AnatomyDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesTechnology, Industry, AgricultureGeographicals
CalcitriolReceptors, CalcitriolCalcium Channel AgonistsHyperparathyroidism, SecondaryParathyroid HormoneErgocalciferolsVitaminsParathyroid GlandsHypercalcemiaPhosphorusVitamin DHypocalcemiaCalciumRenal OsteodystrophyUremia25-Hydroxyvitamin D3 1-alpha-HydroxylaseHyperparathyroidismSteroid HydroxylasesCalcifediolPacific StatesVitamin D Response ElementPhosphatesCholecalciferolHypoparathyroidismOsteomalaciaRenal DialysisParathyroidectomyPhosphorus, DietaryBone Density Conservation AgentsRicketsHypophosphatemia, FamilialHypophosphatemiaCalcium CarbonateBone and BonesAstemizoleSulfadimethoxineOsteocalcinAlkaline PhosphataseFamilial Hypophosphatemic RicketsAdministration, OralKidney Failure, ChronicS100 Calcium Binding Protein GCholestanetriol 26-MonooxygenaseReceptors, Calcium-SensingIdahoVitamin D DeficiencyHydroxyprostaglandin Dehydrogenases25-Hydroxyvitamin D 2HydroxycholecalciferolsDihydroxycholecalciferolsPulse Therapy, DrugProstatic NeoplasmsDose-Response Relationship, DrugFibroblast Growth FactorsCalcium GluconatePhosphorus Metabolism DisordersCalbindinsEtidronic AcidKidneys, ArtificialInjections, IntravenousAnnexin A6Calcium, DietaryBone ResorptionNephrectomyPharmaceutical VehiclesDrug SynergismInjections, IntralesionalDexamethasoneAlendronateRenal Insufficiency, ChronicCalcimimetic Agents
Calcitriol
The physiologically active form of vitamin D. It is formed primarily in the kidney by enzymatic hydroxylation of 25-hydroxycholecalciferol (CALCIFEDIOL). Its production is stimulated by low blood calcium levels and parathyroid hormone. Calcitriol increases intestinal absorption of calcium and phosphorus, and in concert with parathyroid hormone increases bone resorption.
Receptors, Calcitriol
Proteins, usually found in the cytoplasm, that specifically bind calcitriol, migrate to the nucleus, and regulate transcription of specific segments of DNA with the participation of D receptor interacting proteins (called DRIP). Vitamin D is converted in the liver and kidney to calcitriol and ultimately acts through these receptors.
Calcium Channel Agonists
Agents that increase calcium influx into calcium channels of excitable tissues. This causes vasoconstriction in VASCULAR SMOOTH MUSCLE and/or CARDIAC MUSCLE cells as well as stimulation of insulin release from pancreatic islets. Therefore, tissue-selective calcium agonists have the potential to combat cardiac failure and endocrinological disorders. They have been used primarily in experimental studies in cell and tissue culture.
Hyperparathyroidism, Secondary
Abnormally elevated PARATHYROID HORMONE secretion as a response to HYPOCALCEMIA. It is caused by chronic KIDNEY FAILURE or other abnormalities in the controls of bone and mineral metabolism, leading to various BONE DISEASES, such as RENAL OSTEODYSTROPHY.
Parathyroid Hormone
A polypeptide hormone (84 amino acid residues) secreted by the PARATHYROID GLANDS which performs the essential role of maintaining intracellular CALCIUM levels in the body. Parathyroid hormone increases intracellular calcium by promoting the release of CALCIUM from BONE, increases the intestinal absorption of calcium, increases the renal tubular reabsorption of calcium, and increases the renal excretion of phosphates.
Ergocalciferols
Derivatives of ERGOSTEROL formed by ULTRAVIOLET RAYS breaking of the C9-C10 bond. They differ from CHOLECALCIFEROL in having a double bond between C22 and C23 and a methyl group at C24.
Vitamins
Organic substances that are required in small amounts for maintenance and growth, but which cannot be manufactured by the human body.
Parathyroid Glands
Two pairs of small oval-shaped glands located in the front and the base of the NECK and adjacent to the two lobes of THYROID GLAND. They secrete PARATHYROID HORMONE that regulates the balance of CALCIUM; PHOSPHORUS; and MAGNESIUM in the body.
Hypercalcemia
Abnormally high level of calcium in the blood.
Phosphorus
A non-metal element that has the atomic symbol P, atomic number 15, and atomic weight 31. It is an essential element that takes part in a broad variety of biochemical reactions.
Vitamin D
A vitamin that includes both CHOLECALCIFEROLS and ERGOCALCIFEROLS, which have the common effect of preventing or curing RICKETS in animals. It can also be viewed as a hormone since it can be formed in SKIN by action of ULTRAVIOLET RAYS upon the precursors, 7-dehydrocholesterol and ERGOSTEROL, and acts on VITAMIN D RECEPTORS to regulate CALCIUM in opposition to PARATHYROID HORMONE.
Hypocalcemia
Reduction of the blood calcium below normal. Manifestations include hyperactive deep tendon reflexes, Chvostek's sign, muscle and abdominal cramps, and carpopedal spasm. (Dorland, 27th ed)
Calcium
A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.
Renal Osteodystrophy
Decalcification of bone or abnormal bone development due to chronic KIDNEY DISEASES, in which 1,25-DIHYDROXYVITAMIN D3 synthesis by the kidneys is impaired, leading to reduced negative feedback on PARATHYROID HORMONE. The resulting SECONDARY HYPERPARATHYROIDISM eventually leads to bone disorders.
Uremia
A clinical syndrome associated with the retention of renal waste products or uremic toxins in the blood. It is usually the result of RENAL INSUFFICIENCY. Most uremic toxins are end products of protein or nitrogen CATABOLISM, such as UREA or CREATININE. Severe uremia can lead to multiple organ dysfunctions with a constellation of symptoms.
25-Hydroxyvitamin D3 1-alpha-Hydroxylase
A mitochondrial cytochrome P450 enzyme that catalyzes the 1-alpha-hydroxylation of 25-hydroxyvitamin D3 (also known as 25-hydroxycholecalciferol) in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP27B1 gene, converts 25-hydroxyvitamin D3 to 1-alpha,25-dihydroxyvitamin D3 which is the active form of VITAMIN D in regulating bone growth and calcium metabolism. This enzyme is also active on plant 25-hydroxyvitamin D2 (ergocalciferol).
Hyperparathyroidism
A condition of abnormally elevated output of PARATHYROID HORMONE (or PTH) triggering responses that increase blood CALCIUM. It is characterized by HYPERCALCEMIA and BONE RESORPTION, eventually leading to bone diseases. PRIMARY HYPERPARATHYROIDISM is caused by parathyroid HYPERPLASIA or PARATHYROID NEOPLASMS. SECONDARY HYPERPARATHYROIDISM is increased PTH secretion in response to HYPOCALCEMIA, usually caused by chronic KIDNEY DISEASES.
Steroid Hydroxylases
Cytochrome P-450 monooxygenases (MIXED FUNCTION OXYGENASES) that are important in steroid biosynthesis and metabolism.
Calcifediol
The major circulating metabolite of VITAMIN D3. It is produced in the LIVER and is the best indicator of the body's vitamin D stores. It is effective in the treatment of RICKETS and OSTEOMALACIA, both in azotemic and non-azotemic patients. Calcifediol also has mineralizing properties.
Pacific States
The geographic designation for states bordering on or located in the Pacific Ocean. The states so designated are Alaska, California, Hawaii, Oregon, and Washington. (U.S. Geologic Survey telephone communication)
Vitamin D Response Element
A DNA sequence that is found in the promoter region of vitamin D regulated genes. Vitamin D receptor (RECEPTOR, CALCITRIOL) binds to and regulates the activity of genes containing this element.
Phosphates
Inorganic salts of phosphoric acid.
Cholecalciferol
Derivative of 7-dehydroxycholesterol formed by ULTRAVIOLET RAYS breaking of the C9-C10 bond. It differs from ERGOCALCIFEROL in having a single bond between C22 and C23 and lacking a methyl group at C24.
Hypoparathyroidism
A condition caused by a deficiency of PARATHYROID HORMONE (or PTH). It is characterized by HYPOCALCEMIA and hyperphosphatemia. Hypocalcemia leads to TETANY. The acquired form is due to removal or injuries to the PARATHYROID GLANDS. The congenital form is due to mutations of genes, such as TBX1; (see DIGEORGE SYNDROME); CASR encoding CALCIUM-SENSING RECEPTOR; or PTH encoding parathyroid hormone.
Osteomalacia
Disorder caused by an interruption of the mineralization of organic bone matrix leading to bone softening, bone pain, and weakness. It is the adult form of rickets resulting from disruption of VITAMIN D; PHOSPHORUS; or CALCIUM homeostasis.
Renal Dialysis
Therapy for the insufficient cleansing of the BLOOD by the kidneys based on dialysis and including hemodialysis, PERITONEAL DIALYSIS, and HEMODIAFILTRATION.
Parathyroidectomy
Excision of one or more of the parathyroid glands.
Phosphorus, Dietary
Phosphorus used in foods or obtained from food. This element is a major intracellular component which plays an important role in many biochemical pathways relating to normal physiological functions. High concentrations of dietary phosphorus can cause nephrocalcinosis which is associated with impaired kidney function. Low concentrations of dietary phosphorus cause an increase in calcitriol in the blood and osteoporosis.
Bone Density Conservation Agents
Agents that inhibit BONE RESORPTION and/or favor BONE MINERALIZATION and BONE REGENERATION. They are used to heal BONE FRACTURES and to treat METABOLIC BONE DISEASES such as OSTEOPOROSIS.
Rickets
Disorders caused by interruption of BONE MINERALIZATION manifesting as OSTEOMALACIA in adults and characteristic deformities in infancy and childhood due to disturbances in normal BONE FORMATION. The mineralization process may be interrupted by disruption of VITAMIN D; PHOSPHORUS; or CALCIUM homeostasis, resulting from dietary deficiencies, or acquired, or inherited metabolic, or hormonal disturbances.
Hypophosphatemia, Familial
An inherited condition of abnormally low serum levels of PHOSPHATES (below 1 mg/liter) which can occur in a number of genetic diseases with defective reabsorption of inorganic phosphorus by the PROXIMAL RENAL TUBULES. This leads to phosphaturia, HYPOPHOSPHATEMIA, and disturbances of cellular and organ functions such as those in X-LINKED HYPOPHOSPHATEMIC RICKETS; OSTEOMALACIA; and FANCONI SYNDROME.
Hypophosphatemia
A condition of an abnormally low level of PHOSPHATES in the blood.
Calcium Carbonate
Carbonic acid calcium salt (CaCO3). An odorless, tasteless powder or crystal that occurs in nature. It is used therapeutically as a phosphate buffer in hemodialysis patients and as a calcium supplement.
Bone and Bones
A specialized CONNECTIVE TISSUE that is the main constituent of the SKELETON. The principle cellular component of bone is comprised of OSTEOBLASTS; OSTEOCYTES; and OSTEOCLASTS, while FIBRILLAR COLLAGENS and hydroxyapatite crystals form the BONE MATRIX.
Astemizole
Antihistamine drug now withdrawn from the market in many countries because of rare but potentially fatal side effects.
Sulfadimethoxine
A sulfanilamide that is used as an anti-infective agent.
Osteocalcin
Vitamin K-dependent calcium-binding protein synthesized by OSTEOBLASTS and found primarily in BONES. Serum osteocalcin measurements provide a noninvasive specific marker of bone metabolism. The protein contains three residues of the amino acid gamma-carboxyglutamic acid (Gla), which, in the presence of CALCIUM, promotes binding to HYDROXYAPATITE and subsequent accumulation in BONE MATRIX.
Alkaline Phosphatase
An enzyme that catalyzes the conversion of an orthophosphoric monoester and water to an alcohol and orthophosphate. EC 3.1.3.1.
Familial Hypophosphatemic Rickets
A hereditary disorder characterized by HYPOPHOSPHATEMIA; RICKETS; OSTEOMALACIA; renal defects in phosphate reabsorption and vitamin D metabolism; and growth retardation. Autosomal and X-linked dominant and recessive variants have been reported.
Administration, Oral
The giving of drugs, chemicals, or other substances by mouth.
Kidney Failure, Chronic
The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION.
S100 Calcium Binding Protein G
A calbindin protein found in many mammalian tissues, including the UTERUS, PLACENTA, BONE, PITUITARY GLAND, and KIDNEYS. In intestinal ENTEROCYTES it mediates intracellular calcium transport from apical to basolateral membranes via calcium binding at two EF-HAND MOTIFS. Expression is regulated in some tissues by VITAMIN D.
Cholestanetriol 26-Monooxygenase
An NAPH-dependent cytochrome P450 enzyme that catalyzes the oxidation of the side chain of sterol intermediates such as the 27-hydroxylation of 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol.
Receptors, Calcium-Sensing
A class of G-protein-coupled receptors that react to varying extracellular CALCIUM levels. Calcium-sensing receptors in the PARATHYROID GLANDS play an important role in the maintenance of calcium HOMEOSTASIS by regulating the release of PARATHYROID HORMONE. They differ from INTRACELLULAR CALCIUM-SENSING PROTEINS which sense intracellular calcium levels.
Idaho
Vitamin D Deficiency
A nutritional condition produced by a deficiency of VITAMIN D in the diet, insufficient production of vitamin D in the skin, inadequate absorption of vitamin D from the diet, or abnormal conversion of vitamin D to its bioactive metabolites. It is manifested clinically as RICKETS in children and OSTEOMALACIA in adults. (From Cecil Textbook of Medicine, 19th ed, p1406)
Hydroxyprostaglandin Dehydrogenases
Catalyzes reversibly the oxidation of hydroxyl groups of prostaglandins.
25-Hydroxyvitamin D 2
9,10-Secoergosta-5,7,10(19),22-tetraene-3,25-diol. Biologically active metabolite of vitamin D2 which is more active in curing rickets than its parent. The compound is believed to attach to the same receptor as vitamin D2 and 25-hydroxyvitamin D3.
Hydroxycholecalciferols
Hydroxy analogs of vitamin D 3; (CHOLECALCIFEROL); including CALCIFEDIOL; CALCITRIOL; and 24,25-DIHYDROXYVITAMIN D 3.
Dihydroxycholecalciferols
Cholecalciferols substituted with two hydroxy groups in any position.
Pulse Therapy, Drug
Administration of high doses of pharmaceuticals over short periods of time.
Prostatic Neoplasms
Tumors or cancer of the PROSTATE.
Dose-Response Relationship, Drug
The relationship between the dose of an administered drug and the response of the organism to the drug.
Fibroblast Growth Factors
A family of small polypeptide growth factors that share several common features including a strong affinity for HEPARIN, and a central barrel-shaped core region of 140 amino acids that is highly homologous between family members. Although originally studied as proteins that stimulate the growth of fibroblasts this distinction is no longer a requirement for membership in the fibroblast growth factor family.
Calcium Gluconate
The calcium salt of gluconic acid. The compound has a variety of uses, including its use as a calcium replenisher in hypocalcemic states.
Phosphorus Metabolism Disorders
Disorders in the processing of phosphorus in the body: its absorption, transport, storage, and utilization.
Calbindins
Calcium-binding proteins that are found in DISTAL KIDNEY TUBULES, INTESTINES, BRAIN, and other tissues where they bind, buffer and transport cytoplasmic calcium. Calbindins possess a variable number of EF-HAND MOTIFS which contain calcium-binding sites. Some isoforms are regulated by VITAMIN D.
Etidronic Acid
A diphosphonate which affects calcium metabolism. It inhibits ectopic calcification and slows down bone resorption and bone turnover.
Kidneys, Artificial
Devices which can substitute for normally functioning KIDNEYS in removing components from the blood by DIALYSIS that are normally eliminated in the URINE.
Injections, Intravenous
Injections made into a vein for therapeutic or experimental purposes.
Annexin A6
Protein of the annexin family with a probable role in exocytotic and endocytotic membrane events.
Calcium, Dietary
Calcium compounds used as food supplements or in food to supply the body with calcium. Dietary calcium is needed during growth for bone development and for maintenance of skeletal integrity later in life to prevent osteoporosis.
Bone Resorption
Bone loss due to osteoclastic activity.
Nephrectomy
Excision of kidney.
Pharmaceutical Vehicles
A carrier or inert medium used as a solvent (or diluent) in which the medicinally active agent is formulated and or administered. (Dictionary of Pharmacy, 1986)
Drug Synergism
The action of a drug in promoting or enhancing the effectiveness of another drug.
Injections, Intralesional
Injections introduced directly into localized lesions.
Dexamethasone
An anti-inflammatory 9-fluoro-glucocorticoid.
Alendronate
A nonhormonal medication for the treatment of postmenopausal osteoporosis in women. This drug builds healthy bone, restoring some of the bone loss as a result of osteoporosis.
Renal Insufficiency, Chronic
Conditions in which the KIDNEYS perform below the normal level for more than three months. Chronic kidney insufficiency is classified by five stages according to the decline in GLOMERULAR FILTRATION RATE and the degree of kidney damage (as measured by the level of PROTEINURIA). The most severe form is the end-stage renal disease (CHRONIC KIDNEY FAILURE). (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002)
Calcimimetic Agents
Small organic molecules that act as allosteric activators of the calcium sensing receptor (CaSR) in the PARATHYROID GLANDS and other tissues. They lower the threshold for CaSR activation by extracellular calcium ions and diminish PARATHYROID HORMONE (PTH) release from parathyroid cells.

Vitamin D regulates human ectocervical epithelial cell proliferation and insulin-like growth factor-binding protein-3 level. (1/2474)

The differentiation status of the cervical epithelial cell has an important influence on responsiveness to estrogens and progestins. Several agents, including glucocorticoids and retinoids, are known to influence cervical cell differentiation. However, the effects of vitamin D have not been examined. Vitamin D is known to regulate cell proliferation and gene expression in a variety of epithelial cells. In the present study we investigated the ability of 1alpha25-dihydroxyvitamin D3 (D3) to regulate cell proliferation and expression of insulin-like growth factor-binding protein-3 (IGFBP-3) in human ectocervical epithelial cells. ECE16-1, a non-tumorigenic cervical cell line, was growth inhibited by D3 with maximal inhibition at 1000 nM. IGFBP-3 levels increased in parallel with the growth inhibition. IGFBP-3 levels were half-maximally increased at approximately 10-100 nM and maximally increased (10- to 30-fold) at 1000 nM D3. These studies show that vitamin D regulates cervical epithelial cell gene regulation and cell proliferation and that IGFBP-3 may be an in vivo marker of vitamin D action in the cervix.  (+info)

22-oxacalcitriol suppresses secondary hyperparathyroidism without inducing low bone turnover in dogs with renal failure. (2/2474)

BACKGROUND: Calcitriol therapy suppresses serum levels of parathyroid hormone (PTH) in patients with renal failure but has several drawbacks, including hypercalcemia and/or marked suppression of bone turnover, which may lead to adynamic bone disease. A new vitamin D analogue, 22-oxacalcitriol (OCT), has been shown to have promising characteristics. This study was undertaken to determine the effects of OCT on serum PTH levels and bone turnover in states of normal or impaired renal function. METHODS: Sixty dogs were either nephrectomized (Nx, N = 38) or sham-operated (Sham, N = 22). The animals received supplemental phosphate to enhance PTH secretion. Fourteen weeks after the start of phosphate supplementation, half of the Nx and Sham dogs received doses of OCT (three times per week); the other half were given vehicle for 60 weeks. Thereafter, the treatment modalities for a subset of animals were crossed over for an additional eight months. Biochemical and hormonal indices of calcium and bone metabolism were measured throughout the study, and bone biopsies were done at baseline, 60 weeks after OCT or vehicle treatment, and at the end of the crossover period. RESULTS: In Nx dogs, OCT significantly decreased serum PTH levels soon after the induction of renal insufficiency. In long-standing secondary hyperparathyroidism, OCT (0.03 microg/kg) stabilized serum PTH levels during the first months. Serum PTH levels rose thereafter, but the rise was less pronounced compared with baseline than the rise seen in Nx control. These effects were accompanied by episodes of hypercalcemia and hyperphosphatemia. In animals with normal renal function, OCT induced a transient decrease in serum PTH levels at a dose of 0.1 microg/kg, which was not sustained with lowering of the doses. In Nx dogs, OCT reversed abnormal bone formation, such as woven osteoid and fibrosis, but did not significantly alter the level of bone turnover. In addition, OCT improved mineralization lag time, (that is, the rate at which osteoid mineralizes) in both Nx and Sham dogs. CONCLUSIONS: These results indicate that even though OCT does not completely prevent the occurrence of hypercalcemia in experimental dogs with renal insufficiency, it may be of use in the management of secondary hyperparathyroidism because it does not induce low bone turnover and, therefore, does not increase the risk of adynamic bone disease.  (+info)

Serum levels of 1,25-dihydroxyvitamin D, 24,25-dihydroxyvitamin D, and 25-hydroxyvitamin D in nondialyzed patients with chronic renal failure. (3/2474)

BACKGROUND: In patients with chronic renal failure (CRF), abnormalities in vitamin D metabolism are known to be present, and several factors could contribute to the abnormalities. METHODS: We measured serum levels of three vitamin D metabolites, 1,25(OH)2D, 24, 25(OH)2D and 25(OH)D, and analyzed factors affecting their levels in 76 nondialyzed patients with CRF (serum creatinine> 1.6 and < 9.0 mg/dl), 37 of whom had diabetes mellitus (DM-CRF) and 39 of whom were nondiabetic (nonDM-CRF). RESULTS: Serum levels of 1,25(OH)2D were positively correlated with estimated creatinine clearance (CCr; r = 0.429; P < 0.0001), and levels of 24,25(OH)2D were weakly correlated with CCr (r = 0.252, P < 0.05); no correlation was noted for 25(OH)D. Serum levels of all three vitamin D metabolites were significantly and positively correlated with serum albumin. Although there were no significant differences in age, sex, estimated CCr, calcium and phosphate between DM-CRF and nonDM-CRF, all three vitamin D metabolites were significantly lower in DM-CRF than in nonDM-CRF. To analyze factors influencing vitamin D metabolite levels, we performed multiple regression analyses. Serum 25(OH)D levels were significantly and independently associated with serum albumin, presence of DM and serum phosphate (R2 = 0.599; P < 0.0001). 24,25(OH)2D levels were significantly and strongly associated with 25(OH)D (beta = 0.772; R2 = 0.446; P < 0.0001). Serum 1,25(OH)2D levels were significantly associated only with estimated CCr (R2 = 0. 409; P < 0.0001). CONCLUSIONS: These results suggest that hypoalbuminemia and the presence of DM independently affect serum 25(OH)D levels, probably via diabetic nephropathy and poor nutritional status associated with diabetes, and that 25(OH)D is actively catalyzed to 24,25(OH)2D in CRF, probably largely via extrarenal 24-hydroxylase. Serum levels of 1,25(OH)2D were significantly affected by the degree of renal failure. Thus, this study indicates that patients with CRF, particularly those with DM, should receive supplements containing the active form of vitamin D prior to dialysis.  (+info)

1,25-Dihydroxyvitamin D3 enhances the susceptibility of breast cancer cells to doxorubicin-induced oxidative damage. (4/2474)

1,25-Dihydroxyvitamin D3 (1,25(OH)2D3), the hormonal form of vitamin D, has anticancer activity in vivo and in vitro. Doxorubicin exerts its cytotoxic effect on tumor cells mainly by two mechanisms: (a) generation of reactive oxygen species (ROS); and (b) inhibition of topoisomerase II. We studied the combined cytotoxic action of 1,25(OH)2D3 and doxorubicin on MCF-7 breast cancer cells. Pretreatement with 1,25(OH)2D3 resulted in enhanced cytotoxicity of doxorubicin. The average enhancing effect after a 72-h pretreatment with 1,25(OH)2D3 (10 nM) followed by a 24-h treatment with 1 microg/ml doxorubicin was 74+/-9% (mean +/- SE). Under these experimental conditions, 1,25(OH)2D3 on its own did not affect cell number or viability. 1,25(OH)2D3 also enhanced the cytotoxic activity of another ROS generating quinone, menadione, but did not affect cytotoxicity induced by the topoisomerase inhibitor etoposide. The antioxidant N-acetylcysteine slightly reduced the cytotoxic activity of doxorubicin but had a marked protective effect against the combined action of 1,25(OH)2D3 and doxorubicin. These results indicate that ROS are involved in the interaction between 1,25(OH)2D3 and doxorubicin. 1,25(OH)2D3 also increased doxorubicin cytotoxicity in primary cultures of rat cardiomyocytes. Treatment of MCF-7 cells with 1,25(OH)2D3 alone markedly reduced the activity, protein, and mRNA levels of the cytoplasmic antioxidant enzyme Cu/Zn superoxide dismutase, which indicated that the hormone inhibits its biosynthesis. This reduction in the antioxidant capacity of the cells could account for the synergistic interaction between 1,25(OH)2D3 and doxorubicin and may also suggest increased efficacy of 1,25(OH)2D3 or its analogues in combination with other ROS-generating anticancer therapeutic modalities.  (+info)

Convergence of transforming growth factor-beta and vitamin D signaling pathways on SMAD transcriptional coactivators. (5/2474)

Cell proliferation and differentiation are regulated by growth regulatory factors such as transforming growth factor-beta (TGF-beta) and the liphophilic hormone vitamin D. TGF-beta causes activation of SMAD proteins acting as coactivators or transcription factors in the nucleus. Vitamin D controls transcription of target genes through the vitamin D receptor (VDR). Smad3, one of the SMAD proteins downstream in the TGF-beta signaling pathway, was found in mammalian cells to act as a coactivator specific for ligand-induced transactivation of VDR by forming a complex with a member of the steroid receptor coactivator-1 protein family in the nucleus. Thus, Smad3 may mediate cross-talk between vitamin D and TGF-beta signaling pathways.  (+info)

Regulation of PiT-1, a sodium-dependent phosphate co-transporter in rat parathyroid glands. (6/2474)

A cDNA encoding an Na+-Pi co-transporter, termed rat PiT-1, has now been isolated from rat parathyroid. Expression of rat PiT-1 in Xenopus oocytes revealed that it possesses Na+-dependent Pi co-transport activity. The amount of PiT-1 mRNA in the parathyroid of vitamin D-deficient rats was reduced compared with that in normal animals, and increased markedly after administration of 1,25-dihydroxyvitamin D3. Furthermore, the abundance of PiT-1 mRNA in the parathyroid was much greater in rats fed a low-Pi diet than in those fed a high-Pi diet. Thus, rat PiT-1 may contribute to the effects of Pi and vitamin D on parathyroid function.  (+info)

Regulation of vitamin D action. (7/2474)

The control of gene transcription by vitamin D compounds is initiated by binding to the VDR, which enhances the receptor's ability to heterodimerize to RXR, interact with response elements in target genes and attract components of the transcriptional initiation complex. A number of factors are capable of influencing this process, including (i) the rate of uptake and catabolism of the ligand, (ii) the nature of the conformational change induced by a specific ligand, (iii) the cellular content of the VDR, (iv) post-translational modifications of the VDR and (v) the availability of other transcriptional components. Vitamin D analogues may affect these factors differently to 1,25(OH)2D3 to produce unique biological profiles that can be exploited for therapeutic use.  (+info)

Topical psoriasis therapy. (8/2474)

Psoriasis is a common dermatosis, affecting from 1 to 3 percent of the population. Until recently, the mainstays of topical therapy have been corticosteroids, tars, anthralins and keratolytics. Recently, however, vitamin D analogs, a new anthralin preparation and topical retinoids have expanded physicians' therapeutic armamentarium. These new topical therapies offer increased hope and convenience to the large patient population with psoriasis.  (+info)

Direct inhibitory effect of calcitriol on parathyroid function (sigmoidal curve) in dialysis<...Direct inhibitory effect of calcitriol on parathyroid function (sigmoidal curve) in dialysis<...
TY - JOUR. T1 - Direct inhibitory effect of calcitriol on parathyroid function (sigmoidal curve) in dialysis. AU - Dunlay, R.. AU - Rodriguez, M.. AU - Felsenfeld, A. J.. AU - Llach, F.. PY - 1989/1/1. Y1 - 1989/1/1. N2 - The effect of intravenous calcitriol on parathyroid function was evaluated in nine chronic hemodialysis patients with secondary hyperparathyroidism. Two micrograms of calcitriol were administered intravenously after dialysis thrice weekly for ten weeks. Parathyroid function was assessed by inducing hypo- and hypercalcemia with low calcium (1.0 mEq/liter) and high calcium (4.0 mEq/liter) dialyses before and after ten weeks of intravenous calcitriol therapy. To avoid hypercalcemia during calcitriol administration, the dialysate calcium was reduced to 2.5 mEq/liter. Parathyroid hormone (PTH) values (pg/ml) from dialysis-induced hypo- and hypercalcemia were plotted against serum ionized calcium, and the sigmoidal relationship between PTH and calcium was evaluated. Basal PTH levels ...
https://creighton.pure.elsevier.com/en/publications/direct-inhibitory-effect-of-calcitriol-on-parathyroid-function-si
Sequential versus combined treatment of human breast cancer cells with antiestrogens and the vitamin D analogue EB1089 and...Sequential versus combined treatment of human breast cancer cells with antiestrogens and the vitamin D analogue EB1089 and...
TY - JOUR. T1 - Sequential versus combined treatment of human breast cancer cells with antiestrogens and the vitamin D analogue EB1089 and evaluation of predictive markers for vitamin D treatment. AU - Christensen, G L. AU - Jepsen, J S. AU - Fog, C K. AU - Christensen, I J. AU - Lykkesfeldt, A E. PY - 2004/5. Y1 - 2004/5. N2 - Development of resistance to antihormonal therapy is a major problem in the treatment of breast cancer patients. Metastatic tumors, which progress after a period of response to treatment, often respond to second line endocrine treatment, but eventually develop estrogen independent growth. Vitamin D analogues are promising new drugs, using alternative mechanisms to inhibit growth of breast cancer cells. The sensitivity to antiestrogens and vitamin D analogues has been proposed to be inverse, indicating that the sensitivity to vitamin D analogues might increase after development of antiestrogen resistance and vice versa. In this study, the inverse sensitivity between ...
https://www.ucviden.dk/da/publications/sequential-versus-combined-treatment-of-human-breast-cancer-cells
Comparison of the Effects of Daily and Intermittent-Dose Calcitriol on Serum Parathyroid Hormone and Ionized Calcium...Comparison of the Effects of Daily and Intermittent-Dose Calcitriol on Serum Parathyroid Hormone and Ionized Calcium...
Hostutler, R. A., DiBartola, S. P., Chew, D. J., Nagode, L. A., Schenck, P. A., Rajala-Schultz, P. J. and Drost, W. T. (2006), Comparison of the Effects of Daily and Intermittent-Dose Calcitriol on Serum Parathyroid Hormone and Ionized Calcium Concentrations in Normal Cats and Cats with Chronic Renal Failure. Journal of Veterinary Internal Medicine, 20: 1307-1313. doi: 10.1111/j.1939-1676.2006.tb00743.x ...
http://onlinelibrary.wiley.com/doi/10.1111/j.1939-1676.2006.tb00743.x/references?globalMessage=0
1,25 Dihydroxyvitamin D circulating levels, calcitriol administration, and incidence of acute rejection, CMV infection, and...1,25 Dihydroxyvitamin D circulating levels, calcitriol administration, and incidence of acute rejection, CMV infection, and...
1,25 Dihydroxyvitamin D circulating levels, calcitriol administration, and incidence of acute rejection, CMV infection, and polyoma virus infection in renal transplant recipients ...
https://insights.ovid.com/clinical-transplantation/cltr/2016/10/000/25-dihydroxyvitamin-circulating-levels-calcitriol/23/00009046
Enhancement of vasoconstrictor response by a noncalcemic analogue of vitamin D3. | HypertensionEnhancement of vasoconstrictor response by a noncalcemic analogue of vitamin D3. | Hypertension
To clarify the effects of active vitamin D3 on pressor and vascular responses to vasoconstrictor substances, we studied pressor responses to the intravenous injection of norepinephrine or angiotensin II (Ang II) and vasoconstrictor responses to norepinephrine. Sprague-Dawley rats were given 1,25-dihydroxyvitamin D3 subcutaneously (200 ng/kg per day) for 14 days. The administration of 1,25-dihydroxyvitamin D3 augmented the pressor responses to norepinephrine and Ang II in conscious rats and was associated with a significant increase in serum calcium concentration (11.0 +/- 0.2 mg/dl). To further clarify whether the increased pressor response to vasoconstrictors may be due to the calcemic or direct action of active vitamin D3, we studied the effect of its noncalcemic analogue, 22-oxacalcitriol, and its inactive analogue, 24,25-dihydroxyvitamin D3, on the pressor response to vasoconstrictors in rats. The pressor responses to norepinephrine and Ang II were apparently augmented in ...
http://hyper.ahajournals.org/content/21/2/253
Calcitriol Plus Dexamethasone in Treating Patients With Prostate Cancer That Has Not Responded to Hormone Therapy - Full Text...Calcitriol Plus Dexamethasone in Treating Patients With Prostate Cancer That Has Not Responded to Hormone Therapy - Full Text...
OUTLINE: This is a dose-escalation study of calcitriol.. In the first stage of the study, cohorts of 3-6 patients receive escalating doses of oral calcitriol on days 1-3. Dose escalation continues until the maximum tolerated dose (MTD) is determined.. In the second stage, patients receive escalating doses of oral calcitriol on days 1-3 and a fixed dose of oral dexamethasone on days 0-4. Treatment continues weekly in the absence of disease progression or unacceptable toxicity. Dose escalation continues until the MTD is determined.. Six additional patients may receive calcitriol and dexamethasone at one dose level below the MTD determined in the second stage, to confirm the MTD.. The MTD is defined as the dose preceding that at which 2 of 3 or 2 of 6 patients experience dose-limiting toxicity.. PROJECTED ACCRUAL: Approximately 40 patients will be accrued for this study. ...
https://clinicaltrials.gov/ct2/show/NCT00010231
23,25-Dihydroxyvitamin D3: a natural precursor in the biosynthesis of 25-hydroxyvitamin D3-26,23-lactone | PNAS23,25-Dihydroxyvitamin D3: a natural precursor in the biosynthesis of 25-hydroxyvitamin D3-26,23-lactone | PNAS
To elucidate the biosynthesis of 25-hydroxyvitamin D3-26,23-lactone, two known metabolites of 25-hydroxyvitamin D3--23,25-dihydroxyvitamin D3 and 25,26-dihydroxyvitamin D3--were incubated individually with kidney homogenate prepared from vitamin D-supplemented chickens, a preparation known to produce the lactone from 25-hydroxyvitamin D3. The 25-hydroxyvitamin D3-26,23-lactone produced in vitro was then separated, purified, identified, and quantitated by consecutive straight-phase and reverse-phase high-performance liquid chromatography. 23,25-Dihydroxyvitamin D3 is a far better substrate for production of 25-hydroxyvitamin D3-26,23-lactone than is 25,26-dihydroxyvitamin D3. Production of lactone is highly selective for the natural 23(S)-hydroxy-23,25-dihydroxyvitamin D3 while both epimers of 25,26-dihydroxyvitamin D3 resulted in small amounts of product comigrating with natural lactone. It appears that 23(S),25-dihydroxyvitamin D3, but not 25,26-dihydroxyvitamin D3, is a natural precursor in ...
https://www.pnas.org/content/78/8/4805?ijkey=d08630811f2c2170b5d05479a34b1227d6a2e9b2&keytype2=tf_ipsecsha
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ASCENT: Androgen Independent Prostate Cancer Study of Calcitriol Enhancing Taxotere - Full Text View - ClinicalTrials.govASCENT: Androgen Independent Prostate Cancer Study of Calcitriol Enhancing Taxotere - Full Text View - ClinicalTrials.gov
DN-101 is an investigational drug that has not been approved by the U.S. Food and Drug Administration (FDA). It is a newly formulated pill that contains high amounts of calcitriol, a naturally occurring hormone and the biologically active form of vitamin D. Administration of DN-101 results in much higher blood levels of calcitriol than the body can produce from dietary vitamin D or vitamin D supplements. These higher levels of calcitriol are associated with anti-cancer effects in laboratory models of human cancer. Laboratory models also indicate that calcitriol has synergy with many commonly used chemotherapeutic agents used to treat cancer.. Calcitriol, at very low doses, is currently approved for use in patients with chronic kidney failure. DN-101 was specifically designed for cancer and contains 30 times the amount of calcitriol found in the calcitriol pill commercially available today. In order to take an amount of calcitriol equivalent to 1 DN-101 pill, cancer patients would need to swallow ...
https://clinicaltrials.gov/ct2/show/NCT00043576
Calcitriol QuickView - Correlation EngineCalcitriol QuickView - Correlation Engine
The mechanism of action of calcitriol in the treatment of psoriasis is accounted for by their antiproliferative activity for keratinocytes and their stimulation of epidermal cell differentiation. The anticarcinogenic activity of the active form of Calcitriol appears to be correlated with cellular vitamin D receptor (VDR) levels. Vitamin D receptors belong to the superfamily of steroid-hormone zinc-finger receptors. VDRs selectively bind 1,25-(OH)2-D3 and retinoic acid X receptor (RXR) to form a heterodimeric complex that interacts with specific DNA sequences known as vitamin D-responsive elements. VDRs are ligand-activated transcription factors. The receptors activate or repress the transcription of target genes upon binding their respective ligands. It is thought that the anticarcinogenic effect of Calcitriol is mediated via VDRs in cancer cells. The immunomodulatory activity of calcitriol is thought to be mediated by vitamin D receptors (VDRs) which are expressed constitutively in monocytes ...
https://accounts.public.ce.basespace.illumina.com/b/search/details/Calcitriol?type=compound
Calcitriol manufacturer,Calcitriol supplier & exporter|A.S.Joshi & Company IndiaCalcitriol manufacturer,Calcitriol supplier & exporter|A.S.Joshi & Company India
Calcitriol ,Calcitriol manufacturer,Calcitriol CAS No 32222-06-3,Calcitriol Molecular Formula C27H44O3,Calcitriol Synonyms (1R,3S)-5-[2-[(1R,3aR,7aS)-1-[(2R)-6-hydroxy-6-methyl-heptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H- inden-4-ylidene]ethylidene]-4-methylidene-cyclohexane-1,3-diol,Calcitriol Molecular weight 416.64 g/mol,Calcitriol manufacturing by A.S.Joshi & Company
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Effects of Cinacalcet and Concurrent Low-Dose Vitamin D on FGF23 Levels in ESRD | American Society of NephrologyEffects of Cinacalcet and Concurrent Low-Dose Vitamin D on FGF23 Levels in ESRD | American Society of Nephrology
Ongoing studies are attempting to determine the optimal combination of calcimimetics and calcitriol analogs for the treatment of SHPT. The ACHIEVE study recently compared the effects of Cinacalcet plus fixed low-dose calcitriol analogs with flexible doses of calcitriol analogs on PTH, Ca, and P levels (25). In this study, we used samples from ACHIEVE to perform a per-protocol analysis of the effects of treatment on FGF23, a factor associated with poor outcomes in ESRD (15). We found that the treatment regimen using Cinacalcet plus fixed low-dose calcitriol analogs results in a relative decrease in FGF23 levels compared with an approach using escalating doses of calcitriol analogs alone. This study is the first report of the disparate effects of different treatment strategies on FGF23 levels in HD patients.. The existence of complex interactions between treatment agents and mineral metabolic parameters make it difficult to ascribe the observed differences in FGF23 to a specific therapeutic ...
https://cjasn.asnjournals.org/content/5/1/110
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Effect of calcitriol on the production of T-cell-derived cytokines in psoriasisEffect of calcitriol on the production of T-cell-derived cytokines in psoriasis
If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Please Ask the Library, or send a letter to: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. You will be contacted as soon as possible. ...
http://dare.uva.nl/search?metis.record.id=137378
The in vitro evaluation of 25-hydroxyvitamin D<sub>3</sub> and 19-nor-1α,25- dihydroxyvitamin D<sub>2</sub> as therapeutic...The in vitro evaluation of 25-hydroxyvitamin D<sub>3</sub> and 19-nor-1α,25- dihydroxyvitamin D<sub>2</sub> as therapeutic...
TY - JOUR. T1 - The in vitro evaluation of 25-hydroxyvitamin D3 and 19-nor-1α,25- dihydroxyvitamin D2 as therapeutic agents for prostate cancer. AU - Chen, Tai C.. AU - Schwartz, Gary G.. AU - Burnstein, Kerry L.. AU - Lokeshwar, Bal L.. AU - Holick, Michael F.. PY - 2000/3/1. Y1 - 2000/3/1. N2 - Prostate cancer cells contain specific receptors [vitamin D receptors (VDRs)] for 1α,25-dihydroxyvitamin D3 (1α,25(OH)2D3), which is known to inhibit the proliferation and invasiveness of these cells. These findings support the use of 1α,25(OH)2D3 for prostate cancer therapy. However, because 1α,25(OH)2D3 can cause hypercalcemia, analogues of 1α,25(OH)2D3 that are less calcemic but that exhibit potent antiproliferative activity would be attractive as therapeutic agents. We investigated the effects of two different types of less calcemic vitamin D compounds, 25-hydroxyvitamin D3 [25(OH)D3] and 19-nor-1α,25-dihydroxyvitamin D2 [19-nor-1,25(OH)2D2], and compared their activity to 1α,25(OH)2D3 on ...
https://augusta.pure.elsevier.com/en/publications/the-in-vitro-evaluation-of-25-hydroxyvitamin-dsub3sub-and-19-nor-
Hormonally active agents in the environment: a state-of-the-art review : Reviews on Environmental HealthHormonally active agents in the environment: a state-of-the-art review : Reviews on Environmental Health
AbstractAfter the Second World War, infatuation with modern products has exponentially widened the spectrum of chemicals used. Some of them are capable of hijacking the endocrine system by blocking or imitating a hormone and are referred to as hormonally active chemicals or endocrine disruptors. These are chemicals that the body was not designed for evolutionarily and they are present in every matrix of the environment. We are living in a chemical world where the exposures are ubiquitous and take place in combinations that can interact with the endocrine system and some other metabolic activities in unexpected ways. The complexity of interaction of these compounds can be understood by the fact that they interfere with gene expression at extremely low levels, consequently harming an individual life form, its offspring or population. As the endocrine system plays a critical role in many biological or physiological functions, by interfering bodys endocrine system, endocrine disrupting compounds (EDCs)
https://www.degruyter.com/view/j/reveh.2016.31.issue-4/reveh-2016-0014/reveh-2016-0014.xml
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Calcitriol 0.5mcg Capsules - SummaryCalcitriol 0.5mcg Capsules - Summary
There is a close correlation between treatment with calcitriol and the development of hypercalcemia.. All other vitamin D compounds and their derivative, including proprietary compounds or foodstuffs which may be fortified with vitamin D, should be withheld during treatment with calcitriol.. An abrupt increase in calcium intake as a result of changes in diet (e.g. increased consumption of dairy products) or uncontrolled intake of calcium preparations may trigger hypercalcaemia. Patients and their families should be advised that strict adherence to the prescribed diet is mandatory and they should be instructed on how to recognise the symptoms of hypercalcaemia.. As soon as the serum calcium levels rise to 1 mg/100 ml (250 pmol/l) above normal (9-11 mg/100 ml, or 2250-2750 pmol/l), or serum creatinine rises to , 120 pmol/l, treatment with calcitriol should be stopped immediately until normocalcemia ensues.(see section 4.2). Immobilized patients, e.g. those who have undergone surgery, are ...
https://imedi.co.uk/calcitriol-0-5mcg-capsules/summary
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Calcitriol - DrugBankCalcitriol - DrugBank
Calcitriol or 1,25-dihydroxycholecalciferol (abbreviated 1,25-(OH)2-D3) is the active form of vitamin D found in the body (vitamin D3). Calcitriol is marketed under various trade names including Rocaltrol (Roche), Calcijex (Abbott) and Decostriol (Mibe, Jesalis). It is produced in the kidneys via 25-hydroxyvitamin D-1 α-hydroxylase by conversion from 25-hydroxycholecalciferol (calcidiol). This is stimulated by a decrease in serum calcium, phosphate (PO43−) and parathyroid hormone (PTH) levels. It regulates calcium levels by increasing the absorption of calcium and phosphate from the gastrointestinal tract, increasing calcium and phosphate reabsorption in the kidneys and inhibiting the release of PTH. Calcitriol is also commonly used as a medication in the treatment of hypocalcemia and osteoporosis.
https://www.drugbank.ca/drugs/DB00136
Calcitriol Receptors - Calcitriol Receptor Summary Report | CureHunterCalcitriol Receptors - Calcitriol Receptor Summary Report | CureHunter
Calcitriol Receptors: Proteins, usually found in the cytoplasm, that specifically bind calcitriol, migrate to the nucleus, and regulate transcription of specific segments of DNA with the participation of D receptor interacting proteins (called DRIP). Vitamin D is converted in the liver and kidney to calcitriol and ultimately acts through these receptors.
http://www.curehunter.com/public/keywordSummaryD018167-D3-Receptor--1-25-Dihydroxyvitamin.do
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Calcitriol will work only if you get the right amount of calcium from the foods you eat. If you get too much calcium from foods, you may experience serious side effects of calcitriol, and if you do not get enough calcium from foods, calcitriol will not control your condition. Your doctor will tell you which foods are good sources of these nutrients and how many servings you need each day. If you find it difficult to eat enough of these foods, tell your doctor. In that case, your doctor can prescribe or recommend a supplement.. If you are being treated with dialysis (process of cleaning the blood by passing it through a machine), your doctor may also prescribe a low-phosphate diet. Follow these directions carefully.. If you do not have kidney disease, you should drink plenty of fluids while taking calcitriol. If you have kidney disease, talk to your doctor about how much fluid you should drink each day.. ...
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Global Calcitriol (CAS 32222-06-3) Market 2017: By Manufacturers, Regions, Type and Application, Forecast to 2022 | BusinessGlobal Calcitriol (CAS 32222-06-3) Market 2017: By Manufacturers, Regions, Type and Application, Forecast to 2022 | Business
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http://beforeitsnews.com/business/2017/02/global-calcitriol-cas-32222-06-3-market-2017-by-manufacturers-regions-type-and-application-forecast-to-2022-3173139.html
Electromechanical effects of 1,25-dihydroxyvitamin D with antiatrial fibrillation activities<...Electromechanical effects of 1,25-dihydroxyvitamin D with antiatrial fibrillation activities<...
TY - JOUR. T1 - Electromechanical effects of 1,25-dihydroxyvitamin D with antiatrial fibrillation activities. AU - Hanafy, Dicky A.. AU - Chang, Shih Lin. AU - Lu, Yen Yu. AU - Chen, Yao Chang. AU - Kao, Yu Hsun. AU - Huang, Jen Hung. AU - Chen, Shih Ann. AU - Chen, Yi Jen. PY - 2014. Y1 - 2014. N2 - Electromechanical Effects of 1,25-Dihydroxyvitamin D on the LA Introduction Treatment with 1,25-dihydroxyvitamin D (1,25[OH]2D) has several cardiovascular benefits. 1,25[OH]2D has direct cellular effects, but its effects on the atrium are not clear. We evaluated the effects of 1,25[OH]2D on the atrial electrophysiology and atrial fibrillation (AF). Methods Conventional microelectrodes were used to record action potentials (APs) and contractility in isolated rabbit left atrium (LA) tissue preparations before and after the administration of 0.01, 0.1, and 1 nM 1,25[OH] 2D with and without rapid atrial pacing (RAP) and acetylcholine (5 mM)-induced AF. Surface ECG and intracardiac electrograms were ...
https://tmu.pure.elsevier.com/en/publications/electromechanical-effects-of-125-dihydroxyvitamin-d-with-antiatri
Total synthesis of 1α,25-dihydroxyvitamin D3 (calcitriol) through a Si-assisted allylic substitution - Chemical Communications ...Total synthesis of 1α,25-dihydroxyvitamin D3 (calcitriol) through a Si-assisted allylic substitution - Chemical Communications ...
Herein, we describe a versatile and efficient total synthesis of 1α,25-dihydroxyvitamin D3 (calcitriol). The synthetic strategy relies on an unprecedented Si-assisted SN2′-syn displacement of carbamates by cuprates to set the challenging pivotal quaternary methyl group at the fused-ring junction of the CD-tr
http://pubs.rsc.org/en/content/articlelanding/2017/cc/c7cc04690a/unauth
The Potential Role of Calcitriol Analogs in the Management of Breast Cancer.The Potential Role of Calcitriol Analogs in the Management of Breast Cancer.
Breast cancer is the second leading cause of cancer deaths among females and a leading cause of death of all middle age women in the United States. Epidemiologic evidence suggests a role for vitamin D deficiency in the development of breast cancer. Moreover, vitamin D receptors have been found in most breast cancers, and their presence appears to be a favorable prognostic sign. While much clinical focus has been given to the vitamin A related retinoids, little is known about the role for vitamin D in the development of breast cancer although vitamin D and its active metabolites and analogs represent a class of compounds which at the molecular and cellular level have strong similarities to the vitamin A metabolites and analogs. With the development of potent but non hypercalcemic analogs of vitamin D, the potential role of vitamin D in the etiology and treatment of breast cancer can now be tested both in vitro and in vivo. In the past decade, a number of tissues have been found to contain receptors for
http://oai.dtic.mil/oai/oai?verb=getRecord&metadataPrefix=html&identifier=ADA322065
Calcitriol - DogCalcitriol - Dog
Calcitriol (ergocalciferol, 1,25-dihydroxycholecalciferol, 1,25-dihydroxyvitamin D3) is a synthetic form of vitamin D[1]. Calcitriol causes increased calcium absorption from the gut. This product is used for treatment of hypocalcemia associated with rickets and hypoparathyroidism[2]. Regular monitoring of blood calcium is important to avoid development of hypercalcemia. Recommended dose in dogs is 25,000 - 50,000 U/day given orally[3]. ...
https://www.vetbook.org/wiki/dog/index.php?title=Calcitriol&printable=yes
Generation of inositol phosphates, diacylglycerol and calcium fluxes in myoblasts treated with 1,25-dihydroxyvitamin D3 |...Generation of inositol phosphates, diacylglycerol and calcium fluxes in myoblasts treated with 1,25-dihydroxyvitamin D3 |...
We have examined the effects of the seco-steroid hormone 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] on membrane phosphoinositide metabolism, protein kinase C (PKC) activation and influx of extracellular Ca2+ in chick-embryo muscle-cell (myoblast) cultures. At physiological concentrations, the hormone induces a rapid (15 s) and transient release of inositol triphosphate (InsP3) and diacylglycerol (DAG). InsP3 release is maximal at 60 s (80% above controls) and then declines. The effects of 1,25(OH)2D3 on InsP3 production exhibited specificity, as 25-hydroxy-vitamin D3 and 24,25-dihydroxy-vitamin D3 did not alter myoblast InsP3 levels. The stimulation of DAG is biphasic, with peaks at 60 s (+105%) and 5 min (+700%). The second phase of DAG release is not associated with changes in InsP3. 1,25(OH)2D3 induces a rapid (within 60 s) accumulation of InsP2, and its effect on InsP is delayed (120 s). The hormone rapidly activates myoblast PKC, with maximal translocation of activity from the cytosol to the ...
http://www.biochemj.org/content/289/3/675
Phase I study of weekly DN-101, a new formulation of calcitriol, in patients with cancer<...Phase I study of weekly DN-101, a new formulation of calcitriol, in patients with cancer<...
TY - JOUR. T1 - Phase I study of weekly DN-101, a new formulation of calcitriol, in patients with cancer. AU - Beer, Tomasz (Tom). AU - Javle, Milind M.. AU - Ryan, Christopher. AU - Garzotto, Mark. AU - Lam, Gilbert N.. AU - Wong, Alvin. AU - Henner, W. David. AU - Johnson, Candace S.. AU - Trump, Donald L.. PY - 2007/4. Y1 - 2007/4. N2 - Background: DN-101 is a new, high-dose, oral formulation of calcitriol under investigation for the treatment of cancer. We sought to evaluate the tolerability and pharmacokinetics (PK) of weekly doses of DN-101 in patients with advanced cancer. Methods: Patients who completed a previously reported single dose escalation study of DN-101 [Beer et al. (2005) Clin Cancer Res 11:7794-7799] were eligible for this continuation weekly dosing study. Cohorts of 3-10 patients were treated at doses of 15, 30, 45, 60, and 75 μg calcitriol. Once 45 μg was established as the maximum tolerated dose (MTD), this cohort was expanded to include 18 patients. Dose limiting ...
https://ohsu.pure.elsevier.com/en/publications/phase-i-study-of-weekly-dn-101-a-new-formulation-of-calcitriol-in-2
Calcitriol - Side Effects, Uses, Dosage, Overdose, Pregnancy, Alcohol | RxWikiCalcitriol - Side Effects, Uses, Dosage, Overdose, Pregnancy, Alcohol | RxWiki
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Sunshine hormone, vitamin D, may offer hope for treating liver fibrosis - Salk Institute for Biological StudiesSunshine hormone, vitamin D, may offer hope for treating liver fibrosis - Salk Institute for Biological Studies
Because there are currently no effective drugs for liver fibrosis, we believe our findings would open a new door for treatment, says senior author Ronald M. Evans, a professor in Salks Gene Expression Laboratory and lead researcher in the Institutes new Helmsley Center for Genomic Medicine. The Salk study focused on a star-shaped stellate cell in the liver that serves as a beacon for damage. When called into action, stellate cells produce fibrotic proteins in an attempt to heal an injury. Under chronic stress, however, localized fibrosis expands, eventually leading to cirrhosis, increased risk of liver cancer, and the need for a liver transplant in advanced cases. The Evans lab discovered a genetic switch through which vitamin D-related ligands such as calcitriol, a hormonally active form of the vitamin, can put the brakes on fibrosis. Preclinical results suggest the vitamin D brake is highly efficacious and led us to believe that the time is right to consider a trial in the context of ...
https://www.salk.edu/news-release/sunshine-hormone-vitamin-d-may-offer-hope-for-treating-liver-fibrosis/
C-terminal proteolysis of the avian 1,25-dihydroxyvitamin D<sub>3</sub>...C-terminal proteolysis of the avian 1,25-dihydroxyvitamin D<sub>3</sub>...
TY - JOUR. T1 - C-terminal proteolysis of the avian 1,25-dihydroxyvitamin D3 receptor. AU - Allegretto, Elizabeth A.. AU - Pike, J. Wesley. AU - Haussler, Mark R.. PY - 1987/8/31. Y1 - 1987/8/31. N2 - Exposure of the 60 kDa chick intestinal 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) receptor to carboxypeptidase A resulted in a time dependent decrease in receptor hormone-binding; after 2 h, there was no detectable macro-molecular-bound 1,25(OH)2[3H]D3. Upon DNA-cellulose chromatography of this preparation, a 56 kDa protein adsorbed to the column and eluted as a function of para-chloromercuribenzene sulfonate (a sulfhydryl blocking reagent). The 56 kDa fragment was detected by anti-receptor monoclonal antibodies via immunoblot technology. The 1,25(OH)2[3H]D3 eluted in the fall through fractions of the column. Thus, cleavage of up to 40 amino acids from the carboxy-terminus of the 1,25(OH)2D3 receptor results in a protein which no longer binds to hormone, but retains its capacity to interact with ...
https://arizona.pure.elsevier.com/en/publications/c-terminal-proteolysis-of-the-avian-125-dihydroxyvitamin-dsub3sub
Renal function during calcitriol therapy in chronic renal failureRenal function during calcitriol therapy in chronic renal failure
Some authors have reported that vitamin D treatment worsens renal function. We studied 10 patients with stable renal function, who were given calcitriol (0.5 micrograms/day) for a 4-month period. Creatinine and inulin clearance were performed at the beginning and at the end of the treatment. Althoug …
https://pubmed.ncbi.nlm.nih.gov/2311310/
calcitriol (vitamin D3) | PeaceHealthcalcitriol (vitamin D3) | PeaceHealth
Calcitriol is vitamin D3. Vitamin D is important for the absorption of calcium from the stomach and for the functioning of calcium in the body. Calcitriol is used to treat hyperparathyroidism (overactive parathyroid glands) and metabolic bone disease in people who have chronic kidney failure and are not receiving...
https://www.peacehealth.org/medical-topics/content/multum/d03126a1.html
Avet announces launch of Calcitriol soft gel capsules - Avet Pharmaceuticals Inc.Avet announces launch of Calcitriol soft gel capsules - Avet Pharmaceuticals Inc.
Avet Pharmaceuticals Inc. announced the immediate availability of Calcitriol soft gel capsules in 0.25 and 0.5 mcg strengths. This product is the AB rated generic equivalent to the synthetic Vitamin D drug Rocaltrol®* and adds to Avets robust portfolio of generic oral soft gel products. According to IMS data for the twelve-months ended April 2013, the U.S. market for Calcitriol approximated $60 million. *Rocaltrol is a registered trademark of Hoff-mann LaRoche-Validus.. Download Press Release. ...
http://avetpharma.com/Avet-announces-launch-of-calcitriol-soft-gel-capsules/
Mapping Variation in Cellular and Transcriptional Response to 1,25-Dihydroxyvitamin D3 in Peripheral Blood Mononuclear Cells.Mapping Variation in Cellular and Transcriptional Response to 1,25-Dihydroxyvitamin D3 in Peripheral Blood Mononuclear Cells.
The active hormonal form of vitamin D, 1,25-dihydroxyvitamin D (1,25D) is an important modulator of the immune system, inhibiting cellular proliferation and regulating transcription of immune response genes. In order to characterize the genetic basis of variation in the immunomodulatory effects of 1,25D, we mapped quantitative traits of 1,25D response at both the cellular and the transcriptional level. We carried out a genome-wide association scan of percent inhibition of cell proliferation (Imax) induced by 1,25D treatment of peripheral blood mononuclear cells from 88 healthy African-American individuals. Two genome-wide significant variants were identified: rs1893662 in a gene desert on chromosome 18 (p = 2.32 x 10−8) and rs6451692 on chromosome 5 (p = 2.55 x 10−8), which may influence the anti-proliferative activity of 1,25D by regulating the expression of nearby genes such as the chemokine gene, CCL28, and the translation initiation gene, PAIP1. We also identified 8 expression ...
http://www.tara.tcd.ie/handle/2262/77453
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Molecular cloning of a 1alpha,25-dihydroxyvitamin D3-inducible transcript (DDVit 1) in human blood monocytes - University of...Molecular cloning of a 1alpha,25-dihydroxyvitamin D3-inducible transcript (DDVit 1) in human blood monocytes - University of...
The differentiation and activation of monocytes (MO) and monocytic cells is modulated by 1alpha,25-dihydroxyvitamin D3 (Vitamin D3). In order to investigate early effects on the differentiation process of MO, we used the mRNA Differential Display technology to identify genes that are induced in freshly isolated human blood MO cultured for 4 hours with Vitamin D3. A cDNA fragment was isolated and Northern analysis confirmed a low expression of this cDNA at about 1,4 kb in MO which was increased by the addition of Vitamin D3. Using the rapid amplification of cDNA Ends (RACE)-PCR we got a transcript (DDVit 1) of a length of 1251 bp containing an open reading frame that encodes a putative 16,5 kD protein. Database search revealed an identity with a possible enterocyte differentiation promoting factor with a length of 1177 bp that has not been further characterized. Therefore DDVit 1 may be a differentiation promoting factor for the monocytic lineage. Further investigations will clarify the role of ...
https://epub.uni-regensburg.de/14314/
DIGITAL.CSIC: 1α,25-Dihydroxyvitamin D3 regulates the expression of Id1 and Id2 genes and the angiogenic phenotype of human...DIGITAL.CSIC: 1α,25-Dihydroxyvitamin D3 regulates the expression of Id1 and Id2 genes and the angiogenic phenotype of human...
1α,25-Dihydroxyvitamin D3 (1α,25(OH) 2D3) has antitumor activity in addition to its classical action on calcium metabolism and bone tissue biology. It is thought to regulate the expression of multiple target genes and thus modulate processes critical for tumor growth and metastases. Here we show that 1α,25(OH) 2D3 differentially regulates the expression of Id1 and Id2 genes, members of a family of transcriptional regulators of cell proliferation and differentiation. 1α,25(OH)2D3 induced epithelial differentiation in SW480-ADH human colon carcinoma cell line by promoting expression of the proteins implicated in adherent junction formation, including E-cadherin, and by inhibiting β-catenin transcriptional activity. 1α,25(OH)2D3 activated the human Id1 gene promoter and rapidly induced Id1 RNA and protein. Ectopic overexpression of Id1 was not sufficient to induce E-cadherin, which was critical for the morphological changes induced by 1α,25(OH)2D3 in SW480-ADH cells. Conversely, Id2 ...
https://digital.csic.es/handle/10261/81247?mode=full
The Effects of 1.25-dihydroxyvitamin D on HIF-1a Expression In Breast by Jessica HarrisThe Effects of 1.25-dihydroxyvitamin D on HIF-1a Expression In Breast by Jessica Harris
There is evidence that the active form of vitamin D, 1,25 dihydroxyvitamin D (1,25(OH)2D), may lead to reduced tumor formation by inhibiting vascularization, and thus feeding the tumor (1). Vascularization is controlled in part by the release of proteins which can be stimulated by low oxygen (hypoxia) to increase the transcriptional activity of hypoxia inducible factor 1α (HIF-1α) (2). HIF-1α controls the level of an important protein, vascular endothelial growth factor (VEGF), which stimulates vascularization (2). The level of HIF-1α protein level is regulated both transcriptionally and by protein stability through the activity of prolyl hydroxylase (PHD) (2). The purpose of this study is to determine if 1,25(OH)2D alters the mRNA expression of HIF-1α in untransformed (normal) cells and cells that contain the ErbB2 oncogene, a mutated gene commonly found in cancers.
https://docs.lib.purdue.edu/cfstheses/13/
Metabolic stability of 3-epi-1α,25-dihydroxyvitamin D3 over 1 α 25-dihydroxyvitamin D3: metabolism and molecular docking...Metabolic stability of 3-epi-1α,25-dihydroxyvitamin D3 over 1 α 25-dihydroxyvitamin D3: metabolism and molecular docking...
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https://www.sigmaaldrich.com/catalog/papers/23606409
The metabolism of 1,25-dihydroxyvitamin D3.<...The metabolism of 1,25-dihydroxyvitamin D3.<...
TY - JOUR. T1 - The metabolism of 1,25-dihydroxyvitamin D3.. AU - Kumar, Rajiv. PY - 1980/6. Y1 - 1980/6. UR - http://www.scopus.com/inward/record.url?scp=0019030105&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0019030105&partnerID=8YFLogxK. M3 - Article. C2 - 6894425. AN - SCOPUS:0019030105. VL - 1. SP - 258. EP - 267. JO - Endocrine Reviews. JF - Endocrine Reviews. SN - 0163-769X. IS - 3. ER - ...
https://mayoclinic.pure.elsevier.com/en/publications/the-metabolism-of-125-dihydroxyvitamin-d3
Defective binding and function of 1,25-dihydroxyvitamin D3 rec...Defective binding and function of 1,25-dihydroxyvitamin D3 rec...
Defective binding and function of 1,25-dihydroxyvitamin D3 receptors in peripheral mononuclear cells of patients with end-organ resistance to 1,25-dihydroxyvita
https://www.mysciencework.com/publication/show/defective-binding-and-function-of-1-25-dihydroxyvitamin-d3-receptors-in-peripheral-mononuclear-cells-of-patients-with-end-organ-resistance-to-1-25-dihydroxyvitamin-d
Calcitriol Oral Solution: Indications, Side Effects, Warnings - Drugs.comCalcitriol Oral Solution: Indications, Side Effects, Warnings - Drugs.com
Easy-to-read patient leaflet for Calcitriol Oral Solution. Includes indications, proper use, special instructions, precautions, and possible side effects.
https://www.drugs.com/cdi/calcitriol-oral-solution.html
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Effect of calcitriol on bone loss after cardiac or lung transplantation<...Effect of calcitriol on bone loss after cardiac or lung transplantation<...
TY - JOUR. T1 - Effect of calcitriol on bone loss after cardiac or lung transplantation. AU - Sambrook, Philip. AU - Henderson, N. Kathy. AU - Keogh, Anne. AU - MacDonald, Peter. AU - Glanville, Allan. AU - Spratt, Phillip. AU - Bergin, Peter. AU - Ebeling, Peter. AU - Eisman, John. PY - 2000/1/1. Y1 - 2000/1/1. N2 - Rapid bone loss after cardiac and lung transplantation results in an increased risk of osteoporotic fracture. This study examined the efficacy of treatment with calcitriol (1,25-dihydroxyvitamin D3) in preventing bone loss in patients undergoing cardiac or lung transplantation. In this 2-year double-blind, stratified study, 65 patients undergoing cardiac or single lung transplantation were randomly allocated to receive either placebo or calcitriol (0.5-0.75 μg/day), the latter for either 12 months or 24 months. All patients received 600 mg calcium/day. Bone mineral density (BMD) was measured every 6 months for 2 years by dual-energy X-ray absorptiometry. There was no significant ...
https://research.monash.edu/en/publications/effect-of-calcitriol-on-bone-loss-after-cardiac-or-lung-transplan
Treatment of secondary hyperparathyroidism with vitamin D derivatives and calcimimetics before and after start of dialysis :...Treatment of secondary hyperparathyroidism with vitamin D derivatives and calcimimetics before and after start of dialysis :...
Chronic renal failure is almost always associated with secondary uraemic hyperparathyroidism. Action should be taken as early as possible to avoid it or reduce its severity in patients with chronic kidney disease (CKD). Over the last decade, the most effective way of achieving this has been defined as therapy with active vitamin D derivatives. However, the so‐called non‐hypercalcaemic vitamin D derivatives, which are said to be superior, have not met our expectations so far. In contrast, calcimimetic agents, the new class of compounds that act specifically on the calcium‐sensing receptor, are very promising for the treatment and prevention of hyperparathyroidism. CKD is associated with disturbances in calcium, phosphate, and vitamin D metabolism that occur early in the course of renal disease. In most patients, these disturbances lead to secondary hyperparathyroidism and osteitis fibrosa or associated, more complex, skeletal lesions. Here, we focus on recent advances in the prevention ...
http://oxfordindex.oup.com/view/10.1093/ndt/17.suppl_11.20
Long term oral calcitriol in patients on chronic hemodialysis - ORA - Oxford University Research ArchiveLong term oral calcitriol in patients on chronic hemodialysis - ORA - Oxford University Research Archive
In a retrospective study, we have assessed the efficacy of oral calcitriol on the evolution of hyperparathyroid bone disease in patients on hemodialysis. 33 patients who had received calcitriol for at least one year and up to 7 years were carefully matched with controls for gender, years on
https://ora.ox.ac.uk/objects/uuid:11b5b65e-40e5-4674-9f94-0b8860e3cb71
The vitamin D receptor is a Wnt effector that controls hair follicle differentiation and specifies tumor type in adult...The vitamin D receptor is a Wnt effector that controls hair follicle differentiation and specifies tumor type in adult...
We have investigated how Wnt and vitamin D receptor signals regulate epidermal differentiation. Many epidermal genes induced by β-catenin, including the stem cell marker keratin 15, contain vitamin D response elements (VDREs) and several are induced independently of TCF/Lef. The VDR is required for β-catenin induced hair follicle formation in adult epidermis, and the vitamin D analog EB1089 synergises with β-catenin to stimulate hair differentiation. Human trichofolliculomas (hair follicle tumours) are characterized by high nuclear β-catenin and VDR, whereas infiltrative basal cell carcinomas (BCCs) have high β-catenin and low VDR levels. In mice, EB1089 prevents β-catenin induced trichofolliculomas, while in the absence of VDR β-catenin induces tumours resembling BCCs. We conclude that VDR is a TCF/Lef-independent transcriptional effector of the Wnt pathway and that vitamin D analogues have therapeutic potential in tumors with inappropriate activation of Wnt signalling.. ...
http://orca.cf.ac.uk/74656/
Plasma 1,25(OH)2 vitamin D measured by radioimmunoassay and cytosol radioreceptor assay in normal subjects and patients with...Plasma 1,25(OH)2 vitamin D measured by radioimmunoassay and cytosol radioreceptor assay in normal subjects and patients with...
Antibodies to 1 alpha, 25-dihydroxy vitamin D3 25-hemisuccinate linked to albumin were produced and an immunoassay for 1,25-dihydroxy vitamin D developed. Plasma 1,25-dihydroxy vitamin D concentrations were compared using an immunoassay and cytosol radioreceptor assay. Both assays gave comparable results but the immunoassay was more reproducible, slightly more sensitive and had a lower detection limit. Using the immunoassay the plasma 1,25-dihydroxy vitamin D was 110.5 pmol/l (S.D. 29.4) in normal subjects; there was no difference between males and premenopausal females. It was negatively related to plasma phosphate. In renal failure and primary hyperparathyroidism plasma 1,25(OH)2D was positively related to radiocalcium absorption. Following 1 and 2 microgram of 1,25-dihydroxy vitamin D3 given orally the peak plasma concentration occurs within 12 h.
https://www.semanticscholar.org/paper/Plasma-1%2C25
Letter by Zitterman et al Regarding Article, Calcium/Vitamin D Supplementation and Cardiovascular Events | CirculationLetter by Zitterman et al Regarding Article, Calcium/Vitamin D Supplementation and Cardiovascular Events | Circulation
To the Editor:. We read with interest the paper by Hsia and colleagues1 in which the authors demonstrated that a daily vitamin D supplement of 400 IU (10 μg) in combination with 1000 mg calcium has no beneficial effects on cardiovascular risk. In our opinion, the data interpretation is complicated by the lack of 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D (calcitriol) measurements. It may be that the vitamin D dose was too low to influence circulating calcitriol concentrations. It may also be that baseline 25-hydroxyvitamin D concentrations were already sufficient enough to produce adequate amounts of calcitriol. Calcitriol is the only vitamin D metabolite with known physiological actions. Experimental data demonstrate that calcitriol has important protective vascular effects such as suppression of renin activity, inhibition of vascular calcification, and reduction of thrombogenicity.2 Several retrospective studies already indicate that calcitriol and other active vitamin D analogs reduce ...
http://circ.ahajournals.org/content/116/3/e85.long
1,25-Dihydroxyvitamin D, Serum - Wyoming Medical Center1,25-Dihydroxyvitamin D, Serum - Wyoming Medical Center
Vitamin D is a generic designation for a group of fat-soluble, structurally similar sterols including ergocalciferol D2 from plants and cholecalciferol D3 from animals. Vitamin D in the body is derived from 2 sources: exogenous (dietary: D2 and D3) and endogenous (biosynthesis: D3). Endogenous D3 is produced in the skin from 7-dehydrocholesterol, under the influence of ultraviolet light. Both forms of vitamin D are of similar biologic activity.. Vitamin D is rapidly metabolized in the liver to form 25-hydroxy (OH) vitamin D. Additional hydroxylation of 25-OH vitamin D takes place in the kidney by 1-alpha hydroxylase, under the control of parathyroid hormone, to yield 1,25-dihydroxy vitamin D.. 1,25-Dihydroxy vitamin D is the most potent vitamin D metabolite. It stimulates calcium absorption in the intestine and its production is tightly regulated through concentrations of serum calcium, phosphorus, and parathyroid hormone.. 1,25-Dihydroxy vitamin D levels may be high in primary ...
http://wyomingmedicalcenter.testcatalog.org/show/DHVD
1 alpha,25-Dihydroxyvitamin D (calcitriol) inhibits the invasiveness of human prostate cancer cells. | Cancer Epidemiology,...1 alpha,25-Dihydroxyvitamin D (calcitriol) inhibits the invasiveness of human prostate cancer cells. | Cancer Epidemiology,...
1 alpha,25-Dihydroxyvitamin D (1,25 D; also know as calcitriol), the hormonal form of vitamin D, can inhibit the proliferation and promote the differentiation of human prostate adenocarcinoma cells. However, little is known about the effects of 1,25 D on the invasive ability of prostate cancer cells. We used an in vitro bioassay of cell invasion (Amgel assay) to examine the effects of 1,25 D and a noncalcemic vitamin D analogue, 1,25-dihydroxy-16-ene-23-yne-cholecalciferol (16-23-D3), on the invasiveness of three well-characterized human prostate carcinoma cell lines: DU 145, PC-3, and LNCaP. PC-3 and LNCaP cells were poorly invasive in Amgel and were hardly affected by treatment with 1,25 D or 16-23-D3 (, 3%). Conversely, DU 145 cells were highly invasive in Amgel, and their invasion was markedly inhibited by 1,25 D and 16-23-D3 (maximally 66 and 59.4% respectively). This effect was both dose-dependent, with maximal inhibition at 1 x 10(-7) M and 72 h. Significant inhibition of invasion was ...
http://cebp.aacrjournals.org/content/6/9/727.long
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Absorption Calcitriol is rapidly absorbed from the intestine. Peak serum concentrations (above basal values) were reached within 3 to 6 hours following oral administration of single doses of 0.25 to 1.0 mcg of Rocaltrol. Following a single oral dose of 0.5 mcg, mean serum concentrations of calcitriol rose from a baseline value of 40.0±4.4 (SD) pg/mL to 60.0±4.4 pg/mL at 2 hours, and declined to 53.0±6.9 at 4 hours, 50±7.0 at 8 hours, 44±4.6 at 12 hours, and 41.5±5.1 at 24 hours. Following multiple-dose administration, serum calcitriol levels reached steady-state within 7 days. Distribution Calcitriol is approximately 99.9% bound in blood. Calcitriol and other vitamin D metabolites are transported in blood, by an alpha-globulin vitamin D binding protein. There is evidence that maternal calcitriol may enter the fetal circulation. Calcitriol is transferred into human breast milk at low levels (ie, 2.2±0.1 pg/mL). Metabolism In vivo and in vitro studies indicate the presence of two pathways ...
http://internetpdfarticles.com/r/rocaltrol.us1.html
The Wnt antagonist DICKKOPF-1 gene is induced by 1α,25-dihydroxyvitamin D3 associated to the differentiation of human colon...The Wnt antagonist DICKKOPF-1 gene is induced by 1α,25-dihydroxyvitamin D3 associated to the differentiation of human colon...
The Wnt-β-catenin pathway is aberrantly activated in most colon cancers. DICKKOPF-1 (DKK-1) gene encodes an extracellular Wnt inhibitor that blocks the formation of signalling receptor complexes at the plasma membrane. We report that 1α,25-dihydroxyvitamin D3 [1,25(OH)2D3], the most active vitamin D metabolite, increases the level of DKK-1 RNA and protein in human SW480-ADH colon cancer cells. This effect is dose dependent, slow and depends on the presence of a transcription-competent nuclear vitamin D receptor (VDR). Accordingly, 1,25(OH)2D3 activates a 2300 bp fragment of the human DKK-1 gene promoter. Chromatin immunoprecipitation assays revealed that 1,25(OH)2D3 treatment induced a pattern of histone modifications which is compatible with transcriptionally active chromatin. DKK-1 is expressed at high level in colon cancer cell lines with a differentiated phenotype such as Caco-2 or HT-29. Exogenous expression of E-cadherin into SW480-ADH cells results in a strong adhesive phenotype and a ...
http://oxfordindex.oup.com/view/10.1093/carcin/bgm094
The dichotomy in the effects of 1,25 dihydroxyvitamin D<sub>3</sub> and 24,25-dihydroxyvitamin D<sub>3</sub> on bone γ...The dichotomy in the effects of 1,25 dihydroxyvitamin D<sub>3</sub> and 24,25-dihydroxyvitamin D<sub>3</sub> on bone γ...
TY - JOUR. T1 - The dichotomy in the effects of 1,25 dihydroxyvitamin D3 and 24,25-dihydroxyvitamin D3 on bone γ-carboxyglutamic acid-containing protein in serum and bone in vitamin D-deficient rats. AU - Wientroub, Shlomo. AU - Price, Paul A.. AU - Reddi, A Hari. PY - 1987/5. Y1 - 1987/5. N2 - Vitamin D-deficient, second generation, rachitic rats showed significant decrease in bone Gla protein (BGP) levels in circulation and in the skeleton. 1,25 dehydroxyvitamin D3 (1,25 (OH)2D3) exhibited the most potent influence on serum BGP levels in a dose-dependent manner. At a dose 25 ng/100 g body weight 1,25 (OH)2D3 showed a cumulative effect, i.e., the longer the treatment, the more circulating BGP was detected 24,25 dehydroxyvitamin D3 (24,25(OH)2D3) at the same doses did not show similar effect on the serum BGP levels, regardless of the serum calcium levels. Bone BGP levels assayed at various sites representing endochondral and intramenbranous ossification demonstrated an opposite pattern. ...
https://ucdavis.pure.elsevier.com/en/publications/the-dichotomy-in-the-effects-of-125-dihydroxyvitamin-dsub3sub-and
Lirias: Immunoregulation by 1,25-dihydroxyvitamin D3: basic conceptsLirias: Immunoregulation by 1,25-dihydroxyvitamin D3: basic concepts
1,25-Dihydroxyvitamin D(3) (1,25(OH)(2)D(3)), the biologically active metabolite of Vitamin D(3), not only regulates bone and calcium metabolism but also exerts other biological activities, including immunomodulation via the nuclear Vitamin D receptor expressed in antigen-presenting cells and activated T cells. This regulation is mediated through interference with nuclear transcription factors such as NF-AT and NF-kappaB or by direct interaction with Vitamin D responsive elements in the promoter regions of cytokine genes. Dendritic cells (DCs) are primary targets for the immunomodulatory activity of 1,25(OH)(2)D(3), as indicated by inhibited DC differentiation and maturation, leading to down-regulated expression of MHC-II, costimulatory molecules and IL-12. Moreover, 1,25(OH)(2)D(3) enhances IL-10 production and promotes DC apoptosis. Together, these effects of 1,25(OH)(2)D(3) inhibit DC-dependent T cell activation. Immunomodulation by 1,25(OH)(2)D(3) and its analogs in vivo has been ...
https://lirias.kuleuven.be/handle/123456789/22695
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In the first pilot trial with calcitriol, Walter et al. (5) reported no differences in fasting C-peptide, AUC C-peptide, and peak C-peptide after a mixed meal between treated and placebo groups at 9 and 18 months. A1C and insulin requirement were also similar between the groups. In the aforementioned study, no threshold of C-peptide level at study entry was defined. We designed a trial in which patients were younger at diagnosis, including also children, and should have had basal C-peptide levels at entry ,0.25 nmol/l so that a possible effect of calcitriol on disease progression could have been detected. We have shown that calcitriol does not affect residual β-cell function in such patients, even those of younger age. Similar to the German trial describing a mean C-peptide decrease of ∼40% at 18 months, in our study, decline of C-peptide after 24 months was 44.4% in the calcitriol group and 42.5% in the placebo group. These findings substantially confirm the data from combined studies ...
http://care.diabetesjournals.org/content/33/9/1962
Cancers | Free Full-Text | Gene Regulatory Scenarios of Primary 1,25-Dihydroxyvitamin D3 Target Genes in a Human Myeloid...Cancers | Free Full-Text | Gene Regulatory Scenarios of Primary 1,25-Dihydroxyvitamin D3 Target Genes in a Human Myeloid...
Genome- and transcriptome-wide data has significantly increased the amount of available information about primary 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) target genes in cancer cell models, such as human THP-1 myelomonocytic leukemia cells. In this study, we investigated the genes G0S2, CDKN1A and MYC as master examples of primary vitamin D receptor (VDR) targets being involved in the control of cellular proliferation. The chromosomal domains of G0S2 and CDKN1A are 140-170 kb in size and contain one and three VDR binding sites, respectively. This is rather compact compared to the MYC locus that is 15 times larger and accommodates four VDR binding sites. All eight VDR binding sites were studied by chromatin immunoprecipitation in THP-1 cells. Interestingly, the site closest to the transcription start site of the down-regulated MYC gene showed 1,25(OH)2D3-dependent reduction of VDR binding and is not associated with open chromatin. Four of the other seven VDR binding regions contain a typical DR3-type VDR
http://www.mdpi.com/2072-6694/5/4/1221
WildAlchemist: Vitamin D revealed to be miracle anti-cancer drug with astonishing chemical propertiesWildAlchemist: Vitamin D revealed to be miracle anti-cancer drug with astonishing chemical properties
A new study published this month finds that the hormonally active form of vitamin D, Calcitriol 1,25-dihydroxyvitamin D(3), inhibits the growth of many kinds of cancerous cells, including breast cancer, indicating that vitamin D3 can be useful in treating and even preventing a variety of cancers. Authors of the study said that caner cell growth is inhibited by anticancer actions including cell cycle arrest, promotion of apoptosis and inhibition of invasion, metastasis, and angiogenesis. Vitamin Ds anti-inflammatory properties and interference with estrogen synthesis further explains its anti-tumor properties. Two studies from 2007 used meta-analysis, which combines data from multiple reports, to find that therapeutic doses of vitamin D could prevent up to half of all cases of breast cancer, and two-thirds of all cases of colorectal cancer in the United States. The studies showed a direct correlation between blood levels of vitamin D and cancer. Those with the highest blood levels were found ...
http://wildalchemist.blogspot.com/2012/07/vitamin-d-revealed-to-be-miracle-anti.html
Cell membrane proteomic analysis identifies proteins differentially expressed in osteotropic human breast cancer cells. -...Cell membrane proteomic analysis identifies proteins differentially expressed in osteotropic human breast cancer cells. -...
en] Metastatic breast cancer cells are characterized by their high propensity to colonize the skeleton and form bone metastases, causing major morbidity and mortality. Identifying key proteins involved in the osteotropic phenotype would represent a major step toward the development of both new prognostic markers and new effective therapies. Cell surface proteins differentially expressed in cancer cells are preferred potential targets for antibody-based targeted therapies. In this study, using cell surface biotinylation and a mass spectrometric approach, we have compared the profile of accessible cell surface proteins between the human breast cancer cell line MDA-MB-231 and its highly osteotropic B02 subclone. This strategy allowed the identification of several proteins either up- or downregulated in the osteotropic cell line, and differential protein expressions were validated using antibody-based techniques. Class I HLAs were down-regulated in the bone metastatic variant, whereas ...
https://orbi.uliege.be/handle/2268/24060
Hypercalciuria due to combined growth hormone and calcitriol therapy in uremia: effects of growth hormone on mineral...Hypercalciuria due to combined growth hormone and calcitriol therapy in uremia: effects of growth hormone on mineral...
Hypercalciuria due to combined growth hormone and calcitriol therapy in uremia: effects of growth hormone on mineral homeostasis in 75% nephrectomized weanling rats.
https://scholars.duke.edu/display/pub701112
CUTANEOUS COMPOSITION COMPRISING VITAMIN D ANALOGUE AND A MIXTURE OF SOLVENT AND SURFACTANTS - Patent applicationCUTANEOUS COMPOSITION COMPRISING VITAMIN D ANALOGUE AND A MIXTURE OF SOLVENT AND SURFACTANTS - Patent application
0006] In the research leading to the present invention, it was surprisingly found that certain three-component surfactant-solvent mixtures of a type which self-emulsifies in the presence of an excess of water to form microemulsions are suitable for inclusion in topical compositions for application on skin. The mixtures also exhibit a good solubilization capacity in dissolving sparingly water-soluble active ingredients such as vitamin D derivatives and analogues. The compositions are easily spreadable, and therefore likely to improve patient compliance, and exhibit an adequate physical and chemical stability. Compositions according to the invention comprising a vitamin D derivative or analogue have surprisingly been found to lead to a very high activation of the target gene cathelicidin in the biological assay described in Example 7 below, suggesting that the active ingredient is internalized by the keratinocytes on which the compositions are applied and activates the vitamin D receptor to a ...
http://www.patentsencyclopedia.com/app/20120322776
Indian Patents. 247527:GEMINI VITAMIN D3 COMPOUNDIndian Patents. 247527:GEMINI VITAMIN D3 COMPOUND
and Thomasset M. (1990) Endocrinology 127:580-587). The bone-oriented assays include: 1) assessment of bone resorption as determined via the release of Ca2+ from bone in vivo (in animals fed a zero Ca2+diet) (Hibberd K.A. and Norman A.W. (1969) Biochem. Pharmacol 18:2347-2355; Hurwitz S. etal (1967)7. Nutr. 91:319-323), or from bone explants in vitro (Bouillon R. et al (1992) J. Biol Chem. 267:3044-3051), 2) measurement of serum osteocalcin levels [osteocalcin is an osteoblast-specific protein that after its synthesis is largely incorporated into the bone matrix, but partially released into the circulation (or tissue culture medium) and thus represents a good market of bone formation or turnover] (Bouillon R. et al (1992) Clin. Chem. 38:2055-2060), or 3) bone ash content (Norman A.W. and Wong R.G. (1972) J. Nutr. 102:1709-1718). Only one kidney-oriented assay has been employed. In this assay, urinary Ca2+ excretion is determined (Hartenbower D.L. et al (1977) Walter de Gruyter, Berlin pp ...
http://www.allindianpatents.com/patents/247527-gemini-vitamin-d3-compound
Vitamin D receptor expression in peripheral blood mononuclear cells is inversely associated with disease activity and...Vitamin D receptor expression in peripheral blood mononuclear cells is inversely associated with disease activity and...
PBMC VDR expression is inversely associated with disease activity and inflammation in SLE patients, and VDR downregulation is likely driven by inflammation.
https://pubmed.ncbi.nlm.nih.gov/31104216/?fbclid=IwAR2NWCVLr1Rb7YBmiFSZuTdchh2ewaEAeP-MJCEn2WVGF-hXdzJKWzIevvM
Publications | College of Veterinary MedicinePublications | College of Veterinary Medicine
Hostutler RA, DiBartola SP, Chew DJ, Nagode LA, Schenck PA, Rajala-Schultz PJ, Drost WT: Comparison of the effects of daily and intermittent-dose calcitriol on serum parathyroid hormone and ionized calcium concentrations in normal cats and cats with chronic renal failure. J Vet Intern Med 20(6): 1307-1313, 2006 ...
https://vet.osu.edu/publications-51
Calcifediol-loaded liposomes for local treatment of pulmonary bacterial infections. | LJMU Research OnlineCalcifediol-loaded liposomes for local treatment of pulmonary bacterial infections. | LJMU Research Online
The influence of vitamin D3 and its metabolites calcifediol (25(OH)D) and calcitriol on immune regulation and inflammation is well described, and raises the question of potential benefit against bacterial infections. In the current study, 25(OH)D was encapsulated in liposomes to enable aerosolisation, and tested for the ability to prevent pulmonary infection by Pseudomonas aeruginosa. Prepared 25(OH)D-loaded liposomes were nanosized and monodisperse, with a negative surface charge and a 25(OH)D entrapment efficiency of approximately 23%. Jet nebulisation of liposomes was seen to yield an aerosol suitable for tracheo-bronchial deposition. Interestingly, 25(OH)D in either liposomes or ethanolic solution had no effect on the release of the proinflammatory cytokine KC from Pseudomonas-infected murine epithelial cells (LA-4); treatment of infected, human bronchial 16-HBE cells with 25(OH)D liposomes however resulted in a significant reduction in bacterial survival. Together with the importance of ...
http://researchonline.ljmu.ac.uk/6620/
Nutrients | Free Full-Text | Molecular Link between Vitamin D and Cancer PreventionNutrients | Free Full-Text | Molecular Link between Vitamin D and Cancer Prevention
The metabolite of vitamin D, 1α,25-dihydroxyvitamin D3 (also known as calcitriol), is a biologically active molecule required to maintain the physiological functions of several target tissues in the human body from conception to adulthood. Its molecular mode of action ranges from immediate nongenomic responses to longer term mechanisms that exert persistent genomic effects. The genomic mechanisms of vitamin D action rely on cross talk between 1α,25-dihydroxyvitamin D3 signaling pathways and that of other growth factors or hormones that collectively regulate cell proliferation, differentiation and cell survival. In vitro and in vivo studies demonstrate a role for vitamin D (calcitriol) in modulating cellular growth and development. Vitamin D (calcitriol) acts as an antiproliferative agent in many tissues and significantly slows malignant cellular growth. Moreover, epidemiological studies have suggested that ultraviolet-B exposure can help reduce cancer risk and prevalence, indicating a potential role
https://www.mdpi.com/2072-6643/5/10/3993
Oral Paricalcitol May Have Similar Efficacy to Oral Calcitriol - Renal and Urology NewsOral Paricalcitol May Have Similar Efficacy to Oral Calcitriol - Renal and Urology News
OP appears to have similar efficacy and safety compared with oral calcitriol (OC) in dialysis patients with secondary hyperparathyroidism (SHPT).
http://www.renalandurologynews.com/renal-week-2010-secondary-hyperparathyroidism/oral-paricalcitol-may-have-similar-efficacy-to-oral-calcitriol/article/191341/
Maturation state determines the response of osteogenic cells to surface roughness and 1,25-dihydroxyvitamin D<sub>3<...Maturation state determines the response of osteogenic cells to surface roughness and 1,25-dihydroxyvitamin D<sub>3<...
TY - JOUR. T1 - Maturation state determines the response of osteogenic cells to surface roughness and 1,25-dihydroxyvitamin D3. AU - Lohmann, C. H.. AU - Bonewald, L. F.. AU - Sisk, M. A.. AU - Sylvia, V. L.. AU - Cochran, D. L.. AU - Dean, D. D.. AU - Boyan, Barbara D.. AU - Schwartz, Z.. PY - 2000/1/1. Y1 - 2000/1/1. N2 - In this study we assessed whether osteogenic cells respond in a differential manner to changes in surface roughness depending on their maturation state. Previous studies using MG63 osteoblast-like cells, hypothesized to be at a relatively immature maturation state, showed that proliferation was inhibited and differentiation (osteocalcin production) was stimulated by culture on titanium (Ti) surfaces of increasing roughness. This effect was further enhanced by 1,25-dihydroxyvitamin D3 [1,25(OH)2D3]. In the present study, we examined the response of three additional cell lines at three different maturation states: fetal rat calvarial (FRC) cells (a mixture of multipotent ...
https://indiana.pure.elsevier.com/en/publications/maturation-state-determines-the-response-of-osteogenic-cells-to-s
Dihydroxyvitamin D3, 1 α, 25-[26,27-3H]-, 5µCi (185kBq) | PerkinElmerDihydroxyvitamin D3, 1 α, 25-[26,27-3H]-, 5µCi (185kBq) | PerkinElmer
5 µCi quantities of 1 a, 25-[26, 27-3H]-Dihydroxyvitamin D3, are available for your research. Application of [3H] Dihydroxyvitamin D3 can be found in: appearance of the rat testicular receptor during development in steroid biochemistry, in determination as a major intermediate in 25-hydroxyvitamin D3-26,23-lactone formation, receptors in the choroid plexus and ependyma in cellular neuroscience, etc.. ...
http://www.perkinelmer.com/product/dihydroxyvitamin-d3-1alpha-25-26-27-3-net626005uc
Nuclear Receptor/Transcription Factor | DC ChemicalsNuclear Receptor/Transcription Factor | DC Chemicals
Maxacalcitol 22-Oxacalcitriol is a Vitamin D3 analog which is Non-calcemic as well as a VDR ligand. 22-Oxacalcitriol has been shown to decrease parathyroid hormone (PTH) mRNA expression in vitro. Additionally has been noted to exhibit similar effects to calcitriol in. ...
http://www.dcchemicals.com/products/nuclear_receptor_transcription_factor.html
Hypercalcemia, Hodgkins Disease, and Calcitriol | Annals of Internal Medicine | American College of PhysiciansHypercalcemia, Hodgkins Disease, and Calcitriol | Annals of Internal Medicine | American College of Physicians
To the editor: We read with interest the recent report by Breslau and associates (1). We have recently studied the case of a patient with Hodgkins disease with hypercalcemia and increased calcitriol levels.. A 51-year-old white man was admitted to St. Josephs Hospital and Medical Center with polyuria, polydyspia, and constipation. The only abnormal findings on physical examination were hard 1- to 2-cm left inguinal lymphadenopathy and a spleen tip palpable on deep inspiration. Laboratory data included serum calcium, 11.7 mg/dL; inorganic phosphorus, 2.1 mg/dL; creatinine, 2.9 mg/dL; albumin, 4.3 mg/dL; magnesium, 2.1 mg/dL; and alkaline phosphatase, 0.52 IU/L. Thyroid ...
http://annals.org/aim/article-abstract/698595/hypercalcemia-hodgkin-s-disease-calcitriol
Vitamin D-sensitive calcium signaling in depression (Homo sapiens) - WikiPathwaysVitamin D-sensitive calcium signaling in depression (Homo sapiens) - WikiPathways
Depression has been linked to (lack of) sunlight exposure and raised intracellular calcium levels. In this pathway, the role of the vitamin D pathway in calcium signaling in depression is shown. Active 1,25-dihydroxy-vitamin D3 is formed from 7-dehydrocholesterol by multiple conversion steps. It associates with RXR and VDR in the nucleus, which stimulates transcription of VDR target genes, resulting in lower intracellular calcium levels. Less sunlight exposure results in lower 1,25-dihydroxyvitamin D3 levels and therefore higher calcium levels ...
https://www.wikipathways.org/index.php?title=Pathway:WP4698&direction=next&oldid=106565
Can you overdose on calcitriol?Can you overdose on calcitriol?
Administration of Rocaltrol (calcitriol) to patients in excess of their daily requirements can cause hypercalcemia, hypercalciuria, and hyperphosphatemia. Since calcitriol is a derivative of vitamin D, the signs and symptoms of overdose are the same as for an overdose of vitamin D (see ADVERSE REACTIONS).
https://findanyanswer.com/can-you-overdose-on-calcitriol
BeatingCancerCenter - The Di Bella Method - Role of vitamin D receptor in the antiproliferative effects of calcitriol in tumor...BeatingCancerCenter - The Di Bella Method - Role of vitamin D receptor in the antiproliferative effects of calcitriol in tumor...
Private MD Health News - Vitamin D Deficiency-Diagnosis and Treatment NewsPrivate MD Health News - Vitamin D Deficiency-Diagnosis and Treatment News
It may be more important than ever for older people to get enough vitamin D in their systems, either from the sun or through nutritional supplements. According to a new study, their lives may depend on it.... Full Story ...
http://www.privatemdlabs.com/catnews.php?catid=438026436&yr=2009&m=09
1.25 dihydroxyvitamin D3 receptor exist of osteoclast precursors<...1.25 dihydroxyvitamin D3 receptor exist of osteoclast precursors<...
TY - JOUR. T1 - 1.25 dihydroxyvitamin D3 receptor exist of osteoclast precursors. AU - Kamioka, Hiroshi. PY - 1991. Y1 - 1991. M3 - Article. VL - 28. SP - 185. EP - 189. JO - Dentitry in Japan. JF - Dentitry in Japan. ER - ...
https://okayama.pure.elsevier.com/en/publications/125-dihydroxyvitamin-d3-receptor-exist-of-osteoclast-precursors
Plus itPlus it
Calcitriol Inhibits the Th1 and Promotes the Th2 Profile in Mice with TNBS Colitis. Th1 lymphocyte differentiation is known to be based on a sequence of cell-intrinsic and exogenous, DC-derived factors, including augmentation of the transcription factor T-bet following activation by DC-derived IL-12. The observed reduction of the Th1 mediators, especially after treatment with the combination of dexamethasone and calcitriol, was further confirmed by immunoblot analysis of the T-bet. The combined administration of calcitriol and dexamethasone led to a significant reduction of T-bet protein expression compared with dexamethasone monotherapy (P , 0.001 versus dexamethasone, Fig. 3, A and B). As a next step to assess a possible role of calcitriol and dexamethasone in promoting the Th2 subset, we analyzed IL-4 production as well as the relevant Th2 lineage commitment factor GATA3. Calcitriol significantly up-regulated IL-4, whereas dexamethasone alone did not cause any significant change in IL-4 ...
http://jpet.aspetjournals.org/content/324/1/23
1,25-Dihydroxyvitamin D3 prevented allergic asthma in a rat model...: Ingenta Connect1,25-Dihydroxyvitamin D3 prevented allergic asthma in a rat model...: Ingenta Connect
The active form of 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] regulates calcium homeostasis, immunity, and other physiological processes while its effect in T-helper lymphocyte type 2 models is not very clear. The prevention effect of 1,25(OH)2D3 for allergic asthma in a rat asthma model was investigated. Healthy Wistar rats were randomly divided into four groups: control group, asthma group, drug prevention group, and treatment group. Asthma was induced in rats by sensitization and challenges with ovalbumin (OVA). The drug prevention group and treatment group were given 1,25(OH)2D3 or vitamin D3 on different schedules. The effects of 1,25(OH)2D3 on the development of asthma were analyzed. The airway hyperresponsiveness, the inflammatory cell infiltration in bronchoalveolar lavage (BAL) fluid, and histological changes of lung cells were examined. Nitric oxide production and the expression and activity of induced nitric oxide synthase (iNOS) in the lungs were examined also. Our study showed that ...
https://www.ingentaconnect.com/content/ocean/aap/2008/00000029/00000003/art00005?token=004b16736a406839412f415d4874255f45234a5f2441516f253048296a7c2849266d656c785
1α,25-dihydroxyvitamin D3 promotes osteogenic activity and downregulates proinflammatory cytokine expression in human...1α,25-dihydroxyvitamin D3 promotes osteogenic activity and downregulates proinflammatory cytokine expression in human...
The aim of this study was to assess the impact of 1α,25-dihydroxyvitamin D3 (vitamin D3) on osteogenic and inflammatory properties of human periodontal ligament (PDL) cells and investigate underlying mechanisms ...
https://portal.research.lu.se/portal/sv/publications/125dihydroxyvitamin-d3-promotes-osteogenic-activity-and-downregulates-proinflammatory-cytokine-expression-in-human-periodontal-ligament-cells
clinical Significance of the New Vitamin B 12 and Intrinsic Factor Research]. - Semantic Scholarclinical Significance of the New Vitamin B 12 and Intrinsic Factor Research]. - Semantic Scholar
Semantic Scholar extracted view of [clinical Significance of the New Vitamin B 12 and Intrinsic Factor Research]. by Konrad-Felix Krentz
https://www.semanticscholar.org/paper/clinical-Significance-of-the-New-Vitamin-B-12-and-Krentz/f3dc506b785c88d167a342cc1869b0f231b7eb7b
0.25 mcg of calcitriol is eequivalent to how many i.u. of cholecalciferol?0.25 mcg of calcitriol is eequivalent to how many i.u. of cholecalciferol?
1 Answer - Posted in: calcitriol, cholecalciferol - Answer: No - the doses are not the same. One IU of Vitamin D (Cholecalciferol) ...
https://www.drugs.com/answers/0-25-mcg-calcitriol-eequivalent-many-787541.html
Hall of Record: May 2008Hall of Record: May 2008
Hayes CE, Cantorna MT, DeLuca HF. Department of Biochemistry, University of Wisconsin-Madison 53706, USA.. Recently, it has been clearly demonstrated that exogenous 1,25-dihydroxyvitamin D3, the hormonal form of vitamin D3, can completely prevent experimental autoimmune encephalomyelitis (EAE), a widely accepted mouse model of human multiple sclerosis (MS). This finding has focused attention on the possible relationship of this disease to vitamin D. Although genetic traits certainly contribute to MS susceptibility, an environmental factor is also clearly involved. It is our hypothesis that one crucial environmental factor is the degree of sunlight exposure catalyzing the production of vitamin D3 in skin, and, further, that the hormonal form of vitamin D3 is a selective immune system regulator inhibiting this autoimmune disease. Thus, under low-sunlight conditions, insufficient vitamin D3 is produced, limiting production of 1,25-dihydroxyvitamin D3, providing a risk for MS. Although the evidence ...
http://hallofrecord.blogspot.com/2008/05/
Patent US4973584 - Novel 1α-hydroxyvitamin D2 epimer and derivatives - Google PatentsPatent US4973584 - Novel 1α-hydroxyvitamin D2 epimer and derivatives - Google Patents
The invention provides a new vitamin D2 compound, 1α-hydroxy-24-epi-vitamin D2 and certain hydroxy-protected derivatives thereof. The new compound exhibits a distinctive activity pattern comprising high potency in stimulating intestinal calcium transport and little or no activity in inducing bone calcium mobilization or the differentiation of undifferentiated cells in culture, thereby evincing utility in the treatment of diseases characterized by loss of bone mass.
http://www.google.com.au/patents/US4973584
VECTICAL OINTMENT (Calcitriol) dosage, indication, interactions, side effects | EMPR - Renal and Urology NewsVECTICAL OINTMENT (Calcitriol) dosage, indication, interactions, side effects | EMPR - Renal and Urology News
VECTICAL OINTMENT (Calcitriol) drug information & product resources from MPR including dosage information, educational materials, & patient assistance.
http://www.renalandurologynews.com/vectical-ointment/drug/3299/
Drug - Denscal 0.25mcg / 500mg / 45mcg / 22.5mg - 10 Capsule (Calcitriol) Price List or Cost of Medication | MedindiaDrug - Denscal 0.25mcg / 500mg / 45mcg / 22.5mg - 10 Capsule (Calcitriol) Price List or Cost of Medication | Medindia
Denscal 0.25mcg / 500mg / 45mcg / 22.5mg - 10 Capsule (Calcitriol) drug information. Find its price or cost, dose, when to use, how to use, side effects, adverse effects, substitutes. It is manufactured by Future pharma Pvt. Ltd.
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Buy online generic Rocaltrol (Calcitriol) / Diabetes / PrescriptionBuy online generic Rocaltrol (Calcitriol) / Diabetes / Prescription
Buy Rocaltrol (Calcitriol) online without prescription on discount prices. Cheap online pharmacy: Diabetes generic drugs and prescription medications.
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AnatomyDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesTechnology, Industry, AgricultureGeographicals
CalcitriolReceptors, CalcitriolCalcium Channel AgonistsHyperparathyroidism, SecondaryParathyroid HormoneErgocalciferolsVitaminsParathyroid GlandsHypercalcemiaPhosphorusVitamin DHypocalcemiaCalciumRenal OsteodystrophyUremia25-Hydroxyvitamin D3 1-alpha-HydroxylaseHyperparathyroidismSteroid HydroxylasesCalcifediolPacific StatesVitamin D Response ElementPhosphatesCholecalciferolHypoparathyroidismOsteomalaciaRenal DialysisParathyroidectomyPhosphorus, DietaryBone Density Conservation AgentsRicketsHypophosphatemia, FamilialHypophosphatemiaCalcium CarbonateBone and BonesAstemizoleSulfadimethoxineOsteocalcinAlkaline PhosphataseFamilial Hypophosphatemic RicketsAdministration, OralKidney Failure, ChronicS100 Calcium Binding Protein GCholestanetriol 26-MonooxygenaseReceptors, Calcium-SensingIdahoVitamin D DeficiencyHydroxyprostaglandin Dehydrogenases25-Hydroxyvitamin D 2HydroxycholecalciferolsDihydroxycholecalciferolsPulse Therapy, DrugProstatic NeoplasmsDose-Response Relationship, DrugFibroblast Growth FactorsCalcium GluconatePhosphorus Metabolism DisordersCalbindinsEtidronic AcidKidneys, ArtificialInjections, IntravenousAnnexin A6Calcium, DietaryBone ResorptionNephrectomyPharmaceutical VehiclesDrug SynergismInjections, IntralesionalDexamethasoneAlendronateRenal Insufficiency, ChronicCalcimimetic Agents
AnatomyDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesTechnology, Industry, AgricultureGeographicals
CalcitriolReceptors, CalcitriolCalcium Channel AgonistsHyperparathyroidism, SecondaryParathyroid HormoneErgocalciferolsVitaminsParathyroid GlandsHypercalcemiaPhosphorusVitamin DHypocalcemiaCalciumRenal OsteodystrophyUremia25-Hydroxyvitamin D3 1-alpha-HydroxylaseHyperparathyroidismSteroid HydroxylasesCalcifediolPacific StatesVitamin D Response ElementPhosphatesCholecalciferolHypoparathyroidismOsteomalaciaRenal DialysisParathyroidectomyPhosphorus, DietaryBone Density Conservation AgentsRicketsHypophosphatemia, FamilialHypophosphatemiaCalcium CarbonateBone and BonesAstemizoleSulfadimethoxineOsteocalcinAlkaline PhosphataseFamilial Hypophosphatemic RicketsAdministration, OralKidney Failure, ChronicS100 Calcium Binding Protein GCholestanetriol 26-MonooxygenaseReceptors, Calcium-SensingIdahoVitamin D DeficiencyHydroxyprostaglandin Dehydrogenases25-Hydroxyvitamin D 2HydroxycholecalciferolsDihydroxycholecalciferolsPulse Therapy, DrugProstatic NeoplasmsDose-Response Relationship, DrugFibroblast Growth FactorsCalcium GluconatePhosphorus Metabolism DisordersCalbindinsEtidronic AcidKidneys, ArtificialInjections, IntravenousAnnexin A6Calcium, DietaryBone ResorptionNephrectomyPharmaceutical VehiclesDrug SynergismInjections, IntralesionalDexamethasoneAlendronateRenal Insufficiency, ChronicCalcimimetic Agents

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