Ionophores: Chemical agents that increase the permeability of biological or artificial lipid membranes to specific ions. Most ionophores are relatively small organic molecules that act as mobile carriers within membranes or coalesce to form ion permeable channels across membranes. Many are antibiotics, and many act as uncoupling agents by short-circuiting the proton gradient across mitochondrial membranes.Lasalocid: Cationic ionophore antibiotic obtained from Streptomyces lasaliensis that, among other effects, dissociates the calcium fluxes in muscle fibers. It is used as a coccidiostat, especially in poultry.Calcimycin: An ionophorous, polyether antibiotic from Streptomyces chartreusensis. It binds and transports CALCIUM and other divalent cations across membranes and uncouples oxidative phosphorylation while inhibiting ATPase of rat liver mitochondria. The substance is used mostly as a biochemical tool to study the role of divalent cations in various biological systems.Ionomycin: A divalent calcium ionophore that is widely used as a tool to investigate the role of intracellular calcium in cellular processes.EthersCalcium Ionophores: Chemical agents that increase the permeability of CELL MEMBRANES to CALCIUM ions.Calcium: A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.Egtazic Acid: A chelating agent relatively more specific for calcium and less toxic than EDETIC ACID.Tetradecanoylphorbol Acetate: A phorbol ester found in CROTON OIL with very effective tumor promoting activity. It stimulates the synthesis of both DNA and RNA.Calcium Signaling: Signal transduction mechanisms whereby calcium mobilization (from outside the cell or from intracellular storage pools) to the cytoplasm is triggered by external stimuli. Calcium signals are often seen to propagate as waves, oscillations, spikes, sparks, or puffs. The calcium acts as an intracellular messenger by activating calcium-responsive proteins.Nigericin: A polyether antibiotic which affects ion transport and ATPase activity in mitochondria. It is produced by Streptomyces hygroscopicus. (From Merck Index, 11th ed)Monensin: An antiprotozoal agent produced by Streptomyces cinnamonensis. It exerts its effect during the development of first-generation trophozoites into first-generation schizonts within the intestinal epithelial cells. It does not interfere with hosts' development of acquired immunity to the majority of coccidial species. Monensin is a sodium and proton selective ionophore and is widely used as such in biochemical studies.Cells, Cultured: Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.Valinomycin: A cyclododecadepsipeptide ionophore antibiotic produced by Streptomyces fulvissimus and related to the enniatins. It is composed of 3 moles each of L-valine, D-alpha-hydroxyisovaleric acid, D-valine, and L-lactic acid linked alternately to form a 36-membered ring. (From Merck Index, 11th ed) Valinomycin is a potassium selective ionophore and is commonly used as a tool in biochemical studies.Calcium Channels: Voltage-dependent cell membrane glycoproteins selectively permeable to calcium ions. They are categorized as L-, T-, N-, P-, Q-, and R-types based on the activation and inactivation kinetics, ion specificity, and sensitivity to drugs and toxins. The L- and T-types are present throughout the cardiovascular and central nervous systems and the N-, P-, Q-, & R-types are located in neuronal tissue.Calcium, Dietary: Calcium compounds used as food supplements or in food to supply the body with calcium. Dietary calcium is needed during growth for bone development and for maintenance of skeletal integrity later in life to prevent osteoporosis.Potassium Ionophores: Chemical agents that increase the permeability of CELL MEMBRANES to POTASSIUM ions.Calcium Carbonate: Carbonic acid calcium salt (CaCO3). An odorless, tasteless powder or crystal that occurs in nature. It is used therapeutically as a phosphate buffer in hemodialysis patients and as a calcium supplement.Carbonyl Cyanide m-Chlorophenyl Hydrazone: A proton ionophore. It is commonly used as an uncoupling agent and inhibitor of photosynthesis because of its effects on mitochondrial and chloroplast membranes.Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone: A proton ionophore that is commonly used as an uncoupling agent in biochemical studies.Sodium Ionophores: Chemical agents that increase the permeability of CELL MEMBRANES to SODIUM ions.Calcium Phosphates: Calcium salts of phosphoric acid. These compounds are frequently used as calcium supplements.Calcium Isotopes: Stable calcium atoms that have the same atomic number as the element calcium, but differ in atomic weight. Ca-42-44, 46, and 48 are stable calcium isotopes.Calcium Chloride: A salt used to replenish calcium levels, as an acid-producing diuretic, and as an antidote for magnesium poisoning.Gramicidin: A group of peptide antibiotics from BACILLUS brevis. Gramicidin C or S is a cyclic, ten-amino acid polypeptide and gramicidins A, B, D are linear. Gramicidin is one of the two principal components of TYROTHRICIN.Hydrogen-Ion Concentration: The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH = log 1/2[1/(H+)], where (H+) is the hydrogen ion concentration in gram equivalents per liter of solution. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Kinetics: The rate dynamics in chemical or physical systems.Potassium: An element in the alkali group of metals with an atomic symbol K, atomic number 19, and atomic weight 39.10. It is the chief cation in the intracellular fluid of muscle and other cells. Potassium ion is a strong electrolyte that plays a significant role in the regulation of fluid volume and maintenance of the WATER-ELECTROLYTE BALANCE.Membrane Potentials: The voltage differences across a membrane. For cellular membranes they are computed by subtracting the voltage measured outside the membrane from the voltage measured inside the membrane. They result from differences of inside versus outside concentration of potassium, sodium, chloride, and other ions across cells' or ORGANELLES membranes. For excitable cells, the resting membrane potentials range between -30 and -100 millivolts. Physical, chemical, or electrical stimuli can make a membrane potential more negative (hyperpolarization), or less negative (depolarization).Calcium Channels, L-Type: Long-lasting voltage-gated CALCIUM CHANNELS found in both excitable and nonexcitable tissue. They are responsible for normal myocardial and vascular smooth muscle contractility. Five subunits (alpha-1, alpha-2, beta, gamma, and delta) make up the L-type channel. The alpha-1 subunit is the binding site for calcium-based antagonists. Dihydropyridine-based calcium antagonists are used as markers for these binding sites.Biological Transport, Active: The movement of materials across cell membranes and epithelial layers against an electrochemical gradient, requiring the expenditure of metabolic energy.Furans: Compounds with a 5-membered ring of four carbons and an oxygen. They are aromatic heterocycles. The reduced form is tetrahydrofuran.Calcium Oxalate: The calcium salt of oxalic acid, occurring in the urine as crystals and in certain calculi.ButylaminesCalcium Gluconate: The calcium salt of gluconic acid. The compound has a variety of uses, including its use as a calcium replenisher in hypocalcemic states.Sodium: A member of the alkali group of metals. It has the atomic symbol Na, atomic number 11, and atomic weight 23.Biological Transport: The movement of materials (including biochemical substances and drugs) through a biological system at the cellular level. The transport can be across cell membranes and epithelial layers. It also can occur within intracellular compartments and extracellular compartments.Calcium Radioisotopes: Unstable isotopes of calcium that decay or disintegrate emitting radiation. Ca atoms with atomic weights 39, 41, 45, 47, 49, and 50 are radioactive calcium isotopes.Adenosine Triphosphate: An adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.Lanthanum: Lanthanum. The prototypical element in the rare earth family of metals. It has the atomic symbol La, atomic number 57, and atomic weight 138.91. Lanthanide ion is used in experimental biology as a calcium antagonist; lanthanum oxide improves the optical properties of glass.Magnesium: A metallic element that has the atomic symbol Mg, atomic number 12, and atomic weight 24.31. It is important for the activity of many enzymes, especially those involved in OXIDATIVE PHOSPHORYLATION.Ion-Selective Electrodes: Electrodes which can be used to measure the concentration of particular ions in cells, tissues, or solutions.Arsenazo III: Metallochrome indicator that changes color when complexed to the calcium ion under physiological conditions. It is used to measure local calcium ion concentrations in vivo.Proton Ionophores: Chemical agents that increase the permeability of CELL MEMBRANES to PROTONS.Potentiometry: Solution titration in which the end point is read from the electrode-potential variations with the concentrations of potential determining ions. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Thapsigargin: A sesquiterpene lactone found in roots of THAPSIA. It inhibits CA(2+)-TRANSPORTING ATPASE mediated uptake of CALCIUM into SARCOPLASMIC RETICULUM.Cattle: Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.MethylaminesCalcium Compounds: Inorganic compounds that contain calcium as an integral part of the molecule.Chelating Agents: Chemicals that bind to and remove ions from solutions. Many chelating agents function through the formation of COORDINATION COMPLEXES with METALS.Calcium Channels, N-Type: CALCIUM CHANNELS that are concentrated in neural tissue. Omega toxins inhibit the actions of these channels by altering their voltage dependence.Ruminants: A suborder of the order ARTIODACTYLA whose members have the distinguishing feature of a four-chambered stomach, including the capacious RUMEN. Horns or antlers are usually present, at least in males.2,4-Dinitrophenol: A toxic dye, chemically related to trinitrophenol (picric acid), used in biochemical studies of oxidative processes where it uncouples oxidative phosphorylation. It is also used as a metabolic stimulant. (Stedman, 26th ed)Veterinary Drugs: Drugs used by veterinarians in the treatment of animal diseases. The veterinarian's pharmacological armamentarium is the counterpart of drugs treating human diseases, with dosage and administration adjusted to the size, weight, disease, and idiosyncrasies of the species. In the United States most drugs are subject to federal regulations with special reference to the safety of drugs and residues in edible animal products.Dicyclohexylcarbodiimide: A carbodiimide that is used as a chemical intermediate and coupling agent in peptide synthesis. (From Hawley's Condensed Chemical Dictionary, 12th ed)Cytosol: Intracellular fluid from the cytoplasm after removal of ORGANELLES and other insoluble cytoplasmic components.Protons: Stable elementary particles having the smallest known positive charge, found in the nuclei of all elements. The proton mass is less than that of a neutron. A proton is the nucleus of the light hydrogen atom, i.e., the hydrogen ion.Salicylanilides: 2-Hydroxy-N-phenylbenzamides. N-phenyl substituted salicylamides. Derivatives have been used as fungicides, anti-mildew agents and topical antifungal agents. In concentrated form may cause irritation of skin and mucous membranes.Calcium Channel Agonists: Agents that increase calcium influx into calcium channels of excitable tissues. This causes vasoconstriction in VASCULAR SMOOTH MUSCLE and/or CARDIAC MUSCLE cells as well as stimulation of insulin release from pancreatic islets. Therefore, tissue-selective calcium agonists have the potential to combat cardiac failure and endocrinological disorders. They have been used primarily in experimental studies in cell and tissue culture.Coccidiostats: Agents useful in the treatment or prevention of COCCIDIOSIS in man or animals.Anti-Bacterial Agents: Substances that reduce the growth or reproduction of BACTERIA.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Cations, Divalent: Positively charged atoms, radicals or groups of atoms with a valence of plus 2, which travel to the cathode or negative pole during electrolysis.Fluorescent Dyes: Agents that emit light after excitation by light. The wave length of the emitted light is usually longer than that of the incident light. Fluorochromes are substances that cause fluorescence in other substances, i.e., dyes used to mark or label other compounds with fluorescent tags.Terpenes: A class of compounds composed of repeating 5-carbon units of HEMITERPENES.Ammonium Chloride: An acidifying agent that has expectorant and diuretic effects. Also used in etching and batteries and as a flux in electroplating.Aminoquinolines: Quinolines substituted in any position by one or more amino groups.Cell Line: Established cell cultures that have the potential to propagate indefinitely.Cell Membrane Permeability: A quality of cell membranes which permits the passage of solvents and solutes into and out of cells.Dose-Response Relationship, Drug: The relationship between the dose of an administered drug and the response of the organism to the drug.Uncoupling Agents: Chemical agents that uncouple oxidation from phosphorylation in the metabolic cycle so that ATP synthesis does not occur. Included here are those IONOPHORES that disrupt electron transfer by short-circuiting the proton gradient across mitochondrial membranes.Rabbits: The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.Potassium Cyanide: A highly poisonous compound that is an inhibitor of many metabolic processes, but has been shown to be an especially potent inhibitor of heme enzymes and hemeproteins. It is used in many industrial processes.Edetic Acid: A chelating agent that sequesters a variety of polyvalent cations such as CALCIUM. It is used in pharmaceutical manufacturing and as a food additive.Cations: Positively charged atoms, radicals or groups of atoms which travel to the cathode or negative pole during electrolysis.Calcium Hydroxide: A white powder prepared from lime that has many medical and industrial uses. It is in many dental formulations, especially for root canal filling.Liposomes: Artificial, single or multilaminar vesicles (made from lecithins or other lipids) that are used for the delivery of a variety of biological molecules or molecular complexes to cells, for example, drug delivery and gene transfer. They are also used to study membranes and membrane proteins.Phosphorus: A non-metal element that has the atomic symbol P, atomic number 15, and atomic weight 31. It is an essential element that takes part in a broad variety of biochemical reactions.Rumen: The first stomach of ruminants. It lies on the left side of the body, occupying the whole of the left side of the abdomen and even stretching across the median plane of the body to the right side. It is capacious, divided into an upper and a lower sac, each of which has a blind sac at its posterior extremity. The rumen is lined by mucous membrane containing no digestive glands, but mucus-secreting glands are present in large numbers. Coarse, partially chewed food is stored and churned in the rumen until the animal finds circumstances convenient for rumination. When this occurs, little balls of food are regurgitated through the esophagus into the mouth, and are subjected to a second more thorough mastication, swallowed, and passed on into other parts of the compound stomach. (From Black's Veterinary Dictionary, 17th ed)PyransModels, Biological: Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.Nifedipine: A potent vasodilator agent with calcium antagonistic action. It is a useful anti-anginal agent that also lowers blood pressure.Clioquinol: A potentially neurotoxic 8-hydroxyquinoline derivative long used as a topical anti-infective, intestinal antiamebic, and vaginal trichomonacide. The oral preparation has been shown to cause subacute myelo-optic neuropathy and has been banned worldwide.Calcium Sulfate: A calcium salt that is used for a variety of purposes including: building materials, as a desiccant, in dentistry as an impression material, cast, or die, and in medicine for immobilizing casts and as a tablet excipient. It exists in various forms and states of hydration. Plaster of Paris is a mixture of powdered and heat-treated gypsum.Osmolar Concentration: The concentration of osmotically active particles in solution expressed in terms of osmoles of solute per liter of solution. Osmolality is expressed in terms of osmoles of solute per kilogram of solvent.Dinitrophenols: Organic compounds that contain two nitro groups attached to a phenol.Parathyroid Hormone: A polypeptide hormone (84 amino acid residues) secreted by the PARATHYROID GLANDS which performs the essential role of maintaining intracellular CALCIUM levels in the body. Parathyroid hormone increases intracellular calcium by promoting the release of CALCIUM from BONE, increases the intestinal absorption of calcium, increases the renal tubular reabsorption of calcium, and increases the renal excretion of phosphates.Ions: An atom or group of atoms that have a positive or negative electric charge due to a gain (negative charge) or loss (positive charge) of one or more electrons. Atoms with a positive charge are known as CATIONS; those with a negative charge are ANIONS.Membranes, Artificial: Artificially produced membranes, such as semipermeable membranes used in artificial kidney dialysis (RENAL DIALYSIS), monomolecular and bimolecular membranes used as models to simulate biological CELL MEMBRANES. These membranes are also used in the process of GUIDED TISSUE REGENERATION.Cyclic AMP: An adenine nucleotide containing one phosphate group which is esterified to both the 3'- and 5'-positions of the sugar moiety. It is a second messenger and a key intracellular regulator, functioning as a mediator of activity for a number of hormones, including epinephrine, glucagon, and ACTH.Carboxylic Acids: Organic compounds containing the carboxy group (-COOH). This group of compounds includes amino acids and fatty acids. Carboxylic acids can be saturated, unsaturated, or aromatic.Intracellular Membranes: Thin structures that encapsulate subcellular structures or ORGANELLES in EUKARYOTIC CELLS. They include a variety of membranes associated with the CELL NUCLEUS; the MITOCHONDRIA; the GOLGI APPARATUS; the ENDOPLASMIC RETICULUM; LYSOSOMES; PLASTIDS; and VACUOLES.Fura-2: A fluorescent calcium chelating agent which is used to study intracellular calcium in tissues.

Changes in content and localization of proteins phosphorylated at tyrosine, serine and threonine residues during ram sperm capacitation and acrosome reaction. (1/68)

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The use of anti-VDAC2 antibody for the combined assessment of human sperm acrosome integrity and ionophore A23187-induced acrosome reaction. (2/68)

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Ultrastructure and intracellular calcium response during activation in vitrified and slow-frozen human oocytes. (3/68)

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Effects of FK506 and cyclosporin a on calcium ionophore-induced mitochondrial depolarization and cytosolic calcium in astrocytes and neurons. (4/68)

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Calpain-cleaved type 1 inositol 1,4,5-trisphosphate receptor (InsP(3)R1) has InsP(3)-independent gating and disrupts intracellular Ca(2+) homeostasis. (5/68)

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Activation of human vascular cells decreases their expression of transforming growth factor-beta. (6/68)

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Chromatin disruption in the promoter of bovine leukemia virus during transcriptional activation. (7/68)

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The redox state of transglutaminase 2 controls arterial remodeling. (8/68)

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Sophoricoside exhibits numerous pharmacological effects, including anti- inflammatory and anti-cancer actions, yet the exact mechanism that accounts for the anti-allergic effects of sophoricoside is not completely understood. The aim of the present study was to elucidate whether and how sophoricoside modulates the mast cell-mediated allergic inflammation in vitro and in vivo. We investigated the pharmacological effects of sophoricoside on both compound 48/80 or histamine-induced scratching behaviors and 2,4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis in mice. Additionally, to find a possible explanation for the anti-inflammatory effects of sophoricoside, we evaluated the effects of sophoricoside on the production of histamine and inflammatory cytokines and activation of nuclear factor-κB (NF-κB) and caspase-1 in phorbol 12-myristate 13-acetate plus calcium ionophore A23187 (PMACI)-stimulated human mast cells (HMC-1). The finding of this study demonstrated that sophoricoside reduced
The data presented above indicate that Ano6, 8 and 9, when overexpressed in HEK293 cells, produce Cl− currents upon increase in intracellular Ca2+ by ionomycin. However, although all three paralogs are expressed endogenously in HEK293 cells, no currents are activated in mock-transfected cells (Fig. 3A) (Almaça et al., 2009). However, when increasing [Ca2+]i to very high levels (≥10 µM), endogenous anoctamins were activated (Fig. 3B,E). This may be due to a lack of sufficient membrane expression of endogenous anoctamins. Endogenous anoctamins are expressed at much lower levels than overexpressed proteins and may be inhibited by endogenous accessory proteins, such as CAMKII. Alternatively, specific Ca2+ release and/or influx pathways need to be triggered to activate these endogenous anoctamins. The overall linear structures appear similar in all anoctamins (supplementary material Fig. S1) and an analysis of putative functional domains revealed a number of similar motifs and putative ...
Volumenregulation ist ein grundlegender Mechanismus, der für alle lebenden Organismen notwendig ist. Zellen schwellen unter einem hypo- osmotischen Schock und aktivieren darauf die Freisetzung von K+ und Cl- Ionen über die Aktivierung von K+- und Cl-- Kanälen, um das Ausgangsvolumen wieder herzustellen. Im Jahre 2014 wurde von zwei unabhängigen Arbeitsgruppen LRRC8A als Hauptkomponente des Volumen- Regulierten Anionen Canals (VRAC) identifiziert. Die Ergebnisse der vorliegenden Arbeit lassen aber vermuten, dass auch Anoctamine und Bestrophine an der Volumenregulation beteiligt sind. Darüber hinaus konnte für diese Proteine der Mechanismus ihrer zellvolumen-abhängigen Aktivierung geklärt werden. Zusätzlich wurde in dieser Arbeit die Rolle der TMC Proteine (TransMembrane Channel-like family of Proteins), die eine hohe Sequenzähnlichkeit zu den Anoctaminen besitzen, für die Volumenregulation und für die Regulation der intrazellulären Ca2+ Konzentration untersucht. Überexpression von ...
Histopathological assessment of the anti-osteoporosis effect of sophoricoside.Normal group (A) shows normal bony tissue with intact well-formed dense trabeculae
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Anoctamins and Bestrophins are two kinds of calcium-activated chloride channels. Anoctamins were shown to be Ca-activated Cl channels in 2008 and are responsible for the classical CaCCs that are widely expressed in many tissues, especially epithelia. Bestrophins are more restricted in their expression and play more specialized roles. Bestrophin-1 is expressed in the retinal pigment epithelium and certain mutations in bestrophin-1 cause degeneration of the retina and blindness. Bestrophin-2 is expressed in goblet cells in colon and may play a role in bicarbonate secretion in this tissue. We are interested in understanding how both anoctamins and bestrophins are regulated by calcium. We are identifying the calcium binding sites and the molecular links between the calcium sensor and the channel gate using a combination of both whole-cell and single channel electrophysiological mesurements and mutagenesis. We are dissecting the signaling protein network associated with these channels using ...
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Kit Component:- KN304792G1, Dpy19l1 gRNA vector 1 in pCas-Guide vector- KN304792G2, Dpy19l1 gRNA vector 2 in pCas-Guide vector- KN304792D, donor…
Taylor, SRJ, Gonzalez-Begne, M, Dewhurst, S, Chimini, G, Higgins, CF, Melvin, JE and Elliott, JI (2008) Sequential shrinkage and swelling underlie P2X(7)-stimulated lymphocyte phosphatidylserine exposure and death ...
APhA DrugInfoLine (ISSN 2162-3015) is a weekly publication of, and is owned and copyrighted by the American Pharmacists Association, the national professional society of pharmacists. Materials in APhA DrugInfoLine do not neccessarily represent the policy, recommendations, or endorsement of APhA. The publisher, authors, editors, reviewers, and contributors have taken care to ensure that the information contained in APhA DrugInfoLine is accurate and current; however, they shall have no ability to any person or entity with regard to claims, losses, or damage caused or alleged to be caused, directly or indirectly by use of any information contained in the publication. All decisions about drug therapy must be based on independent judgement of the clinician.. ...
Ano ano ba ang mga gamot na pampatigas - inda dadaesen Ang Lungsod - W2C - Web To Corpus. Ideal for treating acne spots directly.
Tmem18兔多克隆抗体(ab106597)可与小鼠, 大鼠, 人样本反应并经WB, IHC, ICC/IF实验严格验证。所有产品均提供质保服务,中国75%以上现货。
Sluyter, R., Shemon, A. & Wiley, J. S. (2007). P2X7 receptor activation causes phosphatidylserine exposure in human erythrocytes. Biochemical and Biophysical Research Communications, 355 169-173 ...
P edseda poslaneck ho klubu ANO Jaroslav Falt nek z ejm p t rok nebude na sn mu obhajovat funkci prvn ho m stop edsedy hnut . Po sch zce s n m to televizi Nova ekl p edseda hnut a premi r Andrej Babi . D vodem je z ejm situace kolem brn nsk organizace ANO, kterou Falt nek zakl dal.
TMEM204兔多克隆抗体(ab113102)可与小鼠, 大鼠, 人样本反应并经WB, IHC, ICC, ICC/IF实验严格验证。所有产品均提供质保服务,中国75%以上现货。
In vitro PMA/ionomycin treatment for 5 h, which activates a signal transduction step down-stream of ZAP-70 and therefore equally activates SKG and BALB/c T cells, revealed that a significant fraction of LN CD4+ T cells from nonarthritic SKG mice in an SPF environment were producing IL-17A (hereafter IL-17), whereas SKG or BALB/c CD4-SP thymocytes or BALB/c CD4+ T cells were not (Fig. 1 A and Fig. S1, which is available at http://www.jem.org/cgi/content/full/jem.20062259/DC1). Such IL-17-producing SKG CD4+ T cells also produced at a single cell level TNF-α and IL-2, but not IFN-γ, IL-4, or IL-10, a profile distinct from Th1 or Th2 cells and similar to that of Th17 cells (Fig. 1 A; references 7-9). CD4+ T cells freshly prepared from nonarthritic SKG mice also actively transcribed IL-17 and IL-23R mRNA (Fig. 1 B). In arthritic SKG mice raised in a conventional environment, arthritic joints actively transcribed IL-17 mRNA, whereas nonarthritic ones did not (Fig. 1 C). Correspondingly, CD4+ T cells ...
w00t! after 6 long weeks my emag has returned from ano! I could not be happier with the finish :D Enough chit-chat... PICTURES! Before: http://i1046.photobucket.com/albums/b461/sQuid-Vision/0F07329E-3CBC-41F4-B2CF-A4E8531CA79B-7719-0000081BE189A8F7.jpg Broken Down for Ano:
COMUNICAÇÕES APRESENTADAS EM CONGRESSOS INTERNACIONAIS As Comunicações estão organizadas em duas partes. A primeira compreende o período de 1976-1995 e, no segundo, temos informações apresentadas, ano a ano, a partir de 1996.. ...
Unregulated increases in cellular Ca2+ homeostasis are a hallmark of pathophysiological conditions and a key trigger of cell death. Endothelial cells cultured under physiologic O2 conditions (5% O2) exhibit a reduced cytosolic Ca2+ response to stimulation. The mechanism for reduced plateau [Ca2+]i upon stimulation was due to increased sarco/endoplasmic reticulum Ca2+ ATPase (SERCA)-mediated reuptake rather than changes in Ca2+ influx capacity. Agonist-stimulated phosphorylation of the SERCA regulatory protein phospholamban was increased in cells cultured under 5% O2 Elevation of cytosolic and mitochondrial [Ca2+] and cell death after prolonged ionomycin treatment, as a model of Ca2+ overload, were lower when cells were cultured long-term under 5% compared with 18% O2 This protection was abolished by cotreatment with the SERCA inhibitor cyclopiazonic acid ...
The lack of understanding of AERD and its underlying cause has created a critical barrier in developing effective treatments for the condition. "Many practitioners are unaware of AERD and this is often why it takes so long to connect all the pieces of the puzzle before the correct treatment can be offered," Dr. Jerschow said.. Additionally, the very act of diagnosing AERD is risky, since many patients will suffer an asthma attack in response to the standard oral-graded aspirin challenge. Dr. Jerschows study will compare the pharmacological effects (biochemical changes in the body) of aspirin in AERD patients to those of aspirin-tolerant asthmatics. Her protocol, conducted on 25-30 participants aged 25-62 (some of whom are referred by the Department of Otorhinolaryngology - Head & Neck Surgery), will use a low-dose aspirin challenge to avoid allergic reactions. The low-dose aspirin challenge begins by giving the patient a small amount of aspirin. This approach usually does not lead to a ...
Recombinant Human DPY30 protein is an Escherichia coli Full length protein 2 to 99 aa range, |=85% purity and validated in SDS-PAGE.
Besides their use in inflammatory lung diseases the novel bisphosphonates with prolonged carbon chain may be used as treatment option for cystic fibrosis and atherosclerosis.,br,,br, ,b,Benefits:,/b,,br, ,ul, ,li,Neutral sphingomyelinase is not influenced,/li, ,li,First ex-vivo data in a PAF-induced edema rat model showed clear edema reduction by 50percent,/li, ,li,Inhibition of dexamethasone induced apoptosis was proven ,em,in vitro,/em,,/li, ,li,Substances can easily be synthesized in a one-step or two-step procedure,/li, ,li,Prolongation from 6 to 8 C-atoms shows 40times higher inhibition rate,/li, ,/ul, ,p,,strong,IP Rights,/strong,,br, EP Application (08/2009).,br, PCT Application (08/2010). ,br, A PCT application was filed in August 2010.,br, ,br, ,strong,Patent Owner,/strong,,br, Humboldt-Universität zu Berlin,br, Rheinisch-Westfälische,br, Technische Hochschule Aachen (RWTH),br,,br, ,b,Find the technology offer and contact details here: ,a ...
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Fenstein, MB; Fraser, C (1975). "Human platelet secretion and aggregation induced by calcium ionophores. Inhibition by PGE1 and ... IP receptors bind with ionophores that induce ADP and serotonin secretion. PGE1 inhibits the secretion of factors that ... 5-triphosphate signaling and the mobilization of calcium inside the cell for thromboxane A2. PGI2, prostacyclin, binds to IP ...
... however others have found it necessary to also use calcium ionophore treatment for fertilisation to be successful. Calcium ... "Mechanism of action of calcium ionophores on intact cells: ionophore-resistant cells". Membrane & Cell Biology. 13 (3): 357-368 ... It has been found that treating globozoospermia with ICSI along with oocyte activation by calcium ionophore (an ion carrier ... "A Successful Healthy Childbirth in a Case of Total Globozoospermia with Oocyte Activation by Calcium Ionophore". Journal of ...
... and calcium ionophore-induced arachidonic acid release". J. Biol. Chem. 278 (40): 38206-13. doi:10.1074/jbc.M304816200. PMID ... CERK was later confirmed to bind calmodulin in the presence of calcium, indicating the calmodulin first binds calcium and then ... A calcium-stimulated lipid kinase that co-purifies with brain synaptic vesicles". J. Biol. Chem. 264 (24): 14354-60. PMID ... CERK has also been found to participate in the calcium-dependent degranulation of mast cells. Sugiura M, Kono K, Liu H, ...
Asaga H, Yamada M, Senshu T (February 1998). "Selective deimination of vimentin in calcium ionophore-induced apoptosis of mouse ...
Calcium Ionophore, Antibiotic A23187 and Calcium Ionophore A23187. It is produced at fermentation of Streptomyces ... The ionophore is used in laboratories to increase intracellular Ca2+ levels in intact cells. It also uncouples oxidative ... It also acts as a divalent cation ionophore, allowing these ions to cross cell membranes, which are usually impermeable to them ... of Topotecan Enhances Anticancer Efficacy in Murine and Human Xenograft Models Cancer Research Effect of calcium ionophore on ...
ARE-directed mRNA degradation is influenced by many exogenous factors, including phorbol esters, calcium ionophores, cytokines ...
Reiss, Hans-Dieter; Herth, Werner (1979). "Calcium ionophore A 23187 affects localized wall secretion infqu hoeegion of pollen ...
Interference from calcium, magnesium, or lithium, on the other hand, is weak enough that their presence in normal ... These electrodes are typical ion exchange resin membrane electrodes, using valinomycin, a potassium ionophore, as the ion ... calcium, magnesium, and lithium. The most significant interference with measurement of potassium concentration is from the ...
... is an ionophore produced by the bacterium Streptomyces conglobatus. It is used in research to raise the intracellular ... See Ionomycin Calcium salt Archived 2006-06-26 at the Wayback Machine. from Fermentek, manufacturer's product page for ... level of calcium (Ca2+) and as a research tool to understand Ca2+ transport across biological membranes. It is also used to ...
"Epidermal growth factor induces p11 gene and protein expression and down-regulates calcium ionophore-induced arachidonic acid ... "Epidermal growth factor induces p11 gene and protein expression and down-regulates calcium ionophore-induced arachidonic acid ... S100 calcium-binding protein A10 (S100A10), also known as p11, is a protein that is encoded by the S100A10 gene in humans and ... Wu T, Angus CW, Yao XL, Logun C, Shelhamer JH (Jul 1997). "P11, a unique member of the S100 family of calcium-binding proteins ...
The anergy in T cells can be induced by Ionomycin, the ionophore capable of raising intracellular concentration of calcium ions ... Conversely, Ca+II chelators such as EGTA can sequester Calcium ions making them unable to cause the anergy. Blocking of the ... Under this condition, calcium dependent phosphatase calcineurin removes phosphates from a transcriptional factor NFAT, which in ... On the contrary, TCR signalling without costimulatory receptors sufficiently activates only the calcium arm of the signalling ...
... may be artificially facilitated by calcium ionophores, something that is speculated to be useful in case of ... The slow block is through a biochemical mechanism triggered by a wave of calcium increase. The rise of calcium is both ... "Roscovitine in combination with calcium ionophore induces oocyte activation through reduction of M-phase promoting factor ... Sperm entry causes calcium release into the oocyte. In mammals, this has been proposed to be caused by the introduction of ...
A23187 (Calcimycin, Calcium Ionophore). *Abamectin Abamectin. *Aigéad aibiteach Abietic acid. *Aigéad aicéiteach Acetic acid ...
Sperm activation has been shown to be caused by calcium ionophores in vitro, progesterone released by nearby cumulus cells and ... The opening of CatSper channels is responsible for the influx of calcium. The sudden rise in calcium levels causes the ... A recent discovery links hyperactivation to a sudden influx of calcium ion into the tails. The whip-like tail (flagellum) of ... These channels are selective, allowing only calcium ions to pass. ...
"Design and Synthesis of Calcium and Magnesium Ionophores Based on Double-Armed Diazacrown Ether Compounds and Their Application ... Ionophores such as valinomycin also display a marked preference for the potassium cation over other cations. In 1967, Charles ... and 18-membered diazacrown ether derivatives exhibit excellent calcium and magnesium selectivities and are widely used in ion- ...
... slow and inert in the reproductive tracts or storage areas of the female and are only activated by calcium ionophores in vitro ...
PCP-2 mRNA is regulated by phorbol myristate acetate (PMA) or calcium ionophore, okadaic acid, the Ras inhibitor manumycin, and ... down-regulation of gene expression by PMA and calcium ionophore in Jurkat T lymphoma cells". Biochem Biophys Res Commun. 231 (1 ...
... such as calcium ionophore treatment, microinjection of calcium ions, or electrical stimulation. Treatment with cycloheximide, a ... The fertilization event causes intracellular calcium oscillations, and targeted degradation of cyclin B, a regulatory subunit ...
... calcium channel agonists MeSH D27.505.519.562.249 --- calcium channel blockers MeSH D27.505.519.562.374 --- ionophores MeSH ... calcium channel agonists MeSH D27.505.954.411.793.610 --- nasal decongestants MeSH D27.505.954.411.918 --- vasodilator agents ... calcium channel blockers MeSH D27.505.954.411.207 --- cardioplegic solutions MeSH D27.505.954.411.222 --- cardiotonic agents ...
... as well as the more commonly used calcium ionophore A23187. Birefringence microscopy, flow cytometry or fluorescence microscopy ... Once the two meet, a calcium influx occurs, causing a signaling cascade. The cortical granules inside the oocyte then fuse to ...
... down-regulation of gene expression by PMA and calcium ionophore in Jurkat T lymphoma cells". Biochemical and Biophysical ... Flentke GR, Garic A, Amberger E, Hernandez M, Smith SM (July 2011). "Calcium-mediated repression of β-catenin and its ... Soluble inositol-(1,4,5)-trisphosphate triggers calcium to be released from the endoplasmic reticulum. This sudden increase in ... "Modification of the composition of polycystin-1 multiprotein complexes by calcium and tyrosine phosphorylation". Biochimica et ...
... and a lipid-soluble molecule that transports calcium ions (Ca2+) across the bilayer, also known as calcium ionophore. C1P was ... Inside the cell, S1P can induce calcium release independent of the S1PRs-the mechanism of which remains unknown. To date, the ... Tornquist, K. (February 2003). "Ceramide-1-phosphate increases intracellular free calcium concentrations in thyroid FRTL-5 ... and increase intracellular free calcium concentrations in thyroid cells. C1P also has known roles in vesicular trafficking, ...
... as well as the more commonly used calcium ionophore A23187. This can be done to serve as a positive control when assessing the ...
... of agents such as the chelator EGTA and the ionophore A23187 could have been incorrectly said to be specific for calcium in ... The traditional supply of calcium salts to fungal cultures may have met the need for trace elements as even A.R. calcium salts ... In the experiments with oxygen and hyphal development there was no requirement for calcium and no inhibition by EGTA. At the ... time of these studies many mycologists thought that calcium played a role in fungal morphology and were disinclined to believe ...
... greatly overproduce 15-hydroxyicosatetraenoic acid and eoxin C4 when challenged with arachidonic acid or calcium ionophore ...
Calcium Scandium Titanium Vanadium Chromium Manganese Iron Cobalt Nickel Copper Zinc Gallium Germanium Arsenic Selenium Bromine ... carbohydrates and ionophore complexes.[218] ... calcium (1.5%), and aluminium (1.4%); with the remaining 1.2% ... Similar solutions are formed by the heavy divalent alkaline earth metals calcium, strontium, barium, as well as the divalent ... with calcium chloride typically added to lower the melting point of the mixture. The heavier alkali metals, however, is more ...
Calcium Ionophore A23187 hemimagnesium salt for your research needs. Find product specific information including CAS, MSDS, ... Biochemicals and Reagents, Calcium Ionophores, Calcium Signaling Research Tools, Cell Biology, Cell Signaling and Neuroscience ... Calcium Ionophore A23187 hemimagnesium salt Synonym: A23187 hemimagnesium salt, Antibiotic A 23187 hemimagnesium salt, ... Interferes with Cell Membrane Permeability (Ionophores), Intracellular Calcium Signaling, Mechanism of Action, Spectrum of ...
Effect of calcium ionophores on early development in fucoid algae * * Hable Whitney E. HABLE Whitney E. ... Calcium buffer injections block fucoid egg development by facilitating calcium diffusion SPEKSNIJDER J. E. ... Pollen tube growth is coupled to the extracellular calcium ion flux and the intracellular calcium gradient:effect of BAPTA-type ... Pollen tube growth and the intracellular cytosolic calcium gradient oscillate in phase whike extracellular calcium influx is ...
Calcium ionophore IV , C52H100N2O3 , CID 601910 - structure, chemical names, physical and chemical properties, classification, ...
Calcium, Dietary. Ionophores. Calcium Ionophores. Bone Density Conservation Agents. Physiological Effects of Drugs. Membrane ... Drug: Ca Ionophore A23187 Sibling oocytes are to be randomized to artificially activated using Calcium ionophore in cases with ... Experimental: Ca ionophore Artificial activation of the oocytes using Calcium ionophore in the cases of severe male factor ... Can Calcium Ionophore Application Enhance the ICSI Outcomes in Severe Male Factor Infertility?. The safety and scientific ...
Inhibition of calcium ionophore (A23187) stimulated LTB4 formation in human neutrophils. ...
The effects of the calcium inonophore A 23187 on growing pollen tubes of Lilium longiflorumThunb. cv. Ace were investigated ... Borle, A.B., Studer, R.: Effects of calcium ionophores on the transport and distribution of calcium, in isolated cells and in ... Foreman, J.C., Mongar, J.L., Gomperts, B.D.: Calcium ionophores and movement of calcium ions following the physiological ... Calcium ionophore A 23187 affects localized wall secretion in the tip region of pollen tubes of Lilium longiflorum. ...
Calcium ionophore solution increase on going pregnancy rate [ Time Frame: up to 21 weeks ]. İf the calcium ionophore can ... Calcium, Dietary. Ionophores. Ionomycin. Calcium Ionophores. Bone Density Conservation Agents. Physiological Effects of Drugs. ... calcium ionophore can decrease fertilization rate [ Time Frame: 18 hours ]. To detect if calcium ionophore can affect ... Experimental: calcium ionophore the patients whose oocytes are incubated with calcium ionophore solution during ICSI cycle ...
Oral-aboral ectoderm differentiation of sea urchin embryos is disrupted in response to calcium ionophore * * Akasaka Koji ...
Endothelium dependence of dilation of pial arterioles in mouse brain by calcium ionophore.. W I Rosenblum, G H Nelson ... We used calcium ionophore A-23187, another dilating agent known from in vitro studies of large arteries to be endothelium- ... Endothelium dependence of dilation of pial arterioles in mouse brain by calcium ionophore. ... Endothelium dependence of dilation of pial arterioles in mouse brain by calcium ionophore. ...
Calcium ionophore A23187 (188 ng/ml) was added to respective wells 48 h later. After a total 96-h culture period, cells were ... In the studies presented here we show that under serum-free conditions, LPS, TNF-α, and calcium ionophore (CI) A23187 are each ... 3 Abbreviations used in this paper: DC, dendritic cell; CI, calcium ionophore; CsA, cyclosporin A; Mφ-SFM, macrophage serum- ... Calcium ionophore-treated peripheral blood monocytes and dendritic cells rapidly display characteristics of activated dendritic ...
Human whole blood was stimulated with calcium ionophore (A23187) and LTB 4 measured by enzyme immunoassay. ...
BioAssay record AID 131935 submitted by ChEMBL: Tested for its antiinflammatory activity in the A-23187 (calcium ionophore) ear edema model..
An Ionophore for Calcium Ions and the Stimulation of Histamine Secretion from Rat Peritoneal Mast Cells J. C. FOREMAN; J. C. ... J. C. FOREMAN, B. D. GOMPERTS, J. L. MONGAR; An Ionophore for Calcium Ions and the Stimulation of Histamine Secretion from Rat ... Activation of (arachidonyl) phosphatidylinositol turnover in rabbit neutrophils by the calcium ionophore A23187 Biochem J ( ... Limits to the early increase in free cytoplasmic calcium concentration during the mitogenic stimulation of lymphocytes Biochem ...
Transactivation of the grp78 promoter by malfolded proteins, glycosylation block, and calcium ionophore is mediated through a ... Transactivation of the grp78 promoter by malfolded proteins, glycosylation block, and calcium ionophore is mediated through a ... Transactivation of the grp78 promoter by malfolded proteins, glycosylation block, and calcium ionophore is mediated through a ... Transactivation of the grp78 promoter by malfolded proteins, glycosylation block, and calcium ionophore is mediated through a ...
This induction requires a continuous presence of the ionophore for over 2 h. Although extracellular Ca2+ is important for the ... The calcium ionophore A23187 can reversibly induce the expression of two glucose-regulated genes, p3C5 and p4A3. ... Calcium ionophore A23187 as a regulator of gene expression in mammalian cells. @article{Resendez1986CalciumIA, title={Calcium ... A calcium ionophore-inducible cellular promoter is highly active and has enhancerlike properties.. *Albert Yu-Min Lin, Shu ...
Calcium ionophore synergizes with bacterial lipopolysaccharides in activating macrophage arachidonic acid metabolism. A A ... A A Aderem, Z A Cohn; Calcium ionophore synergizes with bacterial lipopolysaccharides in activating macrophage arachidonic acid ... The Ca2+ ionophore A23187 (0.1 microM) triggered the rapid release of 20:4 metabolites from LPS-primed macrophages but not from ...
Ionophore-resistant mutant of Toxoplasma gondii reveals involvement of a sodium/hydrogen exchanger in calcium regulation ... The calcium ionophore A23187 (Sigma-Aldrich) was dissolved in DMSO at 1 mM. DMA (Sigma-Aldrich) was dissolved in DMSO at 10 mM ... Toxoplasma gondii: calcium ionophore A23187-mediated exit of trophozoites from infected murine macrophages. Exp. Parasitol. ... Toxoplasma gondii: calcium ionophore A23187-mediated exit of trophozoites from infected murine macrophages. Exp. Parasitol. ...
416 Xenbase articles contain a reference to calcium ionophore according to textpresso ... Retrieved from "http://wiki.xenbase.org/xenwiki/index.php?title=Calcium_ionophore&oldid=43133" ...
... high quality calcium ionophore from Hello Bio, a trusted supplier for life science researchers worldwide ... Role of calcium ionophore A23187-induced activation of IkappaB kinase 2 in mast cells.. Hosokawa J et al (2013) Int Arch ... References for Calcium Ionophore A23187. *. Zn(2+), derived from cell preparation, partly attenuates Ca(2+)-dependent cell ... The following papers have cited the use of Calcium Ionophore A23187 (HB1000) from Hello Bio. If you have published a paper ...
Ebner T, Köster M, Shebl O, Moser M, Van der Ven H, Tews G, Montag M. Application of a ready-to-use calcium ionophore increases ... Darwish E, Magdi Y. A preliminary report of successful cleavage after calcium ionophore activation at ICSI in cases with ... Other: Ca2+ ionophore Ca2+ ionophore is a chemical agent used to perform oocyte activation after ICSI. It showed effective ... Effect of Ca2+ Ionophore on Embryonic Development and Clinical Outcome in Cases With Previous Fertilization Arrest. The safety ...
Category: Calcium Ionophore. Cachexia affects nearly all cancer sufferers, with currently zero effective remedies.. Posted on ... Posted in Calcium IonophoreTagged Rabbit Polyclonal to BAX, Risedronic acid (Actonel) supplier ... Posted in Calcium IonophoreTagged Rabbit Polyclonal to MART-1., SVT-40776 (Tarafenacin) ...
... and the calcium ionophore, ionomycin. T cells were rendered competent as the result of a 30-min initial incubation with both ... and the calcium ionophore, ionomycin. T cells were rendered competent as the result of a 30-min initial incubation with both ... and the calcium ionophore, ionomycin. T cells were rendered competent as the result of a 30-min initial incubation with both ... and the calcium ionophore, ionomycin. T cells were rendered competent as the result of a 30-min initial incubation with both ...
Calcium indicators and ionophores. Find the best indicator and ionophore for imaging Ca2+ and cell function. ... potassium and calcium. Join researchers worldwide and find ion channel modulators for your research. ...
... cultured in calcium ionophore A23187, and cultured in ionophore plus calpain inhibitor E64. Lenses were cultured for 7 days, ... cultured in calcium ionophore A23187, and cultured in ionophore plus calpain inhibitor E64. Lenses were cultured for 7 days, ... cultured in calcium ionophore A23187, and cultured in ionophore plus calpain inhibitor E64. Lenses were cultured for 7 days, ... cultured in calcium ionophore A23187, and cultured in ionophore plus calpain inhibitor E64. Lenses were cultured for 7 days, ...
Measurement of free cytosolic calcium concentration in single CHO-K1 cells 635805852410000000 ...
  • ARE-directed mRNA degradation is influenced by many exogenous factors, including phorbol esters, calcium ionophores, cytokines, and transcription inhibitors. (wikipedia.org)
  • Tumor promoters in conjunction with calcium ionophores mimic antigenic stimulation by reactivation of alloantigen-primed murine T lymphocytes. (bgu.ac.il)
  • The stimulation of PBMC by phorbol ester and calcium ionophore decreased the calcineurin activity both in patients with SLE and in healthy controls. (bmj.com)
  • The mechanism is demonstrated to include stimulation of the ATP-binding cassette transporter A1 with subsequent activation of the calcium/calmodulin-dependent protein kinase kinase and the AMP-activated protein kinase pathway. (ahajournals.org)
  • As we describe here, transformed lympho-blasts have whole cell chloride currents under conditions of stimulation by cAMP agonists, calcium ionophore, or hypotonicity which are quite similar to the aggregate chloride currents measured under similar conditions in epithelial cells. (springer.com)
  • Furthermore, both T and B cells lacking RelA showed marked reduction in proliferative responses to stimulation with Con A, anti-CD3, anti-CD3+anti-CD28, LPS, anti-IgM, and PMA+calcium ionophore. (rupress.org)
  • The relationship of calcium to receptor-controlled stimulation of phosphatidylinositol turnover. (biochemj.org)
  • We find that calcium and kinase signaling cooperate to induce chromatin remodeling at ∼2100 chromatin regions, which demonstrate enriched binding motifs for inducible factors and correlate with target gene expression. (jimmunol.org)
  • It would explain both the excess of muscular constituents found in serum of patients and carriers, such as creatine kinase (CK), as well as the excessive calcium uptake by dystrophic muscle fibres, which, prior to necrosis, could lead to hypercontraction, rupture of myofilaments in adjacent sarcomeres and by excessive Ca uptake to mitochondrial damage causing crucial energy loss. (springer.com)
  • Partial activation of Fucus eggs with calcium onophores and low-sodium seawater. (nii.ac.jp)
  • Ion channels may be a site of action for fast acting neurotransmitters such as GABA, with popular channels include sodium, potassium and calcium. (abcam.com)
  • This has lead to recommendations for baseline and post-treatment measurement of sodium, potassium, chloride, bicarbonate, calcium, phosphate, blood urea nitrogen, and creatinine in patients receiving oral sodium phosphate solution. (encyclopedia.com)
  • Conclusions We conclude that eNOS gene transfer to the adventitia alters vascular reactivity, as demonstrated by diminished contractile responses to phenylephrine and enhanced relaxations to calcium ionophore. (ahajournals.org)
  • F. A. Lattanzio, M. Fahim, R. Koos, M. Clark, and B. C. Pressman, The effects of prostaglandin release by ionophores on cardiovascular responses in the intact dog, Fed. (springer.com)
  • Nonactin is a member of a family of naturally occurring cyclic ionophores known as the macrotetrolide antibiotics. (wikipedia.org)
  • Brewbaker, J.L., Kwack, B.H.: The essential role of calcium ion in pollen germination and pollen tube growth. (springer.com)
  • The Role of Calcium in Signal Transduction Between the Cytoplasm and Nuclei. (routledge.com)
  • The effect of NMDA on local actin assembly was strongly attenuated by pretreatment with an actin stabilizing compound or by an antagonist of the calcium-dependent protein phosphatase calcineurin. (jneurosci.org)
  • Under this condition, calcium dependent phosphatase calcineurin removes phosphates from a transcriptional factor NFAT, which in turn translocates to the nucleus. (wikipedia.org)
  • To facilitate the study of signaling pathways involved in myeloid dendritic cell (DC) differentiation, we have developed a serum-free culture system in which human CD14 + peripheral blood monocytes differentiate rapidly in response to bacterial LPS, TNF-α, or calcium ionophore (CI). (jimmunol.org)
  • Small organic molecules that act as allosteric activators of the calcium sensing receptor (CaSR) in the PARATHYROID GLANDS and other tissues. (nih.gov)
  • The effects of the calcium inonophore A 23187 on growing pollen tubes of Lilium longiflorum Thunb. (springer.com)
  • N. T. deGuzman and B. C. Pressman, The inotropic effects of the calcium ionophore X-537A in the anesthetized dog, Circulation 44:1072 (1974). (springer.com)