Macrophages: The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)Sister Mary Joseph's Nodule: Metastatic lesion of the UMBILICUS associated with intra-abdominal neoplasms especially of the GASTROINTESTINAL TRACT or OVARY.Umbilicus: The pit in the center of the ABDOMINAL WALL marking the point where the UMBILICAL CORD entered in the FETUS.Bence Jones Protein: An abnormal protein with unusual thermosolubility characteristics that is found in the urine of patients with MULTIPLE MYELOMA.Macrophage Activation: The process of altering the morphology and functional activity of macrophages so that they become avidly phagocytic. It is initiated by lymphokines, such as the macrophage activation factor (MAF) and the macrophage migration-inhibitory factor (MMIF), immune complexes, C3b, and various peptides, polysaccharides, and immunologic adjuvants.Multiple Organ Failure: A progressive condition usually characterized by combined failure of several organs such as the lungs, liver, kidney, along with some clotting mechanisms, usually postinjury or postoperative.Calcium Signaling: Signal transduction mechanisms whereby calcium mobilization (from outside the cell or from intracellular storage pools) to the cytoplasm is triggered by external stimuli. Calcium signals are often seen to propagate as waves, oscillations, spikes, sparks, or puffs. The calcium acts as an intracellular messenger by activating calcium-responsive proteins.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.HandbooksPublishing: "The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.BooksRandomized Controlled Trials as Topic: Works about clinical trials that involve at least one test treatment and one control treatment, concurrent enrollment and follow-up of the test- and control-treated groups, and in which the treatments to be administered are selected by a random process, such as the use of a random-numbers table.Neurobiology: The study of the structure, growth, activities, and functions of NEURONS and the NERVOUS SYSTEM.Authorship: The profession of writing. Also the identity of the writer as the creator of a literary production.Calcium: A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.Calcium Channels: Voltage-dependent cell membrane glycoproteins selectively permeable to calcium ions. They are categorized as L-, T-, N-, P-, Q-, and R-types based on the activation and inactivation kinetics, ion specificity, and sensitivity to drugs and toxins. The L- and T-types are present throughout the cardiovascular and central nervous systems and the N-, P-, Q-, & R-types are located in neuronal tissue.Models, Biological: Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.Biological Evolution: The process of cumulative change over successive generations through which organisms acquire their distinguishing morphological and physiological characteristics.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Signal Transduction: The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.Child Development: The continuous sequential physiological and psychological maturing of an individual from birth up to but not including ADOLESCENCE.Cellular Phone: Analog or digital communications device in which the user has a wireless connection from a telephone to a nearby transmitter. It is termed cellular because the service area is divided into multiple "cells." As the user moves from one cell area to another, the call is transferred to the local transmitter.Neuropsychological Tests: Tests designed to assess neurological function associated with certain behaviors. They are used in diagnosing brain dysfunction or damage and central nervous system disorders or injury.Mobile Applications: Computer programs or software installed on mobile electronic devices which support a wide range of functions and uses which include television, telephone, video, music, word processing, and Internet service.Computers, Handheld: A type of MICROCOMPUTER, sometimes called a personal digital assistant, that is very small and portable and fitting in a hand. They are convenient to use in clinical and other field situations for quick data management. They usually require docking with MICROCOMPUTERS for updates.Second Messenger Systems: Systems in which an intracellular signal is generated in response to an intercellular primary messenger such as a hormone or neurotransmitter. They are intermediate signals in cellular processes such as metabolism, secretion, contraction, phototransduction, and cell growth. Examples of second messenger systems are the adenyl cyclase-cyclic AMP system, the phosphatidylinositol diphosphate-inositol triphosphate system, and the cyclic GMP system.Nucleus Accumbens: Collection of pleomorphic cells in the caudal part of the anterior horn of the LATERAL VENTRICLE, in the region of the OLFACTORY TUBERCLE, lying between the head of the CAUDATE NUCLEUS and the ANTERIOR PERFORATED SUBSTANCE. It is part of the so-called VENTRAL STRIATUM, a composite structure considered part of the BASAL GANGLIA.Dopamine: One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and EPINEPHRINE. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (RECEPTORS, DOPAMINE) mediate its action.Reward: An object or a situation that can serve to reinforce a response, to satisfy a motive, or to afford pleasure.Cyclic AMP: An adenine nucleotide containing one phosphate group which is esterified to both the 3'- and 5'-positions of the sugar moiety. It is a second messenger and a key intracellular regulator, functioning as a mediator of activity for a number of hormones, including epinephrine, glucagon, and ACTH.Rats, Sprague-Dawley: A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.Systems Biology: Comprehensive, methodical analysis of complex biological systems by monitoring responses to perturbations of biological processes. Large scale, computerized collection and analysis of the data are used to develop and test models of biological systems.DNA Repair: The reconstruction of a continuous two-stranded DNA molecule without mismatch from a molecule which contained damaged regions. The major repair mechanisms are excision repair, in which defective regions in one strand are excised and resynthesized using the complementary base pairing information in the intact strand; photoreactivation repair, in which the lethal and mutagenic effects of ultraviolet light are eliminated; and post-replication repair, in which the primary lesions are not repaired, but the gaps in one daughter duplex are filled in by incorporation of portions of the other (undamaged) daughter duplex. Excision repair and post-replication repair are sometimes referred to as "dark repair" because they do not require light.Circadian Rhythm Signaling Peptides and Proteins: A broad category of proteins that regulate the CIRCADIAN RHYTHM of an organism. Included here are proteins that transmit intracellular and intercellular signals in a chronological manner along with proteins that sense light and time-dependent changes in the environment such as the PHOTOPERIOD.DNA Damage: Injuries to DNA that introduce deviations from its normal, intact structure and which may, if left unrepaired, result in a MUTATION or a block of DNA REPLICATION. These deviations may be caused by physical or chemical agents and occur by natural or unnatural, introduced circumstances. They include the introduction of illegitimate bases during replication or by deamination or other modification of bases; the loss of a base from the DNA backbone leaving an abasic site; single-strand breaks; double strand breaks; and intrastrand (PYRIMIDINE DIMERS) or interstrand crosslinking. Damage can often be repaired (DNA REPAIR). If the damage is extensive, it can induce APOPTOSIS.Phosphatidylinositols: Derivatives of phosphatidic acids in which the phosphoric acid is bound in ester linkage to the hexahydroxy alcohol, myo-inositol. Complete hydrolysis yields 1 mole of glycerol, phosphoric acid, myo-inositol, and 2 moles of fatty acids.Dissertations, Academic as Topic: Dissertations embodying results of original research and especially substantiating a specific view, e.g., substantial papers written by candidates for an academic degree under the individual direction of a professor or papers written by undergraduates desirous of achieving honors or distinction.Inositol 1,4,5-Trisphosphate: Intracellular messenger formed by the action of phospholipase C on phosphatidylinositol 4,5-bisphosphate, which is one of the phospholipids that make up the cell membrane. Inositol 1,4,5-trisphosphate is released into the cytoplasm where it releases calcium ions from internal stores within the cell's endoplasmic reticulum. These calcium ions stimulate the activity of B kinase or calmodulin.Boron Compounds: Inorganic or organic compounds that contain boron as an integral part of the molecule.Photoreceptor Cells, Invertebrate: Specialized cells in the invertebrates that detect and transduce light. They are predominantly rhabdomeric with an array of photosensitive microvilli. Illumination depolarizes invertebrate photoreceptors by stimulating Na+ influx across the plasma membrane.Drosophila: A genus of small, two-winged flies containing approximately 900 described species. These organisms are the most extensively studied of all genera from the standpoint of genetics and cytology.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Drosophila Proteins: Proteins that originate from insect species belonging to the genus DROSOPHILA. The proteins from the most intensely studied species of Drosophila, DROSOPHILA MELANOGASTER, are the subject of much interest in the area of MORPHOGENESIS and development.Signal Detection, Psychological: Psychophysical technique that permits the estimation of the bias of the observer as well as detectability of the signal (i.e., stimulus) in any sensory modality. (From APA, Thesaurus of Psychological Index Terms, 8th ed.)Phosphatidylinositol 3-Kinases: Phosphotransferases that catalyzes the conversion of 1-phosphatidylinositol to 1-phosphatidylinositol 3-phosphate. Many members of this enzyme class are involved in RECEPTOR MEDIATED SIGNAL TRANSDUCTION and regulation of vesicular transport with the cell. Phosphatidylinositol 3-Kinases have been classified both according to their substrate specificity and their mode of action within the cell.PTEN Phosphohydrolase: A lipid phosphatase that acts on phosphatidylinositol-3,4,5-trisphosphate to regulate various SIGNAL TRANSDUCTION PATHWAYS. It modulates CELL GROWTH PROCESSES; CELL MIGRATION; and APOPTOSIS. Mutations in PTEN are associated with COWDEN DISEASE and PROTEUS SYNDROME as well as NEOPLASTIC CELL TRANSFORMATION.Cardiovascular Diseases: Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.Receptors, Calcitriol: Proteins, usually found in the cytoplasm, that specifically bind calcitriol, migrate to the nucleus, and regulate transcription of specific segments of DNA with the participation of D receptor interacting proteins (called DRIP). Vitamin D is converted in the liver and kidney to calcitriol and ultimately acts through these receptors.Calcitriol: The physiologically active form of vitamin D. It is formed primarily in the kidney by enzymatic hydroxylation of 25-hydroxycholecalciferol (CALCIFEDIOL). Its production is stimulated by low blood calcium levels and parathyroid hormone. Calcitriol increases intestinal absorption of calcium and phosphorus, and in concert with parathyroid hormone increases bone resorption.Sunlight: Irradiation directly from the sun.Dihydroxycholecalciferols: Cholecalciferols substituted with two hydroxy groups in any position.Dehydrocholesterols: Cholesterol derivatives having an additional double bond in any position. 24-Dehydrocholesterol is DESMOSTEROL. The other most prevalent dehydrocholesterol is the 7-isomer. This compound is a precursor of cholesterol and of vitamin D3.Vitamin D: A vitamin that includes both CHOLECALCIFEROLS and ERGOCALCIFEROLS, which have the common effect of preventing or curing RICKETS in animals. It can also be viewed as a hormone since it can be formed in SKIN by action of ULTRAVIOLET RAYS upon the precursors, 7-dehydrocholesterol and ERGOSTEROL, and acts on VITAMIN D RECEPTORS to regulate CALCIUM in opposition to PARATHYROID HORMONE.Dactinomycin: A compound composed of a two CYCLIC PEPTIDES attached to a phenoxazine that is derived from STREPTOMYCES parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy. (From AMA Drug Evaluations Annual, 1993, p2015)

BLNK required for coupling Syk to PLC gamma 2 and Rac1-JNK in B cells. (1/8321)

Signaling through the B cell receptor (BCR) is essential for B cell function and development. Despite the key role of Syk in BCR signaling, little is known about the mechanism by which Syk transmits downstream effectors. BLNK (B cell LiNKer protein), a substrate for Syk, is now shown to be essential in activating phospholipase C (PLC)gamma 2 and JNK. The BCR-induced PLC gamma 2 activation, but not the JNK activation, was restored by introduction of PLC gamma 2 membrane-associated form into BLNK-deficient B cells. As JNK activation requires both Rac1 and PLC gamma 2, our results suggest that BLNK regulates the Rac1-JNK pathway, in addition to modulating PLC gamma 2 localization.  (+info)

Skeletal muscle type ryanodine receptor is involved in calcium signaling in human B lymphocytes. (2/8321)

The regulation of intracellular free Ca2+ concentration ([Ca2+]i) in B cells remains poorly understood and is presently explained almost solely by inositol 1,4,5-triphosphate (IP3)-mediated Ca2+ release, followed by activation of a store-operated channel mechanism. In fact, there are reports indicating that IP3 production does not always correlate with the magnitude of Ca2+ release. We demonstrate here that human B cells express a ryanodine receptor (RYR) that functions as a Ca2+ release channel during the B cell antigen receptor (BCR)-stimulated Ca2+ signaling process. Immunoblotting studies showed that both human primary CD19(+) B and DAKIKI cells express a 565-kDa immunoreactive protein that is indistinguishable in molecular size and immunoreactivity from the RYR. Selective reverse transcription-polymerase chain reaction, restriction fragment length polymorphism, and sequencing of cloned cDNA indicated that the major isoform of the RYR expressed in primary CD19(+) B and DAKIKI cells is identical to the skeletal muscle type (RYR1). Saturation analysis of [3H]ryanodine binding yielded Bmax = 150 fmol/mg of protein and Kd = 110 nM in DAKIKI cells. In fluo-3-loaded CD19(+) B and DAKIKI cells, 4-chloro-m-cresol, a potent activator of Ca2+ release mediated by the ryanodine-sensitive Ca2+ release channel, induced Ca2+ release in a dose-dependent and ryanodine-sensitive fashion. Furthermore, BCR-mediated Ca2+ release in CD19(+) B cells was significantly altered by 4-chloro-m-cresol and ryanodine. These results indicate that RYR1 functions as a Ca2+ release channel during BCR-stimulated Ca2+ signaling and suggest that complex Ca2+ signals that control the cellular activities of B cells may be generated by cooperation of the IP3 receptor and RYR1.  (+info)

Characterization of elementary Ca2+ release signals in NGF-differentiated PC12 cells and hippocampal neurons. (3/8321)

Elementary Ca2+ release signals in nerve growth factor- (NGF-) differentiated PC12 cells and hippocampal neurons, functionally analogous to the "Ca2+ sparks" and "Ca2+ puffs" identified in other cell types, were characterized by confocal microscopy. They either occurred spontaneously or could be activated by caffeine and metabotropic agonists. The release events were dissimilar to the sparks and puffs described so far, as many arose from clusters of both ryanodine receptors (RyRs) and inositol 1,4,5-trisphosphate receptors (InsP3Rs). Increasing either the stimulus strength or loading of the intracellular stores enhanced the frequency of and coupling between elementary release sites and evoked global Ca2+ signals. In the PC12 cells, the elementary Ca2+ release preferentially occurred around the branch points. Spatio-temporal recruitment of such elementary release events may regulate neuronal activities.  (+info)

The beta subunit increases the Ca2+ sensitivity of large conductance Ca2+-activated potassium channels by retaining the gating in the bursting states. (4/8321)

Coexpression of the beta subunit (KV,Cabeta) with the alpha subunit of mammalian large conductance Ca2+- activated K+ (BK) channels greatly increases the apparent Ca2+ sensitivity of the channel. Using single-channel analysis to investigate the mechanism for this increase, we found that the beta subunit increased open probability (Po) by increasing burst duration 20-100-fold, while having little effect on the durations of the gaps (closed intervals) between bursts or on the numbers of detected open and closed states entered during gating. The effect of the beta subunit was not equivalent to raising intracellular Ca2+ in the absence of the beta subunit, suggesting that the beta subunit does not act by increasing all the Ca2+ binding rates proportionally. The beta subunit also inhibited transitions to subconductance levels. It is the retention of the BK channel in the bursting states by the beta subunit that increases the apparent Ca2+ sensitivity of the channel. In the presence of the beta subunit, each burst of openings is greatly amplified in duration through increases in both the numbers of openings per burst and in the mean open times. Native BK channels from cultured rat skeletal muscle were found to have bursting kinetics similar to channels expressed from alpha subunits alone.  (+info)

Fertilization, embryonic development, and offspring from mouse eggs injected with round spermatids combined with Ca2+ oscillation-inducing sperm factor. (5/8321)

Round spermatids, precursor male gametes, are known to possess the potential to achieve fertilization and embryonic development when injected into eggs. However, injection of spermatids alone seldom activates eggs in the mouse, as spermatids by themselves cannot induce an increase in intracellular Ca2+, a prerequisite for egg activation. We injected a mouse round spermatid into an egg simultaneously with partially purified sperm factor from differentiated hamster spermatozoa. The combined injection produced repetitive Ca2+ increases (Ca2+ oscillations) lasting for at least 4 h as observed at fertilization, and induced activation in 92% of eggs. This method provided 75% fertilization success associated with male and female pronucleus formation and development to 2-cell embryos, while only 7% of eggs were fertilized by injection of a spermatid alone. Of the 2-cell embryos, approximately 50% developed to blastocysts during 5 days of culture in vitro, while no blastocysts were obtained following injection of sperm factor alone. Furthermore, the 2-cell embryos, that were created by spermatids and sperm factor and transplanted into foster mothers, developed into normal offspring, although the percentage was only 22%. All infants grew into healthy adults carrying normal chromosomes. The sperm factor served as a complementary factor for successful fertilization by round spermatid injection.  (+info)

Contributions of mitochondria to animal physiology: from homeostatic sensor to calcium signalling and cell death. (6/8321)

Over recent years, it has become clear that mitochondria play a central role in many key aspects of animal physiology and pathophysiology. Their central and ubiquitous task is clearly the production of ATP. Nevertheless, they also play subtle roles in glucose homeostasis, acting as the sensor for substrate supply in the transduction pathway that promotes insulin secretion by the pancreatic -cell and that modulates the excitability of the hypothalamic glucose-sensitive neurons involved in appetite control. Mitochondria may also act as sensors of availability of oxygen, the other major mitochondrial substrate, in the regulation of respiration. Mitochondria take up calcium, and the high opacity mitochondrial calcium uptake pathway provides a mechanism that couples energy demand to increased ATP production through the calcium-dependent upregulation of mitochondrial enzyme activity. Mitochondrial calcium accumulation may also have a substantial impact on the spatiotemporal dynamics of cellular calcium signals, with subtle differences of detail in different cell types. Recent work has also revealed the centrality of mitochondrial dysfunction as an irreversible step in the pathway to both necrotic and apoptotic cell death. This review looks at recent developments in these rapidly evolving areas of cell physiology in an attempt to draw together disparate areas of research into a common theme.  (+info)

Isosmotic modulation of Ca2+-regulated exocytosis in guinea-pig antral mucous cells: role of cell volume. (7/8321)

1. Exocytotic events and changes of cell volume in mucous cells from guinea-pig antrum were examined by video-enhanced optical microscopy. 2. Acetylcholine (ACh) evoked exocytotic events following cell shrinkage, the frequency and extent of which depended on the ACh concentration. ACh actions were mimicked by ionomycin and thapsigargin, and inhibited by Ca2+-free solution and Ca2+ channel blockers (Ni2+, Cd2+ and nifedipine). Application of 100 microM W-7, a calmodulin inhibitor, also inhibited the ACh-induced exocytotic events. These results indicate that ACh actions are mediated by intracellular Ca2+ concentration ([Ca2+]i) in antral mucous cells. 3. The effects of ion channel blockers on exocytotic events and cell shrinkage evoked by ACh were examined. Inhibition of KCl release (quinine, Ba2+, NPPB or KCl solution) suppressed both the exocytotic events and cell shrinkage evoked by ACh. 4. Bumetanide (inhibition of NaCl entry) or Cl--free solution (increasing Cl- release and inhibition of NaCl entry) evoked exocytotic events following cell shrinkage in unstimulated antral mucous cells and caused further cell shrinkage and increases in the frequency of exocytotic events in ACh-stimulated cells. However, Cl--free solution did not evoke exocytotic events in unstimulated cells in the absence of extracellular Ca2+, although cell shrinkage occurred. 5. To examine the effects of cell volume on ACh-evoked exocytosis, the cell volume was altered by increasing the extracellular K+ concentration. The results showed that cell shrinkage increases the frequency of ACh-evoked exocytotic events and cell swelling decreases them. 6. Osmotic shrinkage or swelling caused the frequency of ACh-evoked exocytotic events to increase. This suggests that the effects of cell volume on ACh-evoked exocytosis under anisosmotic conditions may not be the same as those under isosmotic conditions. 7. In antral mucous cells, Ca2+-regulated exocytosis is modulated by cell shrinkage under isosmotic conditions.  (+info)

Relationship between L-type Ca2+ current and unitary sarcoplasmic reticulum Ca2+ release events in rat ventricular myocytes. (8/8321)

1. The time courses of Ca2+ current and Ca2+ spark occurrence were determined in single rat ventricular myocytes voltage clamped with patch pipettes containing 0.1 microM fluo-3. Acquisition of line-scan images on a laser scanning confocal microscope was synchronized with measurement of Cd2+-sensitive Ca2+ currents. In most cells, individual Ca2+ sparks were observed by reducing Ca2+ current density with nifedipine (0.1-8 microM). 2. Ca2+ sparks elicited by depolarizing voltage-clamp pulses had a peak [Ca2+] amplitude of 289 +/- 3 nM with a decay half-time of 20.8 +/- 0.2 ms and a full width at half-maximum of 1.40 +/- 0.03 microm (mean +/- s. e.m., n = 345), independent of the membrane potential. 3. The time between the beginning of a depolarization and the initiation of each Ca2+ spark was calculated and data were pooled to construct waiting time histograms. Exponential functions were fitted to these histograms and to the decaying phase of the Ca2+ current. This analysis showed that the time constants describing Ca2+ current and Ca2+ spark occurrence at membrane potentials between -30 mV and +30 mV were not significantly different. At +50 mV, in the absence of nifedipine, the time constant describing Ca2+ spark occurrence was significantly larger than the time constant of the Ca2+ current. 4. A simple model is developed using Poisson statistics to relate macroscopic Ca2+ current to the opening of single L-type Ca2+ channels at the dyad junction and to the time course of Ca2+ spark occurrence. The model suggests that the time courses of macroscopic Ca2+ current and Ca2+ spark occurrence should be closely related when opening of a single L-type Ca2+ channel initiates a Ca2+ spark. By comparison with the data, the model suggests that Ca2+ sparks are initiated by the opening of a single L-type Ca2+ channel at all membrane potentials encountered during an action potential.  (+info)

*Cofactor (biochemistry)

Clapham DE (2007). "Calcium signaling". Cell. 131 (6): 1047-58. doi:10.1016/j.cell.2007.11.028. PMID 18083096.. ... Calcium is, therefore, a cell signaling molecule, and not usually considered a cofactor of the enzymes it regulates.[16] ... Niki I, Yokokura H, Sudo T, Kato M, Hidaka H (October 1996). "Ca2+ signaling and intracellular Ca2+ binding proteins". Journal ... Calcium is another special case, in that it is required as a component of the human diet, and it is needed for the full ...

*Calcium hydroxide

GHS signal word Danger GHS hazard statements. H314, H318, H335, H402 GHS precautionary statements ... which decomposes calcium hydroxide into calcium oxide and water.[7] Ca(OH)2 → CaO + H2O. Structure, preparation, occurrence[ ... Calcium hydroxide (traditionally called slaked lime) is an inorganic compound with the chemical formula Ca(OH)2. It is a ... "MSDS Calcium hydroxide" (PDF). Archived from the original (PDF) on 25 March 2012. Retrieved 21 June 2011.. Cite uses deprecated ...

*TFEB

"Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB". Nature Cell Biology. 17 (3): 288-99. doi: ... "Science Signaling. 5 (228): ra42. doi:10.1126/scisignal.2002790. PMC 3437338. PMID 22692423.. ... Nuclear localization and activity of TFEB is inhibited by serine phosphorylation by mTORC1 and extracellular signal-regulated ... "Modelling TFE renal cell carcinoma in mice reveals a critical role of WNT signaling". eLife. 5. doi:10.7554/eLife.17047. PMC ...

*Low-threshold spikes

Calcium Signaling. Advances in Experimental Medicine and Biology. 740. pp. 1219-47. doi:10.1007/978-94-007-2888-2_55. ISBN 978- ... Antiepileptic drugs can control absence seizures by inhibiting the T-type calcium channels which prevents low-voltage calcium ... T-type calcium channels have been known to play a role in the spike-and-wave discharges of absence seizures. ... The T-type calcium channel is found in neurons throughout the brain. These channels produce particularly large currents in ...

*Cofactor (biochemistry)

Calcium is, therefore, a cell signaling molecule, and not usually considered a cofactor of the enzymes it regulates. Other ... Clapham DE (2007). "Calcium signaling". Cell. 131 (6): 1047-58. doi:10.1016/j.cell.2007.11.028. PMID 18083096. Niki I, Yokokura ... Calcium is another special case, in that it is required as a component of the human diet, and it is needed for the full ... H, Sudo T, Kato M, Hidaka H (1996). "Ca2+ signaling and intracellular Ca2+ binding proteins". J. Biochem. 120 (4): 685-98. doi: ...

*SSH1

Wang Y, Shibasaki F, Mizuno K (2005). "Calcium signal-induced cofilin dephosphorylation is mediated by Slingshot via ...

*Fluo-3

Calcium Signaling Protocols. Humana Press, 2006. ... Cheng, H.; Lederer, W.J.; Cannell, M.B. (1993). "Calcium Sparks ... Fluo-3 is a fluorescence indicator of intracellular calcium (Ca2+). It is used to measure Ca2+ inside living cells in flow ... Once inside the cell, unspecific esterases cleave the ester effectively trapping fluo-3. As calcium is a key second messenger ... Molecular Probes, 2010 Gamsjäger, T. Flow Cytometry of Intracellular Calcium in Platelets. Grin, 2012 Lambert, DG. ...

*Chromosome 1

TACSTD2: tumor-associated calcium signal transducer 2. *TAL1 (1p33). *TCEB3: Transcription elongation factor B polypeptide 3 ... Patterns of sequence variation reveal signals of recent selection in specific genes that may contribute to human fitness, and ...

*TAS2R14

"Bitter taste receptors on airway smooth muscle bronchodilate by localized calcium signaling and reverse obstruction". Nat. Med ... signal transduction. • response to stimulus. • sensory perception of taste. • G-protein coupled receptor signaling pathway. ... signal transducer activity. • taste receptor activity. • bitter taste receptor activity. Cellular component. • plasma membrane ... Their activation in these cells causes an increase in intracellular calcium ion, which in turn triggers the opening of ...

*Tmem110

... is a positive modulator of calcium flux mediated by the STIM-ORAI signaling in vertebrates. STIMATE can physically ... Oh-hora, Masatsugu; Rao, Anjana (2008-01-01). "Calcium signaling in lymphocytes". Current Opinion in Immunology. 20 (3): 250- ... reduces the puncta formation of STIM1 at ER-PM junctions and remarkably inhibits the calcium/calcineurin/NFAT signaling axis. ... thereby coupling to and gating the ORAI calcium channels on the plasma membrane. Depletion of TMEM110 with RNAi knockdown or ...

*Pathophysiology of Parkinson's disease

doi:10.1002/jcp.20647 Marambaud, P., Dreses-Werringloer, U., & Vingtdeux, V. (2009). Calcium signaling in neurodegeneration. ... The activated motor neurons then transmit their signals, via action potential, to motor neurons in the legs. However, when a ... During this time, microglia generate reactive oxygen species and release signals to recruit peripheral immune cells for an ... doi:10.1038/nrn3114 Hao, T., & Rockwell, P. (2013). Signaling through the vascular endothelial growth factor receptor VEGFR-2 ...

*Bruton's tyrosine kinase

apoptotic signaling pathway. • calcium-mediated signaling. • I-kappaB kinase/NF-kappaB signaling. • innate immune system. • ... B cell receptor signaling pathway. • Fc-epsilon receptor signaling pathway. • regulation of cell proliferation. • adaptive ... transmembrane receptor protein tyrosine kinase signaling pathway. • mesoderm development. • intracellular signal transduction. ... functional significance of Btk-SH2 domain in B-cell antigen receptor-coupled calcium signaling". Blood. 94 (7): 2357-64. PMID ...

*Heterosynaptic plasticity

2012.) Calcium Signaling in Dendritic Spines. Cold Spring Harbor Perspectives in Biology. Retrieved from http://cshperspectives ... Therefore, heterosynaptic dopamine signaling in mammals can be best represented by dopamine's biological functions of mediating ...

*Homosynaptic plasticity

2012.) Calcium Signaling in Dendritic Spines. Cold Spring Harbor Perspectives in Biology. Retrieved from http://cshperspectives ... Ca2+ is one signaling ion that causes this AMPA receptor density change by inducing a cascade of biological changes within the ... According to Hebb, these two cells are strengthened because their signaling occurs together in space and/or time, also known as ... In order to create input-specific changes in synaptic strength, the Ca2+ signal must be restricted to specific dendritic spines ...

*Antony Galione

He established that cyclic ADP-ribose regulates calcium-induced calcium release and globalisation of calcium signals, and that ... Galione's research investigates calcium signalling. He established the concept of multiple calcium mobilising messengers which ... The discovery of lysosomes as calcium stores mobilised by NAADP has identified an entirely new signalling role for these ... in 1985 followed by a PhD in 1989 for research on calcium signalling in the blowfly salivary gland supervised by Michael ...

*Mitochondrial membrane transport protein

Mitochondria and calcium signaling. Cell Calcium, Volume 38, Issues 3-4, Pages 311-317. PMID 16087232. Retrieved on January 23 ... load and oxidative stress The mitochondrial calcium uniporter which transports calcium from the cytosol of the cell into the ... which opens in response to increased mitochondrial calcium (Ca2+) ... mitochondrial matrix The mitochondrial sodium/calcium exchanger, which carries Ca2+ ions out of the matrix in exchange for Na+ ...

*Inositol-trisphosphate 3-kinase

In this way, IP4 may actually serve to prolong the calcium signal by activating the influx of calcium stores from the ... plays a vital role in the calcium signalling pathway by terminating the propagation of the signal caused by IP3 by converting ... Therefore, calcium homeostasis is essential for proper cell function and response to extracellular signals. In order to prepare ... ITP3K plays a role in the calcium signaling pathway. In this pathway, either a G-protein coupled receptor (GPCR) or receptor ...

*Adrenal gland

"Calcium signaling and exocytosis in adrenal chromaffin cells". Physiological Reviews. 86 (4): 1093-1131. doi:10.1152/physrev. ... signal integration by extracellular signal regulated kinases1/2". Journal of Molecular Endocrinology. 42 (3): 191-203. doi: ... Cortisol reduces the capacity of osteoblasts to produce new bone tissue and decreases the absorption of calcium in the ... When activated, it evokes the release of catecholamines from the storage granules by stimulating the opening of calcium ...

*3S,6E)-nerolidolna sintaza - Википедија, слободна енциклопедија

... ethylene and calcium signaling". Planta. 227: 453-464. PMID 17924138.. CS1 одржавање: Вишеструка имена: списак аутора (веза) ...

*Astrocyte

Verkhratsky, A; Orkand, RK; Kettenmann, H (January 1998). "Glial calcium: homeostasis and signaling function". Physiological ... Calcium evidence. Calcium waves appear only if a certain concentration of neurotransmitter is exceeded. [28][29][30] ... In this chronic signaling pathway, p38 is activated as a result of IL-1β signaling, and there is a presence of chemokines that ... Mechanisms of calcium wave propagation include diffusion of calcium ions and IP3 through gap junctions and extracellular ATP ...

*Spiral wave

Verkhratsky A, Orkand RK, Kettenmann H (1998). "Glial calcium: homeostasis and signaling function". Physiol. Rev. 78: 99-141. ... Xenopus oocyte calcium waves, and glial calcium waves in cortical tissue culture. Reproduzir conteúdo Winfree AT. (2001). The ... Lechleiter J, Girard S, Peralta E, Clapham D (1991). "Spiral calcium wave propagation and annihilation in Xenopus laevis ...

*STIM1

Soboloff J, Rothberg BS, Madesh M, Gill DL (Sep 2012). "STIM proteins: dynamic calcium signal transducers". Nature Reviews ... In 2005, it was discovered that STIM1 functions as a calcium sensor in the endoplasmic reticulum. Upon activation of the IP3 ... STIM1-mediated calcium entry is required for thrombin-induced disassembly of VE-cadherin adherens junctions. 2- ... STIM1 activates the "store-operated" ORAI1 calcium ion channels in the plasma membrane, via intracellular STIM1 movement, ...

*LiMETER

Soboloff, Jonathan; Rothberg, Brad S.; Madesh, Muniswamy; Gill, Donald L. (2012-01-01). "STIM proteins: dynamic calcium signal ... STIM1 is an ER-resident calcium sensor protein responsible for sensing calcium changes in internal calcium stores and ... "Molecular Basis of Calcium Signaling in Lymphocytes: STIM and ORAI". Annual Review of Immunology. 28 (1): 491-533. doi:10.1146/ ... Store-Operated Calcium Channels. 71. Academic Press. pp. 33-58. doi:10.1016/b978-0-12-407870-3.00002-0. Hogan, Patrick G.; ...

*Inositol monophosphatase

"Inositol trisphosphate and calcium signalling mechanisms". Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1793 ... IP3 is also a second messenger which activates receptors on the endoplasmic reticulum to release calcium ion stores into the ... Furthermore, not only is PIP2 a precursor to several signaling molecules, it can be phosphorylated at the 3' position to become ... Because of IMPase's crucial role in this signaling pathway, it is a potential drug target for inhibition and modulation. There ...

*Parvalbumin

... is a small, stable protein containing EF-hand type calcium binding sites. It is involved in calcium signaling. ... Calcium binding proteins like parvalbumin play a role in many physiological processes, namely cell-cycle regulation, second ... Other calcium-binding protein markers are calretinin (most abundant subtype in DLPFC, about 50%) and calbindin. Interneurons ... Play media Parvalbumin is a calcium-binding albumin protein with low molecular weight (typically 9-11 kDa). It has three EF ...

*Soma (biology)

Bazargani, N; Attwell, D (February 2016). "Astrocyte calcium signaling: the third wave". Nature Neuroscience. 19 (2): 182-9. ... A current theory of how such survival signals are sent from axon endings to the soma includes the idea that NGF receptors are ... 2004). "Trafficking the NGF signal: implications for normal and degenerating neurons". Prog. Brain Res. 146: 3-23. doi:10.1016/ ... and this produces a signal that must be transported up the length of the axon to the nucleus. ...

*N-myristoyltransferase 1

Kobayashi M, Takamatsu K, Saitoh S, Noguchi T (1993). "Myristoylation of hippocalcin is linked to its calcium-dependent ... formation can occur if the matrix domain of human immunodeficiency virus type 1 Gag is substituted by a myristylation signal". ...

*Apoptosis

"Oxidative Stress-Induced Caspases are Regulated in Human Myeloid HL-60 Cells by Calcium Signal". Current Signal Transduction ... Overview of TNF (left) and Fas (right) signalling in apoptosis, an example of direct signal transduction. ... "Role of Calcium Signals on Hydrogen Peroxide-Induced Apoptosis in Human Myeloid HL-60 Cells". International Journal of ... The fas receptor (First apoptosis signal) - (also known as Apo-1 or CD95) is a transmembrane protein of the TNF family which ...
Background: Hypertensive cardiomyopathy or pathophysiological changes in myocardial structure and function caused by hypertension is a growing clinical problem due to the ageing population and a lack of curative therapies. The onset of the disease is often clinically silent, progressing over time to therapy-resistant symptomatic forms. Existing therapeutic concepts are, therefore, symptom-oriented and tailored for advanced stages of cardiac remodeling. Understanding molecular processes driving early hypertension-induced changes may improve diagnosis and treatment options.. Recent evidence positions changes in Ca2+ cycling as an early promoter of cardiac remodeling via Ca2+-mediated regulation of transcription. The enzyme Ca2+/calmodulin-dependent protein kinase II (CaMKII) has a central role in this process, as it can translate fine changes in Ca2+ fluxes into altered gene expression. However, the specific regulation of this so-called excitation-transcription coupling in hypertensive ...
One example of such an instability is "alternans", which at the cellular level, is characterized by a beat-to-beat alternation in membrane potential and intracellular calcium dynamics. Alternans, which manifests on the surface electrocardiogram as T-wave alternans, is a putative trigger of some types of reentrant arrhythmias. Two possible mechanisms have been proposed for alternans - either transmembrane ionic currents or intracellular calcium dynamics fail to cycle completely during one beat, due to insufficient time, leading to the beat-to-beat alternations characteristic of alternans. Importantly, because the voltage and intracellular calcium dynamics are bidirectionally coupled, alternans in one system will lead to secondary alternans in the other. Because of this coupling it is difficult to determine which mechanism is the main source of the instability. In our laboratory, we attempt to disentangle the contributions of voltage and calcium dynamics leading to cellular alternans via a hybrid ...
One challenge for genetic approaches aimed at studying biological processes is the difficulty of identifying specific functions for broadly acting cell biological pathways. Here, we complement classical genetics with a chemical approach to disrupt polymerized microtubules at a specific time in development. Complete microtubule loss leads to lethality and defects in mitosis, but our experiments took advantage of the fact that late embryogenesis, the time at which asymmetric AWC identities are determined, is a time when little cell division occurs. Using a combination of genetics and drug treatment, we have linked microtubule-dependent localization of calcium-regulated signaling proteins, including UNC-43/CaMKII, TIR-1/SARM adaptor and NSY-1/ASK1 MAPKKK to genetic control of neuronal asymmetry in C. elegans. We also identified the requirement of microtubule-dependent kinesin motor gene unc-104/kif1a in this process.. Our results suggest that microtubule-dependent and unc-104-dependent localization ...
One challenge for genetic approaches aimed at studying biological processes is the difficulty of identifying specific functions for broadly acting cell biological pathways. Here, we complement classical genetics with a chemical approach to disrupt polymerized microtubules at a specific time in development. Complete microtubule loss leads to lethality and defects in mitosis, but our experiments took advantage of the fact that late embryogenesis, the time at which asymmetric AWC identities are determined, is a time when little cell division occurs. Using a combination of genetics and drug treatment, we have linked microtubule-dependent localization of calcium-regulated signaling proteins, including UNC-43/CaMKII, TIR-1/SARM adaptor and NSY-1/ASK1 MAPKKK to genetic control of neuronal asymmetry in C. elegans. We also identified the requirement of microtubule-dependent kinesin motor gene unc-104/kif1a in this process.. Our results suggest that microtubule-dependent and unc-104-dependent localization ...
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WHY WE NEED CALCIUM. By Troy Francis. Calcium is one nutrient that is sometimes overlooked. However, it is one of the most important nutrients your body needs. Calcium plays an important part in body functions and some development. Knowing how much calcium you need daily and where to get it from can ensure that you will lead a healthier life and live longer. What does Calcium do for us! Well, calcium does many things for your body. Everyone knows calcium is great for the bones. It also plays a role in keeping your muscles and nerves working properly. It also helps blood clot and keeps your heart functioning properly. Lacking calcium in your diet can greatly affect your health for years to come. When your body does not get enough calcium it begins to take calcium from the bones. When this occurs, the bones become deficient and problems can start such as osteoporosis. Osteoporosis is a disease that mostly affects older people. Osteoporosis is a disease where the bones get thin and brittle. However ...
Calcium has become the latest double-edged swords in the supplement world.. People want to take calcium for its osteoporosis prevention benefit, but then learn about possible associated cardiovascular disease risks. This usually leaves the consumer confused as to whether the risk is worth the benefit.. To answer the question about whether or not to take calcium, it is first it important to understand the role calcium in our body. Calcium is essential in a variety of physiological functions in our body, in addition to the structural function in our bones. Calcium is a signal molecule for a variety of cellular processes including nerve conduction, muscle contraction, glycogen metabolism and cardiac function. Without calcium, we would not be able to relay signals in our heart or muscles, we wouldnt be able to contract our muscles and our skeleton would not keep us upright.. What is the connection with calcium and heart disease? Some recent research had correlated an increased risk of heart disease ...
Calcium waves are propagated among islands of UMR cells. Calcium waves were induced in a subconfluent monolayer of fluo-3-loaded UMR cells. The outline of c
The latest Perspectives in General Physiology series introduces the newest technologies in the field of calcium signaling, which plays a central role in many cellular processes.
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Part No. 486668-K. Specially formulated reagent works in conjunction with current eXact® Strip Micro Calcium Hardness (486629). This kit allows for detection of Calcium Hardness 730 - 1500 ppm (as CaCO3) without the need for a dilution kit. Bulk bottle of 50 each: eXact® Strip Micro Calcium Hardness #486629 & eXact® Reagent CA Ultra-High #486668.. Range: 730-1500 ppm (as CaCO3) = 292 - 519 ppm (as Ca+2). ...
Q. Since a woman is supposed to have 1,000 milligrams of calcium a day, why dont the calcium tablets contain 500 mg so she can take two a day if she gets little calcium in her diet? By taking two
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It also has many minerals in it such as calcium.,Nutrisystem For Diabetics For people who higher sugar level chew 3.This is the only program I have been able to stick to and see results and always find myself coming back to it.Everything I tried may not have been to my taste but still was edible.There were different sale by dates on the food packs but there was nothing out of date.My husband and I were working different shifts so when he was off we went out to dinner.Back Electrode, Comp-166164370, DC-prod-dal1, ENV-prod-a, PROF-PROD, VER-19.25.2-rc-2, SHA-ed1d03b7cb5d8212be4a79c2eebd1ea264f02889, CID- Be the first to save.Buy Nutrisystem Everyday 5 Day Weight Loss Kit at Walmart.com.Research shows that the calcium found in dairy numerous help to collapse fat ...
Calcium list and information including what is Calcium, health benefits and usage indications. Find articles and product list for other top low-carb products, fat-burners, nutrition bars and shakes.
Calcium list and information including what is Calcium, health benefits and usage indications. Find articles and product list for other top low-carb products, fat-burners, nutrition bars and shakes.
Calcium is essential for building strong bones and teeth which we must get it from the foods we eat and drink. Find out more about calcium Waitrose
Calcium is essential for building strong bones and teeth which we must get it from the foods we eat and drink. Find out more about calcium Waitrose
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Calcium is an element is vital for the health of many living things, and has a range of industrial uses. Calcium is never found...
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Elutit Calcium is a medicine available in a number of countries worldwide. A list of US medications equivalent to Elutit Calcium is available on the Drugs.com website.
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[101 Pages Report] Check for Discount on Global Anhydrous Dibasic Calcium Phospate Market Professional Survey Report 2017 report by QYResearch Group. This report studies Anhydrous Dibasic Calcium Phospate in Global market,...
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Cu plumping is getting pretty clogged up with calcium buildup otherwise the pipes are in good shape. I have remove and replaced a few sections for inspection and the test sections were like new after the deposits were removed. IS there a way to chemically or by other means to unclog them. I
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Recent research shows that taking your calcium twice daily instead of all at once may be optimal. Watch this video to find out why. Or read it on the AlgaeCa…Video Rating: 0 / 5. ...
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Your parents were right to make you drink milk when you were little. Its loaded with calcium, a mineral vital for building strong bones and teeth.
Your parents were right to make you drink milk when you were little. Its loaded with calcium, a mineral vital for building strong bones and teeth.
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Покупаю этот кальций уже второй год подряд для дочери, беру комплекс от Solgar - мультивитамины + кальций. Внутри банки жевательные кубики, мягкие и вкусные, дочь не пропускает ни дня . Кальций обязательно необходим детям и подросткам, именно в детском возрасте создается запас кальция на всю жизнь и закладывается прочность костей. Плюс, здесь есть витамин Д, он повышает всасываемость кальция в кишечнике. Отличный комплекс, отличный производитель. Я рекомендую к покупке! Дозировка: для детей от 2-х лет 2 кубика в день, для детей 4 года и старше - 4 кубика в ...
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Calcium signaling is known to be associated with cytokinesis; however, the detailed spatio-temporal pattern of calcium dynamics has remained unclear. We have studied changes of intracellular free calcium in cleavage-stage Xenopus embryos using fluorescent calcium indicator dyes, mainly Calcium Green-1. Cleavage formation was followed by calcium transients that localized to cleavage furrows and propagated along the furrows as calcium waves. The calcium transients at the cleavage furrows were observed at each cleavage furrow at least until blastula stage. The velocity of the calcium waves at the first cleavage furrow was approximately 3 microns/s, which was much slower than that associated with fertilization/egg activation. These calcium waves traveled only along the cleavage furrows and not in the direction orthogonal to the furrows. These observations imply that there exists an intracellular calcium-releasing activity specifically associated with cleavage furrows. The calcium waves occurred in ...
1b shows that there was a general decrease also in 495 nm signal as the experiment progressed. This means that there was no change in the 405/495 ratio with time (Fig. 1c), which correctly reflects that there was no change in [Ca2+]i. D. Bruton et al. non-ratiometric indicators can result in completely erroneous conclusions. It should, however, be noted that not all problems are avoided by using ratiometric indicators. For instance, excessive light exposure can lead to qualitatively altered properties of the indicator, which cannot be corrected for by ratios. Neuron 57:536-545 44. Bender KJ, Trussell LO (2009) Axon initial segment Ca2+ channels influence action potential generation and timing. Neuron 61:259-271 45. Bers DM (2008) Calcium cycling and signaling in cardiac myocytes. Annu Rev Physiol 70:23-49 46. Dolmetsch R (2003) Excitation-transcription coupling: signaling by ion channels to the nucleus. Sci STKE 2003:PE4 47. Arnold DB, Heintz N (1997) A calcium responsive element that regulates ...
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Calcium imaging is a scientific technique usually carried out in research which is designed to show the calcium (Ca2+) status of an isolated cell, tissue or medium. Calcium imaging techniques take advantage of so-called calcium indicators, fluorescent molecules that can respond to the binding of Ca2+ ions by changing their fluorescence properties. Two main classes of calcium indicators exist: chemical indicators and genetically encoded calcium indicators (GECI). Calcium imaging can be used to optically probe intracellular calcium in living animals. This technique has allowed studies of calcium signalling in a wide variety of cell types and neuronal activity in hundreds of neurons and glial cells within neuronal circuits . Chemical indicators are small molecules that can chelate calcium ions. All these molecules are based on an EGTA homologue called BAPTA, with high selectivity for calcium (Ca2+) ions versus magnesium (Mg2+) ions. This group of indicators includes fura-2, indo-1, fluo-3, fluo-4, ...
Calcium encoding (also referred to as Ca2+ encoding or calcium information processing) is an intracellular signaling pathway used by many cells to transfer, process and encode external information detected by the cell. In cell physiology, external information is often converted into intracellular calcium dynamics. The concept of calcium encoding explains how Ca2+ ions act as intracellular messengers, relaying information within cells to regulate their activity. Given the ubiquity of Ca2+ ions in cell physiology, Ca2+ encoding has also been suggested as a potential tool to characterize cell physiology in health and disease. The mathematical bases of Ca2+ encoding have been pioneered by work of Joel Keizer and Hans G. Othmer on calcium modeling in the 1990s and more recently they have been revisited by Eshel Ben-Jacob, Herbert Levine and co-workers. Although elevations of Ca2+ are necessary for it to act as a signal, prolonged increases of the concentration of Ca2+ in the cytoplasm can be lethal ...
Plant hormones, light receptors, pathogens, and abiotic signals trigger elevations in the cytosolic calcium concentration, which mediate physiological and developmental responses. Recent studies are reviewed here that reveal how specific genetic mutations impair or modify stimulus-induced calcium elevations in plant cells. These studies provide genetic evidence for the importance of calcium as a second messenger in plant signal transduction. A fundamental question arises: How can different stimuli use the same second messenger, calcium, to mediate different responses? Recent research and models are reviewed that suggest that several important mechanisms contribute to specificity in calcium signaling in plant cells. These mechanisms include (i) activation of different calcium channels in the plasma membrane and organellar membranes, (ii) stimulus-specific calcium oscillation parameters, (iii) cell type-specific responses, and (iv) intracellular localization of calcium gradients and calcium ...
TY - JOUR. T1 - STIM1 calcium sensor is required for activation of the phagocyte oxidase during in flammation and host defense. AU - Zhang, Hong. AU - Clemens, Regina A.. AU - Liu, Fengchun. AU - Hu, Yongmei. AU - Baba, Yoshihiro. AU - Theodore, Pierre. AU - Kurosaki, Tomohiro. AU - Lowell, Clifford A.. PY - 2014/4/3. Y1 - 2014/4/3. N2 - The stromal-interactingmolecule 1 (STIM1) is a potent sensor of intracellular calcium, which in turn regulates entry of external calcium through plasmamembrane channels to affect immune cell activation. Although the contribution of STIM1 to calcium signaling in lymphocytes has been well studied, the role of this protein in neutrophil-mediated inflammation and host defense is unknown. We report that STIM1-deficient murine neutrophils show loss of store-operated calcium entry (SOCE) in response to both soluble ligands that activate G-proteins as well as Fcγ-receptor or integrin ligation that activates tyrosine kinase signaling. This results in modest defects in ...
This paper utilizes the COMSOL Multiphysics® general form PDE interface and MATLAB® to model stochastic calcium waves in a sarcomere (basic unit of a heart cell). The model we present here shows the evolution of waves generated from calcium being released stochastically from sites modeled as point sources. The release sites are distributed on z-disc (planes) in a hexagonal pattern, and their opening allows calcium to diffuse and interact with different species of buffers. The release sites are sensitive to calcium levels and after opening and releasing calcium, undergo a refractory period during which they stay closed. The simulations obtained over a sarcomere domain shows individual stochastic releases of calcium self-organizing into propagating waves. ...
Taking too much calcium will actually cause you to absorb less of it. Its the bodys natural way of protecting itself. Take no more than 500 mg calcium at once. Excessive sodium, caffeine and alcohol intake can increase calcium loss, so its important to replace the calcium (and other minerals) you might be losing in these cases. People living in areas with high levels of calcium in the drinking water, or people who consume more calcium from their diet, may not need to supplement as much calcium. Oxalate and phytate compounds found in certain vegetables and grains reduce calcium absorption. If youre trying to get your calcium from vegetables in a non-dairy, non-supplemented diet, you may have to consume a lot more calcium from food than you would from milk or from a supplement.. Thats enough info for one sitting. Stay tuned for part 2 where we will examine the different forms of calcium used in calcium supplements and discover whats what and whats best!. Image by © 2011 Kalinovsky Dmitry ...
Important element in road towards development of new drugs for neurodegenerative diseases All living cells keep their cellular calcium concentration at a very low level. Since a small increase in calcium can affect many critical cellular functions (an elevated calcium concentration over an extended period can induce cell death), powerful cellular mechanisms ensure that calcium concentration quickly returns to its low level.. It is known that impairments of cellular calcium regulation underlie almost all neurodegenerative diseases. For example, age-related loss of calcium regulation was shown to promote cell vulnerability in Alzheimers disease.. In a study recently published in the Journal of Neuroscience, Hebrew University of Jerusalem researchers, along with others from Israel and the US, presented their findings of a previously undescribed cellular mechanism which is essential for keeping cellular calcium concentration low. This mechanism operates together with other already characterized ...
Mouse monoclonal Stromal interaction molecule 1 antibody validated for WB, IP, IHC, ICC, Flow Cyt, ICC/IF and tested in Human. Referenced in 2 publications and…
Mouse monoclonal Stromal interaction molecule 1 antibody [CDN3H4] validated for WB, IP and tested in Mouse and Rat. Referenced in 1 publication. Immunogen…
Stromal interaction molecule 1兔单克隆抗体[EPR3414](ab108994)可与小鼠, 大鼠, 人样本反应并经WB, IP, IHC实验严格验证。中国75%以上现货。
To unravel the evolutionarily conserved genetic network underlying energy homeostasis, we performed a systematic in vivo gene knockdown screen in D...
Dendritic spines compartmentalize synaptically-evoked biochemical signals. The authors show that electrical compartmentalization provided by a spine endows the associated synapse with additional modes of calcium signaling by shaping the kinetics of synaptic calcium currents.
These different types of calcium are used for their own special properties. The use of these calcium is safe, and most likely a healthy choice. By choosing to use these you are enabling your body to function properly and correctly. The three different types of calcium all have an important function and are used to boost the natural calcium in your body. These types of calcium can be found in the foods you eat, the drinks you drink, and the dietary supplements you use. Each of these has been found to improve your blood system, your muscles your bones, and your teeth. These are in the simplest form, the same as calcium with the exception that these actually help calcium do it what it needs to do in the body ...
Calcium is the mineral that our body uses in the largest quantities. Everyone knows Calcium is required to build bones and teeth but Calcium does so much more. It promotes blood clotting & healing. It is involved in regulating metabolism and in particular, the metabolism of fats. It is necessary to maintain the proper pH balance in the body, and Calcium helps regulate the blood pressure, leading to better cardiovascular health.*. Unfortunately, Calcium is a mineral of which most Americans do not get enough. While vitamin D can assist in the utilization of Calcium, it helps to begin with a form of calcium that is readily assimilable by the body. Our liquid ionic Calcium supplement is the most bio-available form you can get.*. ...
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... typically results from the intake of bad form of calcium or from your body not being able to utilise calcium properly, due to thyroid weakness, stress, acidosis, adrenal gland weakness, etc. Often calcium at toxic levels is at the same time combined with calcium deficiency, which seems contradictory but is not. This article discusses the good and bad types of calcium...
Dr. Lupo, I have now had 5 tests this year. Calcium 10.8 Ionized calcium 1.37 H (1.17-1.32) Calcium 10.2 PTH 17.7 Ionized Calcium 1.37 H Calcium 10.2 PTH 22.4 Ionized Calcium 1.37 H ...
Caffeine-induced calcium oscillations in heavy-sarcoplasmic-reticulum vesicles from rabbit skeletal muscle.: Heavy-sarcoplasmic-reticulum vesicles from rabbit s
Li, Ting and Yan, An and Bhatia, Neha et al. (2019) Calcium signals are necessary to establish auxin transporter polarity in a plant stem cell niche. Nature Communications, 10 . Art. No. 726. ISSN 2041-1723. PMCID PMC6374474. https://resolver.caltech.edu/CaltechAUTHORS:20190213-155805773 ...
Complete information for STIM2 gene (Protein Coding), Stromal Interaction Molecule 2, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
Its hard for us to consume a sufficient amount of calcium because its so easily depleted from our bodies. Factors that contribute to calcium depletion include age, stress, hormonal imbalances, environmental pollutants, nutrient depleted farmlands and, most of all, a diet of highly refined processed foods.. Picture a full cup with a hole in the bottom. Traditional calcium supplements act offensively, trying to keep the cup full. Progressive products not only work to meet your calcium needs, they also work defensively against the depletion of our existing calcium stores, patching the "leaky cup" so you can get the greatest possible benefit.. Age and Gender Specific ...
Its hard for us to consume a sufficient amount of calcium because its so easily depleted from our bodies. Factors that contribute to calcium depletion include age, stress, hormonal imbalances, environmental pollutants, nutrient depleted farmlands and, most of all, a diet of highly refined processed foods.. Picture a full cup with a hole in the bottom. Traditional calcium supplements act offensively, trying to keep the cup full. Progressive products not only work to meet your calcium needs, they also work defensively against the depletion of our existing calcium stores, patching the "leaky cup" so you can get the greatest possible benefit.. Age and Gender Specific ...
Learn more about Calcium at St. Marks Hospital Supplement Forms/Alternate Names Bonemeal Calcium Aspartate Calcium Carbonate Calcium Chelate Calcium...
Calcium in living cells by M. J. Whitaker; 1 edition; First published in 2010; Subjects: Calcium Channels, Cultured Cells, SCIENCE / Life Sciences / Anatomy & Physiology, Cells, Signal Transduction, Humans, Calcium, Cellular signal transduction, Intracellular calcium, Metabolism
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The IUPHAR/BPS Guide to Pharmacology. tumor associated calcium signal transducer 2 - Tumour-associated proteins. Detailed annotation on the structure, function, physiology, pharmacology and clinical relevance of drug targets.
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Not having enough calcium can cause many health problems. Calcium insufficiency also causes weak bones and tooth decay. This is because almost all calcium is stored in bones and teeth.
Because most kids who are age 8 and older arent getting enough calcium, the American Academy of Pediatrics (AAP) is reminding parents to make sure kids get the calcium and physical activity they need to grow strong bones, especially during the teen years, when bone growth peaks. Pediatrician Dr. Lanna McClain joins us to stress the importance of calcium.
Find the best calcium supplements, best sources of calcium, foods and natural sources of calcium and recommended daily intake. All testing done independently by ConsumerLab.com.
Calcium bis(cyclohexylsulphamate) 139-06-0 NMR spectrum, Calcium bis(cyclohexylsulphamate) H-NMR spectral analysis, Calcium bis(cyclohexylsulphamate) C-NMR spectral analysis ect.
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I am in Dallas, TX and we have hard water. My calcium is a bit over 400 right now. The pool is around 2 years old. I do get deposites on my waterfall and on the tile splash. A) is this level dangerous to my equipment/pipes/etc B) How to get rid of the deposits C) How to decrease the Calcium levels? Thanks for the help! Mo
Molecular Movies for Calcium Ion Imaging. New Femtosecond Raman Technology Reveals Chemistry in Action Molecular Movies for Calcium Ion Imaging - New Femtosecond Raman Technology Reveals Chemistry in
First of all, 80% of all SCA deaths happen to people who have serious cardiac disease, so it has nothing to do with Ca in the blood. If you have one tooth in your head, you probably have enough Ca to take care of all your hearts calcium needs. We have Ca in every cell of our body, and most of it is stored in our bones. Although I could not read the study without paying $35, I suspect the Mayo researchers were just collecting data, and noticed this marker in a modest number of patients. They claimed this finding should not be taken too seriously. Usually, low or high blood calcium is the result of some other underlying medical problem, and either one can cause heart rhythm failures, for one thing ...
Calcium is good for your bones and teeth as well as essential to the workings of your nervous system, muscle contractions, and blood vessel expansion. Determining how to eat more calcium can allow you to lead the healthy lifestyle you have always wanted.
Calcium content and RDA percentage, per serving and per 100g, in 7 types of figs. The amount of Calcium is 162 mg to 26 mg per 100g, in figs.
Yes, our soya products are a source of calcium, just like dairy. Calcium contributes to normal muscle function, the maintenance of normal te...
Calcium is an important mineral that does more than help you build bones. Find out why you need calcium with these tips from Food Network.
Calcium is an essential mineral. Your body needs calcium to build and maintain strong bones and teeth, as well as for cell signaling, heart and muscle...
|p|Lifestream Natural Calcium for your bones, teeth and nails.|/p| |p|Calcium is used by almost every cell in the body including the heart and nerves. It is an important component of a healthy diet. Although we imagine our bones are permanent, they are ac
It is common knowledge that calcium plays a vital role in bone health, but the mechanisms that use calcium at a cellular level are not as well known. In...
BioAssay record AID 865964 submitted by ChEMBL: Open TG-GATES: Regimen: Single; Time: 24 hr; Dose: High; Route: Gavage | Dataset: Biochemistry; Assay: CALCIUM (Calcium); Study_ID: 247/16.
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Calcium in the vegan diet. 101 milligrams in 1 cup raw chopped plus. Top 10 Foods Highest In Calcium Hard drinking water may have moderate health benefits but
Answer to Calcium Build Up of the Eye I know as of my experience calcium build up behind the eye will cause the eye to be very sore, red, watery plus from time to time tickly ...
Information from WorldCat about Calcium Primary School in Calcium, New York, such as address, phone, catalog search and newest items.
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If you have sarcoidosis, consult your doctor before taking calcium. This eMedTV article lists other warnings and precautions concerning the safety of calcium, including other conditions you should tell your doctor about before taking the supplement.
16000 PH 7.2 Chlorine 7.5 Calcium 1100 Alkalinity 120 CYA 80 Should I be concerned about calcium being so high? Our in coming water is 400. Any suggestions?
A calcium signal controls whether immune cells can use the nutrients needed to fuel their multiplication into a cellular army designed to fight invading viruses.
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Calcium signaling is essential for the differentiation of many cell types, including skeletal muscle cells, but its mechanisms remain elusive. Here we demonstrate a crucial role for nicotinic acid adenine dinucleotide phosphate (NAADP) signaling in skeletal muscle differentiation. Although the inositol trisphosphate pathway may have a partial role to play in this process, the ryanodine signaling cascade is not involved. In both skeletal muscle precursors and C2C12, cells interfering with NAADP signaling prevented differentiation, whereas promoting NAADP signaling potentiated differentiation. Moreover, siRNA knockdown of two-pore channels, the target of NAADP, attenuated differentiation. The data presented here strongly suggest that in myoblasts, NAADP acts at acidic organelles on the recently discovered two-pore channels to promote differentiation.
The TRPC (transient receptor potential canonical) proteins are activated in response to agonist-stimulated PIP2 (phosphatidylinositol 4,5-bisphosphate) hydrolysis and have been suggested as candidate components of the elusive SOC (store-operated calcium channel). TRPC1 is currently the strongest candidate component of SOC. Endogenous TRPC1 has been shown to contribute to SOCE (store-operated calcium entry) in several different cell types. However, the mechanisms involved in the regulation of TRPC1 and its exact physiological function have yet to be established. Studies from our laboratory and several others have demonstrated that TRPC1 is assembled in a signalling complex with key calcium signalling proteins in functionally specific plasma membrane microdomains. Furthermore, critical interactions between TRPC1 monomers as well as interactions between TRPC1 and other proteins determine the surface expression and function of TRPC1-containing channels. Recent studies have revealed novel regulators ...
By a confocal fluorescence microscope with an argon-ion laser (488 nm) and a He-Cd laser (325 nm) we have studied thapsigargin-induced calcium signals in individual rat basophilic leukaemia (RBL-2H3) cells. In the presence or absence of external calcium ions, thapsigargin-induced calcium signals were transferred to the nucleus as well as to the cytoplasm of RBL-2H3 cells. The calcium signals were generally much stronger in the nucleus than in the cytoplasm. However, some of the RBL-2H3 cells had apparently reduced nuclear calcium signals. They had a basophil-like bilobed (multilobed) nucleus, although most RBL-2H3 cells had a mast-cell-like monolobed nucleus. In the cells with a bilobed nucleus, IgE-receptor-mediated calcium signals were neither transferred to the nucleus nor to the cytoplasm. The results gave a new insight into the understanding of the mechanism of the nuclear calcium signals in RBL-2H3 cells. ...
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Cardiac myocytes express two types of voltage operated calcium currents, a high voltage activated (HVA) L-type, and a low voltage activated (LVA) T-type. Influx of calcium into the cell through the L-type channel is responsible for excitation-contraction coupling in the heart. The T-type calcium current has been associated with growth and differentiation in a number of different cell types. An atrial myocyte cell line (HL-1) that selectively expresses T-type calcium current was employed to show that inhibiting calcium influx through the T-type calcium channel inhibits cellular proliferation. Drug dosage studies demonstrate that the T-type calcium channel responsible for this effect is Cav 3.1. Furthermore, blocking the calcium influx through the T-type calcium channel arrests cells in the G2/M phase of the cell cycle. Interestingly, the proliferative effect of calcium influx through the T-type calcium channel appears to happen in the early G1 phase of the cell cycle ...
The Romans used lime (calcium oxide), clacked lime (calcium hydroxide), and hydraulic cement in construction works. Calcium (Latin calx, meaning "lime") was first isolated in its metallic form by Sir Humphrey Davy in 1808 through the electrolysis of a mixture of calcium oxide and mercury oxide.. Chelated calcium refers to the way in which calcium is chemically combined with another substance. Calcium citrate is an example of such a chelated preparation. Calcium may also be combined with other substances to form preparations such as calcium lactate or calcium gluconate. Calcium carbonate can be refined from limestone, natural elements of the earth, or from shell sources, such as oyster. Shell sources are often described on the label as a "natural" source. Calcium carbonate from oyster shells is not "refined" and can contain variable amounts of lead.. Calcium is the most abundant mineral in the human body and has several important functions. More than 99% of total body calcium is stored in the ...
Looking for online definition of Plasma membrane calcium pump isoform 4 in the Medical Dictionary? Plasma membrane calcium pump isoform 4 explanation free. What is Plasma membrane calcium pump isoform 4? Meaning of Plasma membrane calcium pump isoform 4 medical term. What does Plasma membrane calcium pump isoform 4 mean?
Cellular stress responses often involve elevation of cytosolic calcium levels, and this has been suggested to stimulate autophagy. Here, however, we demonstrated that agents that alter intracellular calcium ion homeostasis and induce ER stress-the calcium ionophore A23187 and the sarco/endoplasmic reticulum Ca (2+)-ATPase inhibitor thapsigargin (TG)-potently inhibit autophagy. This anti-autophagic effect occurred under both nutrient-rich and amino acid starvation conditions, and was reflected by a strong reduction in autophagic degradation of long-lived proteins. Furthermore, we found that the calcium-modulating agents inhibited autophagosome biogenesis at a step after the acquisition of WIPI1, but prior to the closure of the autophagosome. The latter was evident from the virtually complete inability of A23187- or TG-treated cells to sequester cytosolic lactate dehydrogenase. Moreover, we observed a decrease in both the number and size of starvation-induced EGFP-LC3 puncta as well as reduced numbers of

Calcium Protein Signaling | SpringerLinkCalcium Protein Signaling | SpringerLink

The Sixth International Symposium on Calcium-Binding Proteins in Health and Disease was held in Nagoya, Japan, July 24-28, 1988 ... Calcium Signaling in Molecular Cell Biology. * Roles of Calcium in the Regulation of Tyrosine Hydroxylase ... Cytoskeleton and Calcium Signaling. * Calcium and Polyphosphoinositide Regulation of Actin Network Structure by Gelsolin ... Protein Phosphatase and Calcium Signaling. * Characterization of the Calmodulin-Binding Domain of Calcineurin Deduced from a ...
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Membrane Dynamics and Calcium Signaling | SpringerLinkMembrane Dynamics and Calcium Signaling | SpringerLink

This book describes the newest discoveries on calcium signaling happening at the cellular and intracellular membranes, often ... calcium signaling calcium transport endoplasmatic reticulum membrane dynamics membrane contact sites microdomains mitochondria ... This book describes the newest discoveries on calcium signaling happening at the cellular and intracellular membranes, often ... the book therefore provides a timely summary on the processes of calcium signaling and related membrane dynamics; it is aimed ...
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Calcium and calcium signalingCalcium and calcium signaling

... * Calcium signaling: an underlying link between cardiac disease and carcinogenesis Authors: ... Syncytium calcium signaling and macrophage function in the heart Macrophages are traditionally viewed as a key component of the ... A temporal examination of calcium signaling in cancer- from tumorigenesis, to immune evasion, and metastasis Although the study ... A superior bright NIR luminescent nanoparticle preparation and indicating calcium signaling detection in cells and small ...
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Local calcium signaling in neurons.  - PubMed - NCBILocal calcium signaling in neurons. - PubMed - NCBI

Several qualitatively different forms of local calcium signaling can be distinguished by the location of open calcium channels ... Local calcium signaling in neurons.. Augustine GJ1, Santamaria F, Tanaka K. ... Local calcium signaling is especially prominent at presynaptic active zones and postsynaptic densities, structures that are ... Similar forms of local calcium signaling may be employed throughout the nervous system, though much remains to be learned about ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/14556712?dopt=Abstract

Ca2+ blinks: Rapid nanoscopic store calcium signaling | PNASCa2+ blinks: Rapid nanoscopic store calcium signaling | PNAS

Perspectives on: Local calcium signaling: Subcellular Ca2+ signaling in the heart: the role of ryanodine receptor sensitivity ... Ca2+ blinks: Rapid nanoscopic store calcium signaling. Didier X. P. Brochet, Dongmei Yang, Alessandro Di Maio, W. Jonathan ... Ca2+ blinks: Rapid nanoscopic store calcium signaling. Didier X. P. Brochet, Dongmei Yang, Alessandro Di Maio, W. Jonathan ... Ca2+ blinks: Rapid nanoscopic store calcium signaling. Didier X. P. Brochet, Dongmei Yang, Alessandro Di Maio, W. Jonathan ...
more infohttps://www.pnas.org/content/102/8/3099?ijkey=b9b9eda345d61a37efe6bac79df4a65da0851e03&keytype2=tf_ipsecsha

Calcium signaling and secretion in cholangiocytes.  - PubMed - NCBICalcium signaling and secretion in cholangiocytes. - PubMed - NCBI

Calcium signaling and secretion in cholangiocytes.. Guerra MT1, Nathanson MH2. ... signaling machinery are altered in a range of cholestatic diseases of the bile ducts. ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed?term=26100660

Calcium Signaling by Md. Shahidul Islam | WaterstonesCalcium Signaling by Md. Shahidul Islam | Waterstones

Buy Calcium Signaling by Md. Shahidul Islam from Waterstones today! Click and Collect from your local Waterstones or get FREE ... Calcium Signaling - Advances in Experimental Medicine and Biology 740 (Hardback). Md. Shahidul Islam (editor) Sign in to write ... Calcium signaling contains a unique selection of chapters that cover a wide range of contemporary topics in this ubiquitous and ... If you want to read about calcium signaling in different mammalian cells, oocytes, Zebrafishes, and even in plants, in one and ...
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Critical Calcium Levels | Science SignalingCritical Calcium Levels | Science Signaling

These results were interpreted that the amount of ER calcium per se was not crucial, but a signal generated from the released ... However, cells overexpressing the ER calcium-buffering protein calreticulin, which allows increased calcium loading in the ER ... which prevents the release of a sufficiently high calcium signal from the ER upon ceramide exposure. This model is consistent ... Your Name) has forwarded a page to you from Science Signaling Message Body. (Your Name) thought you would like to see this page ...
more infohttps://stke.sciencemag.org/content/2001/86/tw10.abstract

Enhancing Calcium Signaling | Science SignalingEnhancing Calcium Signaling | Science Signaling

P. Tosetti, N. Pathak, M. H. Jacob, K. Dunlap, RGS3 mediates a calcium-dependent termination of G protein signaling in sensory ... Signaling by G proteins is terminated by the GTPase activity of the α subunit. Regulators of G protein signaling (RGS) ... Your Name) has forwarded a page to you from Science Signaling Message Body. (Your Name) thought you would like to see this page ... Thank you for your interest in spreading the word about Science Signaling. ...
more infohttps://stke.sciencemag.org/content/2003/188/tw236

Calcium Signaling - Hill Lab - UT Southwestern Medical CenterCalcium Signaling - Hill Lab - UT Southwestern Medical Center

Calcium Signaling Calcium signaling diagram. It is widely agreed that derangements in intracellular Ca2+ homeostasis are ...
more infohttps://www.utsouthwestern.edu/labs/hill/research/calcium.html

cAMP / Calcium Signaling - QIAGENcAMP / Calcium Signaling - QIAGEN

... and signal transduction pathway activation. Solutions optimized for cAMP/calcium signaling studies include PCR array, miRNA, ... cAMP Calcium Signaling PathwayFinder RT2 Profiler PCR Array The Rat cAMP/Ca2+ PathwayFinder RT² Profiler PCR Array contains 84 ... cAMP Calcium Signaling PathwayFinder RT2 Profiler PCR Array The Human cAMP/Ca2+ PathwayFinder RT² Profiler PCR Array contains ... cAMP Calcium Signaling PathwayFinder RT2 Profiler PCR Array The Mouse cAMP/Ca2+ PathwayFinder RT² Profiler PCR Array contains ...
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cAMP / Calcium Signaling - QIAGENcAMP / Calcium Signaling - QIAGEN

... and signal transduction pathway activation. Solutions optimized for cAMP/calcium signaling studies include PCR array, miRNA, ... cAMP Calcium Signaling PathwayFinder RT2 Profiler PCR Array The Rat cAMP/Ca2+ PathwayFinder RT² Profiler PCR Array contains 84 ... cAMP Calcium Signaling PathwayFinder RT2 Profiler PCR Array The Human cAMP/Ca2+ PathwayFinder RT² Profiler PCR Array contains ... cAMP Calcium Signaling PathwayFinder RT2 Profiler PCR Array The Mouse cAMP/Ca2+ PathwayFinder RT² Profiler PCR Array contains ...
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Synergy of cAMP and calcium signaling pathways in CFTR regulation | PNASSynergy of cAMP and calcium signaling pathways in CFTR regulation | PNAS

C) Calcium signal followed by cAMP signaling results in additional CFTR activation. (D) cAMP signal stimulates CFTR channel ... Calcium signaling is tightly coupled to calmodulin, a multifunctional intermediate messenger that translates calcium signals to ... including increased calcium signaling. Many investigations have described indirect effects of calcium signaling on CFTR or ... it is not surprising that calcium signal-activated CFTR and CFTR-regulated calcium signaling were recently the targets of many ...
more infohttps://www.pnas.org/content/114/11/E2086

Calcium SignalingCalcium Signaling

CALCIUM SIGNAL GENERATION/MODULATION AND HOMEOSTASIS. Calcium Entry. Voltage-Gated Calcium Channels. William A. Catterall. The ... FUNCTIONAL ASPECTS OF CALCIUM SIGNALING. Proteins Mediating Effects of Calcium. The Diversity of Calcium Sensor Proteins in the ... Calcium Signaling in Cardiac Myocytes. Claire J. Fearnley, H. Llewelyn Roderick, and Martin D. Bootman. Calcium Signaling in ... Calcium in Cell Death and Disease. Apoptosis and Autophagy: Decoding Calcium Signals that Mediate Life or Death. Michael W. ...
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Calcium Signaling
	Calcium Signaling

CALCIUM SIGNAL GENERATION/MODULATION AND HOMEOSTASIS. Calcium Entry. Voltage-Gated Calcium Channels. William A. Catterall. The ... FUNCTIONAL ASPECTS OF CALCIUM SIGNALING. Proteins Mediating Effects of Calcium. The Diversity of Calcium Sensor Proteins in the ... Calcium Signaling in Cardiac Myocytes. Claire J. Fearnley, H. Llewelyn Roderick, and Martin D. Bootman. Calcium Signaling in ... Calcium in Cell Death and Disease. Apoptosis and Autophagy: Decoding Calcium Signals that Mediate Life or Death. Michael W. ...
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Calcium Signaling
	Calcium Signaling

CALCIUM SIGNAL GENERATION/MODULATION AND HOMEOSTASIS. Calcium Entry. Voltage-Gated Calcium Channels. William A. Catterall. The ... FUNCTIONAL ASPECTS OF CALCIUM SIGNALING. Proteins Mediating Effects of Calcium. The Diversity of Calcium Sensor Proteins in the ... Calcium Signaling in Cardiac Myocytes. Claire J. Fearnley, H. Llewelyn Roderick, and Martin D. Bootman. Calcium Signaling in ... Calcium in Cell Death and Disease. Apoptosis and Autophagy: Decoding Calcium Signals that Mediate Life or Death. Michael W. ...
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JCI -
Axial tubule junctions control rapid calcium signaling in atriaJCI - Axial tubule junctions control rapid calcium signaling in atria

Axial tubule junctions control rapid calcium signaling in atria. Sören Brandenburg,1,2 Tobias Kohl,1,2 George S.B. Williams,3 ... Dynamics of calcium sparks and calcium leak in the heart. Biophys J. 2011;101(6):1287-1296.. View this article via: PubMed ... The spatial pattern of atrial cardiomyocyte calcium signalling modulates contraction. J Cell Sci. 2004;117(Pt 26):6327-6337. ... F25, Ca2+ signal onset during -75 to 0 mV depolarization. (N) Latency difference of Ca2+ signal upstroke (dF/dt). n = 15 AMs. * ...
more infohttps://www.jci.org/articles/view/88241

Nociceptin Signaling Involves a Calcium-Based Depolarization in Tetrahymena thermophilaNociceptin Signaling Involves a Calcium-Based Depolarization in Tetrahymena thermophila

... Thomas Lampert,1 Cheryl Nugent,2 John ... Thomas Lampert, Cheryl Nugent, John Weston, Nathanael Braun, and Heather Kuruvilla, "Nociceptin Signaling Involves a Calcium- ...
more infohttps://www.hindawi.com/journals/ijpep/2013/573716/cta/

Calcium level may signal risk of mental decline - ReutersCalcium level may signal risk of mental decline - Reuters

Reuters Health) - In elderly people, higher levels of calcium in the blood are associated with poorer mental function and ... Calcium can pass from the blood stream into the brain, they add, but it has not been clear whether blood calcium levels have ... When the researchers excluded people with abnormally high calcium levels from their analysis, the link between calcium levels ... Higher calcium levels were also tied to faster mental decline over time in the Rotterdam study, but not in the more elderly ...
more infohttps://uk.reuters.com/article/health-calcium-level-dc/calcium-level-may-signal-risk-of-mental-decline-idUKCOL45857320071204?feedType=RSS&feedName=healthNews&utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+reuters%2FUKHealth+%28News+%2F+UK+%2F+Health+%26+Drugs%29

Calcium Signaling in Cardiac Myocytes | Frontiers Research TopicCalcium Signaling in Cardiac Myocytes | Frontiers Research Topic

The importance of calcium signaling extends well beyond this role. For example, Calcium signaling serves to modulate the ... Papers that describe the role of calcium signaling in the heart are welcomed. Papers of diverse form will be considered ... A combination of experimental and computational approaches have been effectively applied to study calcium signaling in the ... The common theme is that they describe calcium signaling in the heart ...
more infohttps://www.frontiersin.org/research-topics/608/calcium-signaling-in-cardiac-myocytes

Regulation of Angiogenic Functions by Angiopoietins through Calcium-Dependent Signaling PathwaysRegulation of Angiogenic Functions by Angiopoietins through Calcium-Dependent Signaling Pathways

... Irene Pafumi,1 Annarita Favia ... Both cytokines were found to elicit intracellular calcium mobilization. Targeting intracellular Ca2+ signaling, antagonizing IP ... This study describes a novel calcium-dependent machinery activated through Angiopoietin-1/2-Tie receptor system in HUVECs ... These results identify a novel calcium-dependent machinery involved in the complex interplay regulating angiogenic processes ...
more infohttps://www.hindawi.com/journals/bmri/2015/965271/abs/

Calcium Signaling Through CatSper Channels in Mammalian Fertilization | CurrikiCalcium Signaling Through CatSper Channels in Mammalian Fertilization | Curriki

Education,NSDL,Fertilization,Physics,NSDL_SetSpec_BEN,Sperm,Calcium,oai:nsdl.org:2200/20110722024500764T,Signaling,Life Science ... Calcium Signaling Through CatSper Channels in Mammalian Fertilization. Website Address:https://www.curriki.org/oer/Calcium- ...
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Calcium Signaling, Second Edition (ebook) by Jr. Putney | 9781420038231Calcium Signaling, Second Edition (ebook) by Jr. Putney | 9781420038231

The first edition of James Putneys Calcium Signaling offered readers a comprehensive view of the fascinating diversity of ... technologies that the new field of calcium signaling employed. And while tha ... download and read Calcium Signaling, Second Edition ebook online in PDF format for iPhone, iPad, Android, Computer and Mobile ... In Calcium Signaling, Second Edition, Putney focuses on those processes that generate calcium signals to compile the first ...
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Brain-vascular interactions and calcium signaling | Frontiers Research TopicBrain-vascular interactions and calcium signaling | Frontiers Research Topic

Changes in calcium ion concentration play a predominant and key signaling role in almost all cells of the central nervous ... Many of these cellular players have been well characterized in terms of calcium signaling but astonishingly little is known ... This Research Topic seeks to bring together contributions that improve our understanding of how calcium signaling impacts on ... influences calcium signaling of its constituent cells. The best known interface is t... ...
more infohttps://www.frontiersin.org/research-topics/2654/brain-vascular-interactions-and-calcium-signaling

Calcium Signaling Research Tools - Intracellular Calcium Signaling | Sigma-AldrichCalcium Signaling Research Tools - Intracellular Calcium Signaling | Sigma-Aldrich

USA Home > Product Directory > Cell Biology > Cell Signaling and Neuroscience > Intracellular Calcium Signaling > Calcium ...
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  • Second, calcium uncaging may not generate a physiologically relevant signal, because it increases calcium to indeterminate levels and independently of GPCR signaling cascades. (jneurosci.org)
  • We hypothesized that in a model of contractile dysfunction following ischemia, a commonly used catecholamine such as dopamine augments cardiomyocyte apoptosis via activation of calcium-dependent signaling cascades. (ahajournals.org)
  • When contractility was increased without elevating [Ca 2+ ] i using ORG 30029, no activation of pro-apoptotic signaling cascades was found. (ahajournals.org)
  • Conclusions Postischemic dopamine treatment of contractile dysfunction activates pro-apoptotic signal cascades, most likely via a calcium-dependent process and mitochondrial damage. (ahajournals.org)
  • We therefore tested the hypothesis that, in a model of postischemic contractile dysfunction, treatment with a commonly used catecholamine such as dopamine leads to increased cytosolic calcium and activation of pro-apoptotic signaling cascades, resulting in apoptotic cell death and hence loss of cardiomyocytes. (ahajournals.org)
  • Signalling cascades mediate changes in gene expression by stimulating the translocation of transcription factors from the cytosol to the nucleus, or by causing the translocation and/or activation of enzymes that regulate the activity of nuclear transcription factors or the structure of chromatin. (biologists.org)
  • 2000) Alteration of stimulus‐specific guard cell calcium oscillations and stomatal closing in Arabidopsis det3 mutant. (els.net)
  • Here, we show in renal epithelial cells that ouabain, in doses causing only partial Na,K-ATPase inhibition, acts as a biological inducer of regular, low-frequency intracellular calcium ([Ca2+](i)) oscillations that elicit activation of the transcription factor, NF-KB. (diva-portal.org)
  • The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. (genome.jp)
  • This mechanism may provide a novel homeostatic circuit in calcium signaling. (rupress.org)
  • Consequently, we report a previously unknown immune subversion mechanism involving HIV-1 exploitation, through its Nef accessory protein, of the interconnectivity among three evolutionarily conserved cellular processes: vesicle traffic, signaling compartmentalization, and the second messenger Ca 2+ . (jimmunol.org)
  • This approach has allowed us to separate the Ca 2+ -conducting properties of the LTC from its signaling properties and has provided insight into the mechanism by which voltage-gated channels regulate gene expression. (sciencemag.org)
  • Study authors say their findings define a mechanism for regulating calcium signaling that has never been recognized before and should be of great help to the thousands of scientists who study the extremely important role of calcium signaling in health and disease. (healthcanal.com)
  • If you want to read about calcium signaling in different mammalian cells, oocytes, Zebrafishes, and even in plants, in one and the same book, then this book will not disappoint you. (waterstones.com)
  • However, cells overexpressing the ER calcium-buffering protein calreticulin, which allows increased calcium loading in the ER and subsequent release without increasing free ER calcium, or cells overexpressing the ER calcium pump were more sensitive to ceramide toxicity. (sciencemag.org)
  • Several studies have shown that small but long-term elevations of calcium within nerves and brain cells can kill them, Schram of Leiden University Medical Center and her team point out. (reuters.com)
  • More study is needed, the researchers conclude, to understand the mechanisms by which calcium levels both within and outside nerve cells might contribute to mental decline. (reuters.com)
  • Many of these cellular players have been well characterized in terms of calcium signaling but astonishingly little is known about the consequences and functional role of such signaling at the very sites where these cells interact. (frontiersin.org)
  • This Research Topic seeks to bring together contributions that improve our understanding of how calcium signaling impacts on cellular interactions at the brain-vascular interface, how it alters the function of this interface and how the interface, on its turn, influences calcium signaling of its constituent cells. (frontiersin.org)
  • Calcium signaling in lizard red blood cells. (biomedsearch.com)
  • The ion calcium is a ubiquitous second messenger, present in all eukaryotic cells. (biomedsearch.com)
  • To process this variety of information, the cells display a number of calcium pools, which are capable of mobilization for signaling purposes. (biomedsearch.com)
  • Here we review the calcium signaling on lizards red blood cells, an interesting model that has been receiving an increasing notice recently. (biomedsearch.com)
  • These cells possess a complex machinery to regulate calcium, and display calcium responses to extracellular agonists. (biomedsearch.com)
  • This review will discuss the machinery responsible for Ca 2+ signals in these cells, as well as experimental models used to investigate cholangiocyte Ca 2+ signaling. (mdpi.com)
  • Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. (genome.jp)
  • Tests showed intracellular calcium concentrations in horse red blood cells were 2.3 times less than in human red blood cells. (innovations-report.com)
  • Extracellular calcium concentrations were reversed, with 1.5 times greater calcium concentrations outside cells in equines than in humans. (innovations-report.com)
  • The lower concentrations of calcium within horse cells supported a model proposed by Woods. (innovations-report.com)
  • The Na+/H+-exchanger regulatory factor-2 (NHERF2) anchors the plasma membrane calcium pump isoform PMCA2w/b to the apical membrane in polarized MDCK cells. (mayo.edu)
  • This experiment demonstrates that expression of PMCA2w/b dramatically shortens the duration of the Ca2+ signal compared to control cells that express mainly PMCA4b. (mayo.edu)
  • Here, we patch clamp single motile cilia of mammalian ependymal cells and examine their potential function as a calcium signaling compartment. (elifesciences.org)
  • We measured Ca V 1 voltage-gated calcium channels in ependymal cells, but these channels are not specifically enriched in motile cilia. (elifesciences.org)
  • Intra and inter-cellular calcium signaling is present in all types of cells and body tissues. (nih.gov)
  • In this study, using the calcium ionophore ionomycin and/or PMA on Jurkat T cells, we show that the gene expression program associated with activation of TCR signaling is closely related to specific chromatin landscapes. (jimmunol.org)
  • Many of these elements contain composite NFAT/AP-1 sites, which typically support cooperative binding, thus further reinforcing the need for cooperation between calcium and kinase signaling in the activation of genes in T cells. (jimmunol.org)
  • Study of the activity of PLC product DAG revealed that chemokine-induced signalling was susceptible to inhibition by elevated DAG with S100A9 null cells showing enhanced inhibition by DAG. (open.ac.uk)
  • Calcium signaling controls many responses in RPE cells. (arvojournals.org)
  • Together these results suggest that lysosomal stress can interfere with Ca 2+ signaling through TRPML channels in RPE cells. (arvojournals.org)
  • It has been well established that Ca 2+ signals occurring inside cells affect activities within the nucleus. (biologists.org)
  • First, the intracellular calcium response to histamine was measured in HEK 293 cells using the Fluo-4 Direct™ Calcium Assay. (selectscience.net)
  • To successfully set off disease, rotavirus, a virus that causes severe diarrhea and vomiting in children around the world, must invade cells of the gastrointestinal track and trigger a surge of calcium inside the cells. (ehealthweek2010.org)
  • The calcium spikes can be attenuated by genetically knocking down rotavirus protein NSP4, which is known to disturb calcium balance within cells. (ehealthweek2010.org)
  • Calcium signaling in invertebrate glial cells. (semanticscholar.org)
  • Calcium signaling studies in invertebrate glial cells have been performed mainly in the nervous systems of the medicinal leech (Hirudo medicinalis) and the sphinx moth Manduca sexta. (semanticscholar.org)
  • The rhythmic process is jumpstarted by a spike of calcium in cells in the end of the intestine. (healthcanal.com)
  • This microRNA acts to make the posterior cells different from their neighbors by changing the calcium signaling activity. (healthcanal.com)
  • Beyond their potential therapeutic value, these data provide insights into the intersection of calcium signaling with control of ion homeostasis and the ways in which the local CFTR microdomain organizes itself. (pnas.org)
  • Targeting intracellular Ca 2+ signaling, antagonizing IP 3 with 2-APB or cADPR with 8Br-cADPR, was found to modulate in vitro angiogenic responses to Angiopoietins in a specific way. (hindawi.com)
  • In particular, we focus on the idea that the nucleus has an autonomous Ca 2+ signalling system that can generate its own Ca 2+ transients that modulate processes such as gene transcription. (biologists.org)
  • These results were interpreted that the amount of ER calcium per se was not crucial, but a signal generated from the released ER calcium was an important mediator of ceramide-induced apoptosis. (sciencemag.org)
  • This model is consistent with two simultaneous signals being required to initiate apoptosis, and Bcl-2 blocks one-half of these apoptotic signals. (sciencemag.org)
  • High levels of cytoplasmic calcium can also cause the cell to undergo apoptosis. (wikipedia.org)
  • However, mitochondrial calcium accumulation may also lead to opening of the mitochondrial permeability transition pore with release of pro-apoptotic factors from the intermembrane space followed by "programmed" cell death (apoptosis). (ahajournals.org)
  • and local interactions between adjacent mitochondria allow for the regeneration and spreading of apoptotic signals between mitochondria in some models of apoptosis ( Pacher and Hajnóczky, 2001 ). (rupress.org)
  • Calcium signaling and secretion in cholangiocytes. (nih.gov)
  • Moreover, we discuss how the expression of intracellular Ca(2+) channels might be regulated in cholangiocytes, plus evidence that components of the Ca(2+) signaling machinery are altered in a range of cholestatic diseases of the bile ducts. (nih.gov)
  • These signals take the form of elevations of Ca 2+ with specific spatio‐temporal characteristics which are thought to denote the initial stimulus and mediate an appropriate cellular response. (els.net)
  • A precise measure of the latency of neuronally evoked glial calcium signals is needed to determine whether glial calcium signaling can mediate neurovascular coupling. (jneurosci.org)
  • The indisputable strength of this study is the variety of complementary genetic and imaging techniques that were used to probe whether glial calcium signaling can mediate functional hyperemia. (jneurosci.org)
  • These stimuli induce the formation of Ca 2+ signals within a cell, which are generated through the action of Ca 2+ release and uptake from and into internal cellular stores or the apoplast by the activity of Ca 2+ channels, pumps and exchangers. (els.net)
  • Other biochemical roles of calcium include regulating enzyme activity, permeability of ion channels, activity of ion pumps, and components of the cytoskeleton. (wikipedia.org)
  • Nifedipine exerted maximum inhibition by blocking 30% to 35% of the peak AVP response, indicating the involvement of dihydropyridine-sensitive voltage-dependent calcium channels. (ahajournals.org)
  • These observations indicate that about one third of the AVP-induced constriction of renal resistance vessels is mediated by voltage-dependent L-type calcium channels responsive to the dihydropyridine nifedipine. (ahajournals.org)
  • We conclude that beating of ependymal motile cilia is not tightly regulated by voltage-gated calcium channels, unlike that of well-studied motile cilia and flagella in protists, such as Paramecia and Chlamydomonas . (elifesciences.org)
  • demonstrate that the activity of voltage-gated calcium channels does not control the beating rhythm of the motile cilia in the mouse brain or how quickly the fluid above the cell surface moves. (elifesciences.org)
  • L-type calcium channels selectively signal to the nucleus. (sciencemag.org)
  • As calcium signaling involves such a breadth of technical approaches and a wide range of applications, this work contains invaluable information for established researchers, as well as those graduate students and scientists just beginning to find a direction in cellular calcium signaling. (ebooks.com)
  • The establishment of both mycorrhizal and rhizobial interactions in legumes involves a molecular signal exchange between the plant and its symbiont. (plantphysiol.org)
  • This new edition deals with methods for studying calcium from a variety of perspectives. (ebooks.com)
  • Similar forms of local calcium signaling may be employed throughout the nervous system, though much remains to be learned about the molecular underpinnings of these events. (nih.gov)
  • McCalley AE, Kaja S, Payne AJ, Koulen P. Resveratrol and Calcium Signaling: Molecular Mechanisms and Clinical Relevance. (mdpi.com)
  • This review explores the emerging molecular mechanisms linking Ca 2+ and PI3K signaling in health and disease. (ahajournals.org)
  • The rise and fall of calcium is the molecular clock that times the execution of important processes like the regular and coordinated beating of our hearts. (healthcanal.com)
  • Patients also experience overactivation of inflammatory processes, including increased calcium signaling. (pnas.org)
  • These results identify a novel calcium-dependent machinery involved in the complex interplay regulating angiogenic processes showing that IP 3 - and cADPR-induced Ca 2+ release specifically regulates distinct Angs-mediated angiogenic steps. (hindawi.com)
  • In Calcium Signaling, Second Edition, Putney focuses on those processes that generate calcium signals to compile the first comprehensive exploration of calcium signaling research from a methodological standpoint. (ebooks.com)
  • Calcium (Ca 2+ ) is a versatile second messenger that regulates a number of cellular processes in virtually every type of cell. (mdpi.com)
  • Calcium functions as a universal intracellular messenger, controlling processes as diverse as gene transcription, muscle transcription and cell proliferation, Woods noted. (innovations-report.com)
  • The next step is to find out if this specific microRNA has a similar effect on calcium signaling processes in people as it does in worms. (healthcanal.com)
  • The extracellular space might therefore constitute a much more dynamic Ca 2+ signaling compartment than previously appreciated. (biologists.org)
  • Perhaps it is for this reason that another potentially interesting Ca 2+ signaling compartment, namely the local microenvironment immediately adjacent to the exterior of the cell, has been largely overlooked. (biologists.org)
  • Comprised of five main section, the book covers theoretical and very simple suspension-based fluorimetric assays, specialist measurement systems, measurement of channel activity, measurement of store release, as well as specialist measurement techniques which include targeted probes, using G-protein chimeras to force Ca 2+ signalling for screening, and genetically encoded sensors. (springer.com)
  • To understand the role of this EF-hand-containing complex in Ca 2+ signalling, neutrophils from S100A9 null mice were investigated. (open.ac.uk)
  • However, the reciprocal store depletion signals, which were speculated in various models of spark termination (refs. (pnas.org)
  • The authors suggest that the protection provided by Bcl-2 comes from depletion of the ER calcium stores, which prevents the release of a sufficiently high calcium signal from the ER upon ceramide exposure. (sciencemag.org)
  • The vesicular traffic has emerged as a central player in the assembly of the signaling machinery at the immunological synapse ( 7 ). (jimmunol.org)
  • This led to the proposal that Drosophila photoreceptors do not use the InsP 3 branch of phospholipase C (PLC)-mediated signaling for phototransduction, unlike most other inositol lipid-signaling systems. (jneurosci.org)
  • All the above features of 2-APB, together with very fast penetration into the signaling region inside the cell, make 2-APB an ideal reagent for studies of the involvement of the InsP 3 R in Drosophila phototransduction. (jneurosci.org)
  • These data suggest that Ca 2+ signals arising from InsP 3 Rs suppress autophagy. (open.ac.uk)
  • Interleukin-6 secretion by astrocytes is dynamically regulated by PI3K-mTOR-calcium signaling. (sigmaaldrich.com)
  • Melatonin-induced enterocyte [Ca2+](i) signaling as well as mucosal cell-to-cell communication may be involved in stimulation of duodenal mucosal HCO3- secretion. (diva-portal.org)
  • The Human cAMP/Ca2+ PathwayFinder RT² Profiler PCR Array contains 84 target genes that are responsive to cAMP or calcium ion (Ca2+). (qiagen.com)
  • It associates with RXR and VDR in the nucleus, which stimulates transcription of VDR target genes, resulting in lower intracellular calcium levels. (wikipathways.org)
  • Drosophila phototransduction is an important model system for studies of inositol lipid signaling. (jneurosci.org)
  • Furthermore, the functional specificity of individual CDPKs may be determined by regulations at both transcriptional and posttranslational levels, as well as targeted subcellular compartmentalization, calcium and lipid sensitivity, and substrate recognition. (plantphysiol.org)