The physiologically active form of vitamin D. It is formed primarily in the kidney by enzymatic hydroxylation of 25-hydroxycholecalciferol (CALCIFEDIOL). Its production is stimulated by low blood calcium levels and parathyroid hormone. Calcitriol increases intestinal absorption of calcium and phosphorus, and in concert with parathyroid hormone increases bone resorption.
Proteins, usually found in the cytoplasm, that specifically bind calcitriol, migrate to the nucleus, and regulate transcription of specific segments of DNA with the participation of D receptor interacting proteins (called DRIP). Vitamin D is converted in the liver and kidney to calcitriol and ultimately acts through these receptors.
Calcium Channel Agonists
Agents that increase calcium influx into calcium channels of excitable tissues. This causes vasoconstriction in VASCULAR SMOOTH MUSCLE and/or CARDIAC MUSCLE cells as well as stimulation of insulin release from pancreatic islets. Therefore, tissue-selective calcium agonists have the potential to combat cardiac failure and endocrinological disorders. They have been used primarily in experimental studies in cell and tissue culture.
A polypeptide hormone (84 amino acid residues) secreted by the PARATHYROID GLANDS which performs the essential role of maintaining intracellular CALCIUM levels in the body. Parathyroid hormone increases intracellular calcium by promoting the release of CALCIUM from BONE, increases the intestinal absorption of calcium, increases the renal tubular reabsorption of calcium, and increases the renal excretion of phosphates.
A vitamin that includes both CHOLECALCIFEROLS and ERGOCALCIFEROLS, which have the common effect of preventing or curing RICKETS in animals. It can also be viewed as a hormone since it can be formed in SKIN by action of ULTRAVIOLET RAYS upon the precursors, 7-dehydrocholesterol and ERGOSTEROL, and acts on VITAMIN D RECEPTORS to regulate CALCIUM in opposition to PARATHYROID HORMONE.
A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.
A clinical syndrome associated with the retention of renal waste products or uremic toxins in the blood. It is usually the result of RENAL INSUFFICIENCY. Most uremic toxins are end products of protein or nitrogen CATABOLISM, such as UREA or CREATININE. Severe uremia can lead to multiple organ dysfunctions with a constellation of symptoms.
25-Hydroxyvitamin D3 1-alpha-Hydroxylase
A mitochondrial cytochrome P450 enzyme that catalyzes the 1-alpha-hydroxylation of 25-hydroxyvitamin D3 (also known as 25-hydroxycholecalciferol) in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP27B1 gene, converts 25-hydroxyvitamin D3 to 1-alpha,25-dihydroxyvitamin D3 which is the active form of VITAMIN D in regulating bone growth and calcium metabolism. This enzyme is also active on plant 25-hydroxyvitamin D2 (ergocalciferol).
A condition of abnormally elevated output of PARATHYROID HORMONE (or PTH) triggering responses that increase blood CALCIUM. It is characterized by HYPERCALCEMIA and BONE RESORPTION, eventually leading to bone diseases. PRIMARY HYPERPARATHYROIDISM is caused by parathyroid HYPERPLASIA or PARATHYROID NEOPLASMS. SECONDARY HYPERPARATHYROIDISM is increased PTH secretion in response to HYPOCALCEMIA, usually caused by chronic KIDNEY DISEASES.
Vitamin D Response Element
A condition caused by a deficiency of PARATHYROID HORMONE (or PTH). It is characterized by HYPOCALCEMIA and hyperphosphatemia. Hypocalcemia leads to TETANY. The acquired form is due to removal or injuries to the PARATHYROID GLANDS. The congenital form is due to mutations of genes, such as TBX1; (see DIGEORGE SYNDROME); CASR encoding CALCIUM-SENSING RECEPTOR; or PTH encoding parathyroid hormone.
Phosphorus used in foods or obtained from food. This element is a major intracellular component which plays an important role in many biochemical pathways relating to normal physiological functions. High concentrations of dietary phosphorus can cause nephrocalcinosis which is associated with impaired kidney function. Low concentrations of dietary phosphorus cause an increase in calcitriol in the blood and osteoporosis.
Bone Density Conservation Agents
Disorders caused by interruption of BONE MINERALIZATION manifesting as OSTEOMALACIA in adults and characteristic deformities in infancy and childhood due to disturbances in normal BONE FORMATION. The mineralization process may be interrupted by disruption of VITAMIN D; PHOSPHORUS; or CALCIUM homeostasis, resulting from dietary deficiencies, or acquired, or inherited metabolic, or hormonal disturbances.
An inherited condition of abnormally low serum levels of PHOSPHATES (below 1 mg/liter) which can occur in a number of genetic diseases with defective reabsorption of inorganic phosphorus by the PROXIMAL RENAL TUBULES. This leads to phosphaturia, HYPOPHOSPHATEMIA, and disturbances of cellular and organ functions such as those in X-LINKED HYPOPHOSPHATEMIC RICKETS; OSTEOMALACIA; and FANCONI SYNDROME.
Bone and Bones
Vitamin K-dependent calcium-binding protein synthesized by OSTEOBLASTS and found primarily in BONES. Serum osteocalcin measurements provide a noninvasive specific marker of bone metabolism. The protein contains three residues of the amino acid gamma-carboxyglutamic acid (Gla), which, in the presence of CALCIUM, promotes binding to HYDROXYAPATITE and subsequent accumulation in BONE MATRIX.
Familial Hypophosphatemic Rickets
Kidney Failure, Chronic
The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION.
S100 Calcium Binding Protein G
A calbindin protein found in many mammalian tissues, including the UTERUS, PLACENTA, BONE, PITUITARY GLAND, and KIDNEYS. In intestinal ENTEROCYTES it mediates intracellular calcium transport from apical to basolateral membranes via calcium binding at two EF-HAND MOTIFS. Expression is regulated in some tissues by VITAMIN D.
A class of G-protein-coupled receptors that react to varying extracellular CALCIUM levels. Calcium-sensing receptors in the PARATHYROID GLANDS play an important role in the maintenance of calcium HOMEOSTASIS by regulating the release of PARATHYROID HORMONE. They differ from INTRACELLULAR CALCIUM-SENSING PROTEINS which sense intracellular calcium levels.
Vitamin D Deficiency
A nutritional condition produced by a deficiency of VITAMIN D in the diet, insufficient production of vitamin D in the skin, inadequate absorption of vitamin D from the diet, or abnormal conversion of vitamin D to its bioactive metabolites. It is manifested clinically as RICKETS in children and OSTEOMALACIA in adults. (From Cecil Textbook of Medicine, 19th ed, p1406)
25-Hydroxyvitamin D 2
Dose-Response Relationship, Drug
Fibroblast Growth Factors
A family of small polypeptide growth factors that share several common features including a strong affinity for HEPARIN, and a central barrel-shaped core region of 140 amino acids that is highly homologous between family members. Although originally studied as proteins that stimulate the growth of fibroblasts this distinction is no longer a requirement for membership in the fibroblast growth factor family.
Phosphorus Metabolism Disorders
Renal Insufficiency, Chronic
Conditions in which the KIDNEYS perform below the normal level for more than three months. Chronic kidney insufficiency is classified by five stages according to the decline in GLOMERULAR FILTRATION RATE and the degree of kidney damage (as measured by the level of PROTEINURIA). The most severe form is the end-stage renal disease (CHRONIC KIDNEY FAILURE). (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002)
Vitamin D regulates human ectocervical epithelial cell proliferation and insulin-like growth factor-binding protein-3 level. (1/2474)The differentiation status of the cervical epithelial cell has an important influence on responsiveness to estrogens and progestins. Several agents, including glucocorticoids and retinoids, are known to influence cervical cell differentiation. However, the effects of vitamin D have not been examined. Vitamin D is known to regulate cell proliferation and gene expression in a variety of epithelial cells. In the present study we investigated the ability of 1alpha25-dihydroxyvitamin D3 (D3) to regulate cell proliferation and expression of insulin-like growth factor-binding protein-3 (IGFBP-3) in human ectocervical epithelial cells. ECE16-1, a non-tumorigenic cervical cell line, was growth inhibited by D3 with maximal inhibition at 1000 nM. IGFBP-3 levels increased in parallel with the growth inhibition. IGFBP-3 levels were half-maximally increased at approximately 10-100 nM and maximally increased (10- to 30-fold) at 1000 nM D3. These studies show that vitamin D regulates cervical epithelial cell gene regulation and cell proliferation and that IGFBP-3 may be an in vivo marker of vitamin D action in the cervix. (+info)
22-oxacalcitriol suppresses secondary hyperparathyroidism without inducing low bone turnover in dogs with renal failure. (2/2474)BACKGROUND: Calcitriol therapy suppresses serum levels of parathyroid hormone (PTH) in patients with renal failure but has several drawbacks, including hypercalcemia and/or marked suppression of bone turnover, which may lead to adynamic bone disease. A new vitamin D analogue, 22-oxacalcitriol (OCT), has been shown to have promising characteristics. This study was undertaken to determine the effects of OCT on serum PTH levels and bone turnover in states of normal or impaired renal function. METHODS: Sixty dogs were either nephrectomized (Nx, N = 38) or sham-operated (Sham, N = 22). The animals received supplemental phosphate to enhance PTH secretion. Fourteen weeks after the start of phosphate supplementation, half of the Nx and Sham dogs received doses of OCT (three times per week); the other half were given vehicle for 60 weeks. Thereafter, the treatment modalities for a subset of animals were crossed over for an additional eight months. Biochemical and hormonal indices of calcium and bone metabolism were measured throughout the study, and bone biopsies were done at baseline, 60 weeks after OCT or vehicle treatment, and at the end of the crossover period. RESULTS: In Nx dogs, OCT significantly decreased serum PTH levels soon after the induction of renal insufficiency. In long-standing secondary hyperparathyroidism, OCT (0.03 microg/kg) stabilized serum PTH levels during the first months. Serum PTH levels rose thereafter, but the rise was less pronounced compared with baseline than the rise seen in Nx control. These effects were accompanied by episodes of hypercalcemia and hyperphosphatemia. In animals with normal renal function, OCT induced a transient decrease in serum PTH levels at a dose of 0.1 microg/kg, which was not sustained with lowering of the doses. In Nx dogs, OCT reversed abnormal bone formation, such as woven osteoid and fibrosis, but did not significantly alter the level of bone turnover. In addition, OCT improved mineralization lag time, (that is, the rate at which osteoid mineralizes) in both Nx and Sham dogs. CONCLUSIONS: These results indicate that even though OCT does not completely prevent the occurrence of hypercalcemia in experimental dogs with renal insufficiency, it may be of use in the management of secondary hyperparathyroidism because it does not induce low bone turnover and, therefore, does not increase the risk of adynamic bone disease. (+info)
Serum levels of 1,25-dihydroxyvitamin D, 24,25-dihydroxyvitamin D, and 25-hydroxyvitamin D in nondialyzed patients with chronic renal failure. (3/2474)BACKGROUND: In patients with chronic renal failure (CRF), abnormalities in vitamin D metabolism are known to be present, and several factors could contribute to the abnormalities. METHODS: We measured serum levels of three vitamin D metabolites, 1,25(OH)2D, 24, 25(OH)2D and 25(OH)D, and analyzed factors affecting their levels in 76 nondialyzed patients with CRF (serum creatinine> 1.6 and < 9.0 mg/dl), 37 of whom had diabetes mellitus (DM-CRF) and 39 of whom were nondiabetic (nonDM-CRF). RESULTS: Serum levels of 1,25(OH)2D were positively correlated with estimated creatinine clearance (CCr; r = 0.429; P < 0.0001), and levels of 24,25(OH)2D were weakly correlated with CCr (r = 0.252, P < 0.05); no correlation was noted for 25(OH)D. Serum levels of all three vitamin D metabolites were significantly and positively correlated with serum albumin. Although there were no significant differences in age, sex, estimated CCr, calcium and phosphate between DM-CRF and nonDM-CRF, all three vitamin D metabolites were significantly lower in DM-CRF than in nonDM-CRF. To analyze factors influencing vitamin D metabolite levels, we performed multiple regression analyses. Serum 25(OH)D levels were significantly and independently associated with serum albumin, presence of DM and serum phosphate (R2 = 0.599; P < 0.0001). 24,25(OH)2D levels were significantly and strongly associated with 25(OH)D (beta = 0.772; R2 = 0.446; P < 0.0001). Serum 1,25(OH)2D levels were significantly associated only with estimated CCr (R2 = 0. 409; P < 0.0001). CONCLUSIONS: These results suggest that hypoalbuminemia and the presence of DM independently affect serum 25(OH)D levels, probably via diabetic nephropathy and poor nutritional status associated with diabetes, and that 25(OH)D is actively catalyzed to 24,25(OH)2D in CRF, probably largely via extrarenal 24-hydroxylase. Serum levels of 1,25(OH)2D were significantly affected by the degree of renal failure. Thus, this study indicates that patients with CRF, particularly those with DM, should receive supplements containing the active form of vitamin D prior to dialysis. (+info)
1,25-Dihydroxyvitamin D3 enhances the susceptibility of breast cancer cells to doxorubicin-induced oxidative damage. (4/2474)1,25-Dihydroxyvitamin D3 (1,25(OH)2D3), the hormonal form of vitamin D, has anticancer activity in vivo and in vitro. Doxorubicin exerts its cytotoxic effect on tumor cells mainly by two mechanisms: (a) generation of reactive oxygen species (ROS); and (b) inhibition of topoisomerase II. We studied the combined cytotoxic action of 1,25(OH)2D3 and doxorubicin on MCF-7 breast cancer cells. Pretreatement with 1,25(OH)2D3 resulted in enhanced cytotoxicity of doxorubicin. The average enhancing effect after a 72-h pretreatment with 1,25(OH)2D3 (10 nM) followed by a 24-h treatment with 1 microg/ml doxorubicin was 74+/-9% (mean +/- SE). Under these experimental conditions, 1,25(OH)2D3 on its own did not affect cell number or viability. 1,25(OH)2D3 also enhanced the cytotoxic activity of another ROS generating quinone, menadione, but did not affect cytotoxicity induced by the topoisomerase inhibitor etoposide. The antioxidant N-acetylcysteine slightly reduced the cytotoxic activity of doxorubicin but had a marked protective effect against the combined action of 1,25(OH)2D3 and doxorubicin. These results indicate that ROS are involved in the interaction between 1,25(OH)2D3 and doxorubicin. 1,25(OH)2D3 also increased doxorubicin cytotoxicity in primary cultures of rat cardiomyocytes. Treatment of MCF-7 cells with 1,25(OH)2D3 alone markedly reduced the activity, protein, and mRNA levels of the cytoplasmic antioxidant enzyme Cu/Zn superoxide dismutase, which indicated that the hormone inhibits its biosynthesis. This reduction in the antioxidant capacity of the cells could account for the synergistic interaction between 1,25(OH)2D3 and doxorubicin and may also suggest increased efficacy of 1,25(OH)2D3 or its analogues in combination with other ROS-generating anticancer therapeutic modalities. (+info)
Convergence of transforming growth factor-beta and vitamin D signaling pathways on SMAD transcriptional coactivators. (5/2474)Cell proliferation and differentiation are regulated by growth regulatory factors such as transforming growth factor-beta (TGF-beta) and the liphophilic hormone vitamin D. TGF-beta causes activation of SMAD proteins acting as coactivators or transcription factors in the nucleus. Vitamin D controls transcription of target genes through the vitamin D receptor (VDR). Smad3, one of the SMAD proteins downstream in the TGF-beta signaling pathway, was found in mammalian cells to act as a coactivator specific for ligand-induced transactivation of VDR by forming a complex with a member of the steroid receptor coactivator-1 protein family in the nucleus. Thus, Smad3 may mediate cross-talk between vitamin D and TGF-beta signaling pathways. (+info)
Regulation of PiT-1, a sodium-dependent phosphate co-transporter in rat parathyroid glands. (6/2474)A cDNA encoding an Na+-Pi co-transporter, termed rat PiT-1, has now been isolated from rat parathyroid. Expression of rat PiT-1 in Xenopus oocytes revealed that it possesses Na+-dependent Pi co-transport activity. The amount of PiT-1 mRNA in the parathyroid of vitamin D-deficient rats was reduced compared with that in normal animals, and increased markedly after administration of 1,25-dihydroxyvitamin D3. Furthermore, the abundance of PiT-1 mRNA in the parathyroid was much greater in rats fed a low-Pi diet than in those fed a high-Pi diet. Thus, rat PiT-1 may contribute to the effects of Pi and vitamin D on parathyroid function. (+info)
Regulation of vitamin D action. (7/2474)The control of gene transcription by vitamin D compounds is initiated by binding to the VDR, which enhances the receptor's ability to heterodimerize to RXR, interact with response elements in target genes and attract components of the transcriptional initiation complex. A number of factors are capable of influencing this process, including (i) the rate of uptake and catabolism of the ligand, (ii) the nature of the conformational change induced by a specific ligand, (iii) the cellular content of the VDR, (iv) post-translational modifications of the VDR and (v) the availability of other transcriptional components. Vitamin D analogues may affect these factors differently to 1,25(OH)2D3 to produce unique biological profiles that can be exploited for therapeutic use. (+info)
Topical psoriasis therapy. (8/2474)Psoriasis is a common dermatosis, affecting from 1 to 3 percent of the population. Until recently, the mainstays of topical therapy have been corticosteroids, tars, anthralins and keratolytics. Recently, however, vitamin D analogs, a new anthralin preparation and topical retinoids have expanded physicians' therapeutic armamentarium. These new topical therapies offer increased hope and convenience to the large patient population with psoriasis. (+info)
Direct inhibitory effect of calcitriol on parathyroid function (sigmoidal curve) in dialysis<...
TY - JOUR. T1 - Direct inhibitory effect of calcitriol on parathyroid function (sigmoidal curve) in dialysis. AU - Dunlay, R.. AU - Rodriguez, M.. AU - Felsenfeld, A. J.. AU - Llach, F.. PY - 1989/1/1. Y1 - 1989/1/1. N2 - The effect of intravenous calcitriol on parathyroid function was evaluated in nine chronic hemodialysis patients with secondary hyperparathyroidism. Two micrograms of calcitriol were administered intravenously after dialysis thrice weekly for ten weeks. Parathyroid function was assessed by inducing hypo- and hypercalcemia with low calcium (1.0 mEq/liter) and high calcium (4.0 mEq/liter) dialyses before and after ten weeks of intravenous calcitriol therapy. To avoid hypercalcemia during calcitriol administration, the dialysate calcium was reduced to 2.5 mEq/liter. Parathyroid hormone (PTH) values (pg/ml) from dialysis-induced hypo- and hypercalcemia were plotted against serum ionized calcium, and the sigmoidal relationship between PTH and calcium was evaluated. Basal PTH levels ...
Sequential versus combined treatment of human breast cancer cells with antiestrogens and the vitamin D analogue EB1089 and...
TY - JOUR. T1 - Sequential versus combined treatment of human breast cancer cells with antiestrogens and the vitamin D analogue EB1089 and evaluation of predictive markers for vitamin D treatment. AU - Christensen, G L. AU - Jepsen, J S. AU - Fog, C K. AU - Christensen, I J. AU - Lykkesfeldt, A E. PY - 2004/5. Y1 - 2004/5. N2 - Development of resistance to antihormonal therapy is a major problem in the treatment of breast cancer patients. Metastatic tumors, which progress after a period of response to treatment, often respond to second line endocrine treatment, but eventually develop estrogen independent growth. Vitamin D analogues are promising new drugs, using alternative mechanisms to inhibit growth of breast cancer cells. The sensitivity to antiestrogens and vitamin D analogues has been proposed to be inverse, indicating that the sensitivity to vitamin D analogues might increase after development of antiestrogen resistance and vice versa. In this study, the inverse sensitivity between ...
Comparison of the Effects of Daily and Intermittent-Dose Calcitriol on Serum Parathyroid Hormone and Ionized Calcium...
Hostutler, R. A., DiBartola, S. P., Chew, D. J., Nagode, L. A., Schenck, P. A., Rajala-Schultz, P. J. and Drost, W. T. (2006), Comparison of the Effects of Daily and Intermittent-Dose Calcitriol on Serum Parathyroid Hormone and Ionized Calcium Concentrations in Normal Cats and Cats with Chronic Renal Failure. Journal of Veterinary Internal Medicine, 20: 1307-1313. doi: 10.1111/j.1939-1676.2006.tb00743.x ...
1,25 Dihydroxyvitamin D circulating levels, calcitriol administration, and incidence of acute rejection, CMV infection, and...
1,25 Dihydroxyvitamin D circulating levels, calcitriol administration, and incidence of acute rejection, CMV infection, and polyoma virus infection in renal transplant recipients ...
Enhancement of vasoconstrictor response by a noncalcemic analogue of vitamin D3. | Hypertension
To clarify the effects of active vitamin D3 on pressor and vascular responses to vasoconstrictor substances, we studied pressor responses to the intravenous injection of norepinephrine or angiotensin II (Ang II) and vasoconstrictor responses to norepinephrine. Sprague-Dawley rats were given 1,25-dihydroxyvitamin D3 subcutaneously (200 ng/kg per day) for 14 days. The administration of 1,25-dihydroxyvitamin D3 augmented the pressor responses to norepinephrine and Ang II in conscious rats and was associated with a significant increase in serum calcium concentration (11.0 +/- 0.2 mg/dl). To further clarify whether the increased pressor response to vasoconstrictors may be due to the calcemic or direct action of active vitamin D3, we studied the effect of its noncalcemic analogue, 22-oxacalcitriol, and its inactive analogue, 24,25-dihydroxyvitamin D3, on the pressor response to vasoconstrictors in rats. The pressor responses to norepinephrine and Ang II were apparently augmented in ...
Calcitriol Plus Dexamethasone in Treating Patients With Prostate Cancer That Has Not Responded to Hormone Therapy - Full Text...
OUTLINE: This is a dose-escalation study of calcitriol.. In the first stage of the study, cohorts of 3-6 patients receive escalating doses of oral calcitriol on days 1-3. Dose escalation continues until the maximum tolerated dose (MTD) is determined.. In the second stage, patients receive escalating doses of oral calcitriol on days 1-3 and a fixed dose of oral dexamethasone on days 0-4. Treatment continues weekly in the absence of disease progression or unacceptable toxicity. Dose escalation continues until the MTD is determined.. Six additional patients may receive calcitriol and dexamethasone at one dose level below the MTD determined in the second stage, to confirm the MTD.. The MTD is defined as the dose preceding that at which 2 of 3 or 2 of 6 patients experience dose-limiting toxicity.. PROJECTED ACCRUAL: Approximately 40 patients will be accrued for this study. ...
23,25-Dihydroxyvitamin D3: a natural precursor in the biosynthesis of 25-hydroxyvitamin D3-26,23-lactone | PNAS
To elucidate the biosynthesis of 25-hydroxyvitamin D3-26,23-lactone, two known metabolites of 25-hydroxyvitamin D3--23,25-dihydroxyvitamin D3 and 25,26-dihydroxyvitamin D3--were incubated individually with kidney homogenate prepared from vitamin D-supplemented chickens, a preparation known to produce the lactone from 25-hydroxyvitamin D3. The 25-hydroxyvitamin D3-26,23-lactone produced in vitro was then separated, purified, identified, and quantitated by consecutive straight-phase and reverse-phase high-performance liquid chromatography. 23,25-Dihydroxyvitamin D3 is a far better substrate for production of 25-hydroxyvitamin D3-26,23-lactone than is 25,26-dihydroxyvitamin D3. Production of lactone is highly selective for the natural 23(S)-hydroxy-23,25-dihydroxyvitamin D3 while both epimers of 25,26-dihydroxyvitamin D3 resulted in small amounts of product comigrating with natural lactone. It appears that 23(S),25-dihydroxyvitamin D3, but not 25,26-dihydroxyvitamin D3, is a natural precursor in ...
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ASCENT: Androgen Independent Prostate Cancer Study of Calcitriol Enhancing Taxotere - Full Text View - ClinicalTrials.gov
DN-101 is an investigational drug that has not been approved by the U.S. Food and Drug Administration (FDA). It is a newly formulated pill that contains high amounts of calcitriol, a naturally occurring hormone and the biologically active form of vitamin D. Administration of DN-101 results in much higher blood levels of calcitriol than the body can produce from dietary vitamin D or vitamin D supplements. These higher levels of calcitriol are associated with anti-cancer effects in laboratory models of human cancer. Laboratory models also indicate that calcitriol has synergy with many commonly used chemotherapeutic agents used to treat cancer.. Calcitriol, at very low doses, is currently approved for use in patients with chronic kidney failure. DN-101 was specifically designed for cancer and contains 30 times the amount of calcitriol found in the calcitriol pill commercially available today. In order to take an amount of calcitriol equivalent to 1 DN-101 pill, cancer patients would need to swallow ...
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The mechanism of action of calcitriol in the treatment of psoriasis is accounted for by their antiproliferative activity for keratinocytes and their stimulation of epidermal cell differentiation. The anticarcinogenic activity of the active form of Calcitriol appears to be correlated with cellular vitamin D receptor (VDR) levels. Vitamin D receptors belong to the superfamily of steroid-hormone zinc-finger receptors. VDRs selectively bind 1,25-(OH)2-D3 and retinoic acid X receptor (RXR) to form a heterodimeric complex that interacts with specific DNA sequences known as vitamin D-responsive elements. VDRs are ligand-activated transcription factors. The receptors activate or repress the transcription of target genes upon binding their respective ligands. It is thought that the anticarcinogenic effect of Calcitriol is mediated via VDRs in cancer cells. The immunomodulatory activity of calcitriol is thought to be mediated by vitamin D receptors (VDRs) which are expressed constitutively in monocytes ...
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Effects of Cinacalcet and Concurrent Low-Dose Vitamin D on FGF23 Levels in ESRD | American Society of Nephrology
Ongoing studies are attempting to determine the optimal combination of calcimimetics and calcitriol analogs for the treatment of SHPT. The ACHIEVE study recently compared the effects of Cinacalcet plus fixed low-dose calcitriol analogs with flexible doses of calcitriol analogs on PTH, Ca, and P levels (25). In this study, we used samples from ACHIEVE to perform a per-protocol analysis of the effects of treatment on FGF23, a factor associated with poor outcomes in ESRD (15). We found that the treatment regimen using Cinacalcet plus fixed low-dose calcitriol analogs results in a relative decrease in FGF23 levels compared with an approach using escalating doses of calcitriol analogs alone. This study is the first report of the disparate effects of different treatment strategies on FGF23 levels in HD patients.. The existence of complex interactions between treatment agents and mineral metabolic parameters make it difficult to ascribe the observed differences in FGF23 to a specific therapeutic ...
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Effect of calcitriol on the production of T-cell-derived cytokines in psoriasis
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The in vitro evaluation of 25-hydroxyvitamin D<sub>3</sub> and 19-nor-1α,25- dihydroxyvitamin D<sub>2</sub> as therapeutic...
TY - JOUR. T1 - The in vitro evaluation of 25-hydroxyvitamin D3 and 19-nor-1α,25- dihydroxyvitamin D2 as therapeutic agents for prostate cancer. AU - Chen, Tai C.. AU - Schwartz, Gary G.. AU - Burnstein, Kerry L.. AU - Lokeshwar, Bal L.. AU - Holick, Michael F.. PY - 2000/3/1. Y1 - 2000/3/1. N2 - Prostate cancer cells contain specific receptors [vitamin D receptors (VDRs)] for 1α,25-dihydroxyvitamin D3 (1α,25(OH)2D3), which is known to inhibit the proliferation and invasiveness of these cells. These findings support the use of 1α,25(OH)2D3 for prostate cancer therapy. However, because 1α,25(OH)2D3 can cause hypercalcemia, analogues of 1α,25(OH)2D3 that are less calcemic but that exhibit potent antiproliferative activity would be attractive as therapeutic agents. We investigated the effects of two different types of less calcemic vitamin D compounds, 25-hydroxyvitamin D3 [25(OH)D3] and 19-nor-1α,25-dihydroxyvitamin D2 [19-nor-1,25(OH)2D2], and compared their activity to 1α,25(OH)2D3 on ...
Association of Oral Calcitriol with Improved Survival in Nondialyzed CKD | American Society of Nephrology
We observed an association of oral calcitriol with lower mortality among adults with stages 3 to 4 CKD and hyperparathyroidism, independent of measured comorbidity, kidney function, and serum PTH levels. Associations were statistically similar according to baseline PTH level, eGFR, and diabetes status, although stratified analyses were limited by sample size. These are among the first data to describe clinical outcomes associated with oral activated vitamin D agents in nondialysis patients with CKD.. There is biologic plausibility for an association of calcitriol use with lower mortality. Vitamin D is a pleiotropic steroid hormone that binds to its intracellular receptor to elicit a diverse genetic response.12 Experimental and epidemiologic studies have connected lower 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D levels with cardiovascular risk factors, including increased renin activity, hypertension, inflammation, insulin resistance, diabetes, and albuminuria.14,22-24 Calcitriol blocks ...
Hormonally active agents in the environment: a state-of-the-art review : Reviews on Environmental Health
AbstractAfter the Second World War, infatuation with modern products has exponentially widened the spectrum of chemicals used. Some of them are capable of hijacking the endocrine system by blocking or imitating a hormone and are referred to as hormonally active chemicals or endocrine disruptors. These are chemicals that the body was not designed for evolutionarily and they are present in every matrix of the environment. We are living in a chemical world where the exposures are ubiquitous and take place in combinations that can interact with the endocrine system and some other metabolic activities in unexpected ways. The complexity of interaction of these compounds can be understood by the fact that they interfere with gene expression at extremely low levels, consequently harming an individual life form, its offspring or population. As the endocrine system plays a critical role in many biological or physiological functions, by interfering bodys endocrine system, endocrine disrupting compounds (EDCs)
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There is a close correlation between treatment with calcitriol and the development of hypercalcemia.. All other vitamin D compounds and their derivative, including proprietary compounds or foodstuffs which may be fortified with vitamin D, should be withheld during treatment with calcitriol.. An abrupt increase in calcium intake as a result of changes in diet (e.g. increased consumption of dairy products) or uncontrolled intake of calcium preparations may trigger hypercalcaemia. Patients and their families should be advised that strict adherence to the prescribed diet is mandatory and they should be instructed on how to recognise the symptoms of hypercalcaemia.. As soon as the serum calcium levels rise to 1 mg/100 ml (250 pmol/l) above normal (9-11 mg/100 ml, or 2250-2750 pmol/l), or serum creatinine rises to , 120 pmol/l, treatment with calcitriol should be stopped immediately until normocalcemia ensues.(see section 4.2). Immobilized patients, e.g. those who have undergone surgery, are ...
Its been proposed that cellular Ca2+ signals activate hormone secretion. polypeptide | Selective Inhibitors of Protein...
Its been proposed that cellular Ca2+ signals activate hormone secretion. polypeptide with two EF-calcium-binding sites that are usually expressed in the mammalian intestine, uterus, and pituitary gland. The major role of this protein is buffering of Ca2+ ions . The discovery of a high affinity receptor in the pancreas for the hormonally active form of vitamin D, 1,25-dihydroxyvitamin D3 (1,25(OH)2D3), in 1979 was the first demonstration of a nonclassical target tissue to contain vitamin D receptors (VDR) . Impaired insulin secretory capacity in pancreatic cells was also observed in mice lacking a functional VDR . 1,25(OH)2D3 and its cognitive VDR regulate many target genes, including CaBP-9k. The expression of CaBP-9k has been shown to be mediated by vitamin D response element (VDRE) on its promoter. CaBP-9k regulates the amount of intracellular calcium to prevent cell death from reaching the toxicity of free calcium . Calcium signaling in all secretory cells (nerve cell, endocrine ...
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Calcitriol - DrugBank
Calcitriol or 1,25-dihydroxycholecalciferol (abbreviated 1,25-(OH)2-D3) is the active form of vitamin D found in the body (vitamin D3). Calcitriol is marketed under various trade names including Rocaltrol (Roche), Calcijex (Abbott) and Decostriol (Mibe, Jesalis). It is produced in the kidneys via 25-hydroxyvitamin D-1 α-hydroxylase by conversion from 25-hydroxycholecalciferol (calcidiol). This is stimulated by a decrease in serum calcium, phosphate (PO43−) and parathyroid hormone (PTH) levels. It regulates calcium levels by increasing the absorption of calcium and phosphate from the gastrointestinal tract, increasing calcium and phosphate reabsorption in the kidneys and inhibiting the release of PTH. Calcitriol is also commonly used as a medication in the treatment of hypocalcemia and osteoporosis.
Calcitriol Receptors - Calcitriol Receptor Summary Report | CureHunter
Calcitriol Receptors: Proteins, usually found in the cytoplasm, that specifically bind calcitriol, migrate to the nucleus, and regulate transcription of specific segments of DNA with the participation of D receptor interacting proteins (called DRIP). Vitamin D is converted in the liver and kidney to calcitriol and ultimately acts through these receptors.
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Calcitriol will work only if you get the right amount of calcium from the foods you eat. If you get too much calcium from foods, you may experience serious side effects of calcitriol, and if you do not get enough calcium from foods, calcitriol will not control your condition. Your doctor will tell you which foods are good sources of these nutrients and how many servings you need each day. If you find it difficult to eat enough of these foods, tell your doctor. In that case, your doctor can prescribe or recommend a supplement.. If you are being treated with dialysis (process of cleaning the blood by passing it through a machine), your doctor may also prescribe a low-phosphate diet. Follow these directions carefully.. If you do not have kidney disease, you should drink plenty of fluids while taking calcitriol. If you have kidney disease, talk to your doctor about how much fluid you should drink each day.. ...
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Calcitriol will work only if you get the right amount of calcium from the foods you eat. If you get too much calcium from foods, you may experience serious side effects of calcitriol, and if you do not get enough calcium from foods, calcitriol will not control your condition. Your doctor will tell you which foods are good sources of these nutrients and how many servings you need each day. If you find it difficult to eat enough of these foods, tell your doctor. In that case, your doctor can prescribe or recommend a supplement.. If you are being treated with dialysis (process of cleaning the blood by passing it through a machine), your doctor may also prescribe a low-phosphate diet. Follow these directions carefully.. If you do not have kidney disease, you should drink plenty of fluids while taking calcitriol. If you have kidney disease, talk to your doctor about how much fluid you should drink each day.. ...
Global Calcitriol (CAS 32222-06-3) Market 2017: By Manufacturers, Regions, Type and Application, Forecast to 2022 | Business
Before Its News). Market Research Store has been recently published a fresh research report- Global Calcitriol (CAS 32222-06-3) Market by Manufacturers, Countries, Type and Application, Forecast to 2022 . This added to the companys collection of research reports. This report offers a deep examination of the Calcitriol market for the period 2013-2023. As per the report, the Calcitriol market is estimated to grow at elevated CAGR recorded in 2017. The towering competitive Calcitriol market has been observing huge and whooping investments in development and research from government as well as private firms.. This report divides the market on the basis of regions, manufacturers, application, and type. It also showcases the growing factors, reasons for decline in the market, segmentations, and openings and breaks expected to power the market expansion during this time span. The primary factors such as revenues, supply chain management, product valuation and other crucial factors are also examined ...
63] A Sensitive Radioreceptor Assay for 1α,25-Dihydroxyvitamin D in Biological Fluid<...
TY - JOUR. T1 -  A Sensitive Radioreceptor Assay for 1α,25-Dihydroxyvitamin D in Biological Fluid. AU - Chandler, John S.. AU - Wesley Pike, J.. AU - Hagan, Laura A.. AU - Haussler, Mark R.. PY - 1980/1/1. Y1 - 1980/1/1. N2 - This chapter discusses a sensitive radioreceptor assay for lα,25-dihydroxyvitamin D in biological fluids. Vitamin D has been recognized as a principal regulator of calcium and phosphate homeostasis in a variety of animal species, including humans. Some studies describe 1α,25-dihydroxyvitamin D [lα,25-(OH)2D] as the hormonal metabolite responsible for mediating intestinal transport of these minerals and hence necessitate development of a precise method for quantitating this sterol in biological fluids, particularly serum. It has been demonstrated that chick intestinal mucosa contained a cytosolic protein that rapidly and specifically bound lα,25-(OH)2D3 both in vivo and in vitro with high affinity. Furthermore, the sterol-protein complex was rapidly translocated to ...
Electromechanical effects of 1,25-dihydroxyvitamin D with antiatrial fibrillation activities<...
TY - JOUR. T1 - Electromechanical effects of 1,25-dihydroxyvitamin D with antiatrial fibrillation activities. AU - Hanafy, Dicky A.. AU - Chang, Shih Lin. AU - Lu, Yen Yu. AU - Chen, Yao Chang. AU - Kao, Yu Hsun. AU - Huang, Jen Hung. AU - Chen, Shih Ann. AU - Chen, Yi Jen. PY - 2014. Y1 - 2014. N2 - Electromechanical Effects of 1,25-Dihydroxyvitamin D on the LA Introduction Treatment with 1,25-dihydroxyvitamin D (1,25[OH]2D) has several cardiovascular benefits. 1,25[OH]2D has direct cellular effects, but its effects on the atrium are not clear. We evaluated the effects of 1,25[OH]2D on the atrial electrophysiology and atrial fibrillation (AF). Methods Conventional microelectrodes were used to record action potentials (APs) and contractility in isolated rabbit left atrium (LA) tissue preparations before and after the administration of 0.01, 0.1, and 1 nM 1,25[OH] 2D with and without rapid atrial pacing (RAP) and acetylcholine (5 mM)-induced AF. Surface ECG and intracardiac electrograms were ...
Total synthesis of 1α,25-dihydroxyvitamin D3 (calcitriol) through a Si-assisted allylic substitution - Chemical Communications ...
Herein, we describe a versatile and efficient total synthesis of 1α,25-dihydroxyvitamin D3 (calcitriol). The synthetic strategy relies on an unprecedented Si-assisted SN2′-syn displacement of carbamates by cuprates to set the challenging pivotal quaternary methyl group at the fused-ring junction of the CD-tr
The Potential Role of Calcitriol Analogs in the Management of Breast Cancer.
Breast cancer is the second leading cause of cancer deaths among females and a leading cause of death of all middle age women in the United States. Epidemiologic evidence suggests a role for vitamin D deficiency in the development of breast cancer. Moreover, vitamin D receptors have been found in most breast cancers, and their presence appears to be a favorable prognostic sign. While much clinical focus has been given to the vitamin A related retinoids, little is known about the role for vitamin D in the development of breast cancer although vitamin D and its active metabolites and analogs represent a class of compounds which at the molecular and cellular level have strong similarities to the vitamin A metabolites and analogs. With the development of potent but non hypercalcemic analogs of vitamin D, the potential role of vitamin D in the etiology and treatment of breast cancer can now be tested both in vitro and in vivo. In the past decade, a number of tissues have been found to contain receptors for
Calcitriol - Dog
Calcitriol (ergocalciferol, 1,25-dihydroxycholecalciferol, 1,25-dihydroxyvitamin D3) is a synthetic form of vitamin D. Calcitriol causes increased calcium absorption from the gut. This product is used for treatment of hypocalcemia associated with rickets and hypoparathyroidism. Regular monitoring of blood calcium is important to avoid development of hypercalcemia. Recommended dose in dogs is 25,000 - 50,000 U/day given orally. ...
Generation of inositol phosphates, diacylglycerol and calcium fluxes in myoblasts treated with 1,25-dihydroxyvitamin D3 |...
We have examined the effects of the seco-steroid hormone 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] on membrane phosphoinositide metabolism, protein kinase C (PKC) activation and influx of extracellular Ca2+ in chick-embryo muscle-cell (myoblast) cultures. At physiological concentrations, the hormone induces a rapid (15 s) and transient release of inositol triphosphate (InsP3) and diacylglycerol (DAG). InsP3 release is maximal at 60 s (80% above controls) and then declines. The effects of 1,25(OH)2D3 on InsP3 production exhibited specificity, as 25-hydroxy-vitamin D3 and 24,25-dihydroxy-vitamin D3 did not alter myoblast InsP3 levels. The stimulation of DAG is biphasic, with peaks at 60 s (+105%) and 5 min (+700%). The second phase of DAG release is not associated with changes in InsP3. 1,25(OH)2D3 induces a rapid (within 60 s) accumulation of InsP2, and its effect on InsP is delayed (120 s). The hormone rapidly activates myoblast PKC, with maximal translocation of activity from the cytosol to the ...
Biological activity of 1 alpha, 25-dihydroxyvitamin D derivatives--24-epi-1 alpha, 25-dihydroxyvitamin D-2 and 1 alpha,25...
Biological activity of 1 alpha, 25-dihydroxyvitamin D derivatives--24-epi-1 alpha, 25-dihydroxyvitamin D-2 and 1 alpha,25-dihydroxyvitamin D-7. Biochim Biophys Acta. 1991 Jan 31; 1091(2):188-92 ...
Phase I study of weekly DN-101, a new formulation of calcitriol, in patients with cancer<...
TY - JOUR. T1 - Phase I study of weekly DN-101, a new formulation of calcitriol, in patients with cancer. AU - Beer, Tomasz (Tom). AU - Javle, Milind M.. AU - Ryan, Christopher. AU - Garzotto, Mark. AU - Lam, Gilbert N.. AU - Wong, Alvin. AU - Henner, W. David. AU - Johnson, Candace S.. AU - Trump, Donald L.. PY - 2007/4. Y1 - 2007/4. N2 - Background: DN-101 is a new, high-dose, oral formulation of calcitriol under investigation for the treatment of cancer. We sought to evaluate the tolerability and pharmacokinetics (PK) of weekly doses of DN-101 in patients with advanced cancer. Methods: Patients who completed a previously reported single dose escalation study of DN-101 [Beer et al. (2005) Clin Cancer Res 11:7794-7799] were eligible for this continuation weekly dosing study. Cohorts of 3-10 patients were treated at doses of 15, 30, 45, 60, and 75 μg calcitriol. Once 45 μg was established as the maximum tolerated dose (MTD), this cohort was expanded to include 18 patients. Dose limiting ...
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Sunshine hormone, vitamin D, may offer hope for treating liver fibrosis - Salk Institute for Biological Studies
Because there are currently no effective drugs for liver fibrosis, we believe our findings would open a new door for treatment, says senior author Ronald M. Evans, a professor in Salks Gene Expression Laboratory and lead researcher in the Institutes new Helmsley Center for Genomic Medicine. The Salk study focused on a star-shaped stellate cell in the liver that serves as a beacon for damage. When called into action, stellate cells produce fibrotic proteins in an attempt to heal an injury. Under chronic stress, however, localized fibrosis expands, eventually leading to cirrhosis, increased risk of liver cancer, and the need for a liver transplant in advanced cases. The Evans lab discovered a genetic switch through which vitamin D-related ligands such as calcitriol, a hormonally active form of the vitamin, can put the brakes on fibrosis. Preclinical results suggest the vitamin D brake is highly efficacious and led us to believe that the time is right to consider a trial in the context of ...
1,25-Dihydroxyvitamin D<sub>3</sub>-induced alterations of lipid metabolism in human monocyte...
TY - JOUR. T1 - 1,25-Dihydroxyvitamin D3-induced alterations of lipid metabolism in human monocyte-macrophages. AU - Roullet, J. B.. AU - Haluska, M.. AU - Morchoisne, O.. AU - McCarron, D. A.. PY - 1989/1/1. Y1 - 1989/1/1. N2 - An in vivo atherogenic role of dietary vitamin D has been postulated. To address this hypothesis we sought to determine the in vitro effects of its active circulating metabolite, 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] on lipid metabolism in human monocyte-derived macrophages. When cultured 6 days in the presence of 10-8 M 1,25(OH)2D3 monocyte-macrophage accumulated significantly more triglycerides than control cells: 987.6 ± 26.8 vs. 779.3 ± 24.1 μg/mg protein (P , 0.001). Triglyceride accumulation was associated with a hormone-induced stimulation of triglyceride synthesis as determined by [3H]oleate incorporation into cellular triglycerides. The effect of the hormone was significant after 24 h and dose dependent [10-11 to 10-8 M 1,25(OH)2D3]. It was specific since ...
C-terminal proteolysis of the avian 1,25-dihydroxyvitamin D<sub>3</sub>...
TY - JOUR. T1 - C-terminal proteolysis of the avian 1,25-dihydroxyvitamin D3 receptor. AU - Allegretto, Elizabeth A.. AU - Pike, J. Wesley. AU - Haussler, Mark R.. PY - 1987/8/31. Y1 - 1987/8/31. N2 - Exposure of the 60 kDa chick intestinal 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) receptor to carboxypeptidase A resulted in a time dependent decrease in receptor hormone-binding; after 2 h, there was no detectable macro-molecular-bound 1,25(OH)2[3H]D3. Upon DNA-cellulose chromatography of this preparation, a 56 kDa protein adsorbed to the column and eluted as a function of para-chloromercuribenzene sulfonate (a sulfhydryl blocking reagent). The 56 kDa fragment was detected by anti-receptor monoclonal antibodies via immunoblot technology. The 1,25(OH)2[3H]D3 eluted in the fall through fractions of the column. Thus, cleavage of up to 40 amino acids from the carboxy-terminus of the 1,25(OH)2D3 receptor results in a protein which no longer binds to hormone, but retains its capacity to interact with ...
Renal function during calcitriol therapy in chronic renal failure
Some authors have reported that vitamin D treatment worsens renal function. We studied 10 patients with stable renal function, who were given calcitriol (0.5 micrograms/day) for a 4-month period. Creatinine and inulin clearance were performed at the beginning and at the end of the treatment. Althoug …
calcitriol (vitamin D3) | PeaceHealth
Calcitriol is vitamin D3. Vitamin D is important for the absorption of calcium from the stomach and for the functioning of calcium in the body. Calcitriol is used to treat hyperparathyroidism (overactive parathyroid glands) and metabolic bone disease in people who have chronic kidney failure and are not receiving...
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Calcitriol-a treatment for chronic kidney failure in your cat or dog. Calcitriol as the active form of Vitamin D is actually a hormone over 1,000 times as potent ...
Avet announces launch of Calcitriol soft gel capsules - Avet Pharmaceuticals Inc.
Avet Pharmaceuticals Inc. announced the immediate availability of Calcitriol soft gel capsules in 0.25 and 0.5 mcg strengths. This product is the AB rated generic equivalent to the synthetic Vitamin D drug Rocaltrol®* and adds to Avets robust portfolio of generic oral soft gel products. According to IMS data for the twelve-months ended April 2013, the U.S. market for Calcitriol approximated $60 million. *Rocaltrol is a registered trademark of Hoff-mann LaRoche-Validus.. Download Press Release. ...
CD22 | FLT3 tyrosine kinase inhibitors in acute myeloid leukemia
Calcitriol (1,25-dihydroxyvitamin D3), the hormonally dynamic type of vitamin D, inhibits the development of several malignant cells including breasts tumor (BCa) cells. estrogens. Therefore the inhibition of estrogen synthesis and signaling by calcitriol and its own 162011-90-7 manufacture anti-inflammatory activities will play a significant part in inhibiting ER+ BCa. We hypothesize that diet supplement D would display very similar anticancer activity because of the presence from the enzyme 25-hydroxyvitamin D-1-hydroxylase (CYP27B1) in breasts cells ensuring transformation of circulating 25-hydroxyvitamin D to calcitriol locally inside the breasts micro-environment where it could act within a paracrine way to inhibit BCa development. Cell lifestyle and in vivo data in mice highly claim that calcitriol and eating supplement D would play an advantageous function in the avoidance and/or treatment of ER+ BCa in females. category of genes [7,27] and in various other BCa cells potentiates the ...
Mapping Variation in Cellular and Transcriptional Response to 1,25-Dihydroxyvitamin D3 in Peripheral Blood Mononuclear Cells.
The active hormonal form of vitamin D, 1,25-dihydroxyvitamin D (1,25D) is an important modulator of the immune system, inhibiting cellular proliferation and regulating transcription of immune response genes. In order to characterize the genetic basis of variation in the immunomodulatory effects of 1,25D, we mapped quantitative traits of 1,25D response at both the cellular and the transcriptional level. We carried out a genome-wide association scan of percent inhibition of cell proliferation (Imax) induced by 1,25D treatment of peripheral blood mononuclear cells from 88 healthy African-American individuals. Two genome-wide significant variants were identified: rs1893662 in a gene desert on chromosome 18 (p = 2.32 x 10−8) and rs6451692 on chromosome 5 (p = 2.55 x 10−8), which may influence the anti-proliferative activity of 1,25D by regulating the expression of nearby genes such as the chemokine gene, CCL28, and the translation initiation gene, PAIP1. We also identified 8 expression ...
Calcitriol | Best On Health
Calcitriol: Calcitriol stimulates intestinal absorption of calcium and accounts for supplementing calcium levels in management of postmenopausal osteoporosis.
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Effect of calcitriol on bone loss after cardiac or lung transplantation<...
TY - JOUR. T1 - Effect of calcitriol on bone loss after cardiac or lung transplantation. AU - Sambrook, Philip. AU - Henderson, N. Kathy. AU - Keogh, Anne. AU - MacDonald, Peter. AU - Glanville, Allan. AU - Spratt, Phillip. AU - Bergin, Peter. AU - Ebeling, Peter. AU - Eisman, John. PY - 2000/1/1. Y1 - 2000/1/1. N2 - Rapid bone loss after cardiac and lung transplantation results in an increased risk of osteoporotic fracture. This study examined the efficacy of treatment with calcitriol (1,25-dihydroxyvitamin D3) in preventing bone loss in patients undergoing cardiac or lung transplantation. In this 2-year double-blind, stratified study, 65 patients undergoing cardiac or single lung transplantation were randomly allocated to receive either placebo or calcitriol (0.5-0.75 μg/day), the latter for either 12 months or 24 months. All patients received 600 mg calcium/day. Bone mineral density (BMD) was measured every 6 months for 2 years by dual-energy X-ray absorptiometry. There was no significant ...
Treatment of secondary hyperparathyroidism with vitamin D derivatives and calcimimetics before and after start of dialysis :...
Chronic renal failure is almost always associated with secondary uraemic hyperparathyroidism. Action should be taken as early as possible to avoid it or reduce its severity in patients with chronic kidney disease (CKD). Over the last decade, the most effective way of achieving this has been defined as therapy with active vitamin D derivatives. However, the so‐called non‐hypercalcaemic vitamin D derivatives, which are said to be superior, have not met our expectations so far. In contrast, calcimimetic agents, the new class of compounds that act specifically on the calcium‐sensing receptor, are very promising for the treatment and prevention of hyperparathyroidism. CKD is associated with disturbances in calcium, phosphate, and vitamin D metabolism that occur early in the course of renal disease. In most patients, these disturbances lead to secondary hyperparathyroidism and osteitis fibrosa or associated, more complex, skeletal lesions. Here, we focus on recent advances in the prevention ...
Long term oral calcitriol in patients on chronic hemodialysis - ORA - Oxford University Research Archive
In a retrospective study, we have assessed the efficacy of oral calcitriol on the evolution of hyperparathyroid bone disease in patients on hemodialysis. 33 patients who had received calcitriol for at least one year and up to 7 years were carefully matched with controls for gender, years on
The vitamin D receptor is a Wnt effector that controls hair follicle differentiation and specifies tumor type in adult...
We have investigated how Wnt and vitamin D receptor signals regulate epidermal differentiation. Many epidermal genes induced by β-catenin, including the stem cell marker keratin 15, contain vitamin D response elements (VDREs) and several are induced independently of TCF/Lef. The VDR is required for β-catenin induced hair follicle formation in adult epidermis, and the vitamin D analog EB1089 synergises with β-catenin to stimulate hair differentiation. Human trichofolliculomas (hair follicle tumours) are characterized by high nuclear β-catenin and VDR, whereas infiltrative basal cell carcinomas (BCCs) have high β-catenin and low VDR levels. In mice, EB1089 prevents β-catenin induced trichofolliculomas, while in the absence of VDR β-catenin induces tumours resembling BCCs. We conclude that VDR is a TCF/Lef-independent transcriptional effector of the Wnt pathway and that vitamin D analogues have therapeutic potential in tumors with inappropriate activation of Wnt signalling.. ...
Plasma 1,25(OH)2 vitamin D measured by radioimmunoassay and cytosol radioreceptor assay in normal subjects and patients with...
Antibodies to 1 alpha, 25-dihydroxy vitamin D3 25-hemisuccinate linked to albumin were produced and an immunoassay for 1,25-dihydroxy vitamin D developed. Plasma 1,25-dihydroxy vitamin D concentrations were compared using an immunoassay and cytosol radioreceptor assay. Both assays gave comparable results but the immunoassay was more reproducible, slightly more sensitive and had a lower detection limit. Using the immunoassay the plasma 1,25-dihydroxy vitamin D was 110.5 pmol/l (S.D. 29.4) in normal subjects; there was no difference between males and premenopausal females. It was negatively related to plasma phosphate. In renal failure and primary hyperparathyroidism plasma 1,25(OH)2D was positively related to radiocalcium absorption. Following 1 and 2 microgram of 1,25-dihydroxy vitamin D3 given orally the peak plasma concentration occurs within 12 h.
Letter by Zitterman et al Regarding Article, Calcium/Vitamin D Supplementation and Cardiovascular Events | Circulation
To the Editor:. We read with interest the paper by Hsia and colleagues1 in which the authors demonstrated that a daily vitamin D supplement of 400 IU (10 μg) in combination with 1000 mg calcium has no beneficial effects on cardiovascular risk. In our opinion, the data interpretation is complicated by the lack of 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D (calcitriol) measurements. It may be that the vitamin D dose was too low to influence circulating calcitriol concentrations. It may also be that baseline 25-hydroxyvitamin D concentrations were already sufficient enough to produce adequate amounts of calcitriol. Calcitriol is the only vitamin D metabolite with known physiological actions. Experimental data demonstrate that calcitriol has important protective vascular effects such as suppression of renin activity, inhibition of vascular calcification, and reduction of thrombogenicity.2 Several retrospective studies already indicate that calcitriol and other active vitamin D analogs reduce ...
1,25-Dihydroxyvitamin D, Serum - Wyoming Medical Center
Vitamin D is a generic designation for a group of fat-soluble, structurally similar sterols including ergocalciferol D2 from plants and cholecalciferol D3 from animals. Vitamin D in the body is derived from 2 sources: exogenous (dietary: D2 and D3) and endogenous (biosynthesis: D3). Endogenous D3 is produced in the skin from 7-dehydrocholesterol, under the influence of ultraviolet light. Both forms of vitamin D are of similar biologic activity.. Vitamin D is rapidly metabolized in the liver to form 25-hydroxy (OH) vitamin D. Additional hydroxylation of 25-OH vitamin D takes place in the kidney by 1-alpha hydroxylase, under the control of parathyroid hormone, to yield 1,25-dihydroxy vitamin D.. 1,25-Dihydroxy vitamin D is the most potent vitamin D metabolite. It stimulates calcium absorption in the intestine and its production is tightly regulated through concentrations of serum calcium, phosphorus, and parathyroid hormone.. 1,25-Dihydroxy vitamin D levels may be high in primary ...
1 alpha,25-Dihydroxyvitamin D (calcitriol) inhibits the invasiveness of human prostate cancer cells. | Cancer Epidemiology,...
1 alpha,25-Dihydroxyvitamin D (1,25 D; also know as calcitriol), the hormonal form of vitamin D, can inhibit the proliferation and promote the differentiation of human prostate adenocarcinoma cells. However, little is known about the effects of 1,25 D on the invasive ability of prostate cancer cells. We used an in vitro bioassay of cell invasion (Amgel assay) to examine the effects of 1,25 D and a noncalcemic vitamin D analogue, 1,25-dihydroxy-16-ene-23-yne-cholecalciferol (16-23-D3), on the invasiveness of three well-characterized human prostate carcinoma cell lines: DU 145, PC-3, and LNCaP. PC-3 and LNCaP cells were poorly invasive in Amgel and were hardly affected by treatment with 1,25 D or 16-23-D3 (, 3%). Conversely, DU 145 cells were highly invasive in Amgel, and their invasion was markedly inhibited by 1,25 D and 16-23-D3 (maximally 66 and 59.4% respectively). This effect was both dose-dependent, with maximal inhibition at 1 x 10(-7) M and 72 h. Significant inhibition of invasion was ...
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Absorption Calcitriol is rapidly absorbed from the intestine. Peak serum concentrations (above basal values) were reached within 3 to 6 hours following oral administration of single doses of 0.25 to 1.0 mcg of Rocaltrol. Following a single oral dose of 0.5 mcg, mean serum concentrations of calcitriol rose from a baseline value of 40.0±4.4 (SD) pg/mL to 60.0±4.4 pg/mL at 2 hours, and declined to 53.0±6.9 at 4 hours, 50±7.0 at 8 hours, 44±4.6 at 12 hours, and 41.5±5.1 at 24 hours. Following multiple-dose administration, serum calcitriol levels reached steady-state within 7 days. Distribution Calcitriol is approximately 99.9% bound in blood. Calcitriol and other vitamin D metabolites are transported in blood, by an alpha-globulin vitamin D binding protein. There is evidence that maternal calcitriol may enter the fetal circulation. Calcitriol is transferred into human breast milk at low levels (ie, 2.2±0.1 pg/mL). Metabolism In vivo and in vitro studies indicate the presence of two pathways ...
The Wnt antagonist DICKKOPF-1 gene is induced by 1α,25-dihydroxyvitamin D3 associated to the differentiation of human colon...
The Wnt-β-catenin pathway is aberrantly activated in most colon cancers. DICKKOPF-1 (DKK-1) gene encodes an extracellular Wnt inhibitor that blocks the formation of signalling receptor complexes at the plasma membrane. We report that 1α,25-dihydroxyvitamin D3 [1,25(OH)2D3], the most active vitamin D metabolite, increases the level of DKK-1 RNA and protein in human SW480-ADH colon cancer cells. This effect is dose dependent, slow and depends on the presence of a transcription-competent nuclear vitamin D receptor (VDR). Accordingly, 1,25(OH)2D3 activates a 2300 bp fragment of the human DKK-1 gene promoter. Chromatin immunoprecipitation assays revealed that 1,25(OH)2D3 treatment induced a pattern of histone modifications which is compatible with transcriptionally active chromatin. DKK-1 is expressed at high level in colon cancer cell lines with a differentiated phenotype such as Caco-2 or HT-29. Exogenous expression of E-cadherin into SW480-ADH cells results in a strong adhesive phenotype and a ...
The dichotomy in the effects of 1,25 dihydroxyvitamin D<sub>3</sub> and 24,25-dihydroxyvitamin D<sub>3</sub> on bone γ...
TY - JOUR. T1 - The dichotomy in the effects of 1,25 dihydroxyvitamin D3 and 24,25-dihydroxyvitamin D3 on bone γ-carboxyglutamic acid-containing protein in serum and bone in vitamin D-deficient rats. AU - Wientroub, Shlomo. AU - Price, Paul A.. AU - Reddi, A Hari. PY - 1987/5. Y1 - 1987/5. N2 - Vitamin D-deficient, second generation, rachitic rats showed significant decrease in bone Gla protein (BGP) levels in circulation and in the skeleton. 1,25 dehydroxyvitamin D3 (1,25 (OH)2D3) exhibited the most potent influence on serum BGP levels in a dose-dependent manner. At a dose 25 ng/100 g body weight 1,25 (OH)2D3 showed a cumulative effect, i.e., the longer the treatment, the more circulating BGP was detected 24,25 dehydroxyvitamin D3 (24,25(OH)2D3) at the same doses did not show similar effect on the serum BGP levels, regardless of the serum calcium levels. Bone BGP levels assayed at various sites representing endochondral and intramenbranous ossification demonstrated an opposite pattern. ...
Lirias: Immunoregulation by 1,25-dihydroxyvitamin D3: basic concepts
1,25-Dihydroxyvitamin D(3) (1,25(OH)(2)D(3)), the biologically active metabolite of Vitamin D(3), not only regulates bone and calcium metabolism but also exerts other biological activities, including immunomodulation via the nuclear Vitamin D receptor expressed in antigen-presenting cells and activated T cells. This regulation is mediated through interference with nuclear transcription factors such as NF-AT and NF-kappaB or by direct interaction with Vitamin D responsive elements in the promoter regions of cytokine genes. Dendritic cells (DCs) are primary targets for the immunomodulatory activity of 1,25(OH)(2)D(3), as indicated by inhibited DC differentiation and maturation, leading to down-regulated expression of MHC-II, costimulatory molecules and IL-12. Moreover, 1,25(OH)(2)D(3) enhances IL-10 production and promotes DC apoptosis. Together, these effects of 1,25(OH)(2)D(3) inhibit DC-dependent T cell activation. Immunomodulation by 1,25(OH)(2)D(3) and its analogs in vivo has been ...
In the first pilot trial with calcitriol, Walter et al. (5) reported no differences in fasting C-peptide, AUC C-peptide, and peak C-peptide after a mixed meal between treated and placebo groups at 9 and 18 months. A1C and insulin requirement were also similar between the groups. In the aforementioned study, no threshold of C-peptide level at study entry was defined. We designed a trial in which patients were younger at diagnosis, including also children, and should have had basal C-peptide levels at entry ,0.25 nmol/l so that a possible effect of calcitriol on disease progression could have been detected. We have shown that calcitriol does not affect residual β-cell function in such patients, even those of younger age. Similar to the German trial describing a mean C-peptide decrease of ∼40% at 18 months, in our study, decline of C-peptide after 24 months was 44.4% in the calcitriol group and 42.5% in the placebo group. These findings substantially confirm the data from combined studies ...
Cancers | Free Full-Text | Gene Regulatory Scenarios of Primary 1,25-Dihydroxyvitamin D3 Target Genes in a Human Myeloid...
Genome- and transcriptome-wide data has significantly increased the amount of available information about primary 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) target genes in cancer cell models, such as human THP-1 myelomonocytic leukemia cells. In this study, we investigated the genes G0S2, CDKN1A and MYC as master examples of primary vitamin D receptor (VDR) targets being involved in the control of cellular proliferation. The chromosomal domains of G0S2 and CDKN1A are 140-170 kb in size and contain one and three VDR binding sites, respectively. This is rather compact compared to the MYC locus that is 15 times larger and accommodates four VDR binding sites. All eight VDR binding sites were studied by chromatin immunoprecipitation in THP-1 cells. Interestingly, the site closest to the transcription start site of the down-regulated MYC gene showed 1,25(OH)2D3-dependent reduction of VDR binding and is not associated with open chromatin. Four of the other seven VDR binding regions contain a typical DR3-type VDR
WildAlchemist: Vitamin D revealed to be miracle anti-cancer drug with astonishing chemical properties
A new study published this month finds that the hormonally active form of vitamin D, Calcitriol 1,25-dihydroxyvitamin D(3), inhibits the growth of many kinds of cancerous cells, including breast cancer, indicating that vitamin D3 can be useful in treating and even preventing a variety of cancers. Authors of the study said that caner cell growth is inhibited by anticancer actions including cell cycle arrest, promotion of apoptosis and inhibition of invasion, metastasis, and angiogenesis. Vitamin Ds anti-inflammatory properties and interference with estrogen synthesis further explains its anti-tumor properties. Two studies from 2007 used meta-analysis, which combines data from multiple reports, to find that therapeutic doses of vitamin D could prevent up to half of all cases of breast cancer, and two-thirds of all cases of colorectal cancer in the United States. The studies showed a direct correlation between blood levels of vitamin D and cancer. Those with the highest blood levels were found ...
Cell membrane proteomic analysis identifies proteins differentially expressed in osteotropic human breast cancer cells. -...
en] Metastatic breast cancer cells are characterized by their high propensity to colonize the skeleton and form bone metastases, causing major morbidity and mortality. Identifying key proteins involved in the osteotropic phenotype would represent a major step toward the development of both new prognostic markers and new effective therapies. Cell surface proteins differentially expressed in cancer cells are preferred potential targets for antibody-based targeted therapies. In this study, using cell surface biotinylation and a mass spectrometric approach, we have compared the profile of accessible cell surface proteins between the human breast cancer cell line MDA-MB-231 and its highly osteotropic B02 subclone. This strategy allowed the identification of several proteins either up- or downregulated in the osteotropic cell line, and differential protein expressions were validated using antibody-based techniques. Class I HLAs were down-regulated in the bone metastatic variant, whereas ...
calcitriol - Corporate On-Site Therapies
Some scientists believe that a low blood level of Vitamin D (calcifediol) is not necessarily linked to a low level of active vitamin D (calcitriol). On the contrary, for a minority with chronic illness, the body may try to downregulate the production of calcifediol when calcitriol is already in excess, following a disregulation of the VDR. Therefore, routine vitamin D3 supplementation of all patients based on their calcifediol blood test may be counterproductive for a minority of individuals. Their blood levels should be tested for calcitriol rather than calcifediol although this alternative test is not a standardized blood test. More to come in next episode. Resources :.  Ulrike Lehmann, Frank Hirche, Gabriele I. Stangl, Katja Hinz, Sabine Westphal, Jutta Dierkes. Bioavailability of Vitamin D2 and D3 in Healthy Volunteers, a randomised placebo-controlled trial. JCEM jc.2012-4287..  Anne Marie Uwitonze, BDT, MS; Mohammed S. Razzaque, MBBS, PhD (2018) Review : Role of Magnesium in Vitamin D ...
Hypercalciuria due to combined growth hormone and calcitriol therapy in uremia: effects of growth hormone on mineral...
Hypercalciuria due to combined growth hormone and calcitriol therapy in uremia: effects of growth hormone on mineral homeostasis in 75% nephrectomized weanling rats.
CUTANEOUS COMPOSITION COMPRISING VITAMIN D ANALOGUE AND A MIXTURE OF SOLVENT AND SURFACTANTS - Patent application
0006] In the research leading to the present invention, it was surprisingly found that certain three-component surfactant-solvent mixtures of a type which self-emulsifies in the presence of an excess of water to form microemulsions are suitable for inclusion in topical compositions for application on skin. The mixtures also exhibit a good solubilization capacity in dissolving sparingly water-soluble active ingredients such as vitamin D derivatives and analogues. The compositions are easily spreadable, and therefore likely to improve patient compliance, and exhibit an adequate physical and chemical stability. Compositions according to the invention comprising a vitamin D derivative or analogue have surprisingly been found to lead to a very high activation of the target gene cathelicidin in the biological assay described in Example 7 below, suggesting that the active ingredient is internalized by the keratinocytes on which the compositions are applied and activates the vitamin D receptor to a ...
Protein which interacts with any form of the fat-soluble vitamin D or protein whose transcription is regulated by the biologically active form of vitamin D, i.e. 1,25-dihydroxy vitamin D3 (1,25 dihydroxycholecalciferol) also termed calcitriol. Active calcitriol is derived from ergosterol (produced in plants) and 7-dehydrocholesterol (produced in the skin). Ergocalciferol (vitamin D2) and cholecalciferol (vitamin D3) are formed by UV irradiation of ergosterol and 7-dehydrocholesterol, respectively, and processed by the same enzymatic pathway in the body to D2-calcitriol and D3-calcitriol. Deficiency in vitamin D leads to the disease rickets, in children, and osteomalacia, in adults ...
Indian Patents. 247527:GEMINI VITAMIN D3 COMPOUND
and Thomasset M. (1990) Endocrinology 127:580-587). The bone-oriented assays include: 1) assessment of bone resorption as determined via the release of Ca2+ from bone in vivo (in animals fed a zero Ca2+diet) (Hibberd K.A. and Norman A.W. (1969) Biochem. Pharmacol 18:2347-2355; Hurwitz S. etal (1967)7. Nutr. 91:319-323), or from bone explants in vitro (Bouillon R. et al (1992) J. Biol Chem. 267:3044-3051), 2) measurement of serum osteocalcin levels [osteocalcin is an osteoblast-specific protein that after its synthesis is largely incorporated into the bone matrix, but partially released into the circulation (or tissue culture medium) and thus represents a good market of bone formation or turnover] (Bouillon R. et al (1992) Clin. Chem. 38:2055-2060), or 3) bone ash content (Norman A.W. and Wong R.G. (1972) J. Nutr. 102:1709-1718). Only one kidney-oriented assay has been employed. In this assay, urinary Ca2+ excretion is determined (Hartenbower D.L. et al (1977) Walter de Gruyter, Berlin pp ...
Vitamin D receptor expression in peripheral blood mononuclear cells is inversely associated with disease activity and...
PBMC VDR expression is inversely associated with disease activity and inflammation in SLE patients, and VDR downregulation is likely driven by inflammation.
BeatingCancerCenter - The Di Bella Method - Anti-oestrogen resistant human breast cancer cell lines are more sensitive towards...
Anti-oestrogen resistant human breast cancer cell lines are more sensitive towards treatment with the vitamin D analogue EB1089 than parent MCF-7 cells.
Publications | College of Veterinary Medicine
Hostutler RA, DiBartola SP, Chew DJ, Nagode LA, Schenck PA, Rajala-Schultz PJ, Drost WT: Comparison of the effects of daily and intermittent-dose calcitriol on serum parathyroid hormone and ionized calcium concentrations in normal cats and cats with chronic renal failure. J Vet Intern Med 20(6): 1307-1313, 2006 ...
Calcifediol-loaded liposomes for local treatment of pulmonary bacterial infections. | LJMU Research Online
The influence of vitamin D3 and its metabolites calcifediol (25(OH)D) and calcitriol on immune regulation and inflammation is well described, and raises the question of potential benefit against bacterial infections. In the current study, 25(OH)D was encapsulated in liposomes to enable aerosolisation, and tested for the ability to prevent pulmonary infection by Pseudomonas aeruginosa. Prepared 25(OH)D-loaded liposomes were nanosized and monodisperse, with a negative surface charge and a 25(OH)D entrapment efficiency of approximately 23%. Jet nebulisation of liposomes was seen to yield an aerosol suitable for tracheo-bronchial deposition. Interestingly, 25(OH)D in either liposomes or ethanolic solution had no effect on the release of the proinflammatory cytokine KC from Pseudomonas-infected murine epithelial cells (LA-4); treatment of infected, human bronchial 16-HBE cells with 25(OH)D liposomes however resulted in a significant reduction in bacterial survival. Together with the importance of ...
Nutrients | Free Full-Text | Molecular Link between Vitamin D and Cancer Prevention | HTML
The metabolite of vitamin D, 1α,25-dihydroxyvitamin D3 (also known as calcitriol), is a biologically active molecule required to maintain the physiological functions of several target tissues in the human body from conception to adulthood. Its molecular mode of action ranges from immediate nongenomic responses to longer term mechanisms that exert persistent genomic effects. The genomic mechanisms of vitamin D action rely on cross talk between 1α,25-dihydroxyvitamin D3 signaling pathways and that of other growth factors or hormones that collectively regulate cell proliferation, differentiation and cell survival. In vitro and in vivo studies demonstrate a role for vitamin D (calcitriol) in modulating cellular growth and development. Vitamin D (calcitriol) acts as an antiproliferative agent in many tissues and significantly slows malignant cellular growth. Moreover, epidemiological studies have suggested that ultraviolet-B exposure can help reduce cancer risk and prevalence, indicating a potential role
Oral Paricalcitol May Have Similar Efficacy to Oral Calcitriol - Renal and Urology News
OP appears to have similar efficacy and safety compared with oral calcitriol (OC) in dialysis patients with secondary hyperparathyroidism (SHPT).
Maturation state determines the response of osteogenic cells to surface roughness and 1,25-dihydroxyvitamin D<sub>3<...
TY - JOUR. T1 - Maturation state determines the response of osteogenic cells to surface roughness and 1,25-dihydroxyvitamin D3. AU - Lohmann, C. H.. AU - Bonewald, L. F.. AU - Sisk, M. A.. AU - Sylvia, V. L.. AU - Cochran, D. L.. AU - Dean, D. D.. AU - Boyan, Barbara D.. AU - Schwartz, Z.. PY - 2000/1/1. Y1 - 2000/1/1. N2 - In this study we assessed whether osteogenic cells respond in a differential manner to changes in surface roughness depending on their maturation state. Previous studies using MG63 osteoblast-like cells, hypothesized to be at a relatively immature maturation state, showed that proliferation was inhibited and differentiation (osteocalcin production) was stimulated by culture on titanium (Ti) surfaces of increasing roughness. This effect was further enhanced by 1,25-dihydroxyvitamin D3 [1,25(OH)2D3]. In the present study, we examined the response of three additional cell lines at three different maturation states: fetal rat calvarial (FRC) cells (a mixture of multipotent ...
Dihydroxyvitamin D3, 1 α, 25-[26,27-3H]-, 5µCi (185kBq) | PerkinElmer
5 µCi quantities of 1 a, 25-[26, 27-3H]-Dihydroxyvitamin D3, are available for your research. Application of [3H] Dihydroxyvitamin D3 can be found in: appearance of the rat testicular receptor during development in steroid biochemistry, in determination as a major intermediate in 25-hydroxyvitamin D3-26,23-lactone formation, receptors in the choroid plexus and ependyma in cellular neuroscience, etc.. ...
Nuclear Receptor/Transcription Factor | DC Chemicals
Maxacalcitol 22-Oxacalcitriol is a Vitamin D3 analog which is Non-calcemic as well as a VDR ligand. 22-Oxacalcitriol has been shown to decrease parathyroid hormone (PTH) mRNA expression in vitro. Additionally has been noted to exhibit similar effects to calcitriol in. ...
Hypercalcemia, Hodgkins Disease, and Calcitriol | Annals of Internal Medicine | American College of Physicians
To the editor: We read with interest the recent report by Breslau and associates (1). We have recently studied the case of a patient with Hodgkins disease with hypercalcemia and increased calcitriol levels.. A 51-year-old white man was admitted to St. Josephs Hospital and Medical Center with polyuria, polydyspia, and constipation. The only abnormal findings on physical examination were hard 1- to 2-cm left inguinal lymphadenopathy and a spleen tip palpable on deep inspiration. Laboratory data included serum calcium, 11.7 mg/dL; inorganic phosphorus, 2.1 mg/dL; creatinine, 2.9 mg/dL; albumin, 4.3 mg/dL; magnesium, 2.1 mg/dL; and alkaline phosphatase, 0.52 IU/L. Thyroid ...
Vitamin D-sensitive calcium signaling in depression (Homo sapiens) - WikiPathways
Depression has been linked to (lack of) sunlight exposure and raised intracellular calcium levels. In this pathway, the role of the vitamin D pathway in calcium signaling in depression is shown. Active 1,25-dihydroxy-vitamin D3 is formed from 7-dehydrocholesterol by multiple conversion steps. It associates with RXR and VDR in the nucleus, which stimulates transcription of VDR target genes, resulting in lower intracellular calcium levels. Less sunlight exposure results in lower 1,25-dihydroxyvitamin D3 levels and therefore higher calcium levels ...
Can you overdose on calcitriol?
Administration of Rocaltrol (calcitriol) to patients in excess of their daily requirements can cause hypercalcemia, hypercalciuria, and hyperphosphatemia. Since calcitriol is a derivative of vitamin D, the signs and symptoms of overdose are the same as for an overdose of vitamin D (see ADVERSE REACTIONS).
BeatingCancerCenter - The Di Bella Method - Role of vitamin D receptor in the antiproliferative effects of calcitriol in tumor...
Role of vitamin D receptor in the antiproliferative effects of calcitriol in tumor-derived endothelial cells and tumor angiogenesis in vivo.
Private MD Health News - Vitamin D Deficiency-Diagnosis and Treatment News
It may be more important than ever for older people to get enough vitamin D in their systems, either from the sun or through nutritional supplements. According to a new study, their lives may depend on it.... Full Story ...
1.25 dihydroxyvitamin D3 receptor exist of osteoclast precursors<...
TY - JOUR. T1 - 1.25 dihydroxyvitamin D3 receptor exist of osteoclast precursors. AU - Kamioka, Hiroshi. PY - 1991. Y1 - 1991. M3 - Article. VL - 28. SP - 185. EP - 189. JO - Dentitry in Japan. JF - Dentitry in Japan. ER - ...
Calcitriol Inhibits the Th1 and Promotes the Th2 Profile in Mice with TNBS Colitis. Th1 lymphocyte differentiation is known to be based on a sequence of cell-intrinsic and exogenous, DC-derived factors, including augmentation of the transcription factor T-bet following activation by DC-derived IL-12. The observed reduction of the Th1 mediators, especially after treatment with the combination of dexamethasone and calcitriol, was further confirmed by immunoblot analysis of the T-bet. The combined administration of calcitriol and dexamethasone led to a significant reduction of T-bet protein expression compared with dexamethasone monotherapy (P , 0.001 versus dexamethasone, Fig. 3, A and B). As a next step to assess a possible role of calcitriol and dexamethasone in promoting the Th2 subset, we analyzed IL-4 production as well as the relevant Th2 lineage commitment factor GATA3. Calcitriol significantly up-regulated IL-4, whereas dexamethasone alone did not cause any significant change in IL-4 ...
1,25-Dihydroxyvitamin D3 prevented allergic asthma in a rat model...: Ingenta Connect
The active form of 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] regulates calcium homeostasis, immunity, and other physiological processes while its effect in T-helper lymphocyte type 2 models is not very clear. The prevention effect of 1,25(OH)2D3 for allergic asthma in a rat asthma model was investigated. Healthy Wistar rats were randomly divided into four groups: control group, asthma group, drug prevention group, and treatment group. Asthma was induced in rats by sensitization and challenges with ovalbumin (OVA). The drug prevention group and treatment group were given 1,25(OH)2D3 or vitamin D3 on different schedules. The effects of 1,25(OH)2D3 on the development of asthma were analyzed. The airway hyperresponsiveness, the inflammatory cell infiltration in bronchoalveolar lavage (BAL) fluid, and histological changes of lung cells were examined. Nitric oxide production and the expression and activity of induced nitric oxide synthase (iNOS) in the lungs were examined also. Our study showed that ...
1α,25-dihydroxyvitamin D3 promotes osteogenic activity and downregulates proinflammatory cytokine expression in human...
The aim of this study was to assess the impact of 1α,25-dihydroxyvitamin D3 (vitamin D3) on osteogenic and inflammatory properties of human periodontal ligament (PDL) cells and investigate underlying mechanisms ...
clinical Significance of the New Vitamin B 12 and Intrinsic Factor Research]. - Semantic Scholar
Semantic Scholar extracted view of [clinical Significance of the New Vitamin B 12 and Intrinsic Factor Research]. by Konrad-Felix Krentz
0.25 mcg of calcitriol is eequivalent to how many i.u. of cholecalciferol?
1 Answer - Posted in: calcitriol, cholecalciferol - Answer: No - the doses are not the same. One IU of Vitamin D (Cholecalciferol) ...
Hall of Record: May 2008
Hayes CE, Cantorna MT, DeLuca HF. Department of Biochemistry, University of Wisconsin-Madison 53706, USA.. Recently, it has been clearly demonstrated that exogenous 1,25-dihydroxyvitamin D3, the hormonal form of vitamin D3, can completely prevent experimental autoimmune encephalomyelitis (EAE), a widely accepted mouse model of human multiple sclerosis (MS). This finding has focused attention on the possible relationship of this disease to vitamin D. Although genetic traits certainly contribute to MS susceptibility, an environmental factor is also clearly involved. It is our hypothesis that one crucial environmental factor is the degree of sunlight exposure catalyzing the production of vitamin D3 in skin, and, further, that the hormonal form of vitamin D3 is a selective immune system regulator inhibiting this autoimmune disease. Thus, under low-sunlight conditions, insufficient vitamin D3 is produced, limiting production of 1,25-dihydroxyvitamin D3, providing a risk for MS. Although the evidence ...
Patent US4973584 - Novel 1α-hydroxyvitamin D2 epimer and derivatives - Google Patents
The invention provides a new vitamin D2 compound, 1α-hydroxy-24-epi-vitamin D2 and certain hydroxy-protected derivatives thereof. The new compound exhibits a distinctive activity pattern comprising high potency in stimulating intestinal calcium transport and little or no activity in inducing bone calcium mobilization or the differentiation of undifferentiated cells in culture, thereby evincing utility in the treatment of diseases characterized by loss of bone mass.
Thus calcitriol also stimulates the intestinal absorption of phosphate. The observation that calcitriol stimulates the release ... PTH also stimulates the production of calcitriol (see below). Many of the effects of calcitriol are mediated by its interaction ... Calcitriol was identified as the active form of vitamin D in 1971 and the drug was approved for medical use in the United ... Calcitriol is produced in the cells of the proximal tubule of the nephron in the kidneys by the action of 25-hydroxyvitamin D3 ...
Carrillo-López N, Fernández-Martín JL, Cannata-Andía JB (2009-04-01). "[The role of calcium, calcitriol and their receptors in ... calcitriol), which is released into the circulation. This latter form of vitamin D is the active hormone which stimulates ... Calcitriol Increase in serum phosphate. Fibroblast growth factor-23 (FGF23) is produced in osteoblasts (from bone) in response ...
Rocaltrol (calcitriol), for osteoporosis and hypocalcaemia. Rocephin (ceftriaxone), a broad-spectrum cephalosporin antibiotic. ...
... (sitocalciferol) is a form of vitamin D. Analogs of calcitriol, a form of vitamin D3, have been proposed for use as ... The motive to study 1α-hydroxyvitamin D5 as a potential pharmaceutical drug stemmed from the tendency of calcitriol, a natural ... Thus, the therapeutic effects of 1α-Hydroxyvitamin D5 as a potential antitumor agent without the side effects of calcitriol ... Beer, Tomasz M.; Myrthue, Anne (March 2004). "Calcitriol in cancer treatment: from the lab to the clinic". Molecular Cancer ...
... (INN) is an analog of calcitriol. It has a higher potency both in vivo and in vitro systems, and longer duration ...
Mater Misericordiae University Hospital
Caniggia A, Nuti R, Lore F, Martini G, Turchetti V, Righi G (April 1990). "Long-term treatment with calcitriol in ...
Caniggia A, Nuti R, Lore F, Martini G, Turchetti V, Righi G (April 1990). "Long-term treatment with calcitriol in ...
... a heterodimer transcriptional coactivator that is dependent on calcitriol. Calcitriol is a form of vitamin D that is partly ... Calcitriol is also a molecule relied on by the lungs for proper function. Finally, TMEM211 displayed an extreme pattern of ... Calcitriol is also passed from nursing mothers in breastmilk. Furthermore, oral administration of estrogen has been shown to ... It is also of interest that calcitriol treatment has been shown to increase the expression of LHFPL RNA. The 5'UTR of TMEM211 ...
Fibroblast growth factor 23
... inhibition of production of calcitriol, stimulation of breakdown of calcitriol, and inhibition of production/secretion of ... FGF23 is secreted by osteocytes in response to increased calcitriol. FGF23 acts on the kidneys, where it decreases the ...
Calcitriol (1,25-dihydroxycholecalciferol) is the active form of vitamin D3. It has numerous functions involved in blood ... Recent research indicates that calcitriol leads to a reduction in osteoclast formation, and bone resorption. It follows that an ... the precursor to calcitriol. Calcitonin is a hormone secreted by the thyroid in humans. Calcitonin decreases osteoclast ...
... may also participate in Vitamin D (specifically, calcitriol) signaling as a membrane-bound receptor. It has been ... November 2016). "Analysis of the interaction of calcitriol with the disulfide isomerase ERp57". Scientific Reports. 6: 37957. ...
Calcitriol (Rocaltrol) and cinacalcet (a calcimimetic) are used as pharmacologic treatments. Age and gender have an effect on ...
Oral phosphate and calcitriol may be given for treatment of hypophosphatemia. For growth hormone excess, treatment with ...
Membrane steroid receptor
November 2016). "Analysis of the interaction of calcitriol with the disulfide isomerase ERp57". Scientific Reports. 6: 37957. ... PDIA3 is a membrane receptor for the secosteroid calcitriol, the activated form of Vitamin D. Semicolons roughly denote ...
Calcitriol (vitamin D) significantly inhibits the expression of the COX-2 gene. Caution should be exercised in combining low ...
Synthesis of osteopontin is stimulated by calcitriol (1,25-dihydroxy-vitamin D3). Regulation of the osteopontin gene expression ... Hypocalcemia and hypophosphatemia (instances that stimulate kidney proximal tubule cells to produce calcitriol (1α,25- ...
Calcitriol, the activated form of vitamin D, promotes intestinal absorption of calcium and the renal reabsorption of phosphate ... For example, they convert a precursor of vitamin D to its active form, calcitriol; and synthesize the hormones erythropoietin ... The kidneys secrete a variety of hormones, including erythropoietin, calcitriol, and renin. Erythropoietin is released in ...
Calcitriol, the activated form of vitamin D, promotes intestinal absorption of calcium and the renal reabsorption of phosphate ... The kidneys secrete a variety of hormones, including erythropoietin, calcitriol, and renin. Erythropoietin is released in ...
... such as calcitriol, doxercalciferol, paricalcitol; and phosphate binders, which are either calcium-based and non-calcium based ...
... calcitriol, performs its function through interactions with the calcitriol receptor. This nuclear hormone receptor is ... This greater affinity is 2.7-fold that of the active vitamin D form of calcitriol. Eldecalcitol is readily absorbed into the ... The chemistry of eldecalcitol allows for its binding 2.7-fold more potently than calcitriol. In addition, some vitamin D ... The eldecalcitol analog of calcitriol, contains a hydroxypropyl group in the lower cyclohexane ring. The synthesis of ...
Naive T cell
Hence the activation of naive T cells is crucially dependent on adequate calcitriol levels. In summary, activation of T cells ... However, activated TCR signaling through p38 upregulates VDR expression and calcitriol activated VDR, in turn, upregulates PLC- ... the expression of PLC-γ1 is dependent on VDR activated by calcitriol. Naive T cells have very low expression of VDR and PLC-γ1 ...
Biochemically in blood, XLH is recognized by hypophosphatemia and an inappropriately low level of calcitriol (1,25-(OH)2 ... It is also treated with medications including human growth hormone, calcitriol, and phosphate. International XLH Alliance - an ... while calcitriol levels are low or within the lower reference range. Most importantly, urinary loss of phosphate is above the ... calcitriol; in the event of severe bowing, an osteotomy may be performed to correct the leg shape. The monoclonal antibody ...
Elevated Calcitriol is suggestive of lymphoma, sarcoidosis, granulomatous disorders, and excessive calcitriol intake. Elevated ... These plants contain calcitriol or similar substances that cause rises in calcium ion levels. Hypercalcemia is most common in ... see calcitriol under Vitamin D) levels (e.g. sarcoidosis and other granulomatous diseases such as tuberculosis, berylliosis, ...
It stimulates the manufacture and release, by the kidneys, of calcitriol into the blood. This steroid hormone acts on the ...
The action of calcitriol is mediated by the vitamin D receptor, a nuclear receptor which regulates the synthesis of hundreds of ... It is converted in the liver to calcifediol (25-hydroxyvitamin D) which is then converted in the kidney to calcitriol (1,25- ... Hydroxylation in the kidneys of calcifediol to calcitriol by 1-alpha-hydroxylase is tightly regulated: it is stimulated by ... 25-Hydroxyvitamin D3 1-alpha-Hydroxylase, a kidney enzyme that converts calcifediol to calcitriol. Coulston AM, Boushey C, ...
It has been suggested, based on animal research, that calcitriol, the active metabolite of vitamin D, can provide significant ... Cass WA, Smith MP, Peters LE (2006). "Calcitriol protects against the dopamine- and serotonin-depleting effects of neurotoxic ...
Expression could be induced by treating these animals with vitamin D metabolites such as calcitriol. They were found to exist ... Expression of S100G, like that of calbindin 1, is stimulated by the active vitamin D metabolite, calcitriol although the ...
Atkins KB, Troen BR (July 1995). "Regulation of cathepsin D gene expression in HL-60 cells by retinoic acid and calcitriol". ...
Osteitis fibrosa cystica
ESRD occurs when the kidneys fail to produce calcitriol, a form of vitamin D, which assists in the absorption of calcium into ... When calcitriol levels decrease, parathyroid hormone levels increase, halting the storage of calcium, and instead triggering ... Medical management of OFC consists of vitamin D treatment, generally alfacalcidol or calcitriol, delivered intravenously. ...
Chronic kidney disease-mineral and bone disorder
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- The recommended initial dosage of calcitriol is 0.25 mcg/day in adults and pediatric patients 3 years of age and older . (drk-schluechtern.de)
- The recommended dose of Calcitriol capsule is 0.25 mcg twice daily. (kjhbazar.com)
- The initial daily dose is 0.25 mcg of Calcitriol capsule. (kjhbazar.com)
- The recommended initial dosage of Calcitriol capsule is 0.25 mcg/day which given in the morning. (kjhbazar.com)
- Al respecto de los productos farmacéuticos solicitados se evidencia que en el Petitorio Nacional Único de Medicamentos - PNUME vigente sólo se ha incluido al Calcitriol de 1mcg/mL y el Calcitriol de 0.25 mcg, no encontrándose Solución de Joulie (fosfato disódico+ácido fosfárico), Litiasin (citrat. (bvsalud.org)
- Calcitriol is in a class of medications called vitamin D analogs. (medlineplus.gov)
- Calcitriol is also sometimes used to treat rickets (softening and weakening of bones in children caused by lack of vitamin D), osteomalacia (softening and weakening of bones in adults caused by lack of vitamin D), and familial hypophosphatemia (rickets or osteomalacia caused by decreased ability to break down vitamin D in the body). (medlineplus.gov)
- At the end of that period, they were switched to calcitriol ointment (3 μg/g), an active form of vitamin D, self-applied twice a day for up to 8 weeks. (medscape.com)
- Calcitriol is an "activated" vitamin D that is used as an adjunctive treatment for chronic renal disease in cats and dogs. (thrivingpets.com)
- Conversion of vitamin D3 from its largely inactive form (calciol, also called cholecalciferol) into a hormonally active form (calcitriol). (planteome.org)
- Calcitriol is a form of vitamin D that is active in the body. (pharmachoice.com)
- Calcitriol may also be used to treat vitamin D-resistant rickets, a bone disease caused by too little vitamin D. (pharmachoice.com)
- Calcitriol medication is a Vitamin D3 Analog, which is a hydroxy calciol in which the pro-S hydrogen of calcitriol is replaced by a hydroxy group. (thetopmedstore.com)
- Calcitriol is a man-made Vitamin D that helps to control parathyroid hormone and the levels of certain minerals like calcium, phosphorus. (thetopmedstore.com)
- Calcitriol is a topical vitamin D analog similar to calcipotriene but seems to be less irritating in sensitive areas of skin. (medscape.com)
- Symptoms of calcitriol toxicity mirrors the early and late signs and symptoms of vitamin D intoxication associated with hypercalcemia 10 . (drk-schluechtern.de)
- Calcitriol is a form of vitamin D3. (drk-schluechtern.de)
- Is calcitriol better than vitamin D? (drk-schluechtern.de)
- Can you take calcitriol and vitamin D together? (drk-schluechtern.de)
- Calcitriol is very similar to other forms of vitamin D. Do not use medications containing other forms of vitamin D while using calcitriol . (drk-schluechtern.de)
- Is calcitriol the same as vitamin D3? (drk-schluechtern.de)
- Calcitriol, which is actually the most active form of vitamin D [100-times higher than 25(OH)D3] has a very short half-life, of about a few hours. (drk-schluechtern.de)
- How many units of vitamin D are in calcitriol? (drk-schluechtern.de)
- To compare the effects of cholecalciferol (800 IU/d) and calcitriol ( 0.25 μg/d ) on calcium metabolism and bone turnover in Chinese postmenopausal women with vitamin D insufficiency. (drk-schluechtern.de)
- Rocaltrol (Calcitriol) is a form of vitamin D, necessary for normal bone development. (boldbare.com)
- Calcitriol is vitamin D3. (boldbare.com)
- You should not use this medication if you have high levels of calcium or vitamin D in your blood, or if you have ever had an allergic reaction to calcitriol or other forms of vitamin D. Drink plenty of fluids unless your doctor has told you to restrict your fluid intake. (boldbare.com)
- Vitamin D's active form is calcitriol. (adenhealthcare.com)
- hydroxylase enzyme, preventing the conversion of vitamin D into the active form of calcitriol. (paediatricaindonesiana.org)
- Decreased vitamin D levels may occur at an early stage of the disease, so it is important to evaluate calcitriol levels in children with early stage CKD. (paediatricaindonesiana.org)
- Calcitriol 's improvement of control barrier function was not additive to barrier improvement induced by retinoic acid ( Vitamin A ). Calcitriol improvement and protection of airway barrier function could in part explain Vitamin D 's reported clinical efficacy in COVID-19 and other airway diseases . (bvsalud.org)
- To understand vitamin D pharmocology one needs to be familiar with the different forms of vitamin D, namely cholecalciferol, calcidiol, and calcitriol. (vitamindcouncil.org)
- It is sometimes referred to as the active form of vitamin D. Calcitriol levels should never be used to determine if you are deficient in vitamin D. (vitamindcouncil.org)
- Since calcitriol is one of the most important active metabolites of vitamin D3, pharmacological doses of vitamin D and its derivatives should be withheld during treatment with calcitriol to avoid possible additive effects and hypercalcemia. (mims.com)
- Offering you a complete choice of products which include calcium carbonate calcium calcitriol vitamin k 2 7. (gemedlifesciences.com)
- Standard protocol for treatment of familial hypophosphatemic rickets includes the use of 1,25-dihydroxy-vitamin D (calcitriol). (medscape.com)
- The use of calcitriol in place of standard vitamin D obviates near-toxic dosage of the latter, avoids fat storage of parent vitamin D, and diminishes the danger of hypercalcemia. (medscape.com)
- Calcitriol is one of the most important active metabolites of vitamin D3. (kjhbazar.com)
- Vitamin D becomes active in the body after a two-stage synthesising process that converts vitamin D3 - predominantly produced by sunlight on skin - into calcitriol, the most potent steroid hormone in the body. (antiaging-nutrition.com)
- Because vitamin D's active hormone, calcitriol, is particularly beneficial to bone health due to its role in aiding calcium and phosphorous absorption, a deficiency can lead to thin, brittle, misshapen bones, or the bone disease, osteomalacia (known as rickets in children). (antiaging-nutrition.com)
- Once vitamin D is absorbed from food or produced in the skin, it travels to the liver and kidneys, transforming it into its active form, calcitriol. (ziggiesocial.com)
- This means your body needs the right amount of vitamin D3 (also known as calcitriol) before it can convert it into a hormone produced by the kidney. (happyhealthyhippieco.com)
- The concurrent use of calcitriol (CAL) pulse therapy to reduce parathyroid hormone (PTH) secretion and of calcium (Ca) salts as the most appropriate phosphate binders was evaluated for over 1 year in a group of 14 patients with good divalent ion control on CaCO3 therapy but with increasing levels of serum intact PTH. (nih.gov)
- Mineral homeostasis is regulated by a complex network involving endocrine actions by calcitriol, parathyroid hormone (PTH), and FGF23 on several organs including kidney, intestine, and bone. (uzh.ch)
- Take calcitriol exactly as directed. (medlineplus.gov)
- Your doctor will probably tell you not to take calcitriol. (medlineplus.gov)
- Drug interactions are reported only by a few people who take Calcitriol and Tropicamide together. (ehealthme.com)
- The phase IV clinical study analyzes what interactions people who take Calcitriol and Tropicamide have. (ehealthme.com)
- 2 people who take Calcitriol and Tropicamide together, and have interactions are studied. (ehealthme.com)
- Do you take Calcitriol and Tropicamide? (ehealthme.com)
- To make sure you can safely take calcitriol, tell your doctor about all of your medical conditions. (boldbare.com)
- Calcitriol comes as a capsule and a solution (liquid) to take by mouth. (medlineplus.gov)
- Each orange, opaque, oval, soft gelatin capsule with "O25" printed in black contains 0.25 µg of calcitriol. (pharmachoice.com)
- Each orangeish-to-red, opaque, oval, soft gelatin capsule with "O50" printed in black contains 0.50 µg of calcitriol. (pharmachoice.com)
- The optimal daily dose of Calcitriol capsule must be carefully determined for each patient on the basis of serum calcium level. (kjhbazar.com)
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- 1.0cm, and hypercalcemia) in dialysis patients may be resistant to conventional calcitriol- pulse therapy. (yonsei.ac.kr)
- Calcitriol dosage must be determined with care in patients undergoing treatment with digitalis, as hypercalcemia in such patients may precipitate cardiac arrhythmias. (mims.com)
- Calcitriol is also contraindicated in all diseases associated with hypercalcemia. (kjhbazar.com)
Side effects of calcitriol1
- If you get too much calcium from foods, you may experience serious side effects of calcitriol, and if you do not get enough calcium from foods, calcitriol will not control your condition. (medlineplus.gov)
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Elevated calcitriol levels1
- Ultimately elevated calcitriol levels increase calciuria and kidney stones . (drk-schluechtern.de)
- Calcitriol is used to treat and prevent low levels of calcium and bone disease in patients whose kidneys or parathyroid glands (glands in the neck that release natural substances to control the amount of calcium in the blood) are not working normally. (medlineplus.gov)
- Calcitriol is used to help increase the amount of calcium in the blood and help with proper bone formation for people with chronic kidney failure that are undergoing dialysis. (pharmachoice.com)
- Calcium in the given medicine Calcitriol plays an important role in maintaining bone health, and low levels of calcium. (thetopmedstore.com)
- Calcitriol is used to treat hyperparathyroidism (overactive parathyroid glands) and metabolic bone disease in people who have chronic kidney failure and are not receiving dialysis . (drk-schluechtern.de)
- Calcitriol is used to treat and prevent low calcium levels and bone damage in people whose kidneys or parathyroid glands are malfunctioning. (adenhealthcare.com)
- Other treatment options include calcitriol, GH, phosphates, and anticalciurics to promote healthy bone growth and diminish mineral loss associated with hypophosphatemic rickets. (medscape.com)
- Calcitriol promotes intestinal absorption of calcium and regulates bone mineralization. (kjhbazar.com)
- D3 Pro 2 and D3 5000 provide an alternative way for the body to produce calcitriol and support bone health, while reducing the risk of numerous diseases and deficiency symptoms. (antiaging-nutrition.com)
- Calcitriol then binds to receptors on cells all over the body, including bone cells, intestine cells, and immune cells. (ziggiesocial.com)
- By binding to these receptors, calcitriol helps to regulate a wide range of processes, including calcium absorption, bone growth, and immune function. (ziggiesocial.com)
- Treatment with intermittent calcitriol and calcium reduces bone loss after renal transplantation. (cdc.gov)
Tell your doctor and pharmacist1
- tell your doctor and pharmacist if you are allergic to calcitriol, any other medications, or any of the ingredients in calcitriol ointment. (epnet.com)
- Calcitriol is a prescription medication commonly used in the treatment of conditions caused by high or low parathyroid levels. (entirelypetspharmacy.com)
- If your pet has been diagnosed with chronic kidney disease, parathyroid disorder, or an associated disease, your veterinarian may prescribe a medication such as calcitriol. (entirelypetspharmacy.com)
- However, some of your cholecalciferol will be turned into calcitriol, a very potent steroid with anti-cancer properties. (vitamindcouncil.org)
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- We three repeatedly injected calcitriol of dose(μg) equal to 3-D nodule volume(cm(3)) under U.S.(Acuson Computa Sono, California, USA, 7MHz probe) for 1 week and concurrently began calcitriol-pulse therapy(0.75-1.0μg/day, t.i.w.) after 3rd injection. (yonsei.ac.kr)
- The recommended intravenous initial dose of Calcitriol injection, depending on the severity of the hypocalcemia and/or secondary hyperparathyroidism, is 1 mcg (0.02 mcg/kg) to 2 mcg administered three times weekly, approximately every other day. (kjhbazar.com)
- Your doctor will probably start you on a low dose of calcitriol and may gradually increase your dose depending on your body's response to calcitriol. (medlineplus.gov)
- The recommended starting dose of calcitriol for adults is 0.25 µg daily. (pharmachoice.com)
- Do not stop taking Calcitriol-AFT or change the dose without first checking with your doctor. (drk-schluechtern.de)
- For pediatric patients less than 3 years of age, the recommended initial dosage of calcitriol is 10 to 15 ng/kg/day. (drk-schluechtern.de)
- Since calcitriol also has an effect on phosphate transport in the intestine, kidneys and bones, the dosage of phosphate binding agents must be adjusted in accordance with the serum phosphate concentration (normal values: 2.5 mg/100 mL or 0.6-1.6 mmol/L). (mims.com)
- 120 µmol/l, the dosage of Calcitriol should be substantially reduced or treatment stopped. (kjhbazar.com)
- Conversion requires 25-hydroxylation of calciol in the liver to form calcidiol, and subsequent 1,alpha-hydroxylation of calcidiol in the kidney to form calcitriol. (planteome.org)
- calcidiol and calcitriol. (vitamindcouncil.org)
- the kidney's inability to convert calcidiol to calcitriol. (antiaging-nutrition.com)
- Calcitriol pulse therapy for severe hyperparathyroidism or calcium salts as phosphate binders in renal dialysis patients? (nih.gov)
- If you do not have kidney disease, you should drink plenty of fluids while taking calcitriol. (medlineplus.gov)
- While calcitriol was first thought to be generated solely in the kidney, it is now recognized in many extrarenal tissues (10-12). (drk-schluechtern.de)
- Can calcitriol cause kidney stones? (drk-schluechtern.de)
- abametapir will increase the level or effect of calcitriol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. (medscape.com)
- apalutamide will decrease the level or effect of calcitriol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. (medscape.com)
- clarithromycin will increase the level or effect of calcitriol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. (medscape.com)
- enzalutamide will decrease the level or effect of calcitriol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. (medscape.com)
- Cholestyramine can reduce intestinal absorption of fat-soluble vitamins and therefore may impair intestinal absorption of calcitriol. (mims.com)
- BARRO-CT is the fusion of various compositions of Calcium Citrate, Elemental Calcium And Calcitriol tablets which is a combo medicine intended to prevent or treat low blood calcium levels in patients who do not consume enough calcium from their daily diet. (adenhealthcare.com)
- Calcitriol increases calcium levels by promoting calcium absorption in the intestines and retention in kidneys. (medscape.com)
- Mothers may breast feed while taking Calcitriol but serum calcium levels of the mother and infant should be monitored. (kjhbazar.com)
Increases blood levels of calcium1
- Calcitriol increases blood levels of calcium by increasing the absorption of calcium in the kidneys , increasing the absorption of calcium and phosphorus from the intestine, and increasing the release of calcium and phosphorus from the bones. (drk-schluechtern.de)
- Magnesium-containing drugs (eg, antacids) may cause hypermagnesemia and should therefore not be taken during therapy with calcitriol by patients on chronic renal dialysis. (mims.com)
- Obat yang mengandung magnesium seperti antasida tidak boleh diberikan secara bersama Calcitriol pada dialysis ginjal kronik karena dapat menyebabkan hypermagnesium. (pt-ana.com)
- These combination therapy could significantly decrease i-PTH level and gland volume in patients with resistant secondary hyperparathyroidism on conventional calcitriol therapy and the response were main-tained for one year after start of these therapy. (yonsei.ac.kr)
- In conclusion, direct calcitriol injections into the parathyroid nodules and pulse combination therapy could be useful in secondary resistant hyperparathyroidism patients with conventional calcitriol therapy especially in those with i-PTH of less than 1,200pg/ml or gland volume of less than 1.5cm. (yonsei.ac.kr)
- Over time, the parathyroid glands become hyperplastic and less susceptible to treatment with calcium and calcitriol, producing a continuous secret ion of PTH and result ing secondar y hyperparathyroidism 3 . (bvsalud.org)
- Is calcitriol good for your kidneys? (drk-schluechtern.de)
- March 17, 2009 (San Francisco, California) - Calcitriol ointment as adjunctive therapy to topical steroids is beneficial in continuing to suppress the re-emergence of plaque psoriasis. (medscape.com)
- Calcitriol ointment has been approved for use in Europe for many years and was approved by the US Food and Drug Administration last month. (medscape.com)
- Calcitriol ointment is used to treat mild to moderate psoriasis (a skin disease in which red, scaly patches form on some areas of the body). (epnet.com)
- Calcitriol comes as an ointment to apply to the skin. (epnet.com)
- Apply calcitriol ointment at around the same times every day. (epnet.com)
- Apply calcitriol ointment exactly as directed. (epnet.com)
- Do not use more than two tubes of calcitriol ointment per week. (epnet.com)
- Apply calcitriol ointment to the areas of skin affected by psoriasis. (epnet.com)
- Do not apply calcitriol ointment to healthy skin or anywhere on your face, eyes, lips, or vagina. (epnet.com)
- Do not cover the skin where you applied calcitriol ointment with a bandage or dressing unless your doctor tells you that you should. (epnet.com)
- Wash your hands well with soap and water after you apply calcitriol ointment. (epnet.com)
- Many other medications may also interact with calcitriol ointment, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list. (epnet.com)
- Calcitriol ointment may make your skin sensitive to sunlight. (epnet.com)
- Calcitriol ointment may cause side effects. (epnet.com)
- Do not freeze or refrigerate calcitriol ointment. (epnet.com)
- Therefore, higher doses of calcitriol may be necessary if these drugs are administered simultaneously. (mims.com)
- Calcitriol protects against the dopamine- and serotonin-depleting effects of neurotoxic doses of methanphetamine. (bvsalud.org)
- High oral doses of alpha calcitriol and calcium with i.v. infusion of high calcium doses were instituted, altogether sufficient to maintain only mild hypocalcaemia. (bioscientifica.com)
- Serum calcium was kept stable close to the low normal range by high doses of oral alpha calcitriol and calcium. (bioscientifica.com)
- Here, we used a mouse model (Jak1S645P+/- ) that resembles a constitutive activating mutation of the Jak1/Stat3 signaling pathway in humans, and shows altered mineral metabolism, with higher fibroblast growth factor 23 (FGF23) levels, lower PTH levels, and higher calcitriol levels. (uzh.ch)
- The higher calcitriol levels are probably due to extrarenal calcitriol production. (uzh.ch)
- To our knowledge, no previous studies have assessed calcitriol levels in children with CKD. (paediatricaindonesiana.org)
- Objective To assess calcitriol levels in children with CKD according to disease stage and other characteristics. (paediatricaindonesiana.org)
- Univariate and multivariate analyses were conducted to determine the association between calcitriol levels with disease stage and other characteristics. (paediatricaindonesiana.org)
- Results The overall mean calcitriol level of our subjects was 108.77 (SD 10.79) pmol/L. Mean levels at each CKD stage from I to V were 164.28 (SD 160.90), 94.14 (SD 50.63), 72.16 (SD 13.18), 62.92 (SD 4.87), and 67.51 (SD 4.87) pmol/L, respectively. (paediatricaindonesiana.org)
- Calcitriol levels did not differ significantly by CKD stage (P=0.114) when each stage from I to V was considered separately. (paediatricaindonesiana.org)
- There was no significant difference in calcitriol levels by growth characteristics (P=0.944), etiology (P=0.311), or anemic status (P=0.104). (paediatricaindonesiana.org)
- However, low calcitriol levels were found in all subjects with advanced stage CKD, compared to 63.6% subjects with early stage CKD (P=0.004). (paediatricaindonesiana.org)
- Mean calcitriol levels were significantly lower in CKD stage IV (P=0.049) and stage V (P=0.027) compared to stage I. (paediatricaindonesiana.org)
- Calcitriol levels are significantly lower in advanced stage than in early stage CKD. (paediatricaindonesiana.org)
- This was supported by calcitriol being without effect on pERK levels elevated by the action of TNF-α. (bvsalud.org)
- AAD 2009: Calcitriol Maintains Suppression of Psoriasis - Medscape - Mar 17, 2009. (medscape.com)
- numerous factors of the Calcitriol (CAS 32222-06-3) business just like the offer chain state of affairs, business standards, import/export details also are mentioned in world Calcitriol (CAS 32222-06-3) Market 2018 report. (timesofkabul.com)
- In conclusion, world Calcitriol (CAS 32222-06-3) market 2018 report presents the descriptive analysis of the parent market supported elite players, present, past and artistic movement information which is able to function a profitable guide for all the Calcitriol (CAS 32222-06-3) business competitors. (timesofkabul.com)
- Calcitriol has active ingredients of calcitriol . (ehealthme.com)
- Calcitriol is contraindicated in patients with known hypersensitivity to any of its ingredients. (kjhbazar.com)
- If you become pregnant while taking calcitriol, call your doctor. (medlineplus.gov)
- https://www.selleckchem.com/products/Calcitriol-(R. (uchatoo.com)
- While you are taking calcitriol, it is important that you follow any dietary suggestions your doctor has provided. (pharmachoice.com)
- You can tell from the photographs that some patients did continue to improve during the last 8 weeks of the study," after the steroids were stopped and calcitriol was used, she told Medscape Dermatology . (medscape.com)
- Un groupe de 69 patients atteints de diabète de type 1 et 45 témoins en bonne santé sans lien entre eux ont été recrutés pour cette étude. (who.int)