A nematocide effective against a variety of gastrointestinal parasites in cattle, sheep, and horses.

Genetic variability of the beta-tubulin genes in benzimidazole-susceptible and -resistant strains of Haemonchus contortus. (1/1)

Benzimidazole anthelmintics are the most common chemotherapeutic agents used to remove intestinal helminths from farm animals. The development of drug resistance within helminth populations is wide-spread and can render these drugs essentially useless. The mechanism of benzimidazole resistance appears to be common to many species ranging from fungi to nematodes and involves alterations in the genes encoding beta-tubulin. During the selection process resulting in resistance, there must be quantitative changes in the population gene pool. Knowledge of these changes would indicate the mechanisms underlying the spread of resistance in the population, which in turn could be used to design more effective drug administration strategies. To this end we have identified allelic variation at two beta-tubulin genes in Haemonchus contortus using restriction map analysis of individual adults. Extremely high levels of variation were identified at both loci within a susceptible strain. In two independently derived benzimidazole resistant strains, allele frequencies at both loci were significantly different from the susceptible strain but not from each other. The same alleles at both loci, in both resistant strains, were favored by selection with benzimidazoles, suggesting that both loci are involved in determining benzimidazole resistance. These data confirm that changes in allele frequency, rather than novel genetic rearrangements induced by exposure to the drug, explain the changes associated with benzimidazole resistance. These results also show that any DNA based test for the development of benzimidazole resistance must take into account the frequency of alleles present in the population and not simply test for the presence or absence of specific allelic types.  (+info)

Cambendazole is an anthelmintic drug, which means it is used to treat parasitic worm infections. It works by inhibiting the tubulin polymerization of the parasitic worms, leading to their death. Cambendazole is effective against a variety of gastrointestinal roundworms and lung worms in animals, and it is commonly used in veterinary medicine.

Human use of cambendazole is limited, and it is not approved by the U.S. Food and Drug Administration (FDA) for use in humans. However, it has been used off-label to treat certain parasitic worm infections in humans, such as strongyloidiasis and cutaneous larva migrans. As with any medication, cambendazole should only be used under the supervision of a healthcare provider, and its use may be associated with side effects such as nausea, vomiting, and abdominal pain.

A number of derivatives of tiabendazole are also pharmaceutical drugs, including albendazole, cambendazole, fenbendazole, ...
The level of control with three treatments of cambendazole on days 3-4, 6-7, and 16-17 post-infection was 94.9% in chickens and ...
... cambendazole MeSH D03.438.103.370 - domperidone MeSH D03.438.103.393 - droperidol MeSH D03.438.103.450 - fenbendazole MeSH ...
... cambendazole (INN) Cambia Camcevi camiglibose (INN) Camila camiverine (INN) camobucol (USAN, INN) camonagrel (INN) Camoquin ...
QP52AC03 Parbendazole QP52AC04 Thiophanate QP52AC05 Febantel QP52AC06 Netobimine QP52AC07 Oxibendazole QP52AC08 Cambendazole ...
... agents Barbiturates Benzodiazepines Bupropion Beta-2 agonists Beta blockers CYP1A2 inhibitors CYP1A2 inducers Cambendazole ...
Treatment for lagochilascariasis involves thiabendazole, cambendazole, mebendazole, albendazole, praziquantel, and invermectine ...
A number of derivatives of tiabendazole are also pharmaceutical drugs, including albendazole, cambendazole, fenbendazole, ...
Do not use any cambendazole deworming products for the 1st trimester.. Mare Management. Mommy care tips. *Monitor your mares ...
Ef f ecst-ivenes sof Cambendazole in Experimeatal Infectiona of! Cattle with Ostertatl,a and Cooperia TIERAERZtLICHE U14.1 ...
Cambendazole. Analytical standard, reference material (Fluka). 10MG. 197 EUR. R1036. Carbendazim-d3. Analytical standard, ...
Cambendazole. ,0.1. Tag: pesticide test kit, pesticide residue analysis, pesticides elisa kits ...
cambendazole (usan). *cambenzole. *camdan. *camvet. *carbamic acid, (2-(4-thiazolyl)-1h-benzimidazol-5-yl)-, 1-methylethyl ...
Most of the positive test results were in dogs less than 2 years of age; 33.5% had Odz3 been Cambendazole previously vaccinated ... Using an average of published estimates for other urban areas of Chile (Vi?a del Mar: 0.95 [21]; Cambendazole Santiago: 0.76 [ ... Of the 208 physical exams in April and May, 45 dogs experienced at least one of the nine Cambendazole CDV indicators, and ... Information from Cambendazole physical exams showed similar findings. ...
Cambendazole oviducts of female mice of the indicated genotype. B: blastocyst; M: morula; 4/8: 4/8 cell stage. E) Validation of ... At 12 and 33 weeks of age, however, WT and p110D931A/D931A mice experienced a similar body Cambendazole weight (D). A) ...
One unit (U) is defined as the amount of enzyme that Cambendazole catalyzes the formation of 1 mol NADPH per minute under the ... Desired mutations and the entire sequences of Cambendazole the np-Ga3PDHases were verified by double-stranded DNA sequencing. ... Unless Cambendazole otherwise specified, enzymatic reactions were performed in a final volume of 20 L with 2 Ci of [32P]-ATP ( ... and autoradiographed on x-ray Cambendazole films (Kodak) at ?80C for 16 h. As an alternative to x-ray films, radioactivity ...
2013 Hammen and colleagues (2000) found that females with contact Cambendazole with years as a child adversities had a lesser ... may Cambendazole be related to alterations in the brain which mediates the effects of external stressors on internal ... extended these investigations to examine risk of major depression and also anxiety disorders finding Cambendazole that the risk ... predict subsequent increases in symptoms of stress and depression as well as clinical disorder after exposure to Cambendazole ...
In this review we will focus on the epigenetic mechanisms for Cambendazole the expression of TFs cytokines matrix proteinases ... Introduction Osteoarthritis (OA) is the most common form of arthritis in the US and affects Cambendazole approximately 27 ... has long been thought of as a mechanical issue.2 However there is a growing body of evidence supporting the notion Cambendazole ... ncRNAs has revealed the importance of ncRNAs in development and diseases.14 15 Given the importance of epigenetics Cambendazole ...
Cambendazole D3.438.103.190 D3.633.100.103.190 Camelids, New World B1.50.150.900.649.77.380.175 B1.50.150.900.649.77.190.90 ...
Cambendazole D3.438.103.190 D3.633.100.103.190 Camelids, New World B1.50.150.900.649.77.380.175 B1.50.150.900.649.77.190.90 ...
Cambendazole D3.438.103.190 D3.633.100.103.190 Camelids, New World B1.50.150.900.649.77.380.175 B1.50.150.900.649.77.190.90 ...
Cambendazole D3.438.103.190 D3.633.100.103.190 Camelids, New World B1.50.150.900.649.77.380.175 B1.50.150.900.649.77.190.90 ...
Cambendazole D3.438.103.190 D3.633.100.103.190 Camelids, New World B1.50.150.900.649.77.380.175 B1.50.150.900.649.77.190.90 ...
"પ્રતિકૂળ અસરો Teratogenic અસરો Albendazole, cambendazole, oxfendazole અને parbendazole માટે દર્શાવવામાં આવી છે, જો આ દવાઓનો ... Albendazole, cambendazole, oxfendazole અને parbendazole માટે ટેરેટોજેનિક અસરો દર્શાવવામાં આવી છે, જો આ દવાઓનો ઉપયોગ પ્રારંભિક ...
Several wormers, including thiabendazole, fenbendazole, cambendazole, pyrantel, Prevention and control of parasites is one of ...
... parbendazole and cambendazole), i.e. it can cause malformations in the embryos and therefore should not be administered to ...
2-Substituted benzimidazole first introduced in 1962. It is active against a variety of nematodes and is the drug of choice for STRONGYLOIDIASIS. It has CENTRAL NERVOUS SYSTEM side effects and hepatototoxic potential. (From Smith and Reynard, Textbook of Pharmacology, 1992, p919 ...
Surgical drainage and administration of cambendazole and levamisole led to i … ... Surgical drainage and administration of cambendazole and levamisole led to improvement, followed by an early relapse and poor ...
Cambendazole against Strongyloïdes westeri; Pyrantel embonate, Cambendazole and Dichlorvos against Parascaris equorum; and ... Critical anthelmintic trials in ponies with four benzimidazoles: mebendazole, cambendazole, fenbendazole, and albendazole. ... 20 mg/kg for Cambendazole and 7 mg/kg for Parbendazole. From 6 to 9 ponies were treated with each of these anthelmintic agents ... Albendazole and Cambendazole; group 3, with Parbendazole, Fenbendazole et Dichlorvos. Results with large strongyles sometimes ...
CAMBENDAZOLE. CANDICIDINS, THEIR SALTS AND. DERIVATIVES. CAPREOMYCIN, ITS SALTS AND. DERIVATIVES. CAPTODIAMINE AND ITS SALTS. ...
Cambendazole,create,22-AUG-08,(null),(null) C75213,Clorsulon,create,22-AUG-08,(null),(null) C75214,Crufomate,create,22-AUG-08,( ...
Cambendazole. Nathan Mantel Papers, MS C 610. Archives and Modern Manuscripts Collection. ... Cambendazole. Nathan Mantel Papers, MS C 610. Archives and Modern Manuscripts Collection. https://findingaids.nlm.nih.gov/ ...
Cambendazole D3.438.103.190 D3.633.100.103.190 Camelids, New World B1.50.150.900.649.77.380.175 B1.50.150.900.649.77.190.90 ...
Cambendazole Preferred Term Term UI T006175. Date01/01/1999. LexicalTag NON. ThesaurusID ... Cambendazole Preferred Concept UI. M0003231. Registry Number. 079X63S3DU. Related Numbers. 26097-80-3. Scope Note. A nematocide ... Cambendazole. Tree Number(s). D03.633.100.103.190. Unique ID. D002159. RDF Unique Identifier. http://id.nlm.nih.gov/mesh/ ...
Cambendazole Preferred Term Term UI T006175. Date01/01/1999. LexicalTag NON. ThesaurusID ... Cambendazole Preferred Concept UI. M0003231. Registry Number. 079X63S3DU. Related Numbers. 26097-80-3. Scope Note. A nematocide ... Cambendazole. Tree Number(s). D03.633.100.103.190. Unique ID. D002159. RDF Unique Identifier. http://id.nlm.nih.gov/mesh/ ...
Welker DL, Williams KL Mitotic arrest and chromosome doubling using thabenda- zole, cambendazole, nocodazole and ben late in ...
Cambendazole (substance). Code System Preferred Concept Name. Cambendazole (substance). Concept Status. Published. ...
... cambendazole, E0300713,Levorin,Calcium levofolinate, E0300714,Vanobid,Candicidin, E0300718,Soldactone,canrenoate potassium, ...
Treatment for lagochilascariasis involves thiabendazole, cambendazole, mebendazole, albendazole, praziquantel, and invermectine ...
lsqb;0061] antihelminthics, such as albendazole, bephenium hydroxynaphthoate, cambendazole, dichlorophen, ivermectin, ...
Cambendazole. Methyl Cellosolve® Acetate. Pramiverin. Iproclozide. Hexachloroethane. Deaminooxytocin. Benzil. Interleukin-4. ...
ANTI-INFECTIVE AGENTS CAMBENDAZOLE ANTI-INFECTIVE AGENTS CAMPHOR ANTI-INFECTIVE AGENTS CANDICIDIN ANTI-INFECTIVE AGENTS ... ANTINEMATODAL AGENTS CAMBENDAZOLE ANTINEMATODAL AGENTS CARBOFURAN ANTINEMATODAL AGENTS COUMAPHOS ANTINEMATODAL AGENTS ... ANTIPARASITIC AGENTS CAMBENDAZOLE ANTIPARASITIC AGENTS CARBOFURAN ANTIPARASITIC AGENTS CHLOROGUANIDE ANTIPARASITIC AGENTS ... ANTHELMINTICS CAMBENDAZOLE ANTHELMINTICS CARBOFURAN ANTHELMINTICS COUMAPHOS ANTHELMINTICS DIAMFENETIDE ANTHELMINTICS ...
Cambendazole D3.438.103.190 D3.633.100.103.190 Camelids, New World B1.50.150.900.649.77.380.175 B1.50.150.900.649.77.190.90 ...
This graph shows the total number of publications written about "Domperidone" by people in this website by year, and whether "Domperidone" was a major or minor topic of these publications ...
This graph shows the total number of publications written about "Mebendazole" by people in this website by year, and whether "Mebendazole" was a major or minor topic of these publications ...
Ogilvie BW, Yerino P, Kazmi F, Buckley DB, Rostami-Hodjegan A, Paris BL, Toren P, Parkinson A. The proton pump inhibitor, omeprazole, but not lansoprazole or pantoprazole, is a metabolism-dependent inhibitor of CYP2C19: implications for coadministration with clopidogrel. Drug Metab Dispos. 2011 Nov; 39(11):2020-33 ...
  • Albendazole, cambendazole, oxfendazole અને parbendazole માટે ટેરેટોજેનિક અસરો દર્શાવવામાં આવી છે, જો આ દવાઓનો ઉપયોગ પ્રારંભિક ગર્ભાવસ્થામાં કરવો હોય, તો તે યોગ્ય કારણોસર અને ભલામણ કરેલ સૌથી ઓછી માત્રામાં હોવી જોઈએ. (veyongpharma.com)
  • 2013 Hammen and colleagues (2000) found that females with contact Cambendazole with years as a child adversities had a lesser threshold for creating a depressive a reaction to stressors. (molecularcircuit.com)
  • McLaughlin and coworkers (2010) extended these investigations to examine risk of major depression and also anxiety disorders finding Cambendazole that the risk for psychopathology after past-year major stressors was nearly doubled for individuals with a history of child years adversity compared to those without such a history. (molecularcircuit.com)
  • This is shown by comparing results of critical tests conducted with 9 anthelmintic agents on ponies using the following dosages: 19 mg/kg for Pyrantel embonate, 10 mg/kg for Oxfendazole, 10 mg/kg for Mebendazole, 5 mg/kg for Albendazole, 40 mg/kg for Dichlorvos, 44 mg/kg for Thiabendazole, 7.5 mg/kg, for Fenbendazole, 20 mg/kg for Cambendazole and 7 mg/kg for Parbendazole. (nih.gov)