Calcium Radioisotopes: Unstable isotopes of calcium that decay or disintegrate emitting radiation. Ca atoms with atomic weights 39, 41, 45, 47, 49, and 50 are radioactive calcium isotopes.Radioisotopes: Isotopes that exhibit radioactivity and undergo radioactive decay. (From Grant & Hackh's Chemical Dictionary, 5th ed & McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Zinc Radioisotopes: Unstable isotopes of zinc that decay or disintegrate emitting radiation. Zn atoms with atomic weights 60-63, 65, 69, 71, and 72 are radioactive zinc isotopes.Calcium Signaling: Signal transduction mechanisms whereby calcium mobilization (from outside the cell or from intracellular storage pools) to the cytoplasm is triggered by external stimuli. Calcium signals are often seen to propagate as waves, oscillations, spikes, sparks, or puffs. The calcium acts as an intracellular messenger by activating calcium-responsive proteins.Radioisotope Dilution Technique: Method for assessing flow through a system by injection of a known quantity of radionuclide into the system and monitoring its concentration over time at a specific point in the system. (From Dorland, 28th ed)Strontium Radioisotopes: Unstable isotopes of strontium that decay or disintegrate spontaneously emitting radiation. Sr 80-83, 85, and 89-95 are radioactive strontium isotopes.Calcium Channels: Voltage-dependent cell membrane glycoproteins selectively permeable to calcium ions. They are categorized as L-, T-, N-, P-, Q-, and R-types based on the activation and inactivation kinetics, ion specificity, and sensitivity to drugs and toxins. The L- and T-types are present throughout the cardiovascular and central nervous systems and the N-, P-, Q-, & R-types are located in neuronal tissue.Iodine Radioisotopes: Unstable isotopes of iodine that decay or disintegrate emitting radiation. I atoms with atomic weights 117-139, except I 127, are radioactive iodine isotopes.Calcium, Dietary: Calcium compounds used as food supplements or in food to supply the body with calcium. Dietary calcium is needed during growth for bone development and for maintenance of skeletal integrity later in life to prevent osteoporosis.Krypton Radioisotopes: Unstable isotopes of krypton that decay or disintegrate emitting radiation. Kr atoms with atomic weights 74-77, 79, 81, 85, and 87-94 are radioactive krypton isotopes.Indium Radioisotopes: Unstable isotopes of indium that decay or disintegrate emitting radiation. In atoms with atomic weights 106-112, 113m, 114, and 116-124 are radioactive indium isotopes.Calcium Isotopes: Stable calcium atoms that have the same atomic number as the element calcium, but differ in atomic weight. Ca-42-44, 46, and 48 are stable calcium isotopes.Sodium Radioisotopes: Unstable isotopes of sodium that decay or disintegrate emitting radiation. Na atoms with atomic weights 20-22 and 24-26 are radioactive sodium isotopes.Radioactivity: The spontaneous transformation of a nuclide into one or more different nuclides, accompanied by either the emission of particles from the nucleus, nuclear capture or ejection of orbital electrons, or fission. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Barium Radioisotopes: Unstable isotopes of barium that decay or disintegrate emitting radiation. Ba atoms with atomic weights 126-129, 131, 133, and 139-143 are radioactive barium isotopes.Radionuclide Imaging: The production of an image obtained by cameras that detect the radioactive emissions of an injected radionuclide as it has distributed differentially throughout tissues in the body. The image obtained from a moving detector is called a scan, while the image obtained from a stationary camera device is called a scintiphotograph.Yttrium Radioisotopes: Unstable isotopes of yttrium that decay or disintegrate emitting radiation. Y atoms with atomic weights 82-88 and 90-96 are radioactive yttrium isotopes.Calcium Carbonate: Carbonic acid calcium salt (CaCO3). An odorless, tasteless powder or crystal that occurs in nature. It is used therapeutically as a phosphate buffer in hemodialysis patients and as a calcium supplement.Tin Radioisotopes: Unstable isotopes of tin that decay or disintegrate emitting radiation. Sn atoms with atomic weights 108-111, 113, 120-121, 123 and 125-128 are tin radioisotopes.Carbon Radioisotopes: Unstable isotopes of carbon that decay or disintegrate emitting radiation. C atoms with atomic weights 10, 11, and 14-16 are radioactive carbon isotopes.Iron Radioisotopes: Unstable isotopes of iron that decay or disintegrate emitting radiation. Fe atoms with atomic weights 52, 53, 55, and 59-61 are radioactive iron isotopes.Phosphorus Radioisotopes: Unstable isotopes of phosphorus that decay or disintegrate emitting radiation. P atoms with atomic weights 28-34 except 31 are radioactive phosphorus isotopes.Copper Radioisotopes: Unstable isotopes of copper that decay or disintegrate emitting radiation. Cu atoms with atomic weights 58-62, 64, and 66-68 are radioactive copper isotopes.Beta Particles: High energy POSITRONS or ELECTRONS ejected from a disintegrating atomic nucleus.Calcium Phosphates: Calcium salts of phosphoric acid. These compounds are frequently used as calcium supplements.Technetium: The first artificially produced element and a radioactive fission product of URANIUM. Technetium has the atomic symbol Tc, atomic number 43, and atomic weight 98.91. All technetium isotopes are radioactive. Technetium 99m (m=metastable) which is the decay product of Molybdenum 99, has a half-life of about 6 hours and is used diagnostically as a radioactive imaging agent. Technetium 99 which is a decay product of technetium 99m, has a half-life of 210,000 years.Mercury Radioisotopes: Unstable isotopes of mercury that decay or disintegrate emitting radiation. Hg atoms with atomic weights 185-195, 197, 203, 205, and 206 are radioactive mercury isotopes.Technetium Tc 99m Sulfur Colloid: A gamma-emitting radionuclide imaging agent used for the diagnosis of diseases in many tissues, particularly in the gastrointestinal system, liver, and spleen.Calcium Chloride: A salt used to replenish calcium levels, as an acid-producing diuretic, and as an antidote for magnesium poisoning.Cesium Isotopes: Stable cesium atoms that have the same atomic number as the element cesium, but differ in atomic weight. Cs-133 is a naturally occurring isotope.Cobalt Isotopes: Stable cobalt atoms that have the same atomic number as the element cobalt, but differ in atomic weight. Co-59 is a stable cobalt isotope.Cerium Radioisotopes: Unstable isotopes of cerium that decay or disintegrate emitting radiation. Ce atoms with atomic weights 132-135, 137, 139, and 141-148 are radioactive cerium isotopes.Hafnium: Hafnium. A metal element of atomic number 72 and atomic weight 178.49, symbol Hf. (From Dorland, 28th ed)Gold Radioisotopes: Unstable isotopes of gold that decay or disintegrate emitting radiation. Au 185-196, 198-201, and 203 are radioactive gold isotopes.Isotope Labeling: Techniques for labeling a substance with a stable or radioactive isotope. It is not used for articles involving labeled substances unless the methods of labeling are substantively discussed. Tracers that may be labeled include chemical substances, cells, or microorganisms.Lead Radioisotopes: Unstable isotopes of lead that decay or disintegrate emitting radiation. Pb atoms with atomic weights 194-203, 205, and 209-214 are radioactive lead isotopes.Diagnostic Techniques, Radioisotope: Any diagnostic evaluation using radioactive (unstable) isotopes. This diagnosis includes many nuclear medicine procedures as well as radioimmunoassay tests.Sulfur Radioisotopes: Unstable isotopes of sulfur that decay or disintegrate spontaneously emitting radiation. S 29-31, 35, 37, and 38 are radioactive sulfur isotopes.Zinc Isotopes: Stable zinc atoms that have the same atomic number as the element zinc, but differ in atomic weight. Zn-66-68, and 70 are stable zinc isotopes.Calcium Channels, L-Type: Long-lasting voltage-gated CALCIUM CHANNELS found in both excitable and nonexcitable tissue. They are responsible for normal myocardial and vascular smooth muscle contractility. Five subunits (alpha-1, alpha-2, beta, gamma, and delta) make up the L-type channel. The alpha-1 subunit is the binding site for calcium-based antagonists. Dihydropyridine-based calcium antagonists are used as markers for these binding sites.Cadmium Radioisotopes: Unstable isotopes of cadmium that decay or disintegrate emitting radiation. Cd atoms with atomic weights 103-105, 107, 109, 115, and 117-119 are radioactive cadmium isotopes.Astatine: Astatine. A radioactive halogen with the atomic symbol At, atomic number 85, and atomic weight 210. Its isotopes range in mass number from 200 to 219 and all have an extremely short half-life. Astatine may be of use in the treatment of hyperthyroidism.Calcium Oxalate: The calcium salt of oxalic acid, occurring in the urine as crystals and in certain calculi.Radioimmunotherapy: Radiotherapy where cytotoxic radionuclides are linked to antibodies in order to deliver toxins directly to tumor targets. Therapy with targeted radiation rather than antibody-targeted toxins (IMMUNOTOXINS) has the advantage that adjacent tumor cells, which lack the appropriate antigenic determinants, can be destroyed by radiation cross-fire. Radioimmunotherapy is sometimes called targeted radiotherapy, but this latter term can also refer to radionuclides linked to non-immune molecules (see RADIOTHERAPY).Lutetium: Lutetium. An element of the rare earth family of metals. It has the atomic symbol Lu, atomic number 71, and atomic weight 175.Rhenium: Rhenium. A metal, atomic number 75, atomic weight 186.2, symbol Re. (Dorland, 28th ed)Calcium Gluconate: The calcium salt of gluconic acid. The compound has a variety of uses, including its use as a calcium replenisher in hypocalcemic states.Samarium: Samarium. An element of the rare earth family of metals. It has the atomic symbol Sm, atomic number 62, and atomic weight 150.36. The oxide is used in the control rods of some nuclear reactors.Radiopharmaceuticals: Compounds that are used in medicine as sources of radiation for radiotherapy and for diagnostic purposes. They have numerous uses in research and industry. (Martindale, The Extra Pharmacopoeia, 30th ed, p1161)Soil Pollutants, Radioactive: Pollutants, present in soil, which exhibit radioactivity.Scintillation Counting: Detection and counting of scintillations produced in a fluorescent material by ionizing radiation.Bromine Radioisotopes: Unstable isotopes of bromine that decay or disintegrate emitting radiation. Br atoms with atomic weights 74-78, 80, and 82-90 are radioactive bromine isotopes.Subdural Effusion: Leakage and accumulation of CEREBROSPINAL FLUID in the subdural space which may be associated with an infectious process; CRANIOCEREBRAL TRAUMA; BRAIN NEOPLASMS; INTRACRANIAL HYPOTENSION; and other conditions.Radioactive Waste: Liquid, solid, or gaseous waste resulting from mining of radioactive ore, production of reactor fuel materials, reactor operation, processing of irradiated reactor fuels, and related operations, and from use of radioactive materials in research, industry, and medicine. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Serum Albumin, Radio-Iodinated: Normal human serum albumin mildly iodinated with radioactive iodine (131-I) which has a half-life of 8 days, and emits beta and gamma rays. It is used as a diagnostic aid in blood volume determination. (from Merck Index, 11th ed)Ruthenium Radioisotopes: Unstable isotopes of ruthenium that decay or disintegrate emitting radiation. Ru atoms with atomic weights 93-95, 97, 103, and 105-108 are radioactive ruthenium isotopes.Intestinal Absorption: Uptake of substances through the lining of the INTESTINES.Radiometric Dating: Techniques used to determine the age of materials, based on the content and half-lives of the RADIOACTIVE ISOTOPES they contain.Selenium Radioisotopes: Unstable isotopes of selenium that decay or disintegrate emitting radiation. Se atoms with atomic weights 70-73, 75, 79, 81, and 83-85 are radioactive selenium isotopes.Tissue Distribution: Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.Alpha Particles: Positively charged particles composed of two protons and two NEUTRONS, i.e. equivalent to HELIUM nuclei, which are emitted during disintegration of heavy ISOTOPES. Alpha rays have very strong ionizing power, but weak penetrability.Calcium Compounds: Inorganic compounds that contain calcium as an integral part of the molecule.Kinetics: The rate dynamics in chemical or physical systems.Heterocyclic Compounds, 1-Ring: A class of organic compounds containing a ring structure made up of more than one kind of atom, usually carbon plus another atom. The ring structure can be aromatic or nonaromatic.Sodium Pertechnetate Tc 99m: A gamma-emitting radionuclide imaging agent used for the diagnosis of diseases in many tissues, particularly in the gastrointestinal system, cardiovascular and cerebral circulation, brain, thyroid, and joints.Tungsten: Tungsten. A metallic element with the atomic symbol W, atomic number 74, and atomic weight 183.85. It is used in many manufacturing applications, including increasing the hardness, toughness, and tensile strength of steel; manufacture of filaments for incandescent light bulbs; and in contact points for automotive and electrical apparatus.Isotopes: Atomic species differing in mass number but having the same atomic number. (Grant & Hackh's Chemical Dictionary, 5th ed)Calcium Channels, N-Type: CALCIUM CHANNELS that are concentrated in neural tissue. Omega toxins inhibit the actions of these channels by altering their voltage dependence.Pentetic Acid: An iron chelating agent with properties like EDETIC ACID. DTPA has also been used as a chelator for other metals, such as plutonium.Methods: A series of steps taken in order to conduct research.Radioisotope Teletherapy: A type of high-energy radiotherapy using a beam of gamma-radiation produced by a radioisotope source encapsulated within a teletherapy unit.Egtazic Acid: A chelating agent relatively more specific for calcium and less toxic than EDETIC ACID.Spectrometry, Gamma: Determination of the energy distribution of gamma rays emitted by nuclei. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Time Factors: Elements of limited time intervals, contributing to particular results or situations.Nuclear Medicine: A specialty field of radiology concerned with diagnostic, therapeutic, and investigative use of radioactive compounds in a pharmaceutical form.Technetium Tc 99m Pentetate: A technetium imaging agent used in renal scintigraphy, computed tomography, lung ventilation imaging, gastrointestinal scintigraphy, and many other procedures which employ radionuclide imaging agents.Calcium Channel Agonists: Agents that increase calcium influx into calcium channels of excitable tissues. This causes vasoconstriction in VASCULAR SMOOTH MUSCLE and/or CARDIAC MUSCLE cells as well as stimulation of insulin release from pancreatic islets. Therefore, tissue-selective calcium agonists have the potential to combat cardiac failure and endocrinological disorders. They have been used primarily in experimental studies in cell and tissue culture.Radiometry: The measurement of radiation by photography, as in x-ray film and film badge, by Geiger-Mueller tube, and by SCINTILLATION COUNTING.Absorption: The physical or physiological processes by which substances, tissue, cells, etc. take up or take in other substances or energy.Rosaniline Dyes: Compounds that contain the triphenylmethane aniline structure found in rosaniline. Many of them have a characteristic magenta color and are used as COLORING AGENTS.TritiumNostoc commune: A form species of spore-producing CYANOBACTERIA, in the family Nostocaceae, order Nostocales. It is an important source of fixed NITROGEN in nutrient-depleted soils. When wet, it appears as a jelly-like mass.Whole-Body Counting: Measurement of radioactivity in the entire human body.Potassium Radioisotopes: Unstable isotopes of potassium that decay or disintegrate emitting radiation. K atoms with atomic weights 37, 38, 40, and 42-45 are radioactive potassium isotopes.Calcimycin: An ionophorous, polyether antibiotic from Streptomyces chartreusensis. It binds and transports CALCIUM and other divalent cations across membranes and uncouples oxidative phosphorylation while inhibiting ATPase of rat liver mitochondria. The substance is used mostly as a biochemical tool to study the role of divalent cations in various biological systems.Fluorescent Dyes: Agents that emit light after excitation by light. The wave length of the emitted light is usually longer than that of the incident light. Fluorochromes are substances that cause fluorescence in other substances, i.e., dyes used to mark or label other compounds with fluorescent tags.Iodohippuric Acid: An iodine-containing compound used in pyelography as a radiopaque medium. If labeled with radioiodine, it can be used for studies of renal function.Bone and Bones: A specialized CONNECTIVE TISSUE that is the main constituent of the SKELETON. The principle cellular component of bone is comprised of OSTEOBLASTS; OSTEOCYTES; and OSTEOCLASTS, while FIBRILLAR COLLAGENS and hydroxyapatite crystals form the BONE MATRIX.Carbon Isotopes: Stable carbon atoms that have the same atomic number as the element carbon, but differ in atomic weight. C-13 is a stable carbon isotope.Calcium Hydroxide: A white powder prepared from lime that has many medical and industrial uses. It is in many dental formulations, especially for root canal filling.Rabbits: The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.Phosphorus: A non-metal element that has the atomic symbol P, atomic number 15, and atomic weight 31. It is an essential element that takes part in a broad variety of biochemical reactions.Nifedipine: A potent vasodilator agent with calcium antagonistic action. It is a useful anti-anginal agent that also lowers blood pressure.Calcium Sulfate: A calcium salt that is used for a variety of purposes including: building materials, as a desiccant, in dentistry as an impression material, cast, or die, and in medicine for immobilizing casts and as a tablet excipient. It exists in various forms and states of hydration. Plaster of Paris is a mixture of powdered and heat-treated gypsum.Radiation Dosage: The amount of radiation energy that is deposited in a unit mass of material, such as tissues of plants or animal. In RADIOTHERAPY, radiation dosage is expressed in gray units (Gy). In RADIOLOGIC HEALTH, the dosage is expressed by the product of absorbed dose (Gy) and quality factor (a function of linear energy transfer), and is called radiation dose equivalent in sievert units (Sv).Parathyroid Hormone: A polypeptide hormone (84 amino acid residues) secreted by the PARATHYROID GLANDS which performs the essential role of maintaining intracellular CALCIUM levels in the body. Parathyroid hormone increases intracellular calcium by promoting the release of CALCIUM from BONE, increases the intestinal absorption of calcium, increases the renal tubular reabsorption of calcium, and increases the renal excretion of phosphates.Sodium: A member of the alkali group of metals. It has the atomic symbol Na, atomic number 11, and atomic weight 23.

Modulation of calcium mobilization in aortic rings of pregnant rats: Contribution of extracellular calcium and of voltage-operated calcium channels. (1/407)

Pregnancy is associated with decreased vascular responsiveness to vasopressor stimuli. We have tested the involvement of Ca2+ mobilization in myotropic responses of aortic rings obtained from pregnant and virgin rats. Contractions of the rings to phenylephrine, in the absence of calcium in the bathing medium, were lower in tissues from virgin than from pregnant rats. Concentration-response curves to CaCl2 that were measured after stimulation by phenylephrine in the absence of Ca2+ were shifted to higher levels of contraction. This was not observed when KCl was used to prestimulate the aorta. D-600, a phenylalkylamine calcium channel blocker, similarly inhibited these responses to CaCl2 in tissues from both pregnant and virgin animals. D-600 exerted a concentration-dependent inhibition of responses to phenylephrine and KCl. However, the calcium antagonist was less effective in aortic rings of pregnant than of virgin rats. Basal 45Ca2+ uptake was lower in aortic rings from pregnant than from virgin rats, and Bay K 8644 was unable to reverse this difference. The time course of basal and stimulated (KCl) 45Ca2+ influx was lower in aorta of pregnant rats at all times studied. Moreover, when the intracellular calcium pools were emptied with phenylephrine, the refilling of these pools was delayed in aortic rings of pregnant rats. These results indicate an altered extracellular calcium mobilization of aortic rings from pregnant rats. These changes may be due to a functional alteration of the voltage-operated calcium channels during pregnancy.  (+info)

A non-pungent triprenyl phenol of fungal origin, scutigeral, stimulates rat dorsal root ganglion neurons via interaction at vanilloid receptors. (2/407)

1. A [3H]-resiniferatoxin (RTX) binding assay utilizing rat spinal cord membranes was employed to identify novel vanilloids in a collection of natural products of fungal origin. Of the five active compounds found (scutigeral, acetyl-scutigeral, ovinal, neogrifolin, and methyl-neogrifolin), scutigeral (Ki=19 microM), isolated from the edible mushroom Albatrellus ovinus, was selected for further characterization. 2. Scutigeral induced a dose-dependent 45Ca uptake by rat dorsal root ganglion neurons with an EC50 of 1.6 microM, which was fully inhibited by the competitive vanilloid receptor antagonist capsazepine (IC50=5.2 microM). 3. [3H]-RTX binding isotherms were shifted by scutigeral (10-80 microM) in a competitive manner. The Schild plot of the data had a slope of 0.8 and gave an apparent Kd estimate for scutigeral of 32 microM. 4. Although in the above assays scutigeral mimicked capsaicin, it was not pungent on the human tongue up to a dose of 100 nmol per tongue, nor did it provoke protective wiping movements in the rat (up to 100 microM) upon intraocular instillation. 5. In accord with being non-pungent, scutigeral (5 microM) did not elicit a measurable inward current in isolated rat dorsal root ganglion neurons under voltage-clamp conditions. It did, however, reduce the proportion of neurons (from 61 to 15%) that responded to a subsequent capsaicin (1 microM) challenge. In these neurons, scutigeral both delayed (from 27 to 72 s) and diminished (from 5.0 to 1.9 nA) the maximal current evoked by capsaicin. 6. In conclusion, scutigeral and its congeners form a new chemical class of vanilloids, the triprenyl phenols. Scutigeral promises to be a novel chemical lead for the development of orally active, non-pungent vanilloids.  (+info)

Ni2+ transport by the human Na+/Ca2+ exchanger expressed in Sf9 cells. (3/407)

The mechanism of Ni2+ block of the Na+/Ca2+ exchanger was examined in Sf 9 cells expressing the human heart Na+/Ca2+ exchanger (NCX1-NACA1). As predicted from the reported actions of Ni2+, its application reduced extracellular Na+-dependent changes in intracellular Ca2+ concentration (measured by fluo 3 fluorescence changes). However, contrary to expectation, the reduced fluorescence was accompanied by measured 63Ni2+ entry. The 63Ni2+ entry was observed in Sf 9 cells expressing the Na+/Ca2+ exchanger but not in control cells. The established sequential transport mechanism of the Na+/Ca2+ exchanger could be compatible with these results if one of the two ion translocation steps is blocked by Ni2+ and the other permits Ni2+ translocation. We conclude that, because Ni2+ entry was inhibited by extracellular Ca2+ and enhanced by extracellular Na+, the Ca2+ translocation step moved Ni2+, whereas the Na+ translocation step was inhibited by Ni2+. A model is presented to discuss these findings.  (+info)

Chronic fluoride ingestion decreases 45Ca uptake by rat kidney membranes. (4/407)

High exposures to fluoride (F-) may occur in environments rich in F- from natural or industrial sources and from misuse of F--containing dental care products, particularly by children. Both acute and chronic exposures to elevated levels of F- have negative effects on several calcium-dependent processes, including kidney glomerular and tubular function. We examined the effect of chronic F- ingestion on ATP-dependent 45Ca uptake by rat kidney membrane vesicles to characterize the mechanism by which high F- alters Ca++ transport in the kidney. Twenty weanling female Sprague-Dawley rats were raised on low-F- (0.9 mg/L), semi-purified diet with a Ca++ concentration of 400 mg/100g diet. Rats were divided into four groups and were fed ad libitum deionized water containing F- at 0, 10, 50, or 150 mg/L added as NaF for 6 wk. This consumption produced plasma F- levels of <0.4, 2, 7, or 35 micromol/L, respectively. ATP-dependent 45Ca uptake was significantly lower in the 150 mg F-/L exposure group than in the 0 mg F-/L controls (P < 0.05). Studies with thapsigargin, a specific inhibitor of the endoplasmic reticulum Ca++-pump, showed that the lower uptake was associated with significantly lower activities of both the plasma membrane Ca++-pump (P < 0.05, 150 mg F-/L group versus control) and endoplasmic reticulum Ca++-pump (P < 0.05 for both the 50 and 150 mg F-/L groups versus control). Slot blot analysis of kidney homogenates with specific Ca++-pump antibodies showed less (P < 0.05) endoplasmic reticulum Ca++-pump protein and plasma membrane Ca++-pump protein in all treatment groups than controls. Both Ca++-pumps are transport molecules of great importance in the regulation of Ca++ homeostasis. Our study suggests that chronic, high F- ingestion producing high plasma F- levels may occur in humans and may affect Ca++ homeostasis by increasing the turnover or breakdown or decreasing the expression of plasma membrane and endoplasmic reticulum Ca++-pump proteins.  (+info)

Stimulation of neutrophils by prenylcysteine analogs: Ca(2+) release and influx. (5/407)

Farnesylthiosalicylic acid (FTS), a synthetic analog of the terminal prenylcysteine present in signaling proteins induces generation of superoxide ions, phospholipase C-driven hydrolysis of inositol lipids and calcium elevation in human neutrophils and DMSO-differentiated HL60 cells. These effects were ascribed to an interaction of the analog with elements responsible for recognition of specific prenylated proteins. The present study demonstrated that in addition to the release of intracellular calcium stores, FTS enhanced entry of Ca(2+) and Mn(2+) from the medium. The biphasic dependence of the influx on the concentration of FTS, as well as its insensitivity to inhibition by PMA and La(3+) suggest that the influx pathway activated by FTS is distinct from the previously described store-operated calcium channels of neutrophils. Consistent with the participation of a cellular membrane component in the interaction, FTS enhanced (45)Ca uptake in neutrophils and neutrophil cell membranes, but not in multilamellar vesicles. To establish specificity of the farnesyl moiety of FTS (C(15)), effects of three other analogs, geranylthiosalicylate, GTS (C(10)), geranylgeranylthiosalicylate, GGTS (C(20)), as well as the carboxymethyl ester FTS-Me on calcium homeostasis and superoxide production were investigated. GGTS dose-dependently elevated [Ca(2+)](i), induced quenching of the 360 nm Fura-2-calcium fluorescence by Mn(2+) and stimulated superoxide release, while GTS and FTS-Me were inactive. These results defined specific structural requirements for the functional interaction of prenylcysteine analogs with myeloid cells.  (+info)

Intracellular Ca(2+)-Mg(2+)-ATPase regulates calcium influx and acrosomal exocytosis in bull and ram spermatozoa. (6/407)

Calcium influx is required for the mammalian sperm acrosome reaction (AR), an exocytotic event occurring in the sperm head prior to fertilization. We show here that thapsigargin, a highly specific inhibitor of the microsomal Ca(2+)-Mg(2+)-ATPase (Ca(2+) pump), can initiate acrosomal exocytosis in capacitated bovine and ram spermatozoa. Initiation of acrosomal exocytosis by thapsigargin requires an influx of Ca(2+), since incubation of cells in the absence of added Ca(2+) or in the presence of the calcium channel blocker, La(3+), completely inhibited thapsigargin-induced acrosomal exocytosis. ATP-Dependent calcium accumulation into nonmitochondrial stores was detected in permeabilized sperm in the presence of ATP and mitochondrial uncoupler. This activity was inhibited by thapsigargin. Thapsigargin elevated the intracellular Ca(2+) concentration ([Ca(2+)](i)), and this increase was inhibited when extracellular Ca(2+) was chelated by EGTA, indicating that this rise in Ca(2+) is derived from the external medium. This rise of [Ca(2+)](i) took place first in the head and later in the midpiece of the spermatozoon. However, immunostaining using a polyclonal antibody directed against the purified inositol 1,4,5-tris-phosphate receptor (IP(3)-R) identified specific staining in the acrosome region, in the postacrosome, and along the tail, but not in the midpiece region. No staining in the acrosome region was observed in sperm without acrosome, indicating that the acrosome cap was stained in intact sperm. The presence of IP(3)-R in the anterior acrosomal region as well as the induction, by thapsigargin, of intracellular Ca(2+) elevation in the acrosomal region and acrosomal exocytosis, implicates the acrosome as a potential cellular Ca(2+) store. We suggest here that the cytosolic Ca(2+) is actively transported into the acrosome by an ATP-dependent, thapsigargin-sensitive Ca(2+) pump and that the accumulated Ca(2+) is released from the acrosome via an IP(3)-gated calcium channel. The ability of thapsigargin to increase [Ca(2+)](i) could be due to depletion of Ca(2+) in the acrosome, resulting in the opening of a capacitative calcium entry channel in the plasma membrane. The effect of thapsigargin on elevated [Ca(2+)](i) in capacitated cells was 2-fold higher than that in noncapacitated sperm, suggesting that the intracellular Ca pump is active during capacitation and that this pump may have a role in regulating [Ca(2+)](i) during capacitation and the AR.  (+info)

Demonstration of the rapid action of pure crystalline 1 alpha-hydroxy vitamin D3 and 1 alpha,25-dihydroxy vitamin D3 on intestinal calcium uptake. (7/407)

The biological effects of crystalline 1alpha-hydroxyvitamin D3 and crystalline 1alpha,25-dihydroxyvitamin D3 have been compared on the intestinal uptake of calcium-45 by everted duodenal gut sacs from rachitic rats. Peak calcium-45 uptake was observed 1 hr after intravenous administration and both crystalline vitamin D2 analogs were of comparable potency. The rapid onset of calcium-45 uptake and the rapid attainment of maximal calcium-45 transport suggests a direct effect of these crystalline analogs on the mucosal membranes of the intestinal cell.  (+info)

Xestoquinone, isolated from sea sponge, causes Ca(2+) release through sulfhydryl modification from skeletal muscle sarcoplasmic reticulum. (8/407)

Xestoquinone (XQN) (3 x 10(-7) to 3 x 10(-3) M), isolated from the sea sponge Xestospongia sapra, induced a concentration-dependent Ca(2+) release from the heavy fraction of fragmented sarcoplasmic reticulum (HSR) of rabbit skeletal muscle with an EC(50) value of approximately 30 microM. On the basis of the EC(50), XQN is 10 times more potent than caffeine. Dithiothreitol completely blocked XQN-induced Ca(2+) release from HSR without affecting that induced by caffeine. Caffeine-induced Ca(2+) release was reduced markedly by Mg(2+), procaine, and ruthenium red, agents that are known to block release of Ca(2+) from sarcoplasmic reticulum, whereas that induced by XQN was not inhibited. The bell-shaped profile of Ca(2+) dependence for XQN was significantly shifted upward in a wider range of pCa (between 7 and 3), whereas that for caffeine was shifted to the left in a narrower range of pCa (between 8 and 7). The maximum response to caffeine in (45)Ca(2+) release was not affected by 9-methyl-7-bromoeudistomin D, whereas the response was further increased by XQN. XQN caused a concentration-dependent decrease in [(3)H]ryanodine binding to HSR. This effect of XQN also was abolished in the presence of dithiothreitol. Scatchard analysis revealed that the mode of inhibition by XQN was noncompetitive in [(3)H]ryanodine binding to HSR. These results indicate that sulfhydryl groups are involved in both the XQN effect on ryanodine binding and on Ca(2+) release.  (+info)

The error you encountered has nothing to do with the presence of an ion accumulation mechanism. Impdedance.compute can be used in models that have ion accumulation mechanisms. The point of the "Warning" is to bring a potential source of error to the readers attention. Whether this particular error is significant or not in any particular model depends on the details of the model and is an empirical question--one that could be resolved by a computational experiment, similar to what you proposed: calculating impedance by injecting current and recording the resulting voltage. Keep in mind the fact that every model that does not include ion accumulation for each and every ionic species that crosses the cell membrane is itself full of potential sources of error. And for those few ionic species whose concentrations are state variables, in most cases it seems likely that the amplitude of ionic concentration changes is either small and characterized by a very slow time course compared to the amplitude ...
During early reperfusion (in the first minutes), occurs a rapid correction of acidosis (low intracellular pH) through the Na+/H+ exchanger, and through the entry of the ion HCO3 by the Na/HCO3 symporter (Figure 2). Additionally, the lactate, previously accumulated, is washed out with the restored blood flow diminishing the acidosis. However, all these events cause accumulation of Na+. This additional augment in intracellular sodium induces a secondary activation of the Na+/Ca2+ exchanger in the reverse mode to move out Na+ ions; however, this aggravates cytosolic Ca2+ accumulation. On the other hand, the abrupt re exposure of the ischemia inhibited mitochondrial respiratory chain to oxygen generates a membrane potential to drive ATP synthesis, which leads to a rapid overload of Ca2+ in the matrix and massive production of reactive oxygen species (ROS), which by themselves are capable of damaging cellular membranes and to induce oxidative stress. These two factors (cytosolic Ca accumulation and ...
In previous efforts to characterize sarcoplasmic reticulum function in human muscles, it has not been possible to distinguish the relative contributions of fast-twitch and slow-twitch fibers. In this study, we have used light scattering and 45Ca to monitor Ca accumulation by the sarcoplasmic reticulum of isolated, chemically skinned human muscle fibers in the presence and absence of oxalate. Oxalate (5 mM) increased the capacity for Ca accumulation by a factor of 35 and made it possible to assess both rate of Ca uptake and relative sarcoplasmic reticulum volume in individual fibers. At a fixed ionized Ca concentration, the rate and maximal capacity (an index of sarcoplasmic reticulum volume) both varied over a wide range, but fibers fell into two distinct groups (fast and slow). Between the two groups, there was a 2- to 2.5-fold difference in oxalate-supported Ca uptake rates, but no difference in average sarcoplasmic reticulum volumes. Intrinsic differences in sarcoplasmic reticulum function ...
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Ca2+ release in saponin-permeabilized calreticulin-deficient cells. Wild-type (K41) and calreticulin-deficient (K42) cells were loaded with a fluorescent Ca2+ i
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Areas of active investigation include: use of laser-scanning confocal microscopy to measure "calcium sparks", which are brief localized increases in fluorescence from a Ca-indicator such as fluo-3 that are thought to be reflective of the transient opening of one or a few RyRs (=ryanodine receptors), the Ca release channels of the sarcoplasmic reticulum (SR); the possibility that the mechanism of activation of RyRs involves both voltage-gating and Ca-gating; the nature of the mechanism whereby SR Ca release is inactivated by a rise in myoplasmic free [Ca]; the possibility that either activation or inactivation of SR Ca release may vary with the RyR isoform composition (RyR1, RyR3, etc.); estimation of local Ca movements within the sarcomere by means of computer modeling, including estimation of the kinetics of binding of Ca to the intracellular Ca buffers troponin, parvalbumin, ATP, and the SR Ca pump ...
Ošiņa K.; Rostoka E.; Sokolovska J.; Paramonova N.; Bisenieks E.; Duburs G.; Sjakste N.; Sjakste T. 1,4-Dihydropyridine derivatives without Ca2+-antagonist activity up-regulate Psma6 mRNA expression in kidneys of intact and diabetic rats. Cell Biochem. Funct. 2016, 34(1), 3-6 ...
Calcium content and RDA percentage, per serving and per 100g, in 7 types of figs. The amount of Calcium is 162 mg to 26 mg per 100g, in figs.
Another use is as a carrier of strontium-90 radioisotope in radioisotope thermoelectric generators. Greenwood, Norman N.; ... Its optical properties are intermediate to calcium fluoride and barium fluoride. Strontium fluoride is used as an optical ...
Several radioisotopes of strontium, for example, are recognized as analogs of calcium and incorporated within Micrococcus ... Radioisotopes can be transformed directly through changes in valence state by acting as acceptors or by acting as cofactors to ... The radioisotope interact with binding sites of metabolically active cells and is used as terminal electron acceptor in the ... Moreover, in groundwater abound radius radioisotopes such as radium-226 and radium-228 (228Ra). They are also habitual in ...
In the presence of calcium ions, strontium commonly forms coprecipitates with calcium minerals such as calcite and anhydrite at ... "Radioisotopes That May Impact Food Resources" (PDF). Epidemiology, Health and Social Services, State of Alaska. Retrieved 14 ... The similarity to calcium and the chance that the strontium-90 might become enriched in bones made research on the metabolism ... In biological systems, calcium is substituted in a small extent by strontium. In the human body, most of the absorbed strontium ...
Thirty radioisotopes have been characterized, with the most stable being alpha-decaying 152Gd (naturally occurring) with a half ... It can also detect the loss of calcium in the hip and back bones, allowing the ability to diagnose osteoporosis. Gadolinium-148 ... "Radioisotope Power Systems: An Imperative for Maintaining U.S. Leadership in Space Exploration". 2009. doi:10.17226/12653. " ... It ensures that the machines work correctly to produce images of radioisotope distribution inside the patient. This isotope is ...
This paper also reports details of the effect of potassium, ammonium and calcium ions on the uptake of the radioisotopes. ... Some of these radioisotopes are tritium, carbon-14 and phosphorus-32. Here is a list of radioisotopes formed by the action of ... This radioisotope can be released from the nuclear fuel cycle; this is the radioisotope responsible for the majority of the ... In addition some natural radioisotopes are present. A recent paper reports the levels of long-lived radioisotopes in the ...
This paper also reports details of the effect of potassium, ammonium and calcium ions on the uptake of the radioisotopes. In ... Just because a radioisotope is released it does not mean it will enter a human and then cause harm. For instance, the migration ... Most nuclear fuel is uranium dioxide, which is a cubic solid with a structure similar to that of calcium fluoride. In used fuel ... If the radioisotope is tightly bound to the minerals in the soil, then less radioactivity can be absorbed by crops and grass ...
Beryllium-7, beryllium-10, and calcium-41 are trace radioisotopes; calcium-48 and barium-130 have very long half-lives and thus ... Calcium-48 is the lightest nuclide to undergo double beta decay. Calcium and barium are weakly radioactive: calcium contains ... Calcium as a material has been known since at least the first century, as the ancient Romans were known to have used calcium ... Of the six alkaline earth metals, beryllium, calcium, barium, and radium have at least one naturally occurring radioisotope; ...
There is a section for each radioisotope with a table of radiopharmaceuticals using that radioisotope. The sections are ordered ... Calcium-47Edit. 47Ca is a beta and gamma emitter. Name Investigation Route of administration In-vitro / in-vivo Imaging / non- ... Some radioisotopes* are used in ionic or inert form without attachment to a pharmaceutical, these are also included. ... making it more useful as a therapeutic isotope for brachytherapy implant of radioisotope capsules for local treatment of ...
It causes health problems, as it substitutes for calcium in bone, preventing expulsion from the body. Because it is a long- ... 89Sr is an artificial radioisotope used in treatment of bone cancer. In circumstances where cancer patients have widespread and ... Because strontium has an electron configuration similar to that of calcium, it readily substitutes for Ca in minerals. ...
The strontium radioisotopes are very important as strontium is a calcium mimic which is incorporated in bone growth and ... It is the most significant radioisotope left in the area around Chernobyl. IAEA map Caesium-134 is found in spent nuclear fuel ...
An example is 90Sr, which behaves chemically like calcium and can replace the calcium in bones. Other bone seekers include ... A bone seeker is an element, often a radioisotope, that tends to accumulate in the bones of humans and other animals when it is ...
The Sulfur may be present as sulfates of sodium, magnesium, calcium, or iron. A sulfide of iron is also possible. The Spirit ... The Viking 2 lander was powered by radioisotope generators and operated on the surface until April 11, 1980, when its batteries ... The tested soil contained abundant silicon and iron, along with significant amounts of magnesium, aluminum, sulfur, calcium, ... The Opportunity rover (landed in 2004 with advanced instruments) found magnesium sulfate and calcium sulfate at Meridiani ...
Apart from the practically stable 48Ca, the longest lived radioisotope of calcium is 41Ca. It decays by electron capture to ... For example, calcium and phosphorus are supplemented in foods through the addition of calcium lactate, calcium diphosphate, and ... Calcium Scandium Titanium Vanadium Chromium Manganese Iron Cobalt Nickel Copper Zinc Gallium Germanium Arsenic Selenium Bromine ... All four dihalides of calcium are known.[14] Calcium carbonate (CaCO3) and calcium sulfate (CaSO4) are particularly abundant ...
Here is a list of radioisotopes formed by the action of cosmic rays; the list also contains the production mode of the isotope ... notably calcium-41 in the table below. Greenwood, Norman N.; Earnshaw, Alan (1997). Chemistry of the Elements (2nd ed.). ... Some of these radioisotopes are tritium, carbon-14 and phosphorus-32. Certain light (low atomic number) primordial nuclides ( ...
Beryllium-7, beryllium-10, and calcium-41 are trace radioisotopes; calcium-48 and barium-130 have very long half-lives and thus ... Calcium-48 is the lightest nuclide to undergo double beta decay.[21] Calcium and barium are weakly radioactive: calcium ... Calcium Scandium Titanium Vanadium Chromium Manganese Iron Cobalt Nickel Copper Zinc Gallium Germanium Arsenic Selenium Bromine ... Of the six alkaline earth metals, beryllium, calcium, barium, and radium have at least one naturally occurring radioisotope; ...
Blackwell (1962) Calcium and phosphorus metabolism in man and animals with special reference to pregnancy and lactation. ... Chicago U.P. (1st ed 1955; 3rd ed 1968 ISBN 0-226-56073-2) Radioisotopes and bone : a symposium organized by the Council for ...
Calcium carbonate is decomposed, producing carbon dioxide and calcium oxide. Water and carbon dioxide penetrate the corium mass ... An eventually present layer of more dense molten metal, containing fewer radioisotopes (Ru, Tc, Pd, etc., initially composed of ... The calcium oxide, silica, and silicates melt and are mixed into the corium. The oxide phase, in which the nonvolatile fission ... mainly a calcium aluminosilicate with small amount of magnesium oxide, sodium oxide, and zirconium dioxide metal, present as ...
Strontium belongs to the same periodic family as calcium (alkaline earth metals), and is metabolised in a similar fashion. 89Sr ... It is an artificial radioisotope which is used in treatment of bone cancer. In circumstances where cancer patients have ... where calcium turnover is greatest. Isotopes of strontium Alpharadin, Radium-223 with similar clinical use. Delacroix, D.; P. ...
... calcium radioisotopes MeSH D01.496.123.328 --- carbon radioisotopes MeSH D01.496.156.300 --- cerium radioisotopes MeSH D01.496. ... calcium radioisotopes MeSH D01.496.749.154 --- carbon radioisotopes MeSH D01.496.749.185 --- cerium radioisotopes MeSH D01.496. ... cobalt radioisotopes MeSH D01.496.360.400 --- gallium radioisotopes MeSH D01.496.381.550 --- gold radioisotopes MeSH D01.496. ... iron radioisotopes MeSH D01.496.532.500 --- mercury radioisotopes MeSH D01.496.586.520 --- nitrogen radioisotopes MeSH D01.496. ...
This event has been radioisotope dated to around 470±6 million years ago. The parent body/bodies for this group are not known, ... Chromite, sodium-rich feldspar and calcium phosphates occur in minor amounts. Petrologic type 6 dominates, with over 60% of the ...
All of the remaining radioisotopes have half-lives that are less than two days, and the majority of these have half-lives that ... It is treated by the body in a similar manner to calcium, and it localizes selectively to bone. Bold for isotopes with half- ... Other than the naturally occurring isotopes, the longest-lived radioisotopes are 151Sm, which has a half-life of 88.8 years, ... and two extremely long-lived radioisotopes, 147Sm (half life: 1.06×1011 y) and 148Sm (7×1015 y), with 152Sm being the most ...
Apart from the practically stable 48Ca, the longest lived radioisotope of calcium is 41Ca. It decays by electron capture to ... Other calcium preparations include calcium carbonate, calcium citrate malate, and calcium gluconate.[5] The intestine absorbs ... For example, calcium and phosphorus are supplemented in foods through the addition of calcium lactate, calcium diphosphate, and ... Calcium Scandium Titanium Vanadium Chromium Manganese Iron Cobalt Nickel Copper Zinc Gallium Germanium Arsenic Selenium Bromine ...
The most stable artificial radioisotope is 45Ca, with a half-life of 163 days. All other calcium isotopes have half-lives of ... Calcium (20Ca) has 24 isotopes, from 34Ca to 57Ca. There are five stable isotopes (40Ca, 42Ca, 43Ca, 44Ca and 46Ca), plus one ... Calcium also has a cosmogenic isotope, radioactive 41Ca, which has a half-life of 102,000 years. Unlike cosmogenic isotopes ... Calcium. ed. A. Jorgenson and C. Cleveland. Encyclopedia of Earth, National Council for Science and the Environment, Washington ...
Calcium Scandium Titanium Vanadium Chromium Manganese Iron Cobalt Nickel Copper Zinc Gallium Germanium Arsenic Selenium Bromine ... About 20 radioisotopes and 7 nuclear isomers between 233Cm and 252Cm are known for curium, and no stable isotopes. The longest ... Thus, bombardment of 248Cm with neon (22Ne), magnesium (26Mg), or calcium (48Ca) yielded certain isotopes of seaborgium (265Sg ... They predominantly emit α-particles, and the heat released in this process can serve as a heat source in radioisotope ...
Silicon-32 Phosphorus-32 Sulfur-35 Sulfur-38 Chlorine-34m Chlorine-36 Chlorine-38 Chlorine-39 Argon-39 Argon-42 Calcium-41 Iron ... A trace radioisotope is a radioisotope that occurs naturally in trace amounts (i.e. extremely small). Generally speaking, trace ... Trace radioisotopes are therefore present only because they are continually produced on Earth by natural processes. Natural ... radioisotopes have half-lives that are short in comparison with the age of the Earth, since primordial nuclides tend to occur ...
The blue fluorescence of Tm-doped calcium sulfate has been used in personal dosimeters for visual monitoring of radiation. Tm- ... Thulium-170 is one of the four most popular radioisotopes for use in industrial radiography. Thulium has been used in high- ... The metal can be isolated through reduction of its oxide with lanthanum metal or by calcium reduction in a closed container. ...
Calcium Scandium Titanium Vanadium Chromium Manganese Iron Cobalt Nickel Copper Zinc Gallium Germanium Arsenic Selenium Bromine ... Radioisotopes of caesium require special precautions: the improper handling of caesium-137 gamma ray sources can lead to ... Similar solutions are formed by the heavy divalent alkaline earth metals calcium, strontium, barium, as well as the divalent ... All of the alkali metals except lithium and caesium have at least one naturally occurring radioisotope: sodium-22 and sodium-24 ...
used in radioisotope thermoelectric generators (RTGs) and radioisotope heater units as an energy source for spacecraft ... Calcium-41 20. 21. 102,000 y. EC. Cosmogenic. exposure dating of carbonate rocks ... "Radioisotopes in Industry". World Nuclear Association.. *. Martin, James (2006). Physics for Radiation Protection: A Handbook. ... most commonly used medical radioisotope, used as a radioactive tracer Iodine-129 53. 76. 15,700,000 y. β−. 194 Cosmogenic. ...
Calcium and Vitamin Supplements Radioisotope Scan Osteoporosis Diet for Kidney stones Death Facts Heart Healthy Heart ... Calcium and Vitamin Supplements. Calcium and vitamin supplements are taken to provide the body with the required nutrients ... CAC uses a CT scan to detect calcium build-up in the arteries of the heart. According to Bowden, the cost of the test is ... Radioisotope Scan Encyclopedia section of medindia gives general info about Nuclear Medicine ...
A simple CT imaging technique called a coronary artery calcium scan may be particularly useful when screening for coronary ... Calcium and Vitamin Supplements Radioisotope Scan Osteoporosis Diet for Kidney stones Heart Healthy Heart Statins Mitral Valve ... Coronary Artery Calcium Score. Coronary calcium builds up at the site of coronary plaque, so a CAC scan can be effective in ... Calcium and Vitamin Supplements. Calcium and vitamin supplements are taken to provide the body with the required nutrients ...
Administration, Oral; Adsorption; Animals; Calcium; Cesium Radioisotopes; Lanthanum; Male; Mice; Mice, Inbred Strains; Phytic ...
Strontium; Metal compounds; Calcium; Bone structure; Radioisotopes; X-ray fluorescence analysis; Humans; Children; In vivo ... Previous technology uses radioisotope sources and bulky equipment to measure bone Sr. This study demonstrates the effectiveness ...
... use of radioisotopes to assess intestinal flux of calcium in humans; and calcium and structure of cell membranes. The ... Basis of Action of Hormones on Calcium Absorption Effects of pH and Counter-ion on Absorption of Metal Ions Vascular Factors in ... The Intestinal Absorption of Calcium Absorption of Iron and Chemically Related Metals in Vitro and in Vivo Intestinal ... The book takes a look at the intestinal absorption of sodium, calcium, and potassium, including sodium and potassium transport ...
used in radioisotope thermoelectric generators (RTGs) and radioisotope heater units as an energy source for spacecraft ... Calcium-41 20. 21. 102,000 y. EC. Cosmogenic. exposure dating of carbonate rocks ... "Radioisotopes in Industry". World Nuclear Association.. *. Martin, James (2006). Physics for Radiation Protection: A Handbook. ... most commonly used medical radioisotope, used as a radioactive tracer Iodine-129 53. 76. 15,700,000 y. β−. 194 Cosmogenic. ...
Coronary calcium predicts the angiographic extent of CAD in symptomatic patients and provides independent and incremental ... Thallium Radioisotopes * Tomography, Emission-Computed, Single-Photon* / methods * Tomography, Emission-Computed, Single-Photon ... Conclusions: Coronary calcium predicts the angiographic extent of CAD in symptomatic patients and provides independent and ... The EBCT-derived total calcium scores were obtained in 291 patients, risk factors as defined by the National Cholesterol ...
... is a type of arthritis caused by the deposition of calcium pyrophosphate crystals. Clinical Image Atlas : View clinical images ... Extraosseous calcific deposits may also take up the radioisotope.. Nuclear imaging procedures are highly sensitive; however, ... Calcium pyrophosphate deposition disease (CPDD) is a type of arthritis caused by the deposition of calcium pyrophosphate ... Primary calcium pyrophosphate deposition disease. Calcium pyrophosphate deposition disease (CPDD) is divided into several ...
Cells were washed until the supernatant did not contain radioisotope (five washes). Pellets were then resuspended in 0.5 ml of ... Calcium Carbonate Precipitation.. After ≈2 weeks in culture, calcium carbonate-like particles, ranging in size from 20 to 100 ... For example, both calcium carbonate precipitation in coral skeleton and calcium phosphate precipitation in bone result from ... which facilitates controlled deposition of a calcium carbonate skeleton; and (iii) the calcium carbonate skeleton itself, which ...
I was also lacking in calcium on days when I did not consume both yogurt and cheese. Zinc low on days I had no red meat… Im ... A letter from the Japanese radio isotope study looking at Japanese iodine intake says. http://www.liebertonline.com/doi/abs/ ... Another example is calcium. The RDA of 1000mcg/day is not based on vit D sufficient people - which makes sense because its ... I supplement with 10,000 U vit A 3x a week, 1.25mg (50,000U) Vit 1x a week and Im looking for a good source of calcium, ...
The radioisotope is administered intravenously and localizes, like calcium, in th ... The radioisotope is administered intravenously and localizes, like calcium, in the myocardium (heart muscle). ... A scintillation camera produces an image of the distribution of the radioisotope. Areas of inadequate perfusion (blood flow) ... This is a scintillation scan (gamma camera or photoscan) involving the use of thallium-201, a radioisotope. ...
take homeopathic medicines such as calcium phosphate and symphytum. *ask your practitioner about use of magnets over the site ... Objectively - by further investigations via special scans such as radio-isotope bone scan, CT or MRI scanning. ...
Xofigo® is an alpha-particle emitting radio isotope [radium-223 dichloride]. The drug mimics calcium and forms complexes with ... are some radionuclides that are bone seeking radioisotopes and those radionuclides exhibit chemical behavior similar to calcium ... Once in the bone, the radioisotope emits beta or alpha particles, which kill the nearby cancer cells. ...
Multi-mode Handheld Radioisotope Identification Instrument SBC: Endectra LLC Topic: DTRA152007 Handheld radioisotope ... Laser Sensor for Unattended, and Precise Determination of Calcium and Strontium in Seawater SBC: CHEMLED TECHNOLOGIES, LLC ... Radioisotopes can be identified by the emission of neutrons & gammas having characteristic energies.Most hand-held radioisotope ... Multi-mode Handheld Radioisotope Identification Instrument SBC: Merrill Corporation, dba Mission Support Topic: DTRA152007 ...
Calcium Bisphosphonate Nanoparticles with Chelator-Free Radiolabeling to Deplete Tumor-Associated Macrophages for Enhanced ... Ultrasmall Hyperbranched Semiconducting Polymer Nanoparticles with Different Radioisotopes Labeling for Cancer Theranostics. ...
HAPS Objective: C01.02 Compare and contrast the terms ions, electrolytes, free radicals, isotopes and radioisotopes. HAPS Topic ... The four most common elements in the body are hydrogen, carbon, calcium, and oxygen. FALSE ... isotopes and radioisotopes. HAPS Topic: Module C01 Atoms and molecules. Learning Outcome: 02.02 Section: 02.02 Topic: Atoms and ... isotopes and radioisotopes. HAPS Objective: Q03.01 Define electrolyte. HAPS Topic: Module C01 Atoms and molecules. HAPS Topic: ...
Results for argon-39 from the reaction potassium-39 (n,p), and for argon-37, from the reaction calcium-40 (n,a), seem to ... A striking similarity for contents of seven elements in lunar metal and metal from the calcium-rich achondrite Juvinas was ... Major and Trace Elements and Cosmic-Ray Produced Radioisotopes in Lunar Samples ... Major and Trace Elements and Cosmic-Ray Produced Radioisotopes in Lunar Samples ...
Another use is as a carrier of strontium-90 radioisotope in radioisotope thermoelectric generators. Greenwood, Norman N.; ... Its optical properties are intermediate to calcium fluoride and barium fluoride. Strontium fluoride is used as an optical ...
There is a section for each radioisotope with a table of radiopharmaceuticals using that radioisotope. The sections are ordered ... Calcium-47Edit. 47Ca is a beta and gamma emitter. Name Investigation Route of administration In-vitro / in-vivo Imaging / non- ... Some radioisotopes* are used in ionic or inert form without attachment to a pharmaceutical, these are also included. ... making it more useful as a therapeutic isotope for brachytherapy implant of radioisotope capsules for local treatment of ...
In the case of radioisotopes, horizons in the two cores that excess 210Pb detection limits (A.D. 1860) and the maximum for 137 ... 1976); therefore, 14C dating method cannot be used for these cores as they contain few calcium carbonates. Therefore, we used a ... 1A). For determining the depositional ages and correlation of the turbidites, radioisotopes (137Cs and excess 210Pb; McHugh et ... MST is located below the CCD; therefore, 14C dating cannot be used for these cores that contain few calcium carbonates. ...
Serum calcium and magnesium above the institutional lower limit of normal (within 14 days of registration and within 7 days of ... Creatinine clearance or radioisotope glomerular filtration rate (GFR) ,= 70 ml/min/1.73m^2 or a serum creatinine based on age ...
Several radioisotopes of strontium, for example, are recognized as analogs of calcium and incorporated within Micrococcus ... Radioisotopes can be transformed directly through changes in valence state by acting as acceptors or by acting as cofactors to ... The radioisotope interact with binding sites of metabolically active cells and is used as terminal electron acceptor in the ... Moreover, in groundwater abound radius radioisotopes such as radium-226 and radium-228 (228Ra). They are also habitual in ...
It causes health problems, as it substitutes for calcium in bone, preventing expulsion from the body. Because it is a long- ... 89Sr is an artificial radioisotope used in treatment of bone cancer. In circumstances where cancer patients have widespread and ... Because strontium has an electron configuration similar to that of calcium, it readily substitutes for Ca in minerals. ...
Once in the body, Sr-90 acts like calcium and is readily incorporated into bones and teeth, where it can cause cancers of the ...
4. Corrected serum calcium level less than 8 mg/dL.. 5. Patients may not be receiving any other investigational agents.. 6. ... 2. Prior radioisotope treatment consisting of strontium-89 or samarium-153.. 3. Zoledronic acid treatment for more than 3 ...
  • HAPS Objective: C01.02 Compare and contrast the terms ions, electrolytes, free radicals, isotopes and radioisotopes. (issuu.com)
  • Calcium ( Ca ) has 24 isotopes, from 34 Ca to 57 Ca. There are five stable isotopes ( 40 Ca, 42 Ca, 43 Ca, 44 Ca and 46 Ca), plus one isotope ( 48 Ca ) with such a long half-life that for all practical purposes it can be considered stable. (wn.com)
  • Geochemists measure the ages of rocks by measuring the abundance of radioactive isotopes - versions of the same element that have different atomic masses - in parts of meteorites called calcium-aluminum-rich inclusions. (wired.com)
  • Radioactive tracers have many advantages over other tracers, which include the identity of chemical and physical properties of all isotopes of a given element, the emission of radiation is a specific property of the tracer which is not affected by interference from other materials in the system, radioisotopes are measurable with high sensitivity and therefore detectable in very low concentration and the measurement in situ is possible. (thefreedictionary.com)
  • and ( iii ) the calcium carbonate skeleton itself, which provides the structural support for the 3D organization of coral colonies. (pnas.org)
  • Many corals also precipitate calcium carbonate in the form of aragonite on a skeletal organic matrix (SOM) template ( 4 , 5 ). (pnas.org)
  • The basic cellular processes responsible for the production of ECM, SOM, and calcium carbonate skeleton remain largely unknown. (pnas.org)
  • By using this system, we examined the production of ECM, SOM, and calcium carbonate particles, which are the fundamental components that form the structure of the coral colony in nature. (pnas.org)
  • Extracellular production of organic matrices and calcium carbonate particles was examined in primary, nondividing cell cultures of the soft coral Xenia elongata and the stony coral Montipora digitata . (pnas.org)
  • It frequently serves as an alloying agent for other metals like aluminum and beryllium industrial materials like cement and mortar are composed of calcium compounds like calcium carbonate . (americanelements.com)
  • Effects of proton pump inhibitors on calcium carbonate absorption in women: a randomized crossover trial. (nih.gov)
  • New tests on the rock and calcium carbonate that formed over parts of the ochre show that they were painted 65,000 years ago. (kcur.org)
  • Activation of G q /11 through the heteromer increases levels of calcium/calmodulin-dependent protein kinase IIα in the nucleus accumbens, unlike activation of G s /olf-coupled D1 receptors, indicating a mechanism by which D1-D2 dopamine receptor complexes may contribute to synaptic plasticity. (pnas.org)
  • The complex was more readily detected in older mice and could modulate levels of calcium/calmodulin-dependent protein kinase IIα (CaMKIIα) in the nucleus accumbens, indicating a potential role for the D1-D2 heteromer in synaptic plasticity in the postadolescent brain. (pnas.org)
  • Results for argon-39 from the reaction potassium-39 (n,p), and for argon-37, from the reaction calcium-40 (n,a), seem to require a neutron spectrum conitaining more neutrons below 2 million electronvolts than the evaporation spectrum or that given by Arnold, Honda, and Lal (1) or a strong time dependence for the neutron flux. (sciencemag.org)
  • If your body lacks calcium, potassium and other nutrients, it will more readily absorb the radioactive elements that are similar in structure to these nutrients. (safespaceprotection.com)
  • A special facility exists for making time resolved intracellular calcium measurements. (gatech.edu)
  • We demonstrate a heteromeric D1-D2 dopamine receptor signaling complex in brain that is coupled to G q /11 and requires agonist binding to both receptors for G protein activation and intracellular calcium release. (pnas.org)
  • There have been reports, however, of a D1-like receptor in brain that is coupled to G q /11, stimulating phospholipase C (PLC) and intracellular calcium release ( 2 - 5 ). (pnas.org)
  • We have shown that heterologously coexpressed D1 and D2 dopamine receptors formed heterooligomers ( 7 ) and that coactivation of these receptors resulted in a PLC-dependent rise in intracellular calcium ( 6 ). (pnas.org)
  • The laboratory includes a basic cell culture facility, a fluorescence microscope room, instrumentation for 2D electrophoresis and for horizontal and vertical lectrophoresis using agarose and SDS PAGE gels, northern and western blotting, an ultracentrifuge for cell fractionation, a spectrophotometer, and the necessary instrumentation to do radioisotope measurements. (gatech.edu)
  • Proton and calcium transport activities in the fraction were characterized by fluorescence microscopy and spectrophotometric methods using acridine orange and arsenazo III, respectively. (jove.com)
  • A radionuclide ( radioactive nuclide , radioisotope or radioactive isotope ) is an atom that has excess nuclear energy, making it unstable. (wikipedia.org)
  • The study was done to test the ability to predict the extent of angiographically determined coronary artery disease (CAD) by quantification of coronary calcium using electron-beam computed tomography (EBCT) and to compare it with more conventional parameters for delineating the angiographic extent of CAD, that is, cardiovascular risk factors and radionuclide single-photon emission computed tomography (SPECT). (nih.gov)
  • Calcium ions play an important role in the stimulation of enzyme secretion from the exocrine pancreas. (ubc.ca)
  • Dopamine release was diminished by omitting Na + or by applying peptide calcium channel blockers, indicating that nAChRs trigger release by depolarizing the nerve terminals. (jneurosci.org)
  • Pseudogout refers to the clinical entity of acute joint inflammation that occurs because of an inflammatory response to deposited calcium-containing crystals. (psychiatryadvisor.com)
  • While calcium crystals are necessary for an attack of pseudogout to occur, some joints with pseudogout may lack enough chondrocalcinosis be detectable on plain radiographs. (psychiatryadvisor.com)
  • Some radioisotopes* are used in ionic or inert form without attachment to a pharmaceutical, these are also included. (wikipedia.org)
  • it is intimately linked to the regulation of calcium levels, carbohydrate, lipid and acid-base metabolism. (thefreedictionary.com)
  • Unlike other sorbents, alginates bind in the human body toxic metals without disturbing the calcium metabolism. (pharmocean.ru)
  • It has been proposed heretofore to incorporate radioisotopes into the structure of synthetic resins, and articles containing tritium or carbon 14 incorporated into the structure of synthetic resins or plastics have been produced. (google.com)
  • This insight informed a candidate gene approach which led to the identification of plant like calcium dependent protein kinase (CDPK) involved in egress 9 . (jove.com)
  • The role of the calcium binding protein, calmodulin in enzyme secretion was studied indirectly by determining the effects of calmodulin antagonists on the secretory process. (ubc.ca)
  • Positron Emission Tomography (PET/CT) is a diagnostic tool that uses radioisotopes to image the body's biochemical functions, detecting the presence, recurrence or spread of various types of cancer. (svmh.com)
  • To test whether the uranium ratio really was constant, Brennecka and colleagues took samples from calcium-aluminum-rich inclusions in the well-studied Allende meteorite and measured how much uranium-235 and uranium-238 they held. (wired.com)
  • Acidocalcisomes are acidic calcium stores found in diverse organisms, being conserved from bacteria to humans. (jove.com)
  • These studies indicate the possibility that phenothiazines inhibit calcium-mediated amylase release from pancreatic acinar cells by acting on a calmodulin-regulated step in the stimulus-secretion coupling process. (ubc.ca)
  • We examined calcium signaling through D1 and D2 dopamine receptors that were stably coexpressed in human embryonic kidney cells (D1-D2 HEK cells). (pnas.org)
  • Because treatment of D1-D2 HEK cells or D2 HEK cells with quinpirole alone did not stimulate calcium release (data not shown), calcium release appeared to depend on coordinated activation of both D1 and D2 receptors. (pnas.org)