Receptors, Calcitonin: Cell surface proteins that bind calcitonin and trigger intracellular changes which influence the behavior of cells. Calcitonin receptors outside the nervous system mediate the role of calcitonin in calcium homeostasis. The role of calcitonin receptors in the brain is not well understood.Calcitonin: A peptide hormone that lowers calcium concentration in the blood. In humans, it is released by thyroid cells and acts to decrease the formation and absorptive activity of osteoclasts. Its role in regulating plasma calcium is much greater in children and in certain diseases than in normal adults.Receptors, Islet Amyloid Polypeptide: G-protein coupled receptors that are formed through the dimerization of the CALCITONIN RECEPTOR with a RECEPTOR ACTIVITY-MODIFYING PROTEIN. Their affinity for ISLET AMYLOID POLYPEPTIDE is dependent upon which of several receptor activity-modifying protein subtypes they are bound to.Calcitonin Gene-Related Peptide: Calcitonin gene-related peptide. A 37-amino acid peptide derived from the calcitonin gene. It occurs as a result of alternative processing of mRNA from the calcitonin gene. The neuropeptide is widely distributed in neural tissue of the brain, gut, perivascular nerves, and other tissue. The peptide produces multiple biological effects and has both circulatory and neurotransmitter modes of action. In particular, it is a potent endogenous vasodilator.Receptor Activity-Modifying Proteins: A family of proteins that bind to CELL SURFACE RECEPTORS and alter their specificity, signaling mechanism, or mode of intracellular transport.Receptor Activity-Modifying Protein 1: A receptor activity-modifying protein that is a subunit of specific G-PROTEIN COUPLED RECEPTORS. The CALCITONIN GENE-RELATED PEPTIDE RECEPTOR is formed from a dimer of this protein and CALCITONIN RECEPTOR-LIKE PROTEIN, while an isoform of the ISLET AMYLOID POLYPEPTIDE RECEPTOR is formed from this protein dimerizing with the CALCITONIN RECEPTOR.Receptors, Calcitonin Gene-Related Peptide: Cell surface proteins that bind CALCITONIN GENE-RELATED PEPTIDE with high affinity and trigger intracellular changes which influence the behavior of cells. CGRP receptors are present in both the CENTRAL NERVOUS SYSTEM and the periphery. They are formed via the heterodimerization of the CALCITONIN RECEPTOR-LIKE PROTEIN and RECEPTOR ACTIVITY-MODIFYING PROTEIN 1.Calcitonin Receptor-Like Protein: A receptor protein that is associated with RECEPTOR ACTIVITY-MODIFYING PROTEINS. When bound to RECEPTOR ACTIVITY-MODIFYING PROTEIN 1 it forms the CALCITONIN GENE-RELATED RECEPTOR. When bound to RECEPTOR ACTIVITY-MODIFYING PROTEIN 2 or RECEPTOR ACTIVITY-MODIFYING PROTEIN 3 it forms the ADRENOMEDULLIN RECEPTOR.Receptor Activity-Modifying Protein 3: A receptor activity-modifying protein that heterodimerizes with CALCITONIN RECEPTOR-LIKE PROTEIN to form the ADRENOMEDULLIN RECEPTOR. In addition, an isoform of the ISLET AMYLOID POLYPEPTIDE RECEPTOR is formed from this protein dimerizing with the CALCITONIN RECEPTOR.Salmon: Fish of the genera ONCORHYNCHUS and Salmo in the family SALMONIDAE. They are anadromous game fish, frequenting the coastal waters of both the North Atlantic and Pacific. They are known for their gameness as a sport fish and for the quality of their flesh as a table fish. (Webster, 3d ed).Osteoclasts: A large multinuclear cell associated with the BONE RESORPTION. An odontoclast, also called cementoclast, is cytomorphologically the same as an osteoclast and is involved in CEMENTUM resorption.Receptor Activity-Modifying Protein 2: A receptor activity-modifying protein that heterodimerizes with CALCITONIN RECEPTOR-LIKE PROTEIN to form the ADRENOMEDULLIN RECEPTOR. In addition, an isoform of the ISLET AMYLOID POLYPEPTIDE RECEPTOR is formed from this protein dimerizing with the CALCITONIN RECEPTOR.Islet Amyloid Polypeptide: A pancreatic beta-cell hormone that is co-secreted with INSULIN. It displays an anorectic effect on nutrient metabolism by inhibiting gastric acid secretion, gastric emptying and postprandial GLUCAGON secretion. Islet amyloid polypeptide can fold into AMYLOID FIBRILS that have been found as a major constituent of pancreatic AMYLOID DEPOSITS.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Cyclic AMP: An adenine nucleotide containing one phosphate group which is esterified to both the 3'- and 5'-positions of the sugar moiety. It is a second messenger and a key intracellular regulator, functioning as a mediator of activity for a number of hormones, including epinephrine, glucagon, and ACTH.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Receptors, Peptide: Cell surface receptors that bind peptide messengers with high affinity and regulate intracellular signals which influence the behavior of cells.Acid Phosphatase: An enzyme that catalyzes the conversion of an orthophosphoric monoester and water to an alcohol and orthophosphate. EC 3.1.3.2.COS Cells: CELL LINES derived from the CV-1 cell line by transformation with a replication origin defective mutant of SV40 VIRUS, which codes for wild type large T antigen (ANTIGENS, POLYOMAVIRUS TRANSFORMING). They are used for transfection and cloning. (The CV-1 cell line was derived from the kidney of an adult male African green monkey (CERCOPITHECUS AETHIOPS).)Bone Resorption: Bone loss due to osteoclastic activity.RANK Ligand: A transmembrane protein belonging to the tumor necrosis factor superfamily that specifically binds RECEPTOR ACTIVATOR OF NUCLEAR FACTOR-KAPPA B and OSTEOPROTEGERIN. It plays an important role in regulating OSTEOCLAST differentiation and activation.Sequence Homology, Amino Acid: The degree of similarity between sequences of amino acids. This information is useful for the analyzing genetic relatedness of proteins and species.Amyloid: A fibrous protein complex that consists of proteins folded into a specific cross beta-pleated sheet structure. This fibrillar structure has been found as an alternative folding pattern for a variety of functional proteins. Deposits of amyloid in the form of AMYLOID PLAQUES are associated with a variety of degenerative diseases. The amyloid structure has also been found in a number of functional proteins that are unrelated to disease.Intracellular Signaling Peptides and Proteins: Proteins and peptides that are involved in SIGNAL TRANSDUCTION within the cell. Included here are peptides and proteins that regulate the activity of TRANSCRIPTION FACTORS and cellular processes in response to signals from CELL SURFACE RECEPTORS. Intracellular signaling peptide and proteins may be part of an enzymatic signaling cascade or act through binding to and modifying the action of other signaling factors.Cercopithecus aethiops: A species of CERCOPITHECUS containing three subspecies: C. tantalus, C. pygerythrus, and C. sabeus. They are found in the forests and savannah of Africa. The African green monkey (C. pygerythrus) is the natural host of SIMIAN IMMUNODEFICIENCY VIRUS and is used in AIDS research.Cloning, Molecular: The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.Cell Line: Established cell cultures that have the potential to propagate indefinitely.Receptors, Cell Surface: Cell surface proteins that bind signalling molecules external to the cell with high affinity and convert this extracellular event into one or more intracellular signals that alter the behavior of the target cell (From Alberts, Molecular Biology of the Cell, 2nd ed, pp693-5). Cell surface receptors, unlike enzymes, do not chemically alter their ligands.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Membrane Proteins: Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors.Peptides: Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.Receptor Activator of Nuclear Factor-kappa B: A tumor necrosis factor receptor family member that is specific for RANK LIGAND and plays a role in bone homeostasis by regulating osteoclastogenesis. It is also expressed on DENDRITIC CELLS where it plays a role in regulating dendritic cell survival. Signaling by the activated receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.Binding, Competitive: The interaction of two or more substrates or ligands with the same binding site. The displacement of one by the other is used in quantitative and selective affinity measurements.Transfection: The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.RNA, Messenger: RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.Protein Binding: The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.Cells, Cultured: Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.Adenylate Cyclase Toxin: One of the virulence factors produced by virulent BORDETELLA organisms. It is a bifunctional protein with both ADENYLYL CYCLASES and hemolysin components.Hominidae: Family of the suborder HAPLORHINI (Anthropoidea) comprising bipedal primate MAMMALS. It includes modern man (HOMO SAPIENS) and the great apes: gorillas (GORILLA GORILLA), chimpanzees (PAN PANISCUS and PAN TROGLODYTES), and orangutans (PONGO PYGMAEUS).Clone Cells: A group of genetically identical cells all descended from a single common ancestral cell by mitosis in eukaryotes or by binary fission in prokaryotes. Clone cells also include populations of recombinant DNA molecules all carrying the same inserted sequence. (From King & Stansfield, Dictionary of Genetics, 4th ed)Pasteurellosis, Pneumonic: Bovine respiratory disease found in animals that have been shipped or exposed to CATTLE recently transported. The major agent responsible for the disease is MANNHEIMIA HAEMOLYTICA and less commonly, PASTEURELLA MULTOCIDA or HAEMOPHILUS SOMNUS. All three agents are normal inhabitants of the bovine nasal pharyngeal mucosa but not the LUNG. They are considered opportunistic pathogens following STRESS, PHYSIOLOGICAL and/or a viral infection. The resulting bacterial fibrinous BRONCHOPNEUMONIA is often fatal.Ships: Large vessels propelled by power or sail used for transportation on rivers, seas, oceans, or other navigable waters. Boats are smaller vessels propelled by oars, paddles, sail, or power; they may or may not have a deck.Trinitrobenzenesulfonic Acid: A reagent that is used to neutralize peptide terminal amino groups.Colitis: Inflammation of the COLON section of the large intestine (INTESTINE, LARGE), usually with symptoms such as DIARRHEA (often with blood and mucus), ABDOMINAL PAIN, and FEVER.Adrenomedullin: A 52-amino acid peptide with multi-functions. It was originally isolated from PHEOCHROMOCYTOMA and ADRENAL MEDULLA but is widely distributed throughout the body including lung and kidney tissues. Besides controlling fluid-electrolyte homeostasis, adrenomedullin is a potent vasodilator and can inhibit pituitary ACTH secretion.Colitis, Ulcerative: Inflammation of the COLON that is predominantly confined to the MUCOSA. Its major symptoms include DIARRHEA, rectal BLEEDING, the passage of MUCUS, and ABDOMINAL PAIN.Colon: The segment of LARGE INTESTINE between the CECUM and the RECTUM. It includes the ASCENDING COLON; the TRANSVERSE COLON; the DESCENDING COLON; and the SIGMOID COLON.PubMed: A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.BooksPublishing: "The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.MEDLINE: The premier bibliographic database of the NATIONAL LIBRARY OF MEDICINE. MEDLINE® (MEDLARS Online) is the primary subset of PUBMED and can be searched on NLM's Web site in PubMed or the NLM Gateway. MEDLINE references are indexed with MEDICAL SUBJECT HEADINGS (MeSH).

Co-expression of prepro-adrenomedullin with a putative adrenomedullin receptor gene in vascular smooth muscle. (1/119)

The prepro-adrenomedullin (prepro-AM) gene encodes several biologically active peptides, including the potent vasodilator AM. At least part of the vasodilator action of AM appears to be mediated via interactions with receptors on vascular smooth muscle cells (VSMC); however, the specific receptors involved are not known. The aim of the present study was to identify putative AM receptor genes that are co-expressed with AM in cultured rat aortic VSMC that may mediate the actions of AM. AM mRNA was shown to be expressed in rat aortic VSMC cultures. In acute (4 h) secretion studies, only 20% of the total immunoreactive AM was intracellular, with the majority (80%) found in the medium, indicating active release of AM peptide from VSMC. Using highly specific ribonuclease protection analysis, mRNAs encoding three putative AM receptors [L1, calcitonin-receptor-like receptor (CRLR) and RDC1] were shown to be present at high concentrations in RNA extracts from lung. In cultured VSMC, however, whereas RDC1 mRNA was expressed at relatively high concentrations, transcripts encoding CRLR and L1 were not detected. The co-expression of prepro-AM mRNA with the RDC1 receptor implies that AM may act in a localized manner via this receptor to modulate VSMC function.  (+info)

The RAMP2/CRLR complex is a functional adrenomedullin receptor in human endothelial and vascular smooth muscle cells. (2/119)

Adrenomedullin, a potently hypotensive peptide isolated from human pheochromocytoma, is known to elicit a rise in cAMP levels within mammalian endothelial and smooth muscle cells. Until now, however, little has been known about the adrenomedullin receptor. Recently, a group called receptor activity-modifying proteins that complex with the calcitonin receptor-like receptor, and thereby regulate its transport and ligand specificity, were identified. Here we show that mRNA for both the calcitonin receptor-like receptor and the receptor activity-modifying protein 2, but not the receptor activity-modifying protein 1 or receptor activity-modifying protein 3, are expressed in human endothelial and vascular smooth muscle cells. We also found that adrenomedullin increased cAMP levels in HeLa EBNA and 293 EBNA cells, expressing both the receptor activity-modifying protein 2 and calcitonin receptor-like receptor proteins. Thus, the receptor activity-modifying protein 2/calcitonin receptor-like receptor complex apparently serves as a functional adrenomedullin receptor in human endothelial and vascular smooth muscle cells.  (+info)

The amino terminus of receptor activity modifying proteins is a critical determinant of glycosylation state and ligand binding of calcitonin receptor-like receptor. (3/119)

The calcitonin receptor-like receptor (CRLR) can function as either a receptor for calcitonin gene-related peptide (CGRP) or for adrenomedullin (ADM), depending upon the coexpression of a novel family of single transmembrane proteins, which we have called receptor activity modifying proteins or RAMPs. RAMPs 1, 2, and 3 transport CRLR to the plasma membrane with similar efficiencies, however RAMP1 presents CRLR as a terminally glycosylated, mature glycoprotein and a CGRP receptor, whereas RAMPs 2 and 3 present CRLR as an immature, core glycosylated ADM receptor. Characterization of the RAMP2/CRLR and RAMP3/CRLR receptors in HEK293T cells by radioligand binding (125I-ADM as radioligand), functional assay (cAMP measurement), or biochemical analysis (SDS-polyacrylamide gel electrophoresis) revealed them to be indistinguishable, even though RAMPs 2 and 3 share only 30% identity. Chimeric proteins were created with the transmembrane and cytosolic portions of RAMP1 associated with the amino terminus of RAMP2 (RAMP2/1) and vice versa (RAMP1/2). Coexpression of RAMP2/1 with CRLR formed a core glycosylated ADM receptor, whereas the RAMP1/2 chimera generated both core glycosylated and mature forms of CRLR and enabled both ADM and CGRP receptor binding. Hence, the glycosylation state of CRLR appears to correlate with its pharmacology.  (+info)

Mammalian calcitonin receptor-like receptor/receptor activity modifying protein complexes define calcitonin gene-related peptide and adrenomedullin receptors in Drosophila Schneider 2 cells. (4/119)

Differential glycosylation of human and rat (r) calcitonin (CT) receptor-like receptors (CRLR) as a result of interactions with accessory receptor activity-modifying proteins (RAMP)1 or -2 was considered to define CT gene-related peptide (CGRP) or adrenomedullin (ADM) receptors in mammalian cells. Here, Drosophila Schneider (S2) cells stably co-expressed rCRLR and RAMP1 or -2 as functional CGRP or ADM receptors. Different from mammalian cells, rCRLR expressed in S2 cells are uniformly glycosylated proteins independent of RAMP1 or RAMP2. Bis(sulfosuccinimidyl)suberate cross-linking revealed receptor components with the size of rCRLR, increased by the molecular weights of the corresponding RAMPs and [(125)I]CGRP or [(125)I]ADM. In conclusion, [(125)I]CGRP/rCRLR/RAMP1 and [(125)I]ADM/rCRLR/RAMP2 complexes have been recognized in Drosophila S2 cells.  (+info)

CGRP and adrenomedullin binding correlates with transcript levels for calcitonin receptor-like receptor (CRLR) and receptor activity modifying proteins (RAMPs) in rat tissues. (5/119)

1. Putative receptors for CGRP and adrenomedullin have been investigated in the rat. Calcitonin Receptor-Like Receptor (CRLR), in combination with Receptor Activity Modifying Proteins (RAMPs) is hypothesized to bind either CGRP or adrenomedullin. The receptors known as RDC1 and L1 have also been shown to bind CGRP and adrenomedullin respectively. 2. In this study it is shown that rat CRLR cDNA specifies a CGRP receptor when co-transfected with RAMP-1 cDNA and an adrenomedullin receptor when co-transfected with either RAMP-2 or RAMP-3 cDNA in human embryonic kidney 293 cells. 3. CRLR, RAMP, RCD1 and L1 mRNA levels and CGRP and adrenomedullin receptor densities have been measured and correlated with each other in eight rat tissues selected for their distinctive patterns of CGRP and adrenomedullin binding. 4. The data are consistent with the predictions of the CRLR/RAMP model. CGRP binding correlates well with RAMP-1 mRNA levels (R=1.0, P=0.007), adrenomedullin binding shows a tendency to vary with RAMP-2 mRNA levels (R=0.85, P=0.14) and total binding is correlated with CRLR mRNA levels (R=0.94, P=0.03). The data do not support the hypothesis that RDC1 and L1 account for the majority of CGRP and adrenomedullin binding respectively.  (+info)

Visualization of the calcitonin receptor-like receptor and its receptor activity-modifying proteins during internalization and recycling. (6/119)

Expression of the calcitonin receptor-like receptor (CRLR) and its receptor activity modifying proteins (RAMPs) can produce calcitonin gene-related peptide (CGRP) receptors (CRLR/RAMP1) and adrenomedullin (AM) receptors (CRLR/RAMP2 or -3). A chimera of the CRLR and green fluorescent protein (CRLR-GFP) was used to study receptor localization and trafficking in stably transduced HEK 293 cells, with or without co-transfection of RAMPs. CRLR-GFP failed to generate responses to CGRP or AM without RAMPs. Furthermore, CRLR-GFP was not found in the plasma membrane and its localization was unchanged after agonist exposure. When stably coexpressed with RAMPs, CRLR-GFP appeared on the cell surface and was fully active in intracellular cAMP production and calcium mobilization. Agonist-mediated internalization of CRLR-GFP was observed in RAMP1/CGRP or AM, RAMP2/AM, and RAMP3/AM, which occurred with similar kinetics, indicating the existence of ligand-specific regulation of CRLR internalization by RAMPs. This internalization was strongly inhibited by hypertonic medium (0.45 m sucrose) and paralleled localization of rhodamine-labeled transferrin, suggesting that CRLR endocytosis occurred predominantly through a clathrin-dependent pathway. A significant proportion of CRLR was targeted to lysosomes upon binding of the ligands, and recycling of the internalized CRLR was not efficient. In HEK 293 cells stably expressing CRLR-GFP and Myc-RAMPs, these rhodamine-labeled RAMPs were co-localized with CRLR-GFP in the presence and absence of the ligands. Thus, the CRLR is endocytosed together with RAMPs via clathrin-coated vesicles, and both the internalized molecules are targeted to the degradative pathway.  (+info)

Adrenomedullin inhibits spontaneous and bradykinin-induced but not oxytocin- or prostaglandin F(2alpha)-induced periodic contraction of rat uterus. (7/119)

In isolated rat uterine strips, adrenomedullin (AM) inhibited the spontaneous periodic contraction in a concentration-dependent manner (IC(50)=22.3+/-0.7 nM). The inhibitory effect of AM was prevented by either AM(22-52), a putative antagonist for AM receptors, or calcitonin gene-related peptide (CGRP)(8-37), a putative antagonist for CGRP receptors. AM also attenuated bradykinin (BK)-induced periodic uterine contraction, which was blocked by AM(22-52) or CGRP(8-37), whereas AM had no effect on the periodic contraction caused by oxytocin or prostaglandin F(2alpha) (PGF(2alpha)). RT-PCR analysis showed that mRNAs for calcitonin receptor-like receptor (CRLR), receptor-activity-modifying protein (RAMP)1, RAMP2 and RAMP3 were expressed in the rat uterus. These results demonstrate that AM selectively inhibits spontaneous and BK-induced periodic contraction via activating receptors for AM and CGRP.  (+info)

Glycosylation of the calcitonin receptor-like receptor at Asn(60) or Asn(112) is important for cell surface expression. (8/119)

The human calcitonin (CT) receptor-like receptor (hCRLR) of the B family of G protein-coupled receptors is N-glycosylated and associates with receptor-activity-modifying proteins for functional interaction with CT gene-related peptide (CGRP) or adrenomedullin (ADM), respectively. Three putative N-glycosylation sites Asn(60), Asn(112) and Asn(117) are present in the amino-terminal extracellular domain of the hCRLR. Tunicamycin dose-dependently inhibited the glycosylation of a myc-tagged hCRLR and in parallel specific [(125)I]CGRP and -ADM binding. Similarly, the double mutant myc-hCRLR(N60,112T) exhibited minimal N-glycosidase F sensitive glycosylation, presumably at the third Asn(117), and the cell surface expression and specific radioligand binding were impaired. Substitution of the Asn(117) by Thr abolished CGRP and ADM binding in the face of intact N-glycosylation and cell surface expression.  (+info)

*Debbie Lucy Hay

Investigation of the calcitonin receptor-like receptor and receptor activity modifying proteins' at Imperial College London. ... "Pharmacological discrimination of calcitonin receptor: receptor activity-modifying protein complexes." Molecular pharmacology ... "Regulation of signal transduction by calcitonin gene-related peptide receptors." Trends in pharmacological sciences 31, no. 10 ... "CL/RAMP2 and CL/RAMP3 produce pharmacologically distinct adrenomedullin receptors: a comparison of effects of adrenomedullin22- ...

*RAMP2

2002). "Immunohistochemical localization of calcitonin receptor-like receptor and receptor activity-modifying proteins in the ... sensitive adrenomedullin receptors derived from co-expression of calcitonin receptor with receptor activity-modifying proteins ... 2006). "Distinct receptor activity-modifying protein domains differentially modulate interaction with calcitonin receptors". ... RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven ...

*Calcitonin receptor

The calcitonin receptor (CT) is a G protein-coupled receptor that binds the peptide hormone calcitonin and is involved in ... "Multiple amylin receptors arise from receptor activity-modifying protein interaction with the calcitonin receptor gene product ... The function of the CT receptor protein is modified through its interaction with Receptor activity-modifying proteins (RAMPs), ... "Calcitonin Receptors: Introduction". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical ...

*PTK2

... family member HEF1 downstream of the G protein-coupled calcitonin receptor. Calcitonin induces the association of HEF1, ... FAK is a highly conserved, non-receptor tyrosine kinase originally identified as a substrate for the oncogene protein tyrosine ... PTK2 protein tyrosine kinase 2 (PTK2), also known as focal adhesion kinase (FAK), is a protein that, in humans, is encoded by ... The encoded protein is a member of the FAK subfamily of protein tyrosine kinases that included PYK2, but lacks significant ...

*CALCRL

Calcitonin receptor-like (CALCRL), also known as the calcitonin receptor-like receptor (CRLR), is a human protein. The protein ... "Mammalian calcitonin receptor-like receptor/receptor activity modifying protein complexes define calcitonin gene-related ... Sams A, Jansen-Olesen I (1999). "Expression of calcitonin receptor-like receptor and receptor-activity-modifying proteins in ... 2001). "Differential and cell-specific expression of calcitonin receptor-like receptor and receptor activity modifying proteins ...

*ADM2

... peptide family peptide acting through the calcitonin receptor-like receptor/receptor activity-modifying protein receptor ... ADM2 is a protein that in humans is encoded by the ADM2 gene. ADM2 belongs to a family of calcitonin (MIM 114130)-related ... 2004). "Intermedin is a calcitonin/calcitonin gene-related ...

*Amylin

All three complexes contain the calcitonin receptor at the core, plus one of three receptor activity-modifying proteins, RAMP1 ... Amylin also acts in bone metabolism, along with the related peptides calcitonin and calcitonin gene related peptide. Rodent ... 1991). "Solution structures of calcitonin-gene-related-peptide analogues of calcitonin-gene-related peptide and amylin". ... "A novel peptide in the calcitonin gene related peptide family as an amyloid fibril protein in the endocrine pancreas". Biochem ...

*GPR61

This gene belongs to the G-protein coupled receptor 1 family. G protein-coupled receptors contain 7 transmembrane domains and ... 2005). "A key role for transmembrane prolines in calcitonin receptor-like receptor agonist binding and signalling: implications ... Probable G-protein coupled receptor 61 is a protein that in humans is encoded by the GPR61 gene. ... Cikos S, Gregor P, Koppel J (Nov 2001). "Cloning of a novel biogenic amine receptor-like G protein-coupled receptor expressed ...

*RCP9

2002). "Characterization of calcitonin gene-related peptide (CGRP) receptors and their receptor-activity-modifying proteins ( ... "Entrez Gene: RCP9 calcitonin gene-related peptide-receptor component protein". Yallampalli C, Chauhan M, Thota CS, et al. (2003 ... a novel protein required for signal transduction at calcitonin gene-related peptide and adrenomedullin receptors". J. Biol. ... "Testes exhibit elevated expression of calcitonin gene-related peptide receptor component protein". Endocrinology. 140 (3): 1459 ...

*Calcitonin gene-related peptide

CGRP mediates its effects through a heteromeric receptor composed of a G protein-coupled receptor called calcitonin receptor- ... and a receptor activity-modifying protein (RAMP1). CGRP receptors are found throughout the body, suggesting that the protein ... The mammalian calcitonin gene-related peptides, adrenomedullin, amylin, and calcitonin receptors". Pharmacol Rev. 54 (2): 233- ... Botulinum toxin type A is able to prevent stimulated release of CGRP through the cleavage of SNAP-25 protein. Receptor ...

*RAMP3

... peptide family peptide acting through the calcitonin receptor-like receptor/receptor activity-modifying protein receptor ... sensitive adrenomedullin receptors derived from co-expression of calcitonin receptor with receptor activity-modifying proteins ... RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven ... called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular ...

*RAMP1

2007). "Post-endocytic sorting of calcitonin receptor-like receptor and receptor activity-modifying protein 1". J. Biol. Chem. ... protein, where heteromerisation of RAMP1 with CT converts CT from a calcitonin receptor to the amylin receptor AMY1 Receptor ... sensitive adrenomedullin receptors derived from co-expression of calcitonin receptor with receptor activity-modifying proteins ... "The extracellular domain of receptor activity-modifying protein 1 is sufficient for calcitonin receptor-like receptor function ...

*Adrenomedullin

... exerts its actions through combinations of the calcitonin receptor like receptor (CALCRL) or CLR; and either (Receptor activity ... Dackor R, Fritz-Six K, Smithies O, Caron K (June 2007). "Receptor activity-modifying proteins 2 and 3 have distinct ... "RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor". Nature. 393 (6683): 333-9. doi: ... Before the discovery of the RAMPs and the identification of heteromeric receptors for the calcitonin family of peptides, a ...

*Receptor activity-modifying protein

Association of RAMPs with either the CT or CALCRL proteins forms 6 different receptors from the calcitonin receptor family: ... When associated with the Calcitonin receptor (CTR) or Calcitonin receptor-like (CALCRL) (below), RAMPs can change the ... Receptor activity-modifying proteins (RAMPs) are a class of protein that interact with and modulate the activities of several ... Class B G protein-coupled receptors including the receptors for secretin, calcitonin (CT), glucagon, and vasoactive intestinal ...

*Calcitonin

The calcitonin receptor, found on osteoclasts, and in the kidney and regions of the brain, is a G protein-coupled receptor, ... The Calcitonin Protein Calcitonin at the US National Library of Medicine Medical Subject Headings (MeSH). ... It belongs to the calcitonin-like protein family. Calcitonin is formed by the proteolytic cleavage of a larger prepropeptide, ... Osteoblasts do not have calcitonin receptors and are therefore not directly affected by calcitonin levels. However, since bone ...

*Apolipoprotein B

... with lipoprotein receptors. It is the dominant ApoB protein in the small intestine of most mammals. It is a key protein in the ... ApoB has been shown to interact with apo(a), PPIB, Calcitonin receptor and HSP90B1. Interaction of ApoB with proteoglycans, ... receptors. The net result is shunting of LDL particles to these scavenger receptors. Scavenger receptors typically are found on ... However editing results in a protein lacking this LDL-R binding region of the protein. This alters the function of the protein ...

*Arrestin beta 2

Lefkowitz RJ (July 1998). "G protein-coupled receptors. III. New roles for receptor kinases and beta-arrestins in receptor ... "Agonist-promoted internalization of a ternary complex between calcitonin receptor-like receptor, receptor activity-modifying ... arrestin protein family are thought to participate in agonist-mediated desensitization of G protein-coupled receptors and cause ... "Differential roles of arrestin-2 interaction with clathrin and adaptor protein 2 in G protein-coupled receptor trafficking". ...

*Index of biochemistry articles

... calcitonin receptor - calcitriol receptor - calcium channel - calcium signaling - calcium-binding protein - Calmodulin - ... prostaglandin receptor - protein - protein biosynthesis - Protein Data Bank - protein design - protein expression - protein ... fusion oncogene protein - G protein - G protein-coupled receptor - G3P - GABA - GABA receptor - GABA-A receptor - gag-onc ... protein P16 - protein P34cdc2 - protein precursor - protein structure prediction - protein subunit - protein synthesis - ...

*Glucagon receptor

... modifying protein-directed G protein signaling specificity for the calcitonin gene-related peptide family of receptors receptor ... The glucagon receptor is a 62 kDa protein that is activated by glucagon and is a member of the class B G-protein coupled family ... the Receptor activity-modifying protein, and the G-protein C-terminus has been determined using a computational and ... "Structure-function of the glucagon receptor family of G protein-coupled receptors: the glucagon, GIP, GLP-1, and GLP-2 ...

*Gq alpha subunit

... the G-protein coupled receptors: 5-HT2 serotonergic receptors Alpha-1 adrenergic receptor Vasopressin type 1 receptors: 1A and ... 1B Angiotensin II receptor type 1 Calcitonin receptor Histamine H1 receptor Metabotropic glutamate receptor, Group I M1, M3, ... such as M3 receptor. The common polybasic domain in the C-tail of Gq-coupled receptors is necessary for the receptor-G protein ... Further reading: function of protein kinase C From modulatory neurotransmitter receptors (amine receptors belonging to ...

*Secretin receptor family

The secretin-receptor family GPCRs include vasoactive intestinal peptide receptors and receptors for secretin, calcitonin and ... the secretin-receptor family or family 2 of the G-protein-coupled receptors (GPCR). Many secretin receptors are regulated by ... Pituitary adenylate cyclase-activating polypeptide type 1 receptor InterPro: IPR002285 PACAPR (ADCYAP1R1) Calcitonin receptor ... required for specific G-protein coupling. Diuretic hormone receptor InterPro: IPR002001 Ig-hepta receptor InterPro: IPR008078 ...

*G protein

Calcitonin - Decreases blood calcium levels (via the calcitonin receptor in the intestines, bones, kidneys, and brain) Glucagon ... Whereas G proteins are activated by G protein-coupled receptors, they are inactivated by RGS proteins (for "Regulator of G ... Heterotrimeric G proteins, sometimes referred to as the "large" G proteins, are activated by G protein-coupled receptors and ... These include receptor antagonists, neurotransmitters, neurotransmitter reuptake, G protein-coupled receptors, G proteins, ...

*G protein-coupled receptor

... calcitonin, C5a anaphylatoxin, follicle-stimulating hormone (FSH), gonadotropin-releasing hormone (GnRH), neurokinin, ... 7TM receptors, heptahelical receptors, serpentine receptor, and G protein-linked receptors (GPLR), constitute a large protein ... G-protein-coupled receptor kinases (GRKs) are key modulators of G-protein-coupled receptor (GPCR) signaling. They constitute a ... G protein-coupled receptors database List of MeSH codes (D12.776) Metabotropic receptor Orphan receptor Pepducins, a class of ...

*Parathyroid hormone

PTH is secreted when [Ca2+] is decreased (Calcitonin is secreted when serum calcium levels are elevated). The G-protein coupled ... Free OPG competitively binds to RANKL as a decoy receptor, preventing RANKL from interacting with RANK, a receptor for RANKL. ... PTH was one of the first hormones to be shown to use the G-protein, adenylyl cyclase second messenger system. PTH reduces the ... While PTH acts to increase the concentration of ionic calcium (Ca2+) in the blood, calcitonin, a hormone produced by the ...

*AKTIP

"A human orphan calcitonin receptor-like structure". Biochem Biophys Res Commun. 206 (1): 341-7. doi:10.1006/bbrc.1995.1047. ... AKT-interacting protein is a protein that in humans is encoded by the AKTIP gene. The mouse homolog of this gene produces fused ... This protein interacts directly with serine/threonine kinase protein kinase B (PKB)/Akt and modulates PKB activity by enhancing ... Remy I, Michnick SW (2004). "Regulation of apoptosis by the Ft1 protein, a new modulator of protein kinase B/Akt". Mol. Cell. ...

*N-Arachidonoyl dopamine

... (NADA) is an endocannabinoid that acts as an agonist of the CB1 receptor and the transient receptor ... It can increase the TRPV1-mediated release of substance P and calcitonin gene-related peptide (CGRP) in rat dorsal spinal cord ... and activator protein 1 signaling pathways". Journal of Immunology. 172 (4): 2341-2351. doi:10.4049/jimmunol.172.4.2341. ISSN ... NADA was first described as a putative endocannabinoid (agonist for the CB1 receptor) in 2000 and was subsequently identified ...
Looking for online definition of calcitonin receptor-like receptor activity modifying protein 3 in the Medical Dictionary? calcitonin receptor-like receptor activity modifying protein 3 explanation free. What is calcitonin receptor-like receptor activity modifying protein 3? Meaning of calcitonin receptor-like receptor activity modifying protein 3 medical term. What does calcitonin receptor-like receptor activity modifying protein 3 mean?
Background: Vascular tumours such as Kaposis sarcoma and capillary haemangioma are characterised by abnormal vascularisation and proliferation of endothelial cells or neoplastic cells. Adrenomedullin, a potent vasodilative peptide, and its receptor, calcitonin receptor-like receptor (CRLR), play an important part in angiogenesis.. Aim: To establish whether this system also plays a part in vascular diseases, showing abnormal proliferation such as vascular tumours.. Methods: CRLR expression was investigated in several specimens of Kaposis sarcoma and other vascular tumours, using immunohistochemical analysis with a previously described CRLR-specific polyclonal antibody and reverse transcriptase-polymerase chain reaction.. Results: Intense and specific CRLR-immunoreactive staining of neoplastic cells was observed in all specimens, which was of greater intensity than similar staining of adjacent normal endothelium.. Conclusions: CRLR is expressed in vascular tumours and, with adrenomedullin, may ...
The calcitonin gene-related peptide (CGRP) receptor is a heterodimer of a family B G-protein-coupled receptor, calcitonin receptor-like receptor (CLR), and the accessory protein receptor activity modifying protein 1. It couples to Gs, but it is not known which intracellular loops mediate this. We have identified the boundaries of this loop based on the relative position and length of the juxtamembrane transmembrane regions 3 and 4. The loop has been analyzed by systematic mutagenesis of all residues to alanine, measuring cAMP accumulation, CGRP affinity, and receptor expression. Unlike rhodopsin, ICL2 of the CGRP receptor plays a part in the conformational switch after agonist interaction. His-216 and Lys-227 were essential for a functional CGRP-induced cAMP response. The effect of (H216A)CLR is due to a disruption to the cell surface transport or surface stability of the mutant receptor. In contrast, (K227A)CLR had wild-type expression and agonist affinity, suggesting a direct disruption to the ...
Combining with the neurotransmitter dopamine and activating adenylate cyclase via coupling to Gs to initiate a change in cell activity.
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Adrenomedullin兔多克隆抗体(ab125409)可与人样本反应并经WB实验严格验证。中国75%以上现货,所有产品均提供质保服务,可通过电话、电邮或微信获得本地专属技术支持。
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Title:Role of CGRP-Receptor Component Protein (RCP) in CLR/RAMP Function. VOLUME: 14 ISSUE: 5. Author(s):Ian M. Dickerson. Affiliation:University of Rochester, Department of Neurobiology & Anatomy, 601 Elmwood Avenue, Box 603, Rochester, NY 14642, USA.. Keywords:Calcitonin gene-related peptide, adrenomedullin, calcitonin-like receptor, receptor activity modifying protein, CGRP-receptor component protein, signal transduction, trafficking.. Abstract:The receptor for calcitonin gene-related peptide (CGRP) and adrenomedullin (AM) requires an intracellular peripheral membrane protein named CGRP-receptor component protein (RCP) for signaling. RCP is required for CGRP and AM receptor signaling, and it has recently been discovered that RCP enables signaling by binding directly to the receptor. RCP is present in most immortalized cell lines, but in vivo RCP expression is limited to specific subsets of cells, usually co-localizing with CGRP-containing neurons. RCP protein expression correlates with CGRP ...
Looking for online definition of CRLR or what CRLR stands for? CRLR is listed in the Worlds largest and most authoritative dictionary database of abbreviations and acronyms
History c-erbB2 a proto-oncogene coding epidermal development aspect receptor-like receptor also being a chemosensitivity/prognosis marker for gynecologic cancers may be involved with initiation of development of rat primordial follicles. mRNA was portrayed in ooplasm as well as the appearance of c-erbB2 reduced after transfection with c-erbB2 siRNA. Treatment with EGF in 50 ng/ml significantly increased c-erbB2 appearance and extra and principal follicle development in ovaries. This augmenting effect was remarkably inhibited by c-erbB2 siRNA transfection However. Furthermore folliculogenesis offset was obstructed by calphostin (5 × 10(-4) SP600125 mmol/L) and PD98059 SP600125 (5 × 10(-2) mmol/L) but both didnt down-regulate c-erbB2 appearance. On the other hand the expressions of p-ERK and p-PKC were reduced by c-erbB2 siRNA transfection obviously. Conclusions c-erbB2 initiates rat primordial follicle development via PKC and MAPK pathways recommending an important function of c-erbB2 in rat ...
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The RAMP project paves the way for a new approach on brain therapy and the development of brain-inspired computing architectures. Stefano Vassanelli tells us how EU funding made it a success.
At the age of sixty, Matthew is known as a strange, timid man. His painful shyness becomes paralyzing when he is forced to interact with women, and he spends most of his time away from people, working the land at Green Gables. Despite Matthews extreme shyness, Anne immediately appeals to him and sets him at ease. From the beginning, Matthew advocates for Anne. He expresses pride in all she does and seizes every opportunity to spoil her. Although when they adopt Anne Marilla makes Matthew promise not to interfere with the raising of the child, Matthew becomes increasingly involved in parental duties, especially when he feels Marilla is treating Anne too harshly. With his gentle persistence, he often wears away at Marilla until she agrees to let him and Anne have their way.. ...
Although transplanting mesenchymal stem cells can improve cardiac function and contribute to endothelial recovery in a damaged artery, mesenchymal stem cells may induce neointimal hyperplasia by directly or indirectly acting ...
Belilovsky on naproxen 250 mg: NSAIDS, like Naproxen have disadvantages in pregnancy.Naproxen Tablets, USP, 250 mg, are supplied as white, round,.Naproxen (brand names: Aleve, Naprosyn, and many others) is a nonsteroidal anti-inflammatory drug (NSAID) of the propionic acid class (the same class as ibuprofen.Explains the medication naproxen (Aleve, Naprosyn, Anaprox, Naprelan) a drug used for the management of mild to moderate pain, fever, and inflammation.It may cause an increased risk of serious and sometimes fatal heart and blood.RAMPs organize the spellbind and ligand specificity of the calcitonin- receptor-like receptor order 500 mg naproxen with mastercard arthritis diet.Naproxen works by reducing hormones that cause inflammation and pain in the body.. ❸-3-6} ...
We showed previously that activation of Gα14/16 by a variety of G protein-coupled receptors, including the δ-opioid, C5a, formyl peptide, and opioid receptor-like receptors (20, 21, 53), can lead to STAT3 Tyr705 phosphorylation within 15 min in HEK293 cells. In contrast, CCR1/Gα14/16-mediated Tyr705 phosphorylation of STAT3 was only detected after prolonged drug pretreatment. This discrepancy is puzzling, especially because the receptors were expressed in the same cellular background. Although we do not have a plausible explanation, it should be noted that delayed STAT3 Tyr705 phosphorylation is not unique to CCR1; it has been similarly observed with G16-coupled melatonin MT1 and MT2 receptors (36). Moreover, distinct temporal patterns of STAT3 phosphorylations at Tyr705 and Ser727 have been documented. In murine macrophage-like RAW 264.7 cells, STAT3 Ser727 phosphorylation induced by LPS can be observed at 5 min, whereas STAT3 Tyr705 phosphorylation requires 2 h of treatment (54). Likewise, ...
Supplementary MaterialsESM 1: (PDF 5671 kb) 12975_2017_555_MOESM1_ESM. medical procedures. The appearance of Compact disc31, -SMA, and myelin simple proteins (MBP) was buy Baricitinib evaluated by immunohistochemistry (IHC). Extra group of mice had been randomized to sham, BCAS, and BCAS+C-RIC. The cerebrovascular angioarchitecture was examined with micro-CT. RIC therapy for either 1 or 4?months improved CBF […]. ...
The IUPHAR/BPS Guide to Pharmacology. adrenomedullin 2/intermedin ligand page. Quantitative data and detailed annnotation of the targets of licensed and experimental drugs.
The IUPHAR/BPS Guide to Pharmacology. adrenomedullin 2/intermedin ligand page. Quantitative data and detailed annnotation of the targets of licensed and experimental drugs.
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Adrenomedullin promotes formation of xenografted endometrial tumors by stimulation of autocrine growth and angiogenesis.: The angiogenic peptide adrenomedullin
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Calcitonin drug-oligomer conjugates that include a calcitonin drug coupled to an oligomer including a single polyalkylene glycol moiety consisting of between 4 and 10 polyalkylene glycol subunits are disclosed. Pharmaceutical compositions including such conjugates and methods of treating bone disorders by administering such conjugates are also disclosed.
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This article discusses the various threading paradigms available under the .NET CLR, using C#.; Author: Gary J. Kuehn; Updated: 23 Dec 2004; Section: C / C++ Language; Chapter: Languages; Updated: 23 Dec 2004
ad hoc Reviewer for Journal of Investigative Dermatology, Experimental Dermatology, Journal Immunological Methods, Allergy, British Journal of Dermatology, Cancer Immunology Immunotherapy, International Archives of Allergy and Immunology, Acta Dermato-Venerologica, European Journal of Dermatology, Dermatology, Journal of Dermatological Science 1996 - ...
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The behavior of comparison with CLR types is not consistent. Im using beta4 on Windows: ,,, from System import * ,,, UInt64.Parse(0) == 0 False ,,, UInt32.Parse(0) == 0 False ,,, UInt16.Parse(0) == 0 False ,,, Int16.Parse(0) == 0 False ,,, Int32.Parse(0) == 0 True ,,, Int64.Parse(0) == 0 True ,,, -arman ...
article{06e909fb-92e7-430e-8ee0-7c65477569b1, abstract = {,p,The calcitonin receptor (CTR) is relevant to three hormonal systems: amylin, calcitonin, and calcitonin gene-related peptide (CGRP). Receptors for amylin and calcitonin are targets for treating obesity, diabetes, and bone disorders. CGRP receptors represent a target for pain and migraine. Amylin receptors (AMY) are a heterodimer formed by the coexpression of CTR with receptor activity-modifying proteins (RAMPs). CTR with RAMP1 responds potently to both amylin and CGRP. The brain stem is a major site of action for circulating amylin and is a rich site of CGRP binding. This study aimed to enhance our understanding of these hormone systems by mapping CTR expression in the human brain stem, specifically the medulla oblongata. Widespread CTR-like immunoreactivity was observed throughout the medulla. Dense CTR staining was noted in several discrete nuclei, including the nucleus of the solitary tract, the hypoglossal nucleus, the cuneate ...
BACKGROUND: Monoclonal antibodies (mAbs) towards CGRP or the CGRP receptor show good prophylactic antimigraine efficacy. However, their site of action is still elusive. Due to lack of passage of mAbs across the blood-brain barrier the trigeminal system has been suggested a possible site of action because it lacks blood-brain barrier and hence is available to circulating molecules. The trigeminal ganglion (TG) harbors two types of neurons; half of which store CGRP and the rest that express CGRP receptor elements (CLR/RAMP1). METHODS: With specific immunohistochemistry methods, we demonstrated the localization of CGRP, CLR, RAMP1, and their locations related to expression of the paranodal marker contactin-associated protein 1 (CASPR). Furthermore, we studied functional CGRP release separately from the neuron soma and the part with only nerve fibers of the trigeminal ganglion, using an enzyme-linked immunosorbent assay. RESULTS: Antibodies towards CGRP and CLR/RAMP1 bind to two different ...
Muscle inflammation and hyperalgesia induced by adjuvant injection into skeletal muscle are associated with an increase in calcitonin gene-related peptide (CGRP) labeling in skeletal muscle and dorsal root ganglia (DRG). This increased expression of CGRP may contribute to the maintenance of pain in these models. However, it is not known if inflammation induced by repetitive exposure to stretch-sho
Depletion of substance P and calcitonin gene-related peptide in sciatic nerve of rats with experimental diabetes; effects of insulin and aldose reductase ...
BACKGROUND AND PURPOSE: A new concept for the inhibition of CGRP signalling has been developed by interaction with the CGRP molecule per se by using a CGRP antibody or a CGRP binding RNA-Spiegelmer (NOX-C89). We have compared these CGRP scavengers with two known receptor antagonists (CGRP8-37 and BIBN4096BS) on CGRP-induced relaxations in the rat middle cerebral artery (MCA). Furthermore, the role of the endothelial barrier has been studied. EXPERIMENTAL APPROACH: We used the luminally perfused MCA in an arteriograph, pressurized to 85 mm Hg and myograph studies of isolated ring segments of the MCA. KEY RESULTS: In myograph studies and in the perfusion system during abluminal application, alphaCGRP and betaCGRP induced concentration-dependent dilatation of the MCA. Given luminally neither peptide was significantly vasodilator. Adrenomedullin and amylin induced weak dilatations. In myograph experiments, relaxation induced by alphaCGRP was prevented by the four CGRP blockers (CGRP8-37, BIBN4096BS, ...
How is New Amyloid Component Protein abbreviated? NACP stands for New Amyloid Component Protein. NACP is defined as New Amyloid Component Protein very rarely.
ラット腰椎後縦靭帯における侵害受容神経と交感神経の関わりーCalcitonin gene-related peptide とtyrosine hydroxylase の免疫組織化学と免疫電顕による考察ー ...
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6 eV for MWCNTs (Ago et al. [24]; Su et al. [25])), A and B are constants with values of 1.56 × 10−6 (A·eV/V2) and 6.83 × 109 (V·eV−3/2 m−1), respectively, and β is the field enhancement factor that characterizes the ratio between the applied macroscopic. field and the local microscopic field felt by the apex of the emitter (Bonard et al. [26]). By fitting the data of Figure 2 to the FN expression, Figure 3 clearly shows that regardless of the AR value P505-15 clinical trial of the cathodes, two different domains can be distinguished in the FN plots, namely, high-field (HF) and low-field (LF) regimes. Accordingly, separate β HF and β LF enhancement factors were extracted from the slopes of the linear fits (Figure 3) and tabulated in the table at the bottom of Figure 3. First of all, in both HF and LF regimes, the enhancement factors are seen Quisinostat purchase to increase significantly (by a factor of 2.2 and 1.7 for β HF and β LF, respectively) as the AR is increased from 0 to ...
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Patient information for CALCITONIN 50 IU/ML SOLUTION FOR INJECTION AND INFUSION Including dosage instructions and possible side effects.
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Originally misidentified as an adrenomedullin receptor, recent observations have revealed that the orphan receptor GPR182 is expressed in stem cells in the crypt base of the gastrointestinal tract. This week in the JCI, work led by Kathleen Caron at the University of North Carolina has investigated the function of GPR182 in these crypt base stem cells, a population notable for high rates of proliferation. Although Gpr182 knockdown did not affect basal intestinal proliferation in mice, loss of Gpr182 was associated with increased proliferation following intestinal injury as well as increased tumor formation in a mouse model of intestinal adenoma. The researchers determined that loss of Gpr182 led to enhanced ERK1/2 activation, suggesting that GPR182 interacts with ERK signaling to regulate intestinal proliferation during regeneration and adenoma formation. These results identify GPR182 as a new potential target of therapies for gastrointestinal cancer.. The accompanying image shows a ...
Reactome is pathway database which provides intuitive bioinformatics tools for the visualisation, interpretation and analysis of pathway knowledge.
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Calcitonin gene-related peptide (CGRP), a sensory neurotransmitter that is widely distributed in cardiovascular tissues, may help to counteract coronary artery vasoconstriction during anaphylaxis. CGR... more
Calcitonin is a circulating polypeptide that inhibits bone resorption by inducing both quiescence (Q effect) and retraction (R effect) in osteoclasts. Two structurally related members of the calcitonin gene peptide family, calcitonin gene-related peptide (CGRP) and amylin, inhibit osteoclastic bone resorption selectively via the Q effect. In the present study, we have made measurements of cell spread area in response to the application of amylin, CGRP and a peptide fragment of CGRP, CGRP-(Val8Phe37). We found that, over a wide concentration range (50 pmol/l to 2.5 mumol/l), the selective Q effect agonists did not produce an R effect. Furthermore, the peptides, when used at a 50-fold higher molar concentration than calcitonin, did not antagonize calcitonin-induced cell retraction. Additionally, experiments designed to measure changes in the intracellular free calcium concentration ([Ca2+]i) in single osteoclasts revealed that, unlike calcitonin, the non-calcitonin Q effect agonists did not produce a rise
J Med Chem. 2008 Aug 28;51(16):4858-61. Epub 2008 Jul 30.Discovery of (R)-4-(8-fluoro-2-oxo-1,2-dihydroquinazolin-3(4H)-yl)-N-(3-(7-methyl-1H-indazol-5-yl)-1-oxo-1-(4-(piperidin-1-yl)piperidin-1-yl)propan-2-yl)piperidine-1-carboxamide (BMS-694153): a potent antagonist of the human calcitonin gene-related peptide receptor for migraine with rapid and efficient intranasal exposure. To Reference ...
Throughout my academic career, I have been focusing on the regulation of vascular tone in health and disease (diabetes type I and II, stroke, hypertension, congestive Heart Failure and age-related changes).. Coronary arteries are densely innervated by sensory nerve endings containing calcitonin gene-related peptide (CGRP). CGRP is a potent naturally occuring 37 amino acid vasodilatory neuropeptide which is released from the perivascular sensory nerve endings in the wall of flow regulating intramural coronary arteries during hypoxia and by low pH levels in the myocardium, thus suggesting a vasodilatory role under ischemic conditions.. Receptor subtypes for CGRP, the intracellular signalling pathways and the mechanism behind CGRP-induced desensitization are still under investigation in both resistance and conductance arteries of different species including human. So far, these studies clearly demonstrate a larger CGRP receptor density in resistance arteries (internal lumen diameter < 200 µm) ...
The fact that AM behaves as a local autocrine and/or paracrine hormone raises the possibility that AM released by CECs acts primarily on AM receptors present in the cerebral endothelium itself and on neighboring cells. The expression of CRLR, RAMP-1, -2, -3, was characterized on isolated rat cerebral microvessels [4], in rat CECs and cerebral pericytes [3], and in rat astrocytes [2]. In cultured rat CECs and peri-cytes RAMP-2 showed the highest expression, followed by RAMP-3 and RAMP-1, and exogenous AM increased the intracellular cAMP concentration suggesting the existence of functional AM receptors on these cells [3]. Although astrocyte-derived factors increased the AM production of rat CECs, they did not change the expression of AM receptor components in rat CECs. Oliver et al. [5] reported the same expression pattern of RAMPs in human cerebral vasculature.. Was this article helpful?. ...
IHCPlus™ CALCR / Calcitonin Receptor Antibody LS-A769 is a pathologist validated IHC antibody Rabbit anti-Human CALCR / Calcitonin Receptor. Validated for IHC. Tested on 20 paraffin-embedded human tissues.
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Zhang, Weiguo; Fraiture, Malou; Kolb, Dagmar; Loeffelhardt, Birgit; Desaki, Yoshitake; Boutrot, Freddy F. G.; Toer, Mahmut; Zipfel, Cyril; Gust, Andrea A.; Brunner, Frederic ...
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A receptor is defined by the International Union of Pharmacology Committee on Receptor Nomenclature and Drug Classification (NC-IUPHAR) as a protein, or a complex of proteins, which recognizes physiologically relevant ligands that can regulate the protein to mediate cellular events (Ruffolo et al., 2000). This definition does not include associated proteins, which are not required for agonist recognition and/or receptor assembly. Thus, G proteins are not included in the nomenclature of G protein-coupled receptors (GPCRs). Similarly, proteins which modify receptor disposition, such as proteins with a PDZ domain (Sheng and Sala, 2001), and which associate with the cytosolic portion of the receptor are not included. The question arises, however, as to the way to name multimeric receptors where subunits influence receptor assembly and agonist recognition. The essential issue is whether to name the individual proteins or the association of proteins? NC-IUPHAR recommends that, where possible, the ...
DI-fusion, le Dépôt institutionnel numérique de lULB, est loutil de référencementde la production scientifique de lULB.Linterface de recherche DI-fusion permet de consulter les publications des chercheurs de lULB et les thèses qui y ont été défendues.

Calcitonin receptor-like receptor activity modifying protein 3 | definition of calcitonin receptor-like receptor activity...Calcitonin receptor-like receptor activity modifying protein 3 | definition of calcitonin receptor-like receptor activity...

What is calcitonin receptor-like receptor activity modifying protein 3? Meaning of calcitonin receptor-like receptor activity ... What does calcitonin receptor-like receptor activity modifying protein 3 mean? ... calcitonin receptor-like receptor activity modifying protein 3 explanation free. ... Looking for online definition of calcitonin receptor-like receptor activity modifying protein 3 in the Medical Dictionary? ...
more infohttps://medical-dictionary.thefreedictionary.com/calcitonin+receptor-like+receptor+activity+modifying+protein+3

Effect of receptor activity-modifying protein-1 on vascular smooth muscle cellsEffect of receptor activity-modifying protein-1 on vascular smooth muscle cells

The receptors for CGRP include the calcitonin receptor-like receptor (CRLR), RAMP1, and the receptor component protein. RAMP1 ... Receptor activity-modifying protein 1 is the specificity receptors of calcitonin gene-related peptide. calcitonin gene-related ... exogenous receptor activity-modifying protein 1 enhances the antiproliferation effect of calcitonin gene-related peptide in ... Calcitonin gene related protein (CGRP) is one of the most well-known potent vasodilators and can regulate vascular tone and ...
more infohttps://medicalxpress.com/news/2014-03-effect-receptor-activity-modifying-protein-vascular.html

Expression of calcitonin receptor-like receptor in human vascular tumours | Journal of Clinical PathologyExpression of calcitonin receptor-like receptor in human vascular tumours | Journal of Clinical Pathology

Adrenomedullin, a potent vasodilative peptide, and its receptor, calcitonin receptor-like receptor (CRLR), play an important ... RAMP, receptor activity-modifying protein. *VEGF, vascular endothelial-derived growth factor. View Full Text ... CRLR, calcitonin receptor-like receptor. *CRLR-LI, calcitonin receptor-like receptor-like immunoreactivity ... CRLR, calcitonin receptor-like receptor. *CRLR-LI, calcitonin receptor-like receptor-like immunoreactivity ...
more infohttp://jcp.bmj.com/content/59/10/1104

Quantitative autoradiography reveals higher densities of specific calcitonin-gene-related peptide receptors in small...Quantitative autoradiography reveals higher densities of specific calcitonin-gene-related peptide receptors in small...

5 fmol/mg of protein). β-Human calcitonin-gene-related peptide showed higher affinity than α-human calcitonin-gene-related ... Quantitative autoradiography reveals higher densities of specific calcitonin-gene-related peptide receptors in small ... Quantitative autoradiography reveals higher densities of specific calcitonin-gene-related peptide receptors in small ... Quantitative autoradiography reveals higher densities of specific calcitonin-gene-related peptide receptors in small ...
more infohttp://www.clinsci.org/content/84/1/55

Calcitonin receptor Proteins, Recombinant | Sino BiologicalCalcitonin receptor Proteins, Recombinant | Sino Biological

... receptor recombinant proteins are produced in house and quality guaranteed.All the Calcitonin receptor recombinant proteins are ... Among these Calcitonin receptor proteins, there are 2 Human Calcitonin receptor protein. All these Calcitonin receptor protein ... 2 Calcitonin receptor proteins are expressed by HEK293 Cells . These Calcitonin receptor proteins are produced with different ... There are 2 Calcitonin receptor protein produced in house with high quality which are covering various species. ...
more infohttps://www.sinobiological.com/calcr-calcitonin-receptor-protein-mcalcr.html

SWISS-MODEL Template Library | 6niy.1SWISS-MODEL Template Library | 6niy.1

A high-resolution cryo-electron microscopy structure of a calcitonin receptor-heterotrimeric Gs protein complex ... Calcitonin receptor: C. Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1: D. Guanine nucleotide-binding protein ... A high-resolution cryo-electron microscopy structure of a calcitonin receptor-heterotrimeric Gs protein complex. Coordinates. ... dal Maso, E. et al., The Molecular Control of Calcitonin Receptor Signaling. Acs Pharmacol Transl Sci (2019) Release Date. 2019 ...
more infohttps://swissmodel.expasy.org/templates/6niy.1

Debbie Lucy Hay - WikipediaDebbie Lucy Hay - Wikipedia

Investigation of the calcitonin receptor-like receptor and receptor activity modifying proteins at Imperial College London. ... "Pharmacological discrimination of calcitonin receptor: receptor activity-modifying protein complexes." Molecular pharmacology ... "Regulation of signal transduction by calcitonin gene-related peptide receptors." Trends in pharmacological sciences 31, no. 10 ... "CL/RAMP2 and CL/RAMP3 produce pharmacologically distinct adrenomedullin receptors: a comparison of effects of adrenomedullin22- ...
more infohttps://en.wikipedia.org/wiki/Debbie_Lucy_Hay

More articles from ORIGINAL ARTICLE | Molecular PharmacologyMore articles from ORIGINAL ARTICLE | Molecular Pharmacology

Pharmacological Discrimination of Calcitonin Receptor: Receptor Activity-Modifying Protein Complexes Debbie L. Hay, George ... Concurrent Stimulation of Cannabinoid CB1 and Dopamine D2 Receptors Enhances Heterodimer Formation: A Mechanism for Receptor ... Potentiation of P2Y Receptors by Physiological Elevations of Extracellular K+ via a Mechanism Independent of Ca2+ Influx ... The Met852 Residue Is a Key Organizer of the Ligand-Binding Cavity of the Human Mineralocorticoid Receptor Jérôme Fagart, ...
more infohttp://molpharm.aspetjournals.org/content/by/section/ORIGINAL%20ARTICLE?page=3

Patrick Sexton - Research Output
     - Monash UniversityPatrick Sexton - Research Output - Monash University

Distinct receptor activity-modifying protein domains differentially modulate interaction with calcitonin receptors. Udawela, M ... Pharmacological discrimination of calcitonin receptor: receptor activity-modifying protein complexes. Hay, D. L., Christopoulos ... G-Protein-coupled receptor-protein interactions: basis for new concepts on receptor structure and function. Tilakaratne, N. & ... Receptor activity-modifying proteins differentially modulate the G protein-coupling efficiency of amylin receptors. Morfis, M ...
more infohttps://research.monash.edu/en/persons/patrick-sexton/publications/?type=%2Fdk%2Fatira%2Fpure%2Fresearchoutput%2Fresearchoutputtypes%2Fcontributiontojournal%2Farticle&page=3

Calcitonin Receptor - Semantic ScholarCalcitonin Receptor - Semantic Scholar

Calcitonin receptors outside the nervous system mediate the role of calcitonin in calcium homeostasis. The role of calcitonin ... Cell surface proteins that bind calcitonin and trigger intracellular changes which influence the behavior of cells. ... receptors in the brain is not well understood. ... a calcitonin receptor with receptor activity modifying proteins ... Calcitonin Receptor. Known as: Receptors, Calcitonin, Receptor, Calcitonin, Receptors, Calcitonin [Chemical/Ingredient] (More) ...
more infohttps://www.semanticscholar.org/topic/Calcitonin-Receptor/1355847

Calcitonin receptor - WikipediaCalcitonin receptor - Wikipedia

The calcitonin receptor (CT) is a G protein-coupled receptor that binds the peptide hormone calcitonin and is involved in ... "Multiple amylin receptors arise from receptor activity-modifying protein interaction with the calcitonin receptor gene product ... The function of the CT receptor protein is modified through its interaction with Receptor activity-modifying proteins (RAMPs), ... "Calcitonin Receptors: Introduction". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical ...
more infohttps://en.wikipedia.org/wiki/Calcitonin_receptor

Integrative Structural Biology | Thermo Fisher ScientificIntegrative Structural Biology | Thermo Fisher Scientific

... it is essential that researchers determine protein complex assembly and structure beyond that of individual proteins. Solving ... To understand protein functioning in the cellular environment, ... structure of a calcitonin receptor-heterotrimeric Gs protein ... Proteins of the 28S subunit. CX-MS crosslinks used to identify mitochondrial-specific ribosomal proteins or confirm their ... Native MS tells you if the intact complex matches the mass of the protein subunits, if the complete protein might exist in ...
more infohttps://www.fei.com/integrative-structural-biology/

Single Particle Analysis Workflow, The Challenges of Protein Complex Analysis | Thermo Fisher ScientificSingle Particle Analysis Workflow, The Challenges of Protein Complex Analysis | Thermo Fisher Scientific

Although large protein complexes provide more insight to native function, it has been difficult to stabilize and crystallize ... Besides the fact that crystallization is a time-consuming process - which may not always be successful as some proteins do not ... scientists have had to engineer and crystalize proteins in order to reconstruct and visualize them via X-ray crystallography. ... Volta phase plate cryo-electron microscopy structure of a calcitonin receptor-heterotrimeric Gs protein complex ...
more infohttps://fei.com/life-sciences/single-particle-analysis-workflow/

The History of Cryo-Electron Microscopy | Thermo Fisher ScientificThe History of Cryo-Electron Microscopy | Thermo Fisher Scientific

Volta phase plate cryo-electron microscopy structure of a calcitonin receptor-heterotrimeric Gs protein complex ... Researchers have used cryo-EM to determine the ternary complex structure of the calcitonin receptor for a class B G protein- ... Using Cryo-EM to understand molecular structures such as proteins, protein complexes, and protein-ribonucleic acid associations ... coupled receptor (GPCR), an important membrane protein complex that has been difficult to analyze by other means. Nature, June ...
more infohttps://www.fei.com/cryo-em/

Single Particle Analysis Workflow, The Challenges of Protein Complex Analysis | Thermo Fisher ScientificSingle Particle Analysis Workflow, The Challenges of Protein Complex Analysis | Thermo Fisher Scientific

Although large protein complexes provide more insight to native function, it has been difficult to stabilize and crystallize ... Besides the fact that crystallization is a time-consuming process - which may not always be successful as some proteins do not ... scientists have had to engineer and crystalize proteins in order to reconstruct and visualize them via X-ray crystallography. ... Volta phase plate cryo-electron microscopy structure of a calcitonin receptor-heterotrimeric Gs protein complex ...
more infohttps://fei.com/life-sciences/single-particle-analysis/

Stephen Ward
     - the University of Baths research portalStephen Ward - the University of Bath's research portal

Once again, we are using fluorescently-tagged proteins (e.g. receptors and signaling proteins such as PI3K and RabGTPAses) to ... of the Molecular Mechanisms Regulating the Signalling and Post-endocytic sorting of the Receptors for Calcitonin Gene-Related ... stimulation of the T cell antigen receptor. This is acheived by using fluorescently-tagged (e.g. green fluorescent protein) ... Protein Glycation Biomarkers for Alzheimers Disease. Van Den Elsen, J., James, T., Ward, S. & Williams, R. ...
more infohttps://researchportal.bath.ac.uk/en/persons/stephen-ward/

Publications - Mayo ClinicPublications - Mayo Clinic

Receptor activity-modifying protein-dependent impairment of calcitonin receptor splice variant Delta(1-47)hCT((a)) function. Br ... Molecular basis of association of receptor activity-modifying protein 3 with the family B G protein-coupled secretin receptor. ... Juxtamembranous region of the amino terminus of the family B G protein-coupled calcitonin receptor plays a critical role in ... the amino-terminal region of calcitonin and the third extracellular loop of the class B G protein-coupled calcitonin receptor. ...
more infohttp://www.mayo.edu/research/searchpublications/publications?authid=10223401

MEDLINE - Resultado p gina 1
	MEDLINE - Resultado p gina 1

Calcitonin Receptor-Like Protein); 0 (Calcrl protein, rat); 0 (Ramp1 protein, rat); 0 (Receptor Activity-Modifying Protein 1); ... Receptor activity-modifying protein 1 (RAMP1) forms a complex with calcitonin receptor-like receptor to generate the receptor ... CGRP receptor is composed of receptor activity-modifying protein (RAMP) 1 combined with calcitonin receptor-like receptor (CRLR ... a single TMD protein required by several seven-TMD G-protein-coupled receptors including the calcitonin receptor-like receptor ...
more infohttp://bases.bireme.br/cgi-bin/wxislind.exe/iah/online/?IsisScript=iah/iah.xis&nextAction=lnk&base=MEDLINE&lang=p&format=detailed.pft&indexSearch=EX&exprSearch=D12.776.476.024.414.100

PTK2 - WikipediaPTK2 - Wikipedia

... family member HEF1 downstream of the G protein-coupled calcitonin receptor. Calcitonin induces the association of HEF1, ... MeSH protein, human PTK2 protein, human. *"Breaking down cancers wall of resistance", by DR Nick Peel, Cancer Research UK, ... PTK2 proteinska tirozinska kinaza 2 (PTK2, Fokalna adheziona kinaza, FAK), protein je koji je kod ljudi kodiran PTK2 genom.[2] ... "The GIT family of proteins forms multimers and associates with the presynaptic cytomatrix protein Piccolo". J. Biol. Chem. 278 ...
more infohttps://sh.wikipedia.org/wiki/PTK2

Calcitonin Gene-Related Peptide Is an Important Regulator of Cutaneous Immunity: Effect on Dendritic Cell and T Cell Functions ...Calcitonin Gene-Related Peptide Is an Important Regulator of Cutaneous Immunity: Effect on Dendritic Cell and T Cell Functions ...

CGRP binds to its receptors composed of receptor activity-modifying protein 1 and calcitonin receptor-like receptor to modulate ... CGRP binds to its specific receptor composed of receptor activity-modifying protein 1 (RAMP1) and calcitonin receptor-like ... calcitonin gene-related peptide. CHS. contact hypersensitivity. CLR. calcitonin receptor-like receptor. DC. dendritic cell. dDC ... RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor. Nature 393: 333-339. ...
more infohttp://www.jimmunol.org/content/186/12/6886

Expression of calcitonin receptors in mouse preimplantation embryos and their function in the regulation of blastocyst...Expression of calcitonin receptors in mouse preimplantation embryos and their function in the regulation of blastocyst...

The binding of calcitonin to a G protein-coupled receptor activates adenylate cyclase and elevates cytosolic Ca2+ levels. The ... Expression of calcitonin receptors in mouse preimplantation embryos and their function in the regulation of blastocyst ... Expression of calcitonin receptors in mouse preimplantation embryos and their function in the regulation of blastocyst ... Expression of calcitonin receptors in mouse preimplantation embryos and their function in the regulation of blastocyst ...
more infohttp://dev.biologists.org/content/125/21/4293

Interaction ExplorerInteraction Explorer

receptor (calcitonin) activity modifying protein 3. protein coding gene. Filter interactions by: Interaction Validation Data ... Additional interaction types (e.g., protein-protein, genetic, co-expression) are currently not represented but will be ...
more infohttp://www.informatics.jax.org/interaction/explorer?markerIDs=MGI:1860292

Browse our Calcitonin Receptor ELISA KitsBrowse our Calcitonin Receptor ELISA Kits

Compare Calcitonin Receptor ELISA Kits and find the right product on antibodies-online.com. ... Order Calcitonin Receptor ELISA Kits for many Reactivities. Chicken, Guinea Pig, Human and more. ... Protein level used designations for Calcitonin Receptor (CALCR) ELISA Kits calcitonin receptor , CTR , calcitonin receptor-like ... and Calcitonin Receptor Proteins (11) and many more products for this protein. A total of 180 Calcitonin Receptor products are ...
more infohttp://www.antibodies-online.com/camp-metabolic-process-pathway-59/calcitonin-receptor-elisa-kit-596/

CALCB - Calcitonin gene-related peptide 2 precursor - Homo sapiens (Human) - CALCB gene & proteinCALCB - Calcitonin gene-related peptide 2 precursor - Homo sapiens (Human) - CALCB gene & protein

calcitonin receptor binding Source: GO_Central ,p>Inferred from Biological aspect of Ancestor,/p> ,p>A type of phylogenetic ... View protein in InterPro. IPR021117 Calcitonin-like. IPR021116 Calcitonin/adrenomedullin. IPR018360 Calcitonin_CS. IPR015476 ... View protein in InterPro. IPR021117 Calcitonin-like. IPR021116 Calcitonin/adrenomedullin. IPR018360 Calcitonin_CS. IPR015476 ... to allow unambiguous identification of a protein.,p>,a href=/help/protein_names target=_top>More...,/a>,/p>Protein namesi. ...
more infohttps://www.uniprot.org/uniprot/P10092

ACTH protects against glucocorticoid-induced osteonecrosis of bone | PNASACTH protects against glucocorticoid-induced osteonecrosis of bone | PNAS

G) qPCR for late differentiation markers, such as integrin β3 and the calcitonin receptor (CTR), and control proteins, such as ... 4F). However, the relatively late-onset genes, including the calcitonin receptor and integrin β3, failed to rise with ACTH as ... including those downstream of G protein coupled receptors (16). ... However, the expression of the ACTH receptor MC2R was ... All were negative, with p values from 0.3 to 0.9 (not shown). The lack of receptors for ACTH on mature osteoclasts makes an ...
more infohttps://www.pnas.org/content/107/19/8782
  • Glucagon-like peptide-1 receptor dimerization differentially regulates agonist signaling but does not affect small molecule allostery. (nih.gov)
  • Site of action of a pentapeptide agonist at the glucagon-like peptide-1 receptor. (nih.gov)
  • Coexpressed Class B G Protein-Coupled Secretin and GLP-1 Receptors Self- and Cross-Associate: Impact on Pancreatic Islets. (mayo.edu)
  • Ward RJ, Pediani JD, Harikumar KG, Miller LJ , Milligan G. Spatial intensity distribution analysis quantifies the extent and regulation of homodimerization of the secretin receptor. (mayo.edu)
  • Insights into the impact of phenolic residue incorporation at each position along secretin for receptor binding and biological activity. (nih.gov)
  • Mapping spatial approximations between the amino terminus of secretin and each of the extracellular loops of its receptor using cysteine trapping. (nih.gov)
  • Importance of each residue within secretin for receptor binding and biological activity. (nih.gov)
  • Elucidation of the active conformation of the amino terminus of receptor-bound secretin using intramolecular disulfide bond constraints. (nih.gov)
  • Cryo-Electron Microscopy (Cryo-EM) begins with vitrification, in which the protein solution is cooled so rapidly that water molecules do not have time to crystallize, forming an amorphous solid that does little or no damage to the sample structure (a process known as vitrification). (fei.com)
  • Beneficial effects of beta-sitosterol on type 1 cholecystokinin receptor dysfunction induced by elevated membrane cholesterol. (mayo.edu)
  • Metabolic Actions of the Type 1 Cholecystokinin Receptor: Its Potential as a Therapeutic Target. (mayo.edu)
  • RESULTS: Compared with that in WT mice, lymphedema in the tails in RAMP1-/- mice was sustained, with suppressed lymphangiogenesis and reduced expression of vascular endothelial growth factor-C and vascular endothelial growth factor receptor 3 at the distal edge of the lesions. (bireme.br)
  • Calcitonin secretion in the pregnant uterus is tightly regulated by the ovarian hormones, estrogen and progesterone, which limit its expression to a brief period preceding blastocyst implantation. (biologists.org)
  • These findings support the concept that calcitonin secretion within the progesterone-primed uterus and the coordinate expression of CR-1a by preimplantation embryos regulates blastocyst differentiation through receptor-mediated Ca2+ signaling. (biologists.org)
  • Additional interaction types (e.g., protein-protein, genetic, co-expression) are currently not represented but will be implemented over time. (jax.org)
  • 1992). "Cloning, characterization, and expression of a human calcitonin receptor from an ovarian carcinoma cell line" . (wikipedia.org)
  • These findings are associated with a reduced gene expression of osteoprotegerin, sclerostin, calcitonin receptor (CTR), insulin-like growth factor binding protein 5 and RUNX2. (biomedcentral.com)
  • Low doses of IGF-I constituted a real replacement therapy that normalized IGF-I serum levels improving the expression of most of these proteins closely involved in bone-forming, and reducing bone resorption by mechanisms related to osteoprotegerin, RANKL and PTH receptor. (biomedcentral.com)
  • p>When browsing through different UniProt proteins, you can use the 'basket' to save them, so that you can back to find or analyse them later. (uniprot.org)
  • p>This section provides any useful information about the protein, mostly biological knowledge. (uniprot.org)
  • Wootten D, Miller LJ , Koole C, Christopoulos A, Sexton PM. Allostery and Biased Agonism at Class B G Protein-Coupled Receptors. (mayo.edu)
  • Chemical crosslinking followed by MS provides information on the global protein subunit topology within a large complex. (fei.com)
  • Proteins of the 28S subunit. (fei.com)
  • Changes in the plasma membrane in metabolic disease: impact of the membrane environment on G protein-coupled receptor structure and function. (mayo.edu)
  • The principle aim of my work is to visualise the spatio-temporal organisation of the major PI3K lipid products PI(3)P, PI(3,4)P2 and PI(3,4,5)P3 in T lymphocytes undergoing two distinct types of polarised response: (i) directional migration towards chemokines and (ii) stimulation of the T cell antigen receptor. (bath.ac.uk)
  • ATM is a key trigger protein in the DNA damage response and a prime therapeutic target in cancer research. (fei.com)