Calcitonin: A peptide hormone that lowers calcium concentration in the blood. In humans, it is released by thyroid cells and acts to decrease the formation and absorptive activity of osteoclasts. Its role in regulating plasma calcium is much greater in children and in certain diseases than in normal adults.Calcitonin Gene-Related Peptide: Calcitonin gene-related peptide. A 37-amino acid peptide derived from the calcitonin gene. It occurs as a result of alternative processing of mRNA from the calcitonin gene. The neuropeptide is widely distributed in neural tissue of the brain, gut, perivascular nerves, and other tissue. The peptide produces multiple biological effects and has both circulatory and neurotransmitter modes of action. In particular, it is a potent endogenous vasodilator.Receptors, Calcitonin: Cell surface proteins that bind calcitonin and trigger intracellular changes which influence the behavior of cells. Calcitonin receptors outside the nervous system mediate the role of calcitonin in calcium homeostasis. The role of calcitonin receptors in the brain is not well understood.Receptors, Calcitonin Gene-Related Peptide: Cell surface proteins that bind CALCITONIN GENE-RELATED PEPTIDE with high affinity and trigger intracellular changes which influence the behavior of cells. CGRP receptors are present in both the CENTRAL NERVOUS SYSTEM and the periphery. They are formed via the heterodimerization of the CALCITONIN RECEPTOR-LIKE PROTEIN and RECEPTOR ACTIVITY-MODIFYING PROTEIN 1.Calcitonin Receptor-Like Protein: A receptor protein that is associated with RECEPTOR ACTIVITY-MODIFYING PROTEINS. When bound to RECEPTOR ACTIVITY-MODIFYING PROTEIN 1 it forms the CALCITONIN GENE-RELATED RECEPTOR. When bound to RECEPTOR ACTIVITY-MODIFYING PROTEIN 2 or RECEPTOR ACTIVITY-MODIFYING PROTEIN 3 it forms the ADRENOMEDULLIN RECEPTOR.Receptor Activity-Modifying Proteins: A family of proteins that bind to CELL SURFACE RECEPTORS and alter their specificity, signaling mechanism, or mode of intracellular transport.Receptor Activity-Modifying Protein 1: A receptor activity-modifying protein that is a subunit of specific G-PROTEIN COUPLED RECEPTORS. The CALCITONIN GENE-RELATED PEPTIDE RECEPTOR is formed from a dimer of this protein and CALCITONIN RECEPTOR-LIKE PROTEIN, while an isoform of the ISLET AMYLOID POLYPEPTIDE RECEPTOR is formed from this protein dimerizing with the CALCITONIN RECEPTOR.Adrenomedullin: A 52-amino acid peptide with multi-functions. It was originally isolated from PHEOCHROMOCYTOMA and ADRENAL MEDULLA but is widely distributed throughout the body including lung and kidney tissues. Besides controlling fluid-electrolyte homeostasis, adrenomedullin is a potent vasodilator and can inhibit pituitary ACTH secretion.Salmon: Fish of the genera ONCORHYNCHUS and Salmo in the family SALMONIDAE. They are anadromous game fish, frequenting the coastal waters of both the North Atlantic and Pacific. They are known for their gameness as a sport fish and for the quality of their flesh as a table fish. (Webster, 3d ed).Receptor Activity-Modifying Protein 2: A receptor activity-modifying protein that heterodimerizes with CALCITONIN RECEPTOR-LIKE PROTEIN to form the ADRENOMEDULLIN RECEPTOR. In addition, an isoform of the ISLET AMYLOID POLYPEPTIDE RECEPTOR is formed from this protein dimerizing with the CALCITONIN RECEPTOR.Receptor Activity-Modifying Protein 3: A receptor activity-modifying protein that heterodimerizes with CALCITONIN RECEPTOR-LIKE PROTEIN to form the ADRENOMEDULLIN RECEPTOR. In addition, an isoform of the ISLET AMYLOID POLYPEPTIDE RECEPTOR is formed from this protein dimerizing with the CALCITONIN RECEPTOR.Receptors, Islet Amyloid Polypeptide: G-protein coupled receptors that are formed through the dimerization of the CALCITONIN RECEPTOR with a RECEPTOR ACTIVITY-MODIFYING PROTEIN. Their affinity for ISLET AMYLOID POLYPEPTIDE is dependent upon which of several receptor activity-modifying protein subtypes they are bound to.Substance P: An eleven-amino acid neurotransmitter that appears in both the central and peripheral nervous systems. It is involved in transmission of PAIN, causes rapid contractions of the gastrointestinal smooth muscle, and modulates inflammatory and immune responses.Receptors, Adrenomedullin: G-protein-coupled cell surface receptors for ADRENOMEDULLIN. They are formed by the heterodimerization of CALCITONIN RECEPTOR-LIKE PROTEIN and either RECEPTOR ACTIVITY-MODIFYING PROTEIN 2 or RECEPTOR ACTIVITY-MODIFYING PROTEIN 3.Carcinoma, Medullary: A carcinoma composed mainly of epithelial elements with little or no stroma. Medullary carcinomas of the breast constitute 5%-7% of all mammary carcinomas; medullary carcinomas of the thyroid comprise 3%-10% of all thyroid malignancies. (From Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1141; Segen, Dictionary of Modern Medicine, 1992)Capsaicin: An alkylamide found in CAPSICUM that acts at TRPV CATION CHANNELS.Thyroid Neoplasms: Tumors or cancer of the THYROID GLAND.Neuropeptides: Peptides released by NEURONS as intercellular messengers. Many neuropeptides are also hormones released by non-neuronal cells.Ultimobranchial Body: A diverticulum from the fourth pharyngeal pouch of an embryo, regarded by some as a rudimentary fifth pharyngeal pouch and by others as a lateral thyroid primordium. The ultimobranchial bodies of lower vertebrates contain large amounts of calcitonin. In mammals the bodies fuse with the thyroid gland and are thought to develop into the parafollicular cells. (Stedman, 25th ed)Eels: Common name for an order (Anguilliformes) of voracious, elongate, snakelike teleost fishes.Osteitis Deformans: A disease marked by repeated episodes of increased bone resorption followed by excessive attempts at repair, resulting in weakened, deformed bones of increased mass. The resultant architecture of the bone assumes a mosaic pattern in which the fibers take on a haphazard pattern instead of the normal parallel symmetry.Thyroidectomy: Surgical removal of the thyroid gland. (Dorland, 28th ed)Parathyroid Hormone: A polypeptide hormone (84 amino acid residues) secreted by the PARATHYROID GLANDS which performs the essential role of maintaining intracellular CALCIUM levels in the body. Parathyroid hormone increases intracellular calcium by promoting the release of CALCIUM from BONE, increases the intestinal absorption of calcium, increases the renal tubular reabsorption of calcium, and increases the renal excretion of phosphates.Pentagastrin: A synthetic pentapeptide that has effects like gastrin when given parenterally. It stimulates the secretion of gastric acid, pepsin, and intrinsic factor, and has been used as a diagnostic aid.Cyclic AMP: An adenine nucleotide containing one phosphate group which is esterified to both the 3'- and 5'-positions of the sugar moiety. It is a second messenger and a key intracellular regulator, functioning as a mediator of activity for a number of hormones, including epinephrine, glucagon, and ACTH.Miotics: Agents causing contraction of the pupil of the eye. Some sources use the term miotics only for the parasympathomimetics but any drug used to induce miosis is included here.Thyroid Gland: A highly vascularized endocrine gland consisting of two lobes joined by a thin band of tissue with one lobe on each side of the TRACHEA. It secretes THYROID HORMONES from the follicular cells and CALCITONIN from the parafollicular cells thereby regulating METABOLISM and CALCIUM level in blood, respectively.Receptors, Peptide: Cell surface receptors that bind peptide messengers with high affinity and regulate intracellular signals which influence the behavior of cells.Islet Amyloid Polypeptide: A pancreatic beta-cell hormone that is co-secreted with INSULIN. It displays an anorectic effect on nutrient metabolism by inhibiting gastric acid secretion, gastric emptying and postprandial GLUCAGON secretion. Islet amyloid polypeptide can fold into AMYLOID FIBRILS that have been found as a major constituent of pancreatic AMYLOID DEPOSITS.Rats, Sprague-Dawley: A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.Bone Resorption: Bone loss due to osteoclastic activity.Neurons, Afferent: Neurons which conduct NERVE IMPULSES to the CENTRAL NERVOUS SYSTEM.Radioimmunoassay: Classic quantitative assay for detection of antigen-antibody reactions using a radioactively labeled substance (radioligand) either directly or indirectly to measure the binding of the unlabeled substance to a specific antibody or other receptor system. Non-immunogenic substances (e.g., haptens) can be measured if coupled to larger carrier proteins (e.g., bovine gamma-globulin or human serum albumin) capable of inducing antibody formation.Trigeminal Ganglion: The semilunar-shaped ganglion containing the cells of origin of most of the sensory fibers of the trigeminal nerve. It is situated within the dural cleft on the cerebral surface of the petrous portion of the temporal bone and gives off the ophthalmic, maxillary, and part of the mandibular nerves.Calcium: A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.Hypocalcemia: Reduction of the blood calcium below normal. Manifestations include hyperactive deep tendon reflexes, Chvostek's sign, muscle and abdominal cramps, and carpopedal spasm. (Dorland, 27th ed)Osteoclasts: A large multinuclear cell associated with the BONE RESORPTION. An odontoclast, also called cementoclast, is cytomorphologically the same as an osteoclast and is involved in CEMENTUM resorption.Vasoactive Intestinal Peptide: A highly basic, 28 amino acid neuropeptide released from intestinal mucosa. It has a wide range of biological actions affecting the cardiovascular, gastrointestinal, and respiratory systems and is neuroprotective. It binds special receptors (RECEPTORS, VASOACTIVE INTESTINAL PEPTIDE).Ganglia, Spinal: Sensory ganglia located on the dorsal spinal roots within the vertebral column. The spinal ganglion cells are pseudounipolar. The single primary branch bifurcates sending a peripheral process to carry sensory information from the periphery and a central branch which relays that information to the spinal cord or brain.Calcium Gluconate: The calcium salt of gluconic acid. The compound has a variety of uses, including its use as a calcium replenisher in hypocalcemic states.Peptide Fragments: Partial proteins formed by partial hydrolysis of complete proteins or generated through PROTEIN ENGINEERING techniques.Nerve Fibers: Slender processes of NEURONS, including the AXONS and their glial envelopes (MYELIN SHEATH). Nerve fibers conduct nerve impulses to and from the CENTRAL NERVOUS SYSTEM.Bone Density Conservation Agents: Agents that inhibit BONE RESORPTION and/or favor BONE MINERALIZATION and BONE REGENERATION. They are used to heal BONE FRACTURES and to treat METABOLIC BONE DISEASES such as OSTEOPOROSIS.Dose-Response Relationship, Drug: The relationship between the dose of an administered drug and the response of the organism to the drug.Trigeminal Nerve: The 5th and largest cranial nerve. The trigeminal nerve is a mixed motor and sensory nerve. The larger sensory part forms the ophthalmic, mandibular, and maxillary nerves which carry afferents sensitive to external or internal stimuli from the skin, muscles, and joints of the face and mouth and from the teeth. Most of these fibers originate from cells of the TRIGEMINAL GANGLION and project to the TRIGEMINAL NUCLEUS of the brain stem. The smaller motor part arises from the brain stem trigeminal motor nucleus and innervates the muscles of mastication.Neurokinin A: A mammalian neuropeptide of 10 amino acids that belongs to the tachykinin family. It is similar in structure and action to SUBSTANCE P and NEUROKININ B with the ability to excite neurons, dilate blood vessels, and contract smooth muscles, such as those in the BRONCHI.RNA, Messenger: RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.Hydroxyproline: A hydroxylated form of the imino acid proline. A deficiency in ASCORBIC ACID can result in impaired hydroxyproline formation.Peptides: Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.Rats, Wistar: A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.Neuropeptide Y: A 36-amino acid peptide present in many organs and in many sympathetic noradrenergic neurons. It has vasoconstrictor and natriuretic activity and regulates local blood flow, glandular secretion, and smooth muscle activity. The peptide also stimulates feeding and drinking behavior and influences secretion of pituitary hormones.Hypercalcemia: Abnormally high level of calcium in the blood.Vasodilation: The physiological widening of BLOOD VESSELS by relaxing the underlying VASCULAR SMOOTH MUSCLE.Bone and Bones: A specialized CONNECTIVE TISSUE that is the main constituent of the SKELETON. The principle cellular component of bone is comprised of OSTEOBLASTS; OSTEOCYTES; and OSTEOCLASTS, while FIBRILLAR COLLAGENS and hydroxyapatite crystals form the BONE MATRIX.Immunohistochemistry: Histochemical localization of immunoreactive substances using labeled antibodies as reagents.Migraine Disorders: A class of disabling primary headache disorders, characterized by recurrent unilateral pulsatile headaches. The two major subtypes are common migraine (without aura) and classic migraine (with aura or neurological symptoms). (International Classification of Headache Disorders, 2nd ed. Cephalalgia 2004: suppl 1)Hormones, Ectopic: Hormones released from neoplasms or from other cells that are not the usual sources of hormones.

Disruption of estrogen signaling does not prevent progesterone action in the estrogen receptor alpha knockout mouse uterus. (1/1409)

Estrogen is known to increase progesterone receptor (PR) levels in the wild-type mouse uterus, and this estrogen induction was thought to be important for progesterone action through the PR. The estrogen receptor alpha knockout (ERKO) mouse uterus was observed to express PR mRNA that cannot be induced by estrogen. Progesterone action was characterized to determine whether it was diminished in ERKO mice. The PR protein is present in the ERKO uterus at 60% of the level measured in a wild-type uterus. The PR-A and PR-B isoforms are both detected on Western blot, and the ratio of isoforms is the same in both genotypes. Although the level of PR is reduced in the ERKO uterus, the receptor level is sufficient to induce genomic responses, since both calcitonin and amphiregulin mRNAs were increased after progesterone treatment. Finally, the ERKO uterus can be induced to undergo a progesterone-dependent decidual response. Surprisingly, the decidual response is estrogen independent in the ERKO, although it remains estrogen dependent in a wild type. These results indicate that estrogen receptor alpha modulation of PR levels is not necessary for expression of the PR or genomic and physiologic responses to progesterone in the ERKO uterus.  (+info)

A prospective study of bone loss and turnover after allogeneic bone marrow transplantation: effect of calcium supplementation with or without calcitonin. (2/1409)

Transplantation of solid organs including heart, kidney, and liver is associated with rapid bone loss and increased rate of fracture; data on bone marrow transplantation recipients (BMT) are scarce. The purpose of the present study was to examine the magnitude, timing, and mechanism of bone loss following allogeneic BMT, and to study whether bone loss can be prevented by calcium with or without calcitonin. Sixty-nine patients undergoing allogeneic BMT for malignant blood diseases were enrolled into the study. Forty-four (22 women, 22 men) completed 6 months, and 36 patients 1 year follow-up. They were randomized to receive either no additional treatment (n = 22), or oral calcium 1 g twice daily for 12 months (n = 12) or the same dose of calcium plus intranasal calcitonin 400 IU/day for the first month and then 200 IU/day for 11 months (n = 10). Bone mineral density (BMD) at the lumbar spine and three femoral sites (femoral neck, trochanter, Ward's triangle) was measured by dual-energy X-ray absorptiometry (DXA). Bone turnover rate was followed with markers of bone formation and resorption (serum bone-specific alkaline phosphatase (B-ALP), type I procollagen carboxyterminal (PICP) and aminoterminal propeptide (PINP), serum type I collagen carboxyterminal telopeptide (ICTP)). Serum testosterone was assayed in men. Calcium with or without calcitonin had no effect on bone loss or bone markers; consequently the three study groups were combined. During the first 6 post-transplant months BMD decreased by 5.7% in the lumbar spine and by 6.9% to 8.7% in the three femoral sites (P < 0.0001 for all); no significant further decline occured between 6 and 12 months. Four out of 25 assessable patients experienced vertebral compression fractures. Markers of bone formation reduced: B-ALP by 20% at 3 weeks (P = 0.027), PICP by 40% (P < 0.0001) and PINP by 63% at 6 weeks (P < 0.0001), with a return to baseline by 6 months. The marker of bone resorption, serum ICTP was above normal throughout the whole observation period, with a peak at 6 weeks (77% above baseline, P < 0.0001). In male patients serum testosterone decreased reaching a nadir (57% below baseline) at 6 weeks (P = 0.0003). In conclusion, significant bone loss occurs after BMT. It results from imbalance between reduced bone formation and increased bone resorption; hypogonadism may be a contributing factor in men. Bone loss can not be prevented by calcium with or without calcitonin.  (+info)

Study of the cell biology and biochemistry of cherubism. (3/1409)

AIMS: To establish whether the multinucleate cells in lesions of patients with cherubism are also osteoclasts and if this is the case whether they were responsive to calcitonin; to carry out cytogenetic studies on two members of the same family affected by cherubism in an attempt to identify any major chromosomal defects; and to perform an in-depth modern biochemical study of four children in the same family. SUBJECTS AND METHODS: Four related children with cherubism were studied. Tissue taken from one of the children at elective decompression of an optic nerve was submitted to in vitro bone resorption studies. Cytogenetic studies were done on two of the children and biochemical studies on all four. RESULTS: The multinucleate cells in the cherubic lesions were shown to be osteoclasts since they synthesised tartrate resistant acid phosphatase, expressed the vitronectin receptor, and resorbed bone. Bone resorption by the cultured multinucleate cells was significantly inhibited by calcitonin. High resolution cytogenetic studies failed to detect any chromosomal abnormalities in two children with cherubism. The biochemistry profile of all four children with cherubism showed that serum calcium, parathyroid hormone, parathyroid related hormone, calcitonin, and alkaline phosphatase were within normal levels. Urine analysis of pyridinium and deoxypyridinium cross links, hydroxyproline, and calcium in relation to urine creatinine were measured to assess bone resorption in these children, and the values were at the upper end of the normal range in all four. CONCLUSIONS: Further studies are required to determine whether calcitonin treatment will control this grossly deforming disease until the time when the physiological changes that occur at puberty rectify the pathology. It is not recommended that biochemical markers of bone resorption are used in isolation to monitor the activity of cherubism in individuals because the results are based on a small number of children and because of reports of marked interindividual variation in the levels of these markers, particularly in children.  (+info)

Gastroenteropancreatic neuroendocrine tumor metastases to the thyroid gland: differential diagnosis with medullary thyroid carcinoma. (4/1409)

Neuroendocrine tumors (NET) of the thyroid gland are rare. Apart from medullary thyroid carcinoma (MTC), metastases of gastroenteropancreatic (GEP) NET may also occur. Features of six patients (five men, one female: age range, 39-67 years) with thyroid metastases from a GEP-NET are described. Thyroid metastases were bilateral in all patients and were associated with enlarged neck lymph nodes in five. In four cases, the thyroid tumor was either the first sign of the disease (n = 2) or was an isolated site of recurrence (n = 2). The tumors were well (n = 3) or poorly differentiated (n = 3). Five tumors for which the primary site could be determined corresponded to foregut-derived tumors (3 lungs, 1 thymus and 1 pancreatic NET). One tumor demonstrated calcitonin (CT) production as shown by immunohistochemistry and elevated plasma CT levels. However, the disease history and the clinical features strongly favored a metastasizing GEP-NET. No tumoral RET proto-oncogene mutation was found in this patient. The differential diagnosis between metastatic GEP-NET and MTC is crucial because prognosis, work-up, and treatment differ greatly.  (+info)

Roles of circulating carcinoembryonic antigen and calcitonin in diagnosis of medullary thyroid carcinoma: a comparative study. (5/1409)

Carcinoembryonic antigen (CEA) and calcitonin (CT) were simultaneously determined in sera and tumor tissues from 15 patients with medullary carcinoma of the thyroid (MCT). Serum CEA was increased in all but one patient, and CT did in all of them. Both levels were significantly related to the weight of excised tumor, but not to the presence of metastasis. Furthermore, a significant correlation was noted between the basal levels of CT and CEA. Both levels fell to normal after a radical operation had been performed. Tissue concentrations of CEA and CT in the MCT were more than 100 times those in hyperthyroidism, and the ratios of tissue over serum levels averaged 770 in CEA and 1000 in CT. In the calcium infusion test, CEA levels were not significantly changed in contrast with a distinct increase in CT levels. The results indicate that CEA and CT represent separate activities of the tumor cells, and that circulating CEA together with CT is a useful indicator in the diagnosis and follow-up of the disease.  (+info)

Glucocorticoid-induced secondary osteopenia in female rats: a time course study as compared with ovariectomy-induced osteopenia and response to salmon calcitonin. (6/1409)

Previously we reported that 8-week treatment with methylprednisolone acetate (MPA: 0.1 mg/kg, s.c., 3 days a week) of male rats caused a novel type of osteopenia whose development was prevented by salmon calcitonin (SCT) in a dose-dependent manner. In this study, to compare the MPA-inducible osteopenia with the ovariectomy (OVX)-inducible one, female rats were used instead of male rats and a time-course study of development was made. MPA treatments for 1, 2, 4 and 8 weeks histologically induced characteristic osteopenic changes in a time-dependent manner that were histomorphometrically detectable in tibiae within 4 weeks as reduced bone mass, accelerated bone resorption, and suppressed bone formation and mineralization. Node-strut analysis revealed that the connectivity of the trabecular structure remained unaffected. Such MPA-induced changes in the trabecular structure, to be defined as thinned-but-uncut, is in a good contrast with OVX-induced unthinned-but-cut structure, although the latter osteopenic changes became detectable 2 weeks earlier. Another previous finding confirmed herein was that MPA-induced osteopenia in female rats was also completely masked by SCT (10 U/kg, s.c., 5 days a week). The results indicate that the MPA-inducible secondary osteopenic model in either sex of rats would be usable for testing anti-osteopenic drugs.  (+info)

Protein kinase C antagonizes pertussis-toxin-sensitive coupling of the calcitonin receptor to adenylyl cyclase. (7/1409)

The calcitonin receptor is known to couple to Gs and Gq, activating adenylyl cyclase and phospholipase C, respectively. The observation of pertussis-toxin-sensitive responses to calcitonin suggests that the receptor is capable of coupling to Gi/o as well. However, the calcitonin-dependent activation of adenylyl cyclase in HEK-293 cells that stably express the cloned rabbit calcitonin receptor, as in many other cells that express calcitonin receptors, shows little pertussis toxin sensitivity. Calcitonin treatment of these cells stimulates protein kinase C, which is reported to antagonize the receptor-dependent activation of Gi. The possibility that protein kinase C could be antagonizing Galphai-adenylyl cyclase coupling was tested by examining the effects of protein kinase C inhibitors (chelerythrine chloride and sphingosine) or of chronic treatment with phorbol ester to deplete protein kinase C. All three treatments led to a reduction of calcitonin-induced adenylyl cyclase activity that was reversed by pertussis toxin. Inhibiting or depleting protein kinase C had no effect on the activation of adenylyl cyclase by cholera toxin, indicating that Gs and adenylyl cyclase were not affected by these treatments. Calcitonin treatment of HEK-293 cells, that stably express a myc-tagged rabbit calcitonin receptor, induced the formation of complexes of the receptor and Galphai subunits, confirming that the calcitonin receptor interacts with Gi. Thus, the calcitonin receptor can couple to Gi, but the inhibition of adenylyl cyclase by Galphai is negatively regulated by protein kinase C.  (+info)

A transient increase in renal clearance of phosphate in response to continuous infusion of salmon calcitonin in rats. (8/1409)

The effects of intravenous carrier-free salmon calcitonin on renal clearances of phosphate, calcium, magnesium, sodium and potassium were studied in male parathyroid-ectomized (PTX) and intact rats. Both natural and synthetic hormone, when infused at constant rates (0.005 approximately 0.5 MRC U/hr), produced a rapid increase (peaking at about 60-90 min) in phosphate clearance. However, the maximal increase was transient in nature in PTX rats. In intact rats, the phosphaturic response was somewhat more pronounced and the decline after the peak was rather modest. When a large amount (4 MRC U) of calcitonin was given in divided doses, the second dose produced a lesser extent of phosphaturia in both intact and PTX rats. The phosphaturic response was accompanied by an increase in sodium and potassium clearances in PTX rats and by an increase in potassium clearance in intact rats. A fall in the apparent clearance values for calcium and magnesium occurred and was maintained throughout the infusion period of hormone in both intact and PTX rats. In conclusion, PTX rats respond to the intravenous administration of salmon calcitonin with a transient phosphaturic response which is accompanied by parallel diuresis of sodium and potassium along with sustained retention of calcium and magnesium by the kidney.  (+info)

*Calcitonin

... is secreted into the milk. Calcitonin was extracted from the ultimobranchial glands (thyroid-like glands) of fish, ... Salmon calcitonin resembles human calcitonin, but is more active. At present, it is produced either by recombinant DNA ... In many ways, calcitonin counteracts parathyroid hormone (PTH) and vitamin D More specifically, calcitonin lowers blood Ca2+ ... Salmon calcitonin does not cross the placental barrier. In lactating animals given calcitonin, suppression of milk production ...

*Calcitonin receptor

The calcitonin receptor (CT) is a G protein-coupled receptor that binds the peptide hormone calcitonin and is involved in ... Pondel M (December 2000). "Calcitonin and calcitonin receptors: bone and beyond". International Journal of Experimental ... Nakamura M, Hashimoto T, Nakajima T, Ichii S, Furuyama J, Ishihara Y, Kakudo K (April 1995). "A new type of human calcitonin ... "Calcitonin Receptors: Introduction". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical ...

*Calcitonin gene-related peptide

... (CGRP) is a member of the calcitonin family of peptides, which in humans exists in two forms, α ... The mammalian calcitonin gene-related peptides, adrenomedullin, amylin, and calcitonin receptors". Pharmacol Rev. 54 (2): 233- ... Regulation of the calcitonin gene-related peptide (CGRP) gene is in part controlled by the expression of the mitogen-activated ... 1992). "Calcitonin gene-related peptide in the regulation of cardiac function". Ann NY Acad Sci. 657: 194-203. doi:10.1111/j. ...

*Calcitonin gene-related peptide receptor antagonist

Calcitonin gene-related peptide (CGRP) receptor antagonists are a class of drugs that act as antagonists of the calcitonin gene ... Nakasa, T; Ishikawa, M; Takada, T; Miyaki, S; Ochi, M (2015). "Attenuation of cartilage degeneration by calcitonin gene-related ... Mitsikostas, DD; Reuter, U. "Calcitonin gene-related peptide monoclonal antibodies for migraine prevention: comparisons across ... an Oral Calcitonin Gene Related Peptide Receptor Antagonist". British Journal of Clinical Pharmacology. 79 (5): 831-7. doi: ...

*Osteopenia

... calcitonin; and teriparatide. Studies have shown that the actual benefits of these drugs may be marginal. Approximately 270 ...

*Receptor activity-modifying protein

When associated with the Calcitonin receptor (CTR) or Calcitonin receptor-like (CALCRL) (below), RAMPs can change the ... "Calcitonin Receptors: Introduction". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical ... "Calcitonin Receptors". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. ... Association of RAMPs with either the CT or CALCRL proteins forms 6 different receptors from the calcitonin receptor family: ...

*RAMP1

"Functional calcitonin gene-related peptide receptors are formed by the asymmetric assembly of a calcitonin receptor-like ... "Calcitonin Receptors: Introduction". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical ... "Calcitonin Receptors". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. ... The RAMP1 protein can also interact with the calcitonin receptor (CT) protein, where heteromerisation of RAMP1 with CT converts ...

*Central giant-cell granuloma

... calcitonin (salmon calcitonin); interferon α-2a. These therapeutic approaches provide positive possible alternatives for large ...

*Vertebral compression fracture

"Calcitonin for osteoporotic fractures". Retrieved 2012-09-03. Knopp, Jennifer A.; Diner, Barry M.; Blitz, Maurice; Lyritis, ... For osteoporotic patients, calcitonin may be helpful. Kyphoplasty and vertebroplasty are minimally invasive procedures that ... George P.; Rowe, Brian H. (2004). "Calcitonin for treating acute pain of osteoporotic vertebral compression fractures: A ...

*Failed back syndrome

Hollo I, Gergely I, Boross M (June 1977). "Smoking results in calcitonin resistance". JAMA. 237 (23): 2470. doi:10.1001/jama. ... Nicotine appears to interfere with bone metabolism through induced calcitonin resistance and decreased osteoblastic function. ...

*Parathyroid chief cell

Calcitonin does this by depositing calcium in the bones. PTH works inversely from calcitonin. When the level of calcium in the ... The thyroid gland secretes three hormones: T3, T4, and calcitonin. When the calcium level in the blood is too high, calcitonin ...

*Sclerostin

... production is increased by calcitonin. Thus, osteoblast activity is self regulated by a negative feedback system. ... "Calcitonin impairs the anabolic effect of PTH in young rats and stimulates expression of sclerostin by osteocytes". Bone. 46 (6 ...

*Endocrine gland

Calcitonin, produced by the parafollicular cells of the thyroid gland in response to rising blood calcium levels, depresses ... PTH is the antagonist of calcitonin. PTH release is triggered by falling blood calcium levels and is inhibited by rising blood ...

*Stanniocalcin

Unlike calcitonin, it also regulates phosphate level. It inhibits excretion of phosphate from the kidney. Stanniocalcin was ... By the mid 1970s, it was confirmed that the corpuscles secrete a factor that can reduce calcium level, similar to calcitonin ... Even though other calcium-decreasing hormone, calcitonin, is also present, these fishes require more efficient hormone as ...

*AKTIP

Aiyar N, Rand K, Elshourbagy NA, Zeng Z, Adamou JE, Bergsma DJ, Li Y (Jun 1996). "A cDNA encoding the calcitonin gene-related ... "A human orphan calcitonin receptor-like structure". Biochem Biophys Res Commun. 206 (1): 341-7. doi:10.1006/bbrc.1995.1047. ...

*S100A12

Maayan C, Becker Y, Gesundheit B, Girgis SI (2002). "Calcitonin gene related peptide in familial dysautonomia". Neuropeptides. ...

*Bone metastasis

A Cochrane review of calcitonin for the treatment of metastatic bone pain indicated no benefit in reduction of bone pain, ... Martinez-Zapata, MJ (2012). "Calcitonin used to treat metastatic bone pain". Cochrane Database Syst Rev. doi:10.1002/14651858. ...

*Calcitriol

The effect of calcitonin on renal excretion is disputed.) Calcitriol is produced in the cells of the proximal tubule of the ... Carney SL (1997). "Calcitonin and human renal calcium and electrolyte transport". Miner Electrolyte Metab. 23 (1): 43-7. PMID ... Calcitriol also inhibits the release of calcitonin,[citation needed] a hormone which reduces blood calcium primarily by ...

*Neurotransmission

ACh-calcitonin gene-related peptide (CGRP) co-release. Glutamate-dynorphin co-release (in hippocampus). Noradrenaline and ATP ...

*Samir Mitragotri

... for oral delivery of proteins such as insulin and calcitonin. Prof. Mitragotri has designed and synthesized unique bio-inspired ... "Mucoadhesive intestinal devices for oral delivery of salmon calcitonin". Journal of Controlled Release. 172 (3): 753-762. doi: ...

*Parathyroid gland

Parathyroid hormone and calcitonin (one of the hormones made by the thyroid gland) have key roles in regulating the amount of ... Parathyroid hormone has effects antagonistic to those of calcitonin. Calcium. PTH increases blood calcium levels by directly ...

*Paget's disease of bone

Calcitonin, also called calcitonin-salmon, is a synthetic copy of a polypeptide hormone secreted by the ultimobranchial gland ... Calcitonin is also linked to increased chance of cancer.[citation needed] Due to the increased risk of cancer, the European ... As a solution for injection or infusion, calcitonin should be administered for no more than 4 weeks to prevent acute bone loss ... The agency did not specify a time frame for the short-term use of calcitonin for treating hypercalcemia caused by cancer. ...

*Hans Baruch

This paper was a theoretical one, questioning the physiological importance of the hormone calcitonin. Baruch, H.; Chaikoff, I. ... F.; Baruch, Hans (2003), "Is Calcitonin an Important Physiological substance?", Endocrine, 21 (3), pp. 201-208, doi:10.1385/ ... F.; Baruch, Hans (2003), "Is Calcitonin an Important Physiological substance?", Endocrine, 21 (3), pp. 201-208, doi:10.1385/ ...

*Hypocalcaemia

Agents for the treatment of hypercalcemia, such as Calcitonin. Chronic kidney failure Absent active vitamin D Decreased dietary ...

*SFRS6

Tran Q, Coleman TP, Roesser JR (January 2003). "Human transformer 2beta and SRp55 interact with a calcitonin-specific splice ... Tran Q, Roesser JR (February 2003). "SRp55 is a regulator of calcitonin/CGRP alternative RNA splicing". Biochemistry. 42 (4): ...
Oral calcium supplements (80 mg/kg per 24 h) were given to 23 preterm infants, and the course of serum calcium, magnesium, immunoreactive calcitonin, and gastrin was compared with a control group of 23 matched infants. In the supplemented group, serum calcium concentrations remained at the baseline level (2.31 mmol/l +/- 0.18 SD) while a fall (from 2.27 +/- 0.18 to 1.91 +/- 0.24 mmol/l) was observed at 12-16 hours of age in the control group, with 4 values , 1.75 mmol/l. There was no change in serum magnesium concentration in either group. The postnatal rise of serum immunoreactive calcitonin concentrations in the control group (from 171 +/- 135 to 493 +/- 273 pg/ml at 12-48 hours of age) was not found in the supplemented group. There was a negative correlation between serum calcium and immunoreactive calcitonin levels in the control group, but not in the supplemented group. There was no correlation between serum immunoreactive calcitonin and gastrin concentrations. These data show that oral ...
Results There is no significant difference between two groups, in age, Sex, and symptoms. Serum and CSF procalcitonin, Leukocytosis ,15000, PMN peleocytosis of CSF and also sugarand protein of CSF were significantly higher in bacterial meningitis. Serum and CSF procalcitonin levels in control group were less than 0.5 ng/ml and ,2 ng/ml in bacterial meningitis and only one child (8.33%) in aseptic meningitis (Herpes meningoencephalitis) had serum procalcitonin more than 2 ng/ml same bacterial meningitis.. ...
Background: Anastomotic leaks in colorectal surgery results in a high morbidity and mortality rate. Serum procalcitonin levels is known as a sensitive and specific marker of sepsis and could be use as a marker for early detection of a leak allowing early intervention. It may help a clinician decide to perform a CT scan even earlier especially when the diagnosis of a leak is uncertain. The aim of this study is to determine whether serum procalcitonin is a good predictor of anastomotic leak in colorectal surgery. Methodology: Between July 2014 until October 2015, 70 patients undergoing colorectal surgery were prospectively analyzed in a single-center tertiary teaching hospital. Demographic and surgical data were obtained. Serum procalcitonin was taken before surgery and at day 3 (72 hours) postoperatively. During the postoperative period, the patients were observed in the ward for features of anastomotic leak and if present, it was managed accordingly. The primary outcome was to prospectively ...
Purpose: To correlate ultrasonographic (US) features of medullary thyroid carcinoma (MTC) with pre operative and postoperative calcitonin levels. Materials and Methods: A total of 130 thyroid nodules diagnosed as MTC were evaluated. Two radiologists retrospectively evaluated preoperative US features according to size, shape, margin, echogenicity, type of calcification, and lymph node status. Postoperative clinical and imaging followup (mean duration 31.9 22.5 months) was performed for detection of tumor recurrence. US features, presence of LN metastasis, and tumor recurrence were compared between MTC nodules with and without elevated preoperative calcitonin (|100 pg/mL). Those with normalized and nonnormalized postoperative calcitonin levels groups were also compared. Results: Common US features of MTCs were solid internal content (90.8%), irregular shape (44.6%), circumscribed margin (46.2%), and hypoechogenicity (56.2%). Comparing MTC nodules with and without elevated preoperative calcitonin levels,
Calcitonin is a circulating polypeptide that inhibits bone resorption by inducing both quiescence (Q effect) and retraction (R effect) in osteoclasts. Two structurally related members of the calcitonin gene peptide family, calcitonin gene-related peptide (CGRP) and amylin, inhibit osteoclastic bone resorption selectively via the Q effect. In the present study, we have made measurements of cell spread area in response to the application of amylin, CGRP and a peptide fragment of CGRP, CGRP-(Val8Phe37). We found that, over a wide concentration range (50 pmol/l to 2.5 mumol/l), the selective Q effect agonists did not produce an R effect. Furthermore, the peptides, when used at a 50-fold higher molar concentration than calcitonin, did not antagonize calcitonin-induced cell retraction. Additionally, experiments designed to measure changes in the intracellular free calcium concentration ([Ca2+]i) in single osteoclasts revealed that, unlike calcitonin, the non-calcitonin Q effect agonists did not produce a rise
Peptides , Calcitonin Related Peptides; Calcitonin gene-related peptide (CGRP), adrenomedullin (ADM) and amylin belong to a unique group of calcitonin-related peptide hormones important for homeostasis in diverse tissues. Calcitonin, a 32-amino acid peptide hormone, is essential for calcium balance, whereas CGRP and ADM are important for neurotransmission and cardiovascular and respiratory function. Calcitonin regulates mineral balance by controlling blood concentrations of calcium and phosphorus metabolism and can cause hypercalcemia. An increase in the serum calcium level is known to stimulate calcitonin secretion. In mammals, the major source of calcitonin is from the parafollicular or C cells in the thyroid gland, but it is also synthesized in a wide variety of other tissues, including the lung and intestinal tract. Calcitonin contains a single disulfide bond, which causes the amino terminus to assume the shape of a ring. The calcitonin family of peptides act through G-protein protein coupled
PCT is the prohormone of the hormone calcitonin, but PCT and calcitonin are distinct proteins. Calcitonin is exclusively produced by C-cells of the thyroid gland in response to hormonal stimuli, whereas PCT can be produced by several cell types and many organs in response to proinflammatory stimuli, in particular by bacterial products.1. In healthy people, plasma PCT concentrations are found to be below 0.1 μg/L.2 Depending on the clinical background, a PCT concentration above 0.1 μg/L can indicate clinically relevant bacterial infection, requiring antibiotic treatment.3 PCT levels rise rapidly (within 6 to 12 hours) after a bacterial infectious insult with systemic consequences. The magnitude of the increase in PCT concentration correlates with the severity of the bacterial infection.4 At a PCT concentration ,0.5 μg/L, a patient should be considered at risk of developing severe sepsis or septic shock.5,6 On the other hand, the relief of the septic infection is accompanied by a decrease in ...
Although, glucocorticoid (GC) and calcitonin-induced changes in bone repair have been studied previously, the exact effects of these on fracture healing remain controversial. Hence, the purpose of this experimental study is to determine biochemical and histological effects of locally administrated GC and systemically administrated calcitonin on the kinetics of healing response after bone marrow ablation in rats. After having undergone marrow ablation, a steroid-treated group of rats (n = 24) received a single dose of intramedullary methylprednisolone (2 mg/kg), a calcitonin-treated group (n = 24) received intermittently administrated subcutaneous salmon calcitonin (16 IU/kg), and a control group (n = 24) received intramedullary saline (25 μl). Blood samples taken on days 1, 3, 7, 9, and 15 after ablation showed an increase in serum calcium, alkaline phosphatase (ALP), and phosphate levels in the Calcitonin and Control groups. Levels of calcium and ALP peaked on day 7 after ablation. However, an
Of 80 MEN2A gene carriers (in 61 of whom carrier status was proved by DNA analysis), 66 had abnormal plasma calcitonin values and medullary thyroid carcinoma. Fourteen young carriers had normal results of plasma calcitonin tests. In 8 of these 14, thyroidectomy revealed small foci of medullary thyroid carcinoma; the remaining 6 have not yet been operated on. Of the other 220 family members, 68 were found by DNA analysis not to carry the MEN2A gene. None of these 68 subjects had medullary thyroid carcinoma or pheochromocytoma; 6 had elevated plasma calcitonin concentrations and underwent thyroidectomy but had only C-cell hyperplasia. Conclusions: ...
Summary of Facts and Submissions. I. European patent application No. 82 303 667.8, relating to a human calcitonin precursor polyprotein structural gene, was published with number 0 070 675 with 17 claims. Claims 1 and 7 read as follows:. 1. A structural gene encoding a polypeptide comprising the amino acid sequence of human calcitonin, in which said polypeptide is processable to produce human calcitonin.. 7. A polypeptide containing the amino acid sequence of human calcitonin which is processable to produce human calcitonin.. II. In response to notifications issued by the Examining Division the Applicants (Appellants) filed new sets of claims on different occasions.. Finally, with a letter of 18 May 1988, a set of claims was filed whose Claim 1 reads as follows:. 1. A vector including a structural gene encoding a polypeptide comprising the amino acid sequence of human calcitonin and an additional amino acid at the C-terminus of the amino acid sequence of human calcitonin, wherein the ...
Procalcitonin (PCT) is a peptide precursor of the hormone calcitonin, the latter being involved with calcium homeostasis. It was first identified by Leonard J. Deftos and Bernard A. Roos in the 1970s. It is composed of 116 amino acids and is produced by parafollicular cells (C cells) of the thyroid and by the neuroendocrine cells of the lung and the intestine. The level of procalcitonin in the blood stream of healthy individuals is below the limit of detection (0.01 µg/L) of clinical assays. The level of procalcitonin rises in a response to a proinflammatory stimulus, especially of bacterial origin. It is therefore often classed as an acute phase reactant. In this case, it is produced mainly by the cells of the lung and the intestine.... It does not rise significantly with viral or non-infectious inflammations. With the derangements that a severe infection with an associated systemic response brings, the blood levels of procalcitonin may rise to 100 µg/L. In serum, procalcitonin has a ...
Background and Objective: Vitamin D is known to modulate thyroid neoplastic and autoimmune disease. We investigated the role of the vitamin D receptor (VDR) in normal thyroid development and function (thyrocytes and C cells). Methods: The thyroid phenotype of VDR knockout mice was studied in comparison to wild-type controls. The mice were fed a normal diet or a calcium-rich diet to circumvent effects induced by hypocalcemia. Results: Thyroid morphology was unaltered in VDR knockout mice. Also, expression of different parameters of thyrocyte function was comparable (immunohistochemistry). C cell physiology was, however, affected in the absence of the VDR, resulting in increased thyroidal calcitonin expression (immunohistochemistry), paralleled by increased serum calcitonin levels, but only in normocalcemic mice. To study a possible effect of vitamin D status on basal calcitonin levels in humans, serum calcitonin concentrations were compared between vitamin D-deficient and -sufficient patients ...
Resin peptides useful in the preparation of salmon calcitonin are disclosed along with processes for preparing the same. The invention also embraces peptides from which the resin moiety has been cleaved and which are useful in the synthesis of salmon calcitonin together with processes for preparing the cleaved peptides. In general, the processes involve the solid phase synthesis procedures.
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies. ...
Sigma-Aldrich offers abstracts and full-text articles by [M Feigh, R H Nielsen, C Hansen, K Henriksen, C Christiansen, M A Karsdal].
in Pathologie Biologie (1997), 45(1), 52-6. There appears to be a consensus that 100 IU/day of nasally administered salmon calcitonin may prevent trabecular bone loss during the first years of the menopause. Strong evidence exists that half that ... [more ▼]. There appears to be a consensus that 100 IU/day of nasally administered salmon calcitonin may prevent trabecular bone loss during the first years of the menopause. Strong evidence exists that half that dose may also be sufficient to prevent trabecular bone loss and that higher doses (, or = 200 IU/day) induce a significant increase in spinal bone mineral content. Calcium supplements should be systemically administered when calcitonin is given, particularly at high doses. Rectal calcitonin seems also to be an efficient alternative in prevention of trabecular bone loss. Further studies are required to evaluate the effect of calcitonin in prevention of cortical bone loss. In established osteoporosis, calcitonin may prevent further bone loss ...
The novel inflammatory marker procalcitonin (PCT) was assessed as an index of infection in patients with febrile neutropenia. Blood samples were obtained from 115 patients with febrile neutropenia for determination of PCT levels before onset of fever and daily until the resolution of fever. The median PCT level on the first day of fever was 8.23 ng/mL in patients with bacteremia, compared with 0.86 ng/mL in patients with localized bacterial infections (P = .017). The median PCT level on the first day of fever was 2.62 ng/mL in patients with severe sepsis, compared with 0.57 ng/mL in patients with clinically localized infections (P , .001). A dramatic decrease in PCT levels was documented after resolution of the infection; PCT levels were elevated when the infection worsened. Pronounced PCT levels were also found in patients with fever of unknown origin who were responding to antimicrobial chemotherapy, compared with those not responding to treatment with antibiotics. PCT levels were particularly ...
In HAP, CAP and, to a lesser extent, AECB, but not TB, significantly elevated median PCT levels were found compared to controls. However, median PCT levels in all groups were below the recommended cut-off level of 0.5 ng·mL−1. Therefore, according to the present study, PCT concentration seems not to be particularly useful for the detection of lower respiratory tract infections e.g. CRP. Similar results were obtained by Hedlund and Hansson 21, who compared CRP and PCT levels in CAP in adults. However, Moulin etal. 22 described a superiority of PCT over CRP concentration in paediatric patients with CAP. In the recent publication of Brunkhorst et al. 23, different results, with elevated PCT levels in patients with severe pneumonia, were demonstrated. In contrast to the present study, the latter study included only patients with severe pneumonia, who were treated in the intensive care unit. This could also be a reason for the elevated PCT levels. Although diagnostic value has not been proved, PCT ...
Downlod pdf Article Sharma SK, Kumar A, Yadav B, Singh AK, Pathak R, Hussain M, Sherma A. Role of Serum Procalcitonin in Early Diagnosis of Neonatal Sepsis. National Journal of Medical and Allied Sciences 2015; 4(1):62-66. ...
Definition of Procalcitonin in the Legal Dictionary - by Free online English dictionary and encyclopedia. What is Procalcitonin? Meaning of Procalcitonin as a legal term. What does Procalcitonin mean in law?
FRMC Pharmacy Director, Mike Broyles PharmD, has worked diligently for the past several years, crossing the country, educating Healthcare Representatives about Antibiotic Usage and improving patient outcomes. He recently completed a study in which he included data from over 2100 patients that had been treated at Five Rivers Medical Center. The study consisted of comparing data that was found with the patients who were treated with antibiotics prior to the use of a laboratory test called Procalcitonin (PCT) and those that were treated after the test was available. Procalcitonin (PCT) is a Peptide Precursor of the hormone Calcitonin. The level of Procalcitonin will rise in the presence of a bacterial infection. During the course of antibiotic treatment for these bacterial infections, PCT is measured to verify that the antibiotic administered is decreasing the level of PCT found circulating in the patients bloodstream. If not, Antibiotics might need to be adjusted or changed. As PCT decreases, the ...
Thank you for your interest in spreading the word about Clinical Science.. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.. ...
The purpose of this study is to expose patients with OA to calcitonin and to determine plasma calcitonin levels after administration of 0.6 mg and 0.8 mg oral calcitonin. Also the purpose is to assess the effect of different doses of oral calcitonin (0.6 mg and 0.8 mg oral) compared to placebo on serum CTX-I and CTX-II. Finally to assess the tolerance profile of different doses/formulations of oral calcitonin compared to placebo ...
Looking for Procalcitonin? Find out information about Procalcitonin. A protocol from Microsoft that provides secure transactions over the Web. See security protocol Explanation of Procalcitonin
The dose-dependent disposition, first pass hepatic elimination, and absorption pharmacokinetics (PK) of salmon calcitonin (sCT) were investigated in a canine Intestinal Vascular Access Port (IVAP) model. The PK of sCT were determined after intravenou
Global Salmon Calcitonin Market 2020-2024, Trends and Forecast Report Size and Share Published in 2019-12-26 Available for US$ 2850 at Researchmoz.us
BACKGROUND: In February, 2017, the US Food and Drug Administration approved the blood infection marker procalcitonin for guiding antibiotic therapy in patients with acute respiratory infections. This meta-analysis of patient data from 26 randomised controlled trials was designed to assess safety of procalcitonin-guided treatment in patients with acute respiratory infections from different clinical settings. METHODS: Based on a prespecified Cochrane protocol, we did a systematic literature search on the Cochrane Central Register of Controlled Trials, MEDLINE, and Embase, and pooled individual patient data from trials in which patients with respiratory infections were randomly assigned to receive antibiotics based on procalcitonin concentrations (procalcitonin-guided group) or control ...
BACKGROUND: Procalcitonin is useful for the diagnosis of sepsis but its prognostic value regarding mortality is unclear. This prospective observational study was designed to study the prognostic value of procalcitonin in prediction of 28 day mortality in patients of sepsis. Fifty-four consecutive patients of sepsis, severe sepsis and septic shock defined using the 2001 Consensus Conference SCCM/ESICM/ACCP/ATS/SIS criteria from medical Intensive Care Unit (ICU) of a tertiary care center in New Delhi, India were enrolled from July 2011 to June 2013. Procalcitonin (PCT), C-reactive protein (CRP) measurements were recorded on day 1, day 7 and day 28 of follow up ...
Thermo Fisher Scientific Inc. has received clearance from the U.S. Food and Drug Administration (FDA) that expands the clinical claims of the Thermo Scientific B·R·A·H·M·S PCT (Procalcitonin) biomarker assay for sepsis risk assessment. Clinicians can now use B·R·A·H·M·S PCT to help assess the response of septic patients to treatment by comparing a baseline PCT measurement with a PCT value taken on day four.. B·R·A·H·M·S PCT cleared for assessing mortality risk of septic patients ›. ...
One major advantage of PCT compared to other parameters is its early and highly specific increase in response to bacterial infections and sepsis. Thus, in septic conditions in creased PCT levels can be observed 3-6 hours after infectious challenge.. Low PCT values (,0.25 µg/L) in patients with clinical signs of infection (CAP, UTI) indicate a low probability for blood culture proof of bacterial infection, whereas elevated PCT values (,0.25 µg/L) seem to correlate with the bacterial load and positive blood culture result ...
... ,Calcitonin is synthesized in the parafollicular C-cells of the thyroid gland and is packaged in secretory granules. The major action of calcitonin is to lower plasma calcium concentrations, by inhibiting osteoclast activity, resulting in decreased mobilization of calcium from bone [1]. This effect,medicine,medical supply,medical supplies,medical product
The calcitonin test is primarily used to help diagnose and monitor treatment of C-cell hyperplasia and medullary thyroid cancer. Calcitonin is a hormone produced by special cells in the thyroid called C-cells and excessive amounts are produced in these two rare conditions.
Synonyms for APO-Calcitonin in Free Thesaurus. Antonyms for APO-Calcitonin. 1 synonym for calcitonin: thyrocalcitonin. What are synonyms for APO-Calcitonin?
OBJECTIVES Nonspecific clinical symptoms frequently lead to suspicion of bacterial infection in critically ill children. Clinicians send bacterial cultures for suspected infection and begin an empiric course of antibiotics while microbiology results are pending. We investigated whether the biomarker procalcitonin could be useful to predict confirmed bacterial infection in critically ill children in the PICU, before culture results are available. DESIGN Prospective, blinded single-center study. SETTING Tertiary PICU and cardiothoracic ICU. PATIENTS There were one hundred forty-four patients with suspected bacterial infections that had bacterial cultures sent by clinicians. INTERVENTIONS Procalcitonin samples were obtained at three time intervals: as close to the time of the initial culture as possible (up to 12 hr after) and 24 and 72 hours after the initial culture. Patients were stratified into clinical outcome groups based on microbiology results and clinical symptoms using Centers for Disease
[116 Pages Report] Check for Discount on China Procalcitonin (CAS 56645-65-9) Market by Manufacturers, Regions (Province), Type and Application, Forecast to 2022 report by Global Info Research. Procalcitonin (PCT) is a 116 amino acid residue protein with...
BACKGROUND: The results of recent studies suggest the usefulness of PCT for early diagnosis of neonatal sepsis, with varying results. The aim of this prospective multicenter study was to determine the behavior of serum PCT concentrations in both unin
Calcitonin: Calcitonin, a protein hormone synthesized and secreted in humans and other mammals primarily by parafollicular cells (C cells) in the thyroid gland. In birds, fishes, and
Results Eight completed trials evaluating 1,062 patients with AECOPD met the inclusion criteria. Procalcitonin-based protocols used in all included trials were similar. Antibiotics were recommended for procalcitonin levels ,0.25 μg/L and discouraged for lower levels. All studies were open-labelled or single blinded and the final decision to administer or withhold antibiotic was left to the responsible clinician, who could deviate from the protocol. Adherence to procalcitonin-based protocols ranged between 61.3% and 98.1%. Procalcitonin-based protocols decreased antibiotic prescription (RR 0.56 [0.43, 0.73]) and the total antibiotic exposure (MD −3.83 [−4.32, −3.35]), without affecting clinical outcomes such as rate of treatment failure (RR 0.81 [0.62, 1.06]), length of hospitalisation (MD −0.76 [−1.95, 0.43]), exacerbation recurrence rate (RR 0.96 [0.69, 1.35]) or mortality (RR 0.99 [0.57, 1.70]). However, the quality of the available evidence is low to moderate because of ...
From the authors:. We are grateful to D. Aggarwal and co-workers for their comments on our recent article in the European Respiratory Journal 1. As they indicated, the serum procalcitonin (PCT) level could be altered under various conditions and we agree that clinical manifestations, sputum examination and radiological findings are the gold standard to differentiate pulmonary tuberculosis (PTB) from community-acquired pneumonia. Our data showed that serum PCT is not chronically elevated in PTB patients and that it is a poor prognostic marker when the level is above normal. Therefore, we also consider that serum PCT should be measured in selected cases in terms of its practical cost-benefit performance. ...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Evidence-based recommendations on procalcitonin testing for diagnosing and monitoring sepsis (AVIDA Centaur BRAHMS PCT assay, BRAHMS PCT Sensitive..
Consumer information about the medication CALCITONIN SPRAY - NASAL (Fortical, Miacalcin), includes side effects, drug interactions, recommended dosages, and storage information. Read more about the prescription drug CALCITONIN SPRAY - NASAL.
Calcitonin drug-oligomer conjugates that include a calcitonin drug coupled to an oligomer including a single polyalkylene glycol moiety consisting of between 4 and 10 polyalkylene glycol subunits are disclosed. Pharmaceutical compositions including such conjugates and methods of treating bone disorders by administering such conjugates are also disclosed.
A receptor is defined by the International Union of Pharmacology Committee on Receptor Nomenclature and Drug Classification (NC-IUPHAR) as a protein, or a complex of proteins, which recognizes physiologically relevant ligands that can regulate the protein to mediate cellular events (Ruffolo et al., 2000). This definition does not include associated proteins, which are not required for agonist recognition and/or receptor assembly. Thus, G proteins are not included in the nomenclature of G protein-coupled receptors (GPCRs). Similarly, proteins which modify receptor disposition, such as proteins with a PDZ domain (Sheng and Sala, 2001), and which associate with the cytosolic portion of the receptor are not included. The question arises, however, as to the way to name multimeric receptors where subunits influence receptor assembly and agonist recognition. The essential issue is whether to name the individual proteins or the association of proteins? NC-IUPHAR recommends that, where possible, the ...
BRAHMS AG Receives FDA Clearance to Market Automated Procalcitonin (PCT) Test - read this article along with other careers information, tips and advice on BioSpace
The European Medicines Agency (EMA) is the European equivalent of the US Food and Drug Administration (FDA). On July 19 the EMA announced that it had completed a review of the benefits and risks of calcitonin-containing medicines; it concluded that there was evidence of a small increased risk of cancer with long-term use of these medicines. Calcitonin is a hormone that increases the amount of calcium in the bones and lowers the calcium level in the blood. The EMAs Committee for Medicinal Products for Human Use (CHMP) recommended that they should only be authorized for short-term use for three conditions for which EMA approval had previously been granted: Pagets disease (a chronic bone disease); acute bone loss due to sudden immobilization; and hypercalcemia (high blood level of calcium) caused by cancer. The agency also concluded that the benefits of calcitonin-containing medicines did not outweigh their risks in the treatment of osteoporosis and that they should no longer be used for this ...
Read "High pneumococcal DNA load, procalcitonin and suPAR levels correlate to severe disease development in patients with pneumococcal pneumonia, European Journal of Clinical Microbiology Infectious Diseases" on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
Methods A retrospective study was conducted, 56 patients with SLE were admitted to the intensive care unit (ICU) at a University Hospital in Bogotá, Colombia, between 2008 and 2016. The average age was 40.7 years old (SD ±17.7 y/o), female sex was predominant (71% vs 29%). Correlation between procalcitonin and eosinopenia in patients with positive cultures in bivariate analysis was performed to identify if there was a possible association to include those variables in a logistic regression model to establish an association with positive cultures. ...
Research Report on Europe Procalcitonin Antigen Market Report 2017. The Report includes market price, demand, trends, size, Share, Growth, Forecast, Analysis & Overview.
There are no specific protocols for Recombinant Human Procalcitonin protein (ab53369). Please download our general protocols booklet
The Lancet Infectious Diseases Median consumption of antibiotics was 7.5 daily defined doses (DDD) in the procalcitonin-guided group v 9.3 DDD in the standard-of-care group (absolute difference 2.69, p|0.0001), and median duration of treatment was 5 v 7 days respectively (absolute difference 1.22, p|0.0001).
Calcitonin is used to counteract the effects of excess parathyroid hormone in the body, lowering blood calcium levels to a safe status.
Calcitonin is a hormone which is released by the thyroid and parathyroid glands when the levels of calcium compounds in the blood are too high. The horm...
Calcitonin injection is currently not approved for the treatment of osteoporosis but is sometimes prescribed for people who have fractures of the vertebrae, mainly to relieve pain.. If your doctor recommends an injection, he or she will give you a test dose first to check for an allergic reaction to the medication.. Treatment usually includes injections for three to five days in a row, initially, followed by maintenance therapy three times a week, for up to about six months. Long-term use may decrease the medications effectiveness.. Side- ...
Patient information for CALCITONIN 50 IU/ML SOLUTION FOR INJECTION AND INFUSION Including dosage instructions and possible side effects.
The use of procalcitonin (PCT) testing to guide antibiotic treatment may reduce antibiotic use in patients with sepsis (blood poisoning) or suspected sepsis in the ICU and patients with possible bacterial infections in emergency departments (EDs), accor
BioVendor - BioVendor Research and Diagnostic Products is a developer and manufacturer of immunoassays, recombinant proteins, antibodies and endotoxin-removal products.
We use cookies to enhance your experience on our website. By continuing to use our website, you are agreeing to our use of cookies. You can change your cookie settings at any time.Find out more ...
CALCA - CALCA (untagged)-Human calcitonin-related polypeptide alpha (CALCA), transcript variant 2 available for purchase from OriGene - Your Gene Company.
1998632089, 98632089, DE 69832089 T2, DE 69832089T2, DE-T2-69832089, DE1998632089, DE69832089 T2, DE69832089T2, DE98632089, PCT/1998/3820, PCT/JP/1998/003820, PCT/JP/1998/03820, PCT/JP/98/003820, PCT/JP/98/03820, PCT/JP1998/003820, PCT/JP1998/03820, PCT/JP1998003820, PCT/JP199803820, PCT/JP98/003820, PCT/JP98/03820, PCT/JP98003820, PCT/JP9803820 ...
Procalcitonin antibody [42] (calcitonin-related polypeptide alpha) for ELISA, WB. Anti-Procalcitonin mAb (GTX11494) is tested in Human samples. 100% Ab-Assurance.
40-year-old female underwent thyreoidectomy because of an isolated cold nodule of the thyroid. She had suffered of diarrhea for months. Serum levels of calcitonin and carcino-embryonic-antigen (CEA) were elevated. ...
In 4 weeks I will be finishing an 8 week cycle of oral turanabol 50mg/ED. Since its a mild AAS they say PCT is not required, but im not going to take
I am making this thread since it is a question I answer in PM almost every day on multiple forums. No matter what your PCT is, I highly suggest adding
hey everyone! I am currently on wk #2 of my cycle and it consists of: Weeks 1-14: 600 mg/T400 400 mg/Bold EQ 200 2IUs ed of HGH Jintropin right now i
ok I am going to do a cycle of test e 250 shot twice a week 250 each time. I was told to take nolva and clomid. Where can I get these. Can you order
In comparing the April/May closes for each of the last 33 years(Total Years), Scenario found that the September 30-Year T-Bonds(CBOT) also closed higher in May than April in 14(Cond Years) of those years. Of those 14, USU went on to exceed the May high within the next 2 months in 14 years(Action Years) or 100%(Pct) of the time ...
In comparing the April/May closes for each of the last 34 years(Total Years), Scenario found that the September 30-Year T-Bonds(CBOT) also closed higher in May than April in 15(Cond Years) of those years. Of those 15, USU went on to exceed the May high within the next 2 months in 15 years(Action Years) or 100%(Pct) of the time ...
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Centers RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.. ...
Purpose: Calcitonin receptor gene has also a polymorphism which is associated with bone mass density. This study evaluates the association between calcitonin receptor AluI (rs1801197) and Taq1 calcitonin genes polymorphism with bone density rate. Methods: In this descriptive-analytical study in 2013 in southwestern Iran, 200 blood samples, per the Cochran sample size formula, were taken from women aged 45 and older. DNA was extracted from the samples using the phenol- chloroform method and the genomic fragments in question were proliferated using the polymerase chain reaction (PCR) method. Results: The genotypic distribution of polymorphism AluI for TT, TC, and CC genotypes in control group was 31.4%, 38.6%, and 30% and in patients 25.4%, 55.4%, and 19.2%, respectively. There was no significant difference in polymorphism AluI between patients and control group and no significant association was found between this gene and bone density rate (P , 0.05). All patients and the individuals in the ...
Lysine vasopressin (antidiuretic hormone), like cyclic adenosine 3,5-monophosphate (cyclic AMP), rapidly (in less than 1 hour) stimulates the initiation of deoxyribonucleic acid synthesis and thereby increases the flow of cells into mitosis in rat thymic lymphocyte populations in vitro. This mitogenic action of vasopressin, again like that of cyclic AMP, is potentiated by caffeine, an inhibitor of the intracellular phosphodiesterase which catalyzes the degradation of cyclic AMP. On the other hand, vasopressins mitogenic action (also like that of cyclic AMP) is blocked by imidazole, an activator of cyclic nucleotide phosphodiesterase activity. The hormone, thyrocalcitonin (calcitonin) which is known to block the cyclic AMP-mediated mitogenic effect of parathyroid hormone by interfering with cyclic AMP action, also blocks the mitogenic action of vasopressin. The inhibitory effects of imidazole and thyrocalcitonin on vasopressins mitogenic action are both overcome by the phosphodiesterase inhibitor
Both calcitonin and prostaglandin E2 (PGE2) stimulate adenylate cyclase activity in the human breast cancer cell line (T 47D). The maximum cyclic AMP response to calcitonin exceeds that of PGE2. When maximal concentrations of the two hormones were added simultaneously to the cells, the amount of cyclic AMP generated was less than that seen with calcitonin alone. When cells were treated with the protein toxin of Bordetella pertussis (islet-activating protein; IAP) which inactivates the inhibitory regulatory component (Ni) of adenylate cyclase, there was no change in basal or calcitonin-responsive adenylate cyclase in intact cells. However, the PGE2 response was augmented at all dose levels, and this effect was dependent on the concentration of IAP. Moreover, in cells pretreated with IAP, simultaneous addition of PGE2 and calcitonin resulted in additivity rather than in inhibition of cyclic AMP production. The additivity of the response to calcitonin and PGE2 after IAP treatment implies activation ...
Elcatonin, 0.1 g. |p class=db_paraghraph|Elcatonin is a Calcitonin derivative which is transformed from eels calcitonin by changing the S-S bond into the stable C-N bond.
DROTRECOGIN ALFA [.pdf] Drotrecogin Alfa(Activated) in Severe Sepsis (Report #58) DERMAL MATRIX [.pdf] Evaluation of acellular dermal matrix for breast reconstruction: An Update(Report #59) VIDEO CAPSULE ENDOSCOPY [.pdf] Video capsule endoscopy for obscure GI bleeding and Crohns Disease (Update of Report 7).(Report #60) KTP [.pdf] 532 nm KTP Laser for vocal fold (Report #61) PROCALCITONIN [.pdf] Use of serum procalcitonin levels in treatment decisions for adult patients in the Intensive Care Unit.(Report #62) INTRABEAM [.pdf] Single-dose Intraoperative Radiotherapy Using Intrabeam® for Early-stage Breast cancer: A Health Technology Assessment.(Report #63) TAU IMPACT REPORT [.pdf] The Impact of Reports of The Technology Assessment Unit of the McGill University Health Centre.(Report #65) HYBRID OPERATING ROOM [.pdf] The Hybrid Operating Room. Should one be available for Cardiovascular-Thoracic procedures in the MUHC? A brief report. (Report #67) BALLOON SINUPLASTY [.pdf] Balloon Catheter Dilation for
There has been a growing interest regarding the utility of procalcitonin to guide appropriate initiation and duration of antibiotic therapy in critically ill patients. Two randomized controlled studies in critically ill patients suspected to have bacterial infections arrived at disparate conclusions (De Jong et al. 2016; Bouadma et al. 2010). In patients presenting with…
Background : The mortality on sepsis is still high. Its because of delayed ofthe treatment resulted from the diagnosis of sepsis estabilished more frequently imprecise. The inflammatory makers as c reactive protein and leucocyte apparently have high sensitivity and specifity where do contemn whereas blood culture examination required so long time and the result of culture often negatively. Research on Procalcitonin (PCT) formering have important of the role for the establishment diagnosis of sepsis because its utilized as sepsis marker and in reference to severity sepsisdegree . Objective: To determine whether procalcitonin can be used as sepsis marker and severity of sepsis. Method : Patients were assigned as 2 groups, sepsis and without sepsis with their consisting of 21 samples respectively. In the sepsis subgroup separated as sepsis only (8 samples), severe sepsis (6 samples) and sepsis shock (7 samples). All of them were examined by procalcitonin, C reactive protein, blood culture and ...
Calcitonin (salmon) is a 32-amino acid polypeptide hormone that is produced in humans primarily by the parafollicular cells (also known as C-cells) of the thyroid, and in many other animals in the ultimobranchial body. It acts to reduce blood calcium (Ca2+), opposing the effects of parathyroid hormone (PTH). The calcitonin receptor has been cloned and shown to be a member of the seven-transmembrane, G protein-coupled receptor family.
|h2>|span class=Apple-style-span style=font-weight: normal; font-family: arial; font-size: medium;>|img src=http://upload.wikimedia.org/wikipedia/commons/thumb/3/34/Illu_compact_spongy_bone.jpg/347px-Illu_compact_spongy_bone.jpg alt= align=none>|span class=Apple-style-span style=font-family: Verdana; font-size: 12px; >|img src=http://upload.wikimedia.org/wikipedia/commons/thumb/b/bc/Spongy_bone_-_trabecules.jpg/350px-Spongy_bone_-_trabecules.jpg alt= align=none>|/span>|/span>|/h2>|div>|span class=Apple-style-span style=font-size: x-small;>Picture source: Wikipedia|/span>|/div>|h2>|span class=Apple-style-span style=font-weight: normal; font-family: arial; font-size: medium; >Calcitonin is a polypeptide hormone that participates in calcium and phosphorous metabolism. It controls calcium level in the blood by opposing the effect of the parathyroid hormone through its actions on osteoclasts. Salmon calcitonin is the form of calcitonin used clinically. The two major advantages
IHCPlus™ CALCR / Calcitonin Receptor Antibody LS-A769 is a pathologist validated IHC antibody Rabbit anti-Human CALCR / Calcitonin Receptor. Validated for IHC. Tested on 20 paraffin-embedded human tissues.
Order Calcitonin Receptor ELISA Kits for many Reactivities. Chicken, Guinea Pig, Human and more. Compare Calcitonin Receptor ELISA Kits and find the right product on antibodies-online.com.
Objectives: Higher coronary atherosclerotic burden has been associated with increased cardiovascular events including mortality. The SYNTAX score (SXs) reflects coronary atherosclerotic burden. Given the body of evidence implicating inflammation in atherosclerotic process, we hypothesized that procalcitonin (PCT) as an inflammatory marker may be related to coronary atherosclerotic burden. Thus, we aimed to investigate the relationship between serum PCT levels and SXs in patients with stable CAD. ...
Buy CGRP elisa kit, Fish Calcitonin Gene Related Peptide ELISA Kit-NP_001095943.1 (MBS029789) product datasheet at MyBioSource, ELISA Kits
Severn Biotech, Limited : Calcitonin Gene Related Peptide - Electrophoresis Products PBS & Saline Solutions Hybridisation Reagents Biological Buffers & SDS Sodium Azide Solutions General Bio-chemical Products Fingerprinting Chemical Product Forensic Dyes & Chemicals HPLC Laboratory Solvents DNA / RNA Extraction Specialist Pure Water Products Protein Linker Conjugates Peptide Synthesis Reagents Alcohol Sprays Hand Sanitiser Products Customised Services Comet Assay Products Protein Antibody Reagents Scientific Plastics Catalogue Peptides Affinity Purification Materials Cytology Screening Antibodies Specials severn, biotech
This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin by tissue-specific alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins. Calcitonin is involved in calcium regulation and acts to regulate phosphorus metabolism. Calcitonin gene-related peptide functions as a vasodilator while katacalcin is a calcium-lowering peptide. Multiple transcript variants encoding different isoforms have been found for this gene ...
The thyroid gland is located in the front of the neck. It sits below the voice box (larynx). The small, two-inch gland consists of two lobes, one on each side of the windpipe, connected by a small bridge of thyroid tissue called the isthmus.. The thyroid tissue is made up of two types of cells: follicular cells and parafollicular cells. Most of the thyroid tissue consists of the follicular cells, which secrete the iodine-containing thyroid hormones. They consist of thyroxine (T4) and triiodothyronine (T3). The parafollicular cells secrete the hormone calcitonin. In humans, calcitonin has only a minor role in calcium regulation.. ...
[116 Pages Report] Check for Discount on EMEA (Europe, Middle East and Africa) Procalcitonin (CAS 56645-65-9) Market 2017 Forecast to 2022 report by Global Info Research. Procalcitonin (PCT) is a 116 amino acid residue protein with...
The thyroid gland is located in the front of the neck, below the larynx (voice box). The small, two-inch gland consists of two lobes, one on each side of the windpipe, connected by tissue called the isthmus.. The thyroid tissue is made up of two types of cells: follicular cells and parafollicular cells. Most of the thyroid tissue consists of the follicular cells, which secrete iodine-containing hormones called thyroxine (T4) and triiodothyronine (T3). The parafollicular cells (also called C cells) secrete the hormone calcitonin. The thyroid requires iodine to produce the hormones.. ...
Compared to those with bacterial or mixed infection (n = 9), patients with 2009 H1N1 infection (n = 16) were significantly more likely to have bilateral chest X-ray infiltrates, lower APACHE scores, more prolonged lengths of stay in ICU and lower white cell count, procalcitonin and CRP levels. Using a cutoff of ,0.8 ng/ml, the sensitivity and specificity of procalcitonin for detection of patients with bacterial/mixed infection were 100 and 62%, respectively. A CRP cutoff of ,200 mg/l best identified patients with bacterial/mixed infection (sensitivity 100%, specificity 87.5%). In combination, procalcitonin levels ,0.8 ng/ml and CRP ,200 mg/l had optimal sensitivity (100%), specificity (94%), negative predictive value (100%) and positive predictive value (90%). Receiver-operating characteristic curve analysis suggested the diagnostic accuracy of procalcitonin may be inferior to CRP in this setting.. ...
Calcitonin is supposed to stop the secretion of calcium, but if you have hyperparathyroidism and the body cannot stop pushing out calcium, what happens to the calcitonin? My classmate hypothesized it just is not enough to get rid of all of it, but i dont feel like that is it exactly.
Generic CALCITONIN SALMON RECOMBINANT availability. Has a generic version of CALCITONIN SALMON RECOMBINANT been approved? Find suppliers, manufacturers, and packagers
The aim of this study was to evaluate the procalcitonin (PCT) changes in two different high-dose colistin regimens in the treatment of multi-drug resistant MDR gram negative infections in ICU patients. This is a prospective study of adult ICU patients with bacteremia and ventilator associated pneumonia (VAP) caused by MDR gram negative pathogens. Patients were assigned to two colistin administration groups. Group A received 9 and group B received 3 million international units every 24 and 8 h respectively. Baseline characteristics and measurements of PCT concentrations at the start, the 3rd and the 5th day of the antibiotic therapy and their trends between the two groups were recorded and compared ...
Dear sir: I am urgently need human beta calcitonin gene related peptide gene for my method. Please tell me where to get or buy the gene. Thanks Sincerely Huaichun Wang Institute of Medical Information 27 Taiping Road Beijing 100850 China Fax: 8610 8213044 ...
Results CRP levels of SLE patients with infections were higher than those with flares [5.9 mg/dl (IQR 2.42, 10.53) vs 0.06 mg/dl (IQR 0.03, 0.15), p , 0.001] and decreased after the infection was resolved. S100A8/A9 and procalcitonin levels of SLE patients with infection were also higher [4.69 μg/ml (IQR 2.25, 12.07) vs 1.07 (IQR 0.49, 3.05) (p , 0.001) and 0 ng/ml (IQR 0-0.38) vs 0 (0-0) (p , 0.001), respectively]; these levels were also reduced once the infection disappeared. In the receiver-operating characteristics analysis of CRP, S100A8/A9, and procalcitonin, the area under the curve was 0.966 (95% CI 0.925-1.007), 0.732 (95% CI 0.61-0.854), and 0.667 (95% CI 0.534-0.799), respectively. CRP indicated the presence of an infection with a sensitivity of 100% and a specificity of 90%, with a cutoff value of 1.35 mg/dl. ...
Initially, you are not concerned, maybe even you are pleased a little. However, unexplained weight loss and fatigue are snd of the commonest symptoms you will experience with a progressive illness. There are many possible causes of sudden weight loss and some olss which might be caused due to a serious illness. Here are 10 common conditions that cause unexplained weight loss. Thyroid gland also produces a hormone calcitonin that regulates the level of calcium in your blood. When the fatgiue gland produces too much thyroid hormone overactivethe condition is called hyperthyroidism.. However, not can i lose weight by sleeping a lot has all these symptoms. You may relate to just a few of them. You may fatigus to many of them, too. It mainly affects the lungs. Tuberculosis can also affect the kidneys, spine or brain. The disease can be treated with a six-month course of antibiotics. The airflow can be blocked by an inflammation of the lining of bronchial tubes that wieght air to and from weighf ...
Thank you for your interest in spreading the word about Biochemical Journal.. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.. ...
All patients with medullary thyroid carcinoma (MTC) should undergo calcitonin (CT) determination at regular intervals after total thyroidectomy. Within 6 weeks after operation serum CT measurement...
Results. A total of 1,425 blood cultures were finally enrolled in the study. Of those were considered true bacteremia 179 (12.6 %) and as negative blood cultures 1,246 (87.4 %). Amongst negatives, 1,130 (79.3%) without growth and 116 (8.1%) as contaminants blood cultures. Five variables were significantly associated with true bacteraemia: serum procalcitonin (PCT) ≥ 0.51 ng/ml [odds ratio (OR): 4.52; 95% confidence interval (CI): 4.20-4.84, P ,.001], temperature , 38.3°C [OR:1.60; 95% CI:1.29-1.90, P ,.001], systolic blood pressure (SBP) , 100 mmHg [OR:3.68; 95% CI:2.78-4.58, P ,.001], septic shock [OR:2.96; 95% CI:1.78-4.13, P ,.001] and malignancy [OR:1.73; 95% CI:1.27-2.20, P ,.001 ...
Calcitonin secretion in the pregnant uterus is tightly regulated by the ovarian hormones, estrogen and progesterone, which limit its expression to a brief period preceding blastocyst implantation. The binding of calcitonin to a G protein-coupled receptor activates adenylate cyclase and elevates cytosolic Ca2+ levels. The acceleration of preimplantation embryonic development that is known to occur upon elevation of intracellular Ca2+ prompted an investigation into calcitonin regulation of blastocyst differentiation. Using reverse transcription and the polymerase chain reaction to estimate the relative abundance of calcitonin receptor mRNA, a 25-fold accumulation of the splice variant, CR-1a, was observed in embryos between the 1-cell and 8-cell stages. Cytosolic free Ca2+ levels were rapidly elevated in embryos at the 4-cell to blastocyst stages after exposure to 10 nM calcitonin. Blastocysts treated for 30 minutes with 10 nM calcitonin differentiated in vitro at an accelerated rate, as assessed ...
2017 Laboratory Corporation of America® Holdings and Lexi-Comp Inc. All Rights Reserved.. CPT Statement/Profile Statement. The LOINC® codes are copyright © 1994-2017, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. Additional information regarding LOINC® codes can be found at LOINC.org, including the LOINC Manual, which can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf. ...
TY - JOUR. T1 - The role of procalcitonin for acute pyelonephritis and subsequent renal scarring in infants and young children. AU - Sheu, Ji Nan. AU - Chang, Hung Ming. AU - Chen, Shan Ming. AU - Hung, Tung Wei. AU - Lue, Ko Huang. PY - 2011/11. Y1 - 2011/11. N2 - Purpose: We assessed the usefulness of procalcitonin as a biological marker in diagnosing acute pyelonephritis and for predicting subsequent renal scarring in young children with a first febrile urinary tract infection. Materials and Methods: Children 2 years old or younger with a first febrile urinary tract infection were prospectively studied. Renal parenchymal involvement was assessed by 99mTc-dimercaptosuccinic acid scan within 5 days of admission and after 6 months. Serum samples from all patients were tested for procalcitonin, C-reactive protein and white blood cell count measurements. Results: The 112 enrolled patients (age range 24 days to 24 months old) were divided into acute pyelonephritis (76) and lower urinary tract ...
TY - JOUR. T1 - Cellular Immune Responses in Familial Medullary Thyroid Carcinoma. AU - Rocklin, Ross E.. AU - Gagel, Robert F. AU - Feldman, Zoila. AU - Tashjian, Armen H.. PY - 1977/4/14. Y1 - 1977/4/14. N2 - We studied prospectively 46 members of a kindred with familial medullary thyroid carcinoma to determine the importance of possible cellular immune reactivity to tumor antigen. We evaluated in vitro production of macrophage-migration-inhibitory factor and 3H-thymidine uptake by lymphocytes from patients, family members and normal subjects in response to extracts of medullary thyroid carcinoma and normal thyroid tissue. Lymphocytes from 12 of 18 patients with medullary thyroid carcinoma and four of seven patients with C-cell hyperplasia produced migration inhibitory factor or proliferated (or both) in response to tumor antigen. In contrast, cells from only two of 25 normal subjects and two of nine family members not genetically at risk for medullary thyroid carcinoma made migration ...
article{06e909fb-92e7-430e-8ee0-7c65477569b1, abstract = {,p,The calcitonin receptor (CTR) is relevant to three hormonal systems: amylin, calcitonin, and calcitonin gene-related peptide (CGRP). Receptors for amylin and calcitonin are targets for treating obesity, diabetes, and bone disorders. CGRP receptors represent a target for pain and migraine. Amylin receptors (AMY) are a heterodimer formed by the coexpression of CTR with receptor activity-modifying proteins (RAMPs). CTR with RAMP1 responds potently to both amylin and CGRP. The brain stem is a major site of action for circulating amylin and is a rich site of CGRP binding. This study aimed to enhance our understanding of these hormone systems by mapping CTR expression in the human brain stem, specifically the medulla oblongata. Widespread CTR-like immunoreactivity was observed throughout the medulla. Dense CTR staining was noted in several discrete nuclei, including the nucleus of the solitary tract, the hypoglossal nucleus, the cuneate ...
Medullary thyroid carcinoma comprises less than 10% of all thyroid cancers. This specific type has significant diagnostic importance due to its aggressive nature and close association with multiple endocrine neoplasia syndromes. Approximately 10% to 20% cases affected by medullary thyroid carcinoma are familial. In the majority of cases nodal metastases are present at the moment of diagnosis ...
Medullary thyroid carcinoma (MTC) is a malignant neoplasm derived from parafollicular C-cells. MTC comprises approximately 3-10% of thyroid carcinomas and can occur in sporadic (75-80% of cases) or heritable forms (multiple endocrine neoplasia [MEN] 2a, MEN 2b and familial medullary thyroid carcinoma [FMTC]). Patients with sporadic MTC and FMTC present at the age of 44-50 years and usually have a solitary thyroid nodule. These patients can have paraneoplastic syndromes such as diarrhea and Cushings syndrome. The patients with MEN 2a and MEN 2b are younger and often have bilateral, multiple tumor nodules that are associated C-cell hyperplasia. The hereditary forms of MTC are caused by germline mutations of the RET proto-oncogene. MTC is an indolent but aggressive tumor that spreads via hematogenous and lymphatic routes. Up to 50% of patients have cervical nodal metastasis at the presentation. The classic cytomorphologic features of MTC include single and discohesive clusters of intermediate ...
TY - JOUR. T1 - Prevention of stress- or nitric oxide donor-induced medication overuse headache by a calcitonin gene-related peptide antibody in rodents. AU - Kopruszinski, Caroline Machado. AU - Xie, Jennifer Yanhua. AU - Eyde, Nathan Mackenzie. AU - Remeniuk, Bethany. AU - Walter, Sarah. AU - Stratton, Jennifer. AU - Bigal, Marcelo. AU - Chichorro, Juliana Geremias. AU - Dodick, David. AU - Porreca, Frank. PY - 2017/5/1. Y1 - 2017/5/1. N2 - Objective The objective of this study was the determination of the role of calcitonin gene-related peptide (CGRP) in the induction of medication overuse headache (MOH)-related migraine in an injury-free preclinical model. Methods Rats were primed by a 7-day period of exposure to acute migraine therapies including sumatriptan and morphine. After an additional 14-day drug-free period, rats were exposed to putative migraine triggers including bright light stress (BLS) or nitric oxide (NO) donor in the presence or absence of TEV48125, a fully humanized CGRP ...

Expression of calcitonin receptor-like receptor in human vascular tumours | Journal of Clinical PathologyExpression of calcitonin receptor-like receptor in human vascular tumours | Journal of Clinical Pathology

Adrenomedullin, a potent vasodilative peptide, and its receptor, calcitonin receptor-like receptor (CRLR), play an important ...
more infohttp://jcp.bmj.com/content/59/10/1104

Calcitonin receptor-like receptor activity modifying protein 3 | definition of calcitonin receptor-like receptor activity...Calcitonin receptor-like receptor activity modifying protein 3 | definition of calcitonin receptor-like receptor activity...

What is calcitonin receptor-like receptor activity modifying protein 3? Meaning of calcitonin receptor-like receptor activity ... What does calcitonin receptor-like receptor activity modifying protein 3 mean? ... calcitonin receptor-like receptor activity modifying protein 3 explanation free. ... Looking for online definition of calcitonin receptor-like receptor activity modifying protein 3 in the Medical Dictionary? ...
more infohttps://medical-dictionary.thefreedictionary.com/calcitonin+receptor-like+receptor+activity+modifying+protein+3

Effect of early oral calcium supplementation on serum calcium and immunoreactive calcitonin concentration in preterm infants. |...Effect of early oral calcium supplementation on serum calcium and immunoreactive calcitonin concentration in preterm infants. |...

There was a negative correlation between serum calcium and immunoreactive calcitonin levels in the control group, but not in ... The postnatal rise of serum immunoreactive calcitonin concentrations in the control group (from 171 +/- 135 to 493 +/- 273 pg/ ... There was no correlation between serum immunoreactive calcitonin and gastrin concentrations. These data show that oral calcium ... Effect of early oral calcium supplementation on serum calcium and immunoreactive calcitonin concentration in preterm infants. ...
more infohttp://adc.bmj.com/content/55/8/611

Calcitonin gene-related peptide in experimental ischemia. Implication of an endogenous anti-ischemic effect<...Calcitonin gene-related peptide in experimental ischemia. Implication of an endogenous anti-ischemic effect<...

Calcitonin gene-related peptide in experimental ischemia. Implication of an endogenous anti-ischemic effect. Annals of Plastic ... Calcitonin gene-related peptide in experimental ischemia. Implication of an endogenous anti-ischemic effect. In: Annals of ... Calcitonin gene-related peptide (CGRP), a neuropeptide, is a naturally occurring vasodilator with no constrictive effects. In ... Calcitonin gene-related peptide in experimental ischemia. Implication of an endogenous anti-ischemic effect. / Gherardini, ...
more infohttps://jhu.pure.elsevier.com/en/publications/calcitonin-gene-related-peptide-in-experimental-ischemia-implicat-3

Calcitonin gene-related peptide enhances release of native brain-derived neurotrophic factor from trigeminal ganglion neurons<...Calcitonin gene-related peptide enhances release of native brain-derived neurotrophic factor from trigeminal ganglion neurons<...

Buldyrev, I., Tanner, N. M., Hsieh, H. Y., Dodd, E. G., Nguyen, L. T., & Balkowiec, A. (2006). Calcitonin gene-related peptide ... Calcitonin gene-related peptide enhances release of native brain-derived neurotrophic factor from trigeminal ganglion neurons. ... Calcitonin gene-related peptide (CGRP), which is expressed by trigeminal nociceptors, has recently been identified as a key ... Calcitonin gene-related peptide (CGRP), which is expressed by trigeminal nociceptors, has recently been identified as a key ...
more infohttps://ohsu.pure.elsevier.com/en/publications/calcitonin-gene-related-peptide-enhances-release-of-native-brain--2

Cellular Immune Responses in Familial Medullary Thyroid Carcinoma<...Cellular Immune Responses in Familial Medullary Thyroid Carcinoma<...

1 2 Its detection has been greatly facilitated by the measurement of plasma calcitonin concentrations, which are increased in ... inherited as an autosomal dominant trait.1 2 Its detection has been greatly facilitated by the measurement of plasma calcitonin ... inherited as an autosomal dominant trait.1 2 Its detection has been greatly facilitated by the measurement of plasma calcitonin ... inherited as an autosomal dominant trait.1 2 Its detection has been greatly facilitated by the measurement of plasma calcitonin ...
more infohttps://mdanderson.elsevierpure.com/en/publications/cellular-immune-responses-in-familial-medullary-thyroid-carcinoma

Plasma adrenomedullin as an indicator of prognosis after acute myocardial infarction | HeartPlasma adrenomedullin as an indicator of prognosis after acute myocardial infarction | Heart

... sharing slight homology with calcitonin gene related peptide and amylin. Immunoreactive adrenomedullin has been detected in ...
more infohttp://heart.bmj.com/content/81/5/483

Calcitonin | hormone | Britannica.comCalcitonin | hormone | Britannica.com

Calcitonin, a protein hormone synthesized and secreted in humans and other mammals primarily by parafollicular cells (C cells) ... Both increased calcitonin secretion and increased calcitonin activity are relatively short-lived, lasting only a few days. As a ... thyroid gland: The thyroid gland and calcitonin. …adults. The thyroid gland is also the site of the production of calcitonin, a ... hormone: Ultimobranchial tissue and calcitonin. …enzyme synthesis. The discovery of calcitonin (thyrocalcitonin) in 1961 ...
more infohttps://www.britannica.com/science/calcitonin-hormone

calcitonin - Everything2.comcalcitonin - Everything2.com

Calcitonin is a hormone which is released by the thyroid and parathyroid glands when the levels of calcium compounds in the ... Calcitonin is a hormone which is released by the thyroid and parathyroid glands when the levels of calcium compounds in the ... A calcitonin molecule is a small peptide composed of thirty-two amino acids. ...
more infohttps://everything2.com/title/calcitonin

Calcitonin, SerumCalcitonin, Serum

Patient Preparation: 12 hours before this blood test do not take multivitamins or dietary supplements containing biotin or vitamin B7, which are commonly found in hair, skin, and nail supplements and multivitamins.. Collection Instructions: After draw immediately place specimen on ice and transport to the lab within 30 minutes.. ...
more infohttps://www.nationwidechildrens.org/specialties/laboratory-services/lab-test-directory/calcitonin-serum

Miacalcic injection (calcitonin salmon)Miacalcic injection (calcitonin salmon)

... which is a synthetic form of the natural hormone calcitonin. ... This action of calcitonin gives it a number of uses. For ... Miacalcic injection contains the active ingredient salmon calcitonin (previously known as salcatonin in the UK), ... Miacalcic injection (calcitonin salmon). Miacalcic injection contains the active ingredient salmon calcitonin (previously known ... Calcitonin prevents the movement of calcium from the bones into the blood and so can be used to lower high levels of calcium in ...
more infohttps://www.netdoctor.co.uk/medicines/aches-pains/a6253/miacalcic-injection-calcitonin-salmon/

Calcitonin IRMA TestCalcitonin IRMA Test

The major action of calcitonin is to lower plasma calcium concentrations, by inhibiting osteoclast activity, resulting in ... Calcitonin is synthesized in the parafollicular C-cells of the thyroid gland and is packaged in secretory granules. ... Calcitonin RIA Kit. 3. Nichols Advantage® Calcitonin Assay. 4. Calcitonin RIA Test. 5. Calcitonin, Ultra-Sensitive RIA Test. 6 ... Calcitonin Assay Immunoradiometric (IRMA) Assay. 7. Calcitonin Microwell-EIA. 8. Calcitonin ELISA. 9. Calcitonin. ...
more infohttp://www.bio-medicine.org/medicine-products/Calcitonin-IRMA-Test-18510-1/

Calcitonin blood test: MedlinePlus Medical EncyclopediaCalcitonin blood test: MedlinePlus Medical Encyclopedia

The calcitonin blood test measures the level of the hormone calcitonin in the blood. ... The calcitonin blood test measures the level of the hormone calcitonin in the blood. ... Calcitonin helps control the breakdown and rebuilding of bone.. A common reason to have the test is if you have had surgery to ... Calcitonin is a hormone produced in C cells of the thyroid gland. The thyroid gland is located inside the front of your lower ...
more infohttps://medlineplus.gov/ency/article/003699.htm

Calcitonin Salmon Injection: MedlinePlus Drug InformationCalcitonin Salmon Injection: MedlinePlus Drug Information

Calcitonin Salmon Injection: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Continue to use calcitonin salmon even if you feel well. Do not stop using calcitonin salmon without talking to your doctor. ... Before using calcitonin salmon injection,. *tell your doctor and pharmacist if you are allergic to calcitonin salmon or any ... Use calcitonin salmon injection exactly as directed. Do not use more or less of it or use it more often than prescribed by your ...
more infohttps://medlineplus.gov/druginfo/meds/a682788.html

Calcitonin - WikipediaCalcitonin - Wikipedia

Calcitonin is secreted into the milk. Calcitonin was extracted from the ultimobranchial glands (thyroid-like glands) of fish, ... Salmon calcitonin resembles human calcitonin, but is more active. At present, it is produced either by recombinant DNA ... In many ways, calcitonin counteracts parathyroid hormone (PTH) and vitamin D More specifically, calcitonin lowers blood Ca2+ ... Salmon calcitonin does not cross the placental barrier. In lactating animals given calcitonin, suppression of milk production ...
more infohttps://en.wikipedia.org/wiki/Calcitonin

calcitonin (thing) by BioTech - Everything2.comcalcitonin (thing) by BioTech - Everything2.com

Calcitonin is a hormone which is released by the thyroid and parathyroid glands when the levels of calcium compounds in the ... calcitonin (thing). See all of calcitonin, no other writeups in this node. ... Calcitonin is a hormone which is released by the thyroid and parathyroid glands when the levels of calcium compounds in the ... A calcitonin molecule is a small peptide composed of thirty-two amino acids. ...
more infohttps://everything2.com/user/BioTech/writeups/calcitonin

Womens Health Matters - CalcitoninWomen's Health Matters - Calcitonin

Calcitonin. Calcitonin is a hormone that occurs naturally in your body. It is secreted by the thyroid gland, and helps regulate ... Calcitonin nasal spray. Calcitonin nasal spray, available in Canada as Miacalcin®, is approved for the treatment of ... If you are pregnant or breastfeeding, you should not use calcitonin.. Cost. Coverage of calcitonin varies from province to ... Calcitonin injection. Calcitonin injection is currently not approved for the treatment of osteoporosis but is sometimes ...
more infohttp://www.womenshealthmatters.ca/health-centres/bone-joint-health/treatment/calcitonin/

What is Calcitonin? - calculatorWhat is Calcitonin? - calculator

Calcitonin can slow bone loss in the spine and increase spine bone density. Calcitonin may also help reduce the risk of spine ... Calcitonin has not been shown to prevent bone loss or fracture in other parts of the body and is given as a nasal spray or as ... What are the side effects of calcitonin?. Side effects may include a runny nose with the nasal spray or an allergic reaction or ... Calcitonin is a hormone found in the human body that helps with bone metabolism and calcium regulation. ...
more infohttps://americanbonehealth.org/medications-bone-health/what-is-calcitonin/

Calcitonin, Ultra-Sensitive RIA TestCalcitonin, Ultra-Sensitive RIA Test

The major action of calcitonin is to lower plasma calcium concentrations, by inhibiting osteoclast activity, resulting in ... Calcitonin is synthesized in the parafollicular C-cells of the thyroid gland and is packaged in secretory granules. ... Elevated serum calcitonin levels may also occur in a variety of other malignancies, possibly due to ectopic calcitonin ... following exogenous administration of calcitonin. Exogenously administered calcitonin has also been shown to reduce pain ...
more infohttp://www.bio-medicine.org/medicine-products/Calcitonin--Ultra-Sensitive-RIA-Test-11850-1/

Calcitonin receptor - WikipediaCalcitonin receptor - Wikipedia

The calcitonin receptor (CT) is a G protein-coupled receptor that binds the peptide hormone calcitonin and is involved in ... Pondel M (December 2000). "Calcitonin and calcitonin receptors: bone and beyond". International Journal of Experimental ... Nakamura M, Hashimoto T, Nakajima T, Ichii S, Furuyama J, Ishihara Y, Kakudo K (April 1995). "A new type of human calcitonin ... "Calcitonin Receptors: Introduction". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical ...
more infohttps://en.wikipedia.org/wiki/Calcitonin_receptor

Calcitonin: Reference Range, Interpretation, Collection and PanelsCalcitonin: Reference Range, Interpretation, Collection and Panels

encoded search term (Calcitonin) and Calcitonin What to Read Next on Medscape. Related Conditions and Diseases. * ... In addition to calcitonin testing being very useful for patients with MTC/familial MTC, calcitonin levels are reported to be ... Measurement of calcitonin. Calcitonin is assessed in clinical laboratories using noncompetitive immunoassays of different ... The specificity of calcitonin testing increases with provocative testing. Pentagastrin stimulation before a calcitonin assay ...
more infohttps://emedicine.medscape.com/article/2087580-overview?pa=cbm5fa4HmQI3BHnWHxPacO6fvIEY9S%2Fu%2F2lOF5Q0WI0txMrOV8GxGuli%2B%2F%2FLmmmX2jVVQl51J59IFgAn4RbHnywhCTQq25Ki1mL6i64Z7Vg%3D

calcitonin gene-related peptide | Modern medicinecalcitonin gene-related peptide | Modern medicine

Home , About us , Contact us , Advertise , All Content , Editorial and Advertising Policy , Terms and Conditions , Privacy Policy , Terms of Use , Advertiser Terms , Linking and RSS policy. © 2018 UBM Medica, LLC, a UBM company. Reproduction in whole or in part is prohibited.. Please send any technical comments or questions to our webmaster.. ...
more infohttp://www.modernmedicine.com/tag/calcitonin-gene-related-peptide

026781: Calcitonin (Thyrocalcitonin), Three Specimens | LabCorp026781: Calcitonin (Thyrocalcitonin), Three Specimens | LabCorp

Calcitonin, Serum (3 Spec). 019859. Tube ID #3. N/A. 026781. Calcitonin, Serum (3 Spec). 026793. Calcitonin (3 Specimens). N/A ... Calcitonin, Serum (3 Spec). 019848. Calcitonin #1. pg/mL. 58892-1. 026781. Calcitonin, Serum (3 Spec). 019857. Tube ID #1. N/A ... Calcitonin, Serum (3 Spec). 019851. Calcitonin #2. pg/mL. 33788-1. 026781. Calcitonin, Serum (3 Spec). 019858. Tube ID #2. N/A ...
more infohttps://www.labcorp.com/test-menu/21591/calcitonin-thyrocalcitonin-three-specimens

048249: Calcitonin (Thyrocalcitonin), Two Specimens | LabCorp048249: Calcitonin (Thyrocalcitonin), Two Specimens | LabCorp

Calcitonin, Serum (2 Spec). 019858. Tube ID #2. N/A. 048249. Calcitonin, Serum (2 Spec). 048262. Calcitonin (2 Specimens). N/A ... Calcitonin, Serum (2 Spec). 019848. Calcitonin #1. pg/mL. 58892-1. 048249. Calcitonin, Serum (2 Spec). 019857. Tube ID #1. N/A ...
more infohttps://www.labcorp.com/test-menu/21586/calcitonin-thyrocalcitonin-two-specimens
  • A gene on chromosome 7p13-p12 that encodes one of the RAMP (receptor [calcitonin] activity modifying protein) family of single-transmembrane-domain proteins, which are type-I transmembrane proteins needed to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. (thefreedictionary.com)
  • Synthetic analogues of calcitonin are of particular interest in the treatment of osteoporosis , a disease characterized by the thinning of bones that arises from increased bone resorption or decreased bone formation . (britannica.com)
  • Long-term use of calcitonin is associated with an increased risk of various types of cancers and it should no longer be used in the long-term treatment of osteoporosis. (netdoctor.co.uk)
  • Calcitonin injection is currently not approved for the treatment of osteoporosis but is sometimes prescribed for people who have fractures of the vertebrae, mainly to relieve pain. (womenshealthmatters.ca)
  • Calcitonin sometimes is used as treatment to relieve pain from spinal fractures related to osteoporosis. (peacehealth.org)
  • Calcitonin is reserved for the treatment of postmenopausal osteoporosis in women when other treatments for osteoporosis are ineffective, not tolerated, or not desired. (drugs.com)
  • In addition to banning its use for osteoporosis, the CHMP recommended that calcitonin should be administered for no more than four weeks to prevent acute bone loss resulting from sudden immobilization, and normally for no more than three months to treat Paget's disease. (emaxhealth.com)
  • Calcitonin may be useful in treating various bone disorders including, but not limited to, osteoporosis and Paget's disease. (google.co.uk)
  • In humans, the calcitonin protein is made up of 32 amino acids . (britannica.com)
  • A calcitonin molecule is a small peptide composed of thirty-two amino acid s. (everything2.com)
  • Precalcitonin (116 amino acids) is cleaved to procalcitonin, which is further cleaved to immature calcitonin (33 amino acids) and then to mature calcitonin, a monomer of a 3.5-kd peptide composed of 32 amino acids, which is the only biologically active form. (medscape.com)
  • Calcitonin contains a single disulfide bond, which causes the amino terminus to assume the shape of a ring. (anaspec.com)
  • This invention relates to the hormone calcitonin and DESCRIPTION OF INVENTION to substances having biological activity similar to calci- In general we use a solid phase type of synthesis and tonin and to substances which may be converted into start with a resin called benzhydryl amine resin (Bl-1A such biologically active substances. (google.com)
  • Hypocalcemia must be corrected before starting calcitonin, and blood calcium levels monitored throughout treatment. (drugs.com)
  • The assays are heterogeneous, with different sensitivity and specificity, and often they recognize multiple forms of immunoreactive calcitonin. (medscape.com)
  • After curative surgery for MTC, serum calcitonin levels fall to undetectable levels over several weeks. (medscape.com)
  • If previously undetectable or very low postoperative serum calcitonin levels are found to have increased, disease recurrence or spread is highly likely and further diagnostic evaluation is warranted. (medscape.com)
  • It is also a short-lived effect because the kidneys become resistant to calcitonin, as demonstrated by the kidney's unaffected excretion of calcium in patients with thyroid tumors that secrete excessive calcitonin. (wikipedia.org)
  • Calcitonin injection can be given for short periods of time to prevent further bone loss in people who have suddenly become immobile. (netdoctor.co.uk)
  • The investigators found that "a higher proportion of patients treated with calcitonin for long periods of time develop cancer of various types, compared with patients taking placebo. (emaxhealth.com)
  • The EMA study included a review of available data from the companies that market these drugs, postmarketing safety data, randomized controlled studies, two studies of unlicensed oral calcitonin drugs, and experimental cancer studies. (emaxhealth.com)
  • Calcitonin is derived from larger precursors. (medscape.com)
  • The present invention relates to drug-oligomer conjugates, and, more particularly, to calcitonin drug-oligomer conjugates. (google.co.uk)
  • Other potent calcitonin secretagogues include the gastrointestinal peptide hormones, gastrin in particular. (medscape.com)
  • Amylin is a member of the calcitonin family of hormones cosecreted with insulin by pancreatic beta cells. (semanticscholar.org)