A 13.2-kDa member of the S-100 family of calcium-binding proteins that can form homo- or heterocomplexes with CALGRANULIN A and a variety of other proteins. The calgranulin A/B heterodimer is known as LEUKOCYTE L1 ANTIGEN COMPLEX. Calgranulin B is expressed at high concentrations in GRANULOCYTES during early monocyte differentiation, and serum calgranulin B levels are elevated in many inflammatory disorders such as CYSTIC FIBROSIS.
A 10.8-kDa member of the S-100 family of calcium-binding proteins that can form homo- or heterocomplexes with CALGRANULIN B and a variety of other proteins. The calgranulin A/B heterodimer is known as LEUKOCYTE L1 ANTIGEN COMPLEX. Calgranulin A is found in many cell types including GRANULOCYTES; KERATINOCYTES; and myelomonocytes, and has been shown to act as a chemotactic substance for NEUTROPHILS. Because it is present in acute inflammation but absent in chronic inflammation, it is a useful biological marker for a number of pathological conditions.
A family of highly acidic calcium-binding proteins found in large concentration in the brain and believed to be glial in origin. They are also found in other organs in the body. They have in common the EF-hand motif (EF HAND MOTIFS) found on a number of calcium binding proteins. The name of this family derives from the property of being soluble in a 100% saturated ammonium sulfate solution.
Leukocyte L1 Antigen Complex
A member of the S-100 protein family that is present at high levels in the blood and interstitial fluid in several infectious, inflammatory, and malignant disorders, including rheumatoid arthritis, inflammatory bowel disease, and cystic fibrosis. It is a complex of a light chain (CALGRANULIN A) and a heavy chain (CALGRANULIN B). L1 binds calcium through an EF-hand motif, and has been shown to possess antimicrobial activity.
TNF-Related Apoptosis-Inducing Ligand
A transmembrane-protein belonging to the TNF family of intercellular signaling proteins. It is a widely expressed ligand that activates APOPTOSIS by binding to TNF-RELATED APOPTOSIS-INDUCING LIGAND RECEPTORS. The membrane-bound form of the protein can be cleaved by specific CYSTEINE ENDOPEPTIDASES to form a soluble ligand form.
Hypertrophy, Left Ventricular
Heart Valve Diseases
Aortic Valve Stenosis
Glycosylation End Products, Advanced
Products derived from the nonenzymatic reaction of GLUCOSE and PROTEINS in vivo that exhibit a yellow-brown pigmentation and an ability to participate in protein-protein cross-linking. These substances are involved in biological processes relating to protein turnover and it is believed that their excessive accumulation contributes to the chronic complications of DIABETES MELLITUS.
Enzyme-Linked Immunosorbent Assay
An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.
Reagent Kits, Diagnostic
Sensitivity and Specificity
A genus of deer, Rangifer, that inhabits the northern parts of Europe, Asia, and America. Caribou is the North American name; reindeer, the European. They are often domesticated and used, especially in Lapland, for drawing sleds and as a source of food. Rangifer is the only genus of the deer family in which both sexes are antlered. Most caribou inhabit arctic tundra and surrounding arboreal coniferous forests and most have seasonal shifts in migration. They are hunted extensively for their meat, skin, antlers, and other parts. (From Webster, 3d ed; Walker's Mammals of the World, 5th ed, p1397)
Trauma, Nervous System
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.
Spinal Cord Injuries
Wounds and Injuries
Salivary Proteins and Peptides
Oncogene Proteins, Viral
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
A predominantly X-linked recessive syndrome characterized by a triad of reticular skin pigmentation, nail dystrophy and leukoplakia of mucous membranes. Oral and dental abnormalities may also be present. Complications are a predisposition to malignancy and bone marrow involvement with pancytopenia. (from Int J Paediatr Dent 2000 Dec;10(4):328-34) The X-linked form is also known as Zinsser-Cole-Engman syndrome and involves the gene which encodes a highly conserved protein called dyskerin.
S100 Calcium Binding Protein beta Subunit
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.
A null mutation in the inflammation-associated S100 protein S100A8 causes early resorption of the mouse embryo. (1/326)S100A8 (also known as CP10 or MRP8) was the first member of the S100 family of calcium-binding proteins shown to be chemotactic for myeloid cells. The gene is expressed together with its dimerization partner S100A9 during myelopoiesis in the fetal liver and in adult bone marrow as well as in mature granulocytes. In this paper we show that S100A8 mRNA is expressed without S100A9 mRNA between 6.5 and 8. 5 days postcoitum within fetal cells infiltrating the deciduum in the vicinity of the ectoplacental cone. Targeted disruption of the S100A8 gene caused rapid and synchronous embryo resorption by day 9. 5 of development in 100% of homozygous null embryos. Until this point there was no evidence of developmental delay in S100A8-/- embryos and decidualization was normal. The results of PCR genotyping around 7.5-8.5 days postcoitum suggest that the null embryos are infiltrated with maternal cells before overt signs of resorption. This work is the first evidence for nonredundant function of a member of the S100 gene family and implies a role in prevention of maternal rejection of the implanting embryo. The S100A8 null provides a new model for studying fetal-maternal interactions during implantation. (+info)
S100A12 is expressed exclusively by granulocytes and acts independently from MRP8 and MRP14. (2/326)Changes in cytosolic calcium concentrations regulate a wide variety of cellular processes, and calcium-binding proteins are the key molecules in signal transduction, differentiation, and cell cycle control. S100A12, a recently described member of the S100 protein family, has been shown to be coexpressed in granulocytes and monocytes together with two other S100 proteins, MRP8 (S100A8) and MRP14 (S100A9), and a functional relationship between these three S100 proteins has been suggested. Using Western blotting, calcium overlays, intracellular flow cytometry, and cytospin preparations, we demonstrate that S100A12 expression in leukocytes is specifically restricted to granulocytes and that S100A12 represents one of the major calcium-binding proteins in these cells. S100A12, MRP8, and MRP14 translocate simultaneously from the cytosol to cytoskeletal and membrane structures in a calcium-dependent manner. However, no evidence for direct protein-protein interactions of S100A12 with either MRP8 or MRP14 or the heterodimer was found by chemical cross-linking, density gradient centrifugation, mass spectrometric measurements, or yeast two hybrid detection. Thus, S100A12 acts individually during calcium-dependent signaling, independent of MRP8, MRP14, and the heterodimer MRP8/MRP14. This granulocyte-specific signal transduction pathway may offer attractive targets for therapeutic intervention with exaggerated granulocyte activity in pathological states. (+info)
S100A8: emerging functions and regulation. (3/326)The functional importance of members of the S100 Ca2+-binding protein family is becoming apparent. Murine (m)S100A8 (initially named CP-10) is a potent chemoattractant (10(-13) to 10(-11) M) for myeloid cells and the chemotactic activity of other S100s has since been reported, suggesting a new class of chemoattractants. Murine S100A8 has been associated with a number of acute and chronic inflammatory conditions including bacterial infection, atherogenesis, and cystic fibrosis. It is expressed constitutively with S100A9 in neutrophils and is regulated by inflammatory stimulants in macrophages and microvascular endothelial cells. The lack of co-expression of S100A9 with S100A8 in activated macrophages suggests distinct functions for the proteins expressed by different cell types. Glucocorticoids up-regulate induction of mS100A8 by inflammatory mediators, and its exquisite sensitivity to oxidation suggests that it may protect against oxidative tissue damage. Inactivation of the mS100A8 gene is embryonic lethal, providing the first evidence for non-redundant function of a member of the S100 gene family. S100A8 may have an immunoregulatory role by contributing to the regulation of fetal-maternal interactions. It may play a protective role and its absence may allow infiltration by maternal cells, a process eventually manifesting as resorption. This review focuses on the variety of emerging functions attributed to murine S100A8, a protein implicated in embryogenesis, growth, differentiation, and immune and inflammatory processes. (+info)
Calcium-induced noncovalently linked tetramers of MRP8 and MRP14 detected by ultraviolet matrix-assisted laser desorption/ionization mass spectrometry. (4/326)MRP8 and MRP14 are members of the S100 family of calcium-binding proteins which play an important role during calcium-induced activation of phagocytes. Both proteins form noncovalently associated complexes as a prerequisite for biological functions. The exact stoichiometric composition of these complexes, however, has not been completely clarified yet. In the present study we show for the first time by ultraviolet matrix-assisted laser desorption/ionization mass spectrometry (UV-MALDI-MS) the calcium-induced formation of noncovalently associated (MRP8/MRP14)2 tetramers. Furthermore, we could determine posttranslational modifications of MRP8 and MRP14, the stoichiometric proportion of the two known MRP14 isoforms in the complexes as well as the number of calcium ions bound to the single MRP8 and MRP14 monomers and tetramers. MRP14 showed a higher affinity for calcium than MRP8. Upon complex formation the calcium binding increased to maximal saturation of the known EF hands in the complexed forms. Calcium-induced stabilization of the MRP8/MRP14 complexes was confirmed by DSC studies. Our results extend scope and application of UV-MALDI-MS by allowing identification of noncovalent protein complexes, the identification of minor alterations of subunits in such complexes as well as the determination of bound calcium ions. (+info)
The two calcium-binding proteins, S100A8 and S100A9, are involved in the metabolism of arachidonic acid in human neutrophils. (5/326)Recently, we identified the two myeloid related protein-8 (MRP8) (S100A8) and MRP14 (S100A9) as fatty acid-binding proteins (Klempt, M., Melkonyan, H., Nacken, W., Wiesmann, D., Holtkemper, U., and Sorg, C. (1997) FEBS Lett. 408, 81-84). Here we present data that the S100A8/A9 protein complex represents the exclusive arachidonic acid-binding proteins in human neutrophils. Binding and competition studies revealed evidence that (i) fatty acid binding was dependent on the calcium concentration; (ii) fatty acid binding was specific for the protein complex formed by S100A8 and S100A9, whereas the individual components were unable to bind fatty acids; (iii) exclusively polyunsaturated fatty acids were bound by S100A8/A9, whereas saturated (palmitic acid, stearic acid) and monounsaturated fatty acids (oleic acid) as well as arachidonic acid-derived eicosanoids (15-hydroxyeicosatetraenoic acid, prostaglandin E(2), thromboxane B(2), leukotriene B(4)) were poor competitors. Stimulation of neutrophil-like HL-60 cells with phorbol 12-myristate 13-acetate led to the secretion of S100A8/A9 protein complex, which carried the released arachidonic acid. When elevation of intracellular calcium level was induced by A23187, release of arachidonic acid occurred without secretion of S100A8/A9. In view of the unusual abundance in neutrophilic cytosol (approximately 40% of cytosolic protein) our findings assign an important role for S100A8/A9 as mediator between calcium signaling and arachidonic acid effects. Further investigations have to explore the exact function of the S100A8/A9-arachidonic acid complex both inside and outside of neutrophils. (+info)
Zinc binding reverses the calcium-induced arachidonic acid-binding capacity of the S100A8/A9 protein complex. (6/326)Analysis of the calcium-induced arachidonic acid (AA) binding to S100A8/A9 revealed that maximal AA binding was achieved at molar ratios of 1 mol S100A8 and 1 mol S100A9 and for values greater than 3 calciums per EF-hand. The AA binding capacity was not induced by the binding of other bivalent cations, such as Zn2+, Cu2+, and Mg2+, to the protein complex. In contrast, the binding of AA was prevented by the addition of either Zn2+ or Cu2+ in the presence of calcium, whereas Mg2+ failed to abrogate the AA binding capacity. The inhibitory effect was not due to blocking the formation of S100A8/A9 as demonstrated by a protein-protein interaction assay. Fluorescence measurements gave evidence that both Zn2+ and Cu2+ induce different conformational changes thereby affecting the calcium-induced formation of the AA binding pocket within the protein complex. Due to the fact that the inhibitory effect of Zn2+ was present at physiological serum concentrations, it is assumed that released S100A8/A9 may carry AA at inflammatory lesions, but not within the blood compartment. (+info)
Biochemical characterization of the murine S100A9 (MRP14) protein suggests that it is functionally equivalent to its human counterpart despite its low degree of sequence homology. (7/326)Due to the low degree of sequence similarity it has been speculated that murine and human S100A9 (MRP14), an inflammatory marker protein belonging to the S100 protein family, may have different cellular functions in mouse and man. The present study was undertaken to investigate the murine S100A9 protein (mS100A9) biochemically. We demonstrate that in murine peripheral CD11b+ cells up to 20% of the protein of the cytosolic fraction consists of mS100A9 and that several minor mS100A9 isoforms are present. Cell fractionation experiments with CD11b+ murine leukocytes showed that mS100A9 is found in the cytosol as well as in the insoluble fraction. Transient expression of a green fluorescence protein-mS100A9 fusion in mammalian cells revealed that mS100A9 is localized in neither the nucleus nor the vesicles. Recombinantly expressed murine S100A9 interacts in vitro with murine and human S100A8 in an in vitro glutathione S-transferase pull-down assay. Homodimerization was not observed. For further biochemical analysis the myeloid 32D cell line is presented as a suitable model, to study murine myeloid expressed S100 proteins. Both murine S100A9 and its dimerization partner mS100A8 are expressed at the onset of granulocyte-colony stimulating factor induced myeloid differentiation. Substantial amounts of this complex are constitutively secreted by granulocytic 32D cells into the medium. In summary, these data suggest, that the human and murine S100A9 may share a higher degree of functional homology than of sequence similarity. (+info)
Myeloid-related proteins 8 and 14 are specifically secreted during interaction of phagocytes and activated endothelium and are useful markers for monitoring disease activity in pauciarticular-onset juvenile rheumatoid arthritis. (8/326)OBJECTIVE: To analyze which physiologic stimuli induce secretion of myeloid-related protein 8 (MRP8) and MRP14, two S100 proteins expressed in neutrophils and monocytes, and to determine whether serum concentrations of these proteins are reliable parameters for monitoring inflammatory activity in pauciarticular juvenile rheumatoid arthritis (JRA). METHODS: Secretion of MRP8 and MRP14 was analyzed using a coculture system of endothelial cells and monocytes. Concentrations of MRP8/MRP14 in the serum and synovial fluid of JRA patients or culture medium were determined by enzyme-linked immunosorbent assay. The expression of MRP8 and MRP14 by leukocytes in synovial tissue or fluid was investigated using immunohistochemistry. RESULTS: MRP8 and MRP14 were specifically released during interaction of activated monocytes with tumor necrosis factor-stimulated endothelial cells. Secretion was mediated via an increase in intracellular calcium levels in monocytes. In contrast, contact with resting endothelium inhibited protein kinase C-induced secretion of the proteins by monocytes. In JRA patients, MRP8 and MRP14 were strongly expressed in infiltrating neutrophils and monocytes within the inflamed joints and could be found in significantly higher concentrations in synovial fluid (mean 42,800 ng/ml) compared with serum (2,060 ng/ml). Concentrations of MRP8/MRP14 in serum correlated well with those in synovial fluid (r = 0.78) and showed a strong correlation with disease activity (r = 0.62). After intraarticular triamcinolone therapy, the serum concentrations of MRP8/MRP14 decreased significantly in therapy responders, whereas no differences were found in patients who showed no clinical benefit. CONCLUSION: MRP8 and MRP14 are specifically released during the interaction of monocytes with inflammatory activated endothelium, probably at sites of local inflammation. Their serum concentrations represent a useful marker for monitoring local inflammation in JRA. (+info)
Gentaur Molecular :Accu \ Calgranulin B, Mab anti Human; Clone CF 557, Biotin conj. \ ACL2712B
Gentaur molecular products has all kinds of products like :search , Accu \ Calgranulin B, Mab anti_Human; Clone CF_557, Biotin conj. \ ACL2712B for more molecular products just contact us
Assay Solution. Human S100A9 ELISA Kit
CAGBMigration inhibitory factor-related protein 14; Calgranulin B; calgranulin-B; Calprotectin L1H subunit; CFAGMRP-14,60B8AG; CGLB; L1AG; LIAG; MAC387; MIF; MRP-14; MRP14Leukocyte L1 complex heavy chain; NIF; P14; protein S100-A9; S100 calcium binding protein A9 (calgranulin B); S100 calcium binding protein A9; S100 calcium-binding protein A9 (calgranulin B); S100 calcium-binding protein A9; S100A9 ...
S100A9 - Wikipedia
S100 calcium-binding protein A9 (S100A9) also known as migration inhibitory factor-related protein 14 (MRP14) or calgranulin B is a protein that in humans is encoded by the S100A9 gene. The proteins S100A8 and S100A9 form a heterodimer called calprotectin. S100-A9 is a member of the S100 family of proteins containing 2 EF hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in the inhibition of casein kinase. MRP14 complexes with MRP-8 (S100A8), another member of the S100 family of calcium-modulated proteins; together, MRP8 and MRP14 regulate myeloid cell function by binding to Toll-like receptor 4 (TLR4) and the receptor for advanced glycation end products. Altered expression of the S100A9 protein is ...
In Vivo Targeting of Inflammation-Associated Myeloid-Related Protein 8/14 Via Gadolinium Immunonanoparticles | Arteriosclerosis...
In this work, we describe novel gadolinium containing designer nanoprobes displaying antibodies against Mrp-8/14 to target inflammation in a murine model of atherosclerosis. Molecular probes targeting atherosclerosis-associated moieties have been widely used in research settings.16-19 The challenge has been to identify suitable ligands that simultaneously provide sufficient selectivity and high levels of expression and serve in a pathophysiologic context so that ligation of the target results in neutral or even beneficial effects on the disease process. Inflammation-associated calgranulins, S100A8 (Mrp8) and S100A9 (Mrp14) are upregulated following activation in response to cell contact with activated endothelium.8,20,21 Mrp-14 forms a heterodimeric complex with Mrp-8 and is isolated almost exclusively in the dimeric form (Mrp).1,3-5 Mrp-14 is functionally homologous across species, is highly expressed in atherosclerosis, and participates in amplification of inflammation, providing a ...
JCI Insight - Myeloid-related protein-14 regulates deep vein thrombosis
Using transcriptional profiling of platelets from patients presenting with acute myocardial infarction, we identified myeloid-related protein-14 (MRP-14, also known as S100A9) as an acute myocardial infarction gene and reported that platelet MRP-14 binding to platelet CD36 regulates arterial thrombosis. However, whether MRP-14 plays a role in venous thrombosis is unknown. We subjected WT and Mrp-14-deficient (Mrp-14-/-) mice to experimental models of deep vein thrombosis (DVT) by stasis ligation or partial flow restriction (stenosis) of the inferior vena cava. Thrombus weight in response to stasis ligation or stenosis was reduced significantly in Mrp-14-/- mice compared with WT mice. The adoptive transfer of WT neutrophils or platelets, or the infusion of recombinant MRP-8/14, into Mrp-14-/- mice rescued the venous thrombosis defect in Mrp-14-/- mice, indicating that neutrophil- and platelet-derived MRP-14 directly regulate venous thrombogenesis. Stimulation of neutrophils with MRP-14 induced ...
Myeloid-Related Protein-14 Is a p38 MAPK Substrate in Human Neutrophils | The Journal of Immunology
The p38 MAPK pathway participates in a number of neutrophil functions critical to generation and regulation of the inflammatory response, including chemotaxis, adherence, respiratory burst activity, degranulation, and cytoskeletal reorganization (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12). Understanding the molecular mechanisms by which p38 MAPK participates in these responses is hindered by the limited number of targets of p38 MAPK identified to date in neutrophils. MAPKAPK2 and p47phox are the only clearly identified p38 MAPK targets in human neutrophils (1, 9, 10, 21). A previous study by Lewis et al. (45) determined that 20 of 25 ERK targets identified in a global screen were not previously known. Thus, it is likely that a number of important targets of p38 MAPK that participate in regulation of neutrophil responses remain to be identified. The goal of the present study was to apply a recently developed proteomic approach that allows simultaneous identification of multiple substrates of a single ...
S100A9 / Calgranulin-B / MRP14 antibody | acris-antibodies.com
The calcium-binding, migration inhibitory factor-related proteins, MRP-8 (S100A8) and MRP-14 (S100A9) belong to the S100 protein family. The…
S100A8 Antibody, anti-human, REAfinity™ - Recombinant antibodies - MACS Antibodies - Products - Miltenyi Biotec - Norge
Clone REA917 recognizes the calcium- and zinc-binding protein S100A8, also known as migration inhibitory factor-related protein 8 (MRP-8), calprotectin, or calgranulin-A. S100A8 is mainly expressed in myeloid cells, e.g., monocytes, macrophages, and granulocytes and upregulated in different tumors, e.g., in skin, breast, colon, pancreatic, bladder, and ovarian malignancies. S100A8 is involved in the regulation of inflammatory processes and immune response and plays a role in antimicrobial, cytostatic, and chemotactic activities.Additional information: Clone REA917 displays negligible binding to Fc receptors. - Norge
Gentaur Molecular :Ray Biotech \ Recombinant Human Complement C1q Tumor Necrosis Factor-Related Protein 1 \ 228-10151-2
Gentaur molecular products has all kinds of products like :search , Ray Biotech \ Recombinant Human Complement C1q Tumor Necrosis Factor-Related Protein 1 \ 228-10151-2 for more molecular products just contact us
Carboxylated Glycans Mediate Colitis through Activation of NF-κB | The Journal of Immunology
Oligosaccharides are increasingly being recognized as important mediators of signaling in innate and adaptive immune responses (59, 60, 61, 62, 63). Considerable diversity of oligosaccharide structures provides enormous potential for information display on cell surfaces and specific recognition by different lectins. Glycans that have the same structure can also have different functions depending upon the proteins and cell types that carry them. Examples are the selectin ligands that mediate both inflammation-initiated leukocyte rolling as well as physiological lymphocyte homing and recirculation. However, not all glycan structures in mammals have been proven, much less functionally characterized. We earlier identified a family of novel carboxylated glycans on endothelial cells and macrophages that mediate inflammation. Here, we show that interfering with the interaction between these glycans and their putative lectin partners using a monoclonal anti-glycan Ab prevents the pathogenic process in a ...
Complement C1q Tumor Necrosis Factor-Related Protein 1 - Immunoassays | BioVendor Research and Diagnostics Products
BioVendor - BioVendor Research and Diagnostic Products is a developer and manufacturer of immunoassays, recombinant proteins, antibodies and endotoxin-removal products.
ORBi: Browsing ORBi
in Clinical Chemistry (2008), 54. BACKGROUND: SELDI-TOF mass spectrometry (MS) is a high-throughput proteomic approach with potential for identifying novel forms of serum biomarkers of arthritis. METHODS: We used SELDI-TOF MS to analyze ... [more ▼]. BACKGROUND: SELDI-TOF mass spectrometry (MS) is a high-throughput proteomic approach with potential for identifying novel forms of serum biomarkers of arthritis. METHODS: We used SELDI-TOF MS to analyze serum samples from patients with various forms of inflammatory arthritis. Several protein profiles were collected on different Bio-Rad Laboratories ProteinChip arrays (CM10 and IMAC-Cu(2+)) and were evaluated statistically to select potential biomarkers. RESULTS: SELDI-TOF MS analyses identified several calgranulin proteins [S100A8 (calgranulin A), S100A9 (calgranulin B), S100A9*, and S100A12 (calgranulin C)], serum amyloid A (SAA), SAA des-Arg (SAA-R), and SAA des-Arg/des-Ser (SAA-RS) as biomarkers and confirmed the results with other techniques, ...
The role of interleukin-1 beta in the pathophysiology of Schnitzlers syndrome | Arthritis Research & Therapy | Full Text
Schnitzlers syndrome (SchS) is a disabling autoinflammatory disorder, characterized by a chronic urticarial rash, an M-protein, arthralgia, and other signs of systemic inflammation. Anti-interleukin-1 (IL-1) beta antibodies are highly effective, but the pathophysiology is still largely unknown. Here we studied the effect of in-vivo IL-1 inhibition on serum markers of inflammation and cellular immune responses. Eight patients with SchS received monthly subcutaneous (s.c.) injections with 150 mg canakinumab for six months. Blood was drawn for measurement of serum markers of inflammation (12 times per patient) and for functional and phenotypic analysis of both freshly isolated and toll-like receptor (TLR)-ligand-stimulated peripheral blood mononuclear cells (PBMCs) (five times per patient). All data were compared to results of healthy controls. IL-6 levels in serum and in lysates of freshly isolated PBMCs and serum myeloid-related protein (MRP8)/14 and S100A12 levels correlated with disease activity. In
TDGF1 gene - Genetics Home Reference - NIH
From NCBI Gene:. This gene encodes an epidermal growth factor-related protein that contains a cripto, FRL-1, and cryptic domain. The encoded protein is an extracellular, membrane-bound signaling protein that plays an essential role in embryonic development and tumor growth. Mutations in this gene are associated with forebrain defects. Pseudogenes of this gene are found on chromosomes 2, 3, 6, 8, 19 and X. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]. From UniProt: ...
PAA114Mu01 | 胎盘生长因子(PLGF)多克隆抗体 | Mus musculus (Mouse，小鼠) USCN(武汉优尔生商贸有限公司)
PAA114Mu01, Polyclonal Antibody to Placenta Growth Factor (PLGF), 胎盘生长因子(PLGF)多克隆抗体, PlGF2; PGF; PGFL; Placental Growth Factor-Like; Vascular Endothelial Growth Factor-Related Protein | 仅供体外研究使用，不用于临床诊断！请索取进口关税税单及报关单！
OriGene - HDGFRP2 (NM 032631) cDNA Clone
HDGFRP2 - HDGFRP2 (untagged)-Human hepatoma-derived growth factor-related protein 2 (HDGFRP2), transcript variant 2 available for purchase from OriGene - Your Gene Company.
Recombinant Human ABR 293 Cell Lysate ABR-9122HCL - Creative BioMart
Purified Recombinant Human ABR 293 Cell Lysate from Creative Biomart. Recombinant Human ABR 293 Cell Lysate can be used for research.
Calprotectin - BÜHLMANN
BÜHLMANN is a world leader in calprotectin and offers a range of assays as diagnostic tools to determine the inflammatory disease process.
MRP8抗体[MRP8 7C12/4]|Abcam中国|Anti-MRP8抗体[MRP8 7C12/4]
MRP8小鼠单克隆抗体[MRP8 7C12/4](ab20220)可与人样本反应并经WB, ELISA, IHC, Flow Cyt实验严格验证，被1篇文献引用。所有产品均提供质保服务，中国75%以上现货。
Thymosin β4 and β10 in Sjögrens syndrome: saliva proteomics and minor salivary glands expression | Arthritis Research &...
In SS, the proteomic analysis of saliva appears to be a very useful way to assess how the autoimmune disease affects the exocrine function of salivary glands. It is an important tool for identifying biomarkers and posttranslational modifications, as well as for identifying and quantifying peptides, proteins, and neoantigens. A number of proteins have been indicated as pSS biomarkers, showing two- to threefold up- or downregulation at significantly different levels compared with healthy subjects or having an exclusive presence in SS saliva. Proteins of acinar origin (i.e., α-amylase, carbonic anhydrase VI, proline-rich proteins, prolactin-inducible protein precursor) were reduced in patients with pSS, while inflammatory phase proteins, protease inhibitors, and antimicrobial peptides (i.e., lactoferrin, β2-microglobulin, immunoglobulin κ-light chain, calgranulin B, lipocalin 1 precursor, phosphatidylethanolamine binding protein, and defensins) were increased, compared with those in healthy ...
Myeloid Cell Function in MRP-14 (S100A9) Null Mice | Molecular and Cellular Biology
In this study, we characterized mice that were deficient in the S100 protein MRP-14 (S100A9). Although there was normal expression of MRP-8 mRNA in the MRP-14−/− myeloid cells, surprisingly, no MRP-8 protein was present. The absence of MRP-8 protein could be due to inefficient translation of MPR-8 mRNA or, more likely, due to instability of MRP-8 protein in the absence of its partner, MRP-14. This finding contrasts with evidence that murine MRP-14 and MRP-8 (CP-10) exist separately in myeloid cells (28, 40) and that CP-10 alone can function as a potent chemotactic factor (28, 29). In addition, immunohistochemical studies of mouse tissues show that MRP-14 (this study) and MRP-8 (data not shown) are coexpressed in myeloid cells. In support of this finding, the heterodimer can be isolated from spleen (data not shown) and bone marrow (13). Information from physical studies with the human proteins indicates that MRP-8 and MRP-14 form a heterodimer more readily than either forms a homodimer and ...
Our previous studies illustrated that deletion of RAGE was protective in murine models of long-term diabetes-associated neuropathy (14,15). Because RAGE is critically involved in inflammatory mechanisms by virtue of its ability to bind members of the S100/calgranulin family, HMGB1 and Mac-1 (19,20,36), we tested its role in superimposed acute nerve crush injury. These studies bear clinical relevance because diabetic subjects often sustain thermal and other acute injuries to their extremities during advancing neuropathy (7-10). This present work reveals that RAGE, particularly in bone marrow cells and in diabetes, contributes to maladaptive inflammatory mechanisms after acute nerve crush.. Our data confirmed that diabetes was associated with increased expression of AGEs in the peripheral nerve in the basal state (15) and buttressed our findings that AGE levels were lower in diabetic RAGE-null mice compared with diabetic WT mice (37). We previously showed that RAGE suppresses mRNA and protein ...
Efficacy Study of ABR-215050 to Treat Prostate Cancer - Full Text View - ClinicalTrials.gov
For asymptomatic patients with Castrate-Resistant Prostate Cancer (CRPC), a window of opportunity is present. During this window of opportunity an intervention with little or no toxicity and the potential for extending the symptom-free period would be of great value to keep metastatic patients in an asymptomatic stage and thus delay the introduction of chemotherapy. The purpose of this study is to evaluate the safety and efficacy of ABR-215050 as an interventional agent for this role.. Overall survival for patients participating in study 07TASQ08 will be evaluated retrospectively using a separate study protocol 11TASQ11. ...
Ethyl quinoline-3-carboxylate 50741-46-3 Chemical Properties Physical Properties
Ethyl quinoline-3-carboxylate chemical properties, What are the chemical properties of Ethyl quinoline-3-carboxylate 50741-46-3, What are the physical properties of Ethyl quinoline-3-carboxylate ect.
22934-41-4, Quinoline-5-carbaldehyde, CAS No 22934-41-4 Quinoline-5-carbaldehyde il
CAS NO:22934-41-4; Chemical name:Quinoline-5-carbaldehyde ; physical and chemical property of 22934-41-4, Quinoline-5-carbaldehyde is provided by ChemNet.com
Methyl quinoline-3-carboxylate - Alfa Chemistry
Alfa Chemistry is the worlds leading provider for special chemicals. We offer qualified products for 53951-84-1(methyl quinoline-3-carboxylate),please inquire us for 53951-84-1(methyl quinoline-3-carboxylate).
QUINOLINE-2,3-DIOL | 26386-86-7 - 化学云数据库
QUINOLINE-2,3-DIOL,CCD编号:CCD00133569,分子式:C9 H7 N O2,分子量:161.159,同义词：QUINOLINE-2,3-DIOL; 2,3-QUINOLINEDIOL; 2,3-DIHYDROXYQUINOLINE; 分子结构,化学云数据库
DeCS Ingl s+escopo
A structurally diverse group of endogenous molecules that are multifunctional, having physiological functions inside the cell, but when released from dying cells or from cells under stress or certain immune cells, they function to activate INNATE IMMUNITY. Uncontrolled and excessive release of alarmins may contribute to INFLAMMATION; CARCINOGENESIS, and NEOPLASM METASTASIS. Alarmins are also critical for heart and nerve tissue homeostasis. . ...
PQR | (4as,10as)-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinoline-6,8-diol
You are viewing an interactive 3D depiction of the molecule (4as,10as)-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinoline-6,8-diol (C13H17NO2) from the PQR.
PQR | (4ar,10ar)-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinoline-6,8-diol
You are viewing an interactive 3D depiction of the molecule (4ar,10ar)-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinoline-6,8-diol (C13H17NO2) from the PQR.
2-Chloro-8,8-dimethyl-8,9-dihydro-7H-chromeno[2,3-b]quinoline-10,12-dione - GeoScience.net
Srinivasan, T.; Yuvaraj, P.; Reddy, B.S.R.; Velmurugan, D., 2013: 2-Chloro-8,8-dimethyl-8,9-dihydro-7H-chromeno[2,3-b]quinoline-10,12-dione
TY - JOUR. T1 - 10-hydroxy-及び10-aminopyridazino[4,5-b]-quinoline-1,4(2H,3H)-dionesの合成及びその化学発光. AU - Sasaki, Kenji. PY - 1999. Y1 - 1999. M3 - Article. VL - 50. SP - 43. EP - 46. JO - Default journal. JF - Default journal. ER - ...
Damage-associated molecular pattern - Wikipedia
Damage-associated molecular patterns (DAMPs), also known as danger-associated molecular patterns, danger signals, and alarmin, are host biomolecules that can initiate and perpetuate a noninfectious inflammatory response. In contrast, pathogen-associated molecular patterns (PAMPs) initiate and perpetuate the infectious pathogen-induced inflammatory response. A subset of DAMPs are nuclear or cytosolic proteins. When released outside the cell or exposed on the surface of the cell following tissue injury, they move from a reducing to an oxidizing milieu, which results in their denaturation. Also, following necrosis (a kind of cell death), tumor DNA is released outside the nucleus, and outside the cell, and becomes a DAMP. Two papers appearing in 1994 presaged the deeper understanding of innate immune reactivity, dictating the subsequent nature of the adaptive immune response. The first came from transplant surgeons who conducted a prospective randomized double-blind placebo-controlled trial. ...
4-HYDROXY-BENZO[H]QUINOLINE-3-CARBOXYLIC ACID 35957-14-3 Chemical Properties Physical Properties
4-HYDROXY-BENZO[H]QUINOLINE-3-CARBOXYLIC ACID chemical properties, What are the chemical properties of 4-HYDROXY-BENZO[H]QUINOLINE-3-CARBOXYLIC ACID 35957-14-3, What are the physical properties of 4-HYDROXY-BENZO[H]QUINOLINE-3-CARBOXYLIC ACID ect.
6-Bromo-2-(5-methylthiophen-2-yl)quinoline-4-carboxylic acid - Alfa Chemistry
Alfa Chemistry is the worlds leading provider for special chemicals. We offer qualified products for 5349-20-2(6-bromo-2-(5-methylthiophen-2-yl)quinoline-4-carboxylic acid),please inquire us for 5349-20-2(6-bromo-2-(5-methylthiophen-2-yl)quinoline-4-carboxylic acid).
ChemIDplus - 84371-05-1 - VKRODJWIGYCXIB-UHFFFAOYSA-N - 2,7,9-Tricarboxypyrrolo(2,3-f)quinoline-4-ol-5-one - Similar structures...
84371-05-1 - VKRODJWIGYCXIB-UHFFFAOYSA-N - 2,7,9-Tricarboxypyrrolo(2,3-f)quinoline-4-ol-5-one - Similar structures search, synonyms, formulas, resource links, and other chemical information.
1,3-dimethyl-5-sulfanylpyrimido[4,5-b]quinoline-2,4(1H,3H)-dione - C13H11N3O2S, density, melting point, boiling point,...
1,3-dimethyl-5-sulfanylpyrimido[4,5-b]quinoline-2,4(1H,3H)-dione - C13H11N3O2S, synthesis, structure, density, melting point, boiling point
6-Bromo-2-(3-isobutoxyphenyl)quinoline-4-carboxylic acid - Science Exchange
6-Bromo-2-(3-isobutoxyphenyl)quinoline-4-carboxylic acid - Science Exchange Lets You Compare Quotes From Leading Service Providers.
Calprotectin | Lab Tests Online
Calprotectin is released by white blood cells (neutrophils) in the digestive tract with inflammation. Calprotectin tests measure levels in stool to help detect conditions such as inflammatory bowel disease (IBD) and infections.
Human S100A7 Induces Mature Interleukin1α Expression by RAGE-p38 MAPK-Calpain1 Pathway in Psoriasis - pdf descargar
Human S100A7 Induces Mature Interleukin1α Expression by RAGE-p38 MAPK-Calpain1 Pathway in Psoriasis. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
Recombinant Human S100 alpha 2 protein (ab104821) References
References for Abcams Recombinant Human S100 alpha 2 protein (ab104821). Please let us know if you have used this product in your publication
Recombinant human S100A4 protein (ab83650) References | Abcam
References for Abcams Recombinant human S100A4 protein (ab83650). Please let us know if you have used this product in your publication
Quinoline-2,4-dicarboxylic acid - Elabmart.com
Relatively unreactive organic reagents should be collected in container A. If halogenated, they should be collected in container B. For solid residues use container C ...
CRP and calprotectin
Ops I meant CRP Are these different measures and tests or are they the same thing? ETA: ok I realize now that they are different. My CRP is .7 (within...
Pathogen- or damage-associated molecular patterns during nonalcoholic fatty liver disease development<...
TY - JOUR. T1 - Pathogen- or damage-associated molecular patterns during nonalcoholic fatty liver disease development. AU - Alisi, Anna. AU - Carsetti, Rita. AU - Nobili, Valerio. PY - 2011/11. Y1 - 2011/11. UR - http://www.scopus.com/inward/record.url?scp=80055057691&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=80055057691&partnerID=8YFLogxK. U2 - 10.1002/hep.24611. DO - 10.1002/hep.24611. M3 - Article. C2 - 22045668. AN - SCOPUS:80055057691. VL - 54. SP - 1500. EP - 1502. JO - Hepatology. JF - Hepatology. SN - 0270-9139. IS - 5. ER - ...
The calcium-binding protein S100A2 interacts with p53 and modulates its transcriptional activity - Zurich Open Repository and...
Head and neck squamous cell carcinoma express high levels of the EF-hand calcium-binding protein S100A2 in contrast to other tumorigenic tissues and cell lines where the expression of this protein is reduced. Subtractive hybridization of tumorigenic versus normal tumor-derived mammary epithelial cells has previously identified the S100A2 protein as potential tumor suppressor. The biological function of S100A2 in carcinogenesis, however, has not been elucidated to date. Here, we report for the first time that during recovery from hydroxyurea treatment, the S100A2 protein translocated from the cytoplasm to the nucleus and co-localized with the tumor suppressor p53 in two different oral carcinoma cells (FADU and SCC-25). Co-immunoprecipitation experiments and electrophoretic mobility shift assay showed that the interaction between S100A2 and p53 is Ca(2+)-dependent. Preliminary characterization of this interaction indicated that the region in p53 involved with binding to S100A2 is located at the C ...
Molecular cloning and characterization of spiggin : an androgen-regulated extraorganismal adhesive with structural similarities...
One of the most definitive examples of a vertebrate extraorganismal structural protein can be found in three-spined sticklebacks (Gasterosteus aculeatus). In the breeding male the kidney hypertrophies and synthesizes an adhesive protein called spiggin, which is secreted into the urinary bladder from where it is employed as a structural thread for nest building. This paper describes the first molecular characterization of spiggin and demonstrates that this adhesive is a protein complex assembled from a potential of three distinct subunits (alpha, beta, and gamma). These subunits arise by alternative splicing, and 11-ketoandrogens induce their expression in stickleback kidneys. Analysis of the predicted amino acid sequence of each subunit reveals a modular organization whose structural elements display a similarity to the multimerization domains found within von Willebrand Factor-related proteins. These results implicate that spiggin utilizes a conserved multimerization mechanism for the ...
ANTIBODY TO RAGE AND USES FOR IN VIVO IMAGING OR FOR TARGETING THERAPY - Patent application
0083] 1. Davies J R, Rudd J H, Weissberg P L. Molecular and metabolic imaging of atherosclerosis. J Nucl Med. 2004; 45:1898-1907.  2. Kislinger T, Fu C, Huber B, Qu W, Taguchi A, Yan S D, Hofmann M, Yan S F, Pischetsrieder M, Stern D, Schmidt A M. N.sup.ε-(carboxymethyl) lysine adducts of proteins are ligands for receptor for advanced glycation endproducts that activate cell signaling pathways and modulate gene expression. J Biol Chem. 1999; 274:31740-31749.  3. Hofmann M A, Drury S, Fu C, Qu W, Taguchi A, Lu Y, Avila C, Kambham N, Bierhaus A, Nawroth P, Neurath M F, Slattery T, Beach D, McClary J, Nagashima M, Morser J, Stern D, Schmidt A M. RAGE mediates a novel proinflammatory axis: a central cell surface receptor for S100/calgranulin polypeptides. Cell. 1999; 97:889-901.  4. Schmidt A M, Yan S D, Brett J, Mora R, Nowygrod R, Stern D. Regulation of human mononuclear phagocyte migration by cell surface binding proteins for AGE. J. Clin. Invest. 1993; 91:2155-2168.  5. ...
Calprotectin instability may lead to undertreatment in children with IBD | Archives of Disease in Childhood
Our results indicate a steady decline in calprotectin concentration in the first 6 days after stool collection in samples kept at room temperature. A similar slope was seen in stool extracts kept at room temperature, while the stability of calprotectin was preserved in samples stored in a refrigerator at 4°C. We did not test the superiority of one ELISA kit over another. For that, we would have needed to perform a multitude of tests. The decline in calprotectin concentration over time was observed regardless of the ELISA kit used, which makes inadvertently smoothening of the curve unlikely.. Literature on calprotectin stability under various preservation conditions is scarce. A Swedish group observed a decline in calprotectin when stool samples were stored at room temperature for 7 days but claimed that the concentration remained unchanged in the first 3 days after collection.4 A Spanish group claimed that calprotectin remained stable in stool extracts stored at room temperature for 4 days,5 as ...
Author: DeMichele, Angela / Journal: Cell / Subject: 3 selected - PubAg Search Results
Interactions between stromal fibroblasts and cancer cells generate signals for cancer progression, therapy resistance, and inflammatory responses. Although endogenous RNAs acting as damage-associated molecular patterns (DAMPs) for pattern recognition receptors (PRRs) may represent one such signal, these RNAs must remain unrecognized under non-pathological conditions. We show that triggering of str ...
QUINOLINE-5-CARBONYL AZIDE - 化学云数据库
QUINOLINE-5-CARBONYL AZIDE,CCD编号:CCD03496255,分子式:C10 H6 N4 O,分子量:198.184,同义词：QUINOLINE-5-CARBONYL AZIDE; 分子结构,化学云数据库
ethyl quinoline-4-carboxylate | C12H11NO2 - PubChem
ethyl quinoline-4-carboxylate | C12H11NO2 | CID 281193 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
ethyl 3-amino-5,6,7,8-tetrahydrofuro[2,3-b]quinoline-2-carboxylate | C14H16N2O3 - PubChem
ethyl 3-amino-5,6,7,8-tetrahydrofuro[2,3-b]quinoline-2-carboxylate | C14H16N2O3 | CID 1977359 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
quinoline-6-carbohydrazide | VWR
Learn more about quinoline-6-carbohydrazide. We enable science by offering product choice, services, process excellence and our people make it happen.
Calcium Ion Gradients Modulate the Zinc Affinity and Antibacterial Activity of Human Calprotectin
Calprotectin (CP) is an antimicrobial protein produced and released by neutrophils that inhibits the growth of pathogenic microorganisms by sequestering essential metal nutrients in the extracellular space. In this work, spectroscopic and thermodynamic metal-binding studies are presented to delineate the zinc-binding properties of CP. Unique optical absorption and EPR spectroscopic signatures for the interfacial His3Asp and His4 sites of human calprotectin are identified by using Co(II) as a spectroscopic probe. Zinc competition titrations employing chromophoric Zn(II) indicators provide a 2:1 Zn(II):CP stoichiometry, confirm that the His[subscript 3]Asp and His[subscript 4] sites of CP coordinate Zn(II), and reveal that the Zn(II) affinity of both sites is calcium-dependent. The calcium-insensitive Zn(II) competitor ZP4 affords dissociation constants of K[subscript d1] = 133 ± 58 pM and K[subscript d2] = 185 ± 219 nM for CP in the absence of Ca(II). These values decrease to K[subscript d1] ...
BCL2A1 Is A Survival and Immortalization Factor for Primitive Myeloid Hematopoietic Cells. | Blood | American Society of...
Abstract. We recently reported development of an acute myeloid leukemia in a rhesus macaque transplanted with autologous CD34+ cells transduced with a murine s
Calgranulin Brophy MB, Nolan EM (March 2015). "Manganese and microbial pathogenesis: sequestration by the Mammalian immune ...
Advanced glycation end-product
... a central cell surface receptor for S100/calgranulin polypeptides". Cell. 97 (7): 889-901. doi:10.1016/S0092-8674(00)80801-6. ...
Other names for calprotectin include MRP8-MRP14, calgranulin A and B, cystic fibrosis antigen, L1, 60BB antigen, and 27E10 ...
List of MeSH codes (D23)
... calgranulin a MeSH D23.050.301.562.200 - calgranulin b MeSH D23.050.301.593 - lymphocyte antigen 96 MeSH D23.050.301.625 - ...
List of MeSH codes (D12.776.641)
... calgranulin a MeSH D12.776.641.655.500.200 - calgranulin b The list continues at List of MeSH codes (D12.776.660).. ...
Kidney stone disease
Other endogenous inhibitors include calgranulin (an S-100 calcium binding protein), Tamm-Horsfall protein, glycosaminoglycans, ... Considering its extremely high levels of inhibition of growth and aggregation of calcium oxalate crystals, calgranulin might be ... some researchers have found that calgranulin, a protein formed in the kidney, is a potent inhibitor of the in vivo formation of ...
S100A8 (calgranulin A) S100A9 (calgranulin B) S100A12 (calgranulin C) Some in vitro evidence suggests that calgranulin can ... Calgranulin+A at the US National Library of Medicine Medical Subject Headings (MeSH) Calgranulin+B at the US National Library ... Calgranulin is an S100 calcium-binding protein that is expressed in multiple cell types, including renal epithelial cells and ... Measurement of faecal calprotectin Pillay S, Asplin J, Coe F (1 August 1998). "Evidence that calgranulin is produced by kidney ...
Ankylosing spondylitis: A version of the HLA-B gene called HLA-B27 increases the risk of developing ankylosing spondylitis. It is uncertain how HLA-B27 causes this increased risk. Researchers speculate that HLA-B27 may abnormally display to the immune system peptides that trigger arthritis. Other research suggests that joint inflammation characteristic of this disorder may result from improper folding of the HLA-B27 protein or the presence of abnormal forms of the protein on the cell surface. Although most patients with ankylosing spondylitis have the HLA-B27 variation, many people with this particular variation never develop the disorder. Other genetic and environmental factors are likely to affect the chances of developing ankylosing spondylitis and influence its progression. HLA-B27 is associated with the spondyloarthropathies, a group of disorders that includes ankylosing spondylitis and other inflammatory joint diseases. Some of these diseases are associated with a common skin condition ...
Human leukocyte antigen
The human leukocyte antigen (HLA) system or complex is a gene complex encoding the major histocompatibility complex (MHC) proteins in humans. These cell-surface proteins are responsible for the regulation of the immune system in humans. The HLA gene complex resides on a 3 Mbp stretch within chromosome 6p21. HLA genes are highly polymorphic, which means that they have many different alleles, allowing them to fine-tune the adaptive immune system. The proteins encoded by certain genes are also known as antigens, as a result of their historic discovery as factors in organ transplants. Different classes have different functions:. HLAs corresponding to MHC class I (A, B, and C) present peptides from inside the cell. For example, if the cell is infected by a virus, the HLA system brings fragments of the virus to the surface of the cell so that the cell can be destroyed by the immune system. These peptides are produced from digested proteins that are broken down in the proteasomes. In general, these ...
GAP43, is a nervous tissue-specific cytoplasmic protein that can be attached to the membrane via a dual palmitoylation sequence on cysteines 3 and 4. This sequence targets GAP43 to lipid rafts. It is a major protein kinase C (PKC) substrate and is considered to play a key role in neurite formation, regeneration, and plasticity. The role of GAP-43 in CNS development is not limited to effects on axons: It is also a component of the centrosome, and differentiating neurons that do not express GAP-43 show mislocalization of the centrosome and mitotic spindles, particularly in neurogenic cell divisions. As a consequence, in the cerebellum, the neuronal precursor pool fails to expand normally and the cerebellum is significantly smaller.. Several different laboratories studying the same protein, now called GAP43, initially used different names. It was designated F1, then B-50, then GAP43, pp46, and finally neuromodulin, each name reflecting a different function of the same molecule. F1 was ...
MHC class I
The peptide translocation from the cytosol into the lumen of the ER is accomplished by the transporter associated with antigen processing (TAP). TAP is a member of the ABC transporter family and is a heterodimeric multimembrane-spanning polypeptide consisting of TAP1 and TAP2. The two subunits form a peptide binding site and two ATP binding sites that face the cytosol. TAP binds peptides on the cytoplasmic side and translocates them under ATP consumption into the lumen of the ER. The MHC class I molecule is then, in turn, loaded with peptides in the lumen of the ER. The peptide-loading process involves several other molecules that form a large multimeric complex called the Peptide loading complex consisting of TAP, tapasin, calreticulin, calnexin, and Erp57 (PDIA3). Calnexin acts to stabilize the class I MHC α chains prior to β2m binding. Following complete assembly of the MHC molecule, calnexin dissociates. The MHC molecule lacking a bound peptide is inherently unstable and requires the ...
Calgranulin - Wikipedia
S100A8 (calgranulin A) S100A9 (calgranulin B) S100A12 (calgranulin C) Some in vitro evidence suggests that calgranulin can ... Calgranulin+A at the US National Library of Medicine Medical Subject Headings (MeSH) Calgranulin+B at the US National Library ... Calgranulin is an S100 calcium-binding protein that is expressed in multiple cell types, including renal epithelial cells and ... Measurement of faecal calprotectin Pillay S, Asplin J, Coe F (1 August 1998). "Evidence that calgranulin is produced by kidney ...
Calgranulin-B | definition of calgranulin-B by Medical dictionary
... calgranulin-B explanation free. What is calgranulin-B? Meaning of calgranulin-B medical term. What does calgranulin-B mean? ... Looking for online definition of calgranulin-B in the Medical Dictionary? ... Calgranulin-B , definition of calgranulin-B by Medical dictionary https://medical-dictionary.thefreedictionary.com/calgranulin- ... redirected from calgranulin-B) S100A9. A gene on chromosome 1q21 that encodes a member of the S100 family of proteins, which ...
Study of Calgranulin A/B Levels in Patients With Newly Diagnosed Stage I,II,III Breast Cancer - Tabular View - ClinicalTrials...
RATIONALE: Measuring levels of calgranulin A and calgranulin B in the blood of patients with breast cancer in the laboratory ... PURPOSE: This laboratory study is measuring calgranulin A and calgranulin B levels in the blood of patients with newly ... Blood draw following diagnosis of breast cancer to assess levels of circulating tumor markers, calgranulin A and calgranulin B. ... Correlation between circulating levels of calgranulin A and calgranulin B and the presence of estrogen receptor negative breast ...
Calgranulin B | Semantic Scholar
The calgranulin A/B heterodimer is known as LEUKOCYTE L1 ANTIGEN COMPLEX. Calgranulin B is expressed at high concentrations in ... or heterocomplexes with CALGRANULIN A and a variety of other proteins. ... GRANULOCYTES during early monocyte differentiation, and serum calgranulin B levels are elevated in many inflammatory disorders ... Cellular Distribution and Gene Expression Pattern of Metastasin (S100A4), Calgranulin A (S100A8), and Calgranulin B (S100A9) in ...
S100A9 / Calgranulin-B / MRP14 antibody | acris-antibodies.com
Background of S100A9 / Calgranulin-B / MRP14 antibody. The calcium-binding, migration inhibitory factor-related proteins, MRP-8 ... Human tonsil Frozen section stained with Biotin conjugated S100A9 / Calgranulin-B / MRP14 Antibody Cat.-No BM4026B. *BM4026B ... Alternative names for S100A9 / Calgranulin-B / MRP14 antibody. S100-A9, CAGB, MRP-14, S100 calcium-binding protein A9, ...
S100/Calgranulin-Mediated Inflammation Accelerates Left Ventricular Hypertrophy and Aortic Valve Sclerosis in Chronic Kidney...
S100/Calgranulin-Mediated Inflammation Accelerates Left Ventricular Hypertrophy and Aortic Valve Sclerosis in Chronic Kidney ... S100/Calgranulin-Mediated Inflammation Accelerates Left Ventricular Hypertrophy and Aortic Valve Sclerosis in Chronic Kidney ... S100/Calgranulin-Mediated Inflammation Accelerates Left Ventricular Hypertrophy and Aortic Valve Sclerosis in Chronic Kidney ... S100/Calgranulin-Mediated Inflammation Accelerates Left Ventricular Hypertrophy and Aortic Valve Sclerosis in Chronic Kidney ...
"The Roles of Calprotectin and Calgranulin C in <i>Campylobacter jejuni" by Janette...
Additionally, in response to infection, the neutrophil protein calgranulin C (S100A12) was found to be increased in the feces ... Additionally, in response to infection, the neutrophil protein calgranulin C (S100A12) was found to be increased in the feces ... Shank, Janette Marie, "The Roles of Calprotectin and Calgranulin C in Campylobacter jejuni Infection. " Masters Thesis, ...
S100A12 (S100 calcium-binding protein A12, Calgranulin-C, CAGC, CGRP, Neutrophil S100 protein, Calcium-binding protein in...
S100A12 (EN-RAGE, calgranulin) is a member of the S100 protein family, which, in humans, consists of twenty five EF-hand (alpha ... You are here: Home Products by Molecule of Interest S100A12 (S100 calcium-binding protein A12, Calgranulin-C, CAGC, CGRP, ... References to S100A12 (S100 calcium-binding protein A12, Calgranulin-C, CAGC, CGRP, Neutrophil S100 protein, Calcium-binding ... S100A12 (S100 calcium-binding protein A12, Calgranulin-C, CAGC, CGRP, Neutrophil S100 protein, Calcium-binding protein in ...
Gentaur Molecular :EIAab \ ELISA Calgranulin-B,Migration inhibitory factor-related protein 14,MRP14,MRP-14,Oryctolagus...
ELISA Calgranulin-B,Migration inhibitory factor-related protein 14,MRP14,MRP-14,Oryctolagus cuniculus,p14,Protein S100-A9, ... ELISA Calgranulin-B,Migration inhibitory factor-related protein 14,MRP14,MRP-14,Oryctolagus cuniculus,p14,Protein S100-A9, ... Product name : ELISA Calgranulin-B,Migration inhibitory factor-related protein 14,MRP14,MRP-14,Oryctolagus cuniculus,p14, ... E1793Rb ELISA Calgranulin-B,Migration inhibitory factor-related protein 14,MRP14,MRP-14,Oryctolagus cuniculus,p14,Protein S100- ...
Gentaur Molecular :Accu \ Calgranulin B, Mab anti Human; Clone CF 557, Biotin conj. \ ACL2712B
Calgranulin B, Mab anti_Human; Clone CF_557, Biotin conj. \ ACL2712B for more molecular products just contact us ... Index / Accu / Calgranulin B, Mab anti_Human; Clone CF_557, Biotin conj. / Product Detail : ACL2712B Calgranulin B, Mab anti_ ... We have also other products like : Calgranulin B, Mab anti_Human; Clone CF_557, Biotin conj.. Related products : Calgranulin B ... Calgranulin B, Mab anti_Human; Clone CF_557, Biotin conj. Human samples 80 % of the research is conducted on human samples. ...
"Identification of myeloperoxidase, alpha-defensin and calgranulin in c" by Shamim Mushtaq, Anwar Ali Siddiqui et al.
Tandem mass spectrometry analysis identified them asmyeloperoxidase chain A (MPO-A), alpha-defensin, and calgranulin. ELISA, ... Tandem mass spectrometry analysis identified them asmyeloperoxidase chain A (MPO-A), alpha-defensin, and calgranulin. ELISA, ... Identification of myeloperoxidase, alpha-defensin and calgranulin in calcium oxalate renal stones. ... alpha-defensin and calgranulin in calcium oxalate renal stones.. Clinica Chemica Acta: International Journal of Clinical ...
Anti-CP-10 Antibody Products | Biocompare.com
Chicken S100A8 (S100 Calcium Binding Protein A8/Calgranulin A) ELISA Kit Manufacturers in Delhi
S100 Calcium Binding Protein A8/Calgranulin A) ELISA Kit OSCAR DIAGNOSTIC SERVICES PVT. LTD.is an India based Company in Delhi. ... Chicken S100A8 (S100 Calcium Binding Protein A8/Calgranulin A) ELISA Kit » Chicken S100A8 (S100 Calcium Binding Protein A8/ ... Calgranulin A) ELISA Kit. Chicken S100A8 (S100 Calcium Binding Protein A8/Calgranulin A) ELISA Kit. Chicken S100A8 (S100 ... Chicken S100A8 (S100 Calcium Binding Protein A8/Calgranulin A) ELISA Kit. Chicken S100A8 (S100 Calcium Binding Protein A8/ ...
CP-10 ELISA Kits | Biocompare.com
Patent US8492107 - Neural proteins as biomarkers for nervous system injury and other neural ... - Google Patents
Calgranulin AB, alpha-Synuelein (P37377), beta-Synuclein (Q63754), HNP 22; Neural nuclear proteins: NeuN-1, S/G(2) nuclear ... Calgranulin AB, alpha-Synuclein (P37377), beta-Synuclein (Q63754), HNP 22; Neural nuclear proteins: NeuN-1, S/G(2) nuclear ... Calgranulin AB, alpha-Synuclein (P37377), beta-Synuclein (Q63754), HNP 22; Neural nuclear proteins: NeuN-1, S/G(2) nuclear ... Calgranulin AB, alpha-Synuclein (P37377), beta-Synuclein (Q63754), HNP 22; Neural nuclear proteins: NeuN-1, S/G(2) nuclear ...
SALIVARY PROTEIN BIOMARKERS FOR HUMAN ORAL CANCER - The Regents of the University of California
4. The method of any one of claims 1 to 3, wherein said method comprises the detection of M2BP, calgranulin B, CD59, profilin, ... In another particular embodiment, the methods of the invention comprise the detection of M2BP, calgranulin B, CD59, profilin, ... The discovered candidate biomarkers include calgranulin A, serum amyloid A-4 protein and related isoforms, haptoglobin-related ... Further validation of calgranulin A by ELISA (n=20 for each group, p=0.039) and tetranectin by immunoblotting (n=35 for each ...
Serum calgranulin C is a highly sensitive autoinflammation activity indicator in patients with familial periodic fevers]. -...
A method for isolating and analyzing human mRNA from newborn stool
CD11b+Ly6C++Ly6G- cells show distinct function in mice with chronic inflammation or tumor burden
S100A8 (calgranulin A, MRP8) and S100A9 (calgranulin B, MRP14) are members of the calcium-binding protein family S100 genes (54 ... 33), the proto-oncogene Bcl-2, and two calcium-binding protein genes, S100A8 (calgranulin A, MRP8) and S100A9 (calgranulin B, ... calgranulin A, MRP8) and S100A9 (calgranulin B, MRP14), apoptosis inhibitor BIRC5 (surviving, baculoviral IAP repeat-containing ... Similarly, calgranulin expression extended from the intermediate layers to superficial cells as the CIN grade progressed (P , ...
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Recombinant Human S100A9 protein (ab95909) | Abcam
Diabetes insipidus emedicine treatment
Molecular and Cellular Mechanisms of Cardiovascular Disorders in Diabetes. - PubMed - NCBI
S100A9 Gene - GeneCards | S10A9 Protein | S10A9 Antibody
Anti-S100A12/CGRP antibody (ab231722) | Abcam
Multidimensional analyses reveal modulation of adaptive and innate immune subsets by tuberculosis vaccines | Communications...
S100A8/9 induces cell death via a novel, RAGE-independent pathway that involves selective release of Smac/DIABLO and Omi/HtrA2
SCOPe 2.06: Structural Classification of Proteins - extended
Compound: calgranulin c. Species: Homo sapiens [TaxId:9606]. Database cross-references and differences (RAF-indexed): *Uniprot ... Compound: calgranulin c. Species: Homo sapiens [TaxId:9606]. Database cross-references and differences (RAF-indexed): *Uniprot ... Compound: calgranulin c. Species: Homo sapiens [TaxId:9606]. Database cross-references and differences (RAF-indexed): *Uniprot ... Compound: calgranulin c. Species: Homo sapiens [TaxId:9606]. Database cross-references and differences (RAF-indexed): *Uniprot ...
- S100A8 (calgranulin A) S100A9 (calgranulin B) S100A12 (calgranulin C) Some in vitro evidence suggests that calgranulin can inhibit the precipitation of calcium oxalate in a urine-like environment at calgranulin concentrations below physiological concentrations. (wikipedia.org)
- Calgranulin B (S100A9/MRP14): A Key Molecule in Idiopathic Pulmonary Fibrosis? (semanticscholar.org)
- Human tonsil Frozen section stained with Biotin conjugated S100A9 / Calgranulin-B / MRP14 Antibody Cat. (acris-antibodies.com)
- Approach and Results- A bacterial artificial chromosome of the human S100/calgranulin gene cluster containing the genes and regulatory elements for S100A8, S100A9, and S100A12 was expressed in C57BL/6J mouse (hBAC-S100) to generate a novel humanized mouse model. (ahajournals.org)
- ELISA Calgranulin-B,Migration inhibitory factor-related protein 14,MRP14,MRP-14,Oryctolagus cuniculus,p14,Protein S100-A9,Rabbit,S100 calcium-binding protein A9,S100A9 rabbit polyclonal These antibodies are very stable and can be stored up to 2 months at fridge temperature under 10C. (antibody-antibodies.com)
- S100 calcium-binding protein A9 (S100A9) also known as migration inhibitory factor-related protein 14 (MRP14) or calgranulin B is a protein that in humans is encoded by the S100A9 gene. (wikipedia.org)
- S100A9 (myeloid-related protein 14, MRP 14 or calgranulin B) has been implicated in the abnormal differentiation of myeloid cells in the stroma of cancer, and to leukemia progression. (wikipedia.org)
- Outside of malignancy, S100A9 in association with its dimerization partner, S100A8 (MRP8 or calgranulin A) signals for lymphocyte recruitment in sites of inflammation. (wikipedia.org)
- These transgenic mice express S100a9 (S100 calcium binding protein A9 (calgranulin B)), a myeloid-related protein, and GFP under the control of the hematopoietic cell-specific H2-K promoter. (jax.org)
- Human MRP14, Granulocytes, stimulated Monocytes and Macrophages: This clone identifies the Ca2+-binding 14 kDa subunit of the inflammatory L-1 protein complex, also called S100A9 or Calgranulin B. It is useful for the characterization of circulating granulocytes or inflammatory infiltrates of the myelo-monocytic lineage which express MRP14 differently depending on the inflammatory status of the disease. (antibodies-online.com)
- MRP8 (Calgranulin A, 10.8 kDa) and MRP14 (Calgranulin B, 13.2 kDa) belong to the S-100 protein family (S100A8 and S100A9) and can form Ca2+ dependent homo- or hetero-complexes of various composition. (acris-antibodies.com)
- Mrp exists as a heterodimer of Mrp-14 (S100A9 or calgranulin B) and Mrp-8 (S100A8 or calgranulin A), with prior studies demonstrating an important role for the Mrp complex in the inflammatory response to injury. (ahajournals.org)
- Additionally, in response to infection, the neutrophil protein calgranulin C (S100A12) was found to be increased in the feces of both ferrets and humans infected with C. jejuni , while calprotectin (another neutrophil protein) was not. (tennessee.edu)
- S100A12 (EN-RAGE, calgranulin) is a member of the S100 protein family, which, in humans, consists of twenty five EF-hand (alpha helix-loop-alpha helix), calcium-binding proteins, of which the vast majority is in homodimer, heterodimer or more complex forms. (biovendor.com)
- 1999) reported that RAGE is a central cell surface receptor for S100A12, which they referred to as EN-RAGE (Extracellular Newly identified RAGE-binding protein), and related members of the S100/calgranulin superfamily. (biovendor.com)
- Interaction of EN-RAGE (S100A12) with cellular RAGE on endothelium, mononuclear phagocytes, and lymphocytes triggered cellular activation, with generation of key proinflammatory mediators. (biovendor.com)
- S100A12, also known as extracellular newly identified RAGE or calgranulin C, is a proinflammatory protein predominantly secreted by neutrophils 12 , 13 . (jrheum.org)
- This includes a member of the S100/calgranulin family termed S100A12, calgranulin C, or extracellular newly identified RAGE-binding proteins (EN-RAGE). (ahajournals.org)
- MRP8 (10.8 kDa) is also known as p8, L1 light chain, calgranulin A, and cystic fibrosis antigen (CFA). (biomedcentral.com)
- This antibody identifies the Ca2+-binding light subunit of the inflammatory L-1 protein complex, also called S100A8 or Calgranulin A. It is useful for the identification of the 8 kDa subunit in various immunological techniques. (antikoerper-online.de)
- The term calprotectin specifically refers to the Calgranulin A and B heterodimer that is formed by a non-covalent interaction. (intechopen.com)
- Excessive amounts of calgranulin A/B in extracellular compartments of tissues correlates with a variety of inflammatory disorders. (intechopen.com)
- Expression and release of calgranulin A/B in the extracellular milieu can be triggered by IL-1α. (intechopen.com)
- Extracellular calgranulin A/B can then bind to and activate toll like receptor 4 (TLR 4), which in turn initiates further expression of pro-inflammatory mediators such as IL-1, IL-6, and IL-8. (intechopen.com)
- Calgranulin A expression may also be important in promoting the induction of a regulatory macrophage phenotype that down-regulates inflammation and facilitates a healing response. (intechopen.com)
- For example, granulocytes depend on the intracellular calgranulin A/B complex to adequately participate in cell adhesion, cytokinesis, cytokine secretion, and activation of the respiratory burst. (intechopen.com)
- Patients undergo a blood draw following diagnosis of breast cancer to assess levels of circulating tumor markers, calgranulin A and calgranulin B. Serum samples are evaluated by enzyme-linked immunosorbent assay for tumor marker expression. (clinicaltrials.gov)
- Serum calgranulin C is a highly sensitive autoinflammation activity indicator in patients with familial periodic fevers]. (cdc.gov)
- RATIONALE: Measuring levels of calgranulin A and calgranulin B in the blood of patients with breast cancer in the laboratory may help doctors identify and learn more about biomarkers related to breast cancer. (clinicaltrials.gov)
- 3. The method of any one of claim 1 or 2, wherein at least one of said oral cancer biomarkers is selected from the group consisting of M2BP, calgranulin B, CD59, profilin, and catalase. (freepatentsonline.com)
- In the urinary tract, over expression of calgranulin A is not specific for infection. (intechopen.com)
- Determine circulating levels of calgranulin A and calgranulin B in patients with estrogen receptor negative or estrogen receptor positive, newly diagnosed, primary stage I-III adenocarcinoma of the breast. (clinicaltrials.gov)
- Conclusions- Myeloid-derived human S100/calgranulin is associated with the development of cardiac hypertrophy and ectopic cardiac calcification in a receptor for advanced glycation end products-dependent manner in a mouse model of CKD. (ahajournals.org)
- In murine models, blockade of EN-RAGE/RAGE quenched delayed-type hypersensitivity and inflammatory colitis by arresting activation of central signaling pathways and expression of inflammatory gene mediators. (biovendor.com)
- The interaction of these cytokines and chemokines with calgranulin A can create an autocrine / paracine mediated pro-inflammatory feedback loop that does not necessarily resolve infection. (intechopen.com)
- Tandem mass spectrometry analysis identified them asmyeloperoxidase chain A (MPO-A), alpha-defensin, and calgranulin. (aku.edu)
- Shank, Janette Marie, "The Roles of Calprotectin and Calgranulin C in Campylobacter jejuni Infection. (tennessee.edu)
- Identification of myeloperoxidase, alpha-defensin and calgranulin in c" by Shamim Mushtaq, Anwar Ali Siddiqui et al. (aku.edu)
- We tested the hypothesis that human S100/calgranulin would accelerate cardiovascular disease in mice subjected to CKD. (ahajournals.org)
- However, the role of calgranulin in the stone formation process has not been evaluated. (wikipedia.org)
- Blood draw following diagnosis of breast cancer to assess levels of circulating tumor markers, calgranulin A and calgranulin B. (clinicaltrials.gov)
- Calgranulin A/B can down-regulate immune responses through inhibition of immunoglobulin production by lymphocytes and induction of myeloid derived suppressor cells. (intechopen.com)
- In addition, calgranulin induces apoptosis in cells that stimulate the inflammatory cascade. (intechopen.com)
- Calgranulin is expressed in macrophages and epithelial cells. (scbt.com)
- The 2B10 monoclonal antibody specifically binds to S100 calcium-binding protein A9 (S100A9), which is also known as Migration inhibitory factor-related protein 14 (MRP-14) or Calgranulin-B (CAGB). (fishersci.com)
- Outside of malignancy, S100A9 in association with its dimerization partner, S100A8 (MRP8 or calgranulin A) signals for lymphocyte recruitment in sites of inflammation. (abbkine.com)