AnatomyDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and Processes
Calcium PyrophosphateChondrocalcinosisDiphosphatesMicroscopy, PolarizationCrystallizationScleral DiseasesCalcium PhosphatesSynovial FluidPhosphate Transport ProteinsGoutPyrophosphatasesUric AcidTetramisoleCalcinosisJoint DiseasesOsteoarthritisDurapatiteKnee JointThiamine PyrophosphateCartilage, ArticularArthritisHydroxyapatitesTechnetium Tc 99m PyrophosphateCalcium SignalingPolyisoprenyl PhosphatesPhosphoribosyl PyrophosphateMenisci, TibialArthroscopyKnee InjuriesRotator CuffTearsAnterior Cruciate LigamentFractures, Cartilage
Calcium Pyrophosphate
An inorganic pyrophosphate which affects calcium metabolism in mammals. Abnormalities in its metabolism occur in some human diseases, notably HYPOPHOSPHATASIA and pseudogout (CHONDROCALCINOSIS).
Chondrocalcinosis
Presence of calcium salts, especially calcium pyrophosphate, in the cartilaginous structures of one or more joints. When accompanied by attacks of goutlike symptoms, it is called pseudogout. (Dorland, 27th ed)
Diphosphates
Inorganic salts of phosphoric acid that contain two phosphate groups.
Microscopy, Polarization
Microscopy using polarized light in which phenomena due to the preferential orientation of optical properties with respect to the vibration plane of the polarized light are made visible and correlated parameters are made measurable.
Crystallization
The formation of crystalline substances from solutions or melts. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Scleral Diseases
General disorders of the sclera or white of the eye. They may include anatomic, embryologic, degenerative, or pigmentation defects.
Calcium Phosphates
Calcium salts of phosphoric acid. These compounds are frequently used as calcium supplements.
Synovial Fluid
The clear, viscous fluid secreted by the SYNOVIAL MEMBRANE. It contains mucin, albumin, fat, and mineral salts and serves to lubricate joints.
Phosphate Transport Proteins
Membrane proteins that are involved in the active transport of phosphate.
Gout
Hereditary metabolic disorder characterized by recurrent acute arthritis, hyperuricemia and deposition of sodium urate in and around the joints, sometimes with formation of uric acid calculi.
Pyrophosphatases
A group of enzymes within the class EC 3.6.1.- that catalyze the hydrolysis of diphosphate bonds, chiefly in nucleoside di- and triphosphates. They may liberate either a mono- or diphosphate. EC 3.6.1.-.
Uric Acid
An oxidation product, via XANTHINE OXIDASE, of oxypurines such as XANTHINE and HYPOXANTHINE. It is the final oxidation product of purine catabolism in humans and primates, whereas in most other mammals URATE OXIDASE further oxidizes it to ALLANTOIN.
Tetramisole
Calcinosis
Pathologic deposition of calcium salts in tissues.
Joint Diseases
Osteoarthritis
A progressive, degenerative joint disease, the most common form of arthritis, especially in older persons. The disease is thought to result not from the aging process but from biochemical changes and biomechanical stresses affecting articular cartilage. In the foreign literature it is often called osteoarthrosis deformans.
Durapatite
The mineral component of bones and teeth; it has been used therapeutically as a prosthetic aid and in the prevention and treatment of osteoporosis.
Knee Joint
A synovial hinge connection formed between the bones of the FEMUR; TIBIA; and PATELLA.
Thiamine Pyrophosphate
The coenzyme form of Vitamin B1 present in many animal tissues. It is a required intermediate in the PYRUVATE DEHYDROGENASE COMPLEX and the KETOGLUTARATE DEHYDROGENASE COMPLEX.
Cartilage, Articular
A protective layer of firm, flexible cartilage over the articulating ends of bones. It provides a smooth surface for joint movement, protecting the ends of long bones from wear at points of contact.
Arthritis
Hydroxyapatites
A group of compounds with the general formula M10(PO4)6(OH)2, where M is barium, strontium, or calcium. The compounds are the principal mineral in phosphorite deposits, biological tissue, human bones, and teeth. They are also used as an anticaking agent and polymer catalysts. (Grant & Hackh's Chemical Dictionary, 5th ed)
Technetium Tc 99m Pyrophosphate
A radionuclide imaging agent used primarily in scintigraphy or tomography of the heart to evaluate the extent of the necrotic myocardial process. It has also been used in noninvasive tests for the distribution of organ involvement in different types of amyloidosis and for the evaluation of muscle necrosis in the extremities.
Calcium Signaling
Signal transduction mechanisms whereby calcium mobilization (from outside the cell or from intracellular storage pools) to the cytoplasm is triggered by external stimuli. Calcium signals are often seen to propagate as waves, oscillations, spikes, sparks, or puffs. The calcium acts as an intracellular messenger by activating calcium-responsive proteins.
Polyisoprenyl Phosphates
Phosphoric or pyrophosphoric acid esters of polyisoprenoids.
Phosphoribosyl Pyrophosphate
The key substance in the biosynthesis of histidine, tryptophan, and purine and pyrimidine nucleotides.
Menisci, Tibial
The interarticular fibrocartilages of the superior surface of the tibia.
Arthroscopy
Endoscopic examination, therapy and surgery of the joint.
Knee Injuries
Injuries to the knee or the knee joint.
Rotator Cuff
The musculotendinous sheath formed by the supraspinatus, infraspinatus, subscapularis, and teres minor muscles. These help stabilize the head of the HUMERUS in the glenoid fossa and allow for rotation of the SHOULDER JOINT about its longitudinal axis.
Tears
The fluid secreted by the lacrimal glands. This fluid moistens the CONJUNCTIVA and CORNEA.
Anterior Cruciate Ligament
A strong ligament of the knee that originates from the posteromedial portion of the lateral condyle of the femur, passes anteriorly and inferiorly between the condyles, and attaches to the depression in front of the intercondylar eminence of the tibia.
Fractures, Cartilage
Breaks in CARTILAGE.

Transduction mechanisms of porcine chondrocyte inorganic pyrophosphate elaboration. (1/116)

OBJECTIVE: To investigate cellular signaling mechanisms that influence chondrocyte production of inorganic pyrophosphate (PPi), which promotes calcium pyrophosphate dihydrate (CPPD) crystal deposition. METHODS: Articular chondrocyte and cartilage cultures were stimulated with protein kinase C (PKC) activator and adenyl cyclase activator. Generation of extracellular PPi was measured. RESULTS: Adenyl cyclase activation resulted in diminished pyrophosphate generation. PKC activation stimulated pyrophosphate elaboration. CONCLUSION: Two signaling pathways, cAMP and PKC, modulate generation of extracellular pyrophosphate by cartilage and chondrocytes. They are novel targets for potentially diminishing extracellular pyrophosphate elaboration that leads to CPPD crystal deposition.  (+info)

Myelopathy due to calcification of the cervical ligamenta flava: a report of two cases in West Indian patients. (2/116)

Two cases of cervical myelopathy due to calcification of the ligamenta flava (CLF) are described for the first time in black patients from the French West Indies. A pre-operative CT scan differentiated the diagnosis from one of ossification of the ligamenta flava. Microanalysis on the operatively excised specimen in one patient revealed a mixture of calcium pyrophosphate dihydrate crystals and hydroxypatite crystals. Poor outcome in one patient contrasting with excellent recovery in the other one, who had undergone posterior decompressive laminectomy, emphasizes the importance of surgery in the management of CLF.  (+info)

Most calcium pyrophosphate crystals appear as non-birefringent. (3/116)

OBJECTIVE: To determine the proportion of calcium pyrophosphate dihydrate (CPPD) crystals that appear as non-birefringent when observed under the polarised light microscope. METHODS: Two observers examined independently 10 synovial fluid samples obtained during an episode of arthritis attributable to CPPD crystals. Ten synovial fluid samples from patients with acute gout were used as a reference. The examination was performed after placing a fluid sample in a Niebauer haemocytometric chamber; a crystal count was done first under ordinary light, then in the area corresponding to a 0.1 ml, under polarised light RESULTS: The percentages of birefringence appreciated for CPPD were 18% (confidence intervals (CI) 12, 24) for observer 1, and 17% (CI 10, 24) for observer 2 (difference NS). The percentages of birefringence for monosodium urate were 127% (CI 103, 151) for observer 1 and 107% (CI 100, 114) for observer 2 (difference NS). Percentages above 100% indicate that crystals missed under ordinary light became apparent under polarised light. CONCLUSION: Only about one fifth of all CPPD crystals identified by bright field microscopy show birefringence when the same synovial fluid sample is observed under polarised light. If a search for CPPD crystals is conducted under polarised light, the majority of the crystals will be missed. Ordinary light allows a better rate of CPPD crystal detection but observation under polarised light of crystals showing birefringence is required for definitive CPPD crystal identification.  (+info)

Extracellular signal-regulated kinase 1/extracellular signal-regulated kinase 2 mitogen-activated protein kinase signaling and activation of activator protein 1 and nuclear factor kappaB transcription factors play central roles in interleukin-8 expression stimulated by monosodium urate monohydrate and calcium pyrophosphate crystals in monocytic cells. (4/116)

OBJECTIVE: Monosodium urate monohydrate (MSU) and calcium pyrophosphate dihydrate (CPPD) crystals cause acute gout and pseudogout, respectively. Because acute gout and pseudogout appear to be dependent on interleukin-8 (IL-8)-induced neutrophil ingress, this study was undertaken to define and compare how MSU and CPPD crystals stimulate IL-8 messenger RNA (mRNA) expression in mononuclear phagocytes. METHODS: MSU and CPPD crystal-induced mitogen-activated protein kinase (MAPK) signal transduction and IL-8 transcriptional activation were studied in human monocytic cells, using the THP-1 cell line. RESULTS: MSU and CPPD crystals (0.5 mg/ml) induced activation of c-Jun N-terminal kinase, extracellular signal-regulated kinase 1 (ERK-1)/ERK-2, and p38 MAPK pathways in THP-1 cells. Activation of the ERK-1/ERK-2 pathway was essential for MSU and CPPD crystal-induced IL-8 mRNA expression, whereas the p38 pathway played a greater role in IL-8 mRNA expression in response to CPPD crystals in comparison with MSU crystals. Both crystals induced the binding of nuclear factor kappaB (NF-kappaB), including the NF-kappaB complex c-Rel/RelA, and activator protein 1 (AP-1, including N-terminal phosphorylated c-Jun) to the IL-8 promoter. Both crystals induced transcriptional activation of the IL-8 promoter, which was dependent on activation of c-Rel/RelA and AP-1. Activation of the NF-IL-6 transcription factor played a lesser role. Finally, crystal-induced IL-8 promoter activation was mediated by activation of the ERK-1/ERK-2 pathway, as demonstrated by transfection of dominant-negative raf-1. CONCLUSION: These results indicate that ERK-1/ ERK-2 signaling and transcriptional activation through AP-1 and NF-kappaB are essential for the induction of IL-8 expression in mononuclear phagocytes in response to CPPD and MSU crystals.  (+info)

Calcification of the cervical ligamentum flavum--case report. (5/116)

A 52-year-old male presented with calcification of the cervical ligamentum flavum manifesting as hypesthesia of the bilateral middle, ring, and little fingers and ulnar halves of both forearms, as well as motor weakness in the bilateral upper extremities and gait disturbance. Cervical x-ray tomography detected a round calcified mass on the posterior wall of the cervical canal at the C-5 level. Computed tomography showed the round, nodular calcified mass more clearly. Magnetic resonance imaging showed an epidural low intensity mass compressing and distorting the cervical cord at the C-5 level on both T1- and T2-weighted images. Administration of gadolinium-diethylenetriaminepenta-acetic acid caused marginal enhancement of the mass. The lesion was eventually removed by posterior laminectomy. The mass was composed of a very hard crystal-like calcified deposition in the ligamentum flavum. X-ray diffraction analysis of the histological specimen showed calcium pyrophosphate dihydrate (CPPD) and hydroxyapatite in the crystal-like substance, confirming that CPPD is responsible for calcification of the cervical ligamentum flavum.  (+info)

Deposition of calcium pyrophosphate in tissue after revision arthroplasty of the hip. (6/116)

We reviewed histologically the incidence and pathogenesis of the deposition of calcium pyrophosphate dihydrate (CPPD) crystals in the pseudocapsule, femoral and acetabular membranes and periprosthetic tissue at revision of 789 cases of failed total hip replacement. In 13, periprosthetic tissues were found to have deposits of CPPD crystals in areas of cartilaginous metaplasia; four also showed evidence of localised deposition of amyloid. None of the patients had a history of chondrocalcinosis in the hip or other joints. Cartilaginous metaplasia and other changes in periprosthetic tissues may predispose to the deposition of CPPD and associated localised amyloid.  (+info)

Retro-odontoid massive calcium pyrophosphate crystal deposition--case report. (7/116)

An 86-year-old male presented with progressive myelopathy due to retro-odontoid massive deposits of calcium pyrophosphate dihydrate (CPPD) crystals. Magnetic resonance imaging revealed a non-enhanced isointense extradural mass on the T1-weighted image and heterogeneously intense mass on the T2-weighted image. Computed tomography showed typical punctate and linear calcifications within the mass. The mass was resected via a lateral approach resulting in marked improvement of the symptoms. Histological examination revealed birefringent rhomboid crystals consistent with CPPD. CPPD deposition should be considered in the differential diagnosis of retro-odontoid extradural mass because surgical therapy is beneficial even for elderly patients.  (+info)

Inhibition of TNF-alpha-induced neutrophil apoptosis by crystals of calcium pyrophosphate dihydrate is mediated by the extracellular signal-regulated kinase and phosphatidylinositol 3-kinase/Akt pathways up-stream of caspase 3. (8/116)

The role of protein kinases in the inhibition of TNF-alpha associated apoptosis of human neutrophils by crystals of calcium pyrophosphate dihydrate (CPPD) (25 mg/ml) was investigated. We monitored the activities of the p44 extracellular signal-regulated kinase 1 (ERK1) and p42 ERK2 mitogen-activated protein (MAP) kinases and phosphatidylinositol 3-kinase (PI3-K)-regulated protein kinase B (Akt) in neutrophils incubated with TNF-alpha and CPPD crystals, separately and in combination, in parallel with the endogenous caspase 3 activity and DNA fragmentation. CPPD crystals were observed to induce a robust and transient activation of ERK1, ERK2, and Akt, whereas TNF-alpha produced only a modest and delayed activation of Akt. In the presence of TNF-alpha, Akt activity was enhanced, and CPPD crystal-induced activation of ERK1 and ERK2 was more sustained than with CPPD crystals alone, but TNF-alpha itself reduced the basal phosphotransferase activities of these MAP kinases. Preincubation with the MAP kinase kinase (MEK1) inhibitors PD98059 (20 ng/ml) and U0126 (250 nM), or the PI3-K inhibitors wortmannin (100 nM) and LY294002 (50 microM) repressed the activation of ERK1, ERK2, and Akt in association with CPPD crystal incubation, in the absence or presence of TNF-alpha. Furthermore, the inhibition of the Mek1/Mek2-->ERK1/ERK2 or PI3-K/Akt pathways reversed CPPD crystal-associated suppression of TNF-alpha-induced caspase 3 activation and neutrophil apoptosis. Together, these results indicate that CPPD crystals function to induce acute inflammatory responses through ERK1/ERK2 and PI3-K/Akt-mediated stimulation of neutrophil activation and repression of apoptosis.  (+info)

Calcium Pyrophosphate Dihydrate Deposition Disease | Medical City DallasCalcium Pyrophosphate Dihydrate Deposition Disease | Medical City Dallas
Learn more about Calcium Pyrophosphate Dihydrate Deposition Disease at Medical City Dallas DefinitionCausesRisk FactorsSymptomsDiagnosisTreatmentPreventionrevision ...
https://medicalcityhospital.com/hl/?/100261/Calcium-pyrophosphate-deposition-disease&com.dotmarketing.htmlpage.language=1
Treatment of calcium pyrophosphate crystal deposition (CPPD) diseaseTreatment of calcium pyrophosphate crystal deposition (CPPD) disease
Precipitation of crystals of calcium pyrophosphate dihydrate (CPP) in connective tissues may be asymptomatic or may be associated with several clinical syndromes. These disorders, including acute inflammatory, chronic inflammatory, and degenerative a
http://www.uptodate.com/contents/treatment-of-calcium-pyrophosphate-crystal-deposition-cppd-disease
Chronic calcium pyrophosphate crystal inflammatory arthritis induced by extreme hypomagnesemia in short bowel syndrome | BMC...Chronic calcium pyrophosphate crystal inflammatory arthritis induced by extreme hypomagnesemia in short bowel syndrome | BMC...
Mg is a divalent cation mostly located intracellularly. It plays an important role in enzymatic processes. In healthy individuals homeostasis of Mg is regulated effectively, as sufficient mechanisms in the gastrointestinal tract and the kidney exist. However, if these mechanisms are affected in underlying disease, Mg depletion can cause a wide range of symptoms such as neuromuscular manifestations (muscular cramps, vertigo, tetany), cardiac and vascular manifestations (arrhythmias, hypertension), metabolic sequels and psychiatric manifestations (depression, fatigue) [11, 12].. As seen in this case, severe Mg depletion resulted in CPPD deposition with clinical manifestations of chronic inflammatory arthritis [13-16] and was responsible for muscular weakness, fatigue and the depressive episode.. Chondrocalcinosis, is defined as the deposition of calcium pyrophosphate dihydrate in hyaline or fibrous cartilage [14]. In radiography delicate linear calcification of the cartilage can be seen. The ...
https://bmcgastroenterol.biomedcentral.com/articles/10.1186/1471-230X-12-129
Calcium Pyrophosphate Deposition Disease
Calcium deposition is often seen at the triangular fibrocartilage of the wrist. Subchondral sclerosis, joint space narrowing, subchondral cyst formations which may be quite large, and intraarticular bodies from subchondral osseous collapse and fragmentation are all findings which can be seen in patients with CPPD disease. These radiographic abnormalities are most common at the radiocarpal articulation and at the 2nd and 3rd metacarpophalangeal joints. Additionally, there may a shift in the normal alignment of the scaphoid and lunate and narrowing at the midcarpal compartment. Differential Diagnosis:. CPPD disease causes destruction of cartilage which can lead to radiographic findings similar to osteoarthritis. Sites of involvement are useful for differentiating the two since the radiocarpal compartment of the wrist is not a common location for osteoarthritis. Lack of an erosive process at the MCP joint differentiates CPPD crystal deposition disease from rheumatoid arthritis. Greater propensity ...
http://gentili.net/Hand/CPPD.htm
Milwaukee shoulder syndrome - WikipediaMilwaukee shoulder syndrome - Wikipedia
Milwaukee shoulder syndrome (apatite-associated destructive arthritis) is a rheumatological condition similar to calcium pyrophosphate dihydrate deposition disease (CPPD). It is associated with periarticular or intraarticular deposition of hydroxyapatite crystals. Crystal deposition in the joint causes the release of collagenases, serine proteases, elastases, and interleukin-1. This precipitates acute and rapid decline in joint function and degradation of joint anatomy. Subsequently disruption of the rotator cuff ensues. Along with symptomatology, the disease typically presents with positive radiologic findings, often showing marked erosion of the humeral head, cartilage, capsule, and bursae. Though rare, it is most often seen in females beginning in their 50s or 60s. Diagnosis is made with arthrocentesis and Alizarin Red staining along with clinical symptoms. Signs and symptoms may include the following: Limited active range of motion, usually unrestricted passive range of movement (early) ...
https://en.wikipedia.org/wiki/Milwaukee_shoulder_syndrome
Angiomyolipoma | eHealth.me
Support group for people who have Angiomyolipoma and experience Calcium Pyrophosphate Dihydrate Deposition Disease, created by eHealthMe (http://www.eHealthMe.com). To join the group, do any of these: create a post to introduce yourself, ask a question, or simply follow the group.. submitted on 6 months 1 week ago by eHealthMe.com ...
https://ehealth.me/topics/angiomyolipoma
Inflammatory microcrystals induce murine macrophage survival and DNA synthesis | Arthritis Research & Therapy | Full TextInflammatory microcrystals induce murine macrophage survival and DNA synthesis | Arthritis Research & Therapy | Full Text
The interaction of particulates with resident macrophages is a consistent feature in certain forms of crystal-induced inflammation, for example, in synovial tissues, lung, and the peritoneum. The mitogenic activity of basic calcium phosphate (BCP) crystals and calcium pyrophosphate dihydrate (CPPD) crystals on synovial fibroblasts has been considered relevant to the synovial hyperplasia observed in crystal-induced arthritis. The aim of the study was to determine whether microcrystals such as these could enhance macrophage survival and induce DNA synthesis, thus indicating that they may contribute to the tissue hyperplasia. Murine bone-marrow-derived macrophages were treated in vitro with microcrystals, the cell numbers were monitored over time, and DNA synthesis was measured as the incorporation of [methyl-3H]thymidine (TdR). We report here that BCP, monosodium urate, talc, and, to a lesser extent, CPPD crystals promote macrophage survival and DNA synthesis; the latter response is particularly striking
https://arthritis-research.biomedcentral.com/articles/10.1186/ar308/email/correspondent/c1/new
Identification of calcium pyrophosphate deposition disease (CPPD) by ultrasound: reliability of the OMERACT definitions in an...Identification of calcium pyrophosphate deposition disease (CPPD) by ultrasound: reliability of the OMERACT definitions in an...
Methods A web-based exercise and subsequent patient-based exercise were carried out. A panel of 30 OMERACT members, participated at the web-based exercise by evaluating twice a set of US images for the presence/absence of CPPD. Afterwards, 19 members of the panel met in Siena, Italy, for the patient-based exercise. During the exercise, all sonographers examined twice eight patients for the presence/absence of CPPD at the same joints. Intraoberserver and interobserver kappa values were calculated for both exercises. ...
https://ard.bmj.com/content/77/8/1194
Arthritis Associated with Systemic Disease, and Other Arthritides | Harrisons Principles of Internal Medicine, 19e |...Arthritis Associated with Systemic Disease, and Other Arthritides | Harrisons Principles of Internal Medicine, 19e |...
Osteoarthritis is a common feature, most often affecting the knees, shoulders, hips, and hands. Single or multiple joints may be affected. Hypertrophy of cartilage initially produces radiographic widening of the joint space. The newly synthesized cartilage is abnormally susceptible to fissuring, ulceration, and destruction. Ligamental laxity of joints further contributes to the development of osteoarthritis. Cartilage degrades, the joint space narrows, and subchondral sclerosis and osteophytes develop. Joint examination reveals crepitus and laxity. Joint fluid is noninflammatory. Calcium pyrophosphate dihydrate crystals are found in the cartilage in some cases of acromegaly arthropathy and, when shed into the joint, can elicit attacks of pseudogout. Chondrocalcinosis may be observed on radiographs. Back pain is extremely common, perhaps as a result of spine hypermobility. Spine radiographs show normal or widened intervertebral disk spaces, hypertrophic anterior osteophytes, and ligamental ...
http://accessmedicine.mhmedical.com/content.aspx?bookid=1130&Sectionid=79751209
Articular cartilage in the degenerative arthropathy of hemochromatosis. - Semantic ScholarArticular cartilage in the degenerative arthropathy of hemochromatosis. - Semantic Scholar
Iron was readily demonstrated in chondrocytes in 3 of 4 hemochromatosis articular cartilages studied. Either apatite, calcium pyrophosphate dihydrate crystals, or both were found in all cartilages including those of 3 patients who had no radiographic or light microscopic evidence of calcification. These crystals, which may be secondary to degenerative changes or may play a role in cartilage degeneration, were not seen in any consistent morphologic relationship with the iron deposits. In fact, apatite was found in one cartilage in which no iron was identified in the sections studied. If iron, as demonstrated in the chondrocytes, is contributing to the calcium crystal deposition, it would most likely do so indirectly, for example by altering chondrocyte enzymes or connective tissue components.
https://www.semanticscholar.org/paper/Articular-cartilage-in-the-degenerative-arthropath-Schumacher/6c659cf2fe65cf1e904ed8299961390ef90b9728
Calcium Pyrophosphate Arthritis - Bone, Joint, and Muscle Disorders - MSD Manual Consumer VersionCalcium Pyrophosphate Arthritis - Bone, Joint, and Muscle Disorders - MSD Manual Consumer Version
Calcium Pyrophosphate Arthritis - Learn about the causes, symptoms, diagnosis & treatment from the MSD Manuals - Medical Consumer Version.
https://www.msdmanuals.com/en-sg/home/bone,-joint,-and-muscle-disorders/gout-and-calcium-pyrophosphate-arthritis/calcium-pyrophosphate-arthritis
Calcium Pyrophosphate Arthritis - Musculoskeletal and Connective Tissue Disorders - Merck Manuals Professional EditionCalcium Pyrophosphate Arthritis - Musculoskeletal and Connective Tissue Disorders - Merck Manuals Professional Edition
Calcium Pyrophosphate Arthritis - Etiology, pathophysiology, symptoms, signs, diagnosis & prognosis from the Merck Manuals - Medical Professional Version.
https://www.merckmanuals.com/professional/musculoskeletal-and-connective-tissue-disorders/crystal-induced-arthritides/calcium-pyrophosphate-arthritis
Formation Product of Calcium Pyrophosphate Crystals in Vitro and the Effect of Iron Salts | Clinical ScienceFormation Product of Calcium Pyrophosphate Crystals in Vitro and the Effect of Iron Salts | Clinical Science
Thank you for your interest in spreading the word about Clinical Science.. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.. ...
http://www.clinsci.org/content/54/2/29P.1
Plus itPlus it
OBJECTIVE: To evaluate the ability of baseline hand radiographs to predict the diagnosis 2 years later in a cohort of patients with early arthritis. METHODS: A total of 258 patients with arthritis onset within the previous year were evaluated. At baseline, all patients underwent a standardized evaluation including laboratory tests and radiographs. Hand radiographs were read by a blinded observer who used a standardized procedure for detecting features of crystal deposition diseases and rheumatoid arthritis (RA). After 30 +/- 11.3 months, the final diagnosis was established by a panel of rheumatologists. All radiographs were evaluated. RESULTS: Significant associations were found between radiographic features and a clinical diagnosis of RA, calcium pyrophosphate dihydrate (CPPD) arthritis, and hydroxyapatite arthritis. No radiographic abnormalities suggesting psoriatic arthritis or gout were seen. The sensitivities of hand radiographs for diagnosing CPPD or hydroxyapatite arthritis ranged from ...
https://www.jrheum.org/content/33/8/1511
What is the basic treatment for pseudogout, and what medications are prescribed for it? | Reference.comWhat is the basic treatment for pseudogout, and what medications are prescribed for it? | Reference.com
Psuedogout, also referred to as calcium pyrophosphate deposition disease, or CPDD, is a form of arthritis caused by crystal deposits in joints. The American College of Rheumatology states there is no...
https://www.reference.com/health/basic-treatment-pseudogout-medications-prescribed-39dfde6e89787e52
SAC & ArthritisSAC & Arthritis
Rheumatoid Arthritis is an auto-immune disease in which our immune system mistakenly attacks healthy joint tissue. It causes swelling, pain and eventually joint deformities. The inflammation can spread to the surrounding tissues and damage cartilage and bones. About 21 million people are affected by this disease globally each year.. Gout & Calcium Pyrophosphate Deposition Disease (CPPD) are caused by excess uric acid and calcium salt respectively, forming crystals in joints and causing inflammation, redness and swelling. Causes are unclear, but the risk increases with age and the disease is often misdiagnosed as arthritis. ...
https://www.marahnaturalusa.com/sac-arthritis
Calcium Pyrophosphate Dehydrate Deposition DiseaseCalcium Pyrophosphate Dehydrate Deposition Disease
Pain is an unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage
http://pain.dieutridau.com/rehabilitation/assessment/imaging/musculoskeletal/4575-calcium-pyrophosphate-dehydrate-deposition-disease
Barium Iodide Dihydrate in India, Barium Iodide Dihydrate Products, Barium Iodide Dihydrate Suppliers in India, Barium Iodide...Barium Iodide Dihydrate in India, Barium Iodide Dihydrate Products, Barium Iodide Dihydrate Suppliers in India, Barium Iodide...
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http://indiayellowpagesonline.in/chemicals/barium-iodide-dihydrate.htm
Association between synovial fluid levels of inorganic pyrophosphate and short term radiographic outcome of knee osteoarthritis...Association between synovial fluid levels of inorganic pyrophosphate and short term radiographic outcome of knee osteoarthritis...
OBJECTIVE: To test the hypothesis that high concentrations of extracellular inorganic pyrophosphate (PPi), which associate with increased cell synthesis and turnover in cartilage, may act as a marker for structural outcome in knee osteoarthritis (OA). METHOD: One hundred and thirty five consecutive patients referred to hospital with knee OA (59 men, 76 women; mean age 71 years, range 41-88) were followed prospectively for a median of 2.5 years (interquartile range 1.75-3.0). Synovial fluid (SF) aspirated at presentation (202 OA knees: 68 bilateral, 66 unilateral) was assessed for PPi content by radiometric assay. Knee radiographs at presentation and at final review were assessed for change in global (Kellgren) and individual features (narrowing, osteophyte, sclerosis, cyst, attrition) of OA. RESULTS: The median SF PPi level was 10.5 mumol (range 0.07-72.4). At baseline, high PPi was significantly associated with presence of calcium pyrophosphate crystals, chondrocalcinosis, and bone attrition. ...
http://ard.bmj.com/content/55/7/432
Synthesis and Characterisation of Hydrated Calcium Pyrophosphate Phases of Biological Interest - Gras - 2013 - European Journal...Synthesis and Characterisation of Hydrated Calcium Pyrophosphate Phases of Biological Interest - Gras - 2013 - European Journal...
If you are a society or association member and require assistance with obtaining online access instructions please contact our Journal Customer Services team ...
http://onlinelibrary.wiley.com/doi/10.1002/ejic.201300955/pdf
Crystal-related arthropathies - Oxford MedicineCrystal-related arthropathies - Oxford Medicine
Many crystals have been associated with arthropathies or periarticular syndromes: only monosodium urate monohydrate (gout), calcium pyrophosphate dehydrate (pseudogout, chondrocalcinosis), and basic calcium phosphates (mainly hydroxyapatite) are common.Crystals implicated in joint disease are stable, hard particles that exert biological effects via surface-active (activation of humoral and cell-derived mediators, interaction with cell membranes) and mechanical properties. In general, smaller particle size, marked surface irregularity, and high negative surface charge correlate with inflammatory potential....
http://oxfordmedicine.com/view/10.1093/med/9780199204854.001.1/med-9780199204854-chapter-1910
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Roentgen Ray Reader: March 2012Roentgen Ray Reader: March 2012
Chronic CPP crystal inflammatory arthritis: Chronic inflammatory oligoarthritis or polyarthritis associated with CPPD. Patients have occasional systemic upset with elevation of CRP and ESR and superimposed flares with characteristics of crystal inflammation (see above). Differential considerations include rheumatoid arthritis and other chronic inflammatory joint diseases in older adults. Imaging findings are similar to those of osteoarthritis, but the dirstribution within the joint is different, with CPPD affecting non-weight-bearing surfaces of joints. It is also usually bilateral and symmetric. Synovial inflammation and joint effusions can also be seen. Osteophytes and osteochondral bodies are commonly present. Subchondral cysts are more prominent than in osteoarthritis, and may form before cartilage loss is radiographically evident. Risk factors for calcium pyrophosphate arthropathy are aging, osteoarthritis, previous joint trauma, metabolic diseases (e.g., the four Hs: hemochromatosis, ...
http://roentgenrayreader.blogspot.com/2012_03_01_archive.html
25 July 201325 July 2013
Definition It is a crystal deposition of calcium pyrophosphate dehydrate (CPPD) in cartilage (chondrocalcinosis). It is a common age associated phenomenon (|55) that particularly targets the knee . Aetiology (Causes)
https://www.med2date.com/2013/07/pyrophosphate-arthropathy.html
April, 2016 | Peter D Springberg, MD, FACP
A few months ago I rather suddenly developed an acute painful swelling at the base of my left big toe. I think Im having an attack of gout, but why me? I wondered. Of course this had to happen on a weekend, when the Family Practice Clinic Id usually go to was closed, as was my Podiatrists office.. I wondered if I could have septic arthritis, an infected joint, but had no obvious reason for this much more frightening diagnosis. I remembered there was also an entity called pseudogout, where the crystals were calcium pyrophosphate, not uric acid.. So I went to the Urgent Care Center our local hospital established a few blocks away from my house. A Family Practice physician examined me and said, I think you have gout, but youll need to go to the hospitals Emergency Department (ED) so they can get some fluid from your joint and decide if its really gout. We dont do that test here. She was also concerned about the rather slim possibility of septic arthritis.. At the ED I was triaged as ...
http://www.peterdspringbergmdfacp.com/blog/?m=201604
Plus itPlus it
Methods. This was a prospective, longitudinal, observational factorial study, analyzing 30 SF samples: 12 with monosodium urate (MSU) crystals and 18 with calcium pyrophosphate (CPP) crystals. Each SF sample was divided into 4 subsamples (120 subsamples in total). Two were stored in each type of preserving agent, heparin or ethylenediamine tetraacetic acid (EDTA), at room temperature or at 4°C. Samples were analyzed the following day (T1), at 3 days (T2), and at 7 days (T3) by simple polarized light microscopy, and the presence of crystals was recorded. ...
https://www.jrheum.org/content/47/9/1416
Sodium phosphate, dibasic dihydrate, 99+%, for HPLC, ACROS Organicsâ„¢ 100g; Glass bottle Sodium phosphate, dibasic dihydrate, 99...Sodium phosphate, dibasic dihydrate, 99+%, for HPLC, ACROS Organicsâ„¢ 100g; Glass bottle Sodium phosphate, dibasic dihydrate, 99...
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CAS # 7787-33-9, Barium diiodide dihydrate, Barium iodide dihydrateCAS # 7787-33-9, Barium diiodide dihydrate, Barium iodide dihydrate
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ST075160AC | bioactive-compounds | chemical-compoundsST075160AC | bioactive-compounds | chemical-compounds
Formula: C14H26CaO16MW: 490. 43CAS: 10030-53-2MDL NUMBER: MFCD00014340Smiles: C([[email protected]@H]([[email protected]@H]([[email protected]]([[email protected]@H]([[email protected]](O)CO)O)O)O)O)(O[Ca]OC([[email protected]@H]([[email protected]@H]([[email protected]]([[email protected]@H]([[email protected]](O)CO)O)O)O)O)=O)=OTHERAPEUTIC CATEGORY: a calcium replenisherACCEPTORS: 16DONORS: 12ROTATION BONDS: 18N+O: 16Chiral Centers: 10LogP: LogS: LIPINSKI: Synonyms: ALPHA-D-GLUCOHEPTONIC ACID CALCIUM SALT DIHYDRATE;ALPHA-D-GLUCOHEPTONIC ACID CALCIUM SALT HYDRATE;D-GLYCERO-D-GLUCOHEPTONIC ACID CALCIUM SALT DIHYDRATE;CALCIUM ALPHA-D-HEPTAGLUCONATE DIHYDRATE;CALCIUM ALPHA-D-HEPTAGLUCONATE HYDRATE;calcium a-d-heptagluconate dihydrate;a-d-glucoheptonic acid calcium salt;a-D-Glucoheptonic acid calcium salt, D-Glycero-D-glucoheptonic acid calcium salt CAS:10030-53-2 MF:C14H30CaO18 MW:526....
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Sodium 4-nitrophenolate Dihydrate | C6H8NNaO5 - PubChemSodium 4-nitrophenolate Dihydrate | C6H8NNaO5 - PubChem
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The School of Nursing and Healthcare Leadership at Minnesota State University Moorhead is proud to welcome a new member to its full time faculty. Alicia Swanson, has been teaching at MSUM part-time since the summer of 2007. Below is the message that she would like to share with all about her journey to MSUM. Warmest…
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Structure of L-Arginyl-L-aspartie Acid Dihydrate - [email protected]
C~0H~gN5Os.2H20, Mr=325.32, monoclinic,P2~, a = 12.029 (2), b=4.904 (2), c=13.215 (2) A, fl= 107.68 (2) ° , F= 743 (1) A 3, Z= 2,D m = 1-45, D x = 1.45 Mg m -3, Cu Ka, 2 = 1.54184 A,fl= 1.01mm -1, F(000)=348, T=293K. The final R value for 1277 observed reflections 110 ,_ 3tr(Io)l is 0.031. The dipeptide exists as a zwitterion. The arginyl side-chain conformation is similar to that found in arginyl-glutamic acid [Pandit, Seshadri & Viswamitra (1983). Acta Cryst. C39, 1669-16721. The guanidyl group forms a pair of hydrogen bonds with oxygen atoms of the backbone carboxyl group. The crystal structure is also stabilized by -bonding interactions involving both water molecules.. ...
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The diagnosis of calcium pyrophosphate dihydrate crystal deposition disease: the good, the bad and… ultrasonography! |...
The diagnosis of calcium pyrophosphate dihydrate crystal deposition disease (CPPD) until recent years has been mainly based on the finding of typical crystals of calcium pyrophosphate dihydrate (CPP) in the synovial fluid of affected patients and on the presence of typical calcifications on plain X-rays ...
https://www.reumatismo.org/index.php/reuma/article/view/reumatismo.2012.125
Calcium pyrophosphate dihydrate crystal deposition disease - WikipediaCalcium pyrophosphate dihydrate crystal deposition disease - Wikipedia
Calcium pyrophosphate dihydrate crystals are associated with a range of clinical syndromes, which have been given various names, based upon which clinical symptoms or radiographic findings are most prominent.[11] A task force of the European League Against Rheumatism (EULAR) made recommendations on preferred terminology.[5] Accordingly, calcium pyrophosphate deposition (CPPD) is an umbrella term for the various clinical subsets, whose naming reflects an emphasis on particular features. For example, pseudogout refers to the acute symptoms of joint inflammation or synovitis: red, tender, and swollen joints that may resemble gouty arthritis (a similar condition in which monosodium urate crystals are deposited within the joints). Chondrocalcinosis,[2][3] on the other hand, refers to the radiographic evidence of calcification in hyaline and/or fibrocartilage. Osteoarthritis (OA) with CPPD reflects a situation where osteoarthritis features are the most apparent. Pyrophosphate arthropathy refers to ...
https://en.wikipedia.org/wiki/Calcium_pyrophosphate_deposition_disease
RheumaKnowledgy » Calcium Pyrophoshate Dihydrate Crystal Deposition Disease (CPPD)RheumaKnowledgy » Calcium Pyrophoshate Dihydrate Crystal Deposition Disease (CPPD)
Synonyms: Pseudogout, chondrocalcinosis, pyrophosphate arthropathy.. ICD-9 Codes: Pseudogout, 712.2; CPPD crystal deposition disease, 712.2; chondrocalcinosis, 712.3.. Definition: CPPD crystal deposition disease includes arthritic syndromes associated with CPPD crystal deposition disease in articular tissues. The following definitions are used here:. -Chondrocalcinosis: Calcification of articular cartilage (identified by x-ray).. -Chronic CPPD crystal deposition disease: Structural bone and cartilage abnormalities associated with intraarticular deposition of CPPD crystals.. -Pseudogout: Clinical syndrome of acute synovitis caused by intraarticular CPPD crystal deposition, the most common form of CPPD crystal deposition disease.. Etiology: The cause of CPPD crystal deposition disease is unknown. Formation of CPPD crystals in cartilage may be related to matrix changes or result from elevated levels of calcium or inorganic pyrophosphate. Some cases appear to be hereditary, whereas others are ...
http://www.rheumaknowledgy.com/calcium-pyrophoshate-dihydrate-crystal-deposition-disease-cppd/
The association between ANKH promoter polymorphism and chondrocalcinosis is independent of age and osteoarthritis: results of a...The association between ANKH promoter polymorphism and chondrocalcinosis is independent of age and osteoarthritis: results of a...
Chondrocalcinosis (CC) most commonly results from calcium pyrophosphate crystal deposition (CPPD). The objective of this study is to examine the association between candidate single-nucleotide polymorphisms (SNPs) and radiographic CC. SNPs in ankylosis human (ANKH), high ferritin (HFE), tissue non-specific alkaline phosphatase (TNAP), ecto-neucleotide pyrophosphatase 1 (ENPP1), and transferrin (TE) genes were genotyped in participants of the Genetics of Osteoarthritis and Lifestyle (GOAL) and Nottingham Osteoarthritis Case-Control studies. Adjusted genotype odds ratio (aORGENOTYPE), the OR for association between one additional minor allele and CC, was calculated and adjusted for age, gender, body mass index (BMI), and osteoarthritis (OA) by using binary logistic regression. Statistical significance was set at P ≤0.003 after Bonferroni correction for multiple tests. The -4bpG | A polymorphism in the 5′ untranslated region (5′ UTR) of ANKH associated with CC after Bonferroni correction. This was
https://arthritis-research.biomedcentral.com/articles/10.1186/ar4453/tables/3
Pseudogout - The RheumatologistPseudogout - The Rheumatologist
Pseudogout is a type of arthritis that, as the name implies, can cause symptoms similar to gout, but which are a reaction to a different type of crystal deposit. This type of arthritis may be one of the most misunderstood forms, and is often mistaken for gout and other conditions, including RA. Proper diagnosis is important because untreated pseudogout may lead to a severe form of joint degeneration and ongoing inflammation, resulting in chronic disability.. Pseudogout develops when deposits of calcium pyrophosphate crystals accumulate in a joint. Initially, crystals deposit in the cartilage and can cause damage. They also can cause a reaction with inflammation that leads to joint pain and swelling. This can cause more chronic arthritis that mimics osteoarthritis or RA. Knees are most often involved, but wrists, shoulders, ankles, elbows, and hands can be affected. Ultimately, a patient with pseudogout could be incapacitated for days or weeks.. ...
https://www.the-rheumatologist.org/article/pseudogout/?singlepage=1&theme=print-friendly
Basic Calcium Phosphate Crystals Induce Osteoarthritis-Associated Changes in Chondrocyte Phenotype through Activation of...Basic Calcium Phosphate Crystals Induce Osteoarthritis-Associated Changes in Chondrocyte Phenotype through Activation of...
Basic Calcium Phosphate Crystals Induce Osteoarthritis-Associated Changes in Chondrocyte Phenotype through Activation of Calcium/Calmodulin Kinase ...
https://researchspace.auckland.ac.nz/handle/2292/46680
Crowned dens syndrome: a case report and review of the literature.
The crowned dens syndrome (CDS), also known as periodontoid calcium pyrophosphate dehydrate crystal deposition disease, is typified clinically by severe cervical pain, neck stiffness and atlantoaxial synovial calcification which could be misdiagnosed
http://www.biomedsearch.com/nih/Crowned-dens-syndrome-case-report/24891867.html
Global Sodium Citrate Dihydrate (CAS 6132-04-3) Market Size 2017 : Foodchem International, Cargill Incorporated, Citrique Belge...
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Pseudogout of the thoracic spine mimicking a tumor
Mohammad Sami Walid 1, Joshua C. Yelverton 2, Mohammed Ajjan 3, Arthur A. Grigorian 3. Medical Center of Central Georgia 1, Mercer University 2, Georgia Neurosurgical Institute 3, USA. Abstract. Objective & Importance: Crystal-induced arthritis (gout and pseudogout) usually affects peripheral joints whereas spine involvement with severe myelopathy is extremely rare. PubMed search yielded 42 results for gout myelopathy and 35 results for pseudogout myelopathy .. Clinical Presentation: We are reporting the case of a 62 years old female Caucasian who presented with severe thoracic myelopathy. MRI of the spine with contrast showed a 1.0´1.7 cm epidural soft tissue nodule with peripheral enhancement posterior to the thoracic cord at T9-10.. Intervention: Decompression and excision of the lesion was performed. Pathology revealed rhomboid-shaped, positively birefringent crystals. Uric acid was normal. The diagnosis of pseudogout was established.. Conclusion: Spinal crystal arthropathy should be ...
http://www.neuro.neva.ru/RNOnline_22/English/Issues/Articles_1_2008/mohammad.htm
Histopathological and ultrastructural studies of synovium in M...Histopathological and ultrastructural studies of synovium in M...
Histopathological and ultrastructural studies of synovium in Milwaukee shoulder syndrome--a basic calcium phosphate crystal arthropathy.: Light and electron mic
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Pseudogout Causes and Treatment - Brigham and Womens HospitalPseudogout Causes and Treatment - Brigham and Womens Hospital
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Thermal Behavior and Phase Transition of Uric Acid and Its Dihydrate Form, the Common Biominerals Uricite and Tinnunculite<...
TY - JOUR. T1 - Thermal Behavior and Phase Transition of Uric Acid and Its Dihydrate Form, the Common Biominerals Uricite and Tinnunculite. AU - Izatulina, Alina R.. AU - Gurzhiy, Vladislav V.. AU - Krzhizhanovskaya, Maria G.. AU - Chukanov, Nikita V.. AU - Panikorovskii, Taras L.. N1 - Izatulina, A.R.; Gurzhiy, V.V.; Krzhizhanovskaya, M.G.; Chukanov, N.V.; Panikorovskii, T.L. Thermal Behavior and Phase Transition of Uric Acid and Its Dihydrate Form, the Common Biominerals Uricite and Tinnunculite. Minerals 2019, 9, 373.. PY - 2019/6/22. Y1 - 2019/6/22. N2 - Single crystals and powder samples of uric acid and uric acid dihydrate, known as uricite and tinnunculite biominerals, were extracted from renal stones and studied using single-crystal and powder X-ray diffraction (SC and PXRD) at various temperatures, as well as IR spectroscopy. The results of high-temperature PXRD experiments revealed that the structure of uricite is stable up to 380 °C, and then it loses crystallinity. The crystal ...
https://pureportal.spbu.ru/ru/publications/thermal-behavior-and-phase-transition-of-uric-acid-and-its-dihydr
Potassium osmate(VI) dihydrate 10022-66-9 Precursor & Downstream Compound DictionaryPotassium osmate(VI) dihydrate 10022-66-9 Precursor & Downstream Compound Dictionary
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Citric acid, trisodium salt dihydrate, 99%, pure, ACROS Organicsâ„¢ | Fisher ScientificCitric acid, trisodium salt dihydrate, 99%, pure, ACROS Organicsâ„¢ | Fisher Scientific
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Quercetin Dihydrate - China - Manufacturer - Product CatalogQuercetin Dihydrate - China - Manufacturer - Product Catalog
GX017 GUXUAN China, Quercetin Dihydrate English name : Quercetin Dihydrate CAS No. 6151-25-3 Specification:98%UV Molecular Formula and Molecular Weight: C15H10O7.2H2O 338.27 Chemical Name: 4 H-
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Foscarnet calcium microcrystals as the intravitreal drug depot - Chemical Communications (RSC Publishing)Foscarnet calcium microcrystals as the intravitreal drug depot - Chemical Communications (RSC Publishing)
Foscarnet sodium is an antiviral drug for the treatment of CMV retinitis, currently in the form of twice-weekly intravitreal injection. Here we developed foscarnet calcium microcrystals as the drug depot, and using the rabbit model we demonstrated that the injected microcrystals maintained a therapeutically
http://pubs.rsc.org/en/content/articlelanding/2017/cc/c7cc02399e
Repositório Institucional da Universidade de Aveiro: Formation of self-assembled pattern of glycine microcrystals: experiment...Repositório Institucional da Universidade de Aveiro: Formation of self-assembled pattern of glycine microcrystals: experiment...
The films of glycine consisting of isolated microcrystals were prepared by spin coating and drying of the aqueous solution. Drying leads to dewetting (arising and growth of the holes) and formation of quasi-regular arrays of microcrystals that form the net structure consisting of Voronoi cells. The time dependence of the hole boundary velocity leading to formation of the straight net segments was proposed. Numerical model of hole nucleation and growth by boundary motion was proposed for the computer simulation. The coincidence of the simulated structures obtained within Kolmogorov alpha-model with experimental structures confirmed the validity of proposed approach ...
https://ria.ua.pt/handle/10773/20301
Pseudogout (Calcium Phyrophosphate Deposition Disease)Pseudogout (Calcium Phyrophosphate Deposition Disease)
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Calcium sulfate dihydrate | CaH4O6S - PubChemCalcium sulfate dihydrate | CaH4O6S - PubChem
Calcium sulfate dihydrate | CaH4O6S | CID 24928 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
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Analysis of Pure Calcium Chloride Dihydrate from China Manufacturer, Manufactory, Factory and Supplier on ECVV.comAnalysis of Pure Calcium Chloride Dihydrate from China Manufacturer, Manufactory, Factory and Supplier on ECVV.com
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Calcium sulfate dihydrate CAS 10101-41-4 | 102160Calcium sulfate dihydrate CAS 10101-41-4 | 102160
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Calcium Chloride Dihydrate Market Size study, by Product Type, By Application, and Regional Forecasts 2020-2026 - Decisive...Calcium Chloride Dihydrate Market Size study, by Product Type, By Application, and Regional Forecasts 2020-2026 - Decisive...
Calcium Chloride Dihydrate Market Size study, by Product Type, By Application, and Regional Forecasts 2020-2026, Share, Industry Trends and Competitive Landscape
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Epididymal injection of calcium chloride dihydrate s...Epididymal injection of calcium chloride dihydrate s...
Calcium chloride dihydrate in alcohol, lidocaine, or saline solution has been extensively studied for nonsurgical neuter for male animals. However, when...
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EMEA (Europe, Middle East and Africa) Trehalose Dihydrate Market Report 2017
Trehalose Dihydrate market report added by qyresearchgroups.com. In this Report includes best market price, trends, Growth, Forecast, Analysis, demand & Overview.
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Berberine chloride dihydrate M990031Berberine chloride dihydrate M990031
Citation: FINAL STUDY REPORT DEVELOPMENTAL TOXICITY RESEARCH EVALUATION OF BERBERINE CHLORIDE DIHYDRATE (CASRN 5956-60-5) ADMINISTERED BY GAVAGE TO SWISS (CD-1(r)) MICE ON GESTATIONAL DAYS 6 THROUGH 16 ...
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Sodium Molybdate Dihydrate BP n Pure Manufacturers, SDSSodium Molybdate Dihydrate BP n Pure Manufacturers, SDS
Sodium Molybdate Dihydrate BP Grade Manuacturers, SDS MSDS Sheet, Exporters to USA Canada Tanzania Egypt Turkey Mexico Argentina UAE
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Azithromycin Dihydrate Tablet Manufacturer,Supplier,Exporter
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Can I give my dog sodium citrate dihydrate? Will be going toCan I give my dog sodium citrate dihydrate? Will be going to
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Quercetin Dihydrate - Sunrise Botanics
Quercetin Dihydrate ships to Canada, USA and Worldwide. Buy botanical extracts and organic bulk herbs, spices and tea. Wholesale prices at Sunrise Botanics.
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Doc of Ages: September 2013Doc of Ages: September 2013
Of note in this discussion, however, is the immune systems response to the presence of calcium crystals in developing atherosclerotic lesions in arteries. Cells called macrophages which are first responders to bodily harm show up early in the course of blood vessel injury and set immediately to work eating foreign invaders Pac-Man style. As they gobble up various harmful substances such as oxidized LDL cholesterol or basic calcium phosphate (BCP) crystals, they send out proinflammatory cytokines which are chemical messenger molecules that further activate an immune response. This is a good thing with regards to incoming foreign bodies such as bacteria or dirt from the sidewalk when youve fallen and scraped your knee, but not so good when its an ongoing assault from various environmental insults such as LDL-cholesterol, trans-fats, cigarette smoke, or...too much calcium (more on this later). The inflammation from BCP crystals in activated macrophages may lead to a positive feed-back loop of ...
http://vintagefemail.blogspot.com/2013_09_01_archive.html
Particles 2001
Optimization for stoichiometric and morphology-controlled calcium phosphate crystals from bio-bearing calcium phosphate (BCP) under hydrothermal conditions ...
http://nanoparticles.org/Particles2001/PaperTitles.htm
Calcium Chloride, Dihydrate ≥99% [CAS# 10035-04-8] size: 500Calcium Chloride, Dihydrate ≥99% [CAS# 10035-04-8] size: 500
Calcium Chloride CAS product information; Calcium Chloride CAS is available 10 times from supplier caissonlab at Gentaur.com shop
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Concentrado Acido Para Hemodialisis 30-15 (Acetic Acid; Calcium Chloride Dihydrate; Glucose Anhydrous...) Reccius LaboratriosConcentrado Acido Para Hemodialisis 30-15 (Acetic Acid; Calcium Chloride Dihydrate; Glucose Anhydrous...) Reccius Laboratrios
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Calcium pyrophosphate arthritis: MedlinePlus Medical EncyclopediaCalcium pyrophosphate arthritis: MedlinePlus Medical Encyclopedia
Calcium pyrophosphate dihydrate (CPPD) arthritis is a joint disease that can cause attacks of arthritis. Like gout, crystals ... Terkeltaub R. Calcium crystal disease: calcium pyrophosphate dihydrate and basic calcium phosphate. In: Firestein GS, Budd RC, ... Calcium pyrophosphate dihydrate deposition disease; CPPD disease; Acute/chronic CPPD arthritis; Pseudogout; Pyrophosphate ... Deposition of calcium pyrophosphate dihydrate (CPPD) causes this form of arthritis. The buildup of this chemical forms crystals ...
https://medlineplus.gov/ency/article/000421.htm
Calcium Pyrophosphate Deposition (CPPD) Disease: Practice Essentials, Etiology, EpidemiologyCalcium Pyrophosphate Deposition (CPPD) Disease: Practice Essentials, Etiology, Epidemiology
... is a metabolic arthropathy caused by the deposition of calcium pyrophosphate dihydrate in and around joints, especially in ... Calcium pyrophosphate deposition (CPPD) disease is a metabolic arthropathy caused by the deposition of calcium pyrophosphate ... Calcium pyrophosphate deposition disease. Appearance of calcium pyrophosphate dihydrate crystals obtained from the knee of a ... encoded search term (Calcium Pyrophosphate Deposition (CPPD) Disease) and Calcium Pyrophosphate Deposition (CPPD) Disease What ...
https://www.medscape.com/answers/330936-103133/what-comorbidities-are-associated-with-calcium-pyrophosphate-deposition-disease-cpdd
Calcium Pyrophosphate Deposition (CPPD) Disease: Practice Essentials, Etiology, EpidemiologyCalcium Pyrophosphate Deposition (CPPD) Disease: Practice Essentials, Etiology, Epidemiology
... is a metabolic arthropathy caused by the deposition of calcium pyrophosphate dihydrate in and around joints, especially in ... Calcium pyrophosphate deposition (CPPD) disease is a metabolic arthropathy caused by the deposition of calcium pyrophosphate ... Calcium pyrophosphate deposition disease. Appearance of calcium pyrophosphate dihydrate crystals obtained from the knee of a ... encoded search term (Calcium Pyrophosphate Deposition (CPPD) Disease) and Calcium Pyrophosphate Deposition (CPPD) Disease What ...
http://emedicine.medscape.com/article/1268019-overview
Calcium pyrophosphate dihydrate crystal deposition disease and MRSA septic arthritis of the atlantoaxial joint in a patient...Calcium pyrophosphate dihydrate crystal deposition disease and MRSA septic arthritis of the atlantoaxial joint in a patient...
Calcium pyrophosphate dihydrate crystal deposition disease and MRSA septic arthritis of the atlantoaxial joint in a patient ... Calcium pyrophosphate dihydrate crystal deposition disease and MRSA septic arthritis of the atlantoaxial joint in a patient ... Fluid was aspirated from C1 to C2 joint by interventional radiology and showed calcium pyrophosphate crystals and heavy MRSA ...
https://casereports.bmj.com/content/12/3/e228102
Transmission electron microscopic identification of silicon-containing particles in synovial fluid: potential confusion with...Transmission electron microscopic identification of silicon-containing particles in synovial fluid: potential confusion with...
... potential confusion with calcium pyrophosphate dihydrate and apatite crystals. Message subject: (Your Name) has forwarded a ... potential confusion with calcium pyrophosphate dihydrate and apatite crystals. ... potential confusion with calcium pyrophosphate dihydrate and apatite crystals. ...
https://ard.bmj.com/content/43/4/624.share
From crystalline to amorphous calcium pyrophosphates:a solid state Nuclear Magnetic Resonance perspective - Lancaster EPrintsFrom crystalline to amorphous calcium pyrophosphates:a solid state Nuclear Magnetic Resonance perspective - Lancaster EPrints
Hydrated calcium pyrophosphates (CPP, Ca2P2O7·nH2O) are a fundamental family of materials among osteoarticular pathologic ... Statement of significance The general concept of NMR crystallography is applied to the detailed study of calcium pyrophosphates ... From crystalline to amorphous calcium pyrophosphates:a solid state Nuclear Magnetic Resonance perspective ... From crystalline to amorphous calcium pyrophosphates:a solid state Nuclear Magnetic Resonance perspective. Acta Biomaterialia, ...
https://eprints.lancs.ac.uk/id/eprint/78624/
Calcium Pyrophosphate Crystal Deposition Disease Treatment in DelhiCalcium Pyrophosphate Crystal Deposition Disease Treatment in Delhi
Looking for calcium pyrophosphate crystal deposition disease treatment in Delhi. Meet Dr Jatinder Juneja, one of the leading ... The movement of calcium pyrophosphate crystals in the joints can create sudden and severe pain in the joints. Inflammation can ... Calcium pyrophosphate crystal deposition disease, or CPPD, is a disorder that causes pain , redness, warmth, and swelling in ... The presence of small crystals of calcium pyrophosphate in the joints causes the body to react by means of inflammation to ...
https://www.drjatinderjuneja.com/cppd/
Rat-Bite Fever in Human with Streptobacillus notomytis Infection, Japan - Volume 24, Number 7-July 2018 - Emerging Infectious...
Circles indicate pyrophosphate calcium crystals. Arrows indicate chain-shaped gram-negative bacilli. Original magnification × ... Circles indicate pyrophosphate calcium crystals. Arrows indicate chain-shaped gram-negative bacilli. Original magnification × ... diagnosed by the presence of pyrophosphate calcium crystals). On day 20, we performed bilateral knee lavage; thereafter, the ... gram-negative bacilli with pyrophosphate calcium crystals and neutrophils (Figure). Bacterial culture yielded transparent, ...
https://wwwnc.cdc.gov/eid/article/24/7/17-1580
Organic: The Original Clean Food | Environmental Working GroupOrganic: The Original Clean Food | Environmental Working Group
For example, calcium acid pyrophosphate, a leavening agent for baked goods, was prohibited for use in organic food products ... Calcium acid pyrophosphate. Phosphoric acid used during manufacture of substance can cause toxicity to aquatic organisms if ...
https://www.ewg.org/research/packagedorganic
Photocaged Inositol pyrophosphates and their effects on Calcium - CIBSS Centre for Integrative Biological Signalling StudiesPhotocaged Inositol pyrophosphates and their effects on Calcium - CIBSS Centre for Integrative Biological Signalling Studies
We will study their impact on calcium oscillations within the imaginal disc of flies. The release of second messengers, such as ... The delivery and controlled release of small molecule second messengers with a focus on the inositol pyrophosphates into cells ... This project will enable the first delivery of inositol pyrophosphates within intact tissue by applying novel photocages and ... inositol pyrophosphates, with spatiotemporal resolution could potentially enable control of function in the development of ...
https://www.cibss.uni-freiburg.de/research/project/projects-details/jessen-c2
Melatonin as an Anti-Inflammatory Agent Modulating Inflammasome ActivationMelatonin as an Anti-Inflammatory Agent Modulating Inflammasome Activation
ASC: apoptotic-associated speck-like protein containing a caspase recruitment domain; CPPD: calcium pyrophosphate dihydrate; ...
https://www.hindawi.com/journals/ije/2017/1835195/
Identification of calcium pyrophosphate deposition disease (CPPD) by ultrasound: Reliability of the OMERACT definitions in an...Identification of calcium pyrophosphate deposition disease (CPPD) by ultrasound: Reliability of the OMERACT definitions in an...
Identification of calcium pyrophosphate deposition disease (CPPD) by ultrasound: Reliability of the OMERACT definitions in an ... Identification of calcium pyrophosphate deposition disease (CPPD) by ultrasound: Reliability of the OMERACT definitions in an ... Identification of calcium pyrophosphate deposition disease (CPPD) by ultrasound: Reliability of the OMERACT definitions in an ... Identification of calcium pyrophosphate deposition disease (CPPD) by ultrasound: Reliability of the OMERACT definitions in an ...
https://publires.unicatt.it/it/publications/identification-of-calcium-pyrophosphate-deposition-disease-cppd-b
Stain Control/Whitening Agents - Fundamentals of Dentifrice: Oral Health Benefits in a Tube - Dentalcare
Calcium carbonate. SMFP. Calcium pyrophosphate. SMFP, NaF, SnF2. Dicalcium phosphate dihydrate. SMFP. ... SHMP is also negatively charged, with a strong affinity for calcium. SHMP can displace stain molecules from calcium binding ... they have an affinity for positively charged ions like calcium (Ca2+) that reside in the tooth enamel and cross-link pellicle ...
https://www.dentalcare.com/en-us/ce-courses/ce410/stain-control-whitening-agents
List articles by category - Best Practice New ZealandList articles by category - Best Practice New Zealand
Calcium pyrophosphate deposition disease: The arthropathy formerly known as "Pseudogout". A number of clinical syndromes are ... associated with the precipitation of calcium pyrophosphate dihydrate crystals in and around... View Article ... Osteoporosis and subsequent fracture may be prevented by maintaining adequate calcium and vitamin D levels, undertaking regular ...
https://bpac.org.nz/ListByCategory.aspx?CategoryId=38
Pseudogout: Causes, Symptoms and TreatmentPseudogout: Causes, Symptoms and Treatment
They are sometimes mentioned as calcium pyrophosphate deposition disease. Very harsh incidents of confined pain and swelling ... Any kind of affront to the joint can activate the discharge of the calcium crystals provoking excruciating swelling rejoinder. ...
http://www.home-remedies-for-you.com/articles/363/diseases-and-ailments/pseudogout.html
CME/CE QuizCME/CE Quiz
d) identification of calcium pyrophosphate dihydrate crystals. 12. Dietary restrictions with weight loss and decreased ...
https://www.ajmc.com/view/nov05-2220ps465-s468
Medical Dictionary of Health Terms: J-P - Harvard HealthMedical Dictionary of Health Terms: J-P - Harvard Health
pseudogout: Arthritis caused by crystals of calcium pyrophosphate dihydrate in the joints. Also known as calcium pyrophosphate ... N-methyl-D-aspartame receptor: A molecule on the surface of a brain cell that admits calcium when activated by the chemical ... parathyroid hormone: A hormone that controls levels of calcium and phosphorous in the blood and influences bone loss and growth ... parathyroid glands: Glands responsible for releasing a hormone that controls calcium levels and influences bone loss and growth ...
https://www.health.harvard.edu/j-through-p
Dr Ryan Pink - Oxford Brookes UniversityDr Ryan Pink - Oxford Brookes University
ANKH mutations are associated with calcium pyrophosphate deposition disease and craniometaphyseal dysplasia. This study ... We generated four ANKH overexpression-plasmids containing either calcium pyrophosphate deposition disease or craniometaphyseal ... Differences in intracellular localisation of ANKH mutants that relate to mechanisms of calcium pyrophosphate deposition disease ... Extracellular inorganic pyrophosphate, mineralization, ENPP1 activity expression of ENPP1, TNAP and PIT-1 were measured. P5L ...
https://www.brookes.ac.uk/profiles/staff/ryan-pink
Hyperparathyroidism | Multimedia Encyclopedia | Health Information | St. Lukes HospitalHyperparathyroidism | Multimedia Encyclopedia | Health Information | St. Luke's Hospital
Calcium blood test Calcium blood test. The calcium blood test measures the level of calcium in the blood. This article ... When calcium level is too low, the body responds by making more PTH. This causes the calcium level in the blood to rise. ... Symptoms are mostly caused by damage to organs from high calcium level in the blood, or by the loss of calcium from the bones. ... Calcium pyrophosphate arthritis (Condition) * Urinary tract infection (In-Depth) * Kidney stones (In-Depth) ...
https://www.stlukes-stl.com/health-content/health-ency-multimedia/1/001215.htm
Thieme E-Journals - Radiologie up2date / AbstractThieme E-Journals - Radiologie up2date / Abstract
13 Resnick D, Niwayama G, Goergen T G. et al . Clinical, radiographic and pathologic abnormalities in calcium pyrophosphate ... 8 Dieppe P A, Alexander G JH, Jones H E. et al . Pyrophosphate arthropathy: a clinical and radiological study of 105 cases. Ann ...
https://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-0030-1255595?id=&lang=de
Joints Information - myVMCJoints Information - myVMC
Rheumatology information from specialist doctors in arthritis treatment and other arthritic rheumatic diseases; online information about rheumatoid arthritis medical science in the field of rheumatology
https://www.myvmc.com/joints-centre/page/40/
Meniscal Tears on MRI: Practice Essentials, Anatomy, Descriptions and ClassificationsMeniscal Tears on MRI: Practice Essentials, Anatomy, Descriptions and Classifications
... calcium hydroxyapatite, or any combination of these substances (see the image below). Calcium pyrophosphate dihydrate crystal ... Calcification of the menisci and/or articular cartilage due to the deposition of calcium pyrophosphate dihydrate crystal, ... This finding represents calcium in the triangular menisci, which represents chondrocalcinosis. A globular calcium opacity ( ... This finding represents calcium in the triangular menisci, which represents chondrocalcinosis. A globular calcium opacity ( ...
https://emedicine.medscape.com/article/399552-overview
All About Pseudogout - Symptoms, Diagnosis, Treatment | Arthritis-healthAll About Pseudogout - Symptoms, Diagnosis, Treatment | Arthritis-health
Pseudogout is a type of arthritis known as calcium pyrophosphate deposition (CPPD) or acute CPP crystal arthritis. Learn how ... What Is Calcium Pyrophosphate Deposition (CPPD) Disease?. Pseudogout is just one form of calcium pyrophosphate deposition (CPPD ... Pseudogout is caused by calcium pyrophosphate dihydrate crystals, often referred to as calcium pyrophosphate crystals or CPP ... Doctors may refer to pseudogout as calcium pyrophosphate deposition (CPPD) or acute calcium pyrophosphate crystal arthritis ( ...
https://www.arthritis-health.com/types/pseudogout-cppd/all-about-pseudogout-symptoms-diagnosis-treatment
JCI - Volume 56, Issue 6JCI - Volume 56, Issue 6
The distribution of calcium pyrophosphate mineral phase, almost exclusively confined to articular cartilage in ... altered ionized calcium level. Diffusible calcium in synovial fluid was only 40% of the total calcium concentration, which ... The solubility of triclinic calcium pyrophosphate dihydrate (CPPD) crystals was measured under varying conditions using 45Ca- ... In the same group of dogs, administration of sodium bicarbonate plus calcium prevented the fall in ionized calcium, and ...
https://www.jci.org/56/6
eHealth - Prince Court Medical CentreeHealth - Prince Court Medical Centre
Calcium Pyrophosphate Deposition (CPPD). Carpal Tunnel Syndrome. Dermatomyositis. Fibromyalgia. Giant Cell Arteritis. ... Diabetes Mellitus, Thyroid & Parathyroid Disorders, Adrenal Disorders, Osteoporosis & Calcium Metabolism, Pituitary Disorders, ...
https://princecourt.com/ehealth/
Crystal-Induced Arthritis After Total Ankle Arthroplasty in: Journal of the American Podiatric Medical Association Volume 109...Crystal-Induced Arthritis After Total Ankle Arthroplasty in: Journal of the American Podiatric Medical Association Volume 109...
Hirose CB, Wright RW: Calcium pyrophosphate dihydrate deposition disease (pseudogout) after total knee arthroplasty. J ... Calcium pyrophosphate dihydrate deposition disease (pseudogout) after total knee arthroplasty. . J Arthroplasty. 22. : 273. , ...
https://japmaonline.org/abstract/journals/apms/109/2/17-097.xml?rskey=Y8QO2A&result=4
Publications | OHSUPublications | OHSU
Photolysis of cell-permeant caged inositol pyrophosphates controls oscillations of cytosolic calcium in a β-cell line. Chem Sci ... Regulation of Calcium Oscillations in β-Cells by Co-activated Cannabinoid Receptors. Cell Chem Biol. 2020 Nov 2:S2451-9456(20) ... Laguerre, A., Keutler, K., Hauke, S., Schultz, C. Regulation of calcium oscillations in ß-cells by co-activated cannabinoid ... Age-related changes in cardiac electrophysiology and calcium handling in response to sympathetic nerve stimulation. J Physiol. ...
https://www.ohsu.edu/school-of-medicine/chemical-physiology-and-biochemistry/publications
phosphocitrate | Semantic Scholarphosphocitrate | Semantic Scholar
Calcium deposition diseases caused by calcium pyrophosphate dihydrate (CPPD) and basic calcium phosphate (BCP) crystals are a… ... Induction of Matrix Metalloproteinase-8 in Human Fibroblasts by Basic Calcium Phosphate and Calcium Pyrophosphate Dihydrate ... Phosphocitrate Inhibits a Basic Calcium Phosphate and Calcium Pyrophosphate Dihydrate Crystal-induced Mitogen-activated Protein ... Inhibition of Calcium Pyrophosphate Dihydrate Crystal Formation in Articular Cartilage Vesicles and Cartilage by Phosphocitrate ...
https://www.semanticscholar.org/topic/phosphocitrate/855
PseudogoutCPPDInorganic pyrophosphatePhosphateArthritisArthropathyGoutDeposition diseasesDiseaseJointsDisodiumCitrateCrystalPhosphorusIonsDepositsMicroscopicBisphosphonatesHydroxyapatiteTissuesAluminumSymptomsInflammationAffectsDepositionCrystalsCarbonateSaltOsteoarthritisProteinLactateThiamine pyrophosphateNiacinCalcificationDextroseCitrateMagnesium
Pseudogout15
  • Fluid was aspirated from C1 to C2 joint by interventional radiology and showed calcium pyrophosphate crystals and heavy MRSA colonisation, consistent with both pseudogout and septic arthritis of the cervical vertebrae. (bmj.com)
  • We replaced ceftriaxone with sulbactam and ampicillin on hospital day 16, followed by intraarticular administration of dexamethasone on day 17 for pseudogout (diagnosed by the presence of pyrophosphate calcium crystals). (cdc.gov)
  • Pseudogout occurs when microscopic calcium pyrophosphate crystals accumulate in a joint and trigger an immune system response. (arthritis-health.com)
  • Doctors may refer to pseudogout as calcium pyrophosphate deposition (CPPD) or acute calcium pyrophosphate crystal arthritis (acute CPP crystal arthritis). (arthritis-health.com)
  • Pseudogout is caused by calcium pyrophosphate dihydrate crystals, often referred to as calcium pyrophosphate crystals or CPP crystals. (arthritis-health.com)
  • Researchers have known about calcium pyrophosphate crystals for decades but still do not fully understand why some people who have them experience pseudogout episodes and others do not. (arthritis-health.com)
  • Pseudogout is just one form of calcium pyrophosphate deposition (CPPD) disease. (arthritis-health.com)
  • Pseudogout is a type of arthritis in which crystals of calcium phosphate or other chemicals are deposited in the joints. (caringmedical.com)
  • Pseudogout results from the formation of calcium phosphate crystals in the cartilage, which is followed by the release of crystals into the joint fluid. (caringmedical.com)
  • Modern medical doctors may also use x-ray technology as a diagnostic tool to locate the calcium containing crystals associated with pseudogout. (caringmedical.com)
  • There is also something called pseudogout, which is caused by calcium pyrophosphate crystals. (meltmethod.com)
  • A knee joint aspirate revealed calcium pyrophosphate crystals diagnostic of acute pseudogout ( Figure 2 ). (consultant360.com)
  • The patient's clinical and radiographic findings, as well as knee joint aspirate, were consistent with the diagnosis of pseudogout, or calcium pyrophosphate crystal deposition disease (CPPD), of the cervicooccipital junction-also known as the crowned dens syndrome. (consultant360.com)
  • Pseudogout is a disease of calcium pyrophosphate crystal deposition in tissues. (topgradeapp.com)
  • In this case scenario, based on the patient's history and laboratory findings, it would be appropriate to include arthrocentesis and synovial fluid analysis in the initial workup for RA to rule out gout, pseudogout (calcium pyrophosphate deposition disease [CPPD]) , and septic arthritis . (medscape.com)
CPPD8
  • Calcium pyrophosphate dihydrate (CPPD) arthritis is a joint disease that can cause attacks of arthritis. (medlineplus.gov)
  • Deposition of calcium pyrophosphate dihydrate (CPPD) causes this form of arthritis . (medlineplus.gov)
  • Calcium pyrophosphate deposition (CPPD) disease is a metabolic arthropathy caused by the deposition of calcium pyrophosphate dihydrate in and around joints, especially in articular cartilage and fibrocartilage (see the images below). (medscape.com)
  • Although the exact mechanism for the development of CPPD remains unknown, increased adenosine triphosphate breakdown with resultant increased inorganic pyrophosphate in the joints results from aging, genetic factors, or both. (medscape.com)
  • Therefore, inorganic pyrophosphate can bind calcium, leading to CPPD deposition in the cartilage and synovium. (medscape.com)
  • Calcium pyrophosphate crystal deposition disease, or CPPD, is a disorder that causes pain , redness, warmth, and swelling in one or more joints. (drjatinderjuneja.com)
  • Objectives: To assess the reliability of the OMERACT ultrasound (US) definitions for the identification of calcium pyrophosphate deposition disease (CPPD) at the metacarpal-phalangeal, triangular fibrocartilage of the wrist (TFC), acromioclavicular (AC) and hip joints. (unicatt.it)
  • A person who has calcium pyrophosphate crystals (CPP crystals) in one or more joints is considered to have CPPD disease. (arthritis-health.com)
Inorganic pyrophosphate3
  • The ANKH protein is involved in transport of inorganic pyrophosphate (PPi), which regulates calcification, bone mineralization, and bone resorption. (medscape.com)
  • An inorganic pyrophosphate which affects calcium metabolism in mammals. (bvsalud.org)
  • Association of sporadic chondrocalcinosis with a -4-basepair G-to-A transition in the 5'-untranslated region of ANKH that promotes enhanced expression of ANKH protein and excess generation of extracellular inorganic pyrophosphate. (cdc.gov)
Phosphate7
  • Terkeltaub R. Calcium crystal disease: calcium pyrophosphate dihydrate and basic calcium phosphate. (medlineplus.gov)
  • Medical conditions that cause low blood calcium or increased phosphate can also lead to hyperparathyroidism. (stlukes-stl.com)
  • Phosphate-dependent stimulation of MGP and OPN expression in osteoblasts via the ERK1/2 pathway is modulated by calcium. (semanticscholar.org)
  • Global food phosphate market from calcium phosphate application is set to register a CAGR of over 6% through 2027 as it acts as acidity regulator in baking powder and is used as bread enhancer. (gminsights.com)
  • Whereas 52% of these patients may have stones composed entirely of uric acid, 20% may develop calcium oxalate or sometimes calcium phosphate stones. (medscape.com)
  • In the present study, we show that, in pituitary GH 4 C 1 cells, C1P (C 2 - ceramide 1 - phosphate ) enhances calcium entry in a dose-dependent manner. (silverchair.com)
  • Increases in the dephosphorylation of lysophosphatidate, ceramide 1 - phosphate , sphingosine 1-phosphate and diacylglycerol pyrophosphate were similar to those for phosphatidate. (silverchair.com)
Arthritis5
  • Filippucci is rated as an Elite expert by MediFind in the treatment of Calcium Pyrophosphate Arthritis. (medifind.com)
  • His top areas of expertise are Calcium Pyrophosphate Arthritis, Chondrocalcinosis 2, Arthritis, and Gout. (medifind.com)
  • Tedeschi has been practicing medicine for over 12 years and is rated as an Elite expert by MediFind in the treatment of Calcium Pyrophosphate Arthritis. (medifind.com)
  • Her top areas of expertise are Calcium Pyrophosphate Arthritis, Arthritis, Systemic Lupus Erythematosus (SLE), and Temporal Arteritis. (medifind.com)
  • Her top areas of expertise are Calcium Pyrophosphate Arthritis, Synovitis, Arthritis, and Rheumatoid Arthritis (RA). (medifind.com)
Arthropathy1
  • Pyrophosphate arthropathy: a clinical and radiological study of 105 cases. (thieme-connect.de)
Gout1
  • His actual diagnosis was "eleven different types of gout and a severe, gout-like case of calcium pyrophosphate deposition disease. (wondermark.com)
Deposition diseases1
  • Forty-seven patients were included (17 gouts, 11 calcium pyrophosphate deposition diseases, 13 rheumatoid arthritides, 6 spondyloarthritides). (greenmedinfo.com)
Disease2
  • They are sometimes mentioned as calcium pyrophosphate deposition disease. (home-remedies-for-you.com)
  • In fact, one clinical study 3 Viriyavejkul P, Wilairatana V, Tanavalee A, Jaovisidha K. Comparison of characteristics of patients with and without calcium pyrophosphate dihydrate crystal deposition disease who underwent total knee replacement surgery for osteoarthritis. (arthritis-health.com)
Joints5
  • Instead, x-rays of affected joints such as knees show characteristic deposits of calcium. (medlineplus.gov)
  • The presence of small crystals of calcium pyrophosphate in the joints causes the body to react by means of inflammation to attack them. (drjatinderjuneja.com)
  • The movement of calcium pyrophosphate crystals in the joints can create sudden and severe pain in the joints. (drjatinderjuneja.com)
  • OBJECTIVE Calcium deposition occurs frequently in osteoarthritic (OA) joints. (semanticscholar.org)
  • The calcium deposits and inflammation can cause parts of the joints to weaken and break down. (caringmedical.com)
Disodium1
  • α-Canaphite (CaNa 2 P 2 O 7 ·4H 2 O) is a layered calcium disodium pyrophosphate tetrahydrate phase of significant geological and potential biological interest. (cea.fr)
Citrate1
  • DB are visualized in unfixed, unstained, whole mount EM preparations due to their calcium content or by staining platelets with lead citrate and uranyl acetate. (medscape.com)
Crystal2
  • Calcium pyrophosphate dehydrate crystal deposition in the craniovertebral junction. (consultant360.com)
  • Calcium pyrophosphate crystal deposition in a cohort of 57 patients with Gitelman syndrome. (cdc.gov)
Phosphorus1
  • PTH helps control calcium, phosphorus, and vitamin D levels in the blood and bone. (stlukes-stl.com)
Ions2
  • they have an affinity for positively charged ions like calcium (Ca 2+ ) that reside in the tooth enamel and cross-link pellicle proteins. (dentalcare.com)
  • This peculiar water molecule could be the last to leave the collapsed structure on heating, leading eventually to anhydrous α-CaNa 2 P 2 O 7 and could also be involved in the internal hydrolysis of pyrophosphate ions as it is the closest water molecule to the pyrophosphate ions. (cea.fr)
Deposits2
  • The EDPC is generated by deposits of calcium pyrophosphate crystals in a joint. (drjatinderjuneja.com)
  • X-rays, ultrasound, or CT scans of the kidneys or urinary tract may show calcium deposits or a blockage. (stlukes-stl.com)
Microscopic2
  • Transmission electron microscopic identification of silicon-containing particles in synovial fluid: potential confusion with calcium pyrophosphate dihydrate and apatite crystals. (bmj.com)
  • Q.78 Anomocytic stomata, trichomes with collapsed cell and absence of calcium oxalate crystals are some of the microscopic features of which plant? (pharmatutor.org)
Bisphosphonates1
  • Bisphosphonates are synthetic analogs of pyrophosphate that bind to the hydroxyapatite found in bone. (rxdrugnews.com)
Hydroxyapatite1
  • Microcalcifications containing calcium hydroxyapatite (HA) are often associated with malignant human breast lesions. (semanticscholar.org)
Tissues1
  • The delivery and controlled release of small molecule second messengers with a focus on the inositol pyrophosphates into cells and tissues is the goal of this project. (uni-freiburg.de)
Aluminum1
  • Studies in monkeys showed concurrent use with calcium, aluminum, or iron caused significantly decreased plasma levels. (medscape.com)
Symptoms2
  • Symptoms are mostly caused by damage to organs from high calcium level in the blood, or by the loss of calcium from the bones. (stlukes-stl.com)
  • If you have a mildly increased calcium level and don't have symptoms, you may choose to have regular checkups or get treated. (stlukes-stl.com)
Inflammation1
  • Pathologic examination showed calcium pyrophosphate depositions without signs of inflammation. (bvsalud.org)
Affects1
  • This study aimed at assessing how urine dilution affects urinary calcium oxalate crystallization. (degruyter.com)
Deposition35
  • Gitelman syndrome can mimic several other manifestations of calcium pyrophosphate deposition (CPPD) disease , including osteoarthritis, carpal tunnel syndrome, and tenosynovitis with calcifications along the tendon sheath itself. (medscape.com)
  • Basic calcium phosphate deposition disease and Lyme arthritis are also included in the differential diagnosis of CPPD. (medscape.com)
  • Zamora EA, Naik R. Calcium Pyrophosphate Deposition Disease (Pseudogout). (medscape.com)
  • Calcium pyrophosphate dihydrate crystal deposition disease--1975. (medscape.com)
  • Beutler A, Rothfuss S, Clayburne G. Calcium pyrophosphate dihydrate crystal deposition in synovium. (medscape.com)
  • Genetics and Mechanisms of Crystal Deposition in Calcium Pyrophosphate Deposition Disease. (medscape.com)
  • Calcium pyrophosphate crystal deposition in hyaline cartilage. (medscape.com)
  • Elevated levels in some patients with calcium pyrophosphate dihydrate deposition disease. (medscape.com)
  • Doherty M, Hamilton E, Henderson J. Familial chondrocalcinosis due to calcium pyrophosphate dihydrate crystal deposition in English families. (medscape.com)
  • The prevalence of chondrocalcinosis of the symphysis pubis on CT scan and correlation with calcium pyrophosphate dihydrate crystal deposition disease. (medscape.com)
  • Kleiber Balderrama C, Rosenthal AK, Lans D, Singh JA, Bartels CM. Calcium Pyrophosphate Deposition Disease and Associated Medical Comorbidities: A National Cross-Sectional Study of US Veterans. (medscape.com)
  • Paalanen K, Rannio K, Rannio T, Asikainen J, Hannonen P, Sokka T. Prevalence of calcium pyrophosphate deposition disease in a cohort of patients diagnosed with seronegative rheumatoid arthritis. (medscape.com)
  • Calcium pyrophosphate deposition (CPPD) disease is a metabolic arthropathy caused by the deposition of calcium pyrophosphate dihydrate in and around joints, especially in articular cartilage and fibrocartilage (see the images below). (medscape.com)
  • Therefore, inorganic pyrophosphate can bind calcium, leading to CPPD deposition in the cartilage and synovium. (medscape.com)
  • Deposition of calcium pyrophosphate dihydrate (CPPD) causes this form of arthritis . (medlineplus.gov)
  • Calcium pyrophosphate deposition disease (CPPD) is a type of arthritis. (verywellhealth.com)
  • Calcium pyrophosphate crystal deposition is confined to hyaline cartilage, fibrocartilage, and areas of chondroid metaplasia (ie, degenerated areas of tendons, ligaments, and the joint capsule) within the joint. (medscape.com)
  • Tophaceous calcium pyrophosphate dihydrate deposition disease of the temporomandibular joint. (nih.gov)
  • Pseudogout has sometimes been referred to as calcium pyrophosphate deposition disease or CPPD. (rxlist.com)
  • 13. Proton-Pump Inhibitors and Risk of Calcium Pyrophosphate Deposition in a Population-Based Study. (nih.gov)
  • Medical term for this inflammation s Calcium Pyrophosphate Deposition Disease or CPDD but the term pseudogout was coined due to condition's striking similarity to gout. (jointhealthmagazine.com)
  • European League Against Rheumatism recommendations for calcium pyrophosphate deposition. (unige.ch)
  • Ultrasound is a reliable diagnostic tool for identifying calcium pyrophosphate deposition disease. (rheumatologyadvisor.com)
  • Non-urate calcium-containing crystal deposition diseases that affect the joints and surrounding structures include calcium pyrophosphate dihydrate (CPPD) crystal deposition disease and hydroxyapatite crystal deposition disease (also known as basic calcium phosphate crystallopathy). (nih.gov)
  • Rheumatoid arthritis, crystal deposition diseases (including gouty arthropathy and calcium pyro-phosphate deposition disease), seronegative spondyloarthropathies (including psoriatic arthritis, reactive arthritis, ankylosing spondylitis), and osteoarthritis have characteristic appearances on MRI. (polradiol.com)
  • This article describes the MRI findings of normal joints, as well as the pathophysiological mechanisms and typical MRI findings of rheumatoid arthritis, gouty arthritis, calcium pyrophosphate deposition disease, psoriatic arthritis, reactive arthritis, ankylosing spondylitis, and osteoarthritis. (polradiol.com)
  • Discuss the clinical presentation, causes, relevant diagnostic tests, and management of Calcium Pyrophosphate Dihydrate (CPPD) Deposition Disease. (nih.gov)
  • Discuss the clinical presentation, causes, relevant diagnostic tests, and management of Basic Calcium Phosphate (BCP) Deposition Disease. (nih.gov)
  • Calcium pyrophosphate deposition (CPPD) is due to calcium crystals depositing within joints. (omeract.org)
  • There are a number of forms reported: an anhydrous form, a dihydrate, Ca 2 P 2 O 7 ·2H 2 O and a tetrahydrate, Ca 2 P 2 O 7 ·4H 2 O. Deposition of dihydrate crystals in cartilage are responsible for the severe joint pain in cases of calcium pyrophosphate deposition disease (pseudo gout) whose symptoms are similar to those of gout. (toothpastetop.com)
  • The deposition of basic calcium phosphate and calcium pyrophosphate dihydrate crystals in articular tissues is probably an under-recognized event. (elsevier.com)
  • When calcium pyrophosphate forms, calcium deposition takes place, and pseudogout results. (rahulgladwin.com)
  • Calcium pyrophosphate crystal deposition disease, pseudogout, and articular chondrocalcinosis. (epo.org)
  • Definitely, you'll see gout and pseudogout (calcium pyrophosphate deposition, or CPPD). (medscape.com)
  • Gout and pseudogout are the 2 most common crystalline arthropathies and are caused by deposition of monosodium urate (MSU) and calcium pyrophosphate dihydrate (CPPD) crystals, respectively. (medscape.com)
Crystals24
  • It is caused by deposits of calcium phosphate crystals in the joints and has similar characteristics to gout . (verywellhealth.com)
  • According to statistics from the American College of Rheumatology, the development of calcium crystals occurs in almost 3% of adults in their 50s. (verywellhealth.com)
  • The responsible crystals include monosodium urate, calcium pyrophosphate dihydrate, basic calcium phosphate (including hydroxyapatite), and calcium oxalate. (medscape.com)
  • Circles indicate pyrophosphate calcium crystals. (cdc.gov)
  • Gram stain demonstrated the presence of few, thin, gram-negative bacilli with pyrophosphate calcium crystals and neutrophils ( Figure ). (cdc.gov)
  • We replaced ceftriaxone with sulbactam and ampicillin on hospital day 16, followed by intraarticular administration of dexamethasone on day 17 for pseudogout (diagnosed by the presence of pyrophosphate calcium crystals). (cdc.gov)
  • A number of clinical syndromes are associated with the precipitation of calcium pyrophosphate dihydrate crystals in and around. (bpac.org.nz)
  • Pseudogout is a type of inflammation of joints (arthritis) that is caused by deposits of crystals, called calcium pyrophosphate, in and around the joints. (rxlist.com)
  • Pseudogout is primarily caused by the precipitation of calcium pyrophosphate dihydrate crystals developing within a joint space. (rxlist.com)
  • With this microscope, the calcium pyrophosphate crystals are clearly identified by their characteristic shape and color (medically term weakly positively birefringent rhomboid crystals). (rxlist.com)
  • Pseudogout is caused by precipitation of calcium pyrophosphate dihydrate crystals and affects mainly the knees and wrists, but can occur in the first metatarsophalangeal and other joints as well. (bpac.org.nz)
  • Rarely, calcium oxalate, apatite and lipid crystals may be found. (bpac.org.nz)
  • An abnormal formation of calcium pyrophosphate (CPP) crystals in the joint and surrounding tissues causes pseudogout. (medicinenet.com)
  • Neither monosodium urate crystals nor calcium pyrophosphate crystals were found. (medworm.com)
  • There can be different crystals - CPPD (calcium pyrophosphate) or urate, calcium etc. that can accumulate. (ndtv.com)
  • Pseudo gout is quite similar to gout, except the attacks are usually less severe and the crystals are composed of calcium pyrophosphate dihydrate. (family-health-information.com)
  • Calcium pyrophosphate dihydrate crystals occurs. (getfreshsd.com)
  • Not all people with calcium crystals in their joints experience symptoms. (omeract.org)
  • Instead, pseudogout is caused as a result of calcium pyrophosphate crystals, which cause a gout like reaction. (liftchairguide.net)
  • With pseudogout, however, the crystals are formed from a salt called calcium pyrophosphate dihydrate. (arthritisfoundationasia.com)
  • She described a key role of the pyrophosphate pathway, which is involved in the production of basic calcium phosphate (BCP) crystals. (the-rheumatologist.org)
  • pseudogout is caused by calcium pyrophosphate crystals and is more accurately termed calcium pyrophosphate disease. (medscape.com)
  • Calcium pyrophosphate dihydrate (CPPD) crystals are shorter and less sharp than MSU crystals. (medscape.com)
  • Theiler G, Quehenberger F, Rainer F, Neubauer M, Stettin M, Robier C. The detection of calcium pyrophosphate crystals in the synovial fluid of patients with rheumatoid arthritis using the cytospin technique: prevalence and clinical correlation. (medscape.com)
Carbonate1
  • Characterization results confirmed the presence of calcium carbonate crystallites along with the amorphous silica matrix. (degruyter.com)
Salt2
  • Search results for Ionomycin calcium salt at Sigma-Aldrich Changes will be taking place on SigmaAldrich on June 5, 2021 that include visual and functional updates. (jefvanesch.be)
  • It is a chemical compound, an insoluble calcium salt containing the pyrophosphate anion. (toothpastetop.com)
Osteoarthritis1
  • The prevalence and incidence of calcium crystal arthropathies are expected to increase as a result of the growing elderly population in the U.S. and increasing numbers of people with osteoarthritis predisposing cartilage to calcification disorders. (nih.gov)
Protein1
  • Although this protein was initially thought to be the mitochondrial deoxynucleotide carrier involved in the uptake of deoxynucleotides into the matrix of the mitochondria, further studies have demonstrated that this protein instead functions as the mitochondrial thiamine pyrophosphate carrier, which transports thiamine pyrophosphates into mitochondria. (nih.gov)
Lactate1
  • The National Formulary uses lactate of calcium, phosphoric acid, and elixir of cinchona and iron. (chestofbooks.com)
Thiamine pyrophosphate1
  • Mitochondrial transporter mediating uptake of thiamine pyrophosphate (ThPP) into mitochondria. (nih.gov)
Niacin1
  • Portable, chewy and sweetly flavorful, each bar is a good source of calcium and iron and an excellent source of vitamin A, thiamin, niacin and vitamin B6. (picknsave.com)
Calcification1
  • Pyrophosphate, phosphonates and pyrophosphatases in the regulation of calcification and calcium homeostasis. (ox.ac.uk)
Dextrose1
  • SKIN ON POTATO CHUNKS - [POTATO CHUNKS, SKIN ON -Potatoes, vegetable oil (soybean, canola, and/or cottonseed oils), contains less than 2% of dextrose, disodium dihydrogen pyrophosphate (to maintain natural color). (magickitchen.com)
Citrate2
  • 84. Elixir Of Calisaya Bark With Pyrophosphate Of Iron, Citrate Of Ammonium And Bismuth, And Strychnine. (chestofbooks.com)
  • DB are visualized in unfixed, unstained, whole mount EM preparations due to their calcium content or by staining platelets with lead citrate and uranyl acetate. (medscape.com)
Magnesium1
  • Mineral imbalances - People with excessive amounts of iron and calcium or insufficient amount of magnesium in their blood have higher chances of getting this condition. (jointhealthmagazine.com)
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