Calcium binding proteins. Medical search

A calbindin protein found in many mammalian tissues, including the UTERUS, PLACENTA, BONE, PITUITARY GLAND, and KIDNEYS. In intestinal ENTEROCYTES it mediates intracellular calcium transport from apical to basolateral membranes via calcium binding at two EF-HAND MOTIFS. Expression is regulated in some tissues by VITAMIN D.

Proteins to which calcium ions are bound. They can act as transport proteins, regulator proteins, or activator proteins. They typically contain EF HAND MOTIFS.

Calcium-binding proteins that are found in DISTAL KIDNEY TUBULES, INTESTINES, BRAIN, and other tissues where they bind, buffer and transport cytoplasmic calcium. Calbindins possess a variable number of EF-HAND MOTIFS which contain calcium-binding sites. Some isoforms are regulated by VITAMIN D.

A calcium-binding protein that mediates calcium HOMEOSTASIS in KIDNEYS, BRAIN, and other tissues. It is found in well-defined populations of NEURONS and is involved in CALCIUM SIGNALING and NEURONAL PLASTICITY. It is regulated in some tissues by VITAMIN D.

A calbindin protein that is differentially expressed in distinct populations of NEURONS throughout the vertebrate and invertebrate NERVOUS SYSTEM, and modulates intrinsic neuronal excitability and influences LONG-TERM POTENTIATION. It is also found in LUNG, TESTIS, OVARY, KIDNEY, and BREAST, and is expressed in many tumor types found in these tissues. It is often used as an immunohistochemical marker for MESOTHELIOMA.

Low molecular weight, calcium binding muscle proteins. Their physiological function is possibly related to the contractile process.

A family of highly acidic calcium-binding proteins found in large concentration in the brain and believed to be glial in origin. They are also found in other organs in the body. They have in common the EF-hand motif (EF HAND MOTIFS) found on a number of calcium binding proteins. The name of this family derives from the property of being soluble in a 100% saturated ammonium sulfate solution.

Calcium-binding motifs composed of two helices (E and F) joined by a loop. Calcium is bound by the loop region. These motifs are found in many proteins that are regulated by calcium.

A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.

A heat-stable, low-molecular-weight activator protein found mainly in the brain and heart. The binding of calcium ions to this protein allows this protein to bind to cyclic nucleotide phosphodiesterases and to adenyl cyclase with subsequent activation. Thereby this protein modulates cyclic AMP and cyclic GMP levels.

A neuronal calcium-sensor protein that is found in ROD PHOTORECEPTORS and CONE PHOTORECEPTORS. It interacts with G-PROTEIN-COUPLED RECEPTOR KINASE 1 in a Ca2+ dependent manner and plays an important role in PHOTOTRANSDUCTION.

A 13.2-kDa member of the S-100 family of calcium-binding proteins that can form homo- or heterocomplexes with CALGRANULIN A and a variety of other proteins. The calgranulin A/B heterodimer is known as LEUKOCYTE L1 ANTIGEN COMPLEX. Calgranulin B is expressed at high concentrations in GRANULOCYTES during early monocyte differentiation, and serum calgranulin B levels are elevated in many inflammatory disorders such as CYSTIC FIBROSIS.

Acidic protein found in SARCOPLASMIC RETICULUM that binds calcium to the extent of 700-900 nmoles/mg. It plays the role of sequestering calcium transported to the interior of the intracellular vesicle.

A 10.8-kDa member of the S-100 family of calcium-binding proteins that can form homo- or heterocomplexes with CALGRANULIN B and a variety of other proteins. The calgranulin A/B heterodimer is known as LEUKOCYTE L1 ANTIGEN COMPLEX. Calgranulin A is found in many cell types including GRANULOCYTES; KERATINOCYTES; and myelomonocytes, and has been shown to act as a chemotactic substance for NEUTROPHILS. Because it is present in acute inflammation but absent in chronic inflammation, it is a useful biological marker for a number of pathological conditions.

A genus of European newts in the Salamandridae family. The two species of this genus are Salamandra salamandra (European "fire" salamander) and Salamandra atra (European alpine salamander).

A nonfluorescent reagent for the detection of primary amines, peptides and proteins. The reaction products are highly fluorescent.

Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.

Signal transduction mechanisms whereby calcium mobilization (from outside the cell or from intracellular storage pools) to the cytoplasm is triggered by external stimuli. Calcium signals are often seen to propagate as waves, oscillations, spikes, sparks, or puffs. The calcium acts as an intracellular messenger by activating calcium-responsive proteins.

The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.

A nitrocellulose solution in ether and alcohol. Collodion has a wide range of uses in industry including applications in the manufacture of photographic film, in fibers, in lacquers, and in engraving and lithography. In medicine it is used as a drug solvent and a wound sealant.

The parts of a macromolecule that directly participate in its specific combination with another molecule.

The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.

Unstable isotopes of calcium that decay or disintegrate emitting radiation. Ca atoms with atomic weights 39, 41, 45, 47, 49, and 50 are radioactive calcium isotopes.

A species of parasitic protozoa causing ENTAMOEBIASIS and amebic dysentery (DYSENTERY, AMEBIC). Characteristics include a single nucleus containing a small central karyosome and peripheral chromatin that is finely and regularly beaded.

Voltage-dependent cell membrane glycoproteins selectively permeable to calcium ions. They are categorized as L-, T-, N-, P-, Q-, and R-types based on the activation and inactivation kinetics, ion specificity, and sensitivity to drugs and toxins. The L- and T-types are present throughout the cardiovascular and central nervous systems and the N-, P-, Q-, & R-types are located in neuronal tissue.

A chelating agent relatively more specific for calcium and less toxic than EDETIC ACID.

The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.

A network of tubules and sacs in the cytoplasm of SKELETAL MUSCLE FIBERS that assist with muscle contraction and relaxation by releasing and storing calcium ions.

The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain).

Calcium compounds used as food supplements or in food to supply the body with calcium. Dietary calcium is needed during growth for bone development and for maintenance of skeletal integrity later in life to prevent osteoporosis.

The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.

The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.

Contractile tissue that produces movement in animals.

Measurement of the intensity and quality of fluorescence.

Proteins that bind to the 3' polyadenylated region of MRNA. When complexed with RNA the proteins serve an array of functions such as stabilizing the 3' end of RNA, promoting poly(A) synthesis and stimulating mRNA translation.

The degree of similarity between sequences of amino acids. This information is useful for the analyzing genetic relatedness of proteins and species.

Stable calcium atoms that have the same atomic number as the element calcium, but differ in atomic weight. Ca-42-44, 46, and 48 are stable calcium isotopes.

RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.

One of the three polypeptide chains that make up the TROPONIN complex of skeletal muscle. It is a calcium-binding protein.

Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.

The physiologically active form of vitamin D. It is formed primarily in the kidney by enzymatic hydroxylation of 25-hydroxycholecalciferol (CALCIFEDIOL). Its production is stimulated by low blood calcium levels and parathyroid hormone. Calcitriol increases intestinal absorption of calcium and phosphorus, and in concert with parathyroid hormone increases bone resorption.

A calcium-binding protein that is 92 AA long, contains 2 EF-hand domains, and is concentrated mainly in GLIAL CELLS. Elevation of S100B levels in brain tissue correlates with a role in neurological disorders.

The sum of the weight of all the atoms in a molecule.

Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.

Transport proteins that carry specific substances in the blood or across cell membranes.

Histochemical localization of immunoreactive substances using labeled antibodies as reagents.

The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.

Common name for the species Gallus gallus, the domestic fowl, in the family Phasianidae, order GALLIFORMES. It is descended from the red jungle fowl of SOUTHEAST ASIA.

A salt used to replenish calcium levels, as an acid-producing diuretic, and as an antidote for magnesium poisoning.

Carbonic acid calcium salt (CaCO3). An odorless, tasteless powder or crystal that occurs in nature. It is used therapeutically as a phosphate buffer in hemodialysis patients and as a calcium supplement.

The rate dynamics in chemical or physical systems.

Established cell cultures that have the potential to propagate indefinitely.

Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.

The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.

The sequential correspondence of nucleotides in one nucleic acid molecule with those of another nucleic acid molecule. Sequence homology is an indication of the genetic relatedness of different organisms and gene function.

Terbium. An element of the rare earth family of metals. It has the atomic symbol Tb, atomic number 65, and atomic weight 158.92.

A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.

One of the minor protein components of skeletal muscle. Its function is to serve as the calcium-binding component in the troponin-tropomyosin B-actin-myosin complex by conferring calcium sensitivity to the cross-linked actin and myosin filaments.

Calcium salts of phosphoric acid. These compounds are frequently used as calcium supplements.

A metallic element that has the atomic symbol Mg, atomic number 12, and atomic weight 24.31. It is important for the activity of many enzymes, especially those involved in OXIDATIVE PHOSPHORYLATION.

A family of immunophilin proteins that bind to the immunosuppressive drugs TACROLIMUS (also known as FK506) and SIROLIMUS. EC 5.2.1.-

A poly(A) binding protein that has a variety of functions such as mRNA stabilization and protection of RNA from nuclease activity. Although poly(A) binding protein I is considered a major cytoplasmic RNA-binding protein it is also found in the CELL NUCLEUS and may be involved in transport of mRNP particles.

Proteins prepared by recombinant DNA technology.

Long-lasting voltage-gated CALCIUM CHANNELS found in both excitable and nonexcitable tissue. They are responsible for normal myocardial and vascular smooth muscle contractility. Five subunits (alpha-1, alpha-2, beta, gamma, and delta) make up the L-type channel. The alpha-1 subunit is the binding site for calcium-based antagonists. Dihydropyridine-based calcium antagonists are used as markers for these binding sites.

Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.

A neuronal calcium-sensor protein that was initially found in the NEURONS of the HIPPOCAMPUS. It interacts with NEURONAL APOPTOSIS-INHIBITORY PROTEIN.

A family of soluble proteins that bind insulin-like growth factors and modulate their biological actions at the cellular level. (Int J Gynaecol Obstet 1992;39(1):3-9)

Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.

Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.

The calcium salt of oxalic acid, occurring in the urine as crystals and in certain calculi.

Chemicals that bind to and remove ions from solutions. Many chelating agents function through the formation of COORDINATION COMPLEXES with METALS.

Ytterbium. An element of the rare earth family of metals. It has the atomic symbol Yb, atomic number 70, and atomic weight 173. Ytterbium has been used in lasers and as a portable x-ray source.

The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH = log 1/2[1/(H+)], where (H+) is the hydrogen ion concentration in gram equivalents per liter of solution. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)

Lanthanum. The prototypical element in the rare earth family of metals. It has the atomic symbol La, atomic number 57, and atomic weight 138.91. Lanthanide ion is used in experimental biology as a calcium antagonist; lanthanum oxide improves the optical properties of glass.

The calcium salt of gluconic acid. The compound has a variety of uses, including its use as a calcium replenisher in hypocalcemic states.

A change from planar to elliptic polarization when an initially plane-polarized light wave traverses an optically active medium. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)

Proteins that bind to RNA molecules. Included here are RIBONUCLEOPROTEINS and other proteins whose function is to bind specifically to RNA.

Positively charged atoms, radicals or groups of atoms with a valence of plus 2, which travel to the cathode or negative pole during electrolysis.

Monomeric subunits of primarily globular ACTIN and found in the cytoplasmic matrix of almost all cells. They are often associated with microtubules and may play a role in cytoskeletal function and/or mediate movement of the cell or the organelles within the cell.

Intracellular proteins that reversibly bind hydrophobic ligands including: saturated and unsaturated FATTY ACIDS; EICOSANOIDS; and RETINOIDS. They are considered a highly conserved and ubiquitously expressed family of proteins that may play a role in the metabolism of LIPIDS.

The level of protein structure in which regular hydrogen-bond interactions within contiguous stretches of polypeptide chain give rise to alpha helices, beta strands (which align to form beta sheets) or other types of coils. This is the first folding level of protein conformation.

Electrophoresis in which a polyacrylamide gel is used as the diffusion medium.

Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING).

Recombinant proteins produced by the GENETIC TRANSLATION of fused genes formed by the combination of NUCLEIC ACID REGULATORY SEQUENCES of one or more genes with the protein coding sequences of one or more genes.

Intracellular fluid from the cytoplasm after removal of ORGANELLES and other insoluble cytoplasmic components.

A process of selective diffusion through a membrane. It is usually used to separate low-molecular-weight solutes which diffuse through the membrane from the colloidal and high-molecular-weight solutes which do not. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)

A class of organic compounds that contains a naphthalene moiety linked to a sulfonic acid salt or ester.

A poly(A) binding protein that is involved in promoting the extension of the poly A tails of MRNA. The protein requires a minimum of ten ADENOSINE nucleotides in order for binding to mRNA. Once bound it works in conjunction with CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR to stimulate the rate of poly A synthesis by POLY A POLYMERASE. Once poly-A tails reach around 250 nucleotides in length poly(A) binding protein II no longer stimulates POLYADENYLATION. Mutations within a GCG repeat region in the gene for poly(A) binding protein II have been shown to cause the disease MUSCULAR DYSTROPHY, OCULOPHARYNGEAL.

The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.

Elements of limited time intervals, contributing to particular results or situations.

Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.

Genetically engineered MUTAGENESIS at a specific site in the DNA molecule that introduces a base substitution, or an insertion or deletion.

An autosomal dominant disorder of CONNECTIVE TISSUE with abnormal features in the heart, the eye, and the skeleton. Cardiovascular manifestations include MITRAL VALVE PROLAPSE, dilation of the AORTA, and aortic dissection. Other features include lens displacement (ectopia lentis), disproportioned long limbs and enlarged DURA MATER (dural ectasia). Marfan syndrome is associated with mutations in the gene encoding fibrillin, a major element of extracellular microfibrils of connective tissue.

A group of elements that include SCANDIUM; YTTRIUM; and the LANTHANOID SERIES ELEMENTS. Historically, the rare earth metals got their name from the fact that they were never found in their pure elemental form, but as an oxide. In addition they were very difficult to purify. They are not truly rare and comprise about 25% of the metals in the earth's crust.

Inorganic compounds that contain calcium as an integral part of the molecule.

CALCIUM CHANNELS that are concentrated in neural tissue. Omega toxins inhibit the actions of these channels by altering their voltage dependence.

Partial proteins formed by partial hydrolysis of complete proteins or generated through PROTEIN ENGINEERING techniques.

The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.

A chelating agent that sequesters a variety of polyvalent cations such as CALCIUM. It is used in pharmaceutical manufacturing and as a food additive.

The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.

The protein constituents of muscle, the major ones being ACTINS and MYOSINS. More than a dozen accessory proteins exist including TROPONIN; TROPOMYOSIN; and DYSTROPHIN.

One of the six homologous soluble proteins that bind insulin-like growth factors (SOMATOMEDINS) and modulate their mitogenic and metabolic actions at the cellular level.

An atom or group of atoms that have a positive or negative electric charge due to a gain (negative charge) or loss (positive charge) of one or more electrons. Atoms with a positive charge are known as CATIONS; those with a negative charge are ANIONS.

Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.

The relationship between the dose of an administered drug and the response of the organism to the drug.

A family of intracellular calcium-sensing proteins found predominately in NEURONS and PHOTORECEPTOR CELLS. They contain EF HAND MOTIFS and undergo conformational changes upon calcium-binding. Neuronal calcium-sensor proteins interact with other regulatory proteins to mediate physiological responses to a change in intracellular calcium concentration.

Periplasmic proteins that scavenge or sense diverse nutrients. In the bacterial environment they usually couple to transporters or chemotaxis receptors on the inner bacterial membrane.

The introduction of a phosphoryl group into a compound through the formation of an ester bond between the compound and a phosphorus moiety.

Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.

Single-stranded complementary DNA synthesized from an RNA template by the action of RNA-dependent DNA polymerase. cDNA (i.e., complementary DNA, not circular DNA, not C-DNA) is used in a variety of molecular cloning experiments as well as serving as a specific hybridization probe.

Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.

Cation-transporting proteins that utilize the energy of ATP hydrolysis for the transport of CALCIUM. They differ from CALCIUM CHANNELS which allow calcium to pass through a membrane without the use of energy.

The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.

A phenothiazine with actions similar to CHLORPROMAZINE. It is used as an antipsychotic and an antiemetic.

A rigorously mathematical analysis of energy relationships (heat, work, temperature, and equilibrium). It describes systems whose states are determined by thermal parameters, such as temperature, in addition to mechanical and electromagnetic parameters. (From Hawley's Condensed Chemical Dictionary, 12th ed)

Commonly observed structural components of proteins formed by simple combinations of adjacent secondary structures. A commonly observed structure may be composed of a CONSERVED SEQUENCE which can be represented by a CONSENSUS SEQUENCE.

A tetrameric calcium release channel in the SARCOPLASMIC RETICULUM membrane of SMOOTH MUSCLE CELLS, acting oppositely to SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES. It is important in skeletal and cardiac excitation-contraction coupling and studied by using RYANODINE. Abnormalities are implicated in CARDIAC ARRHYTHMIAS and MUSCULAR DISEASES.

The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.

A group of enzymes which catalyze the hydrolysis of ATP. The hydrolysis reaction is usually coupled with another function such as transporting Ca(2+) across a membrane. These enzymes may be dependent on Ca(2+), Mg(2+), anions, H+, or DNA.

A photoprotein isolated from the bioluminescent jellyfish Aequorea. It emits visible light by an intramolecular reaction when a trace amount of calcium ion is added. The light-emitting moiety in the bioluminescence reaction is believed to be 2-amino-3-benzyl-5-(p-hydroxyphenyl)pyrazine (AF-350).

Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors.

A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.

An adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.

Found in various tissues, particularly in four blood-clotting proteins including prothrombin, in kidney protein, in bone protein, and in the protein present in various ectopic calcifications.

Agents that emit light after excitation by light. The wave length of the emitted light is usually longer than that of the incident light. Fluorochromes are substances that cause fluorescence in other substances, i.e., dyes used to mark or label other compounds with fluorescent tags.

A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).

The interaction of two or more substrates or ligands with the same binding site. The displacement of one by the other is used in quantitative and selective affinity measurements.

A neuronal calcium sensor protein that is expressed as several isoforms and can interact with ACTIN; TUBULIN; and CLATHRIN.

Agents that increase calcium influx into calcium channels of excitable tissues. This causes vasoconstriction in VASCULAR SMOOTH MUSCLE and/or CARDIAC MUSCLE cells as well as stimulation of insulin release from pancreatic islets. Therefore, tissue-selective calcium agonists have the potential to combat cardiac failure and endocrinological disorders. They have been used primarily in experimental studies in cell and tissue culture.

A 12-KDa tacrolimus binding protein that is found associated with and may modulate the function of calcium release channels. It is a peptidyl-prolyl cis/trans isomerase which is inhibited by both tacrolimus (commonly called FK506) and SIROLIMUS.

A multifunctional protein that is found primarily within membrane-bound organelles. In the ENDOPLASMIC RETICULUM it binds to specific N-linked oligosaccharides found on newly-synthesized proteins and functions as a MOLECULAR CHAPERONE that may play a role in PROTEIN FOLDING or retention and degradation of misfolded proteins. In addition calreticulin is a major storage form for CALCIUM and functions as a calcium-signaling molecule that can regulate intracellular calcium HOMEOSTASIS.

The voltage differences across a membrane. For cellular membranes they are computed by subtracting the voltage measured outside the membrane from the voltage measured inside the membrane. They result from differences of inside versus outside concentration of potassium, sodium, chloride, and other ions across cells' or ORGANELLES membranes. For excitable cells, the resting membrane potentials range between -30 and -100 millivolts. Physical, chemical, or electrical stimuli can make a membrane potential more negative (hyperpolarization), or less negative (depolarization).

The branch of science that deals with the geometric description of crystals and their internal arrangement. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)

A family of secreted multidomain proteins that were originally identified by their association with the latent form of TRANSFORMING GROWTH FACTORS. They interact with a variety of EXTRACELLULAR MATRIX PROTEINS and may play a role in the regulation of TGB-beta bioavailability.

The study of crystal structure using X-RAY DIFFRACTION techniques. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)

The measurement of the quantity of heat involved in various processes, such as chemical reactions, changes of state, and formations of solutions, or in the determination of the heat capacities of substances. The fundamental unit of measurement is the joule or the calorie (4.184 joules). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)

A phylum of the kingdom Metazoa. Mollusca have soft, unsegmented bodies with an anterior head, a dorsal visceral mass, and a ventral foot. Most are encased in a protective calcareous shell. It includes the classes GASTROPODA; BIVALVIA; CEPHALOPODA; Aplacophora; Scaphopoda; Polyplacophora; and Monoplacophora.

Family of calcium- and phospholipid-binding proteins which are structurally related and exhibit immunological cross-reactivity. Each member contains four homologous 70-kDa repeats. The annexins are differentially distributed in vertebrate tissues (and lower eukaryotes) and appear to be involved in MEMBRANE FUSION and SIGNAL TRANSDUCTION.

Proteins found in the nucleus of a cell. Do not confuse with NUCLEOPROTEINS which are proteins conjugated with nucleic acids, that are not necessarily present in the nucleus.

The protein components of a number of complexes, such as enzymes (APOENZYMES), ferritin (APOFERRITINS), or lipoproteins (APOLIPOPROTEINS).

A system of cisternae in the CYTOPLASM of many cells. In places the endoplasmic reticulum is continuous with the plasma membrane (CELL MEMBRANE) or outer membrane of the nuclear envelope. If the outer surfaces of the endoplasmic reticulum membranes are coated with ribosomes, the endoplasmic reticulum is said to be rough-surfaced (ENDOPLASMIC RETICULUM, ROUGH); otherwise it is said to be smooth-surfaced (ENDOPLASMIC RETICULUM, SMOOTH). (King & Stansfield, A Dictionary of Genetics, 4th ed)

One of the six homologous soluble proteins that bind insulin-like growth factors (SOMATOMEDINS) and modulate their mitogenic and metabolic actions at the cellular level.

A bile salt formed in the liver by conjugation of deoxycholate with taurine, usually as the sodium salt. It is used as a cholagogue and choleretic, also industrially as a fat emulsifier.

A superorder of marine CRUSTACEA, free swimming in the larval state, but permanently fixed as adults. There are some 800 described species, grouped in several genera, and comprising of two major orders of barnacles: stalked (Pedunculata) and sessile (Sessilia).

The lipid- and protein-containing, selectively permeable membrane that surrounds the cytoplasm in prokaryotic and eukaryotic cells.

A protein that has been shown to function as a calcium-regulated transcription factor as well as a substrate for depolarization-activated CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASES. This protein functions to integrate both calcium and cAMP signals.

Processes involved in the formation of TERTIARY PROTEIN STRUCTURE.

Short sequences (generally about 10 base pairs) of DNA that are complementary to sequences of messenger RNA and allow reverse transcriptases to start copying the adjacent sequences of mRNA. Primers are used extensively in genetic and molecular biology techniques.

The movement of materials (including biochemical substances and drugs) through a biological system at the cellular level. The transport can be across cell membranes and epithelial layers. It also can occur within intracellular compartments and extracellular compartments.

An ionophorous, polyether antibiotic from Streptomyces chartreusensis. It binds and transports CALCIUM and other divalent cations across membranes and uncouples oxidative phosphorylation while inhibiting ATPase of rat liver mitochondria. The substance is used mostly as a biochemical tool to study the role of divalent cations in various biological systems.

A general transcription factor that plays a major role in the activation of eukaryotic genes transcribed by RNA POLYMERASES. It binds specifically to the TATA BOX promoter element, which lies close to the position of transcription initiation in RNA transcribed by RNA POLYMERASE II. Although considered a principal component of TRANSCRIPTION FACTOR TFIID it also takes part in general transcription factor complexes involved in RNA POLYMERASE I and RNA POLYMERASE III transcription.

Organic esters or salts of sulfonic acid derivatives containing an aliphatic hydrocarbon radical.

The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.

A white crystal or crystalline powder used in BUFFERS; FERTILIZERS; and EXPLOSIVES. It can be used to replenish ELECTROLYTES and restore WATER-ELECTROLYTE BALANCE in treating HYPOKALEMIA.

A major protein fraction of milk obtained from the WHEY.

A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.

Proteins found in any species of bacterium.

One of the six homologous proteins that specifically bind insulin-like growth factors (SOMATOMEDINS) and modulate their mitogenic and metabolic actions. The function of this protein is not completely defined. However, several studies demonstrate that it inhibits IGF binding to cell surface receptors and thereby inhibits IGF-mediated mitogenic and cell metabolic actions. (Proc Soc Exp Biol Med 1993;204(1):4-29)

The part of a cell that contains the CYTOSOL and small structures excluding the CELL NUCLEUS; MITOCHONDRIA; and large VACUOLES. (Glick, Glossary of Biochemistry and Molecular Biology, 1990)

DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. Highly conserved sequences within the promoter include the Pribnow box in bacteria and the TATA BOX in eukaryotes.

A chemical system that functions to control the levels of specific ions in solution. When the level of hydrogen ion in solution is controlled the system is called a pH buffer.

Macromolecular organic compounds that contain carbon, hydrogen, oxygen, nitrogen, and usually, sulfur. These macromolecules (proteins) form an intricate meshwork in which cells are embedded to construct tissues. Variations in the relative types of macromolecules and their organization determine the type of extracellular matrix, each adapted to the functional requirements of the tissue. The two main classes of macromolecules that form the extracellular matrix are: glycosaminoglycans, usually linked to proteins (proteoglycans), and fibrous proteins (e.g., COLLAGEN; ELASTIN; FIBRONECTINS; and LAMININ).

The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.

The excitable plasma membrane of a muscle cell. (Glick, Glossary of Biochemistry and Molecular Biology, 1990)

Compounds with three aromatic rings in linear arrangement with an OXYGEN in the center ring.

A theoretical representative nucleotide or amino acid sequence in which each nucleotide or amino acid is the one which occurs most frequently at that site in the different sequences which occur in nature. The phrase also refers to an actual sequence which approximates the theoretical consensus. A known CONSERVED SEQUENCE set is represented by a consensus sequence. Commonly observed supersecondary protein structures (AMINO ACID MOTIFS) are often formed by conserved sequences.

NMR spectroscopy on small- to medium-size biological macromolecules. This is often used for structural investigation of proteins and nucleic acids, and often involves more than one isotope.

Fibrinogens which have a functional defect as the result of one or more amino acid substitutions in the amino acid sequence of normal fibrinogen. Abnormalities of the fibrinogen molecule may impair any of the major steps involved in the conversion of fibrinogen into stabilized fibrin, such as cleavage of the fibrinopeptides by thrombin, polymerization and cross-linking of fibrin. The resulting dysfibrinogenemias can be clinically silent or can be associated with bleeding, thrombosis or defective wound healing.

Proteins which bind with RETINOL. The retinol-binding protein found in plasma has an alpha-1 mobility on electrophoresis and a molecular weight of about 21 kDa. The retinol-protein complex (MW=80-90 kDa) circulates in plasma in the form of a protein-protein complex with prealbumin. The retinol-binding protein found in tissue has a molecular weight of 14 kDa and carries retinol as a non-covalently-bound ligand.

Microscopy of specimens stained with fluorescent dye (usually fluorescein isothiocyanate) or of naturally fluorescent materials, which emit light when exposed to ultraviolet or blue light. Immunofluorescence microscopy utilizes antibodies that are labeled with fluorescent dye.

A white powder prepared from lime that has many medical and industrial uses. It is in many dental formulations, especially for root canal filling.

A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.

Conversion of an inactive form of an enzyme to one possessing metabolic activity. It includes 1, activation by ions (activators); 2, activation by cofactors (coenzymes); and 3, conversion of an enzyme precursor (proenzyme or zymogen) to an active enzyme.

A subtype of striated muscle, attached by TENDONS to the SKELETON. Skeletal muscles are innervated and their movement can be consciously controlled. They are also called voluntary muscles.

A member of the p300-CBP transcription factor family that was initially identified as a binding partner for CAMP RESPONSE ELEMENT-BINDING PROTEIN. Mutations in CREB-binding protein are associated with RUBINSTEIN-TAYBI SYNDROME.

Filamentous proteins that are the main constituent of the thin filaments of muscle fibers. The filaments (known also as filamentous or F-actin) can be dissociated into their globular subunits; each subunit is composed of a single polypeptide 375 amino acids long. This is known as globular or G-actin. In conjunction with MYOSINS, actin is responsible for the contraction and relaxation of muscle.

A non-metal element that has the atomic symbol P, atomic number 15, and atomic weight 31. It is an essential element that takes part in a broad variety of biochemical reactions.

A polypeptide hormone (84 amino acid residues) secreted by the PARATHYROID GLANDS which performs the essential role of maintaining intracellular CALCIUM levels in the body. Parathyroid hormone increases intracellular calcium by promoting the release of CALCIUM from BONE, increases the intestinal absorption of calcium, increases the renal tubular reabsorption of calcium, and increases the renal excretion of phosphates.

Microscopy using an electron beam, instead of light, to visualize the sample, thereby allowing much greater magnification. The interactions of ELECTRONS with specimens are used to provide information about the fine structure of that specimen. In TRANSMISSION ELECTRON MICROSCOPY the reactions of the electrons that are transmitted through the specimen are imaged. In SCANNING ELECTRON MICROSCOPY an electron beam falls at a non-normal angle on the specimen and the image is derived from the reactions occurring above the plane of the specimen.

Different forms of a protein that may be produced from different GENES, or from the same gene by ALTERNATIVE SPLICING.

A potent vasodilator agent with calcium antagonistic action. It is a useful anti-anginal agent that also lowers blood pressure.

The property of objects that determines the direction of heat flow when they are placed in direct thermal contact. The temperature is the energy of microscopic motions (vibrational and translational) of the particles of atoms.

A calcium salt that is used for a variety of purposes including: building materials, as a desiccant, in dentistry as an impression material, cast, or die, and in medicine for immobilizing casts and as a tablet excipient. It exists in various forms and states of hydration. Plaster of Paris is a mixture of powdered and heat-treated gypsum.

An electrophysiologic technique for studying cells, cell membranes, and occasionally isolated organelles. All patch-clamp methods rely on a very high-resistance seal between a micropipette and a membrane; the seal is usually attained by gentle suction. The four most common variants include on-cell patch, inside-out patch, outside-out patch, and whole-cell clamp. Patch-clamp methods are commonly used to voltage clamp, that is control the voltage across the membrane and measure current flow, but current-clamp methods, in which the current is controlled and the voltage is measured, are also used.

An essential amino acid that is necessary for normal growth in infants and for NITROGEN balance in adults. It is a precursor of INDOLE ALKALOIDS in plants. It is a precursor of SEROTONIN (hence its use as an antidepressant and sleep aid). It can be a precursor to NIACIN, albeit inefficiently, in mammals.

A serine endopeptidase that is formed from TRYPSINOGEN in the pancreas. It is converted into its active form by ENTEROPEPTIDASE in the small intestine. It catalyzes hydrolysis of the carboxyl group of either arginine or lysine. EC 3.4.21.4.

An alpha-globulin found in the plasma of man and other vertebrates. It is apparently synthesized in the liver and carries vitamin D and its metabolites through the circulation and mediates the response of tissue. It is also known as group-specific component (Gc). Gc subtypes are used to determine specific phenotypes and gene frequencies. These data are employed in the classification of population groups, paternity investigations, and in forensic medicine.

A class of proteins that were originally identified by their ability to bind the DNA sequence CCAAT. The typical CCAAT-enhancer binding protein forms dimers and consists of an activation domain, a DNA-binding basic region, and a leucine-rich dimerization domain (LEUCINE ZIPPERS). CCAAT-BINDING FACTOR is structurally distinct type of CCAAT-enhancer binding protein consisting of a trimer of three different subunits.

The concentration of osmotically active particles in solution expressed in terms of osmoles of solute per liter of solution. Osmolality is expressed in terms of osmoles of solute per kilogram of solvent.

Artifactual vesicles formed from the endoplasmic reticulum when cells are disrupted. They are isolated by differential centrifugation and are composed of three structural features: rough vesicles, smooth vesicles, and ribosomes. Numerous enzyme activities are associated with the microsomal fraction. (Glick, Glossary of Biochemistry and Molecular Biology, 1990; from Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed)

The first continuously cultured human malignant CELL LINE, derived from the cervical carcinoma of Henrietta Lacks. These cells are used for VIRUS CULTIVATION and antitumor drug screening assays.

The deductive study of shape, quantity, and dependence. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)

A fluorescent calcium chelating agent which is used to study intracellular calcium in tissues.

A member of the alkali group of metals. It has the atomic symbol Na, atomic number 11, and atomic weight 23.

A RNA-binding protein that binds to polypyriminidine rich regions in the INTRONS of messenger RNAs. Polypyrimidine tract-binding protein may be involved in regulating the ALTERNATIVE SPLICING of mRNAs since its presence on an intronic RNA region that is upstream of an EXON inhibits the splicing of the exon into the final mRNA product.

Measurement of the polarization of fluorescent light from solutions or microscopic specimens. It is used to provide information concerning molecular size, shape, and conformation, molecular anisotropy, electronic energy transfer, molecular interaction, including dye and coenzyme binding, and the antigen-antibody reaction.

A molecule that binds to another molecule, used especially to refer to a small molecule that binds specifically to a larger molecule, e.g., an antigen binding to an antibody, a hormone or neurotransmitter binding to a receptor, or a substrate or allosteric effector binding to an enzyme. Ligands are also molecules that donate or accept a pair of electrons to form a coordinate covalent bond with the central metal atom of a coordination complex. (From Dorland, 27th ed)

A diverse superfamily of proteins that function as translocating proteins. They share the common characteristics of being able to bind ACTINS and hydrolyze MgATP. Myosins generally consist of heavy chains which are involved in locomotion, and light chains which are involved in regulation. Within the structure of myosin heavy chain are three domains: the head, the neck and the tail. The head region of the heavy chain contains the actin binding domain and MgATPase domain which provides energy for locomotion. The neck region is involved in binding the light-chains. The tail region provides the anchoring point that maintains the position of the heavy chain. The superfamily of myosins is organized into structural classes based upon the type and arrangement of the subunits they contain.

The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)

A sesquiterpene lactone found in roots of THAPSIA. It inhibits CA(2+)-TRANSPORTING ATPASE mediated uptake of CALCIUM into SARCOPLASMIC RETICULUM.

One of the six homologous soluble proteins that bind insulin-like growth factors (SOMATOMEDINS) and modulate their mitogenic and metabolic actions at the cellular level.

Endocytosis: EH domains lend a hand. (1/7886)

A number of proteins that have been implicated in endocytosis feature a conserved protein-interaction module known as an EH domain. The three-dimensional structure of an EH domain has recently been solved, and is likely to presage significant advances in understanding molecular mechanisms of endocytosis. (+info)

Binding of the G domains of laminin alpha1 and alpha2 chains and perlecan to heparin, sulfatides, alpha-dystroglycan and several extracellular matrix proteins. (2/7886)

The C-terminal G domain of the mouse laminin alpha2 chain consists of five lamin-type G domain (LG) modules (alpha2LG1 to alpha2LG5) and was obtained as several recombinant fragments, corresponding to either individual modules or the tandem arrays alpha2LG1-3 and alpha2LG4-5. These fragments were compared with similar modules from the laminin alpha1 chain and from the C-terminal region of perlecan (PGV) in several binding studies. Major heparin-binding sites were located on the two tandem fragments and the individual alpha2LG1, alpha2LG3 and alpha2LG5 modules. The binding epitope on alpha2LG5 could be localized to a cluster of lysines by site-directed mutagenesis. In the alpha1 chain, however, strong heparin binding was found on alpha1LG4 and not on alpha1LG5. Binding to sulfatides correlated to heparin binding in most but not all cases. Fragments alpha2LG1-3 and alpha2LG4-5 also bound to fibulin-1, fibulin-2 and nidogen-2 with Kd = 13-150 nM. Both tandem fragments, but not the individual modules, bound strongly to alpha-dystroglycan and this interaction was abolished by EDTA but not by high concentrations of heparin and NaCl. The binding of perlecan fragment PGV to alpha-dystroglycan was even stronger and was also not sensitive to heparin. This demonstrated similar binding repertoires for the LG modules of three basement membrane proteins involved in cell-matrix interactions and supramolecular assembly. (+info)

Identification of a novel family of targets of PYK2 related to Drosophila retinal degeneration B (rdgB) protein. (3/7886)

The protein tyrosine kinase PYK2 has been implicated in signaling pathways activated by G-protein-coupled receptors, intracellular calcium, and stress signals. Here we describe the molecular cloning and characterization of a novel family of PYK2-binding proteins designated Nirs (PYK2 N-terminal domain-interacting receptors). The three Nir proteins (Nir1, Nir2, and Nir3) bind to the amino-terminal domain of PYK2 via a conserved sequence motif located in the carboxy terminus. The primary structures of Nirs reveal six putative transmembrane domains, a region homologous to phosphatidylinositol (PI) transfer protein, and an acidic domain. The Nir proteins are the human homologues of the Drosophila retinal degeneration B protein (rdgB), a protein implicated in the visual transduction pathway in flies. We demonstrate that Nirs are calcium-binding proteins that exhibit PI transfer activity in vivo. Activation of PYK2 by agents that elevate intracellular calcium or by phorbol ester induce tyrosine phosphorylation of Nirs. Moreover, PYK2 and Nirs exhibit similar expression patterns in several regions of the brain and retina. In addition, PYK2-Nir complexes are detected in lysates prepared from cultured cells or from brain tissues. Finally, the Nir1-encoding gene is located at human chromosome 17p13.1, in proximity to a locus responsible for several human retinal diseases. We propose that the Nir and rdgB proteins represent a new family of evolutionarily conserved PYK2-binding proteins that play a role in the control of calcium and phosphoinositide metabolism downstream of G-protein-coupled receptors. (+info)

Phospholamban is present in endothelial cells and modulates endothelium-dependent relaxation. Evidence from phospholamban gene-ablated mice. (4/7886)

Vascular endothelial cells regulate vascular smooth muscle tone through Ca2+-dependent production and release of vasoactive molecules. Phospholamban (PLB) is a 24- to 27-kDa phosphoprotein that modulates activity of the sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA). Expression of PLB is reportedly limited to cardiac, slow-twitch skeletal and smooth muscle in which PLB is an important regulator of [Ca2+]i and contractility in these muscles. In the present study, we report the existence of PLB in the vascular endothelium, a nonmuscle tissue, and provide functional data on PLB regulation of vascular contractility through its actions in the endothelium. Endothelium-dependent relaxation to acetylcholine was attenuated in aorta of PLB-deficient (PLB-KO) mice compared with wild-type (WT) controls. This effect was not due to actions of nitric oxide on the smooth muscle, because sodium nitroprusside-mediated relaxation in either denuded or endothelium-intact aortas was unaffected by PLB ablation. Relative to denuded vessels, relaxation to forskolin was enhanced in WT endothelium-intact aortas. The endothelium-dependent component of this relaxation was attenuated in PLB-KO aortas. To investigate whether these changes were due to PLB, WT mouse aorta endothelial cells were isolated. Both reverse transcriptase-polymerase chain reaction and Western blot analyses revealed the presence of PLB in endothelial cells, which were shown to be >98% pure by diI-acetylated LDL uptake and nuclear counterstaining. These data indicate that PLB is present and modulates vascular function as a result of its actions in endothelial cells. The presence of PLB in endothelial cells opens new fields for investigation of Ca2+ regulatory pathways in nonmuscle cells and for modulation of endothelial-vascular interactions. (+info)

A novel interaction mechanism accounting for different acylphosphatase effects on cardiac and fast twitch skeletal muscle sarcoplasmic reticulum calcium pumps. (5/7886)

In cardiac and skeletal muscle Ca2+ translocation from cytoplasm into sarcoplasmic reticulum (SR) is accomplished by different Ca2+-ATPases whose functioning involves the formation and decomposition of an acylphosphorylated phosphoenzyme intermediate (EP). In this study we found that acylphosphatase, an enzyme well represented in muscular tissues and which actively hydrolyzes EP, had different effects on heart (SERCA2a) and fast twitch skeletal muscle SR Ca2+-ATPase (SERCA1). With physiological acylphosphatase concentrations SERCA2a exhibited a parallel increase in the rates of both ATP hydrolysis and Ca2+ transport; in contrast, SERCA1 appeared to be uncoupled since the stimulation of ATP hydrolysis matched an inhibition of Ca2+ pump. These different effects probably depend on phospholamban, which is associated with SERCA2a but not SERCA1. Consistent with this view, the present study suggests that acylphosphatase-induced stimulation of SERCA2a, in addition to an enhanced EP hydrolysis, may be due to a displacement of phospholamban, thus to a removal of its inhibitory effect. (+info)

Oligosaccharide modification in the early secretory pathway directs the selection of a misfolded glycoprotein for degradation by the proteasome. (6/7886)

The role of conformation-based quality control in the early secretory pathway is to eliminate misfolded polypeptides and unassembled multimeric protein complexes from the endoplasmic reticulum, ensuring the deployment of only functional molecules to distal sites. The intracellular fate of terminally misfolded human alpha1-antitrypsin was examined in hepatoma cells to identify the functional role of asparagine-linked oligosaccharide modification in the selection of glycoproteins for degradation by the cytosolic proteasome. Proteasomal degradation required physical interaction with the molecular chaperone calnexin. Altered sedimentation of intracellular complexes following treatment with the specific proteasome inhibitor lactacystin, and in combination with mannosidase inhibition, revealed that the removal of mannose from attached oligosaccharides abrogates the release of misfolded alpha1-antitrypsin from calnexin prior to proteasomal degradation. Intracellular turnover was arrested with kifunensine, implicating the participation of endoplasmic reticulum mannosidase I in the disposal process. Accelerated degradation occurred in a mannosidase-independent manner and was arrested by lactacystin, in response to the posttranslational inhibition of glucosidase II, demonstrating that the attenuated removal of glucose from attached oligosaccharides functions as the underlying rate-limiting step in the proteasome-mediated pathway. A model is proposed in which the removal of mannose from multiple attached oligosaccharides directs calnexin in the selection of misfolded alpha1-antitrypsin for degradation by the proteasome. (+info)

Complete exon-intron organization of the mouse fibulin-1 gene and its comparison with the human fibulin-1 gene. (7/7886)

Fibulin-1 is a 90 kDa calcium-binding protein present in the extracellular matrix and in the blood. Two major variants, C and D, differ in their C-termini as well as the ability to bind the basement membrane protein nidogen. Here we characterized genomic clones encoding the mouse fibulin-1 gene, which contains 18 exons spanning at least 75 kb of DNA. The two variants are generated by alternative splicing of exons in the 3' end. By searching the database we identified most of the exons encoding the human fibulin-1 gene and showed that its exon-intron organization is similar to that of the mouse gene. (+info)

Function of WW domains as phosphoserine- or phosphothreonine-binding modules. (8/7886)

Protein-interacting modules help determine the specificity of signal transduction events, and protein phosphorylation can modulate the assembly of such modules into specific signaling complexes. Although phosphotyrosine-binding modules have been well-characterized, phosphoserine- or phosphothreonine-binding modules have not been described. WW domains are small protein modules found in various proteins that participate in cell signaling or regulation. WW domains of the essential mitotic prolyl isomerase Pin1 and the ubiquitin ligase Nedd4 bound to phosphoproteins, including physiological substrates of enzymes, in a phosphorylation-dependent manner. The Pin1 WW domain functioned as a phosphoserine- or phosphothreonine-binding module, with properties similar to those of SRC homology 2 domains. Phosphoserine- or phosphothreonine-binding activity was required for Pin1 to interact with its substrates in vitro and to perform its essential function in vivo. (+info)

Calcium-binding proteins are proteins that participate in calcium cell signalling pathways by binding to Ca2+, the calcium ion ... low-affinity calcium-binding protein calsequestrin. Calretinin is another type of Calcium binding protein weighing 29kD. It is ... Calcium-binding proteins have specific domains that bind to calcium and are known to be heterogeneous. One of the functions of ... Calcium-Binding+Proteins at the US National Library of Medicine Medical Subject Headings (MeSH) (Proteins by function, Calcium ...

https://en.wikipedia.org/wiki/Calcium-binding_protein

Calcium binding protein 1 is a protein that in humans is encoded by the CABP1 gene. Calcium-binding protein 1 is a calcium- ... Calcium binding protein 1". McCue HV, Haynes LP, Burgoyne RD (August 2010). "The diversity of calcium sensor proteins in the ... Calcium binding proteins are an important component of calcium mediated cellular signal transduction. This gene encodes a ... protein that belongs to a subfamily of calcium binding proteins which share similarity to calmodulin. The protein encoded by ...

https://en.wikipedia.org/wiki/Calcium-binding_protein_1

... is a protein that in humans is encoded by the SLC25A12 gene. Aralar is an ... The protein encoded by SLC25A12, Aralar1, is a mitochondrial calcium-binding carrier that facilitates the calcium-dependent ... "SLC25A12 - Calcium-binding mitochondrial carrier protein Aralar1 - Homo sapiens (Human) - SLC25A12 gene & protein". www.uniprot ... "SLC25A12 - Calcium-binding mitochondrial carrier protein Aralar1". Cardiac Organellar Protein Atlas Knowledgebase (COPaKB). ...

https://en.wikipedia.org/wiki/Calcium-binding_mitochondrial_carrier_protein_Aralar1

... is a protein that in humans is encoded by the SLC25A24 gene. This gene ... Human Calcium-binding mitochondrial carrier protein SCaMC-1) at the PDBe-KB. This article incorporates text from the United ... "Identification of a novel human subfamily of mitochondrial carriers with calcium-binding domains". The Journal of Biological ... EF-hand-containing proteins, Solute carrier family, All stub articles, Human chromosome 1 gene stubs). ...

https://en.wikipedia.org/wiki/Calcium-binding_mitochondrial_carrier_protein_SCaMC-1

... is a calcium binding protein. Calponin tonically inhibits the ATPase activity of myosin in smooth muscle. ... Phosphorylation of calponin by a protein kinase, which is dependent upon calcium binding to calmodulin, releases the calponin's ... Calmodulin, when activated by calcium may bind weakly to the CH domain and inhibit calponin binding with α-actin. Calponin is ... It is a binding protein and is made up of three domains. These domains in order of appearance are Calponin Homology (CH), ...

https://en.wikipedia.org/wiki/Calponin

S100A7, S100 calcium-binding protein A7. This disambiguation page lists articles associated with the title Psoriasin. If an ...

https://en.wikipedia.org/wiki/Psoriasin

Hippocalcin is a neuronal calcium-sensor protein which has two to three regions that can bind with calcium ions. The X-linked ... Neuronal Apoptosis-Inhibitory Protein Neuronal Calcium-Sensor Proteins Neuropeptides Olfactory Marker Protein S100 Proteins ... These are typically calcium-binding proteins. There are two types of myelin. The first is oligodendrocyte, which can be found ... a neuronal calcium-sensor protein, has been observed to take place in the zinc-binding region along with other specific amino ...

https://en.wikipedia.org/wiki/Nerve_tissue_protein

Celio, Marco R.; Pauls, Thomas; Schwaller, Beat (1996). Guidebook to the calcium-binding proteins. Oxford: Sambrook & Tooze ... and calprotectin is able to bind a total of four calcium ions per dimer or eight calcium ions per tetramer. Calcium binding ... Zinc can bind at two sites within the calprotectin dimer, and this can occur in the absence of calcium. Calcium, however, ... Manganese or iron are bound by the calprotectin dimer at this His6 site. Zinc can be bound to either of the sites that form at ...

https://en.wikipedia.org/wiki/Calprotectin

"Entrez Gene: S100 calcium binding protein A7A". Wolf, R; Voscopoulos, CJ; FitzGerald, PC; Goldsmith, P; Cataisson, C; Gunsior, ... The S100 calcium-binding protein mS100a7a15 is the murine ortholog of human S100A7 (Psoriasin) and human S100A15 (Koebnerisin ... S100 proteins are a diverse calcium-binding family that mediate fundamental cellular and extracellular processes including cell ... motifs corresponding to the for S100 proteins typical conserved C-terminal and a variant N-terminal EF-hand calcium binding ...

https://en.wikipedia.org/wiki/MS100a7a15

S100 calcium binding protein A14 (S100A14) is a protein that in humans is encoded by the S100A14 gene. This gene encodes a ... "Entrez Gene: S100 calcium binding protein A14". Wang HY, Zhang JY, Cui JT, Tan XH, Li WM, Gu J, Lu YY (Jan 2010). "Expression ... rationale for a new nomenclature of the S100 calcium-binding protein family". Genomics. 25 (3): 638-43. doi:10.1016/0888-7543( ... member of the S100 protein family which contains an EF-hand motif and binds calcium. The gene is located in a cluster of S100 ...

https://en.wikipedia.org/wiki/S100A14

S100 calcium-binding protein A15 (S100A15), also known as koebnerisin and S100 calcium-binding protein A7A (S100A7A), is a ... "Entrez Gene: S100 calcium binding protein A7A". Wolf R, Mirmohammadsadegh A, Walz M, Lysa B, Tartler U, Remus R, Hengge U, ... S100 proteins are a diverse calcium-binding family that regulate fundamental cellular and extracellular processes including ... "Entrez Gene: S100a7a S100 calcium binding protein". Briso EM, Guinea-Viniegra J, Bakiri L, Rogon Z, Petzelbauer P, Eils R, Wolf ...

https://en.wikipedia.org/wiki/S100A15

"Entrez Gene: CHP calcium binding protein P22". Inoue H, Nakamura Y, Nagita M, Takai T, Masuda M, Nakamura N, Kanazawa H (Feb ... Calcineurin B homologous protein 1 is a protein encoded in humans by the CHP1 gene (formerly CHP). The protein encoded by this ... Barroso MR, Bernd KK, DeWitt ND, Chang A, Mills K, Sztul ES (Apr 1996). "A novel Ca2+-binding protein, p22, is required for ... 2003). "Calcineurin homologous protein isoform 2 (CHP2), Na+/H+ exchangers-binding protein, is expressed in intestinal ...

https://en.wikipedia.org/wiki/Calcineurin_B_homologous_protein_1

... bind calcium and phospholipids such as lipocortin. Many other proteins bind calcium, although binding calcium may not be ... Many of the proteins that calmodulin binds are unable to bind calcium themselves, and use calmodulin as a calcium sensor and ... bind only to the Ca2+-bound protein, whereas some proteins, such as NaV channels and IQ-motif proteins, also bind to calmodulin ... an abbreviation for calcium-modulated protein) is a multifunctional intermediate calcium-binding messenger protein expressed in ...

https://en.wikipedia.org/wiki/Calmodulin

S100 calcium-binding protein A16 (S100A16) is a protein that in humans is encoded by the S100A16 gene. GRCh38: Ensembl release ... "Entrez Gene: S100A16 S100 calcium binding protein A16". Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and ... 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173-8. Bibcode: ... Marenholz I, Heizmann CW (2004). "S100A16, a ubiquitously expressed EF-hand protein which is up-regulated in tumors". Biochem. ...

https://en.wikipedia.org/wiki/S100A16

S100 calcium-binding protein A2 (S100A2) is a protein that in humans is encoded by the S100A2 gene and it is located on ... "Entrez Gene: S100A2 S100 calcium binding protein A2". Suzuki F, Oridate N, Homma A, Nakamaru Y, Nagahashi T, Yagi K, et al. ( ... Mueller A, Schäfer BW, Ferrari S, Weibel M, Makek M, Höchli M, Heizmann CW (August 2005). "The calcium-binding protein S100A2 ... Groves P, Finn BE, Kuźnicki J, Forsén S (January 1998). "A model for target protein binding to calcium-activated S100 dimers". ...

https://en.wikipedia.org/wiki/S100A2

"Profilaggrin is a major epidermal calcium-binding protein". Molecular and Cellular Biology. 13 (1): 613-25. doi:10.1128/MCB. ... Filaggrin (filament aggregating protein) is a filament-associated protein that binds to keratin fibers in epithelial cells. Ten ... In humans, profilaggrin is encoded by the FLG gene, which is part of the S100 fused-type protein (SFTP) family within the ... Alternatively, these proteins can interact with keratin intermediate filaments. Filaggrin undergoes further processing in the ...

https://en.wikipedia.org/wiki/Filaggrin

... , also known as S100 calcium-binding protein A1 is a protein which in humans is encoded by the S100A1 gene. ... Baudier J, Glasser N, Gerard D (June 1986). "Ions binding to S100 proteins. I. Calcium- and zinc-binding properties of bovine ... Donato R (July 1999). "Functional roles of S100 proteins, calcium-binding proteins of the EF-hand type". Biochimica et ... Garbuglia M, Verzini M, Giambanco I, Spreca A, Donato R (February 1996). "Effects of calcium-binding proteins (S-100a(o), S- ...

https://en.wikipedia.org/wiki/Protein_S100-A1

This protein binds various extracellular ligands and calcium. It may play a role during organ development, in particular, ... a novel extracellular matrix protein with multiple EGF-like repeats and consensus motifs for calcium binding". J. Cell Biol. ... 1999). "Tropoelastin binding to fibulins, nidogen-2 and other extracellular matrix proteins". FEBS Lett. 460 (2): 280-4. doi: ... 2002). "The leucine-rich repeat protein PRELP binds perlecan and collagens and may function as a basement membrane anchor". J. ...

https://en.wikipedia.org/wiki/FBLN2

S100 calcium-binding protein A11 (S100A11) is a protein that in humans is encoded by the S100A11 gene. The protein encoded by ... "Entrez Gene: S100A11 S100 calcium binding protein A11". Kanamori T, Takakura K, Mandai M, Kariya M, Fukuhara K, Sakaguchi M, et ... October 2004). "Increased expression of calcium-binding protein S100 in human uterine smooth muscle tumours". Molecular Human ... "S100A6 and S100A11 are specific targets of the calcium- and zinc-binding S100B protein in vivo". The Journal of Biological ...

https://en.wikipedia.org/wiki/S100A11

"Calcium-binding protein S100A7 and epidermal-type fatty acid-binding protein are associated in the cytosol of human ... This protein differs from the other S100 proteins of known structure in its lack of calcium binding ability in one EF-hand at ... S100 calcium-binding protein A7 (S100A7), also known as psoriasin, is a protein that in humans is encoded by the S100A7 gene. ... S100A7 is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in ...

https://en.wikipedia.org/wiki/S100A7

Calcium-binding protein 39-like is a protein that in humans is encoded by the CAB39L gene. GRCh38: Ensembl release 89: ... "Entrez Gene: CAB39L calcium binding protein 39-like". Human CAB39L genome location and CAB39L gene details page in the UCSC ... "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi: ...

https://en.wikipedia.org/wiki/CAB39L

S100 calcium-binding protein A13 (S100A13) is a protein that in humans is encoded by the S100A13 gene. The protein encoded by ... "Entrez Gene: S100A13 S100 calcium binding protein A13". Mouta Carreira C, LaVallee TM, Tarantini F, Jackson A, Lathrop JT, ... this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized ... rationale for a new nomenclature of the S100 calcium-binding protein family". Genomics. 25 (3): 638-43. doi:10.1016/0888-7543( ...

https://en.wikipedia.org/wiki/S100A13

... purification and characterization of calcium-triggered luciferin-binding protein of Renilla reniformis". Protein Expression and ... Involvement of a calcium-triggered luciferin binding protein". Biochemistry. 13 (6): 1195-200. doi:10.1021/bi00703a602. PMID ... Unlike photoproteins which stably bind coelenterazine and emit light upon addition of calcium, coelenterazine is normally bound ... and is coupled with a closely interacting green fluorescent protein (RrGFP), and a Ca++ activated luciferin binding protein ( ...

https://en.wikipedia.org/wiki/Renilla-luciferin_2-monooxygenase

S100 calcium-binding protein A8 (S100A8) is a protein that in humans is encoded by the S100A8 gene. It is also known as ... The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 ... "Entrez Gene: S100A8 S100 calcium binding protein A8". Ryan FJ, Hope CM, Masavuli MG, Lynn MA, Mekonnen ZA, Yeow AE, et al. ( ... Schäfer T, Sachse GE, Gassen HG (January 1991). "The calcium-binding protein MRP-8 is produced by human pulmonary tumor cells ...

https://en.wikipedia.org/wiki/S100A8

S100 calcium-binding protein A9 (S100A9) also known as migration inhibitory factor-related protein 14 (MRP14) or calgranulin B ... S100A9 is a member of the S100 family of proteins containing 2 EF hand calcium-binding motifs. S100 proteins are localized in ... "Entrez Gene: S100A9 S100 calcium binding protein A9". Vogl T, Tenbrock K, Ludwig S, Leukert N, Ehrhardt C, van Zoelen MA, ... Dorin JR, Emslie E, van Heyningen V (1991). "Related calcium-binding proteins map to the same subregion of chromosome 1q and to ...

https://en.wikipedia.org/wiki/S100A9

... S100 calcium binding protein A3". Schäfer BW, Heizmann CW (1996). "The S100 family of EF-hand calcium-binding proteins: ... S100 calcium-binding protein A3 (S100A3) is a protein that in humans is encoded by the S100A3 gene. The protein encoded by this ... "Purification and cation binding properties of the recombinant human S100 calcium-binding protein A3, an EF-hand motif protein ... Groves P, Finn BE, Kuźnicki J, Forsén S (1998). "A model for target protein binding to calcium-activated S100 dimers". FEBS ...

https://en.wikipedia.org/wiki/S100A3

S100A4 has been shown to interact with S100 calcium binding protein A1. S100A4, a member of the S100 calcium-binding protein ... "Binding of pEL98 protein, an S100-related calcium-binding protein, to nonmuscle tropomyosin". J. Cell Biol. 124 (5): 757-68. ... The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 ... "Entrez Gene: S100A4 S100 calcium binding protein A4". Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, ...

https://en.wikipedia.org/wiki/Protein_S100-A4

S100 calcium-binding protein A6 (S100A6) is a protein that in humans is encoded by the S100A6 gene. The protein encoded by this ... "Entrez Gene: S100A6 S100 calcium binding protein A6". Deloulme JC, Assard N, Mbele GO, Mangin C, Kuwano R, Baudier J (November ... Schäfer BW, Heizmann CW (1996). "The S100 family of EF-hand calcium-binding proteins: functions and pathology". Trends Biochem ... gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the ...

https://en.wikipedia.org/wiki/S100A6

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. ... S100 calcium-binding protein A12 (S100A12) is a protein that in humans is encoded by the S100A12 gene. Human S100A12, also ... "Entrez Gene: S100A12 S100 calcium binding protein A12". Wicki R, Marenholz I, Mischke D, Schäfer BW, Heizmann CW (December 1996 ... rationale for a new nomenclature of the S100 calcium-binding protein family". Genomics. 25 (3): 638-43. doi:10.1016/0888-7543( ...

https://en.wikipedia.org/wiki/S100A12

... proteins. Many of these proteins require calcium for their biological function and a calcium-binding site has been found at the ... Calcium-binding may be crucial for numerous protein-protein interactions. For human coagulation factor IX it has been shown ... are thought to be involved in stabilising the calcium-binding site. As in non-calcium binding EGF-like domains, there are six ... like domain binds calcium. High resolution NMR structure of the calcium form of the NH2-terminal EGF-like domain in coagulation ...

https://en.wikipedia.org/wiki/Calcium-binding_EGF_domain

Jo DG, Jun JI, Chang JW, Hong YM, Song S, Cho DH, Shim SM, Lee HJ, Cho C, Kim DH, Jung YK (2004). "Calcium binding of ARC ... Nucleolar protein 3 is a protein that in humans is encoded by the NOL3 gene. NOL3 has been shown to interact with SFRS9 and ... "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/ ... "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173-8. Bibcode:2005Natur. ...

https://en.wikipedia.org/wiki/NOL3

Binding of the hormone to insulin receptors on cells then activates a cascade of protein kinases that cause the cells to take ... About 99% of a human's body weight is made up of the elements carbon, nitrogen, calcium, sodium, chlorine, potassium, hydrogen ... Metal cofactors are bound tightly to specific sites in proteins; although enzyme cofactors can be modified during catalysis, ... Metal micronutrients are taken up into organisms by specific transporters and bind to storage proteins such as ferritin or ...

https://en.wikipedia.org/wiki/Metabolism

It exists in its own granule after translation, and release of the protein is triggered by Protein Kinase C (PKC). Its C- and N ... Perforin, unlike GNLY, binds preferably to cholesterol rich membranes and permeabilizes the infected cell which allows the ... One mechanism of cell destruction is through initiating calcium increase, which harms the mitochondria and increases the level ... It is expressed in 2 forms: a 15kDa precursor protein, the translation product, and a 9kDa cytotoxic protein, which is formed ...

https://en.wikipedia.org/wiki/GNLY

... independent of the occupational states of its other binding sites. This protein is deactivated by binding ATP, and activated by ... It later becomes incorporated into the CatSper complex, a specialized calcium ion channel that enables spermatozoa motility. ... Heat shock 70kDa protein 1B is a chaperone protein, cooperating with other heat shock proteins and chaperone systems to ... Mohanan V, Grimes CL (July 2014). "The molecular chaperone HSP70 binds to and stabilizes NOD2, an important protein involved in ...

https://en.wikipedia.org/wiki/HSPA1B

... the gene also contains sequence encoding calcium-binding motifs found in all cadherins. The role of the hybrid extracellular ... Mucin and cadherin-like protein is a protein that in humans is encoded by the MUPCDH gene. This gene is a novel mucin-like gene ... 2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and ... While encoding nonpolymorphic tandem repeats rich in proline, serine and threonine similar to mucin proteins, ...

https://en.wikipedia.org/wiki/MUPCDH

WW domain binding protein 1-like), CACNA1C (Calcium channel, voltage-dependent, L type, alpha 1C subunit), DPYD ( ... This binding in turn results in an inhibition of translation of the target protein or degradation of the target messenger RNA. ... Zinc finger E-box-binding homeobox 2) and PRKD3 (Serine/threonine-protein kinase D3). Neault et al. recently identified miR-137 ... By suppressing Jarid1b protein level, miR-137 is believed to play a role in modulating the differentiated state of mouse ESCs. ...

https://en.wikipedia.org/wiki/MiR-137

... the protein encoded by this locus does not bind to feline leukemia virus subgroup C envelope protein. The encoded protein may ... The encoded transmembrane protein is a calcium transporter. Unlike the related protein feline leukemia virus subgroup C ... Feline leukemia virus subgroup C cellular receptor family, member 2 is a protein that in humans is encoded by the FLVCR2 gene. ... Duffy SP, Shing J, Saraon P, Berger LC, Eiden MV, Wilde A, Tailor CS (Nov 2010). "The Fowler syndrome-associated protein FLVCR2 ...

https://en.wikipedia.org/wiki/FLVCR2

There is also a group of tracers that consist of protein products that can be taken up by the cell and transported across the ... WGA enters the cell by binding to oligosaccharides, and is then taken up via endocytosis via a caveolae-dependent pathway. ... Mn2+ enters through voltage dependent calcium channels, is taken into intracellular organelles and is transported by the ... virus or protein can be locally injected, after which it is allowed to be transported anterogradely. Viral tracers can cross ...

https://en.wikipedia.org/wiki/Anterograde_tracing

The movement of 10-12 of these protein-bound positive charges triggers a conformational change that opens the channel. The ... Jiang Y, Lee A, Chen J, Cadene M, Chait BT, MacKinnon R (May 2002). "Crystal structure and mechanism of a calcium-gated ... Phylogenetic studies of proteins expressed in bacteria revealed the existence of a superfamily of voltage-gated sodium channels ... Voltage-gated ion channels are a class of transmembrane proteins that form ion channels that are activated by changes in the ...

https://en.wikipedia.org/wiki/Voltage-gated_ion_channel

... is variously reported to have no significant plasma protein binding or to have 50% plasma protein binding. Pemoline is ... pemoline calcium, pemoline chromium, and chelates of the above which are identical in weight to the salt mentioned. Pemoline ...

https://en.wikipedia.org/wiki/Pemoline

Dairy products contain nutrients such as calcium; phosphorus; riboflavin; protein; and vitamins A, D and B-12. Protein, a good ... The researchers reached the conclusion that for a community of people, food choice bound by family and household socioeconomic ... Comparatively, only 29.8% of those polled lacked access to adequate protein. The lack of access to fruits and vegetables often ...

https://en.wikipedia.org/wiki/Food_desert

... this membrane protein can also relay extracellular ouabain-binding signalling into the cell through regulation of protein ... This increased presence of calcium is what allows for the force of contraction to be increased. In the case of patients where ... Protein-protein interactions play a very important role in Na⁺-K⁺ pump-mediated signal transduction. For example, the Na⁺-K⁺ ... thus after binding ATP, binds 3 intracellular Na⁺ ions. ATP is hydrolyzed, leading to phosphorylation of the pump at a highly ...

https://en.wikipedia.org/wiki/Sodium–potassium_pump

... by G protein-coupled receptors that can activate or inhibit the NALCN channels depending on the neurotransmitter that binds the ... Calcium-sensitive dyes have shown that internal concentrations of calcium increase during bursts. The activation of different ... Other research has also suggested that calcium flow through N-type calcium channels is essential for normal breathing, and is ... voltage gated calcium channels become activated and calcium is able to flow into the cell which usually leads to the release of ...

https://en.wikipedia.org/wiki/Pre-Bötzinger_complex

In its structural role, zinc coordinates with certain protein domains, facilitating protein folding and producing structures ... Although whole grains and cereals are high in zinc, they also contain chelating phytates which bind zinc and reduce its ... "Effect of mercury vapour exposure on urinary excretion of calcium, zinc and copper: relationship to alterations in functional ... In 2002 the zinc transporter protein ZIP4 was first identified as the mechanism for absorption of zinc in the gut across the ...

https://en.wikipedia.org/wiki/Zinc_deficiency

Some of the most common assays are: ELISAs Protein and cell growth assays Protein:protein interactions Reporter assays Nucleic ... For example, a technique known as calcium imaging measures the fluorescence intensity of calcium-sensitive dyes to assess ... since they allow to detect if a small fluorescent molecule binds (or not) to a larger, non-fluorescent molecule: binding ... For example, large molecules (e.g. proteins) in solution, which rotate relatively slowly because of their size, will emit ...

https://en.wikipedia.org/wiki/Plate_reader

CACNA1E+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH) R-Type+Calcium+Channel at the US ... "A specific tryptophan in the I-II linker is a key determinant of beta-subunit binding and modulation in Ca(V)2.3 calcium ... The R-type calcium channel is a type of voltage-dependent calcium channel. Like the others of this class, the α1 subunit forms ... "Entrez Gene: CACNA1E calcium channel, voltage-dependent, R type, alpha 1E subunit". Soong TW, Stea A, Hodson CD, Dubel SJ, ...

https://en.wikipedia.org/wiki/R-type_calcium_channel

Upon binding to the fungal cell membrane and forming pores, membrane permeability and transport in fungus are altered. As a ... They work by blocking the ability of the fungus to produce proteins in a highly specific way. Hence, disrupting the action of ... Salts of undecylenic acid such as zinc undecenoate and calcium undecenoate are commonly formulated into antifungal creams, ... Finally, it disrupts the synthesis of DNA, RNA and proteins in fungal cells and leads to cell death. Ciclopirox may also exert ...

https://en.wikipedia.org/wiki/Topical_antifungal_drugs

The influx of calcium begins a cascade of events within the cell. Calcium first binds to calmodulin to form CaM. CaM will then ... The surface of the cilia is covered with olfactory receptors, a type of G protein-coupled receptor. Each olfactory receptor ... An odorant will dissolve into the mucus of the olfactory epithelium and then bind to an OR. ORs can bind to a variety of odor ... bind to the CNG channel and close it, stopping the sodium and calcium influx. CaMKII will be activated by the presence of CaM, ...

https://en.wikipedia.org/wiki/Olfactory_receptor_neuron

The protein has N- and C- terminal carbohydrate-binding domains connected by a link peptide. Multiple alternatively spliced ... "Galectin-9 induces apoptosis through the calcium-calpain-caspase-1 pathway". Journal of Immunology. 170 (7): 3631-6. doi: ... However, it can also interact with other proteins (CLEC7A, CD137, CD40). For example, an interaction with CD40 on T-cells ... "Entrez Gene: LGALS9 lectin, galactoside-binding, soluble, 9 (galectin 9)". Daley D, Mani VR, Mohan N, Akkad N, Ochi A, Heindel ...

https://en.wikipedia.org/wiki/Galectin-9

It is classified as a metal-binding protein which is located within the mitochondria. After the protein is taken up by the ... MacKenzie EL, Tsuji Y (2008). "Elevated intracellular calcium increases ferritin H expression through an NFAT-independent post- ... 2005). "Unique iron binding and oxidation properties of human mitochondrial ferritin: a comparative analysis with Human H-chain ... Hasan MR, Tosha T, Theil EC (2008). "Ferritin contains less iron (59Fe) in cells when the protein pores are unfolded by ...

https://en.wikipedia.org/wiki/Mitochondrial_ferritin

Greater than 99% of circulating thyroid hormones are bound to plasma proteins including thyroxine-binding globulin, ... Soy, walnuts, fiber, calcium supplements, and iron supplements can also adversely affect absorption. A study found that cow's ... T4 and T3 bind to thyroid receptor proteins in the cell nucleus and cause metabolic effects through the control of DNA ... Sevelamer with calcium carbonate may decrease the bioavailability of levothyroxine. Grapefruit juice may delay the absorption ...

https://en.wikipedia.org/wiki/Levothyroxine

... binds to cholecystokinin B receptors to stimulate the release of histamines in enterochromaffin-like cells, and it ... hypercalcemia (via calcium-sensing receptors) Gastrin release is inhibited by: the presence of acid (primarily the secreted HCl ... Factors influencing secretion of gastrin can be divided into 2 categories: Stimulatory factors: dietary protein and amino acids ... This is done both directly on the parietal cell[failed verification] and indirectly via binding onto CCK2/gastrin receptors on ...

https://en.wikipedia.org/wiki/Gastrin

Binding of ApoB requires repeats 2-7 while binding ApoE requires only repeat 5 (thought to be the ancestral repeat). Next to ... This protein belongs to the LDLR family and is made up of a number of functionally distinct domains, including 3 EGF-like ... Calcium cages, acid baths and recycling receptors". Nature. 388 (6643): 629-30. Bibcode:1997Natur.388..629B. doi:10.1038/41672 ... Class 3 mutations stop the binding of LDL to the receptor. e.g. repeat 6 of the ligand binding domain (N-terminal, ...

https://en.wikipedia.org/wiki/LDL_receptor

... σ1 receptors and G-proteins have been suggested such as σ1 receptor antagonists showing GTP-sensitive high-affinity binding; ... that modulates calcium signaling through the IP3 receptor. In humans, the σ1 receptor is encoded by the SIGMAR1 gene. The σ1 ... The wide scope and effect of ligand binding on σ1 receptors has led some to believe that σ1 receptors are intracellular signal ... Much is known about the binding affinity of hundreds of synthetic compounds to the σ1 receptor. An endogenous ligand for the σ1 ...

https://en.wikipedia.org/wiki/Sigma-1_receptor

NADK is also reportedly stimulated by calcium/calmodulin binding in certain cell types, such as neutrophils. NAD kinases in ... "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957-68. doi:10.1016/j.cell ... plants and sea urchin eggs have also been found to bind calmodulin. Due to the essential role of NADPH in lipid and DNA ...

https://en.wikipedia.org/wiki/NAD _kinase

Calcium usually binds with other proteins and molecules in order to perform other functions in the body. The calcium bound ... The oxygen binds to the iron in the heme via affinity-based binding or liganding and dissociates from the protein once it has ... Calcium also plays a part in bone structure as the rigidity of vertebrae bone matrices are akin to the nature of the calcium ... Both proteins are tetramer complexes with iron protein complexes called hemes built into each subunit of the tetramer. ...

https://en.wikipedia.org/wiki/Biometal_(biology)

Protein Wnt-3a is a protein that in humans is encoded by the WNT3A gene. The WNT gene family consists of structurally related ... Hino S, Michiue T, Asashima M, Kikuchi A (April 2003). "Casein kinase I epsilon enhances the binding of Dvl-1 to Frat-1 and is ... Thrasivoulou C, Millar M, Ahmed A (December 2013). "Activation of intracellular calcium by multiple Wnt ligands and ... These proteins have are critical in tissue homeostasis, embryonic development, and disease. WNT3A is highly related to the WNT3 ...

https://en.wikipedia.org/wiki/WNT3A

After oxycodone binds to the MOR, a G protein-complex is released, which inhibits the release of neurotransmitters by the cell ... by decreasing the amount of cAMP produced, closing calcium channels, and opening potassium channels. Opioids like oxycodone are ...

https://en.wikipedia.org/wiki/Oxycodone

Calcium/calmodulin-dependent protein kinase type II beta chain is an enzyme that in humans is encoded by the CAMK2B gene. The ... Identification of a regulatory autophosphorylation site adjacent to the inhibitory and calmodulin-binding domains". J. Biol. ... "Entrez Gene: CAMK2B calcium/calmodulin-dependent protein kinase (CaM kinase) II beta". Walikonis RS, Oguni A, Khorosheva EM, ... Sequence analyses of human brain calcium/calmodulin-dependent protein kinase II". Mol. Biol. Rep. 28 (1): 35-41. doi:10.1023/A: ...

https://en.wikipedia.org/wiki/CAMK2B

"Release of fatty acid-binding protein from isolated rat heart subjected to ischemia and reperfusion or to the calcium paradox ... "Revision of the amino acid sequence of human heart fatty acid-binding protein". Cellular Fatty Acid-binding Proteins. Molecular ... Heart-type fatty acid binding protein (hFABP) also known as mammary-derived growth inhibitor is a protein that in humans is ... Heart-type Fatty Acid-Binding Protein (H-FABP) is a small cytoplasmic protein (15 kDa) released from cardiac myocytes following ...

https://en.wikipedia.org/wiki/Heart-type_fatty_acid_binding_protein

protein coding gene. Chr3:93427795-93433595 (+). 129S1/SvImJ MGP_129S1SvImJ_G0027536. protein coding gene. Chr3:94023012- ... protein coding gene. Chr3:87692305-87697408 (+). CAST/EiJ MGP_CASTEiJ_G0026696. protein coding gene. Chr3:92867814-92874659 (+) ... protein coding gene. Chr3:93417338-93424182 (+). C57BL/6NJ MGP_C57BL6NJ_G0027953. protein coding gene. Chr3:97588737-97594558 ... protein coding gene. Chr3:95274212-95281070 (+). NOD/ShiLtJ MGP_NODShiLtJ_G0027356. protein coding gene. Chr3:107232714- ...

http://www.informatics.jax.org/marker/MGI:1338798

Guanine nucleotide binding proteins may modulate gating of calcium channels in vascular smooth muscle. I. Studies with fluoride ... Guanine nucleotide binding proteins may modulate gating of calcium channels in vascular smooth muscle. I. Studies with fluoride ... Guanine nucleotide binding proteins may modulate gating of calcium channels in vascular smooth muscle. I. Studies with fluoride ... Guanine nucleotide binding proteins may modulate gating of calcium channels in vascular smooth muscle. I. Studies with fluoride ...

https://jpet.aspetjournals.org/content/250/1/343

... with a focus on calcium-binding proteins. Neuronal calretinin (CR) immunoreactivity was sparse in Guddens tegmental nuclei and ... these cells did not co-localize with the immunofluorescence of any of the three tested proteins. These findings highlight ... these cells did not co-localize with the immunofluorescence of any of the three tested proteins. These findings highlight ... with a focus on calcium-binding proteins. Neuronal calretinin immunoreactivity was sparse in Guddens tegmental nuclei and ...

https://www.frontiersin.org/articles/10.3389/fnana.2015.00103/full

S100 proteins belong to a family of EF-hand calcium binding proteins that exist mostly as dimers of the 20 currently identified ... S100 calcium binding protein B, Recombinant Protein ... Protein Reagents & Gene Tools*Protein & DNA Accompanying ...

https://www.neuromics.com/PR27082

Boster Bio Anti-Calcium-binding protein 5 CABP5 Antibody catalog # A13209. Tested in WB applications. This antibody reacts with ... calcium binding protein 5; calcium-binding protein 3; calcium-binding protein 5 CABP5 CABP3 calcium binding protein 5 calcium- ... Anti-Calcium-binding protein 5 CABP5 Antibody. CABP5 antibody. Boster Bio Anti-Calcium-binding protein 5 CABP5 Antibody catalog ... binding protein 5,calcium-binding protein 3. *If product is indicated to react with multiple species, protein info is based on ...

https://www.bosterbio.com/anti-calcium-binding-protein-5-cabp5-antibody-a13209-boster.html

Human S100Z Protein is a recombinant Human protein produced in E. coli using Prokaryotic expression. ... S100-Z, S100-Z protein, Protein S100-Z, Human S100-Z Protein, Human S100-Z, Human protein S100-Z ... Human S100Z Protein is a recombinant Human protein produced in E. coli using Prokaryotic expression. Target. S100 Calcium ... Human S100 Calcium Binding Protein Z (S100Z) Protein. Human S100 Calcium Binding Protein Z (S100Z) Protein. ...

https://www.abbexa.com/human-s100z-protein-recombinant

Selective localization of calcium-binding protein in human brainstem, cerebellum and spinal cord. *N. Fournet, L. Garcia-Segura ... Calcium-binding proteins in primate cerebellum. *M. Fortin, R. Marchand, A. Parent ... A Novel Marker for Purkinje Cells, Ribosomal Protein MPS1/S27: Expression of MPS1 in Human Cerebellum.. *J. A. Fernandez-Pol ... and the protein levels of tryptophan hydroxylase 2, the rate-limiting enzyme for serotonin synthesis in the cerebellum, and ...

https://www.semanticscholar.org/paper/Calbindin-D28k-is-a-more-reliable-marker-of-human-A-Whitney-Kemper/a3a922caf14e06fff25aa27c8f77897470507ccc

Polyclonal Antibody to S100 Calcium Binding Protein A11 (S100A11). PAA568Po01 * $37800 $378.00 Unit price/ per ...

https://danabiosci.com/products/polyclonal-antibody-to-s100-calcium-binding-protein-a11-s100a11-paa568po01

Mouse S100B(S100 Calcium Binding Protein B) ELISA Kit. Mouse S100B(S100 Calcium Binding Protein B) ELISA Kit. Order Now: [email ... Human IGFBP5(Insulin Like Growth Factor Binding Protein 5) ELISA Kit. * Human IGFBP7(Insulin Like Growth Factor Binding Protein ... Human IGFBP5(Insulin Like Growth Factor Binding Protein 5) ELISA Kit. *Human IGFBP7(Insulin Like Growth Factor Binding Protein ... Description: A sandwich quantitative ELISA assay kit for detection of Human S100 Calcium Binding Protein B (S100B) in samples ...

https://elisareagents.com/mouse-s100bs100-calcium-binding-protein-b-elisa-kit/

Order Human S100 Calcium Binding Protein A6 S100A6 ELISA kit 01010700716 at Gentaur S100 Calcium Binding Protein A6 (S100A6) ... Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal ...

http://kamiyabio.com/shop-catalog/3332-kamiya/3922-s100-calcium-binding-protein-a6-s100a6-elisa-kit

Hippocalcin (HPCA) is a calcium-binding proteins that is limited to nervous. * Post author By braintumorcancer ... Hippocalcin (HPCA) is a calcium-binding proteins that is limited to nervous tissues and plays a part in neuronal activity. is ... As shown in Physique?1B mRNA expression of and the protein level of HPCA were markedly increased under differentiation ... In addition a number of protein tyrosine phosphatases negatively regulate STAT3 signaling through direct dephosphorylation of p ...

http://www.brain-tumor-cancer-information.com/2017/05/29/hippocalcin-hpca-is-a-calcium-binding-proteins-that-is-limited-to-nervous/

Massive translocation of the visual G-protein transducin, Gt, between subcellular compartments contributes to long term ... Photoisomerization of rhodopsin activates a heterotrimeric G-protein cascade leading to closure of cGMP-gated channels and ... CETN3 protein, human * CETN4 protein, mouse * Calcium-Binding Proteins * Cetn2 protein, mouse ... Binding of Cen2 and Cen4 to Gbetagamma of non-visual G-proteins may additionally regulate G-proteins involved in centrosome and ...

https://pubmed.ncbi.nlm.nih.gov/15347651/

162 Methods In Molecular Biology Volume 172 Calcium-Binding Protein Protocols Volume I. Δημοσιεύτηκε από billpits , 16 Mar 2013 ... Methods In Molecular Biology Volume 172 Calcium-Binding Protein Protocols Volume I. Reviews and Case Studies. by Hans J. Vogel ... Methods In Molecular Biology Volume 173 Calcium-Binding Protein Protocols Volume II »» ... Methods In Molecular Biology Volume 172 Calcium-Binding Protein Protocols Volume I ...

http://billpits.wikidot.com/e-books:162/date/2014.10

... a 14 kDa neutrophil calcium-binding protein belonging to the S-100 protein family of calcium-binding proteins. These results ... Elevated expression of the neutrophil calcium-binding protein, MRP-14, in metastasis-enhancing neutrophils Academic Article ... Because it was most abundant and displayed the greatest differences between PMN subtypes, the M(r) ≃ 14.1 kDa protein was ... We hypothesized that differential protein expression was responsible for functional differences between the neutrophil subtypes ...

http://dgivan.dental.uab.edu/display/pub2086551

The SMOC1 gene provides instructions for making a protein called secreted modular calcium-binding protein 1 (SMOC-1). Learn ... The SMOC1 gene provides instructions for making a protein called secreted modular calcium-binding protein 1 (SMOC-1). This ... The heparin-binding activity of secreted modular calcium-binding protein 1 (SMOC-1) modulates its cell adhesion properties. ... Mutations in the SPARC-related modular calcium-binding protein 1 gene, SMOC1, cause waardenburg anophthalmia syndrome. Am J Hum ...

https://medlineplus.gov/genetics/gene/smoc1/

Production of Calcium-Binding Proteins in Crassostrea virginica in Response to Increased Environmental CO2 Concentration.PDF ... However, elevated pCO2 concentrations enhanced the expression of these calcium-binding protein genes at the protein level. The ... Production of Calcium-Binding Proteins in Crassostrea virginica in Response to Increased Environmental CO2 Concentration ... Here we show the responses of four calcium-binding protein genes, caltractin (cetn), calmodulin (calm), calreticulin (calr), ...

https://frontiersin.figshare.com/articles/figure/Image_5_Production_of_Calcium-Binding_Proteins_in_Crassostrea_virginica_in_Response_to_Increased_Environmental_CO2_Concentration_PDF/6487697/1

Calcium Absorption, Calcium-Binding Protein, and Egg Shell Quality in Laying Hens Fed Hydroxylated Vitamin D Derivatives ... Calcium-binding protein and calcium absorption in the laying quail (Coturnix coturnix japonica). ... Egg shell quality, medullary bone ash, intestinal calcium and phosphorus absorption, and calcium-binding protein in phosphorus- ... Intestinal and uterine calcium binding protein (CaBP) was measured in hens during egg shell calcification, or uterine ...

https://volcaniarchive.agri.gov.il/skn/en/c6/e28417/Scientific_Publication/Intestinal_and_uterine_calcium_binding_protein_in_

The flagellar calcium-binding protein (FCaBP) of Trypanosoma cruzi is localized to the flagellar membrane in all life cycle ... N2 - The flagellar calcium-binding protein (FCaBP) of Trypanosoma cruzi is localized to the flagellar membrane in all life ... AB - The flagellar calcium-binding protein (FCaBP) of Trypanosoma cruzi is localized to the flagellar membrane in all life ... abstract = "The flagellar calcium-binding protein (FCaBP) of Trypanosoma cruzi is localized to the flagellar membrane in all ...

https://www.scholars.northwestern.edu/en/publications/molecular-determinants-of-ciliary-membrane-localization-of-trypan

Calcium-Dependent Membrane-Binding and Localizatio..., 2016. Download whole document (PDF) (18.62 MB) ...

https://scholarly.cmich.edu/?a=d&d=CMUGR2016-62.1.32

Dive into the research topics of Contribution of amygdala neurons containing peptides and calcium-binding proteins to fear- ... Contribution of amygdala neurons containing peptides and calcium-binding proteins to fear-potentiated startle and exploration- ... Contribution of amygdala neurons containing peptides and calcium-binding proteins to fear-potentiated startle and exploration- ... Contribution of amygdala neurons containing peptides and calcium-binding proteins to fear-potentiated startle and exploration- ...

https://creighton.pure.elsevier.com/en/publications/contribution-of-amygdala-neurons-containing-peptides-and-calcium-

Here we focused on two homologous calcium binding proteins, calmodulin and human centrin 2, involved in different cellular ... functions via protein-protein interactions, and known to undergo important conformational changes upon ligand binding. In order ... NMR structures of protein-protein complexes nowadays available could efficiently be exploited for further structure-based drug ... a mimicking alpha-helical molecule known to inhibit protein-protein interactions of calmodulin) into X-ray and NMR ensembles of ...

https://bmcstructbiol.biomedcentral.com/articles/10.1186/1472-6807-11-24

Calcium binding to proteins and other large biological anion centers. Academic Press. 1982. II:1. ... Serum Ionized Calcium. Ionized calcium is the definitive method for diagnosing hypocalcemia. A serum calcium level less than ... Binding of calcium to serum albumin. I. Stoichiometry and intrinsic association constant at physiological pH, ionic strength, ... calcium. To correct for hypoalbuminemia, add 0.8 mg/dL to the total serum calcium for each 1.0 g/dL decrease in albumin below ...

https://www.medscape.com/answers/241893-20166/are-serum-magnesium-levels-measured-in-the-evaluation-for-hypocalcemia

The Gla residues appear to confer calcium binding properties to these proteins.43 In addition there are data from both humans ... Several of these proteins have calcium and apatite binding properties and are concentrated in areas of vascular calcification, ... "calcium score". Within the coronary circulation, the calcium score correlates closely with plaque apatite content. The absence ... 1999) Coronary calcium does not accurately predict near-term future coronary events in high-risk adults. Circulation 99:2633- ...

https://heart.bmj.com/content/85/1/13

Special Issue in Biomolecules: Calcium Binding Proteins: Structure, Properties, Functions. Special Issue in Biomolecules: ... protein folding; protein misfolding; partially folded proteins; protein aggregation; protein structure; protein function; ... protein stability; protein biophysics; protein bioinformatics; conformational diseases; protein-ligand interactions; protein- ... Interests: protein evolution; protein dynamics; protein folding; computational biology; theoretical ecology; chromatin ...

https://www.mdpi.com/journal/biomolecules/editors

1 caveolae protein 22kDa cytochrome P450 relatives one subfamily A polypeptide two insulinlike expansion aspect binding protein ... Hatase placental calcium binding and coiledcoil domain 1 caveolin ... Hatase placental calcium binding and coiledcoil domain 1 caveolin 1 caveolae protein 22kDa cytochrome P450 relatives one ... Uncategorized , Hatase placental calcium binding and coiledcoil domain 1 caveolin 1 caveolae protein 22kDa cytochrome P450 ...

https://www.ck2inhibitor.com/2019/11/29/6470/

Carbon Regulatory Pii-Like Protein Sbtb From Cyanobium Sp. 7001 Bound to Atp and Calcium ... 7001 Bound to Atp and Calcium, PDB code: 6mm2: Chlorine binding site 1 out of 1 in 6mm2. Go back to Chlorine Binding Sites List ... 7001 Bound to Atp and Calcium. Protein crystallography data. The structure of Carbon Regulatory Pii-Like Protein Sbtb From ... The structure of Carbon Regulatory Pii-Like Protein Sbtb From Cyanobium Sp. 7001 Bound to Atp and Calcium also contains other ...

http://chlorine.atomistry.com/pdb6mm2.html

Dive into the research topics of Sequence of rat intestinal vitamin D-dependent calcium-binding protein derived from a cDNA ... Sequence of rat intestinal vitamin D-dependent calcium-binding protein derived from a cDNA clone. Evolutionary implications. / ... Sequence of rat intestinal vitamin D-dependent calcium-binding protein derived from a cDNA clone. Evolutionary implications. In ... Sequence of rat intestinal vitamin D-dependent calcium-binding protein derived from a cDNA clone. Evolutionary implications. ...

https://nyuscholars.nyu.edu/en/publications/sequence-of-rat-intestinal-vitamin-d-dependent-calcium-binding-pr

Name: N-terminal EF-hand calcium binding protein 1. Synonyms: STIP-1, NECAB1, 1700003H21Rik, Efcbp1 ... Name: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide. Synonyms: 14-3-3 beta, ... Name: transformation/transcription domain-associated protein. Synonyms: transactivation/transformation-domain associated ... Synonyms: Ppiase-X, NG7, DIR1, WISp39, WAF-1/CIP1 stabilizing protein 39 ...

https://www.mmrrc.org/catalog/sds.php?mmrrc_id=41996

Identification of a putative calcium-binding protein as a dioxin-responsive gene in zebrafish and rainbow trout. ... Identification of a putative calcium-binding protein as a dioxin-responsive gene in zebrafish and rainbow trout.. Title. ... Amino Acid Sequence, Animals, Base Sequence, Calcium-Binding Proteins, Cells, Cultured, Environmental Pollutants, Gene ... However, demonstration that the encoded S100A4 proteins actually bind calcium and play a role in dioxin toxicity will require ...

https://appliedecon.oregonstate.edu/biblio/identification-putative-calcium-binding-protein-dioxin-responsive-gene-zebrafish-and-rainbow

Calcium binding to proteins and other large biological anion centers. Academic Press. 1982. II:1. ... Binding of calcium to serum albumin. I. Stoichiometry and intrinsic association constant at physiological pH, ionic strength, ... Depending on the calcium level, a graded response will occur: twitching first at the angle of the mouth, then by the nose, the ... Ionized Calcium in the ICU: Should It Be Measured and Corrected?. Chest. 2016 Mar. 149 (3):846-55. [QxMD MEDLINE Link]. ...

https://emedicine.medscape.com/article/241893-clinical

Here we show the responses of four calcium-binding protein genes, caltractin (cetn), calmodulin (calm), calreticulin (calr), and calnexin (canx), to CO 2 -derived OA using a Crassostrea virginica mantle cell (CvMC) culture model and a larval C. virginica model. (figshare.com)
Here we focused on two homologous calcium binding proteins, calmodulin and human centrin 2, involved in different cellular functions via protein-protein interactions, and known to undergo important conformational changes upon ligand binding. (biomedcentral.com)
In order to find suitable protein conformations of calmodulin and centrin for further structure-based drug design/virtual screening, we performed in silico structural/energetic analysis and molecular docking of terphenyl (a mimicking alpha-helical molecule known to inhibit protein-protein interactions of calmodulin) into X-ray and NMR ensembles of calmodulin and centrin. (biomedcentral.com)
Our results show that docking on NMR structures of calmodulin and centrin can be very helpful to take into account conformational changes occurring at protein-protein interfaces. (biomedcentral.com)
Calmodulin (CaM) is a calcium binding protein that plays numerous roles in Ca-dependent cellular processes, including uptake and release of neurotransmitters in neurons. (rcsb.org)
This report describes Ca2+-dependent binding of 125I-labeled calmodulin (125I-CaM) to erythrocyte membranes and identification of two new CaM-binding proteins. (jhu.edu)
Insights into modulation of calcium signaling by magnesium in calmodulin, troponin C and related EF-hand proteins. (bvsalud.org)
Structure of a trapped intermediate of calmodulin: calcium regulation of EF-hand proteins from a new perspective. (bvsalud.org)

These four genes were cloned from C. virginica and the three-dimensional structures of the proteins encoded by these four genes were fully characterized using homolog modeling methods. (figshare.com)
Although an acidified environment by increased atmospheric pCO 2 (1,000 ppm) did not result in significant effects on CvMC proliferation and apoptosis, lower environmental pH induced upregulations of all four calcium-binding protein genes in CvMCs. (figshare.com)
However, elevated pCO 2 concentrations enhanced the expression of these calcium-binding protein genes at the protein level. (figshare.com)
The four calcium-binding protein genes demonstrated responsive expression profiles to an acidified environment at both cellular and individual levels. (figshare.com)
It turned out that some of the genes Schekman had discovered in yeast coded for proteins corresponding to those Rothman identified in mammals, revealing an ancient evolutionary origin of the transport system. (blogspot.com)
This domain occurred 318 times on human genes ( 726 proteins). (umbc.edu)

Tryptic digests followed by internal sequence analyses of resulting peptide fragments revealed that the M(r) ≃ 14.1 kDa contained amino acid sequences that were identical to those of MRP-14, a 14 kDa neutrophil calcium-binding protein belonging to the S-100 protein family of calcium-binding proteins. (uab.edu)
A 13.2-kDa member of the S-100 family of calcium-binding proteins that can form homo- or heterocomplexes with CALGRANULIN A and a variety of other proteins. (bvsalud.org)

NaF stimulated accumulation of IP in a concentration-dependent manner, indicating that F- stimulated the putative G-protein Gp which couples various receptors to hydrolysis of phosphoinositides and mobilization of Ca++. (aspetjournals.org)
Identification of a putative calcium-binding protein as a dioxin-responsive gene in zebrafish and rainbow trout. (oregonstate.edu)
Two TCDD-responsive cDNAs, which encode putative calcium-binding proteins, have been isolated from zebrafish and rainbow trout. (oregonstate.edu)
XV" YOL105C 1 15 18 YOL105C "Putative integral membrane protein containing novel cysteine motif. (davidson.edu)

The three-dimensional structures of the magnesium- and manganese-bound forms of calbindin D(9k) were determined to 1.6 Å and 1.9 Å resolution, respectively, using X-ray crystallography. (ruc.dk)
Calcium binding was found to occur with positive cooperativity at physiological magnesium concentration. (ruc.dk)
On the other hand, magnesium is a cofactor that is required for the binding of vitamin D to its transport protein, vitamin D binding protein (VDBP). (reuther-hartmann.de)
Promotes magnesium levels & balances calcium intake, helping you feel calm. (reuther-hartmann.de)

The neurons investigated were immunoreactive for the anxiogenic peptide corticotropin-releasing factor (CRF-ir), the anxiolytic peptide neuropeptide Y (NPY-ir), and the calcium-binding proteins parvalbumin (PARV-ir) and calbindin (CALB-ir). (elsevier.com)

Abnormalities of proximal tubular function included reduced reabsorption of beta-2-microglobulin, retinol binding protein, calcium and phosphate. (cdc.gov)

He is now trying to use these luminescent proteins to tag cells in humans and begin to think about ways to design cancer treatments using these proteins as an escort for targeted medicines. (lww.com)

This protein is found in basement membranes, which are thin, sheet-like structures that support cells in many tissues and help anchor cells to one another during embryonic development. (medlineplus.gov)
Novel protein phosphorylation site identification in spinach stroma membranes by titanium dioxide microcolumns and tandem mass spectrometry. (ox.ac.uk)
When studying vesicle transport in mammalian cells in the 1980s and 1990s, Rothman discovered that a protein complex enables vesicles to dock and fuse with their target membranes. (blogspot.com)
In the fusion process, proteins on the vesicles and target membranes bind to each other like the two sides of a zipper. (blogspot.com)

Phylogeny as a Guide to Structure and Function of Membrane Transport Proteins. (tcdb.org)

While many neurons in the dorsal and ventral subiculum projected to the mammillary bodies, these cells did not co-localize with the immunofluorescence of any of the three tested proteins. (frontiersin.org)
These calcium-binding proteins are expressed in specific subsets of neurons and often do not co-localize with one another, making them a useful tool for differentiating functional pathways (e.g. (frontiersin.org)
CaBP1 is a Ca 2+ binding protein that is widely expressed in neurons in the brain, retina, and cochlea. (nih.gov)
In neurons, most α-syn is acetylated at the N-terminus, and acetylation leads to a 10-fold increase in binding strength for the α-syn peptide (KD = 35 ± 10 μM). (rcsb.org)
When neurons become active, they rapidly take up calcium from their environment. (mit.edu)

The SMOC1 gene provides instructions for making a protein called secreted modular calcium-binding protein 1 (SMOC-1). (medlineplus.gov)
Mutations in the SPARC-related modular calcium-binding protein 1 gene, SMOC1, cause waardenburg anophthalmia syndrome. (medlineplus.gov)
Although OA is known to inhibit the shell deposition in mollusks, the impact of OA on the gene regulation of calcium deposition remains unknown. (figshare.com)
TCDD elicits its toxicity through aryl hydrocarbon receptor (AhR)-mediated modulation of gene regulation, increasing intracellular free calcium, and inducing calcium-mediated apoptosis in cell culture. (oregonstate.edu)
Taken together, these findings demonstrate in zebrafish and rainbow trout that dioxin increases expression of this EF-hand calcium-binding protein gene in a tissue-dependent fashion. (oregonstate.edu)
He searched an online database and was shocked to find a new paper in the journal Gene on the cloning of the protein - by Dr. Prasher. (lww.com)
High-throughput gene microarray and bioinformatic analysis have enabled us to screen molecular markers among healthy individuals and patients, which provides novel perceptions into diseases at multiple levels ranging from the variation of copy number at the genome level to gene expression at transcriptome and protein level, and even epigenetic alterations [ 7 ] . (researchsquare.com)
The SPARC-related modular calcium binding protein 2 (SMOC2) gene polymorphism in primary glaucoma: a case-control study. (cdc.gov)
Asbestos induces nuclear factor kappa B (NF-kappa B) DNA-binding activity and NF-kappa B-dependent gene expression in tracheal epithelial cells. (cdc.gov)
The effects of asbestos (1332214) on nuclear-factor-kappa-B (NF- kappa-B) DNA binding activity and NF-kappa-B dependent gene expression were examined. (cdc.gov)
Transfection studies using the calcium phosphate coprecipitation technique were conducted in order to measure NF- kappa-B dependent gene expression. (cdc.gov)
The authors conclude that asbestos induces NF-kappa-B DNA binding activity and NF-kappa-B dependent gene expression, both of which may be involved in the development of asbestos induced lung cancers. (cdc.gov)

NMR structures of protein-protein complexes nowadays available could efficiently be exploited for further structure-based drug design/virtual screening processes employed to design small molecule inhibitors of protein-protein interactions. (biomedcentral.com)
Indeed, limitations in describing potential small-molecule binding sites have been noted when using static structures of either the unbound protein or the protein-protein complex [ 6 ]. (biomedcentral.com)
Neuroinflammatory markers, such as ionized calcium binding adaptor molecule 1 (Iba-1), glial fibrillary acidic protein (GFAP), gp91phox and inducible nitric oxide synthase (iNOS), were measured in the nigrostriatal system. (springer.com)

These include lead's ability to inhibit or mimic the actions of calcium (which can affect calcium-dependent or related processes) and to interact with proteins (including those with sulfhydryl, amine, phosphate, and carboxyl groups) [ATSDR 2010]. (cdc.gov)
The concept is a biphasic construct consisting of a porous, osteoconductive chitosan-calcium phosphate scaffold supporting a layer of neocartilage formed by marrow-derived mesenchymal stem cells. (openorthopaedicsjournal.com)
Our goal is to create a bilayered construct which consists of an osteoconductive chitosan-calcium phosphate scaffold underlying a layer of neocartilage formed bymesenchymal stem cells (MSCs) through self-assembly. (openorthopaedicsjournal.com)
No matter what method you use, it is important to ensure that your water contains enough calcium and phosphate. (soloseries.org)

Results indicate that intracranial hOEC transplantation has potential value as a novel strategy for treating SCA3, and the protein levels of tryptophan hydroxylase 2, the rate-limiting enzyme for serotonin synthesis in the cerebellum, and ryanodine receptor (RYR) increased in mice that received intrac Ranodine receptors transplantation. (semanticscholar.org)
Recently three orphan G-protein coupled receptors, RAIG1, GPRC5B and GPRC5C, with homology to members of family C (metabotropic glutamate receptor-like) have been identified. (ku.dk)
In an attempt to delineate the signal transduction pathway(s) of the orphan receptors, a series of chimeric receptors containing the amino terminal domain of the calcium sensing receptor or metabotropic glutamate receptor subtype 1, and the seven transmembrane domain of the orphan receptors were constructed and tested in binding and functional assays. (ku.dk)
17] Moreover, it has been suggested that an extracellular calcium-sensing receptor (CaSR) also contributes to the rise in intracellular calcium concentration. (hardmix.net)
Function as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. (dimabio.com)
Interaction of organochlorine compounds with thyroid receptor, transthyretin, and thyroid-binding globulin. (cdc.gov)

Egg shell quality, medullary bone ash, intestinal calcium and phosphorus absorption, and calcium-binding protein in phosphorus-deficient hens. (agri.gov.il)
He showed in chickens that blood levels of calcium and phosphorus depended both on vitamin A and K2, and that the two had synergistic effects on mineral absorption. (skeftomai.gr)
The levels of sodium, potassium, phosphorus, calcium and zinc were similar between the groups. (scielo.br)
The nutrient phytotic acid binds to the phosphorus found in beans and grains. (soloseries.org)

Proteins to which calcium ions are bound. (bvsalud.org)
Once Ca 2+ ions are bound to the three Ca 2+ -binding sites in aequorin, the protein is converted into an oxygenase. (biomedcentral.com)

The sarcomeres contain a number of proteins, among them are alpha actinin, which is the major constituent of the Z-band, and actin and myosin, which are the major components of the thin and thick filaments, respectively. (medscape.com)
Actin binding domains present in duplicate at the N-termini of spectrin-like proteins (including dystrophin, alpha-actinin). (embl.de)
A number of actin-binding proteins, including spectrin, alpha-actinin and fimbrin, contain a 250 amino acid stretch called the actin binding domain (ABD). (embl.de)

Although the derived amino acid sequence for rat ICaBP differed from the bovine and porcine sequences by 16 and 14 residues, respectively, all the residues of each calcium-binding site met the proposed requirements of the 'EF hand' theory. (nyu.edu)
The broadening is much reduced when binding a peptide consisting of the first 19 residues of α-syn. (rcsb.org)
The alignment of the PLA2 regions of representatives of 5 protoparvovirus species show the calcium-binding region and catalytic residues in Tusavirus. (cdc.gov)
STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. (umbc.edu)

2016, Thesis, Calcium-Dependent Membrane-Binding and Localization of Copine Proteins in Dictyostelium. (cmich.edu)
Gelation factor (ABP120) is one of the principal actin-cross-linking proteins of Dictyostelium discoideum. (embl.de)

The biologic function of LKB1 includes the regulation of downstream kinases, including adenosine monophosphate-activated protein kinase (AMPK) and the related kinases (microtube affinity-regulating kinase [MARK] 1 through MARK4 and brain-specific kinase/synapses of the amphid-defective kinase [Brsk/SAD]), which are involved in cellular metabolic regulation-stress response and cellular polarity, the latter through tubulin stabilization, tight junction formation, and E-cadherin localization. (medscape.com)
The various markers that enable assessment of the progression of preneoplastic lesions to spindle cell carcinoma include the p16 protein, which halts the cell cycle and induces apoptosis by pRb-mediated phosphorylation of cyclin-dependent kinase 4 (CDK4). (bvsalud.org)
Rapamycin inhibits protein kinase C activity and stimulates Na+ transport in A6 cells. (lclabs.com)
Catalytic domain of the Protein Serine/Threonine Kinase, Atypical Protein Kinase C. Serine/Threonine Kinases (STKs), Atypical Protein Kinase C (aPKC) subfamily, catalytic (c) domain. (umbc.edu)
The aPKC subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. (umbc.edu)

Calcium-binding protein and calcium absorption in the laying quail (Coturnix coturnix japonica). (agri.gov.il)
It binds to and prevents the absorption of various minerals, and high phytic acid diets have the potential to cause nutrient deficiencies. (marksdailyapple.com)
Low protein intake has been reported to reduce calcium absorption in the body, adversely affecting bone formation and increasing the chances of a breakdown. (saqshamortho.com)

Phylogenetic characterization of transport protein superfamilies: superiority of SuperfamilyTree programs over those based on multiple alignments. (tcdb.org)
Modification-specific proteomics of plasma membrane proteins: identification and characterization of glycosylphosphatidylinositol-anchored proteins released upon phospholipase D treatment. (ox.ac.uk)

Using the protein sequences of these receptors as queries we identified overlapping expressed sequence tags which were predicted to encode an additional subtype. (ku.dk)

We will discuss fluorescence as a general language used to read out biological phenomena as diverse as protein localization, membrane tension, surface phenomena, and enzyme activity. (coursera.org)

Intestinal and uterine calcium-binding protein in laying hens during different stages of egg formation. (agri.gov.il)
Intestinal and uterine calcium binding protein (CaBP) was measured in hens during egg shell calcification, or uterine inactivity, using an immunoassay technique. (agri.gov.il)
The presence of chronic diarrhea or intestinal disease (eg, Crohn disease, sprue, chronic pancreatitis) suggests the possibility of hypocalcemia due to malabsorption of calcium and/or vitamin D. (medscape.com)
Sequence of rat intestinal vitamin D-dependent calcium-binding protein derived from a cDNA clone. (nyu.edu)
We have recently reported molecular cloning of the cDNA synthesized from rat duodenal mRNA-encoding intestinal calcium-binding protein (ICaBP), a vitamin D 3 -induced protein (Desplan, C., Thomasset, M., and Moukhtar, M.S. (1983) J. Biol. (nyu.edu)
Dive into the research topics of 'Sequence of rat intestinal vitamin D-dependent calcium-binding protein derived from a cDNA clone. (nyu.edu)

Human S100Z Protein is a recombinant Human protein produced in E. coli using Prokaryotic expression. (abbexa.com)
A Novel Marker for Purkinje Cells, Ribosomal Protein MPS1/S27: Expression of MPS1 in Human Cerebellum. (semanticscholar.org)
As shown in Physique?1B mRNA expression of and the protein level of HPCA were markedly increased under differentiation conditions. (brain-tumor-cancer-information.com)
We hypothesized that differential protein expression was responsible for functional differences between the neutrophil subtypes. (uab.edu)
After the controlled-labeling of proteins during the induction of strobilar development, we identified modifications in protein expression. (cdc.gov)
According to recent researches, abnormal expression of S100 protein is often related to tumor, including breast tumor. (who.int)
This paper summarizes the expression situation of S100 proteins in breast tumor as well as its effects on metastasis and prognosis of breast tumor. (who.int)
Theoretical splicing for expression of viral protein (VP) 1 is shown. (cdc.gov)
Signaling involves calcium influx, culminating in the expression of TNF-alpha. (dimabio.com)

Aquaporins are transmembrane water permeable proteins involved in transcellular water flow. (adejournal.com)

Description: A sandwich quantitative ELISA assay kit for detection of Human S100 Calcium Binding Protein B (S100B) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. (elisareagents.com)
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse S100 Calcium Binding Protein B (S100B) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids. (elisareagents.com)
In a patient with hypocalcemia, measurement of the serum albumin is essential to distinguish true hypocalcemia, which involves a reduction in ionized serum calcium, from factitious hypocalcemia, meaning decreased total, but not ionized, calcium. (medscape.com)
To correct for hypoalbuminemia, add 0.8 mg/dL to the total serum calcium for each 1.0 g/dL decrease in albumin below 4.0 g/dL. (medscape.com)
A serum calcium level less than 8.5 mg/dL or an ionized calcium level less than 1.0 mmol/L is considered hypocalcemia. (medscape.com)
Symptoms are nonspecific and are related to the severity and rate of change of the serum calcium level, although neurologic dysfunction is an uncommon feature with mild hypercalcemia-patients can experience slight difficulties in concentrating but also experience depression, confusion, and coma as the condition becomes more severe. (clevelandclinicmeded.com)
Symptoms of hypercalcemia ( Table 2 ) are nonspecific and are related to the severity and rate of change of the serum calcium level. (clevelandclinicmeded.com)
Elevated total serum calcium levels are associated with idiopathic hypercalcemia, vitamin D intoxication, hyperparathyroidism, sarcoidosis, pneumocystic carinii pneumonia, and blue diaper syndrome. (cdc.gov)
Serum Protein Electrophoresis (SPEP) is a test which separates out the various globulins. (impactcreates.net)

Ied over 1000 proteins across seven independent experiments with direct or indirect relationships to LMP1. (ck2inhibitor.com)

The SMOC-1 protein also likely promotes the maturation (differentiation) of cells that build bones, called osteoblasts. (medlineplus.gov)
Secretome analysis of human BMSCs and identification of SMOC1 as an important ECM protein in osteoblast differentiation. (medlineplus.gov)
Another protein, calgranulin A (Cal A), is involved in the regulation of several cell processes, including the cell cycle and cell differentiation. (bvsalud.org)
Cystatin A (Cys A), a cysteine protease inhibitor, is a precursor of proteins involves in keratinocyte keratinization, and is expressed during the late phase of differentiation of these cells. (bvsalud.org)
12], Keratinocyte differentiation throughout the epidermis is in part mediated by a calcium gradient, increasing from the stratum basale until the outer stratum granulosum, where it reaches its maximum, and decreasing in the stratum corneum. (hardmix.net)
This calcium gradient parallels keratinocyte differentiation and as such is considered a key regulator in the formation of the epidermal layers. (hardmix.net)

abstract = "The flagellar calcium-binding protein (FCaBP) of Trypanosoma cruzi is localized to the flagellar membrane in all life cycle stages of the parasite. (northwestern.edu)

The total plasma calcium level, therefore, must be corrected for the albumin level. (clevelandclinicmeded.com)
Normal calcium levels range from 8.5 to 10.5 mg/day, assuming an albumin level of 4.5 g/dL. (clevelandclinicmeded.com)
The calcium concentration [Ca] usually changes by 0.8 mg/dL for every 1.0-g/dL change in plasma albumin concentration. (clevelandclinicmeded.com)
Acidosis decreases the amount of calcium bound to albumin whereas alkalosis increases the bound fraction of calcium. (clevelandclinicmeded.com)
Albumin is the major protein in the blood. (impactcreates.net)
A large portion of the calcium in the blood is bound to albumin. (impactcreates.net)
What is important is "free calcium", so a mildly low calcium combined with a low albumin is less of a problem for heart and nerves. (impactcreates.net)
We calculate the globulin level by subtracting albumin from "total protein" when it is not reported separately. (impactcreates.net)

3], Elevation of extracellular calcium concentrations induces an increase in intracellular free calcium concentrations. (hardmix.net)

Certain gut flora can actually turn phytic acid into inositol , preventing mineral-binding and releasing a nutrient involved in mood regulation and insulin sensitivity. (marksdailyapple.com)
The results are discussed in terms of feedback regulation of transducer channels mediated by Ca 2+ binding at two intracellular sites. (jneurosci.org)
Conclusion: p63, p16, MIB, Cal A, Cys A are markedly expressed and p16 is strongly suppressed in oral cavity tumors, which suggests that the latter protein may play a role in negative regulation of cell cycle progression. (bvsalud.org)

IMSEAR at SEARO: S100 protein in breast tumor. (who.int)
Li F, Men X, Zhang W. S100 protein in breast tumor. (who.int)
Accumulating investigations focused on the role of S100 proteins in breast tumor development and metastasis. (who.int)
our data suggest that overexpression of peroxiredoxin-2, annexin A2, and heat shock protein beta-1 was correlated with tumor invasion, metastasis, and poor prognosis, and therefore, these proteins may serve as potential diagnostic and therapeutic biomarkers. (ewmccall.com)
The p63 protein, a homologue of p53, may be associated with tumor formation in the epithelial tissue, acting as an oncogene 11,12 . (bvsalud.org)

Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins including RAET1A, RAET1B, RAET1C, RAET1D, RAET1E, H60 and MULT1. (dimabio.com)

zinc finger protein 451 [So. (gsea-msigdb.org)

Miembro de 13,2 kDa de la familia S-100 de las proteínas de unión al calcio que pueden formar homo o heterocomplejos con la CALGRANULINA A y una variedad de otras proteínas. (bvsalud.org)

Normal variations are observed according to a person's age and sex, the time of day, and diet, particularly protein intake. (cdc.gov)
However, extremely high protein intake is also harmful to your body as it leaches calcium from your bones. (saqshamortho.com)

As a result, we found proteins that are involved in important processes during development, such as energy metabolism, control pathways and cellular communication. (cdc.gov)
additionally, itraconazole can inhibit the metabolism of calcium channel blockers. (medscape.com)

Free calcium" is not attached to proteins. (medlineplus.gov)
An ionized calcium test measures only the "free calcium" in your blood that isn't attached to proteins. (medlineplus.gov)

Hippocalcin (HPCA) is a calcium-binding proteins that is limited to nervous tissues and plays a part in neuronal activity. (brain-tumor-cancer-information.com)

They can act as transport proteins, regulator proteins, or activator proteins. (bvsalud.org)

The proteins responsible for the key molecular events leading to the structural changes between the developmental stages of Echinococcus granulosus remain unknown. (cdc.gov)
The protein has a predicted molecular mass of 42.6 kDa after removal of the signal peptide. (dimabio.com)

What if a bioluminescent protein could cast its light in an organism that was already transparent? (lww.com)

Guanine nucleotide binding proteins may modulate gating of calcium channels in vascular smooth muscle. (aspetjournals.org)

Following exposure, nuclear protein extracts were analyzed for enhanced NF-kappa-B DNA binding activity using a gel mobility shift assay. (cdc.gov)
Multiple gel shift complexes, competitively blocked by excesses of NF-kappa-B, were observed in the nuclear protein extracts of crocidolite exposed HTE cells. (cdc.gov)
AMMECR nuclear protein 1 [S. (gsea-msigdb.org)
XIII" YMR047C 3 13 3 YMR047C "Nuclear pore complex protein that is member of GLFG repeat-containing family of nucleoporins and is,XIII" YMR049C 3 13 4 YMR049C "Ymr049cp,XIII" YMR051C 3 13 5 YMR051C "TyA Gag protein. (davidson.edu)

Experiments using buffers with different Ca 2+ -binding rates or dissociation constants indicated that the speed of adaptation and the resting open probability of the transducer channels could be differentially regulated and imply that the endogenous buffer must be a fast, high-affinity buffer. (jneurosci.org)
It binds two calcium ions with high affinity. (ewmccall.com)

The total calcium level is low in patients with low levels of binding proteins (hypoalbuminemia) and higher in those with high levels of binding proteins. (clevelandclinicmeded.com)

STK11/LKB1 encodes a 433 amino acid ubiquitously expressed protein with a central catalytic domain and regulatory N- and C-terminal domains. (medscape.com)

Moreover, Ca v 1-mediated Ca 2+ signals and phosphorylation of cAMP-response element binding protein were reduced in C-KO SGNs compared to WT SGNs. (nih.gov)

The aim was to extend these connectional analyses to three calcium-binding proteins, PV, CB, and CR. (frontiersin.org)
Five nutritional components were measured: calcium, iron, protein, vitamin A and vitamin C. In previous analyses of these data, the sample mean vector was calculated. (psu.edu)

Description: A sandwich quantitative ELISA assay kit for detection of Mouse Tubulin Polymerization Promoting Protein (TPPP) in samples from tissue homogenates or other biological fluids. (1elisakits.com)
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Tubulin Polymerization Promoting Protein (TPPP) in tissue homogenates, cell lysates and other biological fluids. (1elisakits.com)
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Tubulin Polymerization Promoting Protein (TPPP) in samples from tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. (1elisakits.com)

James Rothman unravelled protein machinery that allows vesicles to fuse with their targets to permit transfer of cargo. (blogspot.com)

A normal extracellular calcium concentration is necessary for normal neuromuscular function. (clevelandclinicmeded.com)

We used different protein tags that allowed for the visualization and purification of proteins produced specifically after the induction of strobilar development to identify proteins that might be involved in this process (temporally controlled and context-dependent). (cdc.gov)

The zebrafish and rainbow trout sequences are 88% similar to each other at the amino acid level and are orthologs of the human S100A4 calcium-binding protein. (oregonstate.edu)
It encodes a protein of about 68 kDa that consists of eight 68-amino acid repeats separated by linking sequences of variable lengths. (creativebiomart.net)

The binding of the myosin head to the actin filaments, together with the concomitant hydrolysis of ATP for energy, results in the contraction of the sarcomeres that in turn causes contraction of the entire muscle, resulting in movement (or the development of isometric tension that permits us to hold objects or resist being pulled). (medscape.com)

The shell deposition mechanism is initiated in the early stages of development and is dependent upon the concentration and availability of calcium carbonate ions. (figshare.com)
In turtle hair cells, the time course of adaptation and the fraction of transducer current activated at the position of the unperturbed bundle depend both on external Ca 2+ concentration and on the level of intracellular calcium buffer ( Ricci and Fettiplace, 1997 , 1998 ). (jneurosci.org)
The mechanisms of benefit involve alkalinization to override the TCA s myocardial sodium channel blockade and boost protein binding so the drug doesn t cause additional problems, along with an increase in the extracellular sodium channel concentration to improve the cross-channel gradient. (crashingpatient.com)

Anatomy21

Organisms13

Diseases2

Chemicals and Drugs140

Analytical, Diagnostic and Therapeutic Techniques and Equipment30

Phenomena and Processes46

Disciplines and Occupations3

Technology, Industry, Agriculture1

Information Science3

Health Care1

Endocytosis: EH domains lend a hand. (1/7886)

Binding of the G domains of laminin alpha1 and alpha2 chains and perlecan to heparin, sulfatides, alpha-dystroglycan and several extracellular matrix proteins. (2/7886)

Identification of a novel family of targets of PYK2 related to Drosophila retinal degeneration B (rdgB) protein. (3/7886)

Phospholamban is present in endothelial cells and modulates endothelium-dependent relaxation. Evidence from phospholamban gene-ablated mice. (4/7886)

A novel interaction mechanism accounting for different acylphosphatase effects on cardiac and fast twitch skeletal muscle sarcoplasmic reticulum calcium pumps. (5/7886)

Oligosaccharide modification in the early secretory pathway directs the selection of a misfolded glycoprotein for degradation by the proteasome. (6/7886)

Complete exon-intron organization of the mouse fibulin-1 gene and its comparison with the human fibulin-1 gene. (7/7886)

Function of WW domains as phosphoserine- or phosphothreonine-binding modules. (8/7886)

S100 Calcium Binding Protein G

Calcium-Binding Proteins

Calbindins

Calbindin 1

Calbindin 2

Parvalbumins

S100 Proteins

EF Hand Motifs

Calcium

Calmodulin

Recoverin

Calgranulin B

Calsequestrin

Calgranulin A

Salamandra

Fluorescamine

Molecular Sequence Data

Calcium Signaling

Amino Acid Sequence

Collodion

Binding Sites

Protein Binding

Calcium Radioisotopes

Entamoeba histolytica

Calcium Channels

Egtazic Acid

Base Sequence

Sarcoplasmic Reticulum

Protein Conformation

Calcium, Dietary

Rabbits

Protein Structure, Tertiary

Muscles

Spectrometry, Fluorescence

Poly(A)-Binding Proteins

Sequence Homology, Amino Acid

Calcium Isotopes

RNA, Messenger

Troponin C

Models, Molecular

Calcitriol

S100 Calcium Binding Protein beta Subunit

Molecular Weight

Cattle

Carrier Proteins

Immunohistochemistry

Cloning, Molecular

Chickens

Calcium Chloride

Nerve Tissue Proteins

Calcium Carbonate

Kinetics

Cell Line

Gene Expression Regulation

Neurons

Sequence Homology, Nucleic Acid

Terbium

Rats, Sprague-Dawley

Troponin

Calcium Phosphates

Magnesium

Tacrolimus Binding Proteins

Poly(A)-Binding Protein I

Recombinant Proteins

Calcium Channels, L-Type

Mutation

Hippocalcin

Insulin-Like Growth Factor Binding Proteins

Cells, Cultured

DNA-Binding Proteins

Calcium Oxalate

Chelating Agents

Ytterbium

Hydrogen-Ion Concentration

Lanthanum

Calcium Gluconate

Circular Dichroism

RNA-Binding Proteins

Cations, Divalent

Microfilament Proteins