A 13.2-kDa member of the S-100 family of calcium-binding proteins that can form homo- or heterocomplexes with CALGRANULIN A and a variety of other proteins. The calgranulin A/B heterodimer is known as LEUKOCYTE L1 ANTIGEN COMPLEX. Calgranulin B is expressed at high concentrations in GRANULOCYTES during early monocyte differentiation, and serum calgranulin B levels are elevated in many inflammatory disorders such as CYSTIC FIBROSIS.
A 10.8-kDa member of the S-100 family of calcium-binding proteins that can form homo- or heterocomplexes with CALGRANULIN B and a variety of other proteins. The calgranulin A/B heterodimer is known as LEUKOCYTE L1 ANTIGEN COMPLEX. Calgranulin A is found in many cell types including GRANULOCYTES; KERATINOCYTES; and myelomonocytes, and has been shown to act as a chemotactic substance for NEUTROPHILS. Because it is present in acute inflammation but absent in chronic inflammation, it is a useful biological marker for a number of pathological conditions.
A family of highly acidic calcium-binding proteins found in large concentration in the brain and believed to be glial in origin. They are also found in other organs in the body. They have in common the EF-hand motif (EF HAND MOTIFS) found on a number of calcium binding proteins. The name of this family derives from the property of being soluble in a 100% saturated ammonium sulfate solution.
Leukocyte L1 Antigen Complex
A member of the S-100 protein family that is present at high levels in the blood and interstitial fluid in several infectious, inflammatory, and malignant disorders, including rheumatoid arthritis, inflammatory bowel disease, and cystic fibrosis. It is a complex of a light chain (CALGRANULIN A) and a heavy chain (CALGRANULIN B). L1 binds calcium through an EF-hand motif, and has been shown to possess antimicrobial activity.
A null mutation in the inflammation-associated S100 protein S100A8 causes early resorption of the mouse embryo. (1/326)S100A8 (also known as CP10 or MRP8) was the first member of the S100 family of calcium-binding proteins shown to be chemotactic for myeloid cells. The gene is expressed together with its dimerization partner S100A9 during myelopoiesis in the fetal liver and in adult bone marrow as well as in mature granulocytes. In this paper we show that S100A8 mRNA is expressed without S100A9 mRNA between 6.5 and 8. 5 days postcoitum within fetal cells infiltrating the deciduum in the vicinity of the ectoplacental cone. Targeted disruption of the S100A8 gene caused rapid and synchronous embryo resorption by day 9. 5 of development in 100% of homozygous null embryos. Until this point there was no evidence of developmental delay in S100A8-/- embryos and decidualization was normal. The results of PCR genotyping around 7.5-8.5 days postcoitum suggest that the null embryos are infiltrated with maternal cells before overt signs of resorption. This work is the first evidence for nonredundant function of a member of the S100 gene family and implies a role in prevention of maternal rejection of the implanting embryo. The S100A8 null provides a new model for studying fetal-maternal interactions during implantation. (+info)
S100A12 is expressed exclusively by granulocytes and acts independently from MRP8 and MRP14. (2/326)Changes in cytosolic calcium concentrations regulate a wide variety of cellular processes, and calcium-binding proteins are the key molecules in signal transduction, differentiation, and cell cycle control. S100A12, a recently described member of the S100 protein family, has been shown to be coexpressed in granulocytes and monocytes together with two other S100 proteins, MRP8 (S100A8) and MRP14 (S100A9), and a functional relationship between these three S100 proteins has been suggested. Using Western blotting, calcium overlays, intracellular flow cytometry, and cytospin preparations, we demonstrate that S100A12 expression in leukocytes is specifically restricted to granulocytes and that S100A12 represents one of the major calcium-binding proteins in these cells. S100A12, MRP8, and MRP14 translocate simultaneously from the cytosol to cytoskeletal and membrane structures in a calcium-dependent manner. However, no evidence for direct protein-protein interactions of S100A12 with either MRP8 or MRP14 or the heterodimer was found by chemical cross-linking, density gradient centrifugation, mass spectrometric measurements, or yeast two hybrid detection. Thus, S100A12 acts individually during calcium-dependent signaling, independent of MRP8, MRP14, and the heterodimer MRP8/MRP14. This granulocyte-specific signal transduction pathway may offer attractive targets for therapeutic intervention with exaggerated granulocyte activity in pathological states. (+info)
S100A8: emerging functions and regulation. (3/326)The functional importance of members of the S100 Ca2+-binding protein family is becoming apparent. Murine (m)S100A8 (initially named CP-10) is a potent chemoattractant (10(-13) to 10(-11) M) for myeloid cells and the chemotactic activity of other S100s has since been reported, suggesting a new class of chemoattractants. Murine S100A8 has been associated with a number of acute and chronic inflammatory conditions including bacterial infection, atherogenesis, and cystic fibrosis. It is expressed constitutively with S100A9 in neutrophils and is regulated by inflammatory stimulants in macrophages and microvascular endothelial cells. The lack of co-expression of S100A9 with S100A8 in activated macrophages suggests distinct functions for the proteins expressed by different cell types. Glucocorticoids up-regulate induction of mS100A8 by inflammatory mediators, and its exquisite sensitivity to oxidation suggests that it may protect against oxidative tissue damage. Inactivation of the mS100A8 gene is embryonic lethal, providing the first evidence for non-redundant function of a member of the S100 gene family. S100A8 may have an immunoregulatory role by contributing to the regulation of fetal-maternal interactions. It may play a protective role and its absence may allow infiltration by maternal cells, a process eventually manifesting as resorption. This review focuses on the variety of emerging functions attributed to murine S100A8, a protein implicated in embryogenesis, growth, differentiation, and immune and inflammatory processes. (+info)
Calcium-induced noncovalently linked tetramers of MRP8 and MRP14 detected by ultraviolet matrix-assisted laser desorption/ionization mass spectrometry. (4/326)MRP8 and MRP14 are members of the S100 family of calcium-binding proteins which play an important role during calcium-induced activation of phagocytes. Both proteins form noncovalently associated complexes as a prerequisite for biological functions. The exact stoichiometric composition of these complexes, however, has not been completely clarified yet. In the present study we show for the first time by ultraviolet matrix-assisted laser desorption/ionization mass spectrometry (UV-MALDI-MS) the calcium-induced formation of noncovalently associated (MRP8/MRP14)2 tetramers. Furthermore, we could determine posttranslational modifications of MRP8 and MRP14, the stoichiometric proportion of the two known MRP14 isoforms in the complexes as well as the number of calcium ions bound to the single MRP8 and MRP14 monomers and tetramers. MRP14 showed a higher affinity for calcium than MRP8. Upon complex formation the calcium binding increased to maximal saturation of the known EF hands in the complexed forms. Calcium-induced stabilization of the MRP8/MRP14 complexes was confirmed by DSC studies. Our results extend scope and application of UV-MALDI-MS by allowing identification of noncovalent protein complexes, the identification of minor alterations of subunits in such complexes as well as the determination of bound calcium ions. (+info)
The two calcium-binding proteins, S100A8 and S100A9, are involved in the metabolism of arachidonic acid in human neutrophils. (5/326)Recently, we identified the two myeloid related protein-8 (MRP8) (S100A8) and MRP14 (S100A9) as fatty acid-binding proteins (Klempt, M., Melkonyan, H., Nacken, W., Wiesmann, D., Holtkemper, U., and Sorg, C. (1997) FEBS Lett. 408, 81-84). Here we present data that the S100A8/A9 protein complex represents the exclusive arachidonic acid-binding proteins in human neutrophils. Binding and competition studies revealed evidence that (i) fatty acid binding was dependent on the calcium concentration; (ii) fatty acid binding was specific for the protein complex formed by S100A8 and S100A9, whereas the individual components were unable to bind fatty acids; (iii) exclusively polyunsaturated fatty acids were bound by S100A8/A9, whereas saturated (palmitic acid, stearic acid) and monounsaturated fatty acids (oleic acid) as well as arachidonic acid-derived eicosanoids (15-hydroxyeicosatetraenoic acid, prostaglandin E(2), thromboxane B(2), leukotriene B(4)) were poor competitors. Stimulation of neutrophil-like HL-60 cells with phorbol 12-myristate 13-acetate led to the secretion of S100A8/A9 protein complex, which carried the released arachidonic acid. When elevation of intracellular calcium level was induced by A23187, release of arachidonic acid occurred without secretion of S100A8/A9. In view of the unusual abundance in neutrophilic cytosol (approximately 40% of cytosolic protein) our findings assign an important role for S100A8/A9 as mediator between calcium signaling and arachidonic acid effects. Further investigations have to explore the exact function of the S100A8/A9-arachidonic acid complex both inside and outside of neutrophils. (+info)
Zinc binding reverses the calcium-induced arachidonic acid-binding capacity of the S100A8/A9 protein complex. (6/326)Analysis of the calcium-induced arachidonic acid (AA) binding to S100A8/A9 revealed that maximal AA binding was achieved at molar ratios of 1 mol S100A8 and 1 mol S100A9 and for values greater than 3 calciums per EF-hand. The AA binding capacity was not induced by the binding of other bivalent cations, such as Zn2+, Cu2+, and Mg2+, to the protein complex. In contrast, the binding of AA was prevented by the addition of either Zn2+ or Cu2+ in the presence of calcium, whereas Mg2+ failed to abrogate the AA binding capacity. The inhibitory effect was not due to blocking the formation of S100A8/A9 as demonstrated by a protein-protein interaction assay. Fluorescence measurements gave evidence that both Zn2+ and Cu2+ induce different conformational changes thereby affecting the calcium-induced formation of the AA binding pocket within the protein complex. Due to the fact that the inhibitory effect of Zn2+ was present at physiological serum concentrations, it is assumed that released S100A8/A9 may carry AA at inflammatory lesions, but not within the blood compartment. (+info)
Biochemical characterization of the murine S100A9 (MRP14) protein suggests that it is functionally equivalent to its human counterpart despite its low degree of sequence homology. (7/326)Due to the low degree of sequence similarity it has been speculated that murine and human S100A9 (MRP14), an inflammatory marker protein belonging to the S100 protein family, may have different cellular functions in mouse and man. The present study was undertaken to investigate the murine S100A9 protein (mS100A9) biochemically. We demonstrate that in murine peripheral CD11b+ cells up to 20% of the protein of the cytosolic fraction consists of mS100A9 and that several minor mS100A9 isoforms are present. Cell fractionation experiments with CD11b+ murine leukocytes showed that mS100A9 is found in the cytosol as well as in the insoluble fraction. Transient expression of a green fluorescence protein-mS100A9 fusion in mammalian cells revealed that mS100A9 is localized in neither the nucleus nor the vesicles. Recombinantly expressed murine S100A9 interacts in vitro with murine and human S100A8 in an in vitro glutathione S-transferase pull-down assay. Homodimerization was not observed. For further biochemical analysis the myeloid 32D cell line is presented as a suitable model, to study murine myeloid expressed S100 proteins. Both murine S100A9 and its dimerization partner mS100A8 are expressed at the onset of granulocyte-colony stimulating factor induced myeloid differentiation. Substantial amounts of this complex are constitutively secreted by granulocytic 32D cells into the medium. In summary, these data suggest, that the human and murine S100A9 may share a higher degree of functional homology than of sequence similarity. (+info)
Myeloid-related proteins 8 and 14 are specifically secreted during interaction of phagocytes and activated endothelium and are useful markers for monitoring disease activity in pauciarticular-onset juvenile rheumatoid arthritis. (8/326)OBJECTIVE: To analyze which physiologic stimuli induce secretion of myeloid-related protein 8 (MRP8) and MRP14, two S100 proteins expressed in neutrophils and monocytes, and to determine whether serum concentrations of these proteins are reliable parameters for monitoring inflammatory activity in pauciarticular juvenile rheumatoid arthritis (JRA). METHODS: Secretion of MRP8 and MRP14 was analyzed using a coculture system of endothelial cells and monocytes. Concentrations of MRP8/MRP14 in the serum and synovial fluid of JRA patients or culture medium were determined by enzyme-linked immunosorbent assay. The expression of MRP8 and MRP14 by leukocytes in synovial tissue or fluid was investigated using immunohistochemistry. RESULTS: MRP8 and MRP14 were specifically released during interaction of activated monocytes with tumor necrosis factor-stimulated endothelial cells. Secretion was mediated via an increase in intracellular calcium levels in monocytes. In contrast, contact with resting endothelium inhibited protein kinase C-induced secretion of the proteins by monocytes. In JRA patients, MRP8 and MRP14 were strongly expressed in infiltrating neutrophils and monocytes within the inflamed joints and could be found in significantly higher concentrations in synovial fluid (mean 42,800 ng/ml) compared with serum (2,060 ng/ml). Concentrations of MRP8/MRP14 in serum correlated well with those in synovial fluid (r = 0.78) and showed a strong correlation with disease activity (r = 0.62). After intraarticular triamcinolone therapy, the serum concentrations of MRP8/MRP14 decreased significantly in therapy responders, whereas no differences were found in patients who showed no clinical benefit. CONCLUSION: MRP8 and MRP14 are specifically released during the interaction of monocytes with inflammatory activated endothelium, probably at sites of local inflammation. Their serum concentrations represent a useful marker for monitoring local inflammation in JRA. (+info)
Gentaur Molecular :Accu \ Calgranulin B, Mab anti Human; Clone CF 557, Biotin conj. \ ACL2712B
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Assay Solution. Human S100A9 ELISA Kit
CAGBMigration inhibitory factor-related protein 14; Calgranulin B; calgranulin-B; Calprotectin L1H subunit; CFAGMRP-14,60B8AG; CGLB; L1AG; LIAG; MAC387; MIF; MRP-14; MRP14Leukocyte L1 complex heavy chain; NIF; P14; protein S100-A9; S100 calcium binding protein A9 (calgranulin B); S100 calcium binding protein A9; S100 calcium-binding protein A9 (calgranulin B); S100 calcium-binding protein A9; S100A9 ...
S100A9 - Wikipedia
S100 calcium-binding protein A9 (S100A9) also known as migration inhibitory factor-related protein 14 (MRP14) or calgranulin B is a protein that in humans is encoded by the S100A9 gene. The proteins S100A8 and S100A9 form a heterodimer called calprotectin. S100-A9 is a member of the S100 family of proteins containing 2 EF hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in the inhibition of casein kinase. MRP14 complexes with MRP-8 (S100A8), another member of the S100 family of calcium-modulated proteins; together, MRP8 and MRP14 regulate myeloid cell function by binding to Toll-like receptor 4 (TLR4) and the receptor for advanced glycation end products. Altered expression of the S100A9 protein is ...
In Vivo Targeting of Inflammation-Associated Myeloid-Related Protein 8/14 Via Gadolinium Immunonanoparticles | Arteriosclerosis...
In this work, we describe novel gadolinium containing designer nanoprobes displaying antibodies against Mrp-8/14 to target inflammation in a murine model of atherosclerosis. Molecular probes targeting atherosclerosis-associated moieties have been widely used in research settings.16-19 The challenge has been to identify suitable ligands that simultaneously provide sufficient selectivity and high levels of expression and serve in a pathophysiologic context so that ligation of the target results in neutral or even beneficial effects on the disease process. Inflammation-associated calgranulins, S100A8 (Mrp8) and S100A9 (Mrp14) are upregulated following activation in response to cell contact with activated endothelium.8,20,21 Mrp-14 forms a heterodimeric complex with Mrp-8 and is isolated almost exclusively in the dimeric form (Mrp).1,3-5 Mrp-14 is functionally homologous across species, is highly expressed in atherosclerosis, and participates in amplification of inflammation, providing a ...
JCI Insight - Myeloid-related protein-14 regulates deep vein thrombosis
Using transcriptional profiling of platelets from patients presenting with acute myocardial infarction, we identified myeloid-related protein-14 (MRP-14, also known as S100A9) as an acute myocardial infarction gene and reported that platelet MRP-14 binding to platelet CD36 regulates arterial thrombosis. However, whether MRP-14 plays a role in venous thrombosis is unknown. We subjected WT and Mrp-14-deficient (Mrp-14-/-) mice to experimental models of deep vein thrombosis (DVT) by stasis ligation or partial flow restriction (stenosis) of the inferior vena cava. Thrombus weight in response to stasis ligation or stenosis was reduced significantly in Mrp-14-/- mice compared with WT mice. The adoptive transfer of WT neutrophils or platelets, or the infusion of recombinant MRP-8/14, into Mrp-14-/- mice rescued the venous thrombosis defect in Mrp-14-/- mice, indicating that neutrophil- and platelet-derived MRP-14 directly regulate venous thrombogenesis. Stimulation of neutrophils with MRP-14 induced ...
Myeloid-Related Protein-14 Is a p38 MAPK Substrate in Human Neutrophils | The Journal of Immunology
The p38 MAPK pathway participates in a number of neutrophil functions critical to generation and regulation of the inflammatory response, including chemotaxis, adherence, respiratory burst activity, degranulation, and cytoskeletal reorganization (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12). Understanding the molecular mechanisms by which p38 MAPK participates in these responses is hindered by the limited number of targets of p38 MAPK identified to date in neutrophils. MAPKAPK2 and p47phox are the only clearly identified p38 MAPK targets in human neutrophils (1, 9, 10, 21). A previous study by Lewis et al. (45) determined that 20 of 25 ERK targets identified in a global screen were not previously known. Thus, it is likely that a number of important targets of p38 MAPK that participate in regulation of neutrophil responses remain to be identified. The goal of the present study was to apply a recently developed proteomic approach that allows simultaneous identification of multiple substrates of a single ...
S100A9 / Calgranulin-B / MRP14 antibody | acris-antibodies.com
The calcium-binding, migration inhibitory factor-related proteins, MRP-8 (S100A8) and MRP-14 (S100A9) belong to the S100 protein family. The…
S100A8 Antibody, anti-human, REAfinity™ - Recombinant antibodies - MACS Antibodies - Products - Miltenyi Biotec - Norge
Clone REA917 recognizes the calcium- and zinc-binding protein S100A8, also known as migration inhibitory factor-related protein 8 (MRP-8), calprotectin, or calgranulin-A. S100A8 is mainly expressed in myeloid cells, e.g., monocytes, macrophages, and granulocytes and upregulated in different tumors, e.g., in skin, breast, colon, pancreatic, bladder, and ovarian malignancies. S100A8 is involved in the regulation of inflammatory processes and immune response and plays a role in antimicrobial, cytostatic, and chemotactic activities.Additional information: Clone REA917 displays negligible binding to Fc receptors. - Norge
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Carboxylated Glycans Mediate Colitis through Activation of NF-κB | The Journal of Immunology
Oligosaccharides are increasingly being recognized as important mediators of signaling in innate and adaptive immune responses (59, 60, 61, 62, 63). Considerable diversity of oligosaccharide structures provides enormous potential for information display on cell surfaces and specific recognition by different lectins. Glycans that have the same structure can also have different functions depending upon the proteins and cell types that carry them. Examples are the selectin ligands that mediate both inflammation-initiated leukocyte rolling as well as physiological lymphocyte homing and recirculation. However, not all glycan structures in mammals have been proven, much less functionally characterized. We earlier identified a family of novel carboxylated glycans on endothelial cells and macrophages that mediate inflammation. Here, we show that interfering with the interaction between these glycans and their putative lectin partners using a monoclonal anti-glycan Ab prevents the pathogenic process in a ...
Complement C1q Tumor Necrosis Factor-Related Protein 1 - Immunoassays | BioVendor Research and Diagnostics Products
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ORBi: Browsing ORBi
in Clinical Chemistry (2008), 54. BACKGROUND: SELDI-TOF mass spectrometry (MS) is a high-throughput proteomic approach with potential for identifying novel forms of serum biomarkers of arthritis. METHODS: We used SELDI-TOF MS to analyze ... [more ▼]. BACKGROUND: SELDI-TOF mass spectrometry (MS) is a high-throughput proteomic approach with potential for identifying novel forms of serum biomarkers of arthritis. METHODS: We used SELDI-TOF MS to analyze serum samples from patients with various forms of inflammatory arthritis. Several protein profiles were collected on different Bio-Rad Laboratories ProteinChip arrays (CM10 and IMAC-Cu(2+)) and were evaluated statistically to select potential biomarkers. RESULTS: SELDI-TOF MS analyses identified several calgranulin proteins [S100A8 (calgranulin A), S100A9 (calgranulin B), S100A9*, and S100A12 (calgranulin C)], serum amyloid A (SAA), SAA des-Arg (SAA-R), and SAA des-Arg/des-Ser (SAA-RS) as biomarkers and confirmed the results with other techniques, ...
The role of interleukin-1 beta in the pathophysiology of Schnitzlers syndrome | Arthritis Research & Therapy | Full Text
Schnitzlers syndrome (SchS) is a disabling autoinflammatory disorder, characterized by a chronic urticarial rash, an M-protein, arthralgia, and other signs of systemic inflammation. Anti-interleukin-1 (IL-1) beta antibodies are highly effective, but the pathophysiology is still largely unknown. Here we studied the effect of in-vivo IL-1 inhibition on serum markers of inflammation and cellular immune responses. Eight patients with SchS received monthly subcutaneous (s.c.) injections with 150 mg canakinumab for six months. Blood was drawn for measurement of serum markers of inflammation (12 times per patient) and for functional and phenotypic analysis of both freshly isolated and toll-like receptor (TLR)-ligand-stimulated peripheral blood mononuclear cells (PBMCs) (five times per patient). All data were compared to results of healthy controls. IL-6 levels in serum and in lysates of freshly isolated PBMCs and serum myeloid-related protein (MRP8)/14 and S100A12 levels correlated with disease activity. In
TDGF1 gene - Genetics Home Reference - NIH
From NCBI Gene:. This gene encodes an epidermal growth factor-related protein that contains a cripto, FRL-1, and cryptic domain. The encoded protein is an extracellular, membrane-bound signaling protein that plays an essential role in embryonic development and tumor growth. Mutations in this gene are associated with forebrain defects. Pseudogenes of this gene are found on chromosomes 2, 3, 6, 8, 19 and X. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]. From UniProt: ...
PAA114Mu01 | 胎盘生长因子(PLGF)多克隆抗体 | Mus musculus (Mouse，小鼠) USCN(武汉优尔生商贸有限公司)
PAA114Mu01, Polyclonal Antibody to Placenta Growth Factor (PLGF), 胎盘生长因子(PLGF)多克隆抗体, PlGF2; PGF; PGFL; Placental Growth Factor-Like; Vascular Endothelial Growth Factor-Related Protein | 仅供体外研究使用，不用于临床诊断！请索取进口关税税单及报关单！
OriGene - HDGFRP2 (NM 032631) cDNA Clone
HDGFRP2 - HDGFRP2 (untagged)-Human hepatoma-derived growth factor-related protein 2 (HDGFRP2), transcript variant 2 available for purchase from OriGene - Your Gene Company.
Recombinant Human ABR 293 Cell Lysate ABR-9122HCL - Creative BioMart
Purified Recombinant Human ABR 293 Cell Lysate from Creative Biomart. Recombinant Human ABR 293 Cell Lysate can be used for research.
Calprotectin - BÜHLMANN
BÜHLMANN is a world leader in calprotectin and offers a range of assays as diagnostic tools to determine the inflammatory disease process.
7 ideas de ENSALADAS | comida vegetariana, ensaladas, recetas saludables
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MRP8抗体[MRP8 7C12/4]|Abcam中国|Anti-MRP8抗体[MRP8 7C12/4]
MRP8小鼠单克隆抗体[MRP8 7C12/4](ab20220)可与人样本反应并经WB, ELISA, IHC, Flow Cyt实验严格验证，被1篇文献引用。所有产品均提供质保服务，中国75%以上现货。
Thymosin β4 and β10 in Sjögrens syndrome: saliva proteomics and minor salivary glands expression | Arthritis Research &...
In SS, the proteomic analysis of saliva appears to be a very useful way to assess how the autoimmune disease affects the exocrine function of salivary glands. It is an important tool for identifying biomarkers and posttranslational modifications, as well as for identifying and quantifying peptides, proteins, and neoantigens. A number of proteins have been indicated as pSS biomarkers, showing two- to threefold up- or downregulation at significantly different levels compared with healthy subjects or having an exclusive presence in SS saliva. Proteins of acinar origin (i.e., α-amylase, carbonic anhydrase VI, proline-rich proteins, prolactin-inducible protein precursor) were reduced in patients with pSS, while inflammatory phase proteins, protease inhibitors, and antimicrobial peptides (i.e., lactoferrin, β2-microglobulin, immunoglobulin κ-light chain, calgranulin B, lipocalin 1 precursor, phosphatidylethanolamine binding protein, and defensins) were increased, compared with those in healthy ...
Myeloid Cell Function in MRP-14 (S100A9) Null Mice | Molecular and Cellular Biology
In this study, we characterized mice that were deficient in the S100 protein MRP-14 (S100A9). Although there was normal expression of MRP-8 mRNA in the MRP-14−/− myeloid cells, surprisingly, no MRP-8 protein was present. The absence of MRP-8 protein could be due to inefficient translation of MPR-8 mRNA or, more likely, due to instability of MRP-8 protein in the absence of its partner, MRP-14. This finding contrasts with evidence that murine MRP-14 and MRP-8 (CP-10) exist separately in myeloid cells (28, 40) and that CP-10 alone can function as a potent chemotactic factor (28, 29). In addition, immunohistochemical studies of mouse tissues show that MRP-14 (this study) and MRP-8 (data not shown) are coexpressed in myeloid cells. In support of this finding, the heterodimer can be isolated from spleen (data not shown) and bone marrow (13). Information from physical studies with the human proteins indicates that MRP-8 and MRP-14 form a heterodimer more readily than either forms a homodimer and ...
Our previous studies illustrated that deletion of RAGE was protective in murine models of long-term diabetes-associated neuropathy (14,15). Because RAGE is critically involved in inflammatory mechanisms by virtue of its ability to bind members of the S100/calgranulin family, HMGB1 and Mac-1 (19,20,36), we tested its role in superimposed acute nerve crush injury. These studies bear clinical relevance because diabetic subjects often sustain thermal and other acute injuries to their extremities during advancing neuropathy (7-10). This present work reveals that RAGE, particularly in bone marrow cells and in diabetes, contributes to maladaptive inflammatory mechanisms after acute nerve crush.. Our data confirmed that diabetes was associated with increased expression of AGEs in the peripheral nerve in the basal state (15) and buttressed our findings that AGE levels were lower in diabetic RAGE-null mice compared with diabetic WT mice (37). We previously showed that RAGE suppresses mRNA and protein ...
Efficacy Study of ABR-215050 to Treat Prostate Cancer - Full Text View - ClinicalTrials.gov
For asymptomatic patients with Castrate-Resistant Prostate Cancer (CRPC), a window of opportunity is present. During this window of opportunity an intervention with little or no toxicity and the potential for extending the symptom-free period would be of great value to keep metastatic patients in an asymptomatic stage and thus delay the introduction of chemotherapy. The purpose of this study is to evaluate the safety and efficacy of ABR-215050 as an interventional agent for this role.. Overall survival for patients participating in study 07TASQ08 will be evaluated retrospectively using a separate study protocol 11TASQ11. ...
Ethyl quinoline-3-carboxylate 50741-46-3 Chemical Properties Physical Properties
Ethyl quinoline-3-carboxylate chemical properties, What are the chemical properties of Ethyl quinoline-3-carboxylate 50741-46-3, What are the physical properties of Ethyl quinoline-3-carboxylate ect.
22934-41-4, Quinoline-5-carbaldehyde, CAS No 22934-41-4 Quinoline-5-carbaldehyde il
CAS NO:22934-41-4; Chemical name:Quinoline-5-carbaldehyde ; physical and chemical property of 22934-41-4, Quinoline-5-carbaldehyde is provided by ChemNet.com
Methyl quinoline-3-carboxylate - Alfa Chemistry
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QUINOLINE-2,3-DIOL | 26386-86-7 - 化学云数据库
QUINOLINE-2,3-DIOL,CCD编号:CCD00133569,分子式:C9 H7 N O2,分子量:161.159,同义词：QUINOLINE-2,3-DIOL; 2,3-QUINOLINEDIOL; 2,3-DIHYDROXYQUINOLINE; 分子结构,化学云数据库
DeCS Ingl s+escopo
A structurally diverse group of endogenous molecules that are multifunctional, having physiological functions inside the cell, but when released from dying cells or from cells under stress or certain immune cells, they function to activate INNATE IMMUNITY. Uncontrolled and excessive release of alarmins may contribute to INFLAMMATION; CARCINOGENESIS, and NEOPLASM METASTASIS. Alarmins are also critical for heart and nerve tissue homeostasis. . ...
PQR | (4ar,10ar)-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinoline-6,8-diol
You are viewing an interactive 3D depiction of the molecule (4ar,10ar)-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinoline-6,8-diol (C13H17NO2) from the PQR.
PQR | (4as,10as)-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinoline-6,8-diol
You are viewing an interactive 3D depiction of the molecule (4as,10as)-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinoline-6,8-diol (C13H17NO2) from the PQR.
2-Chloro-8,8-dimethyl-8,9-dihydro-7H-chromeno[2,3-b]quinoline-10,12-dione - GeoScience.net
Srinivasan, T.; Yuvaraj, P.; Reddy, B.S.R.; Velmurugan, D., 2013: 2-Chloro-8,8-dimethyl-8,9-dihydro-7H-chromeno[2,3-b]quinoline-10,12-dione
TY - JOUR. T1 - 10-hydroxy-及び10-aminopyridazino[4,5-b]-quinoline-1,4(2H,3H)-dionesの合成及びその化学発光. AU - Sasaki, Kenji. PY - 1999. Y1 - 1999. M3 - Article. VL - 50. SP - 43. EP - 46. JO - Default journal. JF - Default journal. ER - ...
Damage-associated molecular pattern - Wikipedia
Damage-associated molecular patterns (DAMPs), also known as danger-associated molecular patterns, danger signals, and alarmin, are host biomolecules that can initiate and perpetuate a noninfectious inflammatory response. In contrast, pathogen-associated molecular patterns (PAMPs) initiate and perpetuate the infectious pathogen-induced inflammatory response. A subset of DAMPs are nuclear or cytosolic proteins. When released outside the cell or exposed on the surface of the cell following tissue injury, they move from a reducing to an oxidizing milieu, which results in their denaturation. Also, following necrosis (a kind of cell death), tumor DNA is released outside the nucleus, and outside the cell, and becomes a DAMP. Two papers appearing in 1994 presaged the deeper understanding of innate immune reactivity, dictating the subsequent nature of the adaptive immune response. The first came from transplant surgeons who conducted a prospective randomized double-blind placebo-controlled trial. ...
4-HYDROXY-BENZO[H]QUINOLINE-3-CARBOXYLIC ACID 35957-14-3 Chemical Properties Physical Properties
4-HYDROXY-BENZO[H]QUINOLINE-3-CARBOXYLIC ACID chemical properties, What are the chemical properties of 4-HYDROXY-BENZO[H]QUINOLINE-3-CARBOXYLIC ACID 35957-14-3, What are the physical properties of 4-HYDROXY-BENZO[H]QUINOLINE-3-CARBOXYLIC ACID ect.
6-Bromo-2-(5-methylthiophen-2-yl)quinoline-4-carboxylic acid - Alfa Chemistry
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ChemIDplus - 84371-05-1 - VKRODJWIGYCXIB-UHFFFAOYSA-N - 2,7,9-Tricarboxypyrrolo(2,3-f)quinoline-4-ol-5-one - Similar structures...
84371-05-1 - VKRODJWIGYCXIB-UHFFFAOYSA-N - 2,7,9-Tricarboxypyrrolo(2,3-f)quinoline-4-ol-5-one - Similar structures search, synonyms, formulas, resource links, and other chemical information.
1,3-dimethyl-5-sulfanylpyrimido[4,5-b]quinoline-2,4(1H,3H)-dione - C13H11N3O2S, density, melting point, boiling point,...
1,3-dimethyl-5-sulfanylpyrimido[4,5-b]quinoline-2,4(1H,3H)-dione - C13H11N3O2S, synthesis, structure, density, melting point, boiling point
6-Bromo-2-(3-isobutoxyphenyl)quinoline-4-carboxylic acid - Science Exchange
6-Bromo-2-(3-isobutoxyphenyl)quinoline-4-carboxylic acid - Science Exchange Lets You Compare Quotes From Leading Service Providers.
Calprotectin | Lab Tests Online
Calprotectin is released by white blood cells (neutrophils) in the digestive tract with inflammation. Calprotectin tests measure levels in stool to help detect conditions such as inflammatory bowel disease (IBD) and infections.
Human S100A7 Induces Mature Interleukin1α Expression by RAGE-p38 MAPK-Calpain1 Pathway in Psoriasis - pdf descargar
Human S100A7 Induces Mature Interleukin1α Expression by RAGE-p38 MAPK-Calpain1 Pathway in Psoriasis. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
Recombinant Human S100 alpha 2 protein (ab104821) References
References for Abcams Recombinant Human S100 alpha 2 protein (ab104821). Please let us know if you have used this product in your publication
Recombinant Human S100A4 protein (ab85489) References
References for Abcams Recombinant Human S100A4 protein (ab85489). Please let us know if you have used this product in your publication
Quinoline-2,4-dicarboxylic acid - Elabmart.com
Relatively unreactive organic reagents should be collected in container A. If halogenated, they should be collected in container B. For solid residues use container C ...
CRP and calprotectin
Ops I meant CRP Are these different measures and tests or are they the same thing? ETA: ok I realize now that they are different. My CRP is .7 (within...
S-EPMC4626273 - Damage-associated molecular patterns generated in osteoarthritis directly excite murine nociceptive neurons...
To determine whether selected damage-associated molecular patterns (DAMPs) present in the osteoarthritic (OA) joints of mice excite nociceptors through Toll-like receptor 4 (TLR-4).The ability of S100A8 and ?2 -macroglobulin to excite nociceptors was determined by measuring the release of monocyte chemoattractant protein 1 (MCP-1) by cultured dorsal root ganglion (DRG) cells as well as by measuring the intracellular calcium concentration ([Ca(2+) ]i ) in cultured DRG neurons from naive mice or from mice that had undergone surgical destabilization of the medial meniscus (DMM) 8 weeks previously. The role of TLR-4 was assessed using TLR-4(-/-) cells or a TLR-4 inhibitor. The [Ca(2+) ]i in neurons within ex vivo intact DRGs was measured in samples from Pirt-GCaMP3 mice. Neuronal expression of the Tlr4 gene was determined by in situ hybridization. DMM surgery was performed in wild-type and TLR-4(-/-) mice; mechanical allodynia was monitored, and joint damage was assessed histologically after 16 weeks.DRG
Pathogen- or damage-associated molecular patterns during nonalcoholic fatty liver disease development<...
TY - JOUR. T1 - Pathogen- or damage-associated molecular patterns during nonalcoholic fatty liver disease development. AU - Alisi, Anna. AU - Carsetti, Rita. AU - Nobili, Valerio. PY - 2011/11. Y1 - 2011/11. UR - http://www.scopus.com/inward/record.url?scp=80055057691&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=80055057691&partnerID=8YFLogxK. U2 - 10.1002/hep.24611. DO - 10.1002/hep.24611. M3 - Article. C2 - 22045668. AN - SCOPUS:80055057691. VL - 54. SP - 1500. EP - 1502. JO - Hepatology. JF - Hepatology. SN - 0270-9139. IS - 5. ER - ...
The calcium-binding protein S100A2 interacts with p53 and modulates its transcriptional activity - Zurich Open Repository and...
Head and neck squamous cell carcinoma express high levels of the EF-hand calcium-binding protein S100A2 in contrast to other tumorigenic tissues and cell lines where the expression of this protein is reduced. Subtractive hybridization of tumorigenic versus normal tumor-derived mammary epithelial cells has previously identified the S100A2 protein as potential tumor suppressor. The biological function of S100A2 in carcinogenesis, however, has not been elucidated to date. Here, we report for the first time that during recovery from hydroxyurea treatment, the S100A2 protein translocated from the cytoplasm to the nucleus and co-localized with the tumor suppressor p53 in two different oral carcinoma cells (FADU and SCC-25). Co-immunoprecipitation experiments and electrophoretic mobility shift assay showed that the interaction between S100A2 and p53 is Ca(2+)-dependent. Preliminary characterization of this interaction indicated that the region in p53 involved with binding to S100A2 is located at the C ...
Name: 6-Bromo-3-methyl-3H-naphtho[1,2,3-de]quinoline-2,7-dione CA Name: 3H-Naphtho[1,2,3-de]quinoline-2,7-dione,6-bromo-3-methyl- Molecular Structure: 6-Bromo-3-methyl-3H-naphtho[1,2,3-de]quinoline-2,7-dione,3H-Naphtho[1,2,3-de]quinoline-2,7-dione,6-bromo-3-methyl-,CAS 81-85-6,340.17,C17H10BrNO2 6-Bromo-3-methyl-3H-naphtho[1,2,3-de]quinoline-2,7-dione,3H-Naphtho[1,2,3-de]quinoline-2,7-dione,6-bromo-3-methyl-,CAS 81-85-6,340.17,C17H10BrNO2 Molecular Formula:C17H10BrNO2 Molecular Weight: 340.17 CAS Registry Number: 81-85-6
Molecular cloning and characterization of spiggin : an androgen-regulated extraorganismal adhesive with structural similarities...
One of the most definitive examples of a vertebrate extraorganismal structural protein can be found in three-spined sticklebacks (Gasterosteus aculeatus). In the breeding male the kidney hypertrophies and synthesizes an adhesive protein called spiggin, which is secreted into the urinary bladder from where it is employed as a structural thread for nest building. This paper describes the first molecular characterization of spiggin and demonstrates that this adhesive is a protein complex assembled from a potential of three distinct subunits (alpha, beta, and gamma). These subunits arise by alternative splicing, and 11-ketoandrogens induce their expression in stickleback kidneys. Analysis of the predicted amino acid sequence of each subunit reveals a modular organization whose structural elements display a similarity to the multimerization domains found within von Willebrand Factor-related proteins. These results implicate that spiggin utilizes a conserved multimerization mechanism for the ...
ANTIBODY TO RAGE AND USES FOR IN VIVO IMAGING OR FOR TARGETING THERAPY - Patent application
0083] 1. Davies J R, Rudd J H, Weissberg P L. Molecular and metabolic imaging of atherosclerosis. J Nucl Med. 2004; 45:1898-1907.  2. Kislinger T, Fu C, Huber B, Qu W, Taguchi A, Yan S D, Hofmann M, Yan S F, Pischetsrieder M, Stern D, Schmidt A M. N.sup.ε-(carboxymethyl) lysine adducts of proteins are ligands for receptor for advanced glycation endproducts that activate cell signaling pathways and modulate gene expression. J Biol Chem. 1999; 274:31740-31749.  3. Hofmann M A, Drury S, Fu C, Qu W, Taguchi A, Lu Y, Avila C, Kambham N, Bierhaus A, Nawroth P, Neurath M F, Slattery T, Beach D, McClary J, Nagashima M, Morser J, Stern D, Schmidt A M. RAGE mediates a novel proinflammatory axis: a central cell surface receptor for S100/calgranulin polypeptides. Cell. 1999; 97:889-901.  4. Schmidt A M, Yan S D, Brett J, Mora R, Nowygrod R, Stern D. Regulation of human mononuclear phagocyte migration by cell surface binding proteins for AGE. J. Clin. Invest. 1993; 91:2155-2168.  5. ...
Calprotectin instability may lead to undertreatment in children with IBD | Archives of Disease in Childhood
Our results indicate a steady decline in calprotectin concentration in the first 6 days after stool collection in samples kept at room temperature. A similar slope was seen in stool extracts kept at room temperature, while the stability of calprotectin was preserved in samples stored in a refrigerator at 4°C. We did not test the superiority of one ELISA kit over another. For that, we would have needed to perform a multitude of tests. The decline in calprotectin concentration over time was observed regardless of the ELISA kit used, which makes inadvertently smoothening of the curve unlikely.. Literature on calprotectin stability under various preservation conditions is scarce. A Swedish group observed a decline in calprotectin when stool samples were stored at room temperature for 7 days but claimed that the concentration remained unchanged in the first 3 days after collection.4 A Spanish group claimed that calprotectin remained stable in stool extracts stored at room temperature for 4 days,5 as ...
4-Hydroxy-8-(trifluoromethyl)quinoline-3-carboxylic acid(CAS:23779-95-5),APAC Pharmaceutical, LLC
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Author: DeMichele, Angela / Journal: Cell / Subject: 3 selected - PubAg Search Results
Interactions between stromal fibroblasts and cancer cells generate signals for cancer progression, therapy resistance, and inflammatory responses. Although endogenous RNAs acting as damage-associated molecular patterns (DAMPs) for pattern recognition receptors (PRRs) may represent one such signal, these RNAs must remain unrecognized under non-pathological conditions. We show that triggering of str ...
QUINOLINE-5-CARBONYL AZIDE - 化学云数据库
QUINOLINE-5-CARBONYL AZIDE,CCD编号:CCD03496255,分子式:C10 H6 N4 O,分子量:198.184,同义词：QUINOLINE-5-CARBONYL AZIDE; 分子结构,化学云数据库
5-Piperidin-1-ylnaphtho[2,3-h]quinoline-7,12-dione | C22H18N2O2 - PubChem
5-Piperidin-1-ylnaphtho[2,3-h]quinoline-7,12-dione | C22H18N2O2 | CID 31533 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
N-(3,4-Dipropoxyphenyl)quinoline-5-carboxamide | C22H24N2O3 - PubChem
N-(3,4-Dipropoxyphenyl)quinoline-5-carboxamide | C22H24N2O3 | CID 60361137 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
quinoline-6-carbohydrazide | VWR
Learn more about quinoline-6-carbohydrazide. We enable science by offering product choice, services, process excellence and our people make it happen.
Calcium Ion Gradients Modulate the Zinc Affinity and Antibacterial Activity of Human Calprotectin
Calprotectin (CP) is an antimicrobial protein produced and released by neutrophils that inhibits the growth of pathogenic microorganisms by sequestering essential metal nutrients in the extracellular space. In this work, spectroscopic and thermodynamic metal-binding studies are presented to delineate the zinc-binding properties of CP. Unique optical absorption and EPR spectroscopic signatures for the interfacial His3Asp and His4 sites of human calprotectin are identified by using Co(II) as a spectroscopic probe. Zinc competition titrations employing chromophoric Zn(II) indicators provide a 2:1 Zn(II):CP stoichiometry, confirm that the His[subscript 3]Asp and His[subscript 4] sites of CP coordinate Zn(II), and reveal that the Zn(II) affinity of both sites is calcium-dependent. The calcium-insensitive Zn(II) competitor ZP4 affords dissociation constants of K[subscript d1] = 133 ± 58 pM and K[subscript d2] = 185 ± 219 nM for CP in the absence of Ca(II). These values decrease to K[subscript d1] ...
The neuronal pentraxin-2 pathway is an unrecognized target in human neuroblastoma, which also offers prognostic value in...
Dive into the research topics of The neuronal pentraxin-2 pathway is an unrecognized target in human neuroblastoma, which also offers prognostic value in patients. Together they form a unique fingerprint. ...
BCL2A1 Is A Survival and Immortalization Factor for Primitive Myeloid Hematopoietic Cells. | Blood | American Society of...
Abstract. We recently reported development of an acute myeloid leukemia in a rhesus macaque transplanted with autologous CD34+ cells transduced with a murine s
S100A8 (calgranulin A) S100A9 (calgranulin B) S100A12 (calgranulin C) Some in vitro evidence suggests that calgranulin can ... Calgranulin+A at the US National Library of Medicine Medical Subject Headings (MeSH) Calgranulin+B at the US National Library ... Calgranulin is an S100 calcium-binding protein that is expressed in multiple cell types, including renal epithelial cells and ... Measurement of faecal calprotectin Pillay S, Asplin J, Coe F (1 August 1998). "Evidence that calgranulin is produced by kidney ...
... /A8 (synonyma: Calgranulin A/B; Calprotectin) are also regarded as marker proteins for a number of inflammatory diseases ... S100 calcium-binding protein A9 (S100A9) also known as migration inhibitory factor-related protein 14 (MRP14) or calgranulin B ... S100A9 (myeloid-related protein 14, MRP 14 or calgranulin B) has been implicated in the abnormal differentiation of myeloid ... Outside of malignancy, S100A9 in association with its dimerization partner, S100A8 (MRP8 or calgranulin A) signals for ...
Calgranulin Brophy MB, Nolan EM (March 2015). "Manganese and microbial pathogenesis: sequestration by the Mammalian immune ...
Gottsch, J. D.; Li, Q.; Ashraf, F.; O'Brien, T. P.; Stark, W. J.; Liu, S. H. (1999-04-01). "Cytokine-Induced Calgranulin C ... Gottsch and colleagues have suggested that calgranulin C, a protein expressed in the corneal stroma, may be a possible main ...
Human S100A12, also known as calgranulin C, was first described in 1995. The protein encoded by this gene is a member of the ... Wicki R, Marenholz I, Mischke D, Schäfer BW, Heizmann CW (December 1996). "Characterization of the human S100A12 (calgranulin C ... August 1996). "Amino acid sequence determination of human S100A12 (P6, calgranulin C, CGRP, CAAF1) by tandem mass spectrometry ... June 1999). "RAGE mediates a novel proinflammatory axis: a central cell surface receptor for S100/calgranulin polypeptides". ...
Wicki R, Marenholz I, Mischke D, Schäfer BW, Heizmann CW (December 1996). "Characterization of the human S100A12 (calgranulin C ... Cecil DL, Terkeltaub R (June 2008). "Transamidation by transglutaminase 2 transforms S100A11 calgranulin into a procatabolic ...
It is also known as calgranulin A. The proteins S100A8 and S100A9 form a heterodimer called calprotectin. The protein encoded ... identification and sequence analysis of a novel human calgranulin". Biochemical and Biophysical Research Communications. 221 (2 ...
Advanced glycation end-product
... a central cell surface receptor for S100/calgranulin polypeptides". Cell. 97 (7): 889-901. doi:10.1016/S0092-8674(00)80801-6. ...
Other names for calprotectin include MRP8-MRP14, calgranulin A and B, cystic fibrosis antigen, L1, 60BB antigen, and 27E10 ...
Wicki R, Marenholz I, Mischke D, Schäfer BW, Heizmann CW (Dec 1996). "Characterization of the human S100A12 (calgranulin C, p6 ...
S100A1, S100A2, S100A3, S100A4, S100A5, S100A6, S100A7 (psoriasin), S100A8 (calgranulin A), S100A9 (calgranulin B), S100A10, ... S100A11, S100A12 (calgranulin C), S100A13, S100A14, S100A15 (koebnerisin), S100A16 S100B S100P S100Z (S100Z), CRNN; FLG, FLG2, ...
List of MeSH codes (D12.776.157)
... calgranulin a MeSH D12.722.214.171.1240.500.200 - calgranulin b MeSH D12.7126.96.36.1995.249 - synaptotagmin i MeSH D12.776. ...
Kidney stone disease
Other endogenous inhibitors include calgranulin (an S-100 calcium-binding protein), Tamm-Horsfall protein, glycosaminoglycans, ...
List of MeSH codes (D23)
... calgranulin a MeSH D23.050.301.562.200 - calgranulin b MeSH D23.050.301.593 - lymphocyte antigen 96 MeSH D23.050.301.625 - ...
List of MeSH codes (D12.776.641)
... calgranulin a MeSH D12.776.641.655.500.200 - calgranulin b The list continues at List of MeSH codes (D12.776.660). (Wikipedia ...
Calprotectin and Calgranulin C as Biomarkers of Pancreatic Tumors: Baseline Levels and Level Changes after Surgery
Because calprotectin and calgranulin C serum levels have been demonstrated to be potential biomarkers of certain cancers and ... The baseline serum levels of calprotectin and calgranulin C in patients with malignant (,span class=inline_break,,svg xmlns: ... The baseline serum levels and kinetics of calprotectin and calgranulin C during the 7-day postoperative period were evaluated ... Taken together, the results of this study suggest that calprotectin and calgranulin C serum levels are potential biomarkers for ...
Abnormal distribution of CF delta F508 allele in azoospermic men with congenital aplasia of epididymis and vas deferens
Clinical Chemistry and Laboratory Medicine (CCLM) Volume 56 Issue 1
Human tumor necrosis factor-related apoptosis-inducing ligand receptor 4 (TRAIL-R4) ELISA Kit | CSB-E04749h | Cusabio
Human S100 calcium binding protein A6/calgranulin A (S100A6) ELISA Kit , CSB-E13089h , CusabioHuman S100 calcium binding ... Human S100 calcium binding protein A6/calgranulin A (S100A6) ELISA Kit , CSB-E13089h Cusabio Elisa ... protein A6/calgranulin A (S100A6) ELISA Kit is Available at Gentaur Genprice... ...
SCOPe 2.08: Domain d1xk4c : 1xk4 C
J F Colombel's Research | CureHunter
S100A9 in inflammation - Research output - Lund University
Type X collagen levels are elevated in serum from human osteoarthritis patients and associated with biomarkers of cartilage...
Proteomics and Metabolomics in Inflammatory Bowel Disease
Salivary Biomarker Evaluation of Chronic Pancreatitis Patien... : Pancreas
Ayako Yumine - Fingerprint - Kyushu University
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Cigarette smoke and electronic cigarettes differentially activate bronchial epithelial cells | Respiratory Research | Full Text
S100A12 Rabbit anti-Human, Polyclonal, Proteintech 150 μL; Unconjugated Products | Fisher Scientific
Find Research outputs - Discovery - the University of Dundee Research Portal
Internal Medicine - Research output - Mayo Clinic
Fervenza, F. C., Appel, G. B., Barbour, S. J., Rovin, B. H., Lafayette, R. A., Aslam, N., Jefferson, J. A., Gipson, P. E., Rizk, D. V., Sedor, J. R., Simon, J. F., Mccarthy, E. T., Brenchley, P., Sethi, S., Avila-casado, C., Beanlands, H., Lieske, J. C., Philibert, D., Li, T., Thomas, L. F., & 18 othersGreen, D. F., Juncos, L. A., Beara-lasic, L., Blumenthal, S. S., Sussman, A. N., Erickson, S. B., Hladunewich, M., Canetta, P. A., Hebert, L. A., Leung, N., Radhakrishnan, J., Reich, H. N., Parikh, S. V., Gipson, D. S., Lee, D. K., Da Costa, B. R., Jüni, P. & Cattran, D. C., Jul 4 2019, In: New England Journal of Medicine. 381, 1, p. 36-46 11 p.. Research output: Contribution to journal › Article › peer-review ...
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BMC Veterinary Research | Home page
It is a complex of a light chain (CALGRANULIN A) and a heavy chain (CALGRANULIN B). L1 binds calcium through an EF-hand motif, ... It is a complex of a light chain (CALGRANULIN A) and a heavy chain (CALGRANULIN B). L1 binds calcium through an EF-hand motif, ... Calgranulin Calprotectin L1 Antigen L1 Protein, Leukocyte Leukocyte L1 Protein Migratory Inhibitory Factor Related Protein MRP ... Calgranulin. Calprotectin. L1 Antigen. L1 Protein, Leukocyte. Leukocyte L1 Protein. Migratory Inhibitory Factor Related Protein ...
bioassay - Usa-China BIO
Melanoma; Malignant Melanoma
Gene Expression Profiling Provides Insight into the Pathophysiology of Chronic Granulomatous Disease1 | The Journal of...
Visualization of Tumor-Immune Interaction - Target-Specific Imaging of S100A8/A9 Reveals Pre-Metastatic Niche Establishment.
Intestinal inflammation and compromised barrier function in idiopathic parkinsonism: scenario captured by systematic review
- Calprotectin, also known as S100A8/9, and calgranulin C, also known as S100A12, are calcium-binding proteins stored in epithelial cells and phagocytes. (hindawi.com)
Calprotectin and calgranulin6
- Because calprotectin and calgranulin C serum levels have been demonstrated to be potential biomarkers of certain cancers and complications of major surgery, the levels of both proteins were tested in the current study in patients with benign and malignant pancreatic tumors that were surgically removed. (hindawi.com)
- The baseline serum levels and kinetics of calprotectin and calgranulin C during the 7-day postoperative period were evaluated with immunoassays in 98 adult patients who underwent pancreatic surgery. (hindawi.com)
- Taken together, the results of this study suggest that calprotectin and calgranulin C serum levels are potential biomarkers for pancreatic tumors, surgical injury to the pancreatic tissue and the development of POPFs. (hindawi.com)
- The intracellular roles of calprotectin and calgranulin C are associated with calcium regulation and cell motility. (hindawi.com)
- Calprotectin and calgranulin C have antibacterial and antiparasitic activities and have been shown to play roles in skin wound healing and liver and musculoskeletal regeneration [ 1 ]. (hindawi.com)
- Calprotectin and calgranulin C have been implicated in many human diseases, such as sepsis, Still's disease, rheumatoid arthritis, and laryngeal and pancreatic cancer [ 4 - 9 ]. (hindawi.com)
- Serum calgranulin C is a highly sensitive autoinflammation activity indicator in patients with familial periodic fevers]. (cdc.gov)
- Another protein, calgranulin A (Cal A), is involved in the regulation of several cell processes, including the cell cycle and cell differentiation. (bvsalud.org)
- These spots were identified to be cyclophilin A, calgranulin B, psoriasin, beta(2)-microglobulin, calgranutin A, glyceraldehyde-3-phosphate dehydrogenase, triose phosphate isomerase (TPI), actin-related protein 2/3 complex subunit 2 (Arp2/3 complex), and cystatin B. Conclusion. (unipi.it)
- It is a complex of a light chain ( CALGRANULIN A ) and a heavy chain ( CALGRANULIN B ). L1 binds calcium through an EF-hand motif, and has been shown to possess antimicrobial activity. (bvsalud.org)
- Further, the potential binding of RAGE to canine S100/calgranulin ligands was investigated. (bvsalud.org)
- RAGE:S100/calgranulin binding was assessed by immunoassay and electrophoretic techniques. (bvsalud.org)
- To determine the possibility of using the serum proinflammatory calcium-binding protein, or calgranulin C (S100A12), to assess activity and therapeutic efficiency in patients with periodic disease (PD) and other familial periodic fevers (FPFs). (nih.gov)
- Another protein, calgranulin A (Cal A), is involved in the regulation of several cell processes, including the cell cycle and cell differentiation. (bvsalud.org)
- In fact, in normal conditions, factors like calgranulin, a protein formed in the kidney, citrate and magnesium in the urine inhibit renal stone formation. (blogspot.com)
- However, by indirect immunofluorescence, nasal polyp sections showed weak patchy calgranulin expression in some epithelial cells, and stronger, higher frequency expression when such cells were briefly cultured. (biologists.com)
- A 13.2-kDa member of the S-100 family of calcium-binding proteins that can form homo- or heterocomplexes with CALGRANULIN A and a variety of other proteins. (ouhsc.edu)
- The calgranulin A/B heterodimer is known as LEUKOCYTE L1 ANTIGEN COMPLEX. (ouhsc.edu)
- Strong calgranulin expression in granulocytes was confirmed. (biologists.com)
- In addition to myeloid cells, a restricted subset of normal stratified squamous epithelia were found to be calgranulin-positive. (biologists.com)