An inorganic pyrophosphate which affects calcium metabolism in mammals. Abnormalities in its metabolism occur in some human diseases, notably HYPOPHOSPHATASIA and pseudogout (CHONDROCALCINOSIS).
Presence of calcium salts, especially calcium pyrophosphate, in the cartilaginous structures of one or more joints. When accompanied by attacks of goutlike symptoms, it is called pseudogout. (Dorland, 27th ed)
Inorganic salts of phosphoric acid that contain two phosphate groups.
Microscopy using polarized light in which phenomena due to the preferential orientation of optical properties with respect to the vibration plane of the polarized light are made visible and correlated parameters are made measurable.
The formation of crystalline substances from solutions or melts. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
General disorders of the sclera or white of the eye. They may include anatomic, embryologic, degenerative, or pigmentation defects.
Calcium salts of phosphoric acid. These compounds are frequently used as calcium supplements.
The clear, viscous fluid secreted by the SYNOVIAL MEMBRANE. It contains mucin, albumin, fat, and mineral salts and serves to lubricate joints.
Membrane proteins that are involved in the active transport of phosphate.
Hereditary metabolic disorder characterized by recurrent acute arthritis, hyperuricemia and deposition of sodium urate in and around the joints, sometimes with formation of uric acid calculi.
A group of enzymes within the class EC 3.6.1.- that catalyze the hydrolysis of diphosphate bonds, chiefly in nucleoside di- and triphosphates. They may liberate either a mono- or diphosphate. EC 3.6.1.-.
An oxidation product, via XANTHINE OXIDASE, of oxypurines such as XANTHINE and HYPOXANTHINE. It is the final oxidation product of purine catabolism in humans and primates, whereas in most other mammals URATE OXIDASE further oxidizes it to ALLANTOIN.
Pathologic deposition of calcium salts in tissues.
A progressive, degenerative joint disease, the most common form of arthritis, especially in older persons. The disease is thought to result not from the aging process but from biochemical changes and biomechanical stresses affecting articular cartilage. In the foreign literature it is often called osteoarthrosis deformans.
The mineral component of bones and teeth; it has been used therapeutically as a prosthetic aid and in the prevention and treatment of osteoporosis.
A synovial hinge connection formed between the bones of the FEMUR; TIBIA; and PATELLA.
The coenzyme form of Vitamin B1 present in many animal tissues. It is a required intermediate in the PYRUVATE DEHYDROGENASE COMPLEX and the KETOGLUTARATE DEHYDROGENASE COMPLEX.
A protective layer of firm, flexible cartilage over the articulating ends of bones. It provides a smooth surface for joint movement, protecting the ends of long bones from wear at points of contact.
A group of compounds with the general formula M10(PO4)6(OH)2, where M is barium, strontium, or calcium. The compounds are the principal mineral in phosphorite deposits, biological tissue, human bones, and teeth. They are also used as an anticaking agent and polymer catalysts. (Grant & Hackh's Chemical Dictionary, 5th ed)
A radionuclide imaging agent used primarily in scintigraphy or tomography of the heart to evaluate the extent of the necrotic myocardial process. It has also been used in noninvasive tests for the distribution of organ involvement in different types of amyloidosis and for the evaluation of muscle necrosis in the extremities.
Signal transduction mechanisms whereby calcium mobilization (from outside the cell or from intracellular storage pools) to the cytoplasm is triggered by external stimuli. Calcium signals are often seen to propagate as waves, oscillations, spikes, sparks, or puffs. The calcium acts as an intracellular messenger by activating calcium-responsive proteins.
Phosphoric or pyrophosphoric acid esters of polyisoprenoids.
The key substance in the biosynthesis of histidine, tryptophan, and purine and pyrimidine nucleotides.
Arthritis, especially of the great toe, as a result of gout. Acute gouty arthritis often is precipitated by trauma, infection, surgery, etc. The initial attacks are usually monoarticular but later attacks are often polyarticular.
The articulation between a metacarpal bone and a phalanx.
Benign unilocular lytic areas in the proximal end of a long bone with well defined and narrow endosteal margins. The cysts contain fluid and the cyst walls may contain some giant cells. Bone cysts usually occur in males between the ages 3-15 years.
Fibrocartilage that makes up the triangular fibrocartilage complex which is found in the WRIST JOINT.
A moon-shaped carpal bone which is located between the SCAPHOID BONE and TRIQUETRUM BONE.
The joint that is formed by the distal end of the RADIUS, the articular disc of the distal radioulnar joint, and the proximal row of CARPAL BONES; (SCAPHOID BONE; LUNATE BONE; triquetral bone).
A publication issued at stated, more or less regular, intervals.
"The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.
Chemicals used in agriculture. These include pesticides, fumigants, fertilizers, plant hormones, steroids, antibiotics, mycotoxins, etc.
A heterogeneous group of disorders, some hereditary, others acquired, characterized by abnormal structure or function of one or more of the elements of connective tissue, i.e., collagen, elastin, or the mucopolysaccharides.
A heterogeneous group of autosomally inherited COLLAGEN DISEASES caused by defects in the synthesis or structure of FIBRILLAR COLLAGEN. There are numerous subtypes: classical, hypermobility, vascular, and others. Common clinical features include hyperextensible skin and joints, skin fragility and reduced wound healing capability.
An autosomal dominant disorder of CONNECTIVE TISSUE with abnormal features in the heart, the eye, and the skeleton. Cardiovascular manifestations include MITRAL VALVE PROLAPSE, dilation of the AORTA, and aortic dissection. Other features include lens displacement (ectopia lentis), disproportioned long limbs and enlarged DURA MATER (dural ectasia). Marfan syndrome is associated with mutations in the gene encoding fibrillin, a major element of extracellular microfibrils of connective tissue.
Messages between computer users via COMPUTER COMMUNICATION NETWORKS. This feature duplicates most of the features of paper mail, such as forwarding, multiple copies, and attachments of images and other file types, but with a speed advantage. The term also refers to an individual message sent in this way.
The study of natural phenomena by observation, measurement, and experimentation.
Excessive URIC ACID or urate in blood as defined by its solubility in plasma at 37 degrees C; greater than 0.42mmol per liter (7.0mg/dL) in men or 0.36mmol per liter (6.0mg/dL) in women. This condition is caused by overproduction of uric acid or impaired renal clearance. Hyperuricemia can be acquired, drug-induced or genetically determined (LESCH-NYHAN SYNDROME). It is associated with HYPERTENSION and GOUT.
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
An enzyme that catalyzes the conversion of urate and unidentified products. It is a copper protein. The initial products decompose to form allantoin. EC 1.7.3.3.
A group of related diseases characterized by an unbalanced or disproportionate proliferation of immunoglobulin-producing cells, usually from a single clone. These cells frequently secrete a structurally homogeneous immunoglobulin (M-component) and/or an abnormal immunoglobulin.

Transduction mechanisms of porcine chondrocyte inorganic pyrophosphate elaboration. (1/116)

OBJECTIVE: To investigate cellular signaling mechanisms that influence chondrocyte production of inorganic pyrophosphate (PPi), which promotes calcium pyrophosphate dihydrate (CPPD) crystal deposition. METHODS: Articular chondrocyte and cartilage cultures were stimulated with protein kinase C (PKC) activator and adenyl cyclase activator. Generation of extracellular PPi was measured. RESULTS: Adenyl cyclase activation resulted in diminished pyrophosphate generation. PKC activation stimulated pyrophosphate elaboration. CONCLUSION: Two signaling pathways, cAMP and PKC, modulate generation of extracellular pyrophosphate by cartilage and chondrocytes. They are novel targets for potentially diminishing extracellular pyrophosphate elaboration that leads to CPPD crystal deposition.  (+info)

Myelopathy due to calcification of the cervical ligamenta flava: a report of two cases in West Indian patients. (2/116)

Two cases of cervical myelopathy due to calcification of the ligamenta flava (CLF) are described for the first time in black patients from the French West Indies. A pre-operative CT scan differentiated the diagnosis from one of ossification of the ligamenta flava. Microanalysis on the operatively excised specimen in one patient revealed a mixture of calcium pyrophosphate dihydrate crystals and hydroxypatite crystals. Poor outcome in one patient contrasting with excellent recovery in the other one, who had undergone posterior decompressive laminectomy, emphasizes the importance of surgery in the management of CLF.  (+info)

Most calcium pyrophosphate crystals appear as non-birefringent. (3/116)

OBJECTIVE: To determine the proportion of calcium pyrophosphate dihydrate (CPPD) crystals that appear as non-birefringent when observed under the polarised light microscope. METHODS: Two observers examined independently 10 synovial fluid samples obtained during an episode of arthritis attributable to CPPD crystals. Ten synovial fluid samples from patients with acute gout were used as a reference. The examination was performed after placing a fluid sample in a Niebauer haemocytometric chamber; a crystal count was done first under ordinary light, then in the area corresponding to a 0.1 ml, under polarised light RESULTS: The percentages of birefringence appreciated for CPPD were 18% (confidence intervals (CI) 12, 24) for observer 1, and 17% (CI 10, 24) for observer 2 (difference NS). The percentages of birefringence for monosodium urate were 127% (CI 103, 151) for observer 1 and 107% (CI 100, 114) for observer 2 (difference NS). Percentages above 100% indicate that crystals missed under ordinary light became apparent under polarised light. CONCLUSION: Only about one fifth of all CPPD crystals identified by bright field microscopy show birefringence when the same synovial fluid sample is observed under polarised light. If a search for CPPD crystals is conducted under polarised light, the majority of the crystals will be missed. Ordinary light allows a better rate of CPPD crystal detection but observation under polarised light of crystals showing birefringence is required for definitive CPPD crystal identification.  (+info)

Extracellular signal-regulated kinase 1/extracellular signal-regulated kinase 2 mitogen-activated protein kinase signaling and activation of activator protein 1 and nuclear factor kappaB transcription factors play central roles in interleukin-8 expression stimulated by monosodium urate monohydrate and calcium pyrophosphate crystals in monocytic cells. (4/116)

OBJECTIVE: Monosodium urate monohydrate (MSU) and calcium pyrophosphate dihydrate (CPPD) crystals cause acute gout and pseudogout, respectively. Because acute gout and pseudogout appear to be dependent on interleukin-8 (IL-8)-induced neutrophil ingress, this study was undertaken to define and compare how MSU and CPPD crystals stimulate IL-8 messenger RNA (mRNA) expression in mononuclear phagocytes. METHODS: MSU and CPPD crystal-induced mitogen-activated protein kinase (MAPK) signal transduction and IL-8 transcriptional activation were studied in human monocytic cells, using the THP-1 cell line. RESULTS: MSU and CPPD crystals (0.5 mg/ml) induced activation of c-Jun N-terminal kinase, extracellular signal-regulated kinase 1 (ERK-1)/ERK-2, and p38 MAPK pathways in THP-1 cells. Activation of the ERK-1/ERK-2 pathway was essential for MSU and CPPD crystal-induced IL-8 mRNA expression, whereas the p38 pathway played a greater role in IL-8 mRNA expression in response to CPPD crystals in comparison with MSU crystals. Both crystals induced the binding of nuclear factor kappaB (NF-kappaB), including the NF-kappaB complex c-Rel/RelA, and activator protein 1 (AP-1, including N-terminal phosphorylated c-Jun) to the IL-8 promoter. Both crystals induced transcriptional activation of the IL-8 promoter, which was dependent on activation of c-Rel/RelA and AP-1. Activation of the NF-IL-6 transcription factor played a lesser role. Finally, crystal-induced IL-8 promoter activation was mediated by activation of the ERK-1/ERK-2 pathway, as demonstrated by transfection of dominant-negative raf-1. CONCLUSION: These results indicate that ERK-1/ ERK-2 signaling and transcriptional activation through AP-1 and NF-kappaB are essential for the induction of IL-8 expression in mononuclear phagocytes in response to CPPD and MSU crystals.  (+info)

Calcification of the cervical ligamentum flavum--case report. (5/116)

A 52-year-old male presented with calcification of the cervical ligamentum flavum manifesting as hypesthesia of the bilateral middle, ring, and little fingers and ulnar halves of both forearms, as well as motor weakness in the bilateral upper extremities and gait disturbance. Cervical x-ray tomography detected a round calcified mass on the posterior wall of the cervical canal at the C-5 level. Computed tomography showed the round, nodular calcified mass more clearly. Magnetic resonance imaging showed an epidural low intensity mass compressing and distorting the cervical cord at the C-5 level on both T1- and T2-weighted images. Administration of gadolinium-diethylenetriaminepenta-acetic acid caused marginal enhancement of the mass. The lesion was eventually removed by posterior laminectomy. The mass was composed of a very hard crystal-like calcified deposition in the ligamentum flavum. X-ray diffraction analysis of the histological specimen showed calcium pyrophosphate dihydrate (CPPD) and hydroxyapatite in the crystal-like substance, confirming that CPPD is responsible for calcification of the cervical ligamentum flavum.  (+info)

Deposition of calcium pyrophosphate in tissue after revision arthroplasty of the hip. (6/116)

We reviewed histologically the incidence and pathogenesis of the deposition of calcium pyrophosphate dihydrate (CPPD) crystals in the pseudocapsule, femoral and acetabular membranes and periprosthetic tissue at revision of 789 cases of failed total hip replacement. In 13, periprosthetic tissues were found to have deposits of CPPD crystals in areas of cartilaginous metaplasia; four also showed evidence of localised deposition of amyloid. None of the patients had a history of chondrocalcinosis in the hip or other joints. Cartilaginous metaplasia and other changes in periprosthetic tissues may predispose to the deposition of CPPD and associated localised amyloid.  (+info)

Retro-odontoid massive calcium pyrophosphate crystal deposition--case report. (7/116)

An 86-year-old male presented with progressive myelopathy due to retro-odontoid massive deposits of calcium pyrophosphate dihydrate (CPPD) crystals. Magnetic resonance imaging revealed a non-enhanced isointense extradural mass on the T1-weighted image and heterogeneously intense mass on the T2-weighted image. Computed tomography showed typical punctate and linear calcifications within the mass. The mass was resected via a lateral approach resulting in marked improvement of the symptoms. Histological examination revealed birefringent rhomboid crystals consistent with CPPD. CPPD deposition should be considered in the differential diagnosis of retro-odontoid extradural mass because surgical therapy is beneficial even for elderly patients.  (+info)

Inhibition of TNF-alpha-induced neutrophil apoptosis by crystals of calcium pyrophosphate dihydrate is mediated by the extracellular signal-regulated kinase and phosphatidylinositol 3-kinase/Akt pathways up-stream of caspase 3. (8/116)

The role of protein kinases in the inhibition of TNF-alpha associated apoptosis of human neutrophils by crystals of calcium pyrophosphate dihydrate (CPPD) (25 mg/ml) was investigated. We monitored the activities of the p44 extracellular signal-regulated kinase 1 (ERK1) and p42 ERK2 mitogen-activated protein (MAP) kinases and phosphatidylinositol 3-kinase (PI3-K)-regulated protein kinase B (Akt) in neutrophils incubated with TNF-alpha and CPPD crystals, separately and in combination, in parallel with the endogenous caspase 3 activity and DNA fragmentation. CPPD crystals were observed to induce a robust and transient activation of ERK1, ERK2, and Akt, whereas TNF-alpha produced only a modest and delayed activation of Akt. In the presence of TNF-alpha, Akt activity was enhanced, and CPPD crystal-induced activation of ERK1 and ERK2 was more sustained than with CPPD crystals alone, but TNF-alpha itself reduced the basal phosphotransferase activities of these MAP kinases. Preincubation with the MAP kinase kinase (MEK1) inhibitors PD98059 (20 ng/ml) and U0126 (250 nM), or the PI3-K inhibitors wortmannin (100 nM) and LY294002 (50 microM) repressed the activation of ERK1, ERK2, and Akt in association with CPPD crystal incubation, in the absence or presence of TNF-alpha. Furthermore, the inhibition of the Mek1/Mek2-->ERK1/ERK2 or PI3-K/Akt pathways reversed CPPD crystal-associated suppression of TNF-alpha-induced caspase 3 activation and neutrophil apoptosis. Together, these results indicate that CPPD crystals function to induce acute inflammatory responses through ERK1/ERK2 and PI3-K/Akt-mediated stimulation of neutrophil activation and repression of apoptosis.  (+info)

Learn more about Calcium Pyrophosphate Dihydrate Deposition Disease at Medical City Dallas DefinitionCausesRisk FactorsSymptomsDiagnosisTreatmentPreventionrevision ...
Precipitation of crystals of calcium pyrophosphate dihydrate (CPP) in connective tissues may be asymptomatic or may be associated with several clinical syndromes. These disorders, including acute inflammatory, chronic inflammatory, and degenerative a
Mg is a divalent cation mostly located intracellularly. It plays an important role in enzymatic processes. In healthy individuals homeostasis of Mg is regulated effectively, as sufficient mechanisms in the gastrointestinal tract and the kidney exist. However, if these mechanisms are affected in underlying disease, Mg depletion can cause a wide range of symptoms such as neuromuscular manifestations (muscular cramps, vertigo, tetany), cardiac and vascular manifestations (arrhythmias, hypertension), metabolic sequels and psychiatric manifestations (depression, fatigue) [11, 12].. As seen in this case, severe Mg depletion resulted in CPPD deposition with clinical manifestations of chronic inflammatory arthritis [13-16] and was responsible for muscular weakness, fatigue and the depressive episode.. Chondrocalcinosis, is defined as the deposition of calcium pyrophosphate dihydrate in hyaline or fibrous cartilage [14]. In radiography delicate linear calcification of the cartilage can be seen. The ...
Calcium deposition is often seen at the triangular fibrocartilage of the wrist. Subchondral sclerosis, joint space narrowing, subchondral cyst formations which may be quite large, and intraarticular bodies from subchondral osseous collapse and fragmentation are all findings which can be seen in patients with CPPD disease. These radiographic abnormalities are most common at the radiocarpal articulation and at the 2nd and 3rd metacarpophalangeal joints. Additionally, there may a shift in the normal alignment of the scaphoid and lunate and narrowing at the midcarpal compartment. Differential Diagnosis:. CPPD disease causes destruction of cartilage which can lead to radiographic findings similar to osteoarthritis. Sites of involvement are useful for differentiating the two since the radiocarpal compartment of the wrist is not a common location for osteoarthritis. Lack of an erosive process at the MCP joint differentiates CPPD crystal deposition disease from rheumatoid arthritis. Greater propensity ...
Milwaukee shoulder syndrome (apatite-associated destructive arthritis) is a rheumatological condition similar to calcium pyrophosphate dihydrate deposition disease (CPPD). It is associated with periarticular or intraarticular deposition of hydroxyapatite crystals. Crystal deposition in the joint causes the release of collagenases, serine proteases, elastases, and interleukin-1. This precipitates acute and rapid decline in joint function and degradation of joint anatomy. Subsequently disruption of the rotator cuff ensues. Along with symptomatology, the disease typically presents with positive radiologic findings, often showing marked erosion of the humeral head, cartilage, capsule, and bursae. Though rare, it is most often seen in females beginning in their 50s or 60s. Diagnosis is made with arthrocentesis and Alizarin Red staining along with clinical symptoms. Signs and symptoms may include the following: Limited active range of motion, usually unrestricted passive range of movement (early) ...
Support group for people who have Angiomyolipoma and experience Calcium Pyrophosphate Dihydrate Deposition Disease, created by eHealthMe (http://www.eHealthMe.com). To join the group, do any of these: create a post to introduce yourself, ask a question, or simply follow the group.. submitted on 6 months 1 week ago by eHealthMe.com ...
The interaction of particulates with resident macrophages is a consistent feature in certain forms of crystal-induced inflammation, for example, in synovial tissues, lung, and the peritoneum. The mitogenic activity of basic calcium phosphate (BCP) crystals and calcium pyrophosphate dihydrate (CPPD) crystals on synovial fibroblasts has been considered relevant to the synovial hyperplasia observed in crystal-induced arthritis. The aim of the study was to determine whether microcrystals such as these could enhance macrophage survival and induce DNA synthesis, thus indicating that they may contribute to the tissue hyperplasia. Murine bone-marrow-derived macrophages were treated in vitro with microcrystals, the cell numbers were monitored over time, and DNA synthesis was measured as the incorporation of [methyl-3H]thymidine (TdR). We report here that BCP, monosodium urate, talc, and, to a lesser extent, CPPD crystals promote macrophage survival and DNA synthesis; the latter response is particularly striking
Methods A web-based exercise and subsequent patient-based exercise were carried out. A panel of 30 OMERACT members, participated at the web-based exercise by evaluating twice a set of US images for the presence/absence of CPPD. Afterwards, 19 members of the panel met in Siena, Italy, for the patient-based exercise. During the exercise, all sonographers examined twice eight patients for the presence/absence of CPPD at the same joints. Intraoberserver and interobserver kappa values were calculated for both exercises. ...
Osteoarthritis is a common feature, most often affecting the knees, shoulders, hips, and hands. Single or multiple joints may be affected. Hypertrophy of cartilage initially produces radiographic widening of the joint space. The newly synthesized cartilage is abnormally susceptible to fissuring, ulceration, and destruction. Ligamental laxity of joints further contributes to the development of osteoarthritis. Cartilage degrades, the joint space narrows, and subchondral sclerosis and osteophytes develop. Joint examination reveals crepitus and laxity. Joint fluid is noninflammatory. Calcium pyrophosphate dihydrate crystals are found in the cartilage in some cases of acromegaly arthropathy and, when shed into the joint, can elicit attacks of pseudogout. Chondrocalcinosis may be observed on radiographs. Back pain is extremely common, perhaps as a result of spine hypermobility. Spine radiographs show normal or widened intervertebral disk spaces, hypertrophic anterior osteophytes, and ligamental ...
Iron was readily demonstrated in chondrocytes in 3 of 4 hemochromatosis articular cartilages studied. Either apatite, calcium pyrophosphate dihydrate crystals, or both were found in all cartilages including those of 3 patients who had no radiographic or light microscopic evidence of calcification. These crystals, which may be secondary to degenerative changes or may play a role in cartilage degeneration, were not seen in any consistent morphologic relationship with the iron deposits. In fact, apatite was found in one cartilage in which no iron was identified in the sections studied. If iron, as demonstrated in the chondrocytes, is contributing to the calcium crystal deposition, it would most likely do so indirectly, for example by altering chondrocyte enzymes or connective tissue components.
Calcium Pyrophosphate Arthritis - Etiology, pathophysiology, symptoms, signs, diagnosis & prognosis from the Merck Manuals - Medical Professional Version.
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Psuedogout, also referred to as calcium pyrophosphate deposition disease, or CPDD, is a form of arthritis caused by crystal deposits in joints. The American College of Rheumatology states there is no...
Rheumatoid Arthritis is an auto-immune disease in which our immune system mistakenly attacks healthy joint tissue. It causes swelling, pain and eventually joint deformities. The inflammation can spread to the surrounding tissues and damage cartilage and bones. About 21 million people are affected by this disease globally each year.. Gout & Calcium Pyrophosphate Deposition Disease (CPPD) are caused by excess uric acid and calcium salt respectively, forming crystals in joints and causing inflammation, redness and swelling. Causes are unclear, but the risk increases with age and the disease is often misdiagnosed as arthritis. ...
Pain is an unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage
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OBJECTIVE: To test the hypothesis that high concentrations of extracellular inorganic pyrophosphate (PPi), which associate with increased cell synthesis and turnover in cartilage, may act as a marker for structural outcome in knee osteoarthritis (OA). METHOD: One hundred and thirty five consecutive patients referred to hospital with knee OA (59 men, 76 women; mean age 71 years, range 41-88) were followed prospectively for a median of 2.5 years (interquartile range 1.75-3.0). Synovial fluid (SF) aspirated at presentation (202 OA knees: 68 bilateral, 66 unilateral) was assessed for PPi content by radiometric assay. Knee radiographs at presentation and at final review were assessed for change in global (Kellgren) and individual features (narrowing, osteophyte, sclerosis, cyst, attrition) of OA. RESULTS: The median SF PPi level was 10.5 mumol (range 0.07-72.4). At baseline, high PPi was significantly associated with presence of calcium pyrophosphate crystals, chondrocalcinosis, and bone attrition. ...
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Many crystals have been associated with arthropathies or periarticular syndromes: only monosodium urate monohydrate (gout), calcium pyrophosphate dehydrate (pseudogout, chondrocalcinosis), and basic calcium phosphates (mainly hydroxyapatite) are common.Crystals implicated in joint disease are stable, hard particles that exert biological effects via surface-active (activation of humoral and cell-derived mediators, interaction with cell membranes) and mechanical properties. In general, smaller particle size, marked surface irregularity, and high negative surface charge correlate with inflammatory potential....
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Chronic CPP crystal inflammatory arthritis: Chronic inflammatory oligoarthritis or polyarthritis associated with CPPD. Patients have occasional systemic upset with elevation of CRP and ESR and superimposed flares with characteristics of crystal inflammation (see above). Differential considerations include rheumatoid arthritis and other chronic inflammatory joint diseases in older adults. Imaging findings are similar to those of osteoarthritis, but the dirstribution within the joint is different, with CPPD affecting non-weight-bearing surfaces of joints. It is also usually bilateral and symmetric. Synovial inflammation and joint effusions can also be seen. Osteophytes and osteochondral bodies are commonly present. Subchondral cysts are more prominent than in osteoarthritis, and may form before cartilage loss is radiographically evident. Risk factors for calcium pyrophosphate arthropathy are aging, osteoarthritis, previous joint trauma, metabolic diseases (e.g., the four Hs: hemochromatosis, ...
Definition It is a crystal deposition of calcium pyrophosphate dehydrate (CPPD) in cartilage (chondrocalcinosis). It is a common age associated phenomenon (|55) that particularly targets the knee . Aetiology (Causes)
A few months ago I rather suddenly developed an acute painful swelling at the base of my left big toe. I think Im having an attack of gout, but why me? I wondered. Of course this had to happen on a weekend, when the Family Practice Clinic Id usually go to was closed, as was my Podiatrists office.. I wondered if I could have septic arthritis, an infected joint, but had no obvious reason for this much more frightening diagnosis. I remembered there was also an entity called pseudogout, where the crystals were calcium pyrophosphate, not uric acid.. So I went to the Urgent Care Center our local hospital established a few blocks away from my house. A Family Practice physician examined me and said, I think you have gout, but youll need to go to the hospitals Emergency Department (ED) so they can get some fluid from your joint and decide if its really gout. We dont do that test here. She was also concerned about the rather slim possibility of septic arthritis.. At the ED I was triaged as ...
Methods. This was a prospective, longitudinal, observational factorial study, analyzing 30 SF samples: 12 with monosodium urate (MSU) crystals and 18 with calcium pyrophosphate (CPP) crystals. Each SF sample was divided into 4 subsamples (120 subsamples in total). Two were stored in each type of preserving agent, heparin or ethylenediamine tetraacetic acid (EDTA), at room temperature or at 4°C. Samples were analyzed the following day (T1), at 3 days (T2), and at 7 days (T3) by simple polarized light microscopy, and the presence of crystals was recorded. ...
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C~0H~gN5Os.2H20, Mr=325.32, monoclinic,P2~, a = 12.029 (2), b=4.904 (2), c=13.215 (2) A, fl= 107.68 (2) ° , F= 743 (1) A 3, Z= 2,D m = 1-45, D x = 1.45 Mg m -3, Cu Ka, 2 = 1.54184 A,fl= 1.01mm -1, F(000)=348, T=293K. The final R value for 1277 observed reflections 110 ,_ 3tr(Io)l is 0.031. The dipeptide exists as a zwitterion. The arginyl side-chain conformation is similar to that found in arginyl-glutamic acid [Pandit, Seshadri & Viswamitra (1983). Acta Cryst. C39, 1669-16721. The guanidyl group forms a pair of hydrogen bonds with oxygen atoms of the backbone carboxyl group. The crystal structure is also stabilized by -bonding interactions involving both water molecules.. ...
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Calcium pyrophosphate dihydrate crystals are associated with a range of clinical syndromes, which have been given various names, based upon which clinical symptoms or radiographic findings are most prominent.[11] A task force of the European League Against Rheumatism (EULAR) made recommendations on preferred terminology.[5] Accordingly, calcium pyrophosphate deposition (CPPD) is an umbrella term for the various clinical subsets, whose naming reflects an emphasis on particular features. For example, pseudogout refers to the acute symptoms of joint inflammation or synovitis: red, tender, and swollen joints that may resemble gouty arthritis (a similar condition in which monosodium urate crystals are deposited within the joints). Chondrocalcinosis,[2][3] on the other hand, refers to the radiographic evidence of calcification in hyaline and/or fibrocartilage. Osteoarthritis (OA) with CPPD reflects a situation where osteoarthritis features are the most apparent. Pyrophosphate arthropathy refers to ...
Synonyms: Pseudogout, chondrocalcinosis, pyrophosphate arthropathy.. ICD-9 Codes: Pseudogout, 712.2; CPPD crystal deposition disease, 712.2; chondrocalcinosis, 712.3.. Definition: CPPD crystal deposition disease includes arthritic syndromes associated with CPPD crystal deposition disease in articular tissues. The following definitions are used here:. -Chondrocalcinosis: Calcification of articular cartilage (identified by x-ray).. -Chronic CPPD crystal deposition disease: Structural bone and cartilage abnormalities associated with intraarticular deposition of CPPD crystals.. -Pseudogout: Clinical syndrome of acute synovitis caused by intraarticular CPPD crystal deposition, the most common form of CPPD crystal deposition disease.. Etiology: The cause of CPPD crystal deposition disease is unknown. Formation of CPPD crystals in cartilage may be related to matrix changes or result from elevated levels of calcium or inorganic pyrophosphate. Some cases appear to be hereditary, whereas others are ...
Chondrocalcinosis (CC) most commonly results from calcium pyrophosphate crystal deposition (CPPD). The objective of this study is to examine the association between candidate single-nucleotide polymorphisms (SNPs) and radiographic CC. SNPs in ankylosis human (ANKH), high ferritin (HFE), tissue non-specific alkaline phosphatase (TNAP), ecto-neucleotide pyrophosphatase 1 (ENPP1), and transferrin (TE) genes were genotyped in participants of the Genetics of Osteoarthritis and Lifestyle (GOAL) and Nottingham Osteoarthritis Case-Control studies. Adjusted genotype odds ratio (aORGENOTYPE), the OR for association between one additional minor allele and CC, was calculated and adjusted for age, gender, body mass index (BMI), and osteoarthritis (OA) by using binary logistic regression. Statistical significance was set at P ≤0.003 after Bonferroni correction for multiple tests. The -4bpG | A polymorphism in the 5′ untranslated region (5′ UTR) of ANKH associated with CC after Bonferroni correction. This was
Pseudogout is a type of arthritis that, as the name implies, can cause symptoms similar to gout, but which are a reaction to a different type of crystal deposit. This type of arthritis may be one of the most misunderstood forms, and is often mistaken for gout and other conditions, including RA. Proper diagnosis is important because untreated pseudogout may lead to a severe form of joint degeneration and ongoing inflammation, resulting in chronic disability.. Pseudogout develops when deposits of calcium pyrophosphate crystals accumulate in a joint. Initially, crystals deposit in the cartilage and can cause damage. They also can cause a reaction with inflammation that leads to joint pain and swelling. This can cause more chronic arthritis that mimics osteoarthritis or RA. Knees are most often involved, but wrists, shoulders, ankles, elbows, and hands can be affected. Ultimately, a patient with pseudogout could be incapacitated for days or weeks.. ...
Basic Calcium Phosphate Crystals Induce Osteoarthritis-Associated Changes in Chondrocyte Phenotype through Activation of Calcium/Calmodulin Kinase ...
The crowned dens syndrome (CDS), also known as periodontoid calcium pyrophosphate dehydrate crystal deposition disease, is typified clinically by severe cervical pain, neck stiffness and atlantoaxial synovial calcification which could be misdiagnosed
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Mohammad Sami Walid 1, Joshua C. Yelverton 2, Mohammed Ajjan 3, Arthur A. Grigorian 3. Medical Center of Central Georgia 1, Mercer University 2, Georgia Neurosurgical Institute 3, USA. Abstract. Objective & Importance: Crystal-induced arthritis (gout and pseudogout) usually affects peripheral joints whereas spine involvement with severe myelopathy is extremely rare. PubMed search yielded 42 results for gout myelopathy and 35 results for pseudogout myelopathy .. Clinical Presentation: We are reporting the case of a 62 years old female Caucasian who presented with severe thoracic myelopathy. MRI of the spine with contrast showed a 1.0´1.7 cm epidural soft tissue nodule with peripheral enhancement posterior to the thoracic cord at T9-10.. Intervention: Decompression and excision of the lesion was performed. Pathology revealed rhomboid-shaped, positively birefringent crystals. Uric acid was normal. The diagnosis of pseudogout was established.. Conclusion: Spinal crystal arthropathy should be ...
All clinicians know about the complexity in diagnosing rheumatoid arthritis (RA), especially early in the disease. Because RA lacks pathognomonic features - that is, there are no clinical, biological, or radiological characteristics specific to RA diagnosis - doubt about the diagnosis may persist for some patients1,2. Examples are patients with nude polyarthritis [i.e., without positivity for serum rheumatoid factor (RF), anti-citrullinated peptide antibodies, typical erosion, or all 3], or even elderly people with erosive RF-positive polyarthritis associated with psoriasis or calcium crystal deposition disease features seen on joint radiography. When RA is neither obvious nor completely excluded, the clinician strikes a balance between possible or probable RA, depending on the level of confidence. In this context, in clinical research, RA classification criteria may be of some help because they ensure, at the group level, the diagnosis of RA with minimal error. However, in clinical practice, ...
Histopathological and ultrastructural studies of synovium in Milwaukee shoulder syndrome--a basic calcium phosphate crystal arthropathy.: Light and electron mic
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Foscarnet sodium is an antiviral drug for the treatment of CMV retinitis, currently in the form of twice-weekly intravitreal injection. Here we developed foscarnet calcium microcrystals as the drug depot, and using the rabbit model we demonstrated that the injected microcrystals maintained a therapeutically
The films of glycine consisting of isolated microcrystals were prepared by spin coating and drying of the aqueous solution. Drying leads to dewetting (arising and growth of the holes) and formation of quasi-regular arrays of microcrystals that form the net structure consisting of Voronoi cells. The time dependence of the hole boundary velocity leading to formation of the straight net segments was proposed. Numerical model of hole nucleation and growth by boundary motion was proposed for the computer simulation. The coincidence of the simulated structures obtained within Kolmogorov alpha-model with experimental structures confirmed the validity of proposed approach ...
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Calcium chloride dihydrate in alcohol, lidocaine, or saline solution has been extensively studied for nonsurgical neuter for male animals. However, when...
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Of note in this discussion, however, is the immune systems response to the presence of calcium crystals in developing atherosclerotic lesions in arteries. Cells called macrophages which are first responders to bodily harm show up early in the course of blood vessel injury and set immediately to work eating foreign invaders Pac-Man style. As they gobble up various harmful substances such as oxidized LDL cholesterol or basic calcium phosphate (BCP) crystals, they send out proinflammatory cytokines which are chemical messenger molecules that further activate an immune response. This is a good thing with regards to incoming foreign bodies such as bacteria or dirt from the sidewalk when youve fallen and scraped your knee, but not so good when its an ongoing assault from various environmental insults such as LDL-cholesterol, trans-fats, cigarette smoke, or...too much calcium (more on this later). The inflammation from BCP crystals in activated macrophages may lead to a positive feed-back loop of ...
Optimization for stoichiometric and morphology-controlled calcium phosphate crystals from bio-bearing calcium phosphate (BCP) under hydrothermal conditions ...
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Product Number , 53963291. CAS Number , 6138-23-4. EC , 202-739-6. Molecular Formula , C12H22O112H2O. Molecular Weight , 378.33. Storage Temp , +20°C. Harmonized Tariff code , 2940000080. Signal Word , ...
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Developed by a Mexican specialists, this resin inhibits growth, reproduction and transfer of yeast and fungi, used as cement it can adhere to metal surfaces, glass or ceramics. Through an an... Read more ...
Methods of forming potassium sulfate include calcining polyhalite ore particles to convert the polyhalite ore particles to a water-soluble composition. At least a portion of the water-soluble composition is dissolved in an aqueous medium to form an aqueous solution comprising K+, Mg2+, and SO4 2− ions and a calcium-containing solid. The calcium-containing solid is separated from the aqueous solution to form a filtrate comprising K+, Mg2+, and SO4 2− ions. A potassium-containing salt is dissolved in the filtrate to increase the concentration of K+ and SO4 2− ions to from a concentrated liquor, and K2SO4 is crystallized from the concentrated liquor. A system for processing polyhalite ore includes a countercurrent leaching apparatus, a first mix tank, an evaporator, and at least one crystallizer.
Rothschild, Bruce M Calcium Pyrophosphate Deposition Disease (radiology) Hubert, Jan; Weiser, Lukas; Hischke, Sandra; Uhlig, ... Wright GD, Doherty M (1997). "Calcium pyrophosphate crystal deposition is not always 'wear and tear' or aging". Ann. Rheum. Dis ... Another common cause of chondrocalcinosis is calcium pyrophosphate dihydrate crystal deposition disease (CPPD). CPPD is ... "Clinical manifestations and diagnosis of calcium pyrophosphate crystal deposition (CPPD) disease". UpToDate. This topic last ...
Sodium pyrophosphate Calcium pyrophosphate dihydrate deposition disease Dimethylallyl pyrophosphate ADP ATP Ortho acids ... It is best prepared by ion exchange from sodium pyrophosphate or by treating lead pyrophosphate with hydrogen sulfide. It is ... Anions, salts, and esters of pyrophosphoric acid are called pyrophosphates. ... except that it is a component of polyphosphoric acid and the conjugate acid of the pyrophosphate anion. ...
In a type of arthritis called pseudogout, crystals of calcium pyrophosphate dihydrate accumulate in the joint, causing ...
... is a rheumatological condition similar to calcium pyrophosphate dihydrate deposition disease (CPPD). It is associated with ...
Calcium pyrophosphate Other cations. Magnesium phosphate. Dicalcium phosphate. Tricalcium phosphate. Strontium phosphate ... Acid calcium phosphate. Calcium acid phosphate. Calcium diorthophosphate. Calcium biphosphate. Calcium superphosphate. ... Calcium dihydrogen phosphate is used in the food industry as a leavening agent, i.e., to cause baked goods to rise. Because it ... In double acting baking powders, MCP is often combined with the slow acting acid sodium acid pyrophosphate (SAPP).[3] ...
Calcium pyrophosphate. Other cations. Magnesium phosphate. Dicalcium phosphate. Tricalcium phosphate. Strontium phosphate. ... Acid calcium phosphate. Calcium acid phosphate. Calcium diorthophosphate. Calcium biphosphate. Calcium superphosphate. ... Calcium dihydrogen phosphate is used in the food industry as a leavening agent, i.e., to cause baked goods to rise. Because it ... Material of relatively high purity, as required for baking, is produced by treating calcium hydroxide with phosphoric acid:. Ca ...
... may refer to: Calcium pyrophosphate dihydrate crystal deposition disease Certified Practising Project Director This ...
... and pyrophosphates as well as high concentrations of cations, particularly calcium. These granules derive their name from their ...
The danger molecule can be extracellular ATP, extracellular glucose, crystals of monosodium urate (MSU), calcium pyrophosphate ...
... while secondary osteoarthritis due to calcium pyrophosphate deposition can be diagnosed when calcification of hyaline cartilage ...
... where Tissot suspected the presence of calcium pyrophosphate. Thomas was the first to discover phosphates in the province of ...
"Kinetics of Growth of Columnar Triclinic Calcium Pyrophosphate Dihydrate Crystals". Crystal Growth & Design. 1 (6): 463-466. ...
... is an ingredient in some baking powders containing sodium acid pyrophosphate. It provides calcium in order to ... Calcium lactate can be prepared by the reaction of lactic acid with calcium carbonate or calcium hydroxide. Since the 19th ... Calcium lactate has several uses in human and veterinary medicine. Calcium lactate is used in medicine as an antacid. Calcium ... Calcium lactate gluconate Calcium gluconate Calcium citrate Martina Vavrusova, Merete Bøgelund Munk, and Leif H. Skibsted (2013 ...
In toothpaste and dental floss, tetrasodium pyrophosphate acts as a tartar control agent, serving to remove calcium and ... Tetrasodium pyrophosphate, also called sodium pyrophosphate, tetrasodium phosphate or TSPP, is an inorganic compound with the ... Tetrasodium pyrophosphate is sometimes used in household detergents to prevent similar deposition on clothing, but due to its ... Tetrasodium pyrophosphate is produced by the reaction of furnace-grade phosphoric acid with sodium carbonate to form disodium ...
An alternative to the wet procedure entails heating a mixture of a calcium pyrophosphate and calcium carbonate: CaCO3 + Ca2P2O7 ... Calcium phosphate is one of the main combustion products of bone (see bone ash). Calcium phosphate is also commonly derived ... The high temperature forms each have two types of columns, one containing only calcium ions and the other both calcium and ... Calcium phosphate refers to numerous materials consisting of calcium ions (Ca2+) together with orthophosphates (PO43−), ...
... there is a less common form of gout that is caused by the formation of rhomboidal-shaped crystals of calcium pyrophosphate. ...
Sodium Acid Pyrophosphate, Monocalcium Phosphate, Sodium Phosphate ), Salt, Corn Syrup Solids, Calcium Carbonate, Corn Starch, ... Calcium Sulphate, Dextrose, Soy Lecithin, Polysorbate 60, Mono and Diglycerides, Cellulose Gum, Calcium Caseinate, Wheat Gluten ...
... such as uric acid or calcium pyrophosphate dihydrate ram crystals found in gout or pseudogout. ...
... sodium pyrophosphate or trimagnesium phosphate octahydrate are added when for example, dibasic calcium phosphate dihydrate is ... Dibasic calcium phosphate is also found in some dietary calcium supplements (e.g. Bonexcin). It is used in poultry feed. It is ... Dibasic calcium phosphate is produced by the neutralization of calcium hydroxide with phosphoric acid, which precipitates the ... Dibasic calcium phosphate dihydrate is formed in "brushite" calcium phosphate cements (CPC's), which have medical applications ...
a b c d e f g h i j k l m n Rothschild, Bruce M Calcium Pyrophosphate Deposition Disease (rheumatology) at eMedicine ... Calcium pyrophosphate dihydrate (CPPD) crystal deposition disease, also known as pseudogout and pyrophosphate arthropathy, is a ... Calcium pyrophosphate dihydrate crystal deposition disease. From Wikipedia, the free encyclopedia. (Redirected from Calcium ... a b c d Rothschild, Bruce M Calcium Pyrophosphate Deposition Disease (radiology) ...
Calcium compounds and aluminium compounds do not have that problem, though, since calcium compounds that deprotonate twice are ... It contained sodium acid pyrophosphate and cornstarch and was labeled as a leavening agent. It could be substituted for cream ... In 1864, he obtained a patent for a self-rising flour or "Bread preparation" in which calcium acid phosphate and sodium ... Smith also sold a baking powder replacement, in which sodium acid pyrophosphate was already mixed with bicarbonate of soda and ...
Studied the use of the paratungstate and pyrophosphate ions in analysis. Developed a series of methods for estimating various ... and the estimation of boric acid by distillation with methanol and fixation by calcium oxide. Developed methods for estimating ...
NaGly was shown to be endogenous ligand for the G-protein couple receptor GPR92 along with farnesyl pyrophosphate. In the ... NaGly was identified as a novel insulin secretagogue and was shown to increase intracellular calcium concentration through ... "Identification of farnesyl pyrophosphate and N-arachidonylglycine as endogenous ligands for GPR92". The Journal of Biological ... dorsal root ganglia (DRG), where GPR92 was found to be localized NaGly increased intracellular calcium levels in DRG neurons, ...
... calcium carbonate, soy lecithin, vitamins B6, C, D3, and K, vitamins A and E as acetate, taurine, ferrous sulfate, zinc sulfate ... as ferric pyrophosphate), and zinc sulfate. Nido 1+ contains: nonfat milk, vegetable oils (corn, canola, palm), sugar, ... niacinamide, thiamine mononitrate, folic acid, biotin, calcium pantothenate, and sodium selenate. Nido Dry Whole Milk (product ...
But while pyrophosphate inhibits both osteoclastic bone resorption and the mineralization of the bone newly formed by ... In laboratory tests, decreased calcium and phosphate values may be seen but reflect expected action of the drug and are almost ... For optimal action, enough calcium and vitamin D are needed in the body in order to promote normal bone development. ... Use is often recommended together with vitamin D, calcium supplementation, and lifestyle changes. Common side effects (1 to 10 ...
In 1836 he discovered sodium pyrophosphate. Clark is best known by his hard water tests and by his process for softening chalk ... His other major invention was the process of softening waters rendered hard by the presence of calcium bicarbonate in solution ...
... with loss of pyrophosphate. Glycerol-3-phosphate reacts with CDP-diacylglycerol to form phosphatidylglycerol phosphate, while ... "Interaction of the lipid and protein components of pulmonarysurfactant Role of phosphatidylglycerol and calcium". Biochimica et ...
... which in turn increases intracellular calcium by passively decreasing the action of the sodium-calcium exchanger in the ... is related to thiamine deficiency because magnesium is needed for transforming thiamine into thiamine pyrophosphate. Loop and ... This results in loss of magnesium and calcium in the urine. Mitochondriopathies, such as caused by mutations in SARS2, MT-TI or ... The increased intracellular calcium gives a positive inotropic effect. Adrenergics, displace magnesium into the cell Cisplatin ...
Tooth enamel consists mostly of calcium hydroxyphosphate, Ca5(PO4)3OH, also known as the mineral hydroxyapatite. Apatite is a ... NaMFP can also be prepared by treating tetrasodium pyrophosphate or disodium phosphate with hydrogen fluoride. In the ... Na2PO3F The process involves scission of a pyrophosphate bond, analogous to hydrolysis. ...
Calcium perchlorate - Ca(ClO4)2. *Calcium permanganate - Ca(MnO4)2 ... Zinc pyrophosphate - Zn2P2O7. *Zinc selenate - ZnSeO4 ... Calcium sulfate (gypsum) - CaSO4. C[edit]. *Carbon dioxide - CO ...
One example is sodium pyrophosphate, which acts on casein in milk during the preparation of instant pudding. ... Alginic acid (E400), sodium alginate (E401), potassium alginate (E402), ammonium alginate (E403), calcium alginate (E404) - ... LM Pectin reacts with calcium, and is used for the preparation of low sugar jams.[2] ... Sulfonates - Sodium or calcium salts, good water retention, versatile, and highly efficient. ...
Calcium and magnesium have been shown to affect the distribution of thiamine in the body and magnesium deficiency has been ... The synthesis of thiamine diphosphate (ThDP), also known as thiamine pyrophosphate (TPP) or cocarboxylase, is catalyzed by an ... The best-characterized form is thiamine pyrophosphate (TPP), a coenzyme in the catabolism of sugars and amino acids. In yeast, ... also sometimes called thiamine pyrophosphate (TPP), thiamine triphosphate (ThTP), the recently discovered adenosine thiamine ...
Its active form is a coenzyme called thiamine pyrophosphate (TPP), which takes part in the conversion of pyruvate to acetyl ...
DRIs for Calcium and Vitamin D Archived 2010-12-24 at the Wayback Machine ... This is important for maintaining calcium levels and promoting bone health and development.[8] As a medication, cholecalciferol ... Institute of Medicine (US) Committee to Review Dietary Reference Intakes for Vitamin D and, Calcium; Ross, AC; Taylor, CL; ... Jolly SE, Henderson RJ, Frampton C, Eason CT (1995). "Cholecalciferol Toxicity and Its Enhancement by Calcium Carbonate in the ...
Gradual calcium deposition within collagen occurs as a natural function of aging. Calcified points within collagen matrices ... "Binding of Phosphate and pyrophosphate ions at the active site of human angiogenin as revealed by X-ray crystallography" ...
Guse AH «Regulation of calcium signaling by the second messenger cyclic adenosine diphosphoribose (cADPR)». Curr. Mol. Med., 4 ... Kornberg, A. «The participation of inorganic pyrophosphate in the reversible enzymatic synthesis of diphosphopyridine ... Clapper DL, Walseth TF, Dargie PJ, Lee HC «Pyridine nucleotide metabolites stimulate calcium release from sea urchin egg ...
... which is involved in triggering calcium signals by the release of calcium from intracellular stores.[24] This form of signal ... Lohmann, K. (August 1929). "Über die Pyrophosphatfraktion im Muskel" [On the pyrophosphate fraction in muscle]. ... or pyrophosphate (PPi) unit from ATP at standard state of 1 M are:[13] ... to NADH and the concentrations of calcium, inorganic phosphate, ATP, ADP, and AMP. Citrate - the molecule that gives its name ...
Regulation by calcium. Calcium is also used as a regulator in the citric acid cycle. Calcium levels in the mitochondrial matrix ... dehydrogenase, Thiamine pyrophosphate, Lipoic acid, Mg++,transsuccinytase Oxidative. decarboxylation irreversible stage, ... Calcium also activates isocitrate dehydrogenase and α-ketoglutarate dehydrogenase.[34] This increases the reaction rate of many ...
This works to alter the calcium sensitivity of the neuron by allowing mutant RETGC-1 to be activated by GCAP at higher calcium ... and pyrophosphate: *. ... Also, calcium is linked to apoptosis by causing the release of ... this mutation causes extremely high intracellular calcium levels. Calcium, which plays many roles in the cell and is tightly ... In response to calcium levels, guanylate cyclase synthesizes cGMP from GTP. cGMP keeps cGMP-gated channels open, allowing for ...
... which induces the release of calcium into the cytosol. Low calcium in the endoplasmic reticulum causes STIM1 clustering on the ... The most common phosphoantigens from animal and human cells (including cancer cells) are isopentenyl pyrophosphate (IPP) and ... This aggregated cytosolic calcium binds calmodulin, which can then activate calcineurin. Calcineurin, in turn, activates NFAT, ... IP3 is released from the membrane by PLC-γ and diffuses rapidly to activate calcium channel receptors on the ER, ...
Esta molécula actúa na sinalización de calcio liberando calcio das reservas intracelulares.[59] Isto realízao uníndose e ... "The participation of inorganic pyrophosphate in the reversible enzymatic synthesis of diphosphopyridine nucleotide" (PDF). J. ... Guse AH (2004). "Regulation of calcium signaling by the second messenger cyclic adenosine diphosphoribose (cADPR)". Curr. Mol. ... abrindo unha clase de canles de calcio chamadas receptores de rianodina, que se encontran localizadas nas membranas de ...
Klein C, Malviya AN (January 2008). "Mechanism of nuclear calcium signaling by inositol 1,4,5-trisphosphate produced in the ... modification of isoprene units donated from the reactive precursors isopentenyl pyrophosphate and dimethylallyl pyrophosphate.[ ... involved in calcium-mediated activation of protein kinase C;[76] the prostaglandins, which are one type of fatty-acid derived ... "The role of sphingosine-1-phosphate and ceramide-1-phosphate in calcium homeostasis". Current Opinion in Investigational Drugs ...
C55-isoprenyl pyrophosphate. *Cacodyl oxide. *4-Caffeoyl-1,5-quinide. *Calcium benzoate ...
However PKC is only active in the presence of calcium ions, and it is DAG that increases the affinity of PKC for Ca2+ and ... which is broken down to AMP and inorganic pyrophosphate) to give a fatty acyl-adenylate, which then reacts with free coenzyme A ... IP3 is rapidly converted to into derivatives that that do not open calcium ion channels. The prostaglandins are a group of ... IP3 stimulates the release of calcium ions from the smooth endoplasmic reticulum, whereas DAG is a physiological activator of ...
The LD50 is 16.8 mg/kg, but only 9.8 mg/kg if calcium carbonate is added to the bait.[34][35] ... This is important for maintaining calcium levels and promoting bone health and development.[7] As a medication, cholecalciferol ... DRIs for Calcium and Vitamin D Archived 2010-12-24 at the Wayback Machine. ... Jolly SE, Henderson RJ, Frampton C, Eason CT (1995). "Cholecalciferol Toxicity and Its Enhancement by Calcium Carbonate in the ...
PRPSAP2: encoding protein Phosphoribosyl pyrophosphate synthetase-associated protein 2. *QRICH2: encoding protein Glutamine- ... CANT1: Calcium-activated nucleotidase 1 (17q25.3). *BIRC5: Survivin (17q25.3). *CHMP6: Charged multivesicular body protein 6 ( ...
... especially calcium.[78][79][80] Some plant foods can reduce the absorption of minerals and vitamins like calcium, zinc, vitamin ... Raschka L, Daniel H (November 2005). "Mechanisms underlying the effects of inulin-type fructans on calcium absorption in the ... which increase absorption of calcium,[42] magnesium,[43] and iron,[44] resulting from upregulation of mineral-transporting ... and long-chain inulin-type fructans enhances calcium absorption and bone mineralization in young adolescents". Am J Clin Nutr. ...
Thiamine pyrophosphate [30]. Thiamine (B1). None. 2-carbon groups, α cleavage. Bacteria, archaea and eukaryotes ... Clapham DE (2007). "Calcium signaling". Cell. 131 (6): 1047-58. doi:10.1016/j.cell.2007.11.028. PMID 18083096.. ... Calcium is another special case, in that it is required as a component of the human diet, and it is needed for the full ... Calcium is, therefore, a cell signaling molecule, and not usually considered a cofactor of the enzymes it regulates.[16] ...
萜烯和類萜(如類胡蘿蔔素)的生成是由異戊二烯單元的組合和修飾,異戊二烯單元是由活性的前驅體焦磷酸異戊烷(英语:isopentenyl pyrophosphate)及焦磷酸二甲基烯丙酯(英语:dimethylallyl pyrophosphate)提供[ ... Mechanism of nuclear calcium signaling by inositol 1,4,5-trisphosphate produced in the nucleus, nuclear
... (ADP), also known as adenosine pyrophosphate (APP), is an important organic compound in metabolism and is ...
Calcium-sensing receptor. *GABAB (1. *2). *Glutamate receptor (Metabotropic glutamate (1 ...
Inorganic phosphate can be created by the hydrolysis of pyrophosphate, denoted PPi: P. 2O4−. 7 + H2O ⇌ 2 HPO2−. 4. However, ... Calcium hydroxyapatite and calcite precipitates can be found around bacteria in alluvial topsoil.[14] As clay minerals promote ... Phosphate can form many polymeric ions such as pyrophosphate), P. 2O4−. 7, and triphosphate, P. 3O5−. 10. The various ... The pyrophosphates are mostly water-soluble. Aqueous phosphate exists in four forms: *In strongly basic conditions, the ...
This molecule acts in calcium signaling by releasing calcium from intracellular stores.[61] It does this by binding to and ... "The participation of inorganic pyrophosphate in the reversible enzymatic synthesis of diphosphopyridine nucleotide" (PDF). J. ... Guse AH (2004). "Regulation of calcium signaling by the second messenger cyclic adenosine diphosphoribose (cADPR)". Curr. Mol. ... opening a class of calcium channels called ryanodine receptors, which are located in the membranes of organelles, such as the ...
The metabolically active form of thiamine is thiamine pyrophosphate, which plays a major role as a cofactor or coenzyme in ... The enzymes that are dependent on thiamine pyrophosphate are associated with the citric acid cycle (also known as the Krebs ...
Precipitation of crystals of calcium pyrophosphate dihydrate (CPP) in connective tissues may be asymptomatic or may be ... Pathogenesis and etiology of calcium pyrophosphate crystal deposition (CPPD) disease. *Patient education: Calcium pyrophosphate ... Treatment of calcium pyrophosphate crystal deposition (CPPD) disease. Author. Michael A Becker, MD. Michael A Becker, MD ... Calcium Pyrophosphate Deposition Disease. N Engl J Med 2016; 374:2575.. *Zhang W, Doherty M, Bardin T, et al. European League ...
Calcium pyrophosphate dihydrate (CPPD) crystal deposition disease is slightly more prevalent in men. Chondrocalcinosis results ... Calcium deposition is often seen at the triangular fibrocartilage of the wrist. Subchondral sclerosis, joint space narrowing, ...
Learn more about Calcium Pyrophosphate Dihydrate Deposition Disease at Medical City Dallas DefinitionCausesRisk ... Calcium pyrophosphate dihydrate deposition disease (CPPD) is a build up of calcium crystals in the joints. These crystals cause ... It is not known what causes these calcium pyrophosphates to form. Genetics appear to play a role since it may run in families. ... Calcium pyrophosphate deposition (CPPD) (formerly called pseudogout). American College of Rheumatology website. Available at: ...
If you are a society or association member and require assistance with obtaining online access instructions please contact our Journal Customer Services team ...
Calcium Pyrophosphate Arthritis - Etiology, pathophysiology, symptoms, signs, diagnosis & prognosis from the Merck Manuals - ... Calcium Pyrophosphate Arthritis (Calcium Pyrophosphate Dihydrate Crystal Deposition Disease; Acute Calcium Pyrophosphate ... Calcium Pyrophosphate Arthritis (Calcium Pyrophosphate Dihydrate Crystal Deposition Disease, Pyrophosphate Arthropathy, or ... Calcium pyrophosphate arthritis involves intra-articular and/or extra-articular deposition of calcium pyrophosphate dihydrate ( ...
Formation Product of Calcium Pyrophosphate Crystals in Vitro and the Effect of Iron Salts. P. R. Hearn, R. G. G. Russell, J. C. ... Formation Product of Calcium Pyrophosphate Crystals in Vitro and the Effect of Iron Salts ... Formation Product of Calcium Pyrophosphate Crystals in Vitro and the Effect of Iron Salts ... Formation Product of Calcium Pyrophosphate Crystals in Vitro and the Effect of Iron Salts ...
Chondrocalcinosis at the knee, wrist, or symphysis pubis is virtually diagnostic of calcium pyrophosphate dehydrate deposition ...
Chronic calcium pyrophosphate crystal inflammatory arthritis induced by extreme hypomagnesemia in short bowel syndrome. ... Despite the rarity of this condition, it is important to know that hypomagnesaemia may be associated with calcium pyrophosphate ... Chondrocalcinosis, is defined as the deposition of calcium pyrophosphate dihydrate in hyaline or fibrous cartilage [14]. In ... Jones AC, Chuck AJ, Arie EA, Green DJ, Doherty M: Diseases associated with calcium pyrophosphate deposition disease. Semin ...
... also referred to as calcium pyrophosphate deposition disease, or CPDD, is a form of arthritis caused by crystal deposits in ... Psuedogout, also referred to as calcium pyrophosphate deposition disease, or CPDD, is a form of arthritis caused by crystal ...
They define calcium pyrophosphate deposition (CPPD) as an umbrella term for all instances of calcium pyrophosphate crystal ... Calcium Pyrophosphate Deposition: Terminology and Classification An expert panel put together by the European League Against ... Risk factors for calcium pyrophosphate arthropathy are aging, osteoarthritis, previous joint trauma, metabolic diseases (e.g., ... Calcium pyrophosphate dihydrate crystal deposition disease revisited. Radiology. 1996 Jul;200(1):1-9. *Zhang W, Doherty M, ...
a b c d e f g h i j k l m n Rothschild, Bruce M Calcium Pyrophosphate Deposition Disease (rheumatology) at eMedicine ... Calcium pyrophosphate dihydrate (CPPD) crystal deposition disease, also known as pseudogout and pyrophosphate arthropathy, is a ... Calcium pyrophosphate dihydrate crystal deposition disease. From Wikipedia, the free encyclopedia. (Redirected from Calcium ... a b c d Rothschild, Bruce M Calcium Pyrophosphate Deposition Disease (radiology) ...
Calcium pyrophosphate dihydrate (CPPD) arthritis is a joint disease that can cause attacks of arthritis. Like gout, crystals ... Terkeltaub R. Calcium crystal disease: calcium pyrophosphate dihydrate and basic calcium phosphate. In: Firestein GS, Budd RC, ... Calcium pyrophosphate dihydrate deposition disease; CPPD disease; Acute/chronic CPPD arthritis; Pseudogout; Pyrophosphate ... Deposition of calcium pyrophosphate dihydrate (CPPD) causes this form of arthritis. The buildup of this chemical forms crystals ...
Calcium pyrophosphate dihydrate crystal deposition disease (CPPD) occurs when these crystals form deposits in the joint and ... Calcium Pyrophosphate Deposition Disease (CPPD). What is CPPD (Pseudogout)?. Calcium pyrophosphate dihydrate crystal deposition ... In most cases, the cause of calcium pyrophosphate dihydrate crystal formation is unknown, although deposits increase as people ...
... disease is characterized by the accumulation of calcium crystals in the cartilage tissues of the joints. The crystal deposits ... Calcium pyrophosphate deposition (CPDD) disease is characterized by the accumulation of calcium crystals in the cartilage ... Calcium Pyrophosphate Deposition and Joint Problems. News-Medical. https://www.news-medical.net/health/Calcium-Pyrophosphate- ... Calcium Pyrophosphate Deposition and Joint Problems. News-Medical. 27 June 2019. ,https://www.news-medical.net/health/Calcium- ...
... is a metabolic arthropathy caused by the deposition of calcium pyrophosphate dihydrate in and around joints, especially in ... encoded search term (Calcium Pyrophosphate Deposition Disease) and Calcium Pyrophosphate Deposition Disease What to Read Next ... Calcium pyrophosphate deposition disease (CPDD) is a metabolic arthropathy caused by the deposition of calcium pyrophosphate ... Calcium pyrophosphate deposition disease. Appearance of calcium pyrophosphate dihydrate crystals obtained from the knee of a ...
... , CPPD Deposition, Pseudogout. ... Calcium Pyrophosphate Dihydrate Crystal Deposition. Calcium Pyrophosphate Dihydrate Crystal Deposition Aka: Calcium ... presence of calcium salts, especially calcium pyrophosphate, in the cartilaginous structures of one or more joints, accompanied ... Search other sites for Calcium Pyrophosphate Dihydrate Crystal Deposition NLM Pubmed Google Websites Google Images QuackWatch ...
... is a type of arthritis caused by the deposition of calcium pyrophosphate crystals. Clinical Image Atlas : View clinical images ... Calcium pyrophosphate deposition disease (CPDD) is a type of arthritis caused by the deposition of calcium pyrophosphate ... Primary calcium pyrophosphate deposition disease. Calcium pyrophosphate deposition disease (CPDD) is divided into several ... Secondary calcium pyrophosphate deposition disease. The variety of calcium pyrophosphate deposition disease (CPDD) is ...
Pseudogout Like Gout But Caused by Calcium Pyrophosphate Dihydrate. By MC Kelby HERWriter ... Now, what is calcium pyrophosphate dihydrate? CPPD is the collection of salt crystals which form in the joints and its ... The main difference between the two ailments is that pseudogout is caused by calcium pyrophosphate dihydrate and gout is caused ... This Pseudogout Like Gout But Caused by Calcium Pyrophosphate Dihydrate page on EmpowHER Womens Health works best with ...
An update on the epidemiology of calcium pyrophosphate dihydrate crystal deposition disease.. Richette P1, Bardin T, Doherty M. ...
calcium-pyrophosphate-dihydrate-deposition-disease definition: Proper noun 1. (medicine) A medical condition, also called ... calcium-pyrophosphate-dihydrate-deposition-disease. Proper noun *(medicine) A medical condition, also called pseudogout or CPPD ... www.yourdictionary.com/calcium-pyrophosphate-dihydrate-deposition-disease ... "calcium-pyrophosphate-dihydrate-deposition-disease." YourDictionary, n.d. Web. 17 January 2019. ,https://www.yourdictionary.com ...
Radiological Calcium Pyrophosphate Deposition Disease. Eric A. Brandser, M.D.. Peer Review Status: Internally Peer Reviewed ... Calcium pyrophosphate deposition disease, also known as pseudogout, is a very common entity. Radiographically, the presence of ...
Calcium pyrophosphate crystals were identified in the synovial fluid, and calcium pyrophosphate deposition disease was ... Calcium pyrophosphate deposition disease. N Engl J Med. 2016;374(26):2575-2584. doi:10.1056/NEJMra1511117 [CrossRef] [PubMed] ... Recurrent Painful Calcium Pyrophosphate Arthropathy You will receive an email whenever this article is corrected, updated, or ... Deposition of calcium pyrophosphate crystals into joint spaces can lead to severe, chronic arthritic attacks and damage to the ...
The effect of calcium and magnesium ions on calcium pyrophosphate crystal formation in aqueous solutions. J Rheumatol 1981;8: ... Dissolution of calcium pyrophosphate crystals by polyphosphates: an in vitro and ex vivo study. Ann Rheum Dis 2001;60:962-7. ... EULAR recommendations for calcium pyrophosphate crystal associated arthritis. Part I: Terminology and diagnosis. Ann Rheum Dis ... Molecular modeling of inhibition of crystals of calcium pyrophosphate dihydrate by phosphocitrate. J Mol Struct (Theochem) 1998 ...
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China Calcium propionate, China Potassium sorbate, China Sodium Acid Pyrophosphate ... Sodium Acid Pyrophosphate. CAS NO:7758-16-9; MF:Na2H2P2O7. JIANGSU MUPRO IFT CORP. More>>. ... Calcium propionate. CAS NO:4075-81-4; MF:2(C3H6O2)·Ca. JIANGSU MUPRO IFT CORP. More>>. ...
Calcium pyrophosphate crystal deposition disease & related comorbidities. Take Quiz. Gout occurrence and clinical detection. ... Which of the following conditions is commonly caused by calcium pyrophosphate crystal deposition disease (CPDD)? ...
Distinguishing Gouty Arthritis from Calcium Pyrophosphate Disease and Other Arthritides. Christian Löffler, Horst Sattler, Lena ... Distinguishing Gouty Arthritis from Calcium Pyrophosphate Disease and Other Arthritides. Christian Löffler, Horst Sattler, Lena ... Distinguishing Gouty Arthritis from Calcium Pyrophosphate Disease and Other Arthritides Message Subject (Your Name) has ... Distinguishing Gouty Arthritis from Calcium Pyrophosphate Disease and Other Arthritides. Christian Löffler, Horst Sattler, Lena ...
Clinical aspects of calcium pyrophosphate dihydrate crystal deposition. Rheum Dis Clin North Am 1988;14:395-414. ... Ultrasound detection of calcium pyrophosphate dihydrate crystal deposits in menisci: a pilot in vivo and ex vivo study. Ann ... Ultrasound features of calcium pyrophosphate disease of the knee. Hyperechoic spots (white arrows) in the meniscus (A; lateral ... In the last decade, ultrasonography (US) has been found useful in diagnosing gout1 and calcium pyrophosphate disease (CPPD)2. ...
... Common Name(s). Calcium pyrophosphate deposition disease (CPDD), Calcium ... "Calcium pyrophosphate deposition disease (CPDD)" (open studies are recruiting volunteers) and 28 "Calcium pyrophosphate ... Calcium pyrophosphate deposition disease (CPDD) (also known as chondrocalcinosis, pseudogout, or pyrophosphate arthopathy) is a ... The terms "Calcium pyrophosphate deposition disease (CPDD)" returned 0 free, full-text review articles on human participants. ...
Origin: Mineral , Definition: Dicalcium pyrophosphate , INCI function: Abrasive , CAS... ... Cosmetic Analysis has rated the ingredient Calcium Pyrophosphate. ... Calcium Pyrophosphate Rating based on characteristics:. Please login INCI name CALCIUM PYROPHOSPHATE Alternative names No ... Cosmetics containing Calcium Pyrophosphate. The list of cosmetic products below is a selection of the most requested cosmetics ...
Causes and disease mechanisms. Calcium pyrophosphate is widely distributed in the body, and it is unclear why it sometimes ... Calcium pyrophosphate deposition disease. Some patients have a disorder similar to gout without synovial fluid uric acid ... Instead they have intracellular calcium pyrophosphate dihydrate crystals, a condition known as pseudogout. Such crystals also ... Pyrophosphate crystals account for up 50 percent of acute attacks of crystal arthritis. Similar crystals are seen in the ...
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Crystal arthritides - gout and calcium pyrophosphate arthritis. Part 3: Treatment Autoren:. Dr. med. S. Schlee L. C. Bollheimer ... Crystal arthritides - gout and calcium pyrophosphate arthritis. Part 3: Treatment. Zeitschrift:. Zeitschrift für Gerontologie ... Zhang W, Doherty M, Pascual E et al (2011) EULAR recommendations for calcium pyrophosphate deposition. Part II: Management. Ann ...
  • Calcium pyrophosphate dihydrate deposition disease (CPPD) is a build up of calcium crystals in the joints. (medicalcityhospital.com)
  • Calcium pyrophosphate arthritis involves intra-articular and/or extra-articular deposition of calcium pyrophosphate dihydrate (CPPD) crystals. (merckmanuals.com)
  • CPPD crystal deposition (chondrocalcinosis, pyrophosphate arthropathy), whether symptomatic and asymptomatic, becomes more common with age. (merckmanuals.com)
  • Frequent association with other conditions, such as trauma (including surgery), hypomagnesemia , hyperparathyroidism , gout , hemochromatosis , and old age, suggests that calcium pyrophosphate dihydrate (CPPD) crystal deposits are secondary to degenerative or metabolic changes in the affected tissues. (merckmanuals.com)
  • Recent studies indicate that the ankyrin (ANK) protein is a central factor in producing excess extracellular pyrophosphate, which promotes CPPD crystal formation. (merckmanuals.com)
  • ANK protein is a putative transporter of intracellular and microvesicle pyrophosphate to the extracellular location where CPPD crystals form. (merckmanuals.com)
  • It is a crystal deposition of calcium pyrophosphate dehydrate (CPPD) in cartilage (chondrocalcinosis). (med2date.com)
  • Gout & Calcium Pyrophosphate Deposition Disease (CPPD) are caused by excess uric acid and calcium salt respectively, forming crystals in joints and causing inflammation, redness and swelling. (marahnaturalusa.com)
  • Clinical diagnosis revealed no systemic inflammatory disease, but confirmed extreme hypomagnesemia (0.2 mmol/l) after reproducible pathological magnesium resorption tests as causative for chronic calcium pyrophosphate crystal inflammatory arthritis (pseudogout, chondrocalcinosis). (biomedcentral.com)
  • Despite the rarity of this condition, it is important to know that hypomagnesaemia may be associated with calcium pyrophosphate crystal inflammatory arthritis (chondrocalcinosis) and that SBS patients may be prone to develop extreme hypomagnesaemia causing recurrent joint attacks without systemic inflammation. (biomedcentral.com)
  • Manifestations are protean and may be minimal or include intermittent flares of acute arthritis, termed pseudogout or acute calcium pyrophosphate arthritis, and a degenerative arthropathy that is often severe. (merckmanuals.com)
  • Available at: http://www.dynamed.com/topics/dmp~AN~T114067/Calcium-pyrophosphate-dihydrate-deposition-disease. (medicalcityhospital.com)
  • thus, calcium pyrophosphate crystal disease can mimic many other forms of arthritis. (merckmanuals.com)
  • Psuedogout, also referred to as calcium pyrophosphate deposition disease, or CPDD, is a form of arthritis caused by crystal deposits in joints. (reference.com)
  • Support group for people who have Angiomyolipoma and experience Calcium Pyrophosphate Dihydrate Deposition Disease, created by eHealthMe ( http://www.eHealthMe.com ). (ehealth.me)
  • Diagnosis of calcium pyrophosphate arthritis is established by identifying rhomboid- or rod-shaped crystals in synovial fluid that are not birefringent or are weakly positively birefringent on polarized light microscopy. (merckmanuals.com)
  • Protein bound calcium is inaccessible to the cartilage because it can only be delivered through blood vessels, which are nonexistent in the cartilage. (marahnaturalusa.com)
  • Calcium pyrophosphate deposition disease (CPDD) is a metabolic arthropathy caused by the deposition of calcium pyrophosphate dihydrate in and around joints , especially in articular cartilage and fibrocartilage (see the images below). (medscape.com)
  • Carpenter L, Juliano N, Herb R. Recurrent Painful Calcium Pyrophosphate Arthropathy. (jaoa.org)
  • Although the exact mechanism for the development of CPDD remains unknown, increased adenosine triphosphate breakdown with resultant increased inorganic pyrophosphate in the joints results from aging, genetic factors, or both. (medscape.com)
  • EULAR recommendations for calcium pyrophosphate deposition. (bmj.com)
  • European League Against Rheumatism recommendations for calcium pyrophosphate deposition. (springer.com)
  • It is best prepared by ion exchange from sodium pyrophosphate or by treating lead pyrophosphate with hydrogen sulfide. (wikipedia.org)
  • In double acting baking powders, MCP is often combined with the slow acting acid sodium acid pyrophosphate (SAPP). (wikipedia.org)
  • Sodium pyrophosphate enhances iron bioavailability from bouillon cubes fortified with ferric pyrophosphate . (nih.gov)
  • Product name Calcium Chondroitin Sulfate Chondroitin Assay 90%-105% Calcium NLT 6.0% Sodium NMT 0.5% Loss on Drying NMT 10% Heavy Metal NMT 10 PPT in Total What is the chondroitin sulfate calcium ? (phrmg.org)
  • Phase composition of the as-synthesized powder depended on the precursors concentration: At 2.0 M of calcium acetate in the starting solution, poorly crystallized hydroxyapatite was formed, 0.125 M solution of calcium acetate afforded brushite, and the powders synthesized from 0.25-1.0 M calcium acetate solutions were mixtures of the mentioned phases. (mdpi.com)
  • Deposition of calcium pyrophosphate crystals into joint spaces can lead to severe, chronic arthritic attacks and damage to the cartilage. (jaoa.org)
  • Anions, salts, and esters of pyrophosphoric acid are called pyrophosphates. (wikipedia.org)
  • Comparing soluble ferric pyrophosphate to common iron salts and chelates as sources of bioavailable iron in a Caco-2 cell culture model. (nih.gov)
  • This can be recognized grossly as a calcified sheet reflecting over the articular surface and as concretions of calcium pyrophosphate exuded beyond the subchondral articular surface. (medscape.com)
  • Calcium pyrophosphate arthritis is caused by deposition of articular calcium pyrophosphate (CPP) crystals. (bmj.com)
  • The purpose of the study is to evaluate the effects of martial therapy, comparing different formulations, sucrosomal ferric pyrophosphate, SunActive®Fe micronized and ferric gluconate and. (bioportfolio.com)
  • Rice can only be fortified with ferric pyrophosphate (FePP), which is of low bioavailability in human subjects. (bioportfolio.com)
  • We calculated, that given the small amount of ferric pyrophosphate for those finished products and if melamine was present in the finished products, it would be at levels 100 times lower than the limit of the European Commission's guideline. (thefreedictionary.com)
  • Pharmacokinetics of Ferric Pyrophosphate Citrate, a Novel Iron Salt, Administered Intravenously to Healthy Volunteers. (nih.gov)
  • Ferric pyrophosphate citrate as an iron replacement agent for patients receiving hemodialysis. (nih.gov)
  • A Review of Ferric Pyrophosphate Citrate (Triferic) Use in Hemodialysis Patients. (nih.gov)
  • Effects of micronised microencapsulated ferric pyrophosphate supplementation in patients with advanced cancer and iron deficiency: a single-centre cohort pilot study. (nih.gov)
  • Precipitation of crystals of calcium pyrophosphate dihydrate (CPP) in connective tissues may be asymptomatic or may be associated with several clinical syndromes. (uptodate.com)
  • In most cases, the cause of calcium pyrophosphate dihydrate crystal formation is unknown, although deposits increase as people get older. (arthritis.org)
  • The cause of calcium pyrophosphate arthritis is unknown. (merckmanuals.com)
  • To date, there are no effective treatments capable of dissolving calcium deposits. (symptoma.com)
  • In addition, plain radiography can reveal the linear deposition of calcium pyrophosphate. (medscape.com)
  • 252301.4 2 Claims ABSTRACT OF THE DISCLOSURE Alkaline-earth metal pyrophosphate phosphor is activated by lithium plus any of terbium, europium, samarium, terbium plus europium or europium plus samarium, which phosphor efiiciently converts ultraviolet radiation to visible radiation. (google.com)
  • In patients under the age of 60 years, underlying metabolic conditions associated with calcium pyrophosphate deposition, such as hyperparathyroidism or hemochromatosis, should be investigated. (bmj.com)
  • The mechanism of formation of calcium crystals in hypothyroidism can be similar to hyperparathyroidism. (amazonaws.com)
  • Inflammation and other musculoskeletal changes in arthritis may trigger the formation of calcium pyrophosphate crystals. (amazonaws.com)
  • Thus, we investigated mechanisms by which calcium could affect ePP i metabolism, especially its main regulating proteins ANK and PC-1 (plasma cell membrane gly-coprotein-1). (univ-lorraine.fr)
  • Pyrophosphate and diphosphonates in calcium metabolism and their possible role in renal failure. (ox.ac.uk)
  • Subsequent workup showed normal parathyroid hormone, normal calcium and phosphorous levels, and normal magnesium and alkaline phosphatase. (symptoma.com)
  • Al-Kanani T, MacKenzie AF (1991) Sorption and desorption of orthophosphate and pyrophosphate by mineral fractions of soils, goethite and kaolinite. (thefreedictionary.com)