Calcium Metabolism Disorders: Disorders in the processing of calcium in the body: its absorption, transport, storage, and utilization.Lipid Metabolism Disorders: Pathological conditions resulting from abnormal anabolism or catabolism of lipids in the body.Phosphorus Metabolism Disorders: Disorders in the processing of phosphorus in the body: its absorption, transport, storage, and utilization.Metabolic Diseases: Generic term for diseases caused by an abnormal metabolic process. It can be congenital due to inherited enzyme abnormality (METABOLISM, INBORN ERRORS) or acquired due to disease of an endocrine organ or failure of a metabolically important organ such as the liver. (Stedman, 26th ed)Iron Metabolism Disorders: Disorders in the processing of iron in the body: its absorption, transport, storage, and utilization. (From Mosby's Medical, Nursing, & Allied Health Dictionary, 4th ed)Glucose Metabolism Disorders: Pathological conditions in which the BLOOD GLUCOSE cannot be maintained within the normal range, such as in HYPOGLYCEMIA and HYPERGLYCEMIA. Etiology of these disorders varies. Plasma glucose concentration is critical to survival for it is the predominant fuel for the CENTRAL NERVOUS SYSTEM.Calcium, Dietary: Calcium compounds used as food supplements or in food to supply the body with calcium. Dietary calcium is needed during growth for bone development and for maintenance of skeletal integrity later in life to prevent osteoporosis.Calcium: A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.Calcium Isotopes: Stable calcium atoms that have the same atomic number as the element calcium, but differ in atomic weight. Ca-42-44, 46, and 48 are stable calcium isotopes.Hypocalcemia: Reduction of the blood calcium below normal. Manifestations include hyperactive deep tendon reflexes, Chvostek's sign, muscle and abdominal cramps, and carpopedal spasm. (Dorland, 27th ed)Bone and Bones: A specialized CONNECTIVE TISSUE that is the main constituent of the SKELETON. The principle cellular component of bone is comprised of OSTEOBLASTS; OSTEOCYTES; and OSTEOCLASTS, while FIBRILLAR COLLAGENS and hydroxyapatite crystals form the BONE MATRIX.Parathyroid Hormone: A polypeptide hormone (84 amino acid residues) secreted by the PARATHYROID GLANDS which performs the essential role of maintaining intracellular CALCIUM levels in the body. Parathyroid hormone increases intracellular calcium by promoting the release of CALCIUM from BONE, increases the intestinal absorption of calcium, increases the renal tubular reabsorption of calcium, and increases the renal excretion of phosphates.Hypercalcemia: Abnormally high level of calcium in the blood.Phosphorus: A non-metal element that has the atomic symbol P, atomic number 15, and atomic weight 31. It is an essential element that takes part in a broad variety of biochemical reactions.Calcium Signaling: Signal transduction mechanisms whereby calcium mobilization (from outside the cell or from intracellular storage pools) to the cytoplasm is triggered by external stimuli. Calcium signals are often seen to propagate as waves, oscillations, spikes, sparks, or puffs. The calcium acts as an intracellular messenger by activating calcium-responsive proteins.Calcitriol: The physiologically active form of vitamin D. It is formed primarily in the kidney by enzymatic hydroxylation of 25-hydroxycholecalciferol (CALCIFEDIOL). Its production is stimulated by low blood calcium levels and parathyroid hormone. Calcitriol increases intestinal absorption of calcium and phosphorus, and in concert with parathyroid hormone increases bone resorption.Parturient Paresis: A disease of pregnant and lactating cows and ewes leading to generalized paresis and death. The disease, which is characterized by hypocalcemia, occurs at or shortly after parturition in cows and within weeks before or after parturition in ewes.Vitamin D: A vitamin that includes both CHOLECALCIFEROLS and ERGOCALCIFEROLS, which have the common effect of preventing or curing RICKETS in animals. It can also be viewed as a hormone since it can be formed in SKIN by action of ULTRAVIOLET RAYS upon the precursors, 7-dehydrocholesterol and ERGOSTEROL, and acts on VITAMIN D RECEPTORS to regulate CALCIUM in opposition to PARATHYROID HORMONE.Minerals: Native, inorganic or fossilized organic substances having a definite chemical composition and formed by inorganic reactions. They may occur as individual crystals or may be disseminated in some other mineral or rock. (Grant & Hackh's Chemical Dictionary, 5th ed; McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Calcium Radioisotopes: Unstable isotopes of calcium that decay or disintegrate emitting radiation. Ca atoms with atomic weights 39, 41, 45, 47, 49, and 50 are radioactive calcium isotopes.Hyperparathyroidism: A condition of abnormally elevated output of PARATHYROID HORMONE (or PTH) triggering responses that increase blood CALCIUM. It is characterized by HYPERCALCEMIA and BONE RESORPTION, eventually leading to bone diseases. PRIMARY HYPERPARATHYROIDISM is caused by parathyroid HYPERPLASIA or PARATHYROID NEOPLASMS. SECONDARY HYPERPARATHYROIDISM is increased PTH secretion in response to HYPOCALCEMIA, usually caused by chronic KIDNEY DISEASES.Receptors, Calcium-Sensing: A class of G-protein-coupled receptors that react to varying extracellular CALCIUM levels. Calcium-sensing receptors in the PARATHYROID GLANDS play an important role in the maintenance of calcium HOMEOSTASIS by regulating the release of PARATHYROID HORMONE. They differ from INTRACELLULAR CALCIUM-SENSING PROTEINS which sense intracellular calcium levels.Intestinal Absorption: Uptake of substances through the lining of the INTESTINES.Hydroxycholecalciferols: Hydroxy analogs of vitamin D 3; (CHOLECALCIFEROL); including CALCIFEDIOL; CALCITRIOL; and 24,25-DIHYDROXYVITAMIN D 3.Calcium Channels: Voltage-dependent cell membrane glycoproteins selectively permeable to calcium ions. They are categorized as L-, T-, N-, P-, Q-, and R-types based on the activation and inactivation kinetics, ion specificity, and sensitivity to drugs and toxins. The L- and T-types are present throughout the cardiovascular and central nervous systems and the N-, P-, Q-, & R-types are located in neuronal tissue.Sarcoidosis: An idiopathic systemic inflammatory granulomatous disorder comprised of epithelioid and multinucleated giant cells with little necrosis. It usually invades the lungs with fibrosis and may also involve lymph nodes, skin, liver, spleen, eyes, phalangeal bones, and parotid glands.Parathyroid Glands: Two pairs of small oval-shaped glands located in the front and the base of the NECK and adjacent to the two lobes of THYROID GLAND. They secrete PARATHYROID HORMONE that regulates the balance of CALCIUM; PHOSPHORUS; and MAGNESIUM in the body.Osteomalacia: Disorder caused by an interruption of the mineralization of organic bone matrix leading to bone softening, bone pain, and weakness. It is the adult form of rickets resulting from disruption of VITAMIN D; PHOSPHORUS; or CALCIUM homeostasis.Hypoparathyroidism: A condition caused by a deficiency of PARATHYROID HORMONE (or PTH). It is characterized by HYPOCALCEMIA and hyperphosphatemia. Hypocalcemia leads to TETANY. The acquired form is due to removal or injuries to the PARATHYROID GLANDS. The congenital form is due to mutations of genes, such as TBX1; (see DIGEORGE SYNDROME); CASR encoding CALCIUM-SENSING RECEPTOR; or PTH encoding parathyroid hormone.Dihydroxycholecalciferols: Cholecalciferols substituted with two hydroxy groups in any position.Sheltered Workshops: Protective places of employment for disabled persons which provide training and employment on a temporary or permanent basis.Veterinary Medicine: The medical science concerned with the prevention, diagnosis, and treatment of diseases in animals.Education, Veterinary: Use for general articles concerning veterinary medical education.Veterinary Drugs: Drugs used by veterinarians in the treatment of animal diseases. The veterinarian's pharmacological armamentarium is the counterpart of drugs treating human diseases, with dosage and administration adjusted to the size, weight, disease, and idiosyncrasies of the species. In the United States most drugs are subject to federal regulations with special reference to the safety of drugs and residues in edible animal products.Schools, Veterinary: Educational institutions for individuals specializing in the field of veterinary medicine.Pathology, Veterinary: The field of veterinary medicine concerned with the causes of and changes produced in the body by disease.Directories as Topic: Lists of persons or organizations, systematically arranged, usually in alphabetic or classed order, giving address, affiliations, etc., for individuals, and giving address, officers, functions, and similar data for organizations. (ALA Glossary of Library and Information Science, 1983)Insurance, Disability: Insurance designed to compensate persons who lose wages because of illness or injury; insurance providing periodic payments that partially replace lost wages, salary, or other income when the insured is unable to work because of illness, injury, or disease. Individual and group disability insurance are two types of such coverage. (From Facts on File Dictionary of Health Care Management, 1988, p207)Internet: A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.Parathyroid Neoplasms: Tumors or cancer of the PARATHYROID GLANDS.Endocrine System: The system of glands that release their secretions (hormones) directly into the circulatory system. In addition to the ENDOCRINE GLANDS, included are the CHROMAFFIN SYSTEM and the NEUROSECRETORY SYSTEMS.Parathyroid Diseases: Pathological processes of the PARATHYROID GLANDS. They usually manifest as hypersecretion or hyposecretion of PARATHYROID HORMONE that regulates the balance of CALCIUM; PHOSPHORUS; and MAGNESIUM in the body.International Classification of Diseases: A system of categories to which morbid entries are assigned according to established criteria. Included is the entire range of conditions in a manageable number of categories, grouped to facilitate mortality reporting. It is produced by the World Health Organization (From ICD-10, p1). The Clinical Modifications, produced by the UNITED STATES DEPT. OF HEALTH AND HUMAN SERVICES, are larger extensions used for morbidity and general epidemiological purposes, primarily in the U.S.Databases, Factual: Extensive collections, reputedly complete, of facts and data garnered from material of a specialized subject area and made available for analysis and application. The collection can be automated by various contemporary methods for retrieval. The concept should be differentiated from DATABASES, BIBLIOGRAPHIC which is restricted to collections of bibliographic references.Clinical Coding: Process of substituting a symbol or code for a term such as a diagnosis or procedure. (from Slee's Health Care Terms, 3d ed.)Bone Density: The amount of mineral per square centimeter of BONE. This is the definition used in clinical practice. Actual bone density would be expressed in grams per milliliter. It is most frequently measured by X-RAY ABSORPTIOMETRY or TOMOGRAPHY, X RAY COMPUTED. Bone density is an important predictor for OSTEOPOROSIS.Osteocalcin: Vitamin K-dependent calcium-binding protein synthesized by OSTEOBLASTS and found primarily in BONES. Serum osteocalcin measurements provide a noninvasive specific marker of bone metabolism. The protein contains three residues of the amino acid gamma-carboxyglutamic acid (Gla), which, in the presence of CALCIUM, promotes binding to HYDROXYAPATITE and subsequent accumulation in BONE MATRIX.Vitamin K: A lipid cofactor that is required for normal blood clotting. Several forms of vitamin K have been identified: VITAMIN K 1 (phytomenadione) derived from plants, VITAMIN K 2 (menaquinone) from bacteria, and synthetic naphthoquinone provitamins, VITAMIN K 3 (menadione). Vitamin K 3 provitamins, after being alkylated in vivo, exhibit the antifibrinolytic activity of vitamin K. Green leafy vegetables, liver, cheese, butter, and egg yolk are good sources of vitamin K.Vitamin K 1: A family of phylloquinones that contains a ring of 2-methyl-1,4-naphthoquinone and an isoprenoid side chain. Members of this group of vitamin K 1 have only one double bond on the proximal isoprene unit. Rich sources of vitamin K 1 include green plants, algae, and photosynthetic bacteria. Vitamin K1 has antihemorrhagic and prothrombogenic activity.Vitamin K Deficiency: A nutritional condition produced by a deficiency of VITAMIN K in the diet, characterized by an increased tendency to hemorrhage (HEMORRHAGIC DISORDERS). Such bleeding episodes may be particularly severe in newborn infants. (From Cecil Textbook of Medicine, 19th ed, p1182)Calcinosis: Pathologic deposition of calcium salts in tissues.

I alpha-hydroxycholecalciferol: a treatment of renal bone disease. (1/44)

Three patients with chronic renal failure on maintenance haemodialysis have been treated with 1 alpha-hydroxycholecalciferol (1 alpha-OHCC), a synthetic vitamin D analogue. A daily dose of 2 mug by mouth produced a significant increase in both calcium absorption from the gastrointestinal tract and calcium content of bone. Treatment with 1 alpha-OHCC appears to be effective in cases of metabolic bone disease associated with chronic renal failure.  (+info)

Idiopathic external root resorption associated to hypercalciuria. (2/44)

Although external root resorption (ERR) is a physiological process in deciduous dentition, it is very infrequent in permanent dentition - where the phenomenon is related to the existence of inadequate occlusal forces, periodontal pathology and microtraumatisms, etc. However, in many cases root resorption cannot be attributed to any concrete cause; such cases are defined as idiopathic external root resorption (IERR). Epidemiological studies have found that the underlying cause can only be established in 5% of all ERR. The present study describes three cases of IERR with different degrees of involvement and associated to mild calciuria and a history of nephrolithiasis. Hypercalciuria with normal blood calcium levels is usually idiopathic and exhibits a familial trait, with a prevalence of 20-40 cases per 1,000 individuals in adults. A form of hypercalciuria associated to nephrolithiasis with a mutation of the CLCN5 gene has been identified, involving low molecular weight proteinuria - though this mutation has not been uniformly demonstrated in most cases of idiopathic hypercalciuria. The peculiarity of the cases described in the present study is attributable to the coexistence of IERR with normocalcemic hypercalciuria and nephrolithiasis - thus pointing to the need for in-depth evaluation of the possible association of these three clinical situations.  (+info)

Reduced bone mass in children with idiopathic hypercalciuria and in their asymptomatic mothers. (3/44)

BACKGROUND: Patients with nephrolithiasis and idiopathic hypercalciuria (IH) may exhibit reduced bone mineral density (BMD). Most studies measuring BMD in IH patients employing dual-energy X-ray absorptiometry (DEXA) have been performed in adults, and no study has been conducted in North-American children. Optimal bone mineral accretion during childhood and adolescence is critical to the attainment of a healthy adult skeleton. Bone mineral accretion and eventual adult peak bone mass are largely dependent on genetic factors. Hypercalciuria is also frequently linked to genetic determinants. Therefore, we carried out a cross-sectional evaluation of bone mineral metabolism in children with IH, and in their asymptomatic premenopausal mothers. METHODS: Quantitative BMD using DEXA was performed in 21 children with IH and in their asymptomatic mothers. Bone resorption was assessed by measuring the urinary concentrations of pyridinoline and deoxypiridinoline. Simultaneous calcium-modulating hormonal determinations, including serum intact immunoreactive parathyroid hormone and 1,25(OH)(2)D(3), were performed. The expression of interleukin-1alpha (IL-1alpha) by peripheral blood mononuclear cells (PBMCs) was determined by polymerase chain reaction. RESULTS: Reduced BMD values were observed in eight children (38%) and in seven mothers (33%). The children of osteopenic mothers exhibited significantly reduced BMD Z-score values of lumbar spine (P<0.05) when compared with children of mothers with normal BMD. Bone resorption markers were normal in most children with IH. Hypercalciuria was detected in five out of 20 (25%) asymptomatic mothers and it correlated (r=-0.81) to femoral BMD in mothers with osteopenia. The expression of IL-1alpha mRNA by PBMCs from IH children did not differ from controls. CONCLUSIONS: Reduced BMD was detected in a large proportion of children with IH. Hypercalciuria and reduced BMD were uncovered in a substantial number of their otherwise healthy asymptomatic mothers. The diminished BMD in adults with IH may start early in life, could be influenced by genetic factors, and may represent a risk factor for osteoporosis later in life.  (+info)

Epithelial Ca(2+) channel (ECAC1) in autosomal dominant idiopathic hypercalciuria. (4/44)

BACKGROUND: The epithelial Ca(2+) channel (ECaC) exhibits the defining properties for being the gatekeeper in 1,25-dihydroxyvitamin D(3)-regulated Ca(2+) (re)absorption. Its recently cloned human orthologue (ECaC1) could, therefore, represent a crucial molecule in human disorders related to Ca(2+)-wasting such as idiopathic hypercalciuria (IH). METHODS: Fifty-seven members of nine families with IH were investigated. Phenotyping was performed by measurements of urinary Ca(2+) excretion, while other underlying disorders were appropriately excluded. Initially, the recently suggested locus for kidney stone-associated hypercalciuria on chromosome 1q23.3-q24 was investigated. Next, direct mutation analysis of all 15 exons of the ECAC1 gene and 2.9 kb upstream from the start codon was performed. hECaC1, heterologously expressed in human embryonic kidney 293 cells, was characterized by patch-clamp analysis. RESULTS: The mode of inheritance in the studied pedigrees is consistent with an autosomal dominant trait. Haplotype analysis did not implicate a role of the locus on chromosome 1. The coding sequence of the ECAC1 gene was not different between the affected and the non-affected family members. In the 5'-flanking region, three single nucleotide polymorphisms were encountered, but these polymorphisms were observed regardless of the affection status of the screened family members. Patch-clamp analysis of hECaC1 was performed as the putative pore region contains four non-conserved amino acid substitutions compared with the other species. This analysis revealed the distinctive properties of ECaC, including a high Ca(2+) selectivity, inward rectification, and Ca(2+)-dependent inactivation. CONCLUSION: These results do not support a primary role for hECaC1 in IH in nine affected families. Because of the heterogeneity of the disease, however, the involvement of ECaC1 in other subtypes of IH cannot be excluded and needs further investigation. The electrophysiological properties of hECaC1 further substantiate its prime role in Ca(2+) (re)absorption.  (+info)

Urinary calcium excretion in children with vesicoureteral reflux. (5/44)

BACKGROUND: Renal malformations including vesico-ureteral reflux (VUR) are associated with urolithiasis. However, studies on urinary calcium excretion in children with VUR have not been reported. This study was conducted to find out whether children with VUR have a higher prevalence of hypercalciuria and whether their family members are affected by hypercalciuria and/or urolithiasis. METHODS: We studied the prevalence of hypercalciuria and urolithiasis in 46 children (12 males and 34 females) with VUR and in their parents. RESULTS: Three out of 46 children had renal colic and nine out of 46 exhibited calyceal microlithiasis in the renal sonography. According to Stapleton's criteria, we found that 27 out of 46 children (58.6%) had hypercalciuria. These children were significantly shorter than children with normal calciuria and showed lower values of maximal urinary osmolality. We found no differences in urinary calcium excretion values related to the VUR grading, or to the presence or absence of renal scars, or to whether VUR was still unresolved or already resolved at the time of study. Seventeen out of 27 children with hypercalciuria (63%) had one or both parents affected by hypercalciuria, and there was a history of urolithiasis in six first-degree relatives and in four second-degree relatives (37%). Besides, 10 out of 19 children without hypercalciuria (52.6%) had one or both parents affected by hypercalciuria and there was a history of urolithiasis in three first-degree relatives and in three second-degree relatives (31.6%). Among the 27 children whose parents had hypercalciuria, four had both parents affected, 19 had only the mother affected and in four patients only the father was affected. CONCLUSION: Our results showed that the prevalence of hypercalciuria was greater in paediatric patients with VUR than in the general population. Urolithiasis in patients with VUR had a metabolic origin. Hypercalciuria was inherited as an autosomal dominant trait although with a higher probability to be inherited from the mother.  (+info)

Disruption of the caveolin-1 gene impairs renal calcium reabsorption and leads to hypercalciuria and urolithiasis. (6/44)

Using LoxP/Cre technology, we generated a knockout mouse homozygous for a null mutation in exon 2 of Cav1. In male Cav1-/- animals, we observed a dramatic increase in the incidence of urinary calcium stone formation. In 5-month-old male mice, the incidence of early urinary calculi was 67% in Cav1-/- mice compared to 19% in Cav1+/+ animals. Frank stone formation was observed in 13% of Cav1-/- males but was not seen in Cav1+/+ mice. Urine calcium concentration was significantly higher in Cav1-/- male mice compared to Cav1+/+ mice. In Cav1-/- mice, distal convoluted tubule cells were completely devoid of Cav1 and the localization of plasma membrane calcium ATPase was disrupted. Functional studies confirmed that active calcium absorption was significantly reduced in Cav1-/- compared to Cav1+/+ male mice. These results demonstrate that disruption of the Cav1 gene promotes the progressive steps required for urinary calcium stone formation and establish a new mouse model for urinary stone disease.  (+info)

Quantitative trait loci for hypercalciuria in a rat model of kidney stone disease. (7/44)

Hypercalciuria is the most common risk factor for kidney stones and has a recognized familial component. The genetic hypercalciuric stone-forming (GHS) rat is an animal model that closely resembles human idiopathic hypercalciuria, with excessive intestinal calcium absorption, increased bone resorption, and impaired renal calcium reabsorption; overexpression of the vitamin D receptor (VDR) in target tissues; and calcium nephrolithiasis. For identifying genetic loci that contribute to hypercalciuria in the GHS rat, an F2 generation of 156 rats bred from GHS female rats and normocalciuric WKY male rats was studied. The calcium excretion was six- to eightfold higher in the GHS female than in the WKY male progenitors. Selective genotyping of those F2 rats with the highest 30% and lowest 30% rates of calcium excretion was performed, scoring 98 markers with a mean interval of 23 cM across all 20 autosomes and the X chromosome. With the use of strict criteria for significance, significant linkage was found between hypercalciuria and a region of chromosome 1 at D1Rat169 (LOD, 2.91). Suggestive linkage to regions of chromosomes 4, 7, 10, and 14 was found. The proportion of phenotypic variance contributed by the region on chromosome 1, with appropriate adjustments, was estimated to be 7%. Candidate genes encoding the VDR and the calcium-sensing receptor were localized to regions on rat chromosomes 7 and 11, respectively, but the suggestive quantitative trait locus on chromosome 7 was not in the region of the VDR gene locus. Identification of genes that contribute to hypercalciuria in this animal model should prove valuable in understanding idiopathic hypercalciuria and kidney stone disease in humans.  (+info)

Hypercalciuria is a common and important finding in postmenopausal women with osteoporosis. (8/44)

OBJECTIVE AND DESIGN: The prevalence and the effects of hypercalciuria on bone in patients with primary osteoporosis are poorly defined. We therefore retrospectively analyzed the data of 241 otherwise healthy women. They were 45-88 years of age and had been referred for their first visit to our Unit for Metabolic Bone Diseases over a 2-year period because of primary osteoporosis (bone density T-score < -2.5). METHODS: The main parameters of calcium and skeletal metabolism had been analyzed in all subjects. This population was then divided into two groups, according to the presence (HC+) or absence (HC-) of hypercalciuria. RESULTS: Elevated urinary calcium was present in 19% of the subjects. Due to the selection criteria, spinal and femoral bone loss was similar in the two groups. Urinary calcium, phosphate and fractional calcium excretion were higher in hypercalciuric patients. In a logistic regression model, the higher the Tm of phosphate, the lower the risk of hypercalciuria (odds ratio 0.33, confidence interval 0.18-0.62). On the contrary, hypercalciuria was the most important predictor of low bone mass in HC+ (accounting for more than 50% of the variance in spinal bone density). CONCLUSIONS: Hypercalciuria is a common feature in postmenopausal bone loss. Since increased urinary calcium excretion and low bone mass appear to be linked, hypercalciuria seems to be an important determinant of reduced bone density in this setting as well.  (+info)

*Harold E. Harrison and Helen C. Harrison

They were jointly the authors of Disorders of Calcium and Phosphate Metabolism in Childhood and Adolescence, a comprehensive ... Disorders of Calcium and Phosphate Metabolism in Childhood and Adolescence. Saunders. ... and jointly published more than 175 research papers and one textbook on topics including pediatric metabolic disorders, ...

*Metabolic disorder

Calcium metabolism disorders, Acid-base imbalance, Metabolic brain diseases[1]. Diagnostic method. DNA test[2]. ... Metabolic disorders can be present at birth, and many can be identified by routine screening. If a metabolic disorder is not ... Inherited metabolic disorders are one cause of metabolic disorders, and occur when a defective gene causes an enzyme deficiency ... "Metabolic Disorders: MedlinePlus". www.nlm.nih.gov. Retrieved 27 July 2015.. *^ Graef, John W.; Wolfsdorf, Joseph I.; Greenes, ...

*Alkaline phosphatase

"Measurement of skeletal specific alkaline phosphatase in disorders of calcium metabolism in childhood". Monatsschrift ... Some complexities of bacterial regulation and metabolism suggest that other, more subtle, purposes for the enzyme may also play ... it plays an integral role in metabolism within the liver and development within the skeleton. Due to its widespread prevalence ... "The Role of Intestinal Alkaline Phosphatase in Inflammatory Disorders of Gastrointestinal Tract". Mediators of Inflammation. ...

*Osteitis fibrosa cystica

"Association of Level Oo GFR with Bone Disease And Disorders of Calcium And Phosphorus Metabolism". NKF K/DOQI Guidelines. ... PTH causes the release of calcium from the bones into the blood, and the reabsorption of calcium in the kidney. Thus, excess ... The symptoms of the disease are the consequences of both the general softening of the bones and the excess calcium in the blood ... ESRD occurs when the kidneys fail to produce calcitriol, a form of Vitamin D, which assists in the absorption of calcium into ...

*Phosphonate

... s are also increasingly used in medicine to treat disorders associated with bone formation and calcium metabolism. ... "The intermediate enzymes of isoprenoid metabolism as anticancer targets". Anti-cancer agents in medicinal chemistry. 9 (5): 526 ...

*Calcipotriol/betamethasone dipropionate

... is contraindicated in patients with hypersensitivity to either glucocorticoids or vitamin D or disorders in calcium metabolism ... increased blood calcium levels), urticaria, and exacerbation of psoriasis were reported in ...

*Milk fever

"Parturient Paresis in Cows: Disorders of Calcium Metabolism: Merck Veterinary Manual". www.merckvetmanual.com. Retrieved 2015- ... In normal calcium regulation, a decrease in plasma calcium levels causes the parathyroid glands to secrete parathyroid hormone ... Intravenous calcium, though indicated in many cases, is potentially fatal through "heart blockade", or transient high calcium ... Treatment generally involves calcium injection by intravenous, intramuscular or subcutaneous routes. Before calcium injection ...

*Hypercalcaemia

Calcium metabolism Dent's Disease Hypocalcaemia Electrolyte disturbance Disorders of calcium metabolism Minisola, S; Pepe, J; ... glucocorticoids increase urinary calcium excretion and decrease intestinal calcium absorption no effect on calcium level in ... Since calcium blocks sodium channels and inhibits depolarization of nerve and muscle fibers, increased calcium raises the ... Calcipotriene causes a rapid rise in calcium ion levels. Calcium ion levels can remain high for weeks if untreated and lead to ...

*Charles Enrique Dent

His research interests broadened to include the study of clinical disorders of calcium and phosphorus metabolism, vitamin D ... In 1956 he was appointed Professor of Human Metabolism at UCH. In 1954 he was elected a Fellow of the Royal College of ... In 1946-47 he studied in Rochester, New York on a Rockefeller scholarship, initially in the field of amino-acid metabolism. He ... of partition chromatography for the study of biological fluids and developed methods of random testing for metabolic disorders ...

*Metabolic disorder

Calcium metabolism disorders DNA repair-deficiency disorders Glucose metabolism disorders Hyperlactatemia Iron metabolism ... disorders Lipid metabolism disorders Malabsorption syndromes Metabolic syndrome X Inborn error of metabolism Mitochondrial ... Hur, Kyu Yeon; Lee, Myung-Shik (2015-06-01). "Gut Microbiota and Metabolic Disorders". Diabetes & Metabolism Journal. 39 (3): ... "Metabolic disorders". KidsHealth.org. Retrieved 27 July 2015. Metabolism portal medicine portal. ...

*Calcium-sensing receptor

Molecular Genetics and Metabolism. 64 (3): 198-204. doi:10.1006/mgme.1998.2716. PMID 9719629.. ... Nemeth EF, Shoback D (Jun 2013). "Calcimimetic and calcilytic drugs for treating bone and mineral-related disorders". Best ... response to calcium ion. • regulation of calcium ion transport. • fat pad development. • cellular response to vitamin D. • ... The calcium-sensing receptor (CaSR) is a Class C G-protein coupled receptor which senses extracellular levels of calcium ion. ...

*Disorders of calcium metabolism

... occur when the body has too little or too much calcium. The serum level of calcium is closely ... Disorders in calcium metabolism can lead to hypocalcemia, decreased plasma levels of calcium or hypercalcemia, elevated plasma ... and therefore levels of ionized calcium are better measures than a total calcium; however, one can correct a total calcium if ... A normal ionized calcium is 1.12-1.45 mmol/L (4.54-5.61 mg/dL). A normal total calcium is 2.2-2.6 mmol/L (9-10.5 mg/dl). Total ...

*ICD-10 Chapter XVI: Certain conditions originating in the perinatal period

Transitory disorders of carbohydrate metabolism specific to fetus and newborn (P71) Transitory neonatal disorders of calcium ... Other disorders of muscle tone of newborn (P94.9) Disorder of muscle tone of newborn, unspecified (P95) Fetal death of ... Other cardiovascular disorders originating in the perinatal period (P29.9) Cardiovascular disorder originating in the perinatal ... Other transient neonatal disorders of coagulation (P61.8) Other specified perinatal haematological disorders (P61.9) Perinatal ...

*Calcium acetate/magnesium carbonate

... as well as metabolism and nutritional disorders, e.g. hypercalcaemia or hypermagnesaemia. Chronic kidney disease Chronic kidney ... Calcium acetate/magnesium carbonate is a fixed-dose combination drug that contains 110 mg calcium and 60 mg magnesium ions and ... Calcium acetate/magnesium carbonate is taken orally together with the meal. Calcium acetate and magnesium carbonate compounds ... the so-called chronic kidney disease-mineral and bone disorder, CKD-MBD). In addition to dialysis therapy and dietary ...

*D. Sudhaker Rao

His main research interests are the role of vitamin D and calcium nutrition in parathyroid disorders and bone health. He has ... He specializes in bone and mineral metabolism and endocrinology, specifically in hyperparathyroidism, osteomalacia, and bone ... Rao has contributed extensively to the broad field of bone & mineral metabolism. ...

*Porcine stress syndrome

It is an inherited, autosomal recessive disorder due to a defective ryanodine receptor leading to huge calcium influx, muscle ... contracture and increase in metabolism. PSS can manifest itself in the abattoir as the production of Pale, Soft and Exudative ... This disorder is most common in Landrace, Piétrain and crossbreeds of these breeds of pig. The genes may have been favoured in ... This means that the disorder is rare in the developed world these days. Stress at slaughter should be minimised in all cases. ...

*Klotho (biology)

Regulation of calcium and phosphate metabolism by FGF23/Klotho]". Clinical Calcium. 19 (4): 523-8. PMID 19329831. Nabeshima Y ( ... Dec 2000). "Challenge of overcoming aging-related disorders". Journal of Dermatological Science. 24 Suppl 1: S15-21. doi: ... The mechanism of action of klotho is not fully understood, but it changes cellular calcium homeostasis, by both increasing the ... Torres PU, Prié D, Beck L, De Brauwere D, Leroy C, Friedlander G (Jan 2009). "Klotho gene, phosphocalcic metabolism, and ...

*Chronic kidney disease

... currently describes a broader clinical syndrome that develops as a systemic disorder of mineral and bone metabolism due to CKD ... manifested by either one or a combination of: 1) abnormalities of calcium, phosphorus (phosphate), parathyroid hormone, or ... The concept of chronic kidney disease-mineral bone disorder (CKD-MBD) ... vitamin D metabolism; 2) abnormalities in bone turnover, mineralization, volume, linear growth, or strength (renal ...

*Renal osteodystrophy

Lui S, Chu H (1943). "Studies in calcium and phosphorus metabolism with special reference to pathogenesis and effects of ... CKD-MBD is defined as a systemic disorder of mineral and bone metabolism due to CKD manifested by either one or a combination ... It is one measure of the skeletal component of the systemic disorder of chronic kidney disease-mineral and bone disorder (CKD- ... phosphate binders such as calcium carbonate, calcium acetate, sevelamer hydrochloride or carbonate, lanthanum carbonate, ...

*Chief cell

PTH plays an important role in regulating blood calcium levels by raising the amount of calcium in the blood.[7] Parathyroid ... "Clinical Cases in Mineral and Bone Metabolism. 7 (3): 207-240. PMC 3213842.. ... "BMC Endocrine Disorders. 7: 8. doi:10.1186/1472-6823-7-8. PMC 2099428. PMID 17916247.. ... It produces and secretes parathyroid hormone in response to low calcium levels. ...

*Mallinckrodt General Clinical Research Center

Much research on calcium metabolism was done during the 1960s. In the 1970s, Edgar Haber first used antibodies to treat ... Klibanski used rhIGF-1 to treat bone loss among people with anorexia nervosa and other eating disorders. Janet Hall and William ... This treatment is still the most effective for the disorder. Anne Klibanski and Ridgway studied the glycoprotein secretion of ...

*Stanozolol

... gastrointestinal disorders resulting in alterations of normal metabolism; use during pre-operative and postoperative periods in ... Equal or greater consideration should be given to diet, calcium balance, physiotherapy, and good general health promoting ... Because of the presence of its 17α-methyl group, the metabolism of stanozolol is sterically hindered, resulting in it being ... due to a C17α alkylation which allows the hormone to survive first-pass liver metabolism when ingested. It is because of this ...

*Sestamibi parathyroid scintigraphy

Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism. John Wiley and Sons. pp. 168-. ISBN 978-0-9778882-1- ... especially because of the internal biofeedback loop within the body with calcium inherently feeding back to calcium-receptors ... The remaining 3 glands are able to properly regulate serum calcium levels appropriately after the resolution of the ... hypercalcemia, as the calcium receptors lead to stimulation of parathyroid hormone secretion.[citation needed] ...

*Inositol-trisphosphate 3-kinase

Also, because of its role in metabolism, ITP3K is involved in the therapeutic use of inositol when taken for bipolar disorder, ... Calcium serves as a second messenger for various downstream cellular events including glycogen metabolism, muscle contraction, ... This is consistent with the calcium signalling pathway that is modulated by metabolism of inositol, which includes ITP3K. In ... In this way, IP4 may actually serve to prolong the calcium signal by activating the influx of calcium stores from the ...

*Cauliflower

Disorders, pests and diseasesEdit. The most important disorders affecting cauliflower quality are a hollow stem, stunted head ... "Glucosinolate metabolism, functionality and breeding for the improvement of Brassicaceae vegetables". Breed Sci. 64 (1): 48-59 ...
To define the mechanism for the hypercalciuria in spontaneously hypertensive rats (SHR), Ca clearance was evaluated in fasted 23-wk-old SHR and normotensive Wistar Kyoto (WKy) controls. There was no exaggerated calciuria before or after parathyroidectomy. Ca balance was therefore measured in the nonfasted animals, which revealed hyperabsorption in SHR of both sexes with increments 10-fold that of Ca excretion, supporting the primacy of intestinal hyperabsorption. In situ duodenal Ca uptake was also increased in the SHR. Parathyroidectomy did not affect the hyperabsorption. Hypercalcemia (total and ionized) and hypercalciuria in SHR associated with reduced adenosine 3,5-cyclic monophosphate excretion, were abolished by fasting. Correction of hypertension for 6 mo failed to abolish the hypercalciuria. Bone Ca deposits were increased in 1-yr-old SHR. Ten-week-old SHR, in contrast, displayed mild malabsorption. Our data do not support the "renal leak" hypothesis. Instead, the adult SHR is ...
Introduction: A 30-year-old female patient with inherited osteogenesis imperfecta (OI) Type 1 was referred due to hypercalcaemia and suspicion of primary hyperparathyroidism (pHPT). She had serum ca2+ 1.56 mmol/L, serum parathyroid hormone 115 ng/ml (, 70), and pHPT was diagnosed, but no scan uptake. By exploratory neck surgery, all parathyroid glands were hyperplastic and 3 ½ parathyroid + thymus were removed. The HPT was hypothesised to be due to abnormal calcium metabolism from OI (J Endocrinol Invest 1999), although not described previously ...
The answer will be different biochemically speaking for different people, different metabolic types and different imbalances. But as a general rule, bone fractures are related to calcium metabolism inefficiency, specifically as pertains to mineral balance and pH. Good calcium metabolism requires: sufficient calcium levels, sufficient calcium metabolism synergistic factors (primarily magnesium, phosphorus, potassium, vitamin C , E and B6), sufficient sympathetic strength/tone and sufficient pH acidity (an over-alkaline pH will cause calcium to precipitate out of solution and be deposited.). So good calcium metabolism requires sufficient levels of calcium, but beyond the quantitative presence of calcium, the availability of synergistic factors must also be present for proper qualitative calcium utilization. Any one or all of the above factors can be involved. The proper Metabolic Typing interpretation of a hair tissue mineral analysis can be useful in targeting the causal factors. With different ...
This paper reviews the regulation of calcium metabolism in man. The bodys calcium economy is determined by the relationship between the intestinal absorption of calcium, the renal handling of calcium, and by the movements of calcium in and out of the skeleton. These processes are influenced by many factors, the most important of which are parathyroid hormone and the hormones derived from the renal metabolism of vitamin D, notably 1,24-dihydroxyvitamin D3. The role of endogenous calcitonin in man is still controversial, but there are several other hormones which have some influence on calcium metabolism, including thyroid hormone, growth hormone, and the adrenal and gonadal steroids. Clinical disorders of calcium metabolism and their treatment are discussed in terms of the disturbances in normal physiology they represent.
Looking for online definition of absorptive hypercalciuria in the Medical Dictionary? absorptive hypercalciuria explanation free. What is absorptive hypercalciuria? Meaning of absorptive hypercalciuria medical term. What does absorptive hypercalciuria mean?
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1. Because urinary prostaglandin excretion could play a role in idiopathic hypercalciuria (IH), we studied the excretion of prostaglandin E (PGE), calcium and sodium at various urine flows in 21 patients (14 males) with urolithiasis and IH, seven stone formers (five males) with normal calciuria and 20 controls (11 males). Dietary composition was comparable and sodium intake was restricted to 100-120 mmol/day.. 2. Analyses were performed on 30 min urine collections obtained after overnight water deprivation and during water diuresis. Male IH patients had increased levels of urinary PGE at all ranges of urine flow. PGE excretion correlated directly with urine flow in patients and controls, but the slope of this relationship in individual IH male patients was steeper than in controls (P , 0.01). Calciuria correlated directly with urine output in patients with IH but not in controls. Calcium and sodium excretion were directly correlated (P , 0.0001) in patients and controls. There were no ...
Looking for online definition of calcium metabolism in the Medical Dictionary? calcium metabolism explanation free. What is calcium metabolism? Meaning of calcium metabolism medical term. What does calcium metabolism mean?
The majority of patients with sarcoidosis in this large series have had a number of biochemical investigations performed. Abnormal calcium metabolism was demonstrated in 40% of the patients but permanent renal damage due to nephrocalcinosis as a result of persistent derangement of calcium metabolism was rare. Raised immunoglobulin levels were seen. Half the white and two-thirds of the West Indian patients had elevated IgG levels. Abnormal immunoglobulin levels carried no obvious diagnostic or prognostic significance. Raised alkaline phosphatase levels reflected space-occupying hepatic granulomas and occurred in 23% of patients. Serum angiotensin converting enzyme (SACE) was elevated in half the patients. The highest SACE activity was found in patients with severe parenchymal lung infiltration due to sarcoidosis, and the lowest levels in those with inactive disease or after successful management with steroid drugs. SACE levels were not significantly elevated in four other granulomatous ...
This report examines the Bone and Mineral Metabolism Disorders Treatment market standing and opportunity of global plus major regions, from plans of manufacturers, regions, product types and end industries; this report investigates the best manufacturers in global and major regions and splits the Bone and Mineral Metabolism Disorders Treatment market by product type and applications/end…
Findings: Among 778 children, 195 (25.1%) had UCa/UCr ratio more than 0.21 mg/mg, but from these 195 children only 128 children delivered 24 hours urine samples. Among these 128 children for whom 24 hours urine calcium measurements were done 28 children excreted more than 4mg/kg/day calcium without hypercalcemia or any other known causes of hypercalciuria and we defined them as having idiopathic hypercalciuria. If all 195 suspicious cases of IH had delivered 24-hrs urine samples we would have 42 cases of IH ...
A new method, based on computer-assisted kinetic analysis of 45Ca efflux data, was used to measure calcium contents and fluxes for extracellular and intracellular compartments in intact segments of rabbit aorta. After a 1-hour loading period, efflux data were collected for 8 hours using a flow-through tissue chamber. These long-term effluxes were necessary because information on intracellular calcium metabolism was concentrated in the slow components of the efflux curves while earlier components appeared to be dominated by washout of extracellular calcium. Intracellular compartments were identified as those whose calcium contents were altered by 10 microM phenylephrine. This method complements previous approaches by providing simultaneous estimates of compartmental calcium contents and fluxes without requiring the assumption of isotopic equilibrium and without recourse to standard wash techniques for removal of extracellular calcium. In normal, calcium-containing, bicarbonate-buffered ...
A group of scientists studying calcium metabolism in laboratory rats discovered that removing the rats parathyroid glands resulted in the rats having substantially lower than ...
Free, official coding info for 2018 ICD-10-CM E83.50 - includes detailed rules, notes, synonyms, ICD-9-CM conversion, index and annotation crosswalks, DRG grouping and more.
Learn about the causes, symptoms, diagnosis & treatment of Inherited Disorders of Metabolism from the Professional Version of the Merck Manuals.
Sigma-Aldrich offers abstracts and full-text articles by [Tao Wu, Anqi Guo, Qingyu Shu, Yangjian Qi, Ying Kong, Zhiping Sun, Shumin Sun, Zhengwei Fu].
A real bathtub has two drains. The one at the bottom is the one you can open or close. The other one, up near the top, is to keep the tub from flooding your bathroom if someone inattentive leaves the faucets open. This second drain is about the level where most people would want their bath water. It has to be. To keep the water line above the open waste overflow drain would require both faucets be wide open.. Fill up a bathtub part way, with the bottom drain and both the hot and cold faucets partly open. Be careful to bring the water level to below the upper drain as we want it to be out of the picture. Wait until the water level is steady.. Call the cold tap inflow from diet, and the hot tap inflow from bone. The drain is the kidneys, the flow through the drain is the urine calcium excretion. The height of the water in the tub is the blood calcium concentration. Because the water level is steady the flow out of the drain equals the sum of water coming in from the hot and cold water taps ...
Bioforce A. Vogel Calcium Absorption 400 Tablets Exclusive formula featuring stinging nettle and silica in homeopathic form, combined with tissue salts, which work together to help the body absorb needed minerals. Calcarea carbonica (calcium carbonate) 4X Calcium carbonate is obtained from pulverized oyster shells. In homeopathy, oyster calcium is known as a stimulant of the periosteum (a membrane covering the bone and involved in bone regeneration and growth). It is also useful for mental and physical exhaustion, calcium metabolism disorders and delayed dentition. Use: Adults Place 2 tablets under the tongue 3 times daily, 15 minutes before eating Allow to slowly dissolve in the mouth. If tablets are slow to dissolve, chew and continue to absorb sublingually. Children: 2-6 years of age: half the adult dose. Over 6 years of age: give adult dose. Duration of treatment An improvement in symptoms follows long-term intake of the tablets. Treatment should be continued for six months. Each
Calcium plays an important role in several body functions, including muscle contractions, enzyme function, and nerve conduction. Calcium is stored in the bones.. Disorders affecting calcium metabolism require clinical care by a physician or other health care professional. Listed in the directory below are some of the disorders that affect calcium metabolism, for which we have provided a brief overview.. If you cannot find the information in which you are interested, please visit the Diabetes & Other Endocrine and Metabolic Disorders Online Resources page in this website for an Internet address that may contain additional information on that topic.. ...
Metabolism disorders have to do with the way your body turns food into energy. Our endocrinologists at WTMF in Fremont provide advanced testing & treatment.
In this agreeable volume the 10 chapters jostle each other, and produce silent cadences that may be as valuable as the mass of information they contain. Taken one by one, the contributions are standard professional fare, of good to excellent quality. Coburn, Massry, and colleagues, in two chapters, review intestinal absorption and renal handling of calcium, magnesium and phosphorus in chronic renal insufficiency. They are expert.. The editor provides a useful compendium of mineral disturbances in uremia. That lacks the laconic terseness of the other essays, perhaps because most of it reviews work outside of his own personal research area; ...
Much attention in the last few years has been devoted to the clarification of the possible role of taurine in thermoregulation. One of the most striking and consistent effects of central (icv)...
You can develop a metabolic disorder if certain organs - for instance, the pancreas or the liver - stop functioning properly. These kinds of disorders can be a result of genetics, a deficiency in a certain hormone or enzyme, consuming too much of certain foods, or a number of other factors.. There are hundreds of genetic metabolic disorders caused by mutations of single genes. These mutations can be passed down through generations of families. According to the National Institutes of Health (NIH), certain racial or ethnic groups are more likely to pass on mutated genes for particular inborn disorders. The most common of these are:. ...
During a search for cause of my health conditions, I came across this website that shows disorders related to amino acid metabolism. Ive stripped out...
Pediatric metabolic disorders happen when a childs body is not appropriately processing nutrients. Our providers will treat your childs metabolic disorder.
INTRODUCTION: The incidence of pediatric nephrolithiasis (kidney stones) has been increasing over the past several years. While environmental factors, such as poor fluid intake, high-salt diet, and obesity, can play a role, underlying metabolic factors account for at least one-third of cases of nephrolithiasis. Nephrolithiasis and related disorders, such as nephrocalcinosis and hypercalciuria, can lead to long-term kidney problems, including renal scarring, acute and chronic kidney disease, decreased renal function, or end-stage renal disease. The best treatment is prevention and is best guided by knowing the underlying cause. The majority of kidney stones are primarily comprised of calcium, and abnormal calcium metabolism and regulation can lead to nephrolithiasis, nephrocalcinosis, and hypercalciuria. Vitamin D is an important factor in calcium regulation in the body. The physiologically active form of vitamin D is 1α,25-dihydroxyvitamin D (1,25(OH)2D), which increases serum calcium by ...
My article on idiopathic hypercalciuria reviews the complex evolution of thought concerning pure absorptive vs. renal mechanisms and eventually comes to rest on a not unexpected consensus: High absorption and reduced renal calcium conservation both seem present. As a result people with IH will not in general - though there may be specific exceptions - tolerate low calcium diets without incurring risk of bone mineral loss. Until recently, in the absence of compelling evidence for a wide spread renal mechanism for hypercalciuria, low calcium diet was a common means for reducing calcium stone recurrence.. It is against that background that the Borghi trial needs to be analysed. The trial set out to compare …the traditional low calcium diet with that of a diet containing a normal amount of calcium but reduced amounts of animal protein and salt in terms of new calcium stone formation in patients with IH - unfortunately only men. One stated reason for the trial was data from Curhan showing ...
The effects of several lactones were studied in a microsomal fraction of dog myocardium thought to be sarcoplasmic reticulum. The lactones increased the steady-state accumulation and turnover of calcium only in the presence of ATP, and augmented the calcium-stimulated ATPase activity. When the effective concentrations of the lactones were exceeded, there were no further alterations in calcium accumulation or turnover. A correlation between the capacity of these lactones to increase calcium accumulation and turnover and their relative cardiotonic activity, as reported in the literature, was noted. The potency of the lactones in relation to calcium metabolism in the microsomes is influenced by ring saturation, position of the double bond, and presence of a steroid ring system to the lactone moiety.. ...
... On-line free medical diagnosis assistant. Ranked list of possible diseases from either several symptoms or a full patient history. A similarity measure between symptoms and diseases is provided.
Research of hydroxycitric acid use feasibility for the carbohydrate metabolism disorders correction due to experimental insulin resistance in rats
Familial Hypomagnesaemia with Hypercalciuria and Nephro-calcinosis (FHHN) is a rare disorder of calcium and magnesium paracellular transportation at TAL level
We offer clinical cancer updates, treatment guidance, and research news to the oncology nursing community. Visit us often for drug therapy testing results, patient care information and more. Download our FREE app today.
Neuroscientists have long suspected that abnormal calcium signaling and accumulation of misfolded proteins cause an intracellular membrane-bound organelle called the endoplasmic reticulum (ER) to trigger the abnormal death ...
Mutations of these genes account for the highly genetic hetero-geneous disorder represented by Bartters syndrome. This dis-ease consists of a set of renal
Coe, FL, Evan, A, Worcester, E. "Pathophysiology-based treatment of idiopathic calcium kidney stones". Clin J Am Soc Nephrol. vol. 6. 2011. pp. 2083-2092. Worcester, EM, Coe, FL. "Calcium kidney stones". N Engl J Med. vol. 363. 2010. pp. 954-963. Borghi, L, Schianchi, T, Meschi, T, Guerra, A, Allegri, F, Maggiore, U, Novarini, A. "Comparison of two diets for the prevention of recurrent stones in idiopathic hypercalciuria". N Engl J Med. vol. 346. 2002. pp. 77-84. Stamatelou, KK, Francis, ME, Jones, CA, Nyberg, LM, Curhan, GC. "Time trends in reported prevalence of kidney stones in the United States". Kidney Int. vol. 63. 2003. pp. 1817-1823. Rule, AD, Bergstralh, EJ, Melton, LJ, Li, X, Weaver, AL, Lieske, JC. "Kidney stones and the risk for chronic kidney disease". Clin J Am Soc Nephrol. vol. 4. 2009. pp. 804-8011. Taylor, EN, Stampfer, MJ, Curhan, GC. "Obesity, weight gain, and the risk of kidney stones". JAMA. vol. 293. 2005. pp. 455-462. Heilberg, IP, Weisinger, JR. "Bone disease in ...
Parathyroid Gland & Calcium Metabolism. Munir Gharaibeh, MD, PhD, MHPE Faculty of Medicine The Jordan University April 2014. Calcium. Normal Ca++ blood level is around 9-10 mg/dl Ca ++ excess cause weakness Ca++ causes tetany . 3 factors are involved in Ca++ blood level: PTH Slideshow 3356810 by roland
Merck & Co., Inc., Kenilworth, NJ, USA is a global healthcare leader working to help the world be well. From developing new therapies that treat and prevent disease to helping people in need, we are committed to improving health and well-being around the world. The Merck Veterinary Manual was first published in 1955 as a service to the community. The legacy of this great resource continues as the Merck Veterinary Manual in the US and Canada and the MSD Manual outside of North America.. ...
Since the lipid nephrotoxicity hypothesis was proposed in 1982, increasing evidence has supported the hypothesis that lipid abnormalities contributed to the progression of glomerulosclerosis. In this...
Cancer Therapy Advisor provides nephrology and hypertension specialist with the latest information to correctly diagnose nephrology and hypertension conditions, recommend procedures and guides. Visit often for updates and new information.
Phosphorus-Inorganic Serum test is required when symptoms of abnormal calcium like fatigue, muscle weakness, bone pain are visible or in gastrointestinal or kidney disorder.
Alfacip is used to treat osteoporosis and conditions with impairments of calcium metabolism such as bone loss due to age. 0.5/mcg 0.25/mg.
i Considerations for calcium metabolism -Prelay diets and prelay management are designed to allow the bird the opportunity to establish adequate medullary bone
Disc-Flex is a powerful, wide reaching complex taking aim at the role of proteoglycans, age-related advanced glycation end product activity, tissue calcium metabolism, immune response and the natural inflammatory processes on spinal disc health.
Background and aims: Alterations in carbohydrate metabolism are frequently observed in cirrhosis; to determine the frequency of diabetes mellitus and impaired glucose tolerance in Tunisian cirrhotic patients and identify risk factors. Patients and methods: Cross-sectional study; fasting plasma glucose levels were measured in consecutive patients with cirrhosis. Oral glucose tolerance test was performed if fasting plasma glucose level was normal. Glucose metabolism disorders were then classified as: impaired glucose tolerance and diabetes mellitus. Cirrhotics with glucose metabolism disorder were compared to those without. Results: Seventy-seven patients with cirrhosis were included: 68.8% were diagnosed as having glucose metabolism disorder; diabetes in 42.8% and impaired glucose tolerance in 26%. The tests were able to identify 60.4% of glucose metabolism disorders. Univariate analysis disclosed a higher proportion of female gender (p = 0.04) and more frequent familial history of diabetes mellitus (p =
The demonstration that the rare disorder, familial hypocalciuric hypercalcemia (FHH), was caused by inactivating mutations in the gene for the calcium-sensing receptor (CaSR, sometimes referred to as CaR) had two major consequences; it explained the
TY - JOUR. T1 - Exaggerated cyclic AMP response to parathyroid hormone in familial hypocalciuric hypercalcemia. AU - Marx, S. J.. AU - Spiegel, Allen M.. AU - Sharp, M.. PY - 1979. Y1 - 1979. UR - http://www.scopus.com/inward/record.url?scp=0018428626&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0018428626&partnerID=8YFLogxK. M3 - Article. AN - SCOPUS:0018428626. VL - 27. JO - Journal of Investigative Medicine. JF - Journal of Investigative Medicine. SN - 1081-5589. IS - 2. ER - ...
TY - JOUR. T1 - Sickle red cell calcium metabolism. T2 - Studies on Ca2+‐Mg2+ATPase and ca‐binding properties of sickle red cell membranes. AU - Litosch, Irene. AU - Lee, Kwang Soo. PY - 1980/6. Y1 - 1980/6. N2 - Sickle (Hb SS) red cells, preloaded with 45Ca by reversal of hemolysis, exhibit an incomplete 45Ca extrusion, retaining approximately four times more 45Ca than normal cells. Studies indicated that neither the reduction in Hb SS cell Ca2+-Mg2+ ATPase activity (84% of normal) nor the activation of Ca2+ -Mg2+ ATPase by calmodulin was sufficiently different from normal cells to attribute a major role to the calcium pump in 45Ca retention. These results suggested that 45Ca retention may reflect an alteration in the calcium-binding properties of Hb SS cell membranes. Low-affinity calcium- binding (freely dissociable) was similar in normal and Hb SS cell membranes. However, the total calcium bound with high-affinity (tightly bound) was four-to-five times greater in Hb SS cell membranes ...
Several studies have suggested that morbid obesity is associated with vitamin D deficiency and elevated parathyroid hormone (PTH). Studies have also suggested that there is an increase in vitamin D de
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Freshly voided urine should be measured for bicarbonate and pH. A 24-hour urine collection also should be collected, for measurement of calcium, phosphorus, sodium, and magnesium.
The thesis is drafted up on 120 pages, being classically divided in compartments: introduction, 4 chapters, conclusions and practical recommendations, bibliography from 181 sources, 21 annexes, includes 27 tables and 19 figures. The got results are published in 25 scientific works, including one guideline on 88 pages. Goal of research: Elaboration of a complex program of individual therapeutic and social management of children that are suffering from Phenylalanine (Phe) metabolism disorders, including Phenylketonuria (PKU). Objectives of research: The investigation of free amino acids spectrum in blood and urine as well as of chemical parameters to children with PKU and with Phenylalaninuria till and after application of metabolic correction measures; specification and completion of diagnosis criteria of Phenylalaninuria as persistent disorders of Phe metabolism; argumentation of drug treatment necessity for metabolism correction in the completion of specific dietetic regime; quantification of ...
In recent years there has been an increase in the diagnosis of Metabolic Bone disease in hedgehogs and it is a life-threatening syndrome. While the
The single tyrosine residue in both pig and cow intestinal Ca2+-binding proteins fluoresces at 303 nm although the crystal structure of the cow protein shows a hydrogen bond between the hydroxy group of the tyrosine and glutamate-38 [Szebenyi & Moffat (1986) J. Biol. Chem. 261, 8761-8777]. The latter interaction suggests that tyrosinate fluorescence should dominate the emission spectra of these proteins. A fluorescence difference spectrum, produced by subtracting the spectrum of free tyrosine from the spectrum of the protein, gives a peak at 334 nm due to ionized tyrosine. That this component of the emission spectrum is not due to a tryptophan-containing contaminant is shown by its elimination when the protein is denatured by guanidine and when glutamate-38 is protonated. We conclude that, in solution, the tyrosine residue in this protein interacts occasionally with glutamate-38 but that a permanent hydrogen bond is not formed. ...
More than 20 mutations in the CYP24A1 gene have been found to cause a type of idiopathic infantile hypercalcemia called infantile hypercalcemia 1, which is characterized by high levels of calcium in the blood (hypercalcemia) and urine (hypercalciuria) and deposits of calcium in the kidneys (nephrocalcinosis). The hypercalcemia typically causes vomiting, poor feeding, and an inability to grow and gain weight at the expected rate (failure to thrive) in infancy, although some affected individuals do not develop signs and symptoms of the condition until adulthood. Features in affected adults, whether they had symptoms in infancy or not, typically include hypercalciuria, nephrocalcinosis, and kidney stones (nephrolithiasis), although they may not cause any obvious health problems.. The CYP24A1 gene mutations that cause infantile hypercalcemia 1 reduce or eliminate the activity of the 24-hydroxylase enzyme. A shortage of this enzymes function impairs the breakdown of calcitriol. The resulting excess ...
used to tonify the liver, kidney, spleen-stomach, invigorate qi, detox and purify bodys internal system, increase the immune response, improve health and appearance for metabolism disorder, endocrine disorders, and skin problems.
TRPV6 / ECAC2, 0.1 ml. FUNCTION: Calcium selective cation channel probably involved in Ca(2+) uptake in various tissues, including Ca(2+) reabsorption in intestine.
White blood cell (WBC) count has been associated with diabetic risk, but whether the correlation is independent of other risk factors has hardly been studied. Moreover, very few such studies with large sample sizes have been conducted in Chinese. Therefore, we investigated the relationship between WBC count and glucose metabolism in china. We also examined the relevant variables of WBC count. A total of 9,697 subjects (mean age, 58.0 ± 9.1 years) were recruited. The subjects were classified into four groups, including subjects with normal glucose tolerance, isolated impaired fasting glucose, impaired glucose tolerance and type 2 diabetes mellitus (T2DM). We found that WBC count increased as glucose metabolism disorders exacerbated. WBC count was also positively correlated with waist hip ratio, body mass index, smoking, triglycerides, glycosylated haemoglobin A1c (HbA1c) and 2-h postprandial glucose. In addition, high density lipoprotein and the female gender were inversely correlated with WBC count. In
ASBMR (2008) Chapter 42. Genetics of Osteoporosis, in Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470623992.ch42 ...
The Metabolic Bone Diseases Clinic at Tufts Medical Center in Boston provides care to manage increased risk for fragility fractures due to bone diseases, like osteoporosis.
The calcium-sensing receptor is a multimodal, multimetabolic sensor that mediates the feedback-dependent control of whole body calcium metabolism. Remarkably, in addition to its role in Ca(2+)(o) (extracellular Ca(2+)) sensing, the CaR (Ca(2+)-sensing receptor) also responds to L-amino acids. L-amino acids appear to activate, predominantly, a signalling pathway coupled with intracellular Ca(2+) mobilization, require a threshold concentration of Ca(2+)(o) for efficacy and sensitize the receptor to activation by Ca(2+)(o). Here, we review the evidence that the CaR, like other closely related members of the class 3 GPCR (G-protein-coupled receptor) family including GPRC6A, is a broad-spectrum amino acid-sensing receptor, consider the nature of the signalling response to amino acids and discuss its physiological significance.
A turtle shell is made of two parts: the plastron and carapace. Both are covered with scutes. Retained scutes (dysecdysis), metabolic bone disease, and trauma are common diseases of the shell.
Dehydrated airway surfaces resulting from sodium hyperabsorption and lack of chloride secretion are critical to the pathology that leads to the morbidity and mortality from Cystic Fibrosis (CF) lung disease. Previously published work in CF cell lines has demonstrated that by increasing cGMP and restoring inhibition of ENaC, sodium hyperabsorption may be reversed following administration of a phosphodiesterase inhibitor (PDEi,) such as sildenafil. Additionally it has been shown in CF cell lines and animal models, that phosphodiesterase inhibitors/analogues can enhance chloride secretion and/or correct surface localization of ΔF508 CFTR. The goal of this project is to translate the results of this work from the laboratory into a clinical trial in patients with CF using an FDA-approved therapy. The Specific Aims of this project are to: 1) Evaluate the effect of systemically administered phosphodiesterase inhibitors on ion transport in CF by measurement of Na+ and Cl- conductance by NPD and Na+ and ...
Sixty mutations of claudin 16 coding gene have been reported in familial hypomagnesemia with hypercalciuria and nephrocalcinosis (FHHNC) patients. Recent investigations revealed that a highly conserved glycine-leucine-tryptophan (115G-L-W117) motif in the first extracellular segment (ESC1) of claudin 16 might be essential for stabilization of the appropriately folded ECS1 structure and conservation of normal claudin 16 function. However, neither missense nor nonsense mutation has ever been described in this motif. Our study aimed at identifying mutations in a Chinese patient with FHHNC and exploring the association between genotype and phenotype. A 33-year-old female presented with 4 years history of recurrent acute pyelonephritis without other notable past medical history. Her healthy parents, who aged 56 and 53 respectively, were second cousins, and her only sibling died from renal failure without definite cause at age 25. Renal ultrasound imaging demonstrated atrophic kidneys and bilateral
RENAL CALICULUS /UROLITHIASIS/KIDNEY STONES / URINARY STONES. When solids and particulate metabolites or salts starts depositing at any level of urinary collecting system it forms renal stones or urolithiasis. Urolithiasis is more common in males than in females. Increased concentration in urine, of the constituents of stones is associated with stone formation.. 1) Calcium Oxalate/Phosphate Stones comprises 75% of every stones.. Its observed that almost 50 % of cases of Calcium Stones that have idiopathic hypercalciuria and doesnt have hypercalcemia.. 10 % of cases calcium stone cases have both hypercalcemia and hypercalciurea. 5% have Enteric(4.5%) or Primary (0.5%) hyperoxaluria. 20% have hyperuricosuria. 15-20% have unknown metabolic anomaly. 2) Struvite Stones (Magnesium, Ammonia, Calcium, Phosphate) usually due to renal infections comprises off 10-15% of all stones.. 3) Uric Acid Stones comprises 6% of all stobe cases 50% of which are associated with hyperuricosuria and/or hyperuricemia ...
RENAL CALICULUS /UROLITHIASIS/KIDNEY STONES / URINARY STONES. When solids and particulate metabolites or salts starts depositing at any level of urinary collecting system it forms renal stones or urolithiasis. Urolithiasis is more common in males than in females. Increased concentration in urine, of the constituents of stones is associated with stone formation.. 1) Calcium Oxalate/Phosphate Stones comprises 75% of every stones.. Its observed that almost 50 % of cases of Calcium Stones that have idiopathic hypercalciuria and doesnt have hypercalcemia.. 10 % of cases calcium stone cases have both hypercalcemia and hypercalciurea. 5% have Enteric(4.5%) or Primary (0.5%) hyperoxaluria. 20% have hyperuricosuria. 15-20% have unknown metabolic anomaly. 2) Struvite Stones (Magnesium, Ammonia, Calcium, Phosphate) usually due to renal infections comprises off 10-15% of all stones.. 3) Uric Acid Stones comprises 6% of all stobe cases 50% of which are associated with hyperuricosuria and/or hyperuricemia ...
Biology Assignment Help, Disorder of parathyroid function, Disorder of Parathyroid Function: The disorders of parathyroid function may either lead to increased production or decreased production of parathormone. Hypoparathyroidism There are two classic forms of hypoparathyroidism which may o
Bone disease - Metabolic bone disease: The normal function of bone requires an adequate supply of amino acids (the building blocks for proteins) for the synthesis of collagen, the chief component of the organic matrix; of calcium and phosphate for mineralization of the organic matrix; and of other organic compounds and mineral elements. Also, growth, repair, and remodeling of the bone tissue require a precisely regulated supply of hormones, vitamins, and enzymes. Skeletal disease, when it is due to inadequacies in the supply or action of the above essentials, associated with abnormalities outside the skeleton, is termed metabolic; in such cases the entire skeleton is affected.
Familial hypocalciuric hypercalcemia (HHC) is a heritable disorder of mineral homeostasis that is transmitted as an autosomal dominant trait with a high degree of penetrance. HHC is characterized biochemically by lifelong elevation of serum calcium concentrations and is associated with inappropriately low urinary calcium excretion and a normal or mildly elevated circulating parathyroid hormone (PTH; {168450}) level. Hypermagnesemia is typically present. Individuals with HHC are usually asymptomatic and the disorder is considered benign. However, chondrocalcinosis and pancreatitis occur in some adults (summary by {17:Hannan et al., 2010 ...
Findings also supportive of an ethnic difference in NKCC2 activity took place during the recovery from furosemide. After furosemide administration, concentrations of Ca and Mg declined in all of the groups to the same level. This was followed by a much slower restoration of their concentrations in blacks than in whites (Figure 5). A more rapid restoration of NKCC2 function in blacks could explain these ethnic differences. Although changes in urinary Ca and Mg excretion were used as markers of TAL reabsorptive activity, we cannot exclude a significant influence on their disposition by DCT, because both sites act to conserve Ca and Mg. Recent studies of mice deficient in TRPV5 in DCT revealed its importance as a mediator of Ca uptake,32 and conceivably there are differences in TRPV5 expression or level of activity that contributes to the ethnic difference in Ca excretion. Transport of Ca in DCT might also be affected by furosemide-induced increases in Ca excretion, as was shown in a mouse model ...
A 53-year-old male presented with recurrent calcium oxalate kidney stones as a first sign of underlying acromegaly, which vanished when his acromegaly was controlled. The exact mechanism behind hypercalciuria and urolithiasis in acromegaly is not yet clear. By discussing this case, a short overview of the pathophysiology of hypercalciuria in acromegaly and practical insights are given. ...
A 53-year-old male presented with recurrent calcium oxalate kidney stones as a first sign of underlying acromegaly, which vanished when his acromegaly was controlled. The exact mechanism behind hypercalciuria and urolithiasis in acromegaly is not yet clear. By discussing this case, a short overview of the pathophysiology of hypercalciuria in acromegaly and practical insights are given. ...
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The Relationship between Serum Osteocalcin Concentration and Glucose Metabolism in Patients with Type 2 Diabetes MellitusThe Relationship between Serum Osteocalcin Concentration and Glucose Metabolism in Patients with Type 2 Diabetes Mellitus

... total osteocalcin and undercarboxylated osteocalcin are closely related to the exacerbation of glucose metabolism disorder but ... The relationship between osteocalcin and parameters of glucose metabolism was also analyzed. We found that the total ... Osteocalcin concentrations were compared between groups of different levels of HbA1c, and parameters of glucose metabolism were ... To study the correlations between serum osteocalcin and glucose metabolism in patients with type 2 diabetes, 66 cases were ...
more infohttps://new.hindawi.com/journals/ije/2013/842598/

Disorders affecting calcium metabolism | Childrens Hospital of WisconsinDisorders affecting calcium metabolism | Children's Hospital of Wisconsin

Disorders affecting calcium metabolism. Calcium plays an important role in several body functions, including muscle ... Disorders affecting calcium metabolism require clinical care by a physician or other healthcare professional. Listed in the ... directory below are some of the disorders that affect calcium metabolism, for which we have provided a brief overview. ... Calcium is stored in the bones. Calcium levels in the blood are regulated by two hormones produced by the four parathyroid ...
more infohttps://chw.org/medical-care/endocrine/endocrine-conditions/disorders-affecting-calcium-metabolism

Browsing  by Subject Calcium Metabolism DisordersBrowsing by Subject "Calcium Metabolism Disorders"

Calcium and magnesium in drinking water : public health significance  World Health Organization (‎World Health ... "Calcium Metabolism Disorders". 0-9. A. B. C. D. E. F. G. H. I. J. K. L. M. N. O. P. Q. R. S. T. U. V. W. X. Y. Z. * 0-9 ...
more infohttps://extranet.who.int/iris/restricted/browse?authority=Calcium+Metabolism+Disorders&type=mesh

Browsing Publications by Subject Calcium Metabolism DisordersBrowsing Publications by Subject "Calcium Metabolism Disorders"

... 0-9. A. B. C. D. E. F. G. H. I. J. K. L. M. N. O. P. Q. R. S. ... Calcium and magnesium in drinking water : public health significance  World Health Organization (‎World Health ...
more infohttps://extranet.who.int/iris/restricted/handle/10665/26724/browse?authority=Calcium+Metabolism+Disorders&type=mesh

Disorders of calcium metabolism - wikidocDisorders of calcium metabolism - wikidoc

Disorders of calcium metabolism occur when the body has too little or too much calcium. The serum level of calcium is closely ... Directions to Hospitals Treating Disorders of calcium metabolism Risk calculators and risk factors for Disorders of calcium ... Articles on Disorders of calcium metabolism in N Eng J Med, Lancet, BMJ ... and therefore levels of ionized calcium are better measures than a total calcium; however, one can correct a total calcium if ...
more infohttps://www.wikidoc.org/index.php/Disorders_of_calcium_metabolism

Disorders of calcium metabolism - WikipediaDisorders of calcium metabolism - Wikipedia

Disorders of calcium metabolism occur when the body has too little or too much calcium. The serum level of calcium is closely ... Disorders in calcium metabolism can lead to hypocalcemia, decreased plasma levels of calcium or hypercalcemia, elevated plasma ... and therefore levels of ionized calcium are better measures than a total calcium; however, one can correct a total calcium if ... A normal ionized calcium is 1.12-1.45 mmol/L (4.54-5.61 mg/dL). A normal total calcium is 2.2-2.6 mmol/L (9-10.5 mg/dl). Total ...
more infohttps://en.wikipedia.org/wiki/Disorders_of_calcium_metabolism

Quiz: Disorders of Calcium Metabolism - Merck Veterinary ManualQuiz: Disorders of Calcium Metabolism - Merck Veterinary Manual

Merck & Co., Inc., Kenilworth, NJ, USA is a global healthcare leader working to help the world be well. From developing new therapies that treat and prevent disease to helping people in need, we are committed to improving health and well-being around the world. The Merck Veterinary Manual was first published in 1955 as a service to the community. The legacy of this great resource continues as the Merck Veterinary Manual in the US and Canada and the MSD Manual outside of North America.. ...
more infohttp://www.merckvetmanual.com/en-pr/multimedia/quiz/625

Calcium Metabolism Disorders - The Clinical AdvisorCalcium Metabolism Disorders - The Clinical Advisor

What happens to patients with calcium metabolism disorders? Hypercalcemia is a common disorder that can present a challenge to ... Intravenous calcium comes in two forms: calcium gluconate or calcium chloride. Oral calcium comes in several forms, the most ... What is the cause of this patients calcium metabolism disorder? * Hypercalcemia * What are the key signs and symptoms of ... calcium acetate and calcium citrate. The amount of calcium in each preparation is shown in Table 5. . Table 5.. Calcium ...
more infohttps://www.clinicaladvisor.com/nephrology-hypertension/calcium-metabolism-disorders/article/616216/

NewYork-Presbyterian Queens - Disorders Affecting Calcium MetabolismNewYork-Presbyterian Queens - Disorders Affecting Calcium Metabolism

Calcium is stored in the bones.. Disorders affecting calcium metabolism require clinical care by a physician or other health ... Disorders Affecting Calcium Metabolism. Calcium plays an important role in several body functions, including muscle ... Listed in the directory below are some of the disorders that affect calcium metabolism, for which we have provided a brief ... Home , Content Library of Ped English Medical Content , Diabetes and Other Endocrine and Metabolic Disorders ...
more infohttp://www.nyhq.org/diw/content.asp?pageid=P05047

Overview of the Parathyroid Glands and Disorders of Calcium Metabolism - Endocrine System - Merck Veterinary ManualOverview of the Parathyroid Glands and Disorders of Calcium Metabolism - Endocrine System - Merck Veterinary Manual

Learn about the veterinary topic of Overview of the Parathyroid Glands and Disorders of Calcium Metabolism. Find specific ... The Parathyroid Glands and Disorders of Calcium Metabolism *. Overview of the Parathyroid Glands and Disorders of Calcium ... The Parathyroid Glands and Disorders of Calcium Metabolism *. Overview of the Parathyroid Glands and Disorders of Calcium ... Overview of the Parathyroid Glands and Disorders of Calcium Metabolism By Mark E. Peterson, DVM, DACVIM, Director of ...
more infohttp://www.merckvetmanual.com/en-pr/endocrine-system/the-parathyroid-glands-and-disorders-of-calcium-metabolism/overview-of-the-parathyroid-glands-and-disorders-of-calcium-metabolism

Neurological Disorders May be Caused by Defective Calcium Metabolism - Endowment for Medical Research - FREE Education -...Neurological Disorders May be Caused by Defective Calcium Metabolism - Endowment for Medical Research - FREE Education -...

Neurological Disorders May be Caused by Defective Calcium Metabolism ... Neurological Disorders May be Caused by Defective Calcium Metabolism. Comments by J.C. Spencer ... Concerning calcium metabolism I stated, "Usually the enzym calpain, which depends on calcium for its activity, keeps the ... I discuss defective calcium metabolism in my book Expand Your Mind - Improve Your Brain in Chapter 32 entitled Age well - He ...
more infohttp://www.endowmentmed.org/content/view/926/106/

Disorders of the Parathyroids & Calcium and Phosphorus Metabolism | Pathophysiology of Disease: An Introduction to Clinical...Disorders of the Parathyroids & Calcium and Phosphorus Metabolism | Pathophysiology of Disease: An Introduction to Clinical...

"Disorders of the Parathyroids & Calcium and Phosphorus Metabolism." Pathophysiology of Disease: An Introduction to Clinical ... Shoback D.M. Shoback, Dolores M.Disorders of the Parathyroids & Calcium and Phosphorus Metabolism. In: Hammer GD, McPhee SJ. ... This chapter presents a general overview of the key hormones involved regulating calcium, phosphate, and bone mineral ... metabolism. These include parathyroid hormone, vitamin D-principally the 1,25-(OH)2 vitamin D metabolite (1,25- ...
more infohttps://accessmedicine.mhmedical.com/content.aspx?bookid=2468§ionid=198223448

2017/18 ICD-10-CM Diagnosis Code E83.50: Unspecified disorder of calcium metabolism2017/18 ICD-10-CM Diagnosis Code E83.50: Unspecified disorder of calcium metabolism

Unspecified disorder of calcium metabolism. 2016 2017 2018 Billable/Specific Code *E83.50 is a billable/specific ICD-10-CM code ... Disorders of calcium metabolism. 2016 2017 2018 Non-Billable/Non-Specific Code Type 1 Excludes*chondrocalcinosis (M11.1-M11.2) ... Hypercalciuria (excess calcium in urine). Clinical Information *Disorders in the processing of calcium in the body: its ... 640 Miscellaneous disorders of nutrition, metabolism , fluids and electrolytes with mcc. *641 Miscellaneous disorders of ...
more infohttp://www.icd10data.com/ICD10CM/Codes/E00-E89/E70-E88/E83-/E83.50

Top Calcium Metabolism Disorders Hospitals in Bangalore  | CredihealthTop Calcium Metabolism Disorders Hospitals in Bangalore | Credihealth

Get guidance from medical experts to select best calcium metabolism disorders hospital in Bangalore ... View details of top calcium metabolism disorders hospitals in Bangalore. ... Best hospitals for calcium-metabolism-disorders in Bangalore List of best hospitals for calcium-metabolism-disorders in ... Need help in choosing the right calcium metabolism disorders hospital? The medical expert will guide you for all hospital needs ...
more infohttps://www.credihealth.com/hospitals/bangalore/calcium-metabolism-disorders

Calcium-sensing receptor (CaSR) mutations and disorders of calcium, electrolyte and water metabolism - Radcliffe Department of...Calcium-sensing receptor (CaSR) mutations and disorders of calcium, electrolyte and water metabolism - Radcliffe Department of...

Gain-of-function mutations, on the other hand, result in the hypocalcemic disorders of autosomal dominant hypocalcemia and ... Loss-of-function mutations lead to three hypercalcemic disorders, which are familial hypocalciuric hypercalcemia (FHH), ... The extracellular calcium-sensing receptor (CaSR) is a family C G-protein-coupled receptor (GPCR) that is expressed at multiple ... Calcium-sensing receptor (CaSR) mutations and disorders of calcium, electrolyte and water metabolism ...
more infohttps://www.rdm.ox.ac.uk/publications/415682

Disorders of Calcium Metabolism | Comprehensive Pediatric Hospital Medicine, 2e | AccessPediatrics | McGraw-Hill MedicalDisorders of Calcium Metabolism | Comprehensive Pediatric Hospital Medicine, 2e | AccessPediatrics | McGraw-Hill Medical

"Disorders of Calcium Metabolism." Comprehensive Pediatric Hospital Medicine, 2e Zaoutis LB, Chiang VW. Zaoutis L.B., Chiang V.W ... Kenigsberg L, Agarwal C. Kenigsberg L, Agarwal C Kenigsberg, Lisa, and Chhavi Agarwal.Disorders of Calcium Metabolism. In: ... Total serum calcium levels include both ionized and bound calcium. The total calcium level reflects serum changes in albumin, ... The majority of total body calcium exists as bone mineral, with serum calcium representing less than 1% of total body calcium. ...
more infohttp://accesspediatrics.mhmedical.com/content.aspx?bookid=2216§ionid=170332179

Dr. Morris Kliger, DO - Lansdale, PA - Family Medicine | Healthgrades.comDr. Morris Kliger, DO - Lansdale, PA - Family Medicine | Healthgrades.com

Calcium Metabolism Disorders. *Carpal Tunnel Syndrome. *Cellulitis. *Chest Pain. *Chronic Fatigue Syndrome ...
more infohttps://www.healthgrades.com/physician/dr-morris-kliger-yhm4v

Dr. John Stevenson, MD - Reviews - San Angelo, TXDr. John Stevenson, MD - Reviews - San Angelo, TX

Brain Disorders. *Calcium Metabolism Disorders. *Chronic Glomerulonephritis. *Chronic Kidney Diseases. *Classic Polyarteritis ...
more infohttps://www.healthgrades.com/physician/dr-john-stevenson-2jpl4

Mechanical Stress Effects on the Cardiovascular Adaptations of Peripheral Arterial Calcifications Among Athletes - Full Text...Mechanical Stress Effects on the Cardiovascular Adaptations of Peripheral Arterial Calcifications Among Athletes - Full Text...

Calcium Metabolism Disorders. Metabolic Diseases. Vascular Calcification. To Top. *For Patients and Families ... Serum calcium [ Time Frame: Baseline (Day 0; transversal study) ]. mmol/l. *Serum phosphorus [ Time Frame: Baseline (Day 0; ... Dietary calcium intake [ Time Frame: Baseline (Day 0; transversal study) ]. mg/day ... Volunteers without cardiovascular disease, glucose regulation disorders or known renal disease. Inclusion Criteria for athletic ...
more infohttps://clinicaltrials.gov/show/NCT01577576

Investigations of the Effect of MK-7 on Bone and Glucose Metabolism and Arterial Calcification - Full Text View -...Investigations of the Effect of MK-7 on Bone and Glucose Metabolism and Arterial Calcification - Full Text View -...

Calcium Metabolism Disorders. Metabolic Diseases. Musculoskeletal Diseases. Vitamins. Vitamin A. Micronutrients. Growth ... Treatment with drugs with known effects on bone metabolism or glucose metabolism. ... Investigations of the Effect of MK-7 on Bone and Glucose Metabolism and Arterial Calcification (K2vita). The safety and ... Investigations of the Effect of MK-7 on Bone and Glucose Metabolism and Arterial Calcification. ...
more infohttps://clinicaltrials.gov/ct2/show/NCT01922804?recr=Open&cond=%22Bone+Diseases%22&rank=19

Warfarin and Coronary Calcification Project - Full Text View - ClinicalTrials.govWarfarin and Coronary Calcification Project - Full Text View - ClinicalTrials.gov

Patients without known coronary heart disease, disorders of calcium metabolism or chronic kidney disease aged , 18 years who ...
more infohttps://www.clinicaltrials.gov/ct2/show/NCT00868712?term=warfarin+AND+Vitamin+K&rank=75

Warfarin and Coronary Calcification Project - Full Text View - ClinicalTrials.govWarfarin and Coronary Calcification Project - Full Text View - ClinicalTrials.gov

Patients without known coronary heart disease, disorders of calcium metabolism or chronic kidney disease aged , 18 years who ...
more infohttps://www.clinicaltrials.gov/ct2/show/NCT00868712?term=warfarin+AND+International&rank=14

Aimee D. Shu | Stanford Medicine ProfilesAimee D. Shu | Stanford Medicine Profiles

I enjoy treating patients with menstrual disorders, menopause, fractures, osteoporosis, parathyroid imbalance, and calcium ... Board Certification: Endocrinology, Diabetes and Metabolism, American Board of Internal Medicine (2008) ... Fellowship, Columbia University Medical Center, New York, NY, endocrinology, diabetes & metabolism (2009) ... METABOLISM Yin, M. T., McMahon, D. J., Ferris, D. C., Zhang, C. A., Shu, A., Staron, R., Colon, I., Laurence, J., Dobkin, J. F ...
more infohttps://med.stanford.edu/profiles/aimee-shu

Browsing Publications by SubjectBrowsing Publications by Subject

Calcium [‎3]‎. Calcium Metabolism Disorders [‎1]‎. Calcium, Dietary [‎4]‎. Cambodia [‎8]‎. Cameroon [‎1]‎. ...
more infohttps://apps.who.int/iris/handle/10665/26724/browse?rpp=20&sort_by=-1&type=mesh&etal=-1&starts_with=C&order=ASC
  • If you cannot find the information in which you are interested, please visit the Diabetes & Other Endocrine and Metabolic Disorders Online Resources page in this website for an Internet address that may contain additional information on that topic. (nyhq.org)
  • The majority (60%-70%) of calcium is reabsorbed passively in the proximal tubule driven by a gradient that is generated by sodium and water reabsorption. (mhmedical.com)
  • I discuss defective calcium metabolism in my book Expand Your Mind - Improve Your Brain in Chapter 32 entitled Age well - He who finishes last, finishes well . (endowmentmed.org)
  • Calcium levels in the blood are regulated by two hormones produced by the four parathyroid glands, glands located adjacent to the thyroid gland in the neck. (chw.org)
  • These hormones also stimulate the gastrointestinal tract to absorb calcium and the bones to release calcium. (chw.org)
  • Calcium absorption and regulation involves a complex interplay between multiple organ systems and regulatory hormones. (mhmedical.com)
  • Abnormal calcium release is toxic to cells and results in impaired motor function, said Dr. Ilya Bezprozvanny, professor of physiology at UT Southwestern and senior author of the study published in the Nov. 26 issue of the Journal of Neuroscience . (endowmentmed.org)
  • Assessment and management of patients with abnormal calcium. (medscape.com)
  • Concerning calcium metabolism I stated, "Usually the enzym calpain, which depends on calcium for its activity, keeps the buildup of protein down . (endowmentmed.org)
  • The module will cover the key molecules involved in metabolism, cell division and protein expression within the human body, showing the relationships between these processes and the key differences in distinct tissues. (bangor.ac.uk)
  • Calcium plays an important role in several body functions, including muscle contractions, enzyme function, and nerve conduction. (chw.org)
  • Calcium also plays a unique role in intracellular signaling and is involved in the regulation of enzyme activity. (mhmedical.com)
  • A normal total calcium is 2.2-2.6 mmol/L (9-10.5 mg/dl). (wikidoc.org)
  • Total calcium of less than 8.0 mg/dL is hypocalcaemia , with levels below 1.59 mmol/L (6 mg/dL) generally fatal. (wikidoc.org)
  • Total calcium of more than 11.111 mg/dL is hypercalcaemia , with levels over 3.753 mmol/L (15.12 mg/dL) generally fatal. (wikidoc.org)
  • A normal ionized calcium is 1.12-1.45 mmol/L (4.54-5.61 mg/dL). (wikidoc.org)
  • Ionized calcium, which is responsible for the physiologic effects, is maintained under normal conditions within a narrow normal range of approximately 4.5 to 5.3 ng/dL (1.12-1.32 mmol/L), with higher levels in neonates and infants. (mhmedical.com)
  • Ionized calcium may be reduced by exogenous factors such as citrate from transfused blood or free fatty acids from total parenteral nutrition. (mhmedical.com)