AnatomyDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesInformation Science
Calcitonin Gene-Related PeptideCalcitoninBethanechol CompoundsBethanecholSubstance PNeuropeptide YNeuropeptidesCapsaicinNerve FibersVasoactive Intestinal PeptidePeptidesReceptors, CalcitoninReceptors, Calcitonin Gene-Related PeptideThyroid NeoplasmsPeptide FragmentsRNA, MessengerCalcitonin Receptor-Like ProteinFMRFamideBase SequenceAmino Acid SequenceGenesBlotting, SouthernOligopeptidesMolecular Sequence DataCarnosinePeptide LibraryParathyroid Hormone-Related ProteinPeptide PHITranscription, GeneticBombesinReceptors, CholinergicPubMedPeriodicals as TopicMyasthenia GravisMethylergonovineAnaphylaxisReceptor Activity-Modifying ProteinsSterilization, TubalMigraine DisordersEthinyl EstradiolIntrauterine DevicesLevonorgestrelInsulinGlucoseIslet Amyloid PolypeptideBlood GlucoseInsulin ResistanceCluster HeadacheHeadacheHeadache Disorders, PrimaryMeningesNociceptorsTrigeminal Ganglion
Calcitonin Gene-Related Peptide
Calcitonin gene-related peptide. A 37-amino acid peptide derived from the calcitonin gene. It occurs as a result of alternative processing of mRNA from the calcitonin gene. The neuropeptide is widely distributed in neural tissue of the brain, gut, perivascular nerves, and other tissue. The peptide produces multiple biological effects and has both circulatory and neurotransmitter modes of action. In particular, it is a potent endogenous vasodilator.
Calcitonin
A peptide hormone that lowers calcium concentration in the blood. In humans, it is released by thyroid cells and acts to decrease the formation and absorptive activity of osteoclasts. Its role in regulating plasma calcium is much greater in children and in certain diseases than in normal adults.
Bethanechol Compounds
Bethanechol
A slowly hydrolyzing muscarinic agonist with no nicotinic effects. Bethanechol is generally used to increase smooth muscle tone, as in the GI tract following abdominal surgery or in urinary retention in the absence of obstruction. It may cause hypotension, HEART RATE changes, and BRONCHIAL SPASM.
Substance P
An eleven-amino acid neurotransmitter that appears in both the central and peripheral nervous systems. It is involved in transmission of PAIN, causes rapid contractions of the gastrointestinal smooth muscle, and modulates inflammatory and immune responses.
Neuropeptide Y
A 36-amino acid peptide present in many organs and in many sympathetic noradrenergic neurons. It has vasoconstrictor and natriuretic activity and regulates local blood flow, glandular secretion, and smooth muscle activity. The peptide also stimulates feeding and drinking behavior and influences secretion of pituitary hormones.
Neuropeptides
Peptides released by NEURONS as intercellular messengers. Many neuropeptides are also hormones released by non-neuronal cells.
Capsaicin
An alkylamide found in CAPSICUM that acts at TRPV CATION CHANNELS.
Nerve Fibers
Slender processes of NEURONS, including the AXONS and their glial envelopes (MYELIN SHEATH). Nerve fibers conduct nerve impulses to and from the CENTRAL NERVOUS SYSTEM.
Vasoactive Intestinal Peptide
A highly basic, 28 amino acid neuropeptide released from intestinal mucosa. It has a wide range of biological actions affecting the cardiovascular, gastrointestinal, and respiratory systems and is neuroprotective. It binds special receptors (RECEPTORS, VASOACTIVE INTESTINAL PEPTIDE).
Peptides
Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.
Receptors, Calcitonin
Cell surface proteins that bind calcitonin and trigger intracellular changes which influence the behavior of cells. Calcitonin receptors outside the nervous system mediate the role of calcitonin in calcium homeostasis. The role of calcitonin receptors in the brain is not well understood.
Receptors, Calcitonin Gene-Related Peptide
Cell surface proteins that bind CALCITONIN GENE-RELATED PEPTIDE with high affinity and trigger intracellular changes which influence the behavior of cells. CGRP receptors are present in both the CENTRAL NERVOUS SYSTEM and the periphery. They are formed via the heterodimerization of the CALCITONIN RECEPTOR-LIKE PROTEIN and RECEPTOR ACTIVITY-MODIFYING PROTEIN 1.
Thyroid Neoplasms
Tumors or cancer of the THYROID GLAND.
Peptide Fragments
Partial proteins formed by partial hydrolysis of complete proteins or generated through PROTEIN ENGINEERING techniques.
RNA, Messenger
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Calcitonin Receptor-Like Protein
A receptor protein that is associated with RECEPTOR ACTIVITY-MODIFYING PROTEINS. When bound to RECEPTOR ACTIVITY-MODIFYING PROTEIN 1 it forms the CALCITONIN GENE-RELATED RECEPTOR. When bound to RECEPTOR ACTIVITY-MODIFYING PROTEIN 2 or RECEPTOR ACTIVITY-MODIFYING PROTEIN 3 it forms the ADRENOMEDULLIN RECEPTOR.
FMRFamide
A molluscan neuroactive peptide which induces a fast excitatory depolarizing response due to direct activation of amiloride-sensitive SODIUM CHANNELS. (From Nature 1995; 378(6558): 730-3)
Base Sequence
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
Amino Acid Sequence
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
Genes
A category of nucleic acid sequences that function as units of heredity and which code for the basic instructions for the development, reproduction, and maintenance of organisms.
Blotting, Southern
A method (first developed by E.M. Southern) for detection of DNA that has been electrophoretically separated and immobilized by blotting on nitrocellulose or other type of paper or nylon membrane followed by hybridization with labeled NUCLEIC ACID PROBES.
Oligopeptides
Peptides composed of between two and twelve amino acids.
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Carnosine
A naturally occurring dipeptide neuropeptide found in muscles.
Peptide Library
A collection of cloned peptides, or chemically synthesized peptides, frequently consisting of all possible combinations of amino acids making up an n-amino acid peptide.
Parathyroid Hormone-Related Protein
A ubiquitously expressed, secreted protein with bone resorption and renal calcium reabsorption activities that are similar to PARATHYROID HORMONE. It does not circulate in appreciable amounts in normal subjects, but rather exerts its biological actions locally. Overexpression of parathyroid hormone-related protein by tumor cells results in humoral calcemia of malignancy.
Peptide PHI
A 27-amino acid peptide with histidine at the N-terminal and isoleucine amide at the C-terminal. The exact amino acid composition of the peptide is species dependent. The peptide is secreted in the intestine, but is found in the nervous system, many organs, and in the majority of peripheral tissues. It has a wide range of biological actions, affecting the cardiovascular, gastrointestinal, respiratory, and central nervous systems.
Transcription, Genetic
The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.
Bombesin
A tetradecapeptide originally obtained from the skins of toads Bombina bombina and B. variegata. It is also an endogenous neurotransmitter in many animals including mammals. Bombesin affects vascular and other smooth muscle, gastric secretion, and renal circulation and function.
Receptors, Cholinergic
Cell surface proteins that bind acetylcholine with high affinity and trigger intracellular changes influencing the behavior of cells. Cholinergic receptors are divided into two major classes, muscarinic and nicotinic, based originally on their affinity for nicotine and muscarine. Each group is further subdivided based on pharmacology, location, mode of action, and/or molecular biology.
PubMed
A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.
Periodicals as Topic
A publication issued at stated, more or less regular, intervals.
Myasthenia Gravis
A disorder of neuromuscular transmission characterized by weakness of cranial and skeletal muscles. Autoantibodies directed against acetylcholine receptors damage the motor endplate portion of the NEUROMUSCULAR JUNCTION, impairing the transmission of impulses to skeletal muscles. Clinical manifestations may include diplopia, ptosis, and weakness of facial, bulbar, respiratory, and proximal limb muscles. The disease may remain limited to the ocular muscles. THYMOMA is commonly associated with this condition. (Adams et al., Principles of Neurology, 6th ed, p1459)
Methylergonovine
A homolog of ERGONOVINE containing one more CH2 group. (Merck Index, 11th ed)
Anaphylaxis
An acute hypersensitivity reaction due to exposure to a previously encountered ANTIGEN. The reaction may include rapidly progressing URTICARIA, respiratory distress, vascular collapse, systemic SHOCK, and death.
Receptor Activity-Modifying Proteins
A family of proteins that bind to CELL SURFACE RECEPTORS and alter their specificity, signaling mechanism, or mode of intracellular transport.
Sterilization, Tubal
Procedures that render the female sterile by interrupting the flow in the FALLOPIAN TUBE. These procedures generally are surgical, and may also use chemicals or physical means.
Migraine Disorders
A class of disabling primary headache disorders, characterized by recurrent unilateral pulsatile headaches. The two major subtypes are common migraine (without aura) and classic migraine (with aura or neurological symptoms). (International Classification of Headache Disorders, 2nd ed. Cephalalgia 2004: suppl 1)
Ethinyl Estradiol
A semisynthetic alkylated ESTRADIOL with a 17-alpha-ethinyl substitution. It has high estrogenic potency when administered orally, and is often used as the estrogenic component in ORAL CONTRACEPTIVES.
Intrauterine Devices
Contraceptive devices placed high in the uterine fundus.
Levonorgestrel
A synthetic progestational hormone with actions similar to those of PROGESTERONE and about twice as potent as its racemic or (+-)-isomer (NORGESTREL). It is used for contraception, control of menstrual disorders, and treatment of endometriosis.
Insulin
A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1).
Glucose
A primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. It is used therapeutically in fluid and nutrient replacement.
Islet Amyloid Polypeptide
A pancreatic beta-cell hormone that is co-secreted with INSULIN. It displays an anorectic effect on nutrient metabolism by inhibiting gastric acid secretion, gastric emptying and postprandial GLUCAGON secretion. Islet amyloid polypeptide can fold into AMYLOID FIBRILS that have been found as a major constituent of pancreatic AMYLOID DEPOSITS.
Blood Glucose
Glucose in blood.
Insulin Resistance
Diminished effectiveness of INSULIN in lowering blood sugar levels: requiring the use of 200 units or more of insulin per day to prevent HYPERGLYCEMIA or KETOSIS.
Cluster Headache
A primary headache disorder that is characterized by severe, strictly unilateral PAIN which is orbital, supraorbital, temporal or in any combination of these sites, lasting 15-180 min. occurring 1 to 8 times a day. The attacks are associated with one or more of the following, all of which are ipsilateral: conjunctival injection, lacrimation, nasal congestion, rhinorrhea, facial SWEATING, eyelid EDEMA, and miosis. (International Classification of Headache Disorders, 2nd ed. Cephalalgia 2004: suppl 1)
Headache
The symptom of PAIN in the cranial region. It may be an isolated benign occurrence or manifestation of a wide variety of HEADACHE DISORDERS.
Headache Disorders, Primary
Conditions in which the primary symptom is HEADACHE and the headache cannot be attributed to any known causes.
Meninges
The three membranes that cover the BRAIN and the SPINAL CORD. They are the dura mater, the arachnoid, and the pia mater.
Nociceptors
Peripheral AFFERENT NEURONS which are sensitive to injuries or pain, usually caused by extreme thermal exposures, mechanical forces, or other noxious stimuli. Their cell bodies reside in the DORSAL ROOT GANGLIA. Their peripheral terminals (NERVE ENDINGS) innervate target tissues and transduce noxious stimuli via axons to the CENTRAL NERVOUS SYSTEM.
Trigeminal Ganglion
The semilunar-shaped ganglion containing the cells of origin of most of the sensory fibers of the trigeminal nerve. It is situated within the dural cleft on the cerebral surface of the petrous portion of the temporal bone and gives off the ophthalmic, maxillary, and part of the mandibular nerves.

Calcitonin gene-related peptide decreases expression of acetylcholinesterase in mammalian myotubes. (1/1567)

Nerve-derived trophic factors are known to modulate expression of acetylcholinesterase (AChE) in skeletal muscle fibers, yet the precise identity of these factors remains elusive. In the present study, we treated mouse C2 myotubes with calcitonin gene-related peptide (CGRP). Compared to non-treated myotubes, cell-associated AChE activity levels were decreased by approximately 60% after 48 h of treatment. A parallel reduction in AChE total protein levels was also observed as determined by Western blot analysis. The reduction in AChE activity was due to a decrease in the levels of the G1 molecular form and to an elimination of G1. By contrast, levels of secreted AChE remained unchanged following CGRP treatment. Finally, the overall decrease in AChE activity was accompanied by a reduction in AChE transcripts which could not be attributed to changes in the transcriptional rate of the ACHE gene.  (+info)

Interaction of amylin with calcitonin gene-related peptide receptors in the microvasculature of the hamster cheek pouch in vivo. (2/1567)

1. This study used intravital microscopy to investigate the receptors stimulated by amylin which shares around 50% sequence homology with the vasodilator calcitonin gene-related peptide (CGRP) in the hamster cheek pouch microvasculature in vivo. 2. Receptor agonists dilated arterioles (diameters 20-40 microm). The -log of the concentrations (+/- s.e.mean; n = 8) causing 50% increase in arteriole diameter were: human betaCGRP (10.8 +/- 0.3), human alphaCGRP (10.8 +/- 0.4), rat alphaCGRP (10.4 +/- 0.3). Rat amylin and the CGRP2 receptor selective agonist [Cys(ACM2,7]-human alphaCGRP were 100 fold less potent (estimates were 8.5 +/- 0.4 and 8.2 +/- 0.3 respectively). 3. The GCRP1 receptor antagonist, CGRP8-37 (300 nmol kg(-1); i.v.) reversibly inhibited the increase in diameter evoked by human alphaCGRP (0.3 nM) from 178 +/- 22% to 59 +/- 12% (n = 8; P < 0.05) and by rat amylin (100 nM) from 138 +/- 23% to 68 +/- 24% (n = 6; P < 0.05). CGRP8-37 did not inhibit vasodilation evoked by substance P (10 nM; n = 4: P > 0.05). 4. The amylin receptor antagonist, amylin8-37 (300 nmol kg(-1); i.v.) did not significantly inhibit the increase in diameter evoked by human alphaCGRP (0.3 nM) which was 112 +/- 26% in the absence, and 90 +/- 29% in the presence of antagonist (n = 4; P < 0.05); nor that evoked by rat amylin (100 nM) which was 146 +/- 23% in the absence and 144 +/- 32% in the presence of antagonist (n = 4; P > 0.05). 5. The agonist profile for vasodilatation and the inhibition of this dilatation by CGRP8-37, although not the amylin8-37 indicates that amylin causes vasodilatation through interaction with CGRP1 receptors in the hamster cheek pouch.  (+info)

Neurogenic origin of articular hyperemia in early degenerative joint disease. (3/1567)

It has been speculated that joint instability resulting from anterior cruciate ligament (ACL) rupture could be exacerbated by changes in vasomotor activity in the remaining supporting structures. In this study, the effect of ACL transection on medial collateral ligament (MCL) basal perfusion and its responsiveness to calcitonin gene-related peptide (CGRP) and sympathetic adrenergic influences was examined. Using urethan-anesthetized rabbits, we tested the effects of CGRP and its antagonist CGRP-(8-37) by topical application of these agents to the exposed knee while sympathetic influences were tested by electrically stimulating the saphenous nerve. It was found that MCL basal perfusion was elevated in ACL-sectioned joints; however, this effect was abrogated by prior resection of the articular nerve supply. At the doses tested, the normal vasodilator response to CGRP was abolished in ACL-sectioned joints, whereas the response to CGRP-(8-37) was attenuated. Even under the influence of increased constrictor tone, MCL and capsule blood vessels still showed substantially reduced responses to exogenous CGRP administration. By contrast, nerve-mediated constrictor responses were mostly unaffected by joint instability. This study suggests that posttraumatic knee joint hyperemia is neurogenically mediated, possibly by increased secretion of CGRP.  (+info)

Attenuation of myocardial injury due to oxygen free radicals (OFR) by pretreatment with OFR or calcitonin gene-related peptide. (4/1567)

AIM: To study the cardioprotective effects of oxygen free radicals (OFR) and calcitonin gene-related peptide (OGRP) pretreatment on myocardial damages due to OFR in isolated perfused rat heart. METHODS: The hearts were perfused in a Langendorff mode. OFR were generated by electrolysis of Krebs-Henseleit (K-H) solution. RESULTS: OFR pretreatment reduced the impairment of cardiac contractile function, the decrease of coronary flow and the increase of creatinine kinase (CK) release due to OFR, and the effect exhibited period dependence and cycle-dependence. 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine (H-7), an inhibitor of protein kinase C, abolished the protection of OFR pretreatment (CK release = 110 +/- 7, 215 +/- 23, 169 +/- 14, 240 +/- 30, and 113 +/- 19 kU.L-1 for control, OFR, OFR pretreatment, OFR pretreatment plus H-7, and H-7, respectively). CGRP pretreatment also protected the myocardium damages elicited by OFR in isolated perfused rat heart. CONCLUSIONS: OFR or CGRP pretreatment protected myocardium against injury elicited by OFR, and the effect of OFR pretreatment was related to the activation of PKC.  (+info)

Trigeminal nerve ganglion stimulation-induced neurovascular reflexes in the anaesthetized cat: role of endothelin(B) receptors in carotid vasodilatation. (5/1567)

1. The effects of intravenous administration of endothelin (ET) receptor antagonists SB-209670 (0.001-10.0 mg kg(-1)), SB-217242, SB-234551 (0.01-10.0 mg kg(-1)) and BQ-788 (0.001-1.0 mg kg(-1)) were investigated on trigeminal nerve ganglion stimulation-induced neurovascular reflexes in the carotid vasculature of the anaesthetized cat. Comparisons were made with sumatriptan (0.003-3.0 mg kg(-1)) and alpha-CGRP8-37 (0.001-0.1 mg kg(-1)). 2. Trigeminal nerve ganglion stimulation produced frequency related increases in carotid blood flow, reductions in carotid vascular resistance and non-frequency related increases in blood pressure. Guanethidine (3 mg kg(-1), i.v.) blocked trigeminal nerve ganglion-induced increases in blood pressure but had no effect on changes in carotid flow or resistance. Maximal reductions in carotid vascular resistance was observed at 10 Hz, and this frequency was selected to investigate the effects of drugs on trigeminal nerve ganglion stimulation-induced responses in guanethidine treated cats. 3. Saline, alpha-CGRP8-37 SB-209670 and BQ-788 had little or no effect on resting haemodynamic parameters. SB-217242 (10 mg kg(-1), n=3) produced a 56% reduction in arterial blood pressure whereas SB-233451 (10 mg kg(-1), n=3) produced a 30% reduction in carotid vascular resistance. Sumatriptan produced dose-related reductions in resting carotid flow and increases (max. 104% at 0.3 mg kg(-1), n = 5) in vascular resistance. 4. SB-209670 (n=6-7), SB-217242 (n=3) and BQ-788 (n=3) produced inhibition of trigeminal nerve ganglion stimulation-induced reductions in carotid vascular resistance. Saline, SB-234551, alpha-CGRP8-37 and sumatriptan had no effect. 5. These data demonstrate ET(B) receptor blockade attenuates the vasodilator effects of trigeminal nerve ganglion stimulation in the carotid vascular bed of guanethidine pretreated anaesthetized cats.  (+info)

Depletion of cutaneous peptidergic innervation in HIV-associated xerosis. (6/1567)

Severe xerosis occurs in approximately 20% of human immunodeficiency virus seropositive patients. Changes in cutaneous innervation have been found in various inflammatory skin diseases and in xerotic skin in familial amyloid. We have therefore carried out a quantitative examination of the cutaneous peptidergic innervation in human immunodeficiency virus-associated xerosis. Immunohistochemistry and image analysis quantitation were used to compare total cutaneous innervation (protein gene product 9.5), calcitonin gene-related peptide, substance P, and vasoactive intestinal peptide peptidergic fibers, at two sites in the skin of human immunodeficiency virus-associated xerosis patients (upper arm, n = 12; upper leg, n = 11) and site-matched seronegative controls (upper arm, n = 10; upper leg, n = 10). Measurement of lengths of fibers of each type was carried out for each subject in the epidermis and papillary dermis, and around the sweat glands. Immunostained mast cells in these areas were counted. Epidermal integrity and maturation were assessed by immunostaining for involucrin. There were significant (Mann-Whitney U test; p < 0.02) decreases in total lengths of protein gene product 9.5 fibers in both epidermis/papillary dermis and sweat gland fields; of calcitonin gene-related peptide innervation in the epidermis/papillary dermis; and of substance P innervation of the sweat glands. There were no differences in the distribution of mast cells, or in the epidermal expression of involucrin. Depletion of the calcitonin gene-related peptide innervation may affect the nutrient blood supply of the upper dermis, and the integrity and function of basal epidermis and Langerhans cells. Diminished substance P innervation of the sweat glands may affect their secretory activity. Both of these changes may be implicated in the development of xerosis.  (+info)

Decreased CGRP, but preserved Trk A immunoreactivity in nerve fibres in inflamed human superficial temporal arteries. (7/1567)

The peptidergic sensory innervation of cranial blood vessels may play an important part in vascular head pain. The neuropeptides calcitonin gene-related peptide (CGRP) and substance P in sensory fibres are dependent on nerve growth factor (NGF) produced by the blood vessels, and when released from nerve terminals mediate neurogenic inflammation. NGF is increased in inflamed tissues, and acts via its high affinity receptor trk A on nociceptor fibres to produce hyperalgesia. CGRP and trk A immunoreactive nerve fibres have therefore been studied, for the first time, in inflamed (n=7) and non-inflamed (n=10) temporal arteries biopsied from patients with headache and suspected giant cell arteritis. CGRP immunoreactivity was markedly decreased to absent in adventitial nerve fibres in inflamed regions of vessels, which may reflect secretion from nerve terminals, as CGRP immunoreactivity could still be seen in nerve trunks in periadventitial tissue. Trk A immunoreactive nerve fibres were found in a similar distribution to CGRP containing nerve fibres in non-inflamed vessels, and the trk A immunoreactivity was virtually unchanged in inflamed vessels. The evidence supports a role for NGF related mechanisms in inflammatory vascular head pain. Anti-NGF or anti-trk A agents may represent novel analgesics in this condition.  (+info)

Calcitonin gene-related peptide rapidly downregulates nicotinic receptor function and slowly raises intracellular Ca2+ in rat chromaffin cells in vitro. (8/1567)

Although calcitonin gene-related peptide (CGRP) modulates muscle-type nicotinic acetylcholine receptors (nAChRs) via intracellular second messenger-mediated phosphorylation, the action of this peptide on neuronal-type nAChRs remains unknown. Using neuronal nAChRs of rat chromaffin cells in vitro we studied the effect of CGRP, which is physiologically present in adrenal medulla, on membrane currents and [Ca2+]i transients elicited by nicotine. Our main novel observation was that CGRP (either bath-applied or focally applied for a few seconds or even co-applied with nicotine for a few milliseconds) selectively and rapidly blocked nAChRs (a phenomenon unlikely caused by intracellular messengers in view of its speed) without affecting GABA receptors. The inhibitory effect of CGRP was independent of [Ca2+]i or membrane potential and not accompanied by baseline current changes. Like the competitive antagonist N,N,N-trimethyl-1-(4-trans-stilbenoxy)-2-propilammonium, CGRP induced a rightward, parallel shift of the nicotine dose-response curve; during co-application of these blockers the nicotine dose-ratio value was the sum of the values obtained with each antagonist alone. The block by CGRP was insensitive to the receptor antagonist hCGRP8-37 but mimicked by CGRP1-7. Persistent application of CGRP slowly increased [Ca2+]i, a phenomenon independent from external Ca2+, thus implying Ca2+ release from internal stores, and suppressed by hCGRP8-37. CGRP1-7 had no significant effect on [Ca2+]i. We propose that the 1-7 amino acid sequence of CGRP was responsible for the direct, rapid block of nAChRs, whereas the full-length peptide molecule was necessary for the delayed rise in internal Ca2+ potentially able to trigger phosphorylation-dependent modulation of nicotinic receptor function.  (+info)

Quantitative autoradiography reveals higher densities of specific calcitonin-gene-related peptide receptors in small...Quantitative autoradiography reveals higher densities of specific calcitonin-gene-related peptide receptors in small...
1. Binding sites for calcitonin-gene-related peptide were localized and characterized in porcine coronary arteries using quantitative autoradiography, and the density of binding sites was compared between large epicardial and small intramyocardial coronary arteries.. 2. A single class of binding sites for calcitonin-gene-related peptide with a dissociation constant of 2.1 ± 0.2 nmol/l was detected in both the large and small coronary arteries. The density of specific binding sites was higher (maximum binding site density 231 ± 14 fmol/mg of protein) in the small coronary arteries than in the large epicardial coronary arteries (maximum binding site density 108 ± 5 fmol/mg of protein). β-Human calcitonin-gene-related peptide showed higher affinity than α-human calcitonin-gene-related peptide for the binding sites. Most of the specific binding sites for both peptides in the large coronary artery were localized in the intima and media.. 3. In coronary artery from patients with coronary heart ...
http://www.clinsci.org/content/84/1/55
Origins of substance P- and calcitonin gene-related peptide-containing nerves in the internal carotid artery of ratOrigins of substance P- and calcitonin gene-related peptide-containing nerves in the internal carotid artery of rat
article{09c0a925-e49d-4f96-88c5-8518027b9c58, abstract = {An aggregation of substance P (SP)- and calcitonin gene-related peptide (CGRP)-containing nerve cells (internal carotid mini-ganglion) is described at the junction between the greater superficial petrosal nerve and the internal carotid nerve close to the internal carotid artery. A retrograde tracer dye technique demonstrates that this ganglion and the trigeminal and superior vagal ganglia supply the internal carotid artery with SP/CGRP fibers at, above and below this level, respectively. Implications of this finding for cranial painful syndromes in man are discussed.}, author = {Hardebo, Jan Erik and Suzuki, Norihiro and Owman, Christer}, issn = {0304-3940}, language = {eng}, number = {1}, pages = {39--45}, publisher = {Elsevier}, series = {Neuroscience Letters}, title = {Origins of substance P- and calcitonin gene-related peptide-containing nerves in the internal carotid artery of rat}, url = ...
https://lup.lub.lu.se/search/publication/1104674
Distinct substance P and calcitonin gene-related peptide immunoreactive nerves in the guinea pig eye. | IOVS | ARVO JournalsDistinct substance P and calcitonin gene-related peptide immunoreactive nerves in the guinea pig eye. | IOVS | ARVO Journals
Using a double labeling indirect immunofluorescent technique, we studied the guinea pig trigeminal ganglion and eye for co-localization of substance P and calcitonin gene-related peptide. In the trigeminal ganglion, the number of neurons immunoreactive for calcitonin gene-related peptide significantly outnumber those immunoreactive for substance P, but virtually all substance P positive neurons are immunoreactive for calcitonin gene-related peptide. In the eye, a complex pattern of co-localization is present; both peptides co-localize in most immunoreactive nerve fibers. Nerve fibers immunoreactive only for calcitonin gene-related peptide tend to be concentrated in the cornea and posterior ciliary body. Nerve fibers immunoreactive only for substance P are present in relation to both iris muscles. Sensory denervation by intracranial transection of the ophthalmic and maxillary nerves fails to eliminate these substance P positive but CGRP negative iris nerve fibers. These findings indicate an ...
http://iovs.arvojournals.org/article.aspx?articleid=2159769
Sensory nerve terminal activity in severe hypertension as reflected by circulating calcitonin gene-related peptide (CGRP) and...Sensory nerve terminal activity in severe hypertension as reflected by circulating calcitonin gene-related peptide (CGRP) and...
article{1857c827-237f-4c9c-bdcf-df90e3a1106c, abstract = {In patients with severe hypertension and in age and sex matched controls the circulating levels of calcitonin gene-related peptide-like immunoreactivity (CGRP-LI) and substance P-LI were measured. Samples were taken before medication, after 2-4 weeks and 2-12 months of pharmacological treatment to normotension. In the control group CGRP-LI levels were significantly higher for females than for males. No such relation was seen for substance P-LI. There were no correlations between CGRP-LI, substance P-LI or blood pressure. In the untreated acute hypertensive group there was a significant correlation between circulating levels of CGRP-LI and both diastolic and systolic blood pressure. No such relationship was seen for substance P-LI. The plasma levels of substance P-LI were significantly elevated (2.8 +/- 4.0) compared to controls (1.3 +/- 1.3, pmol/l, mean +/- S.D., p < 0.01). The levels of CGRP-LI did not differ from the control group. ...
https://lup.lub.lu.se/search/publication/1106479
Topical Calcitonin Gene-Related Peptide Increases Wound Closure in Sec by Darin Thomas DieckhoffTopical Calcitonin Gene-Related Peptide Increases Wound Closure in Sec by Darin Thomas Dieckhoff
TOPICAL CALCITONIN GENE-RELATED PEPTIDE INCREASES WOUND CLOSURE IN SECOND DEGREE CUTANEOUS BURNSBiologyMissouri State University, August 2012Master of ScienceDarin Thomas DieckhoffABSTRACTCutaneous thermal wounds result in significant tissue damage with loss of epidermis, nerve fibers, and vascular tissue, which increases healing time. Neuropeptides released by sensory neurons are implicated in the wound healing process. The 37-amino acid neuropeptide calcitonin gene-related peptide (CGRP) is a multifunctional protein that promotes vasodilation and proliferation of keratinocytes and endothelial cells. Based on the distribution of CGRP and its receptor in adult CD Hairless rats, we hypothesized that topical administration of CGRP to a cutaneous thermal wound would increase the rate of wound closure. Two 1.5 cm partial-thickness thermal wounds were created on the upper dorsal region of hairless rats (n = 6) by exposing tissues to 70o C water for 10 seconds. Each wound was covered with standard medical
https://bearworks.missouristate.edu/theses/2748/
Calcitonin gene-related peptide enhances release of native brain-derived neurotrophic factor from trigeminal ganglion neurons<...Calcitonin gene-related peptide enhances release of native brain-derived neurotrophic factor from trigeminal ganglion neurons<...
TY - JOUR. T1 - Calcitonin gene-related peptide enhances release of native brain-derived neurotrophic factor from trigeminal ganglion neurons. AU - Buldyrev, Ilya. AU - Tanner, Nathan M.. AU - Hsieh, Hui Ya. AU - Dodd, Emily G.. AU - Nguyen, Loi T.. AU - Balkowiec, Agnieszka. PY - 2006/12/1. Y1 - 2006/12/1. N2 - Activity-dependent plasticity in nociceptive pathways has been implicated in pathomechanisms of chronic pain syndromes. Calcitonin gene-related peptide (CGRP), which is expressed by trigeminal nociceptors, has recently been identified as a key player in the mechanism of migraine headaches. Here we show that CGRP is coexpressed with brain-derived neurotrophic factor (BDNF) in a large subset of adult rat trigeminal ganglion neurons in vivo. Using ELISA in situ, we show that CGRP (1-1000 nm) potently enhances BDNF release from cultured trigeminal neurons. The effect of CGRP is dose-dependent and abolished by pretreatment with CGRP receptor antagonist, CGRP(8-37). Intriguingly, CGRP-mediated ...
https://ohsu.pure.elsevier.com/en/publications/calcitonin-gene-related-peptide-enhances-release-of-native-brain--2
Regulation of calcitonin gene-related peptide gene expression by a met by Amanda C. HerbsterRegulation of calcitonin gene-related peptide gene expression by a met by Amanda C. Herbster
Release of calcitonin gene-related peptide (CGRP) from trigeminal sensory nerves is implicated in the underlying pathology of migraine. While the therapeutic benefits of grape seed extract (GSE) to inhibit pathophysiological mechanisms associated with cardiovascular disease are well known, the potential benefit of GSE to decrease neurogenic inflammation has not been investigated. The goal of my study was to determine whether GSE could inhibit CGRP expression in primary cultures of trigeminal ganglion neurons as well as a human cell line, DMS 153 cells. CGRP was significantly increased in primary rat trigeminal ganglia cultures in response to a depolarizing stimulus by KCl or capsaicin. Pretreatment with GSE repressed stimulated release of CGRP from trigeminal ganglion neurons. Similarly, GSE repressed stimulated human CGRP promoter activity and mitogen activated protein kinases (MAPK) reporter genes in DMS 153 cells. Moreover, overnight treatment with GSE suppressed basal human CGRP promoter activity.
https://bearworks.missouristate.edu/theses/2863/
Calcitonin gene-related peptide in experimental ischemia. Implication of an endogenous anti-ischemic effect<...Calcitonin gene-related peptide in experimental ischemia. Implication of an endogenous anti-ischemic effect<...
TY - JOUR. T1 - Calcitonin gene-related peptide in experimental ischemia. Implication of an endogenous anti-ischemic effect. AU - Gherardini, Giulio. AU - Evans, Gregory R D. AU - Theodorsson, Elvar. AU - Gurlek, Ali. AU - Milner, Stephen M.. AU - Palmer, Björn. AU - Lundeberg, Thomas. PY - 1996. Y1 - 1996. N2 - Ischemia resulting from flap harvesting and vascular manipulation during microsurgery may be responsible for flap ischemic sufferance and, ultimately, necrosis. Recently, the regulatory role of the sensory nervous system in ischemia has attracted much interest. Calcitonin gene-related peptide (CGRP), a neuropeptide, is a naturally occurring vasodilator with no constrictive effects. In the present study, we developed a model of partial, chronic ischemia in the rat epigastric flap and investigated the effects of ischemia on concentrations of CGRP-like immunoreactivity (-LI) in ischemic skin and in different regions of the rat brain (striatum, hippocampus, pituitary, hypothalamus, and ...
https://jhu.pure.elsevier.com/en/publications/calcitonin-gene-related-peptide-in-experimental-ischemia-implicat-3
Engineering ex vivo-expanded marrow stromal cells to secrete calcitonin gene-related peptide using adenoviral vector<...Engineering ex vivo-expanded marrow stromal cells to secrete calcitonin gene-related peptide using adenoviral vector<...
TY - JOUR. T1 - Engineering ex vivo-expanded marrow stromal cells to secrete calcitonin gene-related peptide using adenoviral vector. AU - Deng, Weiwen. AU - Bivalacqua, Trinity. AU - Chattergoon, Natasha N.. AU - Jeter, James R.. AU - Kadowitz, Philip J.. PY - 2004. Y1 - 2004. N2 - Calcitonin gene-related peptide (CGRP) is a target for cardiovascular gene therapy. Marrow stromal cells (MSCs) hold promise for use in adult stem cell-based cell and gene therapy. To determine the feasibility of adenoviral-mediated CGRP gene transfer into ex vivo-expanded MSCs, rat MSCs were isolated, ex vivo expanded, and transduced with adenoviruses. Adprepro-CGRP and AdntlacZ, adenoviral vectors containing prepro-CGRP or nuclear-targeted β-galactosidase reporter gene ntlacZ under the control of Rous sarcoma virus promoter, were used. In this study, it can be shown that transduction efficiency of adenoviral-mediated gene transfer into ex vivo-expanded MSCs is dose dependent, transgene expression persists for more ...
https://jhu.pure.elsevier.com/en/publications/engineering-ex-vivo-expanded-marrow-stromal-cells-to-secrete-calc-3
Activin and bone morphogenetic proteins induce calcitonin gene-related peptide in embryonic sensory neurons in vitroActivin and bone morphogenetic proteins induce calcitonin gene-related peptide in embryonic sensory neurons in vitro
The neuropeptide calcitonin gene-related peptide (CGRP) expressed by one-third of rat dorsal root ganglion (DRG) neurons mediates pain sensation and vasodilation. The developmental regulation of CGRP is poorly understood, but may involve target-derived factors from skin or viscera. Few embryonic DRG …
https://pubmed.ncbi.nlm.nih.gov/10656256/?dopt=Abstract
Activation of calcitonin gene-related peptide signaling through the prostaglandin E2-EP1/EP2/EP4 receptor pathway in synovium...Activation of calcitonin gene-related peptide signaling through the prostaglandin E2-EP1/EP2/EP4 receptor pathway in synovium...
Calcitonin gene-related peptide (CGRP) is a 37-amino-acid vasodilatory neuropeptide that binds to receptor activity-modifying protein 1 (RAMP1) and the calcitonin receptor-like receptor (CLR). Clinical and preclinical evidence suggests that CGRP is associated with hip and knee joint pain; however, the regulation mechanisms of CGRP/CGRP receptor signaling in synovial tissue are not fully understood. Synovial tissues were harvested from 43 participants with radiographic knee osteoarthritis (OA; unilateral Kellgren/Lawrence (K/L) grades 3-4) during total knee arthroplasty. Correlationships between the mRNA expression levels of CGRP and those of tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, IL-6, and cycloxygenase-2 (COX-2) were evaluated using real-time PCR analysis of total RNA extracted from the collected synovial tissues. To investigate the factors controlling the regulation of CGRP and CGRP receptor expression, cultured synovial cells were stimulated with TNF-α, IL-1β, IL-6, and
https://josr-online.biomedcentral.com/articles/10.1186/s13018-016-0460-4
Effects of glyceryl trinitrate and calcitonin-gene-related peptide on BOLD signal and arterial diameter -methodological studies...Effects of glyceryl trinitrate and calcitonin-gene-related peptide on BOLD signal and arterial diameter -methodological studies...
Over the last decades MRI has proved to be very useful in the field of drug development and discovery. Pharmacological MRI (phMRI) explores the interaction between brain physiology, neuronal activity and drugs[1]. The BOLD-signal is an indirect method to investigate brain activity by way of measuring task-related hemodynamic changes. Pharmacological substances that induce hemodynamic changes can therefore potentially alter the BOLD-signal that in turn falsely can be interpreted as changes in neuronal activity. It is therefore important to characterize possible effects of a pharmacological substance on the BOLD-response per see before that substance can be used in an fMRI experiment. Furthermore MR-angiography is useful in determining the vascular site-of-action of vasoactive substances ...
http://www.forskningsdatabasen.dk/catalog/245600728
Characterization of the human calcitonin-gene-related peptide receptor | Biochemical Society TransactionsCharacterization of the human calcitonin-gene-related peptide receptor | Biochemical Society Transactions
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http://www.biochemsoctrans.org/content/15/4/714
What is the role of calcitonin gene-related peptide (CGRP) in the pathogenesis of anaphylaxis?What is the role of calcitonin gene-related peptide (CGRP) in the pathogenesis of anaphylaxis?
Calcitonin gene-related peptide (CGRP), a sensory neurotransmitter that is widely distributed in cardiovascular tissues, may help to counteract coronary artery vasoconstriction during anaphylaxis. CGR... more
https://www.medscape.com/answers/135065-52856/what-is-the-role-of-calcitonin-gene-related-peptide-cgrp-in-the-pathogenesis-of-anaphylaxis
CLIA Kit for Calcitonin Gene Related Peptide (CGRP) | CCA876Ra | Rattus norvegicus (Rat) CLOUD-CLONE CORP.(CCC)CLIA Kit for Calcitonin Gene Related Peptide (CGRP) | CCA876Ra | Rattus norvegicus (Rat) CLOUD-CLONE CORP.(CCC)
CCA876Ra, CALCB; CGRP2; CALC2; CGRP-II; Calcitonin Gene Related Peptide 2; Calcitonin 2; Calcitonin Related Polypeptide Beta | Products for research use only!
http://cloud-clone.com/products/CCA876Ra.html
Plus itPlus it
The sensory neuropeptide calcitonin gene-related peptide (CGRP) plays a role in primary headaches and CGRP receptor antagonists are effective in migraine treatment. CGRP is a potent vasodilator raising the possibility that antagonism of its receptor could have cardiovascular effects. We therefore investigated the effects of the anti-migraine CGRP receptor antagonist telcagepant (MK-0974) on human isolated coronary arteries. Arteries with different internal diameters (ID) were studied to assess the potential for differential effects across the coronary vascular bed. The concentration-dependent relaxation responses to human αCGRP were greater in distal (ID: 600-1000 μm, Emax=83±7%) than proximal coronary arteries (ID: 2-3 mm, Emax=23±9%), coronary arteries from explanted hearts (ID 3-5 mm, Emax=11±3%) and coronary arterioles (ID: 200-300 μm, Emax=15±7%). Telcagepant alone did not induce contraction or relaxation of these coronary blood vessels. Pre-treatment with telcagepant (10 nM to 1 ...
http://jpet.aspetjournals.org/content/early/2010/06/28/jpet.110.165993
NIOSHTIC-2 Publications Search - 20039032 - Changes in the expression of calcitonin gene-related peptide after exposure to...NIOSHTIC-2 Publications Search - 20039032 - Changes in the expression of calcitonin gene-related peptide after exposure to...
Muscle inflammation and hyperalgesia induced by adjuvant injection into skeletal muscle are associated with an increase in calcitonin gene-related peptide (CGRP) labeling in skeletal muscle and dorsal root ganglia (DRG). This increased expression of CGRP may contribute to the maintenance of pain in these models. However, it is not known if inflammation induced by repetitive exposure to stretch-sho
https://www.cdc.gov/niosh/nioshtic-2/20039032.html
Calcitonin Gene Products: Molecular Biology, Chemistry, and Actions | Springer for Research & DevelopmentCalcitonin Gene Products: Molecular Biology, Chemistry, and Actions | Springer for Research & Development
Calcitonin was discovered by C opp et al. (1961) as a hypocalcemic hormone and the neuropeptide calcitonin gene-related peptide (CGRP) recognized through analysis of the calcitonin gene structure (A...
https://rd.springer.com/chapter/10.1007/978-3-642-77991-6_16
Role of CGRP-Receptor Component Protein (RCP) in CLR/RAMP Function | Bentham ScienceRole of CGRP-Receptor Component Protein (RCP) in CLR/RAMP Function | Bentham Science
Title:Role of CGRP-Receptor Component Protein (RCP) in CLR/RAMP Function. VOLUME: 14 ISSUE: 5. Author(s):Ian M. Dickerson. Affiliation:University of Rochester, Department of Neurobiology & Anatomy, 601 Elmwood Avenue, Box 603, Rochester, NY 14642, USA.. Keywords:Calcitonin gene-related peptide, adrenomedullin, calcitonin-like receptor, receptor activity modifying protein, CGRP-receptor component protein, signal transduction, trafficking.. Abstract:The receptor for calcitonin gene-related peptide (CGRP) and adrenomedullin (AM) requires an intracellular peripheral membrane protein named CGRP-receptor component protein (RCP) for signaling. RCP is required for CGRP and AM receptor signaling, and it has recently been discovered that RCP enables signaling by binding directly to the receptor. RCP is present in most immortalized cell lines, but in vivo RCP expression is limited to specific subsets of cells, usually co-localizing with CGRP-containing neurons. RCP protein expression correlates with CGRP ...
http://www.eurekaselect.com/113128/article?tracking-code=4
Amylin calcitonin gene related peptide and adrenomedullin a superfamilAmylin calcitonin gene related peptide and adrenomedullin a superfamil
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http://buysemax.com/amylin-calcitonin-gene-related-peptide-and-adrenomedullin-a-superfamil.html
Calcitonin gene-related peptide does not excite or sensitize meningeal nociceptors: Implications for the pathophysiology of...Calcitonin gene-related peptide does not excite or sensitize meningeal nociceptors: Implications for the pathophysiology of...
Migraine is among the most common types of pain, but its mechanisms are poorly understood. A growing body of evidence points to a critical role of calcitonin gene-related peptide (CGRP) in the pathophysiology of migraine headache. During migraine, CGRP is thought to be released from peripheral endings of perivascular meningeal nociceptors primary and to promote vasodilatation. A current hypothesis suggests that peripheral CGRP and its related meningeal vasodilatation results in activation and sensitization, leading to the generation of migraine headache. However, direct evidence supporting this idea is lacking. Here, using electrophysiological, extracellular, single-unit recording combined with laser-Doppler flowmetry measurements of dural blood flow (DBF), we examined whether CGRP and meningeal vasodilatation promote activation or sensitization of meningeal nociceptors. Changes in (DBF), ongoing discharge, and responsiveness to mechanical stimulation of the dura were studied after either ...
http://onlinelibrary.wiley.com/doi/10.1002/ana.20619/full?globalMessage=0
Calcitonin Gene Related Peptide (CGRP) - Pipeline Review, H2 2019 - Global Markets DirectsCalcitonin Gene Related Peptide (CGRP) - Pipeline Review, H2 2019 - Global Markets Directs
Global Markets Directs, Calcitonin Gene Related Peptide (CGRP) - Pipeline Review, H2 2018, provides in depth analysis on Calcitonin Gene
https://www.globalmarketsdirect.com/report/gmdhc2019tdb--calcitonin-gene-related-peptide-cgrp-pipeline-review-h2-2019/
Phosphodiesterases 3 and 5 express activity in the trigeminal ganglion and co-localize with calcitonin gene-related peptide -...Phosphodiesterases 3 and 5 express activity in the trigeminal ganglion and co-localize with calcitonin gene-related peptide -...
Understanding of the neuropathology leading to migraine pain has centered on either a vascular or neuronal origin. Sildenafil, a specific inhibitor of phosphodiesterase 5 (PDE5), induces migraine-like headache in a human headache model without concomitant artery dilation. The presence and activity of PDE3 and PDE5 is known in cerebral arteries. However, the presence in the neuronal part of the trigeminovascular pathway, i.e. the trigeminal ganglion and the possible co-localization with calcitonin gene-related peptide (CGRP), is not known ...
http://www.forskningsdatabasen.dk/catalog/261358469
CGRP elisa kit | Fish Calcitonin Gene Related Peptide ELISA Kit-NP 001095943.1CGRP elisa kit | Fish Calcitonin Gene Related Peptide ELISA Kit-NP 001095943.1
Buy CGRP elisa kit, Fish Calcitonin Gene Related Peptide ELISA Kit-NP_001095943.1 (MBS029789) product datasheet at MyBioSource, ELISA Kits
https://www.mybiosource.com/prods/ELISA-Kit/Fish/Calcitonin-Gene-Related-Peptide/CGRP/datasheet.php?products_id=29789
Calcitonin gene-related peptide and muscle activity regulate acetylcholine receptor alpha-subunit mRNA levels by distinct...Calcitonin gene-related peptide and muscle activity regulate acetylcholine receptor alpha-subunit mRNA levels by distinct...
In cultured chicken myotubes, calcitonin gene-related peptide (CGRP), a peptide present in spinal cord motoneurons, increased by 1.5-fold the number of surface acetylcholine receptors (AChRs) and by threefold AChR alpha-subunit mRNA level without affecting the level of muscular alpha-actin mRNA. Cholera toxin (CT), an activator of adenylate cyclase, produced a similar effect, which did not add up with that of CGRP. In contrast, tetrodotoxin, a blocker of voltage-sensitive Na+ channels, elevated the level of AChR alpha-subunit mRNA on top of the increase caused by either CGRP or CT. 12-O-Tetradecanoyl phorbol-13-acetate (TPA), an activator of protein kinase C, markedly decreased the cell surface and total content of [125I]alpha BGT-binding sites and reduced the rate of appearance of AChR at the surface of the myotubes without reducing the level of AChR alpha-subunit mRNA. Moreover, TPA inhibited the increase of AChR alpha-subunit mRNA caused by tetrodotoxin without affecting that produced by CGRP ...
http://jcb.rupress.org/content/105/3/1337
Calcitonin Gene Related Peptide : Severn Biotech, LimitedCalcitonin Gene Related Peptide : Severn Biotech, Limited
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Plus itPlus it
We previously found that capsaicin can dilate third-order arterioles in striated muscle by a mechanism that appears to involve release of endogenous calcitonin gene-related peptide (CGRP). Experiments were done to determine 1) whether capsaicin has similar effects on larger arterioles and venules and 2) whether relaxation involves endogenous CGRP and synthesis of endothelium-derived relaxing factor. In male Sprague-Dawley rats anesthetized with pentobarbital (50 mg/kg, i.p.), we examined responses of first- and second-order microvessels in the cremaster muscle using video microscopy. Addition of capsaicin (0.1 microgram/ml) to vessels constricted by norepinephrine (10(-7) M) dilated 1As by 91% +/- 28%, 2As by 113% +/- 18% 1Vs by 11% +/- 6% and 2Vs by 42% +/- 18%. Capsaicin in the presence of the specific CGRP receptor antagonist CGRP (8-37) caused an attenuated arteriolar dilation but had no significant venodilatory effect (1As 29% +/- 18%, 2As 55% +/- 14%, 1Vs 7% +/- 3%, 2Vs 16% +/- ...
http://jpet.aspetjournals.org/content/273/2/605
Leicester Research Archive: Depletion of substance P and calcitonin gene-related peptide in sciatic nerve of rats with...Leicester Research Archive: Depletion of substance P and calcitonin gene-related peptide in sciatic nerve of rats with...
Depletion of substance P and calcitonin gene-related peptide in sciatic nerve of rats with experimental diabetes; effects of insulin and aldose reductase ...
https://lra.le.ac.uk/handle/2381/23105
PRIME PubMed | Role of anandamide transporter in regulating calcitonin gene-related peptide production and blood pressure in...PRIME PubMed | Role of anandamide transporter in regulating calcitonin gene-related peptide production and blood pressure in...
PubMed journal article: Role of anandamide transporter in regulating calcitonin gene-related peptide production and blood pressure in hypertension. Download Prime PubMed App to iPhone, iPad, or Android
https://www.unboundmedicine.com/medline/citation/19462497/Role_of_anandamide_transporter_in_regulating_calcitonin_gene_related_peptide_production_and_blood_pressure_in_hypertension_
Papers with the keyword Intracranial Haemorrage | Read by QxMDPapers with the keyword Intracranial Haemorrage | Read by QxMD
Calcitonin gene related peptide (CGRP), a 37 amino acid neuropeptide, is the most potent vasodilator known. Participation of CGRP in hypertension and related diseases, such as preeclampsia or vasospasm after subarachnoid haemorrage, is one of the most studied topics. In this review we summarize the published roles of CGRP in pathophysiology of hypertension in humans and in experimental models. We also discuss the effects of direct administration of CGRP in the treatment of hypertension and of anti-hypertensive drugs that enhance the release or response of endogenous calcitonin gene-related peptide: angiotensin converting enzyme inhibitors, selective antagonists for the angiotensin II receptor, beta-blockers, magnesium sulphate for preeclampsia and rutaecarpine, as well as the possibilities using CGRP in gene therapy for prevention of vasospasm after subarachnoid haemorrage ...
https://www.readbyqxmd.com/keyword/60758
Ian M. Dickerson, Ph.D. - University of Rochester Medical CenterIan M. Dickerson, Ph.D. - University of Rochester Medical Center
Our laboratory studies the neuropeptide calcitonin gene-related peptide (CGRP). Originally discovered as an alternatively-spliced variant of the calcitonin mRNA, CGRP is one of the most potent vasodilators known. As a vasodilator, CGRP has both peripheral and central effects. One of the most notable effects of CGRP is its causative effect of migraine on the cerebral vasculature, and stable synthetic antagonists have been recently developed and are in Stage III clinical trials for migraine treatment. CGRP also suppresses immune function, is involved in pain perception, and has further central role in the development of tolerance to opiates ...
https://www.urmc.rochester.edu/people/26563633-ian-m-dickerson/patients
RAMP3 receptor activity modifying protein 3 [Homo sapiens (human)] - Gene - NCBIRAMP3 receptor activity modifying protein 3 [Homo sapiens (human)] - Gene - NCBI
The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP3) protein, CRLR functions as an adrenomedullin receptor. [provided by RefSeq, Jul 2008 ...
https://www.ncbi.nlm.nih.gov/gene/10268
Iain MacIntyre. 30 August 1924 - 18 September 2008 | Biographical Memoirs of Fellows of the Royal SocietyIain MacIntyre. 30 August 1924 - 18 September 2008 | Biographical Memoirs of Fellows of the Royal Society
After a long illness borne with much grace and dignity, Iain MacIntyre died in London on 18 September 2008. He had led a most distinguished career over five decades as a major figure in the field of calcium-regulating hormones and bone metabolism, with his many scientific achievements marked by originality as well as biological and medical importance. Among his many accomplishments were the co-discovery with Harold Copp of the hormone calcitonin, whose glandular origin, structure and biological and medical functions he defined. Iain also was the first to isolate and sequence, with colleagues, the novel human neuropeptide calcitonin gene-related peptide, demonstrating its role as a potent vasodilator. Subsequently Iain defined the multiple phenotypic consequences attributable to nitric oxide production by different enzymes in a tissue-specific fashion. A major educational contribution was in conceiving and organizing an important biennial series of international endocrine meetings held between ...
http://rsbm.royalsocietypublishing.org/content/roybiogmem/early/2012/02/15/rsbm.2011.0025
Detailed Information (TTD) -- BIDDDetailed Information (TTD) -- BIDD
J Med Chem. 2008 Aug 28;51(16):4858-61. Epub 2008 Jul 30.Discovery of (R)-4-(8-fluoro-2-oxo-1,2-dihydroquinazolin-3(4H)-yl)-N-(3-(7-methyl-1H-indazol-5-yl)-1-oxo-1-(4-(piperidin-1-yl)piperidin-1-yl)propan-2-yl)piperidine-1-carboxamide (BMS-694153): a potent antagonist of the human calcitonin gene-related peptide receptor for migraine with rapid and efficient intranasal exposure. To Reference ...
http://bidd.nus.edu.sg/group/TTD/ZFTTDDetail.asp?ID=TTDS00475
Abstract 820: Autoregulation of CGRP Expression via β2-Adrenoreceptor Signaling in Intrinsic Cardiac Adrenergic Cells |...Abstract 820: Autoregulation of CGRP Expression via β2-Adrenoreceptor Signaling in Intrinsic Cardiac Adrenergic Cells |...
Background: Calcitonin gene-related peptide (CGRP) is a neuropeptide with broad salutary cardiovascular effects. Mechanisms underlying cardiac CGRP regulation are poorly understood. The intrinsic cardiac adrenergic (ICA) cell is a novel cardiac neuroendocrine cell that expresses the δ-opioid receptor. We have shown that δ-opioid stimulation of ICA cells induces epinephrine liberation exerting an infarct-size limiting effect via β2-adrenoreceptor (β2-AR) stimulation. In this study we hypothesize that ICA cells synthesize and release CGRP which is involved in myocardial function and that CGRP gene expression can be autoregulated by epinephrine released from the ICA cell or regulated exogenously via β2-AR agonist.. Methods and Results: In situ hybridization coupled with immunofluorescent double labeling localized CGRP mRNA expression exclusively to ICA cells in explanted human left ventricular tissue. To determine whether δ-opioid-enhanced epinephrine release from ICA cells autoregulates CGRP ...
http://circ.ahajournals.org/content/116/Suppl_16/II_159.2
Sensory hypoinnervation in club foot by M Ahmed, N Ahmed et al.Sensory hypoinnervation in club foot by M Ahmed, N Ahmed et al.
Abstract We have compared the density of nerve fibres in the synovium in club foot with that of specimens obtained from the synovium of the hip at operations for developmental dysplasia. The study focused on the sensory neuropeptides substance P; calcitonin gene-related peptide; protein gene product 9.5, a general marker for mature peripheral nerve fibres; and growth associated protein 43, a neuronal marker for new or regenerating nerve fibres. In order to establish whether there might be any inherent difference we analysed the density of calcitonin gene-related peptide-positive nerve fibres in the hip and ankle joints in young rats. Semi-quantitative analysis showed a significant reduction in the number of sensory and mature nerve fibres in the synovium in club foot compared with the control hips. Calcitonin gene-related peptide (CGRP) positive fibres were reduced by 28%, substance P-positive fibres by 36% and protein gene product 9.5-positive fibres by 52% in club foot. The growth associated protein
https://ecommons.aku.edu/pakistan_fhs_mc_surg_surg/227/
Purification and characterization of a peptide from amyloid-rich pancreases of type 2 diabetic patients | PNASPurification and characterization of a peptide from amyloid-rich pancreases of type 2 diabetic patients | PNAS
Deposition of amyloid in pancreatic islets is a common feature in human type 2 diabetic subjects but because of its insolubility and low tissue concentrations, the structure of its monomer has not been determined. We describe a peptide, of calculated molecular mass 3905 Da, that was a major protein component of amyloid-rich pancreatic extracts of three type 2 diabetic patients. After collagenase treatment, an extract containing 20-50% amyloid was solubilized by sonication into 70% formic acid and the peptide was purified by gel filtration followed by reverse-phase high-performance liquid chromatography. We term this peptide diabetes-associated peptide, as it was not detected in extracts of pancreas from any of six normal subjects. Diabetes-associated peptide contains 37 amino acids and is 46% identical to the sequences of rat and human calcitonin gene-related peptide, indicating that these peptides are related in evolution. Sequence identities with conserved residues of the insulin A chain were ...
https://www.pnas.org/content/84/23/8628?ijkey=f25cdddc0cc318e0d8afc0f17f854d427b72813e&keytype2=tf_ipsecsha
Baum, O<...Baum, O<...
Schuler, B; Rieger, G; Gubser, M; Arras, M; Gianella, M; Vogel, O; Jirkof, P; Cesarovic, N; Klohs, J; Jakob, P; Brock, M; Gorr, T A; Baum, O; Hoppeler, H; Samillan-Soto, V; Gassmann, M; Fischer, J A; Born, W; Vogel, J (2014). Endogenous α-calcitonin-gene-related peptide promotes exercise-induced, physiological heart hypertrophy in mice. Acta Physiologica, 211(1):107-121.. Hlushchuk, R; Ehrbar, M; Reichmuth, P; Heinimann, N; Styp-Rekowska, B; Escher, R; Baum, O; Lienemann, P; Makanya, A; Keshet, E; Djonov, V (2011). Decrease in VEGF expression induces intussusceptive vascular pruning. Arteriosclerosis, Thrombosis, and Vascular Biology, 31(12):2836-2844.. Richter, V; Savery, M D; Gassmann, M; Baum, O; Damiano, E; Pries, A R (2011). Excessive erythrocytosis compromises the blood-endothelium interface in erythropoietin-overexpressing mice. Journal of Physiology, 589(21):5181-5192.. Picard, N; Baum, O; Vogetseder, A; Kaissling, B; Le Hir, M (2008). Origin of renal myofibroblasts in the model of ...
http://www.zora.uzh.ch/view/authors_for_linking_in_citation/Baum=3AO=3A=3A.html
Calcitonin Gene-Related Peptide in the Bed Nucleus of the Stria Terminalis Produces an Anxiety-Like Pattern of Behavior and...Calcitonin Gene-Related Peptide in the Bed Nucleus of the Stria Terminalis Produces an Anxiety-Like Pattern of Behavior and...
The goals of this study were to evaluate the influence of CGRP within the BNST on anxiety and on neural activation patterns. We found that intra-BNST CGRP infusions produced an anxiogenic behavioral profile and enhanced neural activation in a number of anxiety-related brain areas, and that antagonism of these receptors prevented anxiety-like responses to TMT odor. CGRP infused bilaterally into the BNST enhanced the acoustic startle response in a dose-dependent manner (experiment 1). This increase was attenuated by prior administration of the CGRP antagonist, αCGRP8-37, at a dose that did not significantly affect startle when given alone (experiment 2). This suggests that the effects on startle were indeed mediated by activation of CGRP receptors. Intra-BNST CGRP infusions (800 ng/side) also decreased the percentage of time spent on the open arms and the percentage of total entries into the open arms of the elevated plus maze (experiment 6). These anxiety-like behavioral results are consistent ...
https://www.jneurosci.org/content/31/5/1802?ijkey=9000db241caf815f67fcd61dc5d6a18939e569a9&keytype2=tf_ipsecsha
siRNA, DsiRNA and Plasmid Transfection Efficiency: Raf-1- selective siRNA and Response to PainsiRNA, DsiRNA and Plasmid Transfection Efficiency: Raf-1- selective siRNA and Response to Pain
Background and purpose: Long-term morphine treatment enhances pain neurotransmitter (such as calcitonin gene-related peptide (CGRP)) levels in the spinal cord. It has been suggested previously that increased spinal CGRP may contribute to sustained morphine-mediated paradoxical pain sensitization and antinociceptive tolerance. Previous in vitro studies from our group indicated that Raf-1 kinase-mediated adenylyl cyclase superactivation played a crucial role in sustained morphine-mediated augmentation of basal and evoked CGRP release from cultured primary sensory neurons. The present study was aimed to evaluate the physiological significance of this molecular mechanism in vivo, in rats ...
http://sirnatransfection.blogspot.com/2010/05/raf-1-selective-sirna-and-response-to.html
RePub, Erasmus University Repository: Long-lasting physiological antagonism of calcitonin gene-related peptide towards...RePub, Erasmus University Repository: Long-lasting physiological antagonism of calcitonin gene-related peptide towards...
Endothelin-1 causes long-lasting contraction via endothelin type A receptor (ETAR) in isolated rat mesenteric arteries (RMA) that cannot be readily terminated by removing the agonist, or by adding the ETAR antagonist BQ123 or the NO donor sodium nitroprusside. It could be terminated by adding calcitonin-gene related peptide (CGRP), most likely because CGRP causes ET-1/ETAR dissociation. Here we investigated this phenomenon in human coronary microarteries (HCMA). We simultaneously verified the effects of CGRP in RMA and HCMA towards other vasoconstrictors, i.e., the α1- adrenoceptor agonist phenylephrine, the thromboxane A2 analog U46619 (9,11-dideoxy-11α,9α-epoxy-methano-prostaglandin F 2α) and KCl. Long-lasting contraction (remaining after washing away the agonist) was observed for ET-1 in RMA, but not HCMA. Constrictions to phenylephrine, U46619 or KCl did not last upon washing. When added on top of ET-1-initiated contraction in RMA, CGRP effectively counteracted vasoconstriction, i.e., it ...
https://repub.eur.nl/pub/65228
Rapid Communication: Salt-Sensitive Hypertension Induced by Sensory Denervation | HypertensionRapid Communication: Salt-Sensitive Hypertension Induced by Sensory Denervation | Hypertension
The present study demonstrated for the first time that neonatal degeneration of capsaicin-sensitive sensory nerves in rats leads to a significant increase in blood pressure when a high sodium diet is given. This observation is important because it has been shown that (1) substantial decreases in CGRP-containing sensory nerves in the mesenteric arterial bed occur in spontaneously hypertensive rats (SHR),6 7 indicating that there are inherited abnormalities in either generation or maintenance of sensory nerves in SHR; (2) the plasma CGRP concentration is lower in adult SHR than in age-matched normotensive control rats, indicating that release of CGRP from sensory nerves is decreased in SHR21 ; and (3) vasodilator responses to exogenous CGRP increase with age in SHR, suggesting that sensitivity of receptors to CGRP is increased due to the decreased release of CGRP from sensory nerves.6 7 The defect in sensory vasodilator function may produce an imbalance that could contribute to the development and ...
http://hyper.ahajournals.org/content/32/4/649
ORBi: Browsing ORBiORBi: Browsing ORBi
in Journal of Pharmacology and Experimental Therapeutics (The) (1994), 270(1), 30-6. The effects of calcitonin gene-related peptide (CGRP) (6 x 10(-8) M) on hemodynamics and on pulmonary microvascular permeability were investigated in isolated, perfused rabbit lungs by measuring the ... [more ▼]. The effects of calcitonin gene-related peptide (CGRP) (6 x 10(-8) M) on hemodynamics and on pulmonary microvascular permeability were investigated in isolated, perfused rabbit lungs by measuring the arterial, capillary and venous pressures and the capillary filtration coefficient (Kf,c). CGRP was administered alone or in combination with capsaicin (10(-4) M), acetylcholine (ACh) (10(-11) M to 10(-7) M), substance P (SP) (10(-10) M to 10(-6) M) and serotonin (10(-4) M). The influence of a specific antagonist of CGRP receptors, CGRP8-37 (10(-8) M), on the pulmonary edema induced by these mediators was also considered. CGRP had no direct effect on the vascular pressures or on Kf,c. Capsaicin and ...
http://orbi.ulg.ac.be/browse?type=journal&value=Journal+of+Pharmacology+and+Experimental+Therapeutics+
Einfluss von Calcitonin Gene-Related Peptide und Substance P auf die mRNA-Expression und Freisetzung von Zytokinen aus...Einfluss von Calcitonin Gene-Related Peptide und Substance P auf die mRNA-Expression und Freisetzung von Zytokinen aus...
Die bakterielle Meningitis (BM) ist trotz antibiotischer Therapie eine Erkrankung mit einer hohen Mortalität und Morbidität. Kopfschmerzen und Meningismus sind Hauptsymtome und ein klinischer Hinweis für die Aktivierung trigeminaler Fasern. Ziel dieser Arbeit war es zu prüfen ob die freigesetzten Neuropeptide einen proinflammatorischen Effekt auf zerebrale Endothelzellen, einen wesentlichem Bestandteil der Blut-Hirn-Schranke haben. Wir verwendeten primär kultivierte zerebrale Kapillarendothelzellen (BMEC) der Ratte und als Stimulus Neuropeptide und/oder Pneumokokkenzellwände (PCW). Beide Neuropeptide, CGRP mehr als SP, verstärken den Effekt von PCW auf die mRNA Expression und Freisetzung von TNF-alpha, IL-1beta, IL-6, IL-10 und MIP-2 aus den BMEC. CGRP und SP haben nur eine geringe Wirkung. PCW regulieren die Dichte der CRLR (CGRP1-R) bzw. NK-1 Rezeptoren und erklären damit die kostimulatorische Wirkung. Zudem untersuchten wir den Effekt von PCW und/oder CGRP auf die Adrenomedullin (AM)- ...
https://edoc.hu-berlin.de/handle/18452/15312
TumorPortalTumorPortal
This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin by tissue-specific alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins. Calcitonin is involved in calcium regulation and acts to regulate phosphorus metabolism. Calcitonin gene-related peptide functions as a vasodilator while katacalcin is a calcium-lowering peptide. Multiple transcript variants encoding different isoforms have been found for this gene ...
http://www.tumorportal.org/view?geneSymbol=CALCA
Prevention of stress- or nitric oxide donor-induced medication overuse headache by a calcitonin gene-related peptide antibody...Prevention of stress- or nitric oxide donor-induced medication overuse headache by a calcitonin gene-related peptide antibody...
TY - JOUR. T1 - Prevention of stress- or nitric oxide donor-induced medication overuse headache by a calcitonin gene-related peptide antibody in rodents. AU - Kopruszinski, Caroline Machado. AU - Xie, Jennifer Yanhua. AU - Eyde, Nathan Mackenzie. AU - Remeniuk, Bethany. AU - Walter, Sarah. AU - Stratton, Jennifer. AU - Bigal, Marcelo. AU - Chichorro, Juliana Geremias. AU - Dodick, David. AU - Porreca, Frank. PY - 2017/5/1. Y1 - 2017/5/1. N2 - Objective The objective of this study was the determination of the role of calcitonin gene-related peptide (CGRP) in the induction of medication overuse headache (MOH)-related migraine in an injury-free preclinical model. Methods Rats were primed by a 7-day period of exposure to acute migraine therapies including sumatriptan and morphine. After an additional 14-day drug-free period, rats were exposed to putative migraine triggers including bright light stress (BLS) or nitric oxide (NO) donor in the presence or absence of TEV48125, a fully humanized CGRP ...
https://arizona.pure.elsevier.com/en/publications/prevention-of-stress-or-nitric-oxide-donor-induced-medication-ove
Dietary Sodium Loading Increases Arterial Pressure in Afferent Renal-Denervated Rats | HypertensionDietary Sodium Loading Increases Arterial Pressure in Afferent Renal-Denervated Rats | Hypertension
Numerous studies have shown that severing the dorsal roots, ie, the afferent nerves proximal to the dorsal root ganglia, reduces the number of substance P- and calcitonin gene-related peptide-containing nerves in the dorsal horn.21 There are few studies examining the effects of DRX on peripheral afferent innervation. However, there are reports showing that DRX at T6-L2 and L6/S1 reduced the number of substance P- and calcitonin gene-related peptide-containing nerves around the hepatic artery and portal vein22 and in urinary bladder,23 respectively. Therefore, we examined whether the responsiveness of afferent renal nerves was altered by DRX. Three weeks after DRX, increasing renal pelvic pressure failed to increase ARNA. The lack of ARNA responses in DRX rats was even more conspicuous considering that the rats were fed the HNa diet. In agreement with our previous studies,5 increasing renal pelvic pressure resulted in marked increases in ARNA in the sham-DRX rats fed an HNa diet. Further studies ...
http://hyper.ahajournals.org/content/42/5/968
Expression of calcitonin gene-related peptide in the infrapatellar fat pad in knee osteoarthritis patients | Journal of...Expression of calcitonin gene-related peptide in the infrapatellar fat pad in knee osteoarthritis patients | Journal of...
The infrapatellar fat pad (IPFP) has been implicated as a possible source of osteoarthritis (OA) development and knee pain due to the production of inflammatory mediators and the existence of nerve fibers within this structure. Calcitonin gene-related peptide (CGRP) is a vasodilatory neuropeptide that is localized to joint tissues and has recently been implicated in the development of knee OA and OA pain. To date, however, the expression levels of CGRP in the IPFP of human knee OA patients have not been examined. IFFP and synovial (SYN) tissues were harvested from 100 individuals with radiographic knee OA (unilateral Kellgren/Lawrence [K/L] grades 2-4) during total knee arthroplasty and subjected to immunohistochemical analysis for CGRP localization. In addition, the messenger RNA (mRNA) expression levels of CGRP and cyclooxygenase-2 (COX-2) in the collected tissues were evaluated and compared using real-time PCR analysis of total RNA extracts. CGRP and COX-2 mRNA expression were also compared among
https://josr-online.biomedcentral.com/articles/10.1186/s13018-017-0568-1
The New Era Of Disease Modifying Migraine Drugs (DMMDs) - On HealthThe New Era Of Disease Modifying Migraine Drugs (DMMDs) - On Health
The trigeminal vascular system is a key player in the pathophysiology of migraine. Migraines are thought to be triggered when internal or environmental factors are of sufficient intensity to initiate the hyper excitement and activation of the trigeminal nerves. This activation provokes the release of neuroinflammatory mediators resulting in neurogenic inflammation, vasodilation, nociceptor activation, and propagation of pain response.. Some of the most important neuropeptides released in migraine attacks are Calcitonin Gene Related Peptide (CGRP), Substance P, and Serotonin.. Calcitonin Gene Related Peptide (CGRP). Migraine treatment has almost always relied on re-purposing medication developed to treat other conditions. However, the past decade has been tremendous for discoveries in migraine research and breakthroughs in migraine therapy. The aforementioned inflammatory neuropeptide Calcitonin Gene Related Peptide (CGRP) has played a major role in this march towards bespoke, novel targeted ...
https://blogs.biomedcentral.com/on-health/2019/09/01/the-new-era-of-disease-modifying-migraine-drugs-dmmds/
Characterization of CGRP protein expression in satellite-like cells and dendritic arbours of the mouse olfactory bulbCharacterization of CGRP protein expression in satellite-like cells and dendritic arbours of the mouse olfactory bulb
The main olfactory bulb (OB) is made up of several concentric layers, forming circuitries often involving dendro-dendritic synapses. Important interactions between OB neurons occur in the external plexiform layer (EPL), where dendrites of tufted and Van Gehuchten cells form synapses with dendrites of deeper lying mitral, tufted, and granule cells. OB neurons display a variety of neurotransmitters. Here, the focus is on calcitonin gene-related peptide (CGRP), a 37-amino acid neuropeptide transmitter that is widely distributed in the central and peripheral nervous system. In the OB, CGRP-immunoreactive (ir) cell bodies were mostly observed in the mitral cell layer (MCL) of normal mice, and their number increased following colchicine treatment. Sparsely distributed CGRP-ir cell bodies were also found in the EPL and granular cell layer. Double-immunofluorescence experiments revealed a lack of co-localization between CGRP-like immunoreactivity (LI) and corticotropin-releasing factor- or galanin-LI, ...
http://uu.diva-portal.org/smash/record.jsf?pid=diva2:317437
CGRP-induced light aversion in a preclinical migraine model - Andrew RussoCGRP-induced light aversion in a preclinical migraine model - Andrew Russo
Migraine is a debilitating neurological condition involving the neuropeptide calcitonin gene-related peptide (CGRP). The overall objective of this project is to...
http://grantome.com/grant/NIH/R01-NS075599-02
Ultra-high field MR angiography in human migraine models: a 3.0 T/7.0 T comparison study | The Journal of Headache and Pain |...Ultra-high field MR angiography in human migraine models: a 3.0 T/7.0 T comparison study | The Journal of Headache and Pain |...
Sildenafil and calcitonin gene-related peptide both dilate the intradural segments of the middle meningeal artery measured with 3.0 tesla (T) MR angiography. Here we hypothesized that an increase in field strength to 7.0 T and concomitant enhanced voxel resolution would lower variance in measurements of dilation in the intradural middle meningeal artery. Five subjects completed two sessions at respectively 3.0 T and 7.0 T. Each session comprised MR angiography scans once before and twice after administration of sildenafil, calcitonin gene-related peptide or placebo in a three-way, crossover, double-blind, placebo-controlled design. Standard deviations of arterial circumference revealed no difference between 3.0 T and 7.0 T measurements (p = 0.379). We found a decrease in standard deviation from our original angiography analysis software (QMra) to a newer (LAVA) software package (p | 0.001). Furthermore, we found that the dilation after sildenafil and calcitonin gene-related peptide were comparable
https://thejournalofheadacheandpain.biomedcentral.com/articles/10.1186/s10194-019-0996-x/figures/1
Critical role of calcitonin gene-related peptide receptors in cortical spreading depression. | Pain Research ForumCritical role of calcitonin gene-related peptide receptors in cortical spreading depression. | Pain Research Forum
Tozzi A, de Iure A, Di Filippo M, Costa C, Caproni S, Pisani A, Bonsi P, Picconi B, Cupini LM, Materazzi S, Geppetti P, Sarchielli P, Calabresi ...
https://www.painresearchforum.org/papers/21403-critical-role-calcitonin-gene-related-peptide-receptors-cortical-spreading-depression
Acupuncture for Relief of Angina | CirculationAcupuncture for Relief of Angina | Circulation
To the Editor: I read with interest the ESBY study (Electrical Stimulation versus coronary artery BYpass surgery in severe angina pectoris) by Mannheimer et al.1 They found that spinal cord stimulation (SCS) has antianginal and anti-ischemic effects in severe angina pectoris and concluded that CABG and SCS are equivalent methods in terms of symptom relief.. In a previous report,2 these authors showed that myocardial extraction of β-endorphin during control atrial pacing changed to release at the maximum pacing rate during SCS. Furthermore, their results indicate local myocardial turnover of β-endorphin, leuenkephalin, and calcitonin-gene-related peptide. Han et al3 found that electroacupuncture of different frequencies was able to activate different opioid systems in the spinal cord of the rat: low frequency (2 Hz) for [Met5 ]enkephalin release and high frequency (100 Hz) for dynorphin A release. An optimal combination of electroacupuncture parameters is now under study for maximal release of ...
http://circ.ahajournals.org/content/98/21/2357a
Role of ATP-sensitive K<sup>+</sup> channels in CGRP-induced dilatation of basilar artery...Role of ATP-sensitive K<sup>+</sup> channels in CGRP-induced dilatation of basilar artery...
TY - JOUR. T1 - Role of ATP-sensitive K+ channels in CGRP-induced dilatation of basilar artery in vivo. AU - Kitazono, Takanari. AU - Heistad, D. D.. AU - Faraci, F. M.. PY - 1993/9/22. Y1 - 1993/9/22. N2 - Stimulation of adenylate cyclase appears to activate ATP-sensitive K+ channels in the basilar artery. We tested the hypothesis that calcitonin gene-related peptide (CGRP), which increases intracellular adenosine 3,5- cyclic monophosphate (cAMP) levels, activates ATP-sensitive K+ channels and thereby causes vasodilatation. Using a cranial window in anesthetized rats, we examined responses of the basilar artery to CGRP in vivo. We also examined responses of the artery to another vasoactive peptide, vasoactive intestinal peptide (VIP). Topical application of CGRP (10-11 to 10-8 M) increased diameter of the basilar artery. Responses of the basilar artery to CGRP were almost abolished by a CGRP1 receptor antagonist, CGRP-(8-37). Vasodilatation in response to VIP was much smaller than that ...
https://kyushu-u.pure.elsevier.com/en/publications/role-of-atp-sensitive-ksupsup-channels-in-cgrp-induced-dilatation
Calcitonin Related PeptidesCalcitonin Related Peptides
Peptides , Calcitonin Related Peptides; Calcitonin gene-related peptide (CGRP), adrenomedullin (ADM) and amylin belong to a unique group of calcitonin-related peptide hormones important for homeostasis in diverse tissues. Calcitonin, a 32-amino acid peptide hormone, is essential for calcium balance, whereas CGRP and ADM are important for neurotransmission and cardiovascular and respiratory function. Calcitonin regulates mineral balance by controlling blood concentrations of calcium and phosphorus metabolism and can cause hypercalcemia. An increase in the serum calcium level is known to stimulate calcitonin secretion. In mammals, the major source of calcitonin is from the parafollicular or C cells in the thyroid gland, but it is also synthesized in a wide variety of other tissues, including the lung and intestinal tract. Calcitonin contains a single disulfide bond, which causes the amino terminus to assume the shape of a ring. The calcitonin family of peptides act through G-protein protein coupled
https://www.anaspec.com/products/productcategory.asp?id=157
Papers with the keyword Gepants | Read by QxMDPapers with the keyword Gepants | Read by QxMD
The trigeminal ganglion plays a key role in primary headache pathophysiology. Calcitonin gene-related peptide (CGRP) and CGRP receptors are expressed in trigeminal neurons that form C-fibers and A-fibers, respectively. In acute migraine and cluster headache attacks, there is release of CGRP into the cranial venous outflow. In addition, intravenous CGRP can induce migraine-like symptoms in migraine patients. These findings led to the development of anti-migraine therapies that inhibit CGRP action. Currently, CGRP receptor antagonists, the gepants, and monoclonal antibodies towards CGRP and the CGRP receptor are all showing positive relief of acute and chronic migraine in clinical trials ...
https://www.readbyqxmd.com/keyword/66658
Aston Publications ExplorerAston Publications Explorer
The calcitonin gene-related peptide (CGRP) receptor is a heterodimer of a family B G-protein-coupled receptor, calcitonin receptor-like receptor (CLR), and the accessory protein receptor activity modifying protein 1. It couples to Gs, but it is not known which intracellular loops mediate this. We have identified the boundaries of this loop based on the relative position and length of the juxtamembrane transmembrane regions 3 and 4. The loop has been analyzed by systematic mutagenesis of all residues to alanine, measuring cAMP accumulation, CGRP affinity, and receptor expression. Unlike rhodopsin, ICL2 of the CGRP receptor plays a part in the conformational switch after agonist interaction. His-216 and Lys-227 were essential for a functional CGRP-induced cAMP response. The effect of (H216A)CLR is due to a disruption to the cell surface transport or surface stability of the mutant receptor. In contrast, (K227A)CLR had wild-type expression and agonist affinity, suggesting a direct disruption to the ...
http://publications.aston.ac.uk/13/
Inhibition of inflammatory pain by activating B-type natriuretic peptide signal pathway in nociceptive sensory neurons | Read...Inhibition of inflammatory pain by activating B-type natriuretic peptide signal pathway in nociceptive sensory neurons | Read...
B-type natriuretic peptide (BNP) has been known to be secreted from cardiac myocytes and activate its receptor, natriuretic peptide receptor-A (NPR-A), to reduce ventricular fibrosis. However, the function of BNP/NPR-A pathway in the somatic sensory system has been unknown. In the present study, we report a novel function of BNP in pain modulation. Using microarray and immunoblot analyses, we found that BNP and NPR-A were expressed in the dorsal root ganglion (DRG) of rats and upregulated after intraplantar injection of complete Freunds adjuvant (CFA). Immunohistochemistry showed that BNP was expressed in calcitonin gene-related peptide (CGRP)-containing small neurons and IB4 (isolectin B4)-positive neurons, whereas NPR-A was present in CGRP-containing neurons. Application of BNP reduced the firing frequency of small DRG neurons in the presence of glutamate through opening large-conductance Ca2+-activated K+ channels (BKCa channels). Furthermore, intrathecal injection of BNP yielded inhibitory ...
https://read.qxmd.com/read/20702721/inhibition-of-inflammatory-pain-by-activating-b-type-natriuretic-peptide-signal-pathway-in-nociceptive-sensory-neurons
IJMS | Free Full-Text | Novel Potentials of the DPP-4 Inhibitor Sitagliptin against Ischemia-Reperfusion (I/R) Injury in Rat...IJMS | Free Full-Text | Novel Potentials of the DPP-4 Inhibitor Sitagliptin against Ischemia-Reperfusion (I/R) Injury in Rat...
Dipeptidyl peptidase-4 (DPP-4) inhibitors are a class of oral anti-diabetic drugs, implicated in pleiotropic secondary cardioprotective effects. The aim of the study was to unveil the unknown and possible cardioprotective targets that can be exerted by sitagliptin (Sitg) against ischemia-reperfusion (I/R) injury. Male wistar rats received 2 weeks’ Sitg oral treatment of different doses (25, 50, 100, and 150 mg/kg/day), or saline as a Control. Hearts were then isolated and subjected to two different I/R injury protocols: 10 min perfusion, 45 min regional ischemia, and 120 min reperfusion for infarct size (IS) measurement, or: 10 min perfusion, 45 min regional ischemia and 10 min reperfusion for biochemical analysis: nitric oxide synthases (NOSs) and DPP-4 activity, glucagon-like peptide-1 (GLP-1), Calcium, transient receptor potential vanilloid (TRPV)-1 and calcitonin gene-related peptide (CGRP) levels, transient receptor potential canonical (TRPC)-1 and e-NOS protein expression. NOS inhibitor (l
https://www.mdpi.com/1422-0067/19/10/3226/htm
Further studies on the mode of action of calcitonin on isolated rat osteoclasts: pharmacological evidence for a second site...Further studies on the mode of action of calcitonin on isolated rat osteoclasts: pharmacological evidence for a second site...
Calcitonin is a circulating polypeptide that inhibits bone resorption by inducing both quiescence (Q effect) and retraction (R effect) in osteoclasts. Two structurally related members of the calcitonin gene peptide family, calcitonin gene-related peptide (CGRP) and amylin, inhibit osteoclastic bone resorption selectively via the Q effect. In the present study, we have made measurements of cell spread area in response to the application of amylin, CGRP and a peptide fragment of CGRP, CGRP-(Val8Phe37). We found that, over a wide concentration range (50 pmol/l to 2.5 mumol/l), the selective Q effect agonists did not produce an R effect. Furthermore, the peptides, when used at a 50-fold higher molar concentration than calcitonin, did not antagonize calcitonin-induced cell retraction. Additionally, experiments designed to measure changes in the intracellular free calcium concentration ([Ca2+]i) in single osteoclasts revealed that, unlike calcitonin, the non-calcitonin Q effect agonists did not produce a rise
https://www.ndorms.ox.ac.uk/publications/475698
Calcitonin gene-related peptide antagonism and cluster headache: an emerging new treatment. | Pain Research ForumCalcitonin gene-related peptide antagonism and cluster headache: an emerging new treatment. | Pain Research Forum
PRF readers can get free access to a selected Journal of Pain paper each month, thanks to the American Pain Society. Get the free full text of the selection from the December 2017 issue here.. ...
http://painresearchforum.org/papers/85665-calcitonin-gene-related-peptide-antagonism-and-cluster-headache-emerging-new-treatment
Yeni ÇIKAN ELISA KitleriYeni ÇIKAN ELISA Kitleri
Human APP PicoKine™ ELISA Kit (Amyloid beta A4 protein)...: cell biology- apoptosis- neural signal transduction- nervous system development. Bazı Hormon Belirteçleri için Yeni Çıkan ELISA Kitleri: -Alpha (aCGRP) Calcitonin Gene-Related Peptide ELISA Kit. -Beta(bCGRP) Calcitonin Gene-Related Peptide ELISA Kit. -Bradykinin ELISA Kit. -Caerulein ELISA Kit. -Dynorphin ELISA Kit. -ELABELA ELISA kit. -Enkephalin ELISA Kit. -Exendin-4 ELISA Kit. -Galanin ELISA Kit. -Hepsidin 25 ELISA Kit. -LHRH ELISA Kit. -Liraglutide ELISA Kit. -Pancreastatin ELISA Kit. -Secretin ELISA Kit. -TIP39(Tuberoinfundibular peptide39) ELISA Kit. -VIF ( Vasoconstriction Inhibiting Factor) ELISA Kit -VIP ( Vasoactive Interstinal Peptide) ELISA Kit Yeni ÇIKAN ELISA Kitleri ve Klinik Eşleştirmeleri: *Human Afamin ELISA kit: AFM is a member of the albumin gene family: Diabetology - Other Relevant Products, Energy metabolism and body weight regulation. *Human Cystatin B ELISA: Autoimmunity, Oncolog. *Human Cysteine-Rich ...
http://www.biocersaglik.com/duyurular-yeni-cikan-elisa-kitleri_5
Calcitonin Gene-related Peptide Levels in Chronic Migraine - Full Text View - ClinicalTrials.govCalcitonin Gene-related Peptide Levels in Chronic Migraine - Full Text View - ClinicalTrials.gov
A female is considered of childbearing potential unless she is post menopausal for at least 12 months prior to administration of study drug, without a uterus and/or both ovaries or has been surgically sterilized for at least 6 months prior to study drug administration.. Reliable methods of contraception are: Complete abstinence from intercourse from 2 weeks prior to administration of the investigational product, throughout the study, and for a time interval (5 days) after completion or premature discontinuation from the study; or, History of bilateral tubal ligation; or, Sterilization of male partner; or, Implants of levonorgestrel; or, Injectable progestogen; or, Oral contraceptive (combination therapy with ethinyl estradiol plus a progestin) with a placebo week every 1-3 months; or, Any intrauterine device (IUD) with published data showing that the highest expected failure rate is less than 1% per year (not all IUDs meet this criterion) in use at least 30 days prior to study drug ...
https://www.clinicaltrials.gov/ct2/show/NCT01071096
İleri evre küçük hücreli dışı akciğer kanserli hastalarda serum vasküler endoteliyal büyüme faktörü, endotelin-1 ve alfa...İleri evre küçük hücreli dışı akciğer kanserli hastalarda serum vasküler endoteliyal büyüme faktörü, endotelin-1 ve alfa...
Due to a dismal prognosis of advanced non- small cell lung cancer (NSCLC), novel screening tools and more effective treatments are clearly needed. Vascular endothelial growth factor (VEGF) is the most important angiogenic factor. Endothelin-1 (ET-1) and alpha calcitonin gene related peptides (CGRP) are promising biomarkers for tumor angiogenesis. The aims of our study were to evaluate angiogenic and prognostic impacts of VEGF, ET-1, CGRP and other laboratory parameters? serum levels in advanced NSCLC patients. Sixty seven patiens (62 male, 5 female) and twenty healhty (16 male, 4 female) volunteers were included in this study. Demographical, laboratory data and serum levels of VEGF, ET-1 and CGRP were compared for two groups. Patients presented significantly higher serum VEGF (p=0.000), lower serum thyroid stimulating hormone (TSH), albumin and hemoglobin levels than controls (p=0.000, p=0.014 and p=0.001 respectively). Leukocytosis, thrombocytosis, high levels of C reactive peptide (CRP) and ...
http://acikerisim.pau.edu.tr:8080/xmlui/handle/11499/2643
Up-regulation of substance P in low-threshold myelinated afferents is not required for tactile allodynia in the chronic...Up-regulation of substance P in low-threshold myelinated afferents is not required for tactile allodynia in the chronic...
It has been proposed that substance P and calcitonin gene-related peptide (CGRP) are up-regulated in low-threshold myelinated primary afferents following certain types of nerve injury, and that release of substance P from these afferents contributes to the resulting tactile allodynia. To test this hypothesis, we looked for neuropeptides in Aβ primary afferent terminals in the ipsilateral gracile nucleus and spinal dorsal horn in three nerve injury models: sciatic nerve transection (SNT), spinal nerve ligation (SNL) and chronic constriction injury (CCI). We also looked for evidence of neurokinin 1 (NK1) receptor internalisation in the dorsal horn following electrical stimulation of Aβ afferents. We found no evidence of either substance P or CGRP expression in injured Aβ terminals in the spinal cord in any of the models. Although substance P was not detected in terminals of injured afferents in the gracile nucleus, CGRP was expressed in between 32 and 68% of these terminals, with a ...
http://eprints.gla.ac.uk/4753/
Upregulation of substance P in low-threshold myelinated afferents is not required for tactile allodynia in the chronic...Upregulation of substance P in low-threshold myelinated afferents is not required for tactile allodynia in the chronic...
It has been proposed that substance P and calcitonin gene-related peptide (CGRP) are upregulated in low-threshold myelinated primary afferents after certain types of nerve injury, and that release of substance P from these afferents contributes to the resulting tactile allodynia. To test this hypothesis, we looked for neuropeptides in Aβ primary afferent terminals in the ipsilateral gracile nucleus and spinal dorsal horn in three nerve injury models: sciatic nerve transection (SNT), spinal nerve ligation (SNL), and chronic constriction injury (CCI). We also looked for evidence of neurokinin 1 (NK1) receptor internalization in the dorsal horn after electrical stimulation of Aβ afferents. We found no evidence of either substance P or CGRP expression in injured Aβ terminals in the spinal cord in any of the models. Although substance P was not detected in terminals of injured afferents in the gracile nucleus, CGRP was expressed in between 32 and 68% of these terminals, with a significantly higher ...
http://eprints.gla.ac.uk/9749/
CGRP antibodies & migraine - findings so far - MigraineCGRP antibodies & migraine - findings so far - Migraine
CGRP (Calcitonin Gene Related Peptide) is a neuropeptide which is released into the blood stream during a migraine attack and it has a central role in the underlying mechanisms of a migraine attack.. Recent results from clinical trials targeting CGRP are encouraging and the drugs are now entering phase 3 late stage clinical trials to further evaluate the benefits and safety of these new therapies.. In this video clip at the European Academy of Neurology Congress 2016, Prof. Peter Goadsby discusses the rationale for using CGRP antibodies in the treatment of migraine and the study findings so far ...
https://www.migraine.ie/cgrp-antibodies-migraine-findings-so-far/
Plus itPlus it
Calcitonin gene-related peptide (CGRP) receptors were solubilized from rat cerebellum membranes in an active, stable, and guanine nucleotide-sensitive form by using digitonin. Nearly 90% of membrane CGRP receptors and 50% of membrane protein were solubilized by digitonin treatment of cerebellum membranes. Binding of 125ICGRP to soluble receptors was specific, saturable, of high affinity, and reversible. Scatchard analysis of the saturation binding data revealed a homogeneous population of binding sites with a Kd of 178 +/- 42 pM and a Bmax of 201 +/- 17 fmol/mg of protein. Binding of 125ICGRP to soluble receptors was inhibited nearly 60% by guanosine-5-O-(3-thio)triphosphate (GTP gamma S) (100 microM), suggesting coupling of receptors with guanine nucleotide-binding proteins (G proteins) to form high affinity binding sites. Antiserum against the amino-terminal region of Gs alpha immunoprecipitated a significant portion of soluble CGRP receptors, indicating association of receptors with Gs ...
http://molpharm.aspetjournals.org/content/43/2/167
Prostaglandin E<sub>2</sub> enhances bradykinin-stimulated release of neuropeptides from rat sensory neurons in...Prostaglandin E<sub>2</sub> enhances bradykinin-stimulated release of neuropeptides from rat sensory neurons in...
TY - JOUR. T1 - Prostaglandin E2 enhances bradykinin-stimulated release of neuropeptides from rat sensory neurons in culture. AU - Vasko, M. R.. AU - Campbell, W. B.. AU - Waite, K. J.. PY - 1994/8/1. Y1 - 1994/8/1. N2 - Prostaglandins are known to enhance the inflammatory and nociceptive actions of other chemical mediators of inflammation such as bradykinin. One possible mechanism for this sensitizing action is that prostanoids augment the release of neuroactive substances from sensory neurons. To initially test this hypothesis, we examined whether selected prostaglandins could enhance the resting or bradykinin-evoked release of immunoreactive substance P (iSP) and/or immunoreactive calcitonin gene-related peptide (iCGRP) from sensory neurons in culture. Bradykinin alone causes a concentration-dependent increase in the release of iSP and iCGRP from isolated sensory neurons, and this action is abolished in the absence of extracellular calcium. Pretreating the neurons with PGE2 (10 nM to 1 μM) ...
https://indiana.pure.elsevier.com/en/publications/prostaglandin-esub2sub-enhances-bradykinin-stimulated-release-of-
Vasodilator nerve legal definition of vasodilator nerveVasodilator nerve legal definition of vasodilator nerve
Definition of vasodilator nerve in the Legal Dictionary - by Free online English dictionary and encyclopedia. What is vasodilator nerve? Meaning of vasodilator nerve as a legal term. What does vasodilator nerve mean in law?
http://legal-dictionary.thefreedictionary.com/vasodilator+nerve
Repositorio da Producao Cientifica e Intelectual da Unicamp: Early potential impairment of renal sensory nerves in...Repositorio da Producao Cientifica e Intelectual da Unicamp: Early potential impairment of renal sensory nerves in...
Background. Electrophysiological studies in the mammalian kidney have identified two major classes of sensory receptors of the afferent renal nerves; chemoreceptors (CR) and mechanoreceptors (MR). The localization of calcitonin gene-related peptide (CGRP) and substance P (SP) in these renal pelvic sensory neurons provides an anatomical basis for a possible functional interaction between the two neuropeptides and SP receptor. The present study was performed to examine the possible changes in the responsiveness of renal sensory SP and CGRP receptors in rats with streptozotocin (STZ)-induced diabetes mellitus. Due to the crucial role of renal pelvic SP and CGRP receptors in the activation of renal sensory neurons by various stimuli, we examined whether the responsiveness of MR or CR activation and the dorsal root ganglia content of neuropeptides and neurokinin 1 receptors (NK(1)R) were altered in diabetic rats compared with non-diabetic rats. Methods. Afferent renal nerve activity (ARNA) was ...
http://repositorio.unicamp.br/jspui/handle/REPOSIP/63634
Migraine: A Neuroinflammatory Disease? - Egilius L. H. Spierings; M.Sanchez del Rio; | Foyles BookstoreMigraine: A Neuroinflammatory Disease? - Egilius L. H. Spierings; M.Sanchez del Rio; | Foyles Bookstore
This book contains reviews by a renowned group of clinicians and scientists, which consider in great depth the potential involvement of neurogenic inflammation in the pathogenesis of migraine and inhibition of this putative mechanism as a possible mode of action of antimigraine medications. The authors carefully consider current and future potential therapeutic approaches for the abortive as well as preventive treatment of migraine. The pioneering work by Professor Michael A. Moskowitzs group at Harvard gave rise to the neurogenic hypothesis of migraine pathogenesis and to an intel- lectual framework for many aspects of migraine research through a detailed phar- macological characterization of the trigeminovascular system. This knowledge then spurred detailed research worldwide into the roles of the dural vasculature, trigem- inal nerve fibers, and sensory neuropeptides, such as substance P and calcitonin gene-related peptide, in migraine. Similar in-depth investigations have not been made of the
http://www.foyles.co.uk/witem/medical-veterinary/migraine-a-neuroinflammatory-disease,egilius-l-h-spierings-msanchez-9783764362317
New players in the preventive treatment of migraine.New players in the preventive treatment of migraine.
Author(s): Mitsikostas, Dimos D; Rapoport, Alan M | Abstract: Migraine is a common, chronic disorder of the brain causing much disability, as well as personal, familial and societal impact. Several oral preventive agents are available in different countries for the prevention of migraine, but none have performed better than 50% improvement in 50% of patients in a clinical trial. Additionally, each has various possible adverse events making their tolerability less than optimal. Recently, three monoclonal antibodies targeting the calcitonin gene-related peptide (CGRP) ligand (LY2951742, ALD403 and TEV-48125) and one targeting the CGRP receptor (AMG 334) have completed phase 2 trials, and the results have been reported. These early results show them all to be somewhat more effective than placebo, with no serious adverse events. Three have been studied for episodic migraine, and only TEV-48125 has been studied for both high frequency episodic and chronic migraine. Moreover, preliminary data suggests that
https://escholarship.org/uc/item/01d1z6p8
Olcegepant - DrugBankOlcegepant - DrugBank
Boehringer Ingelheim Pharmaceuticals olcegepant (BIBN 4096) is a selective Calcitonin Gene-Related Peptide (CGRP) antagonist, a new class of drugs in development for the treatment of acute migraine attacks. Olcegepant is undergoing phase II trials in Europe and the US, with preliminary results suggesting that CGRP antagonists may represent a potential new approach to the treatment of migraine.
https://www.drugbank.ca/drugs/DB04869
Citation tools | Neurology Clinical PracticeCitation tools | Neurology Clinical Practice
Goldstein, Eric D., Mohammed K. Badi, and James F. Meschia. Treating chronic migraine in CADASIL with calcitonin gene-related peptide receptor antagonism. Neurology: Clinical Practice (2019): 10.1212/CPJ.0000000000000651. Web. 20 Sept2020. ...
https://cp.neurology.org/highwire/citation/10886/download
Sensory nerves in the interface membrane of aseptic loose hip prosthesesSensory nerves in the interface membrane of aseptic loose hip prostheses
We studied the presence of sensory nerves by immunohistochemistry in the interface membranes of hip prostheses after aseptic loosening. Substance P (SP), neurokinin A (NKA) and calcitonin gene-related peptide (CGRP) were analysed as was protein gene product (PGP) 9.5, a general marker for nerve fibr …
https://pubmed.ncbi.nlm.nih.gov/9460973/?dopt=Abstract
Neuromics: Arthritic Pain, Nerve Sprouting and Neuroma FormationNeuromics: Arthritic Pain, Nerve Sprouting and Neuroma Formation
Images. Sensory nerve fiber sprouting and formation of neuroma-like structures in the painful geriatric arthritic knee joint. Schematic of a frontal view of a cross-sectioned mouse knee joint (A). The red square illustrates the synovial region from which the confocal images were obtained. Representative confocal images of calcitonin gene-related peptide (CGRP+), neurofilament 200 kDa (NF200+) sensory nerve fibers (yellow/orange) and growth associated protein (GAP43; marker of fibers undergo regeneration, yellow/orange) and DAPI labeled nuclei (blue) in knee joint sections (20 μm thick) of vehicle-injected (B,D,F) and CFA-injected (C,E,G ) mice. In vehicle-injected mice, a low level, regular pattern of innervation by CGRP+ and NF200+ fibers is observed in the synovial space of the knee joint. Twenty-eight days following the initial CFA injection, a significant number of CGRP+ and NF200+ nerve fibers have sprouted and have a disorganized appearance as compared to vehicle-injected mice. Note that, ...
http://neuromics.blogspot.com/2012/05/arthritic-pain-nerve-sprouting-and.html
CGRP Inhibitors for Migraines: Aimovig, Ajovy, Vyepti, and EmgalityCGRP Inhibitors for Migraines: Aimovig, Ajovy, Vyepti, and Emgality
Learn about Aimovig, Ajovy, Vyepti, Emgality, and Nurtec - medications called calcitonin gene-related peptide (CGRP) inhibitors for preventing chronic and episodic migraines.
https://www.verywellhealth.com/cgrp-inhibitors-prevent-migraines-1719843
Neuromics: May 2012Neuromics: May 2012
Images. Sensory nerve fiber sprouting and formation of neuroma-like structures in the painful geriatric arthritic knee joint. Schematic of a frontal view of a cross-sectioned mouse knee joint (A). The red square illustrates the synovial region from which the confocal images were obtained. Representative confocal images of calcitonin gene-related peptide (CGRP+), neurofilament 200 kDa (NF200+) sensory nerve fibers (yellow/orange) and growth associated protein (GAP43; marker of fibers undergo regeneration, yellow/orange) and DAPI labeled nuclei (blue) in knee joint sections (20 μm thick) of vehicle-injected (B,D,F) and CFA-injected (C,E,G ) mice. In vehicle-injected mice, a low level, regular pattern of innervation by CGRP+ and NF200+ fibers is observed in the synovial space of the knee joint. Twenty-eight days following the initial CFA injection, a significant number of CGRP+ and NF200+ nerve fibers have sprouted and have a disorganized appearance as compared to vehicle-injected mice. Note that, ...
http://neuromics.blogspot.com/2012/05/
INT48758 - wiki-painINT48758 - wiki-pain
Dorsal root ganglia taken from animals with CCI were analyzed for alterations in mRNA levels encoding growth-associated protein-43 (GAP-43), calcitonin gene-related peptide (CGRP), galanin (GAL), neuropeptide Y (NPY), substance P (SP), and vasoactive intestinal polypeptide (VIP ...
http://gnteam.cs.manchester.ac.uk/demos/wiki-pain/vhosts/wikipaints/mediawiki-1.19.1/index.php/INT48758
Little Pharmacy: Viagra side effects on teenagers pills available!Little Pharmacy: Viagra side effects on teenagers pills available!
As hartmann and waldinger offer a useful adjunct for almost 3 years. Intracavernous calcitonin gene-related peptide (cgrp) acts on the male and his colleagues (1945) seemed willing to trust either my health or mental state and depression problems. The philosopher aristotle (384382 b. C.. Figure 5 graphic representation of the specific needs of these cases. I probably had cfs (chronic fatigue syndrome) from puberty although this may indicate a need for invasive treatment; however, when the patient presented with a male patient may present days or undergo surgical insertion of a sense of obligation that once impotent, always impotent, as some degree or existence of this disorder (jannini & lenzi, 2003; laumann et al. If our hypothesis is another term used for examining deep structures by means of self-protection, protection of the case the blending of mind and the duration and origin of the. He and cathy saw a woman is expected to be a sign of caring while she has power in the literature ...
http://hyperbaricnurses.org/16574-viagra-side-effects-on-teenagers/
ORBi: Browsing ORBiORBi: Browsing ORBi
in Neuroscience (1992), 51(2), 401-10. In a previous work we have shown that culturing adult rat dorsal root ganglia neurons modifies their neurotransmitter phenotype in such a way that cultured neurons synthesize transmitters that are not ... [more ▼]. In a previous work we have shown that culturing adult rat dorsal root ganglia neurons modifies their neurotransmitter phenotype in such a way that cultured neurons synthesize transmitters that are not found in situ, while several other transmitters are expressed in a much higher percentage of neurons in culture than in situ [Schoenen J. et al. (1989) J. Neurosci. Res. 22, 473-487]. The aim of the present study was to investigate the origin and the nature of the relevant environmental signals that allow this plasticity to be expressed, focusing on three neurotransmitters: 5-hydroxytryptamine, thyrotropin-releasing hormone and calcitonin-gene related peptide. The main results can be summarized as follows: (1) culturing cells in fetal calf serum ...
http://orbi.ulg.ac.be/browse?type=author&sort_by=1&order=DESC&rpp=20&etal=3&value=Leprince%2C+Pierre+p001309&offset=100
Expression and distribution of the transient receptor potential cationic channel ankyrin 1 (TRPA1) in the human vaginaExpression and distribution of the transient receptor potential cationic channel ankyrin 1 (TRPA1) in the human vagina
The transient receptor potential cationic channel type A1 (TRPA1), belonging to a superfamily of cationic membrane channels, has been suggested to act as mechano- and pain sensor and, thus, to play a role in neurotransmission in the human body, including the urogenital tract While the expression of TRPA1 has been investigated in a variety of tissues, up until today no Study has addressed the expression and distribution in the female genital tract. The present study aimed to investigate the expression and distribution of TRPA1 protein in human vaginal tissue, Reverse transcriptase PCR (RT-PCR) Was applied in order to identify messenger ribonuleic acid specifically encoding for TAPA/A1. The distribution of TRPA1 in relation to the neuronal nitric oxide synthase (nNOS) and the signaling peptide calcitonin gene-related peptide (CGRP) was examined by means of imnnunohistocheitical methods (double-antibody technique, laser fluorescence microscopy). RT-PCR analysis revealed the expression of mRNA ...
http://liu.diva-portal.org/smash/record.jsf?pid=diva2:791927
Heterotopic Ossification Has Some Nerve - Critical Reviews™ in Eukaryotic Gene Expression, 巻 20, 2010, 発行 4 - Begell House...Heterotopic Ossification Has Some Nerve - Critical Reviews™ in Eukaryotic Gene Expression, 巻 20, 2010, 発行 4 - Begell House...
Heterotopic ossification, defined as the formation of bone in abnormal anatomic locations, can be clinically insignificant or devastating and debilitating, depending on the site and duration of new bone formation. There are many causes of heterotopic ossification (HO), including soft tissue trauma, central nervous system injury, vasculopathies, arthropathies, and inheritance. One of the least understood components of HO is the interaction of the peripheral nervous system with the induction of this process. Recent work has shown that, upon traumatic injury, a cascade of events termed neurogenic inflammation is initiated, which involves the release of neuropeptides, such as substance P and calcitonin gene related peptide. Release of these peptides ultimately leads to the recruitment of activated platelets, mast cells, and neutrophils to the injury site. These cells appear to be involved with both remodeling of the nerve, as well as potentially recruiting additional cells from the bone marrow to ...
http://dl.begellhouse.com/jp/journals/6dbf508d3b17c437,236270b917b07d7f,7da12e55535a5e10.html
Antibodies bode well for migraines | Headache NewsBlogAntibodies bode well for migraines | Headache NewsBlog
Antibodies blocking a specific neurotransmitter involved in migraines appear to relieve migraine headaches. Two studies presented at the annual meeting of the American Academy of Neurology reported on the use of antibodies to CGRP (calcitonin gene-related peptide) for the treatment of migraine headaches. These were relatively small, but highly scientific (randomized, double-blind, and placebo-controlled) studies.…
http://www.nyheadache.com/blog/antibodies-bode-well-for-migraines/
The Role of Neuropeptides and Neurohormones in Neurogenic Cardiac Arrhythmias | Bentham ScienceThe Role of Neuropeptides and Neurohormones in Neurogenic Cardiac Arrhythmias | Bentham Science
Title: The Role of Neuropeptides and Neurohormones in Neurogenic Cardiac Arrhythmias. VOLUME: 3 ISSUE: 3. Author(s):T. M. Saleh. Affiliation:Department of Biomedical Science, Atlantic Veterinary College, University of Prince Edward Island,Charlottetown, P.E.I., Canada, C1A 4P3.. Keywords:neurotensin, substance p, cholecystokinin, somatostatin, calcitonin gene-related peptide, estrogen, sympathetic, parasympathetic, baroreceptor reflex, arrhythmias. Abstract: The functional significance of neuropeptides and neurohormones throughout the neuroaxis has been the focus of considerable research over the past 25 years. These gut peptides or reproductive hormones have been localized within nuclei responsible for the relay of visceral afferent information to the forebrain. The presence of peptides and hormones along the gut- or heart-brain continuum suggests that these neurochemicals do more than modulate the visceral processes of digestion and reproduction respectively. Numerous studies have shown ...
https://www.eurekaselect.com/91587/article/role-neuropeptides-and-neurohormones-neurogenic-cardiac-arrhythmias?tracking-code=4
Analysts offer a lukewarm endorsement to Amgen for PhIII migraine data; Arsanis raises $45.5M Series D; Covance faces...Analysts offer a lukewarm endorsement to Amgen for PhIII migraine data; Arsanis raises $45.5M Series D; Covance faces...
Analysts took a look at the data on Amgens latest Phase III for CGRP migraine drug erenumab (AMG334) and came away reassured, but perhaps a bit unimpressed. Heres Leerinks Geoffrey Porges: The data confirm the ample evidence from phase 2 trials that suggested that calcitonin gene-related peptide (CGRP) receptor blockade will provide the first-ever migraine targeted prevention pharmaceutical treatment. Both trials demonstrated the superiority of AMG334 to placebo on both the primary and secondary endpoints, as well as showing excellent safety and tolerability. While the data were not overwhelmingly positive (i.e., 60% of patients with 50% reduction in migraine days), they were consistent and durable, which should ensure widespread adoption by patients (provide pricing and payer processing allow it). Amgens erenumab appears to have shown a similar placebo adjusted effect as Alders (OP) Eptinezumab in phase 2 trials (1 day improvement of monthly migraines at week 12). The effect is lower than ...
https://endpts.com/analysts-offer-a-lukewarm-endorsement-to-amgen-for-phiii-migraine-data-arsanis-raises-45-5m-series-d-covance-faces-restructuring/
Molecular and functional characterization of amylin, a peptide associated with type 2 diabetes mellitus. - ImmunologyMolecular and functional characterization of amylin, a peptide associated with type 2 diabetes mellitus. - Immunology
The 37-amino acid peptide called amylin is a major component of the islet amyloid deposited in the pancreases of persons with type 2 diabetes mellitus. We report the isolation of a partial cDNA clone and a phage lambda genomic clone of the coding region of the amylin gene. The DNA sequence encodes a protein sequence identical to that of amylin isolated from the amyloid found in the diabetic pancreas and shows that amylin is likely to be synthesized as a precursor peptide, now named proamylin. We have demonstrated that the amylin gene is present on chromosome 12 and that it is probably transcribed in the islets of Langerhans. The sequences of the genes for amylin and the calcitonin gene-related peptides (CGRPs) show strong similarity, especially over their 5 coding regions, where both peptides have a conserved intramolecular disulfide bridge, and also over their 3 coding regions, where the presence of a glycine codon strongly suggests that the carboxyl-terminal residue of amylin, like that of CGRP, is
https://www.immunology.ox.ac.uk/publications/653137
Cyclophosphamide- (CYP-) induced cystitis increases cal | Open-iCyclophosphamide- (CYP-) induced cystitis increases cal | Open-i
Cyclophosphamide- (CYP-) induced cystitis increases calcitonin gene-related peptide (CGRP) in the urinary bladder and cystometric fluid and the antioxidant, Tem
https://openi.nlm.nih.gov/detailedresult.php?img=PMC4417973_TSWJ2015-545048.003&req=4
MEDLINE - Resultado p gina 1MEDLINE - Resultado p gina 1
BACKGROUND: Migraine has been recognized as one of the leading causes of disability in the 2013 Global Burden of Disease Study and seriously affects the quality of patients life, current treatment options are not ideal. Monoclonal antibodies to calcitonin gene-related peptide and its receptor (CGRP-mAbs) appear more promising for migraine because of considerably better effect and safety profiles. The objective of this study is to systematically assess the clinical efficacy and safety of CGRP-mAbs for migraine therapy. METHODS: A systematic literature search in PubMed, Cochrane Library and Baidu Scholar was performed to identify randomized controlled trials (RCTs), which compared the effect and safety of CGRP-mAbs with placebo on migraine. Regarding the efficacy, the reduction of monthly migraine days from baseline to weeks 1-4, 5-8, and 9-12; responder rates were extracted as the outcome measures of the effects of CGRP-mAbs. Regarding the safety, total adverse events, the main adverse events, ...
http://bases.bireme.br/cgi-bin/wxislind.exe/iah/online/?IsisScript=iah/iah.xis&nextAction=lnk&base=MEDLINE&lang=p&format=detailed.pft&indexSearch=EX&exprSearch=D12.776.543.750.695.105
Synaptic Structural Modification Following Changes in Activity Induced by David González-Forero, Angel M. Pastor et al.Synaptic Structural Modification Following Changes in Activity Induced by David González-Forero, Angel M. Pastor et al.
A low or a high dose of tetanus neurotoxin (TeNT) injected in the lateral rectus muscle of the cat causes respectively, functional block of inhibitory synapses only or of both inhibitory and excitatory synapses simultaneously in abducens neurons (González-Forero et al. [2003] J. Neurophysiol. 89:1878-1890). As a consequence, neuronal firing activity increases (at low dose) or decreases (at high dose). We investigated possible structural modifications of inhibitory synapses in response to these activity alterations induced by TeNT. We used immunofluorescence against postsynaptic (gephyrin) and presynaptic (vesicular γ-aminobutyric acid [GABA] transporter [VGAT]) markers of inhibitory synapses in combination with cell type markers for abducens motoneurons (calcitonin gene-related peptide or choline acetyltransferase) or internuclear neurons (calretinin). Seven days after high-dose treatment, the number of gephyrin-immunoreactive (IR) clusters per 100 μm of membrane perimeter was reduced on the soma of
https://corescholar.libraries.wright.edu/ncbp/567/
Pa cv engl.docPa cv engl.doc
electromechanical responses of cardiomyocytes to individual and combined components of ischemia. Can. J. Physiol. Pharmacol, 80: 1145-1157 2003.- Schaeffer, C., D. Vandroux, L. Thomassin, P. Athias, L. Rochette and J. L. Connat. Calcitonin gene-related peptide partly protects cultured smooth muscle cells from apoptosis induced by an oxidative stress via activation of ERK1/2 MAPK. Biochim Biophys Acta 1643(1-3): 65-73. 2004.- Chantome, A., A. Pance, N. Gauthier, D. Vandroux, J. Chenu, E. Solary, J. F. Jeannin and S. Reveneau. Casein kinase II-mediated phosphorylation of NF-kB p65 subunit enhances inducible nitric oxide synthase gene transcription in vivo. J Biol Chem. 279(23): 23953-60. 2004.- Gambert, S., S. Bes-Houtmann, D. Vandroux, C. Tissier, C. Vergely-Vandriesse, L. Rochette and P. Athias. Deep hypothermia during ischemia improves functional recovery and reduces free-radical generation in isolated reperfused rat heart. J Heart Lung Transplant 23(4): 487-91. 2004.- Vandroux, D., C. ...
http://finder-articles.com/p/pathias21.fr1.html
EptinezumabEptinezumab
November 2014). "Safety and efficacy of ALD403, an antibody to calcitonin gene-related peptide, for the prevention of frequent ... Other anti-migraine antibodies blocking the calcitonin gene-related peptide (CGRP) pathway *Erenumab ... It is a monoclonal antibody that targets calcitonin gene-related peptides (CGRP) alpha and beta.[3][4] It is administered by ... This analgesic-related article is a stub. You can help Wikipedia by expanding it. ...
https://en.wikipedia.org/wiki/Eptinezumab
S100A12S100A12
Maayan C, Becker Y, Gesundheit B, Girgis SI (2002). "Calcitonin gene related peptide in familial dysautonomia". Neuropeptides. ... April 1996). "Human CAAF1 gene--molecular cloning, gene structure, and chromosome mapping". Biochemical and Biophysical ... gene, a new member of the S100 gene cluster on chromosome 1q21". Cell Calcium. 20 (6): 459-64. doi:10.1016/S0143-4160(96)90087- ... gene, a new member of the S100 gene cluster on chromosome 1q21". Cell Calcium. 20 (6): 459-64. doi:10.1016/S0143-4160(96)90087- ...
https://en.wikipedia.org/wiki/S100A12
Susan BrainSusan Brain
Brain, S. D.; Williams, T. J.; Tippins, J. R.; Morris, H. R.; MacIntyre, I. (1985). "Calcitonin gene-related peptide is a ... In her early career she discovered the Calcitonin gene-related peptide receptor antagonist (CGRP) as a potent microvascular ... More recently her research found that the gene TRPC5 can help protect against pain in arthritis and that the gene TRPA1 is ...
https://en.wikipedia.org/wiki/Susan_Brain
NeurotransmissionNeurotransmission
ACh-vasoactive intestinal peptide (VIP) co-release. ACh-calcitonin gene-related peptide (CGRP) co-release. Glutamate-dynorphin ... For example, striatal "GABAergic neurons" utilize opioid peptides or substance P as their primary cotransmitter. Some neurons ...
https://en.wikipedia.org/wiki/Neurotransmission
CALCRLCALCRL
... it is a receptor for calcitonin gene-related peptide. The protein encoded by the CALCRL gene is a G protein-coupled receptor ... 2004). "Calcitonin gene-related peptide and its role in migraine pathophysiology". Eur J Pharmacol. 500 (1-3): 315-30. doi: ... Calcitonin gene-related peptide receptor antagonists are approved for the treatment of migraine. GRCh38: Ensembl release 89: ... 2003). "Calcitonin gene-related peptide in pregnancy and its emerging receptor heterogeneity". Trends Endocrinol. Metab. 13 (6 ...
https://en.wikipedia.org/wiki/CALCRL
MigraineMigraine
Calcitonin gene related peptides (CGRPs) have been found to play a role in the pathogenesis of the pain associated with ... CGRP receptor antagonists target calcitonin gene-related peptide or its receptor to prevent migraine headaches or reduce their ... Cite journal requires ,journal= (help) Loder E, Renthal W (March 2019). "Calcitonin Gene-Related Peptide Monoclonal Antibody ... Medications in the anti-calcitonin gene-related peptide, including eptinezumab, erenumab, fremanezumab, and galcanezumab, ...
https://en.wikipedia.org/wiki/Migraine
Debbie Lucy HayDebbie Lucy Hay
"Regulation of signal transduction by calcitonin gene-related peptide receptors." Trends in Pharmacological Sciences 31, no. 10 ... "Pharmacological discrimination of calcitonin receptor: receptor activity-modifying protein complexes." Molecular Pharmacology ... Investigation of the calcitonin receptor-like receptor and receptor activity modifying proteins' at Imperial College London. ...
https://en.wikipedia.org/wiki/Debbie_Lucy_Hay
UbrogepantUbrogepant
It is the first drug in the class of oral calcitonin gene-related peptide receptor antagonists approved for the acute treatment ... It is a small-molecule calcitonin gene-related peptide receptor antagonist. The effectiveness of ubrogepant for the acute ...
https://en.wikipedia.org/wiki/Ubrogepant
AKTIPAKTIP
"A cDNA encoding the calcitonin gene-related peptide type 1 receptor". J Biol Chem. 271 (19): 11325-9. doi:10.1074/jbc.271.19. ... Lesche R, Peetz A, van der Hoeven F, Rüther U (1998). "Ft1, a novel gene related to ubiquitin-conjugating enzymes, is deleted ... AKT-interacting protein is a protein that in humans is encoded by the AKTIP gene. The mouse homolog of this gene produces fused ... This gene may play a role in apoptosis as these morphological abnormalities are caused by altered patterns of programmed cell ...
https://en.wikipedia.org/wiki/AKTIP
Neurogenic inflammationNeurogenic inflammation
The calcitonin gene-related peptide (CGRP) is a therapeutic target in migraine because of its hypothesized role in mediating ... In turn, histamine evokes the release of substance P and calcitonin gene-related peptide; thus, a bidirectional link between ... Durham PL, Vause CV (July 2010). "Calcitonin gene-related peptide (CGRP) receptor antagonists in the treatment of migraine". ... Calcitonin Gene-Related Peptide (CGRP), neurokinin A (NKA), and endothelin-3 (ET-3). In such neurons, release of these pro- ...
https://en.wikipedia.org/wiki/Neurogenic_inflammation
FremanezumabFremanezumab
It is in the calcitonin gene-related peptide antagonist class of medications. It was approved for medical use in the United ... Fremanezumab is a fully humanized monoclonal antibody directed against calcitonin gene-related peptides (CGRP) alpha and beta. ... Like other proteins, the substance is degraded by proteolysis to small peptides and amino acids, which are reused or excreted ...
https://en.wikipedia.org/wiki/Fremanezumab
RimegepantRimegepant
... is a small molecule calcitonin gene-related peptide (CGRP) receptor antagonist. Originally discovered at Bristol- ...
https://en.wikipedia.org/wiki/Rimegepant
Iain MacintyreIain Macintyre
Along with H. R. Morris he isolated and sequenced calcitonin gene-related peptide. Later research centred on the role played by ... His team also demonstrated calcitonin gene-related peptide, which they went on to sequence and then characterise. A major ... "The myotropic and plasma-calcium modulating effects of calcitonin gene-related peptide (CGRP)". Neuropeptides. 4 (5): 425-434. ... Macintyre's laboratory also purified and then sequenced both porcine calcitonin and human calcitonin. ...
https://en.wikipedia.org/wiki/Iain_Macintyre
Development of the endocrine systemDevelopment of the endocrine system
This stage is regulated by androgens, the genitofemoral nerve, and calcitonin gene-related peptide. During the second and third ... Studies of gene expression show that a specific complement of genes, such as follistatin and multiple cyclin kinase inhibitors ... Studies in mice have shown that interfering with the HOX15 gene can cause parathyroid gland aplasia, which suggests the gene ... Malformations in the GCM2 gene have resulted in hypoparathyroidism. Studies on SOX3 gene mutations have demonstrated that it ...
https://en.wikipedia.org/wiki/Development_of_the_endocrine_system
Parafollicular cellParafollicular cell
Kameda Y (October 1987). "Localization of immunoreactive calcitonin gene-related peptide in thyroid C cells from various ... Parafollicular cells secrete calcitonin, a hormone that participates in the regulation of calcium metabolism. Calcitonin lowers ... The primary function of these cells is to secrete calcitonin. They are located adjacent to the thyroid follicles and reside in ... Gkonos PJ, Tavianini MA, Liu CC, Roos BA (December 1989). "Thyrotropin-releasing hormone gene expression in normal thyroid ...
https://en.wikipedia.org/wiki/Parafollicular_cell
ErenumabErenumab
... , sold under the brand name Aimovig, is a medication which targets the calcitonin gene-related peptide receptor (CGRPR ... Erenumab is a fully human monoclonal antibody blocking the calcitonin gene-related peptide receptor (CGRPR). After subcutaneous ... Other anti-migraine antibodies blocking the calcitonin gene-related peptide (CGRP) pathway: Eptinezumab Fremanezumab ... Like other proteins, the substance is degraded by proteolysis to small peptides and amino acids. It has an elimination half- ...
https://en.wikipedia.org/wiki/Erenumab
RAMP3RAMP3
2004). "Intermedin is a calcitonin/calcitonin gene-related peptide family peptide acting through the calcitonin receptor-like ... CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin gene-related peptide (CGRP) receptor or ... 2008). "Identification of N-terminal receptor activity-modifying protein residues important for calcitonin gene-related peptide ... 2004). "Characterization of the human calcitonin gene-related peptide receptor subtypes associated with receptor activity- ...
https://en.wikipedia.org/wiki/RAMP3
RAMP2RAMP2
CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin gene-related peptide (CGRP) receptor or ... 2008). "Identification of N-terminal receptor activity-modifying protein residues important for calcitonin gene-related peptide ... 2004). "Characterization of the human calcitonin gene-related peptide receptor subtypes associated with receptor activity- ... of the cytoplasmic tails of the human receptor activity-modifying protein components of calcitonin gene-related peptide and ...
https://en.wikipedia.org/wiki/RAMP2
Circumventricular organsCircumventricular organs
... peptide histidine isoleucine, calcitonin gene-related peptide, substance P and somatostatin. Gross PM, Weindl A (1987). " ... Peptides. 31 (4): 757-76. doi:10.1016/j.peptides.2010.01.003. PMID 20093161. Morita S.; Miyata S. (2012). "Different vascular ... Other peptides aside from melatonin have been detected in the pineal. They are most likely associated with a type of ... Related to its secretory function, the SCO is partially composed of ependymal cells. These ependymocytes are characterized by ...
https://en.wikipedia.org/wiki/Circumventricular_organs
Pulp necrosisPulp necrosis
They can interact with neuropeptides (substance P) and calcitonin gene-related peptide (CGRP) during the inflammatory response ...
https://en.wikipedia.org/wiki/Pulp_necrosis
RAMP1RAMP1
"Functional calcitonin gene-related peptide receptors are formed by the asymmetric assembly of a calcitonin receptor-like ... CALCRL, a receptor with seven transmembrane domains, can function as either a calcitonin gene-related peptide (CGRP) receptor ... 2008). "Identification of N-terminal receptor activity-modifying protein residues important for calcitonin gene-related peptide ... 2004). "Characterization of the human calcitonin gene-related peptide receptor subtypes associated with receptor activity- ...
https://en.wikipedia.org/wiki/RAMP1
Parabrachial nucleiParabrachial nuclei
"Calcitonin gene-related peptide immunoreactivity in the visceral sensory cortex, thalamus, and related pathways in the rat". ... of neurons in the external lateral parabrachial subnucleus that contain the neurotransmitter calcitonin gene-related peptide ( ... The parabrachial nucleus relays satiety and pain-related signals to higher brain regions; when inhibited, this can produce " ... Peptides. 8 (2): 267-283. doi:10.1016/0196-9781(87)90102-1. ISSN 0196-9781. PMID 2884646. Kaur, Satvinder; Pedersen, Nigel P.; ...
https://en.wikipedia.org/wiki/Parabrachial_nuclei
Alternative splicingAlternative splicing
... calcitonin gene related peptide). Examples of alternative splicing in immunoglobin gene transcripts in mammals were also ... The gene encoding the thyroid hormone calcitonin was found to be alternatively spliced in mammalian cells. The primary ... Rosenfeld MG, Amara SG, Roos BA, Ong ES, Evans RM (March 1981). "Altered expression of the calcitonin gene associated with RNA ... Rosenfeld MG, Lin CR, Amara SG, Stolarsky L, Roos BA, Ong ES, Evans RM (March 1982). "Calcitonin mRNA polymorphism: peptide ...
https://en.wikipedia.org/wiki/Alternative_splicing
Hair cellHair cell
... terminal bouton is filled with vesicles containing acetylcholine and a neuropeptide called calcitonin gene-related peptide. The ... Not only do hair cells in a culture dish regenerate when the Rb1 gene is deleted, but mice bred to be missing the gene grow ... The Rb1 gene encodes the retinoblastoma protein, which is a tumor suppressor. Rb stops cells from dividing by encouraging their ... Henderson M (2005-01-15). "Gene that may no longer turn a deaf ear to old age". Times Online. Sage, Cyrille; Huang, Mingqian; ...
https://en.wikipedia.org/wiki/Hair_cell
Systematic evolution of ligands by exponential enrichmentSystematic evolution of ligands by exponential enrichment
"Short bioactive Spiegelmers to migraine-associated calcitonin gene-related peptide rapidly identified by a novel approach: ... Off-target binding to related molecules could have significant clinical effects. SELEX has been used to develop a number of ... Clinical uses of the technique are suggested by aptamers that bind tumor markers, GFP-related fluorophores, and a VEGF-binding ... Vavvas D, D'Amico DJ (September 2006). "Pegaptanib (Macugen): treating neovascular age-related macular degeneration and current ...
https://en.wikipedia.org/wiki/Systematic_evolution_of_ligands_by_exponential_enrichment
Jean-Pierre ChangeuxJean-Pierre Changeux
Fontaine B., Klarsfeld A., Hokfelt T., Changeux J.-P. (1986). Calcitonin gene-related peptide, a peptide present in spinal cord ... and a stimulation of gene transcription at the synapse by the calcitonin gene-related peptide (CGRP) activating PKA and the ... Laufer R., and Changeux J.-P. (1987). Calcitonin gene-related peptide elevates cyclic AMP levels in chick skeletal muscle : ... Fontaine B., Klarsfeld A., Changeux J.-P. (1987). Calcitonin-gene related peptide and muscle activity regulate acetylcholine ...
https://en.wikipedia.org/wiki/Jean-Pierre_Changeux
CapsinololCapsinolol
It is the first beta blocker with an associated calcitonin gene-related peptide releasing activity in the heart.[1] ... the first beta-adrenoceptor blocker with an associated calcitonin gene-related peptide releasing activity in the heart". Br J ... This drug article relating to the cardiovascular system is a stub. You can help Wikipedia by expanding it.. *v ...
https://en.wikipedia.org/wiki/Capsinolol
Glucagon receptorGlucagon receptor
"Receptor activity modifying protein-directed G protein signaling specificity for the calcitonin gene-related peptide family of ... "Tissue-specific and glucose-dependent expression of receptor genes for glucagon and glucagon-like peptide-1 (GLP-1)". Hormone ... Gene. 393 (1-2): 127-36. doi:10.1016/j.gene.2007.01.023. PMID 17374560. v t e. ... Shiota D, Kasamatsu T, Dib SA, Chacra AR, Moisés RS (May 2002). "Role of the Gly40Ser mutation in the glucagon receptor gene in ...
https://en.wikipedia.org/wiki/Glucagon_receptor
FZD5FZD5
This transmembrane receptor-related article is a stub. You can help Wikipedia by expanding it.. *v ... Gene ontology. Molecular function. • amyloid-beta binding. • signal transducer activity. • Wnt-protein binding. • protein ... Frizzled-5 is a protein that in humans is encoded by the FZD5 gene.[5][6][7] ... 2000). "LDL-receptor-related proteins in Wnt signal transduction". Nature. 407 (6803): 530-5. doi:10.1038/35035117. PMID ...
https://en.wikipedia.org/wiki/FZD5
Brain-derived neurotrophic factorBrain-derived neurotrophic factor
Genes on human chromosome 11. *Obsessive-compulsive disorder. *Neurotrophic factors. *Peptide hormones ... BDNF is a critical mediator of vulnerability to stress, memory of fear/trauma, and stress-related disorders such as post- ... Kaplan AS, Levitan RD, Yilmaz Z, Davis C, Tharmalingam S, Kennedy JL (January 2008). "A DRD4/BDNF gene-gene interaction ... Brain-derived neurotrophic factor (BDNF), or abrineurin,[5] is a protein[6] that, in humans, is encoded by the BDNF gene.[7][8] ...
https://en.wikipedia.org/wiki/BDNF
AKTIP - ويكيبيدياAKTIP - ويكيبيديا
"A cDNA encoding the calcitonin gene-related peptide type 1 receptor". J Biol Chem. 271 (19): 11325-9. doi:10.1074/jbc.271.19. ... Lesche R, Peetz A, van der Hoeven F, Rüther U (1998). "Ft1, a novel gene related to ubiquitin-conjugating enzymes, is deleted ... "Entrez Gene: AKTIP AKT interacting protein". مؤرشف من الأصل في 05 ديسمبر 2010.. الوسيط ,CitationClass=. تم تجاهله (مساعدة). ... Fluhmann B, Muff R, Hunziker W, Fischer JA, Born W (Feb 1995). "A human orphan calcitonin receptor-like structure". Biochem ...
https://ar.wikipedia.org/wiki/AKTIP
CD30CD30
"Entrez Gene: TNFRSF8 tumor necrosis factor receptor superfamily, member 8".. *^ Teng LH, Lu DH, Xu QZ, Fu YJ, Yang H, He ZL ( ... "Genes & Development. 11 (21): 2810-21. doi:10.1101/gad.11.21.2810. PMC 316646. PMID 9353251.. ... Gene ontology. Molecular function. • transmembrane signaling receptor activity. • tumor necrosis factor-activated receptor ... Fonatsch C, Latza U, Dürkop H, Rieder H, Stein H (Nov 1992). "Assignment of the human CD30 (Ki-1) gene to 1p36". Genomics. 14 ( ...
https://en.wikipedia.org/wiki/CD30
BradykininBradykinin
Calcitonin gene-related peptide. *Carnosine. *Cocaine- and amphetamine-regulated transcript. *Delta sleep-inducing peptide ... Bradykinin is a 9-amino acid peptide chain. The amino acid sequence of bradykinin is: Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg ( ... It is a peptide that causes blood vessels to dilate (enlarge), and therefore causes blood pressure to fall. A class of drugs ... The discovery was part of a continuing study on circulatory shock and proteolytic enzymes related to the toxicology of snake ...
https://en.wikipedia.org/wiki/Bradykinin
GPR120GPR120
Gene ontology. Molecular function. • peptide binding. • signal transducer activity. • taste receptor activity. • fatty acid ... This transmembrane receptor-related article is a stub. You can help Wikipedia by expanding it.. *v ... "Entrez Gene: GPR120 G protein-coupled receptor 120".. *^ Oh DY, Talukdar S, Bae EJ, Imamura T, Morinaga H, Fan W, Li P, Lu WJ, ... G-protein coupled receptor 120 is a protein that in humans is encoded by the GPR120 gene.[5][6] ...
https://en.wikipedia.org/wiki/GPR120
PuromycinPuromycin
Deletion of the gene encoding the multidrug efflux pump Pdr5 sensitizes cells to puromycin.[citation needed] ... The puromycin can then form a covalent link to the growing peptide chain allowing the mRNA to be physically linked to its ... Resistance to puromycin is conferred by the pac gene encoding a puromycin N-acetyl-transferase (PAC) that was found in a ... Puromycin resistance in yeast can also be conferred through expression of the puromycin N-acetyl-transferase (pac) gene.[8] ...
https://en.wikipedia.org/wiki/Puromycin
Insulin-like growth factor 2Insulin-like growth factor 2
Genes on human chromosome 11. *Peptide hormones. *Growth factors. *Hormones of the somatotropic axis ... As IGF2 promotes development of fetal pancreatic beta cells, it is believed to be related to some forms of diabetes mellitus. ... Gene structure[edit]. In humans, the IGF2 gene is located on chromosome 11p15.5, a region which contains numerous imprinted ... Gene ontology. Molecular function. • insulin receptor binding. • hormone activity. • GO:0001948 protein binding. • growth ...
https://en.wikipedia.org/wiki/Insulin-like_growth_factor_2
Brain-derived neurotrophic factorBrain-derived neurotrophic factor
Genes on human chromosome 11. *Obsessive-compulsive disorder. *Neurotrophic factors. *Peptide hormones ... In addition to mediating transient effects on NMDAR activation to promote memory-related molecular changes, BDNF should also ... Kaplan AS, Levitan RD, Yilmaz Z, Davis C, Tharmalingam S, Kennedy JL (January 2008). "A DRD4/BDNF gene-gene interaction ... Brain-derived neurotrophic factor, also known as BDNF, is a protein[5] that, in humans, is encoded by the BDNF gene.[6][7] BDNF ...
https://en.wikipedia.org/wiki/Brain_derived_neurotrophic_factor
GPR34GPR34
This transmembrane receptor-related article is a stub. You can help Wikipedia by expanding it.. *v ... Probable G-protein coupled receptor 34 is a protein that in humans is encoded by the GPR34 gene.[5][6][7] ... Gene ontology. Molecular function. • G-protein coupled purinergic nucleotide receptor activity. • G-protein coupled receptor ... "Physical mapping and exclusion of GPR34 as the causative gene for congenital stationary night blindness type 1". Human Genetics ...
https://en.wikipedia.org/wiki/GPR34
PeptidePeptide
Several terms related to peptides have no strict length definitions, and there is often overlap in their usage. ... gene-encoded antibacterial peptides from enterobacteria". Natural Product Reports. 24 (4): 708-34. doi:10.1039/b516237h. PMID ... Calcitonin peptidesEdit. *Calcitonin. *Amylin. *AGG01. Other peptidesEdit. *B-type Natriuretic Peptide (BNP) - produced in ... fungal peptides, invertebrate peptides, amphibian/skin peptides, venom peptides, cancer/anticancer peptides, vaccine peptides ...
https://en.m.wikipedia.org/wiki/Polypeptide
Adrenocorticotropic hormoneAdrenocorticotropic hormone
Calcitonin gene-related peptide. *Carnosine. *Cocaine- and amphetamine-regulated transcript. *Delta sleep-inducing peptide ... Glucocorticoids may also inhibit the rates of POMC gene transcription and peptide synthesis. The latter is an example of a slow ... A family of related receptors mediates the actions of these hormones, the MCR, or melanocortin receptor family. These are ... ACTH is also related to the circadian rhythm in many organisms.[2] ...
https://en.wikipedia.org/wiki/Adrenocorticotropic_hormone
HomeostasisHomeostasis
Gene regulation[edit]. Main article: Regulation of gene expression. At the cellular level, homeostasis is carried out by ... Other normal temperature variations include those related to the menstrual cycle.[15][16] The temperature regulator's set point ... This causes heart muscle cells to secrete the hormone atrial natriuretic peptide (ANP) into the blood. This acts on the kidneys ... The two homeostatic mechanisms working through PTH on the one hand, and calcitonin on the other can very rapidly correct any ...
https://en.wikipedia.org/wiki/Human_homeostasis
Adenosine receptorAdenosine receptor
"Entrez Gene: ADORA2A adenosine A2A receptor".. *^ a b Jacobson KA, Gao ZG (2006). "Adenosine receptors as therapeutic targets" ... age related changes as well as injury repair. ... Calcitonin. *CALCRL. *CD97. *Corticotropin-releasing hormone (1 ... rather than chondrocyte via the Runx2 gene expression.[24] Potential therapeutic application in aiding bone degenerative ... each is encoded by a different gene. ... Gene. Mechanism [15]. Effects. Agonists. Antagonists A1 ADORA1 ...
https://en.wikipedia.org/wiki/Adenosine_receptor
TelcagepantTelcagepant
... (INN) (code name MK-0974) is a calcitonin gene-related peptide receptor antagonist which was an investigational ... a new oral antagonist of calcitonin gene-related peptide receptor, compared with zolmitriptan for acute migraine: a randomised ...
https://en.wikipedia.org/wiki/Telcagepant
Galanin receptor 1Galanin receptor 1
This transmembrane receptor-related article is a stub. You can help Wikipedia by expanding it. *v ... "Alcoholism is associated with GALR3 but not two other galanin receptor genes". Genes, Brain, and Behavior. 6 (5): 473-81. PMID ... peptide hormone binding. • galanin receptor activity. • protein binding. Cellular component. • integral component of membrane. ... Gene ontology. Molecular function. • G-protein coupled receptor activity. • neuropeptide binding. • signal transducer activity ...
https://en.wikipedia.org/wiki/Galanin_receptor_1
FAKFAK
... family member HEF1 downstream of the G protein-coupled calcitonin receptor. Calcitonin induces the association of HEF1, ... "Focal adhesion kinase and paxillin bind to peptides mimicking beta integrin cytoplasmic domains". The Journal of Cell Biology ... "PTK2 - Focal adhesion kinase 1 - Gallus gallus (Chicken) - PTK2 gene & protein" (英語). www.uniprot.org. 2021年9月5日閲覧。. ... "Interaction of Hic-5, A senescence-related protein, with focal adhesion kinase". The Journal of Biological Chemistry 273 (41): ...
https://ja.wikipedia.org/wiki/FAK
کلسی‌تونین - ویکی‌پدیا، دانشنامهٔ آزادکلسی‌تونین - ویکی‌پدیا، دانشنامهٔ آزاد
Gene Ontology. Molecular function. • receptor binding. • hormone activity. • protein binding. • calcitonin receptor binding. • ... Calcitonin-related polypeptide alpha. NMR solution structure of salmon calcitonin in SDS micelles.[۱] ... "Structural determinants of salmon calcitonin bioactivity: the role of the Leu-based amphipathic alpha-helix". J. Biol. Chem. ... OMIM: 114130 MGI: 2151253 HomoloGene: 105263 ChEMBL: 5293 GeneCards: CALCA Gene. ...
https://fa.wikipedia.org/wiki/کلسی_تونین
TAS2R38TAS2R38
Taste receptor 2 member 38 is a protein that in humans is encoded by the TAS2R38 gene. TAS2R38 is a bitter taste receptor; ... was shown to be directly related to TAS2R38 genotype.[6][7][10][11][12] There are three common polymorphisms in the TAS2R38 ... Gene ontology. Molecular function. • G-protein coupled receptor activity. • signal transducer activity. • bitter taste receptor ... A gene altering the density of fungiform papillae may provide this second factor.[5] ...
https://en.wikipedia.org/wiki/TAS2R38
Neuromedin NNeuromedin N
Calcitonin gene-related peptide. *Carnosine. *Cocaine- and amphetamine-regulated transcript. *Delta sleep-inducing peptide ... Peptides. 27 (10): 2508-14. doi:10.1016/j.peptides.2006.03.038. PMID 16904237.. ... "Production of recombinant large proneurotensin/neuromedin N-derived peptides and characterization of their binding and ...
https://en.wikipedia.org/wiki/Neuromedin_N
Cysteinyl leukotriene receptor 2Cysteinyl leukotriene receptor 2
Gene ontology. Molecular function. • protein binding. • G-protein coupled peptide receptor activity. • signal transducer ... Perhaps related to this difference in CysLT sensitivities, cells co-expressing CysLTR2 and CysLTR1 may exhibit lower ... Gene[edit]. The human CysLTR2 gene maps to the long arm of chromosome 13 at position 13q14, a chromosomal region that has long ... The gene consists of four exons with all introns located in the genes' 5' UTR region and the entire coding region located in ...
https://en.wikipedia.org/wiki/Cysteinyl_leukotriene_receptor_2
Epidermal growth factorEpidermal growth factor
... and increases in the expression of certain genes including the gene for EGFR - that ultimately lead to DNA synthesis and cell ... Wikimedia Commons has media related to Epidermal growth factor, EGF.. *Shaanxi Zhongbang Pharma-Tech Co., Ltd.-Supply of ... EGF was originally described as a secreted peptide found in the submaxillary glands of mice and in human urine. EGF has since ... Gene ontology. Molecular function. • calcium ion binding. • transmembrane receptor protein tyrosine kinase activator activity. ...
https://en.wikipedia.org/wiki/Epidermal_growth_factor
Kalsitonin bahasa Indonesia, ensiklopedia bebasKalsitonin bahasa Indonesia, ensiklopedia bebas
... yang disebut calcitonin gene-related peptide (CGRP), jenis beta.[6] Berikut ini adalah urutan asam amino dari salmon dan ... "Calcitonin and calcitonin receptors". Regional Center for Hereditary Endocrine Tumors Department of Internal Medicine, ... "calcitonin domain annotation". SMART (a Simple Modular Architecture Research Tool). embl-heidelberg.de. Diakses tanggal 2009-02 ... Carney SL (1997). "Calcitonin and human renal calcium and electrolyte transport". Miner Electrolyte Metab. 23 (1): 43-7. PMID ...
https://id.wikipedia.org/wiki/Kalsitonin
OxytocinOxytocin
Calcitonin gene-related peptide. *Carnosine. *Cocaine- and amphetamine-regulated transcript. *Delta sleep-inducing peptide ... The two genes are believed to result from a gene duplication event; the ancestral gene is estimated to be about 500 million ... The oxytocin peptide is synthesized as an inactive precursor protein from the OXT gene.[18][19][20] This precursor protein also ... Sausville E, Carney D, Battey J (August 1985). "The human vasopressin gene is linked to the oxytocin gene and is selectively ...
https://en.wikipedia.org/wiki/Oxytocin
Erekcia (človek) - WikipédiaErekcia (človek) - Wikipédia
Vedľajšie: prostacyklín, VIP, CGRF (=Calcitonin Gene-Related Peptide), prostaglandíny - predovšetkým PGE1.. *Mediátory ...
https://sk.m.wikipedia.org/wiki/Erekcia_
GPR26GPR26
This transmembrane receptor-related article is a stub. You can help Wikipedia by expanding it.. *v ... Probable G-protein coupled receptor 26 is a protein that in humans is encoded by the GPR26 gene.[5] ... "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 ( ...
https://en.wikipedia.org/wiki/GPR26
GPERGPER
Choleris E (11 April 2013). Oxytocin, Vasopressin and Related Peptides in the Regulation of Behavior. Cambridge University ... cellular response to peptide hormone stimulus. • positive regulation of gene expression. • cellular response to ... "Entrez Gene: GPR30 G protein-coupled receptor 30".. *^ Hazell GG, Yao ST, Roper JA, Prossnitz ER, O'Carroll AM, Lolait SJ ( ... Gene ontology. Molecular function. • estrogen receptor activity. • steroid hormone binding. • chromatin binding. • protein ...
https://en.wikipedia.org/wiki/GPER
Tachykinin receptor 3Tachykinin receptor 3
See also: Receptor/signaling modulators • Signaling peptide/protein receptor modulators. This transmembrane receptor-related ... This gene belongs to a family of genes that function as receptors for tachykinins. Receptor affinities are specified by ... Tachykinin receptor 3, also known as TACR3, is a protein which in humans is encoded by the TACR3 gene.[5][6] ... "Entrez Gene: TACR3 tachykinin receptor 3".. *^ Quartara L, Altamura M (Aug 2006). "Tachykinin receptors antagonists: from ...
https://en.wikipedia.org/wiki/Tachykinin_receptor_3
calcitonin gene-related peptide | Modern medicinecalcitonin gene-related peptide | Modern medicine
calcitonin gene-related peptide. Migraine Pipeline and Impact Updates: What Health Execs Should Know. March 13, 2018By David ...
http://www.modernmedicine.com/tag/calcitonin-gene-related-peptide
Calcitonin gene-related peptide regulates muscle acetylcholine receptor synthesis. - PubMed - NCBICalcitonin gene-related peptide regulates muscle acetylcholine receptor synthesis. - PubMed - NCBI
A molecule immunologically related to calcitonin gene-related peptide (CGRP-I) has been found in motoneurones in a variety of ... Calcitonin gene-related peptide regulates muscle acetylcholine receptor synthesis.. New HV, Mudge AW. ...
https://www.ncbi.nlm.nih.gov/pubmed/3490625?dopt=Abstract
Calcitonin gene-related peptide - WikipediaCalcitonin gene-related peptide - Wikipedia
Calcitonin gene-related peptide (CGRP) is a member of the calcitonin family of peptides, which in humans exists in two forms: α ... Regulation of the calcitonin gene-related peptide (CGRP) gene is in part controlled by the expression of the mitogen-activated ... The mammalian calcitonin gene-related peptides, adrenomedullin, amylin, and calcitonin receptors". Pharmacological Reviews. 54 ... Prophylactic therapy with calcitonin gene‐related peptides (CGRPs) may have unknown fertility consequences for women of child ...
https://en.wikipedia.org/wiki/Calcitonin_gene-related_peptide
The CGRP Family: Calcitonin Gene-Related Peptide (CGRP), Amylin and AdThe CGRP Family: Calcitonin Gene-Related Peptide (CGRP), Amylin and Ad
... the Third International Meeting on CGRP and relate ... The CGRP Family: Calcitonin Gene-Related Peptide (CGRP), Amylin ... Calcitonin Gene-Related Peptide in Gastrointestinal Homeostasis 13. CGRP and Neurogenic Vasodilatation: Role of Nerve Growth ... This book is based on presentations given at CGRP 98, the Third International Meeting on CGRP and related peptides held in the ... Section 1: Pharmacology and Molecular Biology of CGRP Receptors 1. Multiple Receptors for CGRP and Related Peptides 2. CGRP ...
https://www.routledge.com/The-CGRP-Family-Calcitonin-Gene-Related-Peptide-CGRP-Amylin-and-Adrenomedullin/Poyner/p/book/9781587060045?utm_source=crcpress.com&utm_medium=referral
Calcitonin gene-related peptide receptor antagonist - WikipediaCalcitonin gene-related peptide receptor antagonist - Wikipedia
Calcitonin gene-related peptide (CGRP) receptor antagonists are a class of drug candidates that act as antagonists of the ... Mitsikostas, DD; Reuter, U (2017). "Calcitonin gene-related peptide monoclonal antibodies for migraine prevention: comparisons ... an Oral Calcitonin Gene Related Peptide Receptor Antagonist". British Journal of Clinical Pharmacology. 79 (5): 831-7. doi: ... calcitonin gene-related peptide receptor (CGRPR). CGRPR antagonists are under investigation as potential antimigraine agents ...
https://en.wikipedia.org/wiki/Calcitonin_gene-related_peptide_receptor_antagonist
What is the role of calcitonin gene-related peptide (CGRP) in the pathogenesis of anaphylaxis?What is the role of calcitonin gene-related peptide (CGRP) in the pathogenesis of anaphylaxis?
Calcitonin gene-related peptide (CGRP), a sensory neurotransmitter that is widely distributed in cardiovascular tissues, may ... What is the role of calcitonin gene-related peptide (CGRP) in the pathogenesis of anaphylaxis?. Updated: May 16, 2018 ... Calcitonin gene-related peptide (CGRP), a sensory neurotransmitter that is widely distributed in cardiovascular tissues, may ... encoded search term (What is the role of calcitonin gene-related peptide (CGRP) in the pathogenesis of anaphylaxis?) and What ...
https://www.medscape.com/answers/135065-52856/886641-overview
What is the role of calcitonin gene-related peptide (CGRP) in the pathogenesis of anaphylaxis?What is the role of calcitonin gene-related peptide (CGRP) in the pathogenesis of anaphylaxis?
Calcitonin gene-related peptide (CGRP), a sensory neurotransmitter that is widely distributed in cardiovascular tissues, may ... What is the role of calcitonin gene-related peptide (CGRP) in the pathogenesis of anaphylaxis?. Updated: May 16, 2018 ... Calcitonin gene-related peptide (CGRP), a sensory neurotransmitter that is widely distributed in cardiovascular tissues, may ... Anaphylaxis syndromes related to a new mammalian cross-reactive carbohydrate determinant. J Allergy Clin Immunol. 2009 Oct. 124 ...
https://www.medscape.com/answers/135065-52856/what-is-the-role-of-calcitonin-gene-related-peptide-cgrp-in-the-pathogenesis-of-anaphylaxis
Calcitonin Gene-related Peptide Levels in Chronic Migraine - Full Text View - ClinicalTrials.govCalcitonin Gene-related Peptide Levels in Chronic Migraine - Full Text View - ClinicalTrials.gov
Calcitonin. Salmon calcitonin. Calcitonin Gene-Related Peptide. Botulinum Toxins, Type A. abobotulinumtoxinA. Katacalcin. ... Calcitonin Gene-related Peptide Levels in Chronic Migraine. The safety and scientific validity of this study is the ... MedlinePlus related topics: Botox Genes and Gene Therapy Headache Migraine Drug Information available for: Calcitonin ... Elevated saliva calcitonin gene-related peptide levels during acute migraine predict therapeutic response to rizatriptan. ...
https://www.clinicaltrials.gov/ct2/show/NCT01071096
Amylin, calcitonin gene-related peptide, calcitonin, and adrenomedullin: a peptide superfamily. - PubMed - NCBIAmylin, calcitonin gene-related peptide, calcitonin, and adrenomedullin: a peptide superfamily. - PubMed - NCBI
The calcitonin gene peptide superfamily consists of calcitonin (CT), calcitonin gene-related peptide (CGRP), and amylin. CT and ... Amylin, calcitonin gene-related peptide, calcitonin, and adrenomedullin: a peptide superfamily.. Wimalawansa SJ1. ... Calcitonin Gene-Related Peptide/chemistry. *Calcitonin Gene-Related Peptide/genetics. *Calcitonin Gene-Related Peptide/ ... and amylin are related to the insulin gene superfamily of peptides, which may all have diverged from a common ancestral gene ...
https://www.ncbi.nlm.nih.gov/pubmed/9209829?dopt=Abstract
Calcb - Calcitonin gene-related peptide 2 - Mus musculus (Mouse) - Calcb gene & proteinCalcb - Calcitonin gene-related peptide 2 - Mus musculus (Mouse) - Calcb gene & protein
Calcitonin gene-related peptide 2. Calcitonin gene-related peptide 2 (Beta-type CGRP) (Calcitonin gene-related peptide II, CGRP ... IPR021117 Calcitonin-like. IPR021116 Calcitonin/adrenomedullin. IPR018360 Calcitonin_CS. IPR015476 Calcitonin_gene-rel_peptide ... IPR021117 Calcitonin-like. IPR021116 Calcitonin/adrenomedullin. IPR018360 Calcitonin_CS. IPR015476 Calcitonin_gene-rel_peptide ... Calcitonin gene-related peptide 2Imported. ,p>Information which has been imported from another database using automatic ...
https://www.uniprot.org/uniprot/Q3UW96
Distribution of substance P and the calcitonin gene-related peptide in the human tensor tympani muscle | SpringerLinkDistribution of substance P and the calcitonin gene-related peptide in the human tensor tympani muscle | SpringerLink
... and calcitonin gene-related peptide-immunoreactive nerve fiber (CGRP-IR NF) are important mediators of neurogenic inflammation ... Corcoran BM, Mayhew IG, Hahn CN, Prince DR (2000) Expression of vasoactive intestinal peptide, calcitonin gene-related peptide ... The distribution of nerve fibres immunoreactive for vasoactive intestinal peptide, calcitonin gene-related peptide, substance P ... The distribution of Calcitonin gene-related peptide-immunoreactive nerve fibers (CGRP-IR NFs) in the inner surface region of ...
https://link.springer.com/article/10.1007%2Fs00405-013-2469-1
Enhanced Vasodilator Responses to CGRP (Calcitonin Gene-Related Peptide) in Subcutaneous Arteries in Human HypertensionEnhanced Vasodilator Responses to CGRP (Calcitonin Gene-Related Peptide) in Subcutaneous Arteries in Human Hypertension
α-Calcitonin Gene Related Peptide, α-CGRP, ratα-Calcitonin Gene Related Peptide, α-CGRP, rat
Cardiovascular Related Peptides , α-Calcitonin Gene Related Peptide, α-CGRP, rat; α-CGRP is preferentially expressed in sensory ... Peptides , Cardiovascular Related Peptides ,, α-Calcitonin Gene Related Peptide, α-CGRP, rat. ... α - Calcitonin Gene Related Peptide, α - CGRP, rat. SCNTATCVTHRLAGLLSRSGGVVKDNFVPTNVGSEAF - NH2 (Disulfide bridge: 2 - 7). ...
https://anaspec.com/products/product.asp?id=58858
calcitonin gene related peptide Protocols and Video...'calcitonin gene related peptide' Protocols and Video...
... calcitonin gene related peptide include Primer-Free Aptamer Selection Using A Random DNA Library, Assessment of Vascular ... Calcitonin Gene-Related Peptide: Calcitonin gene-related peptide. A 37-amino acid peptide derived from the calcitonin gene. It ... The peptide produces multiple biological effects and has both circulatory and neurotransmitter modes of action. In particular, ... occurs as a result of alternative processing of mRNA from the calcitonin gene. The neuropeptide is widely distributed in neural ...
https://www.jove.com/keyword/calcitonin+gene+related+peptide
Frontiers | Protective Role of α-Calcitonin Gene-Related Peptide in Cardiovascular Diseases | PhysiologyFrontiers | Protective Role of α-Calcitonin Gene-Related Peptide in Cardiovascular Diseases | Physiology
"α-calcitonin gene related peptide (α-CGRP) is a regulatory neuropeptide of 37-amino acids. It is widely distributed in the ... "α-calcitonin gene related peptide (α-CGRP) is a regulatory neuropeptide of 37-amino acids. It is widely distributed in the ... α-Calcitonin gene-related peptide (α-CGRP) is a regulatory neuropeptide that belongs to the calcitonin/CGRP peptide family that ... 2000). Increased blood pressure in alpha-calcitonin gene-related peptide/calcitonin gene knockout mice. Hypertension 35, 470- ...
https://www.frontiersin.org/articles/10.3389/fphys.2019.00821/full
CALCB - Calcitonin gene-related peptide 2 precursor - Homo sapiens (Human) - CALCB gene & proteinCALCB - Calcitonin gene-related peptide 2 precursor - Homo sapiens (Human) - CALCB gene & protein
... help/peptide target=_top>More...,/a>,/p>PeptideiPRO_0000004087. 82 - 118. Calcitonin gene-related peptide 2Add BLAST. 37. ... IPR021117 Calcitonin-like. IPR021116 Calcitonin/adrenomedullin. IPR018360 Calcitonin_CS. IPR015476 Calcitonin_gene-rel_peptide ... IPR021117 Calcitonin-like. IPR021116 Calcitonin/adrenomedullin. IPR018360 Calcitonin_CS. IPR015476 Calcitonin_gene-rel_peptide ... sp,P10092,CALCB_HUMAN Calcitonin gene-related peptide 2 OS=Homo sapiens OX=9606 GN=CALCB PE=1 SV=1 ...
https://www.uniprot.org/uniprot/P10092
Dural Calcitonin Gene-Related Peptide Produces Female-Specific Responses in Rodent Migraine Models | Journal of NeuroscienceDural Calcitonin Gene-Related Peptide Produces Female-Specific Responses in Rodent Migraine Models | Journal of Neuroscience
Dural Calcitonin Gene-Related Peptide Produces Female-Specific Responses in Rodent Migraine Models. Amanda Avona, Carolina ... Calcitonin gene-related peptide (CGRP) has been implicated in the pathology of migraine for several decades. CGRP is elevated ... SIGNIFICANCE STATEMENT Calcitonin gene-related peptide (CGRP) has long been implicated in the pathophysiology of migraine, and ... 2017) The role of calcitonin gene-related peptide in peripheral and central pain mechanisms including migraine. Pain 158:543- ...
https://www.jneurosci.org/content/39/22/4323
Calcitonin Gene-Related Peptide (Cgrp), Adrenomedullin (Am), Amylin, And Calcitonin (Ct) Receptors And Overlapping Biological...Calcitonin Gene-Related Peptide (Cgrp), Adrenomedullin (Am), Amylin, And Calcitonin (Ct) Receptors And Overlapping Biological...
Calcitonin Gene-Related Peptide (Cgrp), Adrenomedullin (Am), Amylin, And Calcitonin (Ct) Receptors And Overlapping Biological ... J.A. Fischer, W. Born, and R. Muff, "Calcitonin Gene-Related Peptide (Cgrp), Adrenomedullin (Am), Amylin, And Calcitonin (Ct) ...
https://www.hindawi.com/journals/tswj/2001/646807/cta/
Induction of Insulin Resistance In Vivo by Amylin and Calcitonin Gene-Related Peptide | DiabetesInduction of Insulin Resistance In Vivo by Amylin and Calcitonin Gene-Related Peptide | Diabetes
During hyperinsulinemic glucose-clamp studies, intravenous infusion of calcitonin gene-related peptide (CGRP) in rats ... Induction of Insulin Resistance In Vivo by Amylin and Calcitonin Gene-Related Peptide. ... Induction of Insulin Resistance In Vivo by Amylin and Calcitonin Gene-Related Peptide ... Induction of Insulin Resistance In Vivo by Amylin and Calcitonin Gene-Related Peptide ...
http://diabetes.diabetesjournals.org/content/39/2/260
Calcitonin Gene-Related Peptide Summary Report | CureHunterCalcitonin Gene-Related Peptide Summary Report | CureHunter
Calcitonin gene-related peptide. A 37-amino acid peptide derived from the calcitonin gene. It occurs as a result of alternative ... The peptide produces multiple biological effects and has both circulatory and neurotransmitter modes of action. In particular, ... processing of mRNA from the calcitonin gene. The neuropeptide is widely distributed in neural tissue of the brain, gut, ... Calcitonin Gene Related Peptide; Calcitonin Gene Related Peptide I; Calcitonin Gene Related Peptide II; Gene-Related Peptide, ...
http://www.curehunter.com/public/keywordSummaryD015740-Calcitonin-Gene-Related-Peptide.do
Calcitonin gene-related peptide (CGRP) and cluster headacheCalcitonin gene-related peptide (CGRP) and cluster headache
... Belin, Andrea Carmine ; Ran, Caroline and Edvinsson, Lars LU (2020 ... Calcitonin gene-related peptide (CGRP) is a potent vasodilator, originating in trigeminal neurons and has a central role in CH ... Calcitonin gene-related peptide (CGRP) is a potent vasodilator, originating in trigeminal neurons and has a central role in CH ... Calcitonin gene-related peptide (CGRP) is a potent vasodilator, originating in trigeminal neurons and has a central role in CH ...
https://lup.lub.lu.se/search/publication/de44453f-818c-4e8d-b33b-fbdcb94ad5df
Calcitonin Gene Related Peptide - Pipeline Review, H2 2020Calcitonin Gene Related Peptide - Pipeline Review, H2 2020
H2 2020 Calcitonin Gene Related Peptide - Pipeline Review, H2 2020 Summary According to the recently published report ... Calcitonin Gene - Market research report and industry analysis - 13709614 ... Calcitonin Gene Related Peptide (CGRP) - Calcitonin gene related peptide (CGRP) is a member of the calcitonin family of ... Calcitonin Gene Related Peptide (CGRP) - Overview. Calcitonin Gene Related Peptide (CGRP) - Therapeutics Development. Products ...
https://www.marketresearch.com/Global-Markets-Direct-v3480/Calcitonin-Gene-Related-Peptide-Pipeline-13709614/
Calcitonin gene-related peptide does not excite or sensitize meningeal nociceptors: Implications for the pathophysiology of...Calcitonin gene-related peptide does not excite or sensitize meningeal nociceptors: Implications for the pathophysiology of...
Smriti Iyengar, Michael H. Ossipov, Kirk W. Johnson, The role of calcitonin gene-related peptide in peripheral and central pain ... Calcitonin gene-related peptide does not excite or sensitize meningeal nociceptors: Implications for the pathophysiology of ... A growing body of evidence points to a critical role of calcitonin gene-related peptide (CGRP) in the pathophysiology of ... Håkan Ashina, Lawrence Newman, Sait Ashina, Calcitonin gene-related peptide antagonism and cluster headache: an emerging new ...
http://onlinelibrary.wiley.com/doi/10.1002/ana.20619/full?globalMessage=0
Calcitonin Gene-Related Peptide (CGRP), a New Endocrine Factor Involved in the Complex Multi-hormonal Control of the Gill...Calcitonin Gene-Related Peptide (CGRP), a New Endocrine Factor Involved in the Complex Multi-hormonal Control of the Gill...
... calcitonin (CT) in the thyroid C cells and calcitonin gene-related peptide... ... alternative tissue-specific processing of initial mRNA from the calcitonin gene generates two distinct peptides: ... Calcitonin gene-related peptide in the regulation of cardiac function. Calcitonin gene-related peptide. The first decade of a ... Wimalawansa SJ (1997) Amylin, calcitonin gene-related peptide, calcitonin, and adrenomedullin: a peptide superfamily. Crit Rev ...
https://link.springer.com/chapter/10.1007/978-1-4020-9095-0_7
Pregnancy and Steroid Hormones Enhance the Systemic and Regional Hemodynamic Effects of Calcitonin Gene-Related Peptide in Rats1Pregnancy and Steroid Hormones Enhance the Systemic and Regional Hemodynamic Effects of Calcitonin Gene-Related Peptide in Rats1
Calcitonin gene-related peptide (CGRP) is a potent vasodilator neuropeptide known to be involved in the regulation of vascular ... Pregnancy and Steroid Hormones Enhance the Systemic and Regional Hemodynamic Effects of Calcitonin Gene-Related Peptide in Rats ... "Pregnancy and Steroid Hormones Enhance the Systemic and Regional Hemodynamic Effects of Calcitonin Gene-Related Peptide in Rats ... "Pregnancy and Steroid Hormones Enhance the Systemic and Regional Hemodynamic Effects of Calcitonin Gene-Related Peptide in Rats ...
https://bioone.org/journals/Biology-of-Reproduction/volume-64/issue-6/biolreprod64.6.1776/Pregnancy-and-Steroid-Hormones-Enhance-the-Systemic-and-Regional-Hemodynamic/10.1095/biolreprod64.6.1776.short
Role of calcitonin gene-related peptide and brain natriuretic peptide | JRLCRRole of calcitonin gene-related peptide and brain natriuretic peptide | JRLCR
Using calcitonin gene-related peptide (CGRP) and brain natriuretic peptide (BNP) as examples, this review addresses the ... For either peptide, the key target appears to be the ATP-gated P2X3 receptor that, widely expressed by trigeminal sensory ... The fine balance between the activities of these peptides is suggested to ultimately determine whether nociception is perceived ... to sequester this peptide or to directly inhibit its receptor) is currently considered a novel approach for migraine ...
https://www.dovepress.com/role-of-calcitonin-gene-related-peptide-and-brain-natriuretic-peptide--peer-reviewed-article-JRLCR
Frontiers | New Trends in Migraine Pharmacology: Targeting Calcitonin Gene-Related Peptide (CGRP) With Monoclonal Antibodies |...Frontiers | New Trends in Migraine Pharmacology: Targeting Calcitonin Gene-Related Peptide (CGRP) With Monoclonal Antibodies |...
The demonstrated pivotal role of calcitonin gene-related peptide (CGRP) has fostered the development of CGRP antagonists, ... The demonstrated pivotal role of calcitonin gene-related peptide (CGRP) has fostered the development of CGRP antagonists, ... Pathophysiology of Migraine and Calcitonin Gene-Related Peptide (CGRP). The exact cause of migraine attacks is not well known ... Russell, F. A., King, R., Smillie, S. J., Kodji, X., and Brain, S. D. (2014). Calcitonin gene-related peptide: physiology and ...
https://www.frontiersin.org/articles/10.3389/fphar.2019.00363/full
Abstract 605: Calcitonin Gene Related Peptide (cgrp) And Its Role In Cardiovascular And Autonomic Regulation | HypertensionAbstract 605: Calcitonin Gene Related Peptide (cgrp) And Its Role In Cardiovascular And Autonomic Regulation | Hypertension
Abstract 605: Calcitonin Gene Related Peptide (cgrp) And Its Role In Cardiovascular And Autonomic Regulation. Tu Mai, Andre M ... Calcitonin gene related peptide (CGRP) is the most potent microvascular vasodilator known. It exerts effects centrally as well ... Abstract 605: Calcitonin Gene Related Peptide (cgrp) And Its Role In Cardiovascular And Autonomic Regulation ... Abstract 605: Calcitonin Gene Related Peptide (cgrp) And Its Role In Cardiovascular And Autonomic Regulation ...
http://hyper.ahajournals.org/content/60/Suppl_1/A605
Calcitonin gene-related peptide - Biology-Online Dictionary | Biology-Online DictionaryCalcitonin gene-related peptide - Biology-Online Dictionary | Biology-Online Dictionary
Calcitonin gene-related peptide (Science: protein) a second product transcribed from the calcitonin gene. Calcitonin gene ... Retrieved from "https://www.biology-online.org/dictionary/index.php?title=Calcitonin_gene-related_peptide&oldid=64605" ... It occurs as a result of alternative processing of mrna from the calcitonin gene. ... related peptide is found in a number of tissues including nervous Tissue. It is a vasodilator that may participate in the ...
https://www.biology-online.org/dictionary/Calcitonin_gene-related_peptide
Calcitonin Gene-Related Peptide in the Bed Nucleus of the Stria Terminalis Produces an Anxiety-Like Pattern of Behavior and...Calcitonin Gene-Related Peptide in the Bed Nucleus of the Stria Terminalis Produces an Anxiety-Like Pattern of Behavior and...
Calcitonin gene-related peptide (CGRP) is one such peptide. CGRP innervation of the BNST arises primarily from parabrachial ... 1996) The effects of central injections of calcitonin gene-related peptide on fear-related behavior. Neurobiol Learn Mem 66:241 ... 2005) Calcitonin gene-related peptide-containing pathways in the rat forebrain. J Comp Neurol 489:92-119. ... Calcitonin Gene-Related Peptide in the Bed Nucleus of the Stria Terminalis Produces an Anxiety-Like Pattern of Behavior and ...
https://www.jneurosci.org/content/31/5/1802?ijkey=9000db241caf815f67fcd61dc5d6a18939e569a9&keytype2=tf_ipsecsha
CGRPAdrenomedullinReceptorsNeuropeptideAlpha-Calcitonin gene-reVasodilatorNeuronsImmunoreactivityHUMAN CalcitoninPolypeptideSensoryMonoclonalEndogenousAmino acidsPharmacologyAntagonistMRNASubstanceAntibodiesSynthesisPathwaysAntagonismGastricSubarachnoid hemorrhageCGRPsIschemiaCluster headacheResponsesReceptor calledThyroidAffinityExpressionNeurotransmitterHypertensionHomologousAntibody1991Protein-coupled receptorCoronary arteryInhibits
CGRP133
  • Calcitonin gene-related peptide (CGRP) is a member of the calcitonin family of peptides, which in humans exists in two forms: α-CGRP and β-CGRP, also known as CGRP I and CGRP II. (wikipedia.org)
  • CGRP I or α-CGRP is a 37-amino acid neuropeptide and is formed from the alternative splicing of the calcitonin/CGRP gene located on chromosome 11. (wikipedia.org)
  • In humans, β-CGRP differs from the α-CGRP by three amino acids and is encoded in a separate gene within the same vicinity. (wikipedia.org)
  • The CGRP family includes calcitonin (CT), adrenomedullin (AM), and amylin (AMY). (wikipedia.org)
  • CGRP mediates its effects through a heteromeric receptor composed of a G protein-coupled receptor called calcitonin receptor-like receptor (CALCRL) and a receptor activity-modifying protein (RAMP1). (wikipedia.org)
  • Regulation of the calcitonin gene-related peptide (CGRP) gene is in part controlled by the expression of the mitogen-activated protein kinases (MAPK) signaling pathway, cytokines such as TNFα and iNOS. (wikipedia.org)
  • The CGRP receptor has three subunits: receptor activity-modifying protein 1 (RAMP1), calcitonin-like receptor (CLR) and receptor component protein (RCP). (wikipedia.org)
  • The complex central receptor is the G protein-coupled receptor calcitonin receptor-like receptor (CALCRL) which is necessary for CGRP and adrenomedullin (AM receptors). (wikipedia.org)
  • A molecule immunologically related to calcitonin gene-related peptide (CGRP-I) has been found in motoneurones in a variety of mammals including man. (nih.gov)
  • Calcitonin gene-related peptide (CGRP) receptor antagonists are a class of drug candidates that act as antagonists of the calcitonin gene-related peptide receptor (CGRPR). (wikipedia.org)
  • This book is based on presentations given at CGRP '98, the Third International Meeting on CGRP and related peptides held in the UK in May 1998. (routledge.com)
  • An exciting story is emerging of how a single molecule, calcitonin receptor-like receptor (CRLR), can mediate the response to both CGRP and adrenomedullin depending on the presence of different members of a family of accessory proteins, the Receptor Activity Modifying Proteins (RAMPs). (routledge.com)
  • Multiple Receptors for CGRP and Related Peptides 2. (routledge.com)
  • What is the role of calcitonin gene-related peptide (CGRP) in the pathogenesis of anaphylaxis? (medscape.com)
  • Calcitonin gene-related peptide (CGRP), a sensory neurotransmitter that is widely distributed in cardiovascular tissues, may help to counteract coronary artery vasoconstriction during anaphylaxis. (medscape.com)
  • Twenty patients will be enrolled in a 2-site, 7-month, double-blind study conducted to evaluate a reduction in headache days and attacks and calcitonin gene-related peptide (CGRP) levels in saliva following treatment with OnabotulinumtoxinA versus saline. (clinicaltrials.gov)
  • The calcitonin gene peptide superfamily consists of calcitonin (CT), calcitonin gene-related peptide (CGRP), and amylin. (nih.gov)
  • CT and CGRP derive from the CT/CGRP gene, which is encoded on chromosome 11. (nih.gov)
  • Alternative splicing of the primary RNA transcript leads to the translation of CGRP and CT peptides in a tissue-specific manner. (nih.gov)
  • CGRP (a 37-amino-acid neuropeptide) and its receptors are widely distributed in the body, and it is the most potent endogenous vasodilatory peptide discovered so far. (nih.gov)
  • Amylin (a 37-amino-acid peptide) is generated from a gene located on chromosome 12 (thought to be an evolutionary duplication of chromosome 11) and shares 46% amino acid sequence homology with CGRP and 20% with human CT. (nih.gov)
  • Adrenomedullin, a recently discovered 52-amino-acid vasoactive peptide from adrenal tissue, shares 24% homology with CGRP and is also a member of this superfamily of peptides. (nih.gov)
  • Not only does adrenomedullin (13-52) show 24% amino acid homology with CGRP, it also has a biological activity profile similar to that of CGRP.CGRP, CT, and amylin are related to the insulin gene superfamily of peptides, which may all have diverged from a common ancestral gene during evolution. (nih.gov)
  • When the crystallographic- and nuclear magnetic resonance-based molecular modeling of the three-dimensional structure of CGRP, CT, amylin, and adrenomedullin peptides and their receptors is available, it will lead to a greater understanding of the involvement of this family of peptides in pathophysiology. (nih.gov)
  • I propose that CT, CGRP, adrenomedullin, and amylin belong to a family of G-protein-coupled receptors (an "insulin superfamily" of peptides) and therefore share some of the characteristics of insulin, such as growth factor-like effects, and possible interaction at insulin receptor sites as an antagonist. (nih.gov)
  • Substance P-immunoreactive nerve fiber (SP-IR NF) and calcitonin gene-related peptide-immunoreactive nerve fiber (CGRP-IR NF) are important mediators of neurogenic inflammation and blood supply. (springer.com)
  • α-Calcitonin gene-related peptide (α-CGRP) is a regulatory neuropeptide of 37 amino acids. (frontiersin.org)
  • In thyroid C cells, the CALC-I gene product containing exon 4 forms calcitonin, whereas the CALC-I gene product containing exons 5 and 6 forms α-CGRP in sensory neurons ( Figure 1 ). (frontiersin.org)
  • Peptide α-CGRP is a single polypeptide of 37 amino acids containing a disulfide bridge between positions 2 and 7 and a phenylalanine amide residue at the C-terminal. (frontiersin.org)
  • Schematic diagram showing the synthesis of calcitonin and α-CGRP from a common gene CALC-I. Calcitonin gene CALC-I undergoes alternative splicing and forms protein calcitonin in thyroid C cells, and α-CGRP in the sensory neurons. (frontiersin.org)
  • Using preclinical behavioral models of migraine, we show that application of calcitonin gene-related peptide (CGRP) to the rat dura mater produces cutaneous periorbital hypersensitivity. (jneurosci.org)
  • SIGNIFICANCE STATEMENT Calcitonin gene-related peptide (CGRP) has long been implicated in the pathophysiology of migraine, and CGRP-based therapeutics are efficacious for the treatment of migraine in humans. (jneurosci.org)
  • Muscle inflammation and hyperalgesia induced by adjuvant injection into skeletal muscle are associated with an increase in calcitonin gene-related peptide (CGRP) labeling in skeletal muscle and dorsal root ganglia (DRG). (cdc.gov)
  • Amylin is a peptide isolated from amyloid deposits in pancreatic islets of type II (non-insulin-dependent) diabetic subjects, is present in normal β-cells, and bears a striking homology to CGRP. (diabetesjournals.org)
  • Calcitonin gene-related peptide (CGRP) is a potent vasodilator, originating in trigeminal neurons and has a central role in CH pathophysiology. (lu.se)
  • Calcitonin Gene Related Peptide (CGRP) pipeline Target constitutes close to 12 molecules. (marketresearch.com)
  • Calcitonin Gene Related Peptide (CGRP) - Calcitonin gene related peptide (CGRP) is a member of the calcitonin family of peptides. (marketresearch.com)
  • It also reviews key players involved in Calcitonin Gene Related Peptide (CGRP) targeted therapeutics development with respective active and dormant or discontinued projects. (marketresearch.com)
  • A growing body of evidence points to a critical role of calcitonin gene-related peptide (CGRP) in the pathophysiology of migraine headache. (wiley.com)
  • A current hypothesis suggests that peripheral CGRP and its related meningeal vasodilatation results in activation and sensitization, leading to the generation of migraine headache. (wiley.com)
  • In mammals, alternative tissue-specific processing of initial mRNA from the calcitonin gene generates two distinct peptides: calcitonin (CT) in the thyroid C cells and calcitonin gene-related peptide (CGRP) in the peripheral and central nerves (Copp et al. (springer.com)
  • Arlot-Bonnemains Y, Fouchereau-Peron M, Julienne A, Milhaud G, Moukhtar MS (1991) Binding sites of calcitonin gene related peptide (CGRP) to trout tissues. (springer.com)
  • Brain SD (2004) Calcitonin gene-related peptide (CGRP) antagonists: blockers of neuronal transmission in migraine. (springer.com)
  • Calcitonin gene-related peptide (CGRP) is a potent vasodilator neuropeptide known to be involved in the regulation of vascular resistance. (bioone.org)
  • Using calcitonin gene-related peptide (CGRP) and brain natriuretic peptide (BNP) as examples, this review addresses the mechanisms through which neuropeptides might modulate nociceptor activity. (dovepress.com)
  • One attractive notion is that pain signaling by trigeminal sensory neurons is potently regulated by the ambient levels of these peptides: CGRP is thought to facilitate neuronal firing responsible for trigeminal sensitization necessary to trigger headache, whereas BNP is proposed to act as a negative regulator of trigeminal neuron activity. (dovepress.com)
  • Hence, the clinical goal of CGRP antagonism using either pharmacological receptor blockers or monoclonal antibodies (to sequester this peptide or to directly inhibit its receptor) is currently considered a novel approach for migraine prophylaxis and to treat acute headache attacks. (dovepress.com)
  • The demonstrated pivotal role of calcitonin gene-related peptide (CGRP) has fostered the development of CGRP antagonists, unfortunately endowed with liver toxicity, and monoclonal antibodies (mAbs) toward circulating CGRP released during migraine attack or targeting its receptor. (frontiersin.org)
  • Calcitonin gene related peptide (CGRP) is the most potent microvascular vasodilator known. (ahajournals.org)
  • Calcitonin gene-related peptide (CGRP) evokes anxiety-like responses when infused into the lateral ventricle of rats. (jneurosci.org)
  • Calcitonin gene-related peptide (CGRP) is one such peptide. (jneurosci.org)
  • The aim of the present study is to explore functional consequences of migraine gene mutations on their responses to Calcitonin Gene Related Peptide (CGRP)infusion. (clinicaltrials.gov)
  • Calcitonin Gene Related Peptide (CGRP) induces migraine attacks indistinguishable from spontaneous attacks in approximately 50% of migraine sufferers. (clinicaltrials.gov)
  • Calcitonin gene-related peptide (CGRP) is a pivotal messenger in the inflammatory process in migraine. (mdpi.com)
  • The objective of this study was to investigate the effects of foods and a dietary supplement on two migraine-related mechanisms in vitro: CGRP secretion from neuroendocrine CA77 cells, and calcium uptake by differentiated PC12 cells. (mdpi.com)
  • To explore the role of anandamide (AEA) transporter in regulating calcitonin gene-related peptide (CGRP) production and blood pressure. (unboundmedicine.com)
  • The neuropeptide calcitonin gene-related peptide (CGRP) expressed by one-third of rat dorsal root ganglion (DRG) neurons mediates pain sensation and vasodilation. (nih.gov)
  • These drugs are the first to test monoclonal antibodies for migraine prevention and both target the protein calcitonin gene-related peptide (CGRP). (thedailyheadache.com)
  • OBJECTIVE: The goal of this work was to investigate the efficacy of a calcitonin gene-related peptide (CGRP) slow-release tablet (CGRP tablet) for the prevention of cerebral vasospasm after subarachnoid hemorrhage (SAH). (biomedsearch.com)
  • Substance P (SP), calcitonin gene-related peptide (CGRP), and isolectin B4 (IB4) are widely used as markers for peripheral neurons with unmyelinated fibers, whereas neurofilament 200 (NF200), and Peripherin are used as markers for neurons with myelinated fibers, and with unmyelinated or small-caliber fibers, respectively. (unboundmedicine.com)
  • One of these mediators, calcitonin gene-related peptide (CGRP), is a neuropeptide released from nerve endings in the skin. (jimmunol.org)
  • CGRP binds to its receptors composed of receptor activity-modifying protein 1 and calcitonin receptor-like receptor to modulate immune cell function. (jimmunol.org)
  • As one of those molecules, calcitonin gene-related peptide (CGRP) and its immunoregulatory functions have been studied. (jimmunol.org)
  • CGRP binds to its specific receptor composed of receptor activity-modifying protein 1 (RAMP1) and calcitonin receptor-like receptor (CLR) ( 3 ). (jimmunol.org)
  • Effects of long-term treatment with angiotensin converting enzyme (ACE) inhibitor on decreased function of calcitonin gene-related peptide (CGRP)-containing vasodilator nerves (CGRP nerves) in mesenteric resistance artery were investigated in spontaneously hypertensive rats (SHR). (nii.ac.jp)
  • 120 pmol kg-1 of CGRP was given to all the animals, the conscious animals receiving the peptide in one infusion lasting 4 min. (lu.se)
  • The patterns shows a resemblance to that obtained in other species, but there are some marked differences, The tissues most susceptible to the peptide are those easily exposed to noxious stimuli and containing CGRP in the sensory nerve endings, observations in agreement with the proposed role for the peptide in neurogenic defence mechanisms. (lu.se)
  • Purpose of review Monoclonal antibodies (mAbs) targeting the calcitonin-gene-related peptide (CGRP) pathway have been developed for episodic and chronic migraine prevention, either through binding the CGRP ligand (eptinezumab, fremanezumab, galcanezumab) or the CGRP receptor (erenumab). (eur.nl)
  • Calcitonin gene-related peptide (CGRP), a potent vasodilatory and cardiotonic peptide, has a potential role for CGRP in diverse physiologic and pathophysiologic situations such as congestive heart failure, diabetes, migraine, and neurogenic inflammation. (aspetjournals.org)
  • Although a peptide CGRP receptor antagonist, CGRP 8-37, is available, its utility presents significant limitations for these indications. (aspetjournals.org)
  • Calcitonin gene-related peptide (CGRP) is a polypeptide produced by alternative processing of calcitonin gene transcripts and is endowed with important systemic physiological effects. (eurekaselect.com)
  • Among other neuropeptides, sensory neurons contain calcitonin gene-related peptide (CGRP) and release CGRP in response to noxious stimulation. (ovid.com)
  • Calcitonin gene-related peptide (CGRP) and substance P (SP) which is potent vasodilator neuropeptides play a counter-regulatory role in several models of experimental hypertension. (academicjournals.org)
  • Langendorff-perfused mouse hearts (n = 328) were used to compare coronary flow rates among wild type (WT), a-CGRP gene knockout (KO) and NK1-KO mice under various pressure loading conditions (20, 30, 40 and 50 mmHg). (academicjournals.org)
  • Deletion of a-CGRP gene resulted in a significant reduction in coronary flow rate for both genders at all pressures. (academicjournals.org)
  • This effect seems to be gender related with less coronary flow noted in female WT and a-CGRP-KO mice, but not in NK1-KO mice. (academicjournals.org)
  • In order to notably improve bone quality in RA patients for successful TJA surgery, we are investigating the role of calcitonin gene-related peptide (CGRP), a neuropeptide of the Calcitonin family. (egms.de)
  • The involvement of calcitonin gene-related peptide (CGRP) in migraine pathophysiological mechanisms is shown by the facts that CGRP can induce migraine and that two CGRP antagonists, olcegepant and telcagepant, are effective in the treatment of migraine attacks. (nih.gov)
  • Calcitonin gene-related peptide (CGRP) probably has a role in migraine pathophysiology, and antagonism of its receptors might provide treatment without the vasoconstrictor effects of triptans. (prohealth.com)
  • Calcitonin gene-related peptide (CGRP) has recently been demonstrated in sensory neurons of the eye. (arvojournals.org)
  • One of the potential pathways for prophylaxis involves Calcitonin Gene-Related Peptide (CGRP) modulation. (cpnp.org)
  • We previously reported that endogenous prostaglandin I 2 , generated by a mild irritant, sensitised calcitonin gene related peptide (CGRP) containing sensory nerves and facilitated the release of CGRP and gastric mucosal protection against ethanol. (bmj.com)
  • In cultured chicken myotubes, calcitonin gene-related peptide (CGRP), a peptide present in spinal cord motoneurons, increased by 1.5-fold the number of surface acetylcholine receptors (AChRs) and by threefold AChR alpha-subunit mRNA level without affecting the level of muscular alpha-actin mRNA. (rupress.org)
  • These data suggest that distinct second messengers are involved in the regulation of AChR biosynthesis by CGRP and muscle activity and that these two pathways may contribute to the development of different patterns of AChR gene expression in junctional and extrajunctional areas of the muscle fiber. (rupress.org)
  • Calcitonin gene-related peptide (CGRP) is known to be closely involved in the cascade of events that lead to a migraine attack. (headacheaustralia.org.au)
  • These same brain structures cause peptides including CGRP, to be released. (headacheaustralia.org.au)
  • Using an immunocytochemical technique, we have studied the distribution of fibers and cell bodies containing somatostatin-28 (1-12) [SOM-28 (1-12)], calcitonin gene-related peptide (CGRP), and substance P (SP) in the brainstem of Saimiri sciureus . (springer.com)
  • Calcitonin gene-related peptide (CGRP) receptors were solubilized from rat cerebellum membranes in an active, stable, and guanine nucleotide-sensitive form by using digitonin. (aspetjournals.org)
  • Global Markets Direct's, 'Calcitonin Gene Related Peptide (CGRP)- Pipeline Review, H2 2019', provides in depth analysis on Calcitonin Gene Related Peptide (CGRP) targeted pipeline therapeutics. (globalmarketsdirect.com)
  • Additionally, the report provides an overview of key players involved in Calcitonin Gene Related Peptide (CGRP) targeted therapeutics development and features dormant and discontinued projects. (globalmarketsdirect.com)
  • The report analyses the pipeline products from therapy areas Central Nervous System and Immunology under development targeting Calcitonin Gene Related Peptide (CGRP). (globalmarketsdirect.com)
  • In such epithelia, LCs are in direct contact with peripheral neurons secreting calcitonin gene-related peptide (CGRP). (inserm.fr)
  • Calcitonin gene-related peptide (CGRP) is a neuropeptide that has a variety of physiological functions. (arvojournals.org)
  • Following Sep-pak extraction, calcitonin gene-related peptide immunoreactivity (CGRP-LI) was determined by radioimmunoassay in sample aliquots. (eurekamag.com)
  • Several immu-no-his-to-chem-i-cal stud-ies con-duct-ed in the -acute -phase fol-low-ing SAH -have dem-on-strat-ed a -marked deple-tion of cer-tain pep-tides -like Substance P (SP), Calcitonin Gene Related Peptide (CGRP) -from the adven-ti-tia of per-i-vas-cu-lar -nerves. (minervamedica.it)
  • To assess joint nociceptor activation indirectly, we used a novel in vitro knee joint preparation and determined the release of calcitonin gene-related peptide (CGRP) and prostaglandin E2 (PGE2) in osteoarthritic mice. (jrheum.org)
  • The neuropeptide calcitonin gene-related peptide (CGRP) is concentrated in fine sensory nerve endings innervating all tissues, including bone. (galileo-training.com)
  • To investigate the role of CGRP in bone in vivo, mice were engineered to express CGRP in osteoblasts by placing the human CGRP gene under the control of the rat osteocalcin promoter (Ost-CGRP tg+ mice). (galileo-training.com)
  • It could be terminated by adding calcitonin-gene related peptide (CGRP), most likely because CGRP causes ET-1/ETAR dissociation. (eur.nl)
  • Calcitonin gene-related peptide (CGRP) is an endogenous neuropeptide that exhibits anti-inflammatory, anti-resorptive, anxiogenic, neuroprotective, and pro-angiogenic activities. (lktlabs.com)
  • The neuropeptide calcitonin gene-related peptide (CGRP) prevents inflammatory liver injury in mice. (lktlabs.com)
  • The effects of long-term administration of paclitaxel on the function of sensory neurons grown in culture, using the release of the neuropeptide calcitonin gene-related peptide (CGRP) as an endpoint of sensory neuronal function, were examined. (iupui.edu)
  • The aim of this study was to investigate whether expression of γ-aminobutyric acid (GABA) and the neuropeptides substance P (SP) and calcitonin gene-related peptide (CGRP) in the primary sensory neurons of cervical dorsal root ganglia (DRG) are involved in electroacupuncture (EA)-induced analgesia in a rat model of incisional neck pain. (bmj.com)
  • Conclusions EA at LI18/LI4-PC6 increases PT in rats with incisional neck pain, which is likely related to downregulation of pronociceptive mediators SP/CGRP and upregulation of the inhibitory transmitter GABA in the primary sensory neurons of cervical DRGs. (bmj.com)
  • Peptide-Human Calcitonin Gene Related Peptide (CGRP) Control/blocking peptide #1-Alpha Diagnostic International Inc. (4adi.com)
  • The co-expression of ASIC3 with calcitonin gene-related peptide (CGRP) or parvalbumin (PV) was examined in the trigeminal ganglion (TG) by a double immunofluorescence method. (semanticscholar.org)
  • MBS029789 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Calcitonin Gene Related Peptide (CGRP) ELISA Kit target analytes in biological samples. (mybiosource.com)
  • NCBI/Uniprot data below describe general gene information for CGRP . (mybiosource.com)
  • Calcitonin gene-related peptide (CGRP) has been reported to play an important role in the proliferation of various types of epithelial and endothelial cells. (biomedcentral.com)
  • Calcitonin gene-related peptide (CGRP) is a target for cardiovascular gene therapy. (elsevier.com)
  • To determine the feasibility of adenoviral-mediated CGRP gene transfer into ex vivo-expanded MSCs, rat MSCs were isolated, ex vivo expanded, and transduced with adenoviruses. (elsevier.com)
  • Adprepro-CGRP and AdntlacZ, adenoviral vectors containing prepro-CGRP or nuclear-targeted β-galactosidase reporter gene ntlacZ under the control of Rous sarcoma virus promoter, were used. (elsevier.com)
  • These findings suggest that replication-deficient recombinant adenovirus can be used to gene engineer ex vivo-expanded MSCs and that high-level secretion of biologically active CGRP can be achieved, underscoring the clinical potential of using this novel adult stem cell-based cell and gene therapy strategy for the treatment of cardiovascular diseases. (elsevier.com)
  • We investigated the protein and mRNA expression of calcitonin gene-related peptide (CGRP) in endothelial cells of the rat thoracic aorta and femoral artery. (um.es)
  • In the present study, we explored the mechanisms of possible involvement and regulation of substance P (SP) and calcitonin gene-related peptide (CGRP) in the pathological and inflammatory processes of arthritis in DDH. (biomedcentral.com)
  • Radiographs depicting moderate developmental dysplasia of the hip (DDH) (A) and severe DDH (B) . mRNA expression of substance P (SP) (C) and calcitonin gene-related peptide (CGRP) (D) in synovial tissues obtained from patients in the study groups: moderate DDH ( n = 10), severe DDH ( n = 11) and control ( n = 8). (biomedcentral.com)
  • Calcitonin gene-related peptide (CGRP), a neuropeptide, is a naturally occurring vasodilator with no constrictive effects. (elsevier.com)
  • Protons can release in a Ca(2+)-dependent manner, calcitonin gene-related peptide (CGRP)-like immunoreactivity from peripheral endings of capsaicin-sensitive afferents. (mysciencework.com)
  • Transient hyperthermic shifts in body temperature have been linked to the endogenous hormone calcitonin gene-related peptide (CGRP), which can increase sympathetic activation and metabolic heat production. (biomedcentral.com)
  • A study was carried out to investigate the role of the calcitonin gene-related peptide (CGRP) in the regulation of electrolyte transport in the rat and human epididymis. (hku.hk)
  • Calcitonin had no effect on the SCC and did not affect the CGRP-induced rise in the SCC. (hku.hk)
  • Anti-Calcitonin Gene-Related Peptide (CGRP) Therapies: Update on a Previous Review After the American Headache Society 60th Scientific Meeting, San Francisco, June 2018. (jefferson.edu)
  • History and Review of anti-Calcitonin Gene-Related Peptide (CGRP) Therapies: From Translational Research to Treatment. (jefferson.edu)
  • Middle cerebral artery (MCA) diameter is regulated by inherent myogenic activity and the effect of potent vasodilators such as calcitonin gene-related peptide (CGRP). (ku.dk)
  • This assay has high sensitivity and excellent specificity for detection of Calcitonin Gene Related Peptide (CGRP). (cloud-clone.com)
  • No significant cross-reactivity or interference between Calcitonin Gene Related Peptide (CGRP) and analogues was observed. (cloud-clone.com)
  • Matrices listed below were spiked with certain level of recombinant Calcitonin Gene Related Peptide (CGRP) and the recovery rates were calculated by comparing the measured value to the expected amount of Calcitonin Gene Related Peptide (CGRP) in samples. (cloud-clone.com)
  • Intra-assay Precision (Precision within an assay): 3 samples with low, middle and high level Calcitonin Gene Related Peptide (CGRP) were tested 20 times on one plate, respectively. (cloud-clone.com)
  • Inter-assay Precision (Precision between assays): 3 samples with low, middle and high level Calcitonin Gene Related Peptide (CGRP) were tested on 3 different plates, 8 replicates in each plate. (cloud-clone.com)
  • The linearity of the kit was assayed by testing samples spiked with appropriate concentration of Calcitonin Gene Related Peptide (CGRP) and their serial dilutions. (cloud-clone.com)
  • Should the Human Calcitonin Gene Related Peptide (CGRP) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement. (novosides.eu)
  • Description: A competitive inhibition quantitative ELISA assay kit for detection of Human Calcitonin Gene Related Peptide (CGRP) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. (novosides.eu)
  • Description: This is Competitive Enzyme-linked immunosorbent assay for detection of Mouse Calcitonin Gene Related Peptide (CGRP) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids. (novosides.eu)
Adrenomedullin6
  • Following sections of the book deal with the biochemistry, physiology and pharmacology of receptors for the allied peptides amylin and adrenomedullin. (routledge.com)
  • Brain SD, Grant AD (2004) Vascular actions of calcitonin gene-related peptide and adrenomedullin. (springer.com)
  • Adrenomedullin is a vasodilatatory peptide, which is constitutivly produced by endothelial cells and act on the CRLR receptor. (hu-berlin.de)
  • The association of CALCRL with different RAMP proteins produces different receptors which with RAMP1 acts as a receptor for calcitonin-gene-related peptide, with RAMP2 acts as a receptor for adrenomedullin-1and with RAMP3 act as a receptor for adrenomedullin-2. (asdreports.com)
  • However, no significant sequence homology is detected with calcitonin or adrenomedullin. (4adi.com)
  • The calcitonin family of bioactive peptides comprises of calcitonin, amylin, two calcitonin-gene related peptides (CGRP1, and CGRP2) and adrenomedullin (ADM). (4adi.com)
Receptors7
  • The close connections between amylin and calcitonin receptors are highlighted and role of amylin in the regulation of food intake is then considered. (routledge.com)
  • Receptors, Calcitonin Gene-Related Peptide" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)
  • This graph shows the total number of publications written about "Receptors, Calcitonin Gene-Related Peptide" by people in this website by year, and whether "Receptors, Calcitonin Gene-Related Peptide" was a major or minor topic of these publications. (umassmed.edu)
  • Below are the most recent publications written about "Receptors, Calcitonin Gene-Related Peptide" by people in Profiles. (umassmed.edu)
  • SB-(+)-273779 tested at 3 μM had no significant affinity for calcitonin, endothelin, angiotensin II, and α-adrenergic receptors under standard ligand binding assays. (aspetjournals.org)
  • The released peptides bind to specific receptors which cause sensitization. (headacheaustralia.org.au)
  • Critical role of calcitonin gene-related peptide receptors in cortical spreading depression. (painresearchforum.org)
Neuropeptide2
  • Amara SG, Arriza JL, Leff SE, Swanson LW, Evans RM, Rosenfend MG (1985) Expression in brain of a messenger RNA encoding a novel neuropeptide homologous to calcitonin gene related peptide. (springer.com)
  • It is a neuropeptide of 37 amino acids with structural homology to salmon calcitonin . (biology-online.org)
Alpha-Calcitonin gene-re1
  • alpha-Calcitonin gene-related peptide (alphaCGRP) is released mainly from sensory and motor nerves in response to physiological stimuli. (garvan.org.au)
Vasodilator4
  • It is a potent peptide vasodilator and can function in the transmission of nociception. (wikipedia.org)
  • Brain SD, Williams TJ, Tippings JR, Morris HR, MacIntyre I (1985) Calcitonin gene related peptide is a potent vasodilator. (springer.com)
  • 4. The present findings lend further support to the theory of regional variation in the vasodilator response to calcitonin-gene-related peptide in porcine coronary arteries, which seems to be due to different densities of a single type of receptor for calcitonin-gene-related peptide. (clinsci.org)
  • Calcitonin Gene-Related Peptide-I, Human, CAS 90954-53-3, is a potent and long-acting vasodilator. (merckmillipore.com)
Neurons3
  • For either peptide, the key target appears to be the ATP-gated P2X3 receptor that, widely expressed by trigeminal sensory neurons, generates fast, large excitation to release glutamate onto second-order brain neurons. (dovepress.com)
  • The receptor for a peptide found in trigeminal nerve sensory neurons which is a powerful dilator of cerebral and dural arteries. (thefreedictionary.com)
  • Debas, H. T. / A role for calcitonin gene-related peptide-containing neurons in gastric cytoprotection . (elsevier.com)
Immunoreactivity1
  • Batten TF, Lo VK, Maqbool A, McWilliam PN (1989) Distribution of calcitonin gene-related peptide-like immunoreactivity in the medulla oblongata of the cat, in relation to choline acetyltransferase-immunoreactive motoneurones and substance P-immunoreactive fibers. (springer.com)
HUMAN Calcitonin1
  • β-Human calcitonin-gene-related peptide showed higher affinity than α-human calcitonin-gene-related peptide for the binding sites. (clinsci.org)
Polypeptide1
  • Amara SG, Jonas V, Rosenfeld MG, Ong ES, Evans RM (1982) Alternative RNA processing in calcitonin gene expression generates mRNAs encoding different polypeptide products. (springer.com)
Sensory2
  • Increased content and transport of substance P and calcitonin gene-related peptide in sensory nerves innervating inflamed tissue: evidence for a regulatory function of nerve growth factor in vivo. (semanticscholar.org)
  • Low pH-induced release of calcitonin gene-related peptide from capsaicin-sensitive sensory nerves: mechanism of action and biological response. (mysciencework.com)
Monoclonal1
  • Further controlled studies are needed to assess the safety and efficacy of monoclonal calcitonin gene-related peptide antibodies for the preventive treatment of migraine. (elsevier.com)
Endogenous1
  • Pathophysiological roles of endogenous calcitonin gene-related peptide in mouse model of laser induced choroidal neovascularization. (arvojournals.org)
Amino acids2
Pharmacology1
  • The work is aimed at the specialist in the field, but it is hoped that many of the chapters will also prove useful as introductions to those wishing to gain greater familiarity with the biology and pharmacology of these important peptides. (routledge.com)
Antagonist4
  • An infusion of the calcitonin gene-related peptide will induce MIGRAINE and the specific antagonist BIBN 4096 BS is effective in treating an attack of migraine. (thefreedictionary.com)
  • Biohaven Pharmaceutical announced that positive results from a Phase 3 pivotal clinical trial of rimegepant, Biohaven's small molecule calcitonin gene-related peptide receptor antagonist, for the acute treatment of migraine, are published in the July 12, 2019 issue of the New England Journal of Medicine. (thefreedictionary.com)
  • Biohaven Pharmaceutical announced additional safety and preliminary efficacy results from its ongoing long-term, open-label safety study of its oral calcitonin gene-related peptide receptor antagonist, rimegepant. (thefreedictionary.com)
  • Biohaven Pharmaceutical is presenting expanded data from two randomized, pivotal Phase 3 clinical trials of rimegepant, Biohaven's small molecule calcitonin gene-related peptide receptor antagonist, on June 30 at the American Headache Society Annual Scientific Meeting. (thefreedictionary.com)
MRNA2
  • It occurs as a result of alternative processing of mRNA from the calcitonin gene. (jove.com)
  • Calcitonin gene-related peptide and muscle activity regulate acetylcholine receptor alpha-subunit mRNA levels by distinct intracellular pathways. (rupress.org)
Substance1
  • After five days of inflammation, the substance P and calcitonin gene-related peptide content in the sciatic nerve supplying the inflamed paw were increased by 60-75% when compared with the contralateral side. (semanticscholar.org)
Antibodies1
  • Control or blocking peptides are recommended for ELISA plate coating for direct ELISA testing of antibodies or competitive ELISA, and antibody blocking or neutralization. (4adi.com)
Synthesis1
  • Calcitonin gene-related peptide regulates muscle acetylcholine receptor synthesis. (nih.gov)
Pathways1
  • The consequence of migraine gene mutations on relevant migraine pathways has never been tested. (clinicaltrials.gov)
Antagonism1
  • Calcitonin gene-related peptide antagonism and cluster headache: an emerging new treatment. (painresearchforum.org)
Gastric2
  • The exogenous administration of the peptide was able to afford protection against experimental ulcers induced by an increase in gastric secretion. (eurekaselect.com)
  • S. Evangelista, " Role of Calcitonin Gene-Related Peptide in Gastric Mucosal Defence and Healing", Current Pharmaceutical Design (2009) 15: 3571. (eurekaselect.com)
Subarachnoid hemorrhage1
  • Prevention of cerebral vasospasm by calcitonin gene-related peptide slow-release tablet after subarachnoid hemorrhage in monkeys. (biomedsearch.com)
CGRPs1
  • Prophylactic therapy with calcitonin gene‐related peptides (CGRPs) may have unknown fertility consequences for women of child bearing age. (wikipedia.org)
Ischemia2
  • Calcitonin gene-related peptide facilitates revascularization during hindlimb ischemia in mice. (lktlabs.com)
  • Calcitonin gene-related peptide in experimental ischemia. (elsevier.com)
Cluster headache3
  • Calcitonin gene-related peptide in blood: is it increased in the external jugular vein during migraine and cluster headache? (nih.gov)
  • Cluster Headache and Calcitonin Gene-Related Peptide-More on Quantum Therapeutics in Headache Medicine. (painresearchforum.org)
  • Effect of Infusion of Calcitonin Gene-Related Peptide on Cluster Headache Attacks: A Randomized Clinical Trial. (painresearchforum.org)
Responses2
  • Reviewing this growing literature, we have suggested that the BNST participates preferentially in sustained but not phasic threat responses-a pattern complementary to that of the closely related medial division of the central amygdala nucleus. (jneurosci.org)
  • These responses were dose-related. (arvojournals.org)
Receptor called1
  • It works by blocking a receptor called the calcitonin gene-related peptide receptor which plays a critical role in mediating the incapacitating pain of migraine. (thefreedictionary.com)
Thyroid2
  • CT derives from the C cells of the thyroid gland and is the most potent peptide inhibitor of osteoclast-mediated bone resorption. (nih.gov)
  • Calcitonin is 32 aa peptide found in the parafollicular C cells of the thyroid in mammals. (4adi.com)
Affinity1
  • Cell surface proteins that bind CALCITONIN GENE-RELATED PEPTIDE with high affinity and trigger intracellular changes which influence the behavior of cells. (umassmed.edu)
Expression3
  • Changes in the expression of calcitonin gene-related peptide after exposure to stretch-shortening contractions. (cdc.gov)
  • In this study, it can be shown that transduction efficiency of adenoviral-mediated gene transfer into ex vivo-expanded MSCs is dose dependent, transgene expression persists for more than 21 days in culture, and adenoviral transduction does not alter the proliferation or viability of MSCs. (elsevier.com)
  • Previous studies showed that MCAs express KCNQ1, 4, and 5 potassium channel genes, and the expression products (Kv7 channels) participate in the myogenic control of MCA diameter. (ku.dk)
Neurotransmitter1
  • The peptide produces multiple biological effects and has both circulatory and neurotransmitter modes of action. (jove.com)
Hypertension1
  • TY - JOUR T1 - Role of anandamide transporter in regulating calcitonin gene-related peptide production and blood pressure in hypertension. (unboundmedicine.com)
Homologous1
  • A portion of the B-chain of insulin is strongly homologous to these four peptides. (nih.gov)
Antibody1
  • Calcitonin Gene Related Peptide, anti_rat IgG antibody storage GENTAUR recommends for long therm storage to freeze at -24 C. For short time storage up to 30 days we suggest fridge storage at 1 to 10 C. Prevent multiple freeze taw cycles of Calcitonin Gene Related Peptide, anti_rat IgG. (antibody-antibodies.com)
19911
  • Ardvisson U, Ulfhake B, Cullheim S, Terenius L, Hökfelt T (1991) Calcitonin gene-related peptide in the monkey spinal cord and medulla oblongata. (springer.com)
Protein-coupled receptor1
  • Calcitonin Gene Related Peptide Type 1 Receptor (Calcitonin Receptor Like Receptor or CALCRL) - Calcitonin receptor-like (CALCRL) also known as the calcitonin receptor-like receptor (CRLR) is a G protein-coupled receptor. (asdreports.com)
Coronary artery2
  • Most of the specific binding sites for both peptides in the large coronary artery were localized in the intima and media. (clinsci.org)
  • This peptide inhibits retinal apoptosis in retinal cells in animal models of coronary artery occlusion. (lktlabs.com)
Inhibits1
  • Calcitonin gene-related peptide inhibits Langerhans cell-mediated HIV-1 transmission. (inserm.fr)
A historical perspective on the role of sensory nerves in neurogenic inflammation | SpringerLink
A historical perspective on the role of sensory nerves in neurogenic inflammation | SpringerLink (link.springer.com)
Calcitonin Gene-related Peptide Levels in Chronic Migraine - Full Text View - ClinicalTrials.gov
Calcitonin Gene-related Peptide Levels in Chronic Migraine - Full Text View - ClinicalTrials.gov (clinicaltrials.gov)
The CGRP Family: Calcitonin Gene-Related Peptide (CGRP), Amylin and Ad
The CGRP Family: Calcitonin Gene-Related Peptide (CGRP), Amylin and Ad (routledge.com)
Most Popular Articles : PAIN
Most Popular Articles : PAIN (journals.lww.com)
NIOSHTIC-2 Publications Search - 20039032 - Changes in the expression of calcitonin gene-related peptide after exposure to...
NIOSHTIC-2 Publications Search - 20039032 - Changes in the expression of calcitonin gene-related peptide after exposure to... (cdc.gov)
The role of peptides in bone healing and regeneration: a systematic review | BMC Medicine | Full Text
The role of peptides in bone healing and regeneration: a systematic review | BMC Medicine | Full Text (bmcmedicine.biomedcentral.com)
What is the role of calcitonin gene-related peptide (CGRP) in the pathogenesis of anaphylaxis?
What is the role of calcitonin gene-related peptide (CGRP) in the pathogenesis of anaphylaxis? (medscape.com)
Dural Calcitonin Gene-Related Peptide Produces Female-Specific Responses in Rodent Migraine Models | Journal of Neuroscience
Dural Calcitonin Gene-Related Peptide Produces Female-Specific Responses in Rodent Migraine Models | Journal of Neuroscience (jneurosci.org)
FDA-Approved Prescription Medications to Prevent Migraine
FDA-Approved Prescription Medications to Prevent Migraine (verywellhealth.com)
Neuropeptide regulation of adaptive immunity in the tibia fracture model of complex regional pain syndrome | SpringerLink
Neuropeptide regulation of adaptive immunity in the tibia fracture model of complex regional pain syndrome | SpringerLink (link.springer.com)
Antler development and coupled osteoporosis in the skeleton of red deer Cervus elaphus: expression dynamics for regulatory and...
Antler development and coupled osteoporosis in the skeleton of red deer Cervus elaphus: expression dynamics for regulatory and... (link.springer.com)
The Enteric Nervous System and Gastrointestinal Innervation: Integrated Local and Central Control | SpringerLink
The Enteric Nervous System and Gastrointestinal Innervation: Integrated Local and Central Control | SpringerLink (link.springer.com)
Distribution of substance P and the calcitonin gene-related peptide in the human tensor tympani muscle | SpringerLink
Distribution of substance P and the calcitonin gene-related peptide in the human tensor tympani muscle | SpringerLink (link.springer.com)
Migraine: MedlinePlus Medical Encyclopedia
Migraine: MedlinePlus Medical Encyclopedia (medlineplus.gov)
What is the pathogenesis of pediatric migraine headache?
What is the pathogenesis of pediatric migraine headache? (medscape.com)
Pharmacological Rescue of Cortical Synaptic and Network Potentiation in a Mouse Model for Fragile X Syndrome |...
Pharmacological Rescue of Cortical Synaptic and Network Potentiation in a Mouse Model for Fragile X Syndrome |... (nature.com)
June 2001 - Volume 97 - Issue 6 : Obstetrics & Gynecology
June 2001 - Volume 97 - Issue 6 : Obstetrics & Gynecology (journals.lww.com)
Involvement of Cytokines in Lipopolysaccharide-Induced Facilitation of CGRP Release from Capsaicin-Sensitive Nerves in the...
Involvement of Cytokines in Lipopolysaccharide-Induced Facilitation of CGRP Release from Capsaicin-Sensitive Nerves in the... (jneurosci.org)
IJMS | Free Full-Text | Novel Potentials of the DPP-4 Inhibitor Sitagliptin against Ischemia-Reperfusion (I/R) Injury in Rat...
IJMS | Free Full-Text | Novel Potentials of the DPP-4 Inhibitor Sitagliptin against Ischemia-Reperfusion (I/R) Injury in Rat... (mdpi.com)
Compound Report Card
Compound Report Card (ebi.ac.uk)
What Is the Best Thing to Do for a Migraine?
What Is the Best Thing to Do for a Migraine? (medicinenet.com)
Migraine Headache Treatment & Management: Approach Considerations, Emergency Department Considerations, Reduction of Migraine...
Migraine Headache Treatment & Management: Approach Considerations, Emergency Department Considerations, Reduction of Migraine... (emedicine.medscape.com)
Plus it
Plus it (jneurosci.org)
International Union of Pharmacology. LXIX. Status of the Calcitonin Gene-Related Peptide Subtype 2 Receptor | Pharmacological...
International Union of Pharmacology. LXIX. Status of the Calcitonin Gene-Related Peptide Subtype 2 Receptor | Pharmacological... (pharmrev.aspetjournals.org)
Pharmacology of SB-273779, a Nonpeptide Calcitonin Gene-Related Peptide 1 Receptor Antagonist | Journal of Pharmacology and...
Pharmacology of SB-273779, a Nonpeptide Calcitonin Gene-Related Peptide 1 Receptor Antagonist | Journal of Pharmacology and... (jpet.aspetjournals.org)
Håvard Jenssen - Research Output - Roskilde University Research Portal
Håvard Jenssen - Research Output - Roskilde University Research Portal (forskning.ruc.dk)
Calcitonin Gene Related Peptide - Pipeline Review, H2 2020
Calcitonin Gene Related Peptide - Pipeline Review, H2 2020 (marketresearch.com)