Calcitriol
The physiologically active form of vitamin D. It is formed primarily in the kidney by enzymatic hydroxylation of 25-hydroxycholecalciferol (CALCIFEDIOL). Its production is stimulated by low blood calcium levels and parathyroid hormone. Calcitriol increases intestinal absorption of calcium and phosphorus, and in concert with parathyroid hormone increases bone resorption.
Receptors, Calcitriol
Proteins, usually found in the cytoplasm, that specifically bind calcitriol, migrate to the nucleus, and regulate transcription of specific segments of DNA with the participation of D receptor interacting proteins (called DRIP). Vitamin D is converted in the liver and kidney to calcitriol and ultimately acts through these receptors.
Calcium Channel Agonists
Agents that increase calcium influx into calcium channels of excitable tissues. This causes vasoconstriction in VASCULAR SMOOTH MUSCLE and/or CARDIAC MUSCLE cells as well as stimulation of insulin release from pancreatic islets. Therefore, tissue-selective calcium agonists have the potential to combat cardiac failure and endocrinological disorders. They have been used primarily in experimental studies in cell and tissue culture.
Hyperparathyroidism, Secondary
Parathyroid Hormone
A polypeptide hormone (84 amino acid residues) secreted by the PARATHYROID GLANDS which performs the essential role of maintaining intracellular CALCIUM levels in the body. Parathyroid hormone increases intracellular calcium by promoting the release of CALCIUM from BONE, increases the intestinal absorption of calcium, increases the renal tubular reabsorption of calcium, and increases the renal excretion of phosphates.
Ergocalciferols
Vitamins
Parathyroid Glands
Phosphorus
Vitamin D
A vitamin that includes both CHOLECALCIFEROLS and ERGOCALCIFEROLS, which have the common effect of preventing or curing RICKETS in animals. It can also be viewed as a hormone since it can be formed in SKIN by action of ULTRAVIOLET RAYS upon the precursors, 7-dehydrocholesterol and ERGOSTEROL, and acts on VITAMIN D RECEPTORS to regulate CALCIUM in opposition to PARATHYROID HORMONE.
Hypocalcemia
Calcium
A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.
Renal Osteodystrophy
Uremia
A clinical syndrome associated with the retention of renal waste products or uremic toxins in the blood. It is usually the result of RENAL INSUFFICIENCY. Most uremic toxins are end products of protein or nitrogen CATABOLISM, such as UREA or CREATININE. Severe uremia can lead to multiple organ dysfunctions with a constellation of symptoms.
25-Hydroxyvitamin D3 1-alpha-Hydroxylase
A mitochondrial cytochrome P450 enzyme that catalyzes the 1-alpha-hydroxylation of 25-hydroxyvitamin D3 (also known as 25-hydroxycholecalciferol) in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP27B1 gene, converts 25-hydroxyvitamin D3 to 1-alpha,25-dihydroxyvitamin D3 which is the active form of VITAMIN D in regulating bone growth and calcium metabolism. This enzyme is also active on plant 25-hydroxyvitamin D2 (ergocalciferol).
Hyperparathyroidism
A condition of abnormally elevated output of PARATHYROID HORMONE (or PTH) triggering responses that increase blood CALCIUM. It is characterized by HYPERCALCEMIA and BONE RESORPTION, eventually leading to bone diseases. PRIMARY HYPERPARATHYROIDISM is caused by parathyroid HYPERPLASIA or PARATHYROID NEOPLASMS. SECONDARY HYPERPARATHYROIDISM is increased PTH secretion in response to HYPOCALCEMIA, usually caused by chronic KIDNEY DISEASES.
Steroid Hydroxylases
Calcifediol
Pacific States
Vitamin D Response Element
Cholecalciferol
Hypoparathyroidism
A condition caused by a deficiency of PARATHYROID HORMONE (or PTH). It is characterized by HYPOCALCEMIA and hyperphosphatemia. Hypocalcemia leads to TETANY. The acquired form is due to removal or injuries to the PARATHYROID GLANDS. The congenital form is due to mutations of genes, such as TBX1; (see DIGEORGE SYNDROME); CASR encoding CALCIUM-SENSING RECEPTOR; or PTH encoding parathyroid hormone.
Osteomalacia
Renal Dialysis
Phosphorus, Dietary
Phosphorus used in foods or obtained from food. This element is a major intracellular component which plays an important role in many biochemical pathways relating to normal physiological functions. High concentrations of dietary phosphorus can cause nephrocalcinosis which is associated with impaired kidney function. Low concentrations of dietary phosphorus cause an increase in calcitriol in the blood and osteoporosis.
Bone Density Conservation Agents
Rickets
Disorders caused by interruption of BONE MINERALIZATION manifesting as OSTEOMALACIA in adults and characteristic deformities in infancy and childhood due to disturbances in normal BONE FORMATION. The mineralization process may be interrupted by disruption of VITAMIN D; PHOSPHORUS; or CALCIUM homeostasis, resulting from dietary deficiencies, or acquired, or inherited metabolic, or hormonal disturbances.
Hypophosphatemia, Familial
An inherited condition of abnormally low serum levels of PHOSPHATES (below 1 mg/liter) which can occur in a number of genetic diseases with defective reabsorption of inorganic phosphorus by the PROXIMAL RENAL TUBULES. This leads to phosphaturia, HYPOPHOSPHATEMIA, and disturbances of cellular and organ functions such as those in X-LINKED HYPOPHOSPHATEMIC RICKETS; OSTEOMALACIA; and FANCONI SYNDROME.
Calcium Carbonate
Bone and Bones
Astemizole
Osteocalcin
Vitamin K-dependent calcium-binding protein synthesized by OSTEOBLASTS and found primarily in BONES. Serum osteocalcin measurements provide a noninvasive specific marker of bone metabolism. The protein contains three residues of the amino acid gamma-carboxyglutamic acid (Gla), which, in the presence of CALCIUM, promotes binding to HYDROXYAPATITE and subsequent accumulation in BONE MATRIX.
Alkaline Phosphatase
Familial Hypophosphatemic Rickets
Kidney Failure, Chronic
The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION.
S100 Calcium Binding Protein G
A calbindin protein found in many mammalian tissues, including the UTERUS, PLACENTA, BONE, PITUITARY GLAND, and KIDNEYS. In intestinal ENTEROCYTES it mediates intracellular calcium transport from apical to basolateral membranes via calcium binding at two EF-HAND MOTIFS. Expression is regulated in some tissues by VITAMIN D.
Cholestanetriol 26-Monooxygenase
Receptors, Calcium-Sensing
A class of G-protein-coupled receptors that react to varying extracellular CALCIUM levels. Calcium-sensing receptors in the PARATHYROID GLANDS play an important role in the maintenance of calcium HOMEOSTASIS by regulating the release of PARATHYROID HORMONE. They differ from INTRACELLULAR CALCIUM-SENSING PROTEINS which sense intracellular calcium levels.
Vitamin D Deficiency
A nutritional condition produced by a deficiency of VITAMIN D in the diet, insufficient production of vitamin D in the skin, inadequate absorption of vitamin D from the diet, or abnormal conversion of vitamin D to its bioactive metabolites. It is manifested clinically as RICKETS in children and OSTEOMALACIA in adults. (From Cecil Textbook of Medicine, 19th ed, p1406)
Hydroxyprostaglandin Dehydrogenases
25-Hydroxyvitamin D 2
Hydroxycholecalciferols
Dose-Response Relationship, Drug
Fibroblast Growth Factors
A family of small polypeptide growth factors that share several common features including a strong affinity for HEPARIN, and a central barrel-shaped core region of 140 amino acids that is highly homologous between family members. Although originally studied as proteins that stimulate the growth of fibroblasts this distinction is no longer a requirement for membership in the fibroblast growth factor family.
Calcium Gluconate
Phosphorus Metabolism Disorders
Calbindins
Etidronic Acid
Kidneys, Artificial
Annexin A6
Calcium, Dietary
Pharmaceutical Vehicles
Alendronate
Renal Insufficiency, Chronic
Conditions in which the KIDNEYS perform below the normal level for more than three months. Chronic kidney insufficiency is classified by five stages according to the decline in GLOMERULAR FILTRATION RATE and the degree of kidney damage (as measured by the level of PROTEINURIA). The most severe form is the end-stage renal disease (CHRONIC KIDNEY FAILURE). (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002)
Calcimimetic Agents
Vitamin D regulates human ectocervical epithelial cell proliferation and insulin-like growth factor-binding protein-3 level. (1/2474)
The differentiation status of the cervical epithelial cell has an important influence on responsiveness to estrogens and progestins. Several agents, including glucocorticoids and retinoids, are known to influence cervical cell differentiation. However, the effects of vitamin D have not been examined. Vitamin D is known to regulate cell proliferation and gene expression in a variety of epithelial cells. In the present study we investigated the ability of 1alpha25-dihydroxyvitamin D3 (D3) to regulate cell proliferation and expression of insulin-like growth factor-binding protein-3 (IGFBP-3) in human ectocervical epithelial cells. ECE16-1, a non-tumorigenic cervical cell line, was growth inhibited by D3 with maximal inhibition at 1000 nM. IGFBP-3 levels increased in parallel with the growth inhibition. IGFBP-3 levels were half-maximally increased at approximately 10-100 nM and maximally increased (10- to 30-fold) at 1000 nM D3. These studies show that vitamin D regulates cervical epithelial cell gene regulation and cell proliferation and that IGFBP-3 may be an in vivo marker of vitamin D action in the cervix. (+info)22-oxacalcitriol suppresses secondary hyperparathyroidism without inducing low bone turnover in dogs with renal failure. (2/2474)
BACKGROUND: Calcitriol therapy suppresses serum levels of parathyroid hormone (PTH) in patients with renal failure but has several drawbacks, including hypercalcemia and/or marked suppression of bone turnover, which may lead to adynamic bone disease. A new vitamin D analogue, 22-oxacalcitriol (OCT), has been shown to have promising characteristics. This study was undertaken to determine the effects of OCT on serum PTH levels and bone turnover in states of normal or impaired renal function. METHODS: Sixty dogs were either nephrectomized (Nx, N = 38) or sham-operated (Sham, N = 22). The animals received supplemental phosphate to enhance PTH secretion. Fourteen weeks after the start of phosphate supplementation, half of the Nx and Sham dogs received doses of OCT (three times per week); the other half were given vehicle for 60 weeks. Thereafter, the treatment modalities for a subset of animals were crossed over for an additional eight months. Biochemical and hormonal indices of calcium and bone metabolism were measured throughout the study, and bone biopsies were done at baseline, 60 weeks after OCT or vehicle treatment, and at the end of the crossover period. RESULTS: In Nx dogs, OCT significantly decreased serum PTH levels soon after the induction of renal insufficiency. In long-standing secondary hyperparathyroidism, OCT (0.03 microg/kg) stabilized serum PTH levels during the first months. Serum PTH levels rose thereafter, but the rise was less pronounced compared with baseline than the rise seen in Nx control. These effects were accompanied by episodes of hypercalcemia and hyperphosphatemia. In animals with normal renal function, OCT induced a transient decrease in serum PTH levels at a dose of 0.1 microg/kg, which was not sustained with lowering of the doses. In Nx dogs, OCT reversed abnormal bone formation, such as woven osteoid and fibrosis, but did not significantly alter the level of bone turnover. In addition, OCT improved mineralization lag time, (that is, the rate at which osteoid mineralizes) in both Nx and Sham dogs. CONCLUSIONS: These results indicate that even though OCT does not completely prevent the occurrence of hypercalcemia in experimental dogs with renal insufficiency, it may be of use in the management of secondary hyperparathyroidism because it does not induce low bone turnover and, therefore, does not increase the risk of adynamic bone disease. (+info)Serum levels of 1,25-dihydroxyvitamin D, 24,25-dihydroxyvitamin D, and 25-hydroxyvitamin D in nondialyzed patients with chronic renal failure. (3/2474)
BACKGROUND: In patients with chronic renal failure (CRF), abnormalities in vitamin D metabolism are known to be present, and several factors could contribute to the abnormalities. METHODS: We measured serum levels of three vitamin D metabolites, 1,25(OH)2D, 24, 25(OH)2D and 25(OH)D, and analyzed factors affecting their levels in 76 nondialyzed patients with CRF (serum creatinine> 1.6 and < 9.0 mg/dl), 37 of whom had diabetes mellitus (DM-CRF) and 39 of whom were nondiabetic (nonDM-CRF). RESULTS: Serum levels of 1,25(OH)2D were positively correlated with estimated creatinine clearance (CCr; r = 0.429; P < 0.0001), and levels of 24,25(OH)2D were weakly correlated with CCr (r = 0.252, P < 0.05); no correlation was noted for 25(OH)D. Serum levels of all three vitamin D metabolites were significantly and positively correlated with serum albumin. Although there were no significant differences in age, sex, estimated CCr, calcium and phosphate between DM-CRF and nonDM-CRF, all three vitamin D metabolites were significantly lower in DM-CRF than in nonDM-CRF. To analyze factors influencing vitamin D metabolite levels, we performed multiple regression analyses. Serum 25(OH)D levels were significantly and independently associated with serum albumin, presence of DM and serum phosphate (R2 = 0.599; P < 0.0001). 24,25(OH)2D levels were significantly and strongly associated with 25(OH)D (beta = 0.772; R2 = 0.446; P < 0.0001). Serum 1,25(OH)2D levels were significantly associated only with estimated CCr (R2 = 0. 409; P < 0.0001). CONCLUSIONS: These results suggest that hypoalbuminemia and the presence of DM independently affect serum 25(OH)D levels, probably via diabetic nephropathy and poor nutritional status associated with diabetes, and that 25(OH)D is actively catalyzed to 24,25(OH)2D in CRF, probably largely via extrarenal 24-hydroxylase. Serum levels of 1,25(OH)2D were significantly affected by the degree of renal failure. Thus, this study indicates that patients with CRF, particularly those with DM, should receive supplements containing the active form of vitamin D prior to dialysis. (+info)1,25-Dihydroxyvitamin D3 enhances the susceptibility of breast cancer cells to doxorubicin-induced oxidative damage. (4/2474)
1,25-Dihydroxyvitamin D3 (1,25(OH)2D3), the hormonal form of vitamin D, has anticancer activity in vivo and in vitro. Doxorubicin exerts its cytotoxic effect on tumor cells mainly by two mechanisms: (a) generation of reactive oxygen species (ROS); and (b) inhibition of topoisomerase II. We studied the combined cytotoxic action of 1,25(OH)2D3 and doxorubicin on MCF-7 breast cancer cells. Pretreatement with 1,25(OH)2D3 resulted in enhanced cytotoxicity of doxorubicin. The average enhancing effect after a 72-h pretreatment with 1,25(OH)2D3 (10 nM) followed by a 24-h treatment with 1 microg/ml doxorubicin was 74+/-9% (mean +/- SE). Under these experimental conditions, 1,25(OH)2D3 on its own did not affect cell number or viability. 1,25(OH)2D3 also enhanced the cytotoxic activity of another ROS generating quinone, menadione, but did not affect cytotoxicity induced by the topoisomerase inhibitor etoposide. The antioxidant N-acetylcysteine slightly reduced the cytotoxic activity of doxorubicin but had a marked protective effect against the combined action of 1,25(OH)2D3 and doxorubicin. These results indicate that ROS are involved in the interaction between 1,25(OH)2D3 and doxorubicin. 1,25(OH)2D3 also increased doxorubicin cytotoxicity in primary cultures of rat cardiomyocytes. Treatment of MCF-7 cells with 1,25(OH)2D3 alone markedly reduced the activity, protein, and mRNA levels of the cytoplasmic antioxidant enzyme Cu/Zn superoxide dismutase, which indicated that the hormone inhibits its biosynthesis. This reduction in the antioxidant capacity of the cells could account for the synergistic interaction between 1,25(OH)2D3 and doxorubicin and may also suggest increased efficacy of 1,25(OH)2D3 or its analogues in combination with other ROS-generating anticancer therapeutic modalities. (+info)Convergence of transforming growth factor-beta and vitamin D signaling pathways on SMAD transcriptional coactivators. (5/2474)
Cell proliferation and differentiation are regulated by growth regulatory factors such as transforming growth factor-beta (TGF-beta) and the liphophilic hormone vitamin D. TGF-beta causes activation of SMAD proteins acting as coactivators or transcription factors in the nucleus. Vitamin D controls transcription of target genes through the vitamin D receptor (VDR). Smad3, one of the SMAD proteins downstream in the TGF-beta signaling pathway, was found in mammalian cells to act as a coactivator specific for ligand-induced transactivation of VDR by forming a complex with a member of the steroid receptor coactivator-1 protein family in the nucleus. Thus, Smad3 may mediate cross-talk between vitamin D and TGF-beta signaling pathways. (+info)Regulation of PiT-1, a sodium-dependent phosphate co-transporter in rat parathyroid glands. (6/2474)
A cDNA encoding an Na+-Pi co-transporter, termed rat PiT-1, has now been isolated from rat parathyroid. Expression of rat PiT-1 in Xenopus oocytes revealed that it possesses Na+-dependent Pi co-transport activity. The amount of PiT-1 mRNA in the parathyroid of vitamin D-deficient rats was reduced compared with that in normal animals, and increased markedly after administration of 1,25-dihydroxyvitamin D3. Furthermore, the abundance of PiT-1 mRNA in the parathyroid was much greater in rats fed a low-Pi diet than in those fed a high-Pi diet. Thus, rat PiT-1 may contribute to the effects of Pi and vitamin D on parathyroid function. (+info)Regulation of vitamin D action. (7/2474)
The control of gene transcription by vitamin D compounds is initiated by binding to the VDR, which enhances the receptor's ability to heterodimerize to RXR, interact with response elements in target genes and attract components of the transcriptional initiation complex. A number of factors are capable of influencing this process, including (i) the rate of uptake and catabolism of the ligand, (ii) the nature of the conformational change induced by a specific ligand, (iii) the cellular content of the VDR, (iv) post-translational modifications of the VDR and (v) the availability of other transcriptional components. Vitamin D analogues may affect these factors differently to 1,25(OH)2D3 to produce unique biological profiles that can be exploited for therapeutic use. (+info)Topical psoriasis therapy. (8/2474)
Psoriasis is a common dermatosis, affecting from 1 to 3 percent of the population. Until recently, the mainstays of topical therapy have been corticosteroids, tars, anthralins and keratolytics. Recently, however, vitamin D analogs, a new anthralin preparation and topical retinoids have expanded physicians' therapeutic armamentarium. These new topical therapies offer increased hope and convenience to the large patient population with psoriasis. (+info)
Direct inhibitory effect of calcitriol on parathyroid function (sigmoidal curve) in dialysis<...
Sequential versus combined treatment of human breast cancer cells with antiestrogens and the vitamin D analogue EB1089 and...
Comparison of the Effects of Daily and Intermittent-Dose Calcitriol on Serum Parathyroid Hormone and Ionized Calcium...
1,25 Dihydroxyvitamin D circulating levels, calcitriol administration, and incidence of acute rejection, CMV infection, and...
Enhancement of vasoconstrictor response by a noncalcemic analogue of vitamin D3. | Hypertension
Calcitriol Plus Dexamethasone in Treating Patients With Prostate Cancer That Has Not Responded to Hormone Therapy - Full Text...
23,25-Dihydroxyvitamin D3: a natural precursor in the biosynthesis of 25-hydroxyvitamin D3-26,23-lactone | PNAS
Social Network - Blog View - Order Low Price Calcitriol 0.25mg - Calcitriol Legal Purchase
ASCENT: Androgen Independent Prostate Cancer Study of Calcitriol Enhancing Taxotere - Full Text View - ClinicalTrials.gov
Calcitriol QuickView - Correlation Engine
Calcitriol manufacturer,Calcitriol supplier & exporter|A.S.Joshi & Company India
Effects of Cinacalcet and Concurrent Low-Dose Vitamin D on FGF23 Levels in ESRD | American Society of Nephrology
Calcitriol order cheap. Calcitriol Buy Stores » South Wedding Dreams Social Network - Welcome to the Wonderful World of Wedding...
Harga Calcitriol - Calcitriol 0.25 Mg To Iu
Effect of calcitriol on the production of T-cell-derived cytokines in psoriasis
The in vitro evaluation of 25-hydroxyvitamin D<sub>3</sub> and 19-nor-1α,25- dihydroxyvitamin D<sub>2</sub> as therapeutic...
Association of Oral Calcitriol with Improved Survival in Nondialyzed CKD | American Society of Nephrology
Hormonally active agents in the environment: a state-of-the-art review : Reviews on Environmental Health
Order online Calcitriol no RX. Safe online Calcitriol no RX
Order Calcitriol online - What Is The Most Reliable Canadian Pharmancy To Buy Calcitriol Online From The Us - Movimento pelas...
Calcitriol 0.5mcg Capsules - Summary
Its been proposed that cellular Ca2+ signals activate hormone secretion. polypeptide | Selective Inhibitors of Protein...
Cheap calcitriol pills free shipping
Calcitriol - DrugBank
Calcitriol Receptors
- Calcitriol Receptor
Summary Report | CureHunter
Generic Rocaltrol (Geldex) .025 ug 50 Caps, Calcitriol
Generic Rocaltrol (Geldex) .025 ug 50 Caps, Calcitriol
Global Calcitriol (CAS 32222-06-3) Market 2017: By Manufacturers, Regions, Type and Application, Forecast to 2022 | Business
63] A Sensitive Radioreceptor Assay for 1α,25-Dihydroxyvitamin D in Biological Fluid<...
Electromechanical effects of 1,25-dihydroxyvitamin D with antiatrial fibrillation activities<...
Total synthesis of 1α,25-dihydroxyvitamin D3 (calcitriol) through a Si-assisted allylic substitution - Chemical Communications ...
The Potential Role of Calcitriol Analogs in the Management of Breast Cancer.
Calcitriol - Dog
Generation of inositol phosphates, diacylglycerol and calcium fluxes in myoblasts treated with 1,25-dihydroxyvitamin D3 |...
Biological activity of 1 alpha, 25-dihydroxyvitamin D derivatives--24-epi-1 alpha, 25-dihydroxyvitamin D-2 and 1 alpha,25...
Phase I study of weekly DN-101, a new formulation of calcitriol, in patients with cancer<...
Calcitriol - Side Effects, Uses, Dosage, Overdose, Pregnancy, Alcohol | RxWiki
Sunshine hormone, vitamin D, may offer hope for treating liver fibrosis - Salk Institute for Biological Studies
1,25-Dihydroxyvitamin D<sub>3</sub>-induced alterations of lipid metabolism in human monocyte...
C-terminal proteolysis of the avian 1,25-dihydroxyvitamin D<sub>3</sub>...
Renal function during calcitriol therapy in chronic renal failure
calcitriol (vitamin D3) | PeaceHealth
Purchase Calcitriol Online From Canada, Calcitriol Overnight American Express - Dissect
Avet announces launch of Calcitriol soft gel capsules - Avet Pharmaceuticals Inc.
CD22 | FLT3 tyrosine kinase inhibitors in acute myeloid leukemia
Mapping Variation in Cellular and Transcriptional Response to 1,25-Dihydroxyvitamin D3 in Peripheral Blood Mononuclear Cells.
Calcitriol | Best On Health
cheaper version of calcitriol @ where can i buy calcitriol 0,25 mg online now - Moes Tavern
Effect of calcitriol on bone loss after cardiac or lung transplantation<...
Treatment of secondary hyperparathyroidism with vitamin D derivatives and calcimimetics before and after start of dialysis :...
Long term oral calcitriol in patients on chronic hemodialysis - ORA - Oxford University Research Archive
The vitamin D receptor is a Wnt effector that controls hair follicle differentiation and specifies tumor type in adult...
Plasma 1,25(OH)2 vitamin D measured by radioimmunoassay and cytosol radioreceptor assay in normal subjects and patients with...
Letter by Zitterman et al Regarding Article, Calcium/Vitamin D Supplementation and Cardiovascular Events | Circulation
1,25-Dihydroxyvitamin D, Serum -
Wyoming Medical Center
1 alpha,25-Dihydroxyvitamin D (calcitriol) inhibits the invasiveness of human prostate cancer cells. | Cancer Epidemiology,...
Microsoft word - rocaltrol pi august 2010
The Wnt antagonist DICKKOPF-1 gene is induced by 1α,25-dihydroxyvitamin D3 associated to the differentiation of human colon...
The dichotomy in the effects of 1,25 dihydroxyvitamin D<sub>3</sub> and 24,25-dihydroxyvitamin D<sub>3</sub> on bone γ...
Lirias: Immunoregulation by 1,25-dihydroxyvitamin D3: basic concepts
Plus it
Cancers | Free Full-Text | Gene Regulatory Scenarios of Primary 1,25-Dihydroxyvitamin D3 Target Genes in a Human Myeloid...
WildAlchemist: Vitamin D revealed to be miracle anti-cancer drug with astonishing chemical properties
Cell membrane proteomic analysis identifies proteins differentially expressed in osteotropic human breast cancer cells. -...
calcitriol - Corporate On-Site Therapies
Hypercalciuria due to combined growth hormone and calcitriol therapy in uremia: effects of growth hormone on mineral...
CUTANEOUS COMPOSITION COMPRISING VITAMIN D ANALOGUE AND A MIXTURE OF SOLVENT AND SURFACTANTS - Patent application
Vitamin D
Indian Patents. 247527:GEMINI VITAMIN D3 COMPOUND
Vitamin D receptor expression in peripheral blood mononuclear cells is inversely associated with disease activity and...
BeatingCancerCenter - The Di Bella Method - Anti-oestrogen resistant human breast cancer cell lines are more sensitive towards...
Publications | College of Veterinary Medicine
Calcifediol-loaded liposomes for local treatment of pulmonary bacterial infections. | LJMU Research Online
Nutrients | Free Full-Text | Molecular Link between Vitamin D and Cancer Prevention | HTML
Oral Paricalcitol May Have Similar Efficacy to Oral Calcitriol - Renal and Urology News
Maturation state determines the response of osteogenic cells to surface roughness and 1,25-dihydroxyvitamin D<sub>3<...
Dihydroxyvitamin D3, 1 α, 25-[26,27-3H]-, 5µCi (185kBq) | PerkinElmer
Nuclear Receptor/Transcription Factor | DC Chemicals
Hypercalcemia, Hodgkins Disease, and Calcitriol | Annals of Internal Medicine | American College of Physicians
Vitamin D-sensitive calcium signaling in depression (Homo sapiens) - WikiPathways
Can you overdose on calcitriol?
BeatingCancerCenter - The Di Bella Method - Role of vitamin D receptor in the antiproliferative effects of calcitriol in tumor...
Private MD Health News - Vitamin D Deficiency-Diagnosis and Treatment News
1.25 dihydroxyvitamin D3 receptor exist of osteoclast precursors<...
Plus it
1,25-Dihydroxyvitamin D3 prevented allergic asthma in a rat model...: Ingenta Connect
1α,25-dihydroxyvitamin D3 promotes osteogenic activity and downregulates proinflammatory cytokine expression in human...
clinical Significance of the New Vitamin B 12 and Intrinsic Factor Research]. - Semantic Scholar
0.25 mcg of calcitriol is eequivalent to how many i.u. of cholecalciferol?
Hall of Record: May 2008
Patent US4973584 - Novel 1α-hydroxyvitamin D2 epimer and derivatives - Google Patents
Parathyroid hormone
Carrillo-López N, Fernández-Martín JL, Cannata-Andía JB (2009-04-01). "[The role of calcium, calcitriol and their receptors in ... calcitriol), which is released into the circulation. This latter form of vitamin D is the active hormone which stimulates ... Calcitriol Increase in serum phosphate. Fibroblast growth factor-23 (FGF23) is produced in osteoblasts (from bone) in response ...
Hoffmann-La Roche
Rocaltrol (calcitriol), for osteoporosis and hypocalcaemia. Rocephin (ceftriaxone), a broad-spectrum cephalosporin antibiotic. ...
Vitamin D5
... is a form of vitamin D. Calcitriol (Vitamin D3) analogues have been proposed for use as antitumor agents. Studies on ... The motive to develop 1α-Hydroxyvitamin D5 stemmed from the tendency of calcitriol, or 1,25 dihydroxy vitamin D3, a natural ... Thus, the therapeutic effects of 1α-Hydroxyvitamin D5 as a potential antitumor agent without the side effects of calcitriol ... Beer, Tomasz M.; Myrthue, Anne (March 2004). "Calcitriol in cancer treatment: from the lab to the clinic". Molecular Cancer ...
Falecalcitriol
... (INN) is an analog of calcitriol. It has a higher potency both in vivo and in vitro systems, and longer duration ...
Mater Misericordiae University Hospital
Caniggia A, Nuti R, Lore F, Martini G, Turchetti V, Righi G (April 1990). "Long-term treatment with calcitriol in ...
Endoscopy
"Long-term treatment with calcitriol in postmenopausal osteoporosis". Metabolism. 39 (4 Suppl 1): 43-9. doi:10.1136/bmj.1.223. ...
Vitamin D
See also: Vitamin D receptor and Calcitriol. Calcitriol enters the target cell and binds to the vitamin D receptor in the ... Calcifediol is then converted by the kidneys to calcitriol, the biologically active form of vitamin D. Calcitriol circulates as ... to form calcitriol (1,25-dihydroxycholecalciferol, 1,25(OH)2D). The conversion of calcifediol to calcitriol is catalyzed by the ... Calcitriol itself is auto-regulated in a negative feedback cycle, and is also affected by parathyroid hormone, fibroblast ...
Fibroblast growth factor 23
... inhibition of production of calcitriol, stimulation of breakdown of calcitriol, and inhibition of production/secretion of ... FGF23 is secreted by osteocytes in response to increased calcitriol. FGF23 acts on the kidneys, where it decreases the ...
Bone resorption
Calcitriol (1,25-dihydroxycholecalciferol) is the active form of vitamin D3. It has numerous functions involved in blood ... Recent research indicates that calcitriol leads to a reduction in osteoclast formation, and bone resorption. It follows that an ... the precursor to calcitriol. Calcitonin is a hormone secreted by the thyroid in humans. Calcitonin decreases osteoclast ...
Brown tumor
Calcitriol (Rocaltrol) and cinacalcet (a calcimimetic) are used as pharmacologic treatments. Age and gender have an effect on ...
McCune-Albright syndrome
Oral phosphate and calcitriol may be given for treatment of hypophosphatemia. For growth hormone excess, treatment with ...
Ronyó - Viquipèdia, l'enciclopèdia lliure
La forma anàloga activa de la vitamina D (calcitriol),[13] que ajuda a mantenir el calci per als ossos i l'equilibri químic ... Lung, BE; Mowery, ML; Komatsu, DEE «Calcitriol» (en anglès). StatPearls [Internet]. StatPearls Publishing LLC, 2020 Jun 3; ...
Cyclooxygenase
Calcitriol (vitamin D) significantly inhibits the expression of the COX-2 gene. Caution should be exercised in combining low ...
Osteopontin
Synthesis of osteopontin is stimulated by calcitriol (1,25-dihydroxy-vitamin D3). Regulation of the osteopontin gene is ... Hypocalcemia and hypophosphatemia (instances that stimulate kidney proximal tubule cells to produce calcitriol (1α,25- ...
Kidney
Calcitriol, the activated form of vitamin D, promotes intestinal absorption of calcium and the renal reabsorption of phosphate ... For example, they convert a precursor of vitamin D to its active form, calcitriol; and synthesize the hormones erythropoietin ... The kidneys secrete a variety of hormones, including erythropoietin, calcitriol, and renin. Erythropoietin is released in ...
Renal physiology
Calcitriol, the activated form of vitamin D, promotes intestinal absorption of calcium and the renal reabsorption of phosphate ... The kidneys secrete a variety of hormones, including erythropoietin, calcitriol, and renin. Erythropoietin is released in ...
Immune system
... calcidiol into calcitriol. Only after binding to calcitriol can T-cells perform their intended function. Other immune system ... the steroid hormone calcitriol. T-cells have a symbiotic relationship with vitamin D. Not only does the T-cell extend a vitamin ... D receptor, in essence asking to bind to the steroid hormone version of vitamin D, calcitriol, but the T-cell expresses the ...
Parathyroid hormone
PTH is parathyroid hormone, 1,25 OH VIT D3 is calcitriol or 1,25 dihydroxyvitamin D3, and CALCITONIN is a hormone secreted by ... calcitriol), which is released into the circulation. This latter form of vitamin D is the active hormone which stimulates ...
Talk:Vitamin D/Archive 5
"Activated vitamin D (calcitriol) is a pluripotent pleiotropic secosteroid hormone. As a steroid hormone, which regulates more ... Recent research indicates that intracellular calcitriol levels in numerous human tissues, including nerve and muscle tissue, ... and calcitriol do not appear to be effective.[4] ... than 1000 vitamin D-responsive human genes, calcitriol may ...
Secondary hyperparathyroidism
... such as calcitriol, doxercalciferol, paricalcitol; and phosphate binders, which are either calcium-based and non-calcium based ...
Eldecalcitol
... calcitriol, performs its function through interactions with the calcitriol receptor. This nuclear hormone receptor is ... This greater affinity is 2.7-fold that of the active vitamin D form of calcitriol. Eldecalcitol is readily absorbed into the ... The chemistry of eldecalcitol allows for its binding 2.7-fold more potently than calcitriol. In addition, some vitamin D ... The eldecalcitol analog of calcitriol, contains a hydroxypropyl group in the lower cyclohexane ring. The synthesis of ...
Naive T cell
Hence the activation of naive T cells is crucially dependent on adequate calcitriol levels. In summary, activation of T cells ... However, activated TCR signaling through p38 upregulates VDR expression and calcitriol activated VDR, in turn, upregulates PLC- ... the expression of PLC-γ1 is dependent on VDR activated by calcitriol. Naive T cells have very low expression of VDR and PLC-γ1 ...
X-linked hypophosphatemia
It is also treated with medications including human growth hormone, calcitriol, and phosphate. The prevalence of the disease is ... Biochemically in blood, XLH is recognized by hypophosphatemia and an inappropriately low level of calcitriol (1,25-(OH)2 ... while calcitriol levels are low or within the lower reference range. Most importantly, urinary loss of phosphate is above the ... calcitriol; in the event of severe bowing, an osteotomy may be performed to correct the leg shape. The monoclonal antibody ...
Glutathione
Calcitriol (1,25-dihydroxyvitamin D3), the active metabolite of vitamin D3, after being synthesized from calcifediol in the ... About ten days are needed for the body to process vitamin D3 into calcitriol. S-adenosylmethionine (SAMe), a cosubstrate ...
Homeostasis
It stimulates the manufacture and release, by the kidneys, of calcitriol into the blood. This steroid hormone acts on the ...
Cholecalciferol
The action of calcitriol is mediated by the vitamin D receptor, a nuclear receptor which regulates the synthesis of hundreds of ... It is converted in the liver to calcifediol (25-hydroxyvitamin D) which is then converted in the kidney to calcitriol (1,25- ... Hydroxylation in the kidneys of calcifediol to calcitriol by 1-alpha-hydroxylase is tightly regulated: it is stimulated by ... 25-Hydroxyvitamin D3 1-alpha-Hydroxylase, a kidney enzyme that converts calcifediol to calcitriol. Coulston AM, Boushey C, ...
Hypercalcaemia
These plants contain calcitriol or similar substances that cause rises in calcium ion levels. Hypercalcemia is most common in ... see calcitriol under Vitamin D) levels (e.g. sarcoidosis and other granulomatous diseases such as tuberculosis, berylliosis, ...
Methamphetamine
It has been suggested, based on animal research, that calcitriol, the active metabolite of vitamin D, can provide significant ... Cass WA, Smith MP, Peters LE (2006). "Calcitriol protects against the dopamine- and serotonin-depleting effects of neurotoxic ...
Vitamin D toxicity
The levels of the active form of vitamin D, calcitriol, are inversely correlated with coronary calcification.[23] Moreover, the ... Intake of vitamin D raises the concentration of vitamin D metabolites which exceed DBP binding capacity and free calcitriol ... Intake of vitamin D raises calcitriol concentrations in the plasma and cell ...
Calbindin
Expression could be induced by treating these animals with vitamin D metabolites such as calcitriol. They were found to exist ... Expression of S100G, like that of calbindin 1, is stimulated by the active vitamin D metabolite, calcitriol although the ...
calcitriol (CHEBI:17823)
... has role vitamin (CHEBI:33229) calcitriol (CHEBI:17823) is a D3 vitamins (CHEBI:73558) calcitriol ( ... calcitriol 25-O-(β-D-glucuronate) (CHEBI:139274) has functional parent calcitriol (CHEBI:17823). calcitriol 25-O-(β-D- ... calcitriol (CHEBI:17823) has role hormone (CHEBI:24621) calcitriol (CHEBI:17823) has role human metabolite (CHEBI:77746) ... calcitriol (CHEBI:17823) has role metabolite (CHEBI:25212) calcitriol (CHEBI:17823) has role mouse metabolite (CHEBI:75771) ...
Calcitriol: MedlinePlus Drug Information
Calcitriol: learn about side effects, dosage, special precautions, and more on MedlinePlus ... If you become pregnant while taking calcitriol, call your doctor. You should not breastfeed while you are taking calcitriol. ... Calcitriol comes as a capsule and a solution (liquid) to take by mouth. It usually is taken once a day or once every other day ... Calcitriol will work only if you get the right amount of calcium from the foods you eat. If you get too much calcium from foods ...
Calcitriol Topical: MedlinePlus Drug Information
Calcitriol Topical: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Apply calcitriol ointment to the areas of skin affected by plaque psoriasis. Do not apply calcitriol ointment to healthy skin ... Before using calcitriol topical,. *tell your doctor and pharmacist if you are allergic to calcitriol, any other medications, or ... If you become pregnant while using calcitriol topcial, call your doctor. If you are breastfeeding while using calcitriol ...
Calcitriol - Wikipedia
Thus calcitriol also stimulates the intestinal absorption of phosphate. The observation that calcitriol stimulates the release ... PTH also stimulates the production of calcitriol (see below). Many of the effects of calcitriol are mediated by its interaction ... Calcitriol was identified as the active form of vitamin D in 1971 and the drug was approved for medical use in the United ... Calcitriol is produced in the cells of the proximal tubule of the nephron in the kidneys by the action of 25-hydroxyvitamin D3 ...
calcitriol (Rocaltrol) Uses, Side Effects & Dosage
Calcitriol (Rocaltrol) is prescribed to treat and prevent low levels of calcium in people with kidney disease or parathyroid ... How should I keep calcitriol stored?. Calcitriol should be stored at room temperature, between 15 C and 30 C (59 F and 86 F). ... calcitriol (Rocaltrol). *What is calcitriol, and how does it work (mechanism of action)? ... Higher doses of calcitriol may be necessary if these drugs are used together with calcitriol. ...
Calcitriol Purissimus - Drugs.com
A list of US medications equivalent to Calcitriol Purissimus is available on the Drugs.com website. ... Calcitriol Purissimus is a medicine available in a number of countries worldwide. ... Ingredient matches for Calcitriol Purissimus. Calcitriol. Calcitriol is reported as an ingredient of Calcitriol Purissimus in ... Calcitriol Purissimus. Calcitriol Purissimus may be available in the countries listed below. ...
Side Effects of Rocaltrol (calcitriol): Interactions & Warnings
... calcitriol) is a synthetic form of vitamin D3 used to treat and prevent low levels of calcium in the blood of patients with ... Side Effects of Rocaltrol (calcitriol). *Does Rocaltrol (calcitriol) cause side effects?. *What are the important side effects ... What are the important side effects of Rocaltrol (calcitriol)?. *Rocaltrol (calcitriol) side effects list for healthcare ... Ketoconazole may inhibit both synthetic and catabolic enzymes of calcitriol. *Reductions in serum endogenous calcitriol ...
DailyMed - CALCITRIOL ointment
Calcitriol Ointment Important: Calcitriol Ointment is for use on the skin only (topical use). Do not use Calcitriol Ointment in ... CALCITRIOL (UNII: FXC9231JVH) (CALCITRIOL - UNII:FXC9231JVH) CALCITRIOL. 3 ug in 1 g. ... Do not use Calcitriol Ointment for a condition for which it was not prescribed. Do not give Calcitriol Ointment to other people ... Calcitriol Ointment should not be applied to the eyes, lips, or facial skin.. Calcitriol Ointment is for topical use only. ...
DailyMed - CALCITRIOL capsule
Use of calcitriol in patients with known hypersensitivity to calcitriol (or drugs of the same class) or any of the inactive ... Calcitriol from ingested calcitriol capsules may be excreted in human milk. Because many drugs are excreted in human milk and ... If calcitriol therapy was previously administered at a dosage of 0.25 mcg/day, calcitriol therapy may be reinstituted at a ... Calcitriol is approximately 99.9% bound in blood. Calcitriol and other vitamin D metabolites are transported in blood, by an ...
Prescriber Checkup | CALCITRIOL
Buy Calcitriol 0.25mg on PureVolume
Download and stream Buy Calcitriol 0.25mg songs and albums, watch videos, see pictures, find tour dates, and keep up with all ... buy 0.25mg calcitriol. can buy calcitriol internet. buy calcitriol with a mastercard. how can you buy calcitriol. calcitriol ... calcitriol where to buy forums. calcitriol information calcitriol buy online. cheap calcitriol drug. cheap calcitriol men. ... Purchase Calcitriol 0.25 Mg Online Now. how to purchase calcitriol australia. buy calcitriol online england. calcitriol cheap ...
Calcitriol Dosage Guide with Precautions - Drugs.com
Detailed Calcitriol dosage information for adults and children. Includes dosages for Hypocalcemia, Hypoparathyroidism, ... Renal Osteodystrophy ergocalciferol, calcitriol, Vitamin D2, Drisdol, Rocaltrol, More.... Rickets ergocalciferol, calcitriol, ... Hypoparathyroidism ergocalciferol, calcitriol, Vitamin D2, Drisdol, Rocaltrol, More.... Hypocalcemia ergocalciferol, Caltrate, ... calcitriol, calcium carbonate, Vitamin D2, Drisdol, More.... ... More about calcitriol. *Side Effects. *During Pregnancy or ...
Calcitriol (Topical) | Memorial Sloan Kettering Cancer Center
calcitriol (vitamin D3) | Cigna
Calcitriol is used to treat hyperparathyroidism (overactive parathyroid glands) and metabolic bone disease in people who have ... Calcitriol is vitamin D3. Vitamin D is important for the absorption of calcium from the stomach and for the functioning of ... What is calcitriol?. Calcitriol is vitamin D3. Vitamin D is important for the absorption of calcium from the stomach and for ... Calcitriol 0.25 mcg-ROX. slide 1 of 4, Calcitriol 0.25 mcg-ROX, ... Calcitriol 0.25 mcg-TEV. slide 2 of 4, Calcitriol 0.25 mcg-TEV, ...
VECTICAL (calcitriol ointment) | Side Effects, Adverse Reactions | Healthgrades.com
Calcitriol - DrugBank
Calcitriol is also commonly used as a medication in the treatment of hypocalcemia and osteoporosis. ... Calcitriol is marketed under various trade names including Rocaltrol (Roche), Calcijex (Abbott) and Decostriol (Mibe, Jesalis ... Calcitriol or 1,25-dihydroxycholecalciferol (abbreviated 1,25-(OH)2-D3) is the active form of vitamin D found in the ... Calcitriol. ATC Codes. A11CC04 - Calcitriol*A11CC - Vitamin D and analogues. *A11C - VITAMIN A AND D, INCL. COMBINATIONS OF THE ...
Calcitriol in Advanced Intrahepatic Cholangiocarcinoma - Full Text View - ClinicalTrials.gov
Intervention Details: Drug: Calcitriol 12 mcg Calcitriol will be given orally three times per week for 6 months. In this ... Calcitriol in Advanced Intrahepatic Cholangiocarcinoma. The safety and scientific validity of this study is the responsibility ... Calcitriol. Fluorouracil. Mitomycins. Mitomycin. Micronutrients. Growth Substances. Physiological Effects of Drugs. Bone ... Drug Information available for: Calcitriol Genetic and Rare Diseases Information Center resources: Bile Duct Cancer ...
Calcitriol Side Effects
Evaluations from Patients who take Calcitriol topical | PatientsLikeMe
Will The Combination Of Calcitriol and Docetaxel Work ?
Calcitriol order no prescription, Calcitriol 0.25mg Without Script - Gravatar Profile
cheap calcitriol 0.25mg. buy calcitriol online boise. where to buy calcitriol calgary. calcitriol one buy online. calcitriol ... low dose calcitriol uk buy. buying calcitriol from mexico. generic calcitriol pills cheap. generic calcitriol buy calcitriol. ... calcitriol coupon codes 2015. calcitriol buy london. calcitriol generic where to buy online. calcitriol buy org. buy calcitriol ... can you buy calcitriol with calcitriol canada. purchase calcitriol edmonton. calcitriol original for sale cheap. calcitriol ...
Oral Calcitriol With Ketoconazole in CRPC - Full Text View - ClinicalTrials.gov
Drug: Calcitriol, Ketoconazole, Hydrocortisone Calcitriol (0.5 mcg caplets) given in escalating doses, orally QD X3 consecutive ... Experimental: Calcitriol, Ketoconazole, Hydrocortisone Patients receive calcitriol (10mcg QD X3 weekly) in addition to ... Pharmacokinetics of high-dose oral calcitriol: results from a phase 1 trial of calcitriol and paclitaxel. Clin Pharmacol Ther. ... Oral Calcitriol With Ketoconazole in CRPC. The safety and scientific validity of this study is the responsibility of the study ...
Calcitriol (On the skin) | University of Maryland Medical Center
Calcitriol (On the skin). Introduction. Calcitriol (kal-si-TRYE-ol). Treats psoriasis. This medicine is a form of vitamin D. ... Do not use more calcitriol than your doctor ordered. Too much of this medicine may cause a dangerous amount of calcium to build ... Some medicines can affect how calcitriol works. Tell your doctor if you are taking a diuretic (water pill), such as ... Do not take vitamins, calcium supplements, or other forms of vitamin D while you are taking calcitriol. ...
Calcitriol 1-mcg/mL Injection
A formulation for preparing Calcitriol 1-mcg/mL Injection. Includes ingredients, method of preparation, discussion, and ... Calcitriol 1-mcg/mL Injection. Allen Loyd V Jr Jul/Aug 2014. 324. Buy. ... Abstract: A formulation for preparing Calcitriol 1-mcg/mL Injection. Includes ingredients, method of preparation, discussion, ... Related Keywords: Loyd V. Allen, Jr., PhD, RPh, calcitriol, formulation, parenteral administration, compounded sterile ...
Calcitriol-Odan - Uses, Side Effects, Interactions - MedBroadcast.com
Calcitriol belongs to the group of medications called vitamin D3 metabolites. Calcitriol is a form of vitamin D that is active ... Do not use calcitriol if you:. *are allergic to calcitriol, vitamin D or forms of vitamin D, or any ingredients of the ... Calcitriol belongs to the group of medications called vitamin D3 metabolites. Calcitriol is a form of vitamin D that is active ... 02431637 Calcitriol-Odan 0.25ug capsule. 02431645 Calcitriol-Odan 0.5ug capsule. ...
StateMaster - Encyclopedia: Calcitriol
Calcitriol (1148 words). Calcitriol and 1,25 dihydroxycholecalciferol are both scientific names for active vitamin D. The ... The active form of the vitamin is calcitriol which is synthesized from either D2 or D3 in the kidneys. Calcitriol binds to a ... Encyclopedia , Calcitriol. Vitamin D is a fat soluble vitamin that contributes to the maintenance of normal levels of calcium ... Calcitriol - Wikipedia, the free encyclopedia (211 words). It is produced in the kidneys by conversion from 25- ...
Calcitriol (GenRx) | healthdirect
On this page about Calcitriol (GenRx) you will find information relating to side effects, age restrictions, food interactions, ... Other medicines containing the same active ingredients: calcitriol *Can I take Calcitriol (GenRx) in sport? Find out on the ... APO-Calcitriol is indicated for the:,- treatment of established osteoporosis diagnosed by objective measuring techniques, such ... For the active ingredient calcitriol. You should seek advice from your doctor or pharmacist about taking this medicine. They ...
Calcitriol in the Treatment of Immunoglobulin A Nephropathy - Full Text View - ClinicalTrials.gov
Calcitriol in the Treatment of Immunoglobulin A Nephropathy. The safety and scientific validity of this study is the ... Calcitriol. Immunologic Factors. Physiological Effects of Drugs. Calcium Channel Agonists. Membrane Transport Modulators. ... Drug Information available for: Calcitriol Genetic and Rare Diseases Information Center resources: IgA Nephropathy ... This study will explore the potential anti-proteinuric and anti-inflammatory effects of Calcitriol in the treatment of IgA ...
Immunointervention With Calcitriol in New-Onset Type 1 Diabetes - Tabular View - ClinicalTrials.gov
Calcitriol injection - AHealthyMe - Blue Cross Blue Shield of Massachusetts
RocaltrolEffect of calcitriolForm of vitaminEffects of calcitriolOintmentCalciumHypercalcemiaCapsuleAbsorptionStudy of calcitriolDoses of calcitriolProduction of calcitriolAdministration of calcitriolBoneSupplementationDose calcitriolDiscount calcitriolDialysisMaximum tolerated dose of calcitriolOsteoporosisTreatment of secondary hyperparathyroidism in chronicDosageMedicationOralPatientsTopicalInhibitionHyperparathyroidismCombined phosphateElevated calcitriol levelsInhibitsPrescription buying calReceptorAnalogsInteract with calcitriolCombination Of CalcitriolKidneyVitamin D metaboliteParathyroid hormone levelsDifferentiationMedicationsConcentrationsRicketsCapsulesTake calcitriolHigh calcitriolOrder calcitriolGlobal CalcitriolCalcijexSerum PTH levelsEfficacy
Rocaltrol12
- Calcitriol (Rocaltrol, Calcijex is a discontinued brand) is a medication prescribed to treat low levels of calcium in people with kidney disease, rickets, and familial hypophosphatemia. (medicinenet.com)
- Does Rocaltrol (calcitriol) cause side effects? (medicinenet.com)
- Rocaltrol ( calcitriol ) is a synthetic active form of vitamin D3 ( cholecalciferol ) used to treat and prevent low levels of calcium in the blood of patients who have kidney disease or problems with their parathyroid gland, the gland that controls the amount of calcium in blood through its secretion of parathyroid hormone. (medicinenet.com)
- Calcitriol is marketed under various trade names including Rocaltrol (Roche), Calcijex (Abbott) and Decostriol (Mibe, Jesalis). (drugbank.ca)
- What is calcitriol (Rocaltrol)? (emedicinehealth.com)
- What is the most important information I should know about calcitriol (Rocaltrol)? (emedicinehealth.com)
- What should I discuss with my healthcare provider before taking calcitriol (Rocaltrol)? (emedicinehealth.com)
- Calcitriol yw cynhwysyn actif Rocaltrol a Vectical. (wikipedia.org)
- Calcitriol (Brand names: Vectical, Rocaltrol) is prescribed for the treatment of low calcium and psoriasis. (pharmacychecker.com)
- Calcitriol(Rocaltrol) generic Alfa D3 (1 mcg) is a synthetic vitamin D analog, prescribed for hypocalcemia in patients undergoing chronic renal dialysis. (medindia.net)
- Rocaltrol, also known as Calcitriol, is a medication used to treat conditions that are caused as a result of high or low parathyroid hormone levels. (rpspharmacy.com)
- Rocaltrol (Calcitriol) is a form of vitamin D, necessary for normal bone development. (buyviagrapharmacy.com)
Effect of calcitriol4
- The beneficial effect of calcitriol in renal osteodystrophy appears to result from correction of hypocalcemia and secondary hyperparathyroidism. (nih.gov)
- In this study, we selected this approach to test several hypotheses about the effect of calcitriol (1,25-dihydroxycholecalciferol), the active form of vitamin D, on early-stage human prostate cancer. (aacrjournals.org)
- Secondary objective was to evaluate the effect of calcitriol on migration and invasion of OS cell lines, and the role of matrix metalloproteins (MMPs) in migration/invasion. (ku.edu)
- We examined the effect of calcitriol versus cholecalciferol supplementation on vascular endothelial function in patients with CKD. (asnjournals.org)
Form of vitamin19
- It is the active form of vitamin D 3 , produced fom calciol via hydoxylation in the liver to form calcidiol, which is subsequently oxidised in the kidney to give calcitriol. (ebi.ac.uk)
- Calcitriol is a synthetic (man-made) active form of vitamin D3 ( cholecalciferol ). (medicinenet.com)
- Calcitriol is the most active known form of vitamin D 3 in stimulating intestinal calcium transport. (nih.gov)
- Calcitriol is the active form of vitamin D, normally made in the kidney. (wikipedia.org)
- Calcitriol was identified as the active form of vitamin D in 1971 and the drug was approved for medical use in the United States in 1978. (wikipedia.org)
- Calcitriol or 1,25-dihydroxycholecalciferol (abbreviated 1,25-(OH) 2 -D3) is the active form of vitamin D found in the body (vitamin D3). (drugbank.ca)
- Researchers from Canada, United States and Europe are registering men with advanced prostate cancer for a study involving a treatment that combines chemotherapy with high-dose of Calcitriol, a naturally occurring active form of vitamin D. (medindia.net)
- Calcitriol is a form of vitamin D that is active in the body. (medbroadcast.com)
- CALCITRIOL (kal si TRYE ole) is a man-made form of vitamin D. It is used to treat patients with low levels of calcium who are on chronic renal dialysis. (ahealthyme.com)
- We show that calcitriol, the hormonally active form of vitamin D, regulates the expression of aromatase in a tissue-selective manner. (nih.gov)
- OBJECTIVE We investigated whether supplementation of the active form of vitamin D (calcitriol) in recent-onset type 1 diabetes can protect β-cell function evaluated by C-peptide and improve glycemic control assessed by A1C and insulin requirement. (diabetesjournals.org)
- The aim of this pilot trial was to investigate whether the supplementation of the active form of vitamin D (calcitriol) in subjects with recent-onset type 1 diabetes is able to protect residual β-cell function (C-peptide) and to improve metabolic control. (diabetesjournals.org)
- A double-blind trial was designed with patients randomized to 0.25 μg/daily calcitriol (the active form of vitamin D, 1.25-dihydroxyvitamin D3) or placebo and followed-up for 2 years. (diabetesjournals.org)
- CALCITRIOL (kal si TRYE ole) is a man made form of vitamin D. It is used on the skin to treat plaque psoriasis. (brighamandwomens.org)
- CALCITRIOL (kal si TRYE ole) is a man made form of vitamin D. It helps your body keep the proper levels of calcium and phosphorus and maintain healthy bones and teeth. (aarpmedicareplans.com)
- A team led by Michel Vallée, MD, PhD, of Maisonneuve-Rosemont Hospital, University of Montreal, studied a retrospective cohort of 45 chronic HD patients with SHPT who were switched from oral alfacaclidol-which requires 25-hydoxylation in the liver to be effective-to oral calcitriol -the fully hydoxylated active form of vitamin D3. (renalandurologynews.com)
- also know as calcitriol), the hormonal form of vitamin D, can inhibit the proliferation and promote the differentiation of human prostate adenocarcinoma cells. (aacrjournals.org)
- Due to the hypercalcemic side effects of vitamin D and its derivatives in higher plasma concentrations, the anti-cancer benefits of calcitriol (the active form of vitamin D) have not been fully realized in prostate cancer (PCa) chemoprevention and/or treatment. (urotoday.com)
- COX-2 is naturally inhibited by calcitriol (the active form of Vitamin D). Both the peroxidase and PTGS activities are inactivated during catalysis by mechanism-based, first-order processes, which means that PGHS-2 peroxidase or PTGS activities fall to zero within 1-2 minutes, even in the presence of sufficient substrates. (wikipedia.org)
Effects of calcitriol8
- If you get too much calcium from foods, you may experience serious side effects of calcitriol, and if you do not get enough calcium from foods, calcitriol will not control your condition. (medlineplus.gov)
- What are the side effects of calcitriol? (medicinenet.com)
- The effects of Calcitriol Ointment on calcium metabolism following treatment durations greater than 52 weeks have not been evaluated. (nih.gov)
- Many of the effects of calcitriol are mediated by its interaction with the calcitriol receptor, also called the vitamin D receptor or VDR. (wikipedia.org)
- This study will explore the potential anti-proteinuric and anti-inflammatory effects of Calcitriol in the treatment of IgA nephropathy, which has no specific treatment at present. (clinicaltrials.gov)
- Hypercalcemia and hypercalciuria, the most common side effects of calcitriol therapy, were not documented in the trials reviewed, and might have been the result of the low dosages used. (dovepress.com)
- 1 yr) effects of calcitriol replacement treatment have not been reported. (biomedsearch.com)
- Objective: Our primary objective is to investigate effects of calcitriol in combination with cisplatin on the osteosarcoma cell apoptosis, invasion and migration. (ku.edu)
Ointment35
- Calcitriol comes as an ointment to apply to the skin. (medlineplus.gov)
- Apply calcitriol ointment at around the same times every day. (medlineplus.gov)
- Apply calcitriol ointment exactly as directed. (medlineplus.gov)
- In children 2 to 6 years of age, do not use more than one tube (100 gm) of calcitriol ointment per week. (medlineplus.gov)
- In adults and children 7 years of age and older, do not use more than two tubes (200 gm) of calcitriol ointment per week. (medlineplus.gov)
- Apply calcitriol ointment to the areas of skin affected by plaque psoriasis. (medlineplus.gov)
- Do not apply calcitriol ointment to healthy skin or anywhere on your face, eyes, lips, or vagina. (medlineplus.gov)
- Do not cover the skin where you applied calcitriol ointment with a bandage or dressing unless your doctor tells you that you should. (medlineplus.gov)
- Wash your hands well with soap and water after you apply calcitriol ointment. (medlineplus.gov)
- Do not freeze or refrigerate calcitriol ointment. (medlineplus.gov)
- These highlights do not include all the information needed to use Calcitriol Ointment safely and effectively. (nih.gov)
- See full prescribing information for Calcitriol Ointment. (nih.gov)
- The safety and effectiveness of Calcitriol Ointment in patients with known or suspected disorders of calcium metabolism have not been evaluated. (nih.gov)
- Apply Calcitriol Ointment to affected areas of the body twice daily ( 2 ). (nih.gov)
- If aberrations in parameters of calcium metabolism are noted discontinue Calcitriol Ointment until these normalize. (nih.gov)
- Apply Calcitriol Ointment to affected areas twice daily, morning and evening. (nih.gov)
- Calcitriol Ointment should not be applied to the eyes, lips, or facial skin. (nih.gov)
- Calcitriol Ointment is not for oral, ophthalmic or intravaginal use. (nih.gov)
- Each gram of Calcitriol Ointment contains 3 micrograms (mcg/g) of calcitriol. (nih.gov)
- In controlled clinical trials hypercalcemia was observed in subjects exposed to Calcitriol Ointment. (nih.gov)
- Calcitriol is prescribed for: Treatment of hypocalcaemia - hypoparathyroidism, osteomalacia (adults), rickets (infants, children), renal osteodystrophy, chronic kidney disease Treatment of osteoporosis Prevention of corticosteroid-induced osteoporosis Calcitriol has been used in an ointment for the treatment of psoriasis, although the vitamin D analogue calcipotriol (calcipotriene) is more commonly used. (wikipedia.org)
- Calcitriol Ointment is a vitamin D analog. (drugster.info)
- Some medical conditions may interact with Calcitriol Ointment. (drugster.info)
- Ask your health care provider if Calcitriol Ointment may interact with other medicines that you take. (drugster.info)
- Use Calcitriol Ointment as directed by your doctor. (drugster.info)
- Apply a thin layer of Calcitriol Ointment and gently rub it into the skin until it is absorbed. (drugster.info)
- Wash your hands immediately after using Calcitriol Ointment unless your hands are part of the treated area. (drugster.info)
- Calcitriol Ointment is for use on the skin only. (drugster.info)
- If you miss a dose of Calcitriol Ointment, use it as soon as possible. (drugster.info)
- Ask your health care provider any questions you may have about how to use Calcitriol Ointment. (drugster.info)
- Calcitriol Ointment may cause you to become sunburned more easily. (drugster.info)
- Avoid the sun, sunlamps, or tanning booths while using Calcitriol Ointment. (drugster.info)
- You will need to discuss the benefits and risks of using Calcitriol Ointment while you are pregnant. (drugster.info)
- It is not known if Calcitriol Ointment is found in breast milk. (drugster.info)
- If you are or will be breast-feeding while you use Calcitriol Ointment, check with your doctor. (drugster.info)
Calcium33
- Calcitriol is used to treat and prevent low levels of calcium and bone disease in patients whose kidneys or parathyroid glands (glands in the neck that release natural substances to control the amount of calcium in the blood) are not working normally. (medlineplus.gov)
- Calcitriol is also sometimes used to increase the amount of calcium in the blood of premature babies. (medlineplus.gov)
- Calcitriol will work only if you get the right amount of calcium from the foods you eat. (medlineplus.gov)
- Calcitriol increases blood levels of calcium by increasing the absorption of calcium in the kidneys, increasing the absorption of calcium and phosphorus from the intestine, and increasing the release of calcium and phosphorus from the bones. (medicinenet.com)
- Calcitriol helps the body to use calcium found in foods and supplements . (medicinenet.com)
- Since calcitriol also increases calcium levels, taking these two types of medications together may cause hypercalcemia (abnormally highly levels of calcium). (medicinenet.com)
- Because of the short biological half-life of calcitriol, pharmacokinetic investigations have shown normalization of elevated serum calcium within a few days of treatment withdrawal, i.e., much faster than in treatment with vitamin D 3 preparations. (medicinenet.com)
- Calcitriol is a synthetic vitamin D analog which is active in the regulation of the absorption of calcium from the gastrointestinal tract and its utilization in the body. (nih.gov)
- In acutely uremic rats calcitriol has been shown to stimulate intestinal calcium absorption. (nih.gov)
- Calcitriol increases blood calcium (Ca2+) mainly by increasing the uptake of calcium from the intestines. (wikipedia.org)
- mycobacterium avium, leprosy, lipoid pneumonia, cat scratch fever, berylliosis Calcitriol increases blood calcium levels ([Ca2+ ]) by: Promoting absorption of dietary calcium from the gastrointestinal tract. (wikipedia.org)
- When calcitriol binds to the receptor, the ligand-receptor complex translocates to the cell nucleus, where it acts as a transcription factor promoting the expression of a gene encoding a calcium binding protein. (wikipedia.org)
- You should not use this medication if you have high levels of calcium or vitamin D in your blood, or if you have ever had an allergic reaction to calcitriol or other forms of vitamin D. (cigna.com)
- Calcitriol is also used to treat calcium deficiency (hypocalcemia) and metabolic bone disease in people who are receiving dialysis. (cigna.com)
- Calcitriol is also used to treat calcium deficiency in people with hypoparathyroidism (underactive parathyroid glands) caused by surgery, disease, or other conditions. (cigna.com)
- Do not take vitamins, calcium supplements, or other forms of vitamin D while you are taking calcitriol. (umm.edu)
- Calcitriol is used to help increase the amount of calcium in the blood and help with proper bone formation for people with chronic kidney failure that are undergoing dialysis. (medbroadcast.com)
- We studied whether corticosteroid-induced osteoporosis could be prevented by treatment with calcium, calcitriol (1,25-dihydroxyvitamin D3), and calcitonin. (nih.gov)
- One hundred three patients starting long-term corticosteroid therapy were randomly assigned to receive 1000 mg of calcium per day orally and either calcitriol (0.5 to 1.0 microgram per day orally) plus salmon calcitonin (400 IU per day intranasally), calcitriol plus a placebo nasal spray, or double placebo for one year. (nih.gov)
- Calcitriol (mean dose, 0.6 microgram per day), with or without calcitonin, prevented more bone loss from the lumbar spine (mean rates of change, -0.2 and -1.3 percent per year, respectively) than calcium alone (-4.3 percent per year, P = 0.0035). (nih.gov)
- In the second year, lumbar bone loss did not occur in the group previously treated with calcitonin plus calcitriol (+0.7 percent per year), but it did occur in the group given calcium alone (-2.3 percent per year). (nih.gov)
- Calcitriol and calcium, used prophylactically with or without calcitonin, prevent corticosteroid-induced bone loss in the lumbar spine. (nih.gov)
- Calcitriol increases intestinal absorption of calcium and phosphorus, and in concert with parathyroid hormone increases bone resorption. (hmdb.ca)
- Bypassing hepatic 25-hydroxylation appears to be associated with greater efficacy of calcitriol at increasing serum calcium and inhibiting PTH secretion, the investigators concluded. (renalandurologynews.com)
- The decreases in vascular calcium content were associated with an increase in vascular Mg. Calcitriol treatment alone significantly decreased TRPM7 protein whereas the combination treatment increased both the mRNA and protein expression. (aspetjournals.org)
- Calcitriol, a calcitrophic hormone that can be suppressed by high dietary calcium, favors fatty acid synthesis and inhibits lipolysis via non-genomic modulation of Ca 2 + influx. (encognitive.com)
- 1.5 were randomly allocated to an E group (each cycle = oral etidronate 400 mg daily for 14 days followed by calcium 500 mg daily for 76 days) or an E+C group (as for E plus oral calcitriol 0.5 μg daily). (bmj.com)
- There is also some evidence that calcitriol (1,25-dihydroxyvitamin D 3 ), a vitamin D analogue, may reduce vertebral fracture rates, 4 and a combination of vitamin D 3 and calcium supplements can reduce the risk of hip fractures and increase hip BMD in elderly women. (bmj.com)
- Phosphate includes about one% of total Calcitriol entire body body weight, about eighty five% resides in bone, fourteen% in cells, and one% in serum and ECFs.12-14,86 Calcitriol Upkeep of serum phosphate inside of usual boundaries lets an optimum calcium-phosphate item for bone mineralization devoid of deposition in smooth tissues. (wallinside.com)
- Renal production of calcitriol is stimulated by PTH, low calcium and low phosphate and it is reduced by high phosphate and FGF23. (vitamindwiki.com)
- In CKD stage, 3-4 moderate doses of calcitriol are effective to control secondary hyperparathyroidism and observational studies suggest that calcitriol therapy increases survival and slows the progression of renal disease as long as phosphate and calcium levels are controlled. (vitamindwiki.com)
- Calcium and calcitriol therapy in osteoporotic postmenopausal women with impaired calcium absorption. (semanticscholar.org)
- The effects of oral calcitriol (0.25 and 0.50 micrograms/d), together with calcium (1 g/d), on calcium absorption and bone resorption were measured in postmenopausal osteoporotic women with calcium malabsorption. (semanticscholar.org)
Hypercalcemia7
- Hypercalcemia has been reported in patients treated with calcitriol. (medicinenet.com)
- Compared to other vitamin D compounds in clinical use (cholecalciferol, ergocalciferol), calcitriol has a higher risk of inducing hypercalcemia. (wikipedia.org)
- We have recently studied the case of a patient with Hodgkin's disease with hypercalcemia and increased calcitriol levels. (annals.org)
- Antineoplastic activity of calcitriol in preclinical systems is seen at concentrations significantly above the physiologic range, typically above 1 nmol/L. Such concentrations cannot be reached with conventional daily dosing of calcitriol due to predictable hypercalcemia and hypercalcuria ( 15 ). (aacrjournals.org)
- Incident calcitriol users and nonusers were selected on the basis of stages 3 to 4 CKD, hyperparathyroidism, and the absence of hypercalcemia before calcitriol use and then were matched by age and estimated kidney function. (asnjournals.org)
- Calcitriol use was associated with a greater risk for hypercalcemia. (asnjournals.org)
- In dialysis patients, the administration of calcitriol reduces serum PTH levels but it is also known that high doses of calcitriol are associated with hypercalcemia and worse control of hyperphosphatemia. (vitamindwiki.com)
Capsule3
- Calcitriol comes as a capsule and a solution (liquid) to take by mouth. (medlineplus.gov)
- Each orange, opaque, oval, soft gelatin capsule with "O25" printed in black contains 0.25 µg of calcitriol. (medbroadcast.com)
- Each orangeish-to-red, opaque, oval, soft gelatin capsule with "O50" printed in black contains 0.50 µg of calcitriol. (medbroadcast.com)
Absorption2
- Cholestyramine ( Questran ), colestipol ( Colestid ), mineral oil, and orlistat ( Alli , Xenical ) may decrease the intestinal absorption of calcitriol. (medicinenet.com)
- Classically, there are four principal acknowledged regulators of phosphate metabolism: (one) nutritional phosphate ingestion and absorption, (two) calcitriol, which can boost phosphorus resorption from bone and absorption from intestine, (three) PTH, which straight leads to phosphorus resorption from bone, and indirectly activates intestinal absorption by way of stimulation of calcitriol output, and (4) renal tubular reabsorption of phosphorus that is stimulated by tubular filtered load of phosphorus and inhibited by PTH. (wallinside.com)
Study of calcitriol3
- OUTLINE: This is a dose-limiting toxicity study of calcitriol. (clinicaltrials.gov)
- OUTLINE: This is a dose-escalation study of calcitriol. (knowcancer.com)
- Methodology/Principal Findings: We conducted a post-hoc analysis of a double-blind, placebo-controlled study of calcitriol supplementation to preserve β-cell function. (ebscohost.com)
Doses of calcitriol3
- Higher doses of calcitriol may be necessary if these drugs are used together with calcitriol. (medicinenet.com)
- Cohorts of 3-6 patients receive escalating doses of calcitriol until the maximum tolerated dose (MTD) is determined. (knowcancer.com)
- Our testing protocol left one week between pulse doses of Calcitriol while taking VitD daily. (thisisms.com)
Production of calcitriol2
- PTH also stimulates the production of calcitriol (see below). (wikipedia.org)
- We have studied whether or not the development of rachitic lesions in piglets with PVDRI is due to altered binding properties of the intestinal calcitriol receptor in addition to the defective renal production of calcitriol. (portlandpress.com)
Administration of calcitriol3
- Determine the effect of administration of calcitriol on the pharmacokinetics of paclitaxel in these patients. (knowcancer.com)
- CONCLUSIONS: Parathyroid adenoma injection is an alternative method of treatment for some patients resistant to treatment by means of vitamin D3 pulses or intravenous administration of calcitriol. (biomedsearch.com)
- In kidney transplant patients, the administration of calcitriol, 0.5 µg/48h prevents bone mass loss during the first few months after transplantation. (vitamindwiki.com)
Bone17
- The two known sites of action of calcitriol are intestine and bone. (nih.gov)
- The kidneys of uremic patients cannot adequately synthesize calcitriol, the active hormone formed from precursor vitamin D. Resultant hypocalcemia and secondary hyperparathyroidism are a major cause of the metabolic bone disease of renal failure. (nih.gov)
- Calcitriol is used to treat hyperparathyroidism (overactive parathyroid glands) and metabolic bone disease in people who have chronic kidney failure and are not receiving dialysis. (cigna.com)
- Calcitriol may also be used to treat vitamin D-resistant rickets, a bone disease caused by too little vitamin D. (medbroadcast.com)
- Evidence from these trials shows that calcitriol monotherapy can improve bone mineral density in elderly osteoporotic Chinese patients but may be insufficient for long-term treatment. (dovepress.com)
- Calcitriol can also decrease bone turnover markers and bring about significant improvements in muscle strength. (dovepress.com)
- Further, calcitriol in combination with other therapeutic bone agents was shown to be well tolerated and capable of additional bone-preserving effects compared with use of calcitriol alone in areas including bone mineral density, bone turnover markers, bone pain improvement, and fracture incidence. (dovepress.com)
- Calcitriol significantly decreased aromatase expression in human BCa cells and adipocytes and caused substantial increases in human osteosarcoma cells (a bone cell model exhibiting osteoblast phenotype in culture) and modest increases in ovarian cancer cells. (nih.gov)
- In addition to augmenting the ability of AIs to inhibit BCa growth, calcitriol acting as a selective aromatase modulator that increases aromatase expression in bone would reduce the estrogen deprivation in bone caused by the AIs, thus ameliorating the AI-induced side effect of osteoporosis. (nih.gov)
- The calcitriol group also lost lumbar bone (-3.6 percent per year) but received more corticosteroid in the second year than the other two groups. (nih.gov)
- The mRNA expressions of alkaline phosphatase (ALP), bone sialoprotein (BSP), core-binding factor alpha-1 (CBFA1), collagen-1 (Col-1), osteocalcin (OCN), and vitamin D 3 receptor (VDR) were assessed after incubation with calcitriol for 2 weeks. (hindawi.com)
- Treatment with calcitriol resulted in the normalization of biochemical parameters and mean lumbar spine areal bone mineral density z-scores within 3 months, whereas height z-scores increased more gradually. (biomedsearch.com)
- We investigated the effect of supplementation with calcitriol on bone turnover in recent-onset type 1 diabetes (T1D). (ebscohost.com)
- Changes in bone formation (osteoclacin) and resorption (beta-CrossLaps) markers, and differences between placebo and calcitriol-treated group were evaluated. (ebscohost.com)
- The aim of this study was to compare the effects of intermittent cyclical etidronate (E) therapy alone with a combination of cyclical etidronate and calcitriol (E+C) on spine and femoral neck bone mineral density (BMD) at one year. (bmj.com)
- In a retrospective study, we have assessed the efficacy of oral calcitriol on the evolution of hyperparathyroid bone disease in patients on hemodialysis. (ox.ac.uk)
- At the bone level calcitriol suppresses pre-osteoblasts and activates mature osteoblasts. (vitamindwiki.com)
Supplementation4
- High calcitriol levels may also be seen in human disease states in patients not on supplementation. (wikipedia.org)
- In this report, we present a girl with severe AD who under adequate supplementation with cholecalciferol was treated with calcitriol and subsequently with paricalcitol. (hindawi.com)
- We aimed to investigate effects of vitamin D supplementation on IGF-1 (primary outcome) and calcitriol (1,25(OH) 2 D) concentrations (secondary outcome). (mdpi.com)
- To assess the impact of calcitriol and phosphate supplementation on growth we analysed from a cohort of 18 patients treated at the Dept. of Paediatrics at O.-v.-Guericke-University Magdeburg. (nih.gov)
Dose calcitriol2
- Conclusions: High-dose calcitriol down-regulates VDR expression in human prostate cancer. (aacrjournals.org)
- Are any trials upcoming for high dose calcitriol? (thisisms.com)
Discount calcitriol1
- how to purchase calcitriol australia buy calcitriol online england calcitriol cheap buy buy pill buy calcitriol online chicago buy calcitriol legal canada no prescription where can i buy calcitriol or calcitriol where to buy real calcitriol uk buy discount calcitriol online generic no prescription Time to take your loved one out for a night of sushi! (purevolume.com)
Dialysis9
- Magnesium containing medications (for example, antacids) should be avoided in patients undergoing chronic renal dialysis who are taking calcitriol. (medicinenet.com)
- Local calcitriol injections as a suppressive treatment of secondary hyperparathyroidism in chronic dialysis patients. (biomedsearch.com)
- AIM: A prospective study was made of the effectiveness of repeatable local calcitriol injections therapy to suppress secondary hyperparathyroidism resistant to conventional therapy in chronic dialysis patients. (biomedsearch.com)
- DENVER-Oral paricalcitol (OP) appears to have similar efficacy and safety compared with oral calcitriol (OC) in dialysis patients with secondary hyperparathyroidism (SHPT) , according to results from a randomized, controlled trial. (renalandurologynews.com)
- We evaluated associations of oral calcitriol use with mortality and dialysis dependence in 1418 nondialysis patients with CKD and hyperparathyroidism in the Veterans' Affairs Consumer Health Information and Performance Sets database. (asnjournals.org)
- 18 - 21 Given biologic plausibility for an effect of oral calcitriol on survival and lack of clinical outcome data pertaining to this commonly prescribed CKD medication, we evaluated associations of oral calcitriol use with mortality and dialysis dependence in 1418 patients with stages 3 to 4 CKD and hyperparathyroidism. (asnjournals.org)
- During follow-up, 75 calcitriol users and 142 nonusers initiated long-term dialysis (10.4 events per 100 person-years and 10.1 events per 100 person years among calcitriol users and nonusers, respectively). (asnjournals.org)
- Cumulative incidence rates of mortality and mortality plus dialysis dependence remained lower among calcitriol users compared with nonusers throughout follow-up ( Figure 1 ). (asnjournals.org)
- 5. It was concluded that in addition to 1,25-dihydroxyvitamin D 3 deficiency, secondary hyperparathyroidism may participate in the abnormal lipid metabolism, glucose tolerance and insulin secretion seen in dialysis patients and these abnormalities could be, at least in part, improved by intravenous calcitriol treatment. (portlandpress.com)
Maximum tolerated dose of calcitriol2
- Determine the maximum tolerated dose of calcitriol administered with zoledronate in patients with progressive prostate cancer. (knowcancer.com)
- Determine the toxic effects and maximum tolerated dose of calcitriol when combined with paclitaxel in patients with advanced solid tumors. (knowcancer.com)
Osteoporosis5
- Calcitriol is also commonly used as a medication in the treatment of hypocalcemia and osteoporosis. (drugbank.ca)
- APO-Calcitriol is indicated for the:,- treatment of established osteoporosis diagnosed by objective measuring techniques, such as densitometry, or by radiographic evidence of a traumatic fracture . (healthdirect.gov.au)
- In a double-blind, randomized, placebo-controlled 2-year clinical trial reported in a recent issue, Ott and Chesnut (1) concluded that "calcitriol treatment is not effective in postmenopausal osteoporosis. (annals.org)
- Gallagher J, Riggs B. Calcitriol for Postmenopausal Osteoporosis. (annals.org)
- One study showed that treatment with calcitriol can improve quality of life in patients with osteoporosis, although not to the same extent as bisphosphonates. (dovepress.com)
Treatment of secondary hyperparathyroidism in chronic1
- Conversion of oral alfacalcidol to oral calcitriol in the treatment of secondary hyperparathyroidism in chronic hemodialysis patients. (renalandurologynews.com)
Dosage2
- What is the dosage for calcitriol? (medicinenet.com)
- The dosage form available for Benazepril/Calcitriol/Famotidine is Oral Oil Suspension. (wedgewoodpharmacy.com)
Medication1
- Calcitriol may also be used for purposes not listed in this medication guide. (cigna.com)
Oral9
- Peak serum concentrations (above basal values) were reached within 3 to 6 hours following oral administration of single doses of 0.25 to 1.0 mcg of calcitriol. (nih.gov)
- This study will aim to describe objective tumor responses to the combination of oral calcitriol and ketoconazole and hydrocortisone-among patients with measurable disease using modified RECIST 1.1 criteria. (clinicaltrials.gov)
- Additionally, we will determine toxicities, and tolerability of oral calcitriol combination with daily oral ketoconazole, and hydrocortisone in this patient population. (clinicaltrials.gov)
- Patients receive oral calcitriol weekly for 3 consecutive days and zoledronate IV monthly. (knowcancer.com)
- During course 1, patients receive oral calcitriol daily on days 1-3 of weeks 1-6 and paclitaxel IV over 1 hour on day 1 of week 1 and day 3 of weeks 2-6. (knowcancer.com)
- 1 strength combination of Benazepril/Calcitriol/Famotidine Oral Oil Suspension is available. (wedgewoodpharmacy.com)
- In conclusion, oral calcitriol use is associated with lower mortality in nondialysis patients with CKD. (asnjournals.org)
- 2 , 7 , 8 In clinical trials of predialysis patients with CKD, oral calcitriol or its analogues lowered serum PTH levels. (asnjournals.org)
- Participants were randomly assigned to oral cholecalciferol (2000 IU daily) or calcitriol (0.5 μ g) daily for 6 months. (asnjournals.org)
Patients25
- Calcitriol should be used cautiously in patients taking digoxin ( Lanoxin ). (medicinenet.com)
- The current study is set up a clinical trial phase II of vitamin D (calcitriol) in combination with 5-fluorouracil, Mitomycin C and Leucovorin in an open label-non-randomized study to evaluate the tumor response in patients with advanced intrahepatic cholangiocarcinoma. (clinicaltrials.gov)
- However there is one patient who responses to calcitriol and 5-fluorouracil/mitomycin C/leucovorin, the new 14 patients will be accrued during the secondary phase of study. (clinicaltrials.gov)
- In this portion of the study, all patients will get the same dose of calcitriol along with the standard chemotherapy (5-fluorouracil-mitomycin C-leucovorin). (clinicaltrials.gov)
- To assess quality of life (QOL) of patients who are received calcitriol in combination with 5-fluorouracil/mitomycin C/leucovorin. (clinicaltrials.gov)
- To assess the response of calcitriol in combination with 5-fluorouracil/mitomycin C/leucovorin in patients with advanced intrahepatic cholangiocarcinoma. (clinicaltrials.gov)
- Patients receive calcitriol (10mcg QD X3 weekly) in addition to ketoconazole (400mg QD) and hydrocortisone (20mg AM, 10 mg PM). (clinicaltrials.gov)
- Calcitriol therapy may be considered as a safe and efficacious treatment option for patients with severe AD, particularly for those with refractory AD, under monitoring for possible side effects. (hindawi.com)
- The number of patients to be included in the trial was calculated from setting a difference in basal C-peptide of 0.12 nmol/l at 2 years after diagnosis between the calcitriol and placebo groups. (diabetesjournals.org)
- Methods: After selection of surgical treatment for histologically confirmed adenocarcinoma of the prostate, patients were randomized to either calcitriol 0.5 μg/kg or placebo weekly for 4 weeks. (aacrjournals.org)
- Calcitriol may be the optimal active vitamin D3 therapy for hemodialysis (HD) patients with secondary hyperparathyroidism (SHPT) , according to researchers. (renalandurologynews.com)
- In light of these results, calcitriol may be the treatment of choice for SHPT in chronic hemodialysis patients, especially for those with resistant hyperparathyroidism, which does not respond adequately to alfacalcidol. (renalandurologynews.com)
- Short- and long-term outcome of patients with pseudo-vitamin D deficiency rickets treated with calcitriol. (biomedsearch.com)
- MATERIALS AND METHODS: Thirty-nine patients (20 females) with PDDR received calcitriol for periods of 2.0-26 yr. (biomedsearch.com)
- In 21 patients, data were available at diagnosis and during the first 2 yr of treatment with calcitriol. (biomedsearch.com)
- As to long-term effects, adult patients who had received calcitriol before the pubertal growth spurt (n = 11) had normal height, whereas patients who were treated with calcitriol only after puberty (n = 14) on average were short (height z-score -2.2). (biomedsearch.com)
- Chronic kidney disease (CKD) patients are commonly treated with vitamin D analogs, such as calcitriol. (aspetjournals.org)
- These findings suggest that modifying the adverse effect profile of calcitriol with Mg may be a plausible approach to benefiting CKD patients prescribed calcitriol. (aspetjournals.org)
- During the study period, 12 (3%) calcitriol users and 40 (4%) control patients were lost to follow-up. (asnjournals.org)
- 2. The effect of the partial suppression of hyperparathyroidism by intravenous calcitriol on lipid levels and glucose tolerance was studied in 15 haemodialysis patients with secondary hyperparathyroidism. (portlandpress.com)
- 3. Before calcitriol treatment, uraemic patients with secondary hyperparathyroidism displayed a significant higher triglyceride and a significant lower HDL-C and apoprotein A-I as well as marked glucose intolerance with an increment of the area below the glucose curve when compared with healthy control subjects. (portlandpress.com)
- Conclusions Six months of therapy with calcitriol or cholecalciferol did not improve vascular endothelial function or improve inflammation in patients with CKD. (asnjournals.org)
- 33 patients who had received calcitriol for at least one year and up to 7 years were carefully matched with controls for gender, years on hemodialysis and severity of radiological hyperparathyroidism both at the start of haemodialysis and at the start of the study. (ox.ac.uk)
- Calcitriol dose-normalized AUC versus creatinine clearance in individual patients following the administration of a single dose of DN-101. (aacrjournals.org)
- Calcitriol (0.5 µg calcitriol twice per week) has been effective in decreasing proteinuria in patients with IgA nephropathy. (vitamindwiki.com)
Topical6
- Calcitriol topical is used to treat mild to moderate plaque psoriasis (a skin disease in which red, scaly patches form on some areas of the body) in adults and children 2 years of age and older. (medlineplus.gov)
- tell your doctor and pharmacist if you are allergic to calcitriol, any other medications, or any of the ingredients in calcitriol topical. (medlineplus.gov)
- If you are breastfeeding while using calcitriol topical, do not apply it directly to the nipple and areola (the colored area around each nipple). (medlineplus.gov)
- Calcitriol topical may cause side effects. (medlineplus.gov)
- There are no evaluations for Calcitriol topical. (patientslikeme.com)
- but, i have not been able to find anything published linking topical application to serum calcitriol status. (thisisms.com)
Inhibition3
Hyperparathyroidism1
- Because of hypercalciuria as a side effect from calcitriol therapy, treatment was continued with paricalcitol, a vitamin D analogue used in secondary hyperparathyroidism in chronic kidney disease. (hindawi.com)
Combined phosphate1
- Improved growth rate in XLR children occured by combined phosphate and calcitriol treatment before 18 months. (nih.gov)
Elevated calcitriol levels1
- The major conditions with hypercalcaemia due to elevated calcitriol levels are lymphoma, tuberculosis and sarcoidosis where excess production occurs due to ectopic 25(OH)D-1-hydroxylase (CYP27B1) expressed in macrophages. (wikipedia.org)
Inhibits3
- 1 alpha,25-Dihydroxyvitamin D (calcitriol) inhibits the invasiveness of human prostate cancer cells. (aacrjournals.org)
- Calcitriol sensitization inhibits the migration of 143B-P cells in matrigel whereas no significant difference was observed in control and calcitriol treated 143B-MM cells. (ku.edu)
- FGF-23 inhibits one-α-hydroxylase in the kidney and stimulates 24-hydroxylase action, thereby reducing calcitriol synthesis and growing calcitriol metabolic process to the inactive one,24,25(OH)3-vitamin D.105 In addition, FGF-23 inhibits the secretion of PTH prior to uremia is superior, but this is a minor effect as the big regulator of PTH secretion is serum iCa. (wallinside.com)
Prescription buying cal1
- products produced from animals such as butter, order generic calcitriol no prescription buy calcitriol uk no prescription buying calcitriol on the internet uk ordering calcitriol online from australia buy generic calcitriol online usa buying calcitriol from australia since the herniation exists outside the neuroforaminal opening. (purevolume.com)
Receptor6
- A calcitriol receptor-binding protein appears to exist in the mucosa of human intestine. (nih.gov)
- For instance, the unbound inactive form of the calcitriol receptor in intestinal epithelial cells resides in the cytoplasm. (wikipedia.org)
- Proteins, usually found in the cytoplasm, that specifically bind calcitriol, migrate to the nucleus, and regulate transcription of specific segments of DNA with the participation of D receptor interacting proteins (called DRIP). (curehunter.com)
- 4. No differences between PVDRI and control piglets were also found for the relative molecular mass (47 500 and 47700, respectively) and the Stokes' radius (3.04 and 3.05 nm, respectively) of the calcitriol receptor. (portlandpress.com)
- 5. It is concluded that the intestinal calcitriol receptor of this animal model functions normally and that changes in binding properties and concentration of the intestinal calcitriol receptor do not contribute to the development of rachitic lesions in PVDRI piglets. (portlandpress.com)
- The kinetics of human amyloid-β (hAβ) 40 were examined in the rat pursuant to intravenous and intracerebroventricular administration after pretreatment with calcitriol, the active vitamin D receptor ligand (6.4 nmol·kg −1 in 0.3 ml corn oil every other day for four intraperitoneal doses) to induce P-glycoprotein (P-gp) and enhance hAβ 40 brain efflux. (aspetjournals.org)
Analogs4
- Calcitriol is in a class of medications called vitamin D analogs. (medlineplus.gov)
- Research on the noncalcemic actions of calcitriol and other VDR-ligand analogs and their possible therapeutic applications has been reviewed. (wikipedia.org)
- The Potential Role of Calcitriol Analogs in the Management of Breast Cancer. (dtic.mil)
- Furthermore they suggest that early markers of inflammatory dendritic cell and Th17 differentiation qualify as new target molecules for both calcitriol and highly selective immune-modulating vitamin D analogs. (aspetjournals.org)
Interact with calcitriol2
- Many other medications may also interact with calcitriol, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list. (medlineplus.gov)
- Which drugs or supplements interact with calcitriol? (medicinenet.com)
Combination Of Calcitriol1
- The combination of calcitriol and an AI may have potential benefits for BCa therapy. (nih.gov)
Kidney5
- If you do not have kidney disease, you should drink plenty of fluids while taking calcitriol. (medlineplus.gov)
- Additional evidence suggests that calcitriol may also act on the kidney and the parathyroid glands. (nih.gov)
- Vitamin D is converted in the liver and kidney to calcitriol and ultimately acts through these receptors. (curehunter.com)
- Megalin is important in regulating the response of the NaPi-IIa transporter to PTH that results in phosphaturia and calcitriol upregulates megalin expression in the kidney.10 The effects of PTH are rapid and the outcomes of FGF-23 acquire a lot more time. (wallinside.com)
- A third important effect of PTH on the kidney is its stimulation of the conversion of 25-hydroxy vitamin D into 1,25-dihydroxy vitamin D (calcitriol), which is released into the circulation. (wikipedia.org)
Vitamin D metabolite3
- 1,25-(OH) 2 D 3 (calcitriol) is an active vitamin D metabolite. (dovepress.com)
- Four children of 2 families had alopecia associated with severe rickets, resistant to treatment and caused by defective cytoplasmic and nuclear receptors for the active vitamin D metabolite calcitriol (1,25-dihydroxycholecalciferol). (eurekamag.com)
- 1 - 4 The kidneys play an important role in converting 25-hydroxyvitamin D to calcitriol, the most biologically potent vitamin D metabolite, under regulation by parathyroid hormone (PTH) and phosphate. (asnjournals.org)
Parathyroid hormone levels2
- In someone with hypercalcaemia and high calcitriol levels, low intact parathyroid hormone levels are usually present. (wikipedia.org)
- The association of calcitriol with improved survival was not statistically different across baseline parathyroid hormone levels. (asnjournals.org)
Differentiation3
- OVA323-339/calcitriol liposomes suppressed expansion, differentiation, and function of Teffs and induced Foxp3+ and IL-10+ peripheral Tregs in an antigen-specific manner, which was dependent on PD-L1. (nih.gov)
- Liposomes encapsulating calcitriol and disease-associated peptides suppressed the severity of rheumatoid arthritis and Goodpasture's vasculitis models with suppression of antigen-specific memory T cell differentiation and function. (nih.gov)
- Design: Previous findings in our lab suggests, calcitriol act as differentiation agent in human osteosarcoma cell lines 143B and SaOS-2. (ku.edu)
Medications1
- Separating the administration of these medications and calcitriol may prevent this interaction. (medicinenet.com)
Concentrations5
- Phenytoin ( Dilantin ) and phenobarbital (Luminal) may reduce blood concentrations of calcitriol, decreasing treatment effectiveness. (medicinenet.com)
- 1. Calcitriol (1,25-dihydroxyvitamin D 3 ) concentrations in plasma of humans and pigs with pseudo-vitamin D deficiency rickets type I (PVDRI) have been reported to be significantly lower than in normal subjects and animals. (portlandpress.com)
- Sometimes, however, calcitriol concentrations are relatively high in these subjects and animals (50-80 pmol/l) and nevertheless clinical symptoms of rickets develop. (portlandpress.com)
- PVDRI piglets with clinical and biochemical symptoms of rickets (hypocalcaemia, increased activity of alkaline phosphatase) and with calcitriol concentrations in plasma of 83.7 ± 4.2 pmol/l ( n = 7) were used. (portlandpress.com)
- They were compared with unaffected piglets with normal calcitriol concentrations (178.0 ± 17.7 pmol/l, n = 9). (portlandpress.com)
Rickets1
- Calcitriol is also sometimes used to treat rickets (softening and weakening of bones in children caused by lack of vitamin D), osteomalacia (softening and weakening of bones in adults caused by lack of vitamin D), and familial hypophosphatemia (rickets or osteomalacia caused by decreased ability to break down vitamin D in the body). (medlineplus.gov)
Capsules2
Take calcitriol5
- Take calcitriol exactly as directed. (medlineplus.gov)
- Your doctor will probably tell you not to take calcitriol. (medlineplus.gov)
- To make sure you can safely take calcitriol, tell your doctor about all of your medical conditions. (cigna.com)
- How should I take calcitriol? (cigna.com)
- Can I take Calcitriol (GenRx) in sport? (healthdirect.gov.au)
High calcitriol1
- but, if high calcitriol is your objective, this analogue would probably do the trick. (thisisms.com)
Order calcitriol2
- Order CALCITRIOL at sale prices! (gravatar.com)
- order calcitriol online reviews where can i buy calcitriol using paypal and this is why it is important to do research to make sure that it stands a chance of working. (gravatar.com)
Global Calcitriol3
- There are 15 Chapters to deeply display the global Calcitriol (CAS 32222-06-3) market. (beforeitsnews.com)
- In this report, the global Calcitriol (CAS 32222-06-3) market is valued at USD XX million in 2016 and is expected to reach USD XX million by the end of 2022, growing at a CAGR of XX% between 2016 and 2022. (reportsnreports.com)
- This report focuses on the Global Calcitriol (CAS 32222-06-3) Market trends, future forecasts, growth opportunities, key end-user industries, and market players. (thewoodsnewspaper.com)
Calcijex1
- The lowest price for Calcijex inj (calcitriol) 1 mcg/ml is $53.42 per mcg/ml for 1 mcg/mls at PharmacyChecker-accredited online pharmacies. (pharmacychecker.com)
Serum PTH levels2
- 5 , 6 A decline in calcitriol levels and a rise in serum PTH levels are among the first detectable mineral metabolism disturbances in CKD. (asnjournals.org)
- Compared with matched control subjects, calcitriol users had higher serum PTH levels, modestly lower eGFR, more nephrology clinic visits, and a slightly greater prevalence of comorbid conditions. (asnjournals.org)
Efficacy2
- Therefore, the investigators plan to conduct a randomized clinical study to evaluate the efficacy of Calcitriol in the treatment of IgA nephropathy. (clinicaltrials.gov)
- In a study, calcitriol showed superior efficacy compared with alfacalcidol with respect to inhibiting parathyroid hormone secretion. (renalandurologynews.com)