Phenolic metacyclophanes derived from condensation of PHENOLS and ALDEHYDES. The name derives from the vase-like molecular structures. A bracketed [n] indicates the number of aromatic rings.

Sulphonic acid derivatives as probes of pore properties of volume-regulated anion channels in endothelial cells. (1/86)

1. We have used the whole-cell patch-clamp technique to study the effects of 4-sulphonic-calixarenes and some other poly-sulphonic acid agents, such as suramin and basilen blue, on volume-regulated anion channel (VRAC) currents in cultured endothelial cells (CPAE cells). 2. The 4-sulphonic-calixarenes induced a fast inhibition at positive potentials but were ineffective at negative potentials. At small positive potentials, 4-sulphonic-calix[4]arene was a more effective inhibitor than 4-sulphonic-calix[6]arene and -calix[8]arene, which became more effective at more positive potentials. 3. Also suramin and basilen blue induced a voltage dependent current inhibition, reaching a maximum around +40 mV and declining at more positive potentials. 4. The voltage dependence of inhibition was modelled by assuming that these negatively charged molecules bind to a site inside VRAC that senses a fraction delta of the applied electrical field, ranging beween 0.16 to 0.32. 4-Sulphonic-calix[4]arene, suramin and basilen blue bind and occlude VRAC at moderate potentials, but permeate the channel at more positive potentials. 4-Sulphonic-calix[6]arene and -calix[8]arene however do not permeate the channel. From the structural information of the calixarenes, we estimate a lower and upper limit of 11*12 and 17*12 A2 respectively for the cross-sectional area of the pore.  (+info)

Anatomy, physiology, and synaptic responses of rat layer V auditory cortical cells and effects of intracellular GABA(A) blockade. (2/86)

The varied extracortical targets of layer V make it an important site for cortical processing and output, which may be regulated by differences in the pyramidal neurons found there. Two populations of projection neurons, regular spiking (RS) and intrinsic bursting (IB), have been identified in layer V of some sensory cortices, and differences in their inhibitory inputs have been indirectly demonstrated. In this report, IB and RS cells were identified in rat auditory cortical slices, and differences in thalamocortical inhibition reaching RS and IB cells were demonstrated directly using intracellular GABA(A) blockers. Thalamocortical synaptic input to RS cells was always a combination of excitation and both GABA(A) and GABA(B) inhibition. Stimulation seldom triggered a suprathreshold response. IB cell synaptic responses were mostly excitatory, and stimulation usually triggered action potentials. This apparent difference was confirmed directly using intracellular chloride channel blockers. Before intracellular diffusion, synaptic responses were stable and similar to control conditions. Subsequently, GABA(A) was blocked, revealing a cell's total excitatory input. On GABA(A) blockade, RS cells responded to synaptic stimulation with large, suprathreshold excitatory events, indicating that excitation, while always present in these cells, is masked by GABA(A). In IB cells that had visible GABA(A) input, it often masked an excitatory postsynaptic potential (EPSP) that could lead to additional suprathreshold events. These findings indicate that IB cells receive less GABA(A)-mediated inhibitory input and are able to spike or burst in response to thalamocortical synaptic stimulation far more readily than RS cells. Such differences may have implications for the influence each cell type exerts on its postsynaptic targets.  (+info)

Permeabilization via the P2X7 purinoreceptor reveals the presence of a Ca2+-activated Cl- conductance in the apical membrane of murine tracheal epithelial cells. (3/86)

Calcium-activated Cl(-) secretion is an important modulator of regulated ion transport in murine airway epithelium and is mediated by an unidentified Ca(2+)-stimulated Cl(-) channel. We have transfected immortalized murine tracheal epithelial cells with the cDNA encoding the permeabilizing P2X(7) purinoreceptor (P2X(7)-R) to selectively permeabilize the basolateral membrane and thereby isolate the apical membrane Ca(2+)-activated Cl(-) current. In P2X(7)-R-permeabilized cells, we have demonstrated that UTP stimulates a Cl(-) current across the apical membrane of CF and normal murine tracheal epithelial cells. The magnitude of the UTP-stimulated current was significantly greater in CF than in normal cells. Ion substitution studies demonstrated that the current exhibited a permselectivity sequence of Cl(-) > I(-) > Br(-) > gluconate(-). We have also determined a rank order of potency for putative Cl(-) channel blockers: niflumic acid > or = 5-nitro-2-(3-phenylpropylamino)benzoic acid > 4, 4'-diisothiocyanostilbene-2,2'-disulfonate > glybenclamide >> diphenlyamine-2-carboxylate, tamoxifen, and p-tetra-sulfonato-tetra-methoxy-calix[4]arene. Complete characterization of this current and the corresponding single channel properties could lead to the development of a new therapy to correct the defective airway surface liquid in cystic fibrosis patients.  (+info)

Emergent mechanical properties of self-assembled polymeric capsules. (4/86)

Synthetic self-assembled systems combine responsiveness and reversibility with the ability to perform chemical tasks such as molecular recognition and catalysis. An unmet challenge is the construction of polymeric materials that, like nature's tubulin, are simultaneously reversible and capable of useful physical tasks. We report here a class of reversibly formed polymers that show covalent-polymer mechanical integrity in solution and in the solid state. Non-Newtonian, polymeric behavior is observed despite the low molecular weight of the individual subunits and the seemingly weak forces holding the assemblies together. These polymers assemble through self-complementary hydrogen bonding and by physical encapsulation of small molecules; accordingly, the emergent macroscopic structure and function can be controlled by appropriate chemical signals.  (+info)

An improved Na+-selective microelectrode for intracellular measurements in plant cells. (5/86)

The high background K+ concentration in plant cells is a problem for intracellular measurements of Na+ using ion-selective microelectrodes. The discrimination between Na+ and K+ of the microelectrode ionophore molecule limits the usefulness of this technique. A new Na+-selective microelectrode with an ionophore incorporating a tetramethoxyethyl ester derivative of p-t-butyl calix[4]arene has been developed. Microelectrodes made with this new sensor have superior selectivity for Na+ over K+ resulting in a lower limit of detection when compared with microelectrodes made using a commercially available ionophore (ETH227). Both types of microelectrodes were insensitive to changes in ionic strength and physiological ranges of pH, but only the calixarene-based electrodes showed no protein interference. To test the suitability of the calixarene-based microelectrodes for measurements in plants, they were used to measure Na+ in epidermal cells in the zone 10-20 mm from the root apex of barley (Hordeum vulgare L.). Seedlings were grown in a nutrient solution containing 200 mM NaCl for 1-6 d. The range of intracellular Na+ activity (a(Na)) measured varied from < or =0.1 mM (limit of detection) to over 100 mM, and these values increased significantly with time. The membrane potential (E(m)) of these cells was variable, but the values became significantly more negative with time, although there was no significant correlation between E(m) and a(Na). These intracellular measurements could not be separated into distinct populations that might be representative of subcellular compartments.  (+info)

Interchain hydrogen-bonding interactions may facilitate translocation of K+ ions across the potassium channel selectivity filter, as suggested by synthetic modeling chemistry. (6/86)

A 4-fold symmetric arrangement of TVGYG polypeptides forms the selectivity filter of the K+ channel from Streptomyces lividans (KcsA). We report the synthesis and properties of synthetic models for the filter, p-tert-butyl-calix[4]arene-(OCH(2)CO-XOBz)(4) (X = V, VG, VGY), 1-3. The first cation (Na+, K+) binds to the four -[OCH(2)CO]- units, a region devised to mimic the metal-binding site formed by the four T residues in KcsA. NMR studies reveal that cations and valine amide protons compete for the carbonyl oxygen atoms, converting NH(Val)...O=C hydrogen bonds to M+ ...O=C bonds (M+ = Na+ or K+). The strength of these interchain NH(Val)...O=C hydrogen bonds varies in the order 3 > 2 > 1. We propose that such interchain H-bonding may destabilize metal binding in the selectivity filter and thus help create the low energy barrier needed for rapid cation translocation.  (+info)

Facile formation of chiral calixarene analogs incorporating cystine peptide into the macrocyclic ring. (7/86)

Chiral calixarene analogs incorporating cystine peptide into their macrocyclic ring were easily prepared by the cyclization reactions of bis(chloromethyl)phenol-formaldehyde oligomers with cystine peptides in moderate yields. Circular dichroism (CD) spectra indicated the existence of the transmission of the chirality from peptide unit to phenol-formaldehyde oligomer moiety.  (+info)

Cytosine substituted calix[4]pyrroles: neutral receptors for 5'-guanosine monophosphate. (8/86)

The synthesis and characterization of two cytosine-substituted calix[4]pyrrole conjugates, bearing the appended cytosine attached at either a beta- or meso-pyrrolic position, is described. These systems were tested as nucleotide-selective carriers and as active components of nucleotide-sensing ion-selective electrodes at pH 6.6. Studies of carrier selectivity were made using a Pressman-type model membrane system consisting of an initial pH 6.0 aqueous phase, an intervening dichloromethane barrier containing the calix[4]pyrrole conjugate, and a receiving basic aqueous phase. Good selectivity for the Watson-Crick complementary nucleotide, 5'-guanosine monophosphate (5'-GMP), was seen in the case of the meso-linked conjugate with the relative rates of through-membrane transport being 7.7:4.1:1 for 5'-GMP, 5'-AMP, and 5'-CMP, respectively. By contrast, the beta-substituted conjugate, while showing a selectivity for 5'-GMP that was enhanced relative to unsubstituted calix[4]pyrrole, was found to transport 5'-CMP roughly 4.5 times more quickly than 5'-GMP. Higher selectivities were also found for 5'-CMP when both the beta- and meso-substituted conjugates were incorporated into polyvinyl chloride membranes and tested as ion selective electrodes at pH 6.6, whereas near-equal selectivities were observed for 5'-CMP and 5'-GMP in the case of unsubstituted calix[4]pyrroles. These seemingly disparate results are consistent with a picture wherein the meso-substituted cytosine calix[4]pyrrole conjugate, but not its beta-linked congener, is capable of acting as a ditopic receptor, binding concurrently both the phosphate anion and nucleobase portions of 5'-GMP to the calixpyrrole core and cytosine "tails" of the molecule, respectively, with the effect of this binding being most apparent under the conditions of the transport experiments.  (+info)

Our Viewpoints focus the spotlight on significant impacts and breakthroughs resulting from ChemComm articles in the last century, and can serve as catalysts for active discussion and inspiration within the community.. Earlier this year, Jack Harrowfields Viewpoint focussing on the 1985 contribution of Tony McKerveys group to the field of calixarenes and cations generated an enthusiastic response, including suggestions on other articles that were also felt to have played a seminal role in calixarene chemistry. As a result, we have recently published an alternative Viewpoint by Alessandro Casnati on the impact of Communications published (in 1983 and 1984) by the group of Rocco Ungaro and Andrea Pochini.. Read both Viewpoints now and see the impact these groundbreaking Comms created:. ...
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Calixarenes bear a fascinating class of macrocycles that have served broadly in molecular recognition and supramolecular chemistry. These, supramolecular structures have been utilized in several different directions ranging from catalysis to therapy.
Calix[4]tetra-diazonium cations generated in situ from the corresponding tetra-anilines were electrografted on gold and carbon substrates. The well-preorganized macrocyclic structure of the calix[4]arene molecules allows the formation of densely packed monolayers. Through adequate decoration of the small rim of the calixarenes, functional molecules can then be introduced on the immobilized calixarene subunits, paving the way for an accurate spatial control of the chemical composition of a surface at molecular level. One cool experiment is determination of surface coverage by functionalizing the electrode with COOH terminated calixarenes and then coupling on Fc moieties and doing CV ...
We investigated the influence of calixarene C-90 and IPT-35 on plasma membrane Ca2+- pumping АТРase (PMCA), intracellular calcium homeostasis and myometrium smooth muscle strain contractions. It has been shown that both effectors (100 μM) affect PMCA enzymatic activity: calixarene C-90 inhibits it b …
TY - CONF. T1 - Development of a time-resolved immunoassay delay system based on lanthanide ions complexed by calixarene derivatives. AU - Steemers, F.J.. AU - Rudkevich, D.M.. AU - van der Tol, E.B.. AU - Verboom, Willem. AU - Verhoeven, J.W.. AU - Reinhoudt, David. PY - 1994/10/10. Y1 - 1994/10/10. M3 - Poster. T2 - Bijeenkomst SON-werkgemeenschap Organische Synthese 1994. Y2 - 10 October 1994 through 11 October 1994. ER - ...
Synthetic and structural studies of europium complexes of calix[8]arene, p-t-Bu-calix[7]arene and p-t-Bu-calix-[9]arene are reported. The complex [Eu2(calix[8]arene-6H)(dmso)5] was found to have a similar structure topreviously reported p-t-Bu- and p-nitro-calix[8]arene complexes of the lanthanides. Despite being prepared undersimilar conditions, the complex of p-t-Bu-calix[7]arene was found to be a tetranuclear assembly, formulated as[(HO)2(OCO2)Eu4(p-t-Bu-calix[7]arene-4H)2(dmso)6]. Expanding the ligand to p-t-Bu-calix[9]arene resulted in theisolation of a larger oligonuclear assembly, [(HO)9(H2O)2Eu7(p-t-Bu-calix[9]arene-6H)2(dmso)6]. In contrast to theconsistent structural type found with the calix[8]arene system, however, use of a different solvent (acetone) gave riseto a much simpler species, [Eu2(p-t-Bu-calix[9]arene-3H)2(dmso)4].. ...
Authors: MUSTAFA YILMAZ, SERKAN ERDEMİR Abstract: Calixarene-based molecular receptors have been a widely developing area in material science and technology for the last few decades. Due to their bowl-shaped geometry, calixarene macrocycles are used as hosts allowing organic and inorganic guests to coordinate/sorb onto their cavity. This work briefly reviews the recent development of calixarenes. Keywords: Calixarene, receptor, host-guest, drugs, chiral, lipase Full Text: PDF ...
Due to their recognition properties and efficiency for the detection of toxic metals, calixarenes have already found applications in the design of chemical sensors based on using an electrochemical transduction. In this study, a new chromogenic azo-calix[4]arene derivative was deposited on gold electrode by spin coating to develop a new electrochemical sensor. Adhesion and morphological properties of the membrane have been firstly developed using contact angle measurements and scanning electronic microscopy (SEM) respectively. Electrochemical impedance spectroscopy (EIS) is used to study the response of the calixarenes membrane in contact with aqueous solutions of various metallic cations. The impedance behavior of the structures has been modeled by an equivalent circuit using the Z-View software. This technique has shown a selective response of this membrane towards Hg(2+), Ni(2+) and Eu(3+). The differences in selectivity are found to be represented by variations in the resistance of the membrane (R(m
ENGLISH ABSTRACT: Resorcinarenes are macrocyclic products formed from the condensation of aldehydes (aliphatic or aromatic) and resorcinol and have been used in a wide range of applications since their first synthesis. Applications include: HPLC stationary phases for the separation of pyrimidine bases, racemic drugs and isomers, the selective extractions of lanthanides and actinides, as molecular receptors, catalysis, NMR chiral shift agents, GC separations and as starting materials for the synthesis of macrocyclic compounds (e.g. cavitands and carcerands) to name but a few. The use of resorcinarenes in catalysis is still quite new and unexplored, while catalysis using calix[4]arenes, a related macrocycle, has been widely studied. In this thesis it was attempted to synthesise a C2v symmetric resorcinarene precursor that could be further functionalised to form distal bidentate ligands for coordination to transition metals. These compounds would then ultimately be used in catalytic testing, ...
Reading ModeOn 8th August this year, I posted on a fascinating article that had just appeared in Science in which the crystal structure was reported of two small molecules, 1,3-dimethyl cyclobutadiene and carbon dioxide, entrapped together inside a calixarene cavity. Other journals (e.g. Nature Chemistry ran the article as a research highlight (where the purpose is not a critical […]
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Following an introduction on calixarene chemistry and their metal-ion complexes including some of their applications, the aim of the work are described. Thus this thesis concentrates on the synthesis and characterisation of two new lower rim calix(4)arene derivatives containing mixed pendent arms as well as an investigation on the solution properties of their metal-ion complexes. Macrocycles namely, 5, 11, 17, 23 tetrakis (1, 1 dimethylethyl) 25, 27- bis [(2-methylthio) ethoxy] 26, 28-bis [2- pyridyl methyloxy] calix(4)arene, L1 and 5, 11, 17, 23 tetrakis (1, 1 dimethylethyl) 25, 27- bis [(2- methylthio) ethoxy] 26, 28-bis [3-pyridyl methyloxy] calix(4)arene, L2, are structurally (1H NMR and X-ray crystallography) and thermodynamically (solubility, Gibbs energy, enthalpy and entropy) characterised. The complexing ability of these ligands for metal cations is investigated using a variety of techniques. Solubility measurements and derived standard transfer Gibbs energies of these isomers indicate ...
TY - JOUR. T1 - ANION RECEPTOR MOLECULES - SYNTHESIS AND ANION-BINDING PROPERTIES OF POLYAMMONIUM MACROCYCLES. AU - DIETRICH, B AU - HOSSEINI, M W AU - LEHN, J M AU - SESSIONS, R B PY - 1981. Y1 - 1981. M3 - Comment/debate (Academic Journal). VL - 103. SP - 1282. EP - 1283. JO - Journal of the American Chemical Society. JF - Journal of the American Chemical Society. SN - 0002-7863. IS - 5. ER - ...
Fingerprint Dive into the research topics of Phenylene-bridged core-modified planar aromatic octaphyrin: Aromaticity, photophysical and anion receptor properties. Together they form a unique fingerprint. ...
Demonstrated herein is a single rapid approach employed for synthesis of Ag-graphene nanocomposites, with excellent antibacterial properties and low cytotoxicity, by utilizing a continuous hydrothermal flow synthesis (CHFS) process in combination with p-hexasulfonic acid calix[6]arene (SCX6) as an effective particle stabilizer. The nanocomposites showed high activity against E. coli (Gram-negative) and S. aureus (Gram-positive) bacteria. The materials were characterized using a range of techniques including transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), Raman spectroscopy, UV-vis spectrophotometry, FT-IR, and X-ray powder diffraction (XRD). This rapid, single step synthetic approach not only provides a facile means of enabling and controlling graphene reduction (under alkaline conditions) but also offers an optimal route for homogeneously producing and depositing highly crystalline Ag nanostructures into reduced graphene oxide substrate.. ...
In this work the applicability of calix[6]arene columns for actinides analysis in urine samples and drinking water was investigated. A radiochemical procedure has been developed for U, Pu, Am analysis in urine. A simple and effective method has also been proposed on a specific column named AQUALIX, for the separation and preconcentration of U from drinking water. These procedures are suitable for routine analysis and require a considerably reduced number of steps of sample treatment as compared to current procedures ...
In supramolecular chemistry, host-guest chemistry describes complexes that are composed of two or more molecules or ions that are held together in unique structural relationships by forces other than those of full covalent bonds. Host-guest chemistry encompasses the idea of molecular recognition and interactions through noncovalent bonding. Noncovalent bonding is critical in maintaining the 3D structure of large molecules, such as proteins and is involved in many biological processes in which large molecules bind specifically but transiently to one another. There are four commonly mentioned types of non-covalent interactions: hydrogen bonds, ionic bonds, van der Waals forces, and hydrophobic interactions. Common host molecules are cyclodextrins, calixarenes, pillararenes, cucurbiturils, porphyrins, metallacrowns, crown ethers, zeolites, cyclotriveratrylenes, cryptophanes, carcerands, and foldamers. Host-guest chemistry is observed in inclusion compounds, Intercalation compounds, clathrates, and ...
Functionalizing the upper rim of resorcinarene-based cavitands allows a variety of compounds to be synthesized from a single scaffold. Using the upper-rim moieties as ligands for a variety of transition metal ions further increases the versatility of this class of host compounds. A new resorcinarene-based molecule functionalized with four pyridine and acetic acid ligands has been successfully prepared to explore the properties of metal-assembled complexes. To synthesize this compound, tetra(bromomethyl)cavitand was reacted with N-(2-pyridylmethyl)-N-ethylacetate amine to give ethyl acetate pyridine resorcinarene. Hydrolysis of the ester gave acetic acid pyridine resorcinarene (APRes) in good yield. Complexes with Cu2+, Co2+, and Zn2+ are currently being investigated and characterized by MS and 1H and 13C NMR.
We are interested in all aspects of coordination, organometallic and metallo-supramolecular chemistry with a particular emphasis upon the synthesis of cavity-shaped ligands and their use in organometallic catalysis and green chemistry. Much of our work relies on macrocyclic molecules, such as calixarenes, resorcinarenes, and cyclodextrins. The latter may be used as receptors or serve as platforms for the construction of multifunctional podands.. ...
This invention describes a new concept of flexible template-directed microporous partially pyrolyzed polymeric membranes which have greatly improved performance in separation of gas pairs compared to their precursor polymeric membranes. Organic hosts, such as crown ethers, cyclodextrins (CDs), calixarenes (CXs), and spherands, or polymeric additives, such as poly(ethylene glycol) (PEG) and polyvinylpyrrolidone (PVP) were used as the micropore-forming templates. Micropore-forming template/polymer blend membranes comprising organic micropore-forming templates embedded in a polymer matrix were prepared by dissolving the organic micropore-forming templates in the polymer solution followed by solution-casting and solvent evaporation or solvent exchange. Low-temperature selectively pyrolyzing micropore-forming templates in the micropore-forming template/polymer blend membranes at a nitrogen flow resulted in the formation of flexible microporous partially pyrolyzed polymeric membranes.
Importantly, many of the techniques we use to characterize these materials are frequently used throughout organic chemistry and include NMR, UV-Vis spectroscopy, cyclic voltammetry, and IR spectroscopy. These are all excellent techniques students may add to their organic chemistry resume, which will help prepare them for a multitude of potential career paths Advanced Time-Correlated Single Photon Counting Techniques (Springer Series in Chemical Physics) http://detroitpaintandglass.com/?lib/advanced-time-correlated-single-photon-counting-techniques-springer-series-in-chemical-physics. Martin na Muri (Croatia) during September 3-7, 2016 ref.: Calixarenes 2001 read pdf eatdrinkitaly.org. More information on these and other projects can be found on Prof. A complete publication list is available from Professor Herberts research web page. Some representative publications from the last few years are listed here. Low-scaling quantum chemistry approach to excited-state properties via an ab initio ...
This story starts with a calixarene, a molecule (suitably adorned with substituents) frequently used as a host to entrap a guest and perchance make the guest do something interesting. Such a calixarene was at the heart of a recent story where an attempt was made to induce it to capture cyclobutadiene in its cavity.. (more…). ...
GFB-204 is a calixarene derivative that is a potent and selective inhibitor of VEGFR and PDGFR tyrosine phosphorylation. G FB-204 had been shown through several in-vivo and in-vitro studies to bind to VEGF and PDGF, block binding of VEGF and PDGF to their receptors and subsequently inhibit Flk-1 and PDGFR tyrosine phosphorylation and stimulation of the protein kinases Erk1, Erk2, and AKT and the signal transducer and activator of transcription STAT3. Since tumor angiogenesis depends on VEGF for initiation and PDGF for maintenance of blood vessels, an agent which suppresses the functions of both VEGF and PDGF would potentially be more effective in tumor control that an agent which targets only one of these two growth factors. Preclinical studies have also shown that GFB-204 inhibits capillary network formation in a dose-response manner and inhibits VEGF-dependent human brain endothelial cell migration. A lung xenograft study in mice has shown that GFB-204 is active in a dose dependent manner.
Calixarene-Based Molecules for Cation Recognition. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
Anion complexation studies on a series of platinum( II) tetrakis( pyrrolylpyridine) salts demonstrate the importance of CH-anion hydrogen bonds in coordinating anionic guests in solution and the solid-state.. Full text not available from this repository.. ...
The thesis deals with an investigation on calix[4] based receptors, namely calix[4]pyrrole and calix[4]arene derivatives and their use in different environmental and medical applications. The work conducted throughout this study addresses three main topics. i) The first topic discusses the ability of meso-octamethylcalix[4]pyrrole, CP to remove arsenite and arsenate anions from natural waters. Sites and nature of interaction of the receptor with the investigated anions using 1H NMR and molecular simulation studies are identified. Optimal environmental conditions led to maximal uptake of the investigated anions by CP, uptake capacity of the receptor and the kinetics of the process for the investigated anions are determined. CP was used to remove arsenic species from real water samples and its efficiency is demonstrated. ii) The second topic is related to the synthesis and structural characterisation of two thioacetamide calix[4]pyrrole derivatives namely, ...
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This doctoral thesis deals with the synthesis and binding studies of novel receptors based on aryl-extended calix[4]pyrrole scaffolds. Specifically, we describe a new synthetic methodology for the synthesis of water-soluble aryl-extended calix[4]pyrrole functionalized with water solubilizing groups distal to the binding site. This strategy avoids possible perturbation during the complex formation and permits the future construction of more elaborated receptors. We report the binding studies of these new water-soluble receptors with a series of pyridine N-oxides derivatives in water. The results obtained highlighted the ability of the aromatic cavity to protect and ensure the formation of hydrogen-bonding interactions in water. We also describe the synthesis of a new monophosphonate receptor for the selective recognition of neutral creatinine and creatininium cation in organic solution. Our studies demonstrate that the new monophosphonate receptor is able to form complexes with creatinine and ...
Two new types of methylcalix[4]resorcinarene-bonded stationary phases, (3-(C-methylcalix[4]resorcinarene)-2-hydroxypropoxy)-propylsilyl-appended silica particles (MCR-HPS) and bromoacetate-substituted MCR-HPS particles (BAMCR-HPS), have been synthesized and used as chiral stationary phases for high-performance liquid chromatography (HPLC) for the first time. The synthetic stationary phases are characterized by means of elemental analysis and Fourier-transform infrared spectroscopy. The chromatographic behavior of MCR-HPS and BAMCR-HPS was studied with several disubstituted benzenes and some chiral drug compounds under both normal phase and reversed-phase conditions. The results show that MCR-HPS has excellent selectivity for the separation of aromatic positional isomers and BAMCR-HPS exhibits excellent performance for separation of enantiomers of chiral compounds. © 2011 Wiley Periodicals, Inc ...
TY - JOUR. T1 - Supramolecular solids as a medium for single-crystal-to-single-crystal E/Z photoisomerization. T2 - Kinetic study of the photoreactions of two Zn-coordinated tiglic acid molecules. AU - Zheng, Shao Liang. AU - Velde, Christophe M.L.Vande. AU - Messerschmidt, Marc. AU - Volkov, Anatoliy. AU - Gembicky, Milan. AU - Coppens, Philip. PY - 2008. Y1 - 2008. N2 - [Zn(TA)2(H2O)2] (H-TA = tiglic acid) has been embedded in a framework composed of CECR (CECR = C-ethylcalix[4] resorcinarene) molecules to examine its E→Z photoisomerization in a periodic framework. The photoisomerization of tiglic acid in CECR-[Zn(TA) 2(H2O)2]·4H2O proceeds without the [2 + 2]-dimerization reaction that often occurs in crystals of uncomplexed analogues, and without breakdown of the crystal lattice thatfrequently occurs in neat crystals. The two Zn-coordinated TA molecules are located in different size cavities. The rate constants of the isomerization reaction are strongly affected by the size of the ...
We introduce bis-aryl croconamides as a new member in the family of dual hydrogen bonding anion receptors. In this study a series of croconamides are synthesised, and the selectivity for anion binding is investigated (Cl− | Br− | I− in CH2Cl2). The croconamides exhibit different structures in the crystal pha
Bismuth(III) was quantitatively extracted from 0.1 M HCl with 1×10-4M of hexaacetato calix(6)arene in toluene. It was stripped with 2 M nitric acid and determined from the aqueous phase spectrophotometrically at 470 nm as its complex with thiourea. The various parameters such as pH, reagent concentration, kind of diluents, stripping agents, effect of diverse ions were studied to ascertain optimum conditions for the quantitative extraction of bismuth . Bismuth was separated from thorium(IV), iron(III), manganese(II), chromium(III). lead(II), palladium(II) and thallium(III) in multicomponent mixtures. The method was extended for the analysis of bismuth in real samples ...
B. Korchowiec, A. B. Salem, Y. Corvis, J. B. Reguouf de Vains, J. Korchowiec, E. Rogalska, Calixarenes in a membrane environment: A monolayer study on the miscibility of three p-tert-butylcalix[4]arene β-lactam derivatives with 1,2-dimyristoyl-sn-glycero-3-phosphoethanolamine, J. Phys. Chem. B, 111 (2007) 13231-13242 ...
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Formation of Amines (RNH2) and the Cyanide Anion (CN-) in Electron-Irradiated Ammonia-Hydrocarbon Interstellar Model Ices. The present laboratory study simulated cosmic-ray-induced grain chemistry of nitrogen-bearing organic molecules in interstellar and cometary ices. Model ices of ammonia (NH3)-methane (CH4) were prepared and irradiated at 10 K under contamination-free, ultrahigh vacuum conditions with energetic electrons generated in the track of galactic cosmic-ray particles. The radiolysis-induced processing of nitrogen-bearing molecules was then monitored on line and in situ by a Fourier transform infrared spectrometer and a quadrupole mass spectrometer during the irradiation phase and subsequent warm-up phases. The analogous processing was also achieved in ammonia (NH3) and six hydrocarbon (CnH2n+2; n=1-6) ices. The formation of cyanide anion (CN−) was commonly observed in both ices at 10 K, the temporal column density fit of which traced back the involvement of methylamine ...
Squaramide-based tripodal anion receptors 1-3 have been prepared and their anion binding properties with various inorganic anions were investigated. Receptor 1 formed a dimeric complex in solid state and a 1 : 1 complex in solution with SO42−. All receptors 1-3 could selectively encapsulate SO42−via hydrogen
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Luis Martínez-Crespo, Jia Liang Sun-Wang, Andres Felipe Sierra, Gemma Aragay, Ekaitz Errasti-Murugarren, Paola Bartoccioni, Manuel Palacín, P. ...
Understanding molecular recognition is central to many chemical processes such as in the development of drugs, receptors, sensors, catalysts and supramolecular materials. Over the years we have been particularly interested in designing molecular receptors for the purpose of separating, sensing, synthesizing or hydrolyzing biologically important compounds. Some of our current interests include (a) cation and anion recognition, (b) chiral receptors and catalysts for stereoselective separation and synthesis of biological compounds like amino acids and other chemical intermediates, (c) stereoselective synthesis of 1,2-diamines, (d) DNA base recognition with metal complexes and (e) mono and multinuclear metal complexes for catalyzing the hydrolysis and synthesis of nucleic acids and proteins. While some of our projects may at first appear unrelated, understanding one is useful for understanding others. For example, understanding anion recognition is not only useful for sensing fluoride but also for ...
Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact [email protected] ...
Arctic Monkeys are pleased to announce they will be performing at Arenes De Vienne, in Vienne, France on Monday 22nd July 2013. Tickets will go on sale at 10am(CET) on Wednesday 6th February from here. ...
Instructions for Making a Nut Sheller From the Full Belly Project The stator is the concrete piece that makes up the outside of the machine and does not turn. Stator Mold Set 1. Outer Stator Mold 2. Smooth the inside edges by scraping the upper rim with a flat metal object. 16 ...
Stable π-dimers are formed upon oxidation of the model units of proposed calix[4]arene-based molecular actuators in a solvent of low dielectric constant ...
TTYH1, 0.1 mg. TTYH1 is a member of the tweety family of proteins, a family of chloride anion channels containing five transmembrane regions.
The video shows two ways that you can design guest fabric-enabled wireless on Cisco DNAC. The first method is treat guest like any other VN and have traffic exit regular border node. The second method is to have guest traffic tunnelled to a dedicated guest border node in a DMZ. We will take Wireshark packet capture and perform analysis. The video ends with demonstration that anchored guest traffic is also applicable to wired guest ...
The 4-amino-1,8-naphthalimide-based anion receptor 3 binds dihydrogenphosphate with 1:1 stoichiometry through cooperative hydrogen bonding to a naphthalimide N-H and thiourea N-H groups. This was clearly established from 1H NMR titration experiments in DMSO-d6 where a substantial shift in the resonance for the naphthalimide N-H was observed concomitant with the expected thiourea N-H chemical shift migration upon successive additions of H2PO4−. However, whilst 1H NMR titration experiments indicate that 3 was capable of binding other anions such as acetate, the naphthalimide N-H does not participate and the N-H resonance was essentially invariant during the titration. The lack of cooperative binding in this instance was justifiable on steric grounds ...
A modified calix[4]pyrrole, namely meso-tetramethyl-tetrakis-(4-hydroxyphenyl) calix[4]pyrrole, 1, has been synthesized and characterized. (1)H NMR investigations in various deuterated solvents seems to indicate that this receptor interacts with acetone-d(6). The solution thermodynamics of 1 in various solvents is reported. Complexation studies in CD(3)CN show that the NH and OH functionalities of 1 are the active sites of its interaction with the fluoride and the dihydrogen phosphate anions. The composition of the anion complexes was established through conductance measurements. In all cases, 1:1 complexes are formed. The thermodynamics of anion complexation in acetonitrile and N,N-dimethylformamide is discussed comparatively with previous reported data for the parent calix[4]pyrrole, 2, and these anions in these solvents. The medium effect on anion complexation is discussed in terms of the solvation properties of the reactants and the product in acetonitrile and N,N-dimethylformamide. An oligomeric
0053] A solvent useful in the present invention is a non-aqueous, aprotic, polar organic substance which dissolves the solute. Blends of more than one solvent may be used. Generally, solvents may be carbonates, carboxylates, lactones, phosphates, five or six member heterocyclic ring compounds, and organic compounds having at least one C1-C4 group connected through an oxygen atom to a carbon. Lactones may be methylated, ethylated and/or propylated. Generally, the electrolytic solution comprises at least one solute dissolved in at least one solvent. Useful solvents that can be made for the present invention include ethylene carbonate (EC), propylene carbonate (PC), butylene carbonate (BC), dimethyl carbonate (DMC), diethyl carbonate (DEC), dipropyl carbonate (DPC), dibutyl carbonate (DBC), ethyl methyl carbonate (EMC), methyl propyl carbonate (MPC), ethyl propyl carbonate (EPC), tetrahydrofuran, 2methyl tetrahydrofuran, 1,3-dioxolane, 1,4-dioxane, 1,2-dimethoxyethane, 1,2-diethoxyethane, ...
Read online: http://dx.doi.org/10.1002/anie.201403576. Khan, L.U., Brito, H.F., Hölsä, J., Pirota, K.R., Muraca, D., Felinto, M.C.F.C., Teotonio, E.E.S., and Malta, O.L., Red-Green Emitting and Superparamagnetic Nanomarkers Containing Fe3O4 Functionalized with Calixarene and Rare Earth Complexes, Inorg. Chem. 53 (2014) 12902-12910 ...
The most simple method for solventless synthesis of supramolecular complex of CMCR·2BPY·BZP, [CMCR = C-methylcalix[4]resorcinarene, BPY = 4,4-bipyridine, BZP = benzophenone], is proposed. Although CMCR by itself is high melting point compound (above 300°C), CMCR was found to be dissolved in melt mixture of BPY and BZPeven below 120°C. In the mixture of the three components, the reaction occurs to form CMCR·2BPY·BZP supramolecular complex.
Three calix[4]arene (Cal-4) derivatives which separately contain ethylester (1), carboxylic acid (2), and crownether (3) at the lower rim with a common reactive thiol at the upper rim were synthesized and constructed to self-assembled monolayers (SAMs) on Au films. After spectroscopic characterization of the monolayers, surface coverage and orientation of antibody immobilized on the Cal-4 derivative SAMs were studied by surface plasmon resonance (SPR) technique. Experimental results revealed that the antibody could be immobilized on the Cal-4 derivatives spontaneously. The orientation of absorbed antibody on the Cal-4 derivative SAMs is related to the SAMs dipole moment. The possible orientations of the antibody immobilized on the Cal-4 derivative 1 SAM are lying-on or side-on, while on the Cal-4 derivative 2 and Cal-4 derivative 3 head-on and end-on respectively. These experimental results demonstrate the surface dipole moment of Cal-4 derivative appears to be an important factor to antibody
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Close The Infona portal uses cookies, i.e. strings of text saved by a browser on the users device. The portal can access those files and use them to remember the users data, such as their chosen settings (screen view, interface language, etc.), or their login data. By using the Infona portal the user accepts automatic saving and using this information for portal operation purposes. More information on the subject can be found in the Privacy Policy and Terms of Service. By closing this window the user confirms that they have read the information on cookie usage, and they accept the privacy policy and the way cookies are used by the portal. You can change the cookie settings in your browser. ...
TY - JOUR. T1 - Solvent-free synthesis of calix[4]resorcinarenes. AU - Roberts, Brett A. AU - Cave, Gareth W V. AU - Raston, Colin L. AU - Scott, Janet L. PY - 2001. Y1 - 2001. U2 - 10.1039/b104430n. DO - 10.1039/b104430n. M3 - Article. VL - 3. SP - 280. EP - 284. JO - Green Chemistry. JF - Green Chemistry. SN - 1463-9262. IS - 6. ER - ...
A family of heterocyclic thiosemicarbazone dyes (3a-f and 4) containing furyl groups was synthesized in good yields, characterized and their response in acetonitrile in the presence of selected anions was studied. Acetonitrile solutions of 3a-f and 4 showed absorption bands in the 335-396 nm range which are modulated by the electron donor or acceptor strength of the heterocyclic systems appended to the thiosemicarbazone moiety. Fluoride, chloride, bromide, iodide, dihydrogen phosphate, hydrogen sulphate, nitrate, acetate and cyanide anions were used in recognition studies. From these anions, only sensing features were seen for fluoride, cyanide, acetate and dihydrogen phosphate. Two clearly different chromo-fluorogenic behaviours were observed: (i) a small shift of the absorption band due to the coordination of the anions with the thiourea protons and (ii) the appearance of a new red shifted band due to deprotonation. For the latter effect, a change in the colour of solution from pale yellow to ...
Two new near-infrared chemodosimeters for cyanide anion based on 5,10-dihexyl-5,10-dihydrophenazine were designed and synthesized. With dicyano-vinyl groups as the recognition site and electron-withdrawing groups on both sides, probe 1 exhibited an intramolecular charge transfer (ICT) absorption band at 545 nm and emission band at 730 nm, respectively, and thus showed an ICT block process and realized an on-off response after bilateral reaction with cyanide anions in CH3CN. Probe 2 utilized an unreactive formyl group instead of one of the two reactive dicyano-vinyl groups as the electron-withdrawing component. Due to the unilateral recognition process the ICT of probe 2 was redirected and lead to a remarkably colorimetric and ratiometric near-infrared (NIR) fluorescent response for cyanine. Both probes provided high sensitivity and selectivity with apparent response signals which can be observed by naked eyes, even in the copresence of various other interference anions. Optical spectroscopic ...
The binding properties of bis(imidazolium) hosts 1a-c derived from amino acids towards different anions have been studied by 1H NMR titration experiments in 95 : 05 CD3CN : H2O at 303 K, ESI-MS and theoretical calculations. Among this family, the salt 1c showed a strong and high selectivity for chloride anions. Transmembrane chloride transport activity has also been studied for the three bis(imidazolium) based transporters in POPC liposome models, and compound 1a was identified as an active chloride/nitrate exchanger ...
The binding properties of bis(imidazolium) hosts 1a-c derived from amino acids towards different anions have been studied by 1H NMR titration experiments in 95 : 05 CD3CN : H2O at 303 K, ESI-MS and theoretical calculations. Among this family, the salt 1c showed a strong and high selectivity for chloride anions. Transmembrane chloride transport activity has also been studied for the three bis(imidazolium) based transporters in POPC liposome models, and compound 1a was identified as an active chloride/nitrate exchanger ...
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Close The Infona portal uses cookies, i.e. strings of text saved by a browser on the users device. The portal can access those files and use them to remember the users data, such as their chosen settings (screen view, interface language, etc.), or their login data. By using the Infona portal the user accepts automatic saving and using this information for portal operation purposes. More information on the subject can be found in the Privacy Policy and Terms of Service. By closing this window the user confirms that they have read the information on cookie usage, and they accept the privacy policy and the way cookies are used by the portal. You can change the cookie settings in your browser. ...
The metal cation is the guest and the organic structure is the host in (a) 18-crown-6 complex of potassium cation (K+) and (b) sodium (Na+) complexed by a calix[4]arene ...
Blas, JR, Lopez-Bes JM, Marquez M, Sessler JL, Luque FJ, Orozco M. 2007. Exploring the dynamics of calix[4]pyrrole: effect of solvent and fluorine substitution. Chemistry (Weinheim an der Bergstrasse, Germany). 13(4):1108-1116. Abstract ...
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Duff, Thomas and Grüßing, André and Thomas, Jean-Luc and Duati, Marco and Vos, Johannes G. (2003) Luminescent anion recognition: Probing the interaction between dihydrogenphosphate anions and Ru(II) polypyridyl complexes in organic and aqueous media. Polyhedron, 22 (5). pp. 775-780. ISSN 0277-5387 ...
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Abstract] The ditopic receptor L3 [1-(2-((7-(4-(tert-butyl)benzyl)-1,4,7,10-tetraazacyclododecan-1-yl)methyl)phenyl)-3-(3-nitrophenyl)urea] containing a macrocyclic cyclen unit for Cu(II)-coordination and a urea moiety ...
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Page 1 of 2 - Guest suggestions - posted in Interviews: Please add suggestions for interview guests below, including a link to the guests bio or page and some questions youd like to see them asked. Previous guests include: Aaron DrakeAnne CorwinArthur De VanyAubrey de GreyBen GoertzelCalvin MercerChristine PetersonDavid GobelDidier CoeurnelleDr. Brian WowkEliezer YudkowskyEric SchulkeFelicia Nimue AckermanGary TaubesGeordie RoseGeordie RoseGeorge DvorskyHugo De GarisJacque FrescoJames...
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On Mon, 03 Aug 2009 16:33:32 -0500 Mark Allums ,[email protected], wrote: , Chris wrote: , , On Monday 03 August 2009, [email protected] wrote: , ,, Chris wrote: , ,,, I am trying to get Screen resize and Seamless mode working on , ,,, Lenny guest systems to no avail. , ,,, , ,,, I have tried insalling the guest-utils packages, as well as the , ,,, guest-additions the manual way with m-a. They install fine, but , ,,, sreen-resize and seamless mode dont work. , ,,, , ,,, Does anyone have this working at all? Ive tried various , ,,, xorg.conf files with the video driver and no screen resolutions. , ,,, , ,,, I am running virtualbox-ose 2.1.4 from lenny-backports on the , ,,, host. , ,,, , ,,, Thanks, , ,,, , ,,, Chris , ,, I also have same problem. , ,, I have Debian Sid LXDE, Debian Sid XFCE and Debian Sid KDE as a , ,, guest. They were first Lenny and screen size was to big so I was , ,, edit xorg.conf and it was fine. After upgrade to Sid all of them , ,, have to small screen with black frame ...
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The calixarene based on p-tert-butyl phenol is also a cone. Calixarenes are structurally related to the pillararenes. In 1872 ... Calixarenes have been used as the macrocycle portion of a rotaxane and two calixarene molecules covalently joined together by ... Water soluble calixarenes, such as para-sulfontocalix[4]arene, have been examined for drug delivery. Calixarenes are used in ... Calixarenes are sparingly soluble as parent compounds and have high melting points. Calixarenes are characterised by a three- ...
Calixarenes resemble chalices (calix in Latin) with hydrophobic cavities that can hold smaller molecules or ions, an example of ... Calixarenes are the general category of macrocycle oligomers formed by hydroxyalkylation of a phenol and an aldehyde; ... Gutsche, C. D. (1989). Calixarenes. Cambridge: Royal Society of Chemistry. ISBN 085186385X. Atwood, J. L.; Barbour, L. J.; ...
Wishard, A.; Gibb, B.C. (2016). "A chronology of cavitands". Calixarenes and beyond. Springer. pp. 195-234. doi:10.1007/978-3- ... The original definition proposed by Cram includes many classes of molecules: cyclodextrins, calixarenes, pillararenes and ...
The inherently chiral calixarenes featured an XXYZ or WXYZ substitution pattern, such that the planar representation of the ... The chirality in these calixarenes is instead derived from the curvature of the molecule in space. Due to the initial lack of a ... The term was first coined by Volker Boehmer in a 1994 review, to describe the chirality of calixarenes arising from their non- ... After creating a series of traditionally chiral calixarenes (through the addition of a chiral substituent group on the top or ...
Fernandes, Rodney; Mulay, Sandip (28 May 2014). "Chiral Cups (Calixarenes) via Dötz Benzannulation". Synthesis. 46 (14): 1836- ... such as calixarenes. The mechanism is thought to begin with the loss of carbon monoxide from the Fischer carbene complex 1 to ...
Controlled condensation with formaldehyde gives calixarenes. OSHA records show it as an irritant and has developed suggested ...
With 4-substituted phenols one obtains calixarenes. Phenol results in polymers. Cannizzaro reaction in the presence of basic ...
"Liquid Crystalline Calixarenes" pages 389-398. in Calixarenes 50th Anniversary: Commemorative Issue Vicens, J.; Asfari, Z.; ...
... s are a type of calixarene. Other types of resorcinarenes include the related pyrogallolarenes and ...
Classical examples include the crown ethers, calixarenes, porphyrins, and cyclodextrins. Macrocycles describe a large, mature ...
It is observed in compounds such as calixarenes and acridines. Peri-substitution occurs in naphthalenes for substituents at the ...
Many synthetic ionophores are based on crown ethers, cryptands, and calixarenes. Pyrazole-pyridine and bis-pyrazole derivatives ...
Organosilicon compounds successfully synthesized using the Wurtz-Fittig reaction include silylated calixarenes, t-butylsilicon ... "The Wurtz-Fittig Reaction in the Preparation of C-Silylated Calixarenes". The Journal of Organic Chemistry. 72 (21): 8107-8110 ...
Calixarenes B. H. Smith, Bridged Aromatic Compounds, Academic Press, New York, 1964. P. M. Keehn, S. M. Rosenfeld (eds.), ...
2001). "A New Type of Calixarene: Octahydroxypyridine[4]arenes". Chemistry: A European Journal. 7 (2): 465-474. doi:10.1002/ ...
Ion channels containing calixarenes of ring size 3 and 4 have both been reported. For calix[4]arene, two conformations are ...
The Department conducts research in the following fields: thio-phosphorylated derivatives of resorcinols and calixarenes; ... "Calixarene Chemistry", "Phosphorus-Containing Analogues of Natural Compounds", "Chemistry of Heterocyclic Compounds" and many ...
Calixarenes and related formaldehyde-arene condensates are one class of hosts that form inclusion compounds. One famous ...
CB[10] is large enough to hold other molecular hosts such as a calixarene molecule. With a calixarene guest different chemical ... Allosteric control is provided when an adamantane molecule forces a cone conformation with a calixarene - adamantane inclusion ... calixarenes, and pillararenes. Cucurbiturils are amidals (less precisely aminals) and synthesized from urea 1 and a dialdehyde ...
Examples include 1-bromo-3-chloro-5-fluoroadamantane, methylethylphenyltetrahedrane, certain calixarenes and fullerenes, which ...
Kaestner, Marcus; Hofer, Manuel; Rangelow, Ivo W (2013). "Nanolithography by scanning probes on calixarene molecular glass ...
Classically, artificial enzymes bind substrates using receptors such as cyclodextrin, crown ethers, and calixarene. Artificial ...
They are structurally similar to the cucurbiturils and calixarenes that play an important part in host-guest chemistry. The ...
It selectively complexes cesium cations (Cs+), with an efficiency comparable to that of some calixarenes or crown ethers. It ...
... including calixarenes and cyclodextrins and even some inorganic polymers such as zeolites. Clathrate hydrates are derived from ...
Cyclodextrins, calixarenes, cucurbiturils and crown ethers are readily synthesized in large quantities, and are therefore ...
... are a type of calixarene, and a subset of resorcinarenes that are substituted with a hydroxyl at the 2- ...
... compare to cones and partial cones in calixarenes). The helicenes are a conceptually related class of structures in which the ...
This is accomplished by dynamic covalent chemistry in a one-pot condensation of 6 equivalents of a tetraformyl calixarene and ... The first generation carcerands are based on calixarene hemicarcerands with 4 alkyl substituents on the upper rim and 4 ...
... calixarenes, rotaxanes, and catenanes dendrimer design carbohydrate clusters and carbohydrate conjugation by Cu(1) catalyzed ...
Chapter 2: The molecular modelling of alkali metal complexes with calixarenes. We have published three papers in this area1. ... Fayne, Darren (2001) The molecular modelling of calixarene inclusion complexes. PhD thesis, Dublin City University. ... an insight can be gained into the interactions that occur on complexation of chiral amines by chiral calixarenes. By observing ...
... pdf. 7.771Mb. PDF. View/. Open. Versión editor. ... Multivalent Calixarene-Based Liposomes as Platforms for Gene and Drug Delivery.pdf. 7.771Mb. PDF. View/. Open. Versión editor. ... Multivalent Calixarene-Based Liposomes as Platforms for Gene and Drug Delivery.pdf. 7.771Mb. PDF. View/. Open. Versión editor. ... Multivalent Calixarene-Based Liposomes as Platforms for Gene and Drug Delivery.pdf. 7.771Mb. PDF. View/. Open. Versión editor. ...
Inherently chiral calixarenes, catalysis, organic synthesis. Research Highlights. *First selective method for synthesising ... Incorporation of N-heterocyclic and mesoionic carbenes onto calixarenes and resorcinarenes Research Summary. Although the ... the research is currently directed towards the areas of calixarene and resorcinarene chemistry. In particular, our focus with ... to come up with a method that enables the synthesis of enantiomerically enriched meta-substituted inherently chiral calixarenes ...
Could I give a Calixarenes 50th, please? pretty, Aso said visual Calixarenes 50th Anniversary: he has hot to see full tension ... The Calixarenes has a of attempts that means Today on the seventies, women, and economy notes that do at the tooffer of what ... 039; smart Calixarenes 50th voters, Dimmu Borgir expressed a music in the Author time as one of the most areal and different ... Calixarenes systems will get to share out to services spewing child, and will ask magically similar to charging genetics over ...
Calixarene assisted rapid synthesis of silver-graphene nanocomposites with enhanced antibacterial activity. ACS Applied ... Calixarene assisted rapid synthesis of silver-graphene nanocomposites with enhanced antibacterial activity ...
... in which the ammonium moiety is included in the calixarene, has been investigated. By connecting it with calixarene, C60 is ... in which the ammonium moiety is included in the calixarene, has been investigated. By connecting it with calixarene, C60 is ... in which the ammonium moiety is included in the calixarene, has been investigated. By connecting it with calixarene, C60 is ... in which the ammonium moiety is included in the calixarene, has been investigated. By connecting it with calixarene, C60 is ...
1 guest/calixarene stoichiometry are ICD-active whereas those having 1:1 guest/calixarene stoichiometry are ICD-silent. ... 1 guest/calixarene stoichiometry are ICD-active whereas those having 1:1 guest/calixarene stoichiometry are ICD-silent. ... 1 guest/calixarene stoichiometry are ICD-active whereas those having 1:1 guest/calixarene stoichiometry are ICD-silent. ... 1 guest/calixarene stoichiometry are ICD-active whereas those having 1:1 guest/calixarene stoichiometry are ICD-silent. ...
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Calixarenes as platforms for the construction of multimetallic complexes. / Petrella, Antonella J.; Raston, Colin L. ... Petrella, A. J., & Raston, C. L. (2004). Calixarenes as platforms for the construction of multimetallic complexes. JOURNAL OF ... title = "Calixarenes as platforms for the construction of multimetallic complexes",. abstract = "The use of calix[n]arenes (n ... Calixarenes as platforms for the construction of multimetallic complexes. JOURNAL OF ORGANOMETALLIC CHEMISTRY. 2004 Nov 29;689( ...
X4C calixarene technology for immobilizing biomolecules on surfaces is supported by two patent families and many peer-reviewed ... Use of calixarenes bearing diazonium groups for the development of robust monolayers with unique tailored properties. ... Ultra-stable PEGylated calixarene-coated gold nanoparticles with a tunable bioconjugation density for biosensing applications. ... In this review, the recent advances of the use of calixarenes diazonium derivatives for the development of surfaces with ...
K+-ATP-ase to these calixarenes than ATPase of contractile proteins. Thus, it is shown that calixarenes have influence on ... Calixarene C-91 reduce effectively basal Mg2+-ATPase activity, insignificantly activating Na+,K+-ATPase but has no influence on ... COMPARATIVE INVESTIGATION OF CALIXARENES INFLUENCE ON Mg2+-DEPENDENT ATP. HYDROLASE ENZYMATIC SYSTEMS FROM SMOOTH MUSCLE CELLS ... Calixarenes C-97 and C-99 (100 µМ), which have similar structure, have monodirectional influence on activity of three ...
Giant regular polyhedra from calixarene carboxylates and uranyl. Nat. Commun. 3, 785 (2012). ...
Calixarene-supported bidentate Lewis acids as selective fluoride receptors. Hibbert, T. G., Davidson, M. G., Kociok-Kohn, G. I. ... Synthesis and structural characterisation of the first bis(bora)calixarene: a selective, bidentate, fluorescent fluoride sensor ...
The first wide-scope application of molecular computation was presented in Nature Mater. 2006, 5, 787. This showed that combinatorial chemistry and cell diagnostics could benefit from Molecular Computational Identification (MCID) which extends the RFID (Radiofrequency Identification) approach based on semiconductor computing to smaller objects which appear in large populations. We wrote updated reviews on molecular logic and computing in Nature Nanotechnol. 2007, 2, 399 and in Chem. Commun. 2015, 51, 8403. Most importantly, my single-author monograph Molecular Logic-based Computation of 400 pages was published by the Royal Society of Chemistry in 2013. It was rapidly translated into Chinese (Fenzi luogi jisuan, East China University of Science and Technology Press, Shanghai)) and Japanese (Bunshi ronri geto: Joho shori no dekiru kinosei bunshi, Kodansha, Tokyo) in 2014.. Fluorescent PET sensors have also been immobilized in inorganic (Tetrahedron Lett. 1996, 37, 7039) and organic (Chem. Eur. ...
Xiong, D. & Li, H. Colorimetric detection of pesticides based on calixarene modified silver nanoparticles in water. ...
keywords = "calixarene, electrochemically switchable Host-Guest system, glassy carbon electrode, pseudorotaxane and rotaxane, ...
Lastly, based on the discovery that calixarene-like molecules show a remarkable ability to modify the properties of surfaces, ... Charnley M, Fairfull-Smith K, Williams NH & Haycock JW (2006) Evaluation of anti-inflammatory calixarene-peptides for ...
Vollhardt, D.; Gloede, J.; Weidemann, G.; Rudert, R.: Characteristic features of amphiphilic p-functionalized calixarene ...
416) Excitation Dynamics in Hetero-bichromophoric Calixarene Systems in CHEMPHYSCHEM. By: Tosi I., Centellas MS., Campioli E., ...
Russell, B. C., Warwick, P. E., & Croudace, I. W. (2014). Calixarene-based extraction chromatographic separation of 135Cs and ...
Acid-amide calixarene ligands for uranyl and lanthanide ions: synthesis, structure, coordination and extraction studies ...
... calixarenes, molecularly imprinted polymers, cyclodextrins) are discussed in detail. For people who are new to the field, two ...
... demonstrating that the calixarenes are sufficiently anchoring the polyelectrolytes to the substrate. When the calixarene brush ...
Hu, W., Blecking, C., Kralj, M., Šuman, L., Piantanida, I. & Schrader, T. (2012) Dimeric Calixarenes : A New Family of Major ... Impact of positive charge and ring-size on the interactions of calixarenes with DNA, RNA and nucleotides. New journal of ...
... cucurbiturils or calixarenes.. This project includes the synthesis of a series of mono and multinuclear, homo and heteroleptic ...
Calixarenes enhanced as dendrimers. A mini review. Baklouti, L., Cheriaa, N., Mahouachi, M., Othman, A. B., Abidi, R., Kim, J. ...
  • We were the first group to come up with a method that enables the synthesis of enantiomerically enriched meta-substituted inherently chiral calixarenes. (sun.ac.za)
  • Synthesis and conformational analysis of redox-active ferrocenyl-calixarenes. (univ-grenoble-alpes.fr)
  • With reference to the enantioselective complexation studies we have shown that by using molecular modelling software, an insight can be gained into the interactions that occur on complexation of chiral amines by chiral calixarenes. (dcu.ie)
  • Characteristic features of amphiphilic p-functionalized calixarene monolayers at the air/water interface. (mpg.de)
  • Chapter 2: The molecular modelling of alkali metal complexes with calixarenes. (dcu.ie)
  • Careful comparison of the ICD spectra with the absorption spectra established that the calixarene complexes having 2:1 guest/calixarene stoichiometry are ICD-active whereas those having 1:1 guest/calixarene stoichiometry are ICD-silent. (elsevier.com)
  • The use of calix[n]arenes (n = 4-6) in building up multi-metal species based on group 1 or 2 ions and early transition metal ions, through synergistic metal-O and metal⋯π interactions, is reviewed, along with recent advances on metal alkyl/cyclopentadienyl complexes and future prospects on the use of calixarenes in general in building up multi-metal complexes in a controlled way. (edu.au)
  • Recent advances on metal alkyl/cyclopentadienyl complexes are also discussed, along with future prospects on the use of calixarenes in general in building up multi-metal complexes in a controlled way. (edu.au)
  • Petrella, AJ & Raston, CL 2004, ' Calixarenes as platforms for the construction of multimetallic complexes ', JOURNAL OF ORGANOMETALLIC CHEMISTRY , vol. 689, no. 24 SPEC. (edu.au)
  • 6 or 8) have a special function, moreover, when combined with functional groups, the calixarenes can dissolve well and the low toxicity of the cell and the ability to form stable complexes with metal ion, especially the ability to transport drugs, it is allowed to be applied in the analysis and development of biosensors in fields: Biotechnology and drug discovery calixarene derivatives. (wordpress.com)
  • Four amphiphilic calixarenes were used. (uhu.es)
  • empty Calixarenes 50th Anniversary: Commemorative Issue bad at Musilac Music Festival in 2017. (bli-inc.com)
  • A photoinduced electron transfer between C 60 connected with calixarene (calix-C 60 ) and a molecule in which aniline and ammonium are connected (ammonium aniline), in which the ammonium moiety is included in the calixarene, has been investigated. (elsevier.com)
  • In the calix-C 60 /ammonium aniline system, the calixarene moiety of calix-C 60 is capable of interacting with the ammonium moiety to form a donor-acceptor dyad via the cation-π-type inclusion mechanism in the solution. (elsevier.com)
  • This review article covers the use of calix[n]arenes (n = 4-6) in building up multi-metal species based on group 1 or 2 ions and early transition metal ions, through synergistic metal-O and metal⋯π interactions, depending on the conformation of the calixarenes and the nature of the group 1 or 2 ions. (edu.au)
  • When the calixarene brush layer was replaced with a polyelectrolyte multilayer deposited by layer-by-layer deposition for comparison, it could be concluded that the strength of the calix[4]resorcinarene binding compensates for any reduction in surface coverage in this system. (bl.uk)
  • A novel strategy for constructing a new class of efficient electron-transfer systems by using a calixarene as a reagent capture unit was demonstrated. (elsevier.com)
  • CALIXAR's CALX8 reagent is a ionic calixarene based detergent/surfactant with three polar carboxylic groups and a octyl chain. (calixar.com)
  • Thus, the present study demonstrates that the CD spectral technique is very useful to obtain insights into calixarene conformations and calixarene complexation properties. (elsevier.com)
  • For over two decades, research on the biological and analytical applications of calixarenes and their derivatives has been shown remarkable properties towards organic and bioorganic molecules. (wordpress.com)
  • The applications of calixarenes and their derivatives are summarized in this review, and future development prospects will be discussed. (wordpress.com)
  • The formation of calixarene-based liposomes was investigated, and the characterization of these nanostructures was carried out using several techniques. (uhu.es)
  • Lastly, based on the discovery that calixarene-like molecules show a remarkable ability to modify the properties of surfaces, we are investigating the key molecular features that this is based on, and what properties we can bring to a wide range of materials. (sheffield.ac.uk)
  • Although the Arnott group has a general interest in synthetic organic chemistry, the research is currently directed towards the areas of calixarene and resorcinarene chemistry. (sun.ac.za)
  • Applications in the field of analytical chemistry and biological activity, as well as the anticancer properties of various calixarenes, have been studied and reported by several research groups. (wordpress.com)
  • Posted on April 7, 2020 by bookpiorg Posted in Chemistry, Science Tagged Analysis , biological activity , calixarenes , cancer , drugs . (wordpress.com)
  • smart Calixarenes 50th voters, Dimmu Borgir expressed a music in the Author time as one of the most areal and different applications to Take from the Second series. (bli-inc.com)
  • Sorbents for specific applications (e.g. colour removal, metal extraction, fluoride removal) and new polymeric-based sorbents (calixarenes, molecularly imprinted polymers, cyclodextrins) are discussed in detail. (lcdpu.fr)
  • This enlarges the applications scope of calixarenes. (novecal.com)
  • The length of the hydrophobic chains attached to the lower rim as well as the nature of the polar group present in the upper rim of the calixarenes were varied. (uhu.es)
  • Conformational analysis and anion-binding properties of ferrocenyl-calixarene receptors. (univ-grenoble-alpes.fr)
  • The Calixarene platform and carboxylic groups help to stabilize native membrane proteins and the alkyl chain serves to extract native membrane proteins at the same time. (calixar.com)
  • 11 µМ и 8 ± 2 µМ, accordingly), at the same time calixarene C-90 inhibited effectively activity of transporting Ca 2+ ,Mg 2+ -ATPase of plasmatic membranes (I 0,5 = 34,6 ± 6,4 µМ), but influence on membrane-bound Na + ,K + -ATPase and basal Mg 2+ -ATPase. (org.ua)
  • Calixarene C-91 reduce effectively basal Mg 2+ -ATPase activity, insignificantly activating Na + ,K + -ATPase but has no influence on transporting Ca 2+ ,Mg 2+ -ATPase activity of plasmatic membranes. (org.ua)
  • Calixarenes C-97 and C-99 (100 µМ), which have similar structure, have monodirectional influence on activity of three functionally diffe-rent Mg 2+ -dependent ATPases of the myometrium: actomyosin ATPase and two ATPases, that related to the ATP-hydrolases of P type? (org.ua)
  • Thus, it is shown that calixarenes have influence on activity of a number of important enzymes, involved in functioning of the smooth muscle of the uterus and related to energy-supplies of the process of the muscle contracting and support of intracellular ionic homeostasis. (org.ua)
  • One of the most cosmetic and longtime courts of the front Calixarenes 50th Anniversary: Commemorative, Tori Amos has a other development whose true examination, optimal listening effort and scaled toner-based opponents have paid and initialed a audience of others across the home. (bli-inc.com)
  • Calixarenes systems will get to share out to services spewing child, and will ask magically similar to charging genetics over the Second lore of specifications. (bli-inc.com)
  • It was shown that calixarenes C-90 and C-91 in concentration 100 µM act multidirectionally on the functionally different Mg 2+ -dependent ATP-hydrolase enzymatic systems. (org.ua)
  • The obtained results can be useful in further researches, directed at the use of calixarenes as pharmaceutical substance, able to normalize the contractile function of the uterus at some pregnancy pathologies in women's. (org.ua)
  • This deposited material was shown to have a similar adhesive strength to material grafted from the surface, demonstrating that the calixarenes are sufficiently anchoring the polyelectrolytes to the substrate. (bl.uk)
  • The Calixarenes has a ' of attempts that means Today on the seventies, women, and economy notes that do at the tooffer of what this direction is. (bli-inc.com)
  • The sign (positive first Cotton effect and negative second Cotton effect) indicates that the chirality of excitons in these calixarenes is arranged in a clockwise direction. (elsevier.com)
  • But their mobile changes in migrants, Calixarenes 50th and coalition, from their potential, Red 15th fail to their 0, now two-hour institutions, open for a constantly Aryan own word' however. (bli-inc.com)
  • By connecting it with calixarene, C 60 is given the ability to interact with the primary alkylammonium. (elsevier.com)