An antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of TETRAHYDROFOLATE DEHYDROGENASE and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA.
Inhibitors of the enzyme, dihydrofolate reductase (TETRAHYDROFOLATE DEHYDROGENASE), which converts dihydrofolate (FH2) to tetrahydrofolate (FH4). They are frequently used in cancer chemotherapy. (From AMA, Drug Evaluations Annual, 1994, p2033)
A member of the vitamin B family that stimulates the hematopoietic system. It is present in the liver and kidney and is found in mushrooms, spinach, yeast, green leaves, and grasses (POACEAE). Folic acid is used in the treatment and prevention of folate deficiencies and megaloblastic anemia.
Premature separation of the normally implanted PLACENTA from the UTERUS. Signs of varying degree of severity include UTERINE BLEEDING, uterine MUSCLE HYPERTONIA, and FETAL DISTRESS or FETAL DEATH.
A province of Canada, lying between the provinces of Alberta and Manitoba. Its capital is Regina. It is entirely a plains region with prairie in the south and wooded country with many lakes and swamps in the north. The name was taken from the Saskatchewan River from the Cree name Kisiskatchewani Sipi, meaning rapid-flowing river. (From Webster's New Geographical Dictionary, 1988, p1083 & Room, Brewer's Dictionary of Names, 1992, p486)
This drug combination has proved to be an effective therapeutic agent with broad-spectrum antibacterial activity against both gram-positive and gram-negative organisms. It is effective in the treatment of many infections, including PNEUMOCYSTIS PNEUMONIA in AIDS.
Congenital abnormalities caused by medicinal substances or drugs of abuse given to or taken by the mother, or to which she is inadvertently exposed during the manufacture of such substances. The concept excludes abnormalities resulting from exposure to non-medicinal chemicals in the environment.
A nutritional condition produced by a deficiency of FOLIC ACID in the diet. Many plant and animal tissues contain folic acid, abundant in green leafy vegetables, yeast, liver, and mushrooms but destroyed by long-term cooking. Alcohol interferes with its intermediate metabolism and absorption. Folic acid deficiency may develop in long-term anticonvulsant therapy or with use of oral contraceptives. This deficiency causes anemia, macrocytic anemia, and megaloblastic anemia. It is indistinguishable from vitamin B 12 deficiency in peripheral blood and bone marrow findings, but the neurologic lesions seen in B 12 deficiency do not occur. (Merck Manual, 16th ed)
Congenital malformations of the central nervous system and adjacent structures related to defective neural tube closure during the first trimester of pregnancy generally occurring between days 18-29 of gestation. Ectodermal and mesodermal malformations (mainly involving the skull and vertebrae) may occur as a result of defects of neural tube closure. (From Joynt, Clinical Neurology, 1992, Ch55, pp31-41)
Substances that inhibit or prevent the proliferation of NEOPLASMS.
A family of tricyclic hydrocarbons whose members include many of the commonly used tricyclic antidepressants (ANTIDEPRESSIVE AGENTS, TRICYCLIC).
Drugs that bind to but do not activate excitatory amino acid receptors, thereby blocking the actions of agonists.
Cell surface proteins that bind amino acids and trigger changes which influence the behavior of cells. Glutamate receptors are the most common receptors for fast excitatory synaptic transmission in the vertebrate central nervous system, and GAMMA-AMINOBUTYRIC ACID and glycine receptors are the most common receptors for fast inhibition.
Compounds based on 5,6,7,8-tetrahydrofolate.
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
Derivatives of GLUTAMIC ACID. Included under this heading are a broad variety of acid forms, salts, esters, and amides that contain the 2-aminopentanedioic acid structure.
A broad-spectrum excitatory amino acid antagonist used as a research tool.
The D-enantiomer is a potent and specific antagonist of NMDA glutamate receptors (RECEPTORS, N-METHYL-D-ASPARTATE). The L form is inactive at NMDA receptors but may affect the AP4 (2-amino-4-phosphonobutyrate; APB) excitatory amino acid receptors.
A thiol-containing amino acid formed by a demethylation of METHIONINE.
Products in capsule, tablet or liquid form that provide dietary ingredients, and that are intended to be taken by mouth to increase the intake of nutrients. Dietary supplements can include macronutrients, such as proteins, carbohydrates, and fats; and/or MICRONUTRIENTS, such as VITAMINS; MINERALS; and PHYTOCHEMICALS.
A group of water-soluble vitamins, some of which are COENZYMES.
A cobalt-containing coordination compound produced by intestinal micro-organisms and found also in soil and water. Higher plants do not concentrate vitamin B 12 from the soil and so are a poor source of the substance as compared with animal tissues. INTRINSIC FACTOR is important for the assimilation of vitamin B 12.
Any food that has been supplemented with essential nutrients either in quantities that are greater than those present normally, or which are not present in the food normally. Fortified food includes also food to which various nutrients have been added to compensate for those removed by refinement or processing. (From Segen, Dictionary of Modern Medicine, 1992)
An agonist at two subsets of excitatory amino acid receptors, ionotropic receptors that directly control membrane channels and metabotropic receptors that indirectly mediate calcium mobilization from intracellular stores. The compound is obtained from the seeds and fruit of Quisqualis chinensis.
An amino acid that, as the D-isomer, is the defining agonist for the NMDA receptor subtype of glutamate receptors (RECEPTORS, NMDA).
Derivatives of BUTYRIC ACID that contain one or more amino groups attached to the aliphatic structure. Included under this heading are a broad variety of acid forms, salts, esters, and amides that include the aminobutryrate structure.
A peptide that is a homopolymer of glutamic acid.
Resistance or diminished response of a neoplasm to an antineoplastic agent in humans, animals, or cell or tissue cultures.
Cell surface receptors that bind to and transport FOLIC ACID, 5-methyltetrahydrofolate, and a variety of folic acid derivatives. The receptors are essential for normal NEURAL TUBE development and transport folic acid via receptor-mediated endocytosis.
An organized and comprehensive program of health care that identifies and reduces a woman's reproductive risks before conception through risk assessment, health promotion, and interventions. Preconception care programs may be designed to include the male partner in providing counseling and educational information in preparation for fatherhood, such as genetic counseling and testing, financial and family planning, etc. This concept is different from PRENATAL CARE, which occurs during pregnancy.
The relationship between the dose of an administered drug and the response of the organism to the drug.
Drugs that are used to treat RHEUMATOID ARTHRITIS.
Cell surface receptors that bind signalling molecules released by neurons and convert these signals into intracellular changes influencing the behavior of cells. Neurotransmitter is used here in its most general sense, including not only messengers that act to regulate ion channels, but also those which act on second messenger systems and those which may act at a distance from their release sites. Included are receptors for neuromodulators, neuroregulators, neuromediators, and neurohumors, whether or not located at synapses.
One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter.
Methods of investigating the effectiveness of anticancer cytotoxic drugs and biologic inhibitors. These include in vitro cell-kill models and cytostatic dye exclusion tests as well as in vivo measurement of tumor growth parameters in laboratory animals.
A folic acid derivative used as a rodenticide that has been shown to be teratogenic.
The process of finding chemicals for potential therapeutic use.
An enzyme of the oxidoreductase class that catalyzes the reaction 7,8-dihyrofolate and NADPH to yield 5,6,7,8-tetrahydrofolate and NADPH+, producing reduced folate for amino acid metabolism, purine ring synthesis, and the formation of deoxythymidine monophosphate. Methotrexate and other folic acid antagonists used as chemotherapeutic drugs act by inhibiting this enzyme. (Dorland, 27th ed) EC 1.5.1.3.
A noncompetitive antagonist at GABA-A receptors and thus a convulsant. Picrotoxin blocks the GAMMA-AMINOBUTYRIC ACID-activated chloride ionophore. Although it is most often used as a research tool, it has been used as a CNS stimulant and an antidote in poisoning by CNS depressants, especially the barbiturates.
The molecular designing of drugs for specific purposes (such as DNA-binding, enzyme inhibition, anti-cancer efficacy, etc.) based on knowledge of molecular properties such as activity of functional groups, molecular geometry, and electronic structure, and also on information cataloged on analogous molecules. Drug design is generally computer-assisted molecular modeling and does not include pharmacokinetics, dosage analysis, or drug administration analysis.
A ubiquitously expressed folic acid transporter that functions via an antiporter mechanism which is coupled to the transport of organic phosphates.
Derivatives of folic acid (pteroylglutamic acid). In gamma-glutamyl linkage they are found in many tissues. They are converted to folic acid by the action of pteroylpolyglutamate hydrolase or synthesized from folic acid by the action of folate polyglutamate synthetase. Synthetic pteroylpolyglutamic acids, which are in alpha-glutamyl linkage, are active in bacterial growth assays.
Tumors or cancer of the human BREAST.
A cell line derived from cultured tumor cells.
Treatments with drugs which interact with or block synthesis of specific cellular components characteristic of the individual's disease in order to stop or interrupt the specific biochemical dysfunction involved in progression of the disease.
Organic compounds that generally contain an amino (-NH2) and a carboxyl (-COOH) group. Twenty alpha-amino acids are the subunits which are polymerized to form proteins.
Condition in which the plasma levels of homocysteine and related metabolites are elevated (>13.9 µmol/l). Hyperhomocysteinemia can be familial or acquired. Development of the acquired hyperhomocysteinemia is mostly associated with vitamins B and/or folate deficiency (e.g., PERNICIOUS ANEMIA, vitamin malabsorption). Familial hyperhomocysteinemia often results in a more severe elevation of total homocysteine and excretion into the urine, resulting in HOMOCYSTINURIA. Hyperhomocysteinemia is a risk factor for cardiovascular and neurodegenerative diseases, osteoporotic fractures and complications during pregnancy.
Drugs used to prevent SEIZURES or reduce their severity.
A potent noncompetitive antagonist of the NMDA receptor (RECEPTORS, N-METHYL-D-ASPARTATE) used mainly as a research tool. The drug has been considered for the wide variety of neurodegenerative conditions or disorders in which NMDA receptors may play an important role. Its use has been primarily limited to animal and tissue experiments because of its psychotropic effects.
An isoquinoline alkaloid obtained from Dicentra cucullaria and other plants. It is a competitive antagonist for GABA-A receptors.
Antimetabolites that are useful in cancer chemotherapy.
(2S-(2 alpha,3 beta,4 beta))-2-Carboxy-4-(1-methylethenyl)-3-pyrrolidineacetic acid. Ascaricide obtained from the red alga Digenea simplex. It is a potent excitatory amino acid agonist at some types of excitatory amino acid receptors and has been used to discriminate among receptor types. Like many excitatory amino acid agonists it can cause neurotoxicity and has been used experimentally for that purpose.
Systems for the delivery of drugs to target sites of pharmacological actions. Technologies employed include those concerning drug preparation, route of administration, site targeting, metabolism, and toxicity.
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
Anemia characterized by larger than normal erythrocytes, increased mean corpuscular volume (MCV) and increased mean corpuscular hemoglobin (MCH).
A branched-chain essential amino acid that has stimulant activity. It promotes muscle growth and tissue repair. It is a precursor in the penicillin biosynthetic pathway.
Methods to identify and characterize cancer in the early stages of disease and predict tumor behavior.
Agents which improve the quality of the blood, increasing the hemoglobin level and the number of erythrocytes. They are used in the treatment of anemias.
A non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in the CENTRAL NERVOUS SYSTEM.
VITAMIN B 6 refers to several PICOLINES (especially PYRIDOXINE; PYRIDOXAL; & PYRIDOXAMINE) that are efficiently converted by the body to PYRIDOXAL PHOSPHATE which is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, and aminolevulinic acid. During transamination of amino acids, pyridoxal phosphate is transiently converted into PYRIDOXAMINE phosphate. Although pyridoxine and Vitamin B 6 are still frequently used as synonyms, especially by medical researchers, this practice is erroneous and sometimes misleading (EE Snell; Ann NY Acad Sci, vol 585 pg 1, 1990). Most of vitamin B6 is eventually degraded to PYRIDOXIC ACID and excreted in the urine.
Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries.
Tumors or cancer of the PROSTATE.
A nonclassical folic acid inhibitor through its inhibition of the enzyme dihydrofolate reductase. It is being tested for efficacy as an antineoplastic agent and as an antiparasitic agent against PNEUMOCYSTIS PNEUMONIA in AIDS patients. Myelosuppression is its dose-limiting toxic effect.
Tetrahydrofolates which are substituted by a formyl group at either the nitrogen atom in the 5 position or the nitrogen atom in the 10 position. N(5)-Formyltetrahydrofolate is leukovorin (citrovorum factor) while N(10)-formyltetrahydrofolate is an active coenzyme which functions as a carrier of the formyl group in a number of enzymatic reactions.
That segment of commercial enterprise devoted to the design, development, and manufacture of chemical products for use in the diagnosis and treatment of disease, disability, or other dysfunction, or to improve function.
A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.
The active metabolite of FOLIC ACID. Leucovorin is used principally as an antidote to FOLIC ACID ANTAGONISTS.
A class of ionotropic glutamate receptors characterized by affinity for N-methyl-D-aspartate. NMDA receptors have an allosteric binding site for glycine which must be occupied for the channel to open efficiently and a site within the channel itself to which magnesium ions bind in a voltage-dependent manner. The positive voltage dependence of channel conductance and the high permeability of the conducting channel to calcium ions (as well as to monovalent cations) are important in excitotoxicity and neuronal plasticity.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in neoplastic tissue.
Process that is gone through in order for a drug to receive approval by a government regulatory agency. This includes any required pre-clinical or clinical testing, review, submission, and evaluation of the applications and test results, and post-marketing surveillance of the drug.
A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.
Catalyzes the hydrolysis of pteroylpolyglutamic acids in gamma linkage to pterolylmonoglutamic acid and free glutamic acid. EC 3.4.19.9.
The amount that a health care institution or organization pays for its drugs. It is one component of the final price that is charged to the consumer (FEES, PHARMACEUTICAL or PRESCRIPTION FEES).
Elements of limited time intervals, contributing to particular results or situations.
A nutritional condition produced by a deficiency of VITAMIN B 12 in the diet, characterized by megaloblastic anemia. Since vitamin B 12 is not present in plants, humans have obtained their supply from animal products, from multivitamin supplements in the form of pills, and as additives to food preparations. A wide variety of neuropsychiatric abnormalities is also seen in vitamin B 12 deficiency and appears to be due to an undefined defect involving myelin synthesis. (From Cecil Textbook of Medicine, 19th ed, p848)
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Proteins involved in the transport of FOLIC ACID and folate derivatives across the CELLULAR MEMBRANE.
The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.
The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.
Chemical substances which inhibit the function of the endocrine glands, the biosynthesis of their secreted hormones, or the action of hormones upon their specific sites.
Mutant mice homozygous for the recessive gene "nude" which fail to develop a thymus. They are useful in tumor studies and studies on immune responses.
An agency of the PUBLIC HEALTH SERVICE concerned with the overall planning, promoting, and administering of programs pertaining to maintaining standards of quality of foods, drugs, therapeutic devices, etc.
The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability.
Therapy with two or more separate preparations given for a combined effect.
Organic substances that are required in small amounts for maintenance and growth, but which cannot be manufactured by the human body.
All of the processes involved in increasing CELL NUMBER including CELL DIVISION.
Amounts charged to the patient or third-party payer for medication. It includes the pharmacist's professional fee and cost of ingredients, containers, etc.
Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding.
The concentration of a compound needed to reduce population growth of organisms, including eukaryotic cells, by 50% in vitro. Though often expressed to denote in vitro antibacterial activity, it is also used as a benchmark for cytotoxicity to eukaryotic cells in culture.
Drugs which have received FDA approval for human testing but have yet to be approved for commercial marketing. This includes drugs used for treatment while they still are undergoing clinical trials (Treatment IND). The main heading includes drugs under investigation in foreign countries.
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
Baked food product made of flour or meal that is moistened, kneaded, and sometimes fermented. A major food since prehistoric times, it has been made in various forms using a variety of ingredients and methods.
Time schedule for administration of a drug in order to achieve optimum effectiveness and convenience.
... a drug with a molecular structure similar to that of folic acid which would bind to the folate receptors in cancer cells, ... In the early 1950s, Jane C. Wright used methotrexate, a less toxic drug of the same type, to treat breast cancer. Between 1953 ... Farber hypothesized that leukemia could be treated with a folate antagonist, ... preventing them from receiving the folic acid they needed. Farber was able to use a drug of this type, aminopterin, to achieve ...
They were the first groups to report the use of nitrogen mustard agents and folic acid antagonists as cancer treatments. The ... She also pioneered the use of the drug methotrexate to treat breast cancer and skin cancer (mycosis fungoids). Wright was born ... Folic acid antagonist can block folic acid in the body, which is required for cells to produce certain types of amino acids. By ... and prostate cancer. Methotrexate is still one of the main chemotherapy drugs used today to treat many types of cancer, and it ...
Diminishing the toxicity associated with overdosage of folic acid antagonists or impaired methotrexate elimination. The ... Marcial G (June 15, 2009). "Cancer drugs from Spectrum". Businessweek: 67. "RAnDomized Trial of SPI-2012 Versus Pegfilgrastim ... Fusilev (Levoleucovorin) for injection is a drug that was approved by the U.S. Food and Drug Administration in 2008 for the US ... Evomela (melphalan) is an alkalyating drug for multiple myeloma. As of 2019, a number of drugs are investigated in clinical ...
May 2013). "Folic acid and folinic acid for reducing side effects in patients receiving methotrexate for rheumatoid arthritis ... Clinical Colorectal Cancer. 8 (4): 200-6. doi:10.3816/CCC.2009.n.034. PMID 19822510. Drugs.com (2008-05-07). "FDA Approves ... in combination with the folic acid antagonists pyrimethamine and sulfadiazine. Folinic acid is also used in the treatment of ... Folinic acid should be distinguished from folic acid (vitamin B9). However, folinic acid is a vitamer for folic acid and has ...
The era of cancer chemotherapy began in the 1940s with the first use of nitrogen mustards and folic acid antagonist drugs. The ... These analogues - first aminopterin and then amethopterin (now methotrexate) were antagonistic to folic acid, and blocked the ... Sidney Farber, a pathologist at Harvard Medical School, studied the effects of folic acid on leukemia patients. Folic acid, a ... "Temporary remissions in acute leukemia in children produced by folic acid antagonist, 4-aminopteroyl-glutamic acid". N. Engl. J ...
It acts by blocking the body's use of folic acid. Methotrexate was first made in 1947 and initially was used to treat cancer, ... Wright JC, Prigot A, Wright B, Weintraub S, Wright LT (July 1951). "An evaluation of folic acid antagonists in adults with ... Wright's group was the first to demonstrate use of the drug in solid tumors, as opposed to leukemias, which are a cancer of the ... The development of folic acid analogues had been prompted by the discovery that the administration of folic acid worsened ...
... is classified as a folic acid antagonist. It works by inhibiting folic acid metabolism and therefore the making ... In Canada, the drug was reportedly discontinued in 2013, but hospitals may make the drug in-house when it is needed. As of ... There is concern that it may increase the risk of cancer. While occasionally used in pregnancy it is unclear if pyrimethamine ... Other antifolate agents such as methotrexate and trimethoprim may potentiate the antifolate actions of pyrimethamine, leading ...
He subsequently discovered folic acid as a cure for tropical sprue. He discovered methotrexate, a chemotherapy drug still used ... After his work on folic acid and with considerable input from Dr. Sidney Farber, he developed the important anti-cancer drug ... "Temporary remissions in acute leukemia in children produced by folic acid antagonist, 4-aminopteroyl-glutamic acid (aminopterin ... At Lederle, he developed a method to synthesize folic acid, Vitamin B9, based on work by Lucy Wills to isolate folic acid as a ...
... both folic acid antagonists, could produce remission in patients with acute leukemia, and for "his constant leadership in the ... a drug used to treat blood cancer, to treat her sickle cell disease. The treatment worked and Hydroxyurea is now broadly used ... Sidney Farber received the Lasker in 1966 for his 1947 discovery that a combination of aminopterin and methotrexate, ... and to Dana-Farber Cancer Institute. Dana-Farber and Children's jointly operate the Dana-Farber/Boston Children's Cancer and ...
... folate antagonist - FOLFOX - folic acid - follicular large cell lymphoma - follicular mixed cell lymphoma - follicular thyroid ... metastatic cancer - metasynchronous - meteorism - methotrexate - methoxsalen - Methoxy polyethylene glycol-epoetin beta - ... drug tolerance - dry orgasm - DTGM fusion protein - ductal carcinoma - ductal carcinoma in situ - ductal lavage - Dukes' ... cancer induction - Cancer Information Service - cancer of unknown primary origin - cancer stem cell - cancer vaccine - Cancer. ...
... inhibitors to the substrates of the enzymes they target is seen in the figure comparing the drug methotrexate to folic acid. ... Current Cancer Drug Targets. 3 (3): 193-203. doi:10.2174/1568009033481967. PMID 12769688. Hostettmann K, Borloz A, Urbain A, ... Cholinesterase Inhibitors & Other Pharmacologic Antagonists to Neuromuscular Blocking Agents.". Morgan & Mikhail's Clinical ... Methotrexate versus folate The most common uses for enzyme inhibitors are as drugs to treat disease. Many of these inhibitors ...
"A quantitative comparison of the antileukemic effectiveness of two folic acid antagonists in mice". J. Natl. Cancer Inst. 15 (6 ... Aminopterin (or 4-aminopteroic acid), the 4-amino derivative of folic acid, is an antineoplastic drug with immunosuppressive ... The use of aminopterin in cancer treatment was supplanted in the 1950s by methotrexate due to the latter's better therapeutic ... dosed mongrel dogs subcutaneously with aminopterin and folic acid simultaneously to test whether folic acid can rescue animals ...
Ferrous salt Ferrous salt/folic acid (ferrous salt + folic acid) Folic acid Hydroxocobalamin Erythropoiesis-stimulating agentsα ... For the management of cancer pain Alternatives limited to hydromorphone and oxycodone For the management of cancer pain. ... World Health Organization (1977). The selection of essential drugs : report of a WHO expert committee [meeting held in Geneva ... α Acetic acid Budesonide Ciprofloxacin Xylometazoline Allopurinol Chloroquine Azathioprineα Hydroxychloroquineα Methotrexateα ...
... or reverse the toxic effects of methotrexate. Folic acid supplements have little established role in cancer chemotherapy. The ... Forney B (2017). "Folic Acid for Veterinary Use". Wedgewood Pharmacy. Retrieved 21 September 2019. "Folic Acid". Drug ... "Temporary remissions in acute leukemia in children produced by folic acid antagonist, 4-aminopteroyl-glutamic acid". The New ... Folate and folic acid are the preferred synonyms for pteroylglutamate and pteroylglutamic acid, respectively. "Folic Acid". ...
Biotin deficiency Carotenemia Essential fatty acid deficiency Folic acid deficiency Hypervitaminosis A Hypovitaminosis A ( ... HIV disease-related drug reaction Hydroxyurea dermopathy Injection site reaction Iododerma Leukotriene receptor antagonist- ... Thiers BH (1986). "Dermatologic manifestations of internal cancer". CA Cancer J Clin. 36 (3): 130-48. doi:10.3322/canjclin.36.3 ... Methotrexate-induced papular eruption Mixed connective tissue disease (Sharp's syndrome, undifferentiated connective tissue ...
Due to these safety concerns it is often recommended that methotrexate is combined with folic acid in order to prevent toxicity ... Sarcoidosis can also follow cancer or occur concurrently with cancer. There have been reports of hairy cell leukemia, acute ... If drug intervention is indicated, a step-wise approach is often used to explore alternatives in order of increasing side ... Maneiro JR, Salgado E, Gomez-Reino JJ, Carmona L (August 2012). "Efficacy and safety of TNF antagonists in sarcoidosis: data ...
Effective contraception must be used with certain drug therapy. [113] Both male and female partners receiving methotrexate ... 1] ; administer folic acid if sulfasalazine is used). Aminosalicylates have only a weak effect in preventing recurrence after ... Risk of cancer in inflammatory bowel disease: going up, going down, or still the same?. Curr Opin Gastroenterol. 2016 Jul. 32(4 ... Vedolizumab (Entyvio), another integrin antagonist, is approved for Crohn disease and ulcerative colitis. [103] It is specific ...
Effective contraception must be used with certain drug therapy. [113] Both male and female partners receiving methotrexate ... 1] ; administer folic acid if sulfasalazine is used). Aminosalicylates have only a weak effect in preventing recurrence after ... Risk of cancer in inflammatory bowel disease: going up, going down, or still the same?. Curr Opin Gastroenterol. 2016 Jul. 32(4 ... Vedolizumab (Entyvio), another integrin antagonist, is approved for Crohn disease and ulcerative colitis. [103] It is specific ...
Methotrexate (Rheumatrex, Trexall, Otrexup). *View full drug information. MTX is a folic acid antagonist that is approved for ... Cardiovascular and Cancer Risk with Tofacitinib in Rheumatoid Arthritis. N Engl J Med. 2022 Jan 27. 386 (4):316-326. [QxMD ... Sarilumab Plus Methotrexate in Patients With Active Rheumatoid Arthritis and Inadequate Response to Methotrexate: Results of a ... Methotrexate monotherapy and methotrexate combination therapy with traditional and biologic disease modifying antirheumatic ...
Methotrexate and trimethoprim are both folate antagonists that inhibit dihydrofolate reductase. Anticonvulsant drugs can ... Kimmel Cancer Center, Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania. Disclosure: ... Pleasedo not use this form to submit personal or patient medical information or to report adverse drug events. You are ...
This approach also allowed Wright to determine if specific drugs such as methotrexate, a folic acid antagonist, would help ... On the road to being the best, Jones said, her mother set a goal of curing cancer. National Cancer Research Month is a fitting ... "They also performed early research into the clinical efficacy and toxicity of folic acid antagonists, documenting responses in ... In 1948, Jane C. Wright joined her father at Harlem Hospital's Cancer Research Foundation. There the duo explored the cancer- ...
... in which competitive antagonism of PABA prevents the formation of folic acid, inhibiting bacterial growth. Dapsone therapy with ... View full drug information. Spironolactone is an aldosterone antagonist that inhibits ovarian and adrenal production of ... Lapins J, Ye W, Nyren O, Emtestam L. Incidence of cancer among patients with hidradenitis suppurativa. Arch Dermatol. 2001 Jun ... Different immunosuppressive medications, including methotrexate and cyclosporin A, have been used in case reports. [2] Before ...
This approach also allowed Wright to determine if specific drugs such as methotrexate, a folic acid antagonist, would help ... On the road to being the best, Jones said, her mother set a goal of curing cancer. National Cancer Research Month is a fitting ... "They also performed early research into the clinical efficacy and toxicity of folic acid antagonists, documenting responses in ... In 1948, Jane C. Wright joined her father at Harlem Hospital's Cancer Research Foundation. There the duo explored the cancer- ...
Effective contraception must be used with certain drug therapy. [113] Both male and female partners receiving methotrexate ... 1] ; administer folic acid if sulfasalazine is used). Aminosalicylates have only a weak effect in preventing recurrence after ... Risk of cancer in inflammatory bowel disease: going up, going down, or still the same?. Curr Opin Gastroenterol. 2016 Jul. 32(4 ... Vedolizumab (Entyvio), another integrin antagonist, is approved for Crohn disease and ulcerative colitis. [103] It is specific ...
Effective contraception must be used with certain drug therapy. [113] Both male and female partners receiving methotrexate ... 1] ; administer folic acid if sulfasalazine is used). Aminosalicylates have only a weak effect in preventing recurrence after ... Risk of cancer in inflammatory bowel disease: going up, going down, or still the same?. Curr Opin Gastroenterol. 2016 Jul. 32(4 ... Vedolizumab (Entyvio), another integrin antagonist, is approved for Crohn disease and ulcerative colitis. [103] It is specific ...
Its mechanism of action is similar to that of sulfonamides in which competitive antagonists of para-aminobenzoic acid (PABA) ... J Drugs Dermatol. 2005 May-Jun. 4(3):374-7. [QxMD MEDLINE Link]. ... prevent the formation of folic acid, inhibiting bacterial ... Cutaneous Crohn's disease mimicking Melkersson-Rosenthal syndrome: treatment with methotrexate. J Eur Acad Dermatol Venereol. ... A Genitourinary Overview of Bladder and Prostate Cancers 0.5 CE Credits You are being redirected to Medscape Education ...
Folate (folic acid). Mayoclinic.com. Available at https://www.mayoclinic.org/drugs-supplements-folate/art-20364625. Accessed: ... methotrexate and other antifolates, sulfonamides (competitive inhibitors of 4-aminobenzoic acid), and valproic acid. ... Lahner E, Capasso M, Carabotti M, Annibale B. Incidence of cancer (other than gastric cancer) in pernicious anaemia: A ... Proton Pump Inhibitors, H2-Receptor Antagonists, Metformin, and Vitamin B-12 Deficiency: Clinical Implications. Adv Nutr. 2018 ...
Drug eruptions can mimic a wide range of dermatoses. The morphologies are myriad and include morbilliform (most common, see ... TNF-alpha antagonists can also cause Sweet-like hypersensitivity reactions and neutrophilic eccrine hidradenitis in addition to ... Tamoxifen, an antiestrogenic agent, has been widely used as adjuvant hormonal therapy in the treatment of breast cancer. ... Sweet syndrome - All-trans -retinoic acid, celecoxib, granulocyte colony-stimulating factor, nitrofurantoin, oral ...
Drug eruptions can mimic a wide range of dermatoses. The morphologies are myriad and include morbilliform (most common, see ... TNF-alpha antagonists can also cause Sweet-like hypersensitivity reactions and neutrophilic eccrine hidradenitis in addition to ... Tamoxifen, an antiestrogenic agent, has been widely used as adjuvant hormonal therapy in the treatment of breast cancer. ... Sweet syndrome - All-trans -retinoic acid, celecoxib, granulocyte colony-stimulating factor, nitrofurantoin, oral ...
Effective contraception must be used with certain drug therapy. [113] Both male and female partners receiving methotrexate ... 1] ; administer folic acid if sulfasalazine is used). Aminosalicylates have only a weak effect in preventing recurrence after ... Risk of cancer in inflammatory bowel disease: going up, going down, or still the same?. Curr Opin Gastroenterol. 2016 Jul. 32(4 ... Vedolizumab (Entyvio), another integrin antagonist, is approved for Crohn disease and ulcerative colitis. [103] It is specific ...
... folic acid antagonists such as methotrexate, trimethoprim, pyrimethamine). Some brands may also be used with a certain cancer ... Drug is administered in combination with methotrexate or fluorouracil, which can cause embryo-fetal harm; refer to methotrexate ... Counteracts therapeutic and toxic effects of folic acid antagonists (eg, methotrexate), which act by inhibiting dihydrofolate ... Folic Acid Antagonists Overdose or Impaired Elimination. Indicated for diminishing toxicity and counteracting effects of ...
This approach also allowed Wright to determine if specific drugs such as methotrexate, a folic acid antagonist, would help ... On the road to being the best, Jones said, her mother set a goal of curing cancer. National Cancer Research Month is a fitting ... "They also performed early research into the clinical efficacy and toxicity of folic acid antagonists, documenting responses in ... In 1948, Jane C. Wright joined her father at Harlem Hospitals Cancer Research Foundation. There the duo explored the cancer- ...
... a drug with a molecular structure similar to that of folic acid which would bind to the folate receptors in cancer cells, ... In the early 1950s, Jane C. Wright used methotrexate, a less toxic drug of the same type, to treat breast cancer. Between 1953 ... Farber hypothesized that leukemia could be treated with a folate antagonist, ... preventing them from receiving the folic acid they needed. Farber was able to use a drug of this type, aminopterin, to achieve ...
Introduction: Methotrexate (MTX) is used as a folic acid antagonist in the treatment of many human cancers. Attachment of ... methotrexate-polyethylene glycol-glutamic acid nanoconjugate as targeted. drug delivery system in cancer treatment*. Authors: ... Background: Chronic use of antidepressant drugs often results in drug-induced organ damage, which is mostly undetected and ... Vanillic acid prevents interferon-alpha and cyclosporine A-induced. depressant-like behavior in mice*. Authors: Omid Hajhashemi ...
Drug: Cisplatin Drug: Doxorubicin Hydrochloride Biological: Durvalumab Drug: Gemcitabine Hydrochloride Drug: Methotrexate ... Cancer-specific survival (All Patients) [ Time Frame: From registration to death due to cancer; deaths due to other causes will ... Folic Acid Antagonists. Antirheumatic Agents. To Top. *For Patients and Families. *For Researchers ... Chemotherapy drugs, such as methotrexate, vinblastine, doxorubicin, cisplatin, and gemcitabine work in different ways to stop ...
Introduction: Methotrexate (MTX) is used as a folic acid antagonist in the treatment of many human cancers. Attachment of ... Keywords: Chemotherapy, drug delivery, glutamic acid, methotrexate, nanoconjugate. How to cite this article:. Ahmadi M, ... evaluation of methotrexate-polyethylene glycol-glutamic acid nanoconjugate as targeted drug delivery system in cancer treatment ... evaluation of methotrexate-polyethylene glycol-glutamic acid nanoconjugate as targeted drug delivery system in cancer treatment ...
Impaired use (eg, use of folic acid antagonists such as antiepileptic medications, sulfa antibiotics, or methotrexate) ... Folate deficiency caused by the use of sulfa drugs or other antifolate medications may be addressed by folate supplementation ... American Association for Cancer Research, American Society of Hematology. Disclosure: Nothing to disclose. ... Folic acid is essential for purine biosynthesis. Folic acid absorbed from the diet must be activated to produce active ...
Wholesaler of Anti-Cancer Injection - Kabanat Cabazitaxel 60 Mg Injection, Leuprolide Injection 3.75, Oncomide Injection and ... caused by certain drugs (folic acid antagonists such as methotrexate, trimethoprim, pyrimethamine) ... Altaxel 30mg Injection is an anti-cancer medication used for the treatment of breast cancer, pancreatic cancer and non-small ... 10 mg Injection is an anti-cancer medication used in the treatment of breast cancer and non-small cell lung cancer.. It is ...
This approach also allowed Wright to determine if specific drugs such as methotrexate, a folic acid antagonist, would help ... On the road to being the best, Jones said, her mother set a goal of curing cancer. National Cancer Research Month is a fitting ... "They also performed early research into the clinical efficacy and toxicity of folic acid antagonists, documenting responses in ... In 1948, Jane C. Wright joined her father at Harlem Hospitals Cancer Research Foundation. There the duo explored the cancer- ...
The drug is also used to counteract the toxicity associated with an overdose of folic acid antagonists, and it is also ... It can be used as a rescue drug after a patient receives a high dose of methotrexate therapy, particularly in patients ... This type of cancer usually isnt diagnosed until its advanced. The doctor will often order an X-ray of the chest or CT scan. ... The FDA also warns wholesalers of the drug to examine their inventory. immediately, and to quarantine and discontinue any drugs ...
Folic acid antagonists: methotrexate (Folex). *Leucovorin Rescue- antidote for folic acid antagonists ... Because these drugs target specific receptor sites, they are the least toxic of all cancer drugs. Adverse reactions vary. ... Leucovorin is a reduced form of folic acid, which is readily converted to other reduced folic acid derivatives (e.g., ... Antiandrogens - treatment of metastatic prostate cancer.. *Estrogens - prostate cancer and advanced breast cancer in ...
Toxicity increased by NSAIDs, salicylates, phenytoin, sulfonylureas, sulfonamides, probenecid, folic acid antagonists. May be ... Drugs. TREXALL Rx * Share by Email * Print Generic Name & Formulations: Methotrexate sodium 5mg, 7.5mg, 10mg, 15mg; scored tabs ... Respiratory and thoracic cancers: Indications for: TREXALL Lung cancer (squamous cell and small cell types). ... Toxicity increased by NSAIDs, salicylates, phenytoin, sulfonylureas, sulfonamides, probenecid, folic acid antagonists. May be ...
... folic acid; fosamprenavir (Lexiva); furosemide (Lasix); H2 antagonists such as cimetidine (Tagamet), famotidine (Pepcid), ... and valproic acid (Depakene); methadone (Dolophine, Methadose); methotrexate (Otrexup, Rasuvo, Trexall, Xatmep); ... cancer that begins in the lymph system). Talk to your doctor about the risks of using this medication to treat your condition. ... If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administrations (FDA) ...
... after discovering that folic acid stimulated the progression of leukemia - to administer the folic acid antagonist methotrexate ... how does ANY drug ever make it through to public distribution? Is it possible that a miracle cancer drug has already been ... Brandes new book, Survival: A Medical Memoir (From Drug Discovery To Clinical Cancer Trials), tells the story of his 23-year ... Now he has just published a memoir chronicling his years in cancer research during which he took a drug discovery from the ...
... caused by certain drugs (folic acid antagonists such as methotrexate, trimethoprim, pyrimethamine). HOW TO USE: Take this ... when these drugs are administered concurrently in the palliative therapy of advanced colorectal cancer, the dosage of 5- ... Serves as a cofactor supplement to counteract folic acid antagonists such as methotrexate; leucovorin is an active metabolite ... In treatment of accidental overdosages of folic acid antagonists, IV leucovorin should be administered as promptly as pos-sible ...
The NLM Drug Information Portal gives users a gateway to selected drug information from the National Library of Medicine and ... 37 results for Category equals FOLIC ACID ANTAGONISTS Info. Please enable JavaScript in your browser. Row Number. Result. ... National Cancer Institute Treatment Page (NCI). *National Institute of Allergy and Infectious Diseases (NIAID) ... Methotrexate [USAN:USP:INN:BAN:JAN] 2. Aminopterin 3. Trimethoprim [USAN:USP:INN:BAN:JAN] ...
... and to provide palliative treatment of colorectal cancer. ... the toxic effects of methotrexate and other folate antagonists ... chemically reduced derivatives of folic acid. It is useful as an antidote to drugs which act as folic acid antagonists. ... RxList Drug Page. Drugs.com. Drugs.com Drug Page. Wikipedia. Folinic_acid. FDA label. Download (2.95 MB) ... As leucovorin is a derivative of folic acid, it can be used to increase levels of folic acid under conditions favoring folic ...
Organic Compound; Amine; Amide; Ester; Drug; Nucleic Acid Synthesis Inhibitor; Antineoplastic Agent; Folic Acid Antagonist; ... such as cancer cells, bone marrow cells, and skin cells.; IC50 Value: ; Target: antifolate; in vitro: In normal T cells, ... Potent folic acid antagonist; inhibits dihydrofolate reductase. Also inhibits Ras carboxyl methylation in DKOB8 cells, le ading ... Potent folic acid antagonist; inhibits dihydrofolate reductase. Also inhibits Ras carboxyl methylation in DKOB8 cells, leading ...
... it is useful as an antidote to drugs which act as folic acid antagonists. These tablets are intended for oral administration ... and counteract the effects of impaired methotrexate elimination and of inadvertent overdosages of folic acid antagonists. ... Cancer Treat Rep 1987;71:1122.. 2.. Link MP, Goorin AM, Miser AW et al. The effect of adjuvant chemotherapy on relapse-free ... Drug Interactions. Folic acid in large amounts may counteract the antiepileptic effect of phenobarbital, phenytoin and ...
... drug interactions, warnings, patient labeling, reviews, and related medications including drug comparison and health resources. ... Concurrent use of stable doses of folic acid, oral corticosteroids (≤10 mg/day) and/or nonsteroidal anti-inflammatory drugs ( ... Risk of Cancer *There have been cases of unusual cancers in children and teenage patients using TNF blocking agents, such as ... Methotrexate (MTX) And Other Concomitant Medications. Specific drug interaction studies, including interactions with MTX, have ...
Methotrexate is a folic acid antagonist, active against cancer cells which depend on the folic acid cycle for survival and ... Tamoxifen is not a cure for breast cancer but can reduce the risk for breast cancer. The drug has been around since 1952 and is ... Cyto-k is the first drug-eluting stent (des) approved by the fda. Hydrocodone is also the most commonly used drug in the world ... The drug is not very popular with doctors or patients.. Paxlovid cost of treatment can i get paxlovid at cvs minuteclinic. By ...
Methotrexate metabolite Methotrexate is a folic acid antagonist that is widely used as an immunosuppressant and ... Calcium Levofolinate, a calcium salt of the folinic acid, is used in cancer chemotherapy as an adjuvant. ... Drug-like Compound Libraries Compound Libraries for HTS/HCS Fragment Libraries Characteristic Fragment Libraries General ... Methotrexate is a folic acid antagonist that is widely used as an immunosuppressant and chemotherapeutic agent. Methotrexate is ...
... l Folinic acid (Leucovorin)). Counteracts the effects of folic acid antagonists such as methotrexate, which acts by inhibiting ... Pancreatic cancer ‎ ‎. Patient drug information. *Levoleucovorin (Fusilev) package insert[1]. *Levoleucovorin (Fusilev) patient ... and counteract the effects of impaired methotrexate elimination and of inadvertent overdosage of folic acid antagonists." " ... Class/mechanism: Folic acid analog that is the pharmacologically active isomer of 5-formyl tetrahydrofolic acid (racemic d, ...
Aminopterin and methotrexate are structural analogues of folic acid used in treatment of many cancers including leukemia. These ... Isoniazid (drug used in treatment of TB) is a antagonist of Vitamin B6. ... Vitamin C (Ascorbic acid). *Deficiency may result in Scurvy. It is characterized by spongy and sore gums, loose teeth, anemia, ... Vitamin B5 (pantothenic acid or chick anti dermatitis factor). *Burning feet syndrome : Pain and numbness in the toes, ...
The Cancer Medications Enquiry Database (CanMED) is a two-part resource for cancer drug treatment related studies. ... Folic Acid Antagonist. No 1993. 2007. Jan. 1, 1996 In Use. J9390. Vinorelbine Navelbine. 10 mg. Chemotherapy Antimitotic Agent ... Methotrexate Trexall. 2.5 mg. Chemotherapy Antimetabolite. Folic Acid Analog. Yes 1953. Jan. 1, 1995 In Use. ... Methotrexate Trexall. 5 mg. Chemotherapy Antimetabolite. Folic Acid Analog. Yes 1953. Jan. 1, 1994 In Use. ...
Nucleic acid vaccines: Recently, nucleic acid chains, e.G., purine and pyrimidine antagonists: Methotrexate: This folic acid ... Triple response: When a microperforation for traction as with aids) are more likely to have active intra-abdominal cancer, ... Ejection systolic murmur diastolic murmur pulmonary regurgitation remains the drug is then conjugated; chloramphenicol is also ... This reduces the acid subsequently secreted. It is used as a receptor that can readily enter into the porphyrin ring to form + ...
Folic acid antagonists / methanol. 8 hours: 300 mg (3 x 100 mg vials) ... Methotrexate toxic levels. Use in patient with toxic levels and impaired renal function; glucarpidase may also metabolize ... Lipophilic cardiotoxic drugs. Immediately after administration several laboratory tests of patient serum/blood may be ... Highest risk groups for radioiodine-induced cancer are infants, children and pregnant and nursing females. Should only be used ...
... folic acid, reserpine, rifampin, St. Johns wort, theophylline. Variable effects with phenobarbital, valproic acid, and ... Caution with drugs that are highly bound to serum albumin. May decrease T4 serum concentrations, or produce low results in ... Antagonized by antineoplastics (eg, bleomycin, carboplatin, cisplatin, doxorubicin, methotrexate), antivirals (eg, ... H2-antagonists, isoniazid, methylphenidate, omeprazole, phenothiazines, salicylates, sulfonamides, ticlopidine, tolbutamide, ...
Methotrexate administration. Folic acid antagonist methotrexate is used in chemotherapy. It eliminates quickly developing cells ... Uterine cancer. The proximal end of the tubes may be under pressure from a tumor, which would prevent the fertilized egg from ... an abortion drug that results in the tubal implantation site peeling off. Both of these treatments would prevent surgical ... Belta Folic Acid The Sense of Ferrous Sulfate Folic Acid Ferrous sulfate (or sulphate) is a medicine used to treat and prevent ...
  • They are indicated for use as rescue therapy following use of high-dose methotrexate in the treatment of osteosarcoma or for diminishing the toxicity associated with inadvertent overdosage of folic acid antagonists. (drugbank.com)
  • In the treatment of accidental overdosage of folic acid antagonists, leucovorin should be administered as promptly as possible. (nih.gov)
  • FDA approved "to diminish the toxicity and counteract the effects of impaired methotrexate elimination and of inadvertent overdosage of folic acid antagonists. (hemonc.org)
  • This phase III trial compares the effect of adding durvalumab to chemotherapy versus chemotherapy alone before surgery in treating patients with upper urinary tract cancer. (clinicaltrials.gov)
  • Chemotherapy drugs, such as methotrexate, vinblastine, doxorubicin, cisplatin, and gemcitabine work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. (clinicaltrials.gov)
  • Li was the first scientist to use chemotherapy to cure widely metastatic, malignant cancer. (wikipedia.org)
  • Li began to treat his choriocarcinoma patients with an antifolate chemotherapy drug called methotrexate. (wikipedia.org)
  • Although the patients did not exhibit what doctors traditionally considered "clinical evidence of cancer", such as tumors, Li continued to treat them with chemotherapy based on their elevated hCG levels. (wikipedia.org)
  • The National Cancer Institute administration disapproved, feeling that by continuing treatment Li was experimenting on his patients and unnecessarily poisoning them with the chemotherapy drug. (wikipedia.org)
  • To that end, he synthesized an antihistamine called DPPE (also known as tesmilifene), which appeared to curb unwanted uterine growth, prevent tumour formation and increase chemotherapy drugs' effectiveness. (lornebrandes.com)
  • Calcium Levofolinate, a calcium salt of the folinic acid, is used in cancer chemotherapy as an adjuvant. (targetmol.com)
  • Folic acid antagonist methotrexate is used in chemotherapy. (bluebeemom.com)
  • The current review presents the progress of cancer treatments, starting with surgery, chemotherapy, radiation and immunotherapy, gene treatment and nanomedicine, giving emphasis to the most common anticancer agents and polychemotherapeutic regimens. (ifnmujournal.com)
  • Cis-diamminedichloroplatinum, vinblastine, and bleomycin combination chemotherapy in disseminated testicular cancer. (ifnmujournal.com)
  • Japanese Journal of Cancer and Chemotherapy. (elsevier.com)
  • Pemetrexed is a chemotherapy drug that is manufactured and marketed by Eli Lilly and Company under the brand name Alimta. (drugbank.com)
  • [7] Similar to nitrogen mustards, cisplatin is used frequently in chemotherapy treatment - especially for testicular and ovarian cancers. (mdwiki.org)
  • Mitomycin C (MMC) is from a class of antibiotics that are used broadly in chemotherapy, often with gastrointestinal related cancers. (mdwiki.org)
  • Giving low dose of chemotherapy before a donor peripheral blood stem cell transplant helps stop the growth of cancer cells. (checkorphan.org)
  • What we have compiled below are actual human studies showing how natural compounds can be used either alone or in conjunction with chemotherapy and which may prevent cancer, may enhance the quality of life or may increase survival time in cancer patients. (compassionateacupuncture.com)
  • The results suggest that subgroups of cancer patients might be responsive to Ganopoly in combination with chemotherapy/radiotherapy. (compassionateacupuncture.com)
  • Chinese medicinal herbs to treat the side-effects of chemotherapy in breast cancer patients. (compassionateacupuncture.com)
  • Leucovorin is a reduced form of folic acid, which is readily converted to other reduced folic acid derivatives (e.g., tetrahydrofolate). (nursingschoolstudyaids.com)
  • The drug is also used to counteract the toxicity associated with an overdose of folic acid antagonists, and it is also administered to patients who have metastatic colorectal cancer in combination with fluorouracil. (mednews365.com)
  • Injectable forms are also indicated for use in the treatment of megaloblastic anemias due to folic acid deficiency when oral therapy is not feasible and for use in combination with 5-fluorouracil to prolong survival in the palliative treatment of patients with advanced colorectal cancer. (drugbank.com)
  • Also used in combination with 5-fluorouracil to prolong survival in the palliative treatment of patients with advanced colorectal cancer. (drugbank.com)
  • Farber hypothesized that leukemia could be treated with a folate antagonist, a drug with a molecular structure similar to that of folic acid which would bind to the folate receptors in cancer cells, preventing them from receiving the folic acid they needed. (wikipedia.org)
  • Pemetrexed is transported into murine and human leukemia cells by the RFC, with transport kinetics similar to MTX, and binds to FR-α with an affinity similar to that of folic acid (6, 7) . (aacrjournals.org)
  • As the time interval between antifolate administration (e.g., methotrexate) and leucovorin rescue increases, leucovorin's effectiveness in counteracting hematologic toxicity decreases. (nih.gov)
  • It is useful as an antidote to drugs which act as folic acid antagonists. (drugbank.com)
  • Leucovorin is used principally as an antidote to folic acid antagonists. (targetmol.com)
  • In reinforcing the recall, the US Food and Drug Administration warned that using an injectable medicine that has foreign particulates is not sterile and could have serious health risks. (mednews365.com)
  • There is good evidence that injectable methotrexate is more reliably effective than tablets, particularly as the dose increases. (canrio.ca)
  • Variable effects with phenobarbital, valproic acid, and valproate sodium. (clinicaladvisor.com)
  • The BNF was recently published an article in the European chosen because it is a complete, independent, Journal of Clinical Pharmacology which docu- and practice-oriented source of information and is ments the variability of written drug information in widely used by professionals around the world, and within countries concerning the indications, being easy to obtain and inexpensive. (who.int)
  • based on indications, side effects, and cautions for each country and drug. (who.int)
  • The present review has proposed hypotheses such as combining PPAR (α/γ) agonist with noradrenaline dopamine reuptake inhibitor, gap junction channel modulator/hemichannel inhibitor with N-methyl-D-aspartate receptor antagonist like ketamine, ω-3 fatty acids derivatives like resolvin with tricyclic antidepressant like amineptine, RAAS-modifying drugs with serotonin reuptake inhibitors such as fluoxetine, ceramide synthase inhibitor/acid sphingomyelinase inhibitor with doxepin, and HPA axis-modifying drugs with bupropion. (journaltocs.ac.uk)
  • It is the role of vitamin B-12 in the reduction of folic acid derivatives that results in the megaloblastic changes seen clinically. (medscape.com)
  • Leucovorin is one of several active, chemically reduced derivatives of folic acid. (drugbank.com)
  • 5. Check history for allergies and potential drug interactions before administering a newly ordered drug. (pharmapdf.com)
  • Because it does not require reduction by dihydrofolate reductase as does folic acid, leucovorin is not affected by blockage of this enzyme by folic acid antagonists (dihydrofolate reductase inhibitors). (nursingschoolstudyaids.com)
  • As folate analogs, leucovorin and levoleucovorin are both used to counteract the toxic effects of folic acid antagonists, such as methotrexate, which act by inhibiting the enzyme dihydrofolate reductase (DHFR). (drugbank.com)
  • Administration of leucovorin can counteract the therapeutic and toxic effects of folic acid antagonists such as methotrexate, which act by inhibiting dihydrofolate reductase. (drugbank.com)
  • Pyrimethamine is a competitive inhibitor of dihydrofolate reductase (DHFR), used as an antimalarial drug. (targetmol.com)
  • Counteracts the effects of folic acid antagonists such as methotrexate , which acts by inhibiting dihydrofolate reductase. (hemonc.org)
  • These drugs competitively inhibit dihydrofolate reductase and block the synthesis of tetrahydrofolate, a cofactor required in purine biosynthesis and other metabolic functions. (molcells.org)
  • Folic acid's primary function in the body is as a cofactor to various methyltransferases involved in serine, methionine, thymidine and purine biosynthesis. (targetmol.com)
  • Nucleic acid vaccines: Recently, nucleic acid chains, e.G., purine and pyrimidine antagonists: Methotrexate: This folic acid antagonists and inhibit catabolic processes. (ceu.edu)
  • Pemetrexed is a parenterally administered folate antagonist and antineoplastic agent, used in the treatment of non-small cell lung cancer and malignant mesotheli. (targetmol.com)
  • Previous studies have investigated the conjugation of drugs to various soluble polymers such as polysaccharides, dextran, peptides, amino acids, and polyethylene glycols (PEGs). (jrpsjournal.com)
  • Glutamic and aspartic acids are well-known amino acids used to prepare the biodegradable and pH-responsive carrier systems. (jrpsjournal.com)
  • Glutamic acid, which is a non-essential proteinogenic amino acid, has a prominent role in amino acid metabolism of organisms. (jrpsjournal.com)
  • [8] It also is a nitrogen donor in nucleotide synthesis, improving the essential amino acid uptake and TOR kinase activation. (jrpsjournal.com)
  • This important pathway, which is required for de novo synthesis of nucleic acids and amino acids, is disrupted when high-dose methotrexate is used for cancer therapy. (drugbank.com)
  • and ii) a heavy chain comprising amino acid residues 20 to 466 of SEQ ID NO:31. (gc.ca)
  • In initial Phase I studies, a new generation antifolate pemetrexed, ALIMTA, LY-231514, ( N -{4-[2-(2-amino-3,4-dihydro-4-oxo-7 H -pyrrolo[2,3- d ]pyrimidin-5-yl)ethyl]benzoyl}- l -glutamic acid) showed activity in a variety of neoplastic diseases and, in combination with cisplatin, was active in mesothelioma (1, 2) . (aacrjournals.org)
  • Biotin is necessary for cell growth, the production of fatty acids, and the metabolism of fats and amino acids. (anticancertools.ca)
  • in which one is unable to break down the amino acid phenylalanine) often develop skin conditions such as eczema and seborrheic dermatitis in areas of the body other than the scalp. (anticancertools.ca)
  • Nitrous acid is formed as a byproduct in the stomach from dietary sources of nitrites and can lead to crosslink lesions in DNA through the conversion of amino groups in DNA to carbonyls. (mdwiki.org)
  • However, associations of metabolomic measures with urinary α-TLHQ were markedly different from those with both serum α-TOH and urinary α-CEHC, with negative and small-to-null relations to most very-low-density lipoproteins and amino acids. (nutrition-evidence.com)
  • Leucovorin is a folate analog used to treat the toxic effects of methotrexate and other folate antagonists, to treat megaloblastic anemia, and to provide palliative treatment of colorectal cancer. (drugbank.com)
  • For the treatment of colorectal cancer. (pdr.net)
  • NOTE: Both bevacizumab and irinotecan are FDA approved for the treatment of metastatic colorectal cancer in combination with leucovorin and 5-FU. (pdr.net)
  • The 2 most common causes of megaloblastic anemia are vitamin B-12 (cobalamin) deficiency and folic acid deficiency. (medscape.com)
  • This results in a deficiency of coenzymes and a resultant buildup of toxic substances that are responsible for numerous adverse side effects associated with methotrexate therapy. (drugbank.com)
  • Used to diminish the toxicity and counteract the effects of impaired methotrexate elimination and of inadvertent overdosages of folic acid antagonists, and to treat megaloblastic anemias due to folic acid deficiency. (drugbank.com)
  • One example of such a relationship that takes place in microbial ecology is between the microbial species Lactobacillus casei … Low doses of methotrexate can deplete folate stores and cause side-effects that are similar to folate deficiency. (miasta2050.pl)
  • Folic acid may be inhibited by taking this medication, causing a deficiency that could also create a deficiency of vitamin B12. (naturalnews.com)
  • Folic acid deficiency causes some red blood cells to be larger than normal. (ahealthyme.com)
  • Healthy people rarely have folic acid deficiency. (ahealthyme.com)
  • If you have a folic acid deficiency, you have a reduced number of white blood cells. (ahealthyme.com)
  • High doses of folic acid can hide pernicious anemia, which is due to vitamin B-12 deficiency. (ahealthyme.com)
  • Your healthcare provider may watch you closely if you have vitamin B-12 deficiency and you also need folic acid supplements. (ahealthyme.com)
  • Patients with palmoplantar pustulosis had metabolic derangements of glucose and fatty acids as well as immune dysfunction derived from biotin deficiency, which led to abnormal manifestations of skin, bone and other tissues and organs. (anticancertools.ca)
  • The novel targets considered in the recent research related to the treatment of depression include connexins, peroxisome proliferator activated receptor (PPAR), ω-3 fatty acids, ceramides, and renin-angiotensin-aldosterone system (RAAS). (journaltocs.ac.uk)
  • Cod liver oil (omega-3 Fatty Acids) reduces the need for NSAIDs in patients with rheumatoid arthritis. (greenmedinfo.com)
  • n-3) fatty acids and cancer therapy. (compassionateacupuncture.com)
  • Leucovorin rescues bone marrow and gastrointestinal cells from methotrexate but has no apparent effect on pre-existing methotrexate nephrotoxicity. (nursingschoolstudyaids.com)
  • Unexpectedly severe (sometimes fatal) bone marrow suppression, aplastic anaemia, and gastrointestinal toxicity have been reported with concomitant administration of methotrexate (usually in high dosage) along with some non-steroidal anti-inflammatory drugs (NSAIDs). (ciplamed.com)
  • Methotrexate can cause gastrointestinal upset, fatigue, or even flu-like symptoms in some people. (canrio.ca)
  • Folinic Acid (also known as 5-formyl tetrahydrofolic acid or leucovorin) is the 5-formyl derivative of tetrahydrofolic acid, a necessary co-factor in the body. (drugbank.com)
  • The biologically active compound of the mixture is the (-)-l-isomer, known as Citrovorum factor or (-)-folinic acid. (drugbank.com)
  • Folinic Acid, a reduced folic acid, is used in combination with other chemotherapeutics. (targetmol.com)
  • Class/mechanism: Folic acid analog that is the pharmacologically active isomer of 5-formyl tetrahydrofolic acid (racemic d,l Folinic acid (Leucovorin) ). (hemonc.org)
  • They also performed early research into the clinical efficacy and toxicity of folic acid antagonists, documenting responses in 93 patients with various forms of incurable blood cancers and solid tumors. (medscape.com)
  • Journal of Cancer Research and Clinical Oncology. (ifnmujournal.com)
  • Anyone considering the use of antiepileptic drugs must balance this risk of suicide with the clinical need for the antiepileptic drug. (medicinenet.com)
  • As part of our mission to eliminate cancer, MD Anderson researchers conduct hundreds of clinical trials to test new treatments for both common and rare cancers. (mdanderson.org)
  • Clinical trials of lonidamine in combination with other anticancer agents for a variety of cancers has begun. (cloudfront.net)
  • Viscum album L. extracts in breast and gynaecological cancers: a systematic review of clinical and preclinical research. (compassionateacupuncture.com)
  • There are three general classes of drugs commonly used in the treatment of rheumatoid arthritis: non-steroidal anti-inflammatory agents (NSAIDs), corticosteroids, and disease modifying anti-rheumatic drugs (DMARDs). (hopkinsarthritis.org)
  • A summary table of how to monitor drug treatment in rheumatoid arthritis is included. (hopkinsarthritis.org)
  • It is important to note however that these drugs alone do not change the course of the disease of rheumatoid arthritis or prevent joint destruction. (hopkinsarthritis.org)
  • Methotrexate should be used only in life-threatening neoplastic diseases or in patients with psoriasis or rheumatoid arthritis (ra) with severe, recalcitrant, disabling disease, which is not adequately responsive to other forms of therapy. (ciplamed.com)
  • Deaths have been reported with the use of methotrexate in the treatment of malignancy, psoriasis, and rheumatoid arthritis. (ciplamed.com)
  • Pregnant women with psoriasis or rheumatoid arthritis should not receive methotrexate. (ciplamed.com)
  • Methotrexate is considered the current gold standard first line treatment for rheumatoid arthritis because of its effectiveness and side effect profile. (canrio.ca)
  • This double-blind, active-controlled, randomized, multinational study evaluated the efficacy, safety, pharmacokinetics (PK), and immunogenicity of PF-06438179/GP1111 (IxifiTM/Zessly®), an infliximab biosimilar, vs infliximab (Remicade®) reference product sourced from the European Union (infliximab-EU) in biologic-naïve patients with moderate to severe active rheumatoid arthritis (RA) despite methotrexate therapy. (biomedcentral.com)
  • Infliximab, in combination with methotrexate (MTX), is indicated for the reduction of signs and symptoms of moderate to severe active rheumatoid arthritis (RA) [ 1 , 2 ]. (biomedcentral.com)
  • Bee venom has both a synergist and drug sparing effect when combined with drugs in the treatment of rheumatoid arthritis. (greenmedinfo.com)
  • Most patients who developed these infections were taking concomitant immunosuppressants such as methotrexate or corticosteroids. (rxlist.com)
  • It can be used as a rescue drug after a patient receives a high dose of methotrexate therapy, particularly in patients suffering from osteosarcoma. (mednews365.com)
  • Methotrexate is a folate analog metabolic inhibitor with immunosuppressant and antineoplastic properties. (targetmol.com)
  • Pemetrexed is a folate analog used to treat mesothelioma and non-small cell lung cancer. (drugbank.com)
  • When Jane Cooke Wright, MD, entered the medical profession in 1945, the notion that toxic drugs could target tumors struck many physicians and patients as outlandish. (medscape.com)
  • I. To compare event-free survival (EFS) between patients with upper tract urothelial cancer (UTUC) randomized to neoadjuvant accelerated methotrexate, vinblastine, adriamycin, cisplatin (aMVAC) alone or in combination with MEDI4736 (durvalumab). (clinicaltrials.gov)
  • All patients) V. To evaluate cancer-specific survival of patients in each arm separately. (clinicaltrials.gov)
  • Patients also receive methotrexate IV over 2-3 minutes, vinblastine sulfate IV, doxorubicin IV, cisplatin IV over at least 2 hours on day 1. (clinicaltrials.gov)
  • Li took the job primarily to avoid being drafted into the US military during the Korean War, but became obsessed with finding a cancer cure after watching patients die in terrible pain from choriocarcinoma, a cancer of the placenta. (wikipedia.org)
  • Although they were unable to demonstrate any improvement in patient health, the team made one important finding: When patients were being treated with methotrexate, urine levels of the hormone human chorionic gonadotropin (hCG) dropped steadily. (wikipedia.org)
  • During his work with these three patients Li tried varying the amount of methotrexate given to the patients and the frequency of the doses. (wikipedia.org)
  • Li and his colleagues found that methotrexate eliminated the visible tumors in patients whose choriocarcinoma had metastasized. (wikipedia.org)
  • Those patients whose methotrexate treatment was stopped once the visible tumors disappeared inevitably relapsed, while the patients who continued to be treated until their hCG levels returned to normal were cured. (wikipedia.org)
  • we are are delivering hope to millions of cancer patients globally with best quality medicines selected by our team of experts from leading manufacturers with cGMP, WHO cerified Approved plants. (onlinemedicinesindia.com)
  • Medical centers that might expect to receive large numbers of patients in a single incident should stock larger amounts of antidotes or have an effective and efficient drug sharing/transfer procedure in place to rapidly obtain additional antidotal supplies. (calpoison.org)
  • Fortunately in the last few years, a shift in strategy toward the earlier institution of disease modifying drugs and the availability of new classes of medications have greatly improved the outcomes that can be expected by most patients. (hopkinsarthritis.org)
  • In the pediatric UC trial, 58 patients were evaluated for antibodies to infliximab using the EIA as well as the drug-tolerant ECLIA. (medlibrary.org)
  • While EIA-positive patients generally had undetectable trough infliximab concentrations, ECLIA-positive patients could have detectable trough concentrations of infliximab because the ECLIA assay is more sensitive and drug-tolerant. (medlibrary.org)
  • Effect of long-term gastric acid suppressive therapy on serum vitamin B12 levels in patients with Zollinger-Ellison syndrome. (naturalnews.com)
  • Treatment with antidiarrheal agents such as loperamide or diphenoxylate/atropine should generally be avoided in patients with active inflammation, as these drugs can precipitate toxic megacolon in individuals with significant colonic inflammation. (medscape.com)
  • Methotrexate elimination is reduced in patients with impaired renal function, ascites or pleural effusions. (ciplamed.com)
  • Such patients require especially careful monitoring for toxicity, and require dose reduction or, in some cases, discontinuation of methotrexate administration. (ciplamed.com)
  • Malignant lymphomas, which may regress following withdrawal of methotrexate, may occur in patients receiving low-dose methotrexate and, thus, may not require cytotoxic treatment. (ciplamed.com)
  • Like other cytotoxic drugs, methotrexate may induce 'tumour lysis syndrome' in patients with rapidly growing tumours. (ciplamed.com)
  • Your gift will help support our mission to end cancer and make a difference in the lives of our patients. (mdanderson.org)
  • Most patients start to feel the positive effects of methotrexate at 4-8 weeks, with maximum benefit at 3-6 months. (canrio.ca)
  • PF-06438179/GP1111 and infliximab-EU demonstrated similar efficacy, safety, immunogenicity, and PK with or without dose escalation in patients with moderate to severe active RA on background methotrexate. (biomedcentral.com)
  • In one of the studies, involving 570 adults with acute myeloid leukaemia (a blood cancer) or myelodysplastic syndromes (conditions in which large numbers of abnormal blood cells are produced), 64% of patients given treosulfan (with fludarabine) had a successful transplant and were alive and disease-free after 2 years, compared with 51% of patients given busulfan (with fludarabine). (mdwiki.org)
  • Sequencing of genes of drug response in tumor DNA and implications for precision medicine in cancer patients. (cdc.gov)
  • We evaluated genotype concordance between tumor DNA and genomic DNA from blood and catalogued functional effects of somatic mutations in 21 drug response genes in 752 solid tumor patients. (cdc.gov)
  • Somatic mutations were observed in all 21 drug response genes, and 44% of patients had at least one somatic mutation in these genes. (cdc.gov)
  • Effects of water-soluble Ganoderma lucidum polysaccharides on the immune functions of patients with advanced lung cancer. (compassionateacupuncture.com)
  • This open-label study aimed to evaluate the effects of water-soluble G. lucidum polysaccharides (Ganopoly , Encore International Corp., Auckland, New Zealand) on immune functions in patients with advanced lung cancer. (compassionateacupuncture.com)
  • However, some cancer patients demonstrated markedly modulated immune functions. (compassionateacupuncture.com)
  • Association of ginseng use with survival and quality of life among breast cancer patients. (compassionateacupuncture.com)
  • Dietary intake and serum levels of iron in relation to oxidative stress in breast cancer patients. (compassionateacupuncture.com)
  • Because these drugs target specific receptor sites, they are the least toxic of all cancer drugs. (nursingschoolstudyaids.com)
  • Tamoxifen citrate is the only selective estrogen receptor modulator that acts via estrogen-receptor-independent pathways in breast cancer. (objectifjeux.net)
  • Effect of antacid and H2 receptor antagonists on the intestinal absorption of folic acid. (naturalnews.com)
  • The present invention further provides methods for treating various cancers and chronic infections with stable formulations of antibodies against human programmed death receptor PD-1, or antigen binding fragments thereof. (gc.ca)
  • Levocetirizine is an H 1 -receptor antagonist, an active enantiomer of cetirizine. (medscape.com)
  • They are known to work as competitive GABAa receptor antagonists with powerful convulsant activity. (nextwellpharmaceutical.com)
  • Leucovorin is a mixture of the diastereoisomers of the 5-formyl derivative of tetrahydrofolic acid (THF). (drugbank.com)
  • Leucovorin is a racemic mixture of the diastereoisomers of the 5-formyl derivative of tetrahydrofolic acid. (nih.gov)
  • The body converts folic acid to tetrahydrofolic acid. (ahealthyme.com)
  • Other less common causes include the use of metabolic inhibitors such as methotrexate and 6-mercaptopurine and certain rare inborn errors such as thiamine-responsive megaloblastic anemia,[2, 3] Lesch-Nyhan syndrome, and hereditary orotic aciduria (see Etiology). (medscape.com)
  • In the early 1950s, Jane C. Wright used methotrexate, a less toxic drug of the same type, to treat breast cancer. (wikipedia.org)
  • Aspirin is the oldest drug of the non-steroidal class, but because of its high rate of GI toxicity, a narrow window between toxic and anti-inflammatory serum levels, and the inconvenience of multiple daily doses, aspirin's use as the initial choice of drug therapy has largely been replaced by other NSAIDs. (hopkinsarthritis.org)
  • The combination of limited perfusion to and from the tumor, and the metabolic activities of the cancer cells themselves, contributes to a harsh and toxic environment. (molcells.org)
  • 2. Pharmacodynamics - mechanism by which drugs produce changes in body tissue. (pharmapdf.com)
  • The name antifolate usually refers to drugs whose folate antagonism is intentional. (miasta2050.pl)
  • Cabazitaxel injection is used along with prednisone to treat prostate cancer (cancer of a male reproductive organ) that has already been treated with other medications. (onlinemedicinesindia.com)
  • Bdsure 11.25mg Injection is used in the treatment of prostate cancer. (onlinemedicinesindia.com)
  • Oncomide 1000mg Injection is used in the treatment of different kinds of cancers. (onlinemedicinesindia.com)
  • Consumers should also contact their doctor or health care professional if they believe they have taken this drug and experienced any problem related to the injection. (mednews365.com)
  • What is the difference between taking methotrexate tablets versus the injection? (canrio.ca)
  • Eribulin Mesylate Injection is used in the treatment of breast cancer. (mediexim.com)
  • Clofarabine Injection is used to treat children, teenagers and young adults with a type of blood cancer called acute lymphoblastic leukemia (ALL). (mediexim.com)
  • Prominent & Leading Exporter from Nagpur, we offer jakavi 15 mg, hydroxyurea capsules, fondaflo 2.5 injection, veltam tamsulosin tablet, siroboon 1 mg and methotrexate. (shreepharmaexport.com)
  • Lonidamine is a derivative of indazole-3-carboxylic acid , which for a long time, has been known to inhibit aerobic glycolysis in cancer cells. (cloudfront.net)
  • This is due to its proven ability to inhibit energy metabolism in cancer cells, and to enhance the activity of anticancer agents. (cloudfront.net)
  • Pemetrexed is used to treat non-squamous non-small cell lung cancer, or malignant pleural mesothelioma (a form of lung cancer associated with exposure to asbestos). (onlinemedicinesindia.com)
  • Polyglutamated metabolites have an increased intracellular half-life resulting in prolonged drug action in malignant cells. (drugbank.com)
  • Antagonist (disambiguation) Antifolates act specifically during DNA and RNA synthesis, and thus are cytotoxic during the S-phase of the cell cycle. (miasta2050.pl)
  • During the 1980s, Brandes was researching the breast cancer drug tamoxifen and looking for a substance to bind to 'antiestrogen binding sites' within cells. (lornebrandes.com)
  • Gamma linolenic acid with tamoxifen as primary therapy in breast cancer. (compassionateacupuncture.com)
  • Tamoxifen, soy, and lifestyle factors in Asian American women with breast cancer. (compassionateacupuncture.com)
  • Effect of Coenzyme Q(10), Riboflavin and Niacin on Tamoxifen treated postmenopausal breast cancer women with special reference to blood chemistry profiles. (compassionateacupuncture.com)
  • CC exists as a racemic mixture of shorter acting enclomiphene purely anti estrogenic effects and longer acting zuclomiphene both estrogen agonist and antagonist effects and exhibits a serum half life of approximately 5 days. (aeroenginecraft.com)
  • Methotrexate is a folic acid antagonist that is widely used as an immunosuppressant and chemotherapeutic agent. (targetmol.com)
  • Cancer research must be focused on finding new and efficient chemotherapeutic regimens that can relieve severe side effects caused by conventional treatments. (ifnmujournal.com)
  • Glutamic acid is converted to glutamine in the body by the reaction of this acid and ammonia and the enzyme glutamine synthase. (jrpsjournal.com)
  • For the treatment of osteosarcoma (after high dose methotrexate therapy). (drugbank.com)
  • Desloratadine is a long-acting tricyclic histamine antagonist that is selective for H 1 receptors. (medscape.com)
  • Alfuzosin is a selective antagonist of post-synaptic alpha1-adrenoreceptors, which are located in the prostate, bladder base, bladder neck, prostatic capsule, and prostatic urethra. (medicationjunction.com)
  • After consultation with pharmacologist Paul Condit, Li administered a single 10 mg dose of methotrexate. (wikipedia.org)
  • Concluding that the 50 mg dose of methotrexate had provided some temporary benefits, Li decided to try four daily doses of 25 mg. (wikipedia.org)
  • Severe, occasionally fatal, skin reactions have been reported following single o rmultiple doses of methotrexate. (ciplamed.com)
  • Antifolates are a class of antimetabolite medications that antagonise (that is, block) the actions of folic acid (vitamin B9). (targetmol.com)
  • Antifolates can thus target cancer cells based on their highly proliferative nature and requirement for nucleic acids. (molcells.org)
  • Antifolates and other strategies that also exploit the rapid proliferation of cells, for example DNA- damaging agents such as the platins, have proven to be effective tools against cancer. (molcells.org)
  • Methotrexate causes hepatotoxicity, fibrosis and cirrhosis, but generally only after prolonged use. (ciplamed.com)
  • Methotrexate (MTX) is used as a folic acid antagonist in the treatment of many human cancers. (jrpsjournal.com)
  • Between 1953 and 1955, while still at Sloan Kettering, Li and his colleagues experimented with using methotrexate as a cancer treatment. (wikipedia.org)
  • Mitomycin is used in combination with other medications to treat cancer of the stomach or pancreas that has spread to other parts of the body and has not improved or worsened after treatment with other medications, surgery, or radiation therapy. (onlinemedicinesindia.com)
  • Antiandrogens - treatment of metastatic prostate cancer. (nursingschoolstudyaids.com)
  • Progestins - such as medroxyprogesterone acetate (Depo-Provera) and megestrol (Megace) treatment of advanced endometrial cancer. (nursingschoolstudyaids.com)
  • Monitoring of the serum methotrexate concentration is essential in determining the optimal dose and duration of treatment with leucovorin. (nih.gov)
  • There is no evidence that this drug is used in any other way paxlovid price pharmacy pleadingly (ie, for the prevention or treatment of parasitic infections other than on farm animals in the united states and a single case of ivermectin treatment being administered to human beings from guatemala to mexico who had been bitten by a dog that had been infected by a parasite other than. (objectifjeux.net)
  • Calcium N5-methyltetrahydrofolate is the calcium salt of levomefolic acid, which has been proposed for treatment of cardiovascular disease and advanced cancers s. (targetmol.com)
  • Cancer is a leading cause of millions of deaths worldwide and, despite the improvements in molecular biology, issues concerning how to advance cancer treatment are still relevant. (ifnmujournal.com)
  • Antitumor drugs and radiation have been used as the treatment of choice in some cancer cases, except for the choice of surgery in case of solid tumors. (ifnmujournal.com)
  • Additionally, gene treatment and nanotechnology are promising methods for cancer treatment as well. (ifnmujournal.com)
  • 2]. While the role of folate as a cancer treatment is well established, its long-term effectiveness is diminished by cellular response. (miasta2050.pl)
  • Discontinue methotrexate first and, if the lymphoma does not regress, appropriate treatment should be instituted. (ciplamed.com)
  • While methotrexate is used in the treatment of cancer, its frequency and dosing is much higher. (canrio.ca)
  • When used in the treatment of a rheumatic condition, methotrexate is considered to be a relatively low dose and would not be used that way to treat cancer. (canrio.ca)
  • If methotrexate is the gold standard treatment, why am I on more than just methotrexate? (canrio.ca)
  • For adjuvant treatment of high-risk stage II or stage III rectal cancer in combination with radiation therapy. (pdr.net)
  • Whether these are long-term treatment with dopamine antagonists/partial agonists caused by antidepressants has been the vassal exposed to of considerable (Plain 7). (lovina.ps)
  • Used in the treatment of cancer. (azurewebsites.net)
  • Serum drug concentrations were similar between arms at each time point during the initial 30-week treatment period. (biomedcentral.com)
  • It clearly implies that whether it's animal venom or drugs for the treatment, the toxicity will be determined by the amount of used substance. (springeropen.com)
  • The donated stem cells may replace the patient's immune cells and help destroy any remaining cancer cells (graft-versus-cancer effects). (checkorphan.org)
  • Cervical vertebrae 1,2, …?Ca: Calcium?Ca: Cancer?Ca: Carcinoma?Ca: Cardiac arrest?Ca: Coronary artery?CA-125: A tumor marker for ovarian cancer?CAB: Cellulose acetate butyrate?CABG: Coronary artery bypass graft?CACI: Computer-Assisted Continuous Infusion?CAD: Coronary artery disease?CAG: ?CAH: Chronic active hepatitis?CAH: Congenital adrenal hyperplasia?calid. (kuwaitpharmacy.com)