Calgranulin b. Medical search

A 13.2-kDa member of the S-100 family of calcium-binding proteins that can form homo- or heterocomplexes with CALGRANULIN A and a variety of other proteins. The calgranulin A/B heterodimer is known as LEUKOCYTE L1 ANTIGEN COMPLEX. Calgranulin B is expressed at high concentrations in GRANULOCYTES during early monocyte differentiation, and serum calgranulin B levels are elevated in many inflammatory disorders such as CYSTIC FIBROSIS.

A 10.8-kDa member of the S-100 family of calcium-binding proteins that can form homo- or heterocomplexes with CALGRANULIN B and a variety of other proteins. The calgranulin A/B heterodimer is known as LEUKOCYTE L1 ANTIGEN COMPLEX. Calgranulin A is found in many cell types including GRANULOCYTES; KERATINOCYTES; and myelomonocytes, and has been shown to act as a chemotactic substance for NEUTROPHILS. Because it is present in acute inflammation but absent in chronic inflammation, it is a useful biological marker for a number of pathological conditions.

A family of highly acidic calcium-binding proteins found in large concentration in the brain and believed to be glial in origin. They are also found in other organs in the body. They have in common the EF-hand motif (EF HAND MOTIFS) found on a number of calcium binding proteins. The name of this family derives from the property of being soluble in a 100% saturated ammonium sulfate solution.

A member of the S-100 protein family that is present at high levels in the blood and interstitial fluid in several infectious, inflammatory, and malignant disorders, including rheumatoid arthritis, inflammatory bowel disease, and cystic fibrosis. It is a complex of a light chain (CALGRANULIN A) and a heavy chain (CALGRANULIN B). L1 binds calcium through an EF-hand motif, and has been shown to possess antimicrobial activity.

Proteins to which calcium ions are bound. They can act as transport proteins, regulator proteins, or activator proteins. They typically contain EF HAND MOTIFS.

Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).

A transmembrane-protein belonging to the TNF family of intercellular signaling proteins. It is a widely expressed ligand that activates APOPTOSIS by binding to TNF-RELATED APOPTOSIS-INDUCING LIGAND RECEPTORS. The membrane-bound form of the protein can be cleaved by specific CYSTEINE ENDOPEPTIDASES to form a soluble ligand form.

The property of antibodies which enables them to react with some ANTIGENIC DETERMINANTS and not with others. Specificity is dependent on chemical composition, physical forces, and molecular structure at the binding site.

Immunoglobulins produced in response to VIRAL ANTIGENS.

The valve between the left ventricle and the ascending aorta which prevents backflow into the left ventricle.

A pathological process consisting of hardening or fibrosis of an anatomical structure, often a vessel or a nerve.

Enlargement of the LEFT VENTRICLE of the heart. This increase in ventricular mass is attributed to sustained abnormal pressure or volume loads and is a contributor to cardiovascular morbidity and mortality.

Pathological conditions involving any of the various HEART VALVES and the associated structures (PAPILLARY MUSCLES and CHORDAE TENDINEAE).

A pathological constriction that can occur above (supravalvular stenosis), below (subvalvular stenosis), or at the AORTIC VALVE. It is characterized by restricted outflow from the LEFT VENTRICLE into the AORTA.

Products derived from the nonenzymatic reaction of GLUCOSE and PROTEINS in vivo that exhibit a yellow-brown pigmentation and an ability to participate in protein-protein cross-linking. These substances are involved in biological processes relating to protein turnover and it is believed that their excessive accumulation contributes to the chronic complications of DIABETES MELLITUS.

Pathologic deposition of calcium salts in tissues.

20-carbon saturated monocarboxylic acids.

A water-soluble, enzyme co-factor present in minute amounts in every living cell. It occurs mainly bound to proteins or polypeptides and is abundant in liver, kidney, pancreas, yeast, and milk.

An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.

Commercially prepared reagent sets, with accessory devices, containing all of the major components and literature necessary to perform one or more designated diagnostic tests or procedures. They may be for laboratory or personal use.

Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)

A genus of deer, Rangifer, that inhabits the northern parts of Europe, Asia, and America. Caribou is the North American name; reindeer, the European. They are often domesticated and used, especially in Lapland, for drawing sleds and as a source of food. Rangifer is the only genus of the deer family in which both sexes are antlered. Most caribou inhabit arctic tundra and surrounding arboreal coniferous forests and most have seasonal shifts in migration. They are hunted extensively for their meat, skin, antlers, and other parts. (From Webster, 3d ed; Walker's Mammals of the World, 5th ed, p1397)

A subfamily of HERPESVIRIDAE characterized by a short replication cycle. The genera include: SIMPLEXVIRUS; VARICELLOVIRUS; MAREK'S DISEASE-LIKE VIRUSES; and ILTOVIRUS.

EPIDEMIOLOGIC STUDIES based on the detection through serological testing of characteristic change in the serum level of specific ANTIBODIES. Latent subclinical infections and carrier states can thus be detected in addition to clinically overt cases.

The use of statistical methods in the analysis of a body of literature to reveal the historical development of subject fields and patterns of authorship, publication, and use. Formerly called statistical bibliography. (from The ALA Glossary of Library and Information Science, 1983)

Exclusive legal rights or privileges applied to inventions, plants, etc.

Traumatic injuries to the brain, cranial nerves, spinal cord, autonomic nervous system, or neuromuscular system, including iatrogenic injuries induced by surgical procedures.

Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.

Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.

Penetrating and non-penetrating injuries to the spinal cord resulting from traumatic external forces (e.g., WOUNDS, GUNSHOT; WHIPLASH INJURIES; etc.).

Damage inflicted on the body as the direct or indirect result of an external force, with or without disruption of structural continuity.

Proteins and peptides found in SALIVA and the SALIVARY GLANDS. Some salivary proteins such as ALPHA-AMYLASES are enzymes, but their composition varies in different individuals.

Tumors or cancer of the MOUTH.

Polyketides of up to a few dozen carbons in length, formed by chain extension of multiple PROPIONATES and oxygenated to form tetrahydrofuran and lactone rings along the length of the chain. They are found in ANNONACEAE and other PLANTS. Related compounds cyclize to MACROLIDES.

Pathological processes involving the PERIODONTIUM including the gum (GINGIVA), the alveolar bone (ALVEOLAR PROCESS), the DENTAL CEMENTUM, and the PERIODONTAL LIGAMENT.

The systematic study of the complete complement of proteins (PROTEOME) of organisms.

An essential ribonucleoprotein reverse transcriptase that adds telomeric DNA to the ends of eukaryotic CHROMOSOMES.

Products of viral oncogenes, most commonly retroviral oncogenes. They usually have transforming and often protein kinase activities.

Insertion of viral DNA into host-cell DNA. This includes integration of phage DNA into bacterial DNA; (LYSOGENY); to form a PROPHAGE or integration of retroviral DNA into cellular DNA to form a PROVIRUS.

Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.

RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.

The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.

A predominantly X-linked recessive syndrome characterized by a triad of reticular skin pigmentation, nail dystrophy and leukoplakia of mucous membranes. Oral and dental abnormalities may also be present. Complications are a predisposition to malignancy and bone marrow involvement with pancytopenia. (from Int J Paediatr Dent 2000 Dec;10(4):328-34) The X-linked form is also known as Zinsser-Cole-Engman syndrome and involves the gene which encodes a highly conserved protein called dyskerin.

Proteins obtained from ESCHERICHIA COLI.

A calcium-binding protein that is 92 AA long, contains 2 EF-hand domains, and is concentrated mainly in GLIAL CELLS. Elevation of S100B levels in brain tissue correlates with a role in neurological disorders.

Proteins prepared by recombinant DNA technology.

A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.

Antibodies produced by a single clone of cells.

The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.

Immunoglobulins produced in a response to BACTERIAL ANTIGENS.

A null mutation in the inflammation-associated S100 protein S100A8 causes early resorption of the mouse embryo. (1/326)

S100A8 (also known as CP10 or MRP8) was the first member of the S100 family of calcium-binding proteins shown to be chemotactic for myeloid cells. The gene is expressed together with its dimerization partner S100A9 during myelopoiesis in the fetal liver and in adult bone marrow as well as in mature granulocytes. In this paper we show that S100A8 mRNA is expressed without S100A9 mRNA between 6.5 and 8. 5 days postcoitum within fetal cells infiltrating the deciduum in the vicinity of the ectoplacental cone. Targeted disruption of the S100A8 gene caused rapid and synchronous embryo resorption by day 9. 5 of development in 100% of homozygous null embryos. Until this point there was no evidence of developmental delay in S100A8-/- embryos and decidualization was normal. The results of PCR genotyping around 7.5-8.5 days postcoitum suggest that the null embryos are infiltrated with maternal cells before overt signs of resorption. This work is the first evidence for nonredundant function of a member of the S100 gene family and implies a role in prevention of maternal rejection of the implanting embryo. The S100A8 null provides a new model for studying fetal-maternal interactions during implantation. (+info)

S100A12 is expressed exclusively by granulocytes and acts independently from MRP8 and MRP14. (2/326)

Changes in cytosolic calcium concentrations regulate a wide variety of cellular processes, and calcium-binding proteins are the key molecules in signal transduction, differentiation, and cell cycle control. S100A12, a recently described member of the S100 protein family, has been shown to be coexpressed in granulocytes and monocytes together with two other S100 proteins, MRP8 (S100A8) and MRP14 (S100A9), and a functional relationship between these three S100 proteins has been suggested. Using Western blotting, calcium overlays, intracellular flow cytometry, and cytospin preparations, we demonstrate that S100A12 expression in leukocytes is specifically restricted to granulocytes and that S100A12 represents one of the major calcium-binding proteins in these cells. S100A12, MRP8, and MRP14 translocate simultaneously from the cytosol to cytoskeletal and membrane structures in a calcium-dependent manner. However, no evidence for direct protein-protein interactions of S100A12 with either MRP8 or MRP14 or the heterodimer was found by chemical cross-linking, density gradient centrifugation, mass spectrometric measurements, or yeast two hybrid detection. Thus, S100A12 acts individually during calcium-dependent signaling, independent of MRP8, MRP14, and the heterodimer MRP8/MRP14. This granulocyte-specific signal transduction pathway may offer attractive targets for therapeutic intervention with exaggerated granulocyte activity in pathological states. (+info)

S100A8: emerging functions and regulation. (3/326)

The functional importance of members of the S100 Ca2+-binding protein family is becoming apparent. Murine (m)S100A8 (initially named CP-10) is a potent chemoattractant (10(-13) to 10(-11) M) for myeloid cells and the chemotactic activity of other S100s has since been reported, suggesting a new class of chemoattractants. Murine S100A8 has been associated with a number of acute and chronic inflammatory conditions including bacterial infection, atherogenesis, and cystic fibrosis. It is expressed constitutively with S100A9 in neutrophils and is regulated by inflammatory stimulants in macrophages and microvascular endothelial cells. The lack of co-expression of S100A9 with S100A8 in activated macrophages suggests distinct functions for the proteins expressed by different cell types. Glucocorticoids up-regulate induction of mS100A8 by inflammatory mediators, and its exquisite sensitivity to oxidation suggests that it may protect against oxidative tissue damage. Inactivation of the mS100A8 gene is embryonic lethal, providing the first evidence for non-redundant function of a member of the S100 gene family. S100A8 may have an immunoregulatory role by contributing to the regulation of fetal-maternal interactions. It may play a protective role and its absence may allow infiltration by maternal cells, a process eventually manifesting as resorption. This review focuses on the variety of emerging functions attributed to murine S100A8, a protein implicated in embryogenesis, growth, differentiation, and immune and inflammatory processes. (+info)

Calcium-induced noncovalently linked tetramers of MRP8 and MRP14 detected by ultraviolet matrix-assisted laser desorption/ionization mass spectrometry. (4/326)

MRP8 and MRP14 are members of the S100 family of calcium-binding proteins which play an important role during calcium-induced activation of phagocytes. Both proteins form noncovalently associated complexes as a prerequisite for biological functions. The exact stoichiometric composition of these complexes, however, has not been completely clarified yet. In the present study we show for the first time by ultraviolet matrix-assisted laser desorption/ionization mass spectrometry (UV-MALDI-MS) the calcium-induced formation of noncovalently associated (MRP8/MRP14)2 tetramers. Furthermore, we could determine posttranslational modifications of MRP8 and MRP14, the stoichiometric proportion of the two known MRP14 isoforms in the complexes as well as the number of calcium ions bound to the single MRP8 and MRP14 monomers and tetramers. MRP14 showed a higher affinity for calcium than MRP8. Upon complex formation the calcium binding increased to maximal saturation of the known EF hands in the complexed forms. Calcium-induced stabilization of the MRP8/MRP14 complexes was confirmed by DSC studies. Our results extend scope and application of UV-MALDI-MS by allowing identification of noncovalent protein complexes, the identification of minor alterations of subunits in such complexes as well as the determination of bound calcium ions. (+info)

The two calcium-binding proteins, S100A8 and S100A9, are involved in the metabolism of arachidonic acid in human neutrophils. (5/326)

Recently, we identified the two myeloid related protein-8 (MRP8) (S100A8) and MRP14 (S100A9) as fatty acid-binding proteins (Klempt, M., Melkonyan, H., Nacken, W., Wiesmann, D., Holtkemper, U., and Sorg, C. (1997) FEBS Lett. 408, 81-84). Here we present data that the S100A8/A9 protein complex represents the exclusive arachidonic acid-binding proteins in human neutrophils. Binding and competition studies revealed evidence that (i) fatty acid binding was dependent on the calcium concentration; (ii) fatty acid binding was specific for the protein complex formed by S100A8 and S100A9, whereas the individual components were unable to bind fatty acids; (iii) exclusively polyunsaturated fatty acids were bound by S100A8/A9, whereas saturated (palmitic acid, stearic acid) and monounsaturated fatty acids (oleic acid) as well as arachidonic acid-derived eicosanoids (15-hydroxyeicosatetraenoic acid, prostaglandin E(2), thromboxane B(2), leukotriene B(4)) were poor competitors. Stimulation of neutrophil-like HL-60 cells with phorbol 12-myristate 13-acetate led to the secretion of S100A8/A9 protein complex, which carried the released arachidonic acid. When elevation of intracellular calcium level was induced by A23187, release of arachidonic acid occurred without secretion of S100A8/A9. In view of the unusual abundance in neutrophilic cytosol (approximately 40% of cytosolic protein) our findings assign an important role for S100A8/A9 as mediator between calcium signaling and arachidonic acid effects. Further investigations have to explore the exact function of the S100A8/A9-arachidonic acid complex both inside and outside of neutrophils. (+info)

Zinc binding reverses the calcium-induced arachidonic acid-binding capacity of the S100A8/A9 protein complex. (6/326)

Analysis of the calcium-induced arachidonic acid (AA) binding to S100A8/A9 revealed that maximal AA binding was achieved at molar ratios of 1 mol S100A8 and 1 mol S100A9 and for values greater than 3 calciums per EF-hand. The AA binding capacity was not induced by the binding of other bivalent cations, such as Zn2+, Cu2+, and Mg2+, to the protein complex. In contrast, the binding of AA was prevented by the addition of either Zn2+ or Cu2+ in the presence of calcium, whereas Mg2+ failed to abrogate the AA binding capacity. The inhibitory effect was not due to blocking the formation of S100A8/A9 as demonstrated by a protein-protein interaction assay. Fluorescence measurements gave evidence that both Zn2+ and Cu2+ induce different conformational changes thereby affecting the calcium-induced formation of the AA binding pocket within the protein complex. Due to the fact that the inhibitory effect of Zn2+ was present at physiological serum concentrations, it is assumed that released S100A8/A9 may carry AA at inflammatory lesions, but not within the blood compartment. (+info)

Biochemical characterization of the murine S100A9 (MRP14) protein suggests that it is functionally equivalent to its human counterpart despite its low degree of sequence homology. (7/326)

Due to the low degree of sequence similarity it has been speculated that murine and human S100A9 (MRP14), an inflammatory marker protein belonging to the S100 protein family, may have different cellular functions in mouse and man. The present study was undertaken to investigate the murine S100A9 protein (mS100A9) biochemically. We demonstrate that in murine peripheral CD11b+ cells up to 20% of the protein of the cytosolic fraction consists of mS100A9 and that several minor mS100A9 isoforms are present. Cell fractionation experiments with CD11b+ murine leukocytes showed that mS100A9 is found in the cytosol as well as in the insoluble fraction. Transient expression of a green fluorescence protein-mS100A9 fusion in mammalian cells revealed that mS100A9 is localized in neither the nucleus nor the vesicles. Recombinantly expressed murine S100A9 interacts in vitro with murine and human S100A8 in an in vitro glutathione S-transferase pull-down assay. Homodimerization was not observed. For further biochemical analysis the myeloid 32D cell line is presented as a suitable model, to study murine myeloid expressed S100 proteins. Both murine S100A9 and its dimerization partner mS100A8 are expressed at the onset of granulocyte-colony stimulating factor induced myeloid differentiation. Substantial amounts of this complex are constitutively secreted by granulocytic 32D cells into the medium. In summary, these data suggest, that the human and murine S100A9 may share a higher degree of functional homology than of sequence similarity. (+info)

Myeloid-related proteins 8 and 14 are specifically secreted during interaction of phagocytes and activated endothelium and are useful markers for monitoring disease activity in pauciarticular-onset juvenile rheumatoid arthritis. (8/326)

OBJECTIVE: To analyze which physiologic stimuli induce secretion of myeloid-related protein 8 (MRP8) and MRP14, two S100 proteins expressed in neutrophils and monocytes, and to determine whether serum concentrations of these proteins are reliable parameters for monitoring inflammatory activity in pauciarticular juvenile rheumatoid arthritis (JRA). METHODS: Secretion of MRP8 and MRP14 was analyzed using a coculture system of endothelial cells and monocytes. Concentrations of MRP8/MRP14 in the serum and synovial fluid of JRA patients or culture medium were determined by enzyme-linked immunosorbent assay. The expression of MRP8 and MRP14 by leukocytes in synovial tissue or fluid was investigated using immunohistochemistry. RESULTS: MRP8 and MRP14 were specifically released during interaction of activated monocytes with tumor necrosis factor-stimulated endothelial cells. Secretion was mediated via an increase in intracellular calcium levels in monocytes. In contrast, contact with resting endothelium inhibited protein kinase C-induced secretion of the proteins by monocytes. In JRA patients, MRP8 and MRP14 were strongly expressed in infiltrating neutrophils and monocytes within the inflamed joints and could be found in significantly higher concentrations in synovial fluid (mean 42,800 ng/ml) compared with serum (2,060 ng/ml). Concentrations of MRP8/MRP14 in serum correlated well with those in synovial fluid (r = 0.78) and showed a strong correlation with disease activity (r = 0.62). After intraarticular triamcinolone therapy, the serum concentrations of MRP8/MRP14 decreased significantly in therapy responders, whereas no differences were found in patients who showed no clinical benefit. CONCLUSION: MRP8 and MRP14 are specifically released during the interaction of monocytes with inflammatory activated endothelium, probably at sites of local inflammation. Their serum concentrations represent a useful marker for monitoring local inflammation in JRA. (+info)

... /A8 (synonyma: Calgranulin A/B; Calprotectin) are also regarded as marker proteins for a number of inflammatory diseases ... S100 calcium-binding protein A9 (S100A9) also known as migration inhibitory factor-related protein 14 (MRP14) or calgranulin B ... S100A9 (myeloid-related protein 14, MRP 14 or calgranulin B) has been implicated in the abnormal differentiation of myeloid ... Outside of malignancy, S100A9 in association with its dimerization partner, S100A8 (MRP8 or calgranulin A) signals for ...

https://en.wikipedia.org/wiki/S100A9

Calgranulin Brophy MB, Nolan EM (March 2015). "Manganese and microbial pathogenesis: sequestration by the Mammalian immune ...

https://en.wikipedia.org/wiki/Faecal_calprotectin

Human S100A12, also known as calgranulin C, was first described in 1995. The protein encoded by this gene is a member of the ... Wicki R, Marenholz I, Mischke D, Schäfer BW, Heizmann CW (December 1996). "Characterization of the human S100A12 (calgranulin C ... August 1996). "Amino acid sequence determination of human S100A12 (P6, calgranulin C, CGRP, CAAF1) by tandem mass spectrometry ... June 1999). "RAGE mediates a novel proinflammatory axis: a central cell surface receptor for S100/calgranulin polypeptides". ...

https://en.wikipedia.org/wiki/S100A12

Wicki R, Marenholz I, Mischke D, Schäfer BW, Heizmann CW (December 1996). "Characterization of the human S100A12 (calgranulin C ... Cecil DL, Terkeltaub R (June 2008). "Transamidation by transglutaminase 2 transforms S100A11 calgranulin into a procatabolic ...

https://en.wikipedia.org/wiki/S100A11

It is also known as calgranulin A. The proteins S100A8 and S100A9 form a heterodimer called calprotectin. The protein encoded ... identification and sequence analysis of a novel human calgranulin". Biochem. Biophys. Res. Commun. 221 (2): 454-8. doi:10.1006/ ...

https://en.wikipedia.org/wiki/S100A8

... a central cell surface receptor for S100/calgranulin polypeptides". Cell. 97 (7): 889-901. doi:10.1016/S0092-8674(00)80801-6. ...

https://en.wikipedia.org/wiki/Advanced_glycation_end-product

Other names for calprotectin include MRP8-MRP14, calgranulin A and B, cystic fibrosis antigen, L1, 60BB antigen, and 27E10 ...

https://en.wikipedia.org/wiki/Calprotectin

Wicki R, Marenholz I, Mischke D, Schäfer BW, Heizmann CW (Dec 1996). "Characterization of the human S100A12 (calgranulin C, p6 ...

https://en.wikipedia.org/wiki/S100A13

S100A1, S100A2, S100A3, S100A4, S100A5, S100A6, S100A7 (psoriasin), S100A8 (calgranulin A), S100A9 (calgranulin B), S100A10, ... S100A11, S100A12 (calgranulin C), S100A13, S100A14, S100A15 (koebnerisin), S100A16 S100B S100P S100Z (S100Z), CRNN; FLG, FLG2, ...

https://en.wikipedia.org/wiki/S100_protein

Other endogenous inhibitors include calgranulin (an S-100 calcium binding protein), Tamm-Horsfall protein, glycosaminoglycans, ... Considering its extremely high levels of inhibition of growth and aggregation of calcium oxalate crystals, calgranulin might be ... some researchers have found that calgranulin, a protein formed in the kidney, is a potent inhibitor of the in vivo formation of ...

https://en.wikipedia.org/wiki/Kidney_stones

... calgranulin a MeSH D12.776.157.125.750.500.200 - calgranulin b MeSH D12.776.157.125.825.249 - synaptotagmin i MeSH D12.776. ...

https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D12.776.157)

Other endogenous inhibitors include calgranulin (an S-100 calcium-binding protein), Tamm-Horsfall protein, glycosaminoglycans, ...

https://en.wikipedia.org/wiki/Kidney_stone_disease

... calgranulin a MeSH D23.050.301.562.200 - calgranulin b MeSH D23.050.301.593 - lymphocyte antigen 96 MeSH D23.050.301.625 - ...

https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D23)

... calgranulin a MeSH D12.776.641.655.500.200 - calgranulin b The list continues at List of MeSH codes (D12.776.660).. ...

https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D12.776.641)

S100A8 (calgranulin A) S100A9 (calgranulin B) S100A12 (calgranulin C) Some in vitro evidence suggests that calgranulin can ... Calgranulin+A at the US National Library of Medicine Medical Subject Headings (MeSH) Calgranulin+B at the US National Library ... Calgranulin is an S100 calcium-binding protein that is expressed in multiple cell types, including renal epithelial cells and ... Measurement of faecal calprotectin Pillay S, Asplin J, Coe F (1 August 1998). "Evidence that calgranulin is produced by kidney ...

https://en.wikipedia.org/wiki/Calgranulin

Ankylosing spondylitis: A version of the HLA-B gene called HLA-B27 increases the risk of developing ankylosing spondylitis. It is uncertain how HLA-B27 causes this increased risk. Researchers speculate that HLA-B27 may abnormally display to the immune system peptides that trigger arthritis. Other research suggests that joint inflammation characteristic of this disorder may result from improper folding of the HLA-B27 protein or the presence of abnormal forms of the protein on the cell surface. Although most patients with ankylosing spondylitis have the HLA-B27 variation, many people with this particular variation never develop the disorder. Other genetic and environmental factors are likely to affect the chances of developing ankylosing spondylitis and influence its progression. HLA-B27 is associated with the spondyloarthropathies, a group of disorders that includes ankylosing spondylitis and other inflammatory joint diseases. Some of these diseases are associated with a common skin condition ...

https://en.wikipedia.org/wiki/HLA-B

The human leukocyte antigen (HLA) system or complex is a gene complex encoding the major histocompatibility complex (MHC) proteins in humans. These cell-surface proteins are responsible for the regulation of the immune system in humans. The HLA gene complex resides on a 3 Mbp stretch within chromosome 6p21. HLA genes are highly polymorphic, which means that they have many different alleles, allowing them to fine-tune the adaptive immune system. The proteins encoded by certain genes are also known as antigens, as a result of their historic discovery as factors in organ transplants. Different classes have different functions:. HLAs corresponding to MHC class I (A, B, and C) present peptides from inside the cell. For example, if the cell is infected by a virus, the HLA system brings fragments of the virus to the surface of the cell so that the cell can be destroyed by the immune system. These peptides are produced from digested proteins that are broken down in the proteasomes. In general, these ...

https://en.wikipedia.org/wiki/Human_leucocyte_antigen

GAP43, is a nervous tissue-specific cytoplasmic protein that can be attached to the membrane via a dual palmitoylation sequence on cysteines 3 and 4. This sequence targets GAP43 to lipid rafts. It is a major protein kinase C (PKC) substrate and is considered to play a key role in neurite formation, regeneration, and plasticity.[7][8] The role of GAP-43 in CNS development is not limited to effects on axons: It is also a component of the centrosome, and differentiating neurons that do not express GAP-43 show mislocalization of the centrosome and mitotic spindles, particularly in neurogenic cell divisions. As a consequence, in the cerebellum, the neuronal precursor pool fails to expand normally and the cerebellum is significantly smaller.. Several different laboratories studying the same protein, now called GAP43, initially used different names. It was designated F1, then B-50, then GAP43, pp46, and finally neuromodulin, each name reflecting a different function of the same molecule.[9] F1 was ...

https://en.wikipedia.org/wiki/GAP-43

The beta chain is approximately 26-28 kDa. It is encoded by 6 exons, exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation.[5] ...

https://en.wikipedia.org/wiki/HLA-DRB5

... prevents or reduces neuronal degeneration in animal models of neurodegenerative diseases and these encouraging results in animals have led to several clinical trials in humans.[25] NGF promotes peripheral nerve regeneration in rats.[26] The expression of NGF is increased in inflammatory diseases where it suppresses inflammation.[27] NGF appears to promote myelin repair.[28] Hence NGF may be useful for the treatment of multiple sclerosis.[29] NGF could also be involved in various psychiatric disorders, such as dementia, depression, schizophrenia, autism, Rett syndrome, anorexia nervosa, and bulimia nervosa.[30] Dysregulation of NGF signaling has also been linked to Alzheimer's disease.[31][32][33][34][35][36] Connective tissue cells genetically engineered to synthesize and secrete NGF and implanted in patients' basal forebrains reliably pumped out NGF, which enhanced the cells' size and their ability to sprout new neural fibers. The treatment also rescued vulnerable cells, ...

https://en.wikipedia.org/wiki/Nerve_growth_factor

The peptide translocation from the cytosol into the lumen of the ER is accomplished by the transporter associated with antigen processing (TAP). TAP is a member of the ABC transporter family and is a heterodimeric multimembrane-spanning polypeptide consisting of TAP1 and TAP2. The two subunits form a peptide binding site and two ATP binding sites that face the cytosol. TAP binds peptides on the cytoplasmic side and translocates them under ATP consumption into the lumen of the ER. The MHC class I molecule is then, in turn, loaded with peptides in the lumen of the ER. The peptide-loading process involves several other molecules that form a large multimeric complex called the Peptide loading complex[7] consisting of TAP, tapasin, calreticulin, calnexin, and Erp57 (PDIA3). Calnexin acts to stabilize the class I MHC α chains prior to β2m binding. Following complete assembly of the MHC molecule, calnexin dissociates. The MHC molecule lacking a bound peptide is inherently unstable and requires the ...

https://en.wikipedia.org/wiki/MHC_class_I

https://en.wikipedia.org/wiki/Calgranulin

... calgranulin-B explanation free. What is calgranulin-B? Meaning of calgranulin-B medical term. What does calgranulin-B mean? ... Looking for online definition of calgranulin-B in the Medical Dictionary? ... Calgranulin-B , definition of calgranulin-B by Medical dictionary https://medical-dictionary.thefreedictionary.com/calgranulin- ... redirected from calgranulin-B) S100A9. A gene on chromosome 1q21 that encodes a member of the S100 family of proteins, which ...

https://medical-dictionary.thefreedictionary.com/calgranulin-B

S100/calgranulin polypeptides are present at sites of inflammation, likely released by inflammatory cells targeted to such loci ... RAGE mediates a novel proinflammatory axis: a central cell surface receptor for S100/calgranulin polypeptides Cell. 1999 Jun 25 ... S100/calgranulin polypeptides are present at sites of inflammation, likely released by inflammatory cells targeted to such loci ... and related members of the S100/calgranulin superfamily. Interaction of EN-RAGEs with cellular RAGE on endothelium, mononuclear ...

https://pubmed.ncbi.nlm.nih.gov/10399917/?dopt=Abstract

RATIONALE: Measuring levels of calgranulin A and calgranulin B in the blood of patients with breast cancer in the laboratory ... PURPOSE: This laboratory study is measuring calgranulin A and calgranulin B levels in the blood of patients with newly ... Blood draw following diagnosis of breast cancer to assess levels of circulating tumor markers, calgranulin A and calgranulin B. ... Correlation between circulating levels of calgranulin A and calgranulin B and the presence of estrogen receptor negative breast ...

https://clinicaltrials.gov/ct2/show/record/NCT00900133

The calgranulin A/B heterodimer is known as LEUKOCYTE L1 ANTIGEN COMPLEX. Calgranulin B is expressed at high concentrations in ... or heterocomplexes with CALGRANULIN A and a variety of other proteins. ... GRANULOCYTES during early monocyte differentiation, and serum calgranulin B levels are elevated in many inflammatory disorders ... Cellular Distribution and Gene Expression Pattern of Metastasin (S100A4), Calgranulin A (S100A8), and Calgranulin B (S100A9) in ...

https://www.semanticscholar.org/topic/Calgranulin-B/2982050

Background of S100A9 / Calgranulin-B / MRP14 antibody. The calcium-binding, migration inhibitory factor-related proteins, MRP-8 ... Human tonsil Frozen section stained with Biotin conjugated S100A9 / Calgranulin-B / MRP14 Antibody Cat.-No BM4026B. *BM4026B ... Alternative names for S100A9 / Calgranulin-B / MRP14 antibody. S100-A9, CAGB, MRP-14, S100 calcium-binding protein A9, ...

https://www.acris-antibodies.com/target/s100a9-antibody-calgranulin-b-antibody-mrp14-antibody.htm

Calgranulin A is a strong marker for muscle-invasive or advanced BC and recent studies have shown its potential for identifying ... Calgranulin A is a strong marker for muscle-invasive or advanced BC and recent studies have shown its potential for identifying ... Calgranulin A expression is significantly different between pTa and pT1 tumors (p = 0.000, Mann-Whitney U test) and between ... Calgranulin A (S100A8) Immunostaining: A Future Candidate for Risk Assessment in Patients with Non-Muscle-Invasive Bladder ...

https://www.urotoday.com/recent-abstracts/urologic-oncology/bladder-cancer/107014-calgranulin-a-s100a8-immunostaining-a-future-candidate-for-risk-assessment-in-patients-with-non-muscle-invasive-bladder-cancer-nmibc.html

S100/Calgranulin-Mediated Inflammation Accelerates Left Ventricular Hypertrophy and Aortic Valve Sclerosis in Chronic Kidney ... S100/Calgranulin-Mediated Inflammation Accelerates Left Ventricular Hypertrophy and Aortic Valve Sclerosis in Chronic Kidney ... S100/Calgranulin-Mediated Inflammation Accelerates Left Ventricular Hypertrophy and Aortic Valve Sclerosis in Chronic Kidney ... S100/Calgranulin-Mediated Inflammation Accelerates Left Ventricular Hypertrophy and Aortic Valve Sclerosis in Chronic Kidney ...

http://atvb.ahajournals.org/content/early/2014/05/22/ATVBAHA.114.303508

Additionally, in response to infection, the neutrophil protein calgranulin C (S100A12) was found to be increased in the feces ... Additionally, in response to infection, the neutrophil protein calgranulin C (S100A12) was found to be increased in the feces ... Shank, Janette Marie, "The Roles of Calprotectin and Calgranulin C in Campylobacter jejuni Infection. " Masters Thesis, ...

https://trace.tennessee.edu/utk_gradthes/5001/

Predicting inflammatory bowel disease in children with abdominal pain and diarrhoea: calgranulin-C versus calprotectin stool ... Predicting inflammatory bowel disease in children with abdominal pain and diarrhoea: calgranulin-C versus calprotectin stool ...

https://adc.bmj.com/content/103/6/565.altmetrics

S100A12 (EN-RAGE, calgranulin) is a member of the S100 protein family, which, in humans, consists of twenty five EF-hand (alpha ... You are here: Home Products by Molecule of Interest S100A12 (S100 calcium-binding protein A12, Calgranulin-C, CAGC, CGRP, ... References to S100A12 (S100 calcium-binding protein A12, Calgranulin-C, CAGC, CGRP, Neutrophil S100 protein, Calcium-binding ... S100A12 (S100 calcium-binding protein A12, Calgranulin-C, CAGC, CGRP, Neutrophil S100 protein, Calcium-binding protein in ...

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ELISA Calgranulin-B,Migration inhibitory factor-related protein 14,MRP14,MRP-14,Oryctolagus cuniculus,p14,Protein S100-A9, ... ELISA Calgranulin-B,Migration inhibitory factor-related protein 14,MRP14,MRP-14,Oryctolagus cuniculus,p14,Protein S100-A9, ... Product name : ELISA Calgranulin-B,Migration inhibitory factor-related protein 14,MRP14,MRP-14,Oryctolagus cuniculus,p14, ... E1793Rb ELISA Calgranulin-B,Migration inhibitory factor-related protein 14,MRP14,MRP-14,Oryctolagus cuniculus,p14,Protein S100- ...

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Calgranulin B, Mab anti_Human; Clone CF_557, Biotin conj. \ ACL2712B for more molecular products just contact us ... Index / Accu / Calgranulin B, Mab anti_Human; Clone CF_557, Biotin conj. / Product Detail : ACL2712B Calgranulin B, Mab anti_ ... We have also other products like : Calgranulin B, Mab anti_Human; Clone CF_557, Biotin conj.. Related products : Calgranulin B ... Calgranulin B, Mab anti_Human; Clone CF_557, Biotin conj. Human samples 80 % of the research is conducted on human samples. ...

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Tandem mass spectrometry analysis identified them asmyeloperoxidase chain A (MPO-A), alpha-defensin, and calgranulin. ELISA, ... Tandem mass spectrometry analysis identified them asmyeloperoxidase chain A (MPO-A), alpha-defensin, and calgranulin. ELISA, ... Identification of myeloperoxidase, alpha-defensin and calgranulin in calcium oxalate renal stones. ... alpha-defensin and calgranulin in calcium oxalate renal stones.. Clinica Chemica Acta: International Journal of Clinical ...

https://ecommons.aku.edu/pakistan_fhs_mc_surg_urol/48/

Calgranulin-A; CAGA; CGLA; MA387; NIF. The encoded protein has an amino acid length of 93 and a mass of 10.8 kDa. CP-10 is a ...

https://www.biocompare.com/pfu/110447/soids/35041/Antibodies/CP-10

S100 Calcium Binding Protein A8/Calgranulin A) ELISA Kit OSCAR DIAGNOSTIC SERVICES PVT. LTD.is an India based Company in Delhi. ... Chicken S100A8 (S100 Calcium Binding Protein A8/Calgranulin A) ELISA Kit » Chicken S100A8 (S100 Calcium Binding Protein A8/ ... Calgranulin A) ELISA Kit. Chicken S100A8 (S100 Calcium Binding Protein A8/Calgranulin A) ELISA Kit. Chicken S100A8 (S100 ... Chicken S100A8 (S100 Calcium Binding Protein A8/Calgranulin A) ELISA Kit. Chicken S100A8 (S100 Calcium Binding Protein A8/ ...

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Mouse S100A8/Calgranulin A PicoKine ELISA Kit *Detection Target: Protein S100-A8 ...

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Calgranulin AB, alpha-Synuelein (P37377), beta-Synuclein (Q63754), HNP 22; Neural nuclear proteins: NeuN-1, S/G(2) nuclear ... Calgranulin AB, alpha-Synuclein (P37377), beta-Synuclein (Q63754), HNP 22; Neural nuclear proteins: NeuN-1, S/G(2) nuclear ... Calgranulin AB, alpha-Synuclein (P37377), beta-Synuclein (Q63754), HNP 22; Neural nuclear proteins: NeuN-1, S/G(2) nuclear ... Calgranulin AB, alpha-Synuclein (P37377), beta-Synuclein (Q63754), HNP 22; Neural nuclear proteins: NeuN-1, S/G(2) nuclear ...

http://www.google.ca/patents/US8492107

4. The method of any one of claims 1 to 3, wherein said method comprises the detection of M2BP, calgranulin B, CD59, profilin, ... In another particular embodiment, the methods of the invention comprise the detection of M2BP, calgranulin B, CD59, profilin, ... The discovered candidate biomarkers include calgranulin A, serum amyloid A-4 protein and related isoforms, haptoglobin-related ... Further validation of calgranulin A by ELISA (n=20 for each group, p=0.039) and tetranectin by immunoblotting (n=35 for each ...

http://www.freepatentsonline.com/y2011/0021370.html

Serum calgranulin C is a highly sensitive autoinflammation activity indicator in patients with familial periodic fevers].. [ ... To determine the possibility of using the serum proinflammatory calcium-binding protein, or calgranulin C (S100A12), to assess ...

https://phgkb.cdc.gov/PHGKB/phgHome.action?action=forward&dbsource=huge&id=132521

Calgranulin B * Chelating Agents * Enzyme Inhibitors * S100 Proteins * 1,2-bis(2-aminophenoxy)ethane N,N,N,N-tetraacetic acid ...

https://pubmed.ncbi.nlm.nih.gov/10728757/?dopt=Abstract

... or Calgranulin-B (CAGB). S100A9 is a member of the S100 family of calcium and zinc binding proteins. S100A9 is predominantly ...

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S100A8 (calgranulin A, MRP8) and S100A9 (calgranulin B, MRP14) are members of the calcium-binding protein family S100 genes (54 ... 33), the proto-oncogene Bcl-2, and two calcium-binding protein genes, S100A8 (calgranulin A, MRP8) and S100A9 (calgranulin B, ... calgranulin A, MRP8) and S100A9 (calgranulin B, MRP14), apoptosis inhibitor BIRC5 (surviving, baculoviral IAP repeat-containing ... Similarly, calgranulin expression extended from the intermediate layers to superficial cells as the CIN grade progressed (P , ...

https://cebp.aacrjournals.org/content/19/8/2003

Calgranulin B. זE C Z [ g *(A)HL-60. *(B)DMSO-treated HL-60 ...

https://www.cosmobio.co.jp/product/detail/mouse-igg-lambda-binding-protein-hrp-scb.asp?entry_id=17186

S100 calcium binding protein A9 calgranulin B. *S100 calcium-binding protein A9 ...

http://www.abcam.com/recombinant-human-s100a9-protein-ab95909.html

... some researchers have found that the molecule calgranulin is able to inhibit calcium oxalate crystal growth.[41] Calgranulin is ... Given the large amounts of calcium oxalate in the urine, and considering its potency, calgranulin could become an important ...

http://s3.amazonaws.com/brat4drdiabete/diabetes-insipidus-emedicine-treatment.html

S100A8/12, calgranulin A/B heterodimer ligand for RAGE.. Molecular and Cellular Mechanisms of Cardiovascular Disorders in ...

https://www.ncbi.nlm.nih.gov/pubmed/27230643

S100 calcium binding protein A9,calgranulin B,epidermal differentiation complex expressed in monocytes and granulocytes *S100A9 ...

https://www.genecards.org/cgi-bin/carddisp.pl?gene=S100A9

S100 calcium-binding protein A12 (calgranulin C) antibody. *S100 calcium-binding protein A12 antibody ...

https://www.abcam.com/s100a12cgrp-antibody-ab231722.html

S100A9/A8 (synonyma: Calgranulin A/B; Calprotectin) are also regarded as marker proteins for a number of inflammatory diseases ... S100 calcium-binding protein A9 (S100A9) also known as migration inhibitory factor-related protein 14 (MRP14) or calgranulin B ... S100A9 (myeloid-related protein 14, MRP 14 or calgranulin B) has been implicated in the abnormal differentiation of myeloid ... Outside of malignancy, S100A9 in association with its dimerization partner, S100A8 (MRP8 or calgranulin A) signals for ...

https://en.wikipedia.org/wiki/S100A9

S100A8 (calgranulin A) S100A9 (calgranulin B) S100A12 (calgranulin C) Some in vitro evidence suggests that calgranulin can inhibit the precipitation of calcium oxalate in a urine-like environment at calgranulin concentrations below physiological concentrations. (wikipedia.org)
Calgranulin B (S100A9/MRP14): A Key Molecule in Idiopathic Pulmonary Fibrosis? (semanticscholar.org)
Human tonsil Frozen section stained with Biotin conjugated S100A9 / Calgranulin-B / MRP14 Antibody Cat. (acris-antibodies.com)
Approach and Results- A bacterial artificial chromosome of the human S100/calgranulin gene cluster containing the genes and regulatory elements for S100A8, S100A9, and S100A12 was expressed in C57BL/6J mouse (hBAC-S100) to generate a novel humanized mouse model. (ahajournals.org)
ELISA Calgranulin-B,Migration inhibitory factor-related protein 14,MRP14,MRP-14,Oryctolagus cuniculus,p14,Protein S100-A9,Rabbit,S100 calcium-binding protein A9,S100A9 rabbit polyclonal These antibodies are very stable and can be stored up to 2 months at fridge temperature under 10C. (antibody-antibodies.com)
The 2B10 monoclonal antibody specifically binds to S100 calcium-binding protein A9 (S100A9), which is also known as Migration inhibitory factor-related protein 14 (MRP-14) or Calgranulin-B (CAGB). (fishersci.com)
S100 calcium-binding protein A9 (S100A9) also known as migration inhibitory factor-related protein 14 (MRP14) or calgranulin B is a protein that in humans is encoded by the S100A9 gene. (wikipedia.org)
S100A9 (myeloid-related protein 14, MRP 14 or calgranulin B) has been implicated in the abnormal differentiation of myeloid cells in the stroma of cancer, and to leukemia progression. (wikipedia.org)
Outside of malignancy, S100A9 in association with its dimerization partner, S100A8 (MRP8 or calgranulin A) signals for lymphocyte recruitment in sites of inflammation. (wikipedia.org)
These transgenic mice express S100a9 (S100 calcium binding protein A9 (calgranulin B)), a myeloid-related protein, and GFP under the control of the hematopoietic cell-specific H2-K promoter. (jax.org)
Human MRP14, Granulocytes, stimulated Monocytes and Macrophages: This clone identifies the Ca2+-binding 14 kDa subunit of the inflammatory L-1 protein complex, also called S100A9 or Calgranulin B. It is useful for the characterization of circulating granulocytes or inflammatory infiltrates of the myelo-monocytic lineage which express MRP14 differently depending on the inflammatory status of the disease. (antibodies-online.com)
MRP8 (Calgranulin A, 10.8 kDa) and MRP14 (Calgranulin B, 13.2 kDa) belong to the S-100 protein family (S100A8 and S100A9) and can form Ca2+ dependent homo- or hetero-complexes of various composition. (acris-antibodies.com)
Mrp exists as a heterodimer of Mrp-14 (S100A9 or calgranulin B) and Mrp-8 (S100A8 or calgranulin A), with prior studies demonstrating an important role for the Mrp complex in the inflammatory response to injury. (ahajournals.org)

This antibody identifies the Ca2+-binding light subunit of the inflammatory L-1 protein complex, also called S100A8 or Calgranulin A. It is useful for the identification of the 8 kDa subunit in various immunological techniques. (antikoerper-online.de)

Gottsch and colleagues have suggested that this disorder can result from a host response to calgranulin C, a normally hidden antigen expressed by keratinocytes in the corneal stroma. (aao.org)
Certain helminths express receptors for calgranulin C, suggesting that there may be a helminthic antigen that cross-reacts with calgranulin C [5] . (aao.org)
MRP8 (10.8 kDa) is also known as p8, L1 light chain, calgranulin A, and cystic fibrosis antigen (CFA). (biomedcentral.com)

Additionally, in response to infection, the neutrophil protein calgranulin C (S100A12) was found to be increased in the feces of both ferrets and humans infected with C. jejuni , while calprotectin (another neutrophil protein) was not. (tennessee.edu)
S100A12 (EN-RAGE, calgranulin) is a member of the S100 protein family, which, in humans, consists of twenty five EF-hand (alpha helix-loop-alpha helix), calcium-binding proteins, of which the vast majority is in homodimer, heterodimer or more complex forms. (biovendor.com)
1999) reported that RAGE is a central cell surface receptor for S100A12, which they referred to as EN-RAGE (Extracellular Newly identified RAGE-binding protein), and related members of the S100/calgranulin superfamily. (biovendor.com)
Interaction of EN-RAGE (S100A12) with cellular RAGE on endothelium, mononuclear phagocytes, and lymphocytes triggered cellular activation, with generation of key proinflammatory mediators. (biovendor.com)
S100A12, also known as extracellular newly identified RAGE or calgranulin C, is a proinflammatory protein predominantly secreted by neutrophils 12 , 13 . (jrheum.org)

The term calprotectin specifically refers to the Calgranulin A and B heterodimer that is formed by a non-covalent interaction. (intechopen.com)

S100/calgranulin polypeptides are present at sites of inflammation, likely released by inflammatory cells targeted to such loci by a range of environmental cues. (nih.gov)
These data highlight a novel paradigm in inflammation and identify roles for EN-RAGEs and RAGE in chronic cellular activation and tissue injury. (nih.gov)
Calgranulin A expression may also be important in promoting the induction of a regulatory macrophage phenotype that down-regulates inflammation and facilitates a healing response. (intechopen.com)

Interaction of EN-RAGEs with cellular RAGE on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. (nih.gov)

We report here that receptor for AGE (RAGE) is a central cell surface receptor for EN-RAGE (extracellular newly identified RAGE-binding protein) and related members of the S100/calgranulin superfamily. (nih.gov)
Excessive amounts of calgranulin A/B in extracellular compartments of tissues correlates with a variety of inflammatory disorders. (intechopen.com)
Expression and release of calgranulin A/B in the extracellular milieu can be triggered by IL-1α. (intechopen.com)
Extracellular calgranulin A/B can then bind to and activate toll like receptor 4 (TLR 4), which in turn initiates further expression of pro-inflammatory mediators such as IL-1, IL-6, and IL-8. (intechopen.com)

For example, granulocytes depend on the intracellular calgranulin A/B complex to adequately participate in cell adhesion, cytokinesis, cytokine secretion, and activation of the respiratory burst. (intechopen.com)

Using immunohistochemistry, they then validated their findings in 67 patients - of which 25 ultimately had proven appendicitis - who had gone to the emergency department at Children's Hospital Boston with possible symptoms of appendicitis: Steen and his co-researchers determined that three proteins - LRG, calgranulin A, or S100-A8, and alpha-1-acid glycoprotein - exhibited "substantial enrichment in the urine of patients with appendicitis," they said in the study. (genomeweb.com)

Patients undergo a blood draw following diagnosis of breast cancer to assess levels of circulating tumor markers, calgranulin A and calgranulin B. Serum samples are evaluated by enzyme-linked immunosorbent assay for tumor marker expression. (clinicaltrials.gov)
Serum calgranulin C is a highly sensitive autoinflammation activity indicator in patients with familial periodic fevers]. (cdc.gov)

Kaplan-Meier survival analysis and Cox regression were performed to determine whether calgranulin A expression is associated with recurrence-free survival (RFS), progression-free survival (PFS), or cancer-specific survival (CSS). (urotoday.com)
Calgranulin A remained an independent factor for RFS (p = 0.024, HR 2.43) and PFS (p = 0.002, HR 5.92) according to the multivariate Cox regression model. (urotoday.com)

RATIONALE: Measuring levels of calgranulin A and calgranulin B in the blood of patients with breast cancer in the laboratory may help doctors identify and learn more about biomarkers related to breast cancer. (clinicaltrials.gov)
3. The method of any one of claim 1 or 2, wherein at least one of said oral cancer biomarkers is selected from the group consisting of M2BP, calgranulin B, CD59, profilin, and catalase. (freepatentsonline.com)

In the urinary tract, over expression of calgranulin A is not specific for infection. (intechopen.com)

Determine circulating levels of calgranulin A and calgranulin B in patients with estrogen receptor negative or estrogen receptor positive, newly diagnosed, primary stage I-III adenocarcinoma of the breast. (clinicaltrials.gov)
Conclusions- Myeloid-derived human S100/calgranulin is associated with the development of cardiac hypertrophy and ectopic cardiac calcification in a receptor for advanced glycation end products-dependent manner in a mouse model of CKD. (ahajournals.org)

Blockade of EN-RAGE/RAGE quenches delayed-type hypersensitivity and inflammatory colitis in murine models by arresting activation of central signaling pathways and expression of inflammatory gene mediators. (nih.gov)

Shank, Janette Marie, "The Roles of Calprotectin and Calgranulin C in Campylobacter jejuni Infection. (tennessee.edu)
The interaction of these cytokines and chemokines with calgranulin A can create an autocrine / paracine mediated pro-inflammatory feedback loop that does not necessarily resolve infection. (intechopen.com)

Calgranulin A protein expression was evaluated through the immunohistochemistry of 158 randomly selected, transurethrally resected BC specimens of separate patients (pTa 89, pT1 69) using tissue microarrays. (urotoday.com)
Calgranulin A expression is significantly different between pTa and pT1 tumors (p = 0.000, Mann-Whitney U test) and between tumor grades (p = 0.015, Kruskal-Wallis test). (urotoday.com)
Calgranulin A expression in NMIBC, detected through immunohistochemistry, is a promising marker for the identification of NMIBC patients at high risk of recurrence and progression. (urotoday.com)

Calgranulin is an S100 calcium-binding protein that is expressed in multiple cell types, including renal epithelial cells and neutrophils. (wikipedia.org)
Identification of myeloperoxidase, alpha-defensin and calgranulin in calcium oxalate renal stones. (aku.edu)

Tandem mass spectrometry analysis identified them asmyeloperoxidase chain A (MPO-A), alpha-defensin, and calgranulin. (aku.edu)

In addition, calgranulin induces apoptosis in cells that stimulate the inflammatory cascade. (intechopen.com)

Identification of myeloperoxidase, alpha-defensin and calgranulin in c" by Shamim Mushtaq, Anwar Ali Siddiqui et al. (aku.edu)

We tested the hypothesis that human S100/calgranulin would accelerate cardiovascular disease in mice subjected to CKD. (ahajournals.org)

However, the role of calgranulin in the stone formation process has not been evaluated. (wikipedia.org)

Calgranulin A is a strong marker for muscle-invasive or advanced BC and recent studies have shown its potential for identifying patients at risk even in non-muscle-invasive bladder cancer (NMIBC). (urotoday.com)

Blood draw following diagnosis of breast cancer to assess levels of circulating tumor markers, calgranulin A and calgranulin B. (clinicaltrials.gov)

Calgranulin A/B can down-regulate immune responses through inhibition of immunoglobulin production by lymphocytes and induction of myeloid derived suppressor cells. (intechopen.com)
Calgranulin is expressed in macrophages and epithelial cells. (scbt.com)

Anti-CP-10 Antibody Products | Biocompare.com (biocompare.com)

S100A9 Rat anti-Mouse, Alexa Fluor 647, Clone: 2B10, BD 25μg; Alexa
| Fisher Scientific — S100A9 Rat anti-Mouse, Alexa Fluor 647, Clone: 2B10, BD 25μg; Alexa | Fisher Scientific (fishersci.com)

E XIgG Ɍ ^ p N | E F X ^ u b e B O ɂ ?? R ̂̑?? i | R X E o C I ?? (cosmobio.co.jp)

S100A9 Gene - GeneCards | S10A9 Protein | S10A9 Antibody (genecards.org)

Multidimensional analyses reveal modulation of adaptive and innate immune subsets by tuberculosis vaccines | Communications... (nature.com)

Protein S100-A9 - DrugBank (drugbank.ca)

Characterization of the global profile of genes expressed in cervical epithelium by Serial Analysis of Gene Expression (SAGE) |... (bmcgenomics.biomedcentral.com)

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A null mutation in the inflammation-associated S100 protein S100A8 causes early resorption of the mouse embryo. (1/326)

S100A12 is expressed exclusively by granulocytes and acts independently from MRP8 and MRP14. (2/326)

S100A8: emerging functions and regulation. (3/326)

Calcium-induced noncovalently linked tetramers of MRP8 and MRP14 detected by ultraviolet matrix-assisted laser desorption/ionization mass spectrometry. (4/326)

The two calcium-binding proteins, S100A8 and S100A9, are involved in the metabolism of arachidonic acid in human neutrophils. (5/326)

Zinc binding reverses the calcium-induced arachidonic acid-binding capacity of the S100A8/A9 protein complex. (6/326)

Biochemical characterization of the murine S100A9 (MRP14) protein suggests that it is functionally equivalent to its human counterpart despite its low degree of sequence homology. (7/326)

Myeloid-related proteins 8 and 14 are specifically secreted during interaction of phagocytes and activated endothelium and are useful markers for monitoring disease activity in pauciarticular-onset juvenile rheumatoid arthritis. (8/326)

Calgranulin B

Calgranulin A

S100 Proteins

Leukocyte L1 Antigen Complex

Calcium-Binding Proteins

Antibodies

TNF-Related Apoptosis-Inducing Ligand

Antibody Specificity

Antibodies, Viral

Aortic Valve

Sclerosis

Hypertrophy, Left Ventricular

Heart Valve Diseases

Aortic Valve Stenosis

Glycosylation End Products, Advanced

Calcinosis

Eicosanoic Acids

Biotin

Enzyme-Linked Immunosorbent Assay

Reagent Kits, Diagnostic

Sensitivity and Specificity

Reindeer

Alphaherpesvirinae

Seroepidemiologic Studies

Bibliometrics

Patents as Topic

Trauma, Nervous System

Nerve Tissue Proteins

Biological Markers

Brain Injuries

Spinal Cord Injuries

Wounds and Injuries

Salivary Proteins and Peptides

Mouth Neoplasms

Acetogenins

Periodontal Diseases

Proteomics

Telomerase

Oncogene Proteins, Viral

Virus Integration

Molecular Sequence Data

RNA, Messenger

Base Sequence

Dyskeratosis Congenita

Escherichia coli Proteins

S100 Calcium Binding Protein beta Subunit

Recombinant Proteins

Escherichia coli

Antibodies, Monoclonal

Rabbits

Antibodies, Bacterial

A null mutation in the inflammation-associated S100 protein S100A8 causes early resorption of the mouse embryo. (1/326)

S100A12 is expressed exclusively by granulocytes and acts independently from MRP8 and MRP14. (2/326)

S100A8: emerging functions and regulation. (3/326)

Calcium-induced noncovalently linked tetramers of MRP8 and MRP14 detected by ultraviolet matrix-assisted laser desorption/ionization mass spectrometry. (4/326)

The two calcium-binding proteins, S100A8 and S100A9, are involved in the metabolism of arachidonic acid in human neutrophils. (5/326)

Zinc binding reverses the calcium-induced arachidonic acid-binding capacity of the S100A8/A9 protein complex. (6/326)

Biochemical characterization of the murine S100A9 (MRP14) protein suggests that it is functionally equivalent to its human counterpart despite its low degree of sequence homology. (7/326)

Myeloid-related proteins 8 and 14 are specifically secreted during interaction of phagocytes and activated endothelium and are useful markers for monitoring disease activity in pauciarticular-onset juvenile rheumatoid arthritis. (8/326)

Gentaur Molecular :Accu \ Calgranulin B, Mab anti Human; Clone CF 557, Biotin conj. \ ACL2712B

Assay Solution. Human S100A9 ELISA Kit

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Gentaur Molecular :Ray Biotech \ Recombinant Human Complement C1q Tumor Necrosis Factor-Related Protein 1 \ 228-10151-2

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$Gentaur Molecular :Accu \ Calgranulin B, Mab anti Human; Clone CF 557, Biotin conj. \ ACL2712B$ Gentaur Molecular :Accu \ Calgranulin B, Mab anti Human; Clone CF 557, Biotin conj. \ ACL2712B

$Gentaur Molecular :Ray Biotech \ Recombinant Human Complement C1q Tumor Necrosis Factor-Related Protein 1 \ 228-10151-2$ Gentaur Molecular :Ray Biotech \ Recombinant Human Complement C1q Tumor Necrosis Factor-Related Protein 1 \ 228-10151-2