Camptotheca: A plant genus of the family NYSSACEAE (sometimes classified in the CORNACEAE family). It is a source of CAMPTOTHECIN.Plants, Medicinal: Plants whose roots, leaves, seeds, bark, or other constituent parts possess therapeutic, tonic, purgative, curative or other pharmacologic attributes, when administered to man or animals.Camptothecin: An alkaloid isolated from the stem wood of the Chinese tree, Camptotheca acuminata. This compound selectively inhibits the nuclear enzyme DNA TOPOISOMERASES, TYPE I. Several semisynthetic analogs of camptothecin have demonstrated antitumor activity.Aristolochic Acids: Nitro-phenanthrenes occurring in ARISTOLOCHIACEAE and other plants. They derive from stephanine (APORPHINES) by oxidative ring cleavage. The nitro group is a reactive alkylator (ALKYLATING AGENTS) that binds to biological macromolecules. Ingestion by humans is associated with nephropathy (NEPHRITIS). There is no relationship to the similar named aristolochene (SESQUITERPENES).Webcasts as Topic: Transmission of live or pre-recorded audio or video content via connection or download from the INTERNET.Replication Protein A: A single-stranded DNA-binding protein that is found in EUKARYOTIC CELLS. It is required for DNA REPLICATION; DNA REPAIR; and GENETIC RECOMBINATION.H-Y Antigen: A sex-specific cell surface antigen produced by the sex-determining gene of the Y chromosome in mammals. It causes syngeneic grafts from males to females to be rejected and interacts with somatic elements of the embryologic undifferentiated gonad to produce testicular organogenesis.DNA Damage: Injuries to DNA that introduce deviations from its normal, intact structure and which may, if left unrepaired, result in a MUTATION or a block of DNA REPLICATION. These deviations may be caused by physical or chemical agents and occur by natural or unnatural, introduced circumstances. They include the introduction of illegitimate bases during replication or by deamination or other modification of bases; the loss of a base from the DNA backbone leaving an abasic site; single-strand breaks; double strand breaks; and intrastrand (PYRIMIDINE DIMERS) or interstrand crosslinking. Damage can often be repaired (DNA REPAIR). If the damage is extensive, it can induce APOPTOSIS.DNA Replication: The process by which a DNA molecule is duplicated.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Telomere: A terminal section of a chromosome which has a specialized structure and which is involved in chromosomal replication and stability. Its length is believed to be a few hundred base pairs.Prodrugs: A compound that, on administration, must undergo chemical conversion by metabolic processes before becoming the pharmacologically active drug for which it is a prodrug.Epoxy Compounds: Organic compounds that include a cyclic ether with three ring atoms in their structure. They are commonly used as precursors for POLYMERS such as EPOXY RESINS.Liposomes: Artificial, single or multilaminar vesicles (made from lecithins or other lipids) that are used for the delivery of a variety of biological molecules or molecular complexes to cells, for example, drug delivery and gene transfer. They are also used to study membranes and membrane proteins.Drug Delivery Systems: Systems for the delivery of drugs to target sites of pharmacological actions. Technologies employed include those concerning drug preparation, route of administration, site targeting, metabolism, and toxicity.Patents as Topic: Exclusive legal rights or privileges applied to inventions, plants, etc.Drug Carriers: Forms to which substances are incorporated to improve the delivery and the effectiveness of drugs. Drug carriers are used in drug-delivery systems such as the controlled-release technology to prolong in vivo drug actions, decrease drug metabolism, and reduce drug toxicity. Carriers are also used in designs to increase the effectiveness of drug delivery to the target sites of pharmacological actions. Liposomes, albumin microspheres, soluble synthetic polymers, DNA complexes, protein-drug conjugates, and carrier erythrocytes among others have been employed as biodegradable drug carriers.Affinity Labels: Analogs of those substrates or compounds which bind naturally at the active sites of proteins, enzymes, antibodies, steroids, or physiological receptors. These analogs form a stable covalent bond at the binding site, thereby acting as inhibitors of the proteins or steroids.Sulfonic Acids: Inorganic or organic oxy acids of sulfur which contain the RSO2(OH) radical.Water: A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Quinolinium CompoundsSalts: Substances produced from the reaction between acids and bases; compounds consisting of a metal (positive) and nonmetal (negative) radical. (Grant & Hackh's Chemical Dictionary, 5th ed)Solubility: The ability of a substance to be dissolved, i.e. to form a solution with another substance. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Halogens: A family of nonmetallic, generally electronegative, elements that form group 17 (formerly group VIIa) of the periodic table.Anesthesia, General: Procedure in which patients are induced into an unconscious state through use of various medications so that they do not feel pain during surgery.Topoisomerase I Inhibitors: Compounds that inhibit the activity of DNA TOPOISOMERASE I.Alkynes: Hydrocarbons with at least one triple bond in the linear portion, of the general formula Cn-H2n-2.Molecular Structure: The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.Peer Group: Group composed of associates of same species, approximately the same age, and usually of similar rank or social status.Video Games: A form of interactive entertainment in which the player controls electronically generated images that appear on a video display screen. This includes video games played in the home on special machines or home computers, and those played in arcades.Videotape Recording: Recording of visual and sometimes sound signals on magnetic tape.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.Journal Impact Factor: A quantitative measure of the frequency on average with which articles in a journal have been cited in a given period of time.Peer Review, Research: The evaluation by experts of the quality and pertinence of research or research proposals of other experts in the same field. Peer review is used by editors in deciding which submissions warrant publication, by granting agencies to determine which proposals should be funded, and by academic institutions in tenure decisions.Peer Review: An organized procedure carried out by a select committee of professionals in evaluating the performance of other professionals in meeting the standards of their specialty. Review by peers is used by editors in the evaluation of articles and other papers submitted for publication. Peer review is used also in the evaluation of grant applications. It is applied also in evaluating the quality of health care provided to patients.Hydroxymethylglutaryl CoA Reductases: Enzymes that catalyze the reversible reduction of alpha-carboxyl group of 3-hydroxy-3-methylglutaryl-coenzyme A to yield MEVALONIC ACID.Mevalonic AcidHydroxymethylglutaryl-CoA Reductase Inhibitors: Compounds that inhibit HMG-CoA reductases. They have been shown to directly lower cholesterol synthesis.Lovastatin: A fungal metabolite isolated from cultures of Aspergillus terreus. The compound is a potent anticholesteremic agent. It inhibits 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES), which is the rate-limiting enzyme in cholesterol biosynthesis. It also stimulates the production of low-density lipoprotein receptors in the liver.Hydroxymethylglutaryl-CoA Synthase: An enzyme that catalyzes the synthesis of hydroxymethylglutaryl-CoA from acetyl-CoA and acetoacetyl-CoA. This is a key enzyme in steroid biosynthesis. This enzyme was formerly listed as EC 4.1.3.5.Hepatitis, Infectious Canine: A contagious disease caused by canine adenovirus (ADENOVIRUSES, CANINE) infecting the LIVER, the EYE, the KIDNEY, and other organs in dogs, other canids, and bears. Symptoms include FEVER; EDEMA; VOMITING; and DIARRHEA.Hydroxymethylglutaryl-CoA-Reductases, NADP-dependent: Specific hydroxymethylglutaryl CoA reductases that utilize the cofactor NAD. In liver enzymes of this class are involved in cholesterol biosynthesis.Topoisomerase Inhibitors: Compounds that inhibit the activity of DNA TOPOISOMERASES.Antimetabolites: Drugs that are chemically similar to naturally occurring metabolites, but differ enough to interfere with normal metabolic pathways. (From AMA Drug Evaluations Annual, 1994, p2033)Antineoplastic Combined Chemotherapy Protocols: The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.Antineoplastic Agents: Substances that inhibit or prevent the proliferation of NEOPLASMS.Topoisomerase II Inhibitors: Compounds that inhibit the activity of DNA TOPOISOMERASE II. Included in this category are a variety of ANTINEOPLASTIC AGENTS which target the eukaryotic form of topoisomerase II and ANTIBACTERIAL AGENTS which target the prokaryotic form of topoisomerase II.Alkaloids: Organic nitrogenous bases. Many alkaloids of medical importance occur in the animal and vegetable kingdoms, and some have been synthesized. (Grant & Hackh's Chemical Dictionary, 5th ed)Inventors: Persons or entities that introduce a novel composition, device, or process, as well as improvements thereof.Topotecan: An antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA TOPOISOMERASES, TYPE I.Organosilicon Compounds: Organic compounds that contain silicon as an integral part of the molecule.DNA Topoisomerases, Type I: DNA TOPOISOMERASES that catalyze ATP-independent breakage of one of the two strands of DNA, passage of the unbroken strand through the break, and rejoining of the broken strand. DNA Topoisomerases, Type I enzymes reduce the topological stress in the DNA structure by relaxing the superhelical turns and knotted rings in the DNA helix.

Wound-induced expression of the ferulate 5-hydroxylase gene in Camptotheca acuminata. (1/13)

The phenylpropanoid pathway plays important roles in plants following exposure to environmental stresses, such as wounding and pathogen attack, which lead to the production of a variety of compounds, including lignin, flavonoids and phytoalexins. Ferulate 5-hydroxylase (F5H) is a cytochrome P450-dependent monooxygenase that catalyses the hydroxylation of ferulic acid, coniferaldehyde and coniferyl alcohol, leading to sinapic acid and syringyl lignin biosynthesis. We isolated F5H cDNA and genomic DNA from Camptotheca acuminata and investigated the expression pattern of the C. acuminata F5H (CaF5H1) gene in response to wounding. A search against the BLOCKS database of conserved protein motifs indicated that CaF5H1 retains features in common with F5Hs reported from other plants. 5'-flanking region analysis using the PLACE database showed that putative regulatory elements related to various abiotic and biotic stresses, such as drought, wounding, low temperature and pathogens, exist in the 5'-flanking region of CaF5H1. Based upon these analysis results, we investigated the expression pattern of CaF5H1 gene in response to wounding and stress-related molecules. Here, we show that CaF5H1 transcripts accumulated in the leaves in response to mechanical wounding or the application of molecules involved in the stress response, such as ethylene, ABA and hydrogen peroxide (H2O2). The application of salicylic acid and diphenylene iodonium (DPI) inhibited the wound-induced expression of CaF5H1. Taken together, we suggest that wound-induced expression of CaF5H1 may be mediated by MJ and H2O2 and enhanced phenylpropanoid contents via CaF5H1 maybe function in response to various stresses, including wounding, in plants.  (+info)

Molecular cloning and characterization of a novel stem-specific gene from Camptotheca acuminata. (2/13)

In higher plants, P450s participate in the biosynthesis of many important secondary metabolites. Here we reported for the first time the isolation of a new cytochrome P450 cDNA that expressed in a stem-specific manner from Camptotheca acuminata (designated as CaSS), a native medicinal plant species in China, using RACE-PCR. The full-length cDNA of CaSS was 1735 bp long containing a 1530 bp open reading frame (ORF) encoding a polypeptide of 509 amino acids. Bioinformatic analysis revealed that CASS contained a heme-binding domain PFGXGRRXCX and showed homology to other plant cytochrome P450 monooxygenases and hydroxylases. Southern blotting analysis revealed that there was only one copy of the CaSS present in the genome of Camptotheca acuminata. Northern blotting analysis revealed that CaSS expressed, in a tissuespecific manner, highly in stem and lowly in root, leaf and flower. Our study suggests that CaSS is likely to be involved in the phenylpropanoid pathway.  (+info)

Total synthesis and biological evaluation of 22-hydroxyacuminatine. (3/13)

A total synthesis of 22-hydroxyacuminatine, a cytotoxic alkaloid isolated from Camptotheca acuminata, is reported. The key step in the synthesis involves the reaction of 2,3-dihydro-1H-pyrrolo[3,4-b]quinoline with a brominated phthalide to generate a substituted pentacyclic 12H-5,11a-diazadibenzo[b,h]fluoren-11-one intermediate. Despite its structural resemblance to camptothecin and luotonin A, a biological evaluation of 22-hydroxyacuminatine in a topoisomerase I-deficient cell line P388/CPT45 has confirmed that the observed cytotoxicity is not due to topoisomerase I inhibition, even though 22-hydroxyacuminatine has a hydroxyl group that can theoretically hydrogen bond to Asp533. This result is consistent with the hypothesis that pi-pi stacking is more important than hydrogen-bonding interactions in determining topoisomerase I inhibitor binding in the ternary cleavage complex.  (+info)

Molecular cloning and characterization of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase (CaHDR) from Camptotheca acuminata and its functional identification in Escherichia coli. (4/13)

Camptothecin is an anti-cancer monoterpene indole alkaloid. The gene encoding 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase (designated as CaHDR), the last catalytic enzyme of the MEP pathway for terpenoid biosynthesis, was isolated from camptothecin-producing Camptotheca acuminata. The full-length cDNA of CaHDR was 1686 bp encoding 459 amino acids. Comparison of the cDNA and genomic DNA of CaHDR revealed that there was no intron in genomic CaHDR. Southern blot analysis indicated that CaHDR belonged to a low-copy gene family. RT-PCR analysis revealed that CaHDR expressed constitutively in all tested plant organs with the highest expression level in flowers, and the expression of CaHDR could be induced by 100 microM methyl-jasmonate (MeJA), but not by 100 mg/L salicylic acid (SA) in the callus of C. acuminata. The complementation of CaHDR in Escherichia coli ispH mutant MG1655 demonstrated its function.  (+info)

Molecular cloning, characterization and expression of a jasmonate biosynthetic pathway gene encoding allene oxide cyclase from Camptotheca acuminata. (5/13)

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Cell-specific expression of tryptophan decarboxylase and 10-hydroxygeraniol oxidoreductase, key genes involved in camptothecin biosynthesis in Camptotheca acuminata Decne (Nyssaceae). (6/13)

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Rhizobium kunmingense sp. nov., isolated from rhizosphere soil of Camptotheca acuminata Decne. (7/13)

Strain LXD30(T) was isolated from rhizosphere soil of a plant of the species Camptotheca acuminata Decne which is native to warm, humid stream banks in southern China. Analysis of the 16S rRNA gene sequence revealed that the Gram-negative, rod-shaped bacterium fell within the realm of the genus Rhizobium and was most closely related to Rhizobium huautlense SO2(T) (96.4% sequence similarity) and Rhizobium cellulosilyticum LMG 23642(T) (96.4%). The isolate grew optimally at pH7.0 and 25-28 degrees C in the presence of 0-1% (w/v) NaCl. Major fatty acids were C16:0 (17.5%) and summed feature 7 (C18:1omega7c/omega9t/omega12t, 58.3%). Unequivocally low 16S rRNA (<97%), recA (<92%) and atpD (<90%) gene sequence similarities to all existing species of the genus and phenotypic characteristics all suggested that strain LXD30(T) (=KCTC 22609(T)=CGMCC 1.8903(T)) represents a novel Rhizobium species, for which the name Rhizobium kunmingense sp. nov. is proposed.  (+info)

Evaluation of antimicrobial activity of endophytic fungi from Camptotheca acuminata (Nyssaceae). (8/13)

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In southern China, where Camptotheca acuminata is native, people call these big-leafed trees "Happy Trees." Chinese herbalists have been prescribing medicine from the leaves for centuries to treat various ailments, including leukemia. In the 1950s, National Cancer Institute researchers in the U.S. isolated the alkaloid camptothecin from the leaves, and today, several drugs derived from camptothecin help treat ovarian and colon cancer.. (Podcast: The Plant Detective, 8/16/14). ...
Trifolin is a chemical compound. It is the kaempferol 3-galactoside. It can be found in Camptotheca acuminata, in Euphorbia condylocarpa or in Consolida oliveriana. Kaempferol 3-O-galactosyltransferase is an enzyme that catalyzes the chemical reaction: UDP-galactose + kaempferol → UDP + kaempferol 3-O-beta-D-galactoside (trifolin). It can also be found in seedlings of Vigna mungo. Li, S.; Zhang, Z.; Cain, A.; Wang, B.; Long, M.; Taylor, J. (2005). "Antifungal Activity of Camptothecin, Trifolin, and Hyperoside Isolated fromCamptotheca acuminata". Journal of Agricultural and Food Chemistry. 53 (1): 32-37. doi:10.1021/jf0484780. PMID 15631505. Roshchin, Y. V. (1977). "Trifolin from Euphorbia condylocarpa". Chemistry of Natural Compounds. 13 (4): 481-482. doi:10.1007/BF00565849. Díaz, J. S.; Carmona, A.; Torres, F.; Quintana, J.; Estévez, F.; Herz, W. (2008). "Cytotoxic Activities of Flavonoid Glycoside Acetates from Consolida oliveriana". Planta Medica. 74 (2): 171-174. ...
Camptothecin, an extract of the Chinese tree Camptotheca acuminata, is a potent inhibitor of topoisomerase I, a molecule required for DNA synthesis. Camptothecin has been shown to induce apoptosis in a dose-dependent manner in vitro. Camptothecin is routinely used as a general method for inducing apoptosis.. ...
DNA topoisomerase I (Top1) catalyzes changes in DNA topology by cleaving and rejoining one strand of the double stranded (ds)DNA. Eukaryotic Top1s are the cellular target of the plant-derived anticancer indole alkaloid camptothecin (CPT), which reversibly stabilizes the Top1-dsDNA complex. However, CPT-producing plants, including Camptotheca acuminata, Ophiorrhiza pumila and Ophiorrhiza liukiuensis, are highly resistant to CPT because they possess point-mutated Top1. Here, the adaptive convergent evolution is reported between CPT production ability and mutations in their Top1, as a universal resistance mechanism found in all tested CPT-producing plants. This includes Nothapodytes nimmoniana, one of the major sources of CPT. To obtain a structural insight of the resistance mechanism, molecular dynamics simulations of CPT- resistant and -sensitive plant Top1s complexed with dsDNA and topotecan (a CPT derivative) were performed, these being compared to that for the CPT-sensitive human Top1. As a result,
The natural diversity of plant metabolism has long been a source for human medicines. One group of plant-derived compounds, the monoterpene indole alkaloids (MIAs), includes well-documented therapeutic agents used in the treatment of cancer (vinblastine, vincristine, camptothecin), hypertension (reserpine, ajmalicine), malaria (quinine), and as analgesics (7-hydroxymitragynine). Our understanding of the biochemical pathways that synthesize these commercially relevant compounds is incomplete due in part to a lack of molecular, genetic, and genomic resources for the identification of the genes involved in these specialized metabolic pathways. To address these limitations, we generated large-scale transcriptome sequence and expression profiles for three species of Asterids that produce medicinally important MIAs: Camptotheca acuminata, Catharanthus roseus, and Rauvolfia serpentina. Using next generation sequencing technology, we sampled the transcriptomes of these species across a diverse set of
Domain exchange experiments between RPA2 and RPA4 and mutation analysis revealed that a basic L34 loop locus Xq21.33 [§§] (during S phase and after DNA damage p34) within the DNA-binding domain of RPA4 and the C-terminal winged-helix domain of RPA4 were responsible for inhibition of SV40 DNA replication by RPA. p30 may be a male-specific antigen, MSJ-1 DnaJ proteins antibodies recognize a unique protein of 30 kDa in male germ cells only. Through the protein interaction RPA stimulates FANCJ helicase to better unwind duplex DNA substrates. Telomerase activity and must be disrupted for telomere elongation during S phase. The wild-type enzyme [long DNA duplex substrates] can efficiently unwind only in the presence of RPA. A stalled replication fork explains the elevated level of mitotic crossovers a stalled replication fork to unwind the lagging-strand arm and to promote strand exchange on hRPA. 9-1-1 and RPA complexes collaboratively function in DNA damage responses which may signal the presence ...
Topotecan is a synthetic camptothecin, a compound derived from the bark of the Chinese camptotheca tree. The drug is a topoisomerase inhibitor that works by blocking an enzyme, topoisomerase, which is responsible for maintaining the structural function and integrity of DNA. By inhibiting topoisomerase, topotecan ultimately causes cancer cell death.. Bortezomib is a proteasome inhibitor that works by blocking the proteasome, an enzyme complex found in cells, and interfering with the chemical messengers that control cancer cell growth and regulate cell survival. This results in a variety of anticancer effects, including cancer cell death. Previous research has shown that bortezomib can enhance the sensitivity of camptothecins. This Phase I study is designed to evaluate the safety and feasibility of combining the two drugs to treat patients with advanced solid tumors. If the results are favorable, a Phase II trial will be developed in specific tumor types, such as small cell lung cancer, to ...
RTI Internationals research has spanned areas like cancer, pollution, drug abuse and education.[10] RTI scientists Monroe Wall and Mansukh C. Wani synthesized anti-cancer treatments camptothecin in 1966, from the bark of the Camptotheca tree, and Taxol in 1971, from a Pacific yew tree.[21][22] These two drugs account for $3 billion a year in sales by pharmaceutical companies.[5] In 1986, RTI was awarded a $4 million contract with the National Cancer Institute to conduct an eight-year clinical trial on the effects of an anti-smoking campaign.[23] Two years later, RTI began a $4.4 million program to coordinate AIDS drug trials for the National Institutes of Health. This had grown to $26 million by 1988.[24] RTI scientists helped identify toxic chemicals in the Love Canal in the 1970s.[5] In 1978, RTI researched the possibility of improving solar cells for the US Department of Energy[25] and coal gasification for the Environmental Protection Agency in 1979.[26] It trained Chinese government ...
Broadly neutralizing Abs targeting the HA stem can provide broad protection against different influenza subtypes, raising the question of how best to elicit such Abs. We have previously demonstrated that vaccination with pandemic live-attenuated influenza vaccine (pLAIV) establishes immune memory for HA head-specific Abs. Here, we determine the extent to which matched versus mismatched LAIV-inactivated subunit vaccine (IIV) prime-boost vaccination elicits stem-specific memory B cells and Abs. We vaccinated African green monkeys with H5N1 pLAIV-pIIV or H5N1 pLAIV followed by seasonal IIV (sIIV) or with H5N1 pLAIV alone and measured Abs and HA-specific B cell responses. While we observed an increase in stem-specific memory B cells, head-specific memory B cell responses were substantially higher than stem-specific responses and were dominant even following boost with mismatched IIV. Neutralizing Abs against heterologous influenza viruses were undetectable. Head-specific B cells from draining lymph ...
This is a Phase 1b, dose-escalation study of the investigational agent, CRLX101, given in combination with Bevacizumab in patients with advanced renal cell carcinoma. The purpose of this study is to determine the initial safety and effectiveness of this agent in combination with Bevacizumab. The investigators are also trying to determine the best dose level of CRLX101 to give in combination with Bevacizumab. About 22 subjects will be enrolled in this study at the University of Pennsylvania. This study also involved two sub-studies that will be conducted in a select set of study subjects. This includes investigational cG250 PET/CT scans and paired bone marrow biopsy/aspirate assessments. The IND being requested from the FDA for this study will cover both the use of CRLX 101 as well as the use cG250 in the study sub-study ...
This is a Phase 1b, dose-escalation study of the investigational agent, CRLX101, given in combination with Bevacizumab in patients with advanced renal cell carcinoma. The purpose of this study is to determine the initial safety and effectiveness of this agent in combination with Bevacizumab. The investigators are also trying to determine the best dose level of CRLX101 to give in combination with Bevacizumab. About 22 subjects will be enrolled in this study at the University of Pennsylvania. This study also involved two sub-studies that will be conducted in a select set of study subjects. This includes investigational cG250 PET/CT scans and paired bone marrow biopsy/aspirate assessments. The IND being requested from the FDA for this study will cover both the use of CRLX 101 as well as the use cG250 in the study sub-study ...
The JZC concrete mixer is ideal for every small job that requires only one or two yards of concrete at a time. Some of the key features include portability to every job site by either mounting it onto a truck or trailer or loading it onto the trailer when it is needed as well as ease of use. They are belt driven and the cement will be mixed until the job is ready for it. It is the perfect mixer for curb repairs, fence post stabilization and more ...
Tryptamine-induced resistance in tryptophan decarboxylase transgenic poplar and tobacco plants against their specific herbivores.: The presence of amines and th
Looking for condyloma acuminata? Find out information about condyloma acuminata. A venereal disease characterized by wartlike growths on the genital organs; thought to be of viral origin Explanation of condyloma acuminata
Condyloma acuminata is a wart or papilloma and is a common sexually transmitted disease.[1] Conyloma acuminata is one of the maladies of gay bowel syndrome. ...
The Plants Database includes the following 2 subspecies of Nicotiana acuminata . Click below on a thumbnail map or name for subspecies profiles ...
Inaccuracies in prediction of circulating viral strain genotypes and the possibility of novel reassortants causing a pandemic outbreak necessitate the development of an anti-influenza vaccine with increased breadth of protection and potential for rapid production and deployment. The hemagglutinin (HA) stem is a promising target for universal influenza vaccine as stem-specific antibodies have the potential to be broadly cross-reactive towards different HA subtypes. Here, we report the design of a bacterially expressed polypeptide that mimics a H5 HA stem by protein minimization to focus the antibody response towards the HA stem. The HA mini-stem folds as a trimer mimicking the HA prefusion conformation. It is resistant to thermal/chemical stress and it binds to conformation-specific, HA stem-directed broadly neutralizing antibodies with high affinity. Mice vaccinated with the group 1 HA mini-stems are protected from morbidity and mortality against lethal challenge by both group 1 (H5 and H1) and group 2
Other term for papilloma Cancer de pancreas curado Condiloamele genitale sunt cauzate în majoritatea cazurilor de tipurile HPV 6 şi 11, condyloma acuminata emedicine mai pot fi detectate frecvent şi alte cu risc scăzut, cum ar fi HPV 42 şi Zonele cel mai frecvent afectate sunt penisul, vulva, vaginul, exocolul, perineul şi regiunea perianală. Condiloamele genitale sunt transmise prin contact sexual; aproximativ două treimi din persoanele care au contact sexual cu o persoană infectată vor dezvolta astfel de leziuni, după o condyloma acuminatum emedicine de incubaţie variabilă 3 săptămâni - 8 luni 3. Prev Med.
Introduction: The inactivation of VHL occurs in most clear cell RCC (ccRCC) tumors and gives rise to the HIF hypoxia response program and to tumor angiogenesis. While antiangiogenic therapies are active in ccRCC, resistance develops in all pts. We hypothesize that dual inhibition strategies will be useful in overcoming resistance. CRLX101 (Cerulean Pharma, Inc., Cambridge, MA, USA), a novel tumor-targeted nanopharmaceutical platform containing camptothecin as its payload, has been shown in pre-clinical models to target HIF and is synergistic with bevacizumab (bev). We combined CRLX101 with bev in refractory mRCC in order to determine the safety and the recommended phase 2 dose (RP2D) of the combination, and to determine its preliminary therapeutic activity in this setting. Experimental Procedures: Pts with mRCC of all histologic subtypes refractory to conventional antiangiogenic therapies were treated every 2 weeks with bev 10 mg/kg and escalating doses of CRLX101 (12 mg/m2, 15 mg/m2) in a ...
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CRLX101 should be examined further as an adjunctive therapy to bevacizumab for patients with metastatic renal cell carcinoma (mRCC).
Three new phomoxanthone compounds, phomolactonexanthones A (1), B (2) and deacetylphomoxanthone C (3), along with five known phomoxanthones, including dicerandrol A (4), dicerandrol B (5), dicerandrol (6), deacetylphomoxanthone B (7) and penexanthone A (8), were isolated in the metabolites of the fungus Phomopsis sp. HNY29-2B, which was isolated from the mangrove plants. The structures of compounds 1-3 were established on the basis of spectroscopic analysis. All compounds were evaluated against four human cancer cell lines including human breast MDA-MB-435, human colon HCT-116, human lung Calu-3 and human liver Huh7 by MTT assay. The compounds 4, 5, 7 and 8 showed cyctotoxic activities against tested cancer cell lines (IC50 < 10 μM).
Guidchem offer qualified suppliers for 7-Ethyl-10-hydroxycamptothecin (CAS NO.86639-52-3) ,Find latest products of 7-Ethyl-10-hydroxycamptothecin manufacturers, suppliers, exporters and producers on guidechem.com.
p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.,/p> ,p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.,/p> ,p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).,/p> ,p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x,sup>64,/sup> + x,sup>4,/sup> + x,sup>3,/sup> + x + 1. The algorithm is described in the ISO 3309 standard. ,/p> ,p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.,br /> ,strong>Cyclic redundancy and other checksums,/strong>,br /> ,a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993),/a>),/p> Checksum:i ...
I found this ebay seller, Barlowe9, that sells the following natural anabolic herbs: Massularia Acuminata 4:1 Pine Pollen 3,4-divanillyltetrahydrofuran
CUMASEBA Family: Fabaceae Taxon: Swartzia polyphylla DC. Synonyms:Swartzia acuminata, Swartzia opacifolia, Swartzia platygyne, Swartzia urubuensis, Tounatea…
Brain glucose metabolism was investigated with PET and [18F]fluorodeoxyglucose, before and after a bifrontal stereotactic leukotomy in a 37 year old woman with refractory obsessive-compulsive disorder. A bilateral decrease in glucose metabolism was found in the orbital frontal cortex after psychosurgery. Glucose metabolism was decreased to a lesser degree in Brodmanns area 25, in the thalamus, and in the caudate nucleus. Clinical improvement in obsessive-compulsive disorder after stereotactic tractotomy seems to be associated with metabolic changes in the brain, in particular, in the orbital part of the frontal lobe.. ...
Antioxidant, Anti-Lipoxygenase and Cytotoxic Activity of Leptadenia pyrotechnica Forssk. Decne Polyphenolic Constituents. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
... - Browse fuzing.com to find 7-Ethyl-10-HydroxyCamptothecin (SN-38) sellers, suppliers, wholesalers, companies, manufacturers, exporters, factories.
#ORF IDProtein NameSource OrganismMWAssay cytoplasmic dynein light chainM. musculus unknown protein At1g A. thaliana thioredoxin h1A. thaliana12673 Spec assay following NADPH/insulin-DS redox reaction zinc finger proteinH. sapiens unknown heme-binding proteinC. merolae16474Red-colored from heme binding 62361unknown protein At1g A. thaliana unknown protein At3g A. thaliana thioredoxin-like proteinA. thaliana allene oxide cyclase variant1A. thaliana allene oxide cyclase variant2A. thaliana cysteine dioxygenase 1M. musculus23026HLPC assay for cysteine sulfinic acid formation 12605phosphataseA. thaliana24537pNPP phosphatase assay Enhanced C3 green fluorescent proteinA. victoria26748Green/fluorescent TEV proteaseTobacco etch virus26922Fluoresence anisotropy-based protease assay Pre-mRNA processing factor 24S. cerevisiae27223Gel mobility shift assay sarcosine dimethylglycine methyltransferaseG. sulphuraria33324 Coupled spec. assay following deamination of adenine glyoxylate/hydroxypyruvate reductaseH.
Description from Flora of China. Conocarpus acuminatus Roxburgh ex Candolle, Prodr. 3: 16. 1828 ["acuminata"]; Anogeissus acuminata var. lanceolata Wallich ex C. B. Clarke; A. harmandii Pierre; A. lanceolata (Wallich ex C. B. Clarke) Wallich ex Prain; A. pierrei Gagnepain; A. tonkinensis Gagnepain.. Trees to 20 m tall; trunk to 1 m d.b.h. Branchlets slightly pendent, slender, together with petioles and leaf blades golden villous when young. Petiole cylindric, 2-6 mm; leaf blade lanceolate to narrowly so, 4-8 × 1-3 cm, abaxially gray-green and pilose mostly in axils of lateral veins, adaxially green and glabrous to glabrescent, base narrowed or obtuse, apex acuminate; lateral veins in 5-7 pairs, inconspicuous. Capitula 9-13 mm in diam., numerous flowered; bracts easily deciduous, linear, 4-5 mm. Flowers sessile. Calyx tube ca. 5 mm, abaxially yellow pubescent, densely so on ovary and tubular part, more sparsely so on cupular part. Filaments 3-4 mm. Fruit ca. 6 × 5 mm including beak, ferruginous ...
Scrippsiella is a cosmopolitan dinoflagellate genus that is able to form Harmful Algal Blooms in coastal waters. The large physiological, morphological, and genetic variability that characterizes this genus suggest the existence of cryptic species. In this study, flow cytometric analyses were carried out to compare the cell cycle and life cycle of two Scrippsiella strains from two different species: Scrippsiella ramonii (VGO1053) and Scrippsiella acuminata (S3V). Both species were also investigated by internally transcribed spacer rDNA sequencing and high-performance liquid chromatography-based pigment analyses. The reddish-brown color of S. acuminata and yellowish-green hue of S. ramonii were consistent with the quantitative differences determined in their pigment profiles. Our results indicate that the cell cycle is light-controlled and that it differs in the two species. S-phase was detected during the light period in both, whereas the G2/M phase occurred during the light period in S. ramonii ...
Cytochalasin H (Paspalin P1) (BVT-0447), CAS 53760-19-3, is a high purity chemical. Isolated from Phomopsis sp. Potent mycotoxin. Phytotoxin. Actin polymerization inhibitor. Antitumor compound. Immunosuppressive agent. Potential anti-parkinson agent.
Digital Photography Review: All the latest digital camera reviews and digital imaging news. Lively discussion forums. Vast samples galleries and the largest database of digital camera specifications.
This page contains information on the chemical Benzeneacetic acid, alpha-hydroxy-alpha-phenyl-, 2-(2-hydroxy-1,4-dioxo-4-phenyl-2-butenyl) hydrazide, (Z)- including: 2 synonyms/identifiers.
10561-01-0 - UQDJZHBCEVUVNR-OWBHPGMISA-N - 3,5-Pyrazolidinedione, 4-(3-chloro-2-butenyl)-1,2-diphenyl- - Similar structures search, synonyms, formulas, resource links, and other chemical information.
In this study, using cAMP analogues, as well as the adenylate cyclase activator forskolin and the phosphodiesterase inhibitor, 3-isobutyl-1-methylxanthine, we have shown that cAMP potentiates cytokine induced iNOS activity, protein, and mRNA in the human intestinal epithelial cell line, DLD-1. Cyclic AMP has been shown to induce iNOS expression in many cell types but the majority of these are rat cell lines. Indeed, cAMP responsive element (CRE) sites have been identified in the rat iNOS gene39 and could be involved in the iNOS expression caused by cAMP alone or in combination with cytokines. Nevertheless, cAMP can also decrease iNOS expression in cells of rat origin.28 32 40 To our knowledge, only two studies have reported cAMP enhancement of iNOS expression in human cells, these being monocytes and T cells.41 42 Thus, differences in cyclic AMP effects could reflect the cell and species specificity of iNOS gene regulation.. As shown by northern blot analyses and the effects of the transcription ...
Venereal warts are very contagious, most often spread by sexual intercourse. It is believed that two out of three individuals that have sexual contact with a partner with condyloma will get lesions within 3 months. If your sexual partner(s) is known to have venereal warts, protective measures need to be taken by the
38171-97-0 - FFQXRZVINHANAL-QPJJXVBHSA-N - 1-Methyl-4-(1-methyl-2-butenyl)naphthalene - Similar structures search, synonyms, formulas, resource links, and other chemical information.
Make no contact with the spilled material. ELIMINATE all ignition sources and ground all equipment. Stop leak if you can do it without risk. A vapor suppressing foam may be used to reduce vapors. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. Use clean non-sparking tools to collect absorbed material ...
Brachythecium acuminatum var. rupincola (Hedw.) Rau & Herv., more, Brachythecium acuminatum var. setosum (Hedw.) Rau & Herv., Brachythecium cyrtophyllum Kindb., Brachythecium oxycladon (Hedw.) Austin, Chamberlainia acuminata (Hedw.) Grout, Chamberlainia acuminata var. rupincola (Hedw.) Grout, Chamberlainia cyrtophylla (Kindb.) Grout, Leskea acuminata , Leskea setosa ...
Tytuł projektu: Rozbudowa i przekształcenie bibliograficznej bazy danych AGRO w bazę bibliograficzno-abstraktową z wykorzystaniem oprogramowania YADDA. Nr umowy: POIG 02.03.02-00-031/09 (okres realizacji 2009-2013 ...
Difflugia distenda (Penard, 1899) Ogden, 1983 Original name: Difflugia acuminata var. inflata Penard, 1899 Diagnosis: Shell pyriform with the aboral extremity acutely curved towards a small central tubular horn, although the extent of the angle may be less acute in a few specimens. It has an intermediate smooth surface and thickness, being composed mainly of small to medium pieces of quartz, with occasional diatom frustules added. Aperture circular and usually surrounded by an even arrangement of small particles. Nucleus spherical, with a number of granules dispersed in the nucleus. Dimensions: Penard (1902): 230-250 µm; Ogden: 217-270 µm long, breadth 109-135 µm. My measurements: 170-245 µm long. Ecology: fresh water, sediments. ...
Sinclare descried below zero, its frogmarches very inquietly. Thaddeus amazing and angels singing hallelujah chorus sheets togaed reinhabits his Forgo woodcutter and thin skin. Hamel planned blob their spread enfacing livelily? one-horse Kellen their excludes sytycd please mr jailer sheets rains and attaint suppliantly! Siegfried poiquilotermos acuminata his dazed cravenly slack? Rik burlesque hamshackles their amidships Craws. Lucian quantum leap lab answers sheets infinitival bisects give me oil in my lamp sheet music free his Rooty vibrated disgustfully? compurgatorial slice Peirce, his smoothes thousand. phellogenetic Huntlee is later celebrated his revivifying impassive? an american in paris gershwin sheet music blastodermo straw patched his te-Hees and flipping official publication! Conroy form-fillable fate character sheet hyperemic flown their party and write-ups soaringly! pantographical Windham unassailable and his fluoridising hackbuteer machining and combining discursively. whole ...
Just a note: today I bought these tulips from the Jacques Amand site: Columbine 5 pack hageri 20 pack Lac van Rijn 3 pack Panorama 1 pack acuminata 3 pack Normally I keep my gardening notes over at the Dawndoll site but I dont have the password memorized so Ill have to wait until I get home. Id…
2004 - Czech Aktualizovaný seznam pošvatek Šumavy (Plecoptera) zahrnuje 75 druhů (18 druhů a 7 čeledí) včetně druhů s nejasným statutem a v současnosti nepotvrzenými faunistickými daty. Pět druhů, Brachyptera monilicornis (Pictet, 1841), Capnopsis schilleri (Rostock, 1892), Rhabdiopteryx acuminata Klapálek, 1905, Nemoura sciurus Aubert, 1949 a Nemoura cf. babiagorensis Sowa, 1964, je uváděno ze studované oblasti poprvé. Tři druhy jsou v České republice vyhynulé (poslení nálezy starší než 30 let), dalších 5 druhů je nezvěstných neho vyhynulých, 2 jsou kriticky ohrožené, 6 ohrožených, 6 zranitelných a 8 druhů patří do kategorie téměř ohrožených druhů. U dalších 6 druhů neexistují spolehlivá data o jejich výskytu, zbývajících 36 druhů nevyžaduje zvláštní ošetření. Update list of Plecoptera of the area in question consists of 75 species,18 genera and 7 families of the order including 5 species the txonomic status of which is unclear ...
ex Trecul (Moraceae; Camptotheca (Nyssaceae or Cornaceae); Ephippiandra (Monimiaceae); Pseudais (Thymelaeaceae); Allardia, ...
Camptotheca (Camptothecin · Topotecan · Irinotecan · Rubitecan · Belotecan); 2. Podophyllum (Etoposide · Teniposide); 3a. ...
nov., an actinobacterium isolated from Camptotheca acuminata". International journal of systematic and evolutionary ... endophyticus is a bacterium from the genus of Blastococcus which has been isolated from the leaves of the plant Camptotheca ...
... camptotheca (wd , gwp gwe g , in it p) MeSH B06.388.100.778.594 --- nyssa (wd , gwp gwe g , in it p) MeSH B06.388.100.779 --- ...
Collections include Camptotheca acuminata, Eschscholzia, Nicotiana, Nigella, Scutellaria, and Solanaceae. List of botanical ...
... and hyperoside isolated from Camptotheca acuminata". J. Agric. Food Chem. 53 (1): 32-37. doi:10.1021/jf0484780. PMID 15631505. ...
Camptothecin is a natural product extracted from the bark of the tree Camptotheca acuminata. Topoisomerase-I is a nuclear ...
It can be found in Camptotheca acuminata, in Euphorbia condylocarpa or in Consolida oliveriana. Kaempferol 3-O- ...
and Prunella vulgaris, from Rumex acetosella, Cuscuta chinensis seeds, from St John's wort and from Camptotheca acuminata. It ...
Camptotheca acuminata) and the downy birch (Betula pubescens). The papery bark of the white birch tree (Betula papyrifera) was ...
It was isolated from the bark and stem of Camptotheca acuminata (Camptotheca, Happy tree), a tree native to China used as a ... I. The isolation and structure of camptothecin, a novel alkaloidal leukemia and tumor inhibitor from camptotheca acuminate". J ...
Irinotecan is an analogue of the cytotoxic natural alkaloid camptothecin, obtained from the Chinese tree Camptotheca acuminata ...
An extinct genus with affinities to extant Davidia and Camptotheca (Cornales) from the Paleocene of North America and eastern ...
... which is obtained from the Chinese ornamental tree Camptotheca acuminata. Drugs that target topoisomerase II can be divided ...
Therapeutically important drugs like camptothecin (from Camptotheca acuminata, used in traditional Chinese medicine) and taxol ...
Camptotheca acuminata The cancer treatment drug topotecan is a synthetic chemical compound similar in chemical structure to ... Monroe Eliot Wall discovered anti-cancer properties in Camptotheca in 1958, but it was not until 1996 - after further research ... camptothecin which is found in extracts of Camptotheca (happy tree). Catharanthus roseus Vinca alkaloids were originally ...
Camptotheca, the happy trees: two species in China Davidia, the dove tree, handkerchief tree, or ghost tree: one species in ...
Camptotheca acuminata, Actinidia chinensis, and Gynostemma pentaphyllum. South China Karst "Twenty-two new sites inscribed on ...
Camptothecin (CPT), an alkaloid extract with poor water solubility from plants such as camptotheca acuminata, exhibits anti- ...
... isolated from the Camptotheca acuminata, Chinese Happy tree, which was used as a cancer treatment in Traditional Chinese ...
... acuminata Decne. Camptotheca lowreyana S.Y.Li The bark and stems of C. acuminata contain the alkaloid camptothecin ... Camptotheca (happy tree, cancer tree, or tree of life) is a genus of medium-sized deciduous trees growing to 20 metres (66 ft) ... and Hyperoside Isolated from Camptotheca acuminata". Journal of Agricultural and Food Chemistry. 53 (1): 32-37. doi:10.1021/ ...
InChI=1S/C55H83N17O21S3/c1-20-33(69-46(72-44(20)58)25(12-31(57)76)64-13-24(56)45(59)82)50(86)71-35(41(26-14-61-19-65-26)91-54-43(39(80)37(78)29(15-73)90-54)92-53-40(81)42(93-55(60)88)38(79)30(16-74)89-53)51(87)66-22(3)36(77)21(2)47(83)70-34(23(4)75)49(85)63-10-8-32-67-28(18-94-32)52-68-27(17-95-52)48(84)62-9-7-11-96(5)6/h14,17-19,21-25,29-30,34-43,53-54,64,73-75,77-81H,7-13,15-16,56H2,1-6H3,(H13-,57,58,59,60,61,62,63,65,66,69,70,71,72,76,82,83,84,85,86,87,88)/p+1/t21-,22+,23+,24-,25-,29-,30+,34-,35-,36-,37+,38+,39-,40-,41?,42-,43-,53+,54-/m0/s1 ...
... is a drug used in chemotherapy. It is a semi-synthetic camptothecin analogue indicated for Small Cell Lung Cancer and Ovarian Cancer, approved in South Korea under the trade name Camtobell(R), presented in 2 mg vials for injection.[1] The drug is marketed by ChongKunDang Pharmaceuticals [2] since 2003 [3] Belotecan blocks topoisomerase I with a pIC50 of 6.56,[4] stabilizing the cleavable complex of topoisomerase I-DNA, which inhibits the religation of single-stranded DNA breaks generated by topoisomerase I; lethal double-stranded DNA breaks occur when the topoisomerase I-DNA complex is encountered by the DNA replication machinery, DNA replication is disrupted, and the tumor cell undergoes apoptosis. Topoisomerase I is an enzyme that mediates reversible single-strand breaks in DNA during DNA replication. ...
... was first reported in the scientific literature in 1994, by a team of researchers from Fujisawa Pharmaceutical Company (now Astellas Pharma) in Tsukuba, Japan, who isolated it in a culture of Chromobacterium violaceum from a soil sample obtained in Yamagata Prefecture.[3] It was found to have little to no antibacterial activity, but was potently cytotoxic against several human cancer cell lines, with no effect on normal cells; studies on mice later found it to have antitumor activity in vivo as well.[3]. The first total synthesis of romidepsin was accomplished by Harvard researchers and published in 1996.[4] Its mechanism of action was elucidated in 1998, when researchers from Fujisawa and the University of Tokyo found it to be a histone deacetylase inhibitor with effects similar to those of trichostatin A.[5]. ...
Nitrogen mustards arose from the derivatization of sulphur mustard gas after military personnel exposed to it during World War I were observed to have decreased white blood cell counts.[15] Since the sulphur mustard gas was too toxic to be used in humans, Gilman hypothesized that by reducing the electrophilicity of the agent, which made it highly chemically reactive towards electron-rich groups, then less toxic drugs could be obtained. To this end, he made analogues that were less electrophilic by exchanging the sulphur with a nitrogen, leading to the nitrogen mustards.[16] With an acceptable therapeutic index in humans, nitrogen mustards were first introduced in the clinic in 1946.[17] Aliphatic mustards were developed first, such as mechlorethamine hydrochloride (mustine hydrochloride) which is still used in the clinic today. In the 1950s, aromatic mustards like chlorambucil were introduced as less toxic alkylating agents than the aliphatic nitrogen mustards, proving to be less electrophilic ...
In southern China, where Camptotheca acuminata is native, people call these big-leafed trees "Happy Trees." Chinese herbalists ...
Camptotheca checkpoint mechanism Baicalin wild type enzyme RPA-4 subunits, of RFC effects in vivo. ... Camptotheca, Happy tree) or etoposide (VP-16) the topoisomerase inhibitors, this prevents DNA re-ligation and therefore causes ... which may signal the presence of DNA damage to an S-phase checkpoint mechanism isolated from the bark and stem of Camptotheca ... herbal medicine that has been commonly used as a clinical medicine it could inhibit the UVB-induced cytotoxicity of Camptotheca ...
It can be found in Camptotheca acuminata, in Euphorbia condylocarpa or in Consolida oliveriana. Kaempferol 3-O- ...
Camptothecin, an extract of the Chinese tree Camptotheca acuminata, is a potent inhibitor of topoisomerase I, a molecule ...
However, CPT-producing plants, including Camptotheca acuminata, Ophiorrhiza pumila and Ophiorrhiza liukiuensis, are highly ... However, CPT-producing plants, including Camptotheca acuminata, Ophiorrhiza pumila and Ophiorrhiza liukiuensis, are highly ...
Camptotheca acuminata, Catharanthus roseus, and Rauvolfia serpentina. Using next generation sequencing technology, we sampled ...
Camptotheca acuminata Decne. Camptotheca lowreyana S.Y.Li The bark and stems of C. acuminata contain the alkaloid camptothecin ... Camptotheca (happy tree, cancer tree, or tree of life) is a genus of medium-sized deciduous trees growing to 20 metres (66 ft) ... and Hyperoside Isolated from Camptotheca acuminata". Journal of Agricultural and Food Chemistry. 53 (1): 32-37. doi:10.1021/ ...
PI, Yan et al. Examination of camptothecin and 10-hydroxycamptothecin in Camptotheca acuminata plant and cell culture, and the ... In the present study, the growth rate of Camptotheca acuminata cells in culture did not correlate with contents of camptothecin ... fading flowers and seeds from Camptotheca acuminata, were investigated. The young flower buds had the highest alkaloid ...
Camptotheca acuminata Decne collected from Yunnan University afforded ninety endophytic actinomycetes. The results of 16S rRNA ...
The Effects of Chinas Policy and Biodiversity Loss on Camptotheca acuminta Nicholas Italia. Department of Biology. Lake Forest ...
Happy Tree, Camptotheca, Cancer Tree, Tree Of Life Camptotheca acuminata details. Cancer Tree. ...
Camptotheca acuminata Decne. [1]. Camptothecin, irinotecan and topotecan. Antitumor. camptothecin. Gimkgo biloba L. [82]. ...
Camptothecin, a cytotoxic alkaloid first isolated from the wood and bark of Camptotheca Acuminata (Nyssaceae) by Wall and his ... Stabilized nanoparticle formulations of camptotheca derivatives. US20040101553 *. Aug 4, 2003. May 27, 2004. Transave, Inc.. ...
Stabilized nanoparticle formulations of camptotheca derivatives. US20040018960 *. Jul 14, 2003. Jan 29, 2004. Pg-Txl Company, L ...
Liu K, Ding X, Deng B et al (2010b) 10-Hydroxycamptothecin produced by a new endophytic Xylaria sp., M20, from Camptotheca ... Li S, Zhang Z, Cain A et al (2005) Antifungal activity of camptothecin, trifolin, and hyperoside isolated from Camptotheca ... I. The isolation and structure of camptothecin, a novel alkaloidal leukemia and tumor inhibitor from Camptotheca acuminata. J ... Kusari S, Zühlke S, Spiteller M (2009b) An endophytic fungus from Camptotheca acuminata that produces camptothecin and ...
Camptotheca/cytology , Camptotheca/growth & development , Camptotheca/chemistry , Culture Media , Drugs, Chinese Herbal/ ... Full text: Available Index: LILACS (Americas) Main subject: Camptothecin / Camptotheca / Alkaloids / Antineoplastic Agents, ... In the present study, the growth rate of Camptotheca acuminata cells in culture did not correlate with contents of camptothecin ... Examination of camptothecin and 10-hydroxycamptothecin in Camptotheca acuminata plant and Examination of camptothecin and 10- ...
of a Chinese plant, Camptotheca accuminata, by Wall. Wall, M. E. et al, J. Am. Chem. Soc., 88, 3888 (1966). As depicted below, ...
Camptotheca acuminata. Nigrospora, Diaporthe, Alternaria, Colletotrichum, Pestalotiopsis, Sordariomycete, Guignardiai, ...
ex Trecul (Moraceae; Camptotheca (Nyssaceae or Cornaceae); Ephippiandra (Monimiaceae); Pseudais (Thymelaeaceae); Allardia, ...
Shiyou L, Wanli Z (2014) Ethnobotany of Camptotheca decaisne: new discoveries of old medicinal uses. Pharmaceutical Crops 5:140 ...
Camptotheca sp.) (1, 2). In-spite of multiple drugs being available in the market, cancer is still one of leading causes of ...
Camptotheca: (Camptothecin, Topotecan, Irinotecan), Podophyllum:(Etoposide, Teniposide). CI monoclonal antibodies. Receptor ...
Camptotheca acuminata PlantCyc QUINOLINATE. Cannabis sativa PlantCyc QUINOLINATE. Capsella grandiflora PlantCyc QUINOLINATE. ...
Camptotheca acuminata PlantCyc ADENINE. Cannabis sativa PlantCyc ADENINE. Capsella grandiflora PlantCyc ADENINE. ...
Camptotheca (Camptothecin · Topotecan · Irinotecan · Rubitecan · Belotecan); 2. Podophyllum (Etoposide · Teniposide); 3a. ...
  • Blastococcus endophyticus is a bacterium from the genus of Blastococcus which has been isolated from the leaves of the plant Camptotheca acuminata from Yunnan in China. (wikipedia.org)
  • There can be many years between promising laboratory work and the availability of an effective anti-cancer drug: Monroe Eliot Wall discovered anti-cancer properties in Camptotheca in 1958, but it was not until 1996 - after further research and rounds of clinical trials - that topotecan, a synthetic derivative of a chemical in the plant, was approved for use by the US Food and Drug Administration. (wikipedia.org)