A species of AVIPOXVIRUS, subfamily CHORDOPOXVIRINAE. Canarypox virus vectors are used in vaccine and immunotherapy research.
A genus of the family POXVIRIDAE, subfamily CHORDOPOXVIRINAE, comprising bird poxviruses. The type species is FOWLPOX VIRUS. Transmission is mechanical by ARTHROPODS.
Vaccines or candidate vaccines containing inactivated HIV or some of its component antigens and designed to prevent or treat AIDS. Some vaccines containing antigens are recombinantly produced.
Small synthetic peptides that mimic surface antigens of pathogens and are immunogenic, or vaccines manufactured with the aid of recombinant DNA techniques. The latter vaccines may also be whole viruses whose nucleic acids have been modified.
Suspensions of attenuated or killed viruses administered for the prevention or treatment of infectious viral disease.
DNA molecules capable of autonomous replication within a host cell and into which other DNA sequences can be inserted and thus amplified. Many are derived from PLASMIDS; BACTERIOPHAGES; or VIRUSES. They are used for transporting foreign genes into recipient cells. Genetic vectors possess a functional replicator site and contain GENETIC MARKERS to facilitate their selective recognition.
Immunized T-lymphocytes which can directly destroy appropriate target cells. These cytotoxic lymphocytes may be generated in vitro in mixed lymphocyte cultures (MLC), in vivo during a graft-versus-host (GVH) reaction, or after immunization with an allograft, tumor cell or virally transformed or chemically modified target cell. The lytic phenomenon is sometimes referred to as cell-mediated lympholysis (CML). These CD8-positive cells are distinct from NATURAL KILLER CELLS and NATURAL KILLER T-CELLS. There are two effector phenotypes: TC1 and TC2.
The type species of ORTHOPOXVIRUS, related to COWPOX VIRUS, but whose true origin is unknown. It has been used as a live vaccine against SMALLPOX. It is also used as a vector for inserting foreign DNA into animals. Rabbitpox virus is a subspecies of VACCINIA VIRUS.

Purification of Ag-specific T lymphocytes after direct peripheral blood mononuclear cell stimulation followed by CD25 selection. I. Application to CD4(+) or CD8(+) cytomegalovirus phosphoprotein pp65 epitope determination. (1/35)

The two main constraints that currently limit a broader usage of T cell therapy against viruses are the delay required to obtain specific T cells and the safety of the selection procedure. In the present work we developed a generally applicable strategy that eliminates the need for APC for timing reasons, and the need for infectious viral strains for safety concerns. As a model, we used the selection of T lymphocytes specific for the immunodominant CMV phosphoprotein pp65. PBMC from healthy seropositive donors were first depleted of IL-2R alpha-chain CD25(+) cells and were then stimulated for 24-96 h with previously defined peptide Ags or with autologous PBMC infected with a canarypox viral vector encoding the total pp65 protein (ALVAC-pp65). Subsequent immunomagnetic purification of newly CD25-expressing cells allowed efficient recovery of T lymphocytes specific for the initial stimuli, i.e., for the already known immunodominant epitope corresponding to the peptides used as a model or for newly defined epitopes corresponding to peptides encoded by the transfected pp65 protein. Importantly, we demonstrated that direct PBMC stimulation allowed recovery not only of CD8(+) memory T lymphocytes, but also of the CD4(+) memory T cells, which are known to be crucial to ensure persistence of adoptively transferred immune memory. Finally, our analysis of pp65-specific T cells led to the identification of several new helper and cytotoxic epitopes. This work thus demonstrates the feasibility of isolating memory T lymphocytes specific for a clinically relevant protein without the need to prepare APC, to use infectious viral strains, or to identify immunodominant epitopes.  (+info)

Recombinant canarypox vaccine-elicited CTL specific for dominant and subdominant simian immunodeficiency virus epitopes in rhesus monkeys. (2/35)

Since virus-specific CTL play a central role in containing HIV replication, a candidate AIDS vaccine should generate virus-specific CTL responses. In this study, the ability of a recombinant canarypox virus expressing SIV Gag-Pol-Env (ALVAC/SIV gag-pol-env) was assessed for its ability to elicit both dominant and subdominant epitope-specific CTL responses in rhesus monkeys. Following a series of five immunizations, memory CTL responses specific for a dominant Gag epitope could be demonstrated in the peripheral blood of vaccinated monkeys. Memory CTL responses to a subdominant Pol epitope were undetectable in these animals. Following challenge with SIVmac251, the experimentally vaccinated animals developed high frequency CTL responses specific for the dominant Gag epitope that emerged in temporal association with the early containment of viral replication. Interestingly, the experimentally vaccinated, but not the control vaccinated animals, developed CTL responses to the subdominant Pol epitope that were detectable only after containment of early viremia. Thus, recombinant canarypox vaccination elicited low frequency, but durable memory CTL populations. The temporal association of the emergence of the dominant epitope-specific response with early viral containment following challenge suggests that this immune response played a role in the accelerated clearing of early viremia in these animals. The later emerging CTL response specific for the subdominant epitope may contribute to the control of viral replication in the setting of chronic infection.  (+info)

Expression of vaccinia E3L and K3L genes by a novel recombinant canarypox HIV vaccine vector enhances HIV-1 pseudovirion production and inhibits apoptosis in human cells. (3/35)

Poxviruses that are attenuated for growth in human cells provide a safe means of HIV antigen expression and are capable of eliciting HIV-specific immune responses, including CD8+ cytotoxic T-lymphocyte (CTL) responses. HIV-1 antigen expression in human cells by attenuated poxvirus vectors may be limited by interferon-mediated host defense mechanisms. To enhance HIV antigen expression in human cells, the vaccinia virus E3L and K3L genes were inserted into a canarypox vector that expresses HIV-1 Gag, Env, and a Nef/Pol polyepitope string. E3L and K3L markedly reduced the activation of the double-stranded RNA-dependent protein kinase, PKR, and led to a significant reduction in apoptosis in HeLa cells. Production and release of HIV-1 antigen in the form of pseudovirions was enhanced in both duration and magnitude by this vector modification. The addition of immunomodulatory genes to attenuated poxviruses represents a novel strategy for enhancing antigen production by live vector HIV vaccine candidates.  (+info)

Induction of p53-specific immune responses in colorectal cancer patients receiving a recombinant ALVAC-p53 candidate vaccine. (4/35)

PURPOSE: The tumor-associated auto-antigen p53 is commonly overexpressed in various types of human cancer, including colorectal cancer. Experiments in preclinical models have shown that it can serve as a target for T-cell-mediated tumor-eradication. The feasibility of a p53-specific therapeutic vaccination was investigated in cancer patients. EXPERIMENTAL DESIGN: A Phase I/II dose-escalation study was performed that evaluated the effect of a recombinant canarypoxvirus (ALVAC) vaccine encoding wild-type human p53 in 15 patients with advanced colorectal cancer. Each group of five patients received three i.v. doses of one-tenth of a dose, one-third of a dose, or 1 dose of the vaccine [1 dose = 1 x 10(7.5) cell culture infectious dosis (CCID)50]. RESULTS: Potent T-cell and IgG antibody responses against the vector component of the ALVAC vaccine were induced in the majority of the patients. Enzyme-linked immunosorbent-spot assay (ELISPOT) analysis of vaccine-induced immunity revealed the presence of IFN-gamma-secreting T cells against both ALVAC and p53, whereas no significant interleukin-4 responses were detected. Vaccine-mediated enhancement of p53-specific T-cell immunity was found in two patients in the highest-vaccine-dose group. CONCLUSIONS: This study demonstrated the feasibility, even in patients with advanced cancer, to elicit immune responses against the ubiquitously expressed tumor-associated auto-antigen p53. Our results form the basis for additional studies that will explore the antitumor capacity of p53 containing multivalent vaccines in cancer patients with limited tumor burden.  (+info)

Preparation of clinical-grade recombinant canarypox-human immunodeficiency virus vaccine-loaded human dendritic cells. (5/35)

Preclinical data are reported that support a human immunodeficiency virus (HIV) vaccine strategy using recombinant canarypox-HIV vectors (ALVAC-HIV) to load human dendritic cells (DCs) with HIV antigens. Clinical-grade DCs were infected with good manufacturing practice-grade ALVAC-HIV vaccine constructs. ALVAC infection, HIV gene expression, and DC viability and function were monitored by use of immunohistochemistry, flow cytometry, blastogenesis assays, antigen-specific interferon (IFN)-gamma enzyme-linked immunospot assay, and enzyme-linked immunosorbent assay protein detection. The vaccines infected both immature and mature DCs, and intracellular HIV-1 Gag protein was detected within hours. ALVAC-HIV induced DC maturation that was mediated by tumor necrosis factor-alpha and induced DC apoptosis that was directly related to the length of vaccine exposure. Of importance, the infected DCs remained functional in T cell stimulation assays and induced HIV antigen-specific CD8(+) T cell production of IFN-gamma from cells of HIV-1-infected individuals. These data support an ongoing HIV vaccine trial comparing conventional vaccine delivery routes with ex vivo vaccine-loaded autologous DCs for immunogenicity in HIV-1-uninfected volunteers.  (+info)

DNA immunization with hepatitis C virus (HCV) polycistronic genes or immunization by HCV DNA priming-recombinant canarypox virus boosting induces immune responses and protection from recombinant HCV-vaccinia virus infection in HLA-A2.1-transgenic mice. (6/35)

We studied immune responses to hepatitis C virus (HCV) genes delivered as DNA encoding the entire HCV protein coding genome in two polycistronic plasmids encoding HCV capsid-E1-E2-NS2-NS3 and HCV NS3-NS4-NS5 in HLA-A2.1-transgenic mice. Immune responses to HCV DNA prime and recombinant canarypox virus boost were also studied with the above constructs. At 8 weeks after a canarypox virus boost, the DNA prime/canarypox virus boosting regimen induced potent cellular immune responses to HCV structural and nonstructural proteins on target cells expressing the HLA-A2.1 allele. High frequencies of gamma interferon-secreting cells, as detected by enzyme-linked immunospot assay, were obtained in response to several endogenously expressed HCV proteins. We also observed cytotoxic-T-lymphocyte reactivity in response to endogenously expressed HCV proteins in fresh spleen cells without in vitro expansion. Upon challenge with a recombinant vaccinia virus expressing HCV proteins at 2 months postimmunization, the HCV DNA prime/canarypox virus-immunized mice showed a complete reduction in vaccinia virus titers compared to HCV DNA prime/boost- and mock-immunized controls. Immune responses were still detectable 4 months after canarypox virus boost in immunized mice. Interestingly, at 10 months postimmunization (8 months after canarypox virus boost), the protection in HCV DNA prime/boost-immunized mice against recombinant HCV-vaccinia virus challenge was higher than that observed in HCV DNA prime/canarypox virus boost-immunized mice.  (+info)

Induction of HLA-G-restricted human cytomegalovirus pp65 (UL83)-specific cytotoxic T lymphocytes in HLA-G transgenic mice. (7/35)

The non-classical major histocompatibility complex class I molecule HLA-G is expressed mainly by extravillous trophoblasts at the materno-foetal interface. HLA-G has been found to bind endogenously processed nonameric peptides but its function as a restriction element for a cytotoxic T cell response to viruses with tropism for trophoblastic cells has never been demonstrated. In this study, candidate viral peptides derived from human cytomegalovirus (HCMV) pp65 (UL83), which stabilized the HLA-G molecule on HLA-G-transfected T2 cells, were identified. The specific anti-pp65 cytotoxic T lymphocyte (CTL) response restricted by HLA-G in triple transgenic mice (HLA-G, human beta2m, human CD8alpha) was then investigated by injection of dendritic cells loaded with synthetic pp65-derived peptides or by infection with canarypox virus expressing pp65. Results showed that CTLs from HLA-G mice have the capacity to kill target cells either infected with recombinant vaccinia viruses expressing pp65 or loaded with specific pp65-derived peptides using HLA-G as an antigen-presenting molecule. It was also demonstrated that these HLA-G-restricted pp65-specific T cells are able to kill the human astrocytoma cell line U373, which was transfected with HLA-G and infected with HCMV. Moreover, using HLA-G tetramers refolded with a synthetic pp65-derived peptide, peptide-specific CD8(+) cells restricted by HLA-G have been detected in vivo. These findings provide the first evidence that HLA-G can select anti-HCMV-restricted CTLs in vivo, although the potency of this cytolytic response is limited (20-25 %). The weak HLA-G-restricted anti-HCMV response is probably due to HLA-G-mediated inhibitory signals on the development of an antiviral CTL response.  (+info)

Human immunodeficiency virus (HIV) seropositivity among uninfected HIV vaccine recipients. (8/35)

Since 1987, >10,000 individuals worldwide have received immunizations with human immunodeficiency virus (HIV) preventive vaccine constructs. Many constructs elicit antibodies detected by standard serologic tests (enzyme immunoassays, rapid tests, and Western blots) and result in vaccine recipients' serum being identified as reactive and indicative of HIV infection. To determine the frequency of vaccine-induced HIV antibody among uninfected HIV vaccine trial participants and to identify factors associated with these results, serum samples from HIV-uninfected participants from selected United States phase I/II HIV-1 vaccine trials were tested with 6 serologic screening tests. Reactive specimens were tested by use of Western blot. Overall, 490 serum specimens from 461 vaccine recipients were tested; 100 (20.4%) reacted on at least 1 serologic test, and 65 (13%) were determined to be positive by Western blot. Canarypox or vaccinia vaccine recipients' serum with or without HIV envelope glycoprotein (gp120 or gp160) boosts accounted for all positive Western blot results; no positive Western blot results were obtained from gp120 subunit recipients. The potential for vaccine recipients being misclassified as HIV infected increased with vaccine complexity.  (+info)

Phase Ib Trial of Intratumoral Injection of a Recombinant Canarypox Virus Encoding Human B7.1 (ALVAC-hB7.1) [ALVAC CEA] or a Combination of ALVAC-hB7.1 and a Recombinant Canarypox Virus Encoding Human Interleukin 12 (ALVAC-hIL-12) in Patients With Surgically Incurable Melanoma ...
In this thesis, two different vaccines were evaluated as adjuvant therapy for patients with colorectal cancer. The ability of the two candidate vaccines to generate antigen-specific cellular and humoral responses, respectively, was studied. The effectiveness of granulocyte colony stimulating factor (GM-CSF) as a cytokine adjuvant to augment the immune response was also examined.. The first vaccination strategy involved immunization with the recombinant tumor-associated protein, carcinoembryonic antigen (CEA). Recombinant CEA was administered at 4 different dose levels 7 times during one year. Peripheral blood samples were regularly analyzed during 36 months. This vaccination regimen induced a strong immunoglobulin 1 (IgG1) and IgG4 response, a moderate IgG2 response and a weak IgG3 response against CEA. GM-CSF markedly augmented the effect on IgG1 and IgG4 as well as the T cell response. In contrast, dose of rCEA had no or modest effect on induced immune responses. The response gradually ...
One of the earliest observations in the HIV epidemic was the demonstration of HIV infection at mucosal surfaces of cells in the genital tract. These data suggest that priming of immune defenses of viral infected cells may be an important component in the strategy of developing an effective HIV vaccine. Direct immunization of relevant mucosal surfaces with a vectored vaccine may stimulate mucosal immunity. The ALVAC-HIV vCP205 immunogen is constructed from a live recombinant canarypox vector that has a good safety profile in volunteers and should allow mucosal induction of immunity.. This randomized, double-blind trial evaluates the safety of and immune response to vaccination with ALVAC-HIV vCP205 given at 0, 1, 3, and 6 months. Patients are randomly assigned to 1 of 7 drug administration routes as follows:. Group A: Intramuscular Group B: Oral Group C: Intranasal Group D: Intrarectal Group E: Intravaginal Group F: Intranasal/intramuscular Group G: Intrarectal/intramuscular Twelve patients are ...
Mother-to-child transmission (MTCT) of HIV can be caused either by perinatal transmission of HIV or by breastfeeding, a common practice in poorer regions of the world. HIV preventive vaccines are currently under investigation as potential solutions to worldwide MTCT of HIV. This study will evaluate the safety and immunogenicity of an HIV-1 vaccine, ALVAC-HIV vCP1521, in infants born to HIV-1 infected mothers in Uganda. The vaccine is a preparation of a live attenuated recombinant canarypox virus, encoding HIV clades B and E envelope proteins. This study will be conducted at Mulago Hospital in Uganda.. Mothers will enroll in this study during their third trimesters of pregnancy. During screening, mothers will undergo medical history assessment, a physical exam, and blood collection. After delivery and prior to infant enrollment, mothers will have another physical exam; mothers and their infants will be accompanied home by a home visitor who will document contact information.. Infants will be ...
The shock-and-kill method combines latency reversal agents such as histone deacetylase inhibitors and toll-like receptor (TLR) agonists to induce HIV-1 transcription followed by ART, therapeutic vaccines, and/or broadly neutralizing antibodies (bNAbs) to decrease the latent reservoir. This process of reac-tivation is then followed by immunomodulation with agents such as therapeutic vaccines and/or bNAbs. The aim of therapeutic vaccines (such as the modi-fied vaccinia Ankara B and the recombinant canarypox virus) is to elicit an antigenic immune response to suppress viral replication in the absence ofART. Broadly neutralizing antibodies (such as VRC01 and 3BNC117) induce hostimmunity by targeting specific epitopes of HIV.. I am are also working on emerging strategies and evolving science regarding genetic modification have unlocked new approaches for HIV cure research. These approaches include using CRISPR and CAR T-cell technology. CRISPR enables DNA cleavage to occur prior to proviral ...
Viral vectors derived from different virus families, including poxvirus (canarypox virus vector ALVAC) and adenovirus (human Ad5 vector), have been widely used in vaccine development for a range of human diseases including HIV/AIDS. Less is known about the mechanisms underlying the host innate response to these vectors. Increasing evidence from clinical vaccine trials testing different viral vectors has suggested the importance of understanding basic elements of host-viral vector interactions. In this study, we investigated the innate interactions of APCs with two commonly used HIV vaccine vectors, ALVAC and Ad5, and identified AIM2 as an innate sensor for ALVAC, triggering strong inflammasome activation in both human and mouse APCs ...
موقعي كه زخم آبله در حنجره ايجاد مي شود، نفس كشيدن پرنده مشكل مي‌گردد. اغلب نفس نفس مي زند. اين حالت همزمان با ورود ويروس در خون ايجاد مي شود ولي اگر شدت ويروس و يا مقدار آن زياد باشد پرنده تلف مي‌گردد.. ترکیبات:. -ویال A (ویال جهت درمان موضعی):. Chloramphenicol…………… 4g. Excipient q.s. ………………100ml. -ویال B (ویال جهت درمان خوراکی):. Chloramphenicol…………….. 5,4g. Excipient q.s. ………………100ml. حیوانات هدف:. قناری، فنچ، طوطی، کبوتر و سایر پرندگان زینتی. میزان مصرف:. - تجویز در آب آشامیدنی ( ویال B) :. درمان می بایست در اولین زمان ممکن و از زمانی که احتمال بروز این بیماری وجود دارد، آغاز گردد.. میزان ...
IL-12 gene therapy may induce antitumor effects and potentially avoid the systemic toxicity associated with IL-12 protein immunotherapy (5, 27, 46-48). Prior studies have tested direct transfer of IL-12 cDNA into tumor, either using certain tumor cells engineered in vitro to release IL-12 (3, 30, 48) or using direct intratumoral injection of an adenovirus expressing IL-12 DNA (34) or a Canarypox virus expressing IL-12 vector (49). In addition, particle-mediated transfer of IL-12 cDNA was effectively used to treat murine tumors (2, 5, 28). All of these methods could inhibit tumor growth and induce antitumor immunity. Direct intratumoral injection of IL-12 cDNA, either naked or in complex with a liposome formulation, may provide an alternative, simpler, and safer gene transfer method compared with localized or systemic viral gene vector therapy. Liposomes have been used previously as a delivery agent incorporating nonviral plasmid vectors encoding other cytokine genes, including IL-2 and IL-4, to ...
Then the Thai government did an amazing thing: it acknowledged the importance of HIV, identified the source and instituted a prevention program, enforcing condom use in brothels. The impact was dramatic. Rates of infection declined precipitously and prevalence in sentinel populations fell. The epidemic was changing before a vaccine could be brought to the field. As incidence dropped, the trial had to become larger and compromises had to be introduced.. Initial plans called for optimizing both cellular and humoral HIV-specific responses using a prime-boost approach: a single prime (ALVAC-HIV, a CRF01-specific canarypox vaccine) was to be tested with three different boosts (subunit vaccines) in phase II trials from which the best regimen would be chosen for the Phase III trial. Shortly before the Phase II trials were complete, two of the manufacturers withdrew their products. The ALVAC-HIV + AIDSVAX B/E combination, the only regimen remaining, passed immunogenicity criteria for advancement to ...
Advanced ovarian cancer has the highest mortality rate among patients with cancers of the female reproductive system in the United States. Existing therapies fo...
Sanofi Pasteur announced the results of a Phase 3 trial with its HIV prime vaccine, ALVAC HIV (recombinant canarypox vCP1521) in combination with the booster AidsVax B/E (recombinant gp120 vaccine, from VaxGen).
A number of immune-based therapies continues to be developed to be able to boost or induce protective Compact disc8+ T cell responses to be able to control HIV replication. [10]. Sadly, these fresh vaccines and therapies usually do not deliver the expected success yet. For example, Autran et al. reported considerably elevated viral lots in chronically contaminated patients set alongside the placebo group after discontinuation of therapy pursuing immunization with vCP1452, the HIV-recombinant canarypox vaccine (ALVAC-HIV) [11]. Incredibly, individuals receiving more dosages from the vaccine rapidly required treatment resumption more. Analysis of the results immensely important how the vaccine didnt elicit protecting HIV-specific Compact disc8+ T cell reactions [12]. Moreover, primarily induction of triggered Compact disc4+ T cell reactions was proven in vaccines, which increased target cell availability and rendered patients even more vunerable to Volasertib distributor disease progression ...
Recommended Readings. Dhodapkar MV; Sznol M; Wang D, et al. 2010. Early development of CDX-1401, a novel vaccine targeting NY-ESO-1 to the dendritic cel receptor DEC-205. Journal of Immunotherapy. 33(8):895-896 Request Article from Markus Library. Wanialla CN; Faul EJ; Gomme EA, et al. 2010. Dendritic cells infected by recombinant rabies virus vaccine vector expressing HIV-1 Gag are immunogenic even in the presence of vector-specific immunity. Vaccine. 29(1):130-140. Fiorentini S; Giagulli C; Caccuri F, et al. 2010. HIV-1 matrix protein p17: a candidate antigen for therapeutic vaccines against AIDS. Pharmacology & Therapeutics. 128(3):433-444 Request Article from Markus Library.. De Groot A; Buhlmann J; Weber C, et al. 2010. De-Tolerization of anti-DEC-205 for HIV vaccine delivery. (abstract only) AIDS Research and Human Retroviruses. 26(10):A135-A136. Ahlers, JD; and IM Belyakov. 2009. Strategies for optimizing targeting and delivery of mucosal HIV vaccines. European Journal of Immunology. ...
SnuggleScents Essentials is a collection of aromas that are great for calming nerves and soothing nasal passages. The Essentials is tailored for new
The inability of current HIV vaccine regimens to generate a broad neutralizing antibody response against primary isolates leaves a major gap in our vaccine armamentarium. There is broad consensus that generation of such antibodies at high titer in vaccinated individuals in combination with vectors that elicit strong cellular immune responses is desirable. Immunogens that recreate the native, trimeric envelope glycoprotein structure on a lipid membrane have the potential to avoid generating undesirable antibodies directed against epitopes on gp120 that are not exposed on native virions. Whether antibodies raised by such membrane-bound primary isolate Env complexes can elicit strong neutralizing antibody responses remains to be determined.. The primary goal of this study was to define the ability of Gag-Env pseudovirions to generate antibodies capable of neutralizing primary HIV-1 isolates. Pseudovirions represent one means of presenting the Env glycoprotein complex in its native form. One of the ...
A chemiluminescence study showed that hepatitis B virus (HBV) and hepatitis C virus (HCV) DNA amplicons are capable of induced radiation when exposed to electromagnetic fields (EMFs) that range from...
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Clortermine (Voranil) was developed by Ciba in the 1960s[1] and is an anorectic drug of the amphetamine class.[2] It is the 2-chloro analogue of the better known appetite suppressant phentermine, and is the 2-chloro positional isomer of chlorphentermine. Clortermine produces very low rates of self-administration in animals similarly to chlorphentermine,[3] and as a result it likely does not act on dopamine. Instead, it may act as a serotonin and/or norepinephrine releasing agent.[citation needed] ...
Download the PDF version here. WHO WE ARE AND WHAT WE BELIEVE IN. We, 60 activists, advocates, and representatives from youth-led, youth-serving, and youth-allied organisations from diverse social movements in Asia and the Pacific region, came together in Bangkok to call for sustainable solutions to eradicate poverty and promote prosperity in the region through an intersectional analysis and participatory approach. A multidimensional perspective on poverty necessitates addressing not only economic concerns, but also environmental sustainability, as well as social dimensions-such as youth leadership and empowerment, gender equality, health, education, freedom from violence, right to information and technology, and human rights, including of young people and women who are poor, people of diverse sexual orientation and gender identities and expressions, people with all forms of disability, people living with and affected by HIV, ethnic minorities and indigenous peoples, people living in remote, ...
"Characterization of canarypox-like viruses infecting endemic birds in the Galápagos Islands". Journal of Wildlife Diseases. 41 ...
C22orf25 is also xenologous to T10 like proteins in the Fowlpox Virus and Canarypox Virus. The gene coding for C22orf25 is ... of the C22orf25 gene that are evolutionarily conserved in the Animalia and Plantae kingdoms as well as the Canarypox Virus ...
A strain of canarypox virus modified to carry feline interleukin-2 is used to treat cats with fibrosarcoma. Retroviruses are ... Tobacco mosaic virus (TMV) is the first virus to be discovered. Viral vectors based on tobacco mosaic virus include those of ... "EPAR summary for the public: Oncept IL-2 (Feline interleukin-2 recombinant canary pox virus) [EMA/151380/2013 EMEA/V/C/002562 ... Adeno-associated virus (AAV) is a small virus that infects humans and some other primate species. AAV is not currently known to ...
The ALVAC vector is an inert form of canarypox, a bird virus which cannot cause disease or replicate in humans. AIDSVAX B/E is ... Additionally, the vaccine regimen had no effect on the amount of virus in the blood of volunteers who became HIV-infected ... Dolgin, Elie (2009-09-24). "Vaccine protects against HIV virus". Nature News. doi:10.1038/news.2009.947. Rerks-Ngarm, S.; ... "Safety and Reactogenicity of Canarypox ALVAC-HIV (vCP1521) and HIV-1 gp120 AIDSVAX B/E Vaccination in an Efficacy Trial in ...
... is a cancer vaccine containing a canary pox virus (ALVAC) combined with the carcinoembryonic antigen (CEA) ...
"Immunization of Experimental Dogs With Salivary Proteins From Lutzomyia Longipalpis, Using DNA and Recombinant Canarypox Virus ...
His own research was on the canarypox virus, which he used in developing a chick embryo assay for the isolation and ... He brought back a set of viruses from the National Institute to begin the basis of research in Melbourne. When Burnet returned ... Following his productive work in London, the Rockefeller Institute agreed to fund a new virus research laboratory in Melbourne ... He examined the genetic control of virulence and demonstrated that the virus recombined at high frequency; this observation was ...
Another study to test whether the ALVAC recombinant canarypox virus could prime the immune system in cats was performed. This ... The specific virus that they get is H5N1, which is a subtype of Avian Influenza. In order to get the virus, cats need to be in ... Two of the main organs that the virus affects are the lungs and liver. The H5N1 virus has been found in China, Thailand, ... where three stray cats were found to be either dying or dead during the peak time of the virus outbreak. Because the virus ...
... canarypox virus MeSH B04.280.650.160.100.300 - fowlpox virus MeSH B04.280.650.160.150 - capripoxvirus MeSH B04.280.650.160. ... yellow fever virus MeSH B04.820.250.400 - gb virus a MeSH B04.820.250.405 - gb virus b MeSH B04.820.250.410 - GB virus C MeSH ... canarypox virus MeSH B04.909.204.783.160.100.300 - fowlpox virus MeSH B04.909.204.783.160.150 - capripoxvirus MeSH B04.909. ... yellow fever virus MeSH B04.909.777.310.400 - gb virus a MeSH B04.909.777.310.405 - gb virus b MeSH B04.909.777.310.410 - GB ...
... that uses genetic elements of several different HIV strains encapsulated in a canarypox virus vector. AIDSVAX B/E, moreover, ... effectively disabling the virus so that it could not bind to or invade susceptible cells. Then, another group, infected with a ... from a strain of the virus, MN, known at the time to infect people in the United States and Europe. The vaccine was designed to ...
... feline rhinotracheitis virus QI06AD06 Feline parapox virus QI06AD07 Feline leukaemia recombinant live canarypox virus QI06AD08 ... QI06AA01 Feline leukaemia virus QI06AA02 Feline panleukopenia virus/parvovirus QI06AA03 Rabies virus + feline rhinotracheitis ... live feline panleucopenia virus / parvovirus + live chlamydia + feline leukaemia recombinant live canarypox virus Empty group ... recombinant live canarypox virus QI06AE01 Chlamydia QI06AE02 Bordetella QI06AF01 Feline panleucopenia virus/parvovirus + feline ...
L03AX18 Cridanimod L03AX19 Dasiprotimut-T L03AX21 Elapegademase QL03AX90 Feline interleukin-2 recombinant canarypox virus ( ...
They were then boosted with a recombinant canarypox virus encoding all four antigens (ALVAC-4). Immunized monkeys developed ... They altered the DNA of cowpox virus by inserting a gene from other viruses (namely Herpes simplex virus, hepatitis B and ... The Sindbis virus and Semliki Forest virus have been used to build recombinant alphavirus replicons. Unlike conventional DNA ... activity of vaccinia virus recombinants expressing the hepatitis B virus surface antigen and the herpes simplex virus ...
... an adjuvanted killed virus noninfectious vaccine, an adjuvanted subunite vaccine and a nonadjuvanted canarypox virus-vectored ... Feline leukemia virus (FeLV) is an RNA virus in the subfamily Oncovirinae belonging to the Retroviridae family. The virus ... Merial produces a recombinant vaccine consisting of canarypox virus carrying FeLV gag and env genes (sold as PUREVAX FeLV in ... Once the virus has entered the cat, there are six stages to a FeLV infection[citation needed]: Stage One: The virus enters the ...
Juncopox virus, Mynahpox virus, Psittacinepox virus, Sparrowpox virus, Starlingpox virus, Pigeonpox virus, Turkeypox virus and ... Canarypox virus (CNPV) is a member of the Poxviridae family. Canarypox viruses, as with other bird pox viruses, are in the ... Canarypox virus (CNPV) is an Avipoxvirus and etiologic agent of canarypox, a disease of wild and captive birds that can cause ... leukaemia virus, HIV and cancers; such as melanoma and colorectal cancers. A strain of canarypox virus modified to carry feline ...
Juncopox virus, Mynahpox virus, Psittacinepox virus, Sparrowpox virus, Starlingpox virus, Pigeonpox virus, Canarypox virus and ... but most of our knowledge comes from the study of fowlpox virus and canarypox virus as they are the only species with full ... Turkeypox virus is a virus of the family Poxviridae and the genus Avipoxvirus that causes turkeypox. It is one of the most ... Turkeypox virus, like other Avipoxviruses, is an enveloped, double-stranded DNA virus with a large, linear genome of ...
... a disease of camels Canarypox, a disease of wild and captive birds Cowpox, a rodent disease that can infect cattle, and also ... a highly contagious illness caused by a primary infection with varicella zoster virus (VZV) Buffalopox, a disease of buffaloes ... caused by either of two virus variants, Variola major and Variola minor Hemorrhagic smallpox, Blackpox a severe manifestation ... Quokkapox a disease caused by the Quokkapox virus, also called marsupialpox. Rabbitpox, an iatrogenic infectious disease of ...
African horse sickness virus, rabbit hemorrhagic disease virus, herpes simplex virus, hepatitis C virus, bluetongue virus, ... A prime-dose regimen with canarypox ALVAC-HIV (vCP1521) vaccine and HIV-1 gp120 AIDSVAX B/E was found to be safe, well ... canine distemper virus, feline leukemia virus, feline immunodeficiency virus, equine influenza virus, equine herpes virus, ... Vaccines against several pathogens including avian influenza virus, Newcastle disease virus, cytomegalovirus, ...
Canarypox virus Flamingopox virus Fowlpox virus Juncopox virus Mynahpox virus Penguinpox virus Pigeonpox virus Psittacinepox ... virus Quailpox virus Sparrowpox virus Starlingpox virus Turkeypox virus Viruses in Avipoxvirus are enveloped. Genomes are ... Vaccines have been developed from some species of the virus, such as Fowlpox, Canarypox, Pigeonpox, and Quailpox to help ... When the mosquito moves to a susceptible host and feeds, the new host is infected with the virus. The virus can also be ...
February 2007). "Evaluation of the ability of canarypox-vectored equine influenza virus vaccines to induce humoral immune ... pdm09-like virus an A/Hong Kong/2671/2019 (H3N2)-like virus a B/Washington/02/2019 (B/Victoria lineage)-like virus a B/Phuket/ ... pdm09-like virus an A/Hong Kong/45/2019 (H3N2)-like virus a B/Washington/02/2019 (B/Victoria lineage)-like virus a B/Phuket/ ... pdm09-like virus; an A/HongKong/45/2019 (H3N2)-like virus; a B/Washington/02/2019-like virus (B/Victoria lineage); a B/Phuket/ ...
Empty group QI01KA01 Pacheco's virus/herpesvirus Empty group Empty group QI01KD01 Canary pox virus QI01KD02 Pacheco's virus/ ... disease virus + newcastle disease virus/paramyxovirus QI01AD12 Avian pox virus QI01AD13 Avian leucosis virus QI01AD14 Avian ... disease virus + newcastle disease virus/paramyxovirus + avian rhinotracheitis virus QI01AA07 Avian infectious bronchitis virus ... avian herpes virus (Marek's disease) QI01AD16 Avian herpes virus (Marek's disease) + avian infectious bursal disease virus ( ...
This allows the virus to theoretically carry 22 to 40 genes. Although this is significantly larger than other viruses in its ... such as Cytomegalovirus and Canarypox. By comparison, a Science article reported that China had approved CanSino's Ebola ... Once the virus has successfully gained entry into the host cell, the endosome acidifies, which alters virus topology by causing ... "Virus Taxonomy: 2020 Release". International Committee on Taxonomy of Viruses (ICTV). March 2021. Retrieved 22 May 2021. ...
Because of the virus's ability to rapidly respond to selective pressures imposed by the immune system, the population of virus ... The canarypox vector is the first candidate HIV vaccine that has induced cross-clade functional CTL responses. The first phase ... Because this amino acid is foreign to the human body, the virus cannot reproduce. Viruses portal Cabotegravir COVID-19 vaccine ... Some vaccines based on the virus envelope have protected chimpanzees or macaques from homologous virus challenge, but in ...
... since the first cases of what is now recognized as human immunodeficiency virus (HIV) infection were identified in 1981, the ... If the patient is not taking a medication, the virus does not develop resistance to it, and the medication is still useful for ... 16,402 healthy participants aged 18-30 years received either 4 priming injections of recombinant canarypox vector vaccine ( ... Address abnormalities in psychological and neurologic development, due, in part, to the tropism of the virus for CNS tissue in ...
... since the first cases of what is now recognized as human immunodeficiency virus (HIV) infection were identified in 1981, the ... If the patient is not taking a medication, the virus does not develop resistance to it, and the medication is still useful for ... 16,402 healthy participants aged 18-30 years received either 4 priming injections of recombinant canarypox vector vaccine ( ... Address abnormalities in psychological and neurologic development, due, in part, to the tropism of the virus for CNS tissue in ...
... since the first cases of what is now recognized as human immunodeficiency virus (HIV) infection were identified in 1981, the ... If the patient is not taking a medication, the virus does not develop resistance to it, and the medication is still useful for ... 16,402 healthy participants aged 18-30 years received either 4 priming injections of recombinant canarypox vector vaccine ( ... Address abnormalities in psychological and neurologic development, due, in part, to the tropism of the virus for CNS tissue in ...
... developed from a canarypox virus carrying the prM/E genes of West Nile virus that will protect horses against a West Nile virus ... such as West Nile virus in North America and Nipah virus in Malaysia and Singapore in 1999, resulted in serious illnesses and ... regulation of apoptosis by viruses infecting insects, and Semliki Forest virus infection of laboratory mice as models to study ... The first presentation gives an overview of the emergence of zoonotic viruses maintained by wildlife reservoir hosts and ...
... is a blood-borne virus typically transmitted via sexual intercourse, shared intravenous drug paraphernalia, and mother-to-child ... 16,402 healthy participants aged 18-30 years received either 4 priming injections of recombinant canarypox vector vaccine ( ... Low plasma human immunodeficiency virus type 2 viral load is independent of proviral load: low virus production in vivo. J ... Lower human immunodeficiency virus (HIV) type 2 viral load reflects the difference in pathogenicity of HIV-1 and HIV-2. J ...
BPSV, bovine papular stomatitis virus BV-AR02 (NC_005337); CMLV, camelpox virus CMS (AY009089); CNPV, canarypox virus Wheatley ... monkeypox virus Zaire-96-I-16 (AF380138); MYXV, myxoma virus Lausanne (NC_001132); ORFV, Orf virus OV-SA00 (NC_005336); PCPV, ... fowlpox virus NVSL (NC_002188); GTPV, goatpox virus Pellor (NC_004003); LSDV, lumpy skin disease virus NI-2490 (NC_003027); ... pigeonpox virus FeP2 (NC_024447); RCNV, raccoonpox virus Herman (NC_027213); RDPV, red deer pox virus (KM502564); RFV, rabbit ...
... camelpox virus, AY009089.1; canarypox virus, NC005309.1; Cotia virus, KM595078.1; cowpox virus, DQ437593.1; deerpox virus, ... vaccinia virus, M35027.1; variola major virus, L22579.1; Yaba monkey tumor virus, NC005179.1; Yaba-like disease virus, ... goatpox virus, MH381810.1; lumpy skin disease virus, NC003027.1; monkeypox virus, DQ011157.1; myxoma virus, NC001132.2; rabbit ... fibroma virus, NC001266.1; sheeppox virus, NC004002.1; swinepox virus, NC003389.1; taterapox virus, NC008291.1; ...
Juncopox virus, Mynahpox virus, Psittacinepox virus, Sparrowpox virus, Starlingpox virus, Pigeonpox virus, Turkeypox virus and ... Canarypox virus (CNPV) is a member of the Poxviridae family. Canarypox viruses, as with other bird pox viruses, are in the ... Canarypox virus (CNPV) is an Avipoxvirus and etiologic agent of canarypox, a disease of wild and captive birds that can cause ... leukaemia virus, HIV and cancers; such as melanoma and colorectal cancers. A strain of canarypox virus modified to carry feline ...
... signal transducer and activator of transcription 3 activation in CD16+ monocytes was associated with an increased risk of virus ... We tested the ability of the Aventis Pasteur live recombinant canarypox vector (ALVAC)-SIV, DNA-SIV and Ad26-SIV vaccine prime ... The canarypox virus vector ALVAC induces distinct cytokine responses compared to the vaccinia virus-based vectors MVA and NYVAC ... including Zika virus, Ebola virus, Dengue virus, Epstein-Barr virus and SIV/HIV26,27. We next investigated monocyte-mediated ...
... camelpox virus, AY009089.1; canarypox virus, NC005309.1; Cotia virus, KM595078.1; cowpox virus, DQ437593.1; deerpox virus, ... vaccinia virus, M35027.1; variola major virus, L22579.1; Yaba monkey tumor virus, NC005179.1; Yaba-like disease virus, ... goatpox virus, MH381810.1; lumpy skin disease virus, NC003027.1; monkeypox virus, DQ011157.1; myxoma virus, NC001132.2; rabbit ... fibroma virus, NC001266.1; sheeppox virus, NC004002.1; swinepox virus, NC003389.1; taterapox virus, NC008291.1; ...
Feline interleukin-2 recombinant canarypox virus * Cats POM-V Great Britain Oncept IL-2 Boehringer Ingelheim Vetmedica Gmbh EU/ ...
Immunotherapy using biologic response modifiers from vaccinia used after surgery or canarypox virus vector (used intratumorally ... Feline leukemia virus and FSV are not involved in the pathogenesis of ISS. ... In cats, feline leukemia virus infection has been infrequently associated with their development; whether this is a coincidence ... An association with adjuvanted, inactivated rabies and feline leukemia virus vaccinations and long-acting corticosteroid ...
ALVAC-CEA vaccine A cancer vaccine containing a canary pox virus (ALVAC) combined with the human carcinoembryonic antigen (CEA ...
... and adult WNV-naïve horses before and after vaccination with a live canarypox virus-vectored vaccine (7) or a killed virus ... responses induced by the killed-virus vaccines were higher and lasted longer than did those induced by the live canarypox virus ... West Nile virus-specific IgG1 was detected in the sera of most horses 14 days after vaccination. Serum anti-WNV IgG1 and ... OBJECTIVE To compare antibody responses of horses naturally infected with West Nile virus (WNV) and those vaccinated against ...
Transient plant-based expression systems are a rapid and highly scalable means of producing such African horse sickness virus ( ... alternate safe and effective vaccination strategies such as virus-like particles (VLPs) are being investigated. ... well as capable of eliciting a weak neutralizing humoral immune response in these target animals against homologous AHSV virus. ... An African horse sickness virus serotype 4 recombinant canarypox virus vaccine elicits specific cell-mediated immune responses ...
Canarypox virus Current Synonym true false 85808014 Canary pox virus Current Synonym true false ...
Avian Pox Viruses (e.g. pigeon pox, magpie pox, canary pox); *Bacterial infections and abscesses ... Amazon tracheitis virus (a herpesvirus of Amazon parrots that is often associated with respiratory disease signs) ...
... gene-size fragments of DNA from one organism and transfer them to another by way of a vector virus (such as the canarypox ... Examples include feline leukemia virus (FeLV) and canine Lyme borreliosis (Borrelia burgdorferi) vaccine. It is important to ... Note: Vaccines that do NOT contain adjuvant include: modified-live virus vaccines, avirulent-live bacterial vaccines [e.g., ... and feline immunodeficiency virus were not available at the time these recommendations were made)a. As recently as 1996, a ...
haemagglutinin gene from equine influenza virus A2/Kentucky/94 or equine influenza virus A2/Newmarket/2/93 ... for the study of the safety of a sucutaneous administration of a recombinant canarypoxvirus expressing FELV genes. Merial cats ... env and gag genes of the type A virus of feline leukemia (FELV) ... env and gag genes of the type A virus of feline leukemia (FELV ... for the study of the safety of a subcutaneous administration of a recombinant canarypoxvirus expressing FELV genes. Merial cats ...
Canine distemper virus (CDV) is a significant threat to domestic and wildlife carnivore species worldwide. Vaccinations against ... we evaluated the safety and immunogenicity of a commercial canine multivalent vaccine that included canarypoxvirus recombinant ...
Camelpox virus. n. NCBI Refseq. 215. 44088. Canarypox virus. n. NCBI Refseq. 215. ... Bovine papular stomatitis virus. n. NCBI Refseq. 215. 693272. Cafeteria roenbergensis virus BV-PW1 (CroV). n. NCBI Refseq. 215 ... Ostreococcus lucimarinus virus 2 (OlV2). n. NCBI Refseq. 215. 754064. Ostreococcus lucimarinus virus OlV5. n. NCBI Refseq. 215 ... Viruses comprise an extensive pool of mobile genetic elements in eukaryote cell cultures and human clinical samples. ...
... rekombinovaný s Canarypox virem (vCP2242), Virus influenzy A/equi/Richmond/1/07 (H3N8) rekombinantní canarypox virus (vCP3011) ...
Canarypox virus. Canary Pox. 1. 1. 0. 0 0. 87. Canine adenovirus type 1. Fox Encephalitis, Infectious Canine Hepatitis. 3. 3. 0 ... Infectious pancreatic necrosis virus. 1. 0. 2. 0 2. 136. Infectious salmon anemia virus. Infectious Salmon Anemia. 1. 1. 1. 0 3 ... Influenza virus. Influenza (flu). 205. 107. 53. 449 152. 138. Japanese encephalitis virus. Japanese encephalitis. 14. 3. 12. 1 ... Reticuloendotheliosis Virus. Tumors, wasting syndrome. 1. 0. 3. 0 0. 164. Rift Valley Fever virus. Rift valley fever. 3. 0. 4. ...
Many strains of virus are recognized and naturally infect the species given in their name. ... Canary poxvirus. TRANSMISSION: *Direct: by water and feed.. *Indirect: by vectors such as mosquitoes and others insects. ... Gerlach, H. (1994) Avian Medicine: Principles and Applications, Section 5, Chapter 32: Viruses. 865-874. ...
env and gag genes of the type A virus of feline leukemia (FELV) ... of a sucutaneous administration of a recombinant canarypoxvirus ... env and gag genes of the type A virus of feline leukemia (FELV) ... a subcutaneous administration of a recombinant canarypoxvirus ...
... protection in large human trials consisted of a recombinant canary pox virus vector vaccine (ALVAC-HIV (vCP1521)) and a ... Ebola virus vaccines are overseen by the R&D blueprint, but are included in this PDVAC overview to reflect the pipeline status ... Live recombinant vaccinia virus protects chimpanzees against hepatitis B. Nature 1984;311:67-9.doi:10.1038/311067a0. ... Zika virus. N Engl J Med 2016;374:1552-63.doi:10.1056/NEJMra1602113. ...
A recombinant canarypox vector vaccine expressing distemper virus proteins is licensed for use in ferrets; the American ... Canine distemper virus, or CDV, is a paramyxovirus closely related to the viruses of measles and rinderpest. The fragile, ... Alternatively, measles virus vaccine induces immunity to canine distemper virus in the presence of relatively greater levels of ... Disease follows virus replication in these tissues. The degree of viremia and extent of viral spread to various tissues is ...
Canary Pox Vaccination With Live Embryo-Attenuated Virus. Categories: Publication; Types: Citation; Tags: Serinus canarius, V ... Reassortant virus derived from avian and human influenza A viruses is attenuated and immunogenic in monkeys. ... avian influenza virus, hybrids, All tags... influenza A virus, recombination, use, vaccines, Fewer tags ... Avian-human reassortant influenza A viruses derived by mating avian and human influenza A viruses. ...
... a recombinant live canarypox vaccine that express prM and E genes formulated with Carbopol adjuvant (Recombitek®, MerialLtd., ... VIRUS. West Nile virus (WNV) is a small enveloped virus about 50 nm in diameter. The genomic RNA is enclosed within a ... Serological evidence of West Nile virus, Usutu virus and Sindbis virus infection of birds in the UK. J Gen Virol. 2003;84:2807- ... GeneBank Accesions: Usutu virus (USUV) (AY453412), Japanese encephalitis virus (JEV) (NC_001437), St. Louis encephalitis virus ...
The ALVAC vCP1521 vector is a modified version of a bird virus called canarypox. While the natural form of the virus can be ... 4 Uganda Virus Research Institute-Medical Research Council, Entebbe, Uganda,5 Uganda Virus Research Institute-International ... The virus was originally designated as belonging to subtype E, but it has since been recognized that this subtype is largely a ... The other gp120 is from a CRF01_AE virus isolate name A244 or CM244 that was obtained in Northern Thailand (CM=Chang Mai) in ...
based on negrier s, escudier b, lasset c, et al: Canary-pox virus- controls on cell growth. This treatment should be given with ...
Canarypox Virus. *cephaloorbital index. References in periodicals archive ? Marc Auge argues that contemporary non-lieux ( ...
the recombinant canarypox virus vCP2017 strain, that expresses the WNV prM/prE genes (Recombitek equine WNV vaccine, Merial) • ... West Nile virus (WNV) is a mosquito-borne virus belonging to the genus Flavivirus in the Flaviviridae family. The viral genome ... Serologically, West Nile virus is a member of the Japanese encephalitis serocomplex, which includes antigenic related viruses ... Not all infected hosts transmit the virus, but only those in which the virus replicates efficiently enough to reach viremias ...
His research integrates issues of HIV vaccine, Canarypox, Transcriptome and Zika virus in his study of Vaccination. ... The Virus study combines topics in areas such as Polymerase chain reaction and Genotype. His Vaccination research is ... Vaccine protection against Zika virus from Brazil. Rafael A. Larocca;Peter Abbink;Jean Pierre S. Peron;Paolo M. de A. Zanotto. ... His research integrates issues of RNA, Peripheral blood mononuclear cell and Genotype in his study of Virus. His Viral load ...
The four "prime" jabs contained a canarypox virus that is incapable of replicating in cells and carries the genetic ... Whats more, the virus deploys multiple tactics to hide from the immune system. One tactic the virus uses is to cover parts of ... Three years later, scientists pinned the blame for AIDS on a virus dubbed HIV, or human immunodeficiency virus. Margaret ... "If [the immune system] doesnt get rid of the virus within 24 hours, the virus has won." ...
  • Avipoxvirus (canarypox, fowlpox. (cdc.gov)
  • We tested the ability of the Aventis Pasteur live recombinant canarypox vector (ALVAC)-SIV, DNA-SIV and Ad26-SIV vaccine prime modalities together with two ALVAC-SIV + gp120 protein boosts to reduce the risk of SIV mac251 acquisition in rhesus macaques. (nature.com)
  • In the RV144 trial, volunteers were vaccinated twice with the HIV recombinant Aventis Pasteur's canarypox vector (ALVAC) and then two additional times with ALVAC-HIV in combination with two gp120 envelope (Env) proteins formulated in alum. (nature.com)
  • The ALVAC vCP1521 vector is a modified version of a bird virus called canarypox. (typepad.com)
  • CDV vaccines contain modified-live virus (MLV), high-titer, low-passage (less attenuated) modified-live virus, or a (recombinant) canarypox vector with targeted CDV genes. (aaha.org)
  • The HIV-1 prime boost phase I/II vaccine trial using a recombinant canarypox vector, vCP1521, containing subtype E env (gp120), and subtype B env (gp41), gag and protease has started in Thailand. (who.int)
  • The most successful HIV-1 clinical trial to date used a non-replicating canarypox viral vector and protein boosting, yet its modest efficacy left room for improvement. (asu.edu)
  • One such vaccinia virus vector, NYVAC-KC, was specifically designed to replicate in humans and had several immune modulators deleted to improve immunogenicity and reduce pathogenicity. (asu.edu)
  • ALVAC vCP1521 contains the gene encoding the gp120 protein from a virus codenamed 92TH023 that was isolated from a Thai individual in Bangkok by the WHO Network for HIV Isolation and Characterization . (typepad.com)
  • Serum anti-WNV IgG1 and neutralizing antibody responses induced by the killed-virus vaccines were higher and lasted longer than did those induced by the live canarypox virus-vectored vaccine. (avma.org)
  • Virus-like particles (VLPs) are considered a safe and effective alternative to live attenuated vaccines for many viral diseases [ 25 ]. (biomedcentral.com)
  • vaccines for canine Lyme borreliosis, canine coronavirus, canine giardiasis, feline infectious peritonitis, feline Bordetella bronchiseptica, feline giardiasis, and feline immunodeficiency virus were not available at the time these recommendations were made ) a . (vin.com)
  • Although it may seem notable that two of the gp120 proteins in the vaccines come from viruses isolated from the population involved in the RV144 trial, the antibody responses induced by the vaccine combination have been shown to have no neutralizing activity against primary isolates from subtype CRF01_AE (including the 92TH023 virus from which one of the gp120s is derived). (typepad.com)
  • The main problem these variants pose for vaccines is that some mutations are in parts of the virus that the immune system tends to attack. (chemwatch.net)
  • Although this outbreak was eventually controlled using inactivated virus vaccines, the epidemic caused significant economic losses not only from the disease in livestock but also from trade restrictions. (biomedcentral.com)
  • Vaccines Introduction Types Active And Passive Immunization And Whole Virus Vaccines Will Be A Thing Of The Past And Here's Why. (niazitv.pk)
  • Antiviral drugs are not available for the treatment of parvovirus B19V infection, and no vaccines for the virus are currently approved. (justia.com)
  • Inactivated vaccines contain a killed version of FeLV, so the virus cannot replicate in the host. (catsworldclub.com)
  • Poxvirus host range genes and virus-host spectrum: a critical review. (cdc.gov)
  • Experiment outside containment (clinical trial) for the study of the safety of a sucutaneous administration of a recombinant canarypoxvirus expressing FELV genes. (biosafety.be)
  • Nucleotide sequence of the avian influenza A/Mallard/NY/6750/78 virus polymerase genes. (usgs.gov)
  • " A canarypox vaccine expressing multiple human immunodeficiency virus type 1 genes given alone or with Rgp120 elicits broad and durable CD8+ cytotoxic T lymphocyte responses in seronegative volunteers " , J Infec Dis , vol. 180, pp. 290-8, 1999. (emmes.com)
  • PUREVAX Recombinant FeLV - canarypox-vectored recombinant vaccine is recommended for the vaccination of healthy cats 8 weeks of age and older as an aid in the prevention of disease due to feline leukemia virus. (senacmoda.info)
  • Canarypox virus (CNPV) is an Avipoxvirus and etiologic agent of canarypox, a disease of wild and captive birds that can cause significant losses. (wikipedia.org)
  • Canarypox viruses, as with other bird pox viruses, are in the genera of Avipoxvirus. (wikipedia.org)
  • OBJECTIVE To compare antibody responses of horses naturally infected with West Nile virus (WNV) and those vaccinated against WNV, to identify whether vaccination interferes with the ability to diagnose WNV infection, and to determine the duration of antibody responses after vaccination. (avma.org)
  • SAMPLE Sera from horses naturally infected with WNV (n = 10) and adult WNV-naïve horses before and after vaccination with a live canarypox virus-vectored vaccine (7) or a killed virus vaccine (8). (avma.org)
  • West Nile virus-specific IgG1 was detected in the sera of most horses 14 days after vaccination. (avma.org)
  • Due to safety concerns with the current live, attenuated AHS vaccine, alternate safe and effective vaccination strategies such as virus-like particles (VLPs) are being investigated. (biomedcentral.com)
  • Canary Pox Vaccination With Live Embryo-Attenuated Virus. (usgs.gov)
  • Nelson L. Michael spends much of his time researching Virology, Immunology, Antibody, Virus and Vaccination. (research.com)
  • His research integrates issues of HIV vaccine, Canarypox, Transcriptome and Zika virus in his study of Vaccination. (research.com)
  • Outbreak of severe zoonotic vaccinia virus infection, Southeastern Brazil. (cdc.gov)
  • and the retrograde axonal transport of the virus to the central nervous system via infection of olfactory or peripheral neurons ( Cho and Diamond, 2012 ). (izs.it)
  • West Nile virus (WNV) infection is a mosquito-borne zoonosis. (izs.it)
  • A high titer of virus was detected in plasma on day 2 after infection, and viremia persisted for 5 days. (eurekamag.com)
  • A high prevalence of infections, such as candidiasis and varicella-zoster virus infection, must also be anticipated, and appropriate prevention and treatment strategies must be initiated. (medscape.com)
  • After human immunodeficiency virus infection, JE may be the leading cause of viral encephalitis worldwide. (cdc.gov)
  • West Nile virus (WNV), a flavivirus of the Flaviviridae family, is maintained in nature in an enzootic transmission cycle between avian hosts and ornithophilic mosquito vectors, although the virus occasionally infects other vertebrates. (wjgnet.com)
  • West Nile virus (WNV) is a mosquito-borne virus belonging to the genus Flavivirus in the Flaviviridae family. (izs.it)
  • West Nile virus (WNV) is a mosquito-borne flavivirus that emerged in North America and caused numerous cases of human encephalitis, thus urging the development of a vaccine. (eurekamag.com)
  • The other gp120 is from a CRF01_AE virus isolate name A244 or CM244 that was obtained in Northern Thailand (CM=Chang Mai) in 1990 by Francine McCutchan and colleagues . (typepad.com)
  • Therefore, subclass V1V2 and gp120 levels were assessed against the canarypox-expressed gp120 (92TH023) and AIDSVAX B/E gp120 (MN and AE244) antigens. (zuluecco.com)
  • The vaccinia virus is commonly used as a prototype and can be consulted for further information. (wikipedia.org)
  • IMSEAR at SEARO: Cytotoxic T lymphocyte responses to vaccinia virus antigens but not HIV-1 subtype E envelope protein seen in HIV-1 seronegative Thais. (who.int)
  • Kantakamalakul W, Cox J, Kositanont U, Siritantikorn S, Limbach K, Birx D, Thongcharoen P, Puthavathana P. Cytotoxic T lymphocyte responses to vaccinia virus antigens but not HIV-1 subtype E envelope protein seen in HIV-1 seronegative Thais. (who.int)
  • We have demonstrated that although 4 from 15 human immunodeficiency virus type 1 (HIV-1) seronegative Individuals showed cytotoxic T lymphocyte (CTL) responses to vaccinia virus antigens, none of them showed specific CTL responses to subtype E Env after in vitro stimulation. (who.int)
  • Recombinant HIV-vaccinia viruses were used to express HIV antigens in B-cell lines established from subjects seropositive for HIV and seronegative controls. (springernature.com)
  • ALVAC-CEA vaccine A cancer vaccine containing a canary pox virus (ALVAC) combined with the human carcinoembryonic antigen (CEA) gene. (keywen.com)
  • The 92TH023 virus isolate uses the CCR5 co-receptor to enter cells, like almost all primary HIV isolates. (typepad.com)
  • Biological characterization and next-generation genome sequencing of the unclassified Cotia virus SPAn232 ( Poxviridae ). (cdc.gov)
  • Avian-human reassortant influenza A viruses derived by mating avian and human influenza A viruses. (usgs.gov)
  • Reassortant virus derived from avian and human influenza A viruses is attenuated and immunogenic in monkeys. (usgs.gov)
  • In influenza vaccine manufacturing, the virus is propagated in the embryonic chick and sloughed into the allantoic fluid that is harvested to produce the vaccine. (vaclib.org)
  • The virus was originally designated as belonging to subtype E, but it has since been recognized that this subtype is largely a circulating recombinant form now known by the name CRF01_AE. (typepad.com)
  • Like Bluetongue virus (BTV), the prototype Orbivirus [ 6 ], the subcore of AHSV is composed of 120 copies of structural protein VP3 and is covered by a layer of VP7 trimers forming the core particle. (biomedcentral.com)
  • Here we use a neutralizing epitope determinant on the dengue envelope (E) protein as an immunogen to be vectored by a measles virus (MV) vaccine. (asu.edu)
  • Generally CNPV is considered a disease of songbirds, such as canaries, magpies and nightingales, and is associated with higher mortality rates when compared to other avian pox viruses. (wikipedia.org)
  • Avian pox viruses also cause significant economic losses in domestic poultry and remain a problem in the conservation of endemic bird species inhabiting islands. (wikipedia.org)
  • The general symptoms of CNPV are similar to those of other species of avian pox viruses and are characterised by pustules and diphtheria or pneumonia-like symptoms. (wikipedia.org)
  • It has thus far been reported that around 232 bird species (from 23 disparate orders) are affected by avian pox virus. (wikipedia.org)
  • Canine distemper virus , or CDV, is a paramyxovirus closely related to the viruses of measles and rinderpest. (msdvetmanual.com)
  • Two types of recombinant measles virus were produced: pB(+)MVvac2(DIII-S,S)P and pB(+)MVvac2(DIII-S)N. Virus recovered from pB(+)MVvac2(DIII-S,S)P was viable. (asu.edu)
  • Bluetongue virus (BTV) is an arthropod-borne pathogen that causes an often fatal, hemorrhagic disease in ruminants. (biomedcentral.com)
  • The sticking together of insoluble antigens such as bacteria, viruses or erythrocytes by a particular antibody. (vaclib.org)
  • Canarypox virus (CNPV) is a member of the Poxviridae family. (wikipedia.org)
  • One is from the subtype B HIV-1 isolate MN, a CXCR4-using virus originally isolated from a child with AIDS-related complex (as it was then known) by George Shaw and colleagues in 1984. (typepad.com)
  • New serotype 2 and attenuated serotype 1 Marek's disease vaccine viruses: Comparative efficacy. (usgs.gov)
  • Genetic analysis of trial viruses revealed increased vaccine efficacy against viruses matching the vaccine strain at V2 residue 169. (elsevier.com)
  • Few semi-permissive cell lines have been described and those few that exist fail to express virus in amounts suitable for vaccine production. (justia.com)
  • JE viruses isolated from human cases in Japan in 1935 and in Beijing in 1949 provided the prototype Nakayama, Beijing and P3 strains respectively that are in principal use in vaccine production. (cdc.gov)
  • Yaba-like disease virus, NC002642.1. (cdc.gov)
  • As the disease progresses blisters get progressively larger and form nodules where the virus can multiply. (wikipedia.org)
  • Studies on Tissue Culture Adapted Fowl Pox Disease Vaccine With Particular Reference to Immunogenicity of Intracellular and Extracellular Virus. (usgs.gov)
  • Disease follows virus replication in these tissues. (msdvetmanual.com)
  • Since its introduction in the Americas, the virus spread across the continent with worrisome consequences in bird mortality and a considerable number of outbreaks among humans and horses, which have resulted in the largest epidemics of neuroinvasive WNV disease ever documented. (wjgnet.com)
  • the mechanism of virus persistence in animal hosts in Europe leading to endemization of the disease is still unknown. (izs.it)
  • The shot uses a common cold virus that has been altered so that it no longer causes disease. (chemwatch.net)
  • Although relatively unstable in the environment, the wide host range and worldwide disease distribution allow for increased risk of virus exposure for free-roaming dogs. (aaha.org)
  • The treatment of human immunodeficiency virus (HIV) disease depends on the stage of the disease and any concomitant opportunistic infections. (medscape.com)
  • In this study, we generated recombinant RNA replicon particles based on single-cycle vesicular stomatitis virus (VSV) vectors. (biomedcentral.com)
  • These vectors were combined with HIV-1 Gag/dgp41 virus-like particles (VLPs) produced in the tobacco-relative Nicotiana benthamiana. (asu.edu)
  • Three years later, scientists pinned the blame for AIDS on a virus dubbed HIV, or human immunodeficiency virus. (chemwatch.net)
  • Here we report the existence of human immunodeficiency virus (HlV)-specific CTL in persons infected with this virus, the aetiological agent of AIDS (acquired immunodeficiency syndrome). (springernature.com)
  • ART is the mainstay in human immunodeficiency virus (HIV) treatment. (medscape.com)
  • Canine distemper virus (CDV) is a significant threat to domestic and wildlife carnivore species worldwide. (vin.com)
  • Because CDV is a major cause of mortality in gray foxes ( Urocyon cinereoargenteus ), we evaluated the safety and immunogenicity of a commercial canine multivalent vaccine that included canarypoxvirus recombinant CDV and modified live (MLV) canine parvovirus type-2 (CPV2) components for use in gray foxes. (vin.com)
  • 3] In that document, 3-year booster intervals in adult dogs are recommended for distemper, parvovirus, adenovirus-2 and parainfluenza virus. (vin.com)
  • Genome of Alaskapox virus , a novel orthopoxvirus isolated from Alaska. (cdc.gov)
  • These transmit the virus from infected birds to non-infected birds. (wikipedia.org)
  • Not all infected hosts transmit the virus, but only those in which the virus replicates efficiently enough to reach viremias sufficiently high to infect mosquitoes through blood feeding. (izs.it)
  • Moreover, both neutralizing antibodies against tier 1 viruses and increased CD4+ functionality were observed (13). (zuluecco.com)
  • Virus-specific cytotoxic T lymphocytes (CTL) which kill virus-infected cells are thought to be a major host defence against viral infections1-11. (springernature.com)
  • The mosquito-borne mode of JE transmission was elucidated with the isolation of JE virus from Culex tritaeniorhynchus mosquitoes in 1938 and in field studies that established the role of aquatic birds and pigs in the viral enzootic cycle. (cdc.gov)
  • The virus is transmitted among birds via the bite of infected mosquitoes and incidentally humans and other mammals may become infected. (izs.it)
  • Dengue virus infects millions of people every year. (asu.edu)
  • The virus initially replicates in the lymphatic tissue of the respiratory tract. (msdvetmanual.com)
  • Plant produced chimeric AHSV-6 VLPs were found to be safe for administration into 6 month old foals as well as capable of eliciting a weak neutralizing humoral immune response in these target animals against homologous AHSV virus. (biomedcentral.com)
  • It's also a tricky virus to pin down, with many variants and an uncanny ability to evade the immune system. (chemwatch.net)
  • Your cat could also be one of the lucky ones that fight off the virus with their immune system, meaning they could have many years ahead of them before any complications arise. (catsworldclub.com)
  • Transient plant-based expression systems are a rapid and highly scalable means of producing such African horse sickness virus (AHSV) VLPs for vaccine purposes. (biomedcentral.com)
  • Humans and horses are considered accidental and dead end of the virus and do not contribute to the transmission cycle as they develop a low and transitory viremia not considered able to infect competent mosquito species. (izs.it)