Calorimetry, Differential Scanning
Calorimetry
The measurement of the quantity of heat involved in various processes, such as chemical reactions, changes of state, and formations of solutions, or in the determination of the heat capacities of substances. The fundamental unit of measurement is the joule or the calorie (4.184 joules). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Calorimetry, Indirect
Thermodynamics
A rigorously mathematical analysis of energy relationships (heat, work, temperature, and equilibrium). It describes systems whose states are determined by thermal parameters, such as temperature, in addition to mechanical and electromagnetic parameters. (From Hawley's Condensed Chemical Dictionary, 12th ed)
Energy Metabolism
Basal Metabolism
Heat production, or its measurement, of an organism at the lowest level of cell chemistry in an inactive, awake, fasting state. It may be determined directly by means of a calorimeter or indirectly by calculating the heat production from an analysis of the end products of oxidation within the organism or from the amount of oxygen utilized.
Temperature
Titrimetry
The determination of the concentration of a given component in solution (the analyte) by addition of a liquid reagent of known strength (the titrant) until an equivalence point is reached (when the reactants are present in stoichiometric proportions). Often an indicator is added to make the equivalence point visible (e.g., a change in color).
Protein Denaturation
X-Ray Diffraction
The scattering of x-rays by matter, especially crystals, with accompanying variation in intensity due to interference effects. Analysis of the crystal structure of materials is performed by passing x-rays through them and registering the diffraction image of the rays (CRYSTALLOGRAPHY, X-RAY). (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Circular Dichroism
Spectroscopy, Fourier Transform Infrared
1,2-Dipalmitoylphosphatidylcholine
Lipid Bilayers
Transition Temperature
Protein Binding
Models, Molecular
Technology, Pharmaceutical
The application of scientific knowledge or technology to pharmacy and the pharmaceutical industry. It includes methods, techniques, and instrumentation in the manufacture, preparation, compounding, dispensing, packaging, and storing of drugs and other preparations used in diagnostic and determinative procedures, and in the treatment of patients.
Powder Diffraction
Dimyristoylphosphatidylcholine
Chemistry, Pharmaceutical
Solubility
Water
Protein Conformation
The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain).
Thermogravimetry
Entropy
Magnetic Resonance Spectroscopy
Drug Compounding
Phosphatidylcholines
Binding Sites
Crystallography, X-Ray
Protein Structure, Secondary
Protein Structure, Tertiary
The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.
Body Composition
Body Temperature Regulation
Excipients
Drug Carriers
Forms to which substances are incorporated to improve the delivery and the effectiveness of drugs. Drug carriers are used in drug-delivery systems such as the controlled-release technology to prolong in vivo drug actions, decrease drug metabolism, and reduce drug toxicity. Carriers are also used in designs to increase the effectiveness of drug delivery to the target sites of pharmacological actions. Liposomes, albumin microspheres, soluble synthetic polymers, DNA complexes, protein-drug conjugates, and carrier erythrocytes among others have been employed as biodegradable drug carriers.
Liposomes
Hydrogen-Ion Concentration
Oxygen Consumption
Models, Chemical
Enzyme Stability
Nuclear Magnetic Resonance, Biomolecular
Powders
Phosphatidylethanolamines
Phosphatidylglycerols
Carbonic Anhydrase II
Amino Acid Sequence
Membranes, Artificial
Spectrophotometry, Ultraviolet
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
beta-Cyclodextrins
Molecular Structure
Ligands
A molecule that binds to another molecule, used especially to refer to a small molecule that binds specifically to a larger molecule, e.g., an antigen binding to an antibody, a hormone or neurotransmitter binding to a receptor, or a substrate or allosteric effector binding to an enzyme. Ligands are also molecules that donate or accept a pair of electrons to form a coordinate covalent bond with the central metal atom of a coordination complex. (From Dorland, 27th ed)
Scattering, Radiation
Membrane Fluidity
Oxidation-Reduction
A chemical reaction in which an electron is transferred from one molecule to another. The electron-donating molecule is the reducing agent or reductant; the electron-accepting molecule is the oxidizing agent or oxidant. Reducing and oxidizing agents function as conjugate reductant-oxidant pairs or redox pairs (Lehninger, Principles of Biochemistry, 1982, p471).
Crystallization
Freeze Drying
Povidone
Micelles
Particles consisting of aggregates of molecules held loosely together by secondary bonds. The surface of micelles are usually comprised of amphiphatic compounds that are oriented in a way that minimizes the energy of interaction between the micelle and its environment. Liquids that contain large numbers of suspended micelles are referred to as EMULSIONS.
Membrane Lipids
Lipids, predominantly phospholipids, cholesterol and small amounts of glycolipids found in membranes including cellular and intracellular membranes. These lipids may be arranged in bilayers in the membranes with integral proteins between the layers and peripheral proteins attached to the outside. Membrane lipids are required for active transport, several enzymatic activities and membrane formation.
Spectrophotometry, Infrared
Hydrophobic and Hydrophilic Interactions
Surface Plasmon Resonance
A biosensing technique in which biomolecules capable of binding to specific analytes or ligands are first immobilized on one side of a metallic film. Light is then focused on the opposite side of the film to excite the surface plasmons, that is, the oscillations of free electrons propagating along the film's surface. The refractive index of light reflecting off this surface is measured. When the immobilized biomolecules are bound by their ligands, an alteration in surface plasmons on the opposite side of the film is created which is directly proportional to the change in bound, or adsorbed, mass. Binding is measured by changes in the refractive index. The technique is used to study biomolecular interactions, such as antigen-antibody binding.
Carbohydrate Metabolism
Microscopy, Electron, Scanning
Microscopy in which the object is examined directly by an electron beam scanning the specimen point-by-point. The image is constructed by detecting the products of specimen interactions that are projected above the plane of the sample, such as backscattered electrons. Although SCANNING TRANSMISSION ELECTRON MICROSCOPY also scans the specimen point by point with the electron beam, the image is constructed by detecting the electrons, or their interaction products that are transmitted through the sample plane, so that is a form of TRANSMISSION ELECTRON MICROSCOPY.
Sphingomyelins
Gels
Physicochemical Phenomena
Chemistry, Physical
Poloxamer
A nonionic polyoxyethylene-polyoxypropylene block co-polymer with the general formula HO(C2H4O)a(-C3H6O)b(C2H4O)aH. It is available in different grades which vary from liquids to solids. It is used as an emulsifying agent, solubilizing agent, surfactant, and wetting agent for antibiotics. Poloxamer is also used in ointment and suppository bases and as a tablet binder or coater. (Martindale The Extra Pharmacopoeia, 31st ed)
Fluorescence Polarization
Measurement of the polarization of fluorescent light from solutions or microscopic specimens. It is used to provide information concerning molecular size, shape, and conformation, molecular anisotropy, electronic energy transfer, molecular interaction, including dye and coenzyme binding, and the antigen-antibody reaction.
Fats
The glyceryl esters of a fatty acid, or of a mixture of fatty acids. They are generally odorless, colorless, and tasteless if pure, but they may be flavored according to origin. Fats are insoluble in water, soluble in most organic solvents. They occur in animal and vegetable tissue and are generally obtained by boiling or by extraction under pressure. They are important in the diet (DIETARY FATS) as a source of energy. (Grant & Hackh's Chemical Dictionary, 5th ed)
Delayed-Action Preparations
Escherichia coli
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.
Protein Stability
Solutions
Protein Structure, Quaternary
Cyclodextrins
A homologous group of cyclic GLUCANS consisting of alpha-1,4 bound glucose units obtained by the action of cyclodextrin glucanotransferase on starch or similar substrates. The enzyme is produced by certain species of Bacillus. Cyclodextrins form inclusion complexes with a wide variety of substances.
Surface-Active Agents
Fatty Acids, Nonesterified
Phospholipids
Lipids containing one or more phosphate groups, particularly those derived from either glycerol (phosphoglycerides see GLYCEROPHOSPHOLIPIDS) or sphingosine (SPHINGOLIPIDS). They are polar lipids that are of great importance for the structure and function of cell membranes and are the most abundant of membrane lipids, although not stored in large amounts in the system.
Lipid Metabolism
Nanocapsules
Hydrogen Bonding
Anilino Naphthalenesulfonates
Carbon Dioxide
Structure-Activity Relationship
Nucleic Acid Denaturation
Disruption of the secondary structure of nucleic acids by heat, extreme pH or chemical treatment. Double strand DNA is "melted" by dissociation of the non-covalent hydrogen bonds and hydrophobic interactions. Denatured DNA appears to be a single-stranded flexible structure. The effects of denaturation on RNA are similar though less pronounced and largely reversible.
Chitosan
Surface Properties
Peptides
Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.
Emulsions
Colloids formed by the combination of two immiscible liquids such as oil and water. Lipid-in-water emulsions are usually liquid, like milk or lotion. Water-in-lipid emulsions tend to be creams. The formation of emulsions may be aided by amphiphatic molecules that surround one component of the system to form MICELLES.
Polymers
Body Weight
Thermogenesis
Nanoparticles
Tablets
Dimerization
Ultracentrifugation
Pulmonary Gas Exchange
Protein Multimerization
Lipids
A generic term for fats and lipoids, the alcohol-ether-soluble constituents of protoplasm, which are insoluble in water. They comprise the fats, fatty oils, essential oils, waxes, phospholipids, glycolipids, sulfolipids, aminolipids, chromolipids (lipochromes), and fatty acids. (Grant & Hackh's Chemical Dictionary, 5th ed)
Dietary Carbohydrates
Carbohydrates present in food comprising digestible sugars and starches and indigestible cellulose and other dietary fibers. The former are the major source of energy. The sugars are in beet and cane sugar, fruits, honey, sweet corn, corn syrup, milk and milk products, etc.; the starches are in cereal grains, legumes (FABACEAE), tubers, etc. (From Claudio & Lagua, Nutrition and Diet Therapy Dictionary, 3d ed, p32, p277)
Solvents
Deuterium
Guanidine
A strong organic base existing primarily as guanidium ions at physiological pH. It is found in the urine as a normal product of protein metabolism. It is also used in laboratory research as a protein denaturant. (From Martindale, the Extra Pharmacopoeia, 30th ed and Merck Index, 12th ed) It is also used in the treatment of myasthenia and as a fluorescent probe in HPLC.
Cattle
Cations
Methylcellulose
Obesity
A status with BODY WEIGHT that is grossly above the acceptable or desirable weight, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).
Insulin
A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1).
Glucose
Nutritional Requirements
Drug Delivery Systems
Salts
Glycerol
Adipose Tissue
Specialized connective tissue composed of fat cells (ADIPOCYTES). It is the site of stored FATS, usually in the form of TRIGLYCERIDES. In mammals, there are two types of adipose tissue, the WHITE FAT and the BROWN FAT. Their relative distributions vary in different species with most adipose tissue being white.
Dipodomys
Muramidase
A basic enzyme that is present in saliva, tears, egg white, and many animal fluids. It functions as an antibacterial agent. The enzyme catalyzes the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrin. EC 3.2.1.17.
Cholesterol
Glucose Clamp Technique
Physical Exertion
Osmolar Concentration
Amino Acid Motifs
Models, Biological
Mutagenesis, Site-Directed
Nitrogen
Carboxymethylcellulose Sodium
Exercise
DNA
A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).
Catalytic Domain
Tryptophan
An essential amino acid that is necessary for normal growth in infants and for NITROGEN balance in adults. It is a precursor of INDOLE ALKALOIDS in plants. It is a precursor of SEROTONIN (hence its use as an antidepressant and sleep aid). It can be a precursor to NIACIN, albeit inefficiently, in mammals.
Oxygen Isotopes
Framycetin
Starch
Benzoyl Peroxide
Polyethylene Glycols
Polymers of ETHYLENE OXIDE and water, and their ethers. They vary in consistency from liquid to solid depending on the molecular weight indicated by a number following the name. They are used as SURFACTANTS, dispersing agents, solvents, ointment and suppository bases, vehicles, and tablet excipients. Some specific groups are NONOXYNOLS, OCTOXYNOLS, and POLOXAMERS.
Substrate Specificity
Biological Availability
Amino Acid Substitution
The naturally occurring or experimentally induced replacement of one or more AMINO ACIDS in a protein with another. If a functionally equivalent amino acid is substituted, the protein may retain wild-type activity. Substitution may also diminish, enhance, or eliminate protein function. Experimentally induced substitution is often used to study enzyme activities and binding site properties.
Molecular Docking Simulation
Microscopy, Polarization
Apoproteins
Body Fluid Compartments
Buffers
Fatty Acids
Sequence Homology, Amino Acid
Nucleic Acid Conformation
Allosteric Regulation
Measured versus predicted oxygen consumption in children with congenital heart disease. (1/799)
OBJECTIVE: To compare measured and predicted oxygen consumption (VO2) in children with congenital heart disease. DESIGN: Retrospective study. SETTING: The cardiac catheterisation laboratory in a university hospital. PATIENTS: 125 children undergoing preoperative cardiac catheterisation. INTERVENTIONS: VO2 was measured using indirect calorimetry; the predicted values were calculated from regression equations published by Lindahl, Wessel et al, and Lundell et al. Stepwise linear regression and analysis of variance were used to evaluate the influence of age, sex, weight, height, cardiac malformation, and heart failure on the bias and precision of predicted VO2. An artificial neural network was trained and used to produce an estimate of VO2 employing the same variables. The various estimates for VO2 were evaluated by calculating their bias and precision values. RESULTS: Lindahl's equation produced the highest precision (+/- 42%) of the regression based estimates. The corresponding average bias of the predicted VO2 was 3% (range -66% to 43%). When VO2 was predicted according to regression equations by Wessel and Lundell, the bias and precision were 0% and +/- 44%, and -16% and +/- 51%, respectively. The neural network predicted VO2 from variables included in the regression equations with a bias of 6% and precision +/- 29%; addition of further variables failed to improve this estimate. CONCLUSIONS: Both regression based and artificial intelligence based techniques were inaccurate for predicting preoperative VO2 in patients with congenital heart disease. Measurement of VO2 is necessary in the preoperative evaluation of these patients. (+info)Comparison of indirect calorimetry, the Fick method, and prediction equations in estimating the energy requirements of critically ill patients. (2/799)
BACKGROUND: Accurate measurement of resting energy expenditure (REE) is helpful in determining the energy needs of critically ill patients requiring nutritional support. Currently, the most accurate clinical tool used to measure REE is indirect calorimetry, which is expensive, requires trained personnel, and has significant error at higher inspired oxygen concentrations. OBJECTIVE: The purpose of this study was to compare REE measured by indirect calorimetry with REE calculated by using the Fick method and prediction equations by Harris-Benedict, Ireton-Jones, Fusco, and Frankenfield. DESIGN: REEs of 36 patients [12 men and 24 women, mean age 58+/-22 y and mean Acute Physiology and Chronic Health Evaluation II score 22+/-8] in a hospital intensive care unit and receiving mechanical ventilation and total parenteral nutrition (TPN) were measured for > or = 15 min by using indirect calorimetry and compared with REEs calculated from a mean of 2 sets of hemodynamic measurements taken during the metabolic testing period with an oximetric pulmonary artery catheter. RESULTS: Mean REE by indirect calorimetry was 8381+/-1940 kJ/d and correlated poorly with the other methods tested (r = 0.057-0.154). This correlation did not improve after adjusting for changes in respiratory quotient (r2 = 0.28). CONCLUSIONS: These data do not support previous findings showing a strong correlation between REE determined by the Fick method and other prediction equations and indirect calorimetry. In critically ill patients receiving TPN, indirect calorimetry, if available, remains the most appropriate clinical tool for accurate measurement of REE. (+info)Physical activity assessment in American Indian schoolchildren in the Pathways study. (3/799)
The objective of the Pathways physical activity feasibility study was to develop methods for comparing type and amount of activity between intervention and control schools participating in a school-based obesity prevention program. Two methods proved feasible: 1) a specially designed 24-h physical activity recall questionnaire for assessing the frequency and type of activities and 2) use of a triaxial accelerometer for assessing amount of activity. Results from pilot studies supporting the use of these methods are described. Analyses of activity during different segments of the day showed that children were most active after school. The activities reported most frequently (e.g., basketball and mixed walking and running) were also the ones found to be most popular in the study population on the basis of formative assessment surveys. Both the physical activity recall questionnaire and the triaxial accelerometer methods will be used to assess the effects of the full-scale intervention on physical activity. (+info)Energy and substrate metabolism in patients with active Crohn's disease. (4/799)
The aim of the study was to evaluate the possible contribution of changes in energy metabolism and substrate oxidation rates to malnutrition in Crohn's disease and to assess the effect of enteral nutrition on these parameters. Energy metabolism was evaluated by indirect calorimetry in 32 patients with active Crohn's disease and 19 age- and sex-matched healthy individuals. Measurements were done in the postabsorptive state. Seven out of 32 patients received enteral nutrition via a nasogastric tube. In these patients, resting energy metabolism was determined at d 0 (postabsorptive), 7, 14 (during full enteral nutrition) and 15 (postabsorptive). Resting energy expenditure was not significantly different between patients and controls, whereas the respiratory quotient (RQ) was lower in patients (0.78 +/- 0.05 vs. 0.86 +/- 0.05; P < 0.05). During enteral nutrition in 7 patients with Crohn's disease, the RQ increased on d 7 compared with d 0 and remained high even after cessation of enteral nutrition (d 0, 0.78 +/- 0.03; d 7, 0.91 +/- 0.04; d 15, 0. 84 +/- 0.05; P < 0.05; d 7 and 15 vs. d 0). No effects of enteral nutrition on resting energy expenditure were found. Active Crohn's disease is associated with changes in substrate metabolism that resemble a starvation pattern. These changes appear not to be specific to Crohn's disease but to malnutrition and are readily reversed by enteral nutrition. Enteral nutrition did not affect resting energy expenditure. Wasting is a consequence of malnutrition but not of hypermetabolism in Crohn's disease. (+info)Acute effect of ephedrine on 24-h energy balance. (5/799)
Ephedrine is used to help achieve weight control. Data on its true efficacy and mechanisms in altering energy balance in human subjects are limited. We aimed to determine the acute effect of ephedrine on 24-h energy expenditure, mechanical work and urinary catecholamines in a double-blind, randomized, placebo-controlled, two-period crossover study. Ten healthy volunteers were given ephedrine (50 mg) or placebo thrice daily during each of two 24-h periods (ephedrine and placebo) in a whole-room indirect calorimeter, which accurately measures minute-by-minute energy expenditure and mechanical work. Measurements were taken of 24-h energy expenditure, mechanical work, urinary catecholamines and binding of (+/-)ephedrine in vitro to human beta1-, beta2- and beta3-adrenoreceptors. Twenty-four-hour energy expenditure was 3.6% greater (8965+/-1301 versus 8648+/-1347 kJ, P<0.05) with ephedrine than with placebo, but mechanical work was not different between the ephedrine and placebo periods. Noradrenaline excretion was lower with ephedrine (0.032+/-0.011 microg/mg creatinine) compared with placebo (0.044+/-0.012 microg/mg creatinine) (P<0.05). (+/-)Ephedrine is a relatively weak partial agonist of human beta1- and beta2-adrenoreceptors, and had no detectable activity at human beta3-adrenoreceptors. Ephedrine (50 mg thrice daily) modestly increases energy expenditure in normal human subjects. A lack of binding of ephedrine to beta3-adrenoreceptors and the observed decrease in urinary noradrenaline during ephedrine treatment suggest that the thermogenic effect of ephedrine results from direct beta1-/beta2-adrenoreceptor agonism. An indirect beta3-adrenergic effect through the release of noradrenaline seems unlikely as urinary noradrenaline decreased significantly with ephedrine. (+info)Effects of insulin and amino acids on glucose and leucine metabolism in CAPD patients. (6/799)
This study investigates the basal and insulin-stimulated glucose metabolism, substrate utilization, and protein turnover in eight patients maintained on continuous ambulatory peritoneal dialysis (CAPD) (mean age 39+/-5 yr, body mass index [BMI] 108+/-6) and 14 control subjects (mean age 33+/-4 yr, BMI 103+/-3). Euglycemic insulin clamp studies (180 min) were performed in combination with continuous indirect calorimetry and 1-14C leucine infusion (study I). Postabsorptive glucose oxidation was higher (1.75+/-0.18 versus 1.42+/-0.14 mg/kg per min) and lipid oxidation was lower (0.43+/-0.09 versus 0.61+/-0.12 mg/kg per min) in CAPD patients than in control subjects (P<0.05 versus control subjects). During the last 60 min of euglycemic hyperinsulinemia, the total rate of glucose metabolism was similar in CAPD and control subjects (6.33+/-0.51 versus 6.54+/-0.62 mg/kg per min). Both insulin-stimulated glucose oxidation (2.53+/-0.27 versus 2.64+/-0.37 mg/kg per min) and glucose storage (3.70+/-0.48 versus 3.90+/-0.58 mg/kg per min) were similar in CAPD and control subjects. Basal leucine flux (an index of endogenous proteolysis) was significantly lower in CAPD patients than in control subjects (1.21+/-0.15 versus 1.65+/-0.07 micromol/kg per min). Leucine oxidation (0.13+/-0.02 versus 0.26+/-0.02 micromol/kg per min) and nonoxidative leucine disposal (an index of protein synthesis) (1.09+/-0.16 versus 1.35+/-0.05 micromol/kg per min) were also reduced in CAPD compared with control subjects (P<0.01 versus control subjects). In response to insulin (study I), endogenous leucine flux decreased to 0.83+/-0.08 and 1.05+/-0.05 micromol/kg per min in CAPD and control subjects, respectively (all P<0.01 versus basal). Leucine oxidation declined to 0.06+/-0.01 and to 0.19+/-0.02 micromol/kg per min in CAPD and control subjects, respectively (P<0.01 versus basal). A second insulin clamp was performed in combination with an intravenous amino acid infusion (study II). During insulin plus amino acid administration, nonoxidative leucine disposal rose to 1.23+/-0.17 and 1.42+/-0.09 micromol/kg per min in CAPD and control subjects, respectively (both P<0.05 versus basal, P = NS versus control subjects), and leucine balance, an index of the net amino acid flux into protein, become positive in both groups (0.30+/-0.05 versus 0.40+/-0.07 micromol/kg per min in CAPD and control subjects, respectively) (both P<0.01 versus basal, P = NS versus control subjects). In summary, in CAPD patients: (1) basal glucose oxidation is increased; (2) basal lipid oxidation is decreased; (3) insulin-mediated glucose oxidation and storage are normal; (4) basal leucine flux is reduced; (5) the antiproteolitic action of insulin is normal; and (6) the anabolic response to insulin plus amino acid administration is normal. Uremic patients maintained on CAPD treatment show a preferential utilization of glucose as postabsorptive energy substrate; however, their anabolic response to substrate administration and the sensitivity to insulin are normal. (+info)Endogenous thermoregulatory rhythms of squirrel monkeys in thermoneutrality and cold. (7/799)
Whole body heat production (HP) and heat loss (HL) were examined to determine if the free-running circadian rhythm in body temperature (Tb) results from coordinated changes in HP and HL rhythms in thermoneutrality (27 degrees C) as well as mild cold (17 degrees C). Squirrel monkey metabolism (n = 6) was monitored by both indirect and direct calorimetry, with telemetered measurement of Tb and activity. Feeding was also measured. Rhythms of HP, HL, and conductance were tightly coupled with the circadian Tb rhythm at both ambient temperatures (TA). At 17 degrees C, increased HP compensated for higher HL at all phases of the Tb rhythm, resulting in only minor changes to Tb. Parallel compensatory changes of HP and HL were seen at all rhythm phases at both TA. Similar time courses of Tb, HP, and HL in their respective rhythms and the relative stability of Tb during both active and rest periods suggest action of the circadian timing system on Tb set point. (+info)Effect of protein intake and physical activity on 24-h pattern and rate of macronutrient utilization. (8/799)
Effects of moderate physical activity (90 min at 45-50% of maximal O2 uptake 2 times daily) and "high" (2.5 g protein. kg-1. day-1, n = 6) or "normal" protein intake (1.0 g protein. kg-1. day-1, n = 8) on the pattern and rate of 24-h macronutrient utilization in healthy adult men were compared after a diet-exercise-adjustment period of 6 days. Energy turnover (ET) was determined by indirect and direct (suit) calorimetry, and "protein oxidation" was determined by a 24-h continuous intravenous infusion of [1-13C]leucine. Subjects were in slight positive energy balance during both studies. Protein contributed to a higher (22 vs. 10%) and carbohydrate (CHO) a lower (33 vs. 58%) proportion of total 24-h ET on the high- vs. normal-protein intake. The highest contribution of fat to ET was seen postexercise during fasting (73 and 61% of ET for high and normal, respectively). With the high-protein diet the subjects were in a positive protein (P < 0.001) and CHO balance (P < 0.05) and a negative fat balance (P < 0.05). The increased ET postexercise was not explained by increased rates of urea production and/or protein synthesis. (+info)
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Heat Capacity of Calorimeter | Principle | Features | Operation
Choice of the Calorimeter Material
A coffee cup calorimeter contains 100ml of .200M H2SO4 at 22.3 degrees
PPT - Metabolic Calculations - Purpose PowerPoint Presentation - ID:5638666
Basal Metabolic Rate Counter 1.1 - BMR Calculator estimates your Basal Metabolic Rate, the amount of calories your...
How Many Calories Do I Need Each Day?
Progressive alterations in lipid and glucose metabolism during short-term fasting in young adult men
Education - Sable Systems International
Education - Sable Systems International
Basal Metabolic Rate (BMR) Calculator - HealthRuby.com
Calorimetry
How to Calculate BMR (Basal Metabolic Rate) | Get Fit - Jillian Michaels
BMR 1,324 - Basal Metabolic Rate of 1,324 calories per day.
BMR 1,725 - Basal Metabolic Rate of 1,725 calories per day.
Basal Metabolic Rate Calculator - myDr.com.au
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Weir formula
"Indirect Calorimetry" (PDF). "Techniques available for measuring energy expenditure". United Nations University. Weir, J. B. de ... The Weir formula is a formula used in indirect calorimetry, relating metabolic rate to oxygen consumption and carbon dioxide ...
BAZ1B
"Indirect Calorimetry Data for Baz1b". Mouse Resources Portal. sanger.ac.uk. Wellcome Trust Sanger Institute. "Body Composition ... Mutant mice showed increased activity, VO2 and energy expenditure, determined by indirect calorimetry. Radiography found teeth ...
NSUN2
"Indirect calorimetry data for Nsun2". Wellcome Trust Sanger Institute. "Glucose tolerance test data for Nsun2". Wellcome Trust ... and abnormal indirect calorimetry and plasma chemistry parameters. Males (but not females) were also infertile. In addition, ...
AKAP9
"Indirect calorimetry data for Akap9". Wellcome Trust Sanger Institute. "Glucose tolerance test data for Akap9". Wellcome Trust ...
RAD18
"Indirect calorimetry data for Rad18". Wellcome Trust Sanger Institute. "DEXA data for Rad18". Wellcome Trust Sanger Institute ... Mutant male mice showed increased activity, VO2 and energy expenditure, determined by indirect calorimetry. Dual-energy X-ray ...
DNASE1L2
"Indirect calorimetry data for Dnase1l2". Wellcome Trust Sanger Institute. "DEXA data for Dnase1l2". Wellcome Trust Sanger ... abnormal indirect calorimetry and femur/tibia morphology. Females also had an increased blood urea nitrogen level while males ...
WDR47
"Indirect calorimetry data for Wdr47". Wellcome Trust Sanger Institute. "Clinical chemistry data for Wdr47". Wellcome Trust ... Male homozygous mice also had abnormal indirect calorimetry measures. WD repeat GRCh38: Ensembl release 89: ENSG00000085433 - ...
DLG4
"Indirect calorimetry data for Dlg4". Wellcome Trust Sanger Institute. "DEXA data for Dlg4". Wellcome Trust Sanger Institute. " ... Homozygous mutant animals had decreased body weight, atypical indirect calorimetry and DEXA data and a skin phenotype. Males ... Its direct and indirect binding partners include neuroligin, NMDA receptors, AMPA receptors, and potassium channels. It plays ... Eldstrom J, Choi WS, Steele DF, Fedida D (July 2003). "SAP97 increases Kv1.5 currents through an indirect N-terminal mechanism ...
GRXCR1
"Indirect calorimetry data for Grxcr1". Wellcome Trust Sanger Institute. "Glucose tolerance test data for Grxcr1". Wellcome ... Male homozygous mutant animals additionally showed abnormal indirect calorimetry and clinical chemistry parameters, improved ...
Putative sodium-coupled neutral amino acid transporter 10
"Indirect calorimetry data for Slc38a10". Wellcome Trust Sanger Institute. "DEXA data for Slc38a10". Wellcome Trust Sanger ... Indirect calorimetry analysis showed that males displayed increased oxygen consumption and energy expenditure, while clinical ...
ZC3HC1
"Indirect calorimetry data for Zc3hc1". Wellcome Trust Sanger Institute. "DEXA data for Zc3hc1". Wellcome Trust Sanger Institute ... Males also had a decreased body weight, an abnormal posture and atypical indirect calorimetry data. Females also had an ...
Mitochondrial 2-oxodicarboxylate carrier
"Indirect calorimetry data for Slc25a21". Wellcome Trust Sanger Institute. "DEXA data for Slc25a21". Wellcome Trust Sanger ... atypical indirect calorimetry, body composition and plasma chemistry data, increased mean platelet volume and moderate ...
RNF10
"Indirect calorimetry data for Rnf10". Wellcome Trust Sanger Institute. "DEXA data for Rnf10". Wellcome Trust Sanger Institute ...
Slc22a21
"Indirect calorimetry data for Slc22a21". Wellcome Trust Sanger Institute. "Salmonella infection data for Slc22a21". Wellcome ...
CENPJ
"Indirect calorimetry data for Cenpj". Wellcome Trust Sanger Institute. "Glucose tolerance test data for Cenpj". Wellcome Trust ... peripheral blood lymphocytes and indirect calorimetry parameters, abnormal head, genitalia and tail morphology, an impaired ...
MYO7A
"Indirect calorimetry data for Myo7a". Wellcome Trust Sanger Institute. "Glucose tolerance test data for Myo7a". Wellcome Trust ... severe hearing impairment and a number of abnormal indirect calorimetry and clinical chemistry parameters. GRCh38: Ensembl ...
DLG2
"Indirect calorimetry data for Dlg2". Wellcome Trust Sanger Institute. "DEXA data for Dlg2". Wellcome Trust Sanger Institute. " ... Both sexes had atypical indirect calorimetry and DEXA parameters. Females also had decreased body weight, decreased circulating ...
CBX1
"Entrez Gene: CBX1 chromobox homolog 1 (HP1 beta homolog Drosophila )". "Indirect calorimetry data for Cbx1". Wellcome Trust ... and energy expenditure as determined by indirect calorimetry. CBX1 has been shown to interact with: C11orf30, CBX3 and CBX5, ...
Microcephalin
Indirect calorimetry. Normal Glucose tolerance test. Normal Auditory brainstem response. Abnormal DEXA. Normal ...
Protein arginine methyltransferase 5
Indirect calorimetry. Normal Glucose tolerance test. Normal Auditory brainstem response. Normal DEXA. Normal ...
MYH9
Indirect calorimetry. Normal Glucose tolerance test. Normal Auditory brainstem response. Normal DEXA. Normal ...
Polynucleotide phosphorylase
Indirect calorimetry. Normal Glucose tolerance test. Normal Auditory brainstem response. Normal DEXA. Normal ...
Gap-43 protein
Indirect calorimetry. Normal. Glucose tolerance test. Normal. Auditory brainstem response. Normal. DEXA. Normal. ...
Resting metabolic rate
Indirect calorimetry is considered the gold-standard method to measure RMR. Indirect calorimeters are usually found in ... Indirect calorimetry is the study or clinical use of the relationship between respirometry and bioenergetics, where the ... Thus, estimation of REE by indirect calorimetry is strongly recommended for accomplishing long-term weight management, a ... "Indirect calorimetry: a practical guide for clinicians". Nutrition in Clinical Practice. 22 (4): 377-388. doi:10.1177/ ...
Weight management
BMR can be measured via direct and indirect calorimetry; however, it is possible to estimate a person's BMR using one of ... Jeor Equation was found to be the most accurate predictor of BMR compared to BMR measured by direct and indirect calorimetry. ...
FAM134C
Females had increased indirect calorimetry parameters while males had an increased susceptibility to bacterial infection. ... CS1 maint: discouraged parameter (link) "Indirect calorimetry data for Fam134c". Wellcome Trust Sanger Institute. "Eye ...
Respiratory quotient
Such measurements, like measurements of oxygen uptake, are forms of indirect calorimetry. It is measured using a respirometer. ... "Clinical use of the respiratory quotient obtained from indirect calorimetry". Journal of Parenteral and Enteral Nutrition. 27 ( ...
Basal metabolic rate
BMR may be measured by gas analysis through either direct or indirect calorimetry, though a rough estimation can be acquired ... This can be confirmed by blood tests and gas analysis using either direct or indirect calorimetry to show the effect of ... along with the oxygen and carbon dioxide measures taken from calorimetry. Studies also showed that by eliminating the sex ...
Excess post-exercise oxygen consumption
"Direct and indirect calorimetry of lactate oxidation: Implications for whole-body energy expenditure". Journal of Sports ... direct and indirect calorimeter experiments have definitively disproven any association of lactate metabolism as causal to an ...
Parathyroid hormone
Indirect calorimetry. Normal Glucose tolerance test. Normal Auditory brainstem response. Normal DEXA. Normal ... Stimulation is indirect since osteoclasts do not have a receptor for PTH; rather, PTH binds to osteoblasts, the cells ...
Heat
The Carathéodory way regards calorimetry only as a secondary or indirect way of measuring quantity of energy transferred as ... In calorimetry, sensible heat is defined with respect to a specific chosen state variable of the system, such as pressure or ... Calorimetry is the empirical basis of the idea of quantity of heat transferred in a process. The transferred heat is measured ... They include calorimetry, which is the commonest practical way of finding internal energy differences.[74] The needed ...
Kleiber's law
... and indirect (oxygen consumption) calorimetry. Typical values for f are 15-20%.[15] ...
Mass spectrometry
... term mass spectroscope continued to be used even though the direct illumination of a phosphor screen was replaced by indirect ... Calorimetry. *Chromatography. *Electroanalytical methods. *Gravimetric analysis. *Ion-mobility spectrometry. *Mass spectrometry ...
Gravimetric analysis
Nevertheless, the indirect method, although less reliable than direct, is still widely used in commerce. For example, it's used ... Determination of the amount of water by measuring the loss in mass of the sample during heating is an example of an indirect ... Volatilization methods can be either direct or indirect. Water eliminated in a quantitative manner from many inorganic ...
ATLAS experiment
These measurements will provide indirect information on the details of the Standard Model, with the possibility of revealing ... "Calorimetry". ATLAS Technical Proposal. CERN. 1994.. *^ a b "Magnet system". ATLAS Technical Proposal. CERN. 1994.. ...
Protein
For example, indirect immunofluorescence will allow for fluorescence colocalization and demonstration of location. Fluorescent ... Isothermal titration calorimetry. *X-ray crystallography. *Protein NMR. *Cryo-electron microscopy. *Freeze-fracture electron ...
پروتئین - ویکی‌پدیا، دانشنامهٔ آزاد
For example, indirect immunofluorescence will allow for fluorescence colocalization and demonstration of location. Fluorescent ... Isothermal titration calorimetry. *X-ray crystallography. *Protein NMR. *Cryo-electron microscopy. *Freeze-fracture electron ...
Immunoprecipitation
Indirect[edit]. Antibodies that are specific for a particular protein, or a group of proteins, are added directly to the ... Isothermal titration calorimetry. *X-ray crystallography. *Protein NMR. *Cryo-electron microscopy. *Freeze-fracture electron ... The indirect method is also used when the binding kinetics of the antibody to the protein is slow for a variety of reasons. In ... An indirect approach is sometimes preferred when the concentration of the protein target is low or when the specific affinity ...
Luteal phase
This group was measured via simultaneously direct and indirect calorimetry and had standardized daily meals and sedentary ... Whole body calorimetry studies in the menstrual cycle. New York: Fourth International Conference on Obesity 1983;52(abstr). ...
Immunohistochemistry
The indirect method involves an unlabeled primary antibody (first layer) that binds to the target antigen in the tissue and a ... Isothermal titration calorimetry. *X-ray crystallography. *Protein NMR. *Cryo-electron microscopy. *Freeze-fracture electron ... The indirect method of immunohistochemical staining uses one antibody against the antigen being probed for, and a second, ... The indirect method, aside from its greater sensitivity, also has the advantage that only a relatively small number of standard ...
Glossary of firefighting
Indirect attack: Method of firefighting in which water is pumped onto materials above or near the fire so that the splash rains ... verified Thornton's Rule using the oxygen consumption calorimetry technique, developed at NIST in the early 1970s. In " ... Backfiring: Also known as a "controlled burn," it's a tactic mostly used in wildland firefighting associated with indirect ... These included 3D offensive water-fog; smooth-bore/straight stream (direct) attack; indirect attack; tactical ventilation ...
Dynamic reserve
If reserves are omitted, there is not enough flexibility to capture product formation and explain indirect calorimetry. ... This organizational position of reserve creates a rather constant internal chemical environment, with only an indirect coupling ...
Ligand (biochemistry)
... isothermal titration calorimetry or surface plasmon resonance. Low-affinity binding (high Ki level) implies that a relatively ... Coimmunopreciptation indirect ELISA, equilibrium dialysis, gel electrophoresis, far western blot, fluorescence polarization ...
Respiratory exchange ratio
Ratio of carbon dioxide produced by the body to oxygen consumed by the body Indirect calorimetry Fick principle - Principle ...
Measuring instrument
Redox electrode Other values may be determined indirectly by calorimetry. Also by analyzing phase-diagrams. See also the ... using the Doppler effect for indirect measurement of velocity. LIDAR speed gun Speedometer Tachometer (speed of rotation) ... calorimetry) or the transferred energy of the non-thermal carrier may be measured. calorimeter (any device for measuring the ... or coffee cup calorimeter Differential Scanning Calorimeter Reaction calorimeter see also Calorimeter or Calorimetry Entropy is ...
Protein-protein interaction
Doubly indirect interactions, mediated by two water molecules, are more numerous in the homologous complexes of low affinity. ... and calorimetry. The experimental detection and characterization of PPIs is labor-intensive and time-consuming. However, many ... Lisova O, Belkadi L, Bedouelle H (April 2014). "Direct and indirect interactions in the recognition between a cross- ...
Tests of relativistic energy and momentum
But those tests demonstrate the relativistic expressions in an indirect way, since many other effects have to be considered in ... Therefore, the heat produced by some electrons hitting the aluminium disc was measured by calorimetry in order to directly ... "Calorimetry for particle physics" (PDF). Reviews of Modern Physics. 75 (4): 1243-1286. Bibcode:2003RvMP...75.1243F. doi:10.1103 ...
List of ASTM International standards (D6001-7000)
Indirect Preparation, and Analysis for Asbestos Structure Number Surface Loading by Transmission Electron Microscopy D6481 - 14 ... 19 Test Method for Oxidation Induction Time of Lubricating Oils by Pressure Differential Scanning Calorimetry (PDSC) D6188 - 17 ... 17 Test Method for Indirect Tensile (IDT) Strength of Asphalt Mixtures D6932/D6932M - 08(2013) Guide for Materials and ... Practice for Glass Transition Temperatures of Hydrocarbon Resins by Differential Scanning Calorimetry D6605 - 06(2020) Practice ...
Pozzolanic activity
Indirect methods comprise on the one hand methods that investigate which material properties are responsible for the pozzolan's ... Measurements of the electrical conductivity, chemical shrinkage of the pastes or the heat evolution by heat flow calorimetry ...
Indirect Calorimetry
Indirect calorimetry - WUR
Indirect calorimetry. Energy metabolism is measured by means of indirect calorimetry. Indirect calorimetry is a method where ... Indirect calorimetry is combined with an on line technique to measure 13CO2 enrichment. The 13C enriched substrates can be used ... The indirect calorimetry studies are performed at the the Climate Respiration Unit of the Department of Animal Sciences within ... Furthermore, within the calorimetry facilities, in individually as well as in group-housing settings, we use a radar-Doppler ...
Indirect calorimetry - Wikipedia
Respiratory indirect calorimetry, or indirect calorimetry (IC) as it is known by most authors, is a noninvasive and highly ... "Measuring RMR with Indirect Calorimetry (IC)." Nutr Clin Pract. 2007 Aug;22(4):377-88. "Measuring RMR with Indirect Calorimetry ... Indirect calorimetry, as we know it, was developed at the turn of the centurys as an application of thermodynamics to animal ... Indirect calorimetry is the method by which the type and rate of substrate utilization, and energy metabolism are estimated in ...
Indirect Calorimetry. ClÃnica Universidad de Navarra
The indirect calorimetry is a diagnostic test that allows to know in an individualized way the energetic expense of each ... The indirect calorimetry determines the energetic expense in rest of a person, that is to say, it is going to inform to us on ... Indirect calorimetry. If there is excess fat, the patient may have a cardiometabolic risk profile, which carries a high risk ... In addition, indirect calorimetry measures the nutritional needs of each person.. The energy expenditure produces an exchange ...
Agreement between indirect calorimetry and traditional tests of lactose malabsorption - Archive ouverte HAL
Indirect calorimetry could improve the reliability of lactose malabsorption diagnosis. Studies on larger populations are needed ... Agreement between indirect calorimetry and traditional tests of lactose malabsorption Virginie Alexandre Anne-Marie Davila 1 ... Agreement between indirect calorimetry and traditional tests of lactose malabsorption. Digestive and Liver Disease, WB Saunders ... Indirect calorimetry could improve the reliability of lactose malabsorption diagnosis. Studies on larger populations are needed ...
Agreement between indirect calorimetry and traditional tests of lactose malabsorption - IDF
Simultaneous Direct and Indirect Calorimetry on Normoxic and Anoxic Goldfish | Journal of Experimental Biology
Simultaneous Direct and Indirect Calorimetry on Normoxic and Anoxic Goldfish. J. VAN WAVERSVELD, A. D. F. ADDINK, G. VAN DEN ... Simultaneous Direct and Indirect Calorimetry on Normoxic and Anoxic Goldfish. J. VAN WAVERSVELD, A. D. F. ADDINK, G. VAN DEN ... Simultaneous Direct and Indirect Calorimetry on Normoxic and Anoxic Goldfish. J. VAN WAVERSVELD, A. D. F. ADDINK, G. VAN DEN ... Simultaneous Direct and Indirect Calorimetry on Normoxic and Anoxic Goldfish Message Subject (Your Name) has sent you a message ...
Baxter and COSMED Announce U.S. FDA 510(k) Clearance of Q-NRG+ Indirect Calorimetry Device | Baxter
Baxter and COSMED Announce U.S. FDA 510(k) Clearance of Q-NRG+ Indirect Calorimetry Device ... COSMED products include a full range of spirometers, indirect calorimetry, cardio pulmonary exercise testing and body ... Predictive equations versus measured energy expenditure by indirect calorimetry: A retrospective validation. Clinical Nutrition ... a metabolic monitoring device utilizing indirect calorimetry (IC) technology. IC is considered the "gold standard"1 to ...
Energy Balance in Critically Ill Children With Severe Sepsis Using Indirect Calorimetry: A Prospective Cohort Study.
Data on energy balance in children with severe sepsis using indirect calorimetry (IC) is lacki... ... sepsis using indirect calorimetry (IC) is lacking. Thus, we planned to study the energy needs and balance of this cohort. ... Sepsis Using Indirect Calorimetry: A Prospective Cohort Study.". Energy needs in critically ill children are dynamic and ... Energy Balance in Critically Ill Children With Severe Sepsis Using Indirect Calorimetry: A Prospective Cohort Study.. 07:00 EST ...
Clinical Applications of Indirect Calorimetry in the Intensive Care Setting | Springer for Research & Development
McClave SA, Snider HL (1992) Use of indirect calorimetry in clinical nutrition. Nutr Clin Pract 7: 207-221PubMedCrossRefGoogle ... McClave SA, Snider HL, Greene L, et al (1992) Effective utilization of indirect calorimetry during critical care. Nut Pract 9: ... Singer P., Cohen J.D. (2003) Clinical Applications of Indirect Calorimetry in the Intensive Care Setting. In: Vincent JL. (eds ... Flancbaum L, Choban PS, Sambucco S, Verducci J, Burge JC (1999) Comparison of indirect calorimetry, the Fick method, and ...
The Effect of Insulin on the Disposal of Intravenous Glucose: Results from Indirect Calorimetry and Hepatic and Femoral Venous...
The Effect of Insulin on the Disposal of Intravenous Glucose: Results from Indirect Calorimetry and Hepatic and Femoral Venous ... The Effect of Insulin on the Disposal of Intravenous Glucose: Results from Indirect Calorimetry and Hepatic and Femoral Venous ... The Effect of Insulin on the Disposal of Intravenous Glucose: Results from Indirect Calorimetry and Hepatic and Femoral Venous ... The Effect of Insulin on the Disposal of Intravenous Glucose: Results from Indirect Calorimetry and Hepatic and Femoral Venous ...
Room Indirect Calorimetry Operating and Reporting Standards (RICORS 1.0): A Guide to Conducting and Reporting Human Whole-Room...
Room Indirect Calorimetry Operating and Reporting Standards (RICORS 1.0): A Guide to Conducting and Reporting Human Whole-Room ... Room Indirect Calorimetry Operating and Reporting Standards (RICORS 1.0): A Guide to Conducting and Reporting Human Whole-Room ... Home > Library > Reporting guideline > Room Indirect Calorimetry Operating and Reporting Standards (RICORS 1.0): A Guide to ...
BIOACTIVE COMPONENTS FROM BLACKBERRIES TO AUGMENT DIETARY APPROACHES TO OBESITY TREATMENT OR PREVENTION: INDIRECT CALORIMETRY...
Substrate utilization and energy expenditure pattern in sepsis by indirect calorimetry | Critical Care | Full Text
Substrate utilization and energy expenditure pattern in sepsis by indirect calorimetry. *Andrew Li. ORCID: orcid.org/0000-0003- ... Li, A., Mukhopadhyay, A. Substrate utilization and energy expenditure pattern in sepsis by indirect calorimetry. Crit Care 24, ... longitudinal data using indirect calorimetry (IC) remain sparse. We aimed to determine the temporal trends of energy ... Lim Hong Hong for her invaluable logistic support and the ICU nurses for obtaining the readings of the indirect calorimetry. ...
Development and validation of GT3X accelerometer cut-off points in 5-9-year-old children based on indirect calorimetry...
Resting Energy Expenditure Measured by Indirect Calorimetry in Obese Patients: Variation Within Different BMI Ranges. | JPEN J...
The adequate provision of energy for obese patients by estimation without indirect calorimetry (IC) is challenging. The goal ... Resting Energy Expenditure Measured by Indirect Calorimetry in Obese Patients: Variation Within Different BMI Ranges. ... Resting Energy Expenditure Measured by Indirect Calorimetry in Obese Patients: Variation W ...
Recommendations for improved data processing from expired gas analysis indirect calorimetry - DRO
Recommendations for improved data processing from expired gas analysis indirect calorimetry Author(s) Robergs, Robert A.. Dwyer ... Recommendations for improved data processing from expired gas analysis indirect calorimetry. Robergs, Robert A., Dwyer, Dan and ... There is currently no universally recommended and accepted method of data processing within the science of indirect calorimetry ... Breath-by-breath datasets obtained from indirect calorimetry during incremental exercise were then used to demonstrate the ...
COSMED - Quark RMR (Indirect Calorimetry Cart)
Stimulation of soluble guanylyl cyclase protects against obesity by recruiting brown adipose tissue | Nature Communications
A paternal methyl donor-rich diet altered cognitive and neural functions in offspring mice | Molecular Psychiatry
Indirect calorimetry. Metabolic assessments were performed at room temperature (23 °C) with a 12:12 h light/dark cycle in the ... 3). Indirect calorimetry revealed reduced variability of RER in MD F1 mice, suggesting a bias toward lipid oxidation in these ... Indirect calorimetry showed reduced maximal RER values in MD F1 offspring, indicating a potential bias toward lipid oxidation46 ...
Effect of Sepsis Syndrome on Neonatal Oxygen Consumption and Energy Expenditure | ELECTRONIC ARTICLE | Pediatrics
... and 2 hours after indirect calorimetry. Measurements of indirect calorimetry were done in a temperature-controlled incubator ( ... Indirect Calorimetry. Measurements of Vo2 and Vco2 were performed by means of a portable open-circuit continuous indirect ... Because Vo2 and Vco2 are influenced strongly by feeding, each period of indirect calorimetry began 45 minutes after feeding20 ... The use of indirect calorimetry in critically ill patients-the relationship of measured energy expenditure to injury severity ...
Reversal of muscle insulin resistance by weight reduction in young, lean, insulin-resistant offspring of parents with type 2...
Measurement Issues Related to Studies of Childhood Obesity: Assessment of Body Composition, Body Fat Distribution, Physical...
Indirect Calorimetry. Indirect calorimetry can be performed easily in children by using standard commercial equipment as ... Energy expenditure is typically measured in humans by either direct or indirect calorimetry. Direct calorimetry involves ... Indirect calorimetry has the added advantage that the ratio of carbon dioxide production to oxygen consumption (the respiratory ... Indirect calorimetry measures energy production by respiratory gas analysis. This approach is based on measurement of oxygen ...
Endogenous circadian system and circadian misalignment impact glucose tolerance via separate mechanisms in humans | PNAS
Parallel assessment of nutrition and activity in athletes: validation against doubly labelled water, 24-h urea excretion, and...
Research Publications - Omnical Indirect Calorimetry
Today Maastricht Instruments is a leading company in providing customers all over the world with novel indirect calorimetry ... Kaviani, S., et al., Determining the Accuracy and Reliability of Indirect Calorimeters Utilizing the Methanol Combustion ... Considerations for the use of Indirect Calorimeters in Nutrition Management. 21 November 2017 ... Considerations for the use of Indirect Calorimeters in Exercise Bioenergetics. 27 November 2017 ...
Comparison of Insulin Aspart and Lispro | Diabetes Care
Effects of Low-Dose Prednisolone on Hepatic and Peripheral Insulin Sensitivity, Insulin Secretion, and Abdominal Adiposity in...
Substrate metabolism, hormone and cytokine levels and adipose tissue signalling in individuals with type 1 diabetes after...
Indirect calorimetry. Indirect calorimetry (Deltatrac monitor; Dantes Instrumentarium, Helsinki, Finland) was used from t = 210 ... We observed a robust increase in NOGD measured by indirect calorimetry during insulin withdrawal. This could relate to ... OGD was estimated by indirect calorimetry and NOGD was calculated by subtracting OGD from Rdgluc [20]. ... Ferrannini E (1988) The theoretical bases of indirect calorimetry: a review. Metabolism 37(3):287-301. https://doi.org/10.1016/ ...
Indirect gas calorimetry module CaloSys - Animalab
Indirect gas calorimetry module CaloSys. Indirect gas calorimetry uses measurements of the animals oxygen consumption (VO2) ... Home / In vivo research / Metabolism and calorimetry / Indirect gas calorimetry module CaloSys ... The PhenoMaster module for indirect gas calorimetry (CaloSys) is a fully automated high-throughput system for short- and long- ... exercise calorimetry on the CaloTreadmill or the CaloWheel. * calorimetry under thermoneutral or rapid temperature challenge ...
Means of indirect calorimetryPredictive equationsEquationsGlucoseExpenditure MeasuredMeasurementCalorimeterHarris-BenedictMetabolic rateOxidationMeasurementsMetabolismOxygenResting Energy ExpenditureUnderwentUreaDeterminationsHumansMethodsNutritionalBreath by breathObeseUtilizationCalibrationClinicalCalorimetricCalorimetersIntensiveConclusionsSubstratesPatientsGold standardExerciseAssessmentRequirementsTestProductionBodyStressStudiesMeasure
Means of indirect calorimetry2
- Energy metabolism is measured by means of indirect calorimetry. (wur.nl)
- Measurements of V o 2 and carbon dioxide production were performed daily for 7 days by means of indirect calorimetry. (aappublications.org)
Predictive equations8
- Flancbaum L, Choban PS, Sambucco S, Verducci J, Burge JC (1999) Comparison of indirect calorimetry, the Fick method, and predictive equations in estimating the energy requirements of critically ill patients. (springer.com)
- We measured REE by indirect calorimetry strictly following the standard procedures, and we compared it to 45 predictive equations. (mdpi.com)
- The study aimed to evaluate the resting energy expenditure (REE) of postpartum women by indirect calorimetry (IC) and provide the most appropriate predictive equations to estimate it. (cosmed.com)
- Background: In the absence of reliable predictive equations, indirect calorimetry (IC) remains the gold standard for assessing energy requirements after spinal cord injury (SCI), but it is typically confined to a research setting. (edu.au)
- Grade: C) Energy requirements may be calculated by predictive equations or measured by indirect calorimetry. (nap.edu)
- Predictive equations should be used with caution, because they provide a less accurate measure of energy requirements than indirect calorimetry in the individual patient. (nap.edu)
- In the obese patient, the predictive equations are even more problematic without availability of indirect calorimetry. (nap.edu)
- Indirect calorimetry is the standard for determination of resting metabolic rate (RMR) in critically ill patients because RMR based on measurement is more accurate than estimation using predictive equations. (nap.edu)
Equations4
- REE of 79 women in a maternity unit of a Brazilian city hospital was measured by Indirect Calorimetry and predicted using eight equations. (cosmed.com)
- Indirect calorimetry, where feasible, and cautious use of estimating equations and increased surveillance for unintended caloric underfeeding and overfeeding are recommended. (nih.gov)
- To investigate agreement between indirect calorimetry and several REE estimating equations in 38 ESRD patients on peritoneal dialysis , we performed indirect calorimetry and compared the results with REEs estimated using 5 equations [Harris-Benedict (HBE), Mifflin, WHO , Schofield, and Cunningham]. (bvsalud.org)
- In ESRD patients on continuous ambulatory peritoneal dialysis ( CAPD ), REE-estimating equations have no significant differences from indirect calorimetry , except Mifflin. (bvsalud.org)
Glucose2
- To determine the relative contributions of glucose oxidation versus glucose storage by peripheral tissues following hyperinsulinemia, we performed euglycemic insulin clamp studies in combination with indirect calorimetry. (diabetesjournals.org)
- Continuous glucose monitoring provided incremental area under the curve (iAUC) and mean amplitude of glycaemic excursion (MAGE) and 10 h indirect calorimetry (whole body calorimeter) (day 2) provided energy expenditure and substrate oxidation. (mdpi.com)
Expenditure Measured2
- Resting Energy Expenditure Measured by Indirect Calorimetry in Obese Patients: Variation Within Different BMI Ranges. (bvsalud.org)
- Methods for data analysis of resting energy expenditure measured using indirect calorimetry. (bioportfolio.com)
Measurement4
- Brandi LS, Grana M, Mazzanti T, Giunta F, Natali A, Ferrannini E (1992) Energy expenditure and gas exchange measurement in postoperative patients: thermodilution vs indirect caloriemtry. (springer.com)
- Furthermore, indirect calorimetry is sensitive to measurement errors, making routine quality control procedures essential. (gehealthcare.com)
- These findings have previously been validated with the use of indirect calorimetry (IDC), 12,13 the standard for the measurement of energy expenditure in the clinical setting. (ahajournals.org)
- Measurement of requirements (indirect calorimetry, 24-hour urinary urea) leading to patient-specific, individualised and goal-directed nutritional therapy. (clinicaltrials.gov)
Calorimeter3
- In order to assess changes in the respiratory quotient, energy expenditure, and calculated substrate oxidation, the subjects completed a 24 hour stay in a room-size indirect calorimeter at the end of each diet period. (umd.edu)
- To make metabolic research studies more attainable, our Omnical Indirect Room Calorimeter uses innovative technology to create a complete system that can be installed in a matter of hours and is then immediately ready to undertake research. (simultech.com.au)
- The white label is on the inside of the indirect calorimeter. (metabolicratetest.com)
Harris-Benedict4
- Coss-Bu JA, Jefferson LS, Walding D, David Y, Smith EO, Klish WJ (1998) Resting energy expenditure in children in a pediatric intensive care unit: comparison of Harris-Benedict andTalbot predictions with indirect calorimetry values. (springer.com)
- We compared nonprotein caloric requirements calculated by Harris-Benedict equation and measured by indirect calorimetry in patients with pancreatic abscess. (elsevier.com)
- Harris-Benedict calculations with stress factor 1.7 differed from indirect calorimetry by at least 15% in seven of ten determinations. (elsevier.com)
- Energy requirements via indirect calorimetry of some patients with pancreatic abscess cover a wide range and do not correlate with Harris-Benedict calculations. (elsevier.com)
Metabolic rate2
- The Weir formula is a formula used in indirect calorimetry, relating metabolic rate to oxygen consumption and carbon dioxide production. (wikipedia.org)
- Metabolic rate was determined by indirect calorimetry. (hindawi.com)
Oxidation2
- It is based on the indirect measure of the heat produced by oxidation of macronutrients, which is estimated by monitoring oxygen consumption (O2) and carbon dioxide production (CO2) for a certain period of time. (wikipedia.org)
- By simultaneous calorimetry the amounts of oxidized substrates during normoxia and anoxia and the amount of excreted ethanol, the end product of incomplete anaerobic oxidation, as well as normoxic and anoxic carbon dioxide production were determined. (biologists.org)
Measurements7
- Indirect calorimetry is a method where heat production and the type and rate of substrate utilization are estimated in vivo starting from gas (O2, CO2 and CH4) exchange measurements. (wur.nl)
- Indirect calorimetry is the method by which the type and rate of substrate utilization, and energy metabolism are estimated in vivo starting from gas exchange measurements (carbon dioxide production and oxygen consumption during rest and steady-state exercise). (wikipedia.org)
- Bursztein S, Saphar P, Singer P, Elwyn DH (1989) A mathematical analysis of indirect calorimetry measurements in acutely ill patients. (springer.com)
- Activity classification into the light-, moderate- or vigorous-intensity category was based on energy expenditure measurements with indirect calorimetry. (theactigraph.com)
- Indirect gas calorimetry uses measurements of the animal's oxygen consumption (VO2) and carbon dioxide production (VCO2) to estimate various metabolic parameters, including the respiratory exchange rate (RQ), energy expenditure (EE), substrate utilization (fat reserves vs. carbohydrate catabolism), and more. (animalab.eu)
- Modular indirect calorimetric devices are easy to use and can facilitates routine clinical measurements. (gehealthcare.com)
- Effects of wearing a FFP2 mask on indirect calorimetry measurements: A pilot study. (bvsalud.org)
Metabolism3
- The indirect calorimetry determines the energetic expense in rest of a person, that is to say, it is going to inform to us on the calories that its organism spends in a situation of rest and, therefore, it will orient to us on its metabolism basal to determine if this one is normal or it is increased or diminished. (cun.es)
- Simultaneous direct and indirect calorimetry together with biochemical determinations of metabolite concentrations were used to compare the normoxic and anoxic energy metabolism of goldfish at 20°C. The normoxic and anoxic heat production levels determined by direct calorimetry were in agreement with previous results: 700 and 200Jh −1 MW −1 , respectively (where MW is metabolic weight, kg 0.85 ). (biologists.org)
- Room indirect calorimetry is used for evaluation of 24-h energy metabolism. (uab.edu)
Oxygen5
- Indirect calorimetry calculates heat that living organisms produce by measuring either their production of carbon dioxide and nitrogen waste (frequently ammonia in aquatic organisms, or urea in terrestrial ones), or from their consumption of oxygen. (wikipedia.org)
- Calorimetry is therefore a spirometry in which the consumption of oxygen and the production of carbon dioxide are measured sequentially. (cun.es)
- Exercise physiologists were first surveyed to determine methods used to process oxygen consumption ([OV0312]O 2) data, and current attitudes to data processing within the science of indirect calorimetry. (edu.au)
- Indirect calorimetry devices for intensive care patients usually apply the open circuit technique, where the flow of gas is measured, and the inspiratory and expiratory concentrations of oxygen and carbon dioxide analyzed. (gehealthcare.com)
- Methods- A simple 4-point Bedside Shivering Assessment Scale was validated against continuous assessments of resting energy expenditure, oxygen consumption, and carbon dioxide production as measured by indirect calorimetry. (ahajournals.org)
Resting Energy Expenditure2
- We aimed to investigate the reliability of resting energy expenditure (REE) measured by indirect calorimetry (IC) with REE calculated using pred. (bioportfolio.com)
- The aim of this study was to test the accuracy of different methods of resting energy expenditure (REE) data analysis using indirect calorimetry (IC) during traditional (30 min) and abbreviated (10 mi. (bioportfolio.com)
Underwent2
- Results- Fifty consecutive cerebrovascular patients underwent indirect calorimetry between January 2006 and June 2007. (ahajournals.org)
- MATERIALS 10 subjects with a mean (SD) age of 43 (10) years and a body mass index of 25.2 (5.8) kg/m2 underwent indirect calorimetry both with and without a class 2 filtering facepiece mask (FFP2), in random order. (bvsalud.org)
Urea1
- Parallel assessment of nutrition and activity in athletes: validation against doubly labelled water, 24-h urea excretion, and indirect calorimetry. (semanticscholar.org)
Determinations2
- Determinations from indirect calorimetry ranged from 22.4-46.8 (mean 36.1) kcal/kg/d. (elsevier.com)
- Stress factor 1.9 results overestimated indirect calorimetry by over 25% in four of ten determinations. (elsevier.com)
Humans1
- The process of measuring heat produced by the and fat are being used to support energy expendi- body during combustion of substances or nutrients ture, this difference in RER makes it possible to in animals or humans is called calorimetry. (yudu.com)
Methods1
- The lack of direct methods has led to development of various models and indirect methods for estimation of fat and fat-free mass, all of which are imperfect and require a number of assumptions, many of which require age-specific considerations, because the usual assumptions in multicompartmental models (eg, hydration of fat-free mass, density of fat-free mass) are known to be influenced by age and state of maturation. (aappublications.org)
Nutritional2
- In addition, indirect calorimetry measures the nutritional needs of each person. (cun.es)
- During the coronavirus disease 2019 (COVID-19) pandemic the use of Indirect calorimetry (IC) during nutritional rehabilitation program requires special precautions due to possible contagions for patients and health professionals. (bvsalud.org)
Breath by breath3
- Face mask (breath by breath): Indirect calorimetry tests are also often performed with a face mask, which is used to convey exhaled and inhaled gas through a turbine flowmeter able to measure the patient's breath by breath minute ventilation, at the same time a sample of gas is conveyed to the analyser and VO2 and VCO2 are measured and converted in energy expenditure. (wikipedia.org)
- There is currently no universally recommended and accepted method of data processing within the science of indirect calorimetry for either mixing chamber or breath-by-breath systems of expired gas analysis. (edu.au)
- Breath-by-breath datasets obtained from indirect calorimetry during incremental exercise were then used to demonstrate the consequences of commonly used time, breath and digital filter post-acquisition data processing strategies. (edu.au)
Obese1
- The adequate provision of energy for obese patients by estimation without indirect calorimetry (IC) is challenging. (bvsalud.org)
Utilization1
- McClave SA, Snider HL, Greene L, et al (1992) Effective utilization of indirect calorimetry during critical care. (springer.com)
Calibration1
- This calibration study, using indirect calorimetry, suggests that the two accelerometers can be used to distinguish differing levels of physical activity intensity as well as inactivity among children 5 to 8 years of age. (nih.gov)
Clinical3
- Baxter International Inc. (NYSE: BAX), a global leader in clinical nutrition, today announced the U.S. Food and Drug Administration (FDA) clearance of Q-NRG+ , a metabolic monitoring device utilizing indirect calorimetry (IC) technology. (baxter.com)
- McClave SA, Snider HL (1992) Use of indirect calorimetry in clinical nutrition. (springer.com)
- Hickman, Ingrid J. / Feasibility and acceptability of implementing indirect calorimetry into routine clinical care of patients with spinal cord injury . (edu.au)
Calorimetric1
- From the indirect calorimetric calculations it appeared that anoxic goldfish also produce fat. (biologists.org)
Calorimeters2
- Although the development of indirect calorimetry dates back over 200 years, its greatest use has been in the last two decades with the development of total parenteral nutrition, interdisciplinary nutrition support teams, and the production of portable, reliable, relatively inexpensive calorimeters. (wikipedia.org)
- Determining the Accuracy and Reliability of Indirect Calorimeters Utilizing the Methanol Combustion Technique. (indirectcalorimetry.net)
Intensive1
- REE was measured using indirect calorimetry during intubation, or at 9 a.m. on postoperative day 1 in the intensive care unit. (fujita-hu.ac.jp)
Conclusions1
- Conclusions: Indirect calorimetry could improve the reliability of lactose malabsorption diagnosis. (archives-ouvertes.fr)
Substrates1
- The term calculate what percentage of energy expenditure is 'direct calorimetry' is used when the rate of heat being supported by each of the two energy production is directly measured by placing a person substrates. (yudu.com)
Patients1
- Indirect calorimetry to measure energy expenditure, and pulse dye densitometry for a hemodynamic study were performed in patients until 14 POD. (biomedsearch.com)
Gold standard2
- Indirect calorimetry is the gold standard to measure energy expenditure. (bioportfolio.com)
- Indirect calorimetry (IC) is the gold standard for measuring BEE. (scielo.br)
Exercise2
- Exercise physiologists need to agree on, and continually refine through empirical research, a consistent process for analysing data from indirect calorimetry. (edu.au)
- The effect of oral L-ornithine hydrochloride (0.1 g/kg BW) on energy expenditure during a rest period from 120 to 180 min after resistance exercise was evaluated by indirect calorimetry. (scirp.org)
Assessment1
- 001). The Bland and Altman method showed good agreement in the assessment of energy expenditure between the indirect calorimetry and the data obtained by the accelerometer. (biomedcentral.com)
Requirements2
- Intervention goal: delivering 100% of patient-specific requirements, measured or calculated throughout entire admission (EN+PN). (clinicaltrials.gov)
- The target goal of enteral nutrition (EN) (defined by energy requirements) should be determined and clearly identified at the time of initiation of nutrition support therapy. (nap.edu)
Test1
- An indirect calorimetry test requires two simple 10-minute breathing tests. (nationaljewish.org)
Production2
- Indirect calorimetry measures O2 consumption and CO2 production. (wikipedia.org)
- The term 'indirect There is, however, a third macronutrient that is calorimetry' is used when heat production is not oxidized to produce energy. (yudu.com)
Body1
- We used indirect calorimetry to determine the energy expenditure (EE) in response to body position changes, and we assessed EE's correlation with respiratory parameters in healthy volunteers: 8 males and 8 females, mean age 23.4±1.3 years. (okayama-u.ac.jp)
Stress1
- The total energy expenditure during rest and mild cold stress was measured by indirect calorimetry. (pubmedcentralcanada.ca)
Studies1
- The indirect calorimetry studies are performed at the the Climate Respiration Unit of the Department of Animal Sciences within the Wageningen University. (wur.nl)
Measure1
- Indirect calorimetry is combined with an on line technique to measure 13CO2 enrichment. (wur.nl)