Calcitonin Gene-Related Peptide
Calcitonin gene-related peptide. A 37-amino acid peptide derived from the calcitonin gene. It occurs as a result of alternative processing of mRNA from the calcitonin gene. The neuropeptide is widely distributed in neural tissue of the brain, gut, perivascular nerves, and other tissue. The peptide produces multiple biological effects and has both circulatory and neurotransmitter modes of action. In particular, it is a potent endogenous vasodilator.
Calcitonin
Bethanechol
Substance P
Neuropeptide Y
A 36-amino acid peptide present in many organs and in many sympathetic noradrenergic neurons. It has vasoconstrictor and natriuretic activity and regulates local blood flow, glandular secretion, and smooth muscle activity. The peptide also stimulates feeding and drinking behavior and influences secretion of pituitary hormones.
Neuropeptides
Nerve Fibers
Vasoactive Intestinal Peptide
Peptides
Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.
Receptors, Calcitonin
Receptors, Calcitonin Gene-Related Peptide
Cell surface proteins that bind CALCITONIN GENE-RELATED PEPTIDE with high affinity and trigger intracellular changes which influence the behavior of cells. CGRP receptors are present in both the CENTRAL NERVOUS SYSTEM and the periphery. They are formed via the heterodimerization of the CALCITONIN RECEPTOR-LIKE PROTEIN and RECEPTOR ACTIVITY-MODIFYING PROTEIN 1.
Peptide Fragments
RNA, Messenger
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Calcitonin Receptor-Like Protein
A receptor protein that is associated with RECEPTOR ACTIVITY-MODIFYING PROTEINS. When bound to RECEPTOR ACTIVITY-MODIFYING PROTEIN 1 it forms the CALCITONIN GENE-RELATED RECEPTOR. When bound to RECEPTOR ACTIVITY-MODIFYING PROTEIN 2 or RECEPTOR ACTIVITY-MODIFYING PROTEIN 3 it forms the ADRENOMEDULLIN RECEPTOR.
FMRFamide
Base Sequence
Amino Acid Sequence
Genes
Blotting, Southern
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Peptide Library
Parathyroid Hormone-Related Protein
A ubiquitously expressed, secreted protein with bone resorption and renal calcium reabsorption activities that are similar to PARATHYROID HORMONE. It does not circulate in appreciable amounts in normal subjects, but rather exerts its biological actions locally. Overexpression of parathyroid hormone-related protein by tumor cells results in humoral calcemia of malignancy.
Peptide PHI
A 27-amino acid peptide with histidine at the N-terminal and isoleucine amide at the C-terminal. The exact amino acid composition of the peptide is species dependent. The peptide is secreted in the intestine, but is found in the nervous system, many organs, and in the majority of peripheral tissues. It has a wide range of biological actions, affecting the cardiovascular, gastrointestinal, respiratory, and central nervous systems.
Transcription, Genetic
Bombesin
Receptors, Cholinergic
Cell surface proteins that bind acetylcholine with high affinity and trigger intracellular changes influencing the behavior of cells. Cholinergic receptors are divided into two major classes, muscarinic and nicotinic, based originally on their affinity for nicotine and muscarine. Each group is further subdivided based on pharmacology, location, mode of action, and/or molecular biology.
PubMed
A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.
Myasthenia Gravis
A disorder of neuromuscular transmission characterized by weakness of cranial and skeletal muscles. Autoantibodies directed against acetylcholine receptors damage the motor endplate portion of the NEUROMUSCULAR JUNCTION, impairing the transmission of impulses to skeletal muscles. Clinical manifestations may include diplopia, ptosis, and weakness of facial, bulbar, respiratory, and proximal limb muscles. The disease may remain limited to the ocular muscles. THYMOMA is commonly associated with this condition. (Adams et al., Principles of Neurology, 6th ed, p1459)
Anaphylaxis
Receptor Activity-Modifying Proteins
Sterilization, Tubal
Migraine Disorders
A class of disabling primary headache disorders, characterized by recurrent unilateral pulsatile headaches. The two major subtypes are common migraine (without aura) and classic migraine (with aura or neurological symptoms). (International Classification of Headache Disorders, 2nd ed. Cephalalgia 2004: suppl 1)
Ethinyl Estradiol
Levonorgestrel
Insulin
A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1).
Glucose
Islet Amyloid Polypeptide
A pancreatic beta-cell hormone that is co-secreted with INSULIN. It displays an anorectic effect on nutrient metabolism by inhibiting gastric acid secretion, gastric emptying and postprandial GLUCAGON secretion. Islet amyloid polypeptide can fold into AMYLOID FIBRILS that have been found as a major constituent of pancreatic AMYLOID DEPOSITS.
Insulin Resistance
Cluster Headache
A primary headache disorder that is characterized by severe, strictly unilateral PAIN which is orbital, supraorbital, temporal or in any combination of these sites, lasting 15-180 min. occurring 1 to 8 times a day. The attacks are associated with one or more of the following, all of which are ipsilateral: conjunctival injection, lacrimation, nasal congestion, rhinorrhea, facial SWEATING, eyelid EDEMA, and miosis. (International Classification of Headache Disorders, 2nd ed. Cephalalgia 2004: suppl 1)
Headache
Headache Disorders, Primary
Meninges
Nociceptors
Peripheral AFFERENT NEURONS which are sensitive to injuries or pain, usually caused by extreme thermal exposures, mechanical forces, or other noxious stimuli. Their cell bodies reside in the DORSAL ROOT GANGLIA. Their peripheral terminals (NERVE ENDINGS) innervate target tissues and transduce noxious stimuli via axons to the CENTRAL NERVOUS SYSTEM.
Trigeminal Ganglion
Calcitonin gene-related peptide decreases expression of acetylcholinesterase in mammalian myotubes. (1/1567)
Nerve-derived trophic factors are known to modulate expression of acetylcholinesterase (AChE) in skeletal muscle fibers, yet the precise identity of these factors remains elusive. In the present study, we treated mouse C2 myotubes with calcitonin gene-related peptide (CGRP). Compared to non-treated myotubes, cell-associated AChE activity levels were decreased by approximately 60% after 48 h of treatment. A parallel reduction in AChE total protein levels was also observed as determined by Western blot analysis. The reduction in AChE activity was due to a decrease in the levels of the G1 molecular form and to an elimination of G1. By contrast, levels of secreted AChE remained unchanged following CGRP treatment. Finally, the overall decrease in AChE activity was accompanied by a reduction in AChE transcripts which could not be attributed to changes in the transcriptional rate of the ACHE gene. (+info)Interaction of amylin with calcitonin gene-related peptide receptors in the microvasculature of the hamster cheek pouch in vivo. (2/1567)
1. This study used intravital microscopy to investigate the receptors stimulated by amylin which shares around 50% sequence homology with the vasodilator calcitonin gene-related peptide (CGRP) in the hamster cheek pouch microvasculature in vivo. 2. Receptor agonists dilated arterioles (diameters 20-40 microm). The -log of the concentrations (+/- s.e.mean; n = 8) causing 50% increase in arteriole diameter were: human betaCGRP (10.8 +/- 0.3), human alphaCGRP (10.8 +/- 0.4), rat alphaCGRP (10.4 +/- 0.3). Rat amylin and the CGRP2 receptor selective agonist [Cys(ACM2,7]-human alphaCGRP were 100 fold less potent (estimates were 8.5 +/- 0.4 and 8.2 +/- 0.3 respectively). 3. The GCRP1 receptor antagonist, CGRP8-37 (300 nmol kg(-1); i.v.) reversibly inhibited the increase in diameter evoked by human alphaCGRP (0.3 nM) from 178 +/- 22% to 59 +/- 12% (n = 8; P < 0.05) and by rat amylin (100 nM) from 138 +/- 23% to 68 +/- 24% (n = 6; P < 0.05). CGRP8-37 did not inhibit vasodilation evoked by substance P (10 nM; n = 4: P > 0.05). 4. The amylin receptor antagonist, amylin8-37 (300 nmol kg(-1); i.v.) did not significantly inhibit the increase in diameter evoked by human alphaCGRP (0.3 nM) which was 112 +/- 26% in the absence, and 90 +/- 29% in the presence of antagonist (n = 4; P < 0.05); nor that evoked by rat amylin (100 nM) which was 146 +/- 23% in the absence and 144 +/- 32% in the presence of antagonist (n = 4; P > 0.05). 5. The agonist profile for vasodilatation and the inhibition of this dilatation by CGRP8-37, although not the amylin8-37 indicates that amylin causes vasodilatation through interaction with CGRP1 receptors in the hamster cheek pouch. (+info)Neurogenic origin of articular hyperemia in early degenerative joint disease. (3/1567)
It has been speculated that joint instability resulting from anterior cruciate ligament (ACL) rupture could be exacerbated by changes in vasomotor activity in the remaining supporting structures. In this study, the effect of ACL transection on medial collateral ligament (MCL) basal perfusion and its responsiveness to calcitonin gene-related peptide (CGRP) and sympathetic adrenergic influences was examined. Using urethan-anesthetized rabbits, we tested the effects of CGRP and its antagonist CGRP-(8-37) by topical application of these agents to the exposed knee while sympathetic influences were tested by electrically stimulating the saphenous nerve. It was found that MCL basal perfusion was elevated in ACL-sectioned joints; however, this effect was abrogated by prior resection of the articular nerve supply. At the doses tested, the normal vasodilator response to CGRP was abolished in ACL-sectioned joints, whereas the response to CGRP-(8-37) was attenuated. Even under the influence of increased constrictor tone, MCL and capsule blood vessels still showed substantially reduced responses to exogenous CGRP administration. By contrast, nerve-mediated constrictor responses were mostly unaffected by joint instability. This study suggests that posttraumatic knee joint hyperemia is neurogenically mediated, possibly by increased secretion of CGRP. (+info)Attenuation of myocardial injury due to oxygen free radicals (OFR) by pretreatment with OFR or calcitonin gene-related peptide. (4/1567)
AIM: To study the cardioprotective effects of oxygen free radicals (OFR) and calcitonin gene-related peptide (OGRP) pretreatment on myocardial damages due to OFR in isolated perfused rat heart. METHODS: The hearts were perfused in a Langendorff mode. OFR were generated by electrolysis of Krebs-Henseleit (K-H) solution. RESULTS: OFR pretreatment reduced the impairment of cardiac contractile function, the decrease of coronary flow and the increase of creatinine kinase (CK) release due to OFR, and the effect exhibited period dependence and cycle-dependence. 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine (H-7), an inhibitor of protein kinase C, abolished the protection of OFR pretreatment (CK release = 110 +/- 7, 215 +/- 23, 169 +/- 14, 240 +/- 30, and 113 +/- 19 kU.L-1 for control, OFR, OFR pretreatment, OFR pretreatment plus H-7, and H-7, respectively). CGRP pretreatment also protected the myocardium damages elicited by OFR in isolated perfused rat heart. CONCLUSIONS: OFR or CGRP pretreatment protected myocardium against injury elicited by OFR, and the effect of OFR pretreatment was related to the activation of PKC. (+info)Trigeminal nerve ganglion stimulation-induced neurovascular reflexes in the anaesthetized cat: role of endothelin(B) receptors in carotid vasodilatation. (5/1567)
1. The effects of intravenous administration of endothelin (ET) receptor antagonists SB-209670 (0.001-10.0 mg kg(-1)), SB-217242, SB-234551 (0.01-10.0 mg kg(-1)) and BQ-788 (0.001-1.0 mg kg(-1)) were investigated on trigeminal nerve ganglion stimulation-induced neurovascular reflexes in the carotid vasculature of the anaesthetized cat. Comparisons were made with sumatriptan (0.003-3.0 mg kg(-1)) and alpha-CGRP8-37 (0.001-0.1 mg kg(-1)). 2. Trigeminal nerve ganglion stimulation produced frequency related increases in carotid blood flow, reductions in carotid vascular resistance and non-frequency related increases in blood pressure. Guanethidine (3 mg kg(-1), i.v.) blocked trigeminal nerve ganglion-induced increases in blood pressure but had no effect on changes in carotid flow or resistance. Maximal reductions in carotid vascular resistance was observed at 10 Hz, and this frequency was selected to investigate the effects of drugs on trigeminal nerve ganglion stimulation-induced responses in guanethidine treated cats. 3. Saline, alpha-CGRP8-37 SB-209670 and BQ-788 had little or no effect on resting haemodynamic parameters. SB-217242 (10 mg kg(-1), n=3) produced a 56% reduction in arterial blood pressure whereas SB-233451 (10 mg kg(-1), n=3) produced a 30% reduction in carotid vascular resistance. Sumatriptan produced dose-related reductions in resting carotid flow and increases (max. 104% at 0.3 mg kg(-1), n = 5) in vascular resistance. 4. SB-209670 (n=6-7), SB-217242 (n=3) and BQ-788 (n=3) produced inhibition of trigeminal nerve ganglion stimulation-induced reductions in carotid vascular resistance. Saline, SB-234551, alpha-CGRP8-37 and sumatriptan had no effect. 5. These data demonstrate ET(B) receptor blockade attenuates the vasodilator effects of trigeminal nerve ganglion stimulation in the carotid vascular bed of guanethidine pretreated anaesthetized cats. (+info)Depletion of cutaneous peptidergic innervation in HIV-associated xerosis. (6/1567)
Severe xerosis occurs in approximately 20% of human immunodeficiency virus seropositive patients. Changes in cutaneous innervation have been found in various inflammatory skin diseases and in xerotic skin in familial amyloid. We have therefore carried out a quantitative examination of the cutaneous peptidergic innervation in human immunodeficiency virus-associated xerosis. Immunohistochemistry and image analysis quantitation were used to compare total cutaneous innervation (protein gene product 9.5), calcitonin gene-related peptide, substance P, and vasoactive intestinal peptide peptidergic fibers, at two sites in the skin of human immunodeficiency virus-associated xerosis patients (upper arm, n = 12; upper leg, n = 11) and site-matched seronegative controls (upper arm, n = 10; upper leg, n = 10). Measurement of lengths of fibers of each type was carried out for each subject in the epidermis and papillary dermis, and around the sweat glands. Immunostained mast cells in these areas were counted. Epidermal integrity and maturation were assessed by immunostaining for involucrin. There were significant (Mann-Whitney U test; p < 0.02) decreases in total lengths of protein gene product 9.5 fibers in both epidermis/papillary dermis and sweat gland fields; of calcitonin gene-related peptide innervation in the epidermis/papillary dermis; and of substance P innervation of the sweat glands. There were no differences in the distribution of mast cells, or in the epidermal expression of involucrin. Depletion of the calcitonin gene-related peptide innervation may affect the nutrient blood supply of the upper dermis, and the integrity and function of basal epidermis and Langerhans cells. Diminished substance P innervation of the sweat glands may affect their secretory activity. Both of these changes may be implicated in the development of xerosis. (+info)Decreased CGRP, but preserved Trk A immunoreactivity in nerve fibres in inflamed human superficial temporal arteries. (7/1567)
The peptidergic sensory innervation of cranial blood vessels may play an important part in vascular head pain. The neuropeptides calcitonin gene-related peptide (CGRP) and substance P in sensory fibres are dependent on nerve growth factor (NGF) produced by the blood vessels, and when released from nerve terminals mediate neurogenic inflammation. NGF is increased in inflamed tissues, and acts via its high affinity receptor trk A on nociceptor fibres to produce hyperalgesia. CGRP and trk A immunoreactive nerve fibres have therefore been studied, for the first time, in inflamed (n=7) and non-inflamed (n=10) temporal arteries biopsied from patients with headache and suspected giant cell arteritis. CGRP immunoreactivity was markedly decreased to absent in adventitial nerve fibres in inflamed regions of vessels, which may reflect secretion from nerve terminals, as CGRP immunoreactivity could still be seen in nerve trunks in periadventitial tissue. Trk A immunoreactive nerve fibres were found in a similar distribution to CGRP containing nerve fibres in non-inflamed vessels, and the trk A immunoreactivity was virtually unchanged in inflamed vessels. The evidence supports a role for NGF related mechanisms in inflammatory vascular head pain. Anti-NGF or anti-trk A agents may represent novel analgesics in this condition. (+info)Calcitonin gene-related peptide rapidly downregulates nicotinic receptor function and slowly raises intracellular Ca2+ in rat chromaffin cells in vitro. (8/1567)
Although calcitonin gene-related peptide (CGRP) modulates muscle-type nicotinic acetylcholine receptors (nAChRs) via intracellular second messenger-mediated phosphorylation, the action of this peptide on neuronal-type nAChRs remains unknown. Using neuronal nAChRs of rat chromaffin cells in vitro we studied the effect of CGRP, which is physiologically present in adrenal medulla, on membrane currents and [Ca2+]i transients elicited by nicotine. Our main novel observation was that CGRP (either bath-applied or focally applied for a few seconds or even co-applied with nicotine for a few milliseconds) selectively and rapidly blocked nAChRs (a phenomenon unlikely caused by intracellular messengers in view of its speed) without affecting GABA receptors. The inhibitory effect of CGRP was independent of [Ca2+]i or membrane potential and not accompanied by baseline current changes. Like the competitive antagonist N,N,N-trimethyl-1-(4-trans-stilbenoxy)-2-propilammonium, CGRP induced a rightward, parallel shift of the nicotine dose-response curve; during co-application of these blockers the nicotine dose-ratio value was the sum of the values obtained with each antagonist alone. The block by CGRP was insensitive to the receptor antagonist hCGRP8-37 but mimicked by CGRP1-7. Persistent application of CGRP slowly increased [Ca2+]i, a phenomenon independent from external Ca2+, thus implying Ca2+ release from internal stores, and suppressed by hCGRP8-37. CGRP1-7 had no significant effect on [Ca2+]i. We propose that the 1-7 amino acid sequence of CGRP was responsible for the direct, rapid block of nAChRs, whereas the full-length peptide molecule was necessary for the delayed rise in internal Ca2+ potentially able to trigger phosphorylation-dependent modulation of nicotinic receptor function. (+info)
Quantitative autoradiography reveals higher densities of specific calcitonin-gene-related peptide receptors in small...
Origins of substance P- and calcitonin gene-related peptide-containing nerves in the internal carotid artery of rat
Distinct substance P and calcitonin gene-related peptide immunoreactive nerves in the guinea pig eye. | IOVS | ARVO Journals
Sensory nerve terminal activity in severe hypertension as reflected by circulating calcitonin gene-related peptide (CGRP) and...
Topical Calcitonin Gene-Related Peptide Increases Wound Closure in Sec by Darin Thomas Dieckhoff
Calcitonin gene-related peptide enhances release of native brain-derived neurotrophic factor from trigeminal ganglion neurons<...
Regulation of calcitonin gene-related peptide gene expression by a met by Amanda C. Herbster
Calcitonin gene-related peptide in experimental ischemia. Implication of an endogenous anti-ischemic effect<...
Engineering ex vivo-expanded marrow stromal cells to secrete calcitonin gene-related peptide using adenoviral vector<...
Activin and bone morphogenetic proteins induce calcitonin gene-related peptide in embryonic sensory neurons in vitro
Activation of calcitonin gene-related peptide signaling through the prostaglandin E2-EP1/EP2/EP4 receptor pathway in synovium...
Effects of glyceryl trinitrate and calcitonin-gene-related peptide on BOLD signal and arterial diameter -methodological studies...
Characterization of the human calcitonin-gene-related peptide receptor | Biochemical Society Transactions
What is the role of calcitonin gene-related peptide (CGRP) in the pathogenesis of anaphylaxis?
CLIA Kit for Calcitonin Gene Related Peptide (CGRP) | CCA876Ra | Rattus norvegicus (Rat) CLOUD-CLONE CORP.(CCC)
Plus it
NIOSHTIC-2 Publications Search - 20039032 - Changes in the expression of calcitonin gene-related peptide after exposure to...
Calcitonin Gene Products: Molecular Biology, Chemistry, and Actions | Springer for Research & Development
Role of CGRP-Receptor Component Protein (RCP) in CLR/RAMP Function | Bentham Science
Amylin calcitonin gene related peptide and adrenomedullin a superfamil
Calcitonin gene-related peptide does not excite or sensitize meningeal nociceptors: Implications for the pathophysiology of...
Calcitonin Gene Related Peptide (CGRP) - Pipeline Review, H2 2019 - Global Markets Directs
Phosphodiesterases 3 and 5 express activity in the trigeminal ganglion and co-localize with calcitonin gene-related peptide -...
CGRP elisa kit | Fish Calcitonin Gene Related Peptide ELISA Kit-NP 001095943.1
Calcitonin gene-related peptide and muscle activity regulate acetylcholine receptor alpha-subunit mRNA levels by distinct...
Calcitonin Gene Related Peptide : Severn Biotech, Limited
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Leicester Research Archive: Depletion of substance P and calcitonin gene-related peptide in sciatic nerve of rats with...
PRIME PubMed | Role of anandamide transporter in regulating calcitonin gene-related peptide production and blood pressure in...
Papers with the keyword Intracranial Haemorrage | Read by QxMD
Ian M. Dickerson, Ph.D. - University of Rochester Medical Center
RAMP3 receptor activity modifying protein 3 [Homo sapiens (human)] - Gene - NCBI
Iain MacIntyre. 30 August 1924 - 18 September 2008 | Biographical Memoirs of Fellows of the Royal Society
Detailed Information (TTD) -- BIDD
Abstract 820: Autoregulation of CGRP Expression via β2-Adrenoreceptor Signaling in Intrinsic Cardiac Adrenergic Cells |...
Sensory hypoinnervation in club foot by M Ahmed, N Ahmed et al.
Purification and characterization of a peptide from amyloid-rich pancreases of type 2 diabetic patients | PNAS
Baum, O<...
Calcitonin Gene-Related Peptide in the Bed Nucleus of the Stria Terminalis Produces an Anxiety-Like Pattern of Behavior and...
siRNA, DsiRNA and Plasmid Transfection Efficiency: Raf-1- selective siRNA and Response to Pain
RePub, Erasmus University Repository:
Long-lasting physiological antagonism of calcitonin gene-related peptide towards...
Rapid Communication: Salt-Sensitive Hypertension Induced by Sensory Denervation | Hypertension
ORBi: Browsing ORBi
Einfluss von Calcitonin Gene-Related Peptide und Substance P auf die mRNA-Expression und Freisetzung von Zytokinen aus...
TumorPortal
Prevention of stress- or nitric oxide donor-induced medication overuse headache by a calcitonin gene-related peptide antibody...
Dietary Sodium Loading Increases Arterial Pressure in Afferent Renal-Denervated Rats | Hypertension
Expression of calcitonin gene-related peptide in the infrapatellar fat pad in knee osteoarthritis patients | Journal of...
The New Era Of Disease Modifying Migraine Drugs (DMMDs) - On Health
Characterization of CGRP protein expression in satellite-like cells and dendritic arbours of the mouse olfactory bulb
CGRP-induced light aversion in a preclinical migraine model - Andrew Russo
Ultra-high field MR angiography in human migraine models: a 3.0 T/7.0 T comparison study | The Journal of Headache and Pain |...
Critical role of calcitonin gene-related peptide receptors in cortical spreading depression. | Pain Research Forum
Acupuncture for Relief of Angina | Circulation
Role of ATP-sensitive K<sup>+</sup> channels in CGRP-induced dilatation of basilar artery...
Calcitonin Related Peptides
Papers with the keyword Gepants | Read by QxMD
Aston Publications Explorer
Inhibition of inflammatory pain by activating B-type natriuretic peptide signal pathway in nociceptive sensory neurons | Read...
IJMS | Free Full-Text | Novel Potentials of the DPP-4 Inhibitor Sitagliptin against Ischemia-Reperfusion (I/R) Injury in Rat...
Further studies on the mode of action of calcitonin on isolated rat osteoclasts: pharmacological evidence for a second site...
Calcitonin gene-related peptide antagonism and cluster headache: an emerging new treatment. | Pain Research Forum
Yeni ÇIKAN ELISA Kitleri
Calcitonin Gene-related Peptide Levels in Chronic Migraine - Full Text View - ClinicalTrials.gov
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Up-regulation of substance P in low-threshold myelinated afferents is not required for tactile allodynia in the chronic...
Upregulation of substance P in low-threshold myelinated afferents is not required for tactile allodynia in the chronic...
CGRP antibodies & migraine - findings so far - Migraine
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New players in the preventive treatment of migraine.
Olcegepant - DrugBank
Citation tools | Neurology Clinical Practice
Sensory nerves in the interface membrane of aseptic loose hip prostheses
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Pa cv engl.doc
Eptinezumab
November 2014). "Safety and efficacy of ALD403, an antibody to calcitonin gene-related peptide, for the prevention of frequent ... Other anti-migraine antibodies blocking the calcitonin gene-related peptide (CGRP) pathway *Erenumab ... It is a monoclonal antibody that targets calcitonin gene-related peptides (CGRP) alpha and beta.[3][4] It is administered by ... This analgesic-related article is a stub. You can help Wikipedia by expanding it. ...
S100A12
Maayan C, Becker Y, Gesundheit B, Girgis SI (2002). "Calcitonin gene related peptide in familial dysautonomia". Neuropeptides. ... April 1996). "Human CAAF1 gene--molecular cloning, gene structure, and chromosome mapping". Biochemical and Biophysical ... gene, a new member of the S100 gene cluster on chromosome 1q21". Cell Calcium. 20 (6): 459-64. doi:10.1016/S0143-4160(96)90087- ... gene, a new member of the S100 gene cluster on chromosome 1q21". Cell Calcium. 20 (6): 459-64. doi:10.1016/S0143-4160(96)90087- ...
Susan Brain
Brain, S. D.; Williams, T. J.; Tippins, J. R.; Morris, H. R.; MacIntyre, I. (1985). "Calcitonin gene-related peptide is a ... In her early career she discovered the Calcitonin gene-related peptide receptor antagonist (CGRP) as a potent microvascular ... More recently her research found that the gene TRPC5 can help protect against pain in arthritis and that the gene TRPA1 is ...
Neurotransmission
ACh-vasoactive intestinal peptide (VIP) co-release. ACh-calcitonin gene-related peptide (CGRP) co-release. Glutamate-dynorphin ... For example, striatal "GABAergic neurons" utilize opioid peptides or substance P as their primary cotransmitter. Some neurons ...
CALCRL
... it is a receptor for calcitonin gene-related peptide. The protein encoded by the CALCRL gene is a G protein-coupled receptor ... 2004). "Calcitonin gene-related peptide and its role in migraine pathophysiology". Eur J Pharmacol. 500 (1-3): 315-30. doi: ... Calcitonin gene-related peptide receptor antagonists are approved for the treatment of migraine. GRCh38: Ensembl release 89: ... 2003). "Calcitonin gene-related peptide in pregnancy and its emerging receptor heterogeneity". Trends Endocrinol. Metab. 13 (6 ...
Migraine
Calcitonin gene related peptides (CGRPs) have been found to play a role in the pathogenesis of the pain associated with ... CGRP receptor antagonists target calcitonin gene-related peptide or its receptor to prevent migraine headaches or reduce their ... Cite journal requires ,journal= (help) Loder E, Renthal W (March 2019). "Calcitonin Gene-Related Peptide Monoclonal Antibody ... Medications in the anti-calcitonin gene-related peptide, including eptinezumab, erenumab, fremanezumab, and galcanezumab, ...
Debbie Lucy Hay
"Regulation of signal transduction by calcitonin gene-related peptide receptors." Trends in Pharmacological Sciences 31, no. 10 ... "Pharmacological discrimination of calcitonin receptor: receptor activity-modifying protein complexes." Molecular Pharmacology ... Investigation of the calcitonin receptor-like receptor and receptor activity modifying proteins' at Imperial College London. ...
Ubrogepant
It is the first drug in the class of oral calcitonin gene-related peptide receptor antagonists approved for the acute treatment ... It is a small-molecule calcitonin gene-related peptide receptor antagonist. The effectiveness of ubrogepant for the acute ...
AKTIP
"A cDNA encoding the calcitonin gene-related peptide type 1 receptor". J Biol Chem. 271 (19): 11325-9. doi:10.1074/jbc.271.19. ... Lesche R, Peetz A, van der Hoeven F, Rüther U (1998). "Ft1, a novel gene related to ubiquitin-conjugating enzymes, is deleted ... AKT-interacting protein is a protein that in humans is encoded by the AKTIP gene. The mouse homolog of this gene produces fused ... This gene may play a role in apoptosis as these morphological abnormalities are caused by altered patterns of programmed cell ...
Neurogenic inflammation
The calcitonin gene-related peptide (CGRP) is a therapeutic target in migraine because of its hypothesized role in mediating ... In turn, histamine evokes the release of substance P and calcitonin gene-related peptide; thus, a bidirectional link between ... Durham PL, Vause CV (July 2010). "Calcitonin gene-related peptide (CGRP) receptor antagonists in the treatment of migraine". ... Calcitonin Gene-Related Peptide (CGRP), neurokinin A (NKA), and endothelin-3 (ET-3). In such neurons, release of these pro- ...
Fremanezumab
It is in the calcitonin gene-related peptide antagonist class of medications. It was approved for medical use in the United ... Fremanezumab is a fully humanized monoclonal antibody directed against calcitonin gene-related peptides (CGRP) alpha and beta. ... Like other proteins, the substance is degraded by proteolysis to small peptides and amino acids, which are reused or excreted ...
Rimegepant
... is a small molecule calcitonin gene-related peptide (CGRP) receptor antagonist. Originally discovered at Bristol- ...
Iain Macintyre
Along with H. R. Morris he isolated and sequenced calcitonin gene-related peptide. Later research centred on the role played by ... His team also demonstrated calcitonin gene-related peptide, which they went on to sequence and then characterise. A major ... "The myotropic and plasma-calcium modulating effects of calcitonin gene-related peptide (CGRP)". Neuropeptides. 4 (5): 425-434. ... Macintyre's laboratory also purified and then sequenced both porcine calcitonin and human calcitonin. ...
Development of the endocrine system
This stage is regulated by androgens, the genitofemoral nerve, and calcitonin gene-related peptide. During the second and third ... Studies of gene expression show that a specific complement of genes, such as follistatin and multiple cyclin kinase inhibitors ... Studies in mice have shown that interfering with the HOX15 gene can cause parathyroid gland aplasia, which suggests the gene ... Malformations in the GCM2 gene have resulted in hypoparathyroidism. Studies on SOX3 gene mutations have demonstrated that it ...
Parafollicular cell
Kameda Y (October 1987). "Localization of immunoreactive calcitonin gene-related peptide in thyroid C cells from various ... Parafollicular cells secrete calcitonin, a hormone that participates in the regulation of calcium metabolism. Calcitonin lowers ... The primary function of these cells is to secrete calcitonin. They are located adjacent to the thyroid follicles and reside in ... Gkonos PJ, Tavianini MA, Liu CC, Roos BA (December 1989). "Thyrotropin-releasing hormone gene expression in normal thyroid ...
Erenumab
... , sold under the brand name Aimovig, is a medication which targets the calcitonin gene-related peptide receptor (CGRPR ... Erenumab is a fully human monoclonal antibody blocking the calcitonin gene-related peptide receptor (CGRPR). After subcutaneous ... Other anti-migraine antibodies blocking the calcitonin gene-related peptide (CGRP) pathway: Eptinezumab Fremanezumab ... Like other proteins, the substance is degraded by proteolysis to small peptides and amino acids. It has an elimination half- ...
RAMP3
2004). "Intermedin is a calcitonin/calcitonin gene-related peptide family peptide acting through the calcitonin receptor-like ... CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin gene-related peptide (CGRP) receptor or ... 2008). "Identification of N-terminal receptor activity-modifying protein residues important for calcitonin gene-related peptide ... 2004). "Characterization of the human calcitonin gene-related peptide receptor subtypes associated with receptor activity- ...
RAMP2
CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin gene-related peptide (CGRP) receptor or ... 2008). "Identification of N-terminal receptor activity-modifying protein residues important for calcitonin gene-related peptide ... 2004). "Characterization of the human calcitonin gene-related peptide receptor subtypes associated with receptor activity- ... of the cytoplasmic tails of the human receptor activity-modifying protein components of calcitonin gene-related peptide and ...
Circumventricular organs
... peptide histidine isoleucine, calcitonin gene-related peptide, substance P and somatostatin. Gross PM, Weindl A (1987). " ... Peptides. 31 (4): 757-76. doi:10.1016/j.peptides.2010.01.003. PMID 20093161. Morita S.; Miyata S. (2012). "Different vascular ... Other peptides aside from melatonin have been detected in the pineal. They are most likely associated with a type of ... Related to its secretory function, the SCO is partially composed of ependymal cells. These ependymocytes are characterized by ...
Pulp necrosis
They can interact with neuropeptides (substance P) and calcitonin gene-related peptide (CGRP) during the inflammatory response ...
RAMP1
"Functional calcitonin gene-related peptide receptors are formed by the asymmetric assembly of a calcitonin receptor-like ... CALCRL, a receptor with seven transmembrane domains, can function as either a calcitonin gene-related peptide (CGRP) receptor ... 2008). "Identification of N-terminal receptor activity-modifying protein residues important for calcitonin gene-related peptide ... 2004). "Characterization of the human calcitonin gene-related peptide receptor subtypes associated with receptor activity- ...
Parabrachial nuclei
"Calcitonin gene-related peptide immunoreactivity in the visceral sensory cortex, thalamus, and related pathways in the rat". ... of neurons in the external lateral parabrachial subnucleus that contain the neurotransmitter calcitonin gene-related peptide ( ... The parabrachial nucleus relays satiety and pain-related signals to higher brain regions; when inhibited, this can produce " ... Peptides. 8 (2): 267-283. doi:10.1016/0196-9781(87)90102-1. ISSN 0196-9781. PMID 2884646. Kaur, Satvinder; Pedersen, Nigel P.; ...
Alternative splicing
... calcitonin gene related peptide). Examples of alternative splicing in immunoglobin gene transcripts in mammals were also ... The gene encoding the thyroid hormone calcitonin was found to be alternatively spliced in mammalian cells. The primary ... Rosenfeld MG, Amara SG, Roos BA, Ong ES, Evans RM (March 1981). "Altered expression of the calcitonin gene associated with RNA ... Rosenfeld MG, Lin CR, Amara SG, Stolarsky L, Roos BA, Ong ES, Evans RM (March 1982). "Calcitonin mRNA polymorphism: peptide ...
Hair cell
... terminal bouton is filled with vesicles containing acetylcholine and a neuropeptide called calcitonin gene-related peptide. The ... Not only do hair cells in a culture dish regenerate when the Rb1 gene is deleted, but mice bred to be missing the gene grow ... The Rb1 gene encodes the retinoblastoma protein, which is a tumor suppressor. Rb stops cells from dividing by encouraging their ... Henderson M (2005-01-15). "Gene that may no longer turn a deaf ear to old age". Times Online. Sage, Cyrille; Huang, Mingqian; ...
Systematic evolution of ligands by exponential enrichment
"Short bioactive Spiegelmers to migraine-associated calcitonin gene-related peptide rapidly identified by a novel approach: ... Off-target binding to related molecules could have significant clinical effects. SELEX has been used to develop a number of ... Clinical uses of the technique are suggested by aptamers that bind tumor markers, GFP-related fluorophores, and a VEGF-binding ... Vavvas D, D'Amico DJ (September 2006). "Pegaptanib (Macugen): treating neovascular age-related macular degeneration and current ...
Jean-Pierre Changeux
Fontaine B., Klarsfeld A., Hokfelt T., Changeux J.-P. (1986). Calcitonin gene-related peptide, a peptide present in spinal cord ... and a stimulation of gene transcription at the synapse by the calcitonin gene-related peptide (CGRP) activating PKA and the ... Laufer R., and Changeux J.-P. (1987). Calcitonin gene-related peptide elevates cyclic AMP levels in chick skeletal muscle : ... Fontaine B., Klarsfeld A., Changeux J.-P. (1987). Calcitonin-gene related peptide and muscle activity regulate acetylcholine ...
Capsinolol
It is the first beta blocker with an associated calcitonin gene-related peptide releasing activity in the heart.[1] ... the first beta-adrenoceptor blocker with an associated calcitonin gene-related peptide releasing activity in the heart". Br J ... This drug article relating to the cardiovascular system is a stub. You can help Wikipedia by expanding it.. *v ...
Glucagon receptor
"Receptor activity modifying protein-directed G protein signaling specificity for the calcitonin gene-related peptide family of ... "Tissue-specific and glucose-dependent expression of receptor genes for glucagon and glucagon-like peptide-1 (GLP-1)". Hormone ... Gene. 393 (1-2): 127-36. doi:10.1016/j.gene.2007.01.023. PMID 17374560. v t e. ... Shiota D, Kasamatsu T, Dib SA, Chacra AR, Moisés RS (May 2002). "Role of the Gly40Ser mutation in the glucagon receptor gene in ...
FZD5
This transmembrane receptor-related article is a stub. You can help Wikipedia by expanding it.. *v ... Gene ontology. Molecular function. • amyloid-beta binding. • signal transducer activity. • Wnt-protein binding. • protein ... Frizzled-5 is a protein that in humans is encoded by the FZD5 gene.[5][6][7] ... 2000). "LDL-receptor-related proteins in Wnt signal transduction". Nature. 407 (6803): 530-5. doi:10.1038/35035117. PMID ...
Brain-derived neurotrophic factor
Genes on human chromosome 11. *Obsessive-compulsive disorder. *Neurotrophic factors. *Peptide hormones ... BDNF is a critical mediator of vulnerability to stress, memory of fear/trauma, and stress-related disorders such as post- ... Kaplan AS, Levitan RD, Yilmaz Z, Davis C, Tharmalingam S, Kennedy JL (January 2008). "A DRD4/BDNF gene-gene interaction ... Brain-derived neurotrophic factor (BDNF), or abrineurin,[5] is a protein[6] that, in humans, is encoded by the BDNF gene.[7][8] ...
AKTIP - ويكيبيديا
"A cDNA encoding the calcitonin gene-related peptide type 1 receptor". J Biol Chem. 271 (19): 11325-9. doi:10.1074/jbc.271.19. ... Lesche R, Peetz A, van der Hoeven F, Rüther U (1998). "Ft1, a novel gene related to ubiquitin-conjugating enzymes, is deleted ... "Entrez Gene: AKTIP AKT interacting protein". مؤرشف من الأصل في 05 ديسمبر 2010.. الوسيط ,CitationClass=. تم تجاهله (مساعدة). ... Fluhmann B, Muff R, Hunziker W, Fischer JA, Born W (Feb 1995). "A human orphan calcitonin receptor-like structure". Biochem ...
CD30
"Entrez Gene: TNFRSF8 tumor necrosis factor receptor superfamily, member 8".. *^ Teng LH, Lu DH, Xu QZ, Fu YJ, Yang H, He ZL ( ... "Genes & Development. 11 (21): 2810-21. doi:10.1101/gad.11.21.2810. PMC 316646. PMID 9353251.. ... Gene ontology. Molecular function. • transmembrane signaling receptor activity. • tumor necrosis factor-activated receptor ... Fonatsch C, Latza U, Dürkop H, Rieder H, Stein H (Nov 1992). "Assignment of the human CD30 (Ki-1) gene to 1p36". Genomics. 14 ( ...
Bradykinin
Calcitonin gene-related peptide. *Carnosine. *Cocaine- and amphetamine-regulated transcript. *Delta sleep-inducing peptide ... Bradykinin is a 9-amino acid peptide chain. The amino acid sequence of bradykinin is: Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg ( ... It is a peptide that causes blood vessels to dilate (enlarge), and therefore causes blood pressure to fall. A class of drugs ... The discovery was part of a continuing study on circulatory shock and proteolytic enzymes related to the toxicology of snake ...
GPR120
Gene ontology. Molecular function. • peptide binding. • signal transducer activity. • taste receptor activity. • fatty acid ... This transmembrane receptor-related article is a stub. You can help Wikipedia by expanding it.. *v ... "Entrez Gene: GPR120 G protein-coupled receptor 120".. *^ Oh DY, Talukdar S, Bae EJ, Imamura T, Morinaga H, Fan W, Li P, Lu WJ, ... G-protein coupled receptor 120 is a protein that in humans is encoded by the GPR120 gene.[5][6] ...
Puromycin
Deletion of the gene encoding the multidrug efflux pump Pdr5 sensitizes cells to puromycin.[citation needed] ... The puromycin can then form a covalent link to the growing peptide chain allowing the mRNA to be physically linked to its ... Resistance to puromycin is conferred by the pac gene encoding a puromycin N-acetyl-transferase (PAC) that was found in a ... Puromycin resistance in yeast can also be conferred through expression of the puromycin N-acetyl-transferase (pac) gene.[8] ...
Insulin-like growth factor 2
Genes on human chromosome 11. *Peptide hormones. *Growth factors. *Hormones of the somatotropic axis ... As IGF2 promotes development of fetal pancreatic beta cells, it is believed to be related to some forms of diabetes mellitus. ... Gene structure[edit]. In humans, the IGF2 gene is located on chromosome 11p15.5, a region which contains numerous imprinted ... Gene ontology. Molecular function. • insulin receptor binding. • hormone activity. • GO:0001948 protein binding. • growth ...
Brain-derived neurotrophic factor
Genes on human chromosome 11. *Obsessive-compulsive disorder. *Neurotrophic factors. *Peptide hormones ... In addition to mediating transient effects on NMDAR activation to promote memory-related molecular changes, BDNF should also ... Kaplan AS, Levitan RD, Yilmaz Z, Davis C, Tharmalingam S, Kennedy JL (January 2008). "A DRD4/BDNF gene-gene interaction ... Brain-derived neurotrophic factor, also known as BDNF, is a protein[5] that, in humans, is encoded by the BDNF gene.[6][7] BDNF ...
GPR34
This transmembrane receptor-related article is a stub. You can help Wikipedia by expanding it.. *v ... Probable G-protein coupled receptor 34 is a protein that in humans is encoded by the GPR34 gene.[5][6][7] ... Gene ontology. Molecular function. • G-protein coupled purinergic nucleotide receptor activity. • G-protein coupled receptor ... "Physical mapping and exclusion of GPR34 as the causative gene for congenital stationary night blindness type 1". Human Genetics ...
Peptide
Several terms related to peptides have no strict length definitions, and there is often overlap in their usage. ... gene-encoded antibacterial peptides from enterobacteria". Natural Product Reports. 24 (4): 708-34. doi:10.1039/b516237h. PMID ... Calcitonin peptidesEdit. *Calcitonin. *Amylin. *AGG01. Other peptidesEdit. *B-type Natriuretic Peptide (BNP) - produced in ... fungal peptides, invertebrate peptides, amphibian/skin peptides, venom peptides, cancer/anticancer peptides, vaccine peptides ...
Adrenocorticotropic hormone
Calcitonin gene-related peptide. *Carnosine. *Cocaine- and amphetamine-regulated transcript. *Delta sleep-inducing peptide ... Glucocorticoids may also inhibit the rates of POMC gene transcription and peptide synthesis. The latter is an example of a slow ... A family of related receptors mediates the actions of these hormones, the MCR, or melanocortin receptor family. These are ... ACTH is also related to the circadian rhythm in many organisms.[2] ...
Homeostasis
Gene regulation[edit]. Main article: Regulation of gene expression. At the cellular level, homeostasis is carried out by ... Other normal temperature variations include those related to the menstrual cycle.[15][16] The temperature regulator's set point ... This causes heart muscle cells to secrete the hormone atrial natriuretic peptide (ANP) into the blood. This acts on the kidneys ... The two homeostatic mechanisms working through PTH on the one hand, and calcitonin on the other can very rapidly correct any ...
Adenosine receptor
"Entrez Gene: ADORA2A adenosine A2A receptor".. *^ a b Jacobson KA, Gao ZG (2006). "Adenosine receptors as therapeutic targets" ... age related changes as well as injury repair. ... Calcitonin. *CALCRL. *CD97. *Corticotropin-releasing hormone (1 ... rather than chondrocyte via the Runx2 gene expression.[24] Potential therapeutic application in aiding bone degenerative ... each is encoded by a different gene. ... Gene. Mechanism [15]. Effects. Agonists. Antagonists A1 ADORA1 ...
Telcagepant
... (INN) (code name MK-0974) is a calcitonin gene-related peptide receptor antagonist which was an investigational ... a new oral antagonist of calcitonin gene-related peptide receptor, compared with zolmitriptan for acute migraine: a randomised ...
Galanin receptor 1
This transmembrane receptor-related article is a stub. You can help Wikipedia by expanding it. *v ... "Alcoholism is associated with GALR3 but not two other galanin receptor genes". Genes, Brain, and Behavior. 6 (5): 473-81. PMID ... peptide hormone binding. • galanin receptor activity. • protein binding. Cellular component. • integral component of membrane. ... Gene ontology. Molecular function. • G-protein coupled receptor activity. • neuropeptide binding. • signal transducer activity ...
FAK
... family member HEF1 downstream of the G protein-coupled calcitonin receptor. Calcitonin induces the association of HEF1, ... "Focal adhesion kinase and paxillin bind to peptides mimicking beta integrin cytoplasmic domains". The Journal of Cell Biology ... "PTK2 - Focal adhesion kinase 1 - Gallus gallus (Chicken) - PTK2 gene & protein" (英語). www.uniprot.org. 2021年9月5日閲覧。. ... "Interaction of Hic-5, A senescence-related protein, with focal adhesion kinase". The Journal of Biological Chemistry 273 (41): ...
کلسیتونین - ویکیپدیا، دانشنامهٔ آزاد
Gene Ontology. Molecular function. • receptor binding. • hormone activity. • protein binding. • calcitonin receptor binding. • ... Calcitonin-related polypeptide alpha. NMR solution structure of salmon calcitonin in SDS micelles.[۱] ... "Structural determinants of salmon calcitonin bioactivity: the role of the Leu-based amphipathic alpha-helix". J. Biol. Chem. ... OMIM: 114130 MGI: 2151253 HomoloGene: 105263 ChEMBL: 5293 GeneCards: CALCA Gene. ...
TAS2R38
Taste receptor 2 member 38 is a protein that in humans is encoded by the TAS2R38 gene. TAS2R38 is a bitter taste receptor; ... was shown to be directly related to TAS2R38 genotype.[6][7][10][11][12] There are three common polymorphisms in the TAS2R38 ... Gene ontology. Molecular function. • G-protein coupled receptor activity. • signal transducer activity. • bitter taste receptor ... A gene altering the density of fungiform papillae may provide this second factor.[5] ...
Neuromedin N
Calcitonin gene-related peptide. *Carnosine. *Cocaine- and amphetamine-regulated transcript. *Delta sleep-inducing peptide ... Peptides. 27 (10): 2508-14. doi:10.1016/j.peptides.2006.03.038. PMID 16904237.. ... "Production of recombinant large proneurotensin/neuromedin N-derived peptides and characterization of their binding and ...
Cysteinyl leukotriene receptor 2
Gene ontology. Molecular function. • protein binding. • G-protein coupled peptide receptor activity. • signal transducer ... Perhaps related to this difference in CysLT sensitivities, cells co-expressing CysLTR2 and CysLTR1 may exhibit lower ... Gene[edit]. The human CysLTR2 gene maps to the long arm of chromosome 13 at position 13q14, a chromosomal region that has long ... The gene consists of four exons with all introns located in the genes' 5' UTR region and the entire coding region located in ...
Epidermal growth factor
... and increases in the expression of certain genes including the gene for EGFR - that ultimately lead to DNA synthesis and cell ... Wikimedia Commons has media related to Epidermal growth factor, EGF.. *Shaanxi Zhongbang Pharma-Tech Co., Ltd.-Supply of ... EGF was originally described as a secreted peptide found in the submaxillary glands of mice and in human urine. EGF has since ... Gene ontology. Molecular function. • calcium ion binding. • transmembrane receptor protein tyrosine kinase activator activity. ...
Kalsitonin bahasa Indonesia, ensiklopedia bebas
... yang disebut calcitonin gene-related peptide (CGRP), jenis beta.[6] Berikut ini adalah urutan asam amino dari salmon dan ... "Calcitonin and calcitonin receptors". Regional Center for Hereditary Endocrine Tumors Department of Internal Medicine, ... "calcitonin domain annotation". SMART (a Simple Modular Architecture Research Tool). embl-heidelberg.de. Diakses tanggal 2009-02 ... Carney SL (1997). "Calcitonin and human renal calcium and electrolyte transport". Miner Electrolyte Metab. 23 (1): 43-7. PMID ...
Oxytocin
Calcitonin gene-related peptide. *Carnosine. *Cocaine- and amphetamine-regulated transcript. *Delta sleep-inducing peptide ... The two genes are believed to result from a gene duplication event; the ancestral gene is estimated to be about 500 million ... The oxytocin peptide is synthesized as an inactive precursor protein from the OXT gene.[18][19][20] This precursor protein also ... Sausville E, Carney D, Battey J (August 1985). "The human vasopressin gene is linked to the oxytocin gene and is selectively ...
Erekcia (človek) - Wikipédia
Vedľajšie: prostacyklín, VIP, CGRF (=Calcitonin Gene-Related Peptide), prostaglandíny - predovšetkým PGE1.. *Mediátory ...
GPR26
This transmembrane receptor-related article is a stub. You can help Wikipedia by expanding it.. *v ... Probable G-protein coupled receptor 26 is a protein that in humans is encoded by the GPR26 gene.[5] ... "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 ( ...
GPER
Choleris E (11 April 2013). Oxytocin, Vasopressin and Related Peptides in the Regulation of Behavior. Cambridge University ... cellular response to peptide hormone stimulus. • positive regulation of gene expression. • cellular response to ... "Entrez Gene: GPR30 G protein-coupled receptor 30".. *^ Hazell GG, Yao ST, Roper JA, Prossnitz ER, O'Carroll AM, Lolait SJ ( ... Gene ontology. Molecular function. • estrogen receptor activity. • steroid hormone binding. • chromatin binding. • protein ...
Tachykinin receptor 3
See also: Receptor/signaling modulators • Signaling peptide/protein receptor modulators. This transmembrane receptor-related ... This gene belongs to a family of genes that function as receptors for tachykinins. Receptor affinities are specified by ... Tachykinin receptor 3, also known as TACR3, is a protein which in humans is encoded by the TACR3 gene.[5][6] ... "Entrez Gene: TACR3 tachykinin receptor 3".. *^ Quartara L, Altamura M (Aug 2006). "Tachykinin receptors antagonists: from ...
calcitonin gene-related peptide | Modern medicine
Calcitonin gene-related peptide regulates muscle acetylcholine receptor synthesis. - PubMed - NCBI
Calcitonin gene-related peptide - Wikipedia
Calcitonin gene-related peptide (CGRP) is a member of the calcitonin family of peptides, which in humans exists in two forms: α ... Regulation of the calcitonin gene-related peptide (CGRP) gene is in part controlled by the expression of the mitogen-activated ... The mammalian calcitonin gene-related peptides, adrenomedullin, amylin, and calcitonin receptors". Pharmacological Reviews. 54 ... Prophylactic therapy with calcitonin gene‐related peptides (CGRPs) may have unknown fertility consequences for women of child ...
The CGRP Family: Calcitonin Gene-Related Peptide (CGRP), Amylin and Ad
... the Third International Meeting on CGRP and relate ... The CGRP Family: Calcitonin Gene-Related Peptide (CGRP), Amylin ... Calcitonin Gene-Related Peptide in Gastrointestinal Homeostasis 13. CGRP and Neurogenic Vasodilatation: Role of Nerve Growth ... This book is based on presentations given at CGRP 98, the Third International Meeting on CGRP and related peptides held in the ... Section 1: Pharmacology and Molecular Biology of CGRP Receptors 1. Multiple Receptors for CGRP and Related Peptides 2. CGRP ...
Calcitonin gene-related peptide receptor antagonist - Wikipedia
Calcitonin gene-related peptide (CGRP) receptor antagonists are a class of drug candidates that act as antagonists of the ... Mitsikostas, DD; Reuter, U (2017). "Calcitonin gene-related peptide monoclonal antibodies for migraine prevention: comparisons ... an Oral Calcitonin Gene Related Peptide Receptor Antagonist". British Journal of Clinical Pharmacology. 79 (5): 831-7. doi: ... calcitonin gene-related peptide receptor (CGRPR). CGRPR antagonists are under investigation as potential antimigraine agents ...
What is the role of calcitonin gene-related peptide (CGRP) in the pathogenesis of anaphylaxis?
Calcitonin gene-related peptide (CGRP), a sensory neurotransmitter that is widely distributed in cardiovascular tissues, may ... What is the role of calcitonin gene-related peptide (CGRP) in the pathogenesis of anaphylaxis?. Updated: May 16, 2018 ... Calcitonin gene-related peptide (CGRP), a sensory neurotransmitter that is widely distributed in cardiovascular tissues, may ... encoded search term (What is the role of calcitonin gene-related peptide (CGRP) in the pathogenesis of anaphylaxis?) and What ...
What is the role of calcitonin gene-related peptide (CGRP) in the pathogenesis of anaphylaxis?
Calcitonin gene-related peptide (CGRP), a sensory neurotransmitter that is widely distributed in cardiovascular tissues, may ... What is the role of calcitonin gene-related peptide (CGRP) in the pathogenesis of anaphylaxis?. Updated: May 16, 2018 ... Calcitonin gene-related peptide (CGRP), a sensory neurotransmitter that is widely distributed in cardiovascular tissues, may ... Anaphylaxis syndromes related to a new mammalian cross-reactive carbohydrate determinant. J Allergy Clin Immunol. 2009 Oct. 124 ...
Calcitonin Gene-related Peptide Levels in Chronic Migraine - Full Text View - ClinicalTrials.gov
Calcitonin. Salmon calcitonin. Calcitonin Gene-Related Peptide. Botulinum Toxins, Type A. abobotulinumtoxinA. Katacalcin. ... Calcitonin Gene-related Peptide Levels in Chronic Migraine. The safety and scientific validity of this study is the ... MedlinePlus related topics: Botox Genes and Gene Therapy Headache Migraine Drug Information available for: Calcitonin ... Elevated saliva calcitonin gene-related peptide levels during acute migraine predict therapeutic response to rizatriptan. ...
Amylin, calcitonin gene-related peptide, calcitonin, and adrenomedullin: a peptide superfamily. - PubMed - NCBI
The calcitonin gene peptide superfamily consists of calcitonin (CT), calcitonin gene-related peptide (CGRP), and amylin. CT and ... Amylin, calcitonin gene-related peptide, calcitonin, and adrenomedullin: a peptide superfamily.. Wimalawansa SJ1. ... Calcitonin Gene-Related Peptide/chemistry. *Calcitonin Gene-Related Peptide/genetics. *Calcitonin Gene-Related Peptide/ ... and amylin are related to the insulin gene superfamily of peptides, which may all have diverged from a common ancestral gene ...
Calcb - Calcitonin gene-related peptide 2 - Mus musculus (Mouse) - Calcb gene & protein
Calcitonin gene-related peptide 2. Calcitonin gene-related peptide 2 (Beta-type CGRP) (Calcitonin gene-related peptide II, CGRP ... IPR021117 Calcitonin-like. IPR021116 Calcitonin/adrenomedullin. IPR018360 Calcitonin_CS. IPR015476 Calcitonin_gene-rel_peptide ... IPR021117 Calcitonin-like. IPR021116 Calcitonin/adrenomedullin. IPR018360 Calcitonin_CS. IPR015476 Calcitonin_gene-rel_peptide ... Calcitonin gene-related peptide 2Imported. ,p>Information which has been imported from another database using automatic ...
Distribution of substance P and the calcitonin gene-related peptide in the human tensor tympani muscle | SpringerLink
... and calcitonin gene-related peptide-immunoreactive nerve fiber (CGRP-IR NF) are important mediators of neurogenic inflammation ... Corcoran BM, Mayhew IG, Hahn CN, Prince DR (2000) Expression of vasoactive intestinal peptide, calcitonin gene-related peptide ... The distribution of nerve fibres immunoreactive for vasoactive intestinal peptide, calcitonin gene-related peptide, substance P ... The distribution of Calcitonin gene-related peptide-immunoreactive nerve fibers (CGRP-IR NFs) in the inner surface region of ...
Enhanced Vasodilator Responses to CGRP (Calcitonin Gene-Related Peptide) in Subcutaneous Arteries in Human Hypertension
α-Calcitonin Gene Related Peptide, α-CGRP, rat
Cardiovascular Related Peptides , α-Calcitonin Gene Related Peptide, α-CGRP, rat; α-CGRP is preferentially expressed in sensory ... Peptides , Cardiovascular Related Peptides ,, α-Calcitonin Gene Related Peptide, α-CGRP, rat. ... α - Calcitonin Gene Related Peptide, α - CGRP, rat. SCNTATCVTHRLAGLLSRSGGVVKDNFVPTNVGSEAF - NH2 (Disulfide bridge: 2 - 7). ...
'calcitonin gene related peptide' Protocols and Video...
... calcitonin gene related peptide include Primer-Free Aptamer Selection Using A Random DNA Library, Assessment of Vascular ... Calcitonin Gene-Related Peptide: Calcitonin gene-related peptide. A 37-amino acid peptide derived from the calcitonin gene. It ... The peptide produces multiple biological effects and has both circulatory and neurotransmitter modes of action. In particular, ... occurs as a result of alternative processing of mRNA from the calcitonin gene. The neuropeptide is widely distributed in neural ...
Frontiers | Protective Role of α-Calcitonin Gene-Related Peptide in Cardiovascular Diseases | Physiology
"α-calcitonin gene related peptide (α-CGRP) is a regulatory neuropeptide of 37-amino acids. It is widely distributed in the ... "α-calcitonin gene related peptide (α-CGRP) is a regulatory neuropeptide of 37-amino acids. It is widely distributed in the ... α-Calcitonin gene-related peptide (α-CGRP) is a regulatory neuropeptide that belongs to the calcitonin/CGRP peptide family that ... 2000). Increased blood pressure in alpha-calcitonin gene-related peptide/calcitonin gene knockout mice. Hypertension 35, 470- ...
CALCB - Calcitonin gene-related peptide 2 precursor - Homo sapiens (Human) - CALCB gene & protein
... help/peptide target=_top>More...,/a>,/p>PeptideiPRO_0000004087. 82 - 118. Calcitonin gene-related peptide 2Add BLAST. 37. ... IPR021117 Calcitonin-like. IPR021116 Calcitonin/adrenomedullin. IPR018360 Calcitonin_CS. IPR015476 Calcitonin_gene-rel_peptide ... IPR021117 Calcitonin-like. IPR021116 Calcitonin/adrenomedullin. IPR018360 Calcitonin_CS. IPR015476 Calcitonin_gene-rel_peptide ... sp,P10092,CALCB_HUMAN Calcitonin gene-related peptide 2 OS=Homo sapiens OX=9606 GN=CALCB PE=1 SV=1 ...
Dural Calcitonin Gene-Related Peptide Produces Female-Specific Responses in Rodent Migraine Models | Journal of Neuroscience
Dural Calcitonin Gene-Related Peptide Produces Female-Specific Responses in Rodent Migraine Models. Amanda Avona, Carolina ... Calcitonin gene-related peptide (CGRP) has been implicated in the pathology of migraine for several decades. CGRP is elevated ... SIGNIFICANCE STATEMENT Calcitonin gene-related peptide (CGRP) has long been implicated in the pathophysiology of migraine, and ... 2017) The role of calcitonin gene-related peptide in peripheral and central pain mechanisms including migraine. Pain 158:543- ...
Calcitonin Gene-Related Peptide (Cgrp), Adrenomedullin (Am), Amylin, And Calcitonin (Ct) Receptors And Overlapping Biological...
Induction of Insulin Resistance In Vivo by Amylin and Calcitonin Gene-Related Peptide | Diabetes
During hyperinsulinemic glucose-clamp studies, intravenous infusion of calcitonin gene-related peptide (CGRP) in rats ... Induction of Insulin Resistance In Vivo by Amylin and Calcitonin Gene-Related Peptide. ... Induction of Insulin Resistance In Vivo by Amylin and Calcitonin Gene-Related Peptide ... Induction of Insulin Resistance In Vivo by Amylin and Calcitonin Gene-Related Peptide ...
Calcitonin Gene-Related Peptide
Summary Report | CureHunter
Calcitonin gene-related peptide. A 37-amino acid peptide derived from the calcitonin gene. It occurs as a result of alternative ... The peptide produces multiple biological effects and has both circulatory and neurotransmitter modes of action. In particular, ... processing of mRNA from the calcitonin gene. The neuropeptide is widely distributed in neural tissue of the brain, gut, ... Calcitonin Gene Related Peptide; Calcitonin Gene Related Peptide I; Calcitonin Gene Related Peptide II; Gene-Related Peptide, ...
Calcitonin gene-related peptide (CGRP) and cluster headache
... Belin, Andrea Carmine ; Ran, Caroline and Edvinsson, Lars LU (2020 ... Calcitonin gene-related peptide (CGRP) is a potent vasodilator, originating in trigeminal neurons and has a central role in CH ... Calcitonin gene-related peptide (CGRP) is a potent vasodilator, originating in trigeminal neurons and has a central role in CH ... Calcitonin gene-related peptide (CGRP) is a potent vasodilator, originating in trigeminal neurons and has a central role in CH ...
Calcitonin Gene Related Peptide - Pipeline Review, H2 2020
H2 2020 Calcitonin Gene Related Peptide - Pipeline Review, H2 2020 Summary According to the recently published report ... Calcitonin Gene - Market research report and industry analysis - 13709614 ... Calcitonin Gene Related Peptide (CGRP) - Calcitonin gene related peptide (CGRP) is a member of the calcitonin family of ... Calcitonin Gene Related Peptide (CGRP) - Overview. Calcitonin Gene Related Peptide (CGRP) - Therapeutics Development. Products ...
Calcitonin gene-related peptide does not excite or sensitize meningeal nociceptors: Implications for the pathophysiology of...
Smriti Iyengar, Michael H. Ossipov, Kirk W. Johnson, The role of calcitonin gene-related peptide in peripheral and central pain ... Calcitonin gene-related peptide does not excite or sensitize meningeal nociceptors: Implications for the pathophysiology of ... A growing body of evidence points to a critical role of calcitonin gene-related peptide (CGRP) in the pathophysiology of ... Håkan Ashina, Lawrence Newman, Sait Ashina, Calcitonin gene-related peptide antagonism and cluster headache: an emerging new ...
Calcitonin Gene-Related Peptide (CGRP), a New Endocrine Factor Involved in the Complex Multi-hormonal Control of the Gill...
... calcitonin (CT) in the thyroid C cells and calcitonin gene-related peptide... ... alternative tissue-specific processing of initial mRNA from the calcitonin gene generates two distinct peptides: ... Calcitonin gene-related peptide in the regulation of cardiac function. Calcitonin gene-related peptide. The first decade of a ... Wimalawansa SJ (1997) Amylin, calcitonin gene-related peptide, calcitonin, and adrenomedullin: a peptide superfamily. Crit Rev ...
Pregnancy and Steroid Hormones Enhance the Systemic and Regional Hemodynamic Effects of Calcitonin Gene-Related Peptide in Rats1
Calcitonin gene-related peptide (CGRP) is a potent vasodilator neuropeptide known to be involved in the regulation of vascular ... Pregnancy and Steroid Hormones Enhance the Systemic and Regional Hemodynamic Effects of Calcitonin Gene-Related Peptide in Rats ... "Pregnancy and Steroid Hormones Enhance the Systemic and Regional Hemodynamic Effects of Calcitonin Gene-Related Peptide in Rats ... "Pregnancy and Steroid Hormones Enhance the Systemic and Regional Hemodynamic Effects of Calcitonin Gene-Related Peptide in Rats ...
Role of calcitonin gene-related peptide and brain natriuretic peptide | JRLCR
Using calcitonin gene-related peptide (CGRP) and brain natriuretic peptide (BNP) as examples, this review addresses the ... For either peptide, the key target appears to be the ATP-gated P2X3 receptor that, widely expressed by trigeminal sensory ... The fine balance between the activities of these peptides is suggested to ultimately determine whether nociception is perceived ... to sequester this peptide or to directly inhibit its receptor) is currently considered a novel approach for migraine ...
Frontiers | New Trends in Migraine Pharmacology: Targeting Calcitonin Gene-Related Peptide (CGRP) With Monoclonal Antibodies |...
The demonstrated pivotal role of calcitonin gene-related peptide (CGRP) has fostered the development of CGRP antagonists, ... The demonstrated pivotal role of calcitonin gene-related peptide (CGRP) has fostered the development of CGRP antagonists, ... Pathophysiology of Migraine and Calcitonin Gene-Related Peptide (CGRP). The exact cause of migraine attacks is not well known ... Russell, F. A., King, R., Smillie, S. J., Kodji, X., and Brain, S. D. (2014). Calcitonin gene-related peptide: physiology and ...
Abstract 605: Calcitonin Gene Related Peptide (cgrp) And Its Role In Cardiovascular And Autonomic Regulation | Hypertension
Abstract 605: Calcitonin Gene Related Peptide (cgrp) And Its Role In Cardiovascular And Autonomic Regulation. Tu Mai, Andre M ... Calcitonin gene related peptide (CGRP) is the most potent microvascular vasodilator known. It exerts effects centrally as well ... Abstract 605: Calcitonin Gene Related Peptide (cgrp) And Its Role In Cardiovascular And Autonomic Regulation ... Abstract 605: Calcitonin Gene Related Peptide (cgrp) And Its Role In Cardiovascular And Autonomic Regulation ...
Calcitonin gene-related peptide - Biology-Online Dictionary | Biology-Online Dictionary
Calcitonin gene-related peptide (Science: protein) a second product transcribed from the calcitonin gene. Calcitonin gene ... Retrieved from "https://www.biology-online.org/dictionary/index.php?title=Calcitonin_gene-related_peptide&oldid=64605" ... It occurs as a result of alternative processing of mrna from the calcitonin gene. ... related peptide is found in a number of tissues including nervous Tissue. It is a vasodilator that may participate in the ...
Calcitonin Gene-Related Peptide in the Bed Nucleus of the Stria Terminalis Produces an Anxiety-Like Pattern of Behavior and...
Calcitonin gene-related peptide (CGRP) is one such peptide. CGRP innervation of the BNST arises primarily from parabrachial ... 1996) The effects of central injections of calcitonin gene-related peptide on fear-related behavior. Neurobiol Learn Mem 66:241 ... 2005) Calcitonin gene-related peptide-containing pathways in the rat forebrain. J Comp Neurol 489:92-119. ... Calcitonin Gene-Related Peptide in the Bed Nucleus of the Stria Terminalis Produces an Anxiety-Like Pattern of Behavior and ...
CGRPAdrenomedullinReceptorsNeuropeptideAlpha-Calcitonin gene-reVasodilatorNeuronsImmunoreactivityHUMAN CalcitoninPolypeptideSensoryMonoclonalEndogenousAmino acidsPharmacologyAntagonistMRNASubstanceAntibodiesSynthesisPathwaysAntagonismGastricSubarachnoid hemorrhageCGRPsIschemiaCluster headacheResponsesReceptor calledThyroidAffinityExpressionNeurotransmitterHypertensionHomologousAntibody1991Protein-coupled receptorCoronary arteryInhibits
CGRP133
- Calcitonin gene-related peptide (CGRP) is a member of the calcitonin family of peptides, which in humans exists in two forms: α-CGRP and β-CGRP, also known as CGRP I and CGRP II. (wikipedia.org)
- CGRP I or α-CGRP is a 37-amino acid neuropeptide and is formed from the alternative splicing of the calcitonin/CGRP gene located on chromosome 11. (wikipedia.org)
- In humans, β-CGRP differs from the α-CGRP by three amino acids and is encoded in a separate gene within the same vicinity. (wikipedia.org)
- The CGRP family includes calcitonin (CT), adrenomedullin (AM), and amylin (AMY). (wikipedia.org)
- CGRP mediates its effects through a heteromeric receptor composed of a G protein-coupled receptor called calcitonin receptor-like receptor (CALCRL) and a receptor activity-modifying protein (RAMP1). (wikipedia.org)
- Regulation of the calcitonin gene-related peptide (CGRP) gene is in part controlled by the expression of the mitogen-activated protein kinases (MAPK) signaling pathway, cytokines such as TNFα and iNOS. (wikipedia.org)
- The CGRP receptor has three subunits: receptor activity-modifying protein 1 (RAMP1), calcitonin-like receptor (CLR) and receptor component protein (RCP). (wikipedia.org)
- The complex central receptor is the G protein-coupled receptor calcitonin receptor-like receptor (CALCRL) which is necessary for CGRP and adrenomedullin (AM receptors). (wikipedia.org)
- A molecule immunologically related to calcitonin gene-related peptide (CGRP-I) has been found in motoneurones in a variety of mammals including man. (nih.gov)
- Calcitonin gene-related peptide (CGRP) receptor antagonists are a class of drug candidates that act as antagonists of the calcitonin gene-related peptide receptor (CGRPR). (wikipedia.org)
- This book is based on presentations given at CGRP '98, the Third International Meeting on CGRP and related peptides held in the UK in May 1998. (routledge.com)
- An exciting story is emerging of how a single molecule, calcitonin receptor-like receptor (CRLR), can mediate the response to both CGRP and adrenomedullin depending on the presence of different members of a family of accessory proteins, the Receptor Activity Modifying Proteins (RAMPs). (routledge.com)
- Multiple Receptors for CGRP and Related Peptides 2. (routledge.com)
- What is the role of calcitonin gene-related peptide (CGRP) in the pathogenesis of anaphylaxis? (medscape.com)
- Calcitonin gene-related peptide (CGRP), a sensory neurotransmitter that is widely distributed in cardiovascular tissues, may help to counteract coronary artery vasoconstriction during anaphylaxis. (medscape.com)
- Twenty patients will be enrolled in a 2-site, 7-month, double-blind study conducted to evaluate a reduction in headache days and attacks and calcitonin gene-related peptide (CGRP) levels in saliva following treatment with OnabotulinumtoxinA versus saline. (clinicaltrials.gov)
- The calcitonin gene peptide superfamily consists of calcitonin (CT), calcitonin gene-related peptide (CGRP), and amylin. (nih.gov)
- CT and CGRP derive from the CT/CGRP gene, which is encoded on chromosome 11. (nih.gov)
- Alternative splicing of the primary RNA transcript leads to the translation of CGRP and CT peptides in a tissue-specific manner. (nih.gov)
- CGRP (a 37-amino-acid neuropeptide) and its receptors are widely distributed in the body, and it is the most potent endogenous vasodilatory peptide discovered so far. (nih.gov)
- Amylin (a 37-amino-acid peptide) is generated from a gene located on chromosome 12 (thought to be an evolutionary duplication of chromosome 11) and shares 46% amino acid sequence homology with CGRP and 20% with human CT. (nih.gov)
- Adrenomedullin, a recently discovered 52-amino-acid vasoactive peptide from adrenal tissue, shares 24% homology with CGRP and is also a member of this superfamily of peptides. (nih.gov)
- Not only does adrenomedullin (13-52) show 24% amino acid homology with CGRP, it also has a biological activity profile similar to that of CGRP.CGRP, CT, and amylin are related to the insulin gene superfamily of peptides, which may all have diverged from a common ancestral gene during evolution. (nih.gov)
- When the crystallographic- and nuclear magnetic resonance-based molecular modeling of the three-dimensional structure of CGRP, CT, amylin, and adrenomedullin peptides and their receptors is available, it will lead to a greater understanding of the involvement of this family of peptides in pathophysiology. (nih.gov)
- I propose that CT, CGRP, adrenomedullin, and amylin belong to a family of G-protein-coupled receptors (an "insulin superfamily" of peptides) and therefore share some of the characteristics of insulin, such as growth factor-like effects, and possible interaction at insulin receptor sites as an antagonist. (nih.gov)
- Substance P-immunoreactive nerve fiber (SP-IR NF) and calcitonin gene-related peptide-immunoreactive nerve fiber (CGRP-IR NF) are important mediators of neurogenic inflammation and blood supply. (springer.com)
- α-Calcitonin gene-related peptide (α-CGRP) is a regulatory neuropeptide of 37 amino acids. (frontiersin.org)
- In thyroid C cells, the CALC-I gene product containing exon 4 forms calcitonin, whereas the CALC-I gene product containing exons 5 and 6 forms α-CGRP in sensory neurons ( Figure 1 ). (frontiersin.org)
- Peptide α-CGRP is a single polypeptide of 37 amino acids containing a disulfide bridge between positions 2 and 7 and a phenylalanine amide residue at the C-terminal. (frontiersin.org)
- Schematic diagram showing the synthesis of calcitonin and α-CGRP from a common gene CALC-I. Calcitonin gene CALC-I undergoes alternative splicing and forms protein calcitonin in thyroid C cells, and α-CGRP in the sensory neurons. (frontiersin.org)
- Using preclinical behavioral models of migraine, we show that application of calcitonin gene-related peptide (CGRP) to the rat dura mater produces cutaneous periorbital hypersensitivity. (jneurosci.org)
- SIGNIFICANCE STATEMENT Calcitonin gene-related peptide (CGRP) has long been implicated in the pathophysiology of migraine, and CGRP-based therapeutics are efficacious for the treatment of migraine in humans. (jneurosci.org)
- Muscle inflammation and hyperalgesia induced by adjuvant injection into skeletal muscle are associated with an increase in calcitonin gene-related peptide (CGRP) labeling in skeletal muscle and dorsal root ganglia (DRG). (cdc.gov)
- Amylin is a peptide isolated from amyloid deposits in pancreatic islets of type II (non-insulin-dependent) diabetic subjects, is present in normal β-cells, and bears a striking homology to CGRP. (diabetesjournals.org)
- Calcitonin gene-related peptide (CGRP) is a potent vasodilator, originating in trigeminal neurons and has a central role in CH pathophysiology. (lu.se)
- Calcitonin Gene Related Peptide (CGRP) pipeline Target constitutes close to 12 molecules. (marketresearch.com)
- Calcitonin Gene Related Peptide (CGRP) - Calcitonin gene related peptide (CGRP) is a member of the calcitonin family of peptides. (marketresearch.com)
- It also reviews key players involved in Calcitonin Gene Related Peptide (CGRP) targeted therapeutics development with respective active and dormant or discontinued projects. (marketresearch.com)
- A growing body of evidence points to a critical role of calcitonin gene-related peptide (CGRP) in the pathophysiology of migraine headache. (wiley.com)
- A current hypothesis suggests that peripheral CGRP and its related meningeal vasodilatation results in activation and sensitization, leading to the generation of migraine headache. (wiley.com)
- In mammals, alternative tissue-specific processing of initial mRNA from the calcitonin gene generates two distinct peptides: calcitonin (CT) in the thyroid C cells and calcitonin gene-related peptide (CGRP) in the peripheral and central nerves (Copp et al. (springer.com)
- Arlot-Bonnemains Y, Fouchereau-Peron M, Julienne A, Milhaud G, Moukhtar MS (1991) Binding sites of calcitonin gene related peptide (CGRP) to trout tissues. (springer.com)
- Brain SD (2004) Calcitonin gene-related peptide (CGRP) antagonists: blockers of neuronal transmission in migraine. (springer.com)
- Calcitonin gene-related peptide (CGRP) is a potent vasodilator neuropeptide known to be involved in the regulation of vascular resistance. (bioone.org)
- Using calcitonin gene-related peptide (CGRP) and brain natriuretic peptide (BNP) as examples, this review addresses the mechanisms through which neuropeptides might modulate nociceptor activity. (dovepress.com)
- One attractive notion is that pain signaling by trigeminal sensory neurons is potently regulated by the ambient levels of these peptides: CGRP is thought to facilitate neuronal firing responsible for trigeminal sensitization necessary to trigger headache, whereas BNP is proposed to act as a negative regulator of trigeminal neuron activity. (dovepress.com)
- Hence, the clinical goal of CGRP antagonism using either pharmacological receptor blockers or monoclonal antibodies (to sequester this peptide or to directly inhibit its receptor) is currently considered a novel approach for migraine prophylaxis and to treat acute headache attacks. (dovepress.com)
- The demonstrated pivotal role of calcitonin gene-related peptide (CGRP) has fostered the development of CGRP antagonists, unfortunately endowed with liver toxicity, and monoclonal antibodies (mAbs) toward circulating CGRP released during migraine attack or targeting its receptor. (frontiersin.org)
- Calcitonin gene related peptide (CGRP) is the most potent microvascular vasodilator known. (ahajournals.org)
- Calcitonin gene-related peptide (CGRP) evokes anxiety-like responses when infused into the lateral ventricle of rats. (jneurosci.org)
- Calcitonin gene-related peptide (CGRP) is one such peptide. (jneurosci.org)
- The aim of the present study is to explore functional consequences of migraine gene mutations on their responses to Calcitonin Gene Related Peptide (CGRP)infusion. (clinicaltrials.gov)
- Calcitonin Gene Related Peptide (CGRP) induces migraine attacks indistinguishable from spontaneous attacks in approximately 50% of migraine sufferers. (clinicaltrials.gov)
- Calcitonin gene-related peptide (CGRP) is a pivotal messenger in the inflammatory process in migraine. (mdpi.com)
- The objective of this study was to investigate the effects of foods and a dietary supplement on two migraine-related mechanisms in vitro: CGRP secretion from neuroendocrine CA77 cells, and calcium uptake by differentiated PC12 cells. (mdpi.com)
- To explore the role of anandamide (AEA) transporter in regulating calcitonin gene-related peptide (CGRP) production and blood pressure. (unboundmedicine.com)
- The neuropeptide calcitonin gene-related peptide (CGRP) expressed by one-third of rat dorsal root ganglion (DRG) neurons mediates pain sensation and vasodilation. (nih.gov)
- These drugs are the first to test monoclonal antibodies for migraine prevention and both target the protein calcitonin gene-related peptide (CGRP). (thedailyheadache.com)
- OBJECTIVE: The goal of this work was to investigate the efficacy of a calcitonin gene-related peptide (CGRP) slow-release tablet (CGRP tablet) for the prevention of cerebral vasospasm after subarachnoid hemorrhage (SAH). (biomedsearch.com)
- Substance P (SP), calcitonin gene-related peptide (CGRP), and isolectin B4 (IB4) are widely used as markers for peripheral neurons with unmyelinated fibers, whereas neurofilament 200 (NF200), and Peripherin are used as markers for neurons with myelinated fibers, and with unmyelinated or small-caliber fibers, respectively. (unboundmedicine.com)
- One of these mediators, calcitonin gene-related peptide (CGRP), is a neuropeptide released from nerve endings in the skin. (jimmunol.org)
- CGRP binds to its receptors composed of receptor activity-modifying protein 1 and calcitonin receptor-like receptor to modulate immune cell function. (jimmunol.org)
- As one of those molecules, calcitonin gene-related peptide (CGRP) and its immunoregulatory functions have been studied. (jimmunol.org)
- CGRP binds to its specific receptor composed of receptor activity-modifying protein 1 (RAMP1) and calcitonin receptor-like receptor (CLR) ( 3 ). (jimmunol.org)
- Effects of long-term treatment with angiotensin converting enzyme (ACE) inhibitor on decreased function of calcitonin gene-related peptide (CGRP)-containing vasodilator nerves (CGRP nerves) in mesenteric resistance artery were investigated in spontaneously hypertensive rats (SHR). (nii.ac.jp)
- 120 pmol kg-1 of CGRP was given to all the animals, the conscious animals receiving the peptide in one infusion lasting 4 min. (lu.se)
- The patterns shows a resemblance to that obtained in other species, but there are some marked differences, The tissues most susceptible to the peptide are those easily exposed to noxious stimuli and containing CGRP in the sensory nerve endings, observations in agreement with the proposed role for the peptide in neurogenic defence mechanisms. (lu.se)
- Purpose of review Monoclonal antibodies (mAbs) targeting the calcitonin-gene-related peptide (CGRP) pathway have been developed for episodic and chronic migraine prevention, either through binding the CGRP ligand (eptinezumab, fremanezumab, galcanezumab) or the CGRP receptor (erenumab). (eur.nl)
- Calcitonin gene-related peptide (CGRP), a potent vasodilatory and cardiotonic peptide, has a potential role for CGRP in diverse physiologic and pathophysiologic situations such as congestive heart failure, diabetes, migraine, and neurogenic inflammation. (aspetjournals.org)
- Although a peptide CGRP receptor antagonist, CGRP 8-37, is available, its utility presents significant limitations for these indications. (aspetjournals.org)
- Calcitonin gene-related peptide (CGRP) is a polypeptide produced by alternative processing of calcitonin gene transcripts and is endowed with important systemic physiological effects. (eurekaselect.com)
- Among other neuropeptides, sensory neurons contain calcitonin gene-related peptide (CGRP) and release CGRP in response to noxious stimulation. (ovid.com)
- Calcitonin gene-related peptide (CGRP) and substance P (SP) which is potent vasodilator neuropeptides play a counter-regulatory role in several models of experimental hypertension. (academicjournals.org)
- Langendorff-perfused mouse hearts (n = 328) were used to compare coronary flow rates among wild type (WT), a-CGRP gene knockout (KO) and NK1-KO mice under various pressure loading conditions (20, 30, 40 and 50 mmHg). (academicjournals.org)
- Deletion of a-CGRP gene resulted in a significant reduction in coronary flow rate for both genders at all pressures. (academicjournals.org)
- This effect seems to be gender related with less coronary flow noted in female WT and a-CGRP-KO mice, but not in NK1-KO mice. (academicjournals.org)
- In order to notably improve bone quality in RA patients for successful TJA surgery, we are investigating the role of calcitonin gene-related peptide (CGRP), a neuropeptide of the Calcitonin family. (egms.de)
- The involvement of calcitonin gene-related peptide (CGRP) in migraine pathophysiological mechanisms is shown by the facts that CGRP can induce migraine and that two CGRP antagonists, olcegepant and telcagepant, are effective in the treatment of migraine attacks. (nih.gov)
- Calcitonin gene-related peptide (CGRP) probably has a role in migraine pathophysiology, and antagonism of its receptors might provide treatment without the vasoconstrictor effects of triptans. (prohealth.com)
- Calcitonin gene-related peptide (CGRP) has recently been demonstrated in sensory neurons of the eye. (arvojournals.org)
- One of the potential pathways for prophylaxis involves Calcitonin Gene-Related Peptide (CGRP) modulation. (cpnp.org)
- We previously reported that endogenous prostaglandin I 2 , generated by a mild irritant, sensitised calcitonin gene related peptide (CGRP) containing sensory nerves and facilitated the release of CGRP and gastric mucosal protection against ethanol. (bmj.com)
- In cultured chicken myotubes, calcitonin gene-related peptide (CGRP), a peptide present in spinal cord motoneurons, increased by 1.5-fold the number of surface acetylcholine receptors (AChRs) and by threefold AChR alpha-subunit mRNA level without affecting the level of muscular alpha-actin mRNA. (rupress.org)
- These data suggest that distinct second messengers are involved in the regulation of AChR biosynthesis by CGRP and muscle activity and that these two pathways may contribute to the development of different patterns of AChR gene expression in junctional and extrajunctional areas of the muscle fiber. (rupress.org)
- Calcitonin gene-related peptide (CGRP) is known to be closely involved in the cascade of events that lead to a migraine attack. (headacheaustralia.org.au)
- These same brain structures cause peptides including CGRP, to be released. (headacheaustralia.org.au)
- Using an immunocytochemical technique, we have studied the distribution of fibers and cell bodies containing somatostatin-28 (1-12) [SOM-28 (1-12)], calcitonin gene-related peptide (CGRP), and substance P (SP) in the brainstem of Saimiri sciureus . (springer.com)
- Calcitonin gene-related peptide (CGRP) receptors were solubilized from rat cerebellum membranes in an active, stable, and guanine nucleotide-sensitive form by using digitonin. (aspetjournals.org)
- Global Markets Direct's, 'Calcitonin Gene Related Peptide (CGRP)- Pipeline Review, H2 2019', provides in depth analysis on Calcitonin Gene Related Peptide (CGRP) targeted pipeline therapeutics. (globalmarketsdirect.com)
- Additionally, the report provides an overview of key players involved in Calcitonin Gene Related Peptide (CGRP) targeted therapeutics development and features dormant and discontinued projects. (globalmarketsdirect.com)
- The report analyses the pipeline products from therapy areas Central Nervous System and Immunology under development targeting Calcitonin Gene Related Peptide (CGRP). (globalmarketsdirect.com)
- In such epithelia, LCs are in direct contact with peripheral neurons secreting calcitonin gene-related peptide (CGRP). (inserm.fr)
- Calcitonin gene-related peptide (CGRP) is a neuropeptide that has a variety of physiological functions. (arvojournals.org)
- Following Sep-pak extraction, calcitonin gene-related peptide immunoreactivity (CGRP-LI) was determined by radioimmunoassay in sample aliquots. (eurekamag.com)
- Several immu-no-his-to-chem-i-cal stud-ies con-duct-ed in the -acute -phase fol-low-ing SAH -have dem-on-strat-ed a -marked deple-tion of cer-tain pep-tides -like Substance P (SP), Calcitonin Gene Related Peptide (CGRP) -from the adven-ti-tia of per-i-vas-cu-lar -nerves. (minervamedica.it)
- To assess joint nociceptor activation indirectly, we used a novel in vitro knee joint preparation and determined the release of calcitonin gene-related peptide (CGRP) and prostaglandin E2 (PGE2) in osteoarthritic mice. (jrheum.org)
- The neuropeptide calcitonin gene-related peptide (CGRP) is concentrated in fine sensory nerve endings innervating all tissues, including bone. (galileo-training.com)
- To investigate the role of CGRP in bone in vivo, mice were engineered to express CGRP in osteoblasts by placing the human CGRP gene under the control of the rat osteocalcin promoter (Ost-CGRP tg+ mice). (galileo-training.com)
- It could be terminated by adding calcitonin-gene related peptide (CGRP), most likely because CGRP causes ET-1/ETAR dissociation. (eur.nl)
- Calcitonin gene-related peptide (CGRP) is an endogenous neuropeptide that exhibits anti-inflammatory, anti-resorptive, anxiogenic, neuroprotective, and pro-angiogenic activities. (lktlabs.com)
- The neuropeptide calcitonin gene-related peptide (CGRP) prevents inflammatory liver injury in mice. (lktlabs.com)
- The effects of long-term administration of paclitaxel on the function of sensory neurons grown in culture, using the release of the neuropeptide calcitonin gene-related peptide (CGRP) as an endpoint of sensory neuronal function, were examined. (iupui.edu)
- The aim of this study was to investigate whether expression of γ-aminobutyric acid (GABA) and the neuropeptides substance P (SP) and calcitonin gene-related peptide (CGRP) in the primary sensory neurons of cervical dorsal root ganglia (DRG) are involved in electroacupuncture (EA)-induced analgesia in a rat model of incisional neck pain. (bmj.com)
- Conclusions EA at LI18/LI4-PC6 increases PT in rats with incisional neck pain, which is likely related to downregulation of pronociceptive mediators SP/CGRP and upregulation of the inhibitory transmitter GABA in the primary sensory neurons of cervical DRGs. (bmj.com)
- Peptide-Human Calcitonin Gene Related Peptide (CGRP) Control/blocking peptide #1-Alpha Diagnostic International Inc. (4adi.com)
- The co-expression of ASIC3 with calcitonin gene-related peptide (CGRP) or parvalbumin (PV) was examined in the trigeminal ganglion (TG) by a double immunofluorescence method. (semanticscholar.org)
- MBS029789 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Calcitonin Gene Related Peptide (CGRP) ELISA Kit target analytes in biological samples. (mybiosource.com)
- NCBI/Uniprot data below describe general gene information for CGRP . (mybiosource.com)
- Calcitonin gene-related peptide (CGRP) has been reported to play an important role in the proliferation of various types of epithelial and endothelial cells. (biomedcentral.com)
- Calcitonin gene-related peptide (CGRP) is a target for cardiovascular gene therapy. (elsevier.com)
- To determine the feasibility of adenoviral-mediated CGRP gene transfer into ex vivo-expanded MSCs, rat MSCs were isolated, ex vivo expanded, and transduced with adenoviruses. (elsevier.com)
- Adprepro-CGRP and AdntlacZ, adenoviral vectors containing prepro-CGRP or nuclear-targeted β-galactosidase reporter gene ntlacZ under the control of Rous sarcoma virus promoter, were used. (elsevier.com)
- These findings suggest that replication-deficient recombinant adenovirus can be used to gene engineer ex vivo-expanded MSCs and that high-level secretion of biologically active CGRP can be achieved, underscoring the clinical potential of using this novel adult stem cell-based cell and gene therapy strategy for the treatment of cardiovascular diseases. (elsevier.com)
- We investigated the protein and mRNA expression of calcitonin gene-related peptide (CGRP) in endothelial cells of the rat thoracic aorta and femoral artery. (um.es)
- In the present study, we explored the mechanisms of possible involvement and regulation of substance P (SP) and calcitonin gene-related peptide (CGRP) in the pathological and inflammatory processes of arthritis in DDH. (biomedcentral.com)
- Radiographs depicting moderate developmental dysplasia of the hip (DDH) (A) and severe DDH (B) . mRNA expression of substance P (SP) (C) and calcitonin gene-related peptide (CGRP) (D) in synovial tissues obtained from patients in the study groups: moderate DDH ( n = 10), severe DDH ( n = 11) and control ( n = 8). (biomedcentral.com)
- Calcitonin gene-related peptide (CGRP), a neuropeptide, is a naturally occurring vasodilator with no constrictive effects. (elsevier.com)
- Protons can release in a Ca(2+)-dependent manner, calcitonin gene-related peptide (CGRP)-like immunoreactivity from peripheral endings of capsaicin-sensitive afferents. (mysciencework.com)
- Transient hyperthermic shifts in body temperature have been linked to the endogenous hormone calcitonin gene-related peptide (CGRP), which can increase sympathetic activation and metabolic heat production. (biomedcentral.com)
- A study was carried out to investigate the role of the calcitonin gene-related peptide (CGRP) in the regulation of electrolyte transport in the rat and human epididymis. (hku.hk)
- Calcitonin had no effect on the SCC and did not affect the CGRP-induced rise in the SCC. (hku.hk)
- Anti-Calcitonin Gene-Related Peptide (CGRP) Therapies: Update on a Previous Review After the American Headache Society 60th Scientific Meeting, San Francisco, June 2018. (jefferson.edu)
- History and Review of anti-Calcitonin Gene-Related Peptide (CGRP) Therapies: From Translational Research to Treatment. (jefferson.edu)
- Middle cerebral artery (MCA) diameter is regulated by inherent myogenic activity and the effect of potent vasodilators such as calcitonin gene-related peptide (CGRP). (ku.dk)
- This assay has high sensitivity and excellent specificity for detection of Calcitonin Gene Related Peptide (CGRP). (cloud-clone.com)
- No significant cross-reactivity or interference between Calcitonin Gene Related Peptide (CGRP) and analogues was observed. (cloud-clone.com)
- Matrices listed below were spiked with certain level of recombinant Calcitonin Gene Related Peptide (CGRP) and the recovery rates were calculated by comparing the measured value to the expected amount of Calcitonin Gene Related Peptide (CGRP) in samples. (cloud-clone.com)
- Intra-assay Precision (Precision within an assay): 3 samples with low, middle and high level Calcitonin Gene Related Peptide (CGRP) were tested 20 times on one plate, respectively. (cloud-clone.com)
- Inter-assay Precision (Precision between assays): 3 samples with low, middle and high level Calcitonin Gene Related Peptide (CGRP) were tested on 3 different plates, 8 replicates in each plate. (cloud-clone.com)
- The linearity of the kit was assayed by testing samples spiked with appropriate concentration of Calcitonin Gene Related Peptide (CGRP) and their serial dilutions. (cloud-clone.com)
- Should the Human Calcitonin Gene Related Peptide (CGRP) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement. (novosides.eu)
- Description: A competitive inhibition quantitative ELISA assay kit for detection of Human Calcitonin Gene Related Peptide (CGRP) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. (novosides.eu)
- Description: This is Competitive Enzyme-linked immunosorbent assay for detection of Mouse Calcitonin Gene Related Peptide (CGRP) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids. (novosides.eu)
Adrenomedullin6
- Following sections of the book deal with the biochemistry, physiology and pharmacology of receptors for the allied peptides amylin and adrenomedullin. (routledge.com)
- Brain SD, Grant AD (2004) Vascular actions of calcitonin gene-related peptide and adrenomedullin. (springer.com)
- Adrenomedullin is a vasodilatatory peptide, which is constitutivly produced by endothelial cells and act on the CRLR receptor. (hu-berlin.de)
- The association of CALCRL with different RAMP proteins produces different receptors which with RAMP1 acts as a receptor for calcitonin-gene-related peptide, with RAMP2 acts as a receptor for adrenomedullin-1and with RAMP3 act as a receptor for adrenomedullin-2. (asdreports.com)
- However, no significant sequence homology is detected with calcitonin or adrenomedullin. (4adi.com)
- The calcitonin family of bioactive peptides comprises of calcitonin, amylin, two calcitonin-gene related peptides (CGRP1, and CGRP2) and adrenomedullin (ADM). (4adi.com)
Receptors7
- The close connections between amylin and calcitonin receptors are highlighted and role of amylin in the regulation of food intake is then considered. (routledge.com)
- Receptors, Calcitonin Gene-Related Peptide" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)
- This graph shows the total number of publications written about "Receptors, Calcitonin Gene-Related Peptide" by people in this website by year, and whether "Receptors, Calcitonin Gene-Related Peptide" was a major or minor topic of these publications. (umassmed.edu)
- Below are the most recent publications written about "Receptors, Calcitonin Gene-Related Peptide" by people in Profiles. (umassmed.edu)
- SB-(+)-273779 tested at 3 μM had no significant affinity for calcitonin, endothelin, angiotensin II, and α-adrenergic receptors under standard ligand binding assays. (aspetjournals.org)
- The released peptides bind to specific receptors which cause sensitization. (headacheaustralia.org.au)
- Critical role of calcitonin gene-related peptide receptors in cortical spreading depression. (painresearchforum.org)
Neuropeptide2
- Amara SG, Arriza JL, Leff SE, Swanson LW, Evans RM, Rosenfend MG (1985) Expression in brain of a messenger RNA encoding a novel neuropeptide homologous to calcitonin gene related peptide. (springer.com)
- It is a neuropeptide of 37 amino acids with structural homology to salmon calcitonin . (biology-online.org)
Alpha-Calcitonin gene-re1
- alpha-Calcitonin gene-related peptide (alphaCGRP) is released mainly from sensory and motor nerves in response to physiological stimuli. (garvan.org.au)
Vasodilator4
- It is a potent peptide vasodilator and can function in the transmission of nociception. (wikipedia.org)
- Brain SD, Williams TJ, Tippings JR, Morris HR, MacIntyre I (1985) Calcitonin gene related peptide is a potent vasodilator. (springer.com)
- 4. The present findings lend further support to the theory of regional variation in the vasodilator response to calcitonin-gene-related peptide in porcine coronary arteries, which seems to be due to different densities of a single type of receptor for calcitonin-gene-related peptide. (clinsci.org)
- Calcitonin Gene-Related Peptide-I, Human, CAS 90954-53-3, is a potent and long-acting vasodilator. (merckmillipore.com)
Neurons3
- For either peptide, the key target appears to be the ATP-gated P2X3 receptor that, widely expressed by trigeminal sensory neurons, generates fast, large excitation to release glutamate onto second-order brain neurons. (dovepress.com)
- The receptor for a peptide found in trigeminal nerve sensory neurons which is a powerful dilator of cerebral and dural arteries. (thefreedictionary.com)
- Debas, H. T. / A role for calcitonin gene-related peptide-containing neurons in gastric cytoprotection . (elsevier.com)
Immunoreactivity1
- Batten TF, Lo VK, Maqbool A, McWilliam PN (1989) Distribution of calcitonin gene-related peptide-like immunoreactivity in the medulla oblongata of the cat, in relation to choline acetyltransferase-immunoreactive motoneurones and substance P-immunoreactive fibers. (springer.com)
HUMAN Calcitonin1
- β-Human calcitonin-gene-related peptide showed higher affinity than α-human calcitonin-gene-related peptide for the binding sites. (clinsci.org)
Polypeptide1
- Amara SG, Jonas V, Rosenfeld MG, Ong ES, Evans RM (1982) Alternative RNA processing in calcitonin gene expression generates mRNAs encoding different polypeptide products. (springer.com)
Sensory2
- Increased content and transport of substance P and calcitonin gene-related peptide in sensory nerves innervating inflamed tissue: evidence for a regulatory function of nerve growth factor in vivo. (semanticscholar.org)
- Low pH-induced release of calcitonin gene-related peptide from capsaicin-sensitive sensory nerves: mechanism of action and biological response. (mysciencework.com)
Monoclonal1
- Further controlled studies are needed to assess the safety and efficacy of monoclonal calcitonin gene-related peptide antibodies for the preventive treatment of migraine. (elsevier.com)
Endogenous1
- Pathophysiological roles of endogenous calcitonin gene-related peptide in mouse model of laser induced choroidal neovascularization. (arvojournals.org)
Amino acids2
- The difference between a peptide and a protein is the number of amino acids it contains. (headacheaustralia.org.au)
- Generally speaking when a molecule contains 2-50 amino acids it is considered a peptide. (headacheaustralia.org.au)
Pharmacology1
- The work is aimed at the specialist in the field, but it is hoped that many of the chapters will also prove useful as introductions to those wishing to gain greater familiarity with the biology and pharmacology of these important peptides. (routledge.com)
Antagonist4
- An infusion of the calcitonin gene-related peptide will induce MIGRAINE and the specific antagonist BIBN 4096 BS is effective in treating an attack of migraine. (thefreedictionary.com)
- Biohaven Pharmaceutical announced that positive results from a Phase 3 pivotal clinical trial of rimegepant, Biohaven's small molecule calcitonin gene-related peptide receptor antagonist, for the acute treatment of migraine, are published in the July 12, 2019 issue of the New England Journal of Medicine. (thefreedictionary.com)
- Biohaven Pharmaceutical announced additional safety and preliminary efficacy results from its ongoing long-term, open-label safety study of its oral calcitonin gene-related peptide receptor antagonist, rimegepant. (thefreedictionary.com)
- Biohaven Pharmaceutical is presenting expanded data from two randomized, pivotal Phase 3 clinical trials of rimegepant, Biohaven's small molecule calcitonin gene-related peptide receptor antagonist, on June 30 at the American Headache Society Annual Scientific Meeting. (thefreedictionary.com)
MRNA2
- It occurs as a result of alternative processing of mRNA from the calcitonin gene. (jove.com)
- Calcitonin gene-related peptide and muscle activity regulate acetylcholine receptor alpha-subunit mRNA levels by distinct intracellular pathways. (rupress.org)
Substance1
- After five days of inflammation, the substance P and calcitonin gene-related peptide content in the sciatic nerve supplying the inflamed paw were increased by 60-75% when compared with the contralateral side. (semanticscholar.org)
Antibodies1
- Control or blocking peptides are recommended for ELISA plate coating for direct ELISA testing of antibodies or competitive ELISA, and antibody blocking or neutralization. (4adi.com)
Synthesis1
- Calcitonin gene-related peptide regulates muscle acetylcholine receptor synthesis. (nih.gov)
Pathways1
- The consequence of migraine gene mutations on relevant migraine pathways has never been tested. (clinicaltrials.gov)
Antagonism1
- Calcitonin gene-related peptide antagonism and cluster headache: an emerging new treatment. (painresearchforum.org)
Gastric2
- The exogenous administration of the peptide was able to afford protection against experimental ulcers induced by an increase in gastric secretion. (eurekaselect.com)
- S. Evangelista, " Role of Calcitonin Gene-Related Peptide in Gastric Mucosal Defence and Healing", Current Pharmaceutical Design (2009) 15: 3571. (eurekaselect.com)
Subarachnoid hemorrhage1
- Prevention of cerebral vasospasm by calcitonin gene-related peptide slow-release tablet after subarachnoid hemorrhage in monkeys. (biomedsearch.com)
CGRPs1
- Prophylactic therapy with calcitonin gene‐related peptides (CGRPs) may have unknown fertility consequences for women of child bearing age. (wikipedia.org)
Ischemia2
- Calcitonin gene-related peptide facilitates revascularization during hindlimb ischemia in mice. (lktlabs.com)
- Calcitonin gene-related peptide in experimental ischemia. (elsevier.com)
Cluster headache3
- Calcitonin gene-related peptide in blood: is it increased in the external jugular vein during migraine and cluster headache? (nih.gov)
- Cluster Headache and Calcitonin Gene-Related Peptide-More on Quantum Therapeutics in Headache Medicine. (painresearchforum.org)
- Effect of Infusion of Calcitonin Gene-Related Peptide on Cluster Headache Attacks: A Randomized Clinical Trial. (painresearchforum.org)
Responses2
- Reviewing this growing literature, we have suggested that the BNST participates preferentially in sustained but not phasic threat responses-a pattern complementary to that of the closely related medial division of the central amygdala nucleus. (jneurosci.org)
- These responses were dose-related. (arvojournals.org)
Receptor called1
- It works by blocking a receptor called the calcitonin gene-related peptide receptor which plays a critical role in mediating the incapacitating pain of migraine. (thefreedictionary.com)
Thyroid2
Affinity1
- Cell surface proteins that bind CALCITONIN GENE-RELATED PEPTIDE with high affinity and trigger intracellular changes which influence the behavior of cells. (umassmed.edu)
Expression3
- Changes in the expression of calcitonin gene-related peptide after exposure to stretch-shortening contractions. (cdc.gov)
- In this study, it can be shown that transduction efficiency of adenoviral-mediated gene transfer into ex vivo-expanded MSCs is dose dependent, transgene expression persists for more than 21 days in culture, and adenoviral transduction does not alter the proliferation or viability of MSCs. (elsevier.com)
- Previous studies showed that MCAs express KCNQ1, 4, and 5 potassium channel genes, and the expression products (Kv7 channels) participate in the myogenic control of MCA diameter. (ku.dk)
Neurotransmitter1
- The peptide produces multiple biological effects and has both circulatory and neurotransmitter modes of action. (jove.com)
Hypertension1
- TY - JOUR T1 - Role of anandamide transporter in regulating calcitonin gene-related peptide production and blood pressure in hypertension. (unboundmedicine.com)
Homologous1
- A portion of the B-chain of insulin is strongly homologous to these four peptides. (nih.gov)
Antibody1
- Calcitonin Gene Related Peptide, anti_rat IgG antibody storage GENTAUR recommends for long therm storage to freeze at -24 C. For short time storage up to 30 days we suggest fridge storage at 1 to 10 C. Prevent multiple freeze taw cycles of Calcitonin Gene Related Peptide, anti_rat IgG. (antibody-antibodies.com)
19911
- Ardvisson U, Ulfhake B, Cullheim S, Terenius L, Hökfelt T (1991) Calcitonin gene-related peptide in the monkey spinal cord and medulla oblongata. (springer.com)
Protein-coupled receptor1
- Calcitonin Gene Related Peptide Type 1 Receptor (Calcitonin Receptor Like Receptor or CALCRL) - Calcitonin receptor-like (CALCRL) also known as the calcitonin receptor-like receptor (CRLR) is a G protein-coupled receptor. (asdreports.com)
Coronary artery2
- Most of the specific binding sites for both peptides in the large coronary artery were localized in the intima and media. (clinsci.org)
- This peptide inhibits retinal apoptosis in retinal cells in animal models of coronary artery occlusion. (lktlabs.com)
Inhibits1
- Calcitonin gene-related peptide inhibits Langerhans cell-mediated HIV-1 transmission. (inserm.fr)