Camphor: A bicyclic monoterpene ketone found widely in plants, especially CINNAMOMUM CAMPHORA. It is used topically as a skin antipruritic and as an anti-infective agent.Camphor 5-Monooxygenase: A soluble cytochrome P-450 enzyme that catalyzes camphor monooxygenation in the presence of putidaredoxin, putidaredoxin reductase, and molecular oxygen. This enzyme, encoded by the CAMC gene also known as CYP101, has been crystallized from bacteria and the structure is well defined. Under anaerobic conditions, this enzyme reduces the polyhalogenated compounds bound at the camphor-binding site.Oxygenases: Oxidases that specifically introduce DIOXYGEN-derived oxygen atoms into a variety of organic molecules.Mixed Function Oxygenases: Widely distributed enzymes that carry out oxidation-reduction reactions in which one atom of the oxygen molecule is incorporated into the organic substrate; the other oxygen atom is reduced and combined with hydrogen ions to form water. They are also known as monooxygenases or hydroxylases. These reactions require two substrates as reductants for each of the two oxygen atoms. There are different classes of monooxygenases depending on the type of hydrogen-providing cosubstrate (COENZYMES) required in the mixed-function oxidation.Kynurenine 3-Monooxygenase: An NADPH-dependent flavin monooxygenase that plays a key role in the catabolism of TRYPTOPHAN by catalyzing the HYDROXYLATION of KYNURENINE to 3-hydroxykynurenine. It was formerly characterized as EC 1.14.1.2 and EC 1.99.1.5.Cinnamomum camphora: A tree, Cinnamomum camphora (L.) J. Presl, known as the source of CAMPHOR.Cytochrome P-450 Enzyme System: A superfamily of hundreds of closely related HEMEPROTEINS found throughout the phylogenetic spectrum, from animals, plants, fungi, to bacteria. They include numerous complex monooxygenases (MIXED FUNCTION OXYGENASES). In animals, these P-450 enzymes serve two major functions: (1) biosynthesis of steroids, fatty acids, and bile acids; (2) metabolism of endogenous and a wide variety of exogenous substrates, such as toxins and drugs (BIOTRANSFORMATION). They are classified, according to their sequence similarities rather than functions, into CYP gene families (>40% homology) and subfamilies (>59% homology). For example, enzymes from the CYP1, CYP2, and CYP3 gene families are responsible for most drug metabolism.Methylococcaceae: A family of gram-negative, aerobic bacteria utilizing only one-carbon organic compounds and isolated from in soil and water.Pseudomonas putida: A species of gram-negative, aerobic bacteria isolated from soil and water as well as clinical specimens. Occasionally it is an opportunistic pathogen.BornanesMethylococcus capsulatus: A species of METHYLOCOCCUS which forms capsules and is capable of autotrophic carbon dioxide fixation. (From Bergey's Manual of Determinative Bacteriology, 9th ed)Pseudomonas: A genus of gram-negative, aerobic, rod-shaped bacteria widely distributed in nature. Some species are pathogenic for humans, animals, and plants.Chrysanthemum: A plant genus of the family ASTERACEAE. The common names of daisy or marguerite are easily confused with other plants. Some species in this genus have been reclassified to TANACETUM.Juniperus: A plant genus of the family CUPRESSACEAE. The species are slow growing coniferous evergreen trees or shrubs.Oils, Volatile: Oils which evaporate readily. The volatile oils occur in aromatic plants, to which they give odor and other characteristics. Most volatile oils consist of a mixture of two or more TERPENES or of a mixture of an eleoptene (the more volatile constituent of a volatile oil) with a stearopten (the more solid constituent). The synonym essential oils refers to the essence of a plant, as its perfume or scent, and not to its indispensability.NorbornanesMonoterpenes: Compounds with a core of 10 carbons generally formed via the mevalonate pathway from the combination of 3,3-dimethylallyl pyrophosphate and isopentenyl pyrophosphate. They are cyclized and oxidized in a variety of ways. Due to the low molecular weight many of them exist in the form of essential oils (OILS, VOLATILE).Hydroxylation: Placing of a hydroxyl group on a compound in a position where one did not exist before. (Stedman, 26th ed)ButanesOxidation-Reduction: A chemical reaction in which an electron is transferred from one molecule to another. The electron-donating molecule is the reducing agent or reductant; the electron-accepting molecule is the oxidizing agent or oxidant. Reducing and oxidizing agents function as conjugate reductant-oxidant pairs or redox pairs (Lehninger, Principles of Biochemistry, 1982, p471).Methylosinus trichosporium: A species of METHYLOSINUS which is capable of degrading trichloroethylene and other organic pollutants.Antifoaming Agents: Agents used to prevent the formation of foam or to treat flatulence or bloat.Nitrosomonas: A genus of gram-negative, ellipsoidal or rod-shaped bacteria whose major source of energy and reducing power is from the oxidation of ammonia to nitrite. Its species occur in soils, oceans, lakes, rivers, and sewage disposal systems.Flavin-Adenine Dinucleotide: A condensation product of riboflavin and adenosine diphosphate. The coenzyme of various aerobic dehydrogenases, e.g., D-amino acid oxidase and L-amino acid oxidase. (Lehninger, Principles of Biochemistry, 1982, p972)Epilepsy, Tonic-Clonic: A generalized seizure disorder characterized by recurrent major motor seizures. The initial brief tonic phase is marked by trunk flexion followed by diffuse extension of the trunk and extremities. The clonic phase features rhythmic flexor contractions of the trunk and limbs, pupillary dilation, elevations of blood pressure and pulse, urinary incontinence, and tongue biting. This is followed by a profound state of depressed consciousness (post-ictal state) which gradually improves over minutes to hours. The disorder may be cryptogenic, familial, or symptomatic (caused by an identified disease process). (From Adams et al., Principles of Neurology, 6th ed, p329)Alkanes: The generic name for the group of aliphatic hydrocarbons Cn-H2n+2. They are denoted by the suffix -ane. (Grant & Hackh's Chemical Dictionary, 5th ed)Perfume: A substance, extract, or preparation for diffusing or imparting an agreeable or attractive smell, especially a fluid containing fragrant natural oils extracted from flowers, woods, etc., or similar synthetic oils. (Random House Unabridged Dictionary, 2d ed)Ferredoxins: Iron-containing proteins that transfer electrons, usually at a low potential, to flavoproteins; the iron is not present as in heme. (McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)Alkane 1-Monooxygenase: A P450 oxidoreductase that catalyzes the hydroxylation of the terminal carbon of linear hydrocarbons such as octane and FATTY ACIDS in the omega position. The enzyme may also play a role in the oxidation of a variety of structurally unrelated compounds such as XENOBIOTICS, and STEROIDS.Substrate Specificity: A characteristic feature of enzyme activity in relation to the kind of substrate on which the enzyme or catalytic molecule reacts.3-Hydroxyanthranilate 3,4-Dioxygenase: An enzyme that catalyzes the conversion of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde. It was formerly characterized as EC 1.13.1.6.3-Hydroxyanthranilic Acid: An oxidation product of tryptophan metabolism. It may be a free radical scavenger and a carcinogen.Pseudomonas fluorescens: A species of nonpathogenic fluorescent bacteria found in feces, sewage, soil, and water, and which liquefy gelatin.Green Chemistry Technology: Pollution prevention through the design of effective chemical products that have low or no toxicity and use of chemical processes that reduce or eliminate the use and generation of hazardous substances.Nitrobenzoates: Benzoic acid or benzoic acid esters substituted with one or more nitro groups.Phloroglucinol: A trinitrobenzene derivative with antispasmodic properties that is used primarily as a laboratory reagent.Phenylacetates: Derivatives of phenylacetic acid. Included under this heading are a variety of acid forms, salts, esters, and amides that contain the benzeneacetic acid structure. Note that this class of compounds should not be confused with derivatives of phenyl acetate, which contain the PHENOL ester of ACETIC ACID.Research: Critical and exhaustive investigation or experimentation, having for its aim the discovery of new facts and their correct interpretation, the revision of accepted conclusions, theories, or laws in the light of newly discovered facts, or the practical application of such new or revised conclusions, theories, or laws. (Webster, 3d ed)Sarcosine Oxidase: A FLAVOPROTEIN, this enzyme catalyzes the oxidation of SARCOSINE to GLYCINE; FORMALDEHYDE; and HYDROGEN PEROXIDE (H2O2).Research Personnel: Those individuals engaged in research.Research Support as Topic: Financial support of research activities.Oxygen: An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.Biomedical Research: Research that involves the application of the natural sciences, especially biology and physiology, to medicine.Piloerection: Involuntary erection or bristling of hairs.Stereoisomerism: The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)Alexander Disease: Rare leukoencephalopathy with infantile-onset accumulation of Rosenthal fibers in the subpial, periventricular, and subependymal zones of the brain. Rosenthal fibers are GLIAL FIBRILLARY ACIDIC PROTEIN aggregates found in ASTROCYTES. Juvenile- and adult-onset types show progressive atrophy of the lower brainstem instead. De novo mutations in the GFAP gene are associated with the disease with propensity for paternal inheritance.Ocular Physiological Processes: Biological action and events that support the functions of the EYE and VISION, OCULAR.Weight Gain: Increase in BODY WEIGHT over existing weight.Methanosarcina barkeri: A species of halophilic archaea whose organisms are nonmotile. Habitats include freshwater and marine mud, animal-waste lagoons, and the rumens of ungulates.Search Engine: Software used to locate data or information stored in machine-readable form locally or at a distance such as an INTERNET site.Urease: An enzyme that catalyzes the conversion of urea and water to carbon dioxide and ammonia. EC 3.5.1.5.Information Storage and Retrieval: Organized activities related to the storage, location, search, and retrieval of information.Semiconductors: Materials that have a limited and usually variable electrical conductivity. They are particularly useful for the production of solid-state electronic devices.Aspergillus oryzae: An imperfect fungus present on most agricultural seeds and often responsible for the spoilage of seeds in bulk storage. It is also used in the production of fermented food or drink, especially in Japan.Internet: A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.

Putidaredoxin-cytochrome p450cam interaction. Spin state of the heme iron modulates putidaredoxin structure. (1/143)

During the monooxygenase reaction catalyzed by cytochrome P450cam (P450cam), a ternary complex of P450cam, reduced putidaredoxin, and d-camphor is formed as an obligatory reaction intermediate. When ligands such as CO, NO, and O2 bind to the heme iron of P450cam in the intermediate complex, the EPR spectrum of reduced putidaredoxin with a characteristic signal at 346 millitesla at 77 K changed into a spectrum having a new signal at 348 millitesla. The experiment with O2 was carried out by employing a mutant P450cam with Asp251 --> Asn or Gly where the rate of electron transfer from putidaredoxin to oxyferrous P450cam is considerably reduced. Such a ligand-induced EPR spectral change of putidaredoxin was also shown in situ in Pseudomonas putida. Mutations introduced into the neighborhood of the iron-sulfur cluster of putidaredoxin revealed that a Ser44 --> Gly mutation mimicked the ligand-induced spectral change of putidaredoxin. Arg109 and Arg112, which are in the putative putidaredoxin binding site of P450cam, were essential for the spectral changes of putidaredoxin in the complex. These results indicate that a change in the P450cam active site that is the consequence of an altered spin state is transmitted to putidaredoxin within the ternary complex and produces a conformational change of the 2Fe-2S active center.  (+info)

Surface-modified mutants of cytochrome P450cam: enzymatic properties and electrochemistry. (2/143)

We report the electrochemistry of genetic variants of the haem monooxygenase cytochrome P450cam. A surface cysteine-free mutant (abbreviated as SCF) was prepared in which the five surface cysteine residues Cys-58, Cys-85, Cys-136, Cys-148 and Cys-334 were changed to alanines. Four single surface cysteine mutants with an additional mutation, R72C, R112C, K344C or R364C, were also prepared. The haem spin-state equilibria, NADH turnover rates and camphor-hydroxylation properties, as well as the electrochemistry of these mutants are reported. The coupling of a redox-active label, N-ferrocenylmaleimide, to the single surface cysteine mutant SCF-K344C, and the electrochemistry of this modified mutant are also described.  (+info)

The thermodynamics and kinetics of electron transfer in the cytochrome P450cam enzyme system. (3/143)

In anaerobic environments the first electron transfer in substrate-free P450cam is known to be thermodynamically unfavourable, but in the presence of dioxygen the reduction potential for the reaction shifts positively to make electron transfer thermodynamically favourable. Nevertheless a slower rate of electron transfer is observed in the substrate-free P450cam compared to substrate-bound P450cam. The ferric haem centre in substrate-free P450cam changes from six co-ordinate to five co-ordinate when reduced whereas in substrate-bound P450cam the iron centre remains five co-ordinate in both oxidation states. The slower rate of electron transfer in the substrate-free P450cam is therefore attributed to a larger reorganisation energy as predicted by Marcus theory.  (+info)

Proton nuclear magnetic resonance study of the binary complex of cytochrome P450cam and putidaredoxin: interaction and electron transfer rate analysis. (4/143)

A 1H nuclear magnetic resonance study of the complex of cytochrome P450cam-putidaredoxin has been performed. Isocyanide is bound to cytochrome P450cam in order to increase the stability of the protein both in the reduced and the oxidized state. Diprotein complex formation was detected through variation of the heme methyl proton resonances which have been assigned in the two redox states. The electron transfer rate at equilibrium was determinated by magnetization transfer experiments. The observed rate of oxidation of reduced cytochrome P450 by the oxidized putidaredoxin is 27 (+/- 7) per s.  (+info)

A high-throughput digital imaging screen for the discovery and directed evolution of oxygenases. (5/143)

BACKGROUND: Oxygenases catalyze the hydroxylation of a wide variety of organic substrates. An ability to alter oxygenase substrate specificities and improve their activities and stabilities using recombinant DNA techniques would expand their use in processes such as chemical synthesis and bioremediation. Discovery and directed evolution of oxygenases require efficient screens that are sensitive to the activities of interest and can be applied to large numbers of crude enzyme samples. RESULTS: Horseradish peroxidase (HRP) couples the phenolic products of hydroxylation of aromatic substrates to generate colored and/or fluorescent compounds that are easily detected spectroscopically in high-throughput screening. Coexpression of the coupling enzyme with a functional mono- or dioxygenase creates a pathway for the conversion of aromatic substrates into fluorescent compounds in vivo. We used this approach for detecting the products of the toluene-dioxygenase-catalyzed hydroxylation of chlorobenzene and to screen large mutant libraries of Pseudomonas putida cytochrome P450cam by fluorescence digital imaging. Colors generated by the HRP coupling reaction are sensitive to the site of oxygenase-catalyzed hydroxylation, allowing the screen to be used to identify catalysts with new or altered regiospecificities. CONCLUSIONS: The coupled oxygenase-peroxidase reaction system is well suited for screening oxygenase libraries to identify mutants with desired features, including higher activity or stability and altered reaction specificity. This approach should also be useful for screening expressed DNA libraries and combinatorial chemical libraries for hydroxylation catalysts and for optimizing oxygenase reaction conditions.  (+info)

Mutations of glutamate-84 at the putative potassium-binding site affect camphor binding and oxidation by cytochrome p450cam. (6/143)

Cytochrome P450cam (CYP101) from Pseudomonas putida is unusual among P450 enzymes in that it exhibits co-operative binding between the substrate camphor and a potassium ion. This behaviour has been investigated by mutagenesis of Glu84, a surface residue which forms part of the cation-binding site. Substitutions that neutralize or reverse the charge of this side chain are shown to disrupt the co-operativity of potassium and camphor binding by P450cam, and also to influence the catalytic activity. In particular, replacement of Glu84 by positively charged residues such as lysine results in increased high-spin haem fractions and camphor turnover activities in the absence of potassium, along with decreased camphor dissociation constants. However, in the presence of potassium the camphor dissociation constants of these mutants are significantly increased compared with the wild-type, although the camphor turnover activities remain marginally higher. In contrast, substitution by aspartate results in tighter binding of both potassium and camphor, but has little effect on the enzymatic activity. In all cases the reaction remains essentially 100% coupled and gives 5-exo-hydroxycamphor as the only product. These results suggest that an anionic side chain at the 84 position is crucial for the co-operativity of camphor and cation binding, and that the physiological role for potassium binding by cytochrome P450cam is to promote camphor binding even at the expense of turnover rate, thus allowing the organism to utilize low environmental concentrations of this substrate for growth.  (+info)

Optical detection of cytochrome P450 by sensitizer-linked substrates. (7/143)

The ability to detect, characterize, and manipulate specific biomolecules in complex media is critical for understanding metabolic processes. Particularly important targets are oxygenases (cytochromes P450) involved in drug metabolism and many disease states, including liver and kidney dysfunction, neurological disorders, and cancer. We have found that Ru photosensitizers linked to P450 substrates specifically recognize submicromolar cytochrome P450(cam) in the presence of other heme proteins. In the P450:Ru-substrate conjugates, energy transfer to the heme dramatically accelerates the Ru-luminescence decay. The crystal structure of a P450(cam):Ru-adamantyl complex reveals access to the active center via a channel whose depth (Ru-Fe distance is 21 A) is virtually the same as that extracted from an analysis of the energy-transfer kinetics. Suitably constructed libraries of sensitizer-linked substrates could be employed to probe the steric and electronic properties of buried active sites.  (+info)

Assignment of heme methyl 1H-NMR resonances of high-spin and low-spin ferric complexes of cytochrome p450cam using one-dimensional and two-dimensional paramagnetic signals enhancement (PASE) magnetization transfer experiments. (8/143)

An 1H-NMR study of ferric cytochrome P450cam in different paramagnetic states was performed. Assignment of three heme methyl resonances of the isocyanide adduct of cytochrome P450 in the ferric low-spin state was recently performed using electron exchange in the presence of putidaredoxin [Mouro, C., Bondon, A., Jung, C., Hui Bon Hoa, G., De Certaines, J.D., Spencer, R.G.S. & Simonneaux, G. (1999) FEBS Lett. 455, 302-306]. In this study, heme methyl protons of cytochrome P450 in the native high-spin and low-spin states were assigned through one-dimensional and two-dimensional magnetization transfer spectroscopy using the paramagnetic signals enhancement (PASE) method. The order of the methyl proton chemical shifts is inverted between high-spin and low-spin states. The methyl order observed in the ferric low-spin isocyanide complexes is related to the orientation of the cysteinate ligand.  (+info)

Ramamurthy, AC and Sathyanarayana, S (1976) Novel aspects of adsorption of d-camphor 10-sulphonate ion at a mercury/solution interface. In: Journal of Electroanalytical Chemistry, 73 (2). pp. 253-259. ...
1Q1W: Crystal structure of putidaredoxin reductase from Pseudomonas putida, the final structural component of the cytochrome P450cam monooxygenase.
1Q1W: Crystal structure of putidaredoxin reductase from Pseudomonas putida, the final structural component of the cytochrome P450cam monooxygenase.
Current treatments for trypanosome diseases like sleeping sickness often lack specificity and have severe side effects. Thus, newer, better drug targets are needed. Trypanosomal sterol 14α-demethylase (14DM), an essential enzyme in the production of membrane sterols, is a highly promising lead, as its fungal counterpart is a major drug target for treating fungal infections in humans. In this study, the authors solved 1.9 Å resolution crystal structures of 14DM from Trypanosoma brucei in both a native state and in a complex with the inhibitor VN1. Together, they provide the first structural insights into a eukaryotic microsomal 14DM. The structures show that the organization of the active site cavity and the location of the substrate access channel differ profoundly in 14DM compared with water-soluble members of the CYP51 family. VN1 binding does not cause large-scale conformational rearrangements, but it does induce local changes in the active site, including the formation of a hydrogen bond ...
The transparent alloy furnace is running a first batch of mixtures succinonitrile, D-camphor and neopentyl glycol, contained inside a glass-wall cartridge at an agonisingly slow pace: they take upwards of two days to travel 1 mm, but the experiment runs on its own for several weeks. The g…
Plasmid pOSIP-CH (CamR, HK022) from Dr. Drew Endys lab is published in ACS Synth Biol. 2013 Sep 20;2(9):537-41. doi: 10.1021/sb400021j. Epub 2013 May 20. This plasmid is available through Addgene.
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Using CAMPHOR SPIRITS LIQ 10% during pregnancy may raise the risk of children developing some disorder (commpon for some such kind of drugs), however it depends upon how CAMPHOR SPIRITS LIQ 10% ingredients pass through placenta and may have effect on baby - Strength of CAMPHOR SPIRITS LIQ 10% is major factor in determination of such side effects, The possible danger in pregnancy are under research. CHIESI ESPAÑA, S.A. Canada publish leaflet about CAMPHOR SPIRITS LIQ 10% every update to describe possible risks of using CAMPHOR SPIRITS LIQ 10% side effect in pregnancy and pregnant women. You may download CHIESI ESPAÑA, S.A. issued leaflet regarding side effects of CAMPHOR SPIRITS LIQ 10% - CAMPHOR. Pregnancy Side Effects can be easily know by Atc code of CAMPHOR SPIRITS LIQ 10% ATC CODE.. ...
Define Camphor weed. Camphor weed synonyms, Camphor weed pronunciation, Camphor weed translation, English dictionary definition of Camphor weed. The foliage of this plant smells strongly of camphor and was sometimes used instead of camphor. The plant belongs to the sunflower family . Note: A 1918...
China Dl-Camphor; Camphor Synthetic; 2-Bornanone; 2-Camphanone; CAS No76-22-2, Camphor, Find details about China Synthetic Camphor, DAB6 from Dl-Camphor; Camphor Synthetic; 2-Bornanone; 2-Camphanone; CAS No76-22-2, Camphor - ANHUI HOPE-CHEM CO., LTD.
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Camphor Lamp: Starstell provides you high quality Brass made Camphor Lamp with free camphor at very affordable and competitive price with warranty.
From the size of its trunk, it is old, but what makes it special is perhaps not its age, which obviously helps, but its struggle to thrive in such a confined environment - it is truly a product of our city. Restricted by the narrow path, it has had no choice by to grow straight up, which is not characteristics of camphors, which typically have multiple limbs spreading out into an expansive canopy, like those just around the corner from this tree in West End Park.. Thats not to say, the camphors is lacking in splendour. Its trunk has acquired a distinct shape, showing the years when it has had to build up mass and energy for its reach for the precious sunlight seeping down from between the buildings.. ...
Genzyme sells drug products each containing camphor in crosslinking the united states under surface the trademark prescription drug (freely sold in tears some regions). It would be difficult to allege that how someone requesting Cheezheng pain relieving capacity is acquiring camphor for abuse. Mucinex childrens cold, cough & sore throat throat contains Phenylephrine which should decide not be taken with mao inh
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Review: To me the quality of the products is excellent, The Camphor included. I take quality for granted dealing with Zooscape. However the amazing
|P| Camphor oil is one of the most commonly used oils in medicine. Additionally, it is also considered an effective household remedy for many ailments. It has strong a...
Camphor Confidences Shattered lyrics & video : You cleaned us out while we were blind Stole our car and drank our wine Fumbled around inside our drawers Crept in and kept us up...
1824 Camphor Way is a real estate Single Family property that is for sale by Berkshire Hathaway HomeServices Drysdale Properties on www.bhhsdrysdale.com. The MLS# is 17077276 and it is available for $337,000. Includes 3 Beds , 2 Baths and 1201 square feet.
All that was years ago. In recent years, Camphor has apparently been anchored to a massive, heavy, cast iron and bronze hanging oil lamp in the parents bedroom. Occasionally, the lamp starts swinging when there is no explanation. A number of us have seen the swinging, have verified that nothing else in the room is moving even the slightest bit, not even the delicate flowers on the bureau next to it ...
Camphorated Oil information about active ingredients, pharmaceutical forms and doses by DC Labs, Camphorated Oil indications, usages and related health products lists
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He who hath attained this station is sanctified from all that pertaineth to the world. Wherefore, if those who have come to the sea of His presence are found to possess none of the limited things of this perishable world, whether it be outer wealth or personal opinions, it mattereth not. For whatever the creatures have is limited by their own limits, and whatever the True One hath is sanctified therefrom; this utterance must be deeply pondered that its purport may be clear. "Verily the righteous shall drink of a winecup tempered at the camphor fountain." [2] If the interpretation of "camphor" become known, the true intention will be evident. This state is that poverty of which it is said, "Poverty is My glory." [3] And of inward and outward poverty there is many a stage and many a meaning which I have not thought pertinent to mention here; hence I have reserved these for another time, dependent on what God may desire and fate may seal ...
Herbalists use camphor to treat the patients of hyper metabolism. Camphor is a good stimulator. By stimulating the circulation of blood, it helps in improving
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Ecologically Harvested is a term that describes all herbs sold by Gaia Herbs that are not Certified Organic. Ecologically Harvested herbs include herbs that are harvested in their natural habitat, (i.e., wild harvested) according to specific guidelines for harvesting these herbs (i.e., away from roads and industry, as well as guidelines to avoid overharvesting). Our term, Ecologically Harvested, also includes herbs that are grown in managed woodland areas, fields designated for specific herbs, and herbs that are grown by indigenous growers, such as Kava Kava. All Ecologically Harvested herbs pass pesticide and heavy metal testing as well as microbial testing, prior to release ...
Camphor music - free on Blip.fm. Listen to Camphor mp3s, watch Camphor videos, find Camphor fans. Search for free music to stream.
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Camphor definition, a whitish, translucent, crystalline, pleasant-odored terpene ketone, C 10 H 16 O, obtained from the camphor tree, used chiefly in the manufacture of celluloid and in medicine as a counter-irritant for infections and in the treatment of pain and itching. See more.
Post a Comment for 1:30 A.M. Peter, 15 years old (on left). Employed in camphor works. Air full of camphor. Sells papers Saturday nights until 3 A.M. One of a dozen boys who sleep in car barn these nights. Charles, 11 years old (on right). Gets supper in restaurant. Sells every day. Brother of #3117. Location: Jersey City, New Jersey. ...
Camphor is a mild topical (for the skin) pain reliever. Menthol is either manmade or made from the extracts of mint oil. Menthol provides a cooling sensation when applied to the skin. Camphor and menthol is a combination medicine used to relieve minor muscle or joint pain. Camphor and menthol topical may also be used...
Cytochrome P450 enzymes (P450s) have been implicated in insecticide resistance. Anopheles minumus mosquito P450 isoforms CYP6AA3 and CYP6P7 are capable of metabolizing pyrethroid insecticides, however CYP6P8 lacks activity against this class of compounds. Homology models of the three An. minimus P450 enzymes were constructed using the multiple template alignment method. The predicted enzyme model structures were compared and used for molecular docking with insecticides and compared with results of in vitro enzymatic assays. The three model structures comprise common P450 folds but differences in geometry of their active-site cavities and substrate access channels are prominent. The CYP6AA3 model has a large active site allowing it to accommodate multiple conformations of pyrethroids. The predicted CYP6P7 active site is more constrained and less accessible to binding of pyrethroids. Moreover the predicted hydrophobic interface in the active-site cavities of CYP6AA3 and CYP6P7 may contribute to their
Nominated Substances: Camphor, D-Camphor. Nomination Date: 11/08/1985 Nominator: NCI Rationale: Significant human exposure for its use in over-the-counter preparations, as a plasticizer for cellulose esters and ethers, in varnishes, moth repellents, and as a preservative in cosmetics & pharmaceuticals; insufficient data for the evaluation of potential carcinogenicity NTP Principles: Pre 1993 - 8 Status: Selected ...
Camphor occurs in nature in its dextrorotatory form (D-camphor), while the laevorotatory form (Lcamphor) exists only as a synthetic form. The two enantiomers present different profiles of toxicity. D-camphor, L-camphor and their racemic mixture were tested for toxicity in mice. At 100 mg · Kg b.w.-1 the natural form was non toxic, while the synthetic form induced different kinds of toxic and behavioural effects such as body jerks and hunched posture; the racemic mixture showed similar effects to the L-form (Chatterjie and Alexander, 1986). The oral administration of acute doses of Dcamphor to rats and rabbits caused pronounced signs of toxicity. In rats, the consume of food was reduced proportionally to the administered dose, starting from 464 mg · Kg b.w.-1 · day-1, and at 1000 mg · Kg b.w.-1 · day-1 convulsions and piloerection were observed, connected with a reduction of motility and weight gain. Reduced body weight gain and food consumption were observed in rabbits treated with 681 mg ...
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Guerlains Stop Spot has a high concentration of purifying Camphor. It also includes salicylic acid and zinc oxide so it is very difficult to ascertain whether camphor alone is a star acne ingredient here. Also, Mario Badescu and Malin Goetz are great products but the star congestion clear buy for me is the Eve Lom Rescue Mask!⠀⠀. For me, Stop Spot is soothing, non-drying, counteracts redness, has a slight camouflaging effect, and works best when left overnight. I personally feel it works best as a preventative treatment and for camouflaging redness during the day. It is not strong enough to deal with one of my angry red pustules which crop up.. ...
Compounded with pure camphor, De La Cruz® Camphor Ointment is for temporary relief from the discomforts of arthritis, rheumatism, muscle aches, backaches and sprains.
Find Condo for sale in in Camphor Avenue Singapore property listings, Condo property from 3 Bedrooms to 6 Bedrooms for sale in Singapore Property Listings.Browse Condo for sale in Singapore at STProperty with 10 Results Per Page.
... , China supplier of Aromatic Chemicals, Essential Oils, Food Additive, Food Ingredients, Forest Chemicals, Natural Aromatic Chemicals, and more.
Earlier this year, the FDA approved Anthelios SX, an over-the-counter product that contains a camphor derivative (ecamsule/Mexoryl SX), which is photostable and targets UVA radiation. In addition, Neutrogena has added a stabilizer, Helioplex, to several of its products containing avobenzone and other UVA blockers, which might boost their efficacy in protecting against a spectrum of UVA wavelengths.. The questions are, "How good are they? Which is better?" asks Dr. DeLeo from St. Lukes-Roosevelt and Beth Israel Medical Centers in New York City.. (more…). ...
Camphor, machinist tool rust preventative, keeps possums off your roof and helps silver stay shiny longer http://www.sell.com/2C92J
The therapeutic properties of Camphor Essential Oil include the following: anti-inflammatory, antiseptic, cardiac, carminative, diuretic, febrifuge, insecticide, laxative, stimulant and vulnerary.
A unique Vintage Celluloid Pin with original Paint. This pin has original simple hook clasp. Test is positive using hot water. Measures about 2 3/4" by 3/4" at widest points. ...
Anthelios L Ecran Intolerances Solaires SPF 60 information about active ingredients, pharmaceutical forms and doses by La Roche-Posay, Anthelios L Ecran Intolerances Solaires SPF 60 indications, usages and related health products lists
camphor-oil: A yellowish-brown liquid which drains from the crude camphor of commerce, having a camphor-like odor and taste, and containing a considerable quantity of camphor in solution.
MLS listing number 150065885. Were sorry, the InstaView Virtual Tour you are trying to view has been made inactive for the listing at 6914 Camphor Lane, San Diego, CA 92139 | 150065885
The work to be presented herein illustrates several important facts. First, the synthesis of BIBOL (19), a 1,4-diol derived from the monoterpene camphor has allowed us to demonstrate that oxidative dimerizations of ...
First of all, I never meant to insult Freud. I love Freud and, like Harold Bloom, consider him one of the great artists of the 20th century. Nevertheless, I dont entirely agree with Mixing Memory. For one thing, Freud didnt invent the unconscious. He sexualized it, and made it synonymous with eros, Oedipus, and sin. Personally, I consider Samuel Taylor Coleridges version of the unconscious to be much closer to the current views of neuroscience. Coleridge was an opium addict, and even though the "sweet poison" destroyed his life, it did, he said, "reveal to me the minds self-experience in the act of thinking." Strung out on purple smoke, "in a profound sleep, at least of the external senses," Coleridge would compose line after surreal line, none of which he was able to consciously understand. He discovered that his own mind was as "deep as the sea," guarded by a "deep romantic chasm." What Coleridge called the imagination we now call unconscious processing: "It [the imagination] dissolves, ...
Benefits Of Using Camphor Essential For Hair Growth. Different variation of camphor essential oil is derived from the roots and woods of the camphor tree by three processes as mentioned below:. 1.White Camphor Oil: The white camphor oil is produced by the steam distillation of the basis, stumps, branches, and wood of the tree. It is non-toxic and the most widely used variation of camphor oil.. 2.Brown Camphor Oil: The second means of extraction produces brown camphor oil, which involves rectification of the root, stumps, and wood of the tree under vacuum. The brown camphor oil contains safrole which is toxic and can cause cancer.. 3.Yellow Camphor Oil: The third variation of camphor oil, the yellow camphor oil is produced by the strategy of filter pressing. Similar to the brown camphor oil, the yellow camphor oil can also be toxic and is not utilized in aromatherapy.. Out of the three types of camphor oil, the white camphor oil is used in several medicinal and aromatherapy purposes on account of ...
Images of Camphor Basil or Ocimum kilimanscharicum at google.com Ocimum kilimanscharicum is also known as Camphor basil is an herb.. Overview of Camphor Basil • It is used to treat intestinal upsets. • It is a large plant with grey-green foliage. • It is a strong medicinal herb with camphor scent. • It spreads […]. ...
The Food and Drug Administration (FDA) includes Camphor in its list of flavoring agents and related substances that are permitted for direct addition to food. Camphor is also approved for use as an active ingredient in Over-The-Counter (OTC) external analgesics, topical antitussive drug products and in anorectal products at concentrations of 0.1 to 3%. The Cosmetic Ingredient ...
TY - JOUR. T1 - Resonance surface plasmon spectroscopy. T2 - Low molecular weight substrate binding to cytochrome P450. AU - Zhao, Jing. AU - Das, Aditi. AU - Zhang, Xiaoyu. AU - Schatz, George C. AU - Sligar, Stephen G.. AU - Van Duyne, Richard P.. PY - 2006/8/30. Y1 - 2006/8/30. N2 - A new detection mechanism has been developed for low molecular weight substrate binding to heme proteins based on resonance localized surface plasmon spectroscopy. Cytochrome P450 has strong electronic transitions in the visible wavelength region. Upon binding of a substrate molecule (e.g., camphor), the absorption band of cytochrome P450 shifts to shorter wavelength. The event of camphor binding to a nanoparticle surface modified with cytochrome P450 protein receptors is monitored using UV-vis spectroscopy. It is observed for the first time that the binding of the substrate molecules to the protein receptor induces a blue-shift in the localized surface plasmon resonance (LSPR) of the nanosensors. The coupling ...
1. Perfusion of the normal frogs heart with camphor failed to produce any constant effect which can be considered with certainty an evidence of stimulation.. 2. Application of a saturated solution of camphor to the exterior of a chloralized frogs heart caused marked but rather transient increase in rate of contraction. Ether solution applied in the same way had a similar though less marked effect.. 3. The rate of contractions in isolated strips of normal ventricular muscle from the turtles heart, was increased by moderate amounts of camphor in a majority of experiments. The amplitude of the contractions was not increased. Camphor was without effect in chloralized strips.. 4. In the normal isolated dogs heart camphor failed to produce any distinct and constant stimulation; such effects as were observed were too slight and occurred too seldom to be attributed with certainty to stimulation by the drug. In chioralized dogs hearts and in hearts that showed fatty degeneration from poisonous doses ...
Animesh Dhar is Executive Director:Ops at Camphor & Allied Products Ltd. See Animesh Dhars compensation, career history, education, & memberships.
Can be used as a disincrustation cleanser for oily and problem skin types prior to extractions to soften and dissolve oils and pollutants congesting the skin (apply to face with water, lather then steam 2-5 minutes. Proceed with extraction). For sensitive skin do not steam. Could be followed by Camphor Astringent for disinfection. Then Enzyme Peeling Cream for exfoliation and Bio Drying or Blemish Control Mask for soothing. A second mask can be used for moisturizing (Cucumber Ice Sorbet or Azulen Mask). Can be used as lipid layer neutralizer prior to AHA or Enzyme in-salon treatment ...
Y. Soeta and Y. Ando, "Analysis of the temporal features and subjective preferences related images of camphor leaves moving in the wind," in Vision Science and its Applications, OSA Technical Digest (Optical Society of America, 2000), paper FF1 ...
Rated 5 out of 5 by Sistersthatshop This has really helped my Mum My Mum suffers with osteo and rheumatoid arthritis and has painful hips, knees and ankles. She is now able to sleep better after using this product. It feels soothing once applied and has also taken the swelling down. She swears by it. Please can you do a supersize or if not a duo? Have also given it to my Husband and cousin who have both used it successfully on their knees Absolutely brilliant product. June 15, 2015 ...
The author retains all rights to this work. The author has signed an agreement granting HKBU a non-exclusive license to archive and distribute their thesis.. ...
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Its uses include: temporary relief of minor aches and pains of muscles and joints and a cough suppressant. Trusted since 1868. ...
your thirst with disastrous unhealthy benefits.Always love the taste of jaggery for its rounded earthiness more than sugar.I thoroughly enjoy each and every sip!it gives total coolness to our body and gut.Sometimes even pepper powder is also added for extra punch and some where I saw that they add even edible camphor.But personally I dont like adding edible camphor to it!but altogether its a perfect summer drink.If you serve it to someone who are not introduced to this drink will feel this drink more treasurable than anything.You can make this drink in advance and keep it in fridge for two days also!it becomes even more flavourful the next day.. ...
Long-lasting hydration fix for lips, enriched with Shea Butter, Camphor and Allantoin to condition, perfect and protect deep down.
Free flashcards to help memorize facts about Abbreviations 3rd grading period:Brittany Benning. Other activities to help include hangman, crossword, word scramble, games, matching, quizes, and tests.
Find the Moose Rear Wheel Bearing Kit - 0215-1007 at Dennis Kirk. Shop our complete selection of parts and accessories including the Moose Rear Wheel Bearing Kit - 0215-1007.
... camphor 5-monooxygenase MeSH D12.776.422.220.453.915 - steroid hydroxylases MeSH D12.776.422.220.453.915.050 - aldosterone ... tyrosine 3-monooxygenase MeSH D12.776.575.750.500.100 - adenine nucleotide translocator 1 MeSH D12.776.575.750.500.200 - ... cyclin-dependent kinase 5 MeSH D12.776.167.200.067.900 - cyclin-dependent kinase 9 MeSH D12.776.167.200.580.500 - cdc2 protein ... myogenic regulatory factor 5 MeSH D12.776.210.500.570.600 - myogenin MeSH D12.776.210.500.600.100 - myosin heavy chains MeSH ...
4-hydroxybenzoate 3-monooxygenase MeSH D08.811.682.690.708.557 --- kynurenine 3-monooxygenase MeSH D08.811.682.690.708.601 --- ... camphor 5-monooxygenase MeSH D08.244.453.915 --- steroid hydroxylases MeSH D08.244.453.915.050 --- aldosterone synthase MeSH ... trans-cinnamate 4-monooxygenase MeSH D08.622.509.700 --- pepsinogen a MeSH D08.622.509.725 --- pepsinogen c MeSH D08.622. ... monophenol monooxygenase MeSH D08.811.682.690.708.170 --- cytochrome p-450 enzyme system MeSH D08.811.682.690.708.170.040 --- ...
Ougham, H.J.; Taylor, D.G.; Trudgill, P.W. (1983). "Camphor revisited: involvement of a unique monooxygenase in metabolism of 2 ... 2,2,3-trimethyl-5-oxocyclopent-3-enyl)acetyl-CoA synthase at the US National Library of Medicine Medical Subject Headings (MeSH ... 2,2,3-trimethyl-5-oxocyclopent-3-enyl)acetyl-CoA synthase (EC 6.2.1.38, 2-oxo-Delta3-4,5,5-trimethylcyclopentenylacetyl-CoA ... Δ3-4,5,5-trimethylcyclopentenylacetic acid by Pseudomonas putida". J. Bacteriol. 153 (1): 140-152. PMC 217351 . PMID 6848481. ( ...
... camphor hydroxylase, d-camphor monooxygenase, methylene hydroxylase, methylene monooxygenase, D-camphor-exo-hydroxylase, and ... In enzymology, a camphor 5-monooxygenase (EC 1.14.15.1) is an enzyme that catalyzes the chemical reaction (+)-camphor + ... An induced methylene hydroxylase in camphor oxidation". J. Biol. Chem. 240 (10): 4038-43. PMID 4378858. Tyson CA, Lipscomb JD, ... The systematic name of this enzyme class is (+)-camphor,reduced putidaredoxin:oxygen oxidoreductase (5-hydroxylating). Other ...
In enzymology, a camphor 1,2-monooxygenase (EC 1.14.15.2) is an enzyme that catalyzes the chemical reaction (+)-bornane-2,5- ... camphor ketolactonase I, oxygenase, camphor 1,2-mono, and ketolactonase I. It employs one cofactor, iron. CONRAD HE, DUBUS R, ... Camphor ketolactonase I and the role of three protein components". J. Biol. Chem. 244 (22): 6149-52. PMID 4310834. Molecular ... Purification of a tightly coupled electron transport complex in camphor lactonization". J. Biol. Chem. 241 (18): 4288-90. PMID ...
... camphor 1,2-monooxygenase, camphor ketolactonase I) is an enzyme with systematic name (+)-bornane-2,5-dione,NADH:oxygen ... 2-monooxygenase from the camphor metabolizing Pseudomonas putida strain NCIMB 10007". AMB Express. 1 (1): #13-13. doi:10.1186/ ... monooxygenases from camphor-grown Pseudomonas putida ATCC 17453". J. Gen. Microbiol. 139 (4): 797-805. doi:10.1099/00221287-139 ... Camphor ketolactonase I and the role of three protein components". J. Biol. Chem. 244 (22): 6149-6152. PMID 4310834. Taylor, D. ...
"Functional Assembly of camphor converting two-component Baeyer-Villiger monooxygenases with a flavin reductase from E. coli". ... 5: 25. doi:10.3389/fmicb.2014.00025. PMC 3915288 . PMID 24567729. Kadow M, Balke K, Willetts A, Bornscheuer UT, Bäckvall JE (5 ... 5 (3): 985-97. doi:10.3390/cancers5030985. PMC 3795375 . PMID 24202330. Paine MJ, Garner AP, Powell D, Sibbald J, Sales M, ...
EC 1.14.15.2 camphor 1,2-monooxygenase [(+)-camphor,reduced-rubredoxin:oxygen oxidoreductase (1,2-lactonizing)] (+)-bornane-2,5 ... H2O EC 1.14.15.3 alkane 1-monooxygenase (alkane,reduced-rubredoxin:oxygen 1-oxidoreductase) octane + reduced rubredoxin + O2 = ... ISBN 0-935702-72-5 J.J.R. Fraústo da Silva and R.J.P. Williams, The biological chemistry of the elements: The inorganic ... reduced rubredoxin + O2 = 5-oxo-1,2-campholide + oxidized rubredoxin + ...
Ougham, H.J.; Taylor, D.G.; Trudgill, P.W. (1983). "Camphor revisited: involvement of a unique monooxygenase in metabolism of 2 ... 2-monooxygenase, OTEMO) is an enzyme with systematic name ((1R)-2,2,3-trimethyl-5-oxocyclopent-3-enyl)acetyl-CoA,NADPH:oxygen ... "Completing the series of BVMOs involved in camphor metabolism of Pseudomonas putida NCIMB 10007 by identification of the two ... and structures of the camphor pathway 2-oxo-Δ3-4,5,5-trimethylcyclopentenylacetyl-coenzyme A monooxygenase of Pseudomonas ...
H2O Camphor 6-endo-hydroxylase is a cytochrome P450 monooxygenase from the bacterium Rhodococcus sp. NCIMB 9784. Grogan, G.; ... Camphor 6-endo-hydroxylase (EC 1.14.15.10, P450camr) is an enzyme with systematic name (+)-camphor,reduced putidaredoxin:oxygen ... camphor 6-endo-hydroxylase at the US National Library of Medicine Medical Subject Headings (MeSH) Molecular and Cellular ... camphor". Appl. Microbiol. Biotechnol. 59 (4-5): 449-454. doi:10.1007/s00253-002-1054-0. PMID 12172608. ( )- ...
... camphor 1,2-monooxygenase EC 1.14.15.3: alkane 1-monooxygenase EC 1.14.15.4: steroid 11b-monooxygenase EC 1.14.15.5: ... steroid 15beta-monooxygenase EC 1.14.15.9: spheroidene monooxygenase EC 1.14.15.10: (+)-camphor 6-endo-hydroxylase EC 1.14. ... alpha-pinene monooxygenase EC 1.14.13.156: 1,8-cineole 2-endo-monooxygenase EC 1.14.13.157: 1,8-cineole 2-exo-monooxygenase EC ... menthol monooxygenase EC 1.14.13.47: (S)-limonene 3-monooxygenase EC 1.14.13.48: (S)-limonene 6-monooxygenase EC 1.14.13.49: (S ...
Baeyer-Villiger monooxygenases (BVMOs) use dioxygen to perform the Baeyer-Villiger oxidation. These enzymes are capable of ... They used peroxymonosulfuric acid to make the corresponding lactones from camphor, menthone, and tetrahydrocarvone. There were ... agent testololactone by use of a Baeyer-Villiger oxidation induced by fungus that produces Baeyer-Villiger monooxygenases. ... ISBN 978-0-393-93149-5. Evans, D. A. "Stereoelectronic Effects-2" (PDF). Chemistry 206 (Fall 2006-2007). Baeyer, Adolf; ...
... menthol monooxygenase activity ... Peppermint camphor. *p-Menthan-3-ol. *Menthomenthol. * ...
This enzyme is part of a camphor-hydroxylating catalytic cycle consisting of two electron transfer steps from putidaredoxin, a ... The most common reaction catalyzed by cytochromes P450 is a monooxygenase reaction, e.g., insertion of one atom of oxygen into ... Most CYP enzymes are presumed to have monooxygenase activity, as is the case for most mammalian CYPs that have been ... "Characterization of a catalytically self-sufficient 119,000-dalton cytochrome P-450 monooxygenase induced by barbiturates in ...
The most common reaction catalyzed by cytochromes P450 is a monooxygenase reaction, e.g., insertion of one atom of oxygen into ... This enzyme is part of a camphor-hydroxylating catalytic cycle consisting of two electron transfer steps from putidaredoxin, a ... Most CYP enzymes are presumed to have monooxygenase activity, as is the case for most mammalian CYPs that have been ... 149 (5): 406-12. doi:10.1007/BF00425579.. *^ Moody SC, Zhao B, Lei L, Nelson DR, Mullins JG, Waterman MR, Kelly SL, Lamb DC ( ...
Camphor (camphor laurel, rosemary, camphorweed, African blue basil, camphor basil). *Cannabidiol (cannabis) ... Squalene monooxygenase. inhibitors. Allylamines. *Topical: naftifine. *terbinafine. Systemic: terbinafine. Benzylamines. * ... Clotrimazole is usually used 5 times daily for 14 days for oral thrush, twice daily for 2 to 8 weeks for skin infections, and ... 5] In 2016 Canesten was one of the biggest selling branded over-the-counter medications sold in Great Britain, with sales of £ ...
Oliw, Ernst H (1993). "Bis-Allylic hydroxylation of linoleic acid and arachidonic acid by human hepatic monooxygenases". ... Camphor (camphor laurel, rosemary, camphorweed, African blue basil, camphor basil). *Cannabidiol (cannabis) ... 45 (5): 482-91. doi:10.1111/imj.12736. PMID 25955461.. *^ a b Shureiqi, I; Chen, D; Day, R. S; Zuo, X; Hochman, F. L; Ross, W. ... 99 (5): 888-93. doi:10.1172/JCI119253. PMC 507896. PMID 9062346.. *^ a b Cabral, Marisol; Martín-Venegas, Raquel; Moreno, Juan ...
... monooxygenase into two molecules of vitamin A.[11] ... Betacarotene (INN), β-Carotene,[1] Food Orange 5, Provitamin A ... 72 (1): 40-5. doi:10.1024/0300-9831.72.1.40. PMID 11887751.. *^ Lakshman, MR (2004). "Alpha and omega of carotenoid cleavage". ... 13 (5): 1084-1099. doi:10.1002/hlca.19300130532.. *^ States4439629 United States expired 4439629, Rüegg, Rudolf, "Extraction ... β-Carotene is biosynthesized from geranylgeranyl pyrophosphate.[5] β-Carotene is the most common form of carotene in plants. ...
... camphor hydroxylase, d-camphor monooxygenase, methylene hydroxylase, methylene monooxygenase, D-camphor-exo-hydroxylase, and ... In enzymology, a camphor 5-monooxygenase (EC 1.14.15.1) is an enzyme that catalyzes the chemical reaction (+)-camphor + ... An induced methylene hydroxylase in camphor oxidation". J. Biol. Chem. 240 (10): 4038-43. PMID 4378858. Tyson CA, Lipscomb JD, ... The systematic name of this enzyme class is (+)-camphor,reduced putidaredoxin:oxygen oxidoreductase (5-hydroxylating). Other ...
Camphor 1,2-monooxygenase Pages 9-15 * Alkane 1-monooxygenase Pages 16-25 ...
Methane monooxygenase (MMO), found in aerobic methanotrophic bacteria, catalyzes the O2-dependent conversion of methane to ... Camphor 5-Monooxygenase Grant support * R01 GM024689/GM/NIGMS NIH HHS/United States ... Crystal structure of the hydroxylase component of methane monooxygenase from Methylosinus trichosporium OB3b Protein Sci. 1997 ... Methane monooxygenase (MMO), found in aerobic methanotrophic bacteria, catalyzes the O2-dependent conversion of methane to ...
Camphor 5-monooxygenase. MTTETIQSNANLAPLPPHVPEHLVFDFDMYNPSNLSAGVQEAWAVLQESN.... unknown. Cytochrome c. ... InChI=1S/C5H9N/c1-3-4-5-6-2/h3-5H2,1H3. ...
Description: Structure of cyanide and camphor bound P450cam mutant L358P/K178G. Class: oxidoreductase. Keywords: mono-oxygenase ... Compound: Camphor 5-monooxygenase. Species: Pseudomonas putida [TaxId:303]. Gene: CAMC, CYP101. Database cross-references and ...
Compound: Camphor 5-monooxygenase. Species: Pseudomonas putida [TaxId:303]. Gene: CAMC, CYP101. Database cross-references and ... Keywords: Cytochrome P450, P450cam, camphor, tethered substrate analog, open conformation, OXIDOREDUCTASE. Deposited on 2010-10 ...
Compound: Camphor 5-monooxygenase. Species: Pseudomonas putida [TaxId:303]. Gene: CAMC, CYP101. Database cross-references and ... Compound: Camphor 5-monooxygenase. Species: Pseudomonas putida [TaxId:303]. Gene: CAMC, CYP101. Database cross-references and ...
1997) Probing the interactions of putidaredoxin with redox partners in camphor P450 5-monooxygenase by mutagenesis of surface ... is the most comprehensively studied member of the ubiquitous superfamily of cytochromes P450-heme-containing monooxygenases ... 1 mM camphor, and 7% (vol/vol) D2O; 2D 15N-1H HSQC and 15N-1H TROSY spectra (54) were recorded at 290 K on a Bruker Avance III ... 1 mM camphor, 1% (vol/vol) MeOH, and 6% (vol/vol) D2O. The eluted brown fractions were pooled and concentrated. Approximately ...
... camphor 1,2-monooxygenase, camphor ketolactonase I) is an enzyme with systematic name (+)-bornane-2,5-dione,NADH:oxygen ... 2-monooxygenase from the camphor metabolizing Pseudomonas putida strain NCIMB 10007". AMB Express. 1 (1): #13-13. doi:10.1186/ ... monooxygenases from camphor-grown Pseudomonas putida ATCC 17453". J. Gen. Microbiol. 139 (4): 797-805. doi:10.1099/00221287-139 ... Camphor ketolactonase I and the role of three protein components". J. Biol. Chem. 244 (22): 6149-6152. PMID 4310834. Taylor, D. ...
... camphor 5-monooxygenase MeSH D12.776.422.220.453.915 - steroid hydroxylases MeSH D12.776.422.220.453.915.050 - aldosterone ... tyrosine 3-monooxygenase MeSH D12.776.575.750.500.100 - adenine nucleotide translocator 1 MeSH D12.776.575.750.500.200 - ... cyclin-dependent kinase 5 MeSH D12.776.167.200.067.900 - cyclin-dependent kinase 9 MeSH D12.776.167.200.580.500 - cdc2 protein ... myogenic regulatory factor 5 MeSH D12.776.210.500.570.600 - myogenin MeSH D12.776.210.500.600.100 - myosin heavy chains MeSH ...
4-hydroxybenzoate 3-monooxygenase MeSH D08.811.682.690.708.557 --- kynurenine 3-monooxygenase MeSH D08.811.682.690.708.601 --- ... camphor 5-monooxygenase MeSH D08.244.453.915 --- steroid hydroxylases MeSH D08.244.453.915.050 --- aldosterone synthase MeSH ... trans-cinnamate 4-monooxygenase MeSH D08.622.509.700 --- pepsinogen a MeSH D08.622.509.725 --- pepsinogen c MeSH D08.622. ... monophenol monooxygenase MeSH D08.811.682.690.708.170 --- cytochrome p-450 enzyme system MeSH D08.811.682.690.708.170.040 --- ...
Ougham, H.J.; Taylor, D.G.; Trudgill, P.W. (1983). "Camphor revisited: involvement of a unique monooxygenase in metabolism of 2 ... 2,2,3-trimethyl-5-oxocyclopent-3-enyl)acetyl-CoA synthase at the US National Library of Medicine Medical Subject Headings (MeSH ... 2,2,3-trimethyl-5-oxocyclopent-3-enyl)acetyl-CoA synthase (EC 6.2.1.38, 2-oxo-Delta3-4,5,5-trimethylcyclopentenylacetyl-CoA ... Δ3-4,5,5-trimethylcyclopentenylacetic acid by Pseudomonas putida". J. Bacteriol. 153 (1): 140-152. PMC 217351 . PMID 6848481. ( ...
Figure 3 is CYP P450cam(CYP101A1: Cytochrome P450 camphor 5-monooxygenase), which is the first discovery of CYP P450 and they ... Cytochrome P450(CYP) is a monooxygenase and heme-containing enzyme found in the endoplasmic reticulum(ER) membrane. CYPs have ... Molecular evolutionary dynamics of cytochrome P450 monooxygenases across kingdoms: Special focus on mycobacterial P450s. ... There are 5 major Cytochromes(Figure 10) that are CYP3A4, 2C9, 2C19, 2D6, 1A2. Sequence similarity among those does not ...
DSSYKIVIOFKYAU-UHFFFAOYSA-N Camphor Chemical compound data:image/svg+xml;base64, ... TWVJWDMOZJXUID-SDDRHHMPSA-N 2-[(3S,5R,8S)-3,8-dimethyl-1,2,3,4,5,6,7,8-octahydroazulen-5-yl]propan-2-ol Chemical compound data: ... MDXGVXXPPQSIHA-QFUQLDCJSA-N 2-[(3S,5S,8S)-4-fluoro-3,8-dimethyl-1,2,3,4,5,6,7,8-octahydroazulen-5-yl]propan-2-ol Chemical ... DFFOSEJNFZUOSK-UHFFFAOYSA-N 2-[2-[2-(4-phenoxy-2-propylphenoxy)ethyl]-1H-indol-5-yl]acetic acid Chemical class data:image/svg+ ...
Camphor 5-monooxygenase (substance). Code System Preferred Concept Name. Camphor 5-monooxygenase (substance). ...
In enzymology, a camphor 1,2-monooxygenase (EC 1.14.15.2) is an enzyme that catalyzes the chemical reaction (+)-bornane-2,5- ... camphor ketolactonase I, oxygenase, camphor 1,2-mono, and ketolactonase I. It employs one cofactor, iron. CONRAD HE, DUBUS R, ... Camphor ketolactonase I and the role of three protein components". J. Biol. Chem. 244 (22): 6149-52. PMID 4310834. Molecular ... Purification of a tightly coupled electron transport complex in camphor lactonization". J. Biol. Chem. 241 (18): 4288-90. PMID ...
"Functional Assembly of camphor converting two-component Baeyer-Villiger monooxygenases with a flavin reductase from E. coli". ... 5: 25. doi:10.3389/fmicb.2014.00025. PMC 3915288 . PMID 24567729. Kadow M, Balke K, Willetts A, Bornscheuer UT, Bäckvall JE (5 ... 5 (3): 985-97. doi:10.3390/cancers5030985. PMC 3795375 . PMID 24202330. Paine MJ, Garner AP, Powell D, Sibbald J, Sales M, ...
monooxygenase, C-B bond cleavage. Graphic (18k). Propylene oxide ------ Acetoacetate. carboxylase, NAD+, NADPH. Graphic (17k ... Camphor ------ 5-exo-Hydroxycamphor monooxygenase, P450cam, stereospecific hydroxylation. Graphic (16k). Carbonyl sulfide ... monooxygenase, epoxidation, FAD, NAD(P). Graphic (11k). Styrene oxide -- Phenylacetaldehyde. isomerase, oxirane opening. ... monooxygenase, NADP, FAD, Baeyer Villiger oxidation. Graphic (14k). 2,5-Dichlorohydroquinone -- Chlorohydroquinone. ...
van Gorkom, H. J. & Schelvis, J. P. M., 1 Jan 1993, In : Photosynthesis Research. 38, 3, p. 297-301 5 p.. Research output: ... Zhao, Y., Brandish, P. E., DiValentin, M., Schelvis, J. P. M., Babcock, G. T. & Marletta, M. A., 5 Sep 2000, In : Biochemistry. ... Contributions of the 8-methyl group to the vibrational normal modes of flavin mononucleotide and its 5-methyl semiquinone ... 165-169 5 p.. Research output: Contribution to journal › Article ...
Catalytic function of the mycobacterial binuclear iron monooxygenase in acetone metabolism. Furuya, T., Nakao, T. & Kino, K., ... Identification of the monooxygenase gene clusters responsible for the regioselective oxidation of phenol to hydroquinone in ... Efficient monooxygenase-catalyzed piceatannol production: Application of cyclodextrins for reducing product inhibition. Furuya ... Reconstitution of active mycobacterial binuclear iron monooxygenase complex in escherichia coli. Furuya, T., Hayashi, M. & Kino ...
Niece, B. K. & Gewirth, A. A., Oct 2 1996, In : Langmuir. 12, 20, p. 4909-4913 5 p.. Research output: Contribution to journal ... Camphor Probing the interaction between single molecules: fluorescence resonance energy transfer between a single donor and a ... Gutiérrez, R., Jan 1 1996, In : Journal of Curriculum Studies. 28, 5, p. 495-529 35 p.. Research output: Contribution to ... Johnston, M. & Kerper, R. M., Jan 1 1996, In : Curriculum Inquiry. 26, 1, p. 5-24 20 p.. Research output: Contribution to ...
Fingerprint The Elsevier Fingerprint Engine mines the text of the experts scholarly documents - publication abstracts, awards, project summaries, patents, and other sources - to create an index of weighted terms which defines the text, known as a Fingerprint. By aggregating and comparing Fingerprints, the Elsevier Fingerprint Engine enables users to look beyond metadata and expose valuable connections among people, research units, publications, and ideas. ...
The crystallographic structure of ferrous camphor- and carbon monoxide-bound P-450CAM (Raag & Poulos, 1989b) suggests that ... Specifically, hydrogen peroxide and "excess" water are produced instead of the product, 5-exo-hydroxycamphor. The X-ray ...
TY - JOUR. T1 - Essential role of the Arg112 residue of cytochrome P450cam for electron transfer from reduced putidaredoxin. AU - Koga, Hideo. AU - Sagara, Yasuhiro. AU - Yaoi, Tsuyoshi. AU - Tsujimura, Mitsushi. AU - Nakamura, Kazuhide. AU - Sekimizu, Kazuhisa. AU - Makino, Ryu. AU - Shimada, Hideo. AU - Ishimura, Yuzuru. AU - Yura, Kei. AU - Go, Mitiko. AU - Ikeguchi, Masamichi. AU - Horiuchi, Tadao. PY - 1993/9/27. Y1 - 1993/9/27. N2 - Cytochrome P450cam (CYP101) of Pseudomonas putida PpGl in which Arg112 is substituted by Cys was isolated by in vitro random mutagenesis of the camC gene DNA coding for P450cam. The absorption spectra of the purified mutant enzyme were similar to those of the wild type enzyme, but its substrate-dependent NADH oxidation activity in the presence of putidaredoxin (Pd) and putidaredoxin reductase (PdR) was extremely low. The rate constant of electron transfer from reduced Pd to the heme of the mutant P450cam, measured on an anaerobic stopped flow apparatus, was 1 ...
2-monooxygenase from the camphor metabolizing Pseudomonas putida strain NCIMB 10007". ... Xem 1-18 trên 18 kết quả Monooxygenases. * Báo cáo khoa học: The role of cytochrome P450 monooxygenases in microbial fatty acid ... The Baeyer-Villiger monooxygenase (BVMO), 4-hydroxy-acetophenone monooxygenase (HAPMO), uses NADPH andO2 to oxidize a variety ... 2-monooxygenase from the camphor metabolizing Pseudomonas putida strain NCIMB 10007 ...
  • 2,2,3-trimethyl-5-oxocyclopent-3-enyl)acetyl-CoA synthase (EC 6.2.1.38, 2-oxo-Delta3-4,5,5-trimethylcyclopentenylacetyl-CoA synthetase) is an enzyme with systematic name ((1R)-2,2,3-trimethyl-5-oxocyclopent-3-enyl)acetate:CoA ligase (AMP-forming). (wikipedia.org)
  • Bansal S, Narnoliya LK, Mishra B, Chandra M, Yadav RK, Sangwan NS (2018) HMG-CoA reductase from Camphor Tulsi ( Ocimum kilimandscharicum ) regulated MVA dependent biosynthesis of diverse terpenoids in homologous and heterologous plant systems. (springer.com)
  • In vertebrates, peptide amidation is catalyzed by two enzymes [peptidylglycine a-hydroxylating monooxygenase (PHM) and peptidyl-a-hydroxylglycinea-amidating lyase] acting sequentially. (tailieu.vn)
  • The bound substrate induces a change in the conformation of the active site, often displacing a water molecule from the distal axial coordination position of the heme iron [5] , and sometimes changing the state of the heme iron from low-spin to high-spin . (wikidoc.org)
  • 1993). Camphor was administered in the form of aromatic vapor, at the concentrations of 50, 133 and 500 µg l -1 , to guinea pigs subject to chemically induced cough. (bioline.org.br)
  • Agarwal R, Wang ZY, Bik DP, Mukhtar H (1991) Nordihydroguaiaretic acid, an inhibitor of lipoxygenase, also inhibits cytochrome P-450-mediated monooxygenase activity in rat epidermal and hepatic microsomes. (springer.com)
  • 1989). Camphor is today mostly used in the form of inhalants and of camphorated oil, a preparation of 19% or 20% camphor in a carrier oil, for the home treatment of colds (Jochen and Theis, 1995) and as a major active ingredient of liniments and balms used as topical analgesics (Xu et al. (bioline.org.br)
  • 2005). The antitussive, nasal decongestant and expectorant action of camphor and of its derivatives was one of the first ones to be systematically investigated (Inoue and Takeuchi, 1969). (bioline.org.br)
  • 5. The nutraceutical composition of Claim 2, wherein the collagen peptides are produced by digestion by at least one enzyme selected from papain, pepsin, bromelain, trypsin, bacterial protease, fungal protease and pancreatin. (sumobrain.com)
  • 2005) demonstrated that camphor activates TRPV3, a member of transient receptor channel superfamily, leading to excitation and desensitization of sensory nerves. (bioline.org.br)
  • The crystallographic structure of ferrous camphor- and carbon monoxide-bound P-450CAM (Raag & Poulos, 1989b) suggests that Thr252 is a key active site residue, forming part of the dioxygen-binding site. (nih.gov)
  • In its ferrous state, it binds to the inhibitor carbon monoxide (CO) to give a Fe II -CO complex in which the major (Soret) absorbance band lies at ∼450 nm - i.e. pigment (with absorption peak at 450 nm) [ 5 , 6 ]. (biochemsoctrans.org)
  • 1994). The analgesic proprieties of camphor are largely known and applied, but little is known about the molecular mechanisms that are at their basis. (bioline.org.br)
  • The inhalation of camphor vapours (so as the one of eucalyptus and menthol vapours) on a sample of volunteers increased the nasal sensation of airflow through the induction of cold sensation in the nose, despite of actually not affecting nasal resistance to airflow (Buroow et al. (bioline.org.br)
  • Camphor has a counter-irritant, rubefacient and mild analgesic action, and is a major component of liniments for relief of fibrositis, neuralgia and similar conditions. (bioline.org.br)
  • The general conclusion is that the main risks of camphor as a medicinal product are mainly due to a somehow diffused attitude of considering it as 'not a real medicine', and to its consequent sometimes not sufficiently careful administration. (researchgate.net)
  • The online version of this article ( https://doi.org/10.1186/s13068-018-1218-5 ) contains supplementary material, which is available to authorized users. (springer.com)
  • 5% whey-protein solutions were preheated at pH7 and at various temperatures(60~8 $0^{\circ}C$ ) for 15 minutes. (koreascience.or.kr)
  • The main aspects of the non-clinical profile of D-camphor, a natural product widely used as a common remedy for several symptoms, are reviewed. (researchgate.net)