Calcium Channel Blockers
Calcium Channels
Voltage-dependent cell membrane glycoproteins selectively permeable to calcium ions. They are categorized as L-, T-, N-, P-, Q-, and R-types based on the activation and inactivation kinetics, ion specificity, and sensitivity to drugs and toxins. The L- and T-types are present throughout the cardiovascular and central nervous systems and the N-, P-, Q-, & R-types are located in neuronal tissue.
Calcium Channels, L-Type
Long-lasting voltage-gated CALCIUM CHANNELS found in both excitable and nonexcitable tissue. They are responsible for normal myocardial and vascular smooth muscle contractility. Five subunits (alpha-1, alpha-2, beta, gamma, and delta) make up the L-type channel. The alpha-1 subunit is the binding site for calcium-based antagonists. Dihydropyridine-based calcium antagonists are used as markers for these binding sites.
Dihydropyridines
Nifedipine
Diltiazem
Ion Channels
Calcium Channels, N-Type
Calcium Channels, T-Type
Amlodipine
Potassium Channel Blockers
Nicardipine
A potent calcium channel blockader with marked vasodilator action. It has antihypertensive properties and is effective in the treatment of angina and coronary spasms without showing cardiodepressant effects. It has also been used in the treatment of asthma and enhances the action of specific antineoplastic agents.
Mibefradil
Nitrendipine
Calcium Signaling
Signal transduction mechanisms whereby calcium mobilization (from outside the cell or from intracellular storage pools) to the cytoplasm is triggered by external stimuli. Calcium signals are often seen to propagate as waves, oscillations, spikes, sparks, or puffs. The calcium acts as an intracellular messenger by activating calcium-responsive proteins.
Calcium Channel Agonists
Agents that increase calcium influx into calcium channels of excitable tissues. This causes vasoconstriction in VASCULAR SMOOTH MUSCLE and/or CARDIAC MUSCLE cells as well as stimulation of insulin release from pancreatic islets. Therefore, tissue-selective calcium agonists have the potential to combat cardiac failure and endocrinological disorders. They have been used primarily in experimental studies in cell and tissue culture.
Nimodipine
Sodium Channel Blockers
omega-Conotoxins
Ion Channel Gating
The opening and closing of ion channels due to a stimulus. The stimulus can be a change in membrane potential (voltage-gated), drugs or chemical transmitters (ligand-gated), or a mechanical deformation. Gating is thought to involve conformational changes of the ion channel which alters selective permeability.
omega-Conotoxin GVIA
Azetidinecarboxylic Acid
Calcium
A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.
Antihypertensive Agents
Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS.
Isradipine
Calcium Channels, P-Type
Chloride Channels
Membrane Potentials
The voltage differences across a membrane. For cellular membranes they are computed by subtracting the voltage measured outside the membrane from the voltage measured inside the membrane. They result from differences of inside versus outside concentration of potassium, sodium, chloride, and other ions across cells' or ORGANELLES membranes. For excitable cells, the resting membrane potentials range between -30 and -100 millivolts. Physical, chemical, or electrical stimuli can make a membrane potential more negative (hyperpolarization), or less negative (depolarization).
Potassium Channels, Inwardly Rectifying
Electrophysiology
Patch-Clamp Techniques
An electrophysiologic technique for studying cells, cell membranes, and occasionally isolated organelles. All patch-clamp methods rely on a very high-resistance seal between a micropipette and a membrane; the seal is usually attained by gentle suction. The four most common variants include on-cell patch, inside-out patch, outside-out patch, and whole-cell clamp. Patch-clamp methods are commonly used to voltage clamp, that is control the voltage across the membrane and measure current flow, but current-clamp methods, in which the current is controlled and the voltage is measured, are also used.
Hypertension
Calcium Channels, R-Type
omega-Agatoxin IVA
Dose-Response Relationship, Drug
Rats, Sprague-Dawley
Flunarizine
Cells, Cultured
Potassium Channels, Voltage-Gated
Potassium
An element in the alkali group of metals with an atomic symbol K, atomic number 19, and atomic weight 39.10. It is the chief cation in the intracellular fluid of muscle and other cells. Potassium ion is a strong electrolyte that plays a significant role in the regulation of fluid volume and maintenance of the WATER-ELECTROLYTE BALANCE.
Potassium Channels, Calcium-Activated
KATP Channels
Heteromultimers of Kir6 channels (the pore portion) and sulfonylurea receptor (the regulatory portion) which affect function of the HEART; PANCREATIC BETA CELLS; and KIDNEY COLLECTING DUCTS. KATP channel blockers include GLIBENCLAMIDE and mitiglinide whereas openers include CROMAKALIM and minoxidil sulfate.
Angiotensin-Converting Enzyme Inhibitors
A class of drugs whose main indications are the treatment of hypertension and heart failure. They exert their hemodynamic effect mainly by inhibiting the renin-angiotensin system. They also modulate sympathetic nervous system activity and increase prostaglandin synthesis. They cause mainly vasodilation and mild natriuresis without affecting heart rate and contractility.
Angiotensin II Type 1 Receptor Blockers
Felodipine
Spider Venoms
Neurons
Cinnarizine
Adrenergic beta-Antagonists
Calcium, Dietary
Barium
Rats, Wistar
Action Potentials
Calcium Chloride
TRPC Cation Channels
Large-Conductance Calcium-Activated Potassium Channels
Tetrodotoxin
Calcium Radioisotopes
Nisoldipine
Shaker Superfamily of Potassium Channels
Myocardium
Rabbits
Drug Therapy, Combination
Guinea Pigs
4-Aminopyridine
Oocytes
Adenosine Triphosphate
Chelating Agents
Potassium Channels
Sodium
Bepridil
Gallopamil
Kv1.3 Potassium Channel
Xenopus laevis
Cyclic Nucleotide-Gated Cation Channels
TRPV Cation Channels
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Potassium Chloride
Small-Conductance Calcium-Activated Potassium Channels
Calcium Carbonate
Amino Acid Sequence
Ion Transport
Agatoxins
Ryanodine Receptor Calcium Release Channel
A tetrameric calcium release channel in the SARCOPLASMIC RETICULUM membrane of SMOOTH MUSCLE CELLS, acting oppositely to SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES. It is important in skeletal and cardiac excitation-contraction coupling and studied by using RYANODINE. Abnormalities are implicated in CARDIAC ARRHYTHMIAS and MUSCULAR DISEASES.
Muscle Contraction
Drug Interactions
Ether-A-Go-Go Potassium Channels
A family of voltage-gated potassium channels that are characterized by long N-terminal and C-terminal intracellular tails. They are named from the Drosophila protein whose mutation causes abnormal leg shaking under ether anesthesia. Their activation kinetics are dependent on extracellular MAGNESIUM and PROTON concentration.
Cell Membrane
Lanthanum
Peptides
Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.
Imidazoles
Nickel
Apamin
Kv1.1 Potassium Channel
Cadmium
Charybdotoxin
Sodium Chloride Symporter Inhibitors
TRPM Cation Channels
Fura-2
Kv1.2 Potassium Channel
KCNQ Potassium Channels
Epithelial Sodium Channels
Enzyme Inhibitors
Kidney
Kv1.5 Potassium Channel
Presynaptic Terminals
The distal terminations of axons which are specialized for the release of neurotransmitters. Also included are varicosities along the course of axons which have similar specializations and also release transmitters. Presynaptic terminals in both the central and peripheral nervous systems are included.
Xenopus
Synaptic Transmission
The communication from a NEURON to a target (neuron, muscle, or secretory cell) across a SYNAPSE. In chemical synaptic transmission, the presynaptic neuron releases a NEUROTRANSMITTER that diffuses across the synaptic cleft and binds to specific synaptic receptors, activating them. The activated receptors modulate specific ion channels and/or second-messenger systems in the postsynaptic cell. In electrical synaptic transmission, electrical signals are communicated as an ionic current flow across ELECTRICAL SYNAPSES.
Anti-Arrhythmia Agents
Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade.
Mollusk Venoms
Venoms from mollusks, including CONUS and OCTOPUS species. The venoms contain proteins, enzymes, choline derivatives, slow-reacting substances, and several characterized polypeptide toxins that affect the nervous system. Mollusk venoms include cephalotoxin, venerupin, maculotoxin, surugatoxin, conotoxins, and murexine.
Acid Sensing Ion Channels
Scorpion Venoms
Neurotransmitter Agents
Protein Subunits
Hippocampus
A curved elevation of GRAY MATTER extending the entire length of the floor of the TEMPORAL HORN of the LATERAL VENTRICLE (see also TEMPORAL LOBE). The hippocampus proper, subiculum, and DENTATE GYRUS constitute the hippocampal formation. Sometimes authors include the ENTORHINAL CORTEX in the hippocampal formation.
Dogs
Calcium Phosphates
Angiotensin Receptor Antagonists
Niflumic Acid
Calcium Isotopes
Rats, Inbred Strains
Vasoconstriction
Gingival Hyperplasia
Calcimycin
An ionophorous, polyether antibiotic from Streptomyces chartreusensis. It binds and transports CALCIUM and other divalent cations across membranes and uncouples oxidative phosphorylation while inhibiting ATPase of rat liver mitochondria. The substance is used mostly as a biochemical tool to study the role of divalent cations in various biological systems.
Signal Transduction
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Muscle, Smooth
Unstriated and unstriped muscle, one of the muscles of the internal organs, blood vessels, hair follicles, etc. Contractile elements are elongated, usually spindle-shaped cells with centrally located nuclei. Smooth muscle fibers are bound together into sheets or bundles by reticular fibers and frequently elastic nets are also abundant. (From Stedman, 25th ed)
Cardiovascular Agents
Extracellular Space
Thapsigargin
Transient Receptor Potential Channels
A broad group of eukaryotic six-transmembrane cation channels that are classified by sequence homology because their functional involvement with SENSATION is varied. They have only weak voltage sensitivity and ion selectivity. They are named after a DROSOPHILA mutant that displayed transient receptor potentials in response to light. A 25-amino-acid motif containing a TRP box (EWKFAR) just C-terminal to S6 is found in TRPC, TRPV and TRPM subgroups. ANKYRIN repeats are found in TRPC, TRPV & TRPN subgroups. Some are functionally associated with TYROSINE KINASE or TYPE C PHOSPHOLIPASES.
Cyclic AMP
RNA, Messenger
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Shab Potassium Channels
Rats, Inbred SHR
Skin Diseases, Eczematous
Glutamic Acid
Nicotinic Acids
Sodium Channels
Acetylcholine
Norepinephrine
Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic.
Calmodulin
A heat-stable, low-molecular-weight activator protein found mainly in the brain and heart. The binding of calcium ions to this protein allows this protein to bind to cyclic nucleotide phosphodiesterases and to adenyl cyclase with subsequent activation. Thereby this protein modulates cyclic AMP and cyclic GMP levels.
Shaw Potassium Channels
Models, Biological
Protein Kinase C
An serine-threonine protein kinase that requires the presence of physiological concentrations of CALCIUM and membrane PHOSPHOLIPIDS. The additional presence of DIACYLGLYCEROLS markedly increases its sensitivity to both calcium and phospholipids. The sensitivity of the enzyme can also be increased by PHORBOL ESTERS and it is believed that protein kinase C is the receptor protein of tumor-promoting phorbol esters.
Hydrogen-Ion Concentration
Receptors, Nicotinic
One of the two major classes of cholinergic receptors. Nicotinic receptors were originally distinguished by their preference for NICOTINE over MUSCARINE. They are generally divided into muscle-type and neuronal-type (previously ganglionic) based on pharmacology, and subunit composition of the receptors.
Intermediate-Conductance Calcium-Activated Potassium Channels
Transfection
Indoles
Quinidine
An optical isomer of quinine, extracted from the bark of the CHINCHONA tree and similar plant species. This alkaloid dampens the excitability of cardiac and skeletal muscles by blocking sodium and potassium currents across cellular membranes. It prolongs cellular ACTION POTENTIALS, and decreases automaticity. Quinidine also blocks muscarinic and alpha-adrenergic neurotransmission.
Drug Resistance
Diminished or failed response of an organism, disease or tissue to the intended effectiveness of a chemical or drug. It should be differentiated from DRUG TOLERANCE which is the progressive diminution of the susceptibility of a human or animal to the effects of a drug, as a result of continued administration.
Protein Structure, Tertiary
The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.
Mutation
Fendiline
Magnesium
G Protein-Coupled Inwardly-Rectifying Potassium Channels
Heart Ventricles
Kv1.4 Potassium Channel
4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid
Amiloride
A pyrazine compound inhibiting SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of potassium and hydrogen ions. Amiloride is used in conjunction with DIURETICS to spare POTASSIUM loss. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p705)
Nitric Oxide
A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels
Enalapril
Vasodilation
Shal Potassium Channels
Treatment Outcome
Trifluoperazine
Binding Sites
Ionic currents underlying spontaneous action potentials in isolated cerebellar Purkinje neurons. (1/6563)
Acutely dissociated cell bodies of mouse Purkinje neurons spontaneously fired action potentials at approximately 50 Hz (25 degrees C). To directly measure the ionic currents underlying spontaneous activity, we voltage-clamped the cells using prerecorded spontaneous action potentials (spike trains) as voltage commands and used ionic substitution and selective blockers to isolate individual currents. The largest current flowing during the interspike interval was tetrodotoxin-sensitive sodium current (approximately -50 pA between -65 and -60 mV). Although the neurons had large voltage-dependent calcium currents, the net current blocked by cobalt substitution for calcium was outward at all times during spike trains. Thus, the electrical effect of calcium current is apparently dominated by rapidly activated calcium-dependent potassium currents. Under current clamp, all cells continued firing spontaneously (though approximately 30% more slowly) after block of T-type calcium current by mibefradil, and most cells continued to fire after block of all calcium current by cobalt substitution. Although the neurons possessed hyperpolarization-activated cation current (Ih), little current flowed during spike trains, and block by 1 mM cesium had no effect on firing frequency. The outward potassium currents underlying the repolarization of the spikes were completely blocked by 1 mM TEA. These currents deactivated quickly (<1 msec) after each spike. We conclude that the spontaneous firing of Purkinje neuron cell bodies depends mainly on tetrodotoxin-sensitive sodium current flowing between spikes. The high firing rate is promoted by large potassium currents that repolarize the cell rapidly and deactivate quickly, thus preventing strong hyperpolarization and restoring a high input resistance for subsequent depolarization. (+info)Activation of human D3 dopamine receptor inhibits P/Q-type calcium channels and secretory activity in AtT-20 cells. (2/6563)
The D3 dopamine receptor is postulated to play an important role in the regulation of neurotransmitter secretion at both pre- and postsynaptic terminals. However, this hypothesis and the underlying mechanisms remain untested because of the lack of D3-selective ligands, paucity of appropriate model secretory systems, and the weak and inconsistent coupling of D3 receptors to classical signal transduction pathways. The absence of ligands that selectively discriminate between D3 and D2 receptors in vivo precludes the study of D3 receptor function in the brain and necessitates the use of heterologous expression systems. In this report we demonstrate that activation of the human D3 dopamine receptor expressed in the AtT-20 neuroendocrine cell line causes robust inhibition of P/Q-type calcium channels via pertussis toxin-sensitive G-proteins. In addition, using the vesicle trafficking dye FM1-43, we show that D3 receptor activation significantly inhibits spontaneous secretory activity in these cells. Our results not only support the hypothesis that the D3 receptor can regulate secretory activity but also provide insight into the underlying signaling mechanisms. We propose a functional model in which the D3 receptor tightly regulates neurotransmitter release at a synapse by only allowing the propagation of spikes above a certain frequency or burst-duration threshold. (+info)Luteinizing hormone inhibits conversion of pregnenolone to progesterone in luteal cells from rats on day 19 of pregnancy. (3/6563)
We have previously reported that intrabursal ovarian administration of LH at the end of pregnancy in rats induces a decrease in luteal progesterone (P4) synthesis and an increase in P4 metabolism. However, whether this local luteolytic effect of LH is exerted directly on luteal cells or on other structures, such as follicular or stromal cells, to modify luteal function is unknown. The aim of the present study was to determine the effect of LH on isolated luteal cells obtained on Day 19 of pregnancy. Incubation of luteal cells with 1, 10, 100, or 1000 ng/ml of ovine LH (oLH) for 6 h did not modify basal P4 production. The addition to the culture medium of 22(R)-hydroxycholesterol (22R-HC, 10 microgram/ml), a membrane-permeable P4 precursor, or pregnenolone (10(-2) microM) induced a significant increase in P4 accumulation in the medium in relation to the control value. When luteal cells were preincubated for 2 h with oLH, a significant (p < 0.01) reduction in the 22R-HC- or pregnenolone-stimulated P4 accumulation was observed. Incubation of luteal cells with dibutyryl cAMP (1 mM, a cAMP analogue) plus isobutylmethylxanthine (1 mM, a phosphodiesterase inhibitor) also inhibited pregnenolone-stimulated P4 accumulation. Incubation with an inositol triphosphate synthesis inhibitor, neomycin (1 mM), or an inhibitor of intracellular Ca2+ mobilization, (8,9-N, N-diethylamino)octyl-3,4,5-trimethoxybenzoate (1 mM), did not prevent the decrease in pregnenolone-stimulated P4 secretion induced by oLH. It was concluded that the luteolytic action of LH in late pregnancy is due, at least in part, to a direct action on the luteal cells and that an increase in intracellular cAMP level might mediate this effect. (+info)Drug-protein binding and blood-brain barrier permeability. (4/6563)
The permeability surface area (PS) product, an index of permeability of the blood-brain barrier (BBB), was measured by using the in situ perfusion method. In the cerebral circulation, the fraction of drug that permeates into the brain through the BBB is not only the unbound fraction but also the fraction dissociated from the protein in the perfusate. The sum of these two fractions, the apparent exchangeable fraction, was estimated by fitting the parameters of the BBB permeability under the condition of varying BSA concentrations in the perfusate. The unbound fraction of drugs in a buffer containing 0.5 mM BSA was measured by using the ultrafiltration method in vitro, and the apparent exchangeable fraction was measured in vivo by using the intracarotid artery injection method. The apparent exchange fraction was 100% for S-8510, 96.5% for diazepam, 90.9% for caffeine, 38.3% for S-312-d, 33.1% for propranolol, and 6.68% for (+)-S-145 Na, and each of these was higher than the corresponding unbound fraction in vitro in all drugs. The apparent exchangeable fractions, for example, were 8 times higher for diazepam and 38 times for S-312-d than the unbound fractions in vitro. The apparent exchangeable fraction of drugs was also estimated from the parameters obtained with the perfusion method. Because drugs can be infused for an arbitrary length of time in the perfusion method, substances with low permeability can be measured. The apparent exchangeable fractions obtained with this method were almost the same as those obtained with the intracarotid artery injection method. (+info)Glomerular size-selective dysfunction in NIDDM is not ameliorated by ACE inhibition or by calcium channel blockade. (5/6563)
BACKGROUND: In patients with insulin-dependent diabetes mellitus (IDDM) and overt nephropathy glomerular barrier size-selectivity progressively deteriorates with time and is effectively improved by angiotensin converting enzyme (ACE) inhibition. Whether similar glomerular functional changes develop in proteinuric patients with non-insulin-dependent diabetes mellitus (NIDDM), and whether antihypertensive agents can favorably affect glomerular filtration of macromolecules in these patients, has not been documented yet. METHODS: We investigated renal hemodynamics and fractional clearance of neutral dextrans of graded sizes, in nine proteinuric patients with NIDDM and renal biopsy findings of typical diabetic glomerulopathy. Six healthy volunteers served as controls. We also investigated the effects of an ACE inhibitor and of a calcium channel blocker, both given in doses targeted to achieve a comparable level of systemic blood pressure control, on glomerular hemodynamics and sieving function. Theoretical analysis of glomerular macromolecule transport was adopted to evaluate intrinsic glomerular membrane permeability properties. RESULTS: Fractional clearance of large macromolecules (42 to 66 A in radius) was significantly higher in diabetic patients than in controls, and the distribution of membrane pore radii was calculated to be shifted towards larger pore sizes in diabetics (mean radius increased from 55 to 60 A). Despite effective blood pressure control, neither antihypertensive affected glomerular hemodynamics to any significant extent. Fractional clearance of dextrans, as well as of albumin and IgG, and total urinary proteins were not modified by either treatments. CONCLUSIONS: These data indicate that patients with NIDDM and overt nephropathy develop abnormalities in size-selective function of the glomerular barrier and, at variance to IDDM, such changes were not ameliorated either by ACE inhibition or calcium channel blockade. (+info)N-type voltage-dependent calcium channels mediate the nicotinic enhancement of GABA release in chick brain. (6/6563)
The role of voltage-dependent calcium channels (VDCCs) in the nicotinic acetylcholine receptor (nAChR)-mediated enhancement of spontaneous GABAergic inhibitory postsynaptic currents (IPSCs) was investigated in chick brain slices. Whole cell recordings of neurons in the lateral spiriform (SpL) and ventral lateral geniculate (LGNv) nuclei showed that cadmium chloride (CdCl2) blocked the carbachol-induced increase of spontaneous GABAergic IPSCs, indicating that VDCCs might be involved. To conclusively show a role for VDCCs, the presynaptic effect of carbachol on SpL and LGNv neurons was examined in the presence of selective blockers of VDCC subtypes. omega-Conotoxin GVIA, a selective antagonist of N-type channels, significantly reduced the nAChR-mediated enhancement of gamma-aminobutyric acid (GABA) release in the SpL by 78% compared with control responses. Nifedipine, an L-type channel blocker, and omega-Agatoxin-TK, a P/Q-type channel blocker, did not inhibit the enhancement of GABAergic IPSCs. In the LGNv, omega-Conotoxin GVIA also significantly reduced the nAChR-mediated enhancement of GABA release by 71% from control values. Although omega-Agatoxin-TK did not block the nicotinic enhancement, L-type channel blockers showed complex effects on the nAChR-mediated enhancement. These results indicate that the nAChR-mediated enhancement of spontaneous GABAergic IPSCs requires activation of N-type channels in both the SpL and LGNv. (+info)Light-induced calcium influx into retinal axons is regulated by presynaptic nicotinic acetylcholine receptor activity in vivo. (7/6563)
Visual activity is thought to be a critical factor in controlling the development of central retinal projections. Neuronal activity increases cytosolic calcium, which was hypothesized to regulate process outgrowth in neurons. We performed an in vivo imaging study in the retinotectal system of albino Xenopus laevis tadpoles with the fluorescent calcium indicator calcium green 1 dextran (CaGD) to test the role of calcium in regulating axon arbor development. We find that visual stimulus to the retina increased CaGD fluorescence intensity in retinal ganglion cell (RGC) axon arbors within the optic tectum and that branch additions to retinotectal axon arbors correlated with a local rise in calcium in the parent branch. We find three types of responses to visual stimulus, which roughly correlate with the ON, OFF, and SUSTAINED response types of RGC reported by physiological criteria. Imaging in bandscan mode indicated that patterns of calcium transients were nonuniform throughout the axons. We tested whether the increase in calcium in the retinotectal axons required synaptic activity in the retina; intraocular application of tetrodotoxin (10 microM) or nifedipine (1 and 10 microM) blocked the stimulus-induced increase in RGC axonal fluorescence. A second series of pharmacological investigations was designed to determine the mechanism of the calcium elevation in the axon terminals within the optic tectum. Injection of bis-(o-aminophenoxy)-N,N,N',N'-tetraacetic acid-AM (BAPTA-AM) (20 mM) into the tectal ventricle reduced axonal calcium levels, supporting the idea that visual stimulation increases axonal calcium. Injection of BAPTA (20 mM) into the tectal ventricle to chelate extracellular calcium also attenuated the calcium response to visual stimulation, indicating that calcium enters the axon from the extracellular medium. Caffeine (10 mM) caused a large increase in axonal calcium, indicating that intracellular stores contribute to the calcium signal. Presynaptic nicotinic acetylcholine receptors (nAChRs) may play a role in axon arbor development and the formation of the topographic retinotectal projection. Injection of nicotine (10 microM) into the tectal ventricle significantly elevated RGC axonal calcium levels, whereas application of the nAChR antagonist alphaBTX (100 nM) reduced the stimulus-evoked rise in RGC calcium fluorescence. These data suggest that light stimulus to the retina increases calcium in the axon terminal arbors through a mechanism that includes influx through nAChRs and amplification by calcium-induced calcium release from intracellular calcium stores. Such a mechanism may contribute to developmental plasticity of the retinotectal system by influencing both axon arbor elaboration and the strength of synaptic transmission. (+info)Retinal input induces three firing patterns in neurons of the superficial superior colliculus of neonatal rats. (8/6563)
By using an in vitro isolated brain stem preparation, we recorded extracellular responses to electrical stimulation of the optic tract (OT) from 71 neurons in the superficial superior colliculus (SC) of neonatal rats (P1-13). At postnatal day 1 (P1), all tested neurons (n = 10) already received excitatory input from the retina. Sixty-nine (97%) superficial SC neurons of neonatal rats showed three response patterns to OT stimulation, which depended on stimulus intensity. A weak stimulus evoked only one spike that was caused by activation of non-N-methyl-D-aspartate (NMDA) glutamate receptors. A moderate stimulus elicited a short train (<250 ms) of spikes, which was induced by activation of both NMDA and non-NMDA receptors. A strong stimulus gave rise to a long train (>300 ms) of spikes, which was associated with additional activation of L-type high-threshold calcium channels. The long train firing pattern could also be induced either by temporal summation of retinal inputs or by blocking gamma-aminobutyric acid-A receptors. Because retinal ganglion cells show synchronous bursting activity before eye opening at P14, the retinotectal inputs appear to be sufficient to activate L-type calcium channels in the absence of pattern vision. Therefore activation of L-type calcium channels is likely to be an important source for calcium influx into SC neurons in neonatal rats. (+info)
Calcium channel - Wikipedia
Calcium channel - Wikipedia
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Lomerizine
... and apoptotic death is reduced through the reduction of calcium-dependent apoptotic agents. While some calcium-channel blockers ... Lomerizine (INN) (also known as KB-2796) is a diphenylpiperazine class L-type and T-type calcium channel blocker. This drug is ... Ertel, T. Godfraind with a contribution by E. (2004). Calcium channel blockers. Basel [u.a.]: Birkhauser. p. 139. ISBN ... Lomerizine works as a calcium antagonist by blocking voltage-dependent calcium channels. A study using [3H]Nitrendipine showed ...
Pulmonary heart disease
"Calcium Channel Blockers". livertox.nih.gov. Retrieved 2015-12-22. "Calcium channel blockers are not recommended for the ... A variety of medications have been developed to relax the blood vessels in the lung, calcium channel blockers are used but only ...
Gynecomastia
Medications that are probably associated with gynecomastia include calcium channel blockers such as verapamil, amlodipine, and ... calcium channel blockers; antifungal medications such as ketoconazole; antibiotics such as metronidazole; tricyclic ...
Biginelli reaction
"Dihydropyrimidine calcium channel blockers. 4. Basic 3-substituted-4-aryl-1,4-dihydropyrimidine-5-carboxylic acid esters. ... are widely used in the pharmaceutical industry as calcium channel blockers, antihypertensive agents, and alpha-1-a-antagonists ...
Clarithromycin
Calcium channel blockersEdit. Concurrent therapy with calcium channel blocker may increase risk of low blood pressure, kidney ... "Calcium-channel blocker-clarithromycin drug interactions and acute kidney injury". JAMA. 310 (23): 2544-2553. doi:10.1001/jama. ... compared to pairing calcium channel blockers with azithromycin, a drug similar to clarithromycin but without CYP3A4 inhibition. ...
Bromocriptine
Beta blockers (e.g., alprenolol, carteolol, cyanopindolol, iodocyanopindolol, isamoltane, oxprenolol, penbutolol, pindobind, ...
Magnesium sulfate
Channel blockers. class I. (Na+ channel blockers). class Ia (Phase 0→ and Phase 3→). *Ajmaline ... Calcium sulfate. Strontium sulfate. Barium sulfate Except where otherwise noted, data are given for materials in their standard ... Other inorganic sulfate salts such as sodium sulfate and calcium sulfate may be used in the same way. ... In a magnesium-deficient marine aquarium, calcium and alkalinity concentrations are very difficult to control because not ...
Amlodipine
... is an angioselective calcium channel blocker and inhibits the movement of calcium ions into vascular smooth muscle ... Wang, JG (2009). "A combined role of calcium channel blockers and angiotensin receptor blockers in stroke prevention". Vascular ... It targets L-type calcium channels in muscle cells and N-type calcium channels in the central nervous system which are involved ... calcium channel blockers exacerbate the situation by preventing the flow of calcium ions into cardiac cells, which is required ...
Fendiline
... is a nonselective calcium channel blocker. Scultéty S, Tamáskovits E (1991). "Effect of Ca2+ antagonists on isolated ...
Dimeditiapramine
... (Tiapamil) is a calcium channel blocker. Tiapamil has been described as an "antianginal agent". Verapamil ... Cocco, G.; Strozzi, C.; Chu, D. (1979). "Human electropharmacology of the calcium antagonist dimeditiapramine (Ro 11-1781) in ...
Milrinone
"Calcium channel blockers in chronic heart failure. The risks of "physiologically rational" therapy". Circulation. 82 (6): 2254- ... Phosphorylation of calcium channels permits an increase in calcium influx into the cell. This increase in calcium influx ... This PKA will phosphorylate many components of the cardiomyocyte such as calcium channels and components of the myofilaments. ... In those with heart failure there may be a decreased amount of calcium within the cardiomyocytes reducing the available calcium ...
Antidote
"Calcium channel blocker poisoning". UpToDate. Retrieved 2019-07-09. https://calpoison.org/news/cardiac-glycoside-poisoning. ... a calcium transporting ATPase, as one host factor required for box jellyfish venom cytotoxicity. Antitoxin Antivenom Snakebite ...
Cinnarizine
... is an antihistamine and calcium channel blocker of the diphenylmethylpiperazine group.[1] It is prescribed for ... Cinnarizine is classified as a selective antagonist of T-type voltage-operated calcium ion channels, because its binding blocks ... due to calcium channel blockade), which happen mostly in brain and the fact that it is also used as a labyrinthine sedative.[14 ... and it has been shown that this drug preferentially binds to its target calcium channels when they are in an open, as opposed ...
Exploding head syndrome
Clomipramine and calcium channel blockers have been tried. While the frequency of the condition is not well studied, some have ... associated with a decline in delta sleep Antidepressant discontinuation syndrome Temporary calcium channel dysfunction PTSD ...
CYP3A4
Sirmans SM, Pieper JA, Lalonde RL, Smith DG, Self TH (July 1988). "Effect of calcium channel blockers on theophylline ... "Oxidation of dihydropyridine calcium channel blockers and analogues by human liver cytochrome P-450 IIIA4". Journal of ... Katoh M, Nakajima M, Yamazaki H, Yokoi T (October 2000). "Inhibitory potencies of 1,4-dihydropyridine calcium antagonists to P- ... egress and solvent channels to dehydrogenation of 4-hydroxy-tamoxifen". Biochimica et Biophysica Acta (BBA) - General Subjects ...
CACNA1G
Kopecky, Benjamin J.; Liang, Ruqiang; Bao, Jianxin (2014). "T-type Calcium Channel Blockers as Neuroprotective Agents". ... Calcium channel, voltage-dependent, T type, alpha 1G subunit, also known as CACNA1G or Cav3.1 is a protein which in humans is ... "Entrez Gene: CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit". Perez-Reyes E, Cribbs LL, Daud A, Lacerda ... Cav3.1 is a type of low-voltage-activated calcium channel, also known as "T-type" for its transient on and off. It is expressed ...
Tardive dyskinesia
Essali, Adib; Soares-Weiser, Karla; Bergman, Hanna; Adams, Clive E (26 March 2018). "Calcium channel blockers for antipsychotic ... or calcium channel blockers (e.g. diltiazem). Tardive dyskinesia most commonly occurs in people with psychiatric conditions who ...
D. James Surmeier
Lang, Yakun; Gong, Dandan; Fan, Yu (2015). "Calcium channel blocker use and risk of Parkinson's disease: A meta-analysis". ... Gudala, Kapil; Kanukula, Raju; Bansal, Dipika (2015). "Reduced Risk of Parkinson's Disease in Users of Calcium Channel Blockers ... "L-type calcium channel blockers and Parkinson's disease in Denmark". Annals of Neurology. 67 (5): 600-6. doi:10.1002/ana.21937 ... "Use of Calcium Channel Blockers and Parkinson's Disease". American Journal of Epidemiology. 175 (7): 627-35. doi:10.1093/aje/ ...
Cardioversion
Class IV drugs are calcium (Ca) channel blockers. They work by inhibiting the action potential of the SA and AV nodes. If the ... Class I agents are sodium (Na) channel blockers (which slow conduction by blocking the Na+ channel) and are divided into 3 ... Not all beta blockers are the same; some are cardio selective (affecting only beta 1 receptors) while others are non-selective ... Class II agents are beta blockers which inhibit SA and AV node depolarization and slow heart rate. They also decrease cardiac ...
AH-1058
L-type calcium channel blockers). Class I antiarrhythmic (sodium channel blocker) characteristics have also been seen, but the ... AH-1058 is a cardioselective L-type calcium channel blocker. AH-1058 binds to the same sites on the alpha-1 subunit of L-type ... verapamil) and benzothiazepines; both of which are well known calcium channel blockers. These sites on the alpha-1 subunit ... AH-1058 is a lipophilic antiarrhythmic calcium channel blocker synthesized by the Pharmaceutical Research Laboratories of ...
Nifedipine
It is a calcium channel blocker of the dihydropyridine type. Nifedipine is taken by mouth and comes in fast- and slow-release ... As calcium channel blocker, nifedipine has a risk of causing gingival hyperplasia A number of persons have developed toxicity ... Nifedipine, sold under the brand name Adalat among others, is a calcium channel blocker medication used to manage angina, high ... Flenady V, Wojcieszek AM, Papatsonis DN, Stock OM, Murray L, Jardine LA, Carbonne B (June 2014). "Calcium channel blockers for ...
Traumatic brain injury
Langham, J; C Goldfrad; G Teasdale; D Shaw; K Rowan (2003). "Calcium channel blockers for acute traumatic brain injury" (PDF). ... calcium channel blockers, PPAR-γ agonists, curcuminoids, ethanol, NMDA antagonists, caffeine. In addition to traditional ... influx of calcium and sodium ions into neurons, and dysfunction of mitochondria. Injured axons in the brain's white matter may ...
Pranidipine
... is a calcium channel blocker. It is a long acting calcium channel antagonist of the dihydropyridine group. Jin Yang ...
Oral manifestations of systemic disease
Malik et al., 2013) Calcium channel blockers (CCBs) are medications prescribed for the treatment of a number of heart ... Livada, R.; Shiloah, J. (January 2014). "Calcium channel blocker-induced gingival enlargement". Journal of Human Hypertension. ...
Manoalide
... is a calcium channel blocker. It has antibiotic, analgesic and anti-inflammatory effects and is found in some sponges ...
Felodipine
... is a calcium channel blocker. Felodipine has additionally been found to act as an antagonist of the ... Felodipine is a medication of the calcium channel blocker type which is used to treat high blood pressure. It was patented in ... Felodipine is a member of the 1,4-dihydropyridine class of calcium channel blockers. It is a racemic mixture, and is insoluble ... an in vitro study on human vascular and cardiac tissues comparing how selective various calcium channel blockers are for ...
Devapamil
... is a calcium channel blocker. It is also known as desmethoxyverapamil, which is a phenylalkylamine (PAA) derivative. ... glutathione and calcium channel blockers in the stress-induced ulcer model in rats". Pharmacological Research. 30 (2): 123-35. ... Devapamil not only inhibits by blocking the calcium gated channels, but also by depolarizing the membrane during the sodium- ... The medical characteristics of this drug, and other phenylalkylamines, depends greatly on the state of the calcium channels ...
Benidipine
... is a calcium channel blocker. Benidipine has additionally been found to act as an antagonist of the ... Benidipine is a dihydropyridine calcium channel blocker for the treatment of high blood pressure (hypertension). It is a triple ... and N-type calcium channel blocker. It is reno- and cardioprotective. It was patented in 1981 and approved for medical use in ...
Enpiperate
... is a calcium channel blocker. Du, Y. L.; Lou, Y. Q. (1989). "Calcium antagonism of enpiperate on isolated rabbit ...
Fantofarone
... is a calcium channel blocker. There are many different calcium channel blockers that show different results in use ... "Synergy between two calcium channel blockers, verapamil and fantofarone (SR33557), in reversing chloroquine resistance in ... Fantofarone and Verapamil are both calcium channel blockers that behave differently in different applications. Fantofarone was ... which is also a calcium channel blocker). Fantofarone showed more effectiveness against a severity of vasospasm than verapamil ...
Lepidium
See also: Receptor/signaling modulators • Ion channel modulators. Taxon identifiers. *Wikidata: Q146217 ...
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鉀離子通道阻滯劑(英語:Potassium channel blocker) (PCB) ... 性鈣通道(英語:Voltage-dependent calcium channel). 突觸後致. 密物質(英語:Postsynaptic density) ... 腎上腺素受體拮抗劑 (α(英語:Alpha blocker) (1(英語:Alpha-1
Ginger
States in which ginger is exported follow the marketing channels of vegetable marketing in India, and the steps are similar to ... water channels are made 60-80 ft apart to irrigate the crop.[29] ... Blockers. *α-Spinasterol (Vernonia tweediana). *AMG-517. * ...
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Calcium Channel Blockers. CCB. 降血壓. 鈣質. Calcium. -. 骨骼細胞營養所需 ... Beta Blockers. β-Blockers. 控制心率、降血壓. 胰高血糖素. Glucagon. -. 升血糖 ... Better Health Channel. [2011-07-
Cav1.2
This gene encodes an alpha-1 subunit of a voltage-dependent calcium channel. Calcium channels mediate the influx of calcium ... Zühlke RD, Bouron A, Soldatov NM, Reuter H (May 1998). "Ca2+ channel sensitivity towards the blocker isradipine is affected by ... calcium channel activity. • metal ion binding. • voltage-gated ion channel activity. • ion channel activity. • protein binding ... high voltage-gated calcium channel activity. • voltage-gated calcium channel activity involved in AV node cell action potential ...
Diuretic
Epithelial sodium channel blockers: amiloride and triamterene.. Calcium-sparing diureticsEdit. The term "calcium-sparing ... The reduced concentration of calcium in the urine can lead to an increased rate of calcium in serum. The sparing effect on ... calcium chloride, ammonium chloride 1. Arginine vasopressin. receptor 2 antagonists amphotericin B, lithium[13][14]. Inhibits ... The potassium-sparing diuretics cause a net increase in calcium lost in urine, but the increase is much smaller than the ...
Rosemary
See also: Receptor/signaling modulators • Ion channel modulators. Taxon identifiers. *Wikidata: Q122679 ... Blockers. *α-Spinasterol (Vernonia tweediana). *AMG-517. *Asivatrep. *BCTC. *Cannabigerol (cannabis). *Cannabigerolic acid ( ...
Pepper spray
Blockers. *α-Spinasterol (Vernonia tweediana). *AMG-517. *Asivatrep. *BCTC. *Cannabigerol (cannabis). *Cannabigerolic acid ( ... See also: Receptor/signaling modulators • Ion channel modulators. Retrieved from "https://en.wikipedia.org/w/index.php?title= ...
A-366,833
Ion channel. modulators. Calcium blockers. *Gabapentin. *Gabapentin enacarbil. *Mirogabalin. *Pregabalin. *Ziconotide. Sodium ...
ସୁପ୍ରାଭେଣ୍ଟ୍ରିକୁଲାର ଟାକିକାର୍ଡ଼ିଆ - ଉଇକିପିଡ଼ିଆ
... calcium channel blockers) ବା ବିଟା ବ୍ଲକର (beta blockers) ଦିଆଯାଏ । ଦୀର୍ଘକାଳୀନ ଭିତ୍ତିରେ କେତେକ ଲୋକଙ୍କର ଆସ୍ପିରିନ (aspirin) ବା ...
Pentamidine
L-Type calcium channel blockers (e.g., dihydropyridines: nifedipine). *Nebivolol (beta blocker) ... "Structural insights into calcium-bound S100P and the V domain of the RAGE complex". PLOS ONE. 9 (8): e103947. Bibcode ...
Gitelman syndrome
This has been suggested to be the result of a putative basolateral Na-Ca exchanger and apical calcium channel. ... or epithelial sodium channel blockers such as amiloride can be used to decrease urinary wasting of potassium.[1] ... This symporter is a channel responsible for the transport of multiple electrolytes such as sodium, chloride, calcium, magnesium ... channel (ClC-Kb), and the Na+/K+-ATPase. Indicated also are the recently identified magnesium channel TRPM6 in the apical ...
Bradykinin
... raises internal calcium levels in neocortical astrocytes causing them to release glutamate, though this finding has ... Blockers. *α-Spinasterol (Vernonia tweediana). *AMG-517. *Asivatrep. *BCTC. *Cannabigerol (cannabis). *Cannabigerolic acid ( ... See also: Receptor/signaling modulators • Ion channel modulators. Retrieved from "https://en.wikipedia.org/w/index.php?title= ...
Lamotrigine
... but could relate to actions of the drug on voltage-activated calcium channels. Lamotrigine blocks T-type calcium channels ... Ion channel blockers. *Anticonvulsants (e.g., gabapentin, pregabalin, carbamazepine, oxcarbazepine, lacosamide, lamotrigine) ... It also blocks L-, N-, and P-type calcium channels and has weak 5-hydroxytryptamine-3 (5-HT3) receptor inhibition. These ... However, it does inhibit native and recombinant high-voltage-activated calcium channels (N- and P/Q/R-types) at therapeutic ...
Medication
General: β-receptor blockers ("beta blockers"), calcium channel blockers, diuretics, cardiac glycosides, antiarrhythmics, ... beta-blockers, α blockers, calcium channel blockers, thiazide diuretics, loop diuretics, aldosterone inhibitors ... General: adrenergic neurone blocker, astringent, ocular lubricant. *Diagnostic: topical anesthetics, sympathomimetics, ... Anti-glaucoma: adrenergic agonists, beta-blockers, carbonic anhydrase inhibitors/hyperosmotics, cholinergics, miotics, ...
Antiemetic
Calcium channel blockers. *renin-angiotensin system *ACE inhibitors. *Angiotensin II receptor antagonists ... cation uptake by the receptor channel and contraction of isolated guinea-pig ileum", Eur J Pharmacol, 530 (1-2): 136-43, doi: ...
Domperidone
Ion channel modulators. Calcium. VDCCs. Blockers. *L-type-selective: Dihydropyridines: Amlodipine. *Aranidipine ... The cause is thought to be blockade of hERG voltage-gated potassium channels.[41][42] The risks are dose-dependent, and appear ... the voltage-gated potassium channel KCNH2 gene (hERG/Kv11.1), and the α1D-adrenoceptor ADRA1D gene.[58] ...
Paraldehyde
Channel. modulators. Sodium blockers. *Hydantoins: Ethotoin. *Fosphenytoin. *Mephenytoin. *Phenytoin#; Ureides: ... Calcium blockers. *Oxazolidinediones: Ethadione. *Paramethadione. *Trimethadione; Succinimides: Ethosuximide#. *Mesuximide. * ...
Dihydropyridine
They are particularly well known in pharmacology as L-type calcium channel blockers, used in the treatment of hypertension. ... Compared with certain other L-type calcium channel blockers (for example those of the phenylalkylamine class such as verapamil ... The pharmaceutical drug finerenone is also a dihydrophyridine derivative, but does not act as a calcium channel blocker but as ... Dihydropyridine class L-type calcium channel blockers include, in alphabetical order (brand names vary in different countries ...
Selexipag
Calcium channel blockers. *Diuretics. *Digoxin. *Oxygen therapy. *Warfarin. *v. *t. *e. Prostanoid signaling modulators ...
Indantadol
Ion channel. modulators. Calcium blockers. *Gabapentin. *Gabapentin enacarbil. *Pregabalin. *Ziconotide. Sodium blockers. * ...
Vasospasm
... also known as beta blockers or β-blockers) such as propranolol. L-type calcium channel blockers can induce dilation of the ... Certain calcium channel blocker should be avoided with some beta-receptor blockers since they may cause severe bradycardia and ... Beta-receptor antagonists do not cause vasodilation, but like L-type calcium channel blockers, they do reduce the heart's ... calcium channel blockers). The potential for these contraindications and drug-drug interaction could lead to asystole and ...
Ketorolac
Ion channel. modulators. Calcium blockers. *Alcohol (ethanol). *Gabapentin. *Gabapentin enacarbil. *Mirogabalin. *Pregabalin ...
Atrial fibrillation
In those with chronic AF either beta blockers or calcium channel blockers are recommended.[109] ... They are not as effective as either beta blockers or calcium channel blockers.[5] ... Non-dihydropyridine calcium channel blockers (e.g., diltiazem or verapamil). *Cardiac glycosides (e.g., digoxin) - have less ... calcium sensitivity can lead to an accumulation of intracellular calcium and causes downregulation of L-type calcium channels. ...
Analgesic
N-type calcium-channel blocker.. Intrathecal.. Protein binding = 50%; half-life = 2.9-6.5 hours; excretion = urine (,1%).[122] ... Binds to the α2δ-1 subunit of voltage gated calcium ion channels in the spinal cord. May also modulate NMDA receptors and ... Some novel and investigational analgesics include subtype-selective voltage-gated sodium channel blockers such as funapide and ... Comes in calcium salt form; fairly soluble in water.. Is metabolised to aspirin and urea. As per aspirin.. Oral.. No data.. ...
Citrus
... fruit juice that can be used to lower blood pressure because it interferes with the metabolism of calcium channel blockers.[34] ...
Parkinson's disease
... calcium channel blockers (isradipine) and growth factors (GDNF).[56] Preclinical research also targets alpha-synuclein.[129] A ... There have been preliminary indications that the use of anti-inflammatory drugs and calcium channel blockers may be protective. ...
Stimulant
Calcium channel blockers. *renin-angiotensin system *ACE inhibitors. *Angiotensin II receptor antagonists ... National Geographic Channel. Archived from the original on 8 July 2016.. *^ United Nations Office on Drugs and Crime (2007). ...
NMDA receptor
Uncompetitive NMDA receptor antagonists, or channel blockers, enter the channel of the NMDA receptor after it has been ... and calcium (Ca2+) ions into the cell and potassium (K+) out of the cell.[5][6][7][8] Ca2+ flux through NMDA receptors in ... Memantine is an example of an uncompetitive channel blocker of the NMDA receptor, with a relatively rapid off-rate and low ... Most NMDAR antagonists are uncompetitive or noncompetitive blockers of the channel pore or are antagonists of the glycine co- ...
Ivermectin
These drugs include statins, HIV protease inhibitors, many calcium channel blockers, lidocaine, the benzodiazepines, and ... The drug binds to glutamate-gated chloride channels (GluCls) in the membranes of invertebrate nerve and muscle cells, causing ... Yates DM, Wolstenholme AJ (August 2004). "An ivermectin-sensitive glutamate-gated chloride channel subunit from Dirofilaria ... GluCls are invertebrate-specific members of the Cys-loop family of ligand-gated ion channels present in neurons and myocytes. ...
Calcium Channel Blockers
... This learning resource is a 5-minute animation about calcium channel blocker in YouTube. Learning ... pharmacology, calcium channel blockers, heart medication, pharmacy, nursing Disciplines:. * Science and Technology / Health ... You just viewed Calcium Channel Blockers. Please take a moment to rate this material. ... about calcium channel blockers is easy and fun at Rutgers University, School of Nursing in Stratford, NJ. ...
How do calcium channel blockers work?
they block the small pores in cells that let calcium pass through, and widen blood vessels as well as affect the activity o ... What are calcium channel blockers?. NEXT QUESTION: Which calcium channel blockers have been studied to treat bipolar disorder? ... How do calcium channel blockers work?. ANSWER These drugs are usually used to treat high blood pressure or heart problems. They ... So calcium channel blockers have been studied as a treatment for bipolar disorder, but there isnt enough evidence yet that ...
Calcium Channel Blockers | HealthCentral
... also called calcium antagonists, are a newer category of medications which are used to treat heart disease and hypertension. ... Calcium channel blockers, also called calcium antagonists, are a newer category of medications which are used to treat heart ... Calcium channel blockers, like verapamil and its cousins, do not quite lock the revolving door, but they significantly slow ... Do you recommend use of calcium channel blockers for my problem?. Are there alternative drugs for controlling hypertension or ...
Calcium channel blockers: Uses, types, and side effects
Calcium channel blockers are a common type of medication for high blood pressure and heart conditions. We discuss how these ... What is a calcium channel blocker?. Share on Pinterest. A doctor may prescribe calcium channel blockers to treat high blood ... Calcium channel blockers reduce the amount of calcium that can enter muscle cells in the heart and blood vessel walls via these ... Researchers have found that both beta-blockers and calcium channel blockers are effective in lowering blood pressure, making ...
Calcium channel blockers? - Migraineurs Support - MedHelp
... what calcium channel blocker did you try and did you have any side-effects? Did it help your migraines? I am... ... I was wondering if anyone here has tried a calcium channel blocker before? If so, ... I was wondering if anyone here has tried a calcium channel blocker before? If so, what calcium channel blocker did you try and ... I hope the Calcium Channel Blockers work for you! I dont think the Beta Blocker is working for me either at this point (we ...
Treating Hypertension with Calcium Channel Blockers
Calcium channel blockers are used to treat high blood pressure. Theyre as effective as ACE inhibitors in reducing blood ... What are calcium channel blockers?. Calcium channel blockers (CCBs) are a class of medications used to treat high blood ... How calcium channel blockers work. CCBs reduce blood pressure by limiting the amount of calcium or the rate at which calcium ... Natural calcium channel blockers. Magnesium is an example of a nutrient that acts as a natural CCB. Research has shown that ...
calcium-channel blocker | FactMonster
They prevent the calcium ions needed for muscle contraction from entering the cells of smooth and cardiac muscle. This causes ... calcium-channel blocker calcium-channel blocker. calcium-channel blocker, any of a class of drugs used in treating hypertension ... Cardizem (diltiazem) is a common calcium-channel blocker. The Columbia Electronic Encyclopedia, 6th ed. Copyright © 2012, ... Some calcium-channel blockers, such as Procardia (nifedipine), slow the electrical impulses that run through heart muscle, thus ...
Calcium channel blockers and cancer. . . and other stories | The BMJ
Calcium channel blockers and cancer. . . and other stories BMJ 2018; 361 :k2529 ... There has been some anxiety that calcium channel blockers might encourage growth of malignant cells by reducing intracellular ... mortality from breast cancer was no higher in women who had taken calcium channel blockers than in women who had never used ... Calcium channel blockers and cancer. . . and other stories. BMJ 2018; 361 doi: https://doi.org/10.1136/bmj.k2529 (Published 14 ...
How do calcium channel blockers work for high blood pressure?
... calcium channel blockers (sometimes called ccbs for short, or calcium antagonists) dont let calcium into certain muscle cells ... How do calcium channel blockers work for high blood pressure?. ANSWER To treat blood high blood pressure, calcium channel ... blockers (sometimes called CCBs for short, or calcium antagonists) dont let calcium into certain muscle cells in your heart ... How do peripheral adrenergic blockers work to treat high blood pressure?. *How do vasodilators work to treat high blood ...
September: Calcium channel blockers | News | University of Bristol
Calcium channel blockers may be effective in treating memory loss associated with Alzheimers. Treating diseased brain cells ... Researchers at the University of Bristol have identified that calcium channel blockers may be effective in treating memory loss ... This overload was due to the overproduction of the gene encoding a channel, known as the L-type channel, which allows calcium ... found treating a diseased brain cell with a blocker of the L-type channel reduced the number of calcium ions able to flow into ...
Calcium-channel blocker overdose: MedlinePlus Medical Encyclopedia
Calcium-channel blockers are a type of medicine used to treat high blood pressure and heart rhythm disturbances. They are one ... The specific ingredients in each type of calcium-channel blocker vary. However, the main ingredient is called a calcium-channel ... Calcium-channel blockers are a type of medicine used to treat high blood pressure and heart rhythm disturbances. They are one ... Calcium channel blockers. In: Aronson JK, ed. Meylers Side Effects of Drugs. 16th ed. Waltham, MA: Elsevier; 2016:23-39. ...
Calcium Channel Blocker News, Research
A type of blood pressure lowering medication, called a calcium-channel blocker, may be linked with an increased risk of a type ... Atomic level analysis reveals how two classes of calcium channel blockers produce different effects An atomic level analysis ... Two-drug combinations containing calcium channel blocker significantly lowers BP In the largest randomized controlled trial of ... two frontline two-drug combinations that included the long-acting calcium channel blocker, amlodipine, were able to drive down ...
Calcium Channel Blockers & GERD | Livestrong.com
Drug InfoNet - Calcium Channel Blockers - [heart]
Calcium Channel Blockers Question:What is the risk of mortality with calcium channel blockers? Answer: There has been a lot of ... Doctors Answers to "Frequently Asked Questions" - Calcium Channel Blockers. These comments are made for the purpose of ... This was initiated after a presentation of data which compared relative mortality of beta-blockers and calcium blockers. This ... by the Food and Drug Administration has recently stated that there appears to be no excess risk with calcium channel blockers- ...
ExRx.net : Calcium Channel Blockers (CCB)
Some calcium channel blockers slow heart rate, which can further reduce blood pressure, relieve chest pain (angina) and control ... Massie BM (1998) The safety of calcium-channel blockers. Clin Cardiol. 21(12 Suppl 2):II12-7. ... Inhibits transmembrane calcium influx (prevents calcium from entering cells) in cardiac (heart) and vascular smooth muscle ( ...
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Calcium channel blockers - definition of Calcium channel blockers by The Free Dictionary
Calcium channel blockers synonyms, Calcium channel blockers pronunciation, Calcium channel blockers translation, English ... dictionary definition of Calcium channel blockers. n. Any of a class of drugs that inhibit the movement of calcium ions across ... calcium channel blocker. (redirected from Calcium channel blockers). Also found in: Medical.. Related to Calcium channel ... Calcium channel blockers - definition of Calcium channel blockers by The Free Dictionary https://www.thefreedictionary.com/ ...
Periodic paralysis and ventricular tachycardia: Possible role of calcium channel blockers | SpringerLink
Ventricular tachycardia Periodic paralysis Calcium channel blockers This is a preview of subscription content, log in to check ... the first time the results of an electrophysiologic study of a similar case and the successful use of calcium channel blockers ... Rojas CV, Wang J, Schwartz LS, et al (1991) A Met-to-Val mutation in the skeletal muscle Na+ channel a subunit in hyperkalemic ... Cranefield PF, Aronson RS, Wit AL (1974) Effect of verapamil on the normal action potential and on calcium-dependent slow ...
What is the role of calcium channel blockers in urinary incontinence treatment?
... ) and What is the role of calcium channel ... What is the role of calcium channel blockers in urinary incontinence treatment?. Updated: Mar 19, 2019 ... 71] The presumed mechanism of action is through calcium antagonism. More work is needed before this treatment is recommended. ... blockers in urinary incontinence treatment? What to Read Next on Medscape. Related Conditions and Diseases. * Urodynamic ...
New Warning on Switching from Posicorto Other Calcium Channel Blockers
Portland report that four individuals went into shock recently after clinicians switched them from mibefradil to other calcium ... channel blockers and that one of the four patients died. ... 39 for a list of all the other calcium channel blockers. Let me ... New Warning on Switching from Posicorto Other Calcium Channel Blockers View More ... to other calcium channel blockers and that one of the four patients died. ...
Snake Venom Calcium Channel Blocker
Fibromuscular Dysplasia Medication: Fibrinolytic agents, Antiplatelet agents, Anticoagulants, Calcium channel blockers
List of Angiotensin II inhibitors with calcium channel blockers - Drugs.com
Compare angiotensin II inhibitors with calcium channel blockers. View important safety information, ratings, user reviews, ... Angiotensin II inhibitors with calcium channel blockers. What are Angiotensin II inhibitors with calcium channel blockers?. ... Calcium channel blockers block calcium from entering cells of the heart and smooth muscle in the walls of blood vessels. This ... List of Angiotensin II inhibitors with calcium channel blockers:. Filter by: -- all conditions --. High Blood Pressure. ...
Calcium-channel blockers for Raynaud's phenomenon in systemic sclerosis
Calcium-channel blockers for RP in SSc have been tested in several small clinical trials and appear to lead to significant ... Calcium-channel blockers for Raynauds phenomenon in systemic sclerosis Arthritis Rheum. 2001 Aug;44(8):1841-7. doi: 10.1002/ ... Conclusion: Calcium-channel blockers for RP in SSc have been tested in several small clinical trials and appear to lead to ... This study was a meta-analysis to determine the efficacy of calcium-channel blockers for the treatment of RP in SSc. The ...
What Are Calcium Channel Blockers? - Video - Sharecare
Calcium channel blockers are medicates that relax the arteries, says Mary Ann McLaughlin, MD, medical director of the Cardiac ... What Are Calcium Channel Blockers? (0:43) Calcium channel blockers are medicates that relax the arteries, says Mary Ann ... calcium channel blocker as a joint is more likely to relax that and prevent that from happening. Calcium Channel Blockers also ... Calcium channel blockers are medications that relax the arteries. So some people have a spasm in their artery, ...
Calcium channel blocker - Wikipedia
"Calcium-Channel Blockers (CCBs)". CV Pharmacology. Retrieved 2020-02-07.. *^ Domenic A. Sica, MD. "Calcium Channel Blocker- ... Calcium channel blockers (CCB), calcium channel antagonists or calcium antagonists[2] are a group of medications that disrupt ... of people receiving calcium channel blocker, is caused by calcium channel blockers preferential arteriolar or precapillary ... through calcium channels.[3] Calcium channel blockers are used as antihypertensive drugs, i.e., as medications to decrease ...
Dihydropyridine Calcium Channel Blocker
... , Amlodipine, Norvasc, Nimodipine, Dihydropyridine. ... Dihydropyridine Calcium Channel Blocker. Dihydropyridine Calcium Channel Blocker Aka: Dihydropyridine Calcium Channel Blocker, ... Beta Blocker Beta Blocker Overdose Bile Binding Resin Bradycardia due to Medications Bretylium Calcium Channel Blocker Calcium ... Non-Dihydropyridine Calcium Channel Blocker Norepinephrine PCSK9 Inhibitor Perioperative Beta Blocker Peripheral Acting ...
Now Calcium Channel Blockers Are Associated With Brain Damage, Memory Loss | EurekAlert! Science News
... another in a string of adverse findings about calcium channel blockers. ... Calcium channel blockers and certain kinds of diuretics are associated with brain damage and memory loss, according to a report ... WINSTON-SALEM, NC -- Calcium channel blockers and certain kinds of diuretics are associated with brain damage and memory loss, ... Furberg said the results are part of a pattern of problems with calcium channel blockers that began to emerge with a report at ...
CCBsVerapamilAmlodipineAntagonistsMedicationsDrugs called calcium channelDifferent calcium channelAlpha Blockers2019Amount of calciumDiureticOverdoseAngiotensinDiuretics and beta-blockersMedicationCardiacDihydropyridinesCardiovascularBloodMechanismPlaceboVascularTake calcium channelProcardiaInhibitionAntihypertensive agentsAngina pectorisRole of calcium channelEffect of calcium channelSafety of calcium-channelClasses of calcium channelInhibitBipolar disorderModulatorsHeartChloride2016RelaxReduce sRAGE releaseTherapeuticDihydropyridine calciumPatients with hypertensionBetaIonsMyocardialSelective blockersCommonlyDigoxinPancreatic cancer riskAntagonistIntracellular
CCBs26
- Calcium channel blockers (CCBs) are a class of medications used to treat high blood pressure. (healthline.com)
- The newest guidelines from the American College of Cardiology recommend that ACE inhibitors, diuretics, angiotensin-receptor blockers (ARBs), and CCBs be the first medications to consider when treating high blood pressure. (healthline.com)
- CCBs reduce blood pressure by limiting the amount of calcium or the rate at which calcium flows into the heart muscle and arterial cell walls. (healthline.com)
- To treat blood high blood pressure, calcium channel blockers (sometimes called CCBs for short, or calcium antagonists) don't let calcium into certain muscle cells in your heart and blood vessels, so it's harder for electrical signals to pass. (webmd.com)
- One such class of medications is calcium channel blockers, or CCBs. (livestrong.com)
- N-type , L-type , and T-type voltage-dependent calcium channels are present in the zona glomerulosa of the human adrenal gland , and CCBs can directly influence the biosynthesis of aldosterone in adrenocortical cells , with consequent impact on the clinical treatment of hypertension with these agents . (wikipedia.org)
- CCBs have been shown to be slightly more effective than beta blockers at lowering cardiovascular mortality , but they are associated with more side effects . (wikipedia.org)
- Several studies showed that calcium channel blockers (CCBs) reduce right ventricular hypertrophy and improve long-term haemodynamics in PAH. (cochrane.org)
- Calcium channel blocker toxicity is the taking of too much of the medications known as calcium channel blockers (CCBs), either by accident or on purpose. (wikipedia.org)
- We describe 4 cases of cardiogenic shock in patients taking mibefradil and beta-blockers who began taking dihydropyridine CCBs. (nih.gov)
- In this opinion paper, we intend to compare some cardiovascular outcomes of dietary antioxidant supplements versus calcium channel blockers (CCBs). (frontiersin.org)
- CHICAGO - Calcium channel blockers (CCBs), specifically the short-acting form of CCBs, which are prescribed to treat high blood pressure, were associated with an increased risk of pancreatic cancer in postmenopausal women, according to a study presented at the AACR Annual Meeting 2018 , April 14-18. (aacr.org)
- They analyzed four types of antihypertensive drugs: beta blockers, diuretics, angiotensin converting enzyme inhibitors (ACEi), and CCBs, and used Cox proportional hazard regression models to obtain hazard ratios for the association of the four types of medication with risk of pancreatic cancer. (aacr.org)
- Ever-use of ACEi, beta blockers, diuretics, and long-acting CCBs was not associated with increased risk of pancreatic cancer. (aacr.org)
- The authors noted that while further research will be necessary to confirm these findings and understand the mechanisms, "the blockage of the calcium channel caused by use of CCBs may potentially reduce sRAGE release and thus further decrease the levels of anti-inflammatory sRAGE. (aacr.org)
- Dihydropyridine Ca 2+ channel blockers (CCBs) are widely accepted in the treatment of premature labour. (mdpi.com)
- Calcium channel blockers (CCBs) are a mainstay in treating hypertension (HTN). (ahajournals.org)
- Ca 2+ channel blockers (CCBs), and especially nifedipine and nicardipine, are among the frequently used tocolytics. (mdpi.com)
- Question Many of my pregnant or lactating patients are taking calcium channel blockers (CCBs) for hypertension. (cfp.ca)
- Calcium channel blockers (CCBs) are commonly used during pregnancy and lactation to treat hypertension, arrhythmia, and preeclampsia. (cfp.ca)
- Population-based data from 5 health maintenance organizations in the United States were used to study the risks of perinatal complications and congenital defects among infants exposed in utero to CCBs or β-blockers. (cfp.ca)
- The risk of neonatal convulsions was in part attributed to the placental transfer of CCBs, leading to a decrease in infants' cellular calcium levels. (cfp.ca)
- Calcium channel blockers (CCBs) are widely used to treat cardiovascular disease (CVD) including hypertension. (frontiersin.org)
- LTCCs have high sensitivity to calcium channel blockers (CCBs) such as dihydropyridine, phenylalkylamine, and diltiazem ( Triggle, 2007 ). (frontiersin.org)
- Calcium channel blockers (CCBs) are prescribed to patients with Marfan syndrome for prophylaxis against aortic aneurysm progression, despite limited evidence for their efficacy and safety in the disorder. (elifesciences.org)
- Many in vitro studies have shown that calcium channel blockers (CCBs) inhibit cell proliferation (Sachinidis et al. (strath.ac.uk)
Verapamil28
- Calcium channel blockers, like verapamil and its cousins, do not quite 'lock' the revolving door, but they significantly slow it down. (healthcentral.com)
- The cardiovascular drugs that have the most favorable profile would be the class of alpha-blockers, ACE inhibitors and ARBs--venodilators, nitrates and slow calcium channel blockers (with the exception of verapamil, which may cause a significant decrease in heart rate response at peak exercise. (thefreedictionary.com)
- Cranefield PF, Aronson RS, Wit AL (1974) Effect of verapamil on the normal action potential and on calcium-dependent slow response canine cardiac Purkinje fibers. (springer.com)
- Korin Miller, SELF , 12 July 2018 Verapamil is a drug that lowers blood pressure and in a class called calcium channel blockers . (merriam-webster.com)
- Fendiline Gallopamil Verapamil (Calan, Isoptin) Benzothiazepine calcium channel blockers belong to the benzothiazepine class of compounds and are an intermediate class between phenylalkylamine and dihydropyridines in their selectivity for vascular calcium channels. (wikipedia.org)
- Bar-Or D and Gasiel Y. Calcium and calciferol antagonise effect of verapamil in atrial fibrillation. (medicalcityhospital.com)
- Reversal of the cardiovascular effects of verapamil by calcium and sodium: differences between electrophysiologic and hemodynamic responses. (medicalcityhospital.com)
- Treatment of severe left ventricular dysfunction with calcium chloride in patients receiving verapamil. (medicalcityhospital.com)
- Intravenous verapamil for treatment of multifocal atrial tachycardia with and without calcium pretreatment. (medicalcityhospital.com)
- Calcium gluconate in severe verapamil intoxication. (medicalcityhospital.com)
- Low-dose calcium pretreatment to prevent verapamil-induced hypotension. (medicalcityhospital.com)
- The calcium channel blocker that caused the greatest number of deaths in 2010 in the United States was verapamil. (wikipedia.org)
- non-dihydropyridines, or 'rate-limiting' calcium-channel blockers (for example diltiazem and verapamil). (bupa.co.uk)
- Other calcium channel blockers, including diltiazem and verapamil, are used to treat rapid heart rates and angina. (verywellhealth.com)
- Postmarketing surveillance revealed a potential serious interaction between mibefradil and beta-blockers, digoxin, verapamil, and diltiazem, especially in elderly patients. (nih.gov)
- The use of calcium salts in the prevention and management of verapamil-induced hypotension. (aafp.org)
- We share the concern for the possibility of hypotension associated with the use of intravenous calcium channel blockers, which is more common with verapamil than with diltiazem. (aafp.org)
- 3 Specifically, severe bradyarrhythmias have been reported in a 45-year-old patient receiving intravenous calcium as pretreatment for the use of intravenous verapamil. (aafp.org)
- Verapamil can interact with beta-blockers, nonsteroidal anti-inflammatory drugs, and certain heart medications. (internationaldrugmart.com)
- Factors which potentially favour use of calcium channel blockers include arrhythmia (verapamil only), angina, older age and high risk of stroke. (bpac.org.nz)
- Factors which may weigh against the use of calcium channel blockers include potential drug interactions, and diltiazem and verapamil are contraindicated in heart block and heart failure. (bpac.org.nz)
- Verapamil and diltiazem may be alternatives to beta blockers for secondary prevention post myocardial infarction if beta blockers are contraindicated or not tolerated. (bpac.org.nz)
- Verapamil can also be used post myocardial infarction if beta blockers are contraindicated or not tolerated. (bpac.org.nz)
- Taking too much calcium chamber blockers such as amlodipine , Diltiazem or verapamil. (healthtap.com)
- Verapamil Calcium Channel Blocker Drug. (123rf.com)
- AQA-39 is a new bradycardia-inducing drug chemically related to verapamil that reduces potassium conductance and blocks calcium channels. (aspetjournals.org)
- Four simple, sensitive and accurate spectrophotometric methods have been developed for the determination of some calcium channel blockers: Amlodipine besylate (ADB), Diltiazem hydrochloride (DTZ) and Verapamil hydrochloride (VPM) in pharmaceutical formulations. (scirp.org)
- Verapamil is the least selective of any calcium channel blocker, and has significant effects on both cardiac and vascular smooth muscle cells. (scirp.org)
Amlodipine5
- In the largest randomized controlled trial of treatment for high blood pressure ever conducted in sub-Saharan Africa, two frontline two-drug combinations that included the long-acting calcium channel blocker, amlodipine, were able to drive down blood pressure levels more than a third two-drug combination that did not include amlodipine, according to research presented at the American College of Cardiology's 68th Annual Scientific Session. (news-medical.net)
- The calcium channel blocker amlodipine decreases the risk of cardiovascular events (such as heart attack or heart-disease related deaths) in patients with coronary artery disease and normal blood pressure, as does the ACE inhibitor enalapril, but to a lesser extent, according to a study in the November 10 issue of JAMA. (eurekalert.org)
- dihydropyridine calcium-channel blockers (for example amlodipine, felodipine and nifedipine) which make your arteries become wider. (bupa.co.uk)
- This rapidly expanding class of calcium channel blockers includes the first-generation (nifedipine), second-generation: "amlodipine, felodipine, isradipine" and others. (scirp.org)
- Some of the newer agents, such as amlodipine and nicerdipine, have the advantage that they show little interaction with other cardiovascular drugs, such as digoxin or warfarine that are often used concomitantly with calcium channel blockers. (scirp.org)
Antagonists6
- Calcium channel blockers, also called calcium antagonists, are a newer category of medications which are used to treat heart disease and hypertension . (healthcentral.com)
- They're also called calcium antagonists. (healthline.com)
- Calcium channel blockers ( CCB ), calcium channel antagonists or calcium antagonists [2] are a group of medications that disrupt the movement of calcium ( Ca 2+ ) through calcium channels . (wikipedia.org)
- Calcium channel blockers (sometimes called calcium antagonists) are drugs that affect the way calcium passes into certain muscle cells and they are the most commonly prescribed medication for primary Raynaud's phenomenon. (cochrane.org)
- Calcium channel blockers, also known as calcium channel antagonists, are widely used for a number of health conditions. (wikipedia.org)
- Long-acting dihydropyridine calcium antagonists. (biomedsearch.com)
Medications16
- For those who suffer from angina , calcium channel blockers have proved to be among the most effective medications ever discovered. (healthcentral.com)
- Calcium channel blockers are common medications that have a low risk of complications. (medicalnewstoday.com)
- Commonly recommended medications include beta blockers, calcium channel blockers and tricyclic antidepressants. (thefreedictionary.com)
- Calcium channel blockers are medications that relax the arteries. (sharecare.com)
- [3] Calcium channel blockers are used as antihypertensive drugs , i.e., as medications to decrease blood pressure in patients with hypertension . (wikipedia.org)
- Sandee Lamotte, CNN , 26 May 2020 That might include medication (such as blood thinners, anti-seizure medications, or calcium channel blockers that can reduce some of the symptoms of Moyamoya). (merriam-webster.com)
- Calcium channel blockers may interact with other medications, so always tell your doctor about every medication, recreational drug, vitamin, and supplement - whether over-the-counter (OTC) or prescription - that you are taking. (everydayhealth.com)
- Some evidence suggests that the bioflavonoid naringen may interact with medications in the calcium channel blocker family, increasing blood levels of the drug. (medicalcityhospital.com)
- The other studied antihypertensive medications, including long-acting calcium channel blockers, did not appear associated with increased risk for pancreatic cancer. (healio.com)
- Women who had ever used short-acting calcium channel blockers demonstrated significantly lower sRAGE levels compared with those who used any other antihypertensive medications (1,158 pg/mL vs. 1,446 pg/mL, P = 0.032). (healio.com)
- Medications to treat the toxic effects include: intravenous fluids, calcium gluconate, glucagon, high dose insulin, vasopressors and lipid emulsion. (wikipedia.org)
- The three most common types of heart medications that result in this outcome are calcium channel blockers along with beta blockers and digoxin. (wikipedia.org)
- Calcium channel blockers are a class of medications that are approved to treat high blood pressure, heart failure, cardiac arrhythmias, and similar conditions. (mentalhelp.net)
- Calcium channel blockers can be used in combination with other medications to lower blood pressure. (verywellhealth.com)
- When taking calcium channel blockers, you should be certain your doctor knows about all of your current medications and supplements, because calcium channel blockers can interact with other compounds. (verywellhealth.com)
- Unfortunately, not all people with Marfan disease can tolerate these drugs and other medications called calcium channel blockers, which also lower blood pressure, are often used as an alternative. (elifesciences.org)
Drugs called calcium channel3
- Belongs to a family of drugs called calcium channel blockers. (fpnotebook.com)
- Older adults who take blood pressure drugs called calcium channel blockers could experience severe drops in blood pressure if also given antibiotics such as erythromycin (brands like E-Mycin) or clarithromycin (Biaxin), according to a new study. (mcknights.com)
- It belongs to a class of drugs called calcium channel blockers, which relax blood vessels and thus normalize heartbeats. (internationaldrugmart.com)
Different calcium channel4
- Two different calcium channel blockers were included: nifedipine and nicardipine. (cochrane.org)
- To assess the effects of different calcium channel blockers for primary Raynaud's phenomenon as determined by attack rates, severity scores, participant-preference scores and physiological measurements. (cochrane.org)
- Choice between the different calcium channel blockers depends on patient tolerability, co-morbidity and drug interactions. (bpac.org.nz)
- studied the effect of two different calcium channel blockers on mice that have a mutation in Fbn1 -the mouse equivalent of FBN1 -that is similar to those found in humans with Marfan syndrome. (elifesciences.org)
Alpha Blockers3
- While some alpha-blockers, ACE inhibitors and calcium channel blockers have more favorable short-term effects on blood glucose or blood cholesterol levels, they have been promoted over beta-blockers and diuretics to treat patients with metabolic syndrome. (mednews.com)
- ACE inhibitors and alpha-blockers) was especially marked in the black participants with metabolic syndrome,' the authors write. (mednews.com)
- These findings fail to provide support for the selection of alpha-blockers, ACE inhibitors, or calcium channel blockers over thiazide-type diuretics to prevent cardiovascular or renal outcomes in patients with metabolic syndrome, despite their more favorable metabolic profiles,' the authors conclude. (mednews.com)
20191
- Voltage-Dependent T-Type Calcium Channel Blockers - Pipeline Insight, 2019" offers comprehensive insights of the pipeline (under development) therapeutics scenario and growth prospects across "Voltage-Dependent T-Type Calcium Channel Blockers development. (reportbuyer.com)
Amount of calcium5
- Calcium channel blockers reduce the amount of calcium that can enter muscle cells in the heart and blood vessel walls via these channels. (medicalnewstoday.com)
- The researchers used fruit flies to study AD, using a fluorescent molecule called GCaMP6f, which reports the amount of calcium ions inside brain cells. (bris.ac.uk)
- Calcium-channel blockers slow down the amount of calcium that can get into heart muscle cells and so reduce how fast and strongly it can contract. (bupa.co.uk)
- Calcium channel blockers work by reducing the amount of calcium that flows into the heart muscle cells and the cell walls of the arteries. (verywellhealth.com)
- While high doses of intravenous calcium are sometimes used to reverse an overdose of a calcium-channel blocker, the amount of calcium in a daily supplement isn't enough to interfere with the drug's ability to lower blood pressure. (harvard.edu)
Diuretic14
- The recommendations for the treatment of hypertension in black people suggest beginning initial blood pressure treatment with a calcium channel blocker or a thiazide-type diuretic, even in patients with diabetes. (verywellhealth.com)
- Combining an ACE inhibitor with a calcium channel blocker more effectively reduces the risk of cardiovascular events than an ACE inhibitor with a diuretic, a major new trial concludes. (pulsetoday.co.uk)
- Current guidance from NICE and the British Hypertension Society recommends combining a calcium channel blocker or a diuretic with an ACE inhibitor as second-line treatment of hypertension, but the best combination has not been established. (pulsetoday.co.uk)
- But the ACCOMPLISH study, of more than 11,000 hypertensive patients at high risk of cardiovascular events, found treatment with an ACE inhibitor plus a calcium-channel blocker produced better outcomes than an ACE inhibitor plus a diuretic. (pulsetoday.co.uk)
- Mean blood pressure in the calcium channel blocker group was 131.6/73.3 mmHg, compared with 132.5/74.7 mm Hg in the diuretic group. (pulsetoday.co.uk)
- The calcium channel blocker group also had fewer recorded adverse events, with a total of 552 (9.6%), compared with 679 (11.8%) with the diuretic. (pulsetoday.co.uk)
- Patients treated with an ACE inhibitor and a calcium channel blocker were 21% less likely to suffer a cardiovascular disease-related death or non-fatal heart attack or stroke than those in the diuretic group. (pulsetoday.co.uk)
- 5 Amongst those receiving combination therapy (usually a beta blocker or diuretic), no increase in risk was observed. (nps.org.au)
- A diuretic or calcium channel blocker is recommended as the first drug treatment for older adults with isolated systolic hypertension (high systolic blood pressure with normal diastolic blood pressure). (sharecare.com)
- Morbidity and mortality in patients randomised to double-blind treatment with a long-acting calcium-channel blocker or diuretic in the Internationa. (nih.gov)
- Morbidity and mortality in patients randomised to double-blind treatment with a long-acting calcium-channel blocker or diuretic in the International Nifedipine GITS study: Intervention as a Goal in Hypertension Treatment (INSIGHT). (nih.gov)
- We compared the effects of the calcium-channel blocker nifedipine once daily with the diuretic combination co-amilozide on cardiovascular mortality and morbidity in high-risk patients with hypertension. (nih.gov)
- 42,418 hypertension patients with at least one other risk factor for heart disease were randomly picked to take either a diuretic (chlorthalidone -15,255 patients), a calcium channel blocker (doxazosin mesylate - 9,061 patients), or an ACE inhibitor (lisinopril - 9,054 patients). (mednews.com)
- Similar higher risk was noted for those randomized to the alpha-blocker vs. the diuretic. (mednews.com)
Overdose6
- Calcium-channel blocker overdose occurs when someone takes more than the normal or recommended amount of this medicine. (medlineplus.gov)
- Along with beta blockers and digoxin calcium channel blockers have one of the highest rates of death in overdose. (wikipedia.org)
- It may not be possible to tell the difference between beta blocker toxicity and calcium channel blocker overdose based on signs and symptoms. (wikipedia.org)
- Overdose with calcium channel blockers can have life-threatening effects on heart rate, blood pressure and respiratory functions. (lortsmith.com)
- What the heck is calcium channel blocker overdose really? (healthtap.com)
- Explain the problem of a calcium channel blocker overdose. (healthtap.com)
Angiotensin9
- One drug, an angiotensin-converting enzyme (ACE) inhibitor, has proven effective in preventing progression to stages IV and V Calcium channel blockers , another class of antihypertensive drugs, also show promise. (thefreedictionary.com)
- Angiotensin II inhibitors with calcium channel blocking agents is a combination medicine containing both an angiotensin II inhibitor and a calcium channel blocker. (drugs.com)
- Furberg, national chairman of CHS Steering Committee, said they found more evidence of brain damage and lower scores on a standard mental test in participants taking calcium channel blockers or so-called "loop" diuretics -- such as Lasix -- than in those using beta blockers, so-called ACE (angiotensin-converting enzyme) inhibitors -- such as Enalapril -- or thiazide diuretics. (eurekalert.org)
- The investigators assessed four types of antihypertensive drugs: beta blockers, diuretics, angiotensin converting enzyme inhibitors and calcium channel blockers. (healio.com)
- But research shows that calcium channel blockers, diuretics, ACE inhibitors, and angiotensin receptor blockers are all equally effective for older adults. (sharecare.com)
- Atacand ( candesartan ) is an angiotensin receptor blocker. (healthtap.com)
- Benicar ( olmesartan ) is not a calcium blocker it is an angiotensin receptor blocker. (healthtap.com)
- No. It's an angiotensin receptor blocker. (healthtap.com)
- Which stands for angiotensin receptor blockers. (healthtap.com)
Diuretics and beta-blockers2
- When nifedipine was used in combination with other drugs (diuretics and beta-blockers) it seemed to have a safety advantage," says lead author, William Stason, M.D. He is a lecturer in health policy management at the Harvard School of Public Health and consultant to Meta Works, Inc., a Boston group that generated the study. (eurekalert.org)
- The efficacy of antihypertensive drugs newer than diuretics and beta-blockers has not been established. (nih.gov)
Medication14
- Calcium channel blockers are a type of medication that people take to increase the flow of blood and oxygen to the heart. (medicalnewstoday.com)
- Several other types of medication have an effect similar to that of calcium channel blockers. (medicalnewstoday.com)
- If your neurologist does end up putting you on a blood pressure medication, and it turns out to be a Calcium Channel Blocker instead of a Beta Blocker. (medhelp.org)
- After adjustment for demographics, comorbidities, and the use of other sorts of medication, mortality from breast cancer was no higher in women who had taken calcium channel blockers than in women who had never used them. (bmj.com)
- A type of blood pressure lowering medication, called a calcium-channel blocker, may be linked with an increased risk of a type of bowel condition called diverticulosis. (news-medical.net)
- Calcium Channel Blockers also lower blood pressure so it often given in blood pressure medication but it can also prevent Engina or the symptoms of the blocked artery. (sharecare.com)
- Recent Examples on the Web Those preventative medicine treatments include anticonvulsants, antidepressants, beta blockers and calcium channel blockers that might help control withdrawal pain without risking medication overuse headaches. (merriam-webster.com)
- Alcohol, combined with a calcium channel blocker, can cause severe side effects and may also affect the way the medication works. (everydayhealth.com)
- Calcium channel blockers are generally safe, but like any medication, need to be taken properly and with care. (everydayhealth.com)
- Calcium channel blockers are a common class of medication used to treat high blood pressure and heart arrhythmias (irregular heartbeats. (verywellhealth.com)
- Calcium channel blockers are sometimes prescribed in combination forms with a statin or another blood pressure medication. (verywellhealth.com)
- If you are taking a calcium channel blocker, you should wait at least four hours after taking the medication before consuming grapefruit or grapefruit juice. (verywellhealth.com)
- Lercanidipine is a medication that is classified as a calcium channel blocker: drugs that dilate blood vessels and lower blood pressure. (dokteronline.com)
- Is there calcium channel blockers in the medication benicar (olmesartan) thanks? (healthtap.com)
Cardiac6
- They prevent the calcium ions needed for muscle contraction from entering the cells of smooth and cardiac muscle. (factmonster.com)
- Inhibits transmembrane calcium influx (prevents calcium from entering cells) in cardiac (heart) and vascular smooth muscle (blood vessel walls). (exrx.net)
- Any of a class of drugs that inhibit the movement of calcium ions across the cell membranes of cardiac and smooth muscle and are used to treat cardiovascular disorders. (thefreedictionary.com)
- Medicine) any drug that prevents the influx of calcium ions into cardiac and smooth muscle: used to treat high blood pressure and angina. (thefreedictionary.com)
- Calcium channel blockers are medicates that relax the arteries, says Mary Ann McLaughlin, MD, medical director of the Cardiac Health Program at The Mount Sinai Medical Center. (sharecare.com)
- Hence, as the calcium level continues to drop, the patient begins to experience muscle twitching and cramping, grimacing, and carpopedal spasm, which can quickly progress to tetany, laryngospasm, convulsions, cardiac arrhythmias, and eventually to respiratory and cardiac arrest. (thefreedictionary.com)
Dihydropyridines4
- There are two different types of calcium channel blocker, which are called dihydropyridines and nondihydropyridines. (medicalnewstoday.com)
- Dihydropyridines target a specific type of calcium channel in the body. (medicalnewstoday.com)
- Benzothiazepine calcium channel blockers belong to the benzothiazepine class of compounds and are an intermediate class between phenylalkylamine and dihydropyridines in their selectivity for vascular calcium channels. (wikipedia.org)
- Dihydropyridines are used to treat high blood pressure, more frequently than the other classes of calcium channel blocker. (verywellhealth.com)
Cardiovascular4
- Long-acting calcium channel blockers are significantly less effective than other antihypertensive agents in reducing the disease's major cardiovascular complications, according to a new metaanalysis. (thefreedictionary.com)
- Calcium channel blockers have been implicated in problems with cardiovascular diseases, cancer, and unexplained stomach and intestinal bleeding. (eurekalert.org)
- They share this quality with major therapeutic agents such as dihydropyridine-type calcium channel blockers ( Godfraind, 2004 ) that are established drugs for treating cardiovascular diseases. (frontiersin.org)
- the ACE inhibitor and the alpha-blocker also had an increased risk of combined cardiovascular disease. (mednews.com)
Blood43
- They block the small pores in cells that let calcium pass through, and widen blood vessels as well as affect the activity of nerve cells. (webmd.com)
- They can slow the heart rate and relax blood vessels and they work by diminishing the flow of calcium between cells. (healthcentral.com)
- Doctors may prescribe a calcium channel blocker to treat high blood pressure or a variety of heart conditions. (medicalnewstoday.com)
- Doctors commonly use calcium channel blockers to treat high blood pressure . (medicalnewstoday.com)
- For example, by reducing high blood pressure, they believe that calcium channel blockers may be able to lower the risk of Alzheimer's disease . (medicalnewstoday.com)
- Researchers have found that both beta-blockers and calcium channel blockers are effective in lowering blood pressure, making them useful treatments for a variety of conditions that affect the heart, including angina and arrhythmia. (medicalnewstoday.com)
- However, the American Heart Association recommend calcium channel blockers as a first-line pharmacological treatment for high blood pressure in most people and advise that beta-blockers should be a second-choice option. (medicalnewstoday.com)
- That's good to know though about the Calcium Channel Blockers lowering blood pressure. (medhelp.org)
- They tried all the preventatives on me, Imipramine(anti-depressant), Nadolol ( beta blocker) and a few others nothing worked so we thought we had to do something as I have had a migraine now for months---from about the 5th Oct till yesterday I was migraine free with the Diltiazem CD (calcium blocker for blood pressure), so it does help me. (medhelp.org)
- When calcium flow is limited, your heart's contractions aren't as strong with each beat, and your blood vessels are able to relax. (healthline.com)
- How do calcium channel blockers work for high blood pressure? (webmd.com)
- Calcium-channel blockers are a type of medicine used to treat high blood pressure and heart rhythm disturbances. (medlineplus.gov)
- Some calcium channel blockers slow heart rate, which can further reduce blood pressure, relieve chest pain (angina) and control an irregular heartbeat. (exrx.net)
- Benoff has for many years investigated whether calcium channel blockers commonly prescribed for high blood pressure and heart disease can serve as male contraceptives. (thefreedictionary.com)
- in the diabetic, beta blockers should be replaced by calcium channel blockers for angina or high blood pressure. (thefreedictionary.com)
- Calcium channel blockers block calcium from entering cells of the heart and smooth muscle in the walls of blood vessels. (drugs.com)
- NBC News , 9 July 2018 Among the 4,338 women who had taken a short-acting calcium channel blocker for high blood pressure, 45 (or about 1%) were diagnosed with pancreatic cancer. (merriam-webster.com)
- Calcium channel blockers are prescribed for high blood pressure and heart problems, but be careful when using one with diuretics, ACE inhibitors, or other drugs. (everydayhealth.com)
- Calcium channel blockers are a class of drugs prescribed for high blood pressure and other heart diseases. (everydayhealth.com)
- Calcium channel blockers reduce the speed at which calcium moves into heart muscle, blood vessels, and cells in the heart that control your heart rate. (everydayhealth.com)
- Calcium channel blockers relax and widen blood vessels. (cigna.com)
- Calcium channel blockers are used to lower high blood pressure . (cigna.com)
- Calcium channel blockers lower blood pressure and help prevent a heart attack or stroke. (cigna.com)
- Calcium channel blockers can lower blood pressure or slow the heart rate. (northshore.org)
- DALLAS, July 7 -- Boston researchers say they have evidence that supports the safety of nifedipine, a calcium channel blocker used to treat high blood pressure. (eurekalert.org)
- Calcium channel blockers have been used for decades to treat high blood pressure. (eurekalert.org)
- Most people who have taken too much of a calcium channel blocker, especially diltiazem, get slow heart rate and low blood pressure (vasodilatory shock). (wikipedia.org)
- Calcium plays a key role in how the muscles in your heart and arteries contract to pump blood round your body. (bupa.co.uk)
- Calcium-channel blockers restrict how much calcium can enter the muscle cells in your blood vessels. (bupa.co.uk)
- The research of all available evidence by JNC 8 (Joint National Commission 8) has demonstrated an advantage to the use of calcium channel blockers in certain groups, particularly for the initial treatment of high blood pressure in African-American people. (verywellhealth.com)
- Calcium channel blockers, also called calcium channel antagonist or calcium antagonist, are drugs that prevent calcium from entering muscle cells of the heart and walls of blood vessels. (alleydog.com)
- Q. My doctor started me on a calcium-channel blocker for high blood pressure. (harvard.edu)
- In fact, in some people, an oral calcium supplement actually lowers blood pressure around one or two points. (harvard.edu)
- Since the effect is so small, oral calcium isn't recommended for treating high blood pressure. (harvard.edu)
- Calcium channel blockers may be used in people with coronary artery disease to lower their blood pressure. (wellspan.org)
- Parathyroid hormone, which causes transfer of exchangeable calcium from bone into the blood stream, maintains calcium homeostasis by preventing either calcium deficit or excess. (thefreedictionary.com)
- I read this on Michael J Fox's Parkinson's web site about people taking Calcium Channel Blockers but not other type of High Blood Pressure Meds lowered their risks of Paekinson's. (city-data.com)
- Who should take a calcium channel blocker for high blood pressure? (sharecare.com)
- Calcium channel blockers and diuretics are often considered good treatment choices for older people with high blood pressure. (sharecare.com)
- Calcium channel blockers can be used as a second-line drug treatment or as an alternative to beta blockers for people with high blood pressure and stable angina. (sharecare.com)
- Calcium channel blockers improve the flow of blood in narrowed arteries. (sharecare.com)
- Other drugs could be added if necessary to control blood pressure, and patients were checked for an average of 4.9 years for all drugs administered except the alpha-blocker. (mednews.com)
- It is thought that calcium channel blockers help reduce stress on blood vessels, but there is little data to show whether these drugs are safe and helpful for patients with Marfan syndrome. (elifesciences.org)
Mechanism7
- [ 71 ] The presumed mechanism of action is through calcium antagonism. (medscape.com)
- We report for the first time the results of an electrophysiologic study of a similar case and the successful use of calcium channel blockers, shedding light on the possible mechanism and management of these patients. (springer.com)
- The mechanism of action underlying ziconotide's therapeutic profile derives from its potent and selective blockade of neuronal N-type voltage-sensitive calcium channels (NVSCCs). (ingentaconnect.com)
- Their mechanism of action in tocolysis involves the blockade of L-type Ca 2+ channels, influenced by the Ca 2+ -activated K + channels, beta-adrenergic receptors (β-ARs) and sexual hormones. (mdpi.com)
- Blockade of Cav2.2 (N-type) channels has previously been shown to prevent pain transmission and activity against this channel has been proposed as the mechanism of action of Ziconotide, a neuroactive peptide developed by Elan as a novel non-opioid treatment for severe chronic pain. (pharmiweb.com)
- Voltage-Dependent Calcium Channel Blockers - Pipeline Insight, 2020" report by DelveInsight outlays comprehensive insights of present scenario and growth prospects across the mechanism of action. (reportsnreports.com)
- A detailed picture of the Voltage-Dependent Calcium Channel Blockers pipeline landscape is provided, which includes the topic Overview and Voltage-Dependent Calcium Channel Blockers mechanism of action. (reportsnreports.com)
Placebo4
- The WMD of all calcium-channel blockers versus placebo (6 trials) and of nifedipine alone versus placebo (5 trials) for the reduction in the frequency of ischemic attacks over a 2-week period was -8.31 (95% confidence interval [95% CI] -15.71, -0.91) and -10.21 (95% CI -20.09, -0.34), respectively. (nih.gov)
- The SMD of all calcium-channel blockers versus placebo (3 trials) and of nifedipine alone versus placebo (2 trials) for the reduction in the severity of ischemic attacks was -0.69 (95% CI -1.21, -0.17) and -0.99 (95% CI -1.74, -0.24), respectively. (nih.gov)
- A randomized double-blind, placebo-, and active-controlled study of T-type calcium channel blocker ABT-639 in patients with diabetic peripheral neu. (nih.gov)
- Patients randomized to the control group received either placebo or active treatment with ACE-inhibitors, beta-blockers or diuretics. (ahajournals.org)
Vascular3
- Dihydropyridine (DHP) calcium channel blockers are derived from the molecule dihydropyridine and often used to reduce systemic vascular resistance and arterial pressure. (wikipedia.org)
- Inhibition of vascular calcium-gated chloride currents by blockers of KCa1.1, but not by modulators of KCa2.1 or KCa2.3 channels. (sigmaaldrich.com)
- They block the channel which gets calcium into cells so that the calcium needed for smooth muscle function is blocked resulting in decreased vascular resistance. (healthtap.com)
Take calcium channel3
- Who should take calcium channel blockers? (healthline.com)
- You should not, however, take calcium channel blockers with grapefruit juice or grapefruit. (everydayhealth.com)
- Remember to take calcium channel blockers exactly as your doctor or pharmacist recommends. (everydayhealth.com)
Procardia1
- Some calcium-channel blockers, such as Procardia (nifedipine), slow the electrical impulses that run through heart muscle, thus regulating arrhythmias. (factmonster.com)
Inhibition2
- Since lymphatic drainage relies on contraction of the smooth muscle inside the lymphatic vessel supported by voltage-gated calcium channels, inhibition of voltage-gated calcium channel poses a threat towards lymphatic removal of interstitial fluid essential for normal lymphatic system functioning. (wikipedia.org)
- A class of drugs that act by selective inhibition of calcium influx through cell membranes or on the release and binding of calcium in intracellular pools. (jove.com)
Antihypertensive agents1
- Posicor has a long half-life of 17 to 25 hours and a prolonged washout period may be required after discontinuation of the calcium channel blocker prior to initiation of other antihypertensive agents. (mercola.com)
Angina pectoris3
- calcium-channel blocker, any of a class of drugs used in treating hypertension , angina pectoris , and certain arrhythmias . (factmonster.com)
- [4] Calcium channel blockers are also frequently used to alter heart rate (especially from atrial fibrillation), to prevent peripheral and cerebral vasospasm , and to reduce chest pain caused by angina pectoris . (wikipedia.org)
- However, two large studies in the past five years have generated concerns that they may be dangerous for some individuals, The two studies included an investigation that pooled data from 15 trials involving about 10,000 patients with unstable angina pectoris or heart attack and found an increase in deaths among patients taking a short-acting form of the calcium channel blocker nifedipine. (eurekalert.org)
Role of calcium channel1
- What is the role of calcium channel blockers in urinary incontinence treatment? (medscape.com)
Effect of calcium channel4
- The beneficial effect of calcium channel blockers is mediated via their peripheral vasodilatory, antiplatelet, and antileukocytic effects. (thefreedictionary.com)
- My concern is the hypotensive effect of calcium channel blockers, especially in elderly patients in whom atrial fibrillation is more common. (aafp.org)
- There is some evidence of a superior protective effect of calcium channel blockers in people with a high risk of stroke when compared with other antihypertensives. (bpac.org.nz)
- Age and ethnicity have less influence on the antihypertensive effect of calcium channel blockers compared with other agents (e.g. (bpac.org.nz)
Safety of calcium-channel1
- Massie BM (1998) The safety of calcium-channel blockers. (exrx.net)
Classes of calcium channel1
- An atomic level analysis has revealed how two classes of calcium channel blockers, widely prescribed for heart disease patients, produce separate therapeutic effects through their actions at different sites on the calcium channel molecule. (news-medical.net)
Inhibit3
- This report reviews the experimental evidence from animal and human studies, both in vitro and in vivo, that the calcium channel blockers inhibit bronchoconstriction. (ingentaconnect.com)
- Zipes DP, Fischer JC (1974) Effects of agents which inhibit the slow channel on sinus node automaticity and atrioventricular conduction in the dog. (springer.com)
- Coating such devices with calcium channel blockers to inhibit proliferation may provide a delivery platform to minimise restenosis. (strath.ac.uk)
Bipolar disorder3
- Research suggests that the way the brain uses calcium to regulate nerve cells may not work right in some people with bipolar disorder. (webmd.com)
- So calcium channel blockers have been studied as a treatment for bipolar disorder, but there isn't enough evidence yet that they work. (webmd.com)
- Which calcium channel blockers have been studied to treat bipolar disorder? (webmd.com)
Modulators1
- Zalicus applies its expertise in the discovery and development of selective ion channel modulators and its combination high throughput screening capabilities to discover innovative therapeutics for itself and its collaborators in the areas of pain, inflammation, oncology and infectious disease. (aol.com)
Heart16
- It flows between the heart cells and surrounding fluid through a sort of chemical revolving door - the calcium channel. (healthcentral.com)
- The more calcium that gets through the door before the electrical signal comes, the more strongly the heart contracts and the harder it works. (healthcentral.com)
- Beta-blockers slow heart activity by limiting the effects of stress hormones, such as epinephrine and norepinephrine. (medicalnewstoday.com)
- Calcium stimulates the heart to contract more forcefully. (healthline.com)
- Calcium channel blockers are typically used to treat hypertension and have been viewed with caution in the United States since 1995, when the initial findings of several scattered studies found a possible link to heart attacks, strokes, cancer, gastrointestinal bleeding, and perhaps even Parkinson's disease, according to Brant S. (thefreedictionary.com)
- Video / Heart Health / Angina / What Are Calcium Channel Blockers? (sharecare.com)
- Furberg said the results are part of a pattern of problems with calcium channel blockers that began to emerge with a report at an American Heart Association meeting in March 1995 by Bruce M. Psaty, M.D., Ph.D., of the University of Washington and Furberg. (eurekalert.org)
- Studies show that patients taking calcium channel blockers over a long period have an increase in heart attacks and strokes and in deaths from all causes. (eurekalert.org)
- Calcium channel-blockers are used to treat hypertension , angina , heart arrhythmias , and other heart-related conditions. (medicalcityhospital.com)
- Calcium-channel blockers are medicines that work on the muscle cells of your heart and your arteries. (bupa.co.uk)
- Calcium-channel blockers also prevent angina by widening the coronary arteries that supply your heart. (bupa.co.uk)
- Calcium causes the forceful contraction of muscles in the heart and it also causes constriction of the muscles in the walls of the artery. (verywellhealth.com)
- Calcium channel blockers can also lower the heart rate and decrease the heart's pumping action. (verywellhealth.com)
- The sudden withdrawal of beta blockers can rapidly increase heart rate and lead to unstable angina . (healthtap.com)
- Most calcium channel blockers decrease the force of contraction of the ________ (muscle of the heart). (thefullwiki.org)
- Calcium channel blockers do not actually cure any heart disease but are usually used to control the heart rate or the rhythm. (healthtap.com)
Chloride2
- Intravenous calcium gluconate or calcium chloride is considered a specific antidotes. (wikipedia.org)
- Others recommend 200 mg of calcium chloride (2 mL of a 10 percent solution). (aafp.org)
20161
- Juliana Quero Reimão, Juliana Tonini Mesquita, Daiane Dias Ferreira, and Andre Gustavo Tempone, "Investigation of Calcium Channel Blockers as Antiprotozoal Agents and Their Interference in the Metabolism of Leishmania (L.) infantum ," Evidence-Based Complementary and Alternative Medicine , vol. 2016, Article ID 1523691, 9 pages, 2016. (hindawi.com)
Relax2
- Without calcium, the muscles relax and the arteries dilate. (healthcentral.com)
- So some people have a spasm in their artery, calcium channel blocker as a joint is more likely to relax that and prevent that from happening. (sharecare.com)
Reduce sRAGE release1
- The blockage caused by the use of calcium channel blockers may reduce sRAGE release and cause chronic inflammation, a known risk factor for pancreatic cancer and other cancer types. (healio.com)
Therapeutic5
- T-type calcium channels have been recognized as key targets for therapeutic intervention in a broad range of cell functions and have been implicated in pain signaling. (aol.com)
- The naturally occurring ù-conotoxins have activity at various Ca channels including the N- (Cav2.2), P/Q- (Cav2.1), R- (Cav2.3), and T- (Cav3.1/3.2) type channels and have served as platforms for the development of therapeutic agents now in development. (pharmiweb.com)
- Different therapeutic candidates in early-stage, mid-stage and late stage of development for Voltage-Dependent Calcium Channel Blockers. (reportsnreports.com)
- The Voltage-Dependent Calcium Channel Blockers report provides an Overview of therapeutic pipeline activity and therapeutic assessment of the products by development stage, product type, route of administration, molecule type, and MOA the complete product development cycle, including all clinical and nonclinical stages. (reportsnreports.com)
- It comprises of detailed profiles of Voltage-Dependent Calcium Channel Blockers therapeutic products with key coverage of involved technology, collaborations, licensing, mergers and acquisition, funding, designations and other product-related details. (reportsnreports.com)
Dihydropyridine calcium2
- Dihydropyridine calcium channel blockers can worsen proteinuria in patients with nephropathy . (wikipedia.org)
- These images are a random sampling from a Bing search on the term "Dihydropyridine Calcium Channel Blocker. (fpnotebook.com)
Patients with hypertension2
- Many patients with hypertension have benefited from calcium channel blockers. (healthcentral.com)
- Based on the results of this study, calcium-channel blockers appear to be effective in the prevention of PAD in patients with hypertension. (ahajournals.org)
Beta13
- Examples of beta-blockers include atenolol (Tenormin) and metoprolol (Lopressor). (medicalnewstoday.com)
- I don't know if the neurologist was talking about beta blockers or calcium channel blockers. (medhelp.org)
- I had tried beta blockers, tricycline without success. (medhelp.org)
- From what I understand-beta blockers don't lower the BP, that is what my GP told me, it is the calcium channel blockers that will lower BP. (medhelp.org)
- This was initiated after a presentation of data which compared relative mortality of beta-blockers and calcium blockers. (druginfonet.com)
- David Becker, Philly.com , 12 June 2018 Beta blockers may reduce the frequency and severity of migraines, and calcium channel blockers can help prevent migraines altogether, according to the Mayo Clinic. (merriam-webster.com)
- The results of our meta-analysis lend support to the safety of sustained-release and extended-release formulations of nifedipine in the treatment of hypertension, when they are used in combination with diuretics or beta blockers," he says. (eurekalert.org)
- The first of these was a case-control study which revealed that patients taking calcium channel blockers had a higher risk of myocardial infarction than those taking diuretics (risk ratio 1.62) or beta blockers (risk ratio 1.57). (nps.org.au)
- β-blocker ( beta-blocker ) beta-adrenergic blocking agent . (thefreedictionary.com)
- They are constantly gaining in importance, and increasingly more significant than traditional tocolytics such as beta-adrenergic receptor (β-AR) blockers or magnesium sulphate. (mdpi.com)
- How are calcium channel blockers and beta blockers different? (healthtap.com)
- The calcium blockers block the calcium channel plugs and the beta blockers block the beta receptor plugs. (healthtap.com)
- Other classes of pharmaceutical agents that have overlapping effects as calcium channel blockers include ________ , beta-blockers , and nitrates. (thefullwiki.org)
Ions6
- The team's findings, published in Frontiers in Cellular Neuroscience , found treating a diseased brain cell with a blocker of the L-type channel reduced the number of calcium ions able to flow into the brain cell. (bris.ac.uk)
- They found that diseased brain cells become overloaded with calcium ions, which at normal levels are important for memory formation. (bris.ac.uk)
- This overload was due to the overproduction of the gene encoding a channel, known as the L-type channel, which allows calcium ions to flow into the cell from outside. (bris.ac.uk)
- More of these channels means more calcium ions are able to flow into the cell, disrupting memory formation. (bris.ac.uk)
- Using a drug to block the L-type channel reversed the effect of disease and reduced the flow of calcium ions to a normal level. (bris.ac.uk)
- However, if the overproduction of L-type channels was corrected in the diseased flies, their brain cells were no longer overloaded with calcium ions and their memory was just as good as healthy flies. (bris.ac.uk)
Myocardial2
- The calcium channel blockers are a group of drugs which impede calcium ion entry into cells, thereby inhibiting myocardial and smooth muscle contraction, as well as various secretory processes. (ingentaconnect.com)
- Phenylalkylamine calcium channel blockers are relatively selective for myocardium, reduce myocardial oxygen demand and reverse coronary vasospasm, and are often used to treat angina. (wikipedia.org)
Selective blockers1
- Gabapentinoids , such as gabapentin and pregabalin , are selective blockers of α2δ subunit -containing voltage-gated calcium channels . (wikipedia.org)
Commonly3
- Calcium channel blockers are the most commonly prescribed drugs for people with primary Raynaud's phenomenon. (cochrane.org)
- Can you tell me commonly prescribed calcium channel blocker recommended by aha? (healthtap.com)
- What are commonly prescribed calcium channel blockers? (healthtap.com)
Digoxin1
- 1 I'm glad that it has become universally accepted that calcium channel blockers are excellent first-line therapy for ventricular rate control, and that digoxin should only be used adjunctively because it is less effective. (aafp.org)
Pancreatic cancer risk1
- Our findings on short-acting calcium channel blocker use and pancreatic cancer risk are novel and of potential broad medical and public health significance if confirmed," Wang said in a press release. (healio.com)
Antagonist1
- However, the main ingredient is called a calcium-channel antagonist. (medlineplus.gov)
Intracellular2
- There has been some anxiety that calcium channel blockers might encourage growth of malignant cells by reducing intracellular calcium concentrations and inhibiting apoptotic gene expression. (bmj.com)
- Phenylalkylamines are thought to access calcium channels from the intracellular side, although the evidence is somewhat mixed. (wikipedia.org)