Phenolic metacyclophanes derived from condensation of PHENOLS and ALDEHYDES. The name derives from the vase-like molecular structures. A bracketed [n] indicates the number of aromatic rings.
Organic compounds composed exclusively of carbon and hydrogen where no carbon atoms join to form a ring structure.
The facilitation of biochemical reactions with the aid of naturally occurring catalysts such as ENZYMES.
An enzyme of the hydrolase class that catalyzes the reaction of triacylglycerol and water to yield diacylglycerol and a fatty acid anion. It is produced by glands on the tongue and by the pancreas and initiates the digestion of dietary fats. (From Dorland, 27th ed) EC 3.1.1.3.
Cyclic compounds with a ring size of approximately 1-4 dozen atoms.
Nanometer-scale composite structures composed of organic molecules intimately incorporated with inorganic molecules. (Glossary of Biotechnology and Nanobiotechology Terms, 4th ed)
The study of the energy of electrons ejected from matter by the photoelectric effect, i.e., as a direct result of absorption of energy from electromagnetic radiation. As the energies of the electrons are characteristic of a specific element, the measurement of the energy of these electrons is a technique used to determine the chemical composition of surfaces.
An allotropic form of carbon that is used in pencils, as a lubricant, and in matches and explosives. It is obtained by mining and its dust can cause lung irritation.
Method of using a polycrystalline powder and Rietveld refinement (LEAST SQUARES ANALYSIS) of X-RAY DIFFRACTION or NEUTRON DIFFRACTION. It circumvents the difficulties of producing single large crystals.
The scattering of x-rays by matter, especially crystals, with accompanying variation in intensity due to interference effects. Analysis of the crystal structure of materials is performed by passing x-rays through them and registering the diffraction image of the rays (CRYSTALLOGRAPHY, X-RAY). (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Characteristics or attributes of the outer boundaries of objects, including molecules.
The lipid- and protein-containing, selectively permeable membrane that surrounds the cytoplasm in prokaryotic and eukaryotic cells.
Unstriated and unstriped muscle, one of the muscles of the internal organs, blood vessels, hair follicles, etc. Contractile elements are elongated, usually spindle-shaped cells with centrally located nuclei. Smooth muscle fibers are bound together into sheets or bundles by reticular fibers and frequently elastic nets are also abundant. (From Stedman, 25th ed)
The processes whereby the internal environment of an organism tends to remain balanced and stable.
A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.
Contractile tissue that produces movement in animals.
A subtype of striated muscle, attached by TENDONS to the SKELETON. Skeletal muscles are innervated and their movement can be consciously controlled. They are also called voluntary muscles.
A disaccharide consisting of one galactose and one glucose moiety in an alpha (1-6) glycosidic linkage.
Positively charged atoms, radicals or groups of atoms which travel to the cathode or negative pole during electrolysis.
Positively charged atoms, radicals or groups of atoms with a valence of plus 2, which travel to the cathode or negative pole during electrolysis.
The knowledge or perception that someone or something present has been previously encountered.
Positively charged atoms, radicals or group of atoms with a valence of plus 1, which travel to the cathode or negative pole during electrolysis.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
A 20-carbon dibenz(de,kl)anthracene that can be viewed as a naphthalene fused to a phenalene or as dinaphthalene. It is used as fluorescent lipid probe in the cytochemistry of membranes and is a polycyclic hydrocarbon pollutant in soil and water. Derivatives may be carcinogenic.
Protective measures against unauthorized access to or interference with computer operating systems, telecommunications, or data structures, especially the modification, deletion, destruction, or release of data in computers. It includes methods of forestalling interference by computer viruses or so-called computer hackers aiming to compromise stored data.
The privacy of information and its protection against unauthorized disclosure.
The state of being free from intrusion or disturbance in one's private life or affairs. (Random House Unabridged Dictionary, 2d ed, 1993)
A short thick vein formed by union of the superior mesenteric vein and the splenic vein.

Sulphonic acid derivatives as probes of pore properties of volume-regulated anion channels in endothelial cells. (1/86)

1. We have used the whole-cell patch-clamp technique to study the effects of 4-sulphonic-calixarenes and some other poly-sulphonic acid agents, such as suramin and basilen blue, on volume-regulated anion channel (VRAC) currents in cultured endothelial cells (CPAE cells). 2. The 4-sulphonic-calixarenes induced a fast inhibition at positive potentials but were ineffective at negative potentials. At small positive potentials, 4-sulphonic-calix[4]arene was a more effective inhibitor than 4-sulphonic-calix[6]arene and -calix[8]arene, which became more effective at more positive potentials. 3. Also suramin and basilen blue induced a voltage dependent current inhibition, reaching a maximum around +40 mV and declining at more positive potentials. 4. The voltage dependence of inhibition was modelled by assuming that these negatively charged molecules bind to a site inside VRAC that senses a fraction delta of the applied electrical field, ranging beween 0.16 to 0.32. 4-Sulphonic-calix[4]arene, suramin and basilen blue bind and occlude VRAC at moderate potentials, but permeate the channel at more positive potentials. 4-Sulphonic-calix[6]arene and -calix[8]arene however do not permeate the channel. From the structural information of the calixarenes, we estimate a lower and upper limit of 11*12 and 17*12 A2 respectively for the cross-sectional area of the pore.  (+info)

Anatomy, physiology, and synaptic responses of rat layer V auditory cortical cells and effects of intracellular GABA(A) blockade. (2/86)

The varied extracortical targets of layer V make it an important site for cortical processing and output, which may be regulated by differences in the pyramidal neurons found there. Two populations of projection neurons, regular spiking (RS) and intrinsic bursting (IB), have been identified in layer V of some sensory cortices, and differences in their inhibitory inputs have been indirectly demonstrated. In this report, IB and RS cells were identified in rat auditory cortical slices, and differences in thalamocortical inhibition reaching RS and IB cells were demonstrated directly using intracellular GABA(A) blockers. Thalamocortical synaptic input to RS cells was always a combination of excitation and both GABA(A) and GABA(B) inhibition. Stimulation seldom triggered a suprathreshold response. IB cell synaptic responses were mostly excitatory, and stimulation usually triggered action potentials. This apparent difference was confirmed directly using intracellular chloride channel blockers. Before intracellular diffusion, synaptic responses were stable and similar to control conditions. Subsequently, GABA(A) was blocked, revealing a cell's total excitatory input. On GABA(A) blockade, RS cells responded to synaptic stimulation with large, suprathreshold excitatory events, indicating that excitation, while always present in these cells, is masked by GABA(A). In IB cells that had visible GABA(A) input, it often masked an excitatory postsynaptic potential (EPSP) that could lead to additional suprathreshold events. These findings indicate that IB cells receive less GABA(A)-mediated inhibitory input and are able to spike or burst in response to thalamocortical synaptic stimulation far more readily than RS cells. Such differences may have implications for the influence each cell type exerts on its postsynaptic targets.  (+info)

Permeabilization via the P2X7 purinoreceptor reveals the presence of a Ca2+-activated Cl- conductance in the apical membrane of murine tracheal epithelial cells. (3/86)

Calcium-activated Cl(-) secretion is an important modulator of regulated ion transport in murine airway epithelium and is mediated by an unidentified Ca(2+)-stimulated Cl(-) channel. We have transfected immortalized murine tracheal epithelial cells with the cDNA encoding the permeabilizing P2X(7) purinoreceptor (P2X(7)-R) to selectively permeabilize the basolateral membrane and thereby isolate the apical membrane Ca(2+)-activated Cl(-) current. In P2X(7)-R-permeabilized cells, we have demonstrated that UTP stimulates a Cl(-) current across the apical membrane of CF and normal murine tracheal epithelial cells. The magnitude of the UTP-stimulated current was significantly greater in CF than in normal cells. Ion substitution studies demonstrated that the current exhibited a permselectivity sequence of Cl(-) > I(-) > Br(-) > gluconate(-). We have also determined a rank order of potency for putative Cl(-) channel blockers: niflumic acid > or = 5-nitro-2-(3-phenylpropylamino)benzoic acid > 4, 4'-diisothiocyanostilbene-2,2'-disulfonate > glybenclamide >> diphenlyamine-2-carboxylate, tamoxifen, and p-tetra-sulfonato-tetra-methoxy-calix[4]arene. Complete characterization of this current and the corresponding single channel properties could lead to the development of a new therapy to correct the defective airway surface liquid in cystic fibrosis patients.  (+info)

Emergent mechanical properties of self-assembled polymeric capsules. (4/86)

Synthetic self-assembled systems combine responsiveness and reversibility with the ability to perform chemical tasks such as molecular recognition and catalysis. An unmet challenge is the construction of polymeric materials that, like nature's tubulin, are simultaneously reversible and capable of useful physical tasks. We report here a class of reversibly formed polymers that show covalent-polymer mechanical integrity in solution and in the solid state. Non-Newtonian, polymeric behavior is observed despite the low molecular weight of the individual subunits and the seemingly weak forces holding the assemblies together. These polymers assemble through self-complementary hydrogen bonding and by physical encapsulation of small molecules; accordingly, the emergent macroscopic structure and function can be controlled by appropriate chemical signals.  (+info)

An improved Na+-selective microelectrode for intracellular measurements in plant cells. (5/86)

The high background K+ concentration in plant cells is a problem for intracellular measurements of Na+ using ion-selective microelectrodes. The discrimination between Na+ and K+ of the microelectrode ionophore molecule limits the usefulness of this technique. A new Na+-selective microelectrode with an ionophore incorporating a tetramethoxyethyl ester derivative of p-t-butyl calix[4]arene has been developed. Microelectrodes made with this new sensor have superior selectivity for Na+ over K+ resulting in a lower limit of detection when compared with microelectrodes made using a commercially available ionophore (ETH227). Both types of microelectrodes were insensitive to changes in ionic strength and physiological ranges of pH, but only the calixarene-based electrodes showed no protein interference. To test the suitability of the calixarene-based microelectrodes for measurements in plants, they were used to measure Na+ in epidermal cells in the zone 10-20 mm from the root apex of barley (Hordeum vulgare L.). Seedlings were grown in a nutrient solution containing 200 mM NaCl for 1-6 d. The range of intracellular Na+ activity (a(Na)) measured varied from < or =0.1 mM (limit of detection) to over 100 mM, and these values increased significantly with time. The membrane potential (E(m)) of these cells was variable, but the values became significantly more negative with time, although there was no significant correlation between E(m) and a(Na). These intracellular measurements could not be separated into distinct populations that might be representative of subcellular compartments.  (+info)

Interchain hydrogen-bonding interactions may facilitate translocation of K+ ions across the potassium channel selectivity filter, as suggested by synthetic modeling chemistry. (6/86)

A 4-fold symmetric arrangement of TVGYG polypeptides forms the selectivity filter of the K+ channel from Streptomyces lividans (KcsA). We report the synthesis and properties of synthetic models for the filter, p-tert-butyl-calix[4]arene-(OCH(2)CO-XOBz)(4) (X = V, VG, VGY), 1-3. The first cation (Na+, K+) binds to the four -[OCH(2)CO]- units, a region devised to mimic the metal-binding site formed by the four T residues in KcsA. NMR studies reveal that cations and valine amide protons compete for the carbonyl oxygen atoms, converting NH(Val)...O=C hydrogen bonds to M+ ...O=C bonds (M+ = Na+ or K+). The strength of these interchain NH(Val)...O=C hydrogen bonds varies in the order 3 > 2 > 1. We propose that such interchain H-bonding may destabilize metal binding in the selectivity filter and thus help create the low energy barrier needed for rapid cation translocation.  (+info)

Facile formation of chiral calixarene analogs incorporating cystine peptide into the macrocyclic ring. (7/86)

Chiral calixarene analogs incorporating cystine peptide into their macrocyclic ring were easily prepared by the cyclization reactions of bis(chloromethyl)phenol-formaldehyde oligomers with cystine peptides in moderate yields. Circular dichroism (CD) spectra indicated the existence of the transmission of the chirality from peptide unit to phenol-formaldehyde oligomer moiety.  (+info)

Cytosine substituted calix[4]pyrroles: neutral receptors for 5'-guanosine monophosphate. (8/86)

The synthesis and characterization of two cytosine-substituted calix[4]pyrrole conjugates, bearing the appended cytosine attached at either a beta- or meso-pyrrolic position, is described. These systems were tested as nucleotide-selective carriers and as active components of nucleotide-sensing ion-selective electrodes at pH 6.6. Studies of carrier selectivity were made using a Pressman-type model membrane system consisting of an initial pH 6.0 aqueous phase, an intervening dichloromethane barrier containing the calix[4]pyrrole conjugate, and a receiving basic aqueous phase. Good selectivity for the Watson-Crick complementary nucleotide, 5'-guanosine monophosphate (5'-GMP), was seen in the case of the meso-linked conjugate with the relative rates of through-membrane transport being 7.7:4.1:1 for 5'-GMP, 5'-AMP, and 5'-CMP, respectively. By contrast, the beta-substituted conjugate, while showing a selectivity for 5'-GMP that was enhanced relative to unsubstituted calix[4]pyrrole, was found to transport 5'-CMP roughly 4.5 times more quickly than 5'-GMP. Higher selectivities were also found for 5'-CMP when both the beta- and meso-substituted conjugates were incorporated into polyvinyl chloride membranes and tested as ion selective electrodes at pH 6.6, whereas near-equal selectivities were observed for 5'-CMP and 5'-GMP in the case of unsubstituted calix[4]pyrroles. These seemingly disparate results are consistent with a picture wherein the meso-substituted cytosine calix[4]pyrrole conjugate, but not its beta-linked congener, is capable of acting as a ditopic receptor, binding concurrently both the phosphate anion and nucleobase portions of 5'-GMP to the calixpyrrole core and cytosine "tails" of the molecule, respectively, with the effect of this binding being most apparent under the conditions of the transport experiments.  (+info)

Our Viewpoints focus the spotlight on significant impacts and breakthroughs resulting from ChemComm articles in the last century, and can serve as catalysts for active discussion and inspiration within the community.. Earlier this year, Jack Harrowfields Viewpoint focussing on the 1985 contribution of Tony McKerveys group to the field of calixarenes and cations generated an enthusiastic response, including suggestions on other articles that were also felt to have played a seminal role in calixarene chemistry. As a result, we have recently published an alternative Viewpoint by Alessandro Casnati on the impact of Communications published (in 1983 and 1984) by the group of Rocco Ungaro and Andrea Pochini.. Read both Viewpoints now and see the impact these groundbreaking Comms created:. ...
Calixarenes bear a fascinating class of macrocycles that have served broadly in molecular recognition and supramolecular chemistry. These, supramolecular structures have been utilized in several different directions ranging from catalysis to therapy.
Calix[4]tetra-diazonium cations generated in situ from the corresponding tetra-anilines were electrografted on gold and carbon substrates. The well-preorganized macrocyclic structure of the calix[4]arene molecules allows the formation of densely packed monolayers. Through adequate decoration of the small rim of the calixarenes, functional molecules can then be introduced on the immobilized calixarene subunits, paving the way for an accurate spatial control of the chemical composition of a surface at molecular level. One cool experiment is determination of surface coverage by functionalizing the electrode with COOH terminated calixarenes and then coupling on Fc moieties and doing CV ...
We investigated the influence of calixarene C-90 and IPT-35 on plasma membrane Ca2+- pumping АТРase (PMCA), intracellular calcium homeostasis and myometrium smooth muscle strain contractions. It has been shown that both effectors (100 μM) affect PMCA enzymatic activity: calixarene C-90 inhibits it b …
TY - CONF. T1 - Development of a time-resolved immunoassay delay system based on lanthanide ions complexed by calixarene derivatives. AU - Steemers, F.J.. AU - Rudkevich, D.M.. AU - van der Tol, E.B.. AU - Verboom, Willem. AU - Verhoeven, J.W.. AU - Reinhoudt, David. PY - 1994/10/10. Y1 - 1994/10/10. M3 - Poster. T2 - Bijeenkomst SON-werkgemeenschap Organische Synthese 1994. Y2 - 10 October 1994 through 11 October 1994. ER - ...
Authors: MUSTAFA YILMAZ, SERKAN ERDEMİR Abstract: Calixarene-based molecular receptors have been a widely developing area in material science and technology for the last few decades. Due to their bowl-shaped geometry, calixarene macrocycles are used as hosts allowing organic and inorganic guests to coordinate/sorb onto their cavity. This work briefly reviews the recent development of calixarenes. Keywords: Calixarene, receptor, host-guest, drugs, chiral, lipase Full Text: PDF ...
Due to their recognition properties and efficiency for the detection of toxic metals, calixarenes have already found applications in the design of chemical sensors based on using an electrochemical transduction. In this study, a new chromogenic azo-calix[4]arene derivative was deposited on gold electrode by spin coating to develop a new electrochemical sensor. Adhesion and morphological properties of the membrane have been firstly developed using contact angle measurements and scanning electronic microscopy (SEM) respectively. Electrochemical impedance spectroscopy (EIS) is used to study the response of the calixarenes membrane in contact with aqueous solutions of various metallic cations. The impedance behavior of the structures has been modeled by an equivalent circuit using the Z-View software. This technique has shown a selective response of this membrane towards Hg(2+), Ni(2+) and Eu(3+). The differences in selectivity are found to be represented by variations in the resistance of the membrane (R(m
ENGLISH ABSTRACT: Resorcinarenes are macrocyclic products formed from the condensation of aldehydes (aliphatic or aromatic) and resorcinol and have been used in a wide range of applications since their first synthesis. Applications include: HPLC stationary phases for the separation of pyrimidine bases, racemic drugs and isomers, the selective extractions of lanthanides and actinides, as molecular receptors, catalysis, NMR chiral shift agents, GC separations and as starting materials for the synthesis of macrocyclic compounds (e.g. cavitands and carcerands) to name but a few. The use of resorcinarenes in catalysis is still quite new and unexplored, while catalysis using calix[4]arenes, a related macrocycle, has been widely studied. In this thesis it was attempted to synthesise a C2v symmetric resorcinarene precursor that could be further functionalised to form distal bidentate ligands for coordination to transition metals. These compounds would then ultimately be used in catalytic testing, ...
On 13th February 2017, the half-brother of the North-Korean dictator Kim Jong-un was poisoned, supposedly with one of the deadliest known chemicals, namely, the nerve agent VX (O-ethyl S- methylphosphonothioate). This poison is so effective that contamination of the skin with only ca.
Following an introduction on calixarene chemistry and their metal-ion complexes including some of their applications, the aim of the work are described. Thus this thesis concentrates on the synthesis and characterisation of two new lower rim calix(4)arene derivatives containing mixed pendent arms as well as an investigation on the solution properties of their metal-ion complexes. Macrocycles namely, 5, 11, 17, 23 tetrakis (1, 1 dimethylethyl) 25, 27- bis [(2-methylthio) ethoxy] 26, 28-bis [2- pyridyl methyloxy] calix(4)arene, L1 and 5, 11, 17, 23 tetrakis (1, 1 dimethylethyl) 25, 27- bis [(2- methylthio) ethoxy] 26, 28-bis [3-pyridyl methyloxy] calix(4)arene, L2, are structurally (1H NMR and X-ray crystallography) and thermodynamically (solubility, Gibbs energy, enthalpy and entropy) characterised. The complexing ability of these ligands for metal cations is investigated using a variety of techniques. Solubility measurements and derived standard transfer Gibbs energies of these isomers indicate ...
Fingerprint Dive into the research topics of Phenylene-bridged core-modified planar aromatic octaphyrin: Aromaticity, photophysical and anion receptor properties. Together they form a unique fingerprint. ...
Demonstrated herein is a single rapid approach employed for synthesis of Ag-graphene nanocomposites, with excellent antibacterial properties and low cytotoxicity, by utilizing a continuous hydrothermal flow synthesis (CHFS) process in combination with p-hexasulfonic acid calix[6]arene (SCX6) as an effective particle stabilizer. The nanocomposites showed high activity against E. coli (Gram-negative) and S. aureus (Gram-positive) bacteria. The materials were characterized using a range of techniques including transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), Raman spectroscopy, UV-vis spectrophotometry, FT-IR, and X-ray powder diffraction (XRD). This rapid, single step synthetic approach not only provides a facile means of enabling and controlling graphene reduction (under alkaline conditions) but also offers an optimal route for homogeneously producing and depositing highly crystalline Ag nanostructures into reduced graphene oxide substrate.. ...
In this work the applicability of calix[6]arene columns for actinides analysis in urine samples and drinking water was investigated. A radiochemical procedure has been developed for U, Pu, Am analysis in urine. A simple and effective method has also been proposed on a specific column named AQUALIX, for the separation and preconcentration of U from drinking water. These procedures are suitable for routine analysis and require a considerably reduced number of steps of sample treatment as compared to current procedures ...
In supramolecular chemistry, host-guest chemistry describes complexes that are composed of two or more molecules or ions that are held together in unique structural relationships by forces other than those of full covalent bonds. Host-guest chemistry encompasses the idea of molecular recognition and interactions through noncovalent bonding. Noncovalent bonding is critical in maintaining the 3D structure of large molecules, such as proteins and is involved in many biological processes in which large molecules bind specifically but transiently to one another. There are four commonly mentioned types of non-covalent interactions: hydrogen bonds, ionic bonds, van der Waals forces, and hydrophobic interactions. Common host molecules are cyclodextrins, calixarenes, pillararenes, cucurbiturils, porphyrins, metallacrowns, crown ethers, zeolites, cyclotriveratrylenes, cryptophanes, carcerands, and foldamers. Host-guest chemistry is observed in inclusion compounds, Intercalation compounds, clathrates, and ...
Functionalizing the upper rim of resorcinarene-based cavitands allows a variety of compounds to be synthesized from a single scaffold. Using the upper-rim moieties as ligands for a variety of transition metal ions further increases the versatility of this class of host compounds. A new resorcinarene-based molecule functionalized with four pyridine and acetic acid ligands has been successfully prepared to explore the properties of metal-assembled complexes. To synthesize this compound, tetra(bromomethyl)cavitand was reacted with N-(2-pyridylmethyl)-N-ethylacetate amine to give ethyl acetate pyridine resorcinarene. Hydrolysis of the ester gave acetic acid pyridine resorcinarene (APRes) in good yield. Complexes with Cu2+, Co2+, and Zn2+ are currently being investigated and characterized by MS and 1H and 13C NMR.
We are interested in all aspects of coordination, organometallic and metallo-supramolecular chemistry with a particular emphasis upon the synthesis of cavity-shaped ligands and their use in organometallic catalysis and green chemistry. Much of our work relies on macrocyclic molecules, such as calixarenes, resorcinarenes, and cyclodextrins. The latter may be used as receptors or serve as platforms for the construction of multifunctional podands.. ...
This invention describes a new concept of flexible template-directed microporous partially pyrolyzed polymeric membranes which have greatly improved performance in separation of gas pairs compared to their precursor polymeric membranes. Organic hosts, such as crown ethers, cyclodextrins (CDs), calixarenes (CXs), and spherands, or polymeric additives, such as poly(ethylene glycol) (PEG) and polyvinylpyrrolidone (PVP) were used as the micropore-forming templates. Micropore-forming template/polymer blend membranes comprising organic micropore-forming templates embedded in a polymer matrix were prepared by dissolving the organic micropore-forming templates in the polymer solution followed by solution-casting and solvent evaporation or solvent exchange. Low-temperature selectively pyrolyzing micropore-forming templates in the micropore-forming template/polymer blend membranes at a nitrogen flow resulted in the formation of flexible microporous partially pyrolyzed polymeric membranes.
Importantly, many of the techniques we use to characterize these materials are frequently used throughout organic chemistry and include NMR, UV-Vis spectroscopy, cyclic voltammetry, and IR spectroscopy. These are all excellent techniques students may add to their organic chemistry resume, which will help prepare them for a multitude of potential career paths Advanced Time-Correlated Single Photon Counting Techniques (Springer Series in Chemical Physics) http://detroitpaintandglass.com/?lib/advanced-time-correlated-single-photon-counting-techniques-springer-series-in-chemical-physics. Martin na Muri (Croatia) during September 3-7, 2016 ref.: Calixarenes 2001 read pdf eatdrinkitaly.org. More information on these and other projects can be found on Prof. A complete publication list is available from Professor Herberts research web page. Some representative publications from the last few years are listed here. Low-scaling quantum chemistry approach to excited-state properties via an ab initio ...
All four hydrogens can be moved in a single step, one might move two at a time in two steps, or one might move one at a time in four steps. These processes would involve respectively 8, 6 or 4 electrons in each step. There is a fundamental difference between the first pathway and the last two; the latter involve ionic intermediates (zwitterions) whereas the first is neutral. As such one might imagine the process would depend on the ability of the solvent to stabilize any such zwitterion.. Let us start with a gas phase model (ωB97XD/6-311G(d,p)), and a transition state with one negative force constant is indeed found with C4v symmetry. The free energy barrier ΔG† for the process is 14.0 kcal/mol, which means the reaction will occur rapidly, even at lower temperatures of ~200K. A pack size of 8 seems preferred for this model. This is hardly a surprise since the formation of ionic intermediates would not be expected. One might however speculate thus. In the schematic above, n=1 and one might be ...
GFB-204 is a calixarene derivative that is a potent and selective inhibitor of VEGFR and PDGFR tyrosine phosphorylation. G FB-204 had been shown through several in-vivo and in-vitro studies to bind to VEGF and PDGF, block binding of VEGF and PDGF to their receptors and subsequently inhibit Flk-1 and PDGFR tyrosine phosphorylation and stimulation of the protein kinases Erk1, Erk2, and AKT and the signal transducer and activator of transcription STAT3. Since tumor angiogenesis depends on VEGF for initiation and PDGF for maintenance of blood vessels, an agent which suppresses the functions of both VEGF and PDGF would potentially be more effective in tumor control that an agent which targets only one of these two growth factors. Preclinical studies have also shown that GFB-204 inhibits capillary network formation in a dose-response manner and inhibits VEGF-dependent human brain endothelial cell migration. A lung xenograft study in mice has shown that GFB-204 is active in a dose dependent manner.
Calixarene-Based Molecules for Cation Recognition. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
Anion complexation studies on a series of platinum( II) tetrakis( pyrrolylpyridine) salts demonstrate the importance of CH-anion hydrogen bonds in coordinating anionic guests in solution and the solid-state.. Full text not available from this repository.. ...
The thesis deals with an investigation on calix[4] based receptors, namely calix[4]pyrrole and calix[4]arene derivatives and their use in different environmental and medical applications. The work conducted throughout this study addresses three main topics. i) The first topic discusses the ability of meso-octamethylcalix[4]pyrrole, CP to remove arsenite and arsenate anions from natural waters. Sites and nature of interaction of the receptor with the investigated anions using 1H NMR and molecular simulation studies are identified. Optimal environmental conditions led to maximal uptake of the investigated anions by CP, uptake capacity of the receptor and the kinetics of the process for the investigated anions are determined. CP was used to remove arsenic species from real water samples and its efficiency is demonstrated. ii) The second topic is related to the synthesis and structural characterisation of two thioacetamide calix[4]pyrrole derivatives namely, ...
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This doctoral thesis deals with the synthesis and binding studies of novel receptors based on aryl-extended calix[4]pyrrole scaffolds. Specifically, we describe a new synthetic methodology for the synthesis of water-soluble aryl-extended calix[4]pyrrole functionalized with water solubilizing groups distal to the binding site. This strategy avoids possible perturbation during the complex formation and permits the future construction of more elaborated receptors. We report the binding studies of these new water-soluble receptors with a series of pyridine N-oxides derivatives in water. The results obtained highlighted the ability of the aromatic cavity to protect and ensure the formation of hydrogen-bonding interactions in water. We also describe the synthesis of a new monophosphonate receptor for the selective recognition of neutral creatinine and creatininium cation in organic solution. Our studies demonstrate that the new monophosphonate receptor is able to form complexes with creatinine and ...
Two new types of methylcalix[4]resorcinarene-bonded stationary phases, (3-(C-methylcalix[4]resorcinarene)-2-hydroxypropoxy)-propylsilyl-appended silica particles (MCR-HPS) and bromoacetate-substituted MCR-HPS particles (BAMCR-HPS), have been synthesized and used as chiral stationary phases for high-performance liquid chromatography (HPLC) for the first time. The synthetic stationary phases are characterized by means of elemental analysis and Fourier-transform infrared spectroscopy. The chromatographic behavior of MCR-HPS and BAMCR-HPS was studied with several disubstituted benzenes and some chiral drug compounds under both normal phase and reversed-phase conditions. The results show that MCR-HPS has excellent selectivity for the separation of aromatic positional isomers and BAMCR-HPS exhibits excellent performance for separation of enantiomers of chiral compounds. © 2011 Wiley Periodicals, Inc ...
We introduce bis-aryl croconamides as a new member in the family of dual hydrogen bonding anion receptors. In this study a series of croconamides are synthesised, and the selectivity for anion binding is investigated (Cl− | Br− | I− in CH2Cl2). The croconamides exhibit different structures in the crystal pha
Bismuth(III) was quantitatively extracted from 0.1 M HCl with 1×10-4M of hexaacetato calix(6)arene in toluene. It was stripped with 2 M nitric acid and determined from the aqueous phase spectrophotometrically at 470 nm as its complex with thiourea. The various parameters such as pH, reagent concentration, kind of diluents, stripping agents, effect of diverse ions were studied to ascertain optimum conditions for the quantitative extraction of bismuth . Bismuth was separated from thorium(IV), iron(III), manganese(II), chromium(III). lead(II), palladium(II) and thallium(III) in multicomponent mixtures. The method was extended for the analysis of bismuth in real samples ...
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Formation of Amines (RNH2) and the Cyanide Anion (CN-) in Electron-Irradiated Ammonia-Hydrocarbon Interstellar Model Ices. The present laboratory study simulated cosmic-ray-induced grain chemistry of nitrogen-bearing organic molecules in interstellar and cometary ices. Model ices of ammonia (NH3)-methane (CH4) were prepared and irradiated at 10 K under contamination-free, ultrahigh vacuum conditions with energetic electrons generated in the track of galactic cosmic-ray particles. The radiolysis-induced processing of nitrogen-bearing molecules was then monitored on line and in situ by a Fourier transform infrared spectrometer and a quadrupole mass spectrometer during the irradiation phase and subsequent warm-up phases. The analogous processing was also achieved in ammonia (NH3) and six hydrocarbon (CnH2n+2; n=1-6) ices. The formation of cyanide anion (CN−) was commonly observed in both ices at 10 K, the temporal column density fit of which traced back the involvement of methylamine ...
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Luis Martínez-Crespo, Jia Liang Sun-Wang, Andres Felipe Sierra, Gemma Aragay, Ekaitz Errasti-Murugarren, Paola Bartoccioni, Manuel Palacín, P. ...
Understanding molecular recognition is central to many chemical processes such as in the development of drugs, receptors, sensors, catalysts and supramolecular materials. Over the years we have been particularly interested in designing molecular receptors for the purpose of separating, sensing, synthesizing or hydrolyzing biologically important compounds. Some of our current interests include (a) cation and anion recognition, (b) chiral receptors and catalysts for stereoselective separation and synthesis of biological compounds like amino acids and other chemical intermediates, (c) stereoselective synthesis of 1,2-diamines, (d) DNA base recognition with metal complexes and (e) mono and multinuclear metal complexes for catalyzing the hydrolysis and synthesis of nucleic acids and proteins. While some of our projects may at first appear unrelated, understanding one is useful for understanding others. For example, understanding anion recognition is not only useful for sensing fluoride but also for ...
Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact [email protected] ...
Arctic Monkeys are pleased to announce they will be performing at Arenes De Vienne, in Vienne, France on Monday 22nd July 2013. Tickets will go on sale at 10am(CET) on Wednesday 6th February from here. ...
Instructions for Making a Nut Sheller From the Full Belly Project The stator is the concrete piece that makes up the outside of the machine and does not turn. Stator Mold Set 1. Outer Stator Mold 2. Smooth the inside edges by scraping the upper rim with a flat metal object. 16 ...
Stable π-dimers are formed upon oxidation of the model units of proposed calix[4]arene-based molecular actuators in a solvent of low dielectric constant ...
TTYH1, 0.1 mg. TTYH1 is a member of the tweety family of proteins, a family of chloride anion channels containing five transmembrane regions.
The first stage of the FE storage ‑ the containment of Kazan.. After army-look continued to penetrate the Russian army on Kazan. When men strong Vorhut had overcome the 7000 on 22 August the Bulak, had approached the mountain erklommen and the fortress wall, it was attacked by a strong act arene department, which undertook a loss, surprisingly. (The sources report that the numerical strength amounted to act arene of 5000 riders and 10,000 men foot people.) The Vorhut was split into two parts. You hurried however the Strelitzen to assistance and reduced the attack act arene. Whereupon the Vorhut turned into to the counter attack and drove the enemy up to the town-gates back. At the same time the fortress cannons opened the fire; it remained however without effect.. In the evening 23 of August the Russian troops included the city and „intercepted from all sides and entrances to the city; nobody of them could come the city abandoned still into the city .. The advance guard and the majority ...
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AROMATICS, also known as arenes, is any of a large class of unsaturated chemical compounds characterized by one or more planar rings of atoms joined by covalent bonds of two different kinds ...
When you throw a party, you hope your guests will have a good time. However, a DUI charge can quickly ruin the night and impact the lives of your guests for years to come.
Map and directions to Cinematic Guest House in Germiston / Located at -26.190224,28.153948, Cinematic Guest House is situated in Germiston. Find its ...
In XSA-133, which is the Xen Security Advisory that provides details related to this vulnerability, it states that Systems running only x86 PV guests are not vulnerable. This vulnerability applies to QEMU guests on KVM and XEN HVM Guests. Linode only uses XEN PV guests which are not affected by this vulnerability. Specifically, XEN PV guests do not require the use of QEMU.. ...
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Please welcome the second of my guests, K.M. Herkes, to talk about the world in her Rough Passages stories. :) ~*~ I read the instructions as,
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The Insider Exclusive. The views and opinions of the guests do not necessarily reflect the views or opinions of the Insider Exclusive TV show and its staff.. ©2021 PRI Inc - All rights reserved. , Site Was Produced By Fsquaredmedia. ...
ARhiSi combined analysis of ARhiSi-1 and ARhiSi-2: responder (healed or improved) to treatment from visit 2 (day 3) to visit 5 (day 14) (FAS, full analysis set;
The 4-amino-1,8-naphthalimide-based anion receptor 3 binds dihydrogenphosphate with 1:1 stoichiometry through cooperative hydrogen bonding to a naphthalimide N-H and thiourea N-H groups. This was clearly established from 1H NMR titration experiments in DMSO-d6 where a substantial shift in the resonance for the naphthalimide N-H was observed concomitant with the expected thiourea N-H chemical shift migration upon successive additions of H2PO4−. However, whilst 1H NMR titration experiments indicate that 3 was capable of binding other anions such as acetate, the naphthalimide N-H does not participate and the N-H resonance was essentially invariant during the titration. The lack of cooperative binding in this instance was justifiable on steric grounds ...
A modified calix[4]pyrrole, namely meso-tetramethyl-tetrakis-(4-hydroxyphenyl) calix[4]pyrrole, 1, has been synthesized and characterized. (1)H NMR investigations in various deuterated solvents seems to indicate that this receptor interacts with acetone-d(6). The solution thermodynamics of 1 in various solvents is reported. Complexation studies in CD(3)CN show that the NH and OH functionalities of 1 are the active sites of its interaction with the fluoride and the dihydrogen phosphate anions. The composition of the anion complexes was established through conductance measurements. In all cases, 1:1 complexes are formed. The thermodynamics of anion complexation in acetonitrile and N,N-dimethylformamide is discussed comparatively with previous reported data for the parent calix[4]pyrrole, 2, and these anions in these solvents. The medium effect on anion complexation is discussed in terms of the solvation properties of the reactants and the product in acetonitrile and N,N-dimethylformamide. An oligomeric
0053] A solvent useful in the present invention is a non-aqueous, aprotic, polar organic substance which dissolves the solute. Blends of more than one solvent may be used. Generally, solvents may be carbonates, carboxylates, lactones, phosphates, five or six member heterocyclic ring compounds, and organic compounds having at least one C1-C4 group connected through an oxygen atom to a carbon. Lactones may be methylated, ethylated and/or propylated. Generally, the electrolytic solution comprises at least one solute dissolved in at least one solvent. Useful solvents that can be made for the present invention include ethylene carbonate (EC), propylene carbonate (PC), butylene carbonate (BC), dimethyl carbonate (DMC), diethyl carbonate (DEC), dipropyl carbonate (DPC), dibutyl carbonate (DBC), ethyl methyl carbonate (EMC), methyl propyl carbonate (MPC), ethyl propyl carbonate (EPC), tetrahydrofuran, 2methyl tetrahydrofuran, 1,3-dioxolane, 1,4-dioxane, 1,2-dimethoxyethane, 1,2-diethoxyethane, ...
Heterocyclic N-oxides have emerged as promising therapeutic drugs or prodrugs thanks to their, inter alia, antimicrobial, antitumoral, anti-inflammatory and antiviral activities.1 In this context, efforts have been made to synthesise derivatives of quinoxaline 1,4-di-N-oxides and phenazine N,N′-dioxides and study their biological activities.2,3 Notably, pyrazine N,N′-dioxide (PZDO) is the redox-active motif embedded in these two types of heterocyclic N-oxides and is thought to account for the antitumoral activities towards hypoxic cells. Creating artificial receptors for PZDO and its analogues might inform the development of improved supramolecular drug delivery systems and sensors for this class of biologically active species.4,5 As a first step towards realising this promise, we report here a series of calix[4]pyrrole-based receptors that allow for the molecular recognition of PZDO in CD3CN/CD3OD solution and in the solid state. Calix[4]pyrroles (C4Ps) are a class of easy-to-prepare ...
Read online: http://dx.doi.org/10.1002/anie.201403576. Khan, L.U., Brito, H.F., Hölsä, J., Pirota, K.R., Muraca, D., Felinto, M.C.F.C., Teotonio, E.E.S., and Malta, O.L., Red-Green Emitting and Superparamagnetic Nanomarkers Containing Fe3O4 Functionalized with Calixarene and Rare Earth Complexes, Inorg. Chem. 53 (2014) 12902-12910 ...
Three calix[4]arene (Cal-4) derivatives which separately contain ethylester (1), carboxylic acid (2), and crownether (3) at the lower rim with a common reactive thiol at the upper rim were synthesized and constructed to self-assembled monolayers (SAMs) on Au films. After spectroscopic characterization of the monolayers, surface coverage and orientation of antibody immobilized on the Cal-4 derivative SAMs were studied by surface plasmon resonance (SPR) technique. Experimental results revealed that the antibody could be immobilized on the Cal-4 derivatives spontaneously. The orientation of absorbed antibody on the Cal-4 derivative SAMs is related to the SAMs dipole moment. The possible orientations of the antibody immobilized on the Cal-4 derivative 1 SAM are lying-on or side-on, while on the Cal-4 derivative 2 and Cal-4 derivative 3 head-on and end-on respectively. These experimental results demonstrate the surface dipole moment of Cal-4 derivative appears to be an important factor to antibody
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Close The Infona portal uses cookies, i.e. strings of text saved by a browser on the users device. The portal can access those files and use them to remember the users data, such as their chosen settings (screen view, interface language, etc.), or their login data. By using the Infona portal the user accepts automatic saving and using this information for portal operation purposes. More information on the subject can be found in the Privacy Policy and Terms of Service. By closing this window the user confirms that they have read the information on cookie usage, and they accept the privacy policy and the way cookies are used by the portal. You can change the cookie settings in your browser. ...
A family of heterocyclic thiosemicarbazone dyes (3a-f and 4) containing furyl groups was synthesized in good yields, characterized and their response in acetonitrile in the presence of selected anions was studied. Acetonitrile solutions of 3a-f and 4 showed absorption bands in the 335-396 nm range which are modulated by the electron donor or acceptor strength of the heterocyclic systems appended to the thiosemicarbazone moiety. Fluoride, chloride, bromide, iodide, dihydrogen phosphate, hydrogen sulphate, nitrate, acetate and cyanide anions were used in recognition studies. From these anions, only sensing features were seen for fluoride, cyanide, acetate and dihydrogen phosphate. Two clearly different chromo-fluorogenic behaviours were observed: (i) a small shift of the absorption band due to the coordination of the anions with the thiourea protons and (ii) the appearance of a new red shifted band due to deprotonation. For the latter effect, a change in the colour of solution from pale yellow to ...
Two new near-infrared chemodosimeters for cyanide anion based on 5,10-dihexyl-5,10-dihydrophenazine were designed and synthesized. With dicyano-vinyl groups as the recognition site and electron-withdrawing groups on both sides, probe 1 exhibited an intramolecular charge transfer (ICT) absorption band at 545 nm and emission band at 730 nm, respectively, and thus showed an ICT block process and realized an on-off response after bilateral reaction with cyanide anions in CH3CN. Probe 2 utilized an unreactive formyl group instead of one of the two reactive dicyano-vinyl groups as the electron-withdrawing component. Due to the unilateral recognition process the ICT of probe 2 was redirected and lead to a remarkably colorimetric and ratiometric near-infrared (NIR) fluorescent response for cyanine. Both probes provided high sensitivity and selectivity with apparent response signals which can be observed by naked eyes, even in the copresence of various other interference anions. Optical spectroscopic ...
The binding properties of bis(imidazolium) hosts 1a-c derived from amino acids towards different anions have been studied by 1H NMR titration experiments in 95 : 05 CD3CN : H2O at 303 K, ESI-MS and theoretical calculations. Among this family, the salt 1c showed a strong and high selectivity for chloride anions. Transmembrane chloride transport activity has also been studied for the three bis(imidazolium) based transporters in POPC liposome models, and compound 1a was identified as an active chloride/nitrate exchanger ...
The binding properties of bis(imidazolium) hosts 1a-c derived from amino acids towards different anions have been studied by 1H NMR titration experiments in 95 : 05 CD3CN : H2O at 303 K, ESI-MS and theoretical calculations. Among this family, the salt 1c showed a strong and high selectivity for chloride anions. Transmembrane chloride transport activity has also been studied for the three bis(imidazolium) based transporters in POPC liposome models, and compound 1a was identified as an active chloride/nitrate exchanger ...
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Close The Infona portal uses cookies, i.e. strings of text saved by a browser on the users device. The portal can access those files and use them to remember the users data, such as their chosen settings (screen view, interface language, etc.), or their login data. By using the Infona portal the user accepts automatic saving and using this information for portal operation purposes. More information on the subject can be found in the Privacy Policy and Terms of Service. By closing this window the user confirms that they have read the information on cookie usage, and they accept the privacy policy and the way cookies are used by the portal. You can change the cookie settings in your browser. ...
The metal cation is the guest and the organic structure is the host in (a) 18-crown-6 complex of potassium cation (K+) and (b) sodium (Na+) complexed by a calix[4]arene ...
Blas, JR, Lopez-Bes JM, Marquez M, Sessler JL, Luque FJ, Orozco M. 2007. Exploring the dynamics of calix[4]pyrrole: effect of solvent and fluorine substitution. Chemistry (Weinheim an der Bergstrasse, Germany). 13(4):1108-1116. Abstract ...
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A device for collecting, testing and transporting a liquid specimen of urine or the like incorporates a cup or container and a cooperating lid which becomes sealed about its upper rim when the lid is mated with the specimen-containing cup. An upwardly open subchamber of defined volume, formed in the bottom wall of the cup, is sealed by engagement with a downwardly extending hollow plug portion of the lid that has a bottom wall containing a central aperture closed by a frangible sheet material seal. When initial testing is to be conducted, an elongated assay cartridge is inserted vertically downward through the hollow plug. The bottom end splits open the frangible seal and enters into the subchamber containing the defined volume of the liquid sample, which becomes totally absorbed by a pair of elongated nitrocellulose strips, along which the liquid moves by capillary action to effect the assay tests.
An injection blow-molded disposable tumbler is formed from a polymeric material and includes a fortified upper rim having a thickness greater than the adjacent sidewall. The tumbler may be formed of a variety of resinous materials and exhibits improved toughness and crush resistance as well as aesthetic qualities particulary desired by consumers.
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Duff, Thomas and Grüßing, André and Thomas, Jean-Luc and Duati, Marco and Vos, Johannes G. (2003) Luminescent anion recognition: Probing the interaction between dihydrogenphosphate anions and Ru(II) polypyridyl complexes in organic and aqueous media. Polyhedron, 22 (5). pp. 775-780. ISSN 0277-5387 ...
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Abstract] The ditopic receptor L3 [1-(2-((7-(4-(tert-butyl)benzyl)-1,4,7,10-tetraazacyclododecan-1-yl)methyl)phenyl)-3-(3-nitrophenyl)urea] containing a macrocyclic cyclen unit for Cu(II)-coordination and a urea moiety ...
I was tidying up a guest room today because previous guests have gone and new ones are arriving on Monday. I was thinking about how much I enjoy having guests...and about guest rooms in general, and what they shoud have in them. (Not a cat! Begone,
Page 1 of 2 - Guest suggestions - posted in Interviews: Please add suggestions for interview guests below, including a link to the guests bio or page and some questions youd like to see them asked. Previous guests include: Aaron DrakeAnne CorwinArthur De VanyAubrey de GreyBen GoertzelCalvin MercerChristine PetersonDavid GobelDidier CoeurnelleDr. Brian WowkEliezer YudkowskyEric SchulkeFelicia Nimue AckermanGary TaubesGeordie RoseGeordie RoseGeorge DvorskyHugo De GarisJacque FrescoJames...
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On Mon, 03 Aug 2009 16:33:32 -0500 Mark Allums ,[email protected], wrote: , Chris wrote: , , On Monday 03 August 2009, [email protected] wrote: , ,, Chris wrote: , ,,, I am trying to get Screen resize and Seamless mode working on , ,,, Lenny guest systems to no avail. , ,,, , ,,, I have tried insalling the guest-utils packages, as well as the , ,,, guest-additions the manual way with m-a. They install fine, but , ,,, sreen-resize and seamless mode dont work. , ,,, , ,,, Does anyone have this working at all? Ive tried various , ,,, xorg.conf files with the video driver and no screen resolutions. , ,,, , ,,, I am running virtualbox-ose 2.1.4 from lenny-backports on the , ,,, host. , ,,, , ,,, Thanks, , ,,, , ,,, Chris , ,, I also have same problem. , ,, I have Debian Sid LXDE, Debian Sid XFCE and Debian Sid KDE as a , ,, guest. They were first Lenny and screen size was to big so I was , ,, edit xorg.conf and it was fine. After upgrade to Sid all of them , ,, have to small screen with black frame ...
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You are currently viewing our boards as a guest which gives you limited access to view most discussions and access our other features. By joining our free community you will have access to post topics, communicate privately with other members (PM), respond to polls, upload content and access many other special features. Registration is fast, simple and absolutely free so please, join our community today ...
I am so glad to see the list below. I think that they are all helpful to the AMBER community. Thank you. I look forward to utilize some more of the RESP charges and FF parameters in the list when they are available in REDDB in the near future ...
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Calixarenes resemble chalices (calix in Latin) with hydrophobic cavities that can hold smaller molecules or ions, an example of ... Calixarenes are the general category of macrocycle oligomers formed by hydroxyalkylation of a phenol and an aldehyde; ... Gutsche, C. D. (1989). Calixarenes. Cambridge: Royal Society of Chemistry. ISBN 085186385X. CS1 maint: discouraged parameter ( ...
The inherently chiral calixarenes featured an XXYZ or WXYZ substitution pattern, such that the planar representation of the ... The chirality in these calixarenes is instead derived from the curvature of the molecule in space. Due to the initial lack of a ... The term was first coined by Volker Boehmer in a 1994 review, to describe the chirality of calixarenes arising from their non- ... After creating a series of traditionally chiral calixarenes (through the addition of a chiral substituent group on the top or ...
... s are a type of calixarene. Other types of resorcinarenes include the related pyrogallolarenes and ...
It is observed in compounds such as calixarenes and acridines. Peri-substitution occurs in naphthalenes for substituents at the ...
Many synthetic ionophores are based on crown ethers, cryptands, and calixarenes. Pyrazole-pyridine and bis-pyrazole derivatives ...
The Department conducts research in the following fields: thio-phosphorylated derivatives of resorcinols and calixarenes; ... "Calixarene Chemistry", "Phosphorus-Containing Analogues of Natural Compounds", "Chemistry of Heterocyclic Compounds" and many ...
CB[10] is large enough to hold other molecular hosts such as a calixarene molecule. With a calixarene guest different chemical ... Allosteric control is provided when an adamantane molecule forces a cone conformation with a calixarene - adamantane inclusion ... calixarenes, and pillararenes. Cucurbiturils are amidals (less precisely aminals) and synthesized from urea 1 and a dialdehyde ...
Classically artificial enzymes bind substrates using receptors such as cyclodextrin, crown ethers, and calixarene. Artificial ...
They are structurally similar to the cucurbiturils and calixarenes that play an important part in host-guest chemistry. The ...
It selectively complexes cesium cations (Cs+), with an efficiency comparable to that of some calixarenes or crown ethers. It ...
... are a type of calixarene, and a subset of resorcinarenes that are substituted with a hydroxyl at the 2- ...
This is accomplished by dynamic covalent chemistry in a one-pot condensation of 6 equivalents of a tetraformyl calixarene and ... The first generation carcerands are based on calixarene hemicarcerands with 4 alkyl substituents on the upper rim and 4 ...
... s would be to the next decade what calixarenes have been to the previous one. 김, 하연 (28 August 2018). "포스텍 김기문 교수, 세계최초 쿠커비투릴 책 ...
The compound is related to calixarenes in terms of its host-guest properties and its synthesis CTV derivates are known to bind ...
supramolecular chemistry: calixarenes, rotaxanes, and catenanes. *dendrimer design. *carbohydrate clusters and carbohydrate ...
Electrophilic aromatic substitutions as the hydroxyl group is activating, for example synthesis of calixarenes [34] ...
Calixarenes bear a fascinating class of macrocycles that have served broadly in molecular recognition and supramolecular ... Calixarenes in lipase biocatalysis and cancer therapy. Bentham Science Publishers. Journal. Current Organic Chemistry. Keywords ... Calixarenes in lipase biocatalysis and cancer therapy This research article by Dr. Serdar Karakurt et al. is published in ... This ability of calixarenes to amplify, upon hosting different enzymes their catalytic capacity, can be fruitfully explored to ...
Calixarene Assisted Rapid Synthesis of Silver-Graphene Nanocomposites with Enhanced Antibacterial Activity.. ACS Applied ... Calixarene Assisted Rapid Synthesis of Silver-Graphene Nanocomposites with Enhanced Antibacterial Activity ...
It has been shown that both effectors (100 μM) affect PMCA enzymatic activity: calixarene C-90 inhibits it b … ... We investigated the influence of calixarene C-90 and IPT-35 on plasma membrane Ca2+- pumping АТРase (PMCA), intracellular ... Calixarene C-90 can be used in obstetric cases for the simultaneous use of oxytocin for enhancing uterine contractions, and IPT ... It has been shown that both effectors (100 μM) affect PMCA enzymatic activity: calixarene C-90 inhibits it by 75% and IPT-35 ...
Calixarene-Based Molecules for Cation Recognition. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y ... Keywords: Macrocycles; Cyclophanes; Calixarenes; Ion Recognition Macrocycles; Cyclophanes; Calixarenes; Ion Recognition Autor: ... Calixarene-Based Molecules for Cation Recognition - Descarga este documento en PDF. Documentación en PDF para descargar gratis ... Abstract This review discusses molecular design principles of calixarene-type macrocycles for ion recognition and gives ...
A calixarene derivative mediates rapid detoxification of the deadly poison VX. On 13th February 2017, the half-brother of the ... The calixarene moreover selectively cleaves the P-S bond of VX and complete detoxification requires at least one equivalent, ... With a half-life of under 4 min, the calixarene promotes VX detoxification by a factor of 3500 over the rate of spontaneous ... On the other hand, the action of the calixarene on soman, which lacks the positively charged side chain, is much less ...
Such a calixarene was at the heart of a recent story where an attempt was made to induce it to capture cyclobutadiene in its ... Do electrons prefer to move in packs of 4, 6 or 8 during proton exchange in a calixarene? is licensed by Henry Rzepa under a ... Tags: animation, calixarene, chiral, dielectric, free energy barrier, gas phase, gas phase model, pericyclic, proton transfer, ... At the base of the calixarene are four hydroxyl groups, arranged in either a left or right handed manner. The molecule, in ...
Development of a time-resolved immunoassay delay system based on lanthanide ions complexed by calixarene derivatives. Poster ... Development of a time-resolved immunoassay delay system based on lanthanide ions complexed by calixarene derivatives. / ... Development of a time-resolved immunoassay delay system based on lanthanide ions complexed by calixarene derivatives. 1994. ... title = "Development of a time-resolved immunoassay delay system based on lanthanide ions complexed by calixarene derivatives", ...
Calixarene-based receptors for molecular recognition Authors: MUSTAFA YILMAZ, SERKAN ERDEMİR Abstract: Calixarene-based ... This work briefly reviews the recent development of calixarenes. Keywords: Calixarene, receptor, host-guest, drugs, chiral, ... Due to their bowl-shaped geometry, calixarene macrocycles are used as hosts allowing organic and inorganic guests to coordinate ...
Organic hosts, such as crown ethers, cyclodextrins (CDs), calixarenes (CXs), and spherands, or polymeric additives, such as ... Organic hosts, such as crown ethers, cyclodextrins (CDs), calixarenes (CXs), and spherands, or polymeric additives, such as ... Organic hosts, such as crown ethers, cyclodextrins (CDs), calixarenes (CXs), and spherands, or polymeric additives, such as ... Organic hosts, such as crown ethers, cyclodextrins (CDs), calixarenes (CXs), and spherands, or polymeric additives, such as ...
Electrochemical impedance spectroscopy (EIS) is used to study the response of the calixarenes membrane in contact with aqueous ... calixarenes have already found applications in the design of chemical sensors based on using an electrochemical transduction. ... Abstract : Due to their recognition properties and efficiency for the detection of toxic metals, calixarenes have already found ... Electrochemical impedance spectroscopy (EIS) is used to study the response of the calixarenes membrane in contact with aqueous ...
Martin na Muri (Croatia) during September 3-7, 2016 ref.: Calixarenes 2001 read pdf eatdrinkitaly.org. More information on ...
Much of our work relies on macrocyclic molecules, such as calixarenes, resorcinarenes, and cyclodextrins. The latter may be ...
GFB-204 is a calixarene derivative that is a potent and selective inhibitor of VEGFR and PDGFR tyrosine phosphorylation. G FB- ... Description: GFB-204 is a calixarene derivative that is a potent and selective inhibitor of VEGFR and PDGFR tyrosine ...
Through adequate decoration of the small rim of the calixarenes, functional molecules can then be introduced on the immobilized ... One cool experiment is determination of surface coverage by functionalizing the electrode with COOH terminated calixarenes and ... calixarene subunits, paving the way for an accurate spatial control of the chemical composition of a surface at molecular level ...
... Katarzyna Kiegiel, Lukasz Steczek, and Grazyna ... Katarzyna Kiegiel, Lukasz Steczek, and Grazyna Zakrzewska-Trznadel, "Application of Calixarenes as Macrocyclic Ligands for ...
The NMR and X-ray data were in close agreement and suggested the calixarene explores the protein surface by binding to three or ... Despite calixarenes potential for this job, researchers lacked details about how the molecules interact with protein surfaces ... A calixarene (stick) binds to the surface of the cytochrome c protein (space fill). ... A calixarene (stick) binds to the surface of the cytochrome c protein (space fill). ...
calixarene: Any of a class of organic macrocycle containing a ring of phenol groups linked by a short bridge; they mimic some ...
Calixarenes and cations: a time-lapse photography of the big-bang. Alessandro Casnati. Chem. Commun., 2013, 49, 6827-6830. DOI ... Calixarenes and cations. Jack Harrowfield. Chem. Commun., 2013,49, 1578-1580. DOI: 10.1039/C3CC38667H ... including suggestions on other articles that were also felt to have played a seminal role in calixarene chemistry. As a result ... Jack Harrowfields Viewpoint focussing on the 1985 contribution of Tony McKerveys group to the field of calixarenes and ...
Calixarenes: A Versatile Class of Macrocyclic Compounds (Topics in Inclusion Science (Closed)) by Jacques Vicens (Edited ) ... Volker Bohmer (Edited )Buy . Books online: Calixarenes: A Versatile Class of Macrocyclic Compounds (Topics in Inclusion Science ... Bridged Calixarenes.- 8. Double Calixarenes and Future Directions.- References.- Two: X-Ray Structural Data on Calixarene ... Calixarene-Based Cation Receptors and Carriers.- 1. Introduction.- 2. Calixarene Podands with Ether Chains.- 3. Calixarene ...
Calixarene alpha-ketoacetylenes: versatile platforms for reaction with hydrazine nucleophile A. A. Muravev, S. E. Solovieva, F ... Functionalisation is calixarene conformation and linker independent enabling access to a library of structures. ...
Calixarene surfactants are designed to structure the membrane domains of proteins through hydrophobic interactions and a ... Calixarene Surfactants. G-Biosciences offers specially formulated reagents (detergents/surfactants) to aid the extraction, ... Calixarene surfactants *These molecules are designed to structure the membrane domains of proteins through hydrophobic ... Calixarene surfactants are designed to structure the membrane domains of proteins through hydrophobic interactions and a ...
Copper complexes bearing an NHC-calixarene unit: synthesis and application in click chemistry B. Ourri, O. Tillement, T. Tu, E ... Copper complexes bearing an NHC-calixarene unit: synthesis and application in click chemistry ...
Archive for the calixarenes Category. Optical activity of a chiral calix[4]arene. Determination of absolute configuration ...
The possibility to ion-mill CoPt film using EB drawn calixarene resist pattern as a mask has been studied. We formed 30 nm ... The 39-to 106-nm-sized CoPt magnetic dot arrays were formed by30-keV-electron beam (EB) drawing with thin calixarene resist and ... T. Tamura et al., "Fabrication of Nanometer Sized Si Dot Arrays Using Ar Ion Milling with Calixarene Resist Dot Arrays", Key ... Fabrication of Nanometer Sized Si Dot Arrays Using Ar Ion Milling with Calixarene Resist Dot Arrays p.116 ...
"Experimental study of inhibition of corrosion of mild steel in 1M HCl solution by two newly synthesized calixarene derivatives ... Experimental study of inhibition of corrosion of mild steel in 1M HCl solution by two newly synthesized calixarene derivatives ... Inhibition of the corrosion of mild steel in molar hydrochloric acid by two calixarenes, including the effect of inhibitor ... Experimental study of inhibition of corrosion of mild steel in 1M HCl solution by two newly synthesized calixarene derivatives ...
Two different isomers of the calixarene were prepared in an analogous method to the tetra-alkylated calixarenes in Chapter Four ... Calixarene Linked Bis-Porphyrin Hosts for Fullerenes and the Assembly of Supramolecular Ferrocene-Porphyrin-Fullerene Triads. ... Calixarene Linked Bis-Porphyrin Hosts for Fullerenes and the Assembly of Supramolecular Ferrocene-Porphyrin-Fullerene Triads. ... These porphyrins have also been coupled to calixarenes to form bis-porphyrins, however these host displayed no affinity for ...
... two kinds of deep-cavity calixarene powder materials, p-[1-(4-methoxyphenyl)-1-methyl-ethyl] calyx[8]arene (I) and p-[1-(4- ... Cigarette samples were prepared by respectively adding calixarene materials I and II into filter tip at the rate of 10 mg/cig ... Development of deep-cavity calixarene materials for selectively reducing benzo[a]pyrene and major phenolic compounds in ... Development of deep-cavity calixarene materials for selectively reducing benzo[a]pyrene and major phenolic compounds in ...
The detailed data analysis of an NMR titration of 15N-labelled cytochrome c with the calixarene revealed the presence of two or ... Solved the first crystal structure of a protein-calixarene complex (at 1.4 Angstrom resolution). The results provide exact ... the calixarene generates a tetrameric protein assembly and exhibits a preference for arginine. The structure of the modified ... the crystal structures of the calixarene complexed to lysozyme in its native form and in a modified form were solved to 1.7 ...
... DSpace/Manakin Repository. ... While only the thiodigalactoside part of the hybrids showed strong binding, the calixarene part was responsible for observed ... an antagonist calixarene-based therapeutic agent. NMR spectroscopy was used to evaluate the interactions of these compounds ... cellular experiments were conducted to compare the cytotoxic effects of the hybrids with those of a calixarene derivative. ...
Resorcinarenes are a type of calixarene. Other types of resorcinarenes include the related pyrogallolarenes and ...
Calixarenes for Separations , The calixarenes, from their aborted birth in the s and their successful but almost . ... Calixarenes for Separations (ACS Symposium Series). First glimpse at a calixarene clathrate. Jonathan W. This article is part ... Calixarenes for Separations (ACS Symposium Series). *Calixarenes for Separations by Gregg J. Lumetta, Robin D. Rogers, ... Happy reading Calixarenes for Separations Bookeveryone. Download file Free Book PDF Calixarenes for Separations at Complete PDF ...
Calixarene complexes of anion-bridged oligouranyl species DeLaigue, X.; Gutsche, C.; Harrowfield, J.; Ogden, Mark; Skelton, B. ... The calixarenes are synthetically versatile and well established cluster-supporting ligands, which to date have not been ... Amino acid functionalised calixarenes: crystal growth modifiers and low molecular weight gelators ... Acidic amino acid functionalised calixarenes were investigated as crystal growth modifiers. The self-assembly behaviour of ...
Non-covalent calixarene-amino acid complexes formed by MALDI-MS. / Stone, Michele M.; Franz, Andreas H.; Lebrilla, Carlito B. ... Non-covalent calixarene-amino acid complexes formed by MALDI-MS. In: Journal of the American Society for Mass Spectrometry. ... Stone, M. M., Franz, A. H., & Lebrilla, C. B. (2002). Non-covalent calixarene-amino acid complexes formed by MALDI-MS. Journal ... Non-covalent calixarene-amino acid complexes formed by MALDI-MS. Journal of the American Society for Mass Spectrometry. 2002 ...
Extraction of hemoglobin with calixarenes and biocatalysis in organic media of the complex with pseudoactivity of peroxidase. ...
Classically artificial enzymes bind substrates using receptors such as cyclodextrin, crown ethers, and calixarene. Artificial ...
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003... Explanation of calixarene ... Find out information about calixarene. A cyclic structure containing the group n , where Ar represents an aryl group. ... calixarene. Also found in: Wikipedia. calixarene. [kə′lik·sə‚rēn] (organic chemistry) A cyclic structure containing the group ... Calixarene , Article about calixarene by The Free Dictionary https://encyclopedia2.thefreedictionary.com/calixarene ...
Calixarenes as hosts in aqueous media: Inclusion complexation of ferrocene derivatives by a water-soluble calix[6]arene. ... Zhang, L., MacÍas, A., Lu, T., Gordon, J. I., Gokel, G. W., & Kaifer, A. E. (1993). Calixarenes as hosts in aqueous media: ... Calixarenes as hosts in aqueous media : Inclusion complexation of ferrocene derivatives by a water-soluble calix[6]arene. / ... T1 - Calixarenes as hosts in aqueous media. T2 - Inclusion complexation of ferrocene derivatives by a water-soluble calix[6] ...
Amino acid functionalised calixarenes: crystal growth modifiers and low molecular weight gelators. 191761_Goh2013.pdf (18.27Mb) ... Calixarenes can be used as well-defined scaffolds for investigating structure-activity relationships of additives and their ... The calixarene-electrolyte hydrogels had a fibrous appearance, as characterised by atomic force microscopy. Some hydrogels ... A racemic mixture of the proline calixarenes gave a less stable hydrogel compared with hydrogels of the enantiopure compounds. ...
Thermosensitive polymers are a class of "smart" materials that have the ability to respond to a change in temperature. SPECIFIC POLYMERS synthesize a broad array of monomers and polymers of interest in this area ...
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  • Calixarenes bear a fascinating class of macrocycles that have served broadly in molecular recognition and supramolecular chemistry. (eurekalert.org)
  • Calixarenes can also facilitate and decrease the time required for the synthesis of complex molecules. (eurekalert.org)
  • This paper provides an overview of the utilization of calixarenes in biocatalysis and cancer therapy and diagnosis. (eurekalert.org)
  • The reported examples highlighted in this work illuminate the applicability of calixarenes to advance the field of biocatalysis and cancer therapeutics and diagnostics. (eurekalert.org)
  • Calixarenes have also obliged as drug delivery machineries that are responsive to the tumor microenvironment and a selective release of the drug to cancer cells has been achieved. (eurekalert.org)
  • Due to the ability of calixarenes to be tailored with different functional groups they can accommodate different cytotoxic agents and thus can serve as drug delivery vehicles. (eurekalert.org)
  • It was also shown that calixarene C-90 in vitro can increase velocity of oxytocin-initiated contractions, whereas IPT-35 can suppress this aforementioned parameter. (nih.gov)
  • Three: Inclusion Properties of Calixarenes and Their Derivatives. (fishpond.co.nz)
  • The rich class of structurally well-defined calixarenes have been studied for several decades and some of their water-soluble derivatives are well known for their complexation ability of various proteins. (nuigalway.ie)
  • Derivatives of calix[n]arenes could be formed by inserting binding groups such as amines and/or alcohols into the upper and lower rim positions of the calixarene moiety [15]. (thefreedictionary.com)
  • 2006), calixarene derivatives (SAHIN et al. (thefreedictionary.com)
  • Deska M, Dondela B, Sliwa W (2015) Selected applications of calixarene derivatives. (springer.com)
  • Calixarenes can also facilitate and decrease the time required for the synthesis of complex molecules. (eurekalert.org)
  • One: History and Synthesis of Calixarenes. (fishpond.co.nz)
  • Single Step Synthesis and Properties of Calixarenes. (fishpond.co.nz)
  • 3. Synthesis of Functionalized Calixarenes. (fishpond.co.nz)
  • Special Calixarenes, Synthesis and Properties. (fishpond.co.nz)
  • 2. Stepwise Synthesis of Calixarenes. (fishpond.co.nz)
  • This thesis describes the synthesis of several calixarene linked bis-porphyrin hosts for the binding of fullerenes. (auckland.ac.nz)
  • Marra, " Calixarene and calixresorcarene glycosides: their synthesis and biological applications," Chemical Reviews, vol. (thefreedictionary.com)
  • Chapters include cyclophanes, resorcinarene and calixarene synthesis, supramolecular metallomacrocycles and macrocycle synthesis, rotaxane and catenane synthesis, cucurbiturils and porphyrins, as well as macrocyclic drugs. (researchandmarkets.com)
  • Calixarenes resemble chalices (calix in Latin) with hydrophobic cavities that can hold smaller molecules or ions, an example of host-guest chemistry. (wikipedia.org)
  • The self-assembly behaviour of proline functionalised calixarenes were also examined.Calix[4]arenes functionalised at the wide-rim with acidic amino acids were investigated as potential crystal growth modifiers on model mineral systems and were compared with previously investigated narrow-rim analogues. (edu.au)
  • The 1H NMR spectra of L-proline calix[4]arene in the presence of small molecules (tetrahydrofuran, 1-methyl-2-pyrrolidinone, and tert-butyl alcohol) suggested that the calixarene was either acting as a host or selfassembling into larger aggregates. (edu.au)
  • Publications] S.Shinkai: 'Autoaccelerative Diazo Coupling with Calix[4]arene:Unusual Coーoperativity of the Calixarene Hydroxy Groups' J.Chem.Soc. (nii.ac.jp)
  • Gutsche, C.D.: Calixarenes. (springer.com)
  • Gutsche, C.D.: The Characterization and properties of calixarenes In: Stoddart, J.F., (ed. (springer.com)
  • Intramolecular Complexes of Calixarenes. (fishpond.co.nz)
  • Fingerprint Dive into the research topics of 'Non-covalent calixarene-amino acid complexes formed by MALDI-MS'. Together they form a unique fingerprint. (elsevier.com)
  • Non-covalent calixarene-amino acid complexes formed by MALDI-MS . Journal of the American Society for Mass Spectrometry , 13 (8), 964-974. (elsevier.com)
  • lesson hl the reaction of metal ion and stability constants of metal complexes with calixarenes: ligand mole ratio of h chemistry of a member of reaction? (umbriameteo.com)
  • Organic hosts, such as crown ethers, cyclodextrins (CDs), calixarenes (CXs), and spherands, or polymeric additives, such as poly(ethylene glycol) (PEG) and polyvinylpyrrolidone (PVP) were used as the micropore-forming templates. (google.ca)
  • 5. Ionizable Calixarene Ligands. (fishpond.co.nz)
  • Functionalized Calixarenes: New Applications as Catalysts, Ligands, and Host Molecules. (fishpond.co.nz)
  • In this paper a series of asymmetric "hybrid" compounds are prepared, which combine two galectin ligands (1) a substituted thiodigalactoside derivative and (2) an antagonist calixarene-based therapeutic agent. (uu.nl)
  • The calixarenes are synthetically versatile and well established cluster-supporting ligands, which to date have not been reported to support a calcium/manganese cluster. (edu.au)
  • Functionalisation is calixarene conformation and linker independent enabling access to a library of structures. (rsc.org)
  • Computational modeling has indicated that the removal of the hydrogen bonding motif inverts the pinched cone conformation of the calixarene scaffold, which translates to an unfavorable changes in the geometry of the binding site between the porphyrin planes. (auckland.ac.nz)
  • The facing pairs of aromatic rings of the calixarene in this conformation form two cavities that are each pre-organized for partial insertion of a Cs+ ion. (slideserve.com)
  • These experimental results indicated that the synthesized deep-cavity calixarene materials could be used to selectively remove benzo[a]pyrene and major phenolic compounds in MCS. (coresta.org)
  • They cover highly selective extractants and a better understanding of phase-transfer phenomena, supramolecular interactions in the outer coordination spheres of extracted metal ions, molecular design and metal extraction behavior of calixarene compounds as host extractants, protein extraction by the recognition of lysine residues using macrocyclic molecules, interfacial molecular aggregation in solvent extraction systems, and supramolecular aspects of stable water-in-oil microemulsions in chemical separations. (thefreedictionary.com)
  • the binding interactions between the calixarene host and the surveyed guests are similar to those operating in the complexation of organic compounds by cyclodextrin or cyclophane hosts in aqueous media. (elsevier.com)
  • A racemic mixture of the proline calixarenes gave a less stable hydrogel compared with hydrogels of the enantiopure compounds. (edu.au)
  • Calixarene Drug deleivery invistegation of Calixarene compounds with conection by histidine L and D stereochemistry', International Journal of Heterocyclic Chemistry , 3(1), pp. 58-72. (ac.ir)
  • Yahyaei, H., Hasanzadeh, N. Calixarene Drug deleivery invistegation of Calixarene compounds with conection by histidine L and D stereochemistry. (ac.ir)
  • Vicens J, Böhmer V (2012) Calixarenes: a versatile class of macrocyclic compounds. (springer.com)
  • Jin said that coating the quantum dots with calixarenes that have another chemical embedded in them can be useful for detecting metal ions and small organic compounds. (photonics.com)
  • Using cadmium-selenide quantum dots with a zinc-sulfide shell, the researchers coated the quantum dots with calixarene carboxylic acids, with four, six or eight arenes. (photonics.com)
  • For example, a quantum dot with a 530-nm emission peak had redshifts of 8, 21 and 35 nm for calixarenes with four, six and eight arenes, respectively. (photonics.com)
  • Calixarenes bear a fascinating class of macrocycles that have served broadly in molecular recognition and supramolecular chemistry. (eurekalert.org)
  • Calixarenes was the first book to be published in the `Monographs in Supramolecular Chemistry' series and is also the first complete survey available of this rapidly developing field. (rsc.org)
  • Abstract This review discusses molecular design principles of calixarene-type macrocycles for ion recognition and gives examples on the relationship between structure and selectivity, however without attempting to cover all the different approaches. (duhnnae.com)
  • Calixarene-based molecular receptors have been a widely developing area in material science and technology for the last few decades. (tubitak.gov.tr)
  • Revisiting Fluorescent Calixarenes: From Molecular Sensors to Smart Materials. (nih.gov)
  • It provides a fascinating and lively account of the history, development and applications of calixarenes, which are probably the world's most readily available synthetic molecular baskets. (rsc.org)
  • Introduction of Substituents on the `Lower Rim' of Phenol-Derived Calixarenes. (fishpond.co.nz)
  • The NMR and X-ray data were in close agreement and suggested the calixarene explores the protein surface by binding to three or more lysine side chains. (acs.org)
  • It turns out that the calixarene binds to several different lysines and explores the protein surface by hopping from one lysine to another. (healthcanal.com)
  • In addition to demonstrating potentially useful new sorbents, these materials provide some of the first experimental estimates of the energy of interaction between aqueous solutes and hydrophobic calixarenes, which have previously been inaccessible because of the insolubility of most nonionic calixarene species in water. (elsevier.com)
  • A calixarene (stick) binds to the surface of the cytochrome c protein (space fill). (acs.org)
  • This animation depicts how a calixarene might explore, and effectively camouflage, cytochrome c's surface. (acs.org)
  • The detailed data analysis of an NMR titration of 15N-labelled cytochrome c with the calixarene revealed the presence of two or more binding sites, with mM affinities. (nuigalway.ie)
  • Also described in this thesis, is the functionalization of the calixarene scaffold with ferrocene for the preparation of supramolecular triads. (auckland.ac.nz)
  • While only the thiodigalactoside part of the hybrids showed strong binding, the calixarene part was responsible for observed cytoxoxicity effects, suggesting that the calixarene moiety may also be addressing a non-galectin target. (uu.nl)
  • At the base of the calixarene are four hydroxyl groups, arranged in either a left or right handed manner. (imperial.ac.uk)
  • On the other hand, the action of the calixarene on soman, which lacks the positively charged side chain, is much less pronounced, indicating that the initial complexation step, which is particularly effective if the nerve agent is cationic, is important for rapid degradation. (atlasofscience.org)
  • Chapter Three describes modification to the calixarene scaffold to increase the flexibility of the bis-porphyrin. (auckland.ac.nz)
  • Chapter Four describes the functionalization of the wide rim of the calixarene scaffold with ferrocene via palladium catalyzed coupling reactions. (auckland.ac.nz)
  • Ertul, "Fabrication of calixarene based protein scaffold by electrospin coating for tissue engineering," Journal of Nanoscience and Nanotechnology, vol. (thefreedictionary.com)
  • According to these theoretical results,it can be drastically concluded that the dielectric permittivity of the solvent is a key factor that determines the chemical behavior of Calixarene with histidine L and D stereochemistry in solution. (ac.ir)
  • Due to the ability of calixarenes to be tailored with different functional groups they can accommodate different cytotoxic agents and thus can serve as drug delivery vehicles. (eurekalert.org)
  • Introduction of Functional Groups at the Methylene Bridges of Calixarenes. (fishpond.co.nz)
  • Calixarenes with Mixed Ligating Functional Groups. (fishpond.co.nz)
  • The magnitude of the net free energy change of adsorption varied from approximately 15 to 20 kJ/mol and was found to decrease as upper-rim calixarene functional groups became more electron-withdrawing. (elsevier.com)
  • These porphyrins have been coupled to calixarenes to construct bis-porphyrin hosts. (auckland.ac.nz)
  • The tetra alkylation of the calixarenes with methyl and butyl groups bis-porphyrin hosts displayed lower binding affinities for fullerene by an order of magnitude lower than their dialkylated counter parts. (auckland.ac.nz)
  • Calixarene surfactants are designed to structure the membrane domains of proteins through hydrophobic interactions and a network of salt bridges with the basic residues found at the cytosol-membrane interface of membrane proteins. (gbiosciences.com)
  • Inclusion Properties and Host-Guest Interactions of Calixarenes in the Solid State. (fishpond.co.nz)
  • C4v symmetric geometry for calixarene in benzene solvent, with three negative force constants. (imperial.ac.uk)
  • Mo J, Eggers PK, Yuan ZX, Raston CL, Lim LY (2016) Paclitaxel-loaded phosphonated calixarene nanovesicles as a modular drug delivery platform. (springer.com)
  • 3) In order to further substantiate the potential of sclx4 as a protein surface binder, the crystal structures of the calixarene complexed to lysozyme in its native form and in a modified form were solved to 1.7 Angstrom and 2.2 Angstrom, respectively. (nuigalway.ie)
  • Using sophisticated analytical methods, Nuclear Magnetic Resonance (NMR) spectroscopy and X-ray crystallography, Dr Crowley and colleagues were able to visualise how the calixarene sticks to the protein surface. (healthcanal.com)
  • Nimse SB, Kim T (2013) Biological applications of functionalized calixarenes. (springer.com)
  • The calixarene moreover selectively cleaves the P-S bond of VX and complete detoxification requires at least one equivalent, rendering the mode of action stoichiometric rather than catalytic. (atlasofscience.org)
  • The second was Suzuki coupling, which as has been used to couple ferrocene phenyl boronic acid to two isomers of a tetra-alkylated calixarene. (auckland.ac.nz)
  • The functionalization of ferrocene to the wide rim of the calixarene bisporphyrin resulting in minor fluorescence quenching of the porphyrin moieties suggesting the ferrocenes are at a remote distance from the porphyrins promoting the lifetime of the charge separated state through a second electron transfer. (auckland.ac.nz)
  • Polarisation curves revealed that the calixarenes are mixed-type inhibitors. (deepdyve.com)
  • Also, nuclear shielding parameters of Calixarene, such as chemical shift isotropic value (σ iso ) and the anisotropy shielding (σ aniso, ∆σ), have been taken into account using GIAO method at the HF method with the 6-31+G* basis set and at the B3LYP method with the 6-31+G* basis set in the gas phase and in different solvents such as water, DMSO, methanol, ethanol and dichloromethane. (ac.ir)
  • Bao, "Induced sensitivity and selectivity in thin-film transistor sensors via calixarene layers," Advanced Materials, vol. (thefreedictionary.com)
  • Kabouche, Z. 2012-11-03 00:00:00 Inhibition of the corrosion of mild steel in molar hydrochloric acid by two calixarenes, including the effect of inhibitor concentration and temperature, has been investigated by use of weight loss and electrochemical measurements (polarisation and impedance). (deepdyve.com)
  • Antitumor agent calixarene 0118 targets human galectin-1 as an allosteric inhibitor of carbohydrate binding. (thefreedictionary.com)
  • Although activity is not yet high enough to allow an in vivo use, this calixarene clearly represents a highly promising lead structure for synthetic scavengers, which may allow in the near future the efficient treatment of victims of organophosphonate poisonings. (atlasofscience.org)
  • We investigated the influence of calixarene C-90 and IPT-35 on plasma membrane Ca2+- pumping АТРase (PMCA), intracellular calcium homeostasis and myometrium smooth muscle strain contractions. (nih.gov)