A drug used to reduce hemorrhage in diabetic retinopathy.
Agents acting to arrest the flow of blood. Absorbable hemostatics arrest bleeding either by the formation of an artificial clot or by providing a mechanical matrix that facilitates clotting when applied directly to the bleeding surface. These agents function more at the capillary level and are not effective at stemming arterial or venous bleeding under any significant intravascular pressure.
The deformation and flow behavior of BLOOD and its elements i.e., PLASMA; ERYTHROCYTES; WHITE BLOOD CELLS; and BLOOD PLATELETS.
Benzenesulfonate derivative used as a systemic hemostatic.
The internal resistance of the BLOOD to shear forces. The in vitro measure of whole blood viscosity is of limited clinical utility because it bears little relationship to the actual viscosity within the circulation, but an increase in the viscosity of circulating blood can contribute to morbidity in patients suffering from disorders such as SICKLE CELL ANEMIA and POLYCYTHEMIA.
Disease of the RETINA as a complication of DIABETES MELLITUS. It is characterized by the progressive microvascular complications, such as ANEURYSM, interretinal EDEMA, and intraocular PATHOLOGIC NEOVASCULARIZATION.
The property of blood capillary ENDOTHELIUM that allows for the selective exchange of substances between the blood and surrounding tissues and through membranous barriers such as the BLOOD-AIR BARRIER; BLOOD-AQUEOUS BARRIER; BLOOD-BRAIN BARRIER; BLOOD-NERVE BARRIER; BLOOD-RETINAL BARRIER; and BLOOD-TESTIS BARRIER. Small lipid-soluble molecules such as carbon dioxide and oxygen move freely by diffusion. Water and water-soluble molecules cannot pass through the endothelial walls and are dependent on microscopic pores. These pores show narrow areas (TIGHT JUNCTIONS) which may limit large molecule movement.
Molecules or ions formed by the incomplete one-electron reduction of oxygen. These reactive oxygen intermediates include SINGLET OXYGEN; SUPEROXIDES; PEROXIDES; HYDROXYL RADICAL; and HYPOCHLOROUS ACID. They contribute to the microbicidal activity of PHAGOCYTES, regulation of signal transduction and gene expression, and the oxidative damage to NUCLEIC ACIDS; PROTEINS; and LIPIDS.
Single pavement layer of cells which line the luminal surface of the entire vascular system and regulate the transport of macromolecules and blood components.
A local anesthetic of the amide type now generally used for surface anesthesia. It is one of the most potent and toxic of the long-acting local anesthetics and its parenteral use is restricted to spinal anesthesia. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1006)
An antihyperlipoproteinemic agent and uricosuric agent.
Drugs used by veterinarians in the treatment of animal diseases. The veterinarian's pharmacological armamentarium is the counterpart of drugs treating human diseases, with dosage and administration adjusted to the size, weight, disease, and idiosyncrasies of the species. In the United States most drugs are subject to federal regulations with special reference to the safety of drugs and residues in edible animal products.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
A local anesthetic with rapid onset and long action, similar to BUPIVACAINE.
Drugs that block nerve conduction when applied locally to nerve tissue in appropriate concentrations. They act on any part of the nervous system and on every type of nerve fiber. In contact with a nerve trunk, these anesthetics can cause both sensory and motor paralysis in the innervated area. Their action is completely reversible. (From Gilman AG, et. al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed) Nearly all local anesthetics act by reducing the tendency of voltage-dependent sodium channels to activate.
Spectrophotometric techniques by which the absorption or emmision spectra of radiation from atoms are produced and analyzed.
A visual impairment characterized by the accumulation of fluid under the retina through a defect in the retinal pigment epithelium.
A physical misalignment of the upper (maxilla) and lower (mandibular) jaw bones in which either or both recede relative to the frontal plane of the forehead.
Disorders of the choroid including hereditary choroidal diseases, neoplasms, and other abnormalities of the vascular layer of the uvea.
Visualization of a vascular system after intravenous injection of a fluorescein solution. The images may be photographed or televised. It is used especially in studying the retinal and uveal vasculature.
Separation of the inner layers of the retina (neural retina) from the pigment epithelium. Retinal detachment occurs more commonly in men than in women, in eyes with degenerative myopia, in aging and in aphakia. It may occur after an uncomplicated cataract extraction, but it is seen more often if vitreous humor has been lost during surgery. (Dorland, 27th ed; Newell, Ophthalmology: Principles and Concepts, 7th ed, p310-12).
Lists of persons or organizations, systematically arranged, usually in alphabetic or classed order, giving address, affiliations, etc., for individuals, and giving address, officers, functions, and similar data for organizations. (ALA Glossary of Library and Information Science, 1983)
Drugs that act principally at one or more sites within the peripheral neuroeffector systems, the autonomic system, and motor nerve-skeletal system. (From Smith and Reynard, Textbook of Pharmacology, 1991, p75)
The duct which coveys URINE from the pelvis of the KIDNEY through the URETERS, BLADDER, and URETHRA.
Pathological processes of the URINARY TRACT in both males and females.
A country spanning from central Asia to the Pacific Ocean.
Drugs used for their effects on the respiratory system.
One of a pair of thick-walled tubes that transports urine from the KIDNEY PELVIS to the URINARY BLADDER.
A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE.
An anti-inflammatory 9-fluoro-glucocorticoid.
A constituent of STRIATED MUSCLE and LIVER. It is an amino acid derivative and an essential cofactor for fatty acid metabolism.
A bilateral retinopathy occurring in premature infants treated with excessively high concentrations of oxygen, characterized by vascular dilatation, proliferation, and tortuosity, edema, and retinal detachment, with ultimate conversion of the retina into a fibrous mass that can be seen as a dense retrolental membrane. Usually growth of the eye is arrested and may result in microophthalmia, and blindness may occur. (Dorland, 27th ed)
The blood vessels which supply and drain the RETINA.
Formation of new blood vessels originating from the retinal veins and extending along the inner (vitreal) surface of the retina.
A subtype of DIABETES MELLITUS that is characterized by INSULIN deficiency. It is manifested by the sudden onset of severe HYPERGLYCEMIA, rapid progression to DIABETIC KETOACIDOSIS, and DEATH unless treated with insulin. The disease may occur at any age, but is most common in childhood or adolescence.
Positively charged particles composed of two protons and two NEUTRONS, i.e. equivalent to HELIUM nuclei, which are emitted during disintegration of heavy ISOTOPES. Alpha rays have very strong ionizing power, but weak penetrability.
Atomic species differing in mass number but having the same atomic number. (Grant & Hackh's Chemical Dictionary, 5th ed)
Electrically neutral elementary particles found in all atomic nuclei except light hydrogen; the mass is equal to that of the proton and electron combined and they are unstable when isolated from the nucleus, undergoing beta decay. Slow, thermal, epithermal, and fast neutrons refer to the energy levels with which the neutrons are ejected from heavier nuclei during their decay.
Techniques for labeling a substance with a stable or radioactive isotope. It is not used for articles involving labeled substances unless the methods of labeling are substantively discussed. Tracers that may be labeled include chemical substances, cells, or microorganisms.
Actinium. A trivalent radioactive element and the prototypical member of the actinide family. It has the atomic symbol Ac, atomic number 89, and atomic weight 227.0278. Its principal isotope is 227 and decays primarily by beta-emission.
Stable nitrogen atoms that have the same atomic number as the element nitrogen, but differ in atomic weight. N-15 is a stable nitrogen isotope.
Signal transduction mechanisms whereby calcium mobilization (from outside the cell or from intracellular storage pools) to the cytoplasm is triggered by external stimuli. Calcium signals are often seen to propagate as waves, oscillations, spikes, sparks, or puffs. The calcium acts as an intracellular messenger by activating calcium-responsive proteins.

Calcium dobesilate potentiates endothelium-derived hyperpolarizing factor-mediated relaxation of human penile resistance arteries. (1/16)

1 We have evaluated the participation of endothelium-derived hyperpolarizing factor (EDHF) in the endothelium-dependent relaxation of isolated human penile resistance arteries (HPRA) and human corpus cavernosum (HCC) strips. In addition, the effect of the angioprotective agent, calcium dobesilate (DOBE), on the endothelium-dependent relaxation of these tissues was investigated. 2 Combined inhibition of nitric oxide synthase (NOS) and cyclooxygenase (COX) nearly abolished the endothelium-dependent relaxation to acetylcholine (ACh) in HCC, while 60% relaxation of HPRA was observed under these conditions. Endothelium-dependent relaxation of HPRA resistant to NOS and COX inhibition was prevented by raising the extracellular concentration of K(+) (35 mM) or by blocking Ca(2)(+)-activated K(+) channels, with apamin (APA; 100 nM) and charybdotoxin (CTX; 100 nM), suggesting the involvement of EDHF in these responses. 3 Endothelium-dependent relaxation to ACh was markedly enhanced by DOBE (10 micro M) in HPRA but not in HCC. The potentiating effects of DOBE on ACh-induced responses in HPRA, remained after NOS and COX inhibition, were reduced by inhibition of cytochrome P450 oxygenase with miconazole (0.3 mM) and were abolished by high K(+) or a combination of APA and CTX. 4 In vivo, DOBE (10 mg kg(-1) i.v.) significantly potentiated the erectile responses to cavernosal nerve stimulation in male rats. 5 EDHF plays an important role in the endothelium-dependent relaxation of HPRA but not in HCC. DOBE significantly improves endothelium-dependent relaxation of HPRA mediated by EDHF and potentiates erectile responses in vivo. Thus, EDHF becomes a new therapeutic target for the treatment of erectile dysfunction (ED) and DOBE could be considered a candidate for oral therapy for ED.  (+info)

A randomized, double-blind multicentre clinical trial comparing the efficacy of calcium dobesilate with placebo in the treatment of chronic venous disease. (2/16)

OBJECTIVE: To assess the efficacy of calcium dobesilate on the quality-of-life (QoL) of patients with chronic venous disease (CVD). DESIGN: Randomised, parallel, double blind, placebo-controlled clinical trial. METHODS: Patients were recruited from vascular surgery clinics and randomised to 500mg capsules of calcium dobesilate twice a day for 3 months or placebo. The primary outcome measure was 'QoL after 3 months' treatment measured by the specific Chronic Insufficiency Venous International Questionnaire (CIVIQ). Secondary outcomes were QoL at 12 months and assessment of the CVD signs and symptoms. The principal analysis was undertaken on the intention-to-treat (ITT) data. RESULTS: Five hundred and nine patients were recruited (246 to calcium dobesilate and 263 to placebo). The analysis of the 'QoL after 3 months' showed no significant differences between groups (p=0.07). For secondary outcomes, oedema and symptoms of CVD, there were no significant differences between groups. In a multi-factorial analysis, the 'QoL at 12 months' was better in the calcium dobesilate group than in placebo group (p=0.02). CONCLUSIONS: Treatment with calcium dobesilate was not found to be superior to placebo on the QoL of CVD patients. The sustained effect of calcium dobesilate observed after treatment should be confirmed in future studies.  (+info)

Reduced intimal hyperplasia in rabbits via medical therapy after carotid venous bypass. (3/16)

Intimal hyperplasia is a major cause of restenosis after the interventional or surgical treatment of occlusive arterial disease. We investigated the effects of clopidogrel, calcium dobesilate, nebivolol, and atorvastatin on the development of intimal hyperplasia in rabbits after carotid venous bypass surgery. We divided 40 male New Zealand rabbits into 4 study groups and 1 control group. After occluding the carotid arteries of the rabbits, we constructed jugular venous grafts between the proximal and the distal segments of the occluded artery. Thereafter, group 1 (control) received no medication. We administered daily oral doses of clopidogrel to group 2, calcium dobesilate to group 3, nebivolol to group 4, and atorvastatin to group 5. The rabbits were killed 28 days postoperatively. The arterialized jugular venous grafts were extracted for histopathologic examination. Intimal thicknesses were 42.87 +/- 6.95 microm (group 2), 46.5 +/- 9.02 microm (group 3), 34.12 +/- 5.64 microm (group 4), and 48.37 +/- 6.16 microm (group 5), all significantly less than the 95.12 +/- 9.93 microm in group 1 (all P < 0.001). Medial thicknesses were 94 +/- 6 microm (group 2), 101.5 +/- 13.52 microm (group 3), 90.5 +/- 9.69 microm (group 4), and 101.37 +/- 7.99 microm (group 5), all significantly thinner than the 126.62 +/- 13.53 microm in group 1 (all P < 0.001). In our experimental model of carotid venous bypass grafting in rabbits, clopidogrel, calcium dobesilate, nebivolol, and atorvastatin each effectively reduced the development of intimal hyperplasia. Herein, we discuss our findings and review the medical literature.  (+info)

Calcium dobesilate inhibits the alterations in tight junction proteins and leukocyte adhesion to retinal endothelial cells induced by diabetes. (4/16)

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Detecting treatment response in a model of human breast adenocarcinoma using hyperpolarised [1-13C]pyruvate and [1,4-13C2]fumarate. (5/16)

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Modulation of the intramedullary pressure responses by calcium dobesilate in a rabbit knee model of osteoarthritis. (6/16)

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Hemorrhoids: from basic pathophysiology to clinical management. (7/16)

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Topical dobesilate eye drops for ophthalmic primary pterygium. (8/16)

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76404-12-1 - XEJLOZIIJDYLQR-PNTPOIPESA-L - Calcium Dobesilate mixture with Dexamethasone and Lidocaine - Similar structures search, synonyms, formulas, resource links, and other chemical information.
To the best of the authors knowledge, the current study is the first to demonstrate that CaD inhibits changes in endothelial and inflammatory protein levels. Specifically, CaD significantly inhibited the expression of VEGF and VEGFR, which are known to mediate abnormal HUVEC proliferation (17). CaD also prevented the HG-induced increases in HUVEC migration and permeability, most likely by suppressing ICAM-1, PTX3 and MCP-1 expression.. CaD, an antioxidant and angioprotective agent, blocks the increase in capillary permeability induced by reactive oxygen species, enhances the activity of nitric oxide synthase in endothelial cells, and inhibits apoptosis and inflammatory cytokine expression in blood vessels and other tissues (18). CaD effectively treats diabetic retinopathy at the systemic and local ocular levels and is therefore widely used to treat this disorder (18). DKD and retinopathy often coexist, develop in parallel, and have similar pathogeneses (19). Zhang et al (13) observed that CaD ...
To report the anatomic and functional outcome of intravitreal dobesilate to treat recurrent central serous chorioretinopathy (CSC). This is an interventional case report in which dobesilate was intravitreally injected in a case of recurrent CSC
Diabetic nephropathy, a microvascular complication of diabetes, is a progressive kidney disease caused by angiopathy of the capillaries in the kidney glomeruli. Herein, we report a case of a 62-year-old patient with a 30 year history of diabetes, who showed a substantial improvement in diabetic nephropathy on administration of 30 g of Astragalus membranaceus extract per day. After 1 month, estimated glomerular filtration rate increased from 47 to 72 ml/min per 1.73 m2 and was subsequently maintained at the 1-month follow-up. Urinary protein levels also decreased following treatment. Herein, we present and discuss the evidence and mechanism of A. membranaceus on diabetic nephropathy in this patient. ...
Diabetic nephropathy, a microvascular complication of diabetes, is a progressive kidney disease caused by angiopathy of the capillaries in the kidney glomeruli. Herein, we report a case of a 62-year-old patient with a 30 year history of diabetes, who showed a substantial improvement in diabetic nephropathy on administration of 30 g of Astragalus membranaceus extract per day. After 1 month, estimated glomerular filtration rate increased from 47 to 72 ml/min per 1.73 m2 and was subsequently maintained at the 1-month follow-up. Urinary protein levels also decreased following treatment. Herein, we present and discuss the evidence and mechanism of A. membranaceus on diabetic nephropathy in this patient. ...
Dobesilate (2,5-dihydroxyphenyl sulfonate, DHPS) was recently identified as the most potent member of a family of fibroblast growth factor (FGF) inhibitors headed by gentisic acid, one of the main catabolites of aspirin. Although FGFs were first described as inducers of angiogenesis, they were soon recognized as broad spectrum mitogens. Furthermore, in the last decade these proteins have been shown to participate directly in the onset of inflammation, and their potential angiogenic activity often contributes to the inflammatory process in vivo. The aim of this work was to evaluate the anti-inflammatory, anti-angiogenic and anti-tumoral activities of the derivative of DHPS obtained by acetoxylation of its two hydroxyl groups (2,5-diacetoxyphenyl sulfonate; DAPS). Anti-inflammatory, anti-angiogenic and anti-tumoral activities of DHPS and DAPS were compared using in vivo assays of dermatitis, angiogenesis and tumorigenesis. The effects of both compounds on myeloperoxidase (MPO) and cyclooxygenase (COX)
Retinal, Disease, Risk, Risk Factors, Aged, Calcium, Treatment, Calcium Dobesilate, Diabetic Retinopathy, Role, Kinase, Protein Kinase, Cancer, Head, and Migration
Calcium, Administration, Blood, Blood Viscosity, Calcium Dobesilate, Capillary, Capillary Permeability, Drugs, Erythrocyte, Erythrocyte Aggregation, Filtration, Patients, Permeability, Platelet, Prostaglandins, Thromboxanes, Treatment, Venous Insufficiency, Viscosity, Work
The design for the SPINlab Diamond Polariser, based on the dissolution-dynamic nuclear polarisation technique (DNP)1, was first presented in 2010 by GE (GE Research Circle Technology, Inc.)2. SPINlab hyperpolarises MR-sensitive nuclei, such as 13C, increasing the MR signal by 10,000 to 100,000 fold. The conditions required for polarisation include high magnetic field (5 Tesla), a very low temperature (~1K), a radical or electroparamagnetic additive (EPA), and microwave irradiation. SPINlab can be linked to an automated control subsystem for sample analysis, the QC module. The current QC module is optimised for use with 13C-pyruvate. Hyperpolarised 13C-pyruvate can be used to image metabolic rates in tissue by measuring the flux of the hyperpolarised 13C label from the pyruvate into other metabolites.. ...
Hyperpolarised (13)C MRI can be used to generate metabolic images of the heart in vivo. However, there have been no similar studies performed in the isolated perfused heart. Therefore, the aim of this study was to develop a method for the creation of (13)C metabolite maps of the perfused rat heart and to demonstrate the technique in a study of acute and chronic myocardial infarction. Male Wistar rat hearts were isolated, perfused and imaged before and after occlusion of the left anterior descending (LAD) coronary artery, creating an acute infarct group. In addition, a chronic infarct group was generated from hearts which had their LAD coronary artery occluded in vivo. Four weeks later, hearts were excised, perfused and imaged to generate metabolic maps of infused pyruvate and its metabolites lactate and bicarbonate. Myocardial perfusion and energetics were assessed by first-pass perfusion imaging and (31)P MRS, respectively. In both acute and chronically infarcted hearts, perfusion was reduced to the
Functional lung assessment using hyperpolarised xenon gas magnetic resonance imaging. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
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For sulfoxides I-VIII, hyperpolarised 13C pyruvate responses are observed immediately upon shaking the sample with 3 bar p-H2 in a mu metal shield. Over the next 90 minute time period, the resulting 13C pyruvate signal enhancements all gradually decrease (see ESI†). In all cases, the major dihydride complex present in solution proved to be of type 3b. Similarly, the hydride signals corresponding to 3b type products dominate the associated hyperpolarised hydride region of these 1H NMR spectra, and the intensity of their signals also decrease with increasing reaction time. Increasing the structural complexity of the co-ligand through the use of amino acid derived sulfoxide, IX, resulted in no 13C pyruvate signal enhancement, or detection of signals for species of type 3. While a hydride containing complex forms, which yields resonances at δ −12.3 and δ −27.3 that exhibit weak PHIP enhancement upon shaking with p-H2 (see ESI†), no evidence of pyruvate coordination was found. The poor ...
Pyruvate is a commonly used substrate in hyperpolarised MRS studies due to its key location in a number of anabolic and catabolic transformations associated with in energy metabolism, see figure 1. Hyperpolarised dDNP has found major application in studying heart function and cancer of a range of tissues.. Under aerobic conditions functional mitochondria metabolises pyruvate to acetyl-CoA by oxidative phosphorylation. During anaerobic conditions pyruvate is fermented to lactate, which is catalysed by lactate dehydrogenase (Figure 1). Cancer cells often favour the lactate pathway even in the presence of oxygen (Warburg Effect). Therefore, methods for blocking this pathway have therapeutic potential.. In a CRUK funded project grant (CRUK project grant. C1276/A10345) at Sheffield we have been using dissolution DNP to study cancer metabolism. In a P22 fibrosarcoma tumour model we estimate the rate constant for pyruvate to lactate conversion in tumours in response to a hypoxic challenge, using ...
This is the first time researchers have demonstrated that this scanning technique, called carbon-13 hyperpolarised imaging, can be used to monitor breast
My interests are in the areas of Magnetic Resonanceand Physics at Low Temperatures. Currrent projects are Magnetic Resonance Imaging of the lungs using hyperpolarised He-3, solid state NMR at very low temperatures, Nanomechanical oscillators and lung mechanics. The MRI project is currently aimed at understanding lung development from childhood through adulthood with a study of the potential of the method to detect the early onset of lung disease. The behaviour of small mechanical oscillators is studied at very low temperaure. These can be made with dimensions of around thousandth of a millimeter and have great potential as sensors as well as allowing us to study quantum effects in macroscopic objects.. Current Teaching Fourth Year Project (F34APM), 4th year organiser, Postgraduate Tutor. ...
V dnešnej dobe majú interpreti ťažké preraziť - peniaze, mainstream, konkurencia. A to napriek tomu, že často ide o veľmi kvalitných muzikantov. Mnohí sa snažia hrať progresívne a pritom vôbec nevedia, čo znamená progresivita v hudbe. A ako to […]. ...
Isty cas sledujem problematiku okolo povinneho ockovania a tak isty cas uz popri tom sledujem aj Vase reakcie ci vystupenia v mediach. Pozrel som si aj vystupenie p. Petek o ockovani. Urobila na mna lepsi dojem nez Vy. Neviem ako to ozaj s ockovanim je, kto ma pravdu a kto nema. Vidim vsak do farmaceutickej masinerie viac nez iny. Vidim do toho ako sa organizuju kongresy pre lekarov, ktore su o wellness pobytoch, lyzovackach s az 2 hodinovym odbornym programom (aby pani lekari mali cas si pochutit na dobrom jedle, fitko, wellness, somelier, vecerny program so skupinou za 3500Eur) daroch pre ambulancie (tlaciarne, pocitace, chladnicky a v poslednej dobe aj peniaze), len aby predpisovali lieky danej farmaceutickej spolocnosti. Vsetko to sprostredkuvavaju reprezentanti farmaceutickych firiem a lekari neodmietaju, naopak ziadaju si to. Zdravie pacienta je na vedlajsie kolaji, choroba pacienta je zdroj zisku. Ked organizujeme nejaky kongres pre Vas lekarov, rad si vzdy prehliadnem parkovisko pred ...
Len prednedávnom vyšla najnovšia verzia Greenie Linux 2.0 s označením Gerfihellania, ktorá vychádza z obľúbenej distribúcie Ubuntu Gutsy. Za touto mladou distribúciou stojí jej kontroverzný zakladateľ a tvorca Stanislav Hoferek, ktorého určite viacerí poznajú aj z fóra na LinuxOS.sk. Keďže v poslednej dobe sa veľa diskutuje o tom, či má zmysel táto distribúcia ako aj o použiteľnosti zo strany bežného používateľa, rozhodol som sa Greenie Linux nainštalovať a vyskúšať.
Sú vaše vlasy veľmi poškodené a hľadáte niečo, čo by vám ich pomohlo naozaj hĺbkovo zregenerovať? Túžite mať rovný a uhladený účes? Potom vyskúšajte jedinečné účinky látky zvanej keratín, ktorá v poslednej dobe
Souhlasim s Luckou, clanek pani Kateriny je skutecne jen bezmyslenkovite odsouzeni, bez nejmensi snahy o spetku pochopeni. Ja se dvakrat v zivote panicky bala tehotenstvi, po kterem jsem jinak velice touzila. V dobe kdy mi bylo 18 az 20 a zila jsem s rodici a otec me tyral( a soucasne nenavidel ...
katkamarek aj ja tento mesiac idem na duph. prvy krat...tak uvidime...doktorka mi zistila, ze mam slabu sliznicu a vajiko by sa nemalo kde uhniezdit...povedala nech nasadim 11 den, ked som jej oponovala, ze co to nemoze bloknut ovulku, vajadrila sa, ze to nema vplyv na ovulaciu...no nedalo mi to a na druhy den som jej opat volala, ze ci naozaj to na ten 11 den mam zobrat, lebo pocas 9 mesiacov co si meriam BT som mala ovulaciu vzdy...tak mi povedala, ze nech dalej meriam, ze to tnto cyklus odsledujeme a ak by nahodou bloklo, tak to potom upravime, ale mam to zobrat na 11 den. Ako tebe doki kazal? na ktory den? ja ti poviem pravdu, ze nie som v tomto taka dobra ako baby co tu uz dlho pisu...ja som ani netusila, ze mozem mat slabu - hladku sliznicu...vsetko je pre mna nove...ja mam pravidelny cyklus 28 ale v poslednej dobe uz 4-5 dni pred spinim a mam mrchu 2-3 dni slabu, tak aj to by sa malo upravit. No tak naozaj clovek nevie co je dobre pokial to na sebe nezisti...ja ju posluchnem a ...
Tak nasťahovaní v podnájme milom malom útulnom. Po dobe hľadaní práce a pohovorov, po skúsenosti s prácou v kaderníctve som sa rozhodla hľadať niečo kreatívnejšie a pre mňa zábavnejšie a čo sa stalo? Našla som :) . Po zdĺhavom výberovom konaní, po troch kolách na pohovoroch som módna poradkyňa v Promod. Je to milá elegantne jednoduchá francúzska značka a po mojom Topshop ♥ jej snáď prídem na chuť. Teším sa na skúsenosť s touto prácou. Mám od nich pár kúskov a musím povedať, že kvalita a štýl tejto značke nechýba :) tak ľudia EnJoy ...
Zobrazit popis. BARNYS je pôvodný kanadská spoločnosť, ktorá v SR pôsobí od roku 1997 prostredníctvom divízie biopoľa GN. Až do roku 2004 všetku produkciu predávali pod značkou Proenzi a je dodnes známe, že v tej dobe to bola najviac rešpektovaná značka v danom segmente. Od roku 2004 sa naplno začali venovať produktovej rade Barny . V súčasnosti taktiež spolupracujú na vývoji a výrobe nutraceutík s medzinárodnou farmaceutickou spoločnosťou, ich dodávatelia a finálne výrobky musia spĺňať farmaceutický štandard a farmaceutickú normu GMP.. ...
1 Answer - Posted in: etodolac, tramadol, medication - Answer: Hi, they are both analgesics, but they work very differently. Tramadol is ...
To develop techniques with MRI of Helium-3 gas to give functional images of the lungs. The goal is to test a single breath-hold functional 3-He MRI pulse sequence with sensitivity to multiple functional aspects of the luncg physiology. A group of 20 healthy volunteers willbe recruited from the local research group and the results compared with existing methods that require seperate breath-holds of 3He ...
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Popis Advantix Spot-on pre psy do 4 kg (4 pipety) 4x0,4 ml: Prípravok je určený pre psov, ktorí vážia do 4 kg. Je určený pre liečbu a prevenciu napadnutia blchami (C.felis, C.canis) a na liečbu napadnutia švolami (Trichodectes canis). Blchy na psoch hynú v priebehu jedného dňa po aplikácii. Jedno ošetrenie ochráni pred ďalším napadnutím blchami 4 týždňe. Liek sa môže použiť ako súčasť terapie alergickej dermatitídy vyvolanej blchami (FAD). Liek má perzistentný akaricídny a repelentný účinok proti napadnutiu kliešťami (Rhipicepalus sanguineus a Ixodes ricinus po dobu 4 týždńov a Dermacentor reticularis po dobu 3 týždňov. Kliešte prítomné na psovi v dobe aplikácie nemusia byť usmrtené počas 2 dní po liečbe a môžu ostávať prichytené a viditeľné. Preto sa odporúča odstrániť kliešte prítomné na psovi v dobe aplikácie, aby sa zabránilo ich prichyteniu a cicaniu krvi. Jednorazová aplikácie poskytuje repelentný (anti-feeding)
At the moment of ovulation there is a definite shift in the electrical fields of the body of a woman. The membrane in the follicle bursts and the egg passes down the Fallopian tube. The sperm is negative with respect to the egg. When the sperm and egg unite, the membrane around the egg becomes hyperpolarised, shutting out other sperm. It is at this moment that the electromagnetic entity is formed. The fertilized egg cell contains all the holistic information necessary to create a complete, operational, human being. The biohologram begins to function at conception and ceases only at death. Our contention is that the DNA at the centre of each cell creates the multi-cellular creature hologram by expressing and projecting the DNA in the centre of the cells ...
I dont keep my dogs intact for hormonal purposes in regards to sports. Please also remember that basic personality traits and hormones do not necessarily go hand in hand. A naturally fiesty dog is always going to be that way regardless of whether or not its surgically altered. I do have concerns about growth plate closure and long bone growth. Studies have shown that earlier spaying and neutering affect that. Having worked in the veterinary field for a very long time and also working with rescue animals for almost as long I can say that I can see a huge difference between early spay/neutered animals and those done later in life. There are visible effects on their growth develpment. This is why I chose to have it done later in life. Yes, plenty of intact male dogs end up with protatitis, anal tumors etc. but I have to say that Ive seen just as many neutered males with the same issues. Management of my intact males is not an issue so to me so I simply leave them intact. My Dobe had to ...
Za uvod poljubčki kalamarov, pri čemer kalamarčke polnijo s 16 mesecev zorjenim sirom provalone in rikoto, jim dodajo koščke sezonske zelenjave, vse skupaj pa zalijejo s kremno juho rumene paprike. Sledi eden od kreativnih vrhuncev hiše Don Alfonso - rezanci iz šipka, pospremljeni z jeguljinim sladoledom, kaviarjem jesetra in salso verde. Livia sladoledu vzhičeno pravi kar sladoled čustev, mi smo samo zaploskali ob intenzivnosti okusov. Naslednja jed je pripravljena po skoraj 400 let starem receptu iz burbonske dobe - klobasica iz ribona, mocarele in koromača s čipsom iz bučk in kremo iz sira provalone. Sledi klasika restavracij višjega ranga - reinterpretacija jajca. Pri Alfonsu uporabijo rumenjak svojega biološkega jajca, ga poširajo na 62 stopinj, nato pa postrežejo na krompirjevi peni z buratto, pod katero je plasti stročjega fižola (ali belušev, odvisno od sezone), nad njo pa rezine sveže naribanega črnega tartufa.. Sledita dve testeninski jedi: najprej z dušenim ...
V priebehu života sa môže stať, že Vaše vlasové korienky produkujú stále tenšie vlasy. Často je problém v pokožke hlavy, alebo v chýbajúcich výživných látkach. Ale tiež hormonálne výkyvy - predovšetkým klimaktérium - môžu spôsobiť, že sú vlasy stále tenšie. Keď si všimnete, že Váš účes drží stále horšie, vlasy sa Vám stále viac lámu, máte rozstrapkané končeky vlasov, vyhľadajte Hair Active Expert-a. Ten Vám bude odporúčať v krátkej dobe správne ošetrenia. Hair Active Expert okamžite zistí, či je problémom pokožka hlavy, alebo Vám chýbajú výživné látky, alebo oboje.. Je dôležité si uvedomiť, že tenké vlasy nie sú Vašim nezvrátiteľným osudom. Správnou metódou ošetrovania vlasov môžete už za niekoľko mesiacov aktivovať rast Vašich vlasov.. Difúzne vypadávanie vlasov /difúzna alopécia, telogenes Effluvium/. Najčastejšou formou vypadávania vlasov u žien je „difúzne vypadávanie vlasov. To znamená, ...
Už viac ako 10 rokov je v praxi zavedený systematický screening vaginálnej kolonizácie Streptococcus agalactiae (SAG, tiež GBS v anglickej literatúre) u tehotných v peripartálnom období. SAG patrí k jedným z najčastejších pôvodcov infekcií v novorodeneckom veku. K najzávažnejším komplikáciám infekcie spôsobenej SAG patrí meningitída a sepsa, ktoré sú aj v dnešnej dobe spojené s vysokou mierou úmrtnosti. Z hľadiska výskytu prvých príznakov infekcie sa rozlišuje včasná forma (EO - early onset, prvých 6 dní života) a neskorá forma (LO - late onset, 7-90 dní) [1, 13]. Výskyt komplikácií je častejší u nedonosených novorodencov, 23 % [2]; resp. 29-38 % [11], než u donosených 4 % [2]. Ku kolonizácií novorodenca dochádza pri prechode pôrodnými cestami v priebehu pôrodu, pretože SAG je pomerne častým patogénom prítomným vo vaginálnej a črevnej mikroflóre. Predpokladaný výskyt bezpríznakových prenášačov v populácii je asi tretina ...
The Faculty of Science was established in 1919. The faculty is founded on the tradition of Gregor Johann Mendel (1822-1884), the world-famous father of genetics. During the course of its existence, the faculty has successfully produced a number of prominent figures in biology, chemistry, geography, geology, physics and mathematics. To this day, it remains primarily a research-oriented faculty, offering university education closely linked to both primary and applied research and high school teaching of the following sciences: mathematics, physics, chemistry, biology and the Earth sciences.
Electrophysiological and microfluorometric measurements were combined to analyse the responses of rat striatal medium spiny (MS) and large aspiny (LA) interneurons to the mitochondrial uncoupler carbonyl cyanide p-trifluoromethoxyphenylidrazone (FCCP). FCCP produced a membrane depolarisation coupled to an irreversible increase in intracellular calcium [Ca2+]i in MS. Conversely, LA interneurons hyperpolarised and a moderate [Ca2+]i rise was observed. Cyclosporin A, inhibitor of the mitochondrial membrane transition pore, prevented the FCCP-induced changes in LA interneurons, whereas only a partial reduction was observed in MS cells. The present results indicate that mitochondrial Ca2+ released into the cytosol may contribute to the selective vulnerability to metabolic impairment in striatal neuronal subtypes.. ...
This protocol describes the investigation of the use of hyperpolarised helium magnetic resonance imaging (MRI) in reflecting the regional differences in lung function of moderate to severe Chronic Obstructive Pulmonary Disease (COPD) patients. Since finalisation of the original protocol, new medications for COPD have received Market Authorisation Approvals. Protocol Amendment 02 has been prepared to include these medications in the protocol eligibility criteria and restrictions for the study.
page) at the University of Southampton:. Position #1: Post-Doctoral Research Fellowship in nuclear magnetic resonance in the research group of Dr Giuseppe Pileio, in collaboration with Prof Malcolm H Levitt. The project, funded by EPSRC(UK), concerns the development of hardware and methodology that combines supercritical fluids with long-lived states NMR and dissolution-DNP to prolong the storage of hyperpolarised spin order and allow it to be transported remotely from the production site. The successful candidate will be mainly responsible of the hardware development side of the project and will work together with a PhD student and another Research Fellow, both already appointed. Furthermore, the project is done in partnership with Jasco, a UK based company specialising in supercritical-fluids. The position is tenable from 13 Feb 2017 (or as soon as possible thereafter) with initial appointment for 2 years and there are already enough funds for a further extension of 1 year or more, subject to ...
I have a question for those of you who feed raw or barf type diets. I have a Dobe in the house that is anorexic. Health wise hes checked out normal (including bloodwork and trypsin testing) but its a struggle to get him to eat enough food to keep weight on him. I try to get him to eat at least 6 cups of kibble a day with a can of food mixed in for flavor interest. Without the canned food forget it! He wont eat. On really good days which are few and far between I can get him to eat 2 meals and put more food down him that way. Weve tried many different brands of food including the higher end stuff (Canidae ect) over a long period of time. Hes now almost a year and a half so its not like we change his food all the time and have created a picky monster. I though about a home cooked diet, but he wont eat people food either! So I made him some satin balls which Ive used on another thin dog I had (made a world of difference) and have finally gotten him to the point where he thinks they are ...
K 16. novembru je spolu evidovaných 119 prípadov moru, ktoré boli laboratórne potvrdené. Z toho bolo zaznamenaných 40 úmrtí. Iba 2% hlásených prípadov majú pľúcne formu.. Tieto prípady boli hlásené v 16-ich okresoch siedmich krajov. Antananarivo, hlavné mesto a najväčšie mesto v Madagaskare, oznámilo o výskyte 2 prípadov moru, vrátane 1 úmrtia. V súčasnej dobe existuje riziko rýchleho šírenia nákazy v dôsledku mesta vysokou hustotou obyvateľstva a slabého systému zdravotnej starostlivosti.. Charakteristika nákazy. Mor je bakteriálne ochorenie spôsobené baktériou Yersinia pestis. Ochorenie sa šíri z jedného hlodavca na druhého blchami. U ľudí poštípaních infikovanými blchami sa zvyčajne vyvinie bubonická forma moru (opuchy lymfatických uzlín). Ak sa baktérie dostanú do pľúc, u pacienta sa objavia zápal pľúc (pľúcny mor), ktorý sa potom prenáša z človeka na človeka prostredníctvom infikovaných kvapôčok pri kašľaní. ...
Cancer is one of the most dangerous human diseases, expected to kill about 13.3 million people annually by 2030. Protein extracts of Lactobacillus sps (MTCC 41...
My year old, 60 lb., female, Rott/Lab mix was diagnosed with a grade 4 heart murmur on Friday. (5/11/07) Yesterday she went in for a chest X-Ray and a ultrasound of her heart. The information was sent to a Cardiologist. His diagnoses was in layman terms…a valve in her heart is not closing properly and there isnt much we can do about it. She was born with this defect. My Vet did say I could take her to Colorado State University to have surgery. Thats not possible and no way could we afford such a expensive procedure with no guarantee of a successful outcome, nor would I want to put my baby girl through that. SO…my Vet wants to put her on Enalipril. From my understanding, this could cause kidney or liver damage. Ive spent the last day and 1/2 researching herbal supplements that may help her. To make a long story short, Ive already lost 2 dogs in the last 6 months. One was my wonderful Dobe, who got an aggressive form of oral cancer, the other a Wolf Hybrid I adopted at 14 years of age to ...
Cisplatin (Csp) is a recurrently used chemotherapeutic drug but its use is inadequate due to undesirable adverse effects. In search of alternative medicine more attention has been given to phytochemicals. Septilin (Spt), a polyherbal drug and its therapeutic potential is huge but there is a scarcity of studies on its cytotoxic potential on cancer cells. The current study was designed to examine the effects of Spt in combination with Csp on human breast adenocarcinoma (MCF-7) and normal human breast epithelial (MCF-10A) cell lines. Cell viability for Spt treated cells was studied using MTT assay. IC50 value of Csp on MCF-7 cells was found to be 10 µg/mL at 24 h. This dose was further used to study the combined effects of Csp with Spt on MCF-7 and MCF-10A cell lines. Maximum cytotoxicity of Spt on MCF-7 cells was observed at Spt 5 µg/mL. The mechanism of Spt induced cytotoxicity was studied using apoptosis assay. Spt did not show any cytotoxic effects on MCF-10 A normal human breast epithelial ...
When using someone elses work, you must indicate you have borrowed the idea by giving a citation. Besides, if a sources exact words have to be copied, quotation marks must be given. However, verbatim copy of large sections of text (including a few sentences, whole paragraph, and several paragraphs) is moderate to most severe type of plagiarism whether or not that work is cited or quotation marks are used, even though the original sources are from authors own publications.. ...
Philippe Mazars, Nadia Barboule, Véronique Baldin, Simone Vidal, Bernard Ducommun, et al.. Effects of TGF-β1 (transforming growth factor-β1) on the cell cycle regulation of human breast adenocarcinoma (MCF-7) cells. FEBS Letters, Wiley, 1995, 362 (3), pp.295-300. ⟨10.1016/0014-5793(95)00247-7⟩. ⟨hal-02353476⟩ ...
Introduction: We hypothesise that Parkinsonian tremor arises when the caudal zona incerta (cZI) and subthalamic nucleus (STN) are deprived of dopamine and become increasingly responsive to motor cortical alpha and beta frequency oscillations. These oscillations are synchronised and amplified through the basal ganglia thalamocortical loop and entrained into the cerebello-thalamocortical loop via the cZI. Upon receiving potent GABAergic alpha and beta frequency oscillations in cZI afferents, ventrolateral(VL) thalamocortical neurons become hyperpolarised and rebound burst fire, generating 4-6Hz tremor oscillations. We test this hypothesis by stimulating the cZI at alpha and beta frequencies using deep brain stimulation (DBS) in non tremulous parkinsonian patients to see whether a 4-6Hz tremor can be induced. Method: This study included 11 patients with non tremulous PD, who had DBS leads implanted in a range of targets including the cZI, STN, VL nucleus, globus pallidus internus (GPi), ...
Ribuan kertas penyelidikan rakyat Malaysia telah dibentang dan diterbitkan, tetapi sering sukar diperolehi secara terus. Khalayak penyelidik, akademik dan universiti sangat memerlukan kertas-kertas tersebut boleh dirujuk, dalam e-format dan berada di laman web. Ilmu yang sangat bermanfaat ialah yang boleh dirujuk dan dipelajari terus. Bangsa yang menawarkan penyelidikan mereka yang mudah diperolehi pastinya akan berada di hadapan berbanding kerja-kerja yang tersimpan dalam almari-almari dan rak-rak buku.Hakmilik kertas-kertas penyelidikan di sini adalah milik sepenuhnya pengarang kertas berkenaan. Kami hanya mengiklankan dan menyambungkan di mana ia berada.Kami memerlukan sokongan tuan-tuan. Jika tuan-tuan sedang membuat usaha yang sama, sila maklumkan atau sila email url kertas tuan-tuan ke [email protected] Kita memerlukan rantaian pengkalan data yang meluas.Malah jika tuan-tuan berminat untuk belajar di peringkat Master by research atau PhD, sila hubungi mereka ini. Terima kasih. publicma ...
Evaluation of Myocardial Changes During BReast Adenocarcinoma Therapy to Detect Cardiotoxicity Earlier With MRI - The EMBRACE MRI Study
The primary use for procaine is as an anaesthetic. Procaine is used less frequently today, since more effective (and hypoallergenic) alternatives such as lidocaine (Xylocaine) exist. Like other local anesthetics (such as mepivacaine, and prilocaine), procaine is a vasodilator, thus is often coadministered with epinephrine for the purpose of vasoconstriction. Vasoconstriction helps to reduce bleeding, increases the duration and quality of anesthesia, prevents the drug from reaching systemic circulation in large amounts, and overall reduces the amount of anesthetic required.[7] Unlike cocaine, a vasoconstrictor, procaine does not have the euphoric and addictive qualities that put it at risk for abuse. Procaine, an ester anesthetic, is metabolized in the plasma by the enzyme pseudocholinesterase through hydrolysis into para-amino benzoic acid (PABA), which is then excreted by the kidneys into the urine. A 1% procaine injection has been recommended for the treatment of extravasation complications ...
InChI=1S/C20H29N3O2/c1-4-7-14-25-19-15-17(16-10-8-9-11-18(16)22-19)20(24)21-12-13-23(5-2)6-3/h8-11,15H,4-7,12-14H2,1-3H3,(H,21,24) ...
CALCIUM DOBESILATE 78. CANDESARTAN 79. CAPECITABINE 80. CAPTOPRIL 81. CARBIDOPA 82. CARBOCISTEINE ...
Tablet: Calcium Dobesilate 250 mg Effervescent Tablet: 500 mg (Calcium Forte)(Calcium Lactate Gluconate 2.94g +Calcium ... Other calcium preparations include calcium carbonate, calcium citrate malate, and calcium gluconate.[5] The intestine absorbs ... For example, calcium and phosphorus are supplemented in foods through the addition of calcium lactate, calcium diphosphate, and ... Calcium Scandium Titanium Vanadium Chromium Manganese Iron Cobalt Nickel Copper Zinc Gallium Germanium Arsenic Selenium Bromine ...
... such as calcium dobesilate, are being marketed for the specific treatment of microangiopathy. The efficacy of calcium ... "Calcium dobesilate for diabetic retinopathy: a systematic review and meta-analysis". Science China Life Sciences. 58 (1): 101- ... New Avenues for Calcium Dobesilate-Free Radical Scavenger and Growth Factor Inhibition". BioMed Research International. 2017: ... dobesilate has been described e.g. in patients with diabetic retinopathy or diabetic nephropathy. "microangiopathy" at ...
... calcium dobesilate MeSH D02.886.645.600.080.050.100.100 - 4-chloromercuribenzenesulfonate MeSH D02.886.645.600.080.050.100.300 ... calcium dobesilate MeSH D02.455.426.559.389.097.150 - 4-chloromercuribenzenesulfonate MeSH D02.455.426.559.389.097.250 - ... calcium citrate MeSH D02.241.081.901.434.249 - citric acid MeSH D02.241.081.901.434.498 - isocitrates MeSH D02.241.081.901. ... calcium oxalate MeSH D02.241.081.337.646.765 - oxaloacetic acids MeSH D02.241.081.337.646.765.765 - oxaloacetates MeSH D02.241. ...
... combinations C05BX01 Calcium dobesilate C05BX51 Calcium dobesilate, combinations C05CA01 Rutoside C05CA02 Monoxerutin C05CA03 ...
... calcium clofibrate (INN) calcium disodium versenate calcium dobesilate (INN) calcium folinate (INN) calcium glubionate (INN) ... calcium glucoheptonate (INN) calcium levofolinate (INN) calcium pantothenate (INN) calcium saccharate (INN) calcium sodium ... carbasalate calcium (INN) Carbastat Carbatrol Carbaxefed RF carbazeran (INN) carbazochrome salicylate (INN) carbazochrome ... ferriclate (INN) calcium trisodium pentetate (INN) CaldeCORT Calderol caldiamide (INN) Calfort Calmurid HC calteridol (INN) ...
... is a vasoprotective. It is the calcium salt of dobesilic acid. It is a synthetic molecule with the ability ... Calcium dobesilate is administered orally at a daily dose of 0.5-2 g (equivalent to 1-4 tablets). It can also be administered ... The efficacy of calcium dobesilate has been described in patients with microangiopathies such as diabetic retinopathy and ... Zhang X, Liu W, Wu S, Jin J, Li W, Wang N (January 2015). "Calcium dobesilate for diabetic retinopathy: a systematic review and ...
Read the side effects of Calcium Dobesilate as described in the medical literature. In case of any doubt consult your doctor or ... Side effect(s) of Calcium Dobesilate Read the side effects of Calcium Dobesilate as described in the medical literature. In ...
Calcium dobesilate is a vasoprotective. It is the calcium salt of dobesilic acid. It is a synthetic molecule with the ability ... Calcium dobesilate is administered orally at a daily dose of 0.5-2 g (equivalent to 1-4 tablets). It can also be administered ... The efficacy of calcium dobesilate has been described in patients with microangiopathies such as diabetic retinopathy and ... Zhang X, Liu W, Wu S, Jin J, Li W, Wang N (January 2015). "Calcium dobesilate for diabetic retinopathy: a systematic review and ...
Calcium dobesilate , C12H10CaO10S2 , CID 29963 - structure, chemical names, physical and chemical properties, classification, ...
Calcium, Dietary. Calcium Dobesilate. Bone Density Conservation Agents. Physiological Effects of Drugs. Hemostatics. Coagulants ... Calcium Dobesilate vs Flavonoids for the Treatment of Early Hemorrhoidal Disease. The safety and scientific validity of this ... Calcium Dobesilate vs Flavonoids for the Treatment of Early Hemorrhoidal Disease a Randomised Triple Blind Controlled Trial. ... A randomized, triple blind , controlled study will be conducted to compare the efficacy of calcium dobesilate against ...
Calcium dobesilate (CaD, calcium 2,5-dihydroxybenzenesulfonate) is considered an angioprotective drug that can reduce blood ... Zhang X, Liu W, Wu S, Jin J, Li W and Wang N: Calcium dobesilate for diabetic retinopathy: A systematic review and meta- ... Calcium dobesilate may alleviate diabetes‑induced endothelial dysfunction and inflammation. *Authors: *Yijun Zhou ... Demirtas S, Caliskan A, Guclu O, Yazici S, Karahan O, Yavuz C and Mavitas B: Can calcium dobesilate be used safely for ...
... name calcium 2,5-dihydroxybenzenesulfonate Identifiers CAS number ? ATC code C05BX01 PubChem ... It uses material from the Wikipedia article "Calcium_dobesilate". A list of authors is available in Wikipedia. ... Calcium dobesilate). Capillary stabilising agents. bioflavonoids (Rutoside, Monoxerutin, Diosmin, Troxerutin, Hidrosmin) - ...
Supplier of Calcium Dobesilate at the best price. ... Calcium Dobesilate API Suppliers India, Buy Calcium Dobesilate ... Calcium Dobesilate Manufacturers India, Calcium Dobesilate suppliers India, Calcium Dobesilate Exporters India, Calcium ... Calcium Dobesilate Price, Calcium Dobesilate Bulk Drugs Manufacturer India, Calcium Dobesilate ... Dobesilate Powder Manufacturer India, Calcium Dobesilate Powder Supplier India, Calcium Dobesilate API Manufacturer India, ...
Calcium Dobesilate monohydrate (a derivative of Calcium Dobesilate) is reported as an ingredient of Doxiproct in the following ... Calcium Dobesilate. Calcium Dobesilate is reported as an ingredient of Doxiproct in the following countries:. *Czech Republic ...
Calcium Dobesilate This medication is a vasoprotective, prescribed for circulatory disorders.. More Info ... Calcium Carbonate This medication is a dietary supplement, prescribed for calcium deficiency state which may occur in diseases ...
Twenty-eight individuals received dobesilate and 24 placebo. No effect of calcium dobesilate on endothelial function, blood ... Twenty-eight individuals received dobesilate and 24 placebo. No effect of calcium dobesilate on endothelial function, blood ... Twenty-eight individuals received dobesilate and 24 placebo. No effect of calcium dobesilate on endothelial function, blood ... Twenty-eight individuals received dobesilate and 24 placebo. No effect of calcium dobesilate on endothelial function, blood ...
Diabetic nephropathy, a microvascular complication of diabetes, is a progressive kidney disease caused by angiopathy of the capillaries in the kidney glomeruli. Herein, we report a case of a 62-year-old patient with a 30 year history of diabetes, who showed a substantial improvement in diabetic nephropathy on administration of 30 g of Astragalus membranaceus extract per day. After 1 month, estimated glomerular filtration rate increased from 47 to 72 ml/min per 1.73 m2 and was subsequently maintained at the 1-month follow-up. Urinary protein levels also decreased following treatment. Herein, we present and discuss the evidence and mechanism of A. membranaceus on diabetic nephropathy in this patient. ...
99% Purity Calcium Dobesilate Powder for Blood Vessels 20123-80-2 FOB Price: US $ 45-55 / kg. Min. Order: 1 kg ... High Quality Calcium Dobesilate for Blood Vessels FOB Price: US $ 1-100 / Piece. Min. Order: 1 Piece ... 98% (HPLC) Calcitonin Salmon CAS 47931-85-1 for Reducing Blood Calcium FOB Price: US $ 2.7-3 / mg. Min. Order: 5 mg ...
The primary use for procaine is as an anaesthetic. Procaine is used less frequently today, since more effective (and hypoallergenic) alternatives such as lidocaine (Xylocaine) exist. Like other local anesthetics (such as mepivacaine, and prilocaine), procaine is a vasodilator, thus is often coadministered with epinephrine for the purpose of vasoconstriction. Vasoconstriction helps to reduce bleeding, increases the duration and quality of anesthesia, prevents the drug from reaching systemic circulation in large amounts, and overall reduces the amount of anesthetic required.[7] Unlike cocaine, a vasoconstrictor, procaine does not have the euphoric and addictive qualities that put it at risk for abuse. Procaine, an ester anesthetic, is metabolized in the plasma by the enzyme pseudocholinesterase through hydrolysis into para-amino benzoic acid (PABA), which is then excreted by the kidneys into the urine. A 1% procaine injection has been recommended for the treatment of extravasation complications ...
InChI=1S/C20H29N3O2/c1-4-7-14-25-19-15-17(16-10-8-9-11-18(16)22-19)20(24)21-12-13-23(5-2)6-3/h8-11,15H,4-7,12-14H2,1-3H3,(H,21,24) ...
... ... Be the first to review "ANHYDROUS CALCIUM DOBESILATE LIGNOCAINE HYDRCHLORIDE 0.25%, LIGNOCAINE 3%,HYDROCORTISONE ACETATE 0.25%, ...
Calcium Dobesilate / pharmacology* * Cell Differentiation / drug effects * Cell Division / drug effects* * Cell Proliferation ... This finding supports an important role for dobesilate in glioma growth, suggesting that dobesilate should be a treatment to be ... Dobesilate diminishes activation of the mitogen-activated protein kinase ERK1/2 in glioma cells J Cell Mol Med. Jan-Mar 2006;10 ... Here we report that immunocytochemical and Western blot data unequivocally show that treatment of cell cultures with dobesilate ...
... six received 100 mg/kg of intravenous calcium dobesilate, and six received 200 mg/kg of intravenous calcium dobesilate before ... six received 100 mg/kg of intravenous calcium dobesilate, and six received 200 mg/kg of intravenous calcium dobesilate before ... six received 100 mg/kg of intravenous calcium dobesilate, and six received 200 mg/kg of intravenous calcium dobesilate before ... six received 100 mg/kg of intravenous calcium dobesilate, and six received 200 mg/kg of intravenous calcium dobesilate before ...
Moreover, calcium dobesilate (2,5-dihydroxybenzene sulfonate) is a drug that inhibits vascular smooth muscle cell growth and ... The purpose of this study is to determine the efficacy of calcium dobesilate in combination with pulsed dye laser for the ... If the subject meets the inclusion criteria and informed consent is obtained, the subject will receive 2.5% calcium dobesilate ... As a synthetic inhibitor of fibroblast growth factor (FGF), calcium dobesilate targets angiogenic growth factors which lead to ...
This is an interventional case report in which dobesilate was intravitreally injected in a case of recurrent CSC ... To report the anatomic and functional outcome of intravitreal dobesilate to treat recurrent central serous chorioretinopathy ( ... Calcium dobesilate is the active principle of Doxium a drug used for more than 35 years. It has been orally administered for ... Leal EC,Martins J,Voabil P,Liberal J,Chiavaroli C,Bauer J,Cunha-Vaz J,Ambrósio AF,Calcium dobesilate inhibits the alterations ...
20123-80-2 Calcium Dobesilate Brand Name: Meisi New Material Certification: Negotiable Model Number: Negotiable Minimum Order ...
The Early and Late Effects of Calcium Dobesilate on Leg Wound Complications After Saphenous Vein Harvesting for Coronary ... The Early and Late Effects of Calcium Dobesilate on Leg Wound Complications After Saphenous Vein Harvesting for Coronary ... The Early and Late Effects of Calcium Dobesilate on Leg Wound Complications After Saphenous Vein Harvesting for Coronary ... Key Words: Calcium dobesilate; complications; saphenous vein; coronary arter bypass. Received: 13.08.2012 • Accepted: 24.08. ...
List of products with compositon Calcium Dobesilate Topical 0.25%w/w + Hydrocortisone Topical 25%w/w + Lidocaine Topical 3%w/w ... Products of Calcium Dobesilate Topical 0.25%w/w + Hydrocortisone Topical 25%w/w + Lidocaine Topical 3%w/w + Zinc 5%w/w ... Calcium Dobesilate Topical 0.25%w/w + Hydrocortisone Topical 25%w/w + Lidocaine Topical 3%w/w + Zinc 5%w/w. ...
Calcium Dobesilate mixture with Dexamethasone and Lidocaine - Similar structures search, synonyms, formulas, resource links, ... Substance Name: Calcium Dobesilate mixture with Dexamethasone and Lidocaine. RN: 76404-12-1. InChIKey: XEJLOZIIJDYLQR- ... with 2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide and 2,5-dihydroxybenzenesulfonic acid calcium salt (2:1) ... Calcium Dobesilate mixture with Dexamethasone and Lidocaine. Name of Substance. *. Calcium Dobesilate mixture with ...
Calcium dobesilate may improve hemorheology in patients undergoing coronary artery bypass Calcium dobesilate may improve ... Full text: Available Index: LILACS (Americas) Main subject: Calcium Dobesilate / Hemostatics / Coronary Artery Bypass / ... Then, 500 mg of calcium dobesilate was given twice a day to one group of 68 patients for three months. The control group was ... Calcium dobesilate is an angioprotective agent that has positive effects on hemorheological parameters. It is an antioxidant ...
Calcium Dobesilate. A drug used to reduce hemorrhage in diabetic retinopathy.. Vitrectomy ...
Calcium Dobesilate. A drug used to reduce hemorrhage in diabetic retinopathy.. Vitrectomy ...
Tablet: Calcium Dobesilate 250 mg Effervescent Tablet: 500 mg (Calcium Forte)(Calcium Lactate Gluconate 2.94g +Calcium ... Other calcium preparations include calcium carbonate, calcium citrate malate, and calcium gluconate.[5] The intestine absorbs ... For example, calcium and phosphorus are supplemented in foods through the addition of calcium lactate, calcium diphosphate, and ... Calcium Scandium Titanium Vanadium Chromium Manganese Iron Cobalt Nickel Copper Zinc Gallium Germanium Arsenic Selenium Bromine ...
Calcium Chloride. Diphenhydramine Hydrochloride Anafilaxol B - Juventus Prednisolone. Calcium Dobesilate. Lidocaine ... Calcium Levulinate. Pyrilamine Maleate Calpred - Dr. Grossmann Pharmaca Prednisolone Acetate. Chloramphenicol Chlorasone - ... Calcium Chloride. Capsula Articuli Fet.. Cartilago Articuli. Columna Vertebralis. Funiculus Umbilicalis. Glandula Suprarenal. ...
Calcium Dobesilate; Docusate Calcium. Tazorid-P. Piperacillin; Tazobactam. Tenmet. Metoprolol Tartrate. Terbuvent-B. Bromhexine ... Calcium (Milk Calcium); Glucosamine; Methylcobalamin. Cool-Joint Tablets. Calcium Carbonate; Glucosamine Sulfate Potassium; ... Calcium Citrate; Magnesium; Vitamin D3; Zinc. Bonrich-Z Syrup. Calcium Gluconate; Vitamin B12 (Cyanocobalamin); Vitamin B3; ... Calcium Gluconate; Dextrose; Iron (Iron Choline Citrate); L-Lysine; Protein Hydrolysate. Pro-Nutrial-D. Carbohydrates; Fat; ...
Calcium carbimide. *Calcium channel blockers. *Calcium dobesilate. *Calcium salts. *Campanulaceae. *Camphor. *Candesartan ...
  • The efficacy of calcium dobesilate has been described in patients with microangiopathies such as diabetic retinopathy and diabetic nephropathy. (wikipedia.org)
  • A randomized, triple blind , controlled study will be conducted to compare the efficacy of calcium dobesilate against flavanoids in the management of early haemorrhoidal disease. (clinicaltrials.gov)
  • This study was designed to evaluate the plateletinhibiting effect of a new drug, calcium dobesilate, and to compare its efficacy to the known antiplatelet agent, ibuprofen. (elsevier.com)
  • Short-term efficacy of intravitreal dobesilate in central serous chorioretinopathy. (biomedsearch.com)
  • RESULTS: We present anatomical and functional evidences, obtained as early as eleven days after the treatment, of the efficacy of intravitreal dobesilate, in the treatment of chronic CSC condition. (biomedsearch.com)
  • 20. Mentes BB, Gorgul A, Tatlicioglu E, Ayoglu F, Unal S. Efficacy of calcium dobesilate in treating acute attacks of hemorrhoidal disease. (mdedge.com)
  • A randomized, double-blind, controlled study was conducted to investigate the efficacy of oral calcium dobesilate therapy in treating acute attacks of internal hemorrhoids. (tuscoema.org)
  • citation needed] Calcium dobesilate is indicated in states of fragility and altered capillary permeability, e.g. diabetic retinopathy, chronic venous disease and hemorrhoidal disease. (wikipedia.org)
  • Sprague-Dawley rats were divided into four groups: control, streptozotocin-induced diabetic, LTF-treated diabetic, and calcium dobesilate (CaD)-treated diabetic rats. (springer.com)
  • Diabetic Nephropathy Can Be Treated with Calcium Dobesilate by Alleviating the Chronic Inflammatory State and Improving Endothelial Cell Function. (annals.org)
  • Binkhorst PG, van Bijsterveld OP (1976) Calcium dobesilate versus placebo in the treatment of diabetic retinopathy: A double-blind cross-over study. (springer.com)
  • Calcium Dobesilate is used in the treatment of chronic venous insufficiency, haemorrhoids, and diabetic retinopathy. (weloralifesciences.in)
  • Calcium Dobesilate is used for Varicose venis, Diabetic retinopathy, Platelet hyper aggregation, Hemorrhoidal disease, Chronic venous insufficiency and other conditions. (myrralifecare.in)
  • Inhibition of choroidal angiogenesis by calcium dobesilate in normal Wistar and diabetic GK rats. (lens.org)
  • Calcium Dobesilate is a drug for microvascular protection, often used on the treatment and prevention of diabetic retinopathy (DR) and glomerulosclerosis, and shows a tendency of being increasingly applied. (pumch.cn)
  • In one investigation, a 6-month double-masked trial of Pycnogenol versus Dexium 500 (calcium dobesilate) was carried out with type 1 and 2 diabetic participants. (sciencebasedhealth.com)
  • As a synthetic inhibitor of fibroblast growth factor (FGF), calcium dobesilate targets angiogenic growth factors which lead to uncontrolled blood vessel growth. (clinicaltrials.gov)
  • Dobesilate (2,5-dihydroxyphenyl sulfonate, DHPS) was recently identified as the most potent member of a family of fibroblast growth factor (FGF) inhibitors headed by gentisic acid, one of the main catabolites of aspirin. (biomedcentral.com)
  • Our range of products include doxycycline hcl and lactic acid bacillus capsules, amoxicillin cloxacillin and lactic acid bacillus capsules, itraconazole capsules bp, softgel capsules of calcium carbonate calcitriol and zinc, omega 3 fatty acids softel capsules and clindamycin and clotrimazole vaginal softgel capsules. (medishri.in)
  • we are deals in Calcium Dobesilate Capsules 500 mg.Calcium dobesilate should be avoided in patients who are allergic to calcium dobesilate or other similar medicines. (texasindia.net)
  • Recently, it has been shown that dobesilate, an inhibitor of FGF mitogenic activity, shows antiproliferative and proapoptotic activities in glioma cell cultures. (nih.gov)
  • Our findings define the enhancement of anti-inflammatory, anti-angiogenic and anti-tumoral activities by diacetyloxyl derivatization of the FGF inhibitor, dobesilate. (biomedcentral.com)
  • Most calcium supplements range between 500mg and 1000mg. (wkbw.com)
  • Offering you a complete choice of products which include allylestrenol powder, beclomethasone dipropionate, benzyl benzoate, betamethasone sodium phosphate, bisoprolol fumarate and calcium levulinate. (jairadhesales.in)
  • Thirdly, request your gastroenterologist to prescribe you with oral Calcium Dobesilate-Doxium therapy for 3 months. (healthcaremagic.com)
  • Manufacturer of a wide range of products which include calcium citrate malate calcitriol zinc tablets, calcium carbonate and vitamin d3 tablets, calcium vitamin d3 tablets, calcium dobesilate capsule, calcium citrate zinc magnesium hydroxide tablets and calcium citrate calcitriol zinc sulphate and magnesium hydroxide tablet. (weloralifesciences.in)
  • Atorvastatin Calcium is a medicine which is consumed for lowering the bad cholesterol and fats including LDL and triglycerides. (jairadhesales.co.in)
  • Calcium dobesilate (CaD, calcium 2,5-dihydroxybenzenesulfonate) is considered an angioprotective drug that can reduce blood viscosity, platelet activity and capillary permeability, as well as alleviate microcirculatory and hemorheologic abnormalities ( 9 ). (spandidos-publications.com)
  • The results have indicated that preoperative administration of ibuprofen and calcium dobesilate in this animal model significantly diminishes early platelet deposition. (elsevier.com)
  • Calcium Dobesilate is used in the treatment of piles and varicose veins . (1mg.com)
  • Calcitriol, Calcium Citrate, Magnesium Oxide and Zinc Oxide. (weloralifesciences.in)
  • Calcitriol is a form of vitamin D. Calcitriol administration enhances calcium absorption, reduces serum alkaline phosphatase levels, and may reduce elevated parathyroid hormone levels and the histological manifestations of osteitis fibrosa cystic (a skeletal disorder caused by hyperparathyroidism) and defective mineralization. (weloralifesciences.in)
  • This randomised double-blind, placebo-controlled, clinical trial investigated the effect of 3 months of treatment with calcium dobesilate on endothelium-dependent vasodilation, markers of endothelial function, blood pressure, and markers of oxidation in obese, male smokers. (vumc.nl)
  • No effect of calcium dobesilate on endothelial function, blood pressure or markers of oxidation was observed compared with placebo. (vumc.nl)
  • We have shown that endothelial function, blood pressure, and markers of oxidation were not affected by 3 months of treatment with calcium dobesilate in mildly obese, smoking men. (vumc.nl)
  • Improvements with calcium dobesilate were statistically significant only in the increase in erythrocyte flexibility . (bvsalud.org)
  • Twenty-eight individuals received dobesilate and 24 placebo. (vumc.nl)
  • Six animals received an intravenous placebo, six received 12.5 mg/kg of intravenous ibuprofen, six received 100 mg/kg of intravenous calcium dobesilate, and six received 200 mg/kg of intravenous calcium dobesilate before cross-clamping. (elsevier.com)
  • Calcium dobesilate is a medicine that belongs to a group of medicines called venotonics (medicines used to treat venous circulation abnormalities). (salvavidaspharmaceutical.com)
  • A number of medicines, such as calcium dobesilate, are being marketed for the specific treatment of microangiopathy. (wikipedia.org)
  • C12 H10 CaO10 S2 is Calcium Dobesilate in Molecular formula. (e-lactancia.org)
  • In light of the fact that angiogenesis has been implicated in erythematotelangietatic rosacea, calcium dobesilate will be useful in the treatment of this subtype of rosacea. (clinicaltrials.gov)
  • Calcium dobesilate is an angioprotective agent that has positive effects on hemorheological parameters . (bvsalud.org)
  • Moreover, calcium dobesilate (2,5-dihydroxybenzene sulfonate) is a drug that inhibits vascular smooth muscle cell growth and inhibits cellular proliferation. (clinicaltrials.gov)
  • Calcium dobesilate potentiates endothelium-derived hyperpolarizing factor-mediated relaxation of human penile resistance arteries", British Journal of Pharmacology 000 2003, 1-9. (lens.org)
  • Here we report that immunocytochemical and Western blot data unequivocally show that treatment of cell cultures with dobesilate causes a significant decrease of the intracellular levels of ERK1/2 activation, one of the components of the MAPK signalling cascade. (nih.gov)
  • This finding supports an important role for dobesilate in glioma growth, suggesting that dobesilate should be a treatment to be born in mind for glioma management. (nih.gov)
  • Thus, combination treatment with PDL and calcium dobsilate will act in a synergistic manner to reduce the erythema, flushing and telangectasia associated with erythematotelangietatic rosacea. (clinicaltrials.gov)
  • CONCLUSIONS: Intravitreal dobesilate may be an effective treatment option for recurrent CSC. (biomedsearch.com)
  • Hemorheological, oxidant and antioxidant parameters were measured two days after surgery and after a period of treatment with calcium dobesilate . (bvsalud.org)
  • The same improvement in the CCS class was observed in patients regardless of they received the calcium dobesilate treatment . (bvsalud.org)
  • After four days of treatment with calcium dobesilate, the patient returned to the Clínica Godoy, Brazil, with less edema and reductions in body weight and the amount of extracellular and intracellular fluid. (hindawi.com)
  • Case Letters: Treatment of basal cell carcinoma with dobesilate. (lens.org)
  • It completely solved the problem that the take-in of Calcium Dobesilate causes false decrease of Cr, leading to underestimation of kidney damage and delay in treatment. (pumch.cn)
  • This medication is a dietary supplement, prescribed for calcium deficiency state which may occur in diseases such as decreased levels of parathyroid hormone (acute and chronic), postmenopausal osteoporosis, rickets and osteomalacia (softening of the bones). (medindia.net)
  • Therapeutic response of rosacea to dobesilate. (lens.org)
  • Randomised clinical trials of antihypertensive therapy (angiotensin converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs), α blockers, β blockers, calcium channel blockers, diuretics, and their combinations) in patients with diabetes with a follow-up of at least 12 months, reporting all cause mortality, requirement for dialysis, or doubling of serum creatinine levels. (nih.gov)
  • The aim of this study was to determine effects of prophylactic use of calcium dobesilate on complications of saphenectomy after saphenous vein harvest for coronary artery bypass graft. (kosuyoluheartjournal.com)
  • Our study showed that use of calcium dobesilate 2 x 500 mg during three months can decrease complications of saphenectomy after saphenous vein harvest in coronary artery bypass graft. (kosuyoluheartjournal.com)
  • Thus, our data provide no evidence of an effect on vascular function of calcium dobesilate in humans. (vumc.nl)
  • before implanting the synthetic vascular graft in the patient, applying locally to the graft 7B-acetoxy-8, 13-epoxy-1a-6, 9a-trihydroxylabd-14-en-11-one (Forskolin) or a derivative thereof. (google.es)
  • Hyperglycemia in experimental models is associated with perturbed levels of retinal ions (e.g., protons, sodium, magnesium, and calcium) and their regulatory systems. (arvojournals.org)
  • The effect after intravitreal dobesilate injection for CSC might be related to the normalization of retinal architecture. (biomedsearch.com)
  • Normal cellular activity supporting retinal function and healthy vision is strongly dependent on proper cellular demand for ions such as calcium. (arvojournals.org)
  • According to Professor Qiu Ling, deputy director of PUMCH Laboratory, if a patient is given Calcium Dobesilate, it is suggested that Cr, lipids and other indicators are tested 3-5 days after stopping the drug, when the interference is at lowest. (pumch.cn)
  • This combination medication is used to prevent or treat low blood calcium levels in people who do not get enough calcium from their diets. (weloralifesciences.in)
  • Calcium dobesilate lowers the blood pressure in mild to moderate midtrimester hypertension: a pilot study. (doktori.hu)
  • The increase in the erythrocyte deformability index was found to be significant compared with both the pretreatment values and with the 1st and 2nd values of the control group after calcium dobesilate administration , whereas there were no significant changes in blood viscosity , glutathione (GSH) or malondialdehyde (MDA) values after the calcium dobesilate administration . (bvsalud.org)
  • Calcium dobesilate is administered orally at a daily dose of 0.5-2 g (equivalent to 1-4 tablets). (wikipedia.org)
  • Calcium dobesilate, micronized purified flavonoid fraction (MPFF), and hydroxyethylrutoside (ie, oxerutins) were assigned a Grade A recommendation, the highest level of recommendation by the International Consensus Statement (Siena, 2005) and the Consensus Statement led by Nicolaides in 2008, with regard to CVD-related symptoms. (medicographia.com)