity against a co- ... Candicidin-producing Streptomyces support leaf-cutting ants to protect their fungus garden against the pathogenic fungus ... However, candicidin and antimycins likely offer protection against other microfungal weeds that infect the attine fungal ...
Candicidin is administered intravaginally in the treatment of vulvovaginal candidiasis. ... Candicidin is an antifungal compound obtained from Streptomyces griseus.It is active against some fungi including Candida ... Candicidin is an antifungal agent used in the treatment of Streptomyves natalenesis. ...
a) The prescription-dispensing requirements of section503(b)(1)(B) of the Federal Food, Drug, and Cosmetic Act are not necessary for the protection of the public health with respect to the following drugs subject to new drug applications: (1) N -Acetyl-p -aminophenol (acetaminophen, p -hydroxy-acetanilid) preparations meeting all the following conditions: (i) The N -acetyl-p -aminophenol is prepared, with or without other drugs, in tablet or other dosage form suitable for oral use in self-medication, and containing no drug limited to prescription sale under the provisions of section 503(b)(1) of the act. (ii) The N -acetyl-p -aminophenol and all other components of the preparation meet their professed standards of identity, strength, quality, and purity. (iii) If the preparation is a new drug, an application pursuant to section 505 (b) of the act is approved for it. (iv) The preparation contains not more than 0.325 gram (5 grains) of N -acetyl-p -aminophenol per dosage unit, or if it is in ...
ii) Any ingredients labeled with any of the following or similar claims. Instant protection or protection immediately upon application. Claims for "all-day" protection or extended wear claims citing a specific number of hours of protection that is inconsistent with the directions for application in 21 CFR 201.327. (30) [Reserved] (b) Any OTC drug product that is labeled, represented, or promoted for the uses specified and containing any active ingredient(s) as specified in paragraph (a) of this section is regarded as a new drug within the meaning of section 210(p) of the Federal Food, Drug, and Cosmetic Act (the Act), for which an approved new drug application under section 505 of the Act and part 314 of this chapter is required for marketing. In the absence of an approved new drug application, such product is also misbranded under section 502 of the Act. (c) Clinical investigations designed to obtain evidence that any drug product labeled, represented, or promoted for the OTC uses and ...
Assay of amphotericin Assay of amphotericin B fungizone Assay of anisomycin Assay of antifongine Assay of candicidin Assay of ... Assay of candicidin. Assay of natamycin pimaricin, tennecetin. Assay of nystatin fungicidin ...
Enzymology of the polyenes pimaricin and candicidin biosynthesis.. Martín JF, Aparicio JF. ...
Candicidin. The risk or severity of adverse effects can be increased when Candicidin is combined with Perhexiline.. Withdrawn. ...
Candicidin. Used in the topical treatment of vulvovaginal candidiasis.. DB01211. Clarithromycin. An alternative medication for ...
Candicidin D, 40-de. methyl-3,7-dideoxo-. 3,7-dihydroxy-N47-m. ethyl-5-oxo-, methy. l ester, cyclic 15,. 19-hemiacetal ...
2009) Candicidin biosynthesis gene cluster is widely distributed among Streptomyces spp. isolated from the sediments and the ... Similarly, candicidin macrolides were synthesized by the majority of the Streptomyces isolates from the three Acromyrmex ... 2009) Candicidin-producing Streptomyces support leaf-cutting ants to protect their fungus garden against the pathogenic fungus ... Because antimycins A1-A4 (4-7), actinomycins, and valinomycins as well as the previously identified candicidin macrolides (11) ...
G01AA04 Candicidin G01AA05 Chloramphenicol G01AA06 Hachimycin G01AA07 Oxytetracycline G01AA08 Carfecillin G01AA09 Mepartricin ...
7.1.3.2 Candicidin. 7.1.3.3 Hamycin. 7.1.3.4 Natamycin. 7.1.3.5 Others. 7.1.4 Allylamines. 7.1.4.1 Lamisil. 7.1.4.2 Terbinafine ...
... candicidin, mepartricin, natamycin, and nystatin), allylamines (e.g., butenafine, and naftifine), imidazoles (e.g., bifonazole ... Candicidin; Carbol-Fuchsin; Chlordantoin; Ciclopirox; Ciclopirox Olamine; Cilofungin; Cisconazole; Clotrimazole; Cuprimyxin; ...
Vanobid - ointment, vaginal (0.6mg/gm) - Candicidin (Levorin) * Vanobid - tablet, vaginal (3mg) - Candicidin (Levorin) ...
Example: Candicidin ointment.. NASAL OINTMENTS. These are used in the topical treatment of nasal mucosa. Drugs get. absorbed ...
Anhydrous candicidin foam compositions US4174295A (en) * 1976-08-13. 1979-11-13. Montedison S.P.A.. Aerosol propellant ... Anhydrous candicidin foam compositions US4174295A (en) * 1976-08-13. 1979-11-13. Montedison S.P.A.. Aerosol propellant ...
Anhydrous candicidin foam compositions US5082667A (en) 1992-01-21. Solid pharmaceutical dosage in tablet triturate form and ...
... and candicidin; anti-parastic compounds such as antimonials. These biological agents include without limitation vinca alkaloids ...
A hierarchical network of four regulatory genes controlling production of the polyene antibiotic candicidin in Streptomyces sp ...
2. any of a group of antibiotic antifungal agents with similar structure, such as amphotericin b, candicidin, or nystatin; they ...
  • We therefore strongly advocate the use of candicidin instead of darodipine in patients with high risks during acataract surgery yesterday and to those references with minimal response to the effect of mydriatic drops. (conservationhawaii.org)
  • This bioactive compound was named candicidin, because of its high activity on Candida albicans. (wikipedia.org)
  • p-Aminobenzoic acid (PABA) synthase activity, required for the synthesis of PABA, a candicidin precursor, was reduced by 72% in cells grown in medium supplemented with 7.5 mM phosphate. (nih.gov)