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Caloric RestrictionCaloric TestsLongevityEnergy IntakeAgingDiet, ReducingFood DeprivationWeight LossBody WeightSirtuinsEnergy MetabolismSirtuin 1DNA Restriction EnzymesObesityPolymorphism, Restriction Fragment LengthEatingRats, Inbred F344Body CompositionStilbenesAdipose TissueCheirogaleidaeFastingOxidative StressDietSirtuin 3Mice, Inbred C57BLLeptinExercisePhysical Conditioning, AnimalInsulinMuscle, SkeletalPeganumGastric BypassDietary CarbohydratesHungerFeeding BehaviorOverweightDeoxyribonucleases, Type II Site-SpecificMacaca mulattaDietary FatsLiverBasal MetabolismTime FactorsDietary ProteinsAdiposityGhrelinOxygen ConsumptionWeight GainAzaserineInsulin ResistanceAMP-Activated Protein KinasesObesity, MorbidMitochondriaBlood GlucoseBase SequenceGene Expression RegulationHypothalamusSarcopeniaOrgan SizeGlucoseLife ExpectancyBody Mass IndexAdaptation, PhysiologicalInsulin-Like Growth Factor IMitochondria, MuscleNystagmus, PhysiologicMotor ActivityTriglyceridesRats, WistarRats, Inbred BNLipid MetabolismHomeostasisMice, ObesePhysical ExertionStarvationRandom AllocationDNA, MitochondrialAdenylate KinaseBiomimetic Materials
Caloric Restriction
Reduction in caloric intake without reduction in adequate nutrition. In experimental animals, caloric restriction has been shown to extend lifespan and enhance other physiological variables.
Caloric Tests
Elicitation of a rotatory nystagmus by stimulating the semicircular canals with water or air which is above or below body temperature. In warm caloric stimulation a rotatory nystagmus is developed toward the side of the stimulated ear; in cold, away from the stimulated side. Absence of nystagmus indicates the labyrinth is not functioning.
Longevity
The normal length of time of an organism's life.
Energy Intake
Total number of calories taken in daily whether ingested or by parenteral routes.
Aging
The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
Diet, Reducing
A diet designed to cause an individual to lose weight.
Food Deprivation
The withholding of food in a structured experimental situation.
Weight Loss
Decrease in existing BODY WEIGHT.
Body Weight
The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.
Sirtuins
A homologous family of regulatory enzymes that are structurally related to the protein silent mating type information regulator 2 (Sir2) found in Saccharomyces cerevisiae. Sirtuins contain a central catalytic core region which binds NAD. Several of the sirtuins utilize NAD to deacetylate proteins such as HISTONES and are categorized as GROUP III HISTONE DEACETYLASES. Several other sirtuin members utilize NAD to transfer ADP-RIBOSE to proteins and are categorized as MONO ADP-RIBOSE TRANSFERASES, while a third group of sirtuins appears to have both deacetylase and ADP ribose transferase activities.
Energy Metabolism
The chemical reactions involved in the production and utilization of various forms of energy in cells.
Sirtuin 1
A sirtuin family member found primarily in the CELL NUCLEUS. It is an NAD-dependent deacetylase with specificity towards HISTONES and a variety of proteins involved in gene regulation.
DNA Restriction Enzymes
Enzymes that are part of the restriction-modification systems. They catalyze the endonucleolytic cleavage of DNA sequences which lack the species-specific methylation pattern in the host cell's DNA. Cleavage yields random or specific double-stranded fragments with terminal 5'-phosphates. The function of restriction enzymes is to destroy any foreign DNA that invades the host cell. Most have been studied in bacterial systems, but a few have been found in eukaryotic organisms. They are also used as tools for the systematic dissection and mapping of chromosomes, in the determination of base sequences of DNAs, and have made it possible to splice and recombine genes from one organism into the genome of another. EC 3.21.1.
Obesity
A status with BODY WEIGHT that is grossly above the acceptable or desirable weight, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).
Polymorphism, Restriction Fragment Length
Variation occurring within a species in the presence or length of DNA fragment generated by a specific endonuclease at a specific site in the genome. Such variations are generated by mutations that create or abolish recognition sites for these enzymes or change the length of the fragment.
Eating
The consumption of edible substances.
Rats, Inbred F344
Body Composition
The relative amounts of various components in the body, such as percentage of body fat.
Stilbenes
Organic compounds that contain 1,2-diphenylethylene as a functional group.
Adipose Tissue
Specialized connective tissue composed of fat cells (ADIPOCYTES). It is the site of stored FATS, usually in the form of TRIGLYCERIDES. In mammals, there are two types of adipose tissue, the WHITE FAT and the BROWN FAT. Their relative distributions vary in different species with most adipose tissue being white.
Cheirogaleidae
A family of the order PRIMATES, suborder Strepsirhini (PROSIMII), containing five genera. All inhabitants of Madagascar, the genera are: Allocebus, Cheirogaleus (dwarf lemurs), Microcebus (mouse lemurs), Mirza, and Phaner.
Fasting
Abstaining from all food.
Oxidative Stress
A disturbance in the prooxidant-antioxidant balance in favor of the former, leading to potential damage. Indicators of oxidative stress include damaged DNA bases, protein oxidation products, and lipid peroxidation products (Sies, Oxidative Stress, 1991, pxv-xvi).
Diet
Regular course of eating and drinking adopted by a person or animal.
Sirtuin 3
A sirtuin family member found primarily in MITOCHONDRIA. It is a multifunctional enzyme that contains a NAD-dependent deacetylase activity that is specific for HISTONES and a mono-ADP-ribosyltransferase activity.
Mice, Inbred C57BL
Leptin
A 16-kDa peptide hormone secreted from WHITE ADIPOCYTES. Leptin serves as a feedback signal from fat cells to the CENTRAL NERVOUS SYSTEM in regulation of food intake, energy balance, and fat storage.
Exercise
Physical activity which is usually regular and done with the intention of improving or maintaining PHYSICAL FITNESS or HEALTH. Contrast with PHYSICAL EXERTION which is concerned largely with the physiologic and metabolic response to energy expenditure.
Physical Conditioning, Animal
Diet modification and physical exercise to improve the ability of animals to perform physical activities.
Insulin
A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1).
Muscle, Skeletal
A subtype of striated muscle, attached by TENDONS to the SKELETON. Skeletal muscles are innervated and their movement can be consciously controlled. They are also called voluntary muscles.
Peganum
A plant genus of the family ZYGOPHYLLACEAE. Harmala and other ALKALOIDS, phenylpropanoids, and TRITERPENES have been found in plants of this genus.
Gastric Bypass
Surgical procedure in which the STOMACH is transected high on the body. The resulting small proximal gastric pouch is joined to any parts of the SMALL INTESTINE by an end-to-side SURGICAL ANASTOMOSIS, depending on the amounts of intestinal surface being bypasses. This procedure is used frequently in the treatment of MORBID OBESITY by limiting the size of functional STOMACH, food intake, and food absorption.
Dietary Carbohydrates
Carbohydrates present in food comprising digestible sugars and starches and indigestible cellulose and other dietary fibers. The former are the major source of energy. The sugars are in beet and cane sugar, fruits, honey, sweet corn, corn syrup, milk and milk products, etc.; the starches are in cereal grains, legumes (FABACEAE), tubers, etc. (From Claudio & Lagua, Nutrition and Diet Therapy Dictionary, 3d ed, p32, p277)
Hunger
The desire for FOOD generated by a sensation arising from the lack of food in the STOMACH.
Feeding Behavior
Behavioral responses or sequences associated with eating including modes of feeding, rhythmic patterns of eating, and time intervals.
Overweight
A status with BODY WEIGHT that is above certain standard of acceptable or desirable weight. In the scale of BODY MASS INDEX, overweight is defined as having a BMI of 25.0-29.9 kg/m2. Overweight may or may not be due to increases in body fat (ADIPOSE TISSUE), hence overweight does not equal "over fat".
Deoxyribonucleases, Type II Site-Specific
Enzyme systems containing a single subunit and requiring only magnesium for endonucleolytic activity. The corresponding modification methylases are separate enzymes. The systems recognize specific short DNA sequences and cleave either within, or at a short specific distance from, the recognition sequence to give specific double-stranded fragments with terminal 5'-phosphates. Enzymes from different microorganisms with the same specificity are called isoschizomers. EC 3.1.21.4.
Macaca mulatta
A species of the genus MACACA inhabiting India, China, and other parts of Asia. The species is used extensively in biomedical research and adapts very well to living with humans.
Dietary Fats
Fats present in food, especially in animal products such as meat, meat products, butter, ghee. They are present in lower amounts in nuts, seeds, and avocados.
Liver
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
Basal Metabolism
Heat production, or its measurement, of an organism at the lowest level of cell chemistry in an inactive, awake, fasting state. It may be determined directly by means of a calorimeter or indirectly by calculating the heat production from an analysis of the end products of oxidation within the organism or from the amount of oxygen utilized.
Time Factors
Elements of limited time intervals, contributing to particular results or situations.
Dietary Proteins
Proteins obtained from foods. They are the main source of the ESSENTIAL AMINO ACIDS.
Adiposity
The amount of fat or lipid deposit at a site or an organ in the body, an indicator of body fat status.
Ghrelin
A 28-amino acid, acylated, orexigenic peptide that is a ligand for GROWTH HORMONE SECRETAGOGUE RECEPTORS. Ghrelin is widely expressed but primarily in the stomach in the adults. Ghrelin acts centrally to stimulate growth hormone secretion and food intake, and peripherally to regulate energy homeostasis. Its large precursor protein, known as appetite-regulating hormone or motilin-related peptide, contains ghrelin and obestatin.
Oxygen Consumption
The rate at which oxygen is used by a tissue; microliters of oxygen STPD used per milligram of tissue per hour; the rate at which oxygen enters the blood from alveolar gas, equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body. (Stedman, 25th ed, p346)
Weight Gain
Increase in BODY WEIGHT over existing weight.
Azaserine
Antibiotic substance produced by various Streptomyces species. It is an inhibitor of enzymatic activities that involve glutamine and is used as an antineoplastic and immunosuppressive agent.
Insulin Resistance
Diminished effectiveness of INSULIN in lowering blood sugar levels: requiring the use of 200 units or more of insulin per day to prevent HYPERGLYCEMIA or KETOSIS.
AMP-Activated Protein Kinases
Intracellular signaling protein kinases that play a signaling role in the regulation of cellular energy metabolism. Their activity largely depends upon the concentration of cellular AMP which is increased under conditions of low energy or metabolic stress. AMP-activated protein kinases modify enzymes involved in LIPID METABOLISM, which in turn provide substrates needed to convert AMP into ATP.
Obesity, Morbid
The condition of weighing two, three, or more times the ideal weight, so called because it is associated with many serious and life-threatening disorders. In the BODY MASS INDEX, morbid obesity is defined as having a BMI greater than 40.0 kg/m2.
Mitochondria
Semiautonomous, self-reproducing organelles that occur in the cytoplasm of all cells of most, but not all, eukaryotes. Each mitochondrion is surrounded by a double limiting membrane. The inner membrane is highly invaginated, and its projections are called cristae. Mitochondria are the sites of the reactions of oxidative phosphorylation, which result in the formation of ATP. They contain distinctive RIBOSOMES, transfer RNAs (RNA, TRANSFER); AMINO ACYL T RNA SYNTHETASES; and elongation and termination factors. Mitochondria depend upon genes within the nucleus of the cells in which they reside for many essential messenger RNAs (RNA, MESSENGER). Mitochondria are believed to have arisen from aerobic bacteria that established a symbiotic relationship with primitive protoeukaryotes. (King & Stansfield, A Dictionary of Genetics, 4th ed)
Blood Glucose
Glucose in blood.
Base Sequence
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
Gene Expression Regulation
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.
Hypothalamus
Ventral part of the DIENCEPHALON extending from the region of the OPTIC CHIASM to the caudal border of the MAMMILLARY BODIES and forming the inferior and lateral walls of the THIRD VENTRICLE.
Sarcopenia
Progressive decline in muscle mass due to aging which results in decreased functional capacity of muscles.
Organ Size
The measurement of an organ in volume, mass, or heaviness.
Glucose
A primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. It is used therapeutically in fluid and nutrient replacement.
Life Expectancy
Based on known statistical data, the number of years which any person of a given age may reasonably expected to live.
Body Mass Index
An indicator of body density as determined by the relationship of BODY WEIGHT to BODY HEIGHT. BMI=weight (kg)/height squared (m2). BMI correlates with body fat (ADIPOSE TISSUE). Their relationship varies with age and gender. For adults, BMI falls into these categories: below 18.5 (underweight); 18.5-24.9 (normal); 25.0-29.9 (overweight); 30.0 and above (obese). (National Center for Health Statistics, Centers for Disease Control and Prevention)
Adaptation, Physiological
The non-genetic biological changes of an organism in response to challenges in its ENVIRONMENT.
Insulin-Like Growth Factor I
A well-characterized basic peptide believed to be secreted by the liver and to circulate in the blood. It has growth-regulating, insulin-like, and mitogenic activities. This growth factor has a major, but not absolute, dependence on GROWTH HORMONE. It is believed to be mainly active in adults in contrast to INSULIN-LIKE GROWTH FACTOR II, which is a major fetal growth factor.
Mitochondria, Muscle
Mitochondria of skeletal and smooth muscle. It does not include myocardial mitochondria for which MITOCHONDRIA, HEART is available.
Nystagmus, Physiologic
Involuntary rhythmical movements of the eyes in the normal person. These can be naturally occurring as in end-position (end-point, end-stage, or deviational) nystagmus or induced by the optokinetic drum (NYSTAGMUS, OPTOKINETIC), caloric test, or a rotating chair.
Motor Activity
The physical activity of a human or an animal as a behavioral phenomenon.
Triglycerides
Rats, Wistar
A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.
Rats, Inbred BN
Lipid Metabolism
Physiological processes in biosynthesis (anabolism) and degradation (catabolism) of LIPIDS.
Homeostasis
The processes whereby the internal environment of an organism tends to remain balanced and stable.
Mice, Obese
Mutant mice exhibiting a marked obesity coupled with overeating, hyperglycemia, hyperinsulinemia, marked insulin resistance, and infertility when in a homozygous state. They may be inbred or hybrid.
Physical Exertion
Expenditure of energy during PHYSICAL ACTIVITY. Intensity of exertion may be measured by rate of OXYGEN CONSUMPTION; HEAT produced, or HEART RATE. Perceived exertion, a psychological measure of exertion, is included.
Starvation
Lengthy and continuous deprivation of food. (Stedman, 25th ed)
Random Allocation
A process involving chance used in therapeutic trials or other research endeavor for allocating experimental subjects, human or animal, between treatment and control groups, or among treatment groups. It may also apply to experiments on inanimate objects.
DNA, Mitochondrial
Double-stranded DNA of MITOCHONDRIA. In eukaryotes, the mitochondrial GENOME is circular and codes for ribosomal RNAs, transfer RNAs, and about 10 proteins.
Adenylate Kinase
An enzyme that catalyzes the phosphorylation of AMP to ADP in the presence of ATP or inorganic triphosphate. EC 2.7.4.3.
Biomimetic Materials
Materials fabricated by BIOMIMETICS techniques, i.e., based on natural processes found in biological systems.

The effect of dietary restriction during development in utero on the frequency of spontaneous somatic mutations. (1/1289)

Caloric or dietary restriction is known to be protective against cancer in humans and in mice but the mechanism is uncertain. Given that somatic mutations are important in carcinogenesis, dietary restriction may act by changing mutation rates. Indeed, previous studies have shown that reductions in caloric intake during development or in adult life make mice less susceptible to high doses of mutagens. In these studies there have been hints that the spontaneous mutant frequency may also be reduced, but no significant decrease has been observed save in one study of very old mice. Since the spontaneous mutant frequency is already low, reductions from this level require the use of much larger sample sizes than usual and larger than those used in the previous studies. As pre-existing mutations cannot be eliminated, it is necessary to reduce the dietary intake over a period of time when a substantial proportion of spontaneous mutations arise in order to see an effect. To overcome such problems, the dietary restriction in this study was applied during the time of the highest mutation rate, early development, and many more than the usual number of animals were studied. SWR female mice were crossed with Muta(TM)Mouse males to obtain F(1) progeny for analysis of mutant frequency. At conception, the dams were put into two groups, one that was fed ad libitum and another which was fed 80% of the ad libitum diet. Pups were killed at birth, DNA was extracted from the whole animal and used to measure the mutant frequencies of the mice at the cII locus. Although the weights of the pups from dams whose diet was restricted were significantly less than those of the ad libitum mice (P = 0.003), the litter sizes in the two groups were approximately the same and did not differ significantly (P = 0.13). There was no significant difference in the mutant frequencies in the dietarily restricted and ad libitum groups (P = 0.43). In addition, there was no significant correlation between the weights of the pups and their mutant frequency in either the ad libitum or dietarily restricted groups (r(2) = 0.14 and r(2) = 0.024). No difference was observed in mutant frequency between the ad libitum and dietarily restricted mice from litters of the same size (P = 0.61). These results indicate that the protective effect of dietary restriction on cancer rates is not mediated by an alteration in the spontaneous rate of mutation but rather by another mechanism, such as its effect on induced mutation.  (+info)

Evidence that the decrease in liver glycogen is associated with the exercise-induced increase in IGFBP-1. (2/1289)

The purpose of the present study was to test the hypothesis that the exercise-induced increase in insulin-like growth factor binding protein (IGFBP)-1 is not always linked to a decrease in blood glucose level and to examine whether the decreasing levels of liver glycogen during exercise may be associated with the increase in IGFBP-1. Three groups of rats were submitted to a 70-min treadmill exercise. One group of rats was fed normally, and the two other groups had their food intake restricted by 50% (50% fast) the night before the experiment. One of these two 50% fasted groups of rats was infused (intravenously) with glucose throughout exercise to maintain euglycemia. Exercise in noninfused 50% fasted rats, compared with the normally fed rats, resulted in significantly lower blood glucose (minute 70) and insulin levels, significantly lower liver glycogen content, no change in IGF-I, and significantly higher increases in free fatty acid, glycerol, beta-hydroxybutyrate, and IGFBP-1. Maintenance of euglycemia during exercise in glucose-infused 50% fasted rats reduced to a large extent the decrease in insulin levels but only slightly attenuated the lipid response and the IGFBP-1 response seen in noninfused 50% fasted rats. Comparisons of all individual liver glycogen and IGFBP-1 values revealed that liver glycogen values were highly (P < 0.001) predictive of the IGFBP-1 response during exercise (R = 0.564). The present results indicate that the IGFBP-1 response during exercise is not always linked to a decrease in plasma glucose and suggest that the increase in IGFBP-1 during exercise may be related to the decrease in liver glycogen content.  (+info)

Upregulated promitogenic signaling via cytokines and growth factors: potential mechanism of robust liver tissue repair in calorie-restricted rats upon toxic challenge. (3/1289)

Previously we reported that moderate calorie restriction or diet restriction (DR, calories reduced by 35% for 21 days) in male Sprague-Dawley rats protects from a lethal dose of thioacetamide (TA). DR rats had 70% survival compared with 10% in rats fed ad libitum (AL) because of timely and adequate compensatory liver cell division and tissue repair in the DR rats. Further investigation of the mechanisms indicate that enhanced promitogenic signaling plays a critical role in this stimulated tissue repair. Expression of stimulators of promitogenic signaling interleukin-6 (IL-6), inducible nitric oxide synthase (iNOS), hepatocyte growth factor (HGF), transforming growth factor-alpha (TGF-alpha), and epidermal growth factor receptor (EGFR) were studied during liver tissue repair after TA-induced liver injury. Plasma IL-6 was significantly higher in the DR rats, with 6-fold higher expression at 48 h after TA administration. Immunohistochemical localization revealed significantly higher expression of IL-6 in the hepatic sinusoidal endothelium of DR rats. Expression of TGF-alpha and HGF was consistently higher in the livers of DR rats from 36 to 72 h. EGFR, which serves as a receptor for TGF-alpha, was higher in DR rats before TA administration and remained higher till 48 h after TA intoxication. DR-induced 2-fold increase in hepatic iNOS activity is consistent with early cell division in DR rats after TA challenge. These data suggest that the reason behind the higher liver tissue repair after TA-induced hepatotoxicity in DR rats is timely and higher expression of the growth stimulatory cytokines and growth factors. It appears that the physiological effects of DR make the liver cells vigilant and prime the liver tissue promptly for liver regeneration through promitogenic signaling upon toxic challenge.  (+info)

Chaperones come of age. (4/1289)

Chaperone function plays a key role in repairing proteotoxic damage, in the maintenance of cell architecture, and in cell survival. Here, we summarize our current knowledge about changes in chaperone expression and function in the aging process, as well as their involvement in longevity and cellular senescence.  (+info)

High osmolarity extends life span in Saccharomyces cerevisiae by a mechanism related to calorie restriction. (5/1289)

Calorie restriction (CR) extends life span in many different organisms, including mammals. We describe here a novel pathway that extends the life span of Saccharomyces cerevisiae mother cells but does not involve a reduction in caloric content of the media, i.e., there is growth of yeast cells in the presence of a high concentration of external osmolytes. Like CR, this longevity-promoting response to high osmolarity requires SIR2, suggesting a common mechanism of life span regulation. Genetic and microarray analysis indicates that high osmolarity extends the life span by activating Hog1p, leading to an increase in the biosynthesis of glycerol from glycolytic intermediates. This metabolic shift likely increases NAD levels, thereby activating Sir2p and promoting longevity.  (+info)

Effect of low protein and low energy diet on physiological status and digestibility of F344 rats. (6/1289)

A long-term raising study was carried out on male F344/DuCrj rats with three low protein (Crude Protein (CP); 14.5, 11.5, 8.5%) and low energy (Digestible Energy (DE); 2.0 kcal/g) diets from 4 to 104 weeks of age. In rats fed the 8.5% CP diet, body weight and digestible crude protein (DCP) consumption at 10 weeks of age were lower (P < 0.05) but the body weight at 50 weeks of age was higher (P < 0.05) than in the other groups. In rats fed the 8.5% CP diet the crude fat digestibility was higher (P < 0.05), and the CP/nitrogen-corrected metabolizable energy (MEn) ratio was low. On the other hand, the mean survival time at 80 weeks of age was shorter in rats fed the 8.5% CP diet (P < 0.05).  (+info)

Differentiation between obesity and insulin resistance in the association with C-reactive protein. (7/1289)

BACKGROUND: Plasma C-reactive protein (CRP) concentrations are increased in obese and/or hyperinsulinemic individuals. The goal of this study was to determine if the relation between insulin resistance and CRP was independent of obesity. METHODS AND RESULTS: Plasma CRP concentrations were measured before and after 3 months of calorie restriction in 38 healthy, obese women. Steady-state plasma glucose (SSPG) concentration during a 180-minute infusion of octreotide, glucose, and insulin was used to stratify participants into insulin-resistant (IR, n=20) or insulin-sensitive (n=18) groups, similar in terms of mean age (46+/-2 versus 44+/-2 years), body mass index (32.0+/-0.4 versus 31.4+/-0.3 kg/m2), and waist circumference (96+/-2 versus 95+/-2 cm). Mean CRP (0.39+/-0.08 versus 0.12+/-0.03 mg/dL, P=0.003) concentrations were higher in the IR group, as were day-long plasma glucose and insulin responses (P<0.001). There was a significant correlation at baseline between CRP and day-long plasma integrated insulin response (r=0.47, P=0.001) but not between CRP and body mass index (r=0.14) or waist circumference (r=0.10). Weight loss was similar in the two groups (8.7+/-0.9 versus 8.4+/-0.8 kg) but was associated with significant (P<0.001) decreases in SSPG and CRP concentrations in the IR group only. Regression analysis showed that SSPG and day-long plasma insulin response were the only significant predictors of CRP concentration. CONCLUSIONS: CRP concentrations are elevated predominantly in obese individuals who are also insulin resistant and fall in parallel with weight loss-associated improvements in insulin resistance. The relation between CRP concentrations and insulin resistance is independent of obesity.  (+info)

Lifelong caloric restriction increases expression of apoptosis repressor with a caspase recruitment domain (ARC) in the brain. (8/1289)

Aging may increase apoptotic events and the susceptibility of the central nervous system to apoptosis. Calorie restriction has been shown to have neuroprotective effects, but the mechanisms in vivo are unknown. We investigated apoptosis and apoptotic regulatory proteins in the brain frontal cortex of 12-month-old ad libitum fed, 26-month-old ad libitum fed, and 26-month-old calorie-restricted (CR) male Fischer 344 rats (CR = 40% restricted compared to ad libitum). We found that specific DNA fragmentation indicative of apoptosis was increased with age (+124%) in the cortices of the brain and that calorie restriction attenuated this increase significantly (-36%). We determined levels of ARC (apoptosis repressor with a caspase recruitment domain), which inhibits caspase-2 activity and also attenuates cytochrome c release from the mitochondria. We found a significant age-associated decline in ARC level, which was attenuated in the brains of the CR rats. In accordance with the changes in ARC expression observed, calorie restriction attenuated the increases in cytosolic cytochrome c and caspase-2 activity with age and suppressed the age-associated rise in cleaved caspase-9 and cleaved caspase-3. However, neither age nor calorie restriction had any effect on caspase-3 and caspase-9 activities. This data provides evidence for an increased incidence of apoptosis in rat brain with age and evidence that calorie restriction has the ability to attenuate this. Furthermore, our data suggest that calorie restriction provides neuroprotection through ARC by suppressing cytochrome c release and caspase-2 activity.  (+info)

Very Low Calorie Diet - Very Low Calorie Diet Safety & Side EffectsVery Low Calorie Diet - Very Low Calorie Diet Safety & Side Effects
Very low calorie diets and diabetes have recently hit the headlines since a study by Newcastle University found that a very low calorie diet was effective in reversing the symptoms of type 2 diabetes.
https://www.diabetes.co.uk/diet/very-low-calorie-diet.html
Adipose tissue energy metabolism: altered gene expression profile of mice subjected to long-term caloric restriction | RTIAdipose tissue energy metabolism: altered gene expression profile of mice subjected to long-term caloric restriction | RTI
We investigated the influences of short-term and lifespan-prolonging long-term caloric restriction (LCR) on gene expression in white adipose tissue (WAT). Over 11,000 genes were examined using high-density oligonucleotide microarrays in four groups of 10- to 11-month-old male C57Bl6 mice that were either fasted for 18 h before death (F), subjected to short-term caloric restriction for 23 days (SCR), or LCR for 9 months and compared with nonfasted control (CO) mice. Only a few transcripts of F and SCR were differentially expressed compared with CO mice.
https://www.rti.org/publication/adipose-tissue-energy-metabolism-altered-gene-expression-profile-mice-subjected-long-0
Plus itPlus it
In this study, we provide additional evidence in support of the hypothesis that decreased caloric intake has a protective effect on MT development. Specifically, we show that a decrease in caloric intake, whether administered as chronic caloric restriction or as intermittent caloric restriction/refeeding, protects against oncogene-induced MT development. However, an identical decrease in calories and nutrients consumed by intermittent caloric restriction/refeeding was more effective in both delaying the age of MT detection and in lowering overall MT incidence than were those consumed by chronic caloric restriction.. These new findings are in contrast to the results of two previous studies that assessed the effects of chemical carcinogen-induced MT development in rats subjected to two different intermittent caloric restriction/refeeding protocols (14 , 15) . In one of these studies (14) , the degree of food restriction was substantially different between chronically calorie-restricted rats (60% ...
http://cebp.aacrjournals.org/content/11/9/836
Caloric restriction delays age-related methylation drift | Nature CommunicationsCaloric restriction delays age-related methylation drift | Nature Communications
In mammals, caloric restriction consistently results in extended lifespan. Epigenetic information encoded by DNA methylation is tightly regulated, but shows a striking drift associated with age that includes both gains and losses of DNA methylation at various sites. Here, we report that epigenetic drift is conserved across species and the rate of drift correlates with lifespan when comparing mice, rhesus monkeys, and humans. Twenty-two to 30-year-old rhesus monkeys exposed to 30% caloric restriction since 7-14 years of age showed attenuation of age-related methylation drift compared to ad libitum-fed controls such that their blood methylation age appeared 7 years younger than their chronologic age. Even more pronounced effects were seen in 2.7-3.2-year-old mice exposed to 40% caloric restriction starting at 0.3 years of age. The effects of caloric restriction on DNA methylation were detectable across different tissues and correlated with gene expression. We propose that epigenetic drift is a determinant
https://www.nature.com/articles/s41467-017-00607-3?error=cookies_not_supported&code=369848b3-7e37-44b8-a9dc-121ca1476545
with low calorie diets low blood sugar levels can be maintained - Diabetesadvicewebwith low calorie diets low blood sugar levels can be maintained - Diabetesadviceweb
Diabetes patients are required to closely monitor their carbohydrate and sugar intake. In order that your blood sugar levels are stabilized you will each day eat approximately that same amount of food at the same time. Diabetes patients are often advised to lose weight and as such the consumption of low calorie diet is important. Low calorie diabetic diet plan makes life of diabetics less stressful. The diabetics chances of following their new dietary guidelines increases with advance knowledge of what they will be eating. With prior knowledge you will be worrying less about having diabetes and will enjoy life the way that you want. Hence, by following a low calorie diets, low blood sugar levels can be maintained and this makes eating and living with diabetes quite simple.. Low calories diets simply mean you will have a reduction in calorie intake by lowering the amount of food you eat each day. The calorie intake will be just below what you need to maintain your current weight. However, low ...
https://diabetesadviceweb.com/diabetes/blood-sugar/with-low-calorie-diets-low-blood-sugar-levels-can-be-maintained/
Chronological analysis of caloric restriction-induced alteration of fatty acid biosynthesis in white adipose tissue of rats<...
TY - JOUR. T1 - Chronological analysis of caloric restriction-induced alteration of fatty acid biosynthesis in white adipose tissue of rats. AU - Okita, Naoyuki. AU - Tsuchiya, Takuro. AU - Fukushima, Mayumi. AU - Itakura, Kaho. AU - Yuguchi, Keiko. AU - Narita, Takumi. AU - Hashizume, Yukari. AU - Sudo, Yuka. AU - Chiba, Takuya. AU - Shimokawa, Isao. AU - Higami, Yoshikazu. PY - 2015/3/1. Y1 - 2015/3/1. N2 - The beneficial actions of caloric restriction (CR) could be mediated in part by metabolic remodeling of white adipose tissue (WAT). Recently, we suggested that CR for 6. months increased the expressions of proteins involved in de novo fatty acid (FA) biosynthesis in WAT of 9-month-old rats. Herein, we compared the CR-induced chronological alterations of the expression of mRNAs and/or proteins involved in FA biosynthesis in the WAT and liver of rats subjected to CR starting from 3. months of age and their age-matched controls fed ad libitum. The findings suggested that CR was more effective ...
https://waseda.pure.elsevier.com/en/publications/chronological-analysis-of-caloric-restriction-induced-alteration-
Effects of Caloric Restriction and Dietary Fat on Epithelial Cell Proliferation in Rat Colon | Cancer ResearchEffects of Caloric Restriction and Dietary Fat on Epithelial Cell Proliferation in Rat Colon | Cancer Research
Epidemiological studies indicate that caloric intake and dietary fat content influence colonic carcinogenesis. In rodents, caloric restriction reduces, and some fats increase, carcinogen-induced colon cancer incidence. The present study was designed to investigate the effects of caloric restriction on colonic cell proliferation (CCP) in carcinogen-treated or control rats fed low- or high-fat diets. F344 rats were treated with azoxymethane (15 mg/kg ×2) and then fed an isocaloric AIN 76A diet containing either 5 or 23% corn oil, ad libitum or calorie-restricted to 70 or 80% of the kilocalories consumed by ad libitum rats. Biopsies of the distal colon were taken at 10 and 20 weeks, and rats were sacrificed at 21 or 34 weeks on the experimental diets. Distal CCP was determined by microautoradiography after [3H]thymidine labeling in vitro or presacrifice administration in vivo. The labeling index and number of labeled cells per crypt column were significantly reduced by caloric restriction at all ...
https://cancerres.aacrjournals.org/content/53/12/2745?ijkey=aea5b6c578250808ce7207b679bf478039c53d57&keytype2=tf_ipsecsha
Enzymes of glycerol and glyceraldehyde metabolism in mouse liver: effects of caloric restriction and age on activities |...Enzymes of glycerol and glyceraldehyde metabolism in mouse liver: effects of caloric restriction and age on activities |...
The influence of caloric restriction on hepatic glyceraldehyde- and glycerol-metabolizing enzyme activities of young and old mice were studied. Glycerol kinase and cytoplasmic glycerol-3-phosphate dehydrogenase activities were increased in both young and old CR (calorie-restricted) mice when compared with controls, whereas triokinase increased only in old CR mice. Aldehyde dehydrogenase and aldehyde reductase activities in both young and old CR mice were unchanged by caloric restriction. Mitochondrial glycerol-3-phosphate dehydrogenase showed a trend towards an increased activity in old CR mice, whereas a trend towards a decreased activity in alcohol dehydrogenase was observed in both young and old CR mice. Serum glycerol levels decreased in young and old CR mice. Therefore increases in glycerol kinase and glycerol-3-phosphate dehydrogenase were associated with a decrease in fasting blood glycerol levels in CR animals. A prominent role for triokinase in glyceraldehyde metabolism with CR was also ...
https://portlandpress.com/bioscirep/article-abstract/28/2/107/55477/Enzymes-of-glycerol-and-glyceraldehyde-metabolism
The Risks of Very Low Calorie DietsThe Risks of Very Low Calorie Diets
Very Low Calorie Diets (VLCDs) are popular because of the fast weight loss that can result. However, they arent always what theyre cracked up to be.
https://www.diet-blog.com/08/the_risks_of_very_low_calorie_diets.php?replytocom=26980
Effect of body weight and caloric restriction on serum complement proteins, including factor D/adipsin: Studies in anorexia...
TY - JOUR. T1 - Effect of body weight and caloric restriction on serum complement proteins, including factor D/adipsin. T2 - Studies in anorexia nervosa and obesity. AU - Pomeroy, Claire. AU - Mitchell, J.. AU - Eckert, E.. AU - Raymond, N.. AU - Crosby, R.. AU - Dalmasso, A. P.. PY - 1997. Y1 - 1997. N2 - Complement plays important roles in host immune defences, and recent studies suggest that adipose tissue is an important site of production for some complement proteins. Starvation has been associated with low complement levels, but studied populations have usually had concomitant opportunistic infections or other conditions which might affect complement levels. To determine the impact of body weight and changes in body weight on serum complement, we investigated levels of complement proteins in otherwise healthy patients with a wide range of body weights, including patients with anorexia nervosa before and after treatment, obese dieters before and after weight loss, and normal weight ...
https://ucdavis.pure.elsevier.com/en/publications/effect-of-body-weight-and-caloric-restriction-on-serum-complement
Effects of caloric restriction on neuropathic pain, peripheral nerve degeneration and inflammation in normometabolic and...
TY - JOUR. T1 - Effects of caloric restriction on neuropathic pain, peripheral nerve degeneration and inflammation in normometabolic and autophagy defective prediabetic Ambra1 mice. AU - Coccurello, Roberto. AU - Nazio, Francesca. AU - Rossi, Claudia. AU - De Angelis, Federica. AU - Vacca, Valentina. AU - Giacovazzo, Giacomo. AU - Procacci, Patrizia. AU - Magnaghi, Valerio. AU - Ciavardelli, Domenico. AU - Marinelli, Sara. PY - 2018/12/1. Y1 - 2018/12/1. N2 - There is a growing interest on the role of autophagy in diabetes pathophysiology, where development of neuropathy is one of the most frequent comorbidities. We have previously demonstrated that neuropathic pain after nerve damage is exacerbated in autophagy-defective heterozygous Ambra1 mice. Here, we show the existence of a prediabetic state in Ambra1 mice, characterized by hyperglycemia, intolerance to glucose and insulin resistance. Thus, we further investigate the hypothesis that prediabetes may account for the exacerbation of allodynia ...
https://moh-it.pure.elsevier.com/en/publications/effects-of-caloric-restriction-on-neuropathic-pain-peripheral-ner
Low Calorie Diet Plans: Rich in Complex Carbohydrates and FatLow Calorie Diet Plans: Rich in Complex Carbohydrates and Fat
Low calorie diet foods contribute to fewer calories. Low calorie diets have 1500-1800 calories per day. Rich in complex carbohydrate and low in carbohydrate and fat.
http://www.diethealthclub.com/calories/low-calorie-diet.html
Acervo Digital: Food restriction and refeeding induces changes in lipid pathways and fat deposition in the adipose and hepatic...Acervo Digital: Food restriction and refeeding induces changes in lipid pathways and fat deposition in the adipose and hepatic...
The aim of this study was to determine the effects of successive cycles of a moderately restrictive diet and refeeding with a high-fat diet on the metabolism of the adipose and hepatic tissues of obese rats. Rats were assigned to the following groups: a chow diet; a high-fat diet; a moderate caloric restriction; or a moderate caloric restriction plus refeeding. Some animals in each group were given [1-14C]triolein intragastrically, while others received an intraperitoneal injection of 3 mCi 3H2O. All animals were killed by decapitation. The retroperitoneal, visceral epididymal and omental white adipose tissues, brown adipose tissue, liver and blood were immediately removed. The lipid uptake from the diet, in vivo rate of lipogenesis, percentage of fat, lipid profile and leptin concentration were analysed. The high-fat diet promoted an increase in fatty liver (P= 0.05), adiposity mass (P= 0.05) and the plasma concentration of leptin (P= 0.05) and a decreased lipid uptake in white adipose tissue ...
https://acervodigital.unesp.br/handle/11449/7180
Health Correlator: The China Study II: Does calorie restriction increase longevity?Health Correlator: The China Study II: Does calorie restriction increase longevity?
abdominal discomfort (1) adiponectin (10) adrenaline (1) AGEs (5) aging (2) ALA (1) albumin (1) alcohol (7) aluminium (1) aluminum (1) Alzheimers (1) amino acids (1) anabolic steroids (1) Ancestral Health Symposium (2) Andrew Weil (1) anorexia (2) arrested caries (1) arterial stiffness (3) atherosclerosis (4) Atkins (7) autophagy (1) average faces (1) barefoot running (1) barefoot walking (1) BCAAs (2) beef (2) beef heart (1) beef liver (5) bell curve (1) bile (1) biomagnification (1) bipolar disorder (2) birds (1) bison (1) blood acidity (1) BMI (15) body fat (49) body fat loss (9) boiling (1) bone density (2) book review (4) braces (1) Brazilian sertão (1) butter (1) Cabeza de Vaca (1) cafestol (1) calcium (1) calorie restriction (9) cancer (14) cangaceiros (1) carbohydrates (10) cardiovascular disease (26) carnivore (1) causation without correlation (1) cave painting (2) cheese (5) China Study (17) chlorogenic acid (1) cholesterol (25) chylomicron (3) cirrhosis (1) cliodynamics (1) coconut ...
http://healthcorrelator.blogspot.com/2010/10/china-study-ii-does-calorie-restriction.html
Caloric restriction decreases cortical bone mass but spares trabecular bone in the mouse skeleton: Implications for the...
TY - JOUR. T1 - Caloric restriction decreases cortical bone mass but spares trabecular bone in the mouse skeleton. T2 - Implications for the regulation of bone mass by body weight. AU - Hamrick, Mark W.. AU - Ding, Ke Hong. AU - Ponnala, Sumant. AU - Ferrari, Serge L.. AU - Isales, Carlos M.. PY - 2008/6. Y1 - 2008/6. N2 - Introduction: Body weight is positively correlated with bone mass and density, and both muscle mass and body fat are thought to play a role in regulating bone metabolism. We examined bone metabolism in calorically restricted mice to determine how alterations in soft tissue mass affect bone mass, density, and strength. Materials and Methods: Caloric restriction (CR) was initiated in male mice at 14 wk of age at 10% restriction, increased to 25% restriction at 15 wk, and then increased to 40% restriction at 16 wk, where it was maintained until 24 wk of age when the study was terminated. Control mice were fed ad libitum (AL). Body composition, BMD, and BMC were measured by DXA, ...
https://augusta.pure.elsevier.com/en/publications/caloric-restriction-decreases-cortical-bone-mass-but-spares-trabe
Caloric restriction restores glucose response in diabetesCaloric restriction restores glucose response in diabetes
(HealthDay) -- Neuronal responsiveness of the hypothalamus to glucose, critical in the regulation of feeding, can be restored in patients with type 2 diabetes by short-term caloric restriction, according to a study published ...
https://medicalxpress.com/news/2012-08-caloric-restriction-glucose-response-diabetes.html
Caloric Restriction And Egaing
One of the signs of aging is arteriosclerosis. To lower total cholesterol, follow a diet low in calories and total fats, especially saturated fats, and high in whole grains, fruits, and vegetables. Your physician can help you evaluate other.. Abstract. Calorie restriction (CR) extends life span and retards age-related chronic diseases in a variety of species, including rats, mice, fish.. Calorie restriction or caloric restriction, usually abbreviated to CR, is a strategy proven to extend healthy, average, and maximum life span in many short lived.. (12) Inflammatory- D-galactose in milk is inflammatory and increases sign of aging. Individuals with cows milk allergies. Cow milk offers higher levels of protein, fat, carbs and calories. So its important to consider your nutritional needs.. Recent research shows that calorie restriction may help slow down aging, improve longevity, and fight cancer.. How Much Potassium Do I Need Paleo Diet Potassium-Rich Foods in The Paleo Diet. our modern dietary ...
http://tuberoom.info/caloric-restriction-and-egaing/
Influence of calorie restriction on autoimmune disease. Abstr. by G Fernandes, P Friend et al.Influence of calorie restriction on autoimmune disease. Abstr. by G Fernandes, P Friend et al.
Fernandes, G; Friend, P; and Yunis, E J., Influence of calorie restriction on autoimmune disease. Abstr. (1977). Subject Strain Bibliography 1977. 2532 ...
https://mouseion.jax.org/ssbb1977/2532/
Disruption of Snf3/Rgt2 glucose sensors decreases lifespan and caloric restriction effectiveness through Mth1/Std1 by adjusting...
TY - JOUR. T1 - Disruption of Snf3/Rgt2 glucose sensors decreases lifespan and caloric restriction effectiveness through Mth1/Std1 by adjusting mitochondrial efficiency in yeast. AU - Choi, Kyung Mi. AU - Kwon, Young Yon. AU - Lee, Cheol-Koo. PY - 2015/1/30. Y1 - 2015/1/30. N2 - Down-regulation of intracellular nutrient signal pathways was proposed to be a primary mechanism of caloric restriction (CR)-mediated lifespan extension. However, the link between lifespan and glucose sensors in the plasma membrane was poorly understood in yeast. Herein, a mutant that lacked glucose sensors (snf3Δrgt2Δ) had impaired glucose fermentation, showed decreased chronological lifespan (CLS), and reduced CLS extension by CR. The mutant also had reduced mitochondrial efficiency, as inferred by increased mitochondrial superoxide and decreased ATP levels. Mth1 and Std1, which are downstream effectors of the Snf3/Rgt2 pathway, were required for viability through mitochondrial function but not fermentative ...
https://koreauniv.pure.elsevier.com/en/publications/disruption-of-snf3rgt2-glucose-sensors-decreases-lifespan-and-cal
Is Calorie Restriction the Future? | HowStuffWorksIs Calorie Restriction the Future? | HowStuffWorks
Is Calorie Restriction the Future? - Is calorie restriction the future of anti-aging? Learn about calorie restriction and longevity research and see if calorie restriction can slow aging.
https://health.howstuffworks.com/wellness/aging/anti-aging-tips/restricted-diet-slow-aging2.htm
Double X Science: 100 YearsDouble X Science: 100 Years
You may have heard exclamations about antioxidants or calorie restriction. While antioxidants (the aforementioned vitamin A and vitamin E) are known to protect the body from the harmful effects of free-radicals, which occur in the normal processes of the body, evidence does not support that simply adding more antioxidants to the diet will slow aging. There are studies also showing that calorie restriction may have beneficial effects in terms of markers of aging in some animals, but many animals that are commonly used as human models do not extend longevity under calorie restriction, and such a course of action may have deleterious effects. The safety and benefits of long-term calorie restriction is currently unknown. Scientists are working towards answering these questions. ...
http://www.doublexscience.com/2012/10/100-years.html
A Calorie-Restricted Diet Decreases Brain Iron Accumulation and Preserves Motor Performance in Old Rhesus Monkeys | Journal of...A Calorie-Restricted Diet Decreases Brain Iron Accumulation and Preserves Motor Performance in Old Rhesus Monkeys | Journal of...
Several measures of aging in old monkeys, including sarcopenia, poor glucoregulation, and atrophy of gray matter in the CNS, are favorably affected by a CR diet (Gresl et al., 2003; Colman et al., 2008, 2009; Anderson et al., 2009). Less is known, however, about CRs protective effect on two other markers of brain aging: the accumulation of iron and deteriorating motor performance. Iron concentrations increase naturally with age in deep nuclei (striatum, GP, SN, and RN) in both humans (Bartzokis et al., 2007; Péran et al., 2007; X. Xu et al., 2008) and monkeys (Hardy et al., 2005; Cass et al., 2007). Motor deficits also increase with age and can progress clinically to age-related disorders (Herndon et al., 1997; Lacreuse et al., 1999; Nagahara et al., 2010). In the present study, we confirmed the age-associated increase of iron in a number of brain regions that typically show the most accumulation with age, as indexed by robust negative correlations between age and R2 in GP and SN (Hallgren and ...
http://www.jneurosci.org/content/30/23/7940.long
A Calorie-Restricted Diet Decreases Brain Iron Accumulation and Preserves Motor Performance in Old Rhesus Monkeys | Journal of...A Calorie-Restricted Diet Decreases Brain Iron Accumulation and Preserves Motor Performance in Old Rhesus Monkeys | Journal of...
Several measures of aging in old monkeys, including sarcopenia, poor glucoregulation, and atrophy of gray matter in the CNS are favorably affected by a CR diet (Gresl et al., 2003; Colman et al., 2008, 2009; Anderson et al., 2009). Less is known, however, about CRs protective effect on two other markers of brain aging: the accumulation of iron and deteriorating motor performance. Iron concentrations increase naturally with age in deep nuclei (striatum, GP, SN, and RN) in both humans (Bartzokis et al., 2007; Péran et al., 2007; Xu et al., 2008) and monkeys (Hardy et al., 2005; Cass et al., 2007). Motor deficits also increase with age, and can progress clinically to age-related disorders (Herndon et al., 1997; Lacreuse et al., 1999; Nagahara et al., 2010). In the present study, we confirmed the age-associated increase of iron in a number of brain regions that typically show the most accumulation with age, as indexed by robust negative correlations between Age and T2 in GP and SN (Hallgren and ...
http://www.jneurosci.org/content/32/34/11897.long
Recent Calorie Restriction Research: Monkeys, Squirrels, Mice, and Yeast - Fight Aging!Recent Calorie Restriction Research: Monkeys, Squirrels, Mice, and Yeast - Fight Aging!
Researchers around the world are examining the effects of calorie restriction in many different species, and have been for years. In near all species reducing calorie intake while maintaining optimal levels of vital nutrients extends life and provides numerous health benefits. Spectacular improvements in general health and lowered risk of disease are observed in human practitioners, far more than any presently available medical technology can offer a basically healthy individual, but the jury is still out on the degree to which calorie restriction can extend maximum life span in our species and other longer-lived primates. In part this is due to a lack of data: it takes a long time to run such a study when the only reliable way to measure life extension is to wait and see, and there is little in the way of large sets of historical data to mine. Researchers currently expect calorie restriction to extend human life by only a few years, and the historical absence of evidence bears this out: if ...
https://www.fightaging.org/archives/2013/08/recent-calorie-restriction-research-monkeys-squirrels-mice-and-yeast/
Salk researchers discover first gene that specifically links calorie restriction to longevity - Salk Institute for Biological...Salk researchers discover first gene that specifically links calorie restriction to longevity - Salk Institute for Biological...
Having identified a key link between calorie restriction and aging also opens the door to development of drugs that mimic the effects of calorie restriction and might allow people to reap health benefits without adhering to an austere regimen that only ascetics can endure. Initially, researchers thought that the effect of calorie restriction on aging was mediated through insulin-like signaling pathways in the roundworm Caenorhabditis elegans (C. elegans), but experiments by graduate student Siler Panowski in Dillins lab suggested otherwise.. In the worm, signals passed down the insulin/IGF-1 pathway regulate a DNA-binding protein called DAF-16 that belongs to what is called the forkhead family. It was believed that DAF-16 then regulated expression of genes associated with longevity. Dillin had also identified a co-regulator in the pathway called SMK-1 that apparently worked with DAF-16 to regulate longevity.. When we asked whether DAF-16 and SMK-1 proteins were both necessary for CR-mediated ...
http://www.salk.edu/news-release/salk-researchers-discover-first-gene-that-specifically-links-calorie-restriction-to-longevity/
Why A Low Calorie Diet Plan Will Slow Fat Loss | Fat VanishWhy A Low Calorie Diet Plan Will Slow Fat Loss | Fat Vanish
Many pursue a low calorie diet plan in an effort to achieve their weight loss goal, but such an approach actually slows long term fat loss significantly
https://fatvanish.com/why-a-low-calorie-diet-plan-will-slow-fat-loss/
Whole Oats Supplementation in a Low Calorie Diet Efficiently Reduces Cardio-Metabolic Disorders in Obese Rats | South...Whole Oats Supplementation in a Low Calorie Diet Efficiently Reduces Cardio-Metabolic Disorders in Obese Rats | South...
The hypocaloric diets (HCD) are an approach for controlling weight but can lead to a risk of nutritional deficiency. Whole grain contain bioactive com-pounds with health benefits; their incorporation into HCD can improve their nutritional value due to their richness in soluble fibers and their low glycae-mic index. The effects of incorporating oats in HCD were evaluated on growth parameters, lipid and glycaemic abnormalities, nitric oxide level and redox status in obese rats. Albinos rats were rendered obese after ingestion of a hyperlipidic (HL) diet and were then divided into three homogeneous groups: A first group was submitted for 28 days to a caloric restriction (CR) supplemented with oat (CR-Oat group). The second was fed a CR diet with-out supplementation (CR group) and the third obese group continued to con-sume the HL diet (Ob-HL). A fourth group (T) of normal weight rats is taken as a reference. Body weight, food and energy intake, glycaemia, glycosylated hemoglobin, insulinemia and ...
https://www.sajeb.org/index.php/sajeb/article/view/480
Impact of Caloric Restriction on Health and Survival in Rhesus Monkeys From the NIA Study - PubMedImpact of Caloric Restriction on Health and Survival in Rhesus Monkeys From the NIA Study - PubMed
Calorie restriction (CR), a reduction of 10-40% in intake of a nutritious diet, is often reported as the most robust non-genetic mechanism to extend lifespan and healthspan. CR is frequently used as a tool to understand mechanisms behind ageing and age-associated diseases. In addition to and indepen …
https://pubmed.ncbi.nlm.nih.gov/22932268/
Woman with Meal - 4 Week - Shake That WeightWoman with Meal - 4 Week - Shake That Weight
Achieving a healthy weight target is all about finding the right balance between the amount of energy (kals) you consume and the amount your burn off . If you are actively trying to lose weight then eating healthy meals and maintaining physical fitness is the key to success!. Sometimes you need a bit of extra help, which is where a very low calorie diet or VLCD, can be the correct choice for you. The principal is simple, to lose weight you need to use more energy than you consume. A Very low calorie diet lowers your daily calorie intake significantly more than traditional diets.. This means more rapid weight loss than traditional diets.. VLCD plans like shake that weight are now recognised by the NHS and are openly discussed as a method of successful dieting on NHS choices.. The national institute for clinical excellence (nice) recommends that VLCDs (diets under 1000 calories) should only be followed constantly for 12 weeks and then you should take a break. This diet is also not recommended for ...
https://www.shakethatweight.co.uk/shop/week-plans/woman-meal-4/
A cell non-autonomous mechanism of yeast chronological aging regulated by caloric restriction and one-carbon metabolismA cell non-autonomous mechanism of yeast chronological aging regulated by caloric restriction and one-carbon metabolism
Caloric restriction (CR) improves healthspan and lifespan of organisms ranging from yeast to mammals. Understanding the mechanisms involved will uncover future interventions for aging associated diseases. In budding yeast, Saccharomyces cerevisiae , CR is commonly defined by reduced glucose in the growth medium, which extends both replicative and chronological lifespan (CLS). We found that conditioned media collected from stationary phase CR cultures extended CLS when supplemented into non-restricted (NR) cultures, suggesting a potential cell non-autonomous mechanism of CR-induced lifespan regulation. Chromatography and untargeted metabolomics of the conditioned media, as well as transcriptional responses associated with the longevity effect, pointed to specific amino acids enriched in the CR conditioned media (CRCM) as functional molecules, with L-serine being a particularly strong candidate. Indeed, supplementing L-serine into NR cultures extended CLS through a mechanism dependent on the ...
https://scholars.uab.edu/display/pub2397451
The role of Ames dwarfism and calorie restriction on gut microbiota.The role of Ames dwarfism and calorie restriction on gut microbiota.
The gut microbiome (GM) represents a large and very complex ecosystem of different microorganisms. There is an extensive interest in the potential role of the GM in different diseases including cancer, diabetes, cardiovascular diseases, and aging. The GM changes over the lifespan and is strongly associated with various age-related diseases. Ames dwarf (df/df) mice are characterized by an extended life- and healthspan, and although these mice are protected from many age-related diseases, their microbiome has not been studied. To determine the role of microbiota on longevity animal models, we investigated the changes in the GM of df/df and Normal control (N) mice, by comparing parents before mating and littermate mice at three distinct time points during early life. Furthermore, we studied the effects of a 6-month calorie restriction (CR), the most powerful intervention extending the lifespan. Our data revealed significant changes of the GM composition during early life development, and we ...
https://repository.helmholtz-hzi.de/handle/10033/622030
Caloric restriction improves health-related quality of life in healthy normal weight and overweight individuals | Evidence...Caloric restriction improves health-related quality of life in healthy normal weight and overweight individuals | Evidence...
Studies have demonstrated that caloric restriction (CR) increases longevity in animals and also decreases the risk of diabetes, cardiovascular disease and cancer in humans without obesity.1 ,2 It is hypothesised that these favourable CR effects may be related to a reduction in metabolism, reduced core temperature and lowered triiodothyronine(T3).3 While it is unlikely that studies will ascertain whether CR extends life, intermediate length studies may be able to determine the safety, tolerability and feasibility of CR and its effects on chronic disease development and biomarkers correlated with longevity.2 This study aimed to examine the sustained effects of a 25% CR on health-related quality of life (QOL) in individuals … ...
http://ebm.bmj.com/content/early/2016/12/13/ebmed-2016-110526
Caloric Restriction Leads to High Marrow Adiposity and Low Bone Mass in Growing Mice - PubMedCaloric Restriction Leads to High Marrow Adiposity and Low Bone Mass in Growing Mice - PubMed
The effects of caloric restriction (CR) on the skeleton are well studied in adult rodents and include lower cortical bone mass but higher trabecular bone volume. Much less is known about how CR affects bone mass in young, rapidly growing animals. This is an important problem because low caloric inta …
https://pubmed.ncbi.nlm.nih.gov/20229598/
Whole Health Source: August 2012
Recent findings have caused me to seriously question this narrative. One of the first challenges was the finding that genetically wild mice (as opposed to inbred laboratory strains) do not live longer when their calorie intake is restricted, despite showing hormonal changes associated with longevity in other strains, although the restricted animals do develop less cancer (1). One of the biggest blows came in 2009, when researchers published the results of a study that analyzed the effect of calorie restriction on lifespan in 41 different strains of mice, both male and female (2). They found that calorie restriction extends lifespan in a subset of strains, but actually shortens lifespan in an even larger subset. Below is a graph of the effect of calorie restriction on lifespan in the 41 strains. Positive numbers indicate that calorie restriction extended life, while negative numbers indicate that it shortened life ...
http://wholehealthsource.blogspot.no/2012/08/
Fig. 2 | Nature CommunicationsFig. 2 | Nature Communications
Impact of diet on development of lupus nephritis in NZM2410/J mice. a Representative image of NZM2410/J mouse exposed to Western diet (left) vs. a mouse fed with calorie-restricted diet (right) after 28 weeks of dietary intervention. b X-Y plot demonstrating the impact of diet and sex on body weight for caloric restriction (nfemales = 8, nmales = 10), for control diet (nfemales = 7, nmales = 10) and for western diet (nfemales = 9, nmales = 11). Error bars indicate means ± SEM. Data was analyzed using two-way ANOVA followed by Tukeys multiple comparison test, *p , 0.05, ***p , 0.001, n.s., not significant. All were evaluated in comparison to mice on control diet. ###p , 0.001 compared with mice on Western diet. c Step plot showing the onset of proteinuria in NZM2410/J mice for caloric restriction (n = 18), control (n = 17) and western (n = 20) diets. Mice fed Western diet developed proteinuria four weeks earlier (20.0 ± 3.0 weeks) in comparison to mice fed control diet (24.0 ± 2.7 weeks). ...
https://www.nature.com/articles/s41467-019-11952-w/figures/2?error=cookies_not_supported&code=38b61e8a-b2c5-448c-aa54-99f8ab5dba20
Practicing Family Medicine: The Late Clive McCay, Life Prolongation and Caloric RestrictionPracticing Family Medicine: The Late Clive McCay, Life Prolongation and Caloric Restriction
McCay used mature rats that were given the opportunity to grow and develop. He then restricted calories without restricting nutrients. This resulted in a significant prolongation of life. Since, this finding was replicated by many. Nowadays the fact that caloric restriction prolongs life does not need extra proof. Researchers are merely trying to to explain this phenomenon. As usual there is a focus on the physiology to try and develop drugs that will prolong life. I think we should just take this caloric intake life extension relationship as a fact and focus our effort on finding ways of applying it. McCay did that by designing McCays loaf, a nutrient dense loaf ...
http://practicingfamilymedicine.com/2013/01/the-late-clive-mccay-life-prolongation.html
The Impact of Exercise and Caloric Restriction on Cancer Recurrence in Mice - Lewis ChodoshThe Impact of Exercise and Caloric Restriction on Cancer Recurrence in Mice - Lewis Chodosh
Understanding the biological mechanisms that underlie the anti-tumorigenic effects of calorie restriction and physical activity will likely be essential for tra...
https://grantome.com/grant/NIH/U54-CA155850-02-6053
Fasting the microbiome to treat diabetes | Science Translational MedicineFasting the microbiome to treat diabetes | Science Translational Medicine
It is known that the microbiome has a role in diabetes pathophysiology, but more recently it has been suggested that the microbiome also moderates the efficacy of certain diabetes therapies. In an article by Beli et al., the authors demonstrate a potential link between the microbiome and the beneficial effects of dietary therapy. In contrast to chronic caloric restriction, intermittent fasting limits food intake to certain hours of the day, which is believed to benefit metabolic outcomes with relevance to diabetes.. Using the db/db mouse model of diabetes, the authors demonstrated that intermittent fasting improved survival and prevented the development of retinopathy. Each outcome was independent of glycated hemoglobin concentrations. So, the authors turned their attention to the intestinal microbiome to explain the benefit of intermittent fasting, Studies of fecal bacterial ecology demonstrated clear changes in phylogenetic distributions accompanied by differences in the mucosa, including ...
https://stm.sciencemag.org/content/10/441/eaat8529.full
Opposing effects of age and calorie restriction on molecular determina by Jason N. Peart, Louise S. See Hoe et al.Opposing effects of age and calorie restriction on molecular determina by Jason N. Peart, Louise S. See Hoe et al.
We test the hypothesis that moderate calorie restriction (CR) reverses negative influences of age on molecular determinants of myocardial stress resistance. Postischemic contractile dysfunction, cellular damage, and expression of regulators of autophagy/apoptosis and of prosurvival and prodeath kinases were assessed in myocardium from young adult (YA; 2- to 4-month-old) and middle-aged (MA; 12-month-old) mice, and MA mice subjected to 14 weeks of 40% CR (MA-CR). Ventricular dysfunction after 25%±2%), as was cell death indicated by troponin I (TnI) efflux (1,701±214 ng vs. 785±102 ng in YA). MA hearts exhibited 30% and 65% reductions in postischemic Beclin1 and Parkin, respectively, yet 50% lower proapoptotic Bax and 85% higher antiapoptotic Bcl2, increasing the Bcl2/Bax ratio. Age did not influence Akt or p38-mitogen-activated protein kinase (MAPK) expression; reduced expression of increasingly phosphorylated ribosomal protein S6 kinase (p70S6K), increased expression of dephosphorylated glycogen
http://epublications.bond.edu.au/hsm_pubs/523/
Effects of the Dietary Approaches to Stop Hypertension Diet Alone and in Combination With Exercise and Caloric Restriction on...Effects of the Dietary Approaches to Stop Hypertension Diet Alone and in Combination With Exercise and Caloric Restriction on...
Our findings demonstrate that adherence to the DASH diet alone, although sufficient to modify BP values,12 resulted in significant improvements in metabolic indices of cardiovascular risk only when accompanied by aerobic exercise and weight loss. In the DASH-WM group, participants lost an average of 19 pounds over 4 months and increased their aerobic capacity by 19%. Although both the DASH-A and DASH-WM groups achieved clinically meaningful reductions in BP and improvements in other cardiovascular biomarkers of risk, as described in our earlier publication,12 only DASH-WM participants demonstrated significant improvements in glucose tolerance and insulin sensitivity.. Although the DASH diet has been shown to reduce BP in controlled feeding studies7,8 and in studies of free-living individuals,9,12 the present study found that ENCORE participants who adhered to the DASH diet but did not exercise or lose weight achieved minimal improvements in glucose metabolism, insulin sensitivity, and lipids, ...
http://hyper.ahajournals.org/content/55/5/1199
Metabolic regulators in the mechanisms of caloric restriction - Rozalyn AndersonMetabolic regulators in the mechanisms of caloric restriction - Rozalyn Anderson
Caloric restriction (CR) delays the onset of aging and extends lifespan in diverse experimental organisms through an unknown mechanism. In mice, CR induces an e...
http://grantome.com/grant/NIH/R01-AG037000-03
Caloric restriction: bioenergetics, oxidative damage and aging (Summary) | Research groups | CABDCaloric restriction: bioenergetics, oxidative damage and aging (Summary) | Research groups | CABD
Research groupsCell biology and Biotechnology Caloric restriction: bioenergetics, oxidative damage and aging Dr Guillermo López ..
http://www.cabd.es/en-research_groups-24-64-caloric-restriction-bioenergetics-oxidative-damage-and-aging-summary.html
Long-term intermittent feeding, but not caloric restriction, leads toLong-term intermittent feeding, but not caloric restriction, leads to
Long-term intermittent feeding, but not caloric restriction, leads to redox imbalance, insulin receptor nitration, and glucose intolerance.
https://www.greenmedinfo.com/article/long-term-intermittent-feeding-not-caloric-restriction-leads-redox-imbalance-i
Difference Between Caloric Restriction and Intermittent FastingDifference Between Caloric Restriction and Intermittent Fasting
Many experts claim there is no difference between caloric restriction and intermittent fasting, but this is not true emotionally, or in the results achieved
http://livehealthyliveforever.com/caloric-restriction-fasting/
RFA-AG-13-008: Secondary Analyses of CALERIE Data Set and Stored Biospecimens to Address Research Questions Related to Effects...RFA-AG-13-008: Secondary Analyses of CALERIE Data Set and Stored Biospecimens to Address Research Questions Related to Effects...
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Secondary Analyses of CALERIE Data Set and Stored Biospecimens to Address Research Questions Related to Effects of Caloric Restriction in Humans and Adherence to Caloric Restriction Interventions (R01) RFA-AG-13-008. NIA
https://grants.nih.gov/grants/guide/rfa-files/RFA-AG-13-008.html
Yummy, Low Calorie Diet Food -- Plus Where to Buy!: Wii Fit, My New Exercise PartnerYummy, Low Calorie Diet Food -- Plus Where to Buy!: Wii Fit, My New Exercise Partner
Yummy, Low Calorie, Healthy Diet Food, for weight watchers (WW) diet, and people following the Points plan. Always explain where to buy yummy, low calorie, healthy, diet food.
http://www.yummydietfood.com/2008/06/wii-fitt-my-new-exercise-partner.html?showComment=1214065620000
Yummy, Low Calorie Diet Food -- Plus Where to Buy!: Benefits of Brown Rice vs. White RiceYummy, Low Calorie Diet Food -- Plus Where to Buy!: Benefits of Brown Rice vs. White Rice
Yummy, Low Calorie, Healthy Diet Food, for weight watchers (WW) diet, and people following the Points plan. Always explain where to buy yummy, low calorie, healthy, diet food.
http://www.yummydietfood.com/2010/10/benefits-of-brown-rice-vs-white-rice.html
Diabetes type 2 may reverse with a low calorie diet: StudyDiabetes type 2 may reverse with a low calorie diet: Study
Having type 2 diabetes, also called adult-onset or non-insulin dependent diabetes, has become very common in todays society. An estimated one in three Americans will develop type 2 diabetes by the year 2050, according to new projections by the Center for Disease Control and Prevention (CDC).. This growing trend is in direct correlation with the increasing rates of obesity in American citizens and has even extended to our younger population. This prevalence of type 2 diabetes has made health professionals around the globe concerned about the overall health of those affected, with mental well-being also in jeopardy.. According to a new report, type 2 diabetes goes into remission in many patients who undergo bariatric weight-loss surgery, a procedure that reduces the size of the stomach. This leads to less calorie intake, resulting in significant weight loss.. A team of researchers sought to find out exactly why this caloric restriction rapidly reverses type 2 diabetes.. ...
https://www.belmarrahealth.com/low-calorie-diets-may-reverse-type-2-diabetes-study/
In mice, calorie restriction reduces fat but increases fur | EurekAlert! Science NewsIn mice, calorie restriction reduces fat but increases fur | EurekAlert! Science News
Calorie restriction may help mice stay slim and live longer, but it also means less fat to keep their bodies warm. Researchers in Brazil have found that mouse skin responds to caloric restriction by stimulating fur growth, increasing blood flow, and altering cell metabolism to increase energy efficiency. The study, published Sept. 12 in Cell Reports, reveals that animals may use this as an evolutionary adaptation to stay warm -- and alive -- in limited food conditions.
https://www.eurekalert.org/pub_releases/2017-09/cp-imc090617.php
Low Fat, Low Cholesterol, Low Sugar, Low Calorie (diet): uses & side-effects | PatientsLikeMeLow Fat, Low Cholesterol, Low Sugar, Low Calorie (diet): uses & side-effects | PatientsLikeMe
Low Fat, Low Cholesterol, Low Sugar, Low Calorie (diet): Find the most comprehensive real-world treatment information on Low Fat, Low Cholesterol, Low Sugar, Low Calorie (diet) at PatientsLikeMe. 11 patients with fibromyalgia, multiple sclerosis, major depressive disorder, generalized anxiety disorder, systemic lupus erythematosus, diabetes type 2, post-traumatic stress disorder, rheumatoid arthritis, bipolar disorder, Parkinsons disease, panic disorder, high blood pressure (hypertension), myalgic encephalomyelitis/chronic fatigue syndrome, amyotrophic lateral sclerosis, persistent depressive disorder (dysthymia), epilepsy, migraine, hypothyroidism, osteoarthritis, attention deficit/hyperactivity disorder, bipolar II disorder, traumatic brain injury, asthma, high cholesterol (hypercholesterolemia), social anxiety disorder, irritable bowel syndrome, idiopathic pulmonary fibrosis, gastroesophageal reflux disease, bipolar I disorder or mild depression currently use Low Fat, Low Cholesterol, Low Sugar, Low
https://www.patientslikeme.com/treatment/low-fat-low-cholesterol-low-sugar-low-calorie
CiteSeerX - Citation Query Effects of calorie restriction on polymicrobial peritonitis induced by cecum ligation and puncture...CiteSeerX - Citation Query Effects of calorie restriction on polymicrobial peritonitis induced by cecum ligation and puncture...
CiteSeerX - Scientific documents that cite the following paper: Effects of calorie restriction on polymicrobial peritonitis induced by cecum ligation and puncture in young C57BL/6 mice,
http://citeseer.ist.psu.edu/showciting?cid=18154587
Caloric Restriction And Genomic Stability
Hunter Gathers Ate Ketogenic Diet A ketogenic diet makes your body use ketone bodies for fuel instead of sugar. How the Ketogenic Diet Weakens Cancer Cells. (such as for these hunter-gatherers). Yoga Lisa Dimmett Yoga with Lisa. 339 likes. Yoga Alliance UK certified teacher Keeping you up to date with my teaching schedule as well as sharing articles and yoga.. Nov 25, 2009. Background: Caloric restriction is recommended for the treatment of. preceded by a 4-wk weight-stability period (within ±2 kg), verified on a.. Issuu is a digital publishing platform that makes it simple to publish magazines, catalogs, newspapers, books, and more online. Easily share your publications and get.. Q: Researchers in [this segment] discuss how caloric restriction or the consumption of resveratrol could slow the onset of ailments associated with aging, such as diabetes or Alzheimers disease. Is it possible that the effects of these.. Mar 5, 2015. In conclusion, calorie restriction-triggered nitric oxide provides. ...
http://tuberoom.info/caloric-restriction-and-genomic-stability/
Dietary Modification: Low Calorie Diet | GreenMedInfo | TherapeuticDietary Modification: Low Calorie Diet | GreenMedInfo | Therapeutic
This topic has 3 study abstracts on Dietary Modification: Low Calorie Diet indicating that it may have therapeutic value in the treatment of Metabolic Syndrome X, Central Sleep Apnea, and Autoimmune Diseases
https://www.greenmedinfo.com/therapeutic-action/dietary-modification-low-calorie-diet
Studies of Sir2 and caloric restriction mimetic pathways in aging :: University of Southern California Dissertations and Theses
Increased dosage of Sir2, a conserved histone deacetylase, extends replicative life span in yeast, and possibly worms, and flies and protects mammals against certain diseases. Previous work in our lab has shown that it is the lack of Sir2 and not its overexpression that promotes resistance to different stresses and extends chronological lifespan when combined with calorie restriction (CR) and/or mutations in the Tor/Sch9 or Ras pathways in yeast. To identify genes and pathways that mimic the effects of CR on aging and cellular protection we explored the role of Sir2 in regulating stress response and examined the genetic interaction between Sir2 and stress resistance transcription factors, Msn2/4 and Gis1. Our results suggest that Msn2/4 and Gis1 are required for the enhanced stress resistance of sir2Δ mutant and the further extension of chronological lifespan of sir2Δ mutant under caloric restriction. In agreement with this result, the serine/theronine kinase Rim15, a positive regulator of ...
http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/221121/rec/2404
Studies of Sir2 and caloric restriction mimetic pathways in aging :: University of Southern California Dissertations and Theses
Increased dosage of Sir2, a conserved histone deacetylase, extends replicative life span in yeast, and possibly worms, and flies and protects mammals against certain diseases. Previous work in our lab has shown that it is the lack of Sir2 and not its overexpression that promotes resistance to different stresses and extends chronological lifespan when combined with calorie restriction (CR) and/or mutations in the Tor/Sch9 or Ras pathways in yeast. To identify genes and pathways that mimic the effects of CR on aging and cellular protection we explored the role of Sir2 in regulating stress response and examined the genetic interaction between Sir2 and stress resistance transcription factors, Msn2/4 and Gis1. Our results suggest that Msn2/4 and Gis1 are required for the enhanced stress resistance of sir2Δ mutant and the further extension of chronological lifespan of sir2Δ mutant under caloric restriction. In agreement with this result, the serine/theronine kinase Rim15, a positive regulator of ...
http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/221121/rec/3946
Niges Diet & Nutrition Blog: Very Low Calorie Diets (VLCDs)Niges Diet & Nutrition Blog: Very Low Calorie Diets (VLCDs)
b) High risk of developing Gallstones. Rapid weight loss results in an increase in the concentration of cholesterol in bile. This increases the risk factor for gallstones, something that women have a higher risk factor for than men. Theres an acronym FFFF for people who are at a high risk of developing gallstones. It stands for Female, Forty, Fat, Fair. What makes the situation even worse is that VLCDs are very low in fat. The gallbladder is a muscular bag which stores bile. When dietary fat is eaten, this stimulates the secretion of cholecystokinin, which then stimulates contraction of the gallbladder muscle, which expels bile from inside the gallbladder into the duodenum. The lower the fat content of a meal, the less the gallbladder contracts and gallbladder stasis can result with only 2g of fat per meal. See The role of gallbladder emptying in gallstone formation during diet-induced rapid weight loss. The problem with this study is that the two groups of subjects were not eating the same ...
https://nigeepoo.blogspot.com/2009/01/very-low-calorie-diets-vlcds.html
Very low calorie diets (VLCDs) as effective as a Lap Band? - The Mini-Gastric Bypass…Very low calorie diets (VLCDs) as effective as a Lap Band? - The Mini-Gastric Bypass…
Thirty women with a body mass index (BMI) | 27 kg/m2 were enrolled to a 4 weeks intervention with a VLCDPatients lost 35% ± 13% of the excess of weight in only 4 weeks.Significant improvements in triglycerides, total cholesterol and LDL cholesterol (Low Density Lipoproteins) were observed. Insulin resistance determined by Homeostasis model assessment (HOMA),…
https://clos.net/2012/04/19/very-low-calorie-diets-vlcds-as-effective-as-a-lap-band/
Uncoupling lifespan and healthspan in Caenorhabditis elegans longevity mutants | PNASUncoupling lifespan and healthspan in Caenorhabditis elegans longevity mutants | PNAS
Previously, the word healthspan has been used in many scientific contexts, but the definition has been ambiguous at best. Therefore, in this study, we focused on providing a conceptual framework of healthspan that can be easily verified in a laboratory setting using C. elegans. The current study makes no claim that the healthspan parameters tested cover all aspects of healthspan, nor does it make any assumptions that antiaging therapies that extend lifespan cannot coincide with an increase in healthspan. Rather, we highlight limitations of aging studies focused solely on lifespan extension.. Here we defined healthspan broadly by testing multiple assays as the animals aged. We tested wild type as our benchmark and then compared data from four long-lived mutants with wild-type health. From these data, we calculated and compared both the chronological number of days an animal is healthy vs. frail and the percent of the physiological lifespan the animal spends in each state (healthspan:gerospan ...
https://www.pnas.org/content/112/3/E277?ijkey=fc234f412d88dc5fdb7f319aea3d5ae32619ea35&keytype2=tf_ipsecsha
A LOW DOSE OF DIETARY RESVERATROL PARTIALLY MIMICS CALORIC RESTRICTION AND RETARDS AGING PARAMETERS IN MICEA LOW DOSE OF DIETARY RESVERATROL PARTIALLY MIMICS CALORIC RESTRICTION AND RETARDS AGING PARAMETERS IN MICE
This page contains the abstract- A Low Dose of Dietary Resveratrol Partially Mimics Caloric Restriction and Retards Aging Parameters in Mice http://www.chiro.org/nutrition/ABSTRACTS/A_Low_Dose_of_Dietary_Resveratrol.shtml
http://www.chiro.org/nutrition/ABSTRACTS/A_Low_Dose_of_Dietary_Resveratrol.shtml
Caloric restriction in Drosophila melanogaster. - pdf descargar
Caloric restriction in Drosophila melanogaster.. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
http://libros.duhnnae.com/2017/aug5/150247457051-Caloric-restriction-in-Drosophila-melanogaster.php
The Growth Hormone: Insulin-like Growth Factor 1 Axis Is a Mediator of Diet Restriction-induced Inhibition of Mononuclear Cell...The Growth Hormone: Insulin-like Growth Factor 1 Axis Is a Mediator of Diet Restriction-induced Inhibition of Mononuclear Cell...
Department of Nutrition [S. D. H., B. R. S., F. W. K.], University of North Carolina, Chapel Hill, North Carolina 27599, and National Institute of Environmental Health Sciences [S. D. H., J. E. F., F. W. K.], NIH, Research Triangle Park, North Carolina 27709 ...
https://cancerres.aacrjournals.org/content/53/12/2750.article-info
A Non-calorie-restricted Low-carbohydrate Diet is Effective as an Alternative Therapy for Patients with Type 2 Diabetes
Objective Although caloric restriction is a widely used intervention to reduce body weight and insulin resistance, many patients are unable to comply with such dietary therapy for long periods. The clinical effectiveness of low-carbohydrate diets was recently described in a position statement of Diabetes UK and a scientific review conducted by the American Diabetes Association. However, randomised trials of dietary interventions in Japanese patients with type 2 diabetes are scarce. Therefore, the aim of this study was to examine the effects of a non-calorie-restricted, low-carbohydrate diet in Japanese patients unable to adhere to a calorie-restricted diet ...
https://www.jstage.jst.go.jp/article/internalmedicine/53/1/53_53.0861/_article
Calorie restriction modulates Th-1 and Th-2 cytokine-induced immunoglobulin secretion in young and old C57BL/6 cultured...Calorie restriction modulates Th-1 and Th-2 cytokine-induced immunoglobulin secretion in young and old C57BL/6 cultured...
TY - JOUR. T1 - Calorie restriction modulates Th-1 and Th-2 cytokine-induced immunoglobulin secretion in young and old C57BL/6 cultured submandibular glands. AU - Jolly, C. A.. AU - Fernandez, R.. AU - Muthukumar, A. R.. AU - Fernandes, G.. PY - 1999/12/1. Y1 - 1999/12/1. N2 - Immunoglobulin production by the salivary gland plays an important role in oral and upper respiratory tract immunity. Age and/or disease may compromise salivary gland function. In order to gain insight into the role of calorie restriction (CR) on immunoglobulin (Ig) production, we determined the effect of ad libitum (AL) feeding and CR in young (3 months) and old (18-24 months) C57BL/6 mouse submandibular glands (SM). The SM tissues were fragmented and cultured in the absence (control) or presence of either Th-1 cytokines, such as interleukin-2 (IL-2) and interferon-γ (IFN-γ), or Th-2 cytokines, e.g. IL-4 and IL-5, for seven days. Culture supernatants were then analyzed for immunoglobulin A (IgA), IgM, and IgG(2α) ...
https://scholars.uthscsa.edu/en/publications/calorie-restriction-modulates-th-1-and-th-2-cytokine-induced-immu
Plus itPlus it
The effect of chronic (CCR) and intermittent (ICR) caloric restriction on serum adiponectin and leptin levels was investigated in relation to mammary tumorigenesis. 10-wks old MMTV-TGF-alpha female mice were assigned to ad libitum-fed (AL) (AIN-93M diet), ICR (3-wks 50% caloric restriction, AIN-93M-mod diet, 2x protein, fat, vitamins, and minerals followed by 3-wks 100% AL consumption of AIN-93M), and CCR (calorie and nutrient intake matched for each 6-wks ICR cycle, ~75% of AL) groups. Mice were sacrificed at 79 (end of restriction) or 82 (end of refeeding) wks of age. Serum was obtained in cycles 1, 3, 5, 8, 11 and terminal. Mammary tumor incidence was 71.0%, 35.4%, and 9.1% for AL, CCR and ICR mice, respectively. Serum adiponectin levels were similar among groups with no impact of either CCR or ICR. Serum leptin level rose in AL mice with increasing age but was significantly reduced by long-term CCR and ICR. The ICR protocol was also associated with an elevated adiponectin:leptin ratio. In ...
http://cancerpreventionresearch.aacrjournals.org/content/early/2011/01/19/1940-6207.CAPR-10-0140
Ghrelin-AMPK signaling mediates the neuroprotective effects of calorie restriction in Parkinsons Disease<...
TY - JOUR. T1 - Ghrelin-AMPK signaling mediates the neuroprotective effects of calorie restriction in Parkinsons Disease. AU - Bayliss, Jacqueline A.. AU - Lemus, Moyra B.. AU - Stark, Romana. AU - Santos, Vanessa V. AU - Thompson, Aiysha. AU - Rees, Daniel J.. AU - Galic, Sandra. AU - Elsworth, John D.. AU - Kemp, Bruce E.. AU - Davies, Jeffrey S.. AU - Andrews, Zane B.. PY - 2016/3/9. Y1 - 2016/3/9. N2 - Calorie restriction (CR) is neuroprotective in Parkinsons disease (PD) although the mechanisms are unknown. In this study we hypothesized that elevated ghrelin, a gut hormone with neuroprotective properties, during CR prevents neurodegeneration in an 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model of PD. CR attenuated the MPTP-induced loss of substantia nigra (SN) dopamine neurons and striatal dopamine turnover in ghrelin WT but not KO mice, demonstrating that ghrelin mediates CRs neuroprotective effect. CR elevated phosphorylated AMPK and ACC levels in the striatum of WT but not ...
https://research.monash.edu/en/publications/ghrelin-ampk-signaling-mediates-the-neuroprotective-effects-of-ca
Abstract P066: A Refined Carbohydrate Diet Attenuates Weight Loss in Insulin Resistant Individuals | CirculationAbstract P066: A Refined Carbohydrate Diet Attenuates Weight Loss in Insulin Resistant Individuals | Circulation
Introduction: Weight loss is attenuated in individuals with insulin resistance (IR) who follow a traditional high-carbohydrate, calorie-restricted diet. However, the type of carbohydrate may modulate this response. We studied the effects of whole grains vs. refined grains on weight loss in individuals with increased waist circumference (M: ,102 cm, F: ,88 cm) and at least 1 other metabolic syndrome characteristic.. Hypothesis: In a secondary analysis, we hypothesized that IR individuals (estimated by a triglyceride:high-density lipoprotein cholesterol ratio , 3.5) would lose more weight on a hypocaloric diet with whole grains vs. refined grains.. Methods: Overweight or obese (BMI 25-42 kg/m2) men and women (n=50) 35-55 yrs were randomized to a controlled-feeding diet with whole vs. refined grains for 12 weeks [6 weeks isocaloric then 6 weeks hypocaloric (∼500 kcal/d)].. Results: [All comparisons represented as IR mean±SEM vs. insulin sensitive (IS) mean±SEM, p-value)]. Compared to the IS ...
http://circ.ahajournals.org/content/125/Suppl_10/AP066
Expression of Longevity Genes in Response to Extended Fasting - Full Text View - ClinicalTrials.govExpression of Longevity Genes in Response to Extended Fasting - Full Text View - ClinicalTrials.gov
Coronary heart disease (CHD) is the largest contributor to morbidity and mortality in the Western world and is associated with high-calorie diet, high body mass, and a variety of other factors. CHD can lead to myocardial infarction (MI) and other embolic events. A growing body of evidence suggests that relatively low caloric intake in the diets of a variety of animals increases longevity and preliminary evidence among humans indicates that such caloric restriction reduces risk factors for CHD, including cholesterol levels, blood pressure, glucose, and obesity. Caloric restriction has also been shown to alter the expression of certain genes, especially the forkhead box (FOX) O and sirtuin (SIRT) genes whose over-expression has been shown to increase longevity in animal models. Extended avoidance of caloric intake, also called fasting or short-term starvation, has been shown to increase expression of the FOXA genes that have similar sequence and function as the FOXO genes and that have been shown ...
https://clinicaltrials.gov/ct2/show/NCT01059760
Lose Weight With HCG Ultra Diet Drops
Does the HCG diet work? Yes, it does and here is why. A low calorie diet used in combination with a hormone known as HCG can cause weight loss that is quick, easy and safe. It is estimated most dieters who participate in the HCG diet plan are able to lose ½ to 1 pound per day. The HCG weight loss plan is based on hypothalamus signaling. HCG combined with a low calorie diet (1,000 to 1,250 calories) notifies the body to signal the hypothalamus to release accumulated fat that has built up in the body. The fat release mechanism allows the body to be fueled by as many calories as necessary. The additional calories to help fuel your body is taken from the already stored fat. The already built up fat that has accumulated is in reality stored energy. That stored energy can be used as the body releases it, but the body does not give up fat easily. The body burns lean muscle first and when the muscle has been ravaged, stored fat is dragged kicking and screaming into the burn zone. HCG transposes the ...
http://www.hcgultradiet.com/whyhcg.htm
Mess Up Your Heart with Intermittent Fasting - Calorie Restriction - LONGECITYMess Up Your Heart with Intermittent Fasting - Calorie Restriction - LONGECITY
Mess Up Your Heart with Intermittent Fasting - posted in Calorie Restriction: As discussed many times before, and contrary to what is often said or implied, there is no specific benefit of alternate-day fasting (ADF)/every-other day feeding (EOD)/intermittent fasting (IF) on lifespan, long-term health, or aging, at the same Calorie intake. Feeding animals once, twice, or several times/day at the same net Calorie intake yields the same lifespan benefit: the limited effect on lifespan boils...
http://www.longecity.org/forum/topic/47354-mess-up-your-heart-with-intermittent-fasting/
MIT researcher sheds light on why cutting calories keeps organisms alive and healthier for longer | MIT NewsMIT researcher sheds light on why cutting calories keeps organisms alive and healthier for longer | MIT News
CAMBRIDGE, Mass. -- A Massachusetts of Technology researcher has helped yeast live longer by putting it on a strict diet.. His research team reports in the Sept. 22 issue of Science that an enzyme co-factor and a gene join forces with the reduction in calories to slow down aging.. The recent work of MIT biology professor Leonard Guarente may help explain the long-known fact that restricting calories to 70 percent of normal levels helps mice and other creatures live longer, healthier lives.. The billion-dollar question is: What is the mechanism through which this works?. Guarente, who studies the silenced information regulator (SIR2) gene and its apparent ability to slow the aging process, showed that in yeast, calorie restriction leads to an increase in the activity of the Sir2 protein (made by the SIR2 gene) required for genomic silencing. If the SIR2 gene is deleted or the co-factor levels in cells are depressed, the benefits of calorie restriction on longevity are not realized.. In yeast, age ...
http://news.mit.edu/2000/yeast
Low Calorie Food (12) | Art 2 Muse
Maddi, This is a good checklist as I like almost every part on it. I am glad to know in regards to the detrimental calories. However… they have a number of properties that make them an ideal meals, each for weight reduction and optimum health. Most those that adopt a excessive fiber low calorie meals diet as a part of a wholesome eating plan. Hopefully, you will not make the identical mistakes that I did and can understand why it is vital to eat a low calorie breakfast every single morning, it doesnt matter what! There is a limited list of unfavorable calorie foods, and limited methods to organize them, especially with out including extra energy.. There are many quick, straightforward and scrumptious low calorie breakfast concepts which you could make at house. However, its best to always check the labels of any cereal earlier than including it to your weight loss plan for this objective as a result of some are packed full of sugar. While eating them alone wont melt the fats off you, its ...
http://www.art2muse.com/low-calorie-food-12.html
Buy Optislim VLCD Meal Replacement Shake Chocolate 21x43g Sachets Online at ePharmacy®Buy Optislim VLCD Meal Replacement Shake Chocolate 21x43g Sachets Online at ePharmacy®
The Optislim VLCD (very low calorie diet) Chocolate is a nutritionally balanced total meal replacement designed for people requiring a practical weight management program. It contains all your daily nutritional requirements, including 25 vitamins and minerals when you use three sachets per day. Remember to maintain adequate fluid intake. We recommend that a minimum of 2 litres of water is consumed per day
https://www.epharmacy.com.au/buy/49471/optislim-vlcd-meal-replacement-shake-chocolate-21x43g-sachets?rcid=
Put on low calorie diet for fatty liver - Diet BlogPut on low calorie diet for fatty liver - Diet Blog
Fatty liver disease is characterized by the presence of abnormal amounts of fat in the liver, which is called steatosis. If you have fat in your liver but no other damage, you are thought to have nonalcoholic fatty liver disease NAFLD. If left untreated, inflammation and liver cell damage can occur, causing a disease called nonalcoholic steatohepatitis NASH. NASH is associated with cirrhosis, end-stage liver disease, and liver transplantation, and is often associated with cardiovascular-related diseases. Dietary changes inducing weight loss, adding nutrient-dense, antioxidant-packed foods, such as fruits and vegetables, can reverse or prevent the progression of the disease. Weight loss, particularly in the abdominal or adipose tissue, can help to reduce fat in the liver. Limiting refined carbohydrates, simple sugars, fried foods, processed foods, and foods high in saturated fat will also be important in treatment. Because fatty liver disease is often associated with obesity, insulin resistance, ...
https://kimbala.eu/put-on-low-calorie-diet-for-fatty-liver/
TV special shows diet reverses Type 2 Diabetes - Healthcanal.com : Healthcanal.comTV special shows diet reverses Type 2 Diabetes - Healthcanal.com : Healthcanal.com
The Food Hospital special: Extreme Diet Ward follows ground-breaking research by Professor Roy Taylor which found people could reverse their diabetes with an extreme low calorie diet alone.. Affecting two and half million people in the UK - and on the increase - Type 2 diabetes is a long-term condition caused by too much glucose, a type of sugar, in the blood. In the clinical trial published two years ago, 11 people reversed their diabetes by drastically cutting their food intake to just 600 calories a day for two months. And three months later, seven remained free of diabetes. For the Channel 4 programme, six women embarked on a low calorie diet with three of the following this extreme regime.. Professor Roy Taylor of Newcastle University who led the study and also works for The Newcastle-Upon-Tyne Hospitals NHS Foundation Trust said: To have people free of diabetes after years with the condition is remarkable - and all because of an eight week diet. This is a radical change in understanding ...
https://www.healthcanal.com/metabolic-problems/diabetes/41385-tv-special-shows-diet-reverses-type-2-diabetes.html
Micronutrient deficiency in obese subjects undergoing low calorie diet | Nutrition Journal | Full TextMicronutrient deficiency in obese subjects undergoing low calorie diet | Nutrition Journal | Full Text
The present study clearly confirms previous observations stating that obese individuals are characterized by micronutrient deficiencies [4, 6-8, 10-13]. The deficiencies are suggested by both low intake and low serum and intracellular levels as shown by our data.. The study demonstrates an insufficient dietary micronutrient supply of retinol, ß-carotene, vitamin D, vitamin E, vitamin C, folate, iron, and calcium in obese individuals. A highly significant difference compared to the reference population, both in men and women, was observed for ß-carotene, folate, vitamin C, and fiber - nutrients which are essentially found in fruits, vegetables and whole-grain products, thus pointing to an unbalanced diet leading to micronutrient deficiencies.. Evaluation of nutritional intake has some methodological weakness such as underreporting that limits the interpretation of dietary record data. The resulting error is possibly even more distinct in obese subjects [21-24]. However, underreporting ...
https://nutritionj.biomedcentral.com/articles/10.1186/1475-2891-11-34
Epigenetic regulation of caloric restriction in aging | BMC Medicine | Full TextEpigenetic regulation of caloric restriction in aging | BMC Medicine | Full Text
Several HDAC families have been identified, including class III NAD+-dependent HDACs such as Sirtuin 1. Sirtuin 1 (SIRT1) in mammals, and its orthologs in other species (Sirtuin 2 in yeast), deserves special attention due to its fundamental impact on aging regulation and CR-related lifespan extension [32-36]. The unusual enzymatic activity of SIRT1, which largely depends on NAD/NADH ratio, a key indicator for oxygen consumption, respiratory chain and metabolic rate, suggests that this protein is tightly connected to the metabolic state of cells.. The promising effect of SIRT1 in mediating CR and lifespan extension is supported by a diverse range of animal models, human subjects and even in vitro CR cellular systems [31-33, 35, 36, 81-85]. Activation of SIRT1 is frequently seen in different animal organs affected by CR, whereas inactivation of SIRT1 may lead to abolition of lifespan extension, suggesting a pivotal role of SIRT1 in lifespan regulation during CR. SIRT1 was initially discovered for ...
https://bmcmedicine.biomedcentral.com/articles/10.1186/1741-7015-9-98
does the mediterranean diet include pork low calorie diet plan for fast weight loss | can the mediterranean diet prevent...does the mediterranean diet include pork low calorie diet plan for fast weight loss | can the mediterranean diet prevent...
Also recognizing what worked 6 months to 1 year ago may not work today. Our bodies change over time and we have to adapt to those changes. So many factors affect your blood glucose levels; you will face hormonal changes, stress related changes, and your pancreas may not be working as well today as it did a year ago and we wouldnt expect it to. Just as the heart of an 18 year old person is much stronger than it will be at the age of 50 years of age, your pancreas function will decline with age with the normal aging process. Many of my patients throughout the years have came to me feeling so defeated because now they have to go on medication or insulin. They are so relieved to hear this may not be due to anything they have caused by overeating or weight gain, it may be just the unfortunate natural progression of diabetes. Until we discover cures for the different types of diabetes, this is what we face. ...
http://loss-of-weight-allegiance.com/chrissy-metz-weight-loss-what-kind-of-cheese-is-allowed-on-the-mediterranean-diet.html
Phase IIb One Year Efficacy and Safety Study of S-2367 in Obese Subjects With Initial 6-Week Low Calorie Diet - Full Text View ...Phase IIb One Year Efficacy and Safety Study of S-2367 in Obese Subjects With Initial 6-Week Low Calorie Diet - Full Text View ...
Females will be non-pregnant, non-lactating, and either postmenopausal for at least 1 year since last menstrual period, surgically sterile for at least 3 months prior to Visit 1, or agree to use an approved method of contraception. Some of the approved methods of contraception for females include a sterile (for at least 3 months prior to Visit 1) male sexual partner; use of oral, implantable, transdermal, or injectable oral contraceptives; or use of one of the following double-barrier methods: intrauterine device with spermicide, diaphragm with spermicide, cervical cap with spermicide, female condom with spermicide, or a male condom with spermicide by the male sexual ...
https://clinicaltrials.gov/show/NCT00748605
100-day Lactobacillus Gonjac Jelly low Calories & Diet Snack For Healthy Body Made In South Korea - JKCRAFT CO. - ecplaza.net100-day Lactobacillus Gonjac Jelly low Calories & Diet Snack For Healthy Body Made In South Korea - JKCRAFT CO. - ecplaza.net
* 100-day lactobacillus gonjac jelly - 10 billion lactic acid bacteria + fish collagen + double jelly - Lactobacillus platinum extracted from makgeolli. - Low molecular collagen peptide structure, absorption rate as high as 84% - Double jelly...
https://www.ecplaza.net/products/100-day-lactobacillus-gonjac-jelly-low_4513107
Clenbuterol Hydrochloride Explained | IronMag Bodybuilding BlogClenbuterol Hydrochloride Explained | IronMag Bodybuilding Blog
Dan Duchaine. So obviously, if people are using it unless they run out… there is still some perceived metabolic effect even after the initial hurricane of fat loss is over. Some of this might be a general percentage that the metabolism remains increased, or potentially even the anabolic/anti-catabolic effect of it. Most bodybuilders will use it for their last 12 weeks leading up to a contest, non-stop, and feel that it provides some benefit for the entire time (albeit less at the end). Interestingly, some rodent data exists that would suggest clenbuterol is more efficient on a calorie-restricted diet.. The anabolic effect of clenbuterol isnt like anabolic steroids, by any stretch of the imagination. Its noticeable, and with the fat loss that it provides, some amazing physique transformations are possible. Here, were talking about a few pounds of muscle gained, at most - but when you combine that with significant fat loss, the results can be fairly spectacular.. Its unknown exactly how ...
http://www.ironmagazine.com/2016/clenbuterol-hydrochloride-explained/
Keeping A Wholesome Balance PM360 | Innovative Health, Fitness, and Happiness StartupsKeeping A Wholesome Balance PM360 | Innovative Health, Fitness, and Happiness Startups
From yoga to HIIT, Barre to group cycle, whether you are a newbie or a sophisticated exerciser, add selection to your health program by attending one or more of our great collection of exercise lessons supplied every month. No matter challenges you may face, Residing Well Household Cares crew of house care professionals are here to help people remain active members of their communities, in addition to remain within the consolation of their residence. Any forum, occasion or exercise that makes use of movement, visible esthetics, yoga, dance and or music as a automobile for private and group enlightenment, bodily and emotional wellness and change.. Saved energy is also in body fats or adipose tissue. Although some analysis has urged that individuals who drink artificially sweetened sodas as part of a calorie-restricted diet do drop some pounds, different research have recommended that diet gentle drinks might even lead to weight gain. Whether or not you want to drop a few pounds, strengthen your ...
http://filmwritten.org/keeping-a-wholesome-balance-pm360.html
Fluoxetine Therapy in Obese Diabetic and Glucose Intolerant Patients | DIAL.pr - BOREALFluoxetine Therapy in Obese Diabetic and Glucose Intolerant Patients | DIAL.pr - BOREAL
A double-blind placebo-controlled trial was conducted, involving 97 obese diabetic and glucose intolerant patients receiving either 60 mg fluoxetine daily (47 patients) or a placebo (50 patients); a similar calorie-restricted diet was prescribed to all patients. Weight loss was significantly higher in the fluoxetine-treated patients, whose diabetic status improved. Drop-out rate was not significantly different for both groups of patients. ...
https://dial.uclouvain.be/pr/boreal/object/boreal:49877
About Ginny - Hypothyroid ChefAbout Ginny - Hypothyroid Chef
In 2011, two months after the birth of my son James, I was diagnosed with hypothyroidism. I thought my fatigue was normal for someone recovering from a c-section and breastfeeding a newborn. But my doctor informed me after some postpartum bloodwork that my thyroid function was low.. For the first few years I managed it with medication (Levothyroxine), and still do. But each year when I visited my doctor to run blood tests and see if my medication needed adjustment, I would tell her I didnt feel great, and wondered if my numbers were off, or if maybe the medication wasnt addressing all my symptoms. I felt tired most of the time, even upon waking. I couldnt lose weight even though I had been on a calorie-restricted diet for three years. I was sick a lot, sometimes for months at a time, doing round after round of antibiotics for things like ear infections, strep throat, tonsillitis, you name it. My brain felt foggy, I couldnt trust my memory, my joints ached. Looking back, its no wonder I ...
http://hypothyroidchef.com/about-ginny/
Progesterone Pregnancy ArchivesProgesterone Pregnancy Archives
HCG, or Human Chorionic Gonadotropin, is a hormone that is naturally produced by the placenta during pregnancy. This hormone goes a long way toward controlling the metabolic functioning of the pregnant woman. In addition, it helps to prevent the deterioration of the corpus luteum in the ovary. As a result, the corpus luteum is able to continue producing the progesterone that is necessary during pregnancy.. Since HCG is produced during pregnancy, medical professionals routinely check for elevated levels of HCG when testing for pregnancy. As a hormone that is associated with pregnancy, HCG is used to help treat women with fertility issues as well as other hormonal problems.. In addition to the effects that HCG has on hormones, it has also gained a great deal of popularity as a dietary aid. In order to assist men and women with weight loss, HCG is injected into the dieters muscle on a regular basis. When the injection is taken in conjunction with a very low calorie diet of 500 calories per day, ...
https://besthcgweightloss.com/tag/progesterone-pregnancy/
Notes from Dr. RW: Relationships between exercise, hunger and energy balanceNotes from Dr. RW: Relationships between exercise, hunger and energy balance
High-intensity exercise causes a short-term suppression of hunger of approximately 15 to 60 minutes. Although there is evidence for compensatory food consumption, it usually does not make up for the energy deficit created by exercise. The exception occurs when individuals consume or reward themselves with energy-dense foods or drink. Because people tend to eat the same volume of food each day, on days when they exercise, they will remain in an energy deficit. However, on sedentary days, a positive energy balance is likely if caloric restriction is not imposed, which could result in weight gain. Caloric restriction alone leads to loss of lean body mass, while the inclusion of exercise with an energy deficit helps conserve lean tissue. ...
http://doctorrw.blogspot.com/2015/07/relationships-between-exercise-hunger.html
Low carb protein meal:Salmon Pancake
Pickslim Salmon Blini is a delicious Keto meal flavour salmon compatible with your very low calorie diet with 113 kcal. Quick and easy to prepare for an easy to follow diet plan UK. You can now enjoy your weight loss plan with Pickslim diet food.
https://www.pickslim.com/en/p-low-carb-protein-meal-salmon-pancake-p140.html
mTOR and the Age-Related Decline in Stem Cell Activity - Fight Aging!mTOR and the Age-Related Decline in Stem Cell Activity - Fight Aging!
As a companion piece to an earlier post on the relationship between the mechanistic target of rapamycin (mTOR) gene and cellular senescence in aging, you might take a look at the research here that investigates the relationship between mTOR and the characteristic decline in stem cell activity that occurs with advancing age. In addition to the large body of research focused on insulin and growth hormone metabolism, work on mTOR is among the most active areas of study resulting from investigations of calorie restriction. The practice of calorie restriction has been shown to slow aging in near all species and lineages studied to date, so insofar as the response to calorie restriction is partially mediated through mTOR, we should expect mTOR to have some connection to most of the causes of aging. Unfortunately, calorie restriction has only a small effect on life span in our species. The research community doesnt yet know exactly how small, but it would be very surprising for it to be greater than ...
https://www.fightaging.org/?p=25028
RePub, Erasmus University Repository: Effects of Protein and Calorie Restriction on the Metabolism and Toxicity Profile of...RePub, Erasmus University Repository: Effects of Protein and Calorie Restriction on the Metabolism and Toxicity Profile of...
Preclinical data suggests that protein and calorie restriction (PCR) might improve treatment tolerability without impairing antitumor efficacy. Therefore, we have studied the influence of PCR on irinotecan pharmacokinetics and toxicity. In this crossover trial, patients with liver metastases of solid tumors were included and randomized to treatment with irinotecan preceded by 5 days of PCR (~ 30% caloric and ~ 70% protein restriction) during the first cycle and a second cycle preceded by a normal diet or vice versa. Pharmacokinetic blood sampling and biopsies of both healthy liver and liver metastases were performed. The primary end point was the relative difference in geometric means for the active metabolite SN-38 concentration in healthy liver analyzed by a linear mixed model. No significant differences were seen in irinotecan (+ 16.8%, P = 0.22) and SN-38 (+ 9.8%, P = 0.48) concentrations between PCR and normal diet in healthy liver, as well as in liver metastases (irinotecan: −38.8%, P = ...
https://repub.eur.nl/pub/132268
Longevity Archives - Gut ReactionsLongevity Archives - Gut Reactions
Intermittent fasting is one way to reduce body fat that is increasing in popularity because it is so simple to do. But there are other advantages besides weight loss.. ​It has long been known that dietary restriction increases lifespan.. Whether it takes the form of reduced calories, reducing one of the nutrient types (protein, fat, or carbohydrate), or fasting occasionally (not eating for a day or two), dietary restriction has been shown to have beneficial effects in all manner of organisms, such as yeast, worms, flies, mice, monkeys, and humans.​. ​When studying lifespan, it helps to work with organisms that have very short lifespans, where the effects of an intervention can be seen in the researchers lifetime. This is why much of the work has been done in short-lived species such as yeast, fruit flies, tiny worms,​ and mice. In these organisms, we see common mechanisms that dietary restriction triggers to increase lifespan, and we see those same mechanisms at work in longer lived ...
https://gutreactionscience.com/category/longevity/
PLOS ONE: A Low Dose of Dietary Resveratrol Partially Mimics Caloric Restriction and Retards Aging Parameters in MicePLOS ONE: A Low Dose of Dietary Resveratrol Partially Mimics Caloric Restriction and Retards Aging Parameters in Mice
Resveratrol in high doses has been shown to extend lifespan in some studies in invertebrates and to prevent early mortality in mice fed a high-fat diet. We fed mice from middle age (14-months) to old age (30-months) either a control diet, a low dose of resveratrol (4.9 mg kg−1 day−1), or a calorie restricted (CR) diet and examined genome-wide transcriptional profiles. We report a striking transcriptional overlap of CR and resveratrol in heart, skeletal muscle and brain. Both dietary interventions inhibit gene expression profiles associated with cardiac and skeletal muscle aging, and prevent age-related cardiac dysfunction. Dietary resveratrol also mimics the effects of CR in insulin mediated glucose uptake in muscle. Gene expression profiling suggests that both CR and resveratrol may retard some aspects of aging through alterations in chromatin structure and transcription. Resveratrol, at doses that can be readily achieved in humans, fulfills the definition of a dietary compound that mimics some
http://journals.plos.org/plosone/article/comment?id=info:doi/10.1371/annotation/5b0fe50c-1b9f-4021-aaf1-2e98e472de2e
Food Portion Control and Calorie Restriction Longevity and Health by Ralph Teller on 1VigorFood Portion Control and Calorie Restriction Longevity and Health by Ralph Teller on 1Vigor
How natural nutrition, food portion control, calorie restriction and eating essential nutrients and quality calories enhance longevity and optimal health.
http://www.1vigor.com/nutrition/nutrition.html
U-M researcher examines the cell s housekeeping habitsU-M researcher examines the cell s housekeeping habits
Autophagy may even provide a clue to the mythical fountain of youth. Autophagy activity is known to decrease with aging, and experiments in which autophagy was blocked in the C. elegans nematode worm resulted in dramatically shorter life spans for the 1 millimeter creatures. Conversely, more autophagy may prolong life. This fits with findings that caloric restriction can extend the life span in rats, since near-starvation triggers more autophagy as the cells recycle parts of themselves for fuel. Sustained autophagy may also increase longevity by protecting cells against free radical damage and mutations in DNA. This is becoming a very hot field, Klionsky said. We have a lot of really interesting questions to explore in autophagy ...
http://www.innovations-report.com/html/reports/life-sciences/report-35778.html
The Geeks | Flip The Food Pyramid
Simple caloric restriction (not IF) increases autophagic processes:. https://www.sciencedirect.com/science/article/pii/S2211124715014837. Its the caloric restriction that activates autophagy not the fasting.. You can do intermittent fasting 16+ hours a day but overeating calories during your eating window and not really ramp up autophagy much above baseline. Also fasting is not required to activate autophagy. Exercise also activates autophagy even in a fed state. In this study subjects got continuous glucose infusions while doing exercise and had great autophagy signaling that those doing a 36 hour fast.. https://www.physiology.org/doi/full/10.1152/japplphysiol.01116.2014. Also:. Exercise intensity more important than dietary supply for activating autophagy: https://www.fasebj.org/doi/full/10.1096/fj.14-267187. Fasting has some benefit. Its clearly a strong driver of autophagy (cellular regeneration), but then so are any cellular stressors such as resistance training or even consumption of ...
https://alldietsfail.com/the-geeks
Strategies for Preventing Age and Neurodegenerative Disease-associated by Vedad DelicStrategies for Preventing Age and Neurodegenerative Disease-associated by Vedad Delic
Mitochondrial dysfunction plays a pivotal role in the development of aging phenotypes and aging-associated neurodegenerative disorders, such as Alzheimers disease (AD), Parkinsons disease (PD) and Amyotrophic lateral sclerosis (ALS). Strategies that restore mitochondrial dysfunction may rescue the deficits of central metabolism in these disorders and improve cell survival. For example, we found that modulating the mTOR signaling pathway in a tissue culture model of aging-induced mitochondrial DNA mutation enhanced mitochondrial function as evidenced by increased oxygen consumption. Our previous melatonin studies also led us to hypothesize that caloric restriction and the hormone melatonin would reverse brain mitochondrial dysfunction in animal models of AD. Although caloric restriction did not improve mitochondrial function in a transgenic P301L tau model of AD, novel insight into the regulation of F0-F1 ATP synthase activity under CR was gained that may help explain the protective effects of CR in
http://scholarcommons.usf.edu/etd/5676/
Longevity Regulation by Drosophila Rpd3 Deacetylase and Caloric Restriction | ScienceLongevity Regulation by Drosophila Rpd3 Deacetylase and Caloric Restriction | Science
Thank you for your interest in spreading the word about Science.. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.. ...
https://science.sciencemag.org/content/298/5599/1745/tab-pdf
Pennington Biomedical Research CenterPennington Biomedical Research Center
A: The study was actually designed to find out why individuals do not lose weight, especially because they are burning more calories. The study examined all possibilities using a rigorous mathematical approach. The study established that vigorous exercise did result in increased food consumption. The study also determined that metabolism slowed during vigorous exercise if intake remained unchanged. Additionally, the study also established that lean (muscle) mass decreased less during aerobic exercise in comparison to diet restriction. We found that a larger fraction of weight gained (if one gained weight) during exercise is gained as lean mass. That is, if you lose weight through exercise, you lose mostly fat mass, and if you gain weight during exercise, you gain mostly lean mass. This is good news for all of us who want to lose fat.. 1. Martin, C.K., et al., Effect of calorie restriction on resting metabolic rate and spontaneous physical activity. Obesity (Silver Spring), 2007. 15(12): p. ...
http://pbrc.edu/research-and-faculty/calculators/weight-loss-predictor/faqs/
Comment on Antidepressants and caloric restriction, whats the connection?Comment on Antidepressants and caloric restriction, whats the connection?
Psychology is the study of behavior and mental state; psychological changes are changes in behavior and mental state. Yes, they are ultimately produced by some change in neurophysiology. My problem is that in popular use and apparently medical training (see MarkH of denialism blog and Jake of Pure Pedantry) the us of psychological is used in addiction and other mental disorders as a minimization technique. To suggest the problems are less real or somehow less serious or medically significant for patients. You seem to be saying that psychological just means the brain and behavior. So why do we never hear of cardiac addiction or gastrointestinal addiction or the like? There are both GI and cardiac symptoms of withdrawal and acute drug use, after all.. To use a philosophers trick, imagine that the same physiological changes took place, but did not alter behavior. Would we consider the effect to be of the same magnitude? If not, then there must be some component that does not lie within ...
https://blogs.nature.com/actionpotential/2007/12/antidepressants_and_caloric_re_1.html
Caloric restriction mimeticCaloric restriction mimetic
Dhahbi, JM; Mote PL; Fahy GM; Spindler SR (Nov 17, 2005). "Identification of potential caloric restriction mimetics by ... Calorie restriction mimetics (CRM), also known as energy restriction mimetics, are a hypothetical class of dietary supplements ... coenzyme Q10 and caloric restriction on life span and gene expression patterns in mice". Free Radic Biol Med. 36 (8): 1043-57. ... "Energy restriction and potential energy restriction mimetics". Nutrition Research Reviews. 28 (2): 100-120. doi:10.1017/ ...
https://en.wikipedia.org/wiki/Caloric_restriction_mimetic
DNA damage theory of agingDNA damage theory of aging
In rodents, caloric restriction slows aging and extends lifespan. At least 4 studies have shown that caloric restriction ... Protective effects of caloric restriction". Exp Gerontol. 40 (3): 181-8. doi:10.1016/j.exger.2004.11.002. PMID 15763395. S2CID ... One of these studies showed that caloric restriction reduced accumulation of 8-OHdG with age in rat brain, heart and skeletal ... showed that dietary restriction reduced accumulation of 8-OHdG with age in rat brain, heart, skeletal muscle, and liver. Thus ...
https://en.wikipedia.org/wiki/DNA_damage_theory_of_aging
Disposable soma theory of agingDisposable soma theory of aging
In additional to differential partitioning of energy allocation during caloric restriction, less caloric intake would result in ... This theory is supported by multiple studies, which show that caloric restriction typically results in impaired fertility, but ... Activated in times of caloric restriction, autophagy is a process that prevents cellular damage through clearance and recycling ... Cantó C, Auwerx J (2009). "Caloric restriction, SIRT1 and longevity". Trends Endocrinol Metab. 20 (7): 325-331. doi:10.1016/j. ...
https://en.wikipedia.org/wiki/Disposable_soma_theory_of_aging
AgeingAgeing
DNA oxidation and caloric restriction: Caloric restriction reduces 8-OH-dG DNA damage in organs of ageing rats and mice. Thus, ... Caloric restriction leads to longer lifespans in various species, an effect that is unclear, but probably mediated by the ... In his book How and Why We Age, Hayflick says that caloric restriction may not be effective in humans, citing data from the ... Autophagy is enhanced in obese mice by caloric restriction, exercise, and a low fat diet (but in these mice is evidently not ...
https://en.wikipedia.org/wiki/Ageing
Lloyd DemetriusLloyd Demetrius
Demetrius, L. (2004). "Caloric Restriction, Metabolic Rate, and Entropy". The Journals of Gerontology Series A: Biological ... Quantum Aspects of Life Caloric restriction Longevity "Lloyd Demetrius". Hwpi.harvard.edu. Demetrius, Lloyd (September 1, 2013 ...
https://en.wikipedia.org/wiki/Lloyd_Demetrius
Psychological therapies for dementiaPsychological therapies for dementia
Li Y, Daniel M, Tollefsbol TO (August 2011). "Epigenetic regulation of caloric restriction in aging". BMC Medicine. 9 (1): 98. ...
https://en.wikipedia.org/wiki/Psychological_therapies_for_dementia
Calorie restrictionCalorie restriction
... (caloric restriction or energy restriction) is a dietary regimen that reduces intake of energy from caloric ... evidence that caloric restriction could prevent age-related disease in humans is still emerging. A calorie restriction study ... In other words, caloric restriction places the organism in a defensive state so that it can survive adversity. As of 2019[ ... Which protocols of and combinations (e.g. see caloric restriction mimetic and AMPK) with DR are effective or most effective in ...
https://en.wikipedia.org/wiki/Calorie_restriction
Healthy dietHealthy diet
... dietary restriction such as caloric restriction is considered to be potentially healthy to include in eating patterns in ... Hofer SJ, Davinelli S, Bergmann M, Scapagnini G, Madeo F (2021). "Caloric Restriction Mimetics in Nutrition and Clinical Trials ... March 2021). "Recent advances in the field of caloric restriction mimetics and anti-aging molecules". Ageing Research Reviews. ... such as not having a fat-intake that is too low and not having a prolonged caloric surplus or caloric deficit that is too large ...
https://en.wikipedia.org/wiki/Healthy_diet
Rozalyn AndersonRozalyn Anderson
2009). "Caloric restriction delays disease onset and mortality in rhesus monkeys". Science. 325 (5937): 201-4. Bibcode:2009Sci ... Anderson worked as part of the University of Wisconsin team that demonstrated that caloric restriction has a beneficial effect ... She studies aging and caloric restriction in primates. Anderson received her bachelor's degree from Trinity College, Dublin and ... Anderson, R. M.; Shanmuganayagam, D.; Weindruch, R. (2009). "Caloric Restriction and Aging: Studies in Mice and Monkeys". ...
https://en.wikipedia.org/wiki/Rozalyn_Anderson
Leanne RedmanLeanne Redman
doi:10.1038/d41586-018-03431-x. Kwon, Diana (March 26, 2018). "Caloric Restriction Slows Signs of Aging in Humans". The ...
https://en.wikipedia.org/wiki/Leanne_Redman
Anti-aging movementAnti-aging movement
Caloric restriction is a phenomenon introduced in anti-aging techniques which focuses on depletion of calories and taking the ... Bj, Willcox; Dc, Willcox; H, Todoriki; A, Fujiyoshi; K, Yano; Q, He; Jd, Curb; M, Suzuki (October 2007). "Caloric Restriction, ... Sohal, Rajindar S.; Forster, Michael J. (2014-08-01). "Caloric restriction and the aging process: a critique". Free Radical ... Calorie restriction (CR) refers to a dietary restriction that focuses on less calorie intake to increase longevity and reduce ...
https://en.wikipedia.org/wiki/Anti-aging_movement
Life extensionLife extension
During periods of caloric restriction, higher protein intakes "may be required to maximize muscle retention in lean, resistance ... Which protocols of and combinations (e.g. see caloric restriction mimetic and AMPK) with DR are effective or most effective in ... In humans the long-term health effects of moderate caloric restriction with sufficient nutrients are unknown. According to two ... April 2001). "Aging and caloric restriction in nonhuman primates: behavioral and in vivo brain imaging studies". Annals of the ...
https://en.wikipedia.org/wiki/Life_extension
Anti-obesity medicationAnti-obesity medication
Such nutraceuticals exert effects similar to caloric restriction. However, more studies are needed and some CRMs may not have ... The main treatment modalities for overweight and individuals with obesity remain dieting (healthy diet and caloric restriction ... Accumulating evidence demonstrated anti-obesity impact of caloric restriction mimetics (CRMs) like spermidine. ... "The Potential of Resveratrol to Act as a Caloric Restriction Mimetic Appears to Be Limited: Insights from Studies in Mice". ...
https://en.wikipedia.org/wiki/Anti-obesity_medication
CRON-dietCRON-diet
ISBN 978-90-481-3998-9. Anderson, R. M.; Shanmuganayagam, D.; Weindruch, R. (2009). "Caloric Restriction and Aging: Studies in ... The CRON-diet involves calorie restriction in the hope that the practice will improve health and retard aging, while still ... There is experimental evidence that calorie restriction can slow biological aging in mammals such as mice and monkeys, but the ... The review observed that one outcome had been the development of calorie restriction mimetic drugs which would be tested in ...
https://en.wikipedia.org/wiki/CRON-diet
Energy homeostasisEnergy homeostasis
Human energy requirements (Rome, 17-24 October 2001) Anderson RM, Shanmuganayagam D, Weindruch R (2009). "Caloric restriction ... "Metabolic shifts due to long-term caloric restriction revealed in nonhuman primates". Exp. Gerontol. 44 (5): 356-62. doi: ... Calorie restriction may be viewed as attaining energy balance at a lower intake and expenditure, and is, in this sense, not ... Yet, there are currently ongoing studies to show if calorie restriction to below normal values have beneficial effects, and ...
https://en.wikipedia.org/wiki/Energy_homeostasis
Diet and cancerDiet and cancer
Potential complementary or preventive options under investigation include periods of caloric restriction and AMPK agonists ( ... Meynet, Ophélie; Ricci, Jean-Ehrland (August 2014). "Caloric restriction and cancer: molecular mechanisms and clinical ... According to a 2012 review, the effect of methionine restriction on cancer has yet to be studied directly in humans and "there ... Cavuoto P, Fenech MF (October 2012). "A review of methionine dependency and the role of methionine restriction in cancer growth ...
https://en.wikipedia.org/wiki/Diet_and_cancer
January-March 2022 in scienceJanuary-March 2022 in science
Results from the first controlled trial of caloric restriction in healthy non-obese humans, CALERIE, are published, confirming ... "Caloric restriction in humans reveals immunometabolic regulators of health span". Science. 375 (6581): 671-677. Bibcode:2022Sci ... "Calorie restriction trial reveals key factors in extending human health". Science Daily. 10 February 2022. Retrieved 23 ... "Calorie restriction rewires metabolism, immunity for longer health span". Science Daily. 10 February 2022. Retrieved 23 ...
https://en.wikipedia.org/wiki/January–March_2022_in_science
Timeline of senescence researchTimeline of senescence research
A study demonstrates that a 30% caloric restriction extended life spans of male C57BL/6J mice by 10% but when combined with ... de Grey AD (15 June 2004). "The unfortunate influence of the weather on the rate of ageing: why human caloric restriction or ... Results from the first controlled trial of caloric restriction in healthy non-obese humans, CALERIE, are published, confirming ... "Caloric restriction in humans reveals immunometabolic regulators of health span". Science. 375 (6581): 671-677. Bibcode:2022Sci ...
https://en.wikipedia.org/wiki/Timeline_of_senescence_research
MTORC1MTORC1
July 2009). "Caloric restriction delays disease onset and mortality in rhesus monkeys". Science. 325 (5937): 201-204. Bibcode: ... Dietary restriction has been shown to significantly increase lifespan in the human model of Rhesus monkeys as well as protect ... Thus dietary restriction inhibits mTORC1 signaling through both upstream pathways of mTORC that converge on the lysosome. ... Blagosklonny MV (February 2010). "Calorie restriction: decelerating mTOR-driven aging from cells to organisms (including humans ...
https://en.wikipedia.org/wiki/MTORC1
Clive McCayClive McCay
He is best known for his work in proving that caloric restriction increases the life span of rats, which is seen as seminal in ... McDonald, Roger B.; Ramsey, Jon J. (July 2010). "Honoring Clive McCay and 75 years of caloric restriction research". Journal of ... Scientists are still trying to understand the connection between caloric restriction and longevity. Following his discovery ...
https://en.wikipedia.org/wiki/Clive_McCay
Nicotinamide adenine dinucleotideNicotinamide adenine dinucleotide
Wood JG, Rogina B, Lavu S, Howitz K, Helfand SL, Tatar M, Sinclair D (2004). "Sirtuin activators mimic caloric restriction and ...
https://en.wikipedia.org/wiki/Nicotinamide_adenine_dinucleotide
Biosphere 2Biosphere 2
Redman, L. M; Ravussin, E (2011). "Caloric Restriction in Humans: Impact on Physiological, Psychological, and Behavioral ... despite the selective restriction in calories and marked weight loss, all crew members remained in excellent health and ... 3 (3): 9. Walford, R. L; Mock, D; Verdery, R; MacCallum, T (2002). "Calorie restriction in biosphere 2: Alterations in ... health improvements with the high nutrient and low caloric diet the crew followed, and insights into the self-organization of ...
https://en.wikipedia.org/wiki/Biosphere_2
AutophagyAutophagy
Yessenkyzy A, Saliev T, Zhanaliyeva M, Nurgozhin T (2020). "Polyphenols as Caloric-Restriction Mimetics and Autophagy Inducers ... function provides a link between sirtuin expression and the cellular response to limited nutrients due to caloric restriction. ...
https://en.wikipedia.org/wiki/Autophagy
Metabolic flexibilityMetabolic flexibility
Veech RL, Bradshaw PC, King MT (2017). "Ketone bodies mimic the life span extending properties of caloric restriction". IUBMB ...
https://en.wikipedia.org/wiki/Metabolic_flexibility
Senescence-associated secretory phenotypeSenescence-associated secretory phenotype
Yessenkyzy A, Saliev T, Zhanaliyeva M, Nurgozhin T (2020). "Polyphenols as Caloric-Restriction Mimetics and Autophagy Inducers ...
https://en.wikipedia.org/wiki/Senescence-associated_secretory_phenotype
Brown adipose tissueBrown adipose tissue
"Sirt1 enhances skeletal muscle insulin sensitivity in mice during caloric restriction". The Journal of Clinical Investigation. ...
https://en.wikipedia.org/wiki/Brown_adipose_tissue
MAPKAPK2MAPKAPK2
May 2020). "Polyphenols as Caloric-Restriction Mimetics and Autophagy Inducers in Aging Research". Nutrients. 12 (5): 1344. doi ...
https://en.wikipedia.org/wiki/MAPKAPK2
Pyruvate dehydrogenasePyruvate dehydrogenase
Veech RL, Bradshaw PC, King MT (2017). "Ketone bodies mimic the life span extending properties of caloric restriction". IUBMB ...
https://en.wikipedia.org/wiki/Pyruvate_dehydrogenase
Sirtuin 1Sirtuin 1
Furthermore, removing the Sir2 gene eliminates the life-extending effect of caloric restriction. Experiments in the nematode ... EntrezGene 23411 Human Sirt1 Yessenkyzy A, Saliev T, Zhanaliyeva M, Nurgozhin T (2020). "Polyphenols as Caloric-Restriction ... function provides a link between sirtuin expression and the cellular response to limited nutrients due to caloric restriction. ... calorie restriction can substantially prolong reproductive lifespan in yeast even in the absence of Sir2. In organisms more ...
https://en.wikipedia.org/wiki/Sirtuin_1
MTORMTOR
It is hypothesized that some dietary regimes, like caloric restriction and methionine restriction, cause lifespan extension by ... Yessenkyzy A, Saliev T, Zhanaliyeva M, Nurgozhin T (2020). "Polyphenols as Caloric-Restriction Mimetics and Autophagy Inducers ... Calorie restriction and methionine restriction may act in part by limiting levels of essential amino acids including leucine ... "Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction". ...
https://en.wikipedia.org/wiki/MTOR
Food desertFood desert
Regardless of daily caloric intake, those who do not eat foods that are rich in vitamins and nutrients are susceptible to ... For many people who have health restrictions and food allergies, the effects of food deserts are further compounded. The time ...
https://en.wikipedia.org/wiki/Food_desert
Medieval cuisineMedieval cuisine
The overall caloric intake is subject to some debate. One typical estimate is that an adult peasant male needed 2,900 calories ... Since the sick were exempt from fasting, there often evolved the notion that fasting restrictions only applied to the main ... The caloric content and structure of medieval diet varied over time, from region to region, and between classes. However, for ... This caloric structure partly reflected the high-class status of late Medieval monasteries in England, and partly that of ...
https://en.wikipedia.org/wiki/Medieval_cuisine
Low-alcohol beerLow-alcohol beer
Beer below or equaling 2.25% ABV (lättöl) is not legally subject to age restrictions; however, some stores voluntarily opt out ... Light beers are beers with reduced caloric content compared to regular beer, and typically also have a lower alcoholic content ... and it can be purchased without any age restriction. In New Jersey, the law governs only beverages of at least 0.5% ABV. In ... since both carbohydrates and alcohol contribute to the caloric content of beer. Light beers are marketed primarily to drinkers ...
https://en.wikipedia.org/wiki/Low-alcohol_beer
Sándor J. KovácsSándor J. Kovács
The Effects of Caloric Restriction- and Exercise-Induced Weight Loss on Left Ventricular Diastolic Function. American Journal ...
https://en.wikipedia.org/wiki/Sándor_J._Kovács
Caloric deficitCaloric deficit
"Metabolic and Behavioral Compensations in Response to Caloric Restriction: Implications for the Maintenance of Weight Loss". ... "CALORIC NEEDS". www.utmb.edu. Archived from the original on 31 May 2016. Retrieved 2015-07-09. Dulloo, A. G.; Geissler, C. A.; ... There are also some substances, including caffeine, which can create a small (3-5%) increase in caloric expenditure, via a ... Increased output is created by increasing physical activity, from increased caloric requirements necessary to heal an injury, ...
https://en.wikipedia.org/wiki/Caloric_deficit
VagotomyVagotomy
Attempts at caloric restriction or pharmacotherapy with adrenergic or serotonergic agents have previously met with little or ... "VMH dysfunction promotes excessive caloric intake and decreased caloric expenditure, leading to continuous and unrelenting ... Animals with lesioned VMH will gain weight even in the face of severe restrictions imposed on their food intake, because they ...
https://en.wikipedia.org/wiki/Vagotomy
OlestraOlestra
Jandacek RJ, Anderson N, Liu M, Zheng S, Tso QY (February 2005). "Effects of yo-yo diet, caloric restriction, and olestra on ...
https://en.wikipedia.org/wiki/Olestra
Index of physics articles (C)Index of physics articles (C)
Space Caldeira-Leggett model Calefaction Callan-Symanzik equation Callendar-Van Dusen equation Calogero conjecture Caloric ... database Crystallographic defect Crystallographic group Crystallographic point group Crystallographic restriction theorem ...
https://en.wikipedia.org/wiki/Index_of_physics_articles_(C)
Leonard P. GuarenteLeonard P. Guarente
That same year, David Sinclair joined the Guarente lab, and they developed the hypothesis that caloric restriction slows aging ... Rogina, B.; S.L. Helfand (2004). "Sir2 mediates longevity in the fly through a pathway related to calorie restriction". Proc ... Moreover, scientists in Guarente laboratory determined that SIR2 is necessary for longevity extension by calorie restriction. ... 2007). "SIRT1 transgenic mice show phenotypes resembling calorie restriction". Aging Cell. 6 (6): 759-67. doi:10.1111/j.1474- ...
https://en.wikipedia.org/wiki/Leonard_P._Guarente
Healthcare in CubaHealthcare in Cuba
Economic constraints and restrictions on medicines have forced the Cuban health system to incorporate alternative and herbal ... have been related to sustained population-wide weight loss as a result of increased physical activity and reduced caloric ... During the 1990s the ongoing United States embargo against Cuba caused problems due to restrictions on the export of medicines ... The Cuban delegation concluded that restrictions on importing medical products were "so extensive that they make such imports ...
https://en.wikipedia.org/wiki/Healthcare_in_Cuba
Food-entrainable oscillatorFood-entrainable oscillator
Time-restricted feeding is when all of the caloric intake for a day is limited to certain times of the day. A frequent ... 350 transcripts during food restriction. These anticipatory food mechanisms point to an interconnectedness of peripheral ...
https://en.wikipedia.org/wiki/Food-entrainable_oscillator
MetforminMetformin
"FDA requires removal of certain restrictions on the diabetes drug Avandia". U.S. Food and Drug Administration (FDA) (Press ... Metformin also exerts an anorexiant effect in most people, decreasing caloric intake. Metformin decreases gluconeogenesis ( ... In November 2013, the FDA lifted its earlier restrictions on rosiglitazone after reviewing the results of the 2009 RECORD ... 24 May 2011.[permanent dead link] "Glaxo's Avandia Cleared From Sales Restrictions by FDA". Bloomberg. Archived from the ...
https://en.wikipedia.org/wiki/Metformin
Gastric bypass surgeryGastric bypass surgery
Energy levels in the period following the surgery can be low, both due to the restriction of food intake and negative changes ... Some assume the cause of regaining weight must be the patient's fault, e.g. eating between meals with high-caloric snack foods ... This is caused by a number of factors, including a restriction on protein intake, a resulting loss in muscle mass and decline ... For example, it is still widely perceived that gastric bypass works by mechanical means, i.e. food restriction and/or ...
https://en.wikipedia.org/wiki/Gastric_bypass_surgery
School mealSchool meal
Not every meal has to meet precise caloric guidelines......Central government officials say they have ultimate authority to ... barring dietary restrictions) is the same for every student. Children in most districts cannot bring their own meals to school ...
https://en.wikipedia.org/wiki/School_meal
Bengal famine of 1943Bengal famine of 1943
This easing of restrictions plus the ban on exports created about four months of relative price stability. In mid-October, ... which often provided barely a survival-level caloric intake, was sometimes unfit for consumption - decayed or contaminated with ...
https://en.wikipedia.org/wiki/Bengal_famine_of_1943
Other LossesOther Losses
He said, "Our responsibility for the proper use of relief supplies placed in our care is incompatible with a restriction to the ... that Clark raised the caloric intake levels in response to a report critical of the treatment of liberated Jews that had just ... Other Losses fails to cite JCS 1067, the primary restriction on food importation, even once in its notes. Villa also states ... including restrictions on Red Cross food deliveries, and other means. It states that Eisenhower purposefully starved German ...
https://en.wikipedia.org/wiki/Other_Losses
InhalantInhalant
However, many US states and Canadian cities have placed restrictions on the sale of some solvent-containing products to minors ... Although inhaled alcohol does reduce the caloric content, the savings are minimal. After expressed safety and health concerns, ...
https://en.wikipedia.org/wiki/Inhalant
Beer in CanadaBeer in Canada
Other sources also acknowledge these two, plus Miller Lite as best sellers in many provinces." The caloric content can vary ... could not stand up with a drink and had other restrictions. Many beer parlours were segregated by sex, and had a men's only ...
https://en.wikipedia.org/wiki/Beer_in_Canada
DNA repairDNA repair
... an activity that is especially promoted under conditions of caloric restriction. Caloric restriction has been closely linked to ... Caloric restriction reproducibly results in extended lifespan in a variety of organisms, likely via nutrient sensing pathways ... Cabelof DC, Yanamadala S, Raffoul JJ, Guo Z, Soofi A, Heydari AR (March 2003). "Caloric restriction promotes genomic stability ... the behavior of many genes known to be involved in DNA repair is altered under conditions of caloric restriction. Several ...
https://en.wikipedia.org/wiki/DNA_repair
SodaStreamSodaStream
The workers were not allowed to bring their own food into the plant due to Jewish dietary restrictions being enforced. ... less caloric and water based beverages" as opposed to traditional carbonated soft drinks. Some 20% of households in Sweden ...
https://en.wikipedia.org/wiki/SodaStream
Transient hyperammonemia of the newbornTransient hyperammonemia of the newborn
THAN can also be treated by avoiding amino acids in TPN or total parenteral nutrition or by giving a high caloric diet to limit ... Since transamination of proteins is a leading producer of ammonia, protein restriction may be recommended as a therapy to ...
https://en.wikipedia.org/wiki/Transient_hyperammonemia_of_the_newborn
LeptinLeptin
... caloric restriction, and body fat levels. While it is well-established that leptin is involved in the regulation of the ... When high caloric intake overtaxes the ability of fat cells to grow larger or increase in number in step with caloric intake, ... effects of caloric restriction and weight loss". The Journal of Clinical Endocrinology and Metabolism. 83 (1): 214-218. doi: ... The insulin increase in response to the caloric load provokes a dose-dependent rise in leptin, an effect potentiated by high ...
https://en.wikipedia.org/wiki/Leptin
AnovulationAnovulation
Studies show a reduction in weight as little of 5% by caloric restriction and increased physical activity can re-establish ... dysfunction due to increased energy requirements without their needs being met calorically and severely reduced caloric intake ...
https://en.wikipedia.org/wiki/Anovulation
DietingDieting
A meta-analysis of 16 trials of 2-12 months' duration found that low-fat diets (without intentional restriction of caloric ... Some evidence suggests that intermittent restriction of caloric intake has no weight-loss advantages over continuous calorie ... These caloric intake values vary depending on additional factors, such as age and weight. Very low calorie diets provide 200- ... This type of diet is based on the restriction of specific foods or food groups. Examples include gluten-free, Paleo, plant- ...
https://en.wikipedia.org/wiki/Dieting
One Million PlanOne Million Plan
The plan was elaborated with great detail, even calculating the caloric value of the meals that were to be prepared in the ... The ongoing immigration restrictions of the British White Paper of 1939 meant that such a plan was not able to be put into ... the immigration restrictions to the country were removed, making it possible to implement the policy changes relating to large- ... not as an operative plan since the British immigration restrictions were still in place at the time, but as a political plan to ...
https://en.wikipedia.org/wiki/One_Million_Plan
Sleeping habits predict the magnitude of fat loss in adults exposed to moderate caloric restrictionSleeping habits predict the magnitude of fat loss in adults exposed to moderate caloric restriction
... Obes Facts. 2012;5(4):561-6 ... sleep quantity and quality at baseline predict the magnitude of fat loss in adults subjected to moderate caloric restriction. ...
https://pubmed.ncbi.nlm.nih.gov/22854682/?dopt=Abstract
Is Caloric Restriction Good For You? | NutritionFacts.orgIs Caloric Restriction Good For You? | NutritionFacts.org
Animal studies suggest caloric restriction is beneficial, but what does some of the first human data show? ... Republishing "Is Caloric Restriction Good For You?". × Terms You may republish this material online or in print under our ... Is Caloric Restriction Good For You?. Michael Greger M.D. FACLM · October 21, 2009 · Volume 3 ... Is Caloric Restriction Good For You?. License Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). ...
https://nutritionfacts.org/video/is-caloric-restriction-good-for-you/
Exercise, bone mass and caloric restrictionExercise, bone mass and caloric restriction
... training can preserve and even significantly bolster bone mass in the hip and femoral neck of individuals under caloric ... Individuals decreased their caloric intake by 250 to 1500 kcal/day, compared to their pre-restriction total energy intake. ... can preserve and even significantly bolster bone mass in the hip and femoral neck of individuals under caloric restriction, ... can preserve and even significantly bolster bone mass in the hip and femoral neck of individuals under caloric restriction, ...
https://www.contemporaryobgyn.net/view/exercise-bone-mass-and-caloric-restriction
Autologous fecal transplantation from a lean state potentiates caloric restriction effects on body weight and adiposity in...Autologous fecal transplantation from a lean state potentiates caloric restriction effects on body weight and adiposity in...
... potentiates the effects of a moderate caloric restriction (CR) in high-fat diet (HFD)-induced obese mice. Mice were randomized ... Effects of caloric restriction (A), heterologous FMT (B) and autologous FMT (C) on Observed Species, Chao-1 and Simpson indexes ... control). A moderate caloric restriction was able to partially impair such increase (p , 0.05 vs. control). FT-A mice showed a ... control) was lower in those animals under a moderate caloric restriction for 6 weeks (p , 0.01 vs. control and vs. HFD). This ...
https://www.nature.com/articles/s41598-020-64961-x?error=cookies_not_supported&code=51c6f8e7-ca39-4555-8900-9cc3fb7e78c2
AGING AND CALORIC RESTRICTION: A BRIEF INTRODUCTION | AMBLAGING AND CALORIC RESTRICTION: A BRIEF INTRODUCTION | AMBL
... caloric restriction may delay the development of early onset AD.. Caloric restriction has been touted as an effective, safe and ... AGING AND CALORIC RESTRICTION: A BRIEF INTRODUCTION , AMBL. Posted by Odysseus Zis , March 31, 2009 , RESOURCES, TEXTBOOK , No ... caloric restriction may represent a remarkable opportunity for preventative treatment. However, research into caloric ... Thus, caloric restriction in these paradigms does not address whether AD will still occur later in life. It is likely that the ...
https://www.bioteach.ubc.ca/aging-and-caloric-restriction-a-brief-introduction/
Effect of Caloric Restriction on Endogeous Retrovirus Expression and Lymphoma Development in Aged Rodents - American Institute...Effect of Caloric Restriction on Endogeous Retrovirus Expression and Lymphoma Development in Aged Rodents - American Institute...
Blank investigated if caloric restriction may delay the expression of a retrovirus that is associated with lymphomas, and if ... Effect of Caloric Restriction on Endogeous Retrovirus Expression and Lymphoma Development in Aged Rodents. ...
https://www.aicr.org/research/projects/effect-of-caloric-restriction-on-endogeous-retrovirus-expression-and-lymphoma-development-in-aged-rodents/
The Definitive Guide On Fasting, Autophagy, And Caloric Restriction - DPLThe Definitive Guide On Fasting, Autophagy, And Caloric Restriction - DPL
The Definitive Guide On Fasting, Autophagy, And Caloric Restriction ... The Definitive Guide On Fasting, Autophagy, And Caloric Restriction (#GotBitcoin?). Pocket-Sized Spectrometers Reveal Whats In ... The Definitive Guide On Fasting, Autophagy, And Caloric Restriction. Dr. Rhonda Patrick (FoundMyFitness) Posted FMF Clips: 14 ... Caloric Restriction Mimetics in Aging, Improved Cancer Chemotherapy, Autophagy Anti-Obesity Effect ...
https://dpl-surveillance-equipment.com/health-related/the-definitive-guide-on-fasting-autophagy-and-caloric-restriction/
Caloric restriction increases monkey lifespan, benefits healthCaloric restriction increases monkey lifespan, benefits health
... scientists have now determined that caloric restriction does help monkeys stay healthier and live longer. ... Two concurrent long-term studies came to conflicting conclusions about the health benefits of caloric restriction, but by ... caloric restriction does help monkeys stay healthier and live longer.. Caloric restriction is about eating less in general, but ... Taken in 2009, this photo shows two monkeys in a caloric restriction experiment: on the left is a 27-year-old monkey whose diet ...
https://newatlas.com/caloric-restriction-increases-monkey-lifespan/47429/
A comprehensive assessment of mitochondrial protein synthesis and cellular proliferation with age and caloric restriction. |...A comprehensive assessment of mitochondrial protein synthesis and cellular proliferation with age and caloric restriction. |...
Aging, AMP-Activated Protein Kinases, Animals, Caloric Restriction, Cell Proliferation, Deuterium Exchange Measurement, DNA, ... It is proposed that caloric restriction (CR) increases mitochondrial biogenesis. However, it is not clear why CR increases an ... A comprehensive assessment of mitochondrial protein synthesis and cellular proliferation with age and caloric restriction. ... A comprehensive assessment of mitochondrial protein synthesis and cellular proliferation with age and caloric restriction.. ...
https://health.oregonstate.edu/biblio/comprehensive-assessment-mitochondrial-protein-synthesis-and-cellular-proliferation-age-and
Caloric restriction in obese patients with mild cognitive impairment: effects on adiposity, comorbidity and cognition | NIHCaloric restriction in obese patients with mild cognitive impairment: effects on adiposity, comorbidity and cognition | NIH
Caloric restriction in obese patients with mild cognitive impairment: effects on adiposity, comorbidity and cognition. ... Caloric restriction in obese patients with mild cognitive impairment: effects on adiposity, comorbidity and cognition ... View Full Project Details for Caloric restriction in obese patients with mild cognitive impairment: effects on adiposity, ...
https://iadrp.nia.nih.gov/project/caloric-restriction-obese-patients-mild-cognitive-impairment-effects-adiposity-comorbidity
Caloric Restriction - AGE2BCaloric Restriction - AGE2B
A caloric restriction is a nutritional approach that reduces calorie consumption without causing malnutrition. This dietary ... In addition, caloric restriction has been shown to slow the aging process and extend lifespan. ... Overall, a caloric restriction is a helpful weight-loss method. However, many people may find it hard to stick to this diet. In ... A caloric restriction is a nutritional approach that reduces calorie consumption without causing malnutrition. This dietary ...
https://age2b.com/caloric-restriction/
Caloric Restriction - Bidet ConversionCaloric Restriction - Bidet Conversion
Privacy Policy , GlucoTrust , [email protected] We may earn a small commission if you click on links on our site. Thank you for your support ! Copyright tvbob.us© 2022. All Rights Reserved.. ...
https://bidetconversions.com/tag/caloric-restriction/
Caloric restriction in humans.
... Holloszy JO;FONTANA, Luigi 2007. Abstract. Studies on mice and rats have demonstrated that ... Studies on mice and rats have demonstrated that calorie restriction (CR) slows primary aging, has a protective effect against ... calorie restriction (CR) slows primary aging, has a protective effect against secondary aging, and markedly decreases the ...
https://www.iris.unisa.it/handle/11386/3871914
Caloric Restriction | Encyclopedia MDPICaloric Restriction | Encyclopedia MDPI
Luo, L.L.; Chen, X.C.; Fu, Y.C.; Xu, J.J.; Li, L.; Lin, X.H.; Xiang, Y.F.; Zhang, X.M. The effects of caloric restriction and a ... Edward J. Masoro; Overview of caloric restriction and ageing. Mechanisms of Ageing and Development 2005, 126, 913-922, 10.1016/ ... Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys. Science 2009, 325, 201-204, 10.1126/science.1173635. ... Caloric restriction (CR) is one of the primary interventions for weight loss and health maintenance. As early as the 16th ...
https://encyclopedia.pub/entry/history/show/3200
Caloric restriction reveals a lipidomic and metabolomic signature in liver of male miceCaloric restriction reveals a lipidomic and metabolomic signature in liver of male mice
... dc.contributor.author. Jové Font, ... Caloric restriction reveals a lipidomic and metabolomic signature in liver of male mice. ... but it is currently unknown whether caloric restriction (CR), an accepted life-extending intervention, affects cellular lipid ...
https://repositori.udl.cat/handle/10459.1/48741?show=full
Being cool: how body temperature influences ageing and longevity | SpringerLinkBeing cool: how body temperature influences ageing and longevity | SpringerLink
Caloric restriction and temperature. Caloric restriction, limiting calorie intake without causing malnutrition, has been shown ... Spindler SR (2010) Caloric restriction: from soup to nuts. Ageing Res Rev 9:324-353. doi:10.1016/j.arr.2009.10.003 ... Mattison JA et al (2012) Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study. Nature 489: ... Duffy PH, Feuers RJ, Leakey JA, Nakamura K, Turturro A, Hart RW (1989) Effect of chronic caloric restriction on physiological ...
https://link.springer.com/article/10.1007/s10522-015-9571-2
Hitting micros during caloric restriction. - Cronometer CommunityHitting micros during caloric restriction. - Cronometer Community
Im tired of reading studies where a diet is compared to the american standard diet and not a caloric equivalent diet. Im more ...
https://forums.cronometer.com/discussion/comment/10705/
Conscious Development: Intermittent Fasting vs. Regular Caloric RestrictionConscious Development: Intermittent Fasting vs. Regular Caloric Restriction
Regular Caloric Restriction. With regular caloric restriction I assume three meals a day and a mainly or almost exclusively ... Research indicates that caloric restrictions leads to an efficient metabolism and a slowed aging process. This can either be ... In my next article I will discuss how I go about it and combine fasting with regular caloric restriction to reap benefits of ... In my experience a shortened eating time during the day is not enough to ensure such a caloric restriction. I find myself quite ...
http://www.lauritzm.com/2017/01/intermittent-fasting-or-constant.html
Dr Sharon Mitchell | The School of Biological Sciences | The University of AberdeenDr Sharon Mitchell | The School of Biological Sciences | The University of Aberdeen
The effects of graded caloric restriction: XII. Comparison of mouse to human impact on cellular senescence in the colon. 2018 ... 2015-2020 Emem Udoh PhD "Impacts of Calorie Restriction on Behaviour and Post-restriction Hyperphagia" ... "Remodelling of three different tissues in the male C57BL/6 mouse during short-term graded caloric restriction is caused by ... The effects of graded levels of calorie restriction XVIII: tissue specific changes in cell size and number in response to ...
https://www.abdn.ac.uk/sbs/people/profiles/s.e.mitchell
Functional Medicine Testing Caloric Restriction in Type 2 DiabetesFunctional Medicine Testing Caloric Restriction in Type 2 Diabetes
Caloric Restriction in Type 2 Diabetes, Gout, Arthritis, and Heart Disease explained in this video with Functional Medicine ... Caloric Restriction in Type 2 Diabetes, Gout, Arthritis, and Heart Disease - Functional Nugget #111. by Dr. John Bartemus , Mar ...
https://www.functionalmedicinecharlotte.com/2018/03/30/caloric-restriction-in-type-2-diabetes-gout-arthritis-and-heart-disease-functional-nugget-111/
Body contouring,lipodissolve,calorie restriction,caloric restriction,body image
... calorie restriction,caloric restriction,gives beautiful body image ... Body contouring,done by lipodissolve,calorie restriction,caloric restriction,gives beautiful body image ...
https://www.aestheticandyou.com/Body_Contouring.html
Caloric restriction, hormesis and life history plasticity - ePrints - Newcastle UniversityCaloric restriction, hormesis and life history plasticity - ePrints - Newcastle University
Caloric restriction, hormesis and life history plasticity. Lookup NU author(s): Emeritus Professor Thomas Kirkwood, Dr Daryl ...
https://eprints.ncl.ac.uk/62404
Prolonged caloric restriction in obese patients with type 2 diabetes | ModifastProlonged caloric restriction in obese patients with type 2 diabetes | Modifast
Prolonged caloric restriction in obese patients with type 2 diabetes mellitus decreases myocardial triglyceride content and ... Caloric restriction reduced BMI from an average of 35.6 kg/m2 to 27.5 kg/m2 (p, 0.001). After 16 weeks, glycemic control had ... Prolonged caloric restriction in obese patients with type 2 diabetes mellitus decreases myocardial triglyceride content and ... This study shows that long-term calorie restriction in obese type 2 diabetic patients decreases BMI and significantly improves ...
https://www.modifast.ch/Prolonged-caloric-restriction-in-obese-patients-with-type-2-diabetes
Caloric Restriction and Activity to Reduce Chemoresistance in B-ALL | SurvivorNetCaloric Restriction and Activity to Reduce Chemoresistance in B-ALL | SurvivorNet
This study is being done to find out if caloric restriction achieved by a personalized nutritional menu and exercise plan ... Hypothesis: Caloric restriction with increased physical activity integrated into induction chemotherapy will decrease ... To examine efficacy of the IDEAL2 (Improving Diet and Exercise in ALL) caloric restriction and activity intervention integrated ... intervention to achieve calorie restriction through a personalized nutritional program and increased activity/exercise.. ...
https://www.survivornet.com/clinical-trials/chronic-lymphocytic-leukemia/caloric-restriction-and-activity-to-reduce-chemoresistance-in-b-all/
A systems biology analysis of the unique and overlapping transcriptional responses to caloric restriction and dietary...A systems biology analysis of the unique and overlapping transcriptional responses to caloric restriction and dietary...
A systems biology analysis of the unique and overlapping transcriptional responses to caloric restriction and dietary ... A systems biology analysis of the unique and overlapping transcriptional responses to caloric restriction and dietary ... methionine restriction in rats. Sujoy Ghosh, Desiree Wanders, Kirsten P. Stone, Nancy T. Van, Cory C. Cortez, Thomas W. Gettys ... methionine restriction in rats. , The FASEB Journal, February 2014, Wiley, DOI: 10.1096/fj.14-249458. You can read the full ...
https://www.growkudos.com/publications/10.1096%25252Ffj.14-249458/reader
Caloric restriction-mimetics for the reduction of heart failure risk in aging heart: with consideration of gender-related...Caloric restriction-mimetics for the reduction of heart failure risk in aging heart: with consideration of gender-related...
Do caloric restriction (CR)-mimetics, rich in polyphenol or polyamine, delay or reverse cardiac aging equally in both men and ... Pang, L., Jiang, X., Lian, X. et al. Caloric restriction-mimetics for the reduction of heart failure risk in aging heart: with ... Do caloric restriction (CR)-mimetics, rich in polyphenol or polyamine, delay or reverse cardiac aging equally in both men and ... Caloric restriction and its effect on blood pressure, heart rate variability and arterial stiffness and dilatation: a review of ...
https://mmrjournal.biomedcentral.com/articles/10.1186/s40779-022-00389-w
Eat to Live on Apple PodcastsEat to Live on Apple Podcasts
Is Caloric Restriction Something You Need to Worry About? Is Caloric Restriction Something You Need to Worry About? ... Calorie restriction comes up a lot when people talk about plant-based diets. A common misconception is that a plant-based diet ...
https://podcasts.apple.com/ca/podcast/eat-to-live/id1556543189
Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys. | OutcomeReference
Findings suggest the positive benefits of caloric restriction on ageing are conserved in primates. ... Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys.. 01 Apr 2014Ricki J. Colman, T. Mark Beasley ... Findings suggest the positive benefits of caloric restriction on ageing are conserved in primates. ...
https://outcomereference.com/studies/136
DNA repair - WikipediaDNA repair - Wikipedia
... an activity that is especially promoted under conditions of caloric restriction.[69] Caloric restriction has been closely ... Longevity and caloric restrictionEdit. Most life span influencing genes affect the rate of DNA damage. ... Caloric restriction reproducibly results in extended lifespan in a variety of organisms, likely via nutrient sensing pathways ... Cabelof DC, Yanamadala S, Raffoul JJ, Guo Z, Soofi A, Heydari AR (March 2003). "Caloric restriction promotes genomic stability ...
https://en.m.wikipedia.org/wiki/DNA_repair
IntakeModerate caloric restrictionCalorieLifespanDietFastingBenefits of caloric restrictionDaily caloric restrictionAbstractIncreasesLongevityPrimatesMimeticsDietary restrictionMetabolismInterventionsMitochondrialCurcuminAutophagyRatsMalnutritionCaloriesHumansDecreaseMiceAdditionallyDecreasesExtendManipulationsOxidativeMechanismResistanceChemotherapyReducesBeneficialWeight lossFindingsSearchSuggestExerciseLifeAgingTypicallyResearchProtein
Intake23
  • Individuals decreased their caloric intake by 250 to 1500 kcal/day, compared to their pre-restriction total energy intake. (contemporaryobgyn.net)
  • Calorie needs for weight loss is a daily caloric intake that falls between BMR and daily calorie requirement for maintaining current body weight. (age2b.com)
  • It is essential to not over restrict your caloric intake to prevent adverse health effects. (age2b.com)
  • You can prevent these deficits by eating whole, minimally processed foods and avoiding excessively restricting your caloric intake. (age2b.com)
  • CR applied in diverse studies ranges from 10% to up to 50% of daily caloric intake. (encyclopedia.pub)
  • Both ways should lead to a decrease in caloric intake. (lauritzm.com)
  • Therefore attention to caloric intake still has to be paid. (lauritzm.com)
  • Restriction of caloric intake increases longevity, slows the rate of functional decline, and reduces incidence of age-related disease in a variety of species. (uthscsa.edu)
  • Objectives: It is not established to what extent caloric intake must be reduced to lower oxidative stress in humans. (arizona.edu)
  • Conclusions: Oxidative stress can be rapidly reduced and sustained through a modest reduction in caloric intake suggesting potential health benefits in overweight and obese women. (arizona.edu)
  • However, the one group that was not high in body fat that underwent substantial caloric restriction, without novel training stimuli, consumed the highest protein intake out of all the groups in this review (2.5-2.6g/kg). (myflexible-fasting.com)
  • We hypothesized that curcumin intake, by decreasing adiposity, would improve cognitive function in a manner comparable to caloric restriction (CR), a weight loss regimen. (unthsc.edu)
  • So he and his lab set up tests to determine whether restricting caloric intake might confer neurological benefits. (ucihealth.org)
  • Eventually, it may be possible to show in people that reducing caloric intake, even a short-term reduction, could one day be either a recommended preventative measure or treatment, like taking an aspirin is today. (ucihealth.org)
  • In addition, normally used to (6) , while intermittent energy restriction research on fasting for other health reasons is increasing, is an eating pattern of regular daily periods of restricted such as its use as an effective and reasonably safe meth- energy intake followed by periods of unrestricted energy od to lose weight (3) . (who.int)
  • Time-restricted feeding means allowing food consumption during a much smaller period of time than people are normally used to (6), while intermittent energy restriction is an eating pattern of regular daily periods of restricted energy intake followed by periods of unrestricted energy intake (6). (who.int)
  • Data from interim years are not included with low caloric and micronutrient intake (9,17-19), but because weight-loss measurements were not part of the few studies have examined outcomes associated with core BRFSS survey instrument. (cdc.gov)
  • Reduction in caloric intake without reduction in adequate nutrition. (bvsalud.org)
  • If you have, for example, black coffee, chances are you will block further caloric intake because it only contains about 2 calories. (betterme.world)
  • However, as time went on, it became increasingly clear that the implantation of a device that uses mechanical restriction to limit caloric intake, had significant long-term drawbacks. (winthropbariatrics.com)
  • But increasing his caloric intake was going to be a challenge. (sneakz.com)
  • Until we started Sneakz and a medication that increases his appetite, his total daily caloric intake was averaging 300 to 400 calories on a good day," she says. (sneakz.com)
  • The most important contributors to the rise innoncommunicable disease are a rise in mean caloric intake and a decrease inphysical activity. (who.int)
Moderate caloric restriction3
  • To verify whether sleep quantity and quality at baseline predict the magnitude of fat loss in adults subjected to moderate caloric restriction. (nih.gov)
  • With the premise of improving obesity and its associated disorders, we investigated if fecal microbiota transplantation (FMT), heterologous and autologous, potentiates the effects of a moderate caloric restriction (CR) in high-fat diet (HFD)-induced obese mice. (nature.com)
  • The aim of this study was to determine the effect of short-term, moderate caloric restriction on markers of oxidative stress and inflammation in overweight and obese premenopausal women. (arizona.edu)
Calorie17
  • It is uncertain if an exercise program reduces the adverse effects of calorie restriction-induced weight loss in adults," wrote the Iranian authors of their review in Critical Reviews in Food Science and Nutrition . (contemporaryobgyn.net)
  • To evaluate the differences in bone mass between adults who enrolled in a calorie-restriction-alone (CR) weight loss group versus an exercise plus-calorie-restriction (CR-E) weight loss group, PubMed and Scopus libraries were searched for randomized clinical trials published up though February 2020. (contemporaryobgyn.net)
  • Further preliminary studies are required to assess bone quality in response to both calorie restriction and exercise training with reference to different time points, sex differences, hormonal and also adipokines level changes," the authors concluded. (contemporaryobgyn.net)
  • Restricting one of the twins` diet to verify whether caloric restriction mediates increases in lifespan while allowing the other to eat to satiation, and having prior knowledge that other mammals will live longer under calorie restricted diets would raise ethical alarms in the parents, the twins, and the scientific community at large. (ubc.ca)
  • A caloric restriction is a nutritional approach that reduces calorie consumption without causing malnutrition. (age2b.com)
  • Notably, some studies suggest that a mild calorie restriction during pregnancy, especially in overweight women, can be beneficial for both the mother and the child. (age2b.com)
  • Studies on mice and rats have demonstrated that calorie restriction (CR) slows primary aging, has a protective effect against secondary aging, and markedly decreases the incidence of malignancies. (unisa.it)
  • Additionally, some protocols restrict all nutrients, whereas others limit macronutrients only and supplement micronutrients in order to investigate selectively the impact of calorie reduction and prevent malnutrition making a distinction between "dietary restriction" and "energy restriction" [10]. (encyclopedia.pub)
  • The Effects of Graded Levels of Calorie Restriction: XIV. (abdn.ac.uk)
  • This study shows that long-term calorie restriction in obese type 2 diabetic patients decreases BMI and significantly improves glucose control. (modifast.ch)
  • The data also show that triglyceride storage in these patients is flexible and responsive to calorie restriction. (modifast.ch)
  • EXPERIMENTAL ARM: Standard of care nutrition education plus the updated "Improving Diet and Exercise in ALL" (IDEAL2) intervention to achieve calorie restriction through a personalized nutritional program and increased activity/exercise. (survivornet.com)
  • Calorie restriction comes up a lot when people talk about plant-based diets. (apple.com)
  • There is no substantial evidence that it increases weight loss beyond that resulting from caloric restriction, that it causes a more attractive or "normal" distribution of fat, or that it decreases the hunger and discomfort associated with calorie restricted diets. (hcgdiet.com)
  • Animal studies have repeatedly shown that calorie restriction extends the lifespan of animals, ranging from yeasts and worms to dogs, rats, and monkeys. (drjimmy.com)
  • cinnamon blood pressure sugar How To Prevent Diabetes Blood Sugar Levels high fasting blood sugar calorie restrictions Fakultas Ilmu Kesehatan. (esaunggul.ac.id)
  • This is a different approach compared to calorie restriction and for this reason many people are attracted to it. (dietarious.com)
Lifespan8
  • Since Dr. Jones` initial observation, more thorough research has revealed that dietary restriction is able to extend the lifespan of spiders fed relatively lower amounts of flies than spiders fed relatively more flies (Austad 1989). (ubc.ca)
  • In addition, caloric restriction has been shown to slow the aging process and extend lifespan. (age2b.com)
  • Caloric restriction (CR) is a traditional but scientifically verified approach to promoting health and increasing lifespan. (encyclopedia.pub)
  • Lipid composition, particularly membrane unsaturation, has been proposed as being a lifespan determinant, but it is currently unknown whether caloric restriction (CR), an accepted life-extending intervention, affects cellular lipid profiles. (udl.cat)
  • Caloric restriction (CR) delays the onset of many age-related pathophysiological changes and extends lifespan. (elsevierpure.com)
  • Cerrado Inglés Fasting, caloric restriction and foods or compounds mimicking the biological effects of caloric restriction, known as caloric restriction mimetics, have been associated with a lower risk of age-related diseases, including cardiovascular diseases, cancer and cognitive decline, and a longer lifespan. (unic.co.ao)
  • Background: Caloric restriction (CR) is considered to increase lifespan and to prevent various age-related diseases in different nonhuman organisms. (uea.ac.uk)
  • In experimental animals, caloric restriction has been shown to extend lifespan and enhance other physiological variables. (bvsalud.org)
Diet8
  • With regular caloric restriction I assume three meals a day and a mainly or almost exclusively plant-based diet. (lauritzm.com)
  • A healthful diet includes only whole foods and should make caloric restriction easier because of increased satiety. (lauritzm.com)
  • Materials/Methods: Randomized trial comparison of 25% caloric restriction (CR) or control diet in 40 overweight or obese women (body mass index 32±5.8 kg/m 2 ) observed for 28 days and followed for the next 90 days. (arizona.edu)
  • 0.001) and remained suppressed while continuing on the caloric restriction diet. (arizona.edu)
  • For instance, the authors mention that their findings might have been due to the caloric restriction involved in low-carb diets, or the overall quality of diet. (medicalnewstoday.com)
  • Therefore, a major principle of the ketogenic diet is the complete restriction of foods high in carbohydrates and their replacement with foods high in fat. (hghfor-sale.com)
  • If you have normal or low body weight and suffer from hypogonadism, a keto diet may even worsen the condition as caloric restriction has been shown to decrease the natural testosterone synthesis. (hghfor-sale.com)
  • The most well studied is a caloric restriction with a 500-750 kcal/day energy deficit diet, and 200-300 minutes of exercise per week is recommended. (medscape.com)
Fasting11
  • Today I would like to talk about the difference between caloric restriction at every meal and Intermittent Fasting. (lauritzm.com)
  • This can either be achieved by general caloric restriction or by a restricted feeding window, also called intermittent fasting. (lauritzm.com)
  • In my next article I will discuss how I go about it and combine fasting with regular caloric restriction to reap benefits of both approaches. (lauritzm.com)
  • To examine that issue, Dr Varady randomly assigned 100 obese patients to alternate-day fasting, caloric restriction, or no dietary intervention (control group) for 6 months. (medscape.com)
  • The reduction in body weight was significantly better in the fasting and restriction groups than in the control group. (medscape.com)
  • There were also significant reductions in fat mass in the fasting and restriction groups, compared with the control group. (medscape.com)
  • Fasting is an ancient form of caloric restriction. (medlineplus.gov)
  • Fasting and caloric restriction have also been shown to beneficially influence gut microbiota composition, modify host metabolism, reduce total cholesterol and triglyceride levels, lower diastolic blood pressure and elevate morning cortisol level, with beneficial modulatory effects on cardiopulmonary fitness, body fat and weight, fatigue and weakness, and general quality of life. (unic.co.ao)
  • Here, we reviewed in vitro and in vivo studies describing the effects of fasting, caloric restriction and some caloric restriction mimetics on immunosurveillance, gut microbiota, metabolism, and cancer stem cell growth, highlighting the molecular and cellular mechanisms underlying these effects. (unic.co.ao)
  • fasting includes at least two variants - time-restricted feeding and intermittent energy restriction. (who.int)
  • Eating only reduced body weight, liver fat content, fasting plasma glucose, C-peptide and glucagon, and increased OGIS, more than the same caloric restriction split into six meals,' the authors said in a statement. (canadianpharmacy-meds.com)
Benefits of caloric restriction1
  • Findings suggest the positive benefits of caloric restriction on ageing are conserved in primates. (outcomereference.com)
Daily caloric restriction2
  • This is the face of daily caloric restriction. (drjimmy.com)
  • For some, abstaining from eating or drinking a beverage with calories throughout a specified period of the day can be more of a challenge than basic daily caloric restriction (CR) using clean flexible dieting and macro counting. (tigerfitness.com)
Abstract1
  • Akbari's abstract, "Short Term Caloric Restriction Before Cardiac Arrest and Resuscitation Improves Neurological Outcome," was recognized as one of the Top 20 Posters from among the more than 350 abstracts submitted. (ucihealth.org)
Increases1
  • It is proposed that caloric restriction (CR) increases mitochondrial biogenesis. (oregonstate.edu)
Longevity7
  • The effects of dietary restriction on longevity were first described in a spider by W. Jones as early as 1884 (Jones, 1884). (ubc.ca)
  • At the time, these were interesting results, but these studies elicited a need to investigate whether longevity mediated by dietary restriction was a phenomenon shared by more advanced organisms. (ubc.ca)
  • The contributions of caloric restriction to human longevity have not been evaluated for a couple of reasons. (ubc.ca)
  • Thus, one would expect to find that these organ systems are better preserved at the same age in organisms whose longevity has been extended by caloric restriction. (ubc.ca)
  • In addition to longevity, perhaps by protection from natural aging processes, caloric restriction has also been used in animals to evaluate its effect on age-related diseases. (ubc.ca)
  • Since these early pioneering studies into temperature and longevity, more recent studies have continued to expand these ideas by using various other species as models, with further consideration of the relationship between life-extending interventions such as caloric restriction (CR) and T b . (springer.com)
  • There's a lot of research published on caloric restriction and longevity, stroke, and cancer, but not cardiac arrest. (ucihealth.org)
Primates3
  • The next step was to evaluate whether primates could experience life-preserving effects due to caloric restriction. (ubc.ca)
  • On the road to figuring out whether or not it could eventually be applied to humans, scientists began studying the effects of caloric restriction on primates. (newatlas.com)
  • Most laboratory rodent studies have initiated restriction before puberty, whereas ongoing studies in nonhuman primates utilize restriction in adulthood. (uthscsa.edu)
Mimetics3
  • Do caloric restriction (CR)-mimetics, rich in polyphenol or polyamine, delay or reverse cardiac aging equally in both men and women? (biomedcentral.com)
  • Considering the promising effects associated with caloric restriction and caloric restriction mimetics, we think that controlled-randomized large clinical trials are warranted to evaluate the inclusion of these non-pharmacological approaches in clinical practice. (unic.co.ao)
  • Oncoimmunology: A synergistic triad of chemotherapy, immune checkpoint inhibitors, and caloric restriction mimetics eradicates tumors in mice. (genosplice.com)
Dietary restriction1
  • A curated database of genes associated with dietary restriction in model organisms either from genetic manipulation experiments or gene expression profiling. (senescence.info)
Metabolism1
  • Research indicates that caloric restrictions leads to an efficient metabolism and a slowed aging process. (lauritzm.com)
Interventions2
  • Caloric restriction (CR) is one of the primary interventions for weight loss and health maintenance. (encyclopedia.pub)
  • Additionally, studies on caloric restriction interventions in cancer patients or cancer risk subjects are discussed. (unic.co.ao)
Mitochondrial1
  • A comprehensive assessment of mitochondrial protein synthesis and cellular proliferation with age and caloric restriction. (oregonstate.edu)
Curcumin1
  • dietary curcumin and caloric restriction have positive effects on frontal cortical functions that could be linked to anti-inflammatory or antioxidant actions. (unthsc.edu)
Autophagy1
  • Autophagy stimulation via reduction of lysine acetylation, increased sensitivity to chemo- and immunotherapy, along with a reduction of insulin-like growth factor 1 and reactive oxygen species have been described as some of the major effects triggered by caloric restriction. (unic.co.ao)
Rats1
  • The age-related paraoxonase 1 response is altered by long-term caloric restriction in male and female rats. (bvsalud.org)
Malnutrition2
  • Caloric restriction is about eating less in general, but it requires the right balance because going too far in the other direction can lead to malnutrition and a potential loss of muscle mass and bone density. (newatlas.com)
  • A second emphasis of our research focuses on the effects of caloric restriction (CR) without malnutrition on the NK cell response to influenza infection. (msu.edu)
Calories1
  • The caloric restriction approach involves reducing the number of calories consumed while maintaining adequate nutrition. (age2b.com)
Humans2
Decrease2
  • Many life-extending manipulations in rodents, such as caloric restriction, also decrease core body temperature. (springer.com)
  • Hypothesis: Caloric restriction with increased physical activity integrated into induction chemotherapy will decrease chemoresistance and reduce minimal residual disease (MRD). (survivornet.com)
Mice3
  • Dr. Blank investigated if caloric restriction may delay the expression of a retrovirus that is associated with lymphomas, and if the delay in viral expression also delays the development of lymphoma in mice. (aicr.org)
  • 2011-2013 MRes Nicole Culbert , "Does Hunger Neuropeptide and Energy Balance Manipulation Affect Metabolic Rate and Antioxidant Activity in C57BL/6 Mice under Caloric Restriction? (abdn.ac.uk)
  • Natural killer cell maturation and function in C57Bl/6 mice is altered by caloric restriction. (msu.edu)
Additionally1
  • Additionally, chronic caloric restriction is heavily studied while the potential benefits of very short-term caloric restriction are not. (ucihealth.org)
Decreases1
  • It is worth mentioning that caloric restriction decreases testosterone levels to some extent. (age2b.com)
Extend1
  • Severe caloric restriction-like not eating every other day-has been found to extend the lives, and improve cognition, of animals in laboratories. (nutritionfacts.org)
Manipulations1
  • Projects focused on gene expression profiling of ageing and of dietary manipulations of ageing, such as caloric restriction. (senescence.info)
Oxidative1
  • Caloric restriction (CR) has been shown to attenuate age-related oxidative damage and to improve major atherosclerotic risk factors . (bvsalud.org)
Mechanism2
  • By understanding the mechanism of how caloric restriction provides neuroprotection from cardiac arrest, we can attempt to define those pathways and investigate their role and applicability in people. (ucihealth.org)
  • However, if a new mechanism for restriction is not used, patients tend to regain their weight. (winthropbariatrics.com)
Resistance3
  • Five out of these six groups were among the highest in body fat, lowest in caloric restriction, or underwent novel resistance training stimuli. (myflexible-fasting.com)
  • Conclusions: Protein needs for energy-restricted resistance-trained athletes are likely 2.3-3.1g/kg of FFM scaled upwards with severity of caloric restriction and leanness. (myflexible-fasting.com)
  • Together, the data suggest that caloric restriction enhances resistance to gram-positive bacteria, while lowering the production of proinflammatory mediators elicited by endotoxin, a component of gram-negative bacteria. (cdc.gov)
Chemotherapy1
  • This study is being done to find out if caloric restriction achieved by a personalized nutritional menu and exercise plan during routine chemotherapy can make the patient's ALL more sensitive to chemotherapy and also reduce the amount of body fat gained during treatment. (survivornet.com)
Reduces2
Beneficial2
  • Animal studies suggest caloric restriction is beneficial, but what does some of the first human data show? (nutritionfacts.org)
  • The next step, he says, is to test in rodent models whether caloric restriction after, rather than before, cardiac arrest might be beneficial. (ucihealth.org)
Weight loss2
  • Caloric restriction is one of several restrictive approaches leading to weight loss accompanied by increased health span and life span. (encyclopedia.pub)
  • Typically, patients opt for a gastric sleeve, which provides restriction and excellent long-term weight loss and disease resolution results. (winthropbariatrics.com)
Findings1
  • These findings are promising, and suggest that caloric restriction may promote attenuation of aging-related processes, such as sarcopenia. (ubc.ca)
Search1
  • We did not apply language restrictions, and for search engines that allowed it, we included only articles about studies with human subjects. (cdc.gov)
Suggest1
  • Though the mechanisms underlying sarcopenia have not been defined, studies suggest that sarcopenia may be attenuated by caloric restriction. (ubc.ca)
Exercise1
Life3
  • And finally it should be made clear that this article is evaluating the pros and cons of these approaches in the light of life-long caloric restriction. (lauritzm.com)
  • McCarter, RJM 1995, ' Role of caloric restriction in the prolongation of life ', Clinics in Geriatric Medicine , vol. 11, no. 4, pp. 553-565. (uthscsa.edu)
  • The life extension can be dramatic, up to 80% in some cases and the restriction does not have to be lifelong. (drjimmy.com)
Aging1
  • These conflicting outcomes had cast a shadow of doubt on the translatability of the caloric-restriction paradigm as a means to understand aging and what creates age-related disease vulnerability," says Rozalyn Anderson, a corresponding author on the study. (newatlas.com)
Typically1
Research1
  • Physical training can preserve and even significantly bolster bone mass in the hip and femoral neck of individuals under caloric restriction, according to new research. (contemporaryobgyn.net)
Protein1
  • Duncan, born prematurely and with a long list of dietary restrictions including gluten, soy, many fruits and excessive protein, is what his mom Ashley calls a "food avoider. (sneakz.com)
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Eat to Live on Apple Podcasts
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Effect of Caloric Restriction on Endogeous Retrovirus Expression and Lymphoma Development in Aged Rodents - American Institute...
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Exercise, bone mass and caloric restriction
Exercise, bone mass and caloric restriction (contemporaryobgyn.net)
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New Mineral Absorption Enhancers Found | NutritionFacts.org (nutritionfacts.org)
Elizabeth M. Gardner
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Low-Fat Diets Not More Effective Than Other Diets
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Low-Carb Diet Improves In Vitro Fertilization
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Learning with McCell - part 8: Peroxide number | Mibelle Biochemistry (mibellebiochemistry.com)
Obesity Medication: Gastrointestinal Agents, Other, CNS Stimulants, Anorexiants, Glucagonlike Peptide-1 Agonists,...
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Age-dependent increase of oxidative stress regulates microRNA-29 family preserving cardiac health | Scientific Reports
Age-dependent increase of oxidative stress regulates microRNA-29 family preserving cardiac health | Scientific Reports (nature.com)
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