Calcitriol
The physiologically active form of vitamin D. It is formed primarily in the kidney by enzymatic hydroxylation of 25-hydroxycholecalciferol (CALCIFEDIOL). Its production is stimulated by low blood calcium levels and parathyroid hormone. Calcitriol increases intestinal absorption of calcium and phosphorus, and in concert with parathyroid hormone increases bone resorption.
Receptors, Calcitriol
Proteins, usually found in the cytoplasm, that specifically bind calcitriol, migrate to the nucleus, and regulate transcription of specific segments of DNA with the participation of D receptor interacting proteins (called DRIP). Vitamin D is converted in the liver and kidney to calcitriol and ultimately acts through these receptors.
Calcium Channel Agonists
Agents that increase calcium influx into calcium channels of excitable tissues. This causes vasoconstriction in VASCULAR SMOOTH MUSCLE and/or CARDIAC MUSCLE cells as well as stimulation of insulin release from pancreatic islets. Therefore, tissue-selective calcium agonists have the potential to combat cardiac failure and endocrinological disorders. They have been used primarily in experimental studies in cell and tissue culture.
Hyperparathyroidism, Secondary
Parathyroid Hormone
A polypeptide hormone (84 amino acid residues) secreted by the PARATHYROID GLANDS which performs the essential role of maintaining intracellular CALCIUM levels in the body. Parathyroid hormone increases intracellular calcium by promoting the release of CALCIUM from BONE, increases the intestinal absorption of calcium, increases the renal tubular reabsorption of calcium, and increases the renal excretion of phosphates.
Ergocalciferols
Vitamins
Parathyroid Glands
Phosphorus
Vitamin D
A vitamin that includes both CHOLECALCIFEROLS and ERGOCALCIFEROLS, which have the common effect of preventing or curing RICKETS in animals. It can also be viewed as a hormone since it can be formed in SKIN by action of ULTRAVIOLET RAYS upon the precursors, 7-dehydrocholesterol and ERGOSTEROL, and acts on VITAMIN D RECEPTORS to regulate CALCIUM in opposition to PARATHYROID HORMONE.
Hypocalcemia
Calcium
A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.
Renal Osteodystrophy
Uremia
A clinical syndrome associated with the retention of renal waste products or uremic toxins in the blood. It is usually the result of RENAL INSUFFICIENCY. Most uremic toxins are end products of protein or nitrogen CATABOLISM, such as UREA or CREATININE. Severe uremia can lead to multiple organ dysfunctions with a constellation of symptoms.
25-Hydroxyvitamin D3 1-alpha-Hydroxylase
A mitochondrial cytochrome P450 enzyme that catalyzes the 1-alpha-hydroxylation of 25-hydroxyvitamin D3 (also known as 25-hydroxycholecalciferol) in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP27B1 gene, converts 25-hydroxyvitamin D3 to 1-alpha,25-dihydroxyvitamin D3 which is the active form of VITAMIN D in regulating bone growth and calcium metabolism. This enzyme is also active on plant 25-hydroxyvitamin D2 (ergocalciferol).
Hyperparathyroidism
A condition of abnormally elevated output of PARATHYROID HORMONE (or PTH) triggering responses that increase blood CALCIUM. It is characterized by HYPERCALCEMIA and BONE RESORPTION, eventually leading to bone diseases. PRIMARY HYPERPARATHYROIDISM is caused by parathyroid HYPERPLASIA or PARATHYROID NEOPLASMS. SECONDARY HYPERPARATHYROIDISM is increased PTH secretion in response to HYPOCALCEMIA, usually caused by chronic KIDNEY DISEASES.
Steroid Hydroxylases
Calcifediol
Pacific States
Vitamin D Response Element
Cholecalciferol
Hypoparathyroidism
A condition caused by a deficiency of PARATHYROID HORMONE (or PTH). It is characterized by HYPOCALCEMIA and hyperphosphatemia. Hypocalcemia leads to TETANY. The acquired form is due to removal or injuries to the PARATHYROID GLANDS. The congenital form is due to mutations of genes, such as TBX1; (see DIGEORGE SYNDROME); CASR encoding CALCIUM-SENSING RECEPTOR; or PTH encoding parathyroid hormone.
Osteomalacia
Renal Dialysis
Phosphorus, Dietary
Phosphorus used in foods or obtained from food. This element is a major intracellular component which plays an important role in many biochemical pathways relating to normal physiological functions. High concentrations of dietary phosphorus can cause nephrocalcinosis which is associated with impaired kidney function. Low concentrations of dietary phosphorus cause an increase in calcitriol in the blood and osteoporosis.
Bone Density Conservation Agents
Rickets
Disorders caused by interruption of BONE MINERALIZATION manifesting as OSTEOMALACIA in adults and characteristic deformities in infancy and childhood due to disturbances in normal BONE FORMATION. The mineralization process may be interrupted by disruption of VITAMIN D; PHOSPHORUS; or CALCIUM homeostasis, resulting from dietary deficiencies, or acquired, or inherited metabolic, or hormonal disturbances.
Hypophosphatemia, Familial
An inherited condition of abnormally low serum levels of PHOSPHATES (below 1 mg/liter) which can occur in a number of genetic diseases with defective reabsorption of inorganic phosphorus by the PROXIMAL RENAL TUBULES. This leads to phosphaturia, HYPOPHOSPHATEMIA, and disturbances of cellular and organ functions such as those in X-LINKED HYPOPHOSPHATEMIC RICKETS; OSTEOMALACIA; and FANCONI SYNDROME.
Calcium Carbonate
Bone and Bones
Astemizole
Osteocalcin
Vitamin K-dependent calcium-binding protein synthesized by OSTEOBLASTS and found primarily in BONES. Serum osteocalcin measurements provide a noninvasive specific marker of bone metabolism. The protein contains three residues of the amino acid gamma-carboxyglutamic acid (Gla), which, in the presence of CALCIUM, promotes binding to HYDROXYAPATITE and subsequent accumulation in BONE MATRIX.
Alkaline Phosphatase
Familial Hypophosphatemic Rickets
Kidney Failure, Chronic
The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION.
S100 Calcium Binding Protein G
A calbindin protein found in many mammalian tissues, including the UTERUS, PLACENTA, BONE, PITUITARY GLAND, and KIDNEYS. In intestinal ENTEROCYTES it mediates intracellular calcium transport from apical to basolateral membranes via calcium binding at two EF-HAND MOTIFS. Expression is regulated in some tissues by VITAMIN D.
Cholestanetriol 26-Monooxygenase
Receptors, Calcium-Sensing
A class of G-protein-coupled receptors that react to varying extracellular CALCIUM levels. Calcium-sensing receptors in the PARATHYROID GLANDS play an important role in the maintenance of calcium HOMEOSTASIS by regulating the release of PARATHYROID HORMONE. They differ from INTRACELLULAR CALCIUM-SENSING PROTEINS which sense intracellular calcium levels.
Vitamin D Deficiency
A nutritional condition produced by a deficiency of VITAMIN D in the diet, insufficient production of vitamin D in the skin, inadequate absorption of vitamin D from the diet, or abnormal conversion of vitamin D to its bioactive metabolites. It is manifested clinically as RICKETS in children and OSTEOMALACIA in adults. (From Cecil Textbook of Medicine, 19th ed, p1406)
Hydroxyprostaglandin Dehydrogenases
25-Hydroxyvitamin D 2
Hydroxycholecalciferols
Dose-Response Relationship, Drug
Fibroblast Growth Factors
A family of small polypeptide growth factors that share several common features including a strong affinity for HEPARIN, and a central barrel-shaped core region of 140 amino acids that is highly homologous between family members. Although originally studied as proteins that stimulate the growth of fibroblasts this distinction is no longer a requirement for membership in the fibroblast growth factor family.
Calcium Gluconate
Phosphorus Metabolism Disorders
Calbindins
Etidronic Acid
Kidneys, Artificial
Annexin A6
Calcium, Dietary
Pharmaceutical Vehicles
Alendronate
Renal Insufficiency, Chronic
Conditions in which the KIDNEYS perform below the normal level for more than three months. Chronic kidney insufficiency is classified by five stages according to the decline in GLOMERULAR FILTRATION RATE and the degree of kidney damage (as measured by the level of PROTEINURIA). The most severe form is the end-stage renal disease (CHRONIC KIDNEY FAILURE). (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002)
Calcimimetic Agents
Vitamin D regulates human ectocervical epithelial cell proliferation and insulin-like growth factor-binding protein-3 level. (1/2474)
The differentiation status of the cervical epithelial cell has an important influence on responsiveness to estrogens and progestins. Several agents, including glucocorticoids and retinoids, are known to influence cervical cell differentiation. However, the effects of vitamin D have not been examined. Vitamin D is known to regulate cell proliferation and gene expression in a variety of epithelial cells. In the present study we investigated the ability of 1alpha25-dihydroxyvitamin D3 (D3) to regulate cell proliferation and expression of insulin-like growth factor-binding protein-3 (IGFBP-3) in human ectocervical epithelial cells. ECE16-1, a non-tumorigenic cervical cell line, was growth inhibited by D3 with maximal inhibition at 1000 nM. IGFBP-3 levels increased in parallel with the growth inhibition. IGFBP-3 levels were half-maximally increased at approximately 10-100 nM and maximally increased (10- to 30-fold) at 1000 nM D3. These studies show that vitamin D regulates cervical epithelial cell gene regulation and cell proliferation and that IGFBP-3 may be an in vivo marker of vitamin D action in the cervix. (+info)22-oxacalcitriol suppresses secondary hyperparathyroidism without inducing low bone turnover in dogs with renal failure. (2/2474)
BACKGROUND: Calcitriol therapy suppresses serum levels of parathyroid hormone (PTH) in patients with renal failure but has several drawbacks, including hypercalcemia and/or marked suppression of bone turnover, which may lead to adynamic bone disease. A new vitamin D analogue, 22-oxacalcitriol (OCT), has been shown to have promising characteristics. This study was undertaken to determine the effects of OCT on serum PTH levels and bone turnover in states of normal or impaired renal function. METHODS: Sixty dogs were either nephrectomized (Nx, N = 38) or sham-operated (Sham, N = 22). The animals received supplemental phosphate to enhance PTH secretion. Fourteen weeks after the start of phosphate supplementation, half of the Nx and Sham dogs received doses of OCT (three times per week); the other half were given vehicle for 60 weeks. Thereafter, the treatment modalities for a subset of animals were crossed over for an additional eight months. Biochemical and hormonal indices of calcium and bone metabolism were measured throughout the study, and bone biopsies were done at baseline, 60 weeks after OCT or vehicle treatment, and at the end of the crossover period. RESULTS: In Nx dogs, OCT significantly decreased serum PTH levels soon after the induction of renal insufficiency. In long-standing secondary hyperparathyroidism, OCT (0.03 microg/kg) stabilized serum PTH levels during the first months. Serum PTH levels rose thereafter, but the rise was less pronounced compared with baseline than the rise seen in Nx control. These effects were accompanied by episodes of hypercalcemia and hyperphosphatemia. In animals with normal renal function, OCT induced a transient decrease in serum PTH levels at a dose of 0.1 microg/kg, which was not sustained with lowering of the doses. In Nx dogs, OCT reversed abnormal bone formation, such as woven osteoid and fibrosis, but did not significantly alter the level of bone turnover. In addition, OCT improved mineralization lag time, (that is, the rate at which osteoid mineralizes) in both Nx and Sham dogs. CONCLUSIONS: These results indicate that even though OCT does not completely prevent the occurrence of hypercalcemia in experimental dogs with renal insufficiency, it may be of use in the management of secondary hyperparathyroidism because it does not induce low bone turnover and, therefore, does not increase the risk of adynamic bone disease. (+info)Serum levels of 1,25-dihydroxyvitamin D, 24,25-dihydroxyvitamin D, and 25-hydroxyvitamin D in nondialyzed patients with chronic renal failure. (3/2474)
BACKGROUND: In patients with chronic renal failure (CRF), abnormalities in vitamin D metabolism are known to be present, and several factors could contribute to the abnormalities. METHODS: We measured serum levels of three vitamin D metabolites, 1,25(OH)2D, 24, 25(OH)2D and 25(OH)D, and analyzed factors affecting their levels in 76 nondialyzed patients with CRF (serum creatinine> 1.6 and < 9.0 mg/dl), 37 of whom had diabetes mellitus (DM-CRF) and 39 of whom were nondiabetic (nonDM-CRF). RESULTS: Serum levels of 1,25(OH)2D were positively correlated with estimated creatinine clearance (CCr; r = 0.429; P < 0.0001), and levels of 24,25(OH)2D were weakly correlated with CCr (r = 0.252, P < 0.05); no correlation was noted for 25(OH)D. Serum levels of all three vitamin D metabolites were significantly and positively correlated with serum albumin. Although there were no significant differences in age, sex, estimated CCr, calcium and phosphate between DM-CRF and nonDM-CRF, all three vitamin D metabolites were significantly lower in DM-CRF than in nonDM-CRF. To analyze factors influencing vitamin D metabolite levels, we performed multiple regression analyses. Serum 25(OH)D levels were significantly and independently associated with serum albumin, presence of DM and serum phosphate (R2 = 0.599; P < 0.0001). 24,25(OH)2D levels were significantly and strongly associated with 25(OH)D (beta = 0.772; R2 = 0.446; P < 0.0001). Serum 1,25(OH)2D levels were significantly associated only with estimated CCr (R2 = 0. 409; P < 0.0001). CONCLUSIONS: These results suggest that hypoalbuminemia and the presence of DM independently affect serum 25(OH)D levels, probably via diabetic nephropathy and poor nutritional status associated with diabetes, and that 25(OH)D is actively catalyzed to 24,25(OH)2D in CRF, probably largely via extrarenal 24-hydroxylase. Serum levels of 1,25(OH)2D were significantly affected by the degree of renal failure. Thus, this study indicates that patients with CRF, particularly those with DM, should receive supplements containing the active form of vitamin D prior to dialysis. (+info)1,25-Dihydroxyvitamin D3 enhances the susceptibility of breast cancer cells to doxorubicin-induced oxidative damage. (4/2474)
1,25-Dihydroxyvitamin D3 (1,25(OH)2D3), the hormonal form of vitamin D, has anticancer activity in vivo and in vitro. Doxorubicin exerts its cytotoxic effect on tumor cells mainly by two mechanisms: (a) generation of reactive oxygen species (ROS); and (b) inhibition of topoisomerase II. We studied the combined cytotoxic action of 1,25(OH)2D3 and doxorubicin on MCF-7 breast cancer cells. Pretreatement with 1,25(OH)2D3 resulted in enhanced cytotoxicity of doxorubicin. The average enhancing effect after a 72-h pretreatment with 1,25(OH)2D3 (10 nM) followed by a 24-h treatment with 1 microg/ml doxorubicin was 74+/-9% (mean +/- SE). Under these experimental conditions, 1,25(OH)2D3 on its own did not affect cell number or viability. 1,25(OH)2D3 also enhanced the cytotoxic activity of another ROS generating quinone, menadione, but did not affect cytotoxicity induced by the topoisomerase inhibitor etoposide. The antioxidant N-acetylcysteine slightly reduced the cytotoxic activity of doxorubicin but had a marked protective effect against the combined action of 1,25(OH)2D3 and doxorubicin. These results indicate that ROS are involved in the interaction between 1,25(OH)2D3 and doxorubicin. 1,25(OH)2D3 also increased doxorubicin cytotoxicity in primary cultures of rat cardiomyocytes. Treatment of MCF-7 cells with 1,25(OH)2D3 alone markedly reduced the activity, protein, and mRNA levels of the cytoplasmic antioxidant enzyme Cu/Zn superoxide dismutase, which indicated that the hormone inhibits its biosynthesis. This reduction in the antioxidant capacity of the cells could account for the synergistic interaction between 1,25(OH)2D3 and doxorubicin and may also suggest increased efficacy of 1,25(OH)2D3 or its analogues in combination with other ROS-generating anticancer therapeutic modalities. (+info)Convergence of transforming growth factor-beta and vitamin D signaling pathways on SMAD transcriptional coactivators. (5/2474)
Cell proliferation and differentiation are regulated by growth regulatory factors such as transforming growth factor-beta (TGF-beta) and the liphophilic hormone vitamin D. TGF-beta causes activation of SMAD proteins acting as coactivators or transcription factors in the nucleus. Vitamin D controls transcription of target genes through the vitamin D receptor (VDR). Smad3, one of the SMAD proteins downstream in the TGF-beta signaling pathway, was found in mammalian cells to act as a coactivator specific for ligand-induced transactivation of VDR by forming a complex with a member of the steroid receptor coactivator-1 protein family in the nucleus. Thus, Smad3 may mediate cross-talk between vitamin D and TGF-beta signaling pathways. (+info)Regulation of PiT-1, a sodium-dependent phosphate co-transporter in rat parathyroid glands. (6/2474)
A cDNA encoding an Na+-Pi co-transporter, termed rat PiT-1, has now been isolated from rat parathyroid. Expression of rat PiT-1 in Xenopus oocytes revealed that it possesses Na+-dependent Pi co-transport activity. The amount of PiT-1 mRNA in the parathyroid of vitamin D-deficient rats was reduced compared with that in normal animals, and increased markedly after administration of 1,25-dihydroxyvitamin D3. Furthermore, the abundance of PiT-1 mRNA in the parathyroid was much greater in rats fed a low-Pi diet than in those fed a high-Pi diet. Thus, rat PiT-1 may contribute to the effects of Pi and vitamin D on parathyroid function. (+info)Regulation of vitamin D action. (7/2474)
The control of gene transcription by vitamin D compounds is initiated by binding to the VDR, which enhances the receptor's ability to heterodimerize to RXR, interact with response elements in target genes and attract components of the transcriptional initiation complex. A number of factors are capable of influencing this process, including (i) the rate of uptake and catabolism of the ligand, (ii) the nature of the conformational change induced by a specific ligand, (iii) the cellular content of the VDR, (iv) post-translational modifications of the VDR and (v) the availability of other transcriptional components. Vitamin D analogues may affect these factors differently to 1,25(OH)2D3 to produce unique biological profiles that can be exploited for therapeutic use. (+info)Topical psoriasis therapy. (8/2474)
Psoriasis is a common dermatosis, affecting from 1 to 3 percent of the population. Until recently, the mainstays of topical therapy have been corticosteroids, tars, anthralins and keratolytics. Recently, however, vitamin D analogs, a new anthralin preparation and topical retinoids have expanded physicians' therapeutic armamentarium. These new topical therapies offer increased hope and convenience to the large patient population with psoriasis. (+info)Direct inhibitory effect of calcitriol on parathyroid function (sigmoidal curve) in dialysis<...
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Calcitriol
Thus calcitriol also stimulates the intestinal absorption of phosphate. The observation that calcitriol stimulates the release ... PTH also stimulates the production of calcitriol (see below). Many of the effects of calcitriol are mediated by its interaction ... Calcitriol was identified as the active form of vitamin D in 1971 and the drug was approved for medical use in the United ... Calcitriol is produced in the cells of the proximal tubule of the nephron in the kidneys by the action of 25-hydroxyvitamin D3 ...
Parathyroid hormone
Carrillo-López N, Fernández-Martín JL, Cannata-Andía JB (2009-04-01). "[The role of calcium, calcitriol and their receptors in ... calcitriol), which is released into the circulation. This latter form of vitamin D is the active hormone which stimulates ... Calcitriol Increase in serum phosphate. Fibroblast growth factor-23 (FGF23) is produced in osteoblasts (from bone) in response ...
Roche
Rocaltrol (calcitriol), for osteoporosis and hypocalcaemia. Rocephin (ceftriaxone), a broad-spectrum cephalosporin antibiotic. ...
Vitamin D5
... (sitocalciferol) is a form of vitamin D. Analogs of calcitriol, a form of vitamin D3, have been proposed for use as ... The motive to study 1α-hydroxyvitamin D5 as a potential pharmaceutical drug stemmed from the tendency of calcitriol, a natural ... Thus, the therapeutic effects of 1α-Hydroxyvitamin D5 as a potential antitumor agent without the side effects of calcitriol ... Beer, Tomasz M.; Myrthue, Anne (March 2004). "Calcitriol in cancer treatment: from the lab to the clinic". Molecular Cancer ...
Falecalcitriol
... (INN) is an analog of calcitriol. It has a higher potency both in vivo and in vitro systems, and longer duration ...
Mater Misericordiae University Hospital
Caniggia A, Nuti R, Lore F, Martini G, Turchetti V, Righi G (April 1990). "Long-term treatment with calcitriol in ...
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Caniggia A, Nuti R, Lore F, Martini G, Turchetti V, Righi G (April 1990). "Long-term treatment with calcitriol in ...
TMEM211
... a heterodimer transcriptional coactivator that is dependent on calcitriol. Calcitriol is a form of vitamin D that is partly ... Calcitriol is also a molecule relied on by the lungs for proper function. Finally, TMEM211 displayed an extreme pattern of ... Calcitriol is also passed from nursing mothers in breastmilk. Furthermore, oral administration of estrogen has been shown to ... It is also of interest that calcitriol treatment has been shown to increase the expression of LHFPL RNA. The 5'UTR of TMEM211 ...
Fibroblast growth factor 23
... inhibition of production of calcitriol, stimulation of breakdown of calcitriol, and inhibition of production/secretion of ... FGF23 is secreted by osteocytes in response to increased calcitriol. FGF23 acts on the kidneys, where it decreases the ...
Bone resorption
Calcitriol (1,25-dihydroxycholecalciferol) is the active form of vitamin D3. It has numerous functions involved in blood ... Recent research indicates that calcitriol leads to a reduction in osteoclast formation, and bone resorption. It follows that an ... the precursor to calcitriol. Calcitonin is a hormone secreted by the thyroid in humans. Calcitonin decreases osteoclast ...
PDIA3
... may also participate in Vitamin D (specifically, calcitriol) signaling as a membrane-bound receptor. It has been ... November 2016). "Analysis of the interaction of calcitriol with the disulfide isomerase ERp57". Scientific Reports. 6: 37957. ...
Brown tumor
Calcitriol (Rocaltrol) and cinacalcet (a calcimimetic) are used as pharmacologic treatments. Age and gender have an effect on ...
McCune-Albright syndrome
Oral phosphate and calcitriol may be given for treatment of hypophosphatemia. For growth hormone excess, treatment with ...
Membrane steroid receptor
November 2016). "Analysis of the interaction of calcitriol with the disulfide isomerase ERp57". Scientific Reports. 6: 37957. ... PDIA3 is a membrane receptor for the secosteroid calcitriol, the activated form of Vitamin D. Semicolons roughly denote ...
Cyclooxygenase
Calcitriol (vitamin D) significantly inhibits the expression of the COX-2 gene. Caution should be exercised in combining low ...
Osteopontin
Synthesis of osteopontin is stimulated by calcitriol (1,25-dihydroxy-vitamin D3). Regulation of the osteopontin gene expression ... Hypocalcemia and hypophosphatemia (instances that stimulate kidney proximal tubule cells to produce calcitriol (1α,25- ...
Kidney
Calcitriol, the activated form of vitamin D, promotes intestinal absorption of calcium and the renal reabsorption of phosphate ... For example, they convert a precursor of vitamin D to its active form, calcitriol; and synthesize the hormones erythropoietin ... The kidneys secrete a variety of hormones, including erythropoietin, calcitriol, and renin. Erythropoietin is released in ...
Renal physiology
Calcitriol, the activated form of vitamin D, promotes intestinal absorption of calcium and the renal reabsorption of phosphate ... The kidneys secrete a variety of hormones, including erythropoietin, calcitriol, and renin. Erythropoietin is released in ...
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... calcitriol, performs its function through interactions with the calcitriol receptor. This nuclear hormone receptor is ... This greater affinity is 2.7-fold that of the active vitamin D form of calcitriol. Eldecalcitol is readily absorbed into the ... The chemistry of eldecalcitol allows for its binding 2.7-fold more potently than calcitriol. In addition, some vitamin D ... The eldecalcitol analog of calcitriol, contains a hydroxypropyl group in the lower cyclohexane ring. The synthesis of ...
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Hence the activation of naive T cells is crucially dependent on adequate calcitriol levels. In summary, activation of T cells ... However, activated TCR signaling through p38 upregulates VDR expression and calcitriol activated VDR, in turn, upregulates PLC- ... the expression of PLC-γ1 is dependent on VDR activated by calcitriol. Naive T cells have very low expression of VDR and PLC-γ1 ...
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Biochemically in blood, XLH is recognized by hypophosphatemia and an inappropriately low level of calcitriol (1,25-(OH)2 ... It is also treated with medications including human growth hormone, calcitriol, and phosphate. International XLH Alliance - an ... while calcitriol levels are low or within the lower reference range. Most importantly, urinary loss of phosphate is above the ... calcitriol; in the event of severe bowing, an osteotomy may be performed to correct the leg shape. The monoclonal antibody ...
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Elevated Calcitriol is suggestive of lymphoma, sarcoidosis, granulomatous disorders, and excessive calcitriol intake. Elevated ... These plants contain calcitriol or similar substances that cause rises in calcium ion levels. Hypercalcemia is most common in ... see calcitriol under Vitamin D) levels (e.g. sarcoidosis and other granulomatous diseases such as tuberculosis, berylliosis, ...
Homeostasis
It stimulates the manufacture and release, by the kidneys, of calcitriol into the blood. This steroid hormone acts on the ...
Cholecalciferol
The action of calcitriol is mediated by the vitamin D receptor, a nuclear receptor which regulates the synthesis of hundreds of ... It is converted in the liver to calcifediol (25-hydroxyvitamin D) which is then converted in the kidney to calcitriol (1,25- ... Hydroxylation in the kidneys of calcifediol to calcitriol by 1-alpha-hydroxylase is tightly regulated: it is stimulated by ... 25-Hydroxyvitamin D3 1-alpha-Hydroxylase, a kidney enzyme that converts calcifediol to calcitriol. Coulston AM, Boushey C, ...
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It has been suggested, based on animal research, that calcitriol, the active metabolite of vitamin D, can provide significant ... Cass WA, Smith MP, Peters LE (2006). "Calcitriol protects against the dopamine- and serotonin-depleting effects of neurotoxic ...
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Expression could be induced by treating these animals with vitamin D metabolites such as calcitriol. They were found to exist ... Expression of S100G, like that of calbindin 1, is stimulated by the active vitamin D metabolite, calcitriol although the ...
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Atkins KB, Troen BR (July 1995). "Regulation of cathepsin D gene expression in HL-60 cells by retinoic acid and calcitriol". ...
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ESRD occurs when the kidneys fail to produce calcitriol, a form of vitamin D, which assists in the absorption of calcium into ... When calcitriol levels decrease, parathyroid hormone levels increase, halting the storage of calcium, and instead triggering ... Medical management of OFC consists of vitamin D treatment, generally alfacalcidol or calcitriol, delivered intravenously. ...
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... calcitriol), and other vitamin D metabolites, fibroblast growth factor 23 (FGF-23), and growth hormone. Beginning in CKD stage ...
Calcitriol: MedlinePlus Drug Information
Calcitriol: learn about side effects, dosage, special precautions, and more on MedlinePlus ... If you become pregnant while taking calcitriol, call your doctor. You should not breastfeed while you are taking calcitriol. ... Calcitriol comes as a capsule and a solution (liquid) to take by mouth. It usually is taken once a day or once every other day ... Calcitriol will work only if you get the right amount of calcium from the foods you eat. If you get too much calcium from foods ...
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... calcitriol ointment as adjunctive therapy to topical steroids was beneficial in continuing to suppress the re-emergence of ... Calcitriol ointment has been approved for use in Europe for many years and was approved by the US Food and Drug Administration ... At the end of that period, they were switched to calcitriol ointment (3 μg/g), an active form of vitamin D, self-applied twice ... March 17, 2009 (San Francisco, California) - Calcitriol ointment as adjunctive therapy to topical steroids is beneficial in ...
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The concurrent use of calcitriol (CAL) pulse therapy to reduce parathyroid hormone (PTH) secretion and of calcium (Ca) salts as ... Calcitriol pulse therapy for severe hyperparathyroidism or calcium salts as phosphate binders in renal dialysis patients? ... The concurrent use of calcitriol (CAL) pulse therapy to reduce parathyroid hormone (PTH) secretion and of calcium (Ca) salts as ...
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Calcitriol and Tropicamide drug interactions, a phase IV clinical study of FDA data - eHealthMe
Drug interactions are found among 2 people who take Calcitriol and Tropicamide. See what the interactions are and for which ... What is Calcitriol?. Calcitriol has active ingredients of calcitriol. It is often used in hypoparathyroidism. eHealthMe is ... Common Calcitriol interactions:. *Calcitriol and Acetaminophen: 511 reports. *Calcitriol and Acetylsalicylic acid: 737 reports ... It is based on calcitriol and tropicamide (the active ingredients of Calcitriol and Tropicamide, respectively), and Calcitriol ...
Systemic Jak1 activation causes extrarenal calcitriol production and skeletal alterations provoking stunted growth - Zurich...
... and higher calcitriol levels. The higher calcitriol levels are probably due to extrarenal calcitriol production. Furthermore, ... and higher calcitriol levels. The higher calcitriol levels are probably due to extrarenal calcitriol production. Furthermore, ... Mineral homeostasis is regulated by a complex network involving endocrine actions by calcitriol, parathyroid hormone (PTH), and ... Mineral homeostasis is regulated by a complex network involving endocrine actions by calcitriol, parathyroid hormone (PTH), and ...
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Decrease quantity for Calcitriol Compound Solution 100 ng/ml, 15 ml Increase quantity for Calcitriol Compound Solution 100 ng/ ... Calcitriol may also be useful in treating some types of matopathis such as primary idiopathic seborrhea. Calcitriol is ... Calcitriol is an "activated" vitamin D that is used as an adjunctive treatment for chronic renal disease in cats and dogs. ... Calcitriol is an "activated" vitamin D that is used as an adjunctive treatment for chronic renal disease in cats and dogs. ...
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calcitriol biosynthetic process from calciol vitamin D3 25-hydroxylase activity (GO:0030343) BFO:0000050 calcitriol ... calcitriol biosynthetic process from calciol. Ontology. biological_process. Synonyms. calcitriol biosynthesis from calciol, ... calcitriol biosynthetic process from calciol is_a vitamin D biosynthetic process (GO:0042368) ... calcitriol biosynthetic process from calciol is_a vitamin D3 metabolic process (GO:0070640) ...
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Calcitriol belongs to the group of medications called vitamin D3 metabolites. Calcitriol is a form of vitamin D that is active ... Do not use calcitriol if you:. *are allergic to calcitriol, vitamin D or forms of vitamin D, or any ingredients of the ... Calcitriol belongs to the group of medications called vitamin D3 metabolites. Calcitriol is a form of vitamin D that is active ... Calcitriol is used to help increase the amount of calcium in the blood and help with proper bone formation for people with ...
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Calcitriol - Top Med Store
Calcitriol is a man-made Vitamin D that helps to control parathyroid hormone and the levels of certain minerals like calcium, ... which is a hydroxy calciol in which the pro-S hydrogen of calcitriol is replaced by a hydroxy group. It plays the role of a ... Calcium in the given medicine Calcitriol plays an important role in maintaining bone health, and low levels of calcium. This ... Calcitriol medication is a Vitamin D3 Analog, which is a hydroxy calciol in which the pro-S hydrogen of calcitriol is replaced ...
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0.25 mcgVitaminParathyroid hormoneTake calcitriolCapsule2022HypercalcemiaSide effects of calcitriolCalcijexElevated calcitriol levelsBoneTell your doctor and pharmacistMedicationCholecalciferolComprar calcitriolInjectionDoseDosageCalcidiolSevere hyperparathyroidismKidneyIntestinalCalcium levelsIncreases blood levels of calciumRenalMagnesiumHyperparathyroidismKidneysOintmentDosesLevelsPsoriasis2018IngredientsPregnantHttpsDietaryPatients
0.25 mcg5
- The recommended initial dosage of calcitriol is 0.25 mcg/day in adults and pediatric patients 3 years of age and older . (drk-schluechtern.de)
- The recommended dose of Calcitriol capsule is 0.25 mcg twice daily. (kjhbazar.com)
- The initial daily dose is 0.25 mcg of Calcitriol capsule. (kjhbazar.com)
- The recommended initial dosage of Calcitriol capsule is 0.25 mcg/day which given in the morning. (kjhbazar.com)
- Al respecto de los productos farmacéuticos solicitados se evidencia que en el Petitorio Nacional Único de Medicamentos - PNUME vigente sólo se ha incluido al Calcitriol de 1mcg/mL y el Calcitriol de 0.25 mcg, no encontrándose Solución de Joulie (fosfato disódico+ácido fosfárico), Litiasin (citrat. (bvsalud.org)
Vitamin37
- Calcitriol is in a class of medications called vitamin D analogs. (medlineplus.gov)
- Calcitriol is also sometimes used to treat rickets (softening and weakening of bones in children caused by lack of vitamin D), osteomalacia (softening and weakening of bones in adults caused by lack of vitamin D), and familial hypophosphatemia (rickets or osteomalacia caused by decreased ability to break down vitamin D in the body). (medlineplus.gov)
- At the end of that period, they were switched to calcitriol ointment (3 μg/g), an active form of vitamin D, self-applied twice a day for up to 8 weeks. (medscape.com)
- Calcitriol is an "activated" vitamin D that is used as an adjunctive treatment for chronic renal disease in cats and dogs. (thrivingpets.com)
- Conversion of vitamin D3 from its largely inactive form (calciol, also called cholecalciferol) into a hormonally active form (calcitriol). (planteome.org)
- Calcitriol is a form of vitamin D that is active in the body. (pharmachoice.com)
- Calcitriol may also be used to treat vitamin D-resistant rickets, a bone disease caused by too little vitamin D. (pharmachoice.com)
- Calcitriol medication is a Vitamin D3 Analog, which is a hydroxy calciol in which the pro-S hydrogen of calcitriol is replaced by a hydroxy group. (thetopmedstore.com)
- Calcitriol is a man-made Vitamin D that helps to control parathyroid hormone and the levels of certain minerals like calcium, phosphorus. (thetopmedstore.com)
- Calcitriol is a topical vitamin D analog similar to calcipotriene but seems to be less irritating in sensitive areas of skin. (medscape.com)
- Symptoms of calcitriol toxicity mirrors the early and late signs and symptoms of vitamin D intoxication associated with hypercalcemia 10 . (drk-schluechtern.de)
- Calcitriol is a form of vitamin D3. (drk-schluechtern.de)
- Is calcitriol better than vitamin D? (drk-schluechtern.de)
- Can you take calcitriol and vitamin D together? (drk-schluechtern.de)
- Calcitriol is very similar to other forms of vitamin D. Do not use medications containing other forms of vitamin D while using calcitriol . (drk-schluechtern.de)
- Is calcitriol the same as vitamin D3? (drk-schluechtern.de)
- Calcitriol, which is actually the most active form of vitamin D [100-times higher than 25(OH)D3] has a very short half-life, of about a few hours. (drk-schluechtern.de)
- How many units of vitamin D are in calcitriol? (drk-schluechtern.de)
- To compare the effects of cholecalciferol (800 IU/d) and calcitriol ( 0.25 μg/d ) on calcium metabolism and bone turnover in Chinese postmenopausal women with vitamin D insufficiency. (drk-schluechtern.de)
- Rocaltrol (Calcitriol) is a form of vitamin D, necessary for normal bone development. (boldbare.com)
- Calcitriol is vitamin D3. (boldbare.com)
- You should not use this medication if you have high levels of calcium or vitamin D in your blood, or if you have ever had an allergic reaction to calcitriol or other forms of vitamin D. Drink plenty of fluids unless your doctor has told you to restrict your fluid intake. (boldbare.com)
- Vitamin D's active form is calcitriol. (adenhealthcare.com)
- hydroxylase enzyme, preventing the conversion of vitamin D into the active form of calcitriol. (paediatricaindonesiana.org)
- Decreased vitamin D levels may occur at an early stage of the disease, so it is important to evaluate calcitriol levels in children with early stage CKD. (paediatricaindonesiana.org)
- Calcitriol 's improvement of control barrier function was not additive to barrier improvement induced by retinoic acid ( Vitamin A ). Calcitriol improvement and protection of airway barrier function could in part explain Vitamin D 's reported clinical efficacy in COVID-19 and other airway diseases . (bvsalud.org)
- To understand vitamin D pharmocology one needs to be familiar with the different forms of vitamin D, namely cholecalciferol, calcidiol, and calcitriol. (vitamindcouncil.org)
- It is sometimes referred to as the active form of vitamin D. Calcitriol levels should never be used to determine if you are deficient in vitamin D. (vitamindcouncil.org)
- Since calcitriol is one of the most important active metabolites of vitamin D3, pharmacological doses of vitamin D and its derivatives should be withheld during treatment with calcitriol to avoid possible additive effects and hypercalcemia. (mims.com)
- Offering you a complete choice of products which include calcium carbonate calcium calcitriol vitamin k 2 7. (gemedlifesciences.com)
- Standard protocol for treatment of familial hypophosphatemic rickets includes the use of 1,25-dihydroxy-vitamin D (calcitriol). (medscape.com)
- The use of calcitriol in place of standard vitamin D obviates near-toxic dosage of the latter, avoids fat storage of parent vitamin D, and diminishes the danger of hypercalcemia. (medscape.com)
- Calcitriol is one of the most important active metabolites of vitamin D3. (kjhbazar.com)
- Vitamin D becomes active in the body after a two-stage synthesising process that converts vitamin D3 - predominantly produced by sunlight on skin - into calcitriol, the most potent steroid hormone in the body. (antiaging-nutrition.com)
- Because vitamin D's active hormone, calcitriol, is particularly beneficial to bone health due to its role in aiding calcium and phosphorous absorption, a deficiency can lead to thin, brittle, misshapen bones, or the bone disease, osteomalacia (known as rickets in children). (antiaging-nutrition.com)
- Once vitamin D is absorbed from food or produced in the skin, it travels to the liver and kidneys, transforming it into its active form, calcitriol. (ziggiesocial.com)
- This means your body needs the right amount of vitamin D3 (also known as calcitriol) before it can convert it into a hormone produced by the kidney. (happyhealthyhippieco.com)
Parathyroid hormone2
- The concurrent use of calcitriol (CAL) pulse therapy to reduce parathyroid hormone (PTH) secretion and of calcium (Ca) salts as the most appropriate phosphate binders was evaluated for over 1 year in a group of 14 patients with good divalent ion control on CaCO3 therapy but with increasing levels of serum intact PTH. (nih.gov)
- Mineral homeostasis is regulated by a complex network involving endocrine actions by calcitriol, parathyroid hormone (PTH), and FGF23 on several organs including kidney, intestine, and bone. (uzh.ch)
Take calcitriol7
- Take calcitriol exactly as directed. (medlineplus.gov)
- Your doctor will probably tell you not to take calcitriol. (medlineplus.gov)
- Drug interactions are reported only by a few people who take Calcitriol and Tropicamide together. (ehealthme.com)
- The phase IV clinical study analyzes what interactions people who take Calcitriol and Tropicamide have. (ehealthme.com)
- 2 people who take Calcitriol and Tropicamide together, and have interactions are studied. (ehealthme.com)
- Do you take Calcitriol and Tropicamide? (ehealthme.com)
- To make sure you can safely take calcitriol, tell your doctor about all of your medical conditions. (boldbare.com)
Capsule4
- Calcitriol comes as a capsule and a solution (liquid) to take by mouth. (medlineplus.gov)
- Each orange, opaque, oval, soft gelatin capsule with "O25" printed in black contains 0.25 µg of calcitriol. (pharmachoice.com)
- Each orangeish-to-red, opaque, oval, soft gelatin capsule with "O50" printed in black contains 0.50 µg of calcitriol. (pharmachoice.com)
- The optimal daily dose of Calcitriol capsule must be carefully determined for each patient on the basis of serum calcium level. (kjhbazar.com)
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Hypercalcemia3
- 1.0cm, and hypercalcemia) in dialysis patients may be resistant to conventional calcitriol- pulse therapy. (yonsei.ac.kr)
- Calcitriol dosage must be determined with care in patients undergoing treatment with digitalis, as hypercalcemia in such patients may precipitate cardiac arrhythmias. (mims.com)
- Calcitriol is also contraindicated in all diseases associated with hypercalcemia. (kjhbazar.com)
Side effects of calcitriol1
- If you get too much calcium from foods, you may experience serious side effects of calcitriol, and if you do not get enough calcium from foods, calcitriol will not control your condition. (medlineplus.gov)
Calcijex3
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Elevated calcitriol levels1
- Ultimately elevated calcitriol levels increase calciuria and kidney stones . (drk-schluechtern.de)
Bone11
- Calcitriol is used to treat and prevent low levels of calcium and bone disease in patients whose kidneys or parathyroid glands (glands in the neck that release natural substances to control the amount of calcium in the blood) are not working normally. (medlineplus.gov)
- Calcitriol is used to help increase the amount of calcium in the blood and help with proper bone formation for people with chronic kidney failure that are undergoing dialysis. (pharmachoice.com)
- Calcium in the given medicine Calcitriol plays an important role in maintaining bone health, and low levels of calcium. (thetopmedstore.com)
- Calcitriol is used to treat hyperparathyroidism (overactive parathyroid glands) and metabolic bone disease in people who have chronic kidney failure and are not receiving dialysis . (drk-schluechtern.de)
- Calcitriol is used to treat and prevent low calcium levels and bone damage in people whose kidneys or parathyroid glands are malfunctioning. (adenhealthcare.com)
- Other treatment options include calcitriol, GH, phosphates, and anticalciurics to promote healthy bone growth and diminish mineral loss associated with hypophosphatemic rickets. (medscape.com)
- Calcitriol promotes intestinal absorption of calcium and regulates bone mineralization. (kjhbazar.com)
- D3 Pro 2 and D3 5000 provide an alternative way for the body to produce calcitriol and support bone health, while reducing the risk of numerous diseases and deficiency symptoms. (antiaging-nutrition.com)
- Calcitriol then binds to receptors on cells all over the body, including bone cells, intestine cells, and immune cells. (ziggiesocial.com)
- By binding to these receptors, calcitriol helps to regulate a wide range of processes, including calcium absorption, bone growth, and immune function. (ziggiesocial.com)
- Treatment with intermittent calcitriol and calcium reduces bone loss after renal transplantation. (cdc.gov)
Tell your doctor and pharmacist1
- tell your doctor and pharmacist if you are allergic to calcitriol, any other medications, or any of the ingredients in calcitriol ointment. (epnet.com)
Medication2
- Calcitriol is a prescription medication commonly used in the treatment of conditions caused by high or low parathyroid levels. (entirelypetspharmacy.com)
- If your pet has been diagnosed with chronic kidney disease, parathyroid disorder, or an associated disease, your veterinarian may prescribe a medication such as calcitriol. (entirelypetspharmacy.com)
Cholecalciferol1
- However, some of your cholecalciferol will be turned into calcitriol, a very potent steroid with anti-cancer properties. (vitamindcouncil.org)
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Injection2
- We three repeatedly injected calcitriol of dose(μg) equal to 3-D nodule volume(cm(3)) under U.S.(Acuson Computa Sono, California, USA, 7MHz probe) for 1 week and concurrently began calcitriol-pulse therapy(0.75-1.0μg/day, t.i.w.) after 3rd injection. (yonsei.ac.kr)
- The recommended intravenous initial dose of Calcitriol injection, depending on the severity of the hypocalcemia and/or secondary hyperparathyroidism, is 1 mcg (0.02 mcg/kg) to 2 mcg administered three times weekly, approximately every other day. (kjhbazar.com)
Dose3
- Your doctor will probably start you on a low dose of calcitriol and may gradually increase your dose depending on your body's response to calcitriol. (medlineplus.gov)
- The recommended starting dose of calcitriol for adults is 0.25 µg daily. (pharmachoice.com)
- Do not stop taking Calcitriol-AFT or change the dose without first checking with your doctor. (drk-schluechtern.de)
Dosage3
- For pediatric patients less than 3 years of age, the recommended initial dosage of calcitriol is 10 to 15 ng/kg/day. (drk-schluechtern.de)
- Since calcitriol also has an effect on phosphate transport in the intestine, kidneys and bones, the dosage of phosphate binding agents must be adjusted in accordance with the serum phosphate concentration (normal values: 2.5 mg/100 mL or 0.6-1.6 mmol/L). (mims.com)
- 120 µmol/l, the dosage of Calcitriol should be substantially reduced or treatment stopped. (kjhbazar.com)
Calcidiol3
- Conversion requires 25-hydroxylation of calciol in the liver to form calcidiol, and subsequent 1,alpha-hydroxylation of calcidiol in the kidney to form calcitriol. (planteome.org)
- calcidiol and calcitriol. (vitamindcouncil.org)
- the kidney's inability to convert calcidiol to calcitriol. (antiaging-nutrition.com)
Severe hyperparathyroidism1
- Calcitriol pulse therapy for severe hyperparathyroidism or calcium salts as phosphate binders in renal dialysis patients? (nih.gov)
Kidney3
- If you do not have kidney disease, you should drink plenty of fluids while taking calcitriol. (medlineplus.gov)
- While calcitriol was first thought to be generated solely in the kidney, it is now recognized in many extrarenal tissues (10-12). (drk-schluechtern.de)
- Can calcitriol cause kidney stones? (drk-schluechtern.de)
Intestinal5
- abametapir will increase the level or effect of calcitriol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. (medscape.com)
- apalutamide will decrease the level or effect of calcitriol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. (medscape.com)
- clarithromycin will increase the level or effect of calcitriol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. (medscape.com)
- enzalutamide will decrease the level or effect of calcitriol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. (medscape.com)
- Cholestyramine can reduce intestinal absorption of fat-soluble vitamins and therefore may impair intestinal absorption of calcitriol. (mims.com)
Calcium levels3
- BARRO-CT is the fusion of various compositions of Calcium Citrate, Elemental Calcium And Calcitriol tablets which is a combo medicine intended to prevent or treat low blood calcium levels in patients who do not consume enough calcium from their daily diet. (adenhealthcare.com)
- Calcitriol increases calcium levels by promoting calcium absorption in the intestines and retention in kidneys. (medscape.com)
- Mothers may breast feed while taking Calcitriol but serum calcium levels of the mother and infant should be monitored. (kjhbazar.com)
Increases blood levels of calcium1
- Calcitriol increases blood levels of calcium by increasing the absorption of calcium in the kidneys , increasing the absorption of calcium and phosphorus from the intestine, and increasing the release of calcium and phosphorus from the bones. (drk-schluechtern.de)
Renal1
- Magnesium-containing drugs (eg, antacids) may cause hypermagnesemia and should therefore not be taken during therapy with calcitriol by patients on chronic renal dialysis. (mims.com)
Magnesium1
- Obat yang mengandung magnesium seperti antasida tidak boleh diberikan secara bersama Calcitriol pada dialysis ginjal kronik karena dapat menyebabkan hypermagnesium. (pt-ana.com)
Hyperparathyroidism3
- These combination therapy could significantly decrease i-PTH level and gland volume in patients with resistant secondary hyperparathyroidism on conventional calcitriol therapy and the response were main-tained for one year after start of these therapy. (yonsei.ac.kr)
- In conclusion, direct calcitriol injections into the parathyroid nodules and pulse combination therapy could be useful in secondary resistant hyperparathyroidism patients with conventional calcitriol therapy especially in those with i-PTH of less than 1,200pg/ml or gland volume of less than 1.5cm. (yonsei.ac.kr)
- Over time, the parathyroid glands become hyperplastic and less susceptible to treatment with calcium and calcitriol, producing a continuous secret ion of PTH and result ing secondar y hyperparathyroidism 3 . (bvsalud.org)
Kidneys1
- Is calcitriol good for your kidneys? (drk-schluechtern.de)
Ointment15
- March 17, 2009 (San Francisco, California) - Calcitriol ointment as adjunctive therapy to topical steroids is beneficial in continuing to suppress the re-emergence of plaque psoriasis. (medscape.com)
- Calcitriol ointment has been approved for use in Europe for many years and was approved by the US Food and Drug Administration last month. (medscape.com)
- Calcitriol ointment is used to treat mild to moderate psoriasis (a skin disease in which red, scaly patches form on some areas of the body). (epnet.com)
- Calcitriol comes as an ointment to apply to the skin. (epnet.com)
- Apply calcitriol ointment at around the same times every day. (epnet.com)
- Apply calcitriol ointment exactly as directed. (epnet.com)
- Do not use more than two tubes of calcitriol ointment per week. (epnet.com)
- Apply calcitriol ointment to the areas of skin affected by psoriasis. (epnet.com)
- Do not apply calcitriol ointment to healthy skin or anywhere on your face, eyes, lips, or vagina. (epnet.com)
- Do not cover the skin where you applied calcitriol ointment with a bandage or dressing unless your doctor tells you that you should. (epnet.com)
- Wash your hands well with soap and water after you apply calcitriol ointment. (epnet.com)
- Many other medications may also interact with calcitriol ointment, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list. (epnet.com)
- Calcitriol ointment may make your skin sensitive to sunlight. (epnet.com)
- Calcitriol ointment may cause side effects. (epnet.com)
- Do not freeze or refrigerate calcitriol ointment. (epnet.com)
Doses4
- Therefore, higher doses of calcitriol may be necessary if these drugs are administered simultaneously. (mims.com)
- Calcitriol protects against the dopamine- and serotonin-depleting effects of neurotoxic doses of methanphetamine. (bvsalud.org)
- High oral doses of alpha calcitriol and calcium with i.v. infusion of high calcium doses were instituted, altogether sufficient to maintain only mild hypocalcaemia. (bioscientifica.com)
- Serum calcium was kept stable close to the low normal range by high doses of oral alpha calcitriol and calcium. (bioscientifica.com)
Levels12
- Here, we used a mouse model (Jak1S645P+/- ) that resembles a constitutive activating mutation of the Jak1/Stat3 signaling pathway in humans, and shows altered mineral metabolism, with higher fibroblast growth factor 23 (FGF23) levels, lower PTH levels, and higher calcitriol levels. (uzh.ch)
- The higher calcitriol levels are probably due to extrarenal calcitriol production. (uzh.ch)
- To our knowledge, no previous studies have assessed calcitriol levels in children with CKD. (paediatricaindonesiana.org)
- Objective To assess calcitriol levels in children with CKD according to disease stage and other characteristics. (paediatricaindonesiana.org)
- Univariate and multivariate analyses were conducted to determine the association between calcitriol levels with disease stage and other characteristics. (paediatricaindonesiana.org)
- Results The overall mean calcitriol level of our subjects was 108.77 (SD 10.79) pmol/L. Mean levels at each CKD stage from I to V were 164.28 (SD 160.90), 94.14 (SD 50.63), 72.16 (SD 13.18), 62.92 (SD 4.87), and 67.51 (SD 4.87) pmol/L, respectively. (paediatricaindonesiana.org)
- Calcitriol levels did not differ significantly by CKD stage (P=0.114) when each stage from I to V was considered separately. (paediatricaindonesiana.org)
- There was no significant difference in calcitriol levels by growth characteristics (P=0.944), etiology (P=0.311), or anemic status (P=0.104). (paediatricaindonesiana.org)
- However, low calcitriol levels were found in all subjects with advanced stage CKD, compared to 63.6% subjects with early stage CKD (P=0.004). (paediatricaindonesiana.org)
- Mean calcitriol levels were significantly lower in CKD stage IV (P=0.049) and stage V (P=0.027) compared to stage I. (paediatricaindonesiana.org)
- Calcitriol levels are significantly lower in advanced stage than in early stage CKD. (paediatricaindonesiana.org)
- This was supported by calcitriol being without effect on pERK levels elevated by the action of TNF-α. (bvsalud.org)
Psoriasis1
- AAD 2009: Calcitriol Maintains Suppression of Psoriasis - Medscape - Mar 17, 2009. (medscape.com)
20182
- numerous factors of the Calcitriol (CAS 32222-06-3) business just like the offer chain state of affairs, business standards, import/export details also are mentioned in world Calcitriol (CAS 32222-06-3) Market 2018 report. (timesofkabul.com)
- In conclusion, world Calcitriol (CAS 32222-06-3) market 2018 report presents the descriptive analysis of the parent market supported elite players, present, past and artistic movement information which is able to function a profitable guide for all the Calcitriol (CAS 32222-06-3) business competitors. (timesofkabul.com)
Ingredients2
- Calcitriol has active ingredients of calcitriol . (ehealthme.com)
- Calcitriol is contraindicated in patients with known hypersensitivity to any of its ingredients. (kjhbazar.com)
Pregnant1
- If you become pregnant while taking calcitriol, call your doctor. (medlineplus.gov)
Https1
- https://www.selleckchem.com/products/Calcitriol-(R. (uchatoo.com)
Dietary1
- While you are taking calcitriol, it is important that you follow any dietary suggestions your doctor has provided. (pharmachoice.com)
Patients2
- You can tell from the photographs that some patients did continue to improve during the last 8 weeks of the study," after the steroids were stopped and calcitriol was used, she told Medscape Dermatology . (medscape.com)
- Un groupe de 69 patients atteints de diabète de type 1 et 45 témoins en bonne santé sans lien entre eux ont été recrutés pour cette étude. (who.int)