Enzyme-Linked Immunosorbent Assay: An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.Reagent Kits, Diagnostic: Commercially prepared reagent sets, with accessory devices, containing all of the major components and literature necessary to perform one or more designated diagnostic tests or procedures. They may be for laboratory or personal use.Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)Reindeer: A genus of deer, Rangifer, that inhabits the northern parts of Europe, Asia, and America. Caribou is the North American name; reindeer, the European. They are often domesticated and used, especially in Lapland, for drawing sleds and as a source of food. Rangifer is the only genus of the deer family in which both sexes are antlered. Most caribou inhabit arctic tundra and surrounding arboreal coniferous forests and most have seasonal shifts in migration. They are hunted extensively for their meat, skin, antlers, and other parts. (From Webster, 3d ed; Walker's Mammals of the World, 5th ed, p1397)Alphaherpesvirinae: A subfamily of HERPESVIRIDAE characterized by a short replication cycle. The genera include: SIMPLEXVIRUS; VARICELLOVIRUS; MAREK'S DISEASE-LIKE VIRUSES; and ILTOVIRUS.Seroepidemiologic Studies: EPIDEMIOLOGIC STUDIES based on the detection through serological testing of characteristic change in the serum level of specific ANTIBODIES. Latent subclinical infections and carrier states can thus be detected in addition to clinically overt cases.Bibliometrics: The use of statistical methods in the analysis of a body of literature to reveal the historical development of subject fields and patterns of authorship, publication, and use. Formerly called statistical bibliography. (from The ALA Glossary of Library and Information Science, 1983)Aortic Valve: The valve between the left ventricle and the ascending aorta which prevents backflow into the left ventricle.Sclerosis: A pathological process consisting of hardening or fibrosis of an anatomical structure, often a vessel or a nerve.Hypertrophy, Left Ventricular: Enlargement of the LEFT VENTRICLE of the heart. This increase in ventricular mass is attributed to sustained abnormal pressure or volume loads and is a contributor to cardiovascular morbidity and mortality.Heart Valve Diseases: Pathological conditions involving any of the various HEART VALVES and the associated structures (PAPILLARY MUSCLES and CHORDAE TENDINEAE).Aortic Valve Stenosis: A pathological constriction that can occur above (supravalvular stenosis), below (subvalvular stenosis), or at the AORTIC VALVE. It is characterized by restricted outflow from the LEFT VENTRICLE into the AORTA.Glycosylation End Products, Advanced: Products derived from the nonenzymatic reaction of GLUCOSE and PROTEINS in vivo that exhibit a yellow-brown pigmentation and an ability to participate in protein-protein cross-linking. These substances are involved in biological processes relating to protein turnover and it is believed that their excessive accumulation contributes to the chronic complications of DIABETES MELLITUS.Calcinosis: Pathologic deposition of calcium salts in tissues.Period Circadian Proteins: Circadian rhythm signaling proteins that influence circadian clock by interacting with other circadian regulatory proteins and transporting them into the CELL NUCLEUS.Interferon Inducers: Agents that promote the production and release of interferons. They include mitogens, lipopolysaccharides, and the synthetic polymers Poly A-U and Poly I-C. Viruses, bacteria, and protozoa have been also known to induce interferons.Cryptochromes: Flavoproteins that function as circadian rhythm signaling proteins in ANIMALS and as blue-light photoreceptors in PLANTS. They are structurally-related to DNA PHOTOLYASES and it is believed that both classes of proteins may have originated from an earlier protein that played a role in protecting primitive organisms from the cyclical exposure to UV LIGHT.FlavoproteinsPubMed: A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.Maus Elberfeld virus: A strain of ENCEPHALOMYOCARDITIS VIRUS, a species of CARDIOVIRUS, usually causing an inapparent intestinal infection in mice. A small number of mice may show signs of flaccid paralysis.Adaptor Proteins, Signal Transducing: A broad category of carrier proteins that play a role in SIGNAL TRANSDUCTION. They generally contain several modular domains, each of which having its own binding activity, and act by forming complexes with other intracellular-signaling molecules. Signal-transducing adaptor proteins lack enzyme activity, however their activity can be modulated by other signal-transducing enzymesCalgranulin B: A 13.2-kDa member of the S-100 family of calcium-binding proteins that can form homo- or heterocomplexes with CALGRANULIN A and a variety of other proteins. The calgranulin A/B heterodimer is known as LEUKOCYTE L1 ANTIGEN COMPLEX. Calgranulin B is expressed at high concentrations in GRANULOCYTES during early monocyte differentiation, and serum calgranulin B levels are elevated in many inflammatory disorders such as CYSTIC FIBROSIS.Calgranulin A: A 10.8-kDa member of the S-100 family of calcium-binding proteins that can form homo- or heterocomplexes with CALGRANULIN B and a variety of other proteins. The calgranulin A/B heterodimer is known as LEUKOCYTE L1 ANTIGEN COMPLEX. Calgranulin A is found in many cell types including GRANULOCYTES; KERATINOCYTES; and myelomonocytes, and has been shown to act as a chemotactic substance for NEUTROPHILS. Because it is present in acute inflammation but absent in chronic inflammation, it is a useful biological marker for a number of pathological conditions.Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)Myeloid Cells: The classes of BONE MARROW-derived blood cells in the monocytic series (MONOCYTES and their precursors) and granulocytic series (GRANULOCYTES and their precursors).S100 Proteins: A family of highly acidic calcium-binding proteins found in large concentration in the brain and believed to be glial in origin. They are also found in other organs in the body. They have in common the EF-hand motif (EF HAND MOTIFS) found on a number of calcium binding proteins. The name of this family derives from the property of being soluble in a 100% saturated ammonium sulfate solution.Calcium-Binding Proteins: Proteins to which calcium ions are bound. They can act as transport proteins, regulator proteins, or activator proteins. They typically contain EF HAND MOTIFS.Endotoxins: Toxins closely associated with the living cytoplasm or cell wall of certain microorganisms, which do not readily diffuse into the culture medium, but are released upon lysis of the cells.Lipopolysaccharides: Lipid-containing polysaccharides which are endotoxins and important group-specific antigens. They are often derived from the cell wall of gram-negative bacteria and induce immunoglobulin secretion. The lipopolysaccharide molecule consists of three parts: LIPID A, core polysaccharide, and O-specific chains (O ANTIGENS). When derived from Escherichia coli, lipopolysaccharides serve as polyclonal B-cell mitogens commonly used in laboratory immunology. (From Dorland, 28th ed)Drug Design: The molecular designing of drugs for specific purposes (such as DNA-binding, enzyme inhibition, anti-cancer efficacy, etc.) based on knowledge of molecular properties such as activity of functional groups, molecular geometry, and electronic structure, and also on information cataloged on analogous molecules. Drug design is generally computer-assisted molecular modeling and does not include pharmacokinetics, dosage analysis, or drug administration analysis.Sputum: Material coughed up from the lungs and expectorated via the mouth. It contains MUCUS, cellular debris, and microorganisms. It may also contain blood or pus.CyclopropanesPhosphodiesterase 4 Inhibitors: Compounds that specifically inhibit PHOSPHODIESTERASE 4.Administration, Inhalation: The administration of drugs by the respiratory route. It includes insufflation into the respiratory tract.Selective Estrogen Receptor Modulators: A structurally diverse group of compounds distinguished from ESTROGENS by their ability to bind and activate ESTROGEN RECEPTORS but act as either an agonist or antagonist depending on the tissue type and hormonal milieu. They are classified as either first generation because they demonstrate estrogen agonist properties in the ENDOMETRIUM or second generation based on their patterns of tissue specificity. (Horm Res 1997;48:155-63)Receptors, Estrogen: Cytoplasmic proteins that bind estrogens and migrate to the nucleus where they regulate DNA transcription. Evaluation of the state of estrogen receptors in breast cancer patients has become clinically important.Estrogen Receptor beta: One of the ESTROGEN RECEPTORS that has greater affinity for ISOFLAVONES than ESTROGEN RECEPTOR ALPHA does. There is great sequence homology with ER alpha in the DNA-binding domain but not in the ligand binding and hinge domains.Estrogen Receptor alpha: One of the ESTROGEN RECEPTORS that has marked affinity for ESTRADIOL. Its expression and function differs from, and in some ways opposes, ESTROGEN RECEPTOR BETA.Arthritis, Experimental: ARTHRITIS that is induced in experimental animals. Immunological methods and infectious agents can be used to develop experimental arthritis models. These methods include injections of stimulators of the immune response, such as an adjuvant (ADJUVANTS, IMMUNOLOGIC) or COLLAGEN.Raloxifene: A second generation selective estrogen receptor modulator (SERM) used to prevent osteoporosis in postmenopausal women. It has estrogen agonist effects on bone and cholesterol metabolism but behaves as a complete estrogen antagonist on mammary gland and uterine tissue.Arthritis, Rheumatoid: A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.Amaranth Dye: A sulfonic acid-based naphthylazo dye used as a coloring agent for foodstuffs and medicines and as a dye and chemical indicator. It was banned by the FDA in 1976 for use in foods, drugs, and cosmetics. (From Merck Index, 11th ed)Urology: A surgical specialty concerned with the study, diagnosis, and treatment of diseases of the urinary tract in both sexes, and the genital tract in the male. Common urological problems include urinary obstruction, URINARY INCONTINENCE, infections, and UROGENITAL NEOPLASMS.Isoelectric Focusing: Electrophoresis in which a pH gradient is established in a gel medium and proteins migrate until they reach the site (or focus) at which the pH is equal to their isoelectric point.Health ResortsRecurrence: The return of a sign, symptom, or disease after a remission.History, 20th Century: Time period from 1901 through 2000 of the common era.History, 21st Century: Time period from 2001 through 2100 of the common era.Actinomyces viscosus: A species of ACTINOMYCES found in the oral cavity of man and hamsters. It has been isolated from actinomycotic lesions in swine, cats, and dogs and has been identified as a causative agent of animal diseases.Movement: The act, process, or result of passing from one place or position to another. It differs from LOCOMOTION in that locomotion is restricted to the passing of the whole body from one place to another, while movement encompasses both locomotion but also a change of the position of the whole body or any of its parts. Movement may be used with reference to humans, vertebrate and invertebrate animals, and microorganisms. Differentiate also from MOTOR ACTIVITY, movement associated with behavior.Species Specificity: The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.Cirsium: A plant genus of the family ASTERACEAE. Members contain pectolinarin (a flavonoid glycoside).Seed Dispersal: The various physical methods which include wind, insects, animals, tension, and water, by which a plant scatters its seeds away from the parent plant.Gene Expression Profiling: The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.Gene Expression: The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.

Oxidation regulates the inflammatory properties of the murine S100 protein S100A8. (1/297)

The myeloid cell-derived calcium-binding murine protein, S100A8, is secreted to act as a chemotactic factor at picomolar concentrations, stimulating recruitment of myeloid cells to inflammatory sites. S100A8 may be exposed to oxygen metabolites, particularly hypochlorite, the major oxidant generated by activated neutrophils at inflammatory sites. Here we show that hypochlorite oxidizes the single Cys residue (Cys41) of S100A8. Electrospray mass spectrometry and SDS-polyacrylamide gel electrophoresis analysis indicated that low concentrations of hypochlorite (40 microM) converted 70-80% of S100A8 to the disulfide-linked homodimer. The mass was 20,707 Da, 92 Da more than expected, indicating additional oxidation of susceptible amino acids (possibly methionine). Phorbol 12-myristate 13-acetate activation of differentiated HL-60 granulocytic cells generated an oxidative burst that was sufficient to efficiently oxidize exogenous S100A8 within 10 min, and results implicate involvement of the myeloperoxidase system. Moreover, disulfide-linked dimer was identified in lung lavage fluid of mice with endotoxin-induced pulmonary injury. S100A8 dimer was inactive in chemotaxis and failed to recruit leukocytes in vivo. Positive chemotactic activity of recombinant Ala41S100A8 indicated that Cys41 was not essential for function and suggested that covalent dimerization may structurally modify accessibility of the chemotactic hinge domain. Disulfide-dependent dimerization may be a physiologically significant regulatory mechanism controlling S100A8-provoked leukocyte recruitment.  (+info)

Cell type and gene-specific activity of the retinoid inverse agonist AGN 193109: divergent effects from agonist at retinoic acid receptor gamma in human keratinocytes. (2/297)

Retinoids are important regulators of epithelial differentiation. AGN 193109 is a high-affinity antagonist and inverse agonist for the nuclear retinoic acid receptors (RARs). Paradoxically, both AGN 193109 and retinoid agonists inhibit the expression of the differentiation marker MRP-8 in normal human keratinocytes (NHKs). TTNPB, an RAR agonist, and AGN 193109 mutually antagonize MRP-8 inhibition at both mRNA and protein levels. We find that this antagonism, which is greatest at an AGN 193109:TTNPB ratio of about 10:1, is absent when either compound is in significant excess. The potent RARalpha-specific agonist, AGN 193836, has no effect on MRP-8 regulation. These data indicate that inverse agonists and agonists suppress MRP-8 in NHKs through RARgamma using distinct and mutually inhibitory mechanisms. The activity of AGN 193109 on MRP-8 is cell type specific. In differentiating ECE16-1 cervical cells, TTNPB inhibits while AGN 193109 induces MRP-8 mRNA levels. The effect of AGN 193109 on genes inhibited by retinoid agonists in NHKs is also selective; expression of the differentiation markers transglutaminase 1 and keratin 6 is not down-regulated by AGN 193109 whereas stromelysin-1 expression is suppressed. These results show a complex gene and cell context-specific interplay between agonist and inverse agonist for the regulation of gene expression.  (+info)

A null mutation in the inflammation-associated S100 protein S100A8 causes early resorption of the mouse embryo. (3/297)

S100A8 (also known as CP10 or MRP8) was the first member of the S100 family of calcium-binding proteins shown to be chemotactic for myeloid cells. The gene is expressed together with its dimerization partner S100A9 during myelopoiesis in the fetal liver and in adult bone marrow as well as in mature granulocytes. In this paper we show that S100A8 mRNA is expressed without S100A9 mRNA between 6.5 and 8. 5 days postcoitum within fetal cells infiltrating the deciduum in the vicinity of the ectoplacental cone. Targeted disruption of the S100A8 gene caused rapid and synchronous embryo resorption by day 9. 5 of development in 100% of homozygous null embryos. Until this point there was no evidence of developmental delay in S100A8-/- embryos and decidualization was normal. The results of PCR genotyping around 7.5-8.5 days postcoitum suggest that the null embryos are infiltrated with maternal cells before overt signs of resorption. This work is the first evidence for nonredundant function of a member of the S100 gene family and implies a role in prevention of maternal rejection of the implanting embryo. The S100A8 null provides a new model for studying fetal-maternal interactions during implantation.  (+info)

S100A12 is expressed exclusively by granulocytes and acts independently from MRP8 and MRP14. (4/297)

Changes in cytosolic calcium concentrations regulate a wide variety of cellular processes, and calcium-binding proteins are the key molecules in signal transduction, differentiation, and cell cycle control. S100A12, a recently described member of the S100 protein family, has been shown to be coexpressed in granulocytes and monocytes together with two other S100 proteins, MRP8 (S100A8) and MRP14 (S100A9), and a functional relationship between these three S100 proteins has been suggested. Using Western blotting, calcium overlays, intracellular flow cytometry, and cytospin preparations, we demonstrate that S100A12 expression in leukocytes is specifically restricted to granulocytes and that S100A12 represents one of the major calcium-binding proteins in these cells. S100A12, MRP8, and MRP14 translocate simultaneously from the cytosol to cytoskeletal and membrane structures in a calcium-dependent manner. However, no evidence for direct protein-protein interactions of S100A12 with either MRP8 or MRP14 or the heterodimer was found by chemical cross-linking, density gradient centrifugation, mass spectrometric measurements, or yeast two hybrid detection. Thus, S100A12 acts individually during calcium-dependent signaling, independent of MRP8, MRP14, and the heterodimer MRP8/MRP14. This granulocyte-specific signal transduction pathway may offer attractive targets for therapeutic intervention with exaggerated granulocyte activity in pathological states.  (+info)

S100A8: emerging functions and regulation. (5/297)

The functional importance of members of the S100 Ca2+-binding protein family is becoming apparent. Murine (m)S100A8 (initially named CP-10) is a potent chemoattractant (10(-13) to 10(-11) M) for myeloid cells and the chemotactic activity of other S100s has since been reported, suggesting a new class of chemoattractants. Murine S100A8 has been associated with a number of acute and chronic inflammatory conditions including bacterial infection, atherogenesis, and cystic fibrosis. It is expressed constitutively with S100A9 in neutrophils and is regulated by inflammatory stimulants in macrophages and microvascular endothelial cells. The lack of co-expression of S100A9 with S100A8 in activated macrophages suggests distinct functions for the proteins expressed by different cell types. Glucocorticoids up-regulate induction of mS100A8 by inflammatory mediators, and its exquisite sensitivity to oxidation suggests that it may protect against oxidative tissue damage. Inactivation of the mS100A8 gene is embryonic lethal, providing the first evidence for non-redundant function of a member of the S100 gene family. S100A8 may have an immunoregulatory role by contributing to the regulation of fetal-maternal interactions. It may play a protective role and its absence may allow infiltration by maternal cells, a process eventually manifesting as resorption. This review focuses on the variety of emerging functions attributed to murine S100A8, a protein implicated in embryogenesis, growth, differentiation, and immune and inflammatory processes.  (+info)

Calcium-induced noncovalently linked tetramers of MRP8 and MRP14 detected by ultraviolet matrix-assisted laser desorption/ionization mass spectrometry. (6/297)

MRP8 and MRP14 are members of the S100 family of calcium-binding proteins which play an important role during calcium-induced activation of phagocytes. Both proteins form noncovalently associated complexes as a prerequisite for biological functions. The exact stoichiometric composition of these complexes, however, has not been completely clarified yet. In the present study we show for the first time by ultraviolet matrix-assisted laser desorption/ionization mass spectrometry (UV-MALDI-MS) the calcium-induced formation of noncovalently associated (MRP8/MRP14)2 tetramers. Furthermore, we could determine posttranslational modifications of MRP8 and MRP14, the stoichiometric proportion of the two known MRP14 isoforms in the complexes as well as the number of calcium ions bound to the single MRP8 and MRP14 monomers and tetramers. MRP14 showed a higher affinity for calcium than MRP8. Upon complex formation the calcium binding increased to maximal saturation of the known EF hands in the complexed forms. Calcium-induced stabilization of the MRP8/MRP14 complexes was confirmed by DSC studies. Our results extend scope and application of UV-MALDI-MS by allowing identification of noncovalent protein complexes, the identification of minor alterations of subunits in such complexes as well as the determination of bound calcium ions.  (+info)

The two calcium-binding proteins, S100A8 and S100A9, are involved in the metabolism of arachidonic acid in human neutrophils. (7/297)

Recently, we identified the two myeloid related protein-8 (MRP8) (S100A8) and MRP14 (S100A9) as fatty acid-binding proteins (Klempt, M., Melkonyan, H., Nacken, W., Wiesmann, D., Holtkemper, U., and Sorg, C. (1997) FEBS Lett. 408, 81-84). Here we present data that the S100A8/A9 protein complex represents the exclusive arachidonic acid-binding proteins in human neutrophils. Binding and competition studies revealed evidence that (i) fatty acid binding was dependent on the calcium concentration; (ii) fatty acid binding was specific for the protein complex formed by S100A8 and S100A9, whereas the individual components were unable to bind fatty acids; (iii) exclusively polyunsaturated fatty acids were bound by S100A8/A9, whereas saturated (palmitic acid, stearic acid) and monounsaturated fatty acids (oleic acid) as well as arachidonic acid-derived eicosanoids (15-hydroxyeicosatetraenoic acid, prostaglandin E(2), thromboxane B(2), leukotriene B(4)) were poor competitors. Stimulation of neutrophil-like HL-60 cells with phorbol 12-myristate 13-acetate led to the secretion of S100A8/A9 protein complex, which carried the released arachidonic acid. When elevation of intracellular calcium level was induced by A23187, release of arachidonic acid occurred without secretion of S100A8/A9. In view of the unusual abundance in neutrophilic cytosol (approximately 40% of cytosolic protein) our findings assign an important role for S100A8/A9 as mediator between calcium signaling and arachidonic acid effects. Further investigations have to explore the exact function of the S100A8/A9-arachidonic acid complex both inside and outside of neutrophils.  (+info)

Zinc binding reverses the calcium-induced arachidonic acid-binding capacity of the S100A8/A9 protein complex. (8/297)

Analysis of the calcium-induced arachidonic acid (AA) binding to S100A8/A9 revealed that maximal AA binding was achieved at molar ratios of 1 mol S100A8 and 1 mol S100A9 and for values greater than 3 calciums per EF-hand. The AA binding capacity was not induced by the binding of other bivalent cations, such as Zn2+, Cu2+, and Mg2+, to the protein complex. In contrast, the binding of AA was prevented by the addition of either Zn2+ or Cu2+ in the presence of calcium, whereas Mg2+ failed to abrogate the AA binding capacity. The inhibitory effect was not due to blocking the formation of S100A8/A9 as demonstrated by a protein-protein interaction assay. Fluorescence measurements gave evidence that both Zn2+ and Cu2+ induce different conformational changes thereby affecting the calcium-induced formation of the AA binding pocket within the protein complex. Due to the fact that the inhibitory effect of Zn2+ was present at physiological serum concentrations, it is assumed that released S100A8/A9 may carry AA at inflammatory lesions, but not within the blood compartment.  (+info)

*Calgranulin

S100A8 (calgranulin A) S100A9 (calgranulin B) S100A12 (calgranulin C) Some in vitro evidence suggests that calgranulin can ... Calgranulin A at the US National Library of Medicine Medical Subject Headings (MeSH) Calgranulin B at the US National Library ... Calgranulin is an S100 calcium-binding protein that is expressed in multiple cell types, including renal epithelial cells and ... Measurement of faecal calprotectin Pillay S, Asplin J, Coe F (1 August 1998). "Evidence that calgranulin is produced by kidney ...

*Faecal calprotectin

Calgranulin Biology portal Medicine portal. ...

*S100A9

... /A8 (synonyma: Calgranulin A/B; Calprotectin) are also regarded as marker proteins for a number of inflammatory diseases ... S100 calcium-binding protein A9 (S100A9) also known as migration inhibitory factor-related protein 14 (MRP14) or calgranulin B ... S100A9 (myeloid-related protein 14, MRP 14 or calgranulin B) has been implicated in the abnormal differentiation of myeloid ... Outside of malignancy, S100A9 in association with its dimerization partner, S100A8 (MRP8 or calgranulin A) signals for ...

*S100A8

It is also known as calgranulin A. The proteins S100A8 and S100A9 form a heterodimer called calprotectin. The protein encoded ... identification and sequence analysis of a novel human calgranulin". Biochem. Biophys. Res. Commun. 221 (2): 454-8. doi:10.1006/ ...

*S100A12

It is also known as calgranulin C. The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF- ... 1996). "Amino acid sequence determination of human S100A12 (P6, calgranulin C, CGRP, CAAF1) by tandem mass spectrometry". ... 1999). "RAGE mediates a novel proinflammatory axis: a central cell surface receptor for S100/calgranulin polypeptides". Cell. ... calgranulin C, p6, CAAF1, CGRP) gene, a new member of the S100 gene cluster on chromosome 1q21". Cell Calcium. 20 (6): 459-64. ...

*Calprotectin

Other names for calprotectin include MRP8-MRP14, calgranulin A and B, cystic fibrosis antigen, L1, 60BB antigen, and 27E10 ...

*S100A11

... calgranulin C, p6, CAAF1, CGRP) gene, a new member of the S100 gene cluster on chromosome 1q21". Cell Calcium. 20 (6): 459-64. ...

*S100 protein

S100A1, S100A2, S100A3, S100A4, S100A5, S100A6, S100A7 (psoriasin), S100A8 (calgranulin A), S100A9 (calgranulin B), S100A10, ... S100A11, S100A12 (calgranulin C), S100A13, S100A14, S100A15 (koebnerisin), S100A16 S100B S100P S100Z (S100Z) CRNN; FLG; FLG2; ...

*List of MeSH codes (D12.776.157)

... calgranulin a MeSH D12.776.157.125.750.500.200 -- calgranulin b MeSH D12.776.157.125.825.249 -- synaptotagmin i MeSH D12.776. ...

*List of MeSH codes (D23)

... calgranulin a MeSH D23.050.301.562.200 --- calgranulin b MeSH D23.050.301.593 --- lymphocyte antigen 96 MeSH D23.050.301.625 ...

*List of MeSH codes (D12.776.641)

... calgranulin a MeSH D12.776.641.655.500.200 -- calgranulin b. ...
S100 calcium-binding protein A9 (S100A9) also known as migration inhibitory factor-related protein 14 (MRP14) or calgranulin B is a protein that in humans is encoded by the S100A9 gene. The proteins S100A8 and S100A9 form a heterodimer called calprotectin. S100-A9 is a member of the S100 family of proteins containing 2 EF hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in the inhibition of casein kinase. MRP14 complexes with MRP-8 (S100A8), another member of the S100 family of calcium-modulated proteins; together, MRP8 and MRP14 regulate myeloid cell function by binding to Toll-like receptor 4 (TLR4) and the receptor for advanced glycation end products. Altered expression of the S100A9 protein is ...
In this work, we describe novel gadolinium containing designer nanoprobes displaying antibodies against Mrp-8/14 to target inflammation in a murine model of atherosclerosis. Molecular probes targeting atherosclerosis-associated moieties have been widely used in research settings.16-19 The challenge has been to identify suitable ligands that simultaneously provide sufficient selectivity and high levels of expression and serve in a pathophysiologic context so that ligation of the target results in neutral or even beneficial effects on the disease process. Inflammation-associated "calgranulins," S100A8 (Mrp8) and S100A9 (Mrp14) are upregulated following activation in response to cell contact with activated endothelium.8,20,21 Mrp-14 forms a heterodimeric complex with Mrp-8 and is isolated almost exclusively in the dimeric form (Mrp).1,3-5 Mrp-14 is functionally homologous across species, is highly expressed in atherosclerosis, and participates in amplification of inflammation, providing a ...
The calcium-binding, migration inhibitory factor-related proteins, MRP-8 (S100A8) and MRP-14 (S100A9) belong to the S100 protein family. The…
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Using transcriptional profiling of platelets from patients presenting with acute myocardial infarction, we identified myeloid-related protein-14 (MRP-14, also known as S100A9) as an acute myocardial infarction gene and reported that platelet MRP-14 binding to platelet CD36 regulates arterial thrombosis. However, whether MRP-14 plays a role in venous thrombosis is unknown. We subjected WT and Mrp-14-deficient (Mrp-14-/-) mice to experimental models of deep vein thrombosis (DVT) by stasis ligation or partial flow restriction (stenosis) of the inferior vena cava. Thrombus weight in response to stasis ligation or stenosis was reduced significantly in Mrp-14-/- mice compared with WT mice. The adoptive transfer of WT neutrophils or platelets, or the infusion of recombinant MRP-8/14, into Mrp-14-/- mice rescued the venous thrombosis defect in Mrp-14-/- mice, indicating that neutrophil- and platelet-derived MRP-14 directly regulate venous thrombogenesis. Stimulation of neutrophils with MRP-14 induced ...
The p38 MAPK pathway participates in a number of neutrophil functions critical to generation and regulation of the inflammatory response, including chemotaxis, adherence, respiratory burst activity, degranulation, and cytoskeletal reorganization (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12). Understanding the molecular mechanisms by which p38 MAPK participates in these responses is hindered by the limited number of targets of p38 MAPK identified to date in neutrophils. MAPKAPK2 and p47phox are the only clearly identified p38 MAPK targets in human neutrophils (1, 9, 10, 21). A previous study by Lewis et al. (45) determined that 20 of 25 ERK targets identified in a global screen were not previously known. Thus, it is likely that a number of important targets of p38 MAPK that participate in regulation of neutrophil responses remain to be identified. The goal of the present study was to apply a recently developed proteomic approach that allows simultaneous identification of multiple substrates of a single ...
Oligosaccharides are increasingly being recognized as important mediators of signaling in innate and adaptive immune responses (59, 60, 61, 62, 63). Considerable diversity of oligosaccharide structures provides enormous potential for information display on cell surfaces and specific recognition by different lectins. Glycans that have the same structure can also have different functions depending upon the proteins and cell types that carry them. Examples are the selectin ligands that mediate both inflammation-initiated leukocyte rolling as well as physiological lymphocyte homing and recirculation. However, not all glycan structures in mammals have been proven, much less functionally characterized. We earlier identified a family of novel carboxylated glycans on endothelial cells and macrophages that mediate inflammation. Here, we show that interfering with the interaction between these glycans and their putative lectin partners using a monoclonal anti-glycan Ab prevents the pathogenic process in a ...
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From NCBI Gene:. This gene encodes an epidermal growth factor-related protein that contains a cripto, FRL-1, and cryptic domain. The encoded protein is an extracellular, membrane-bound signaling protein that plays an essential role in embryonic development and tumor growth. Mutations in this gene are associated with forebrain defects. Pseudogenes of this gene are found on chromosomes 2, 3, 6, 8, 19 and X. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]. From UniProt: ...
PAA114Mu01, Polyclonal Antibody to Placenta Growth Factor (PLGF), 胎盘生长因子(PLGF)多克隆抗体, PlGF2; PGF; PGFL; Placental Growth Factor-Like; Vascular Endothelial Growth Factor-Related Protein | 仅供体外研究使用,不用于临床诊断!请索取进口关税税单及报关单!
HDGFRP2 - HDGFRP2 (untagged)-Human hepatoma-derived growth factor-related protein 2 (HDGFRP2), transcript variant 2 available for purchase from OriGene - Your Gene Company.
MRP8小鼠单克隆抗体[MRP8 7C12/4](ab20220)可与人样本反应并经WB, ELISA, IHC, Flow Cyt实验严格验证,被1篇文献引用。所有产品均提供质保服务,中国75%以上现货。
MRP4兔多克隆抗体(ab32550)可与大鼠, 人样本反应并经WB实验严格验证,被2篇文献引用。中国75%以上现货,所有产品均提供质保服务,可通过电话、电邮或微信获得本地专属技术支持。
in Clinical Chemistry (2008), 54. BACKGROUND: SELDI-TOF mass spectrometry (MS) is a high-throughput proteomic approach with potential for identifying novel forms of serum biomarkers of arthritis. METHODS: We used SELDI-TOF MS to analyze ... [more ▼]. BACKGROUND: SELDI-TOF mass spectrometry (MS) is a high-throughput proteomic approach with potential for identifying novel forms of serum biomarkers of arthritis. METHODS: We used SELDI-TOF MS to analyze serum samples from patients with various forms of inflammatory arthritis. Several protein profiles were collected on different Bio-Rad Laboratories ProteinChip arrays (CM10 and IMAC-Cu(2+)) and were evaluated statistically to select potential biomarkers. RESULTS: SELDI-TOF MS analyses identified several calgranulin proteins [S100A8 (calgranulin A), S100A9 (calgranulin B), S100A9*, and S100A12 (calgranulin C)], serum amyloid A (SAA), SAA des-Arg (SAA-R), and SAA des-Arg/des-Ser (SAA-RS) as biomarkers and confirmed the results with other techniques, ...
Our previous studies illustrated that deletion of RAGE was protective in murine models of long-term diabetes-associated neuropathy (14,15). Because RAGE is critically involved in inflammatory mechanisms by virtue of its ability to bind members of the S100/calgranulin family, HMGB1 and Mac-1 (19,20,36), we tested its role in superimposed acute nerve crush injury. These studies bear clinical relevance because diabetic subjects often sustain thermal and other acute injuries to their extremities during advancing neuropathy (7-10). This present work reveals that RAGE, particularly in bone marrow cells and in diabetes, contributes to maladaptive inflammatory mechanisms after acute nerve crush.. Our data confirmed that diabetes was associated with increased expression of AGEs in the peripheral nerve in the basal state (15) and buttressed our findings that AGE levels were lower in diabetic RAGE-null mice compared with diabetic WT mice (37). We previously showed that RAGE suppresses mRNA and protein ...
Human S100A7 Induces Mature Interleukin1α Expression by RAGE-p38 MAPK-Calpain1 Pathway in Psoriasis. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
References for Abcams Recombinant Human S100 alpha 2 protein (ab104821). Please let us know if you have used this product in your publication
References for Abcams Recombinant Human S100A4 protein (ab85489). Please let us know if you have used this product in your publication
Ops I meant CRP Are these different measures and tests or are they the same thing? ETA: ok I realize now that they are different. My CRP is .7 (within...
BACKGROUND/OBJECTIVES: Obesity is related to a dynamic extracellular matrix (ECM) remodeling, which involves the synthesis and degradation of different proteins, such as tenascin C (TNC) in the adipose tissue (AT). Given the functional relationship between leptin and inducible nitric oxide synthase (iNOS), our aim was to analyze the impact of the absence of the iNOS gene in AT inflammation and ECM remodeling in ob/ob mice. SUBJECTS/METHODS: The expression of genes involved in inflammation and ECM remodeling was evaluated in 10-week-old male double knockout (DBKO) mice simultaneously lacking the ob and iNOS genes as well as in ob/ob mice classified into three groups [control, leptin-treated (1 mg kg -1 day -1 ) and pair-fed ...
COLLECTION OF FAECAL SAMPLES | Sampling of faecal calprotectin; general adviceIn proctitis the area of inflamed mucosa is very limited and the contact time…
0083] 1. Davies J R, Rudd J H, Weissberg P L. Molecular and metabolic imaging of atherosclerosis. J Nucl Med. 2004; 45:1898-1907. [0084] 2. Kislinger T, Fu C, Huber B, Qu W, Taguchi A, Yan S D, Hofmann M, Yan S F, Pischetsrieder M, Stern D, Schmidt A M. N.sup.ε-(carboxymethyl) lysine adducts of proteins are ligands for receptor for advanced glycation endproducts that activate cell signaling pathways and modulate gene expression. J Biol Chem. 1999; 274:31740-31749. [0085] 3. Hofmann M A, Drury S, Fu C, Qu W, Taguchi A, Lu Y, Avila C, Kambham N, Bierhaus A, Nawroth P, Neurath M F, Slattery T, Beach D, McClary J, Nagashima M, Morser J, Stern D, Schmidt A M. RAGE mediates a novel proinflammatory axis: a central cell surface receptor for S100/calgranulin polypeptides. Cell. 1999; 97:889-901. [0086] 4. Schmidt A M, Yan S D, Brett J, Mora R, Nowygrod R, Stern D. Regulation of human mononuclear phagocyte migration by cell surface binding proteins for AGE. J. Clin. Invest. 1993; 91:2155-2168. [0087] 5. ...
0175]1. Hugel B, Martinez M C, Kunzelmann C, Freyssinet J M. Membrane microparticles: two sides of the coin. Physiology (Bethesda, Md. February 2005; 20:22-27. [0176]2. Mallat Z, Benamer H, Hugel B, Benessiano J, Steg P G, Freyssinet J M, Tedgui A. Elevated levels of shed membrane microparticles with procoagulant potential in the peripheral circulating blood of patients with acute coronary syndromes. Circulation. Feb. 29 2000; 101(8):841-843. [0177]3. Nieuwland R, Berckmans R J, Rotteveel-Eijkman R C, Maquelin K N, Roozendaal K J, Jansen P G, ten Have K, Eijsman L, Hack C E, Sturk A. Cell-derived microparticles generated in patients during cardiopulmonary bypass are highly procoagulant. Circulation. Nov. 18 1997; 96(10):3534-3541. [0178]4. Tesse A, Martinez M C, Hugel B, Chalupsky K, Muller C D, Meziani F, Mitolo-Chieppa D, Freyssinet J M, Andriantsitohaina R. Upregulation of proinflammatory proteins through NF-kappaB pathway by shed membrane microparticles results in vascular hyporeactivity. ...
... is released by white blood cells (neutrophils) in the digestive tract with inflammation. Calprotectin tests measure levels in stool to help detect conditions such as inflammatory bowel disease (IBD) and infections.
Semantic Scholar extracted view of Dynamic changes in calprotectin and its correlation with traditional markers of oxidative stress in patients with acute ischemic stroke. by Antonios Chatzopoulos et al.
Kit Component:- KN203070G1, MRPS18A gRNA vector 1 in pCas-Guide vector- KN203070G2, MRPS18A gRNA vector 2 in pCas-Guide vector- KN203070D, donor…
複合型酸化的リン酸化異常(COXPD)は、ミトコンドリアの酸化的リン酸化システムの欠陥により起こる多様な症状を持つ疾患群である。リボソームタンパクの遺伝子(MRPS16 and MRPS22)の変異は、出生前に重症な小児病を引き起こすことが報告されている。また、COXPD患者のミトコンドリアの翻訳伸長因子の遺伝子(GFM1, TUFM, TSFM およびC12orf65)に変異があることも報告されている ...
Objective: To study the active involvement of S100A8 and A9 in joint inflammation and cartilage destruction during antigen-induced arthritis (AIA).. Methods: Joint inflammation and cartilage destruction was measured with 99mTc uptake and histology. The role of S100A8/A9 was investigated by inducing AIA in S100A9-/- mice, which lacks also S100A8 at protein level, or after intra-articular injection of rS100A8 in mouse kneejoints. Cartilage destruction was measured using immunolocalisation of the neoepitope VDIPEN or NITEGE. mRNA levels of MMPs and cytokines were measured using RT-PCR.. Results: Immunization of S100A9-/- mice with the antigen mBSA induced normal cellular and humoral responses, not different from WT controls. However, joint swelling measured at day 3 and 7 after AIA induction was significantly lower (36 and 70% respectively). Histologically, at day 7 AIA, cellular mass was much lower (63- 80%) and proteoglycan depletion from cartilage layers was significantly reduced (between ...
One of the most definitive examples of a vertebrate extraorganismal structural protein can be found in three-spined sticklebacks (Gasterosteus aculeatus). In the breeding male the kidney hypertrophies and synthesizes an adhesive protein called "spiggin," which is secreted into the urinary bladder from where it is employed as a structural thread for nest building. This paper describes the first molecular characterization of spiggin and demonstrates that this adhesive is a protein complex assembled from a potential of three distinct subunits (alpha, beta, and gamma). These subunits arise by alternative splicing, and 11-ketoandrogens induce their expression in stickleback kidneys. Analysis of the predicted amino acid sequence of each subunit reveals a modular organization whose structural elements display a similarity to the multimerization domains found within von Willebrand Factor-related proteins. These results implicate that spiggin utilizes a conserved multimerization mechanism for the ...
Inflammatory mediators trigger polymorphonuclear neutrophils (PMN) to produce reactive oxygen species (ROS: O2-, H2O2, ∙OH). Mediated by myeloperoxidase in PMN, HOCl is formed, detectable in a chemiluminescence (CL) assay. We have shown that the abundant cytosolic PMN protein calprotectin (S100A8/A9) similarly elicits CL in response to H2O2 in a cell-free system. Myeloperoxidase and calprotectin worked synergistically. Calprotectin-induced CL increased, whereas myeloperoxidase-triggered CL decreased with pH | 7.5. Myeloperoxidase needed NaCl for CL, calprotectin did not. 4-hydroxybenzoic acid, binding ∙OH, almost abrogated calprotectin CL, but moderately increased myeloperoxidase activity. The combination of native calprotectin, or recombinant S100A8/A9 proteins, with NaOCl markedly enhanced CL. NaOCl may be the synergistic link between myeloperoxidase and calprotectin. Surprisingly- and unexplained- at higher concentration of S100A9 the stimulation vanished, suggesting a switch from pro-oxidant to
Head and neck squamous cell carcinoma express high levels of the EF-hand calcium-binding protein S100A2 in contrast to other tumorigenic tissues and cell lines where the expression of this protein is reduced. Subtractive hybridization of tumorigenic versus normal tumor-derived mammary epithelial cells has previously identified the S100A2 protein as potential tumor suppressor. The biological function of S100A2 in carcinogenesis, however, has not been elucidated to date. Here, we report for the first time that during recovery from hydroxyurea treatment, the S100A2 protein translocated from the cytoplasm to the nucleus and co-localized with the tumor suppressor p53 in two different oral carcinoma cells (FADU and SCC-25). Co-immunoprecipitation experiments and electrophoretic mobility shift assay showed that the interaction between S100A2 and p53 is Ca(2+)-dependent. Preliminary characterization of this interaction indicated that the region in p53 involved with binding to S100A2 is located at the C ...
Results qPCR analysis showed increased expression of the alarmins S100A8/A9 and several members of the canonical Wnt signaling pathway in the CIOA model at all time points measured. In the DMM model, the expression of S100A8/A9 and Wnt16 and WISP1 was mainly increased at day 28 after induction. Kinetics of S100 and Wnt expression were comparable, as was observed in both models. This gave rise to the question if an interrelationship existed between these factors. Therefore, we overexpressed Wnt8a and Wnt16, two canonical Wnts, with the use of adenoviral vectors. However, this did not result in increased expression of S100A8 and S100A9, both on RNA and protein level. In contrast, we found that injection of S100A8 increased the expression of Wnt16 in the synovium and accumulation of β-catenin, a hallmark of canonical Wnt signaling, in both cartilage and synovium. In addition, the downstream mediator of canonical Wnt signaling WISP1, was increased. Furthermore, we found reduced β-catenin ...
Calprotectin is a 36kDa calcium and zinc binding protein expressed by the gene S100 calcium-binding protein A8, S100A8. It accounts for 30 to 40% of neutrophils cytosol. In vitro studies show it has bacteriostatic and fungistatic properties. It is...
Recombinant human S100B Calcium-Binding Protein, Western Blot Control protein - 230-00002-WBC. Liquid . Expression system is Escherichia coli (E.coli).

Gentaur Molecular :Accu \ Calgranulin B, Mab anti Human; Clone  CF 557, Biotin conj. \ ACL2712BGentaur Molecular :Accu \ Calgranulin B, Mab anti Human; Clone CF 557, Biotin conj. \ ACL2712B

Calgranulin B, Mab anti_Human; Clone CF_557, Biotin conj. \ ACL2712B for more molecular products just contact us ... Index / Accu / Calgranulin B, Mab anti_Human; Clone CF_557, Biotin conj. / Product Detail : ACL2712B Calgranulin B, Mab anti_ ... We have also other products like : Calgranulin B, Mab anti_Human; Clone CF_557, Biotin conj.. Related products : Calgranulin B ... Calgranulin B, Mab anti_Human; Clone CF_557, Biotin conj. Human samples 80 % of the research is conducted on human samples. ...
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Calgranulin - WikipediaCalgranulin - Wikipedia

S100A8 (calgranulin A) S100A9 (calgranulin B) S100A12 (calgranulin C) Some in vitro evidence suggests that calgranulin can ... Calgranulin A at the US National Library of Medicine Medical Subject Headings (MeSH) Calgranulin B at the US National Library ... Calgranulin is an S100 calcium-binding protein that is expressed in multiple cell types, including renal epithelial cells and ... Measurement of faecal calprotectin Pillay S, Asplin J, Coe F (1 August 1998). "Evidence that calgranulin is produced by kidney ...
more infohttps://en.wikipedia.org/wiki/Calgranulin

Calgranulin-B | definition of calgranulin-B by Medical dictionaryCalgranulin-B | definition of calgranulin-B by Medical dictionary

... calgranulin-B explanation free. What is calgranulin-B? Meaning of calgranulin-B medical term. What does calgranulin-B mean? ... Looking for online definition of calgranulin-B in the Medical Dictionary? ... Calgranulin-B , definition of calgranulin-B by Medical dictionary https://medical-dictionary.thefreedictionary.com/calgranulin- ... redirected from calgranulin-B) S100A9. A gene on chromosome 1q21 that encodes a member of the S100 family of proteins, which ...
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S100A9 / Calgranulin-B / MRP14 antibody | acris-antibodies.comS100A9 / Calgranulin-B / MRP14 antibody | acris-antibodies.com

Background of S100A9 / Calgranulin-B / MRP14 antibody. The calcium-binding, migration inhibitory factor-related proteins, MRP-8 ... Human tonsil Frozen section stained with Biotin conjugated S100A9 / Calgranulin-B / MRP14 Antibody Cat.-No BM4026B. *BM4026B ... Alternative names for S100A9 / Calgranulin-B / MRP14 antibody. S100-A9, CAGB, MRP-14, S100 calcium-binding protein A9, ...
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Study of Calgranulin A/B Levels in Patients With Newly Diagnosed Stage I,II,III Breast Cancer - Tabular View - ClinicalTrials...Study of Calgranulin A/B Levels in Patients With Newly Diagnosed Stage I,II,III Breast Cancer - Tabular View - ClinicalTrials...

RATIONALE: Measuring levels of calgranulin A and calgranulin B in the blood of patients with breast cancer in the laboratory ... PURPOSE: This laboratory study is measuring calgranulin A and calgranulin B levels in the blood of patients with newly ... Blood draw following diagnosis of breast cancer to assess levels of circulating tumor markers, calgranulin A and calgranulin B. ... Correlation between circulating levels of calgranulin A and calgranulin B and the presence of estrogen receptor negative breast ...
more infohttps://clinicaltrials.gov/ct2/show/record/NCT00900133

The Roles of Calprotectin and Calgranulin C in <i>Campylobacter jejuni by Janette..."The Roles of Calprotectin and Calgranulin C in <i>Campylobacter jejuni" by Janette...

Additionally, in response to infection, the neutrophil protein calgranulin C (S100A12) was found to be increased in the feces ... Additionally, in response to infection, the neutrophil protein calgranulin C (S100A12) was found to be increased in the feces ... Shank, Janette Marie, "The Roles of Calprotectin and Calgranulin C in Campylobacter jejuni Infection. " Masters Thesis, ...
more infohttps://trace.tennessee.edu/utk_gradthes/5001/

S100/Calgranulin-Mediated Inflammation Accelerates Left Ventricular Hypertrophy and Aortic Valve Sclerosis in Chronic Kidney...S100/Calgranulin-Mediated Inflammation Accelerates Left Ventricular Hypertrophy and Aortic Valve Sclerosis in Chronic Kidney...

S100/Calgranulin-Mediated Inflammation Accelerates Left Ventricular Hypertrophy and Aortic Valve Sclerosis in Chronic Kidney ... S100/Calgranulin-Mediated Inflammation Accelerates Left Ventricular Hypertrophy and Aortic Valve Sclerosis in Chronic Kidney ... S100/Calgranulin-Mediated Inflammation Accelerates Left Ventricular Hypertrophy and Aortic Valve Sclerosis in Chronic Kidney ... S100/Calgranulin-Mediated Inflammation Accelerates Left Ventricular Hypertrophy and Aortic Valve Sclerosis in Chronic Kidney ...
more infohttp://atvb.ahajournals.org/content/early/2014/05/22/ATVBAHA.114.303508

S100A12 (S100 calcium-binding protein A12, Calgranulin-C, CAGC, CGRP, Neutrophil S100 protein, Calcium-binding protein in...S100A12 (S100 calcium-binding protein A12, Calgranulin-C, CAGC, CGRP, Neutrophil S100 protein, Calcium-binding protein in...

S100A12 (EN-RAGE, calgranulin) is a member of the S100 protein family, which, in humans, consists of twenty five EF-hand (alpha ... You are here: Home Products by Molecule of Interest S100A12 (S100 calcium-binding protein A12, Calgranulin-C, CAGC, CGRP, ... References to S100A12 (S100 calcium-binding protein A12, Calgranulin-C, CAGC, CGRP, Neutrophil S100 protein, Calcium-binding ... S100A12 (S100 calcium-binding protein A12, Calgranulin-C, CAGC, CGRP, Neutrophil S100 protein, Calcium-binding protein in ...
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Gentaur Molecular :EIAab \ ELISA Calgranulin-B,Migration inhibitory factor-related protein 14,MRP14,MRP-14,Oryctolagus...Gentaur Molecular :EIAab \ ELISA Calgranulin-B,Migration inhibitory factor-related protein 14,MRP14,MRP-14,Oryctolagus...

ELISA Calgranulin-B,Migration inhibitory factor-related protein 14,MRP14,MRP-14,Oryctolagus cuniculus,p14,Protein S100-A9, ... ELISA Calgranulin-B,Migration inhibitory factor-related protein 14,MRP14,MRP-14,Oryctolagus cuniculus,p14,Protein S100-A9, ... Product name : ELISA Calgranulin-B,Migration inhibitory factor-related protein 14,MRP14,MRP-14,Oryctolagus cuniculus,p14, ... E1793Rb ELISA Calgranulin-B,Migration inhibitory factor-related protein 14,MRP14,MRP-14,Oryctolagus cuniculus,p14,Protein S100- ...
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Identification of myeloperoxidase, alpha-defensin and calgranulin in c by Shamim Mushtaq, Anwar Ali Siddiqui et al."Identification of myeloperoxidase, alpha-defensin and calgranulin in c" by Shamim Mushtaq, Anwar Ali Siddiqui et al.

Tandem mass spectrometry analysis identified them asmyeloperoxidase chain A (MPO-A), alpha-defensin, and calgranulin. ELISA, ... Tandem mass spectrometry analysis identified them asmyeloperoxidase chain A (MPO-A), alpha-defensin, and calgranulin. ELISA, ... Identification of myeloperoxidase, alpha-defensin and calgranulin in calcium oxalate renal stones. ... alpha-defensin and calgranulin in calcium oxalate renal stones.. Clinica Chemica Acta: International Journal of Clinical ...
more infohttps://ecommons.aku.edu/pakistan_fhs_mc_surg_urol/48/

Chicken S100A8 (S100 Calcium Binding Protein A8/Calgranulin A) ELISA Kit Manufacturers in DelhiChicken S100A8 (S100 Calcium Binding Protein A8/Calgranulin A) ELISA Kit Manufacturers in Delhi

S100 Calcium Binding Protein A8/Calgranulin A) ELISA Kit OSCAR DIAGNOSTIC SERVICES PVT. LTD.is an India based Company in Delhi. ... Chicken S100A8 (S100 Calcium Binding Protein A8/Calgranulin A) ELISA Kit » Chicken S100A8 (S100 Calcium Binding Protein A8/ ... Calgranulin A) ELISA Kit. Chicken S100A8 (S100 Calcium Binding Protein A8/Calgranulin A) ELISA Kit. Chicken S100A8 (S100 ... Chicken S100A8 (S100 Calcium Binding Protein A8/Calgranulin A) ELISA Kit. Chicken S100A8 (S100 Calcium Binding Protein A8/ ...
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Serum calgranulin C is a highly sensitive autoinflammation activity indicator in patients with familial periodic fevers].  -...Serum calgranulin C is a highly sensitive autoinflammation activity indicator in patients with familial periodic fevers]. -...

Serum calgranulin C is a highly sensitive autoinflammation activity indicator in patients with familial periodic fevers].. [ ... To determine the possibility of using the serum proinflammatory calcium-binding protein, or calgranulin C (S100A12), to assess ...
more infohttps://phgkb.cdc.gov/PHGKB/phgHome.action?action=forward&dbsource=huge&id=132521

Anti-CP-10 Antibody Products | Biocompare.comAnti-CP-10 Antibody Products | Biocompare.com

Calgranulin-A; CAGA; CGLA; MA387; NIF. The encoded protein has an amino acid length of 93 and a mass of 10.8 kDa. CP-10 is a ...
more infohttps://www.biocompare.com/pfu/110447/soids/35041/Antibodies/CP-10

CP-10 ELISA Kits | Biocompare.comCP-10 ELISA Kits | Biocompare.com

Mouse S100A8/Calgranulin A PicoKine ELISA Kit *Detection Target: Protein S100-A8 ...
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Patent US8492107 - Neural proteins as biomarkers for nervous system injury and other neural ... - Google PatentsPatent US8492107 - Neural proteins as biomarkers for nervous system injury and other neural ... - Google Patents

Calgranulin AB, alpha-Synuelein (P37377), beta-Synuclein (Q63754), HNP 22; Neural nuclear proteins: NeuN-1, S/G(2) nuclear ... Calgranulin AB, alpha-Synuclein (P37377), beta-Synuclein (Q63754), HNP 22; Neural nuclear proteins: NeuN-1, S/G(2) nuclear ... Calgranulin AB, alpha-Synuclein (P37377), beta-Synuclein (Q63754), HNP 22; Neural nuclear proteins: NeuN-1, S/G(2) nuclear ... Calgranulin AB, alpha-Synuclein (P37377), beta-Synuclein (Q63754), HNP 22; Neural nuclear proteins: NeuN-1, S/G(2) nuclear ...
more infohttp://www.google.ca/patents/US8492107

SALIVARY PROTEIN BIOMARKERS FOR HUMAN ORAL CANCER - The Regents of the University of CaliforniaSALIVARY PROTEIN BIOMARKERS FOR HUMAN ORAL CANCER - The Regents of the University of California

4. The method of any one of claims 1 to 3, wherein said method comprises the detection of M2BP, calgranulin B, CD59, profilin, ... In another particular embodiment, the methods of the invention comprise the detection of M2BP, calgranulin B, CD59, profilin, ... The discovered candidate biomarkers include calgranulin A, serum amyloid A-4 protein and related isoforms, haptoglobin-related ... Further validation of calgranulin A by ELISA (n=20 for each group, p=0.039) and tetranectin by immunoblotting (n=35 for each ...
more infohttp://www.freepatentsonline.com/y2011/0021370.html

Recombinant Human S100A9 protein (ab95909) | AbcamRecombinant Human S100A9 protein (ab95909) | Abcam

S100 calcium binding protein A9 calgranulin B. *S100 calcium-binding protein A9 ...
more infohttp://www.abcam.com/recombinant-human-s100a9-protein-ab95909.html

S100A9 Gene - GeneCards | S10A9 Protein | S10A9 AntibodyS100A9 Gene - GeneCards | S10A9 Protein | S10A9 Antibody

S100 calcium binding protein A9,calgranulin B,epidermal differentiation complex expressed in monocytes and granulocytes *S100A9 ...
more infohttps://www.genecards.org/cgi-bin/carddisp.pl?gene=S100A9

Protein S100-A9 - DrugBankProtein S100-A9 - DrugBank

Calgranulin-B. *Calprotectin L1H subunit. *CFAG. *Leukocyte L1 complex heavy chain. *Migration inhibitory factor-related ...
more infohttps://www.drugbank.ca/polypeptides/P06702

Calprotectin Antibody (MA1-91321)
                
                
		        
	Calprotectin Antibody (MA1-91321)

Protein Aliases: 60B8Ag; AI323541; B8Ag; BEE11; Caga; calgranulin B; Calgranulin-A; Calgranulin-B; calprotectin; Calprotectin ... calgranulin B); S100 calcium-binding protein A8; S100 calcium-binding protein A9; S100 calcium-binding protein A9 (calgranulin ...
more infohttps://www.thermofisher.com/antibody/product/Calprotectin-Antibody-clone-MAC387-Monoclonal/MA1-91321

Fecal calprotectin | Radiology Reference Article | Radiopaedia.orgFecal calprotectin | Radiology Reference Article | Radiopaedia.org

Calgranulin. *Cystic fibrosis associated antigen (CFA). *Calgranulin A. *Calgranulin B. *S-100a ...
more infohttps://radiopaedia.org/articles/faecal-calprotectin

Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and...Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and...

This study undertakes a systematic and comprehensive analysis of brain gene expression profiles of immune/inflammation-related genes in aging and Alzheimers disease (AD). In a well-powered microarray study of young (20 to 59 years), aged (60 to 99 years), and AD (74 to 95 years) cases, gene responses were assessed in the hippocampus, entorhinal cortex, superior frontal gyrus, and post-central gyrus. Several novel concepts emerge. First, immune/inflammation-related genes showed major changes in gene expression over the course of cognitively normal aging, with the extent of gene response far greater in aging than in AD. Of the 759 immune-related probesets interrogated on the microarray, approximately 40% were significantly altered in the SFG, PCG and HC with increasing age, with the majority upregulated (64 to 86%). In contrast, far fewer immune/inflammation genes were significantly changed in the transition to AD (approximately 6% of immune-related probesets), with gene responses primarily restricted to
more infohttps://jneuroinflammation.biomedcentral.com/articles/10.1186/1742-2094-9-179

Diabetes insipidus emedicine treatmentDiabetes insipidus emedicine treatment

... some researchers have found that the molecule calgranulin is able to inhibit calcium oxalate crystal growth.[41] Calgranulin is ... Given the large amounts of calcium oxalate in the urine, and considering its potency, calgranulin could become an important ...
more infohttp://s3.amazonaws.com/brat4drdiabete/diabetes-insipidus-emedicine-treatment.html