AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and Occupations
CalcitoninCalcitonin Gene-Related PeptideReceptors, CalcitoninReceptors, Calcitonin Gene-Related PeptideCalcitonin Receptor-Like ProteinReceptor Activity-Modifying ProteinsReceptor Activity-Modifying Protein 1AdrenomedullinSalmonReceptor Activity-Modifying Protein 2Receptor Activity-Modifying Protein 3Receptors, Islet Amyloid PolypeptideSubstance PReceptors, AdrenomedullinCarcinoma, MedullaryCapsaicinThyroid NeoplasmsNeuropeptidesUltimobranchial BodyEelsOsteitis DeformansThyroidectomyParathyroid HormonePentagastrinCyclic AMPMioticsThyroid GlandReceptors, PeptideIslet Amyloid PolypeptideRats, Sprague-DawleyBone ResorptionNeurons, AfferentRadioimmunoassayTrigeminal GanglionCalciumHypocalcemiaOsteoclastsVasoactive Intestinal PeptideGanglia, SpinalCalcium GluconatePeptide FragmentsNerve FibersBone Density Conservation AgentsDose-Response Relationship, DrugTrigeminal NerveNeurokinin ARNA, MessengerHydroxyprolinePeptidesRats, WistarNeuropeptide YHypercalcemiaVasodilationBone and BonesImmunohistochemistryMigraine DisordersHormones, Ectopic
Calcitonin
A peptide hormone that lowers calcium concentration in the blood. In humans, it is released by thyroid cells and acts to decrease the formation and absorptive activity of osteoclasts. Its role in regulating plasma calcium is much greater in children and in certain diseases than in normal adults.
Calcitonin Gene-Related Peptide
Calcitonin gene-related peptide. A 37-amino acid peptide derived from the calcitonin gene. It occurs as a result of alternative processing of mRNA from the calcitonin gene. The neuropeptide is widely distributed in neural tissue of the brain, gut, perivascular nerves, and other tissue. The peptide produces multiple biological effects and has both circulatory and neurotransmitter modes of action. In particular, it is a potent endogenous vasodilator.
Receptors, Calcitonin
Cell surface proteins that bind calcitonin and trigger intracellular changes which influence the behavior of cells. Calcitonin receptors outside the nervous system mediate the role of calcitonin in calcium homeostasis. The role of calcitonin receptors in the brain is not well understood.
Receptors, Calcitonin Gene-Related Peptide
Cell surface proteins that bind CALCITONIN GENE-RELATED PEPTIDE with high affinity and trigger intracellular changes which influence the behavior of cells. CGRP receptors are present in both the CENTRAL NERVOUS SYSTEM and the periphery. They are formed via the heterodimerization of the CALCITONIN RECEPTOR-LIKE PROTEIN and RECEPTOR ACTIVITY-MODIFYING PROTEIN 1.
Calcitonin Receptor-Like Protein
A receptor protein that is associated with RECEPTOR ACTIVITY-MODIFYING PROTEINS. When bound to RECEPTOR ACTIVITY-MODIFYING PROTEIN 1 it forms the CALCITONIN GENE-RELATED RECEPTOR. When bound to RECEPTOR ACTIVITY-MODIFYING PROTEIN 2 or RECEPTOR ACTIVITY-MODIFYING PROTEIN 3 it forms the ADRENOMEDULLIN RECEPTOR.
Receptor Activity-Modifying Proteins
A family of proteins that bind to CELL SURFACE RECEPTORS and alter their specificity, signaling mechanism, or mode of intracellular transport.
Receptor Activity-Modifying Protein 1
A receptor activity-modifying protein that is a subunit of specific G-PROTEIN COUPLED RECEPTORS. The CALCITONIN GENE-RELATED PEPTIDE RECEPTOR is formed from a dimer of this protein and CALCITONIN RECEPTOR-LIKE PROTEIN, while an isoform of the ISLET AMYLOID POLYPEPTIDE RECEPTOR is formed from this protein dimerizing with the CALCITONIN RECEPTOR.
Adrenomedullin
A 52-amino acid peptide with multi-functions. It was originally isolated from PHEOCHROMOCYTOMA and ADRENAL MEDULLA but is widely distributed throughout the body including lung and kidney tissues. Besides controlling fluid-electrolyte homeostasis, adrenomedullin is a potent vasodilator and can inhibit pituitary ACTH secretion.
Salmon
Fish of the genera ONCORHYNCHUS and Salmo in the family SALMONIDAE. They are anadromous game fish, frequenting the coastal waters of both the North Atlantic and Pacific. They are known for their gameness as a sport fish and for the quality of their flesh as a table fish. (Webster, 3d ed).
Receptor Activity-Modifying Protein 2
A receptor activity-modifying protein that heterodimerizes with CALCITONIN RECEPTOR-LIKE PROTEIN to form the ADRENOMEDULLIN RECEPTOR. In addition, an isoform of the ISLET AMYLOID POLYPEPTIDE RECEPTOR is formed from this protein dimerizing with the CALCITONIN RECEPTOR.
Receptor Activity-Modifying Protein 3
A receptor activity-modifying protein that heterodimerizes with CALCITONIN RECEPTOR-LIKE PROTEIN to form the ADRENOMEDULLIN RECEPTOR. In addition, an isoform of the ISLET AMYLOID POLYPEPTIDE RECEPTOR is formed from this protein dimerizing with the CALCITONIN RECEPTOR.
Receptors, Islet Amyloid Polypeptide
G-protein coupled receptors that are formed through the dimerization of the CALCITONIN RECEPTOR with a RECEPTOR ACTIVITY-MODIFYING PROTEIN. Their affinity for ISLET AMYLOID POLYPEPTIDE is dependent upon which of several receptor activity-modifying protein subtypes they are bound to.
Substance P
An eleven-amino acid neurotransmitter that appears in both the central and peripheral nervous systems. It is involved in transmission of PAIN, causes rapid contractions of the gastrointestinal smooth muscle, and modulates inflammatory and immune responses.
Receptors, Adrenomedullin
G-protein-coupled cell surface receptors for ADRENOMEDULLIN. They are formed by the heterodimerization of CALCITONIN RECEPTOR-LIKE PROTEIN and either RECEPTOR ACTIVITY-MODIFYING PROTEIN 2 or RECEPTOR ACTIVITY-MODIFYING PROTEIN 3.
Carcinoma, Medullary
A carcinoma composed mainly of epithelial elements with little or no stroma. Medullary carcinomas of the breast constitute 5%-7% of all mammary carcinomas; medullary carcinomas of the thyroid comprise 3%-10% of all thyroid malignancies. (From Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1141; Segen, Dictionary of Modern Medicine, 1992)
Capsaicin
An alkylamide found in CAPSICUM that acts at TRPV CATION CHANNELS.
Thyroid Neoplasms
Tumors or cancer of the THYROID GLAND.
Neuropeptides
Peptides released by NEURONS as intercellular messengers. Many neuropeptides are also hormones released by non-neuronal cells.
Ultimobranchial Body
A diverticulum from the fourth pharyngeal pouch of an embryo, regarded by some as a rudimentary fifth pharyngeal pouch and by others as a lateral thyroid primordium. The ultimobranchial bodies of lower vertebrates contain large amounts of calcitonin. In mammals the bodies fuse with the thyroid gland and are thought to develop into the parafollicular cells. (Stedman, 25th ed)
Eels
Common name for an order (Anguilliformes) of voracious, elongate, snakelike teleost fishes.
Osteitis Deformans
A disease marked by repeated episodes of increased bone resorption followed by excessive attempts at repair, resulting in weakened, deformed bones of increased mass. The resultant architecture of the bone assumes a mosaic pattern in which the fibers take on a haphazard pattern instead of the normal parallel symmetry.
Thyroidectomy
Surgical removal of the thyroid gland. (Dorland, 28th ed)
Parathyroid Hormone
A polypeptide hormone (84 amino acid residues) secreted by the PARATHYROID GLANDS which performs the essential role of maintaining intracellular CALCIUM levels in the body. Parathyroid hormone increases intracellular calcium by promoting the release of CALCIUM from BONE, increases the intestinal absorption of calcium, increases the renal tubular reabsorption of calcium, and increases the renal excretion of phosphates.
Pentagastrin
A synthetic pentapeptide that has effects like gastrin when given parenterally. It stimulates the secretion of gastric acid, pepsin, and intrinsic factor, and has been used as a diagnostic aid.
Cyclic AMP
An adenine nucleotide containing one phosphate group which is esterified to both the 3'- and 5'-positions of the sugar moiety. It is a second messenger and a key intracellular regulator, functioning as a mediator of activity for a number of hormones, including epinephrine, glucagon, and ACTH.
Miotics
Agents causing contraction of the pupil of the eye. Some sources use the term miotics only for the parasympathomimetics but any drug used to induce miosis is included here.
Thyroid Gland
A highly vascularized endocrine gland consisting of two lobes joined by a thin band of tissue with one lobe on each side of the TRACHEA. It secretes THYROID HORMONES from the follicular cells and CALCITONIN from the parafollicular cells thereby regulating METABOLISM and CALCIUM level in blood, respectively.
Receptors, Peptide
Cell surface receptors that bind peptide messengers with high affinity and regulate intracellular signals which influence the behavior of cells.
Islet Amyloid Polypeptide
A pancreatic beta-cell hormone that is co-secreted with INSULIN. It displays an anorectic effect on nutrient metabolism by inhibiting gastric acid secretion, gastric emptying and postprandial GLUCAGON secretion. Islet amyloid polypeptide can fold into AMYLOID FIBRILS that have been found as a major constituent of pancreatic AMYLOID DEPOSITS.
Rats, Sprague-Dawley
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
Bone Resorption
Bone loss due to osteoclastic activity.
Neurons, Afferent
Neurons which conduct NERVE IMPULSES to the CENTRAL NERVOUS SYSTEM.
Radioimmunoassay
Classic quantitative assay for detection of antigen-antibody reactions using a radioactively labeled substance (radioligand) either directly or indirectly to measure the binding of the unlabeled substance to a specific antibody or other receptor system. Non-immunogenic substances (e.g., haptens) can be measured if coupled to larger carrier proteins (e.g., bovine gamma-globulin or human serum albumin) capable of inducing antibody formation.
Trigeminal Ganglion
The semilunar-shaped ganglion containing the cells of origin of most of the sensory fibers of the trigeminal nerve. It is situated within the dural cleft on the cerebral surface of the petrous portion of the temporal bone and gives off the ophthalmic, maxillary, and part of the mandibular nerves.
Calcium
A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.
Hypocalcemia
Reduction of the blood calcium below normal. Manifestations include hyperactive deep tendon reflexes, Chvostek's sign, muscle and abdominal cramps, and carpopedal spasm. (Dorland, 27th ed)
Osteoclasts
A large multinuclear cell associated with the BONE RESORPTION. An odontoclast, also called cementoclast, is cytomorphologically the same as an osteoclast and is involved in CEMENTUM resorption.
Vasoactive Intestinal Peptide
A highly basic, 28 amino acid neuropeptide released from intestinal mucosa. It has a wide range of biological actions affecting the cardiovascular, gastrointestinal, and respiratory systems and is neuroprotective. It binds special receptors (RECEPTORS, VASOACTIVE INTESTINAL PEPTIDE).
Ganglia, Spinal
Sensory ganglia located on the dorsal spinal roots within the vertebral column. The spinal ganglion cells are pseudounipolar. The single primary branch bifurcates sending a peripheral process to carry sensory information from the periphery and a central branch which relays that information to the spinal cord or brain.
Calcium Gluconate
The calcium salt of gluconic acid. The compound has a variety of uses, including its use as a calcium replenisher in hypocalcemic states.
Peptide Fragments
Partial proteins formed by partial hydrolysis of complete proteins or generated through PROTEIN ENGINEERING techniques.
Nerve Fibers
Slender processes of NEURONS, including the AXONS and their glial envelopes (MYELIN SHEATH). Nerve fibers conduct nerve impulses to and from the CENTRAL NERVOUS SYSTEM.
Bone Density Conservation Agents
Agents that inhibit BONE RESORPTION and/or favor BONE MINERALIZATION and BONE REGENERATION. They are used to heal BONE FRACTURES and to treat METABOLIC BONE DISEASES such as OSTEOPOROSIS.
Dose-Response Relationship, Drug
The relationship between the dose of an administered drug and the response of the organism to the drug.
Trigeminal Nerve
The 5th and largest cranial nerve. The trigeminal nerve is a mixed motor and sensory nerve. The larger sensory part forms the ophthalmic, mandibular, and maxillary nerves which carry afferents sensitive to external or internal stimuli from the skin, muscles, and joints of the face and mouth and from the teeth. Most of these fibers originate from cells of the TRIGEMINAL GANGLION and project to the TRIGEMINAL NUCLEUS of the brain stem. The smaller motor part arises from the brain stem trigeminal motor nucleus and innervates the muscles of mastication.
Neurokinin A
A mammalian neuropeptide of 10 amino acids that belongs to the tachykinin family. It is similar in structure and action to SUBSTANCE P and NEUROKININ B with the ability to excite neurons, dilate blood vessels, and contract smooth muscles, such as those in the BRONCHI.
RNA, Messenger
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Hydroxyproline
A hydroxylated form of the imino acid proline. A deficiency in ASCORBIC ACID can result in impaired hydroxyproline formation.
Peptides
Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.
Rats, Wistar
A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.
Neuropeptide Y
A 36-amino acid peptide present in many organs and in many sympathetic noradrenergic neurons. It has vasoconstrictor and natriuretic activity and regulates local blood flow, glandular secretion, and smooth muscle activity. The peptide also stimulates feeding and drinking behavior and influences secretion of pituitary hormones.
Hypercalcemia
Abnormally high level of calcium in the blood.
Vasodilation
The physiological widening of BLOOD VESSELS by relaxing the underlying VASCULAR SMOOTH MUSCLE.
Bone and Bones
A specialized CONNECTIVE TISSUE that is the main constituent of the SKELETON. The principle cellular component of bone is comprised of OSTEOBLASTS; OSTEOCYTES; and OSTEOCLASTS, while FIBRILLAR COLLAGENS and hydroxyapatite crystals form the BONE MATRIX.
Immunohistochemistry
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
Migraine Disorders
A class of disabling primary headache disorders, characterized by recurrent unilateral pulsatile headaches. The two major subtypes are common migraine (without aura) and classic migraine (with aura or neurological symptoms). (International Classification of Headache Disorders, 2nd ed. Cephalalgia 2004: suppl 1)
Hormones, Ectopic
Hormones released from neoplasms or from other cells that are not the usual sources of hormones.

Disruption of estrogen signaling does not prevent progesterone action in the estrogen receptor alpha knockout mouse uterus. (1/1409)

Estrogen is known to increase progesterone receptor (PR) levels in the wild-type mouse uterus, and this estrogen induction was thought to be important for progesterone action through the PR. The estrogen receptor alpha knockout (ERKO) mouse uterus was observed to express PR mRNA that cannot be induced by estrogen. Progesterone action was characterized to determine whether it was diminished in ERKO mice. The PR protein is present in the ERKO uterus at 60% of the level measured in a wild-type uterus. The PR-A and PR-B isoforms are both detected on Western blot, and the ratio of isoforms is the same in both genotypes. Although the level of PR is reduced in the ERKO uterus, the receptor level is sufficient to induce genomic responses, since both calcitonin and amphiregulin mRNAs were increased after progesterone treatment. Finally, the ERKO uterus can be induced to undergo a progesterone-dependent decidual response. Surprisingly, the decidual response is estrogen independent in the ERKO, although it remains estrogen dependent in a wild type. These results indicate that estrogen receptor alpha modulation of PR levels is not necessary for expression of the PR or genomic and physiologic responses to progesterone in the ERKO uterus.  (+info)

A prospective study of bone loss and turnover after allogeneic bone marrow transplantation: effect of calcium supplementation with or without calcitonin. (2/1409)

Transplantation of solid organs including heart, kidney, and liver is associated with rapid bone loss and increased rate of fracture; data on bone marrow transplantation recipients (BMT) are scarce. The purpose of the present study was to examine the magnitude, timing, and mechanism of bone loss following allogeneic BMT, and to study whether bone loss can be prevented by calcium with or without calcitonin. Sixty-nine patients undergoing allogeneic BMT for malignant blood diseases were enrolled into the study. Forty-four (22 women, 22 men) completed 6 months, and 36 patients 1 year follow-up. They were randomized to receive either no additional treatment (n = 22), or oral calcium 1 g twice daily for 12 months (n = 12) or the same dose of calcium plus intranasal calcitonin 400 IU/day for the first month and then 200 IU/day for 11 months (n = 10). Bone mineral density (BMD) at the lumbar spine and three femoral sites (femoral neck, trochanter, Ward's triangle) was measured by dual-energy X-ray absorptiometry (DXA). Bone turnover rate was followed with markers of bone formation and resorption (serum bone-specific alkaline phosphatase (B-ALP), type I procollagen carboxyterminal (PICP) and aminoterminal propeptide (PINP), serum type I collagen carboxyterminal telopeptide (ICTP)). Serum testosterone was assayed in men. Calcium with or without calcitonin had no effect on bone loss or bone markers; consequently the three study groups were combined. During the first 6 post-transplant months BMD decreased by 5.7% in the lumbar spine and by 6.9% to 8.7% in the three femoral sites (P < 0.0001 for all); no significant further decline occured between 6 and 12 months. Four out of 25 assessable patients experienced vertebral compression fractures. Markers of bone formation reduced: B-ALP by 20% at 3 weeks (P = 0.027), PICP by 40% (P < 0.0001) and PINP by 63% at 6 weeks (P < 0.0001), with a return to baseline by 6 months. The marker of bone resorption, serum ICTP was above normal throughout the whole observation period, with a peak at 6 weeks (77% above baseline, P < 0.0001). In male patients serum testosterone decreased reaching a nadir (57% below baseline) at 6 weeks (P = 0.0003). In conclusion, significant bone loss occurs after BMT. It results from imbalance between reduced bone formation and increased bone resorption; hypogonadism may be a contributing factor in men. Bone loss can not be prevented by calcium with or without calcitonin.  (+info)

Study of the cell biology and biochemistry of cherubism. (3/1409)

AIMS: To establish whether the multinucleate cells in lesions of patients with cherubism are also osteoclasts and if this is the case whether they were responsive to calcitonin; to carry out cytogenetic studies on two members of the same family affected by cherubism in an attempt to identify any major chromosomal defects; and to perform an in-depth modern biochemical study of four children in the same family. SUBJECTS AND METHODS: Four related children with cherubism were studied. Tissue taken from one of the children at elective decompression of an optic nerve was submitted to in vitro bone resorption studies. Cytogenetic studies were done on two of the children and biochemical studies on all four. RESULTS: The multinucleate cells in the cherubic lesions were shown to be osteoclasts since they synthesised tartrate resistant acid phosphatase, expressed the vitronectin receptor, and resorbed bone. Bone resorption by the cultured multinucleate cells was significantly inhibited by calcitonin. High resolution cytogenetic studies failed to detect any chromosomal abnormalities in two children with cherubism. The biochemistry profile of all four children with cherubism showed that serum calcium, parathyroid hormone, parathyroid related hormone, calcitonin, and alkaline phosphatase were within normal levels. Urine analysis of pyridinium and deoxypyridinium cross links, hydroxyproline, and calcium in relation to urine creatinine were measured to assess bone resorption in these children, and the values were at the upper end of the normal range in all four. CONCLUSIONS: Further studies are required to determine whether calcitonin treatment will control this grossly deforming disease until the time when the physiological changes that occur at puberty rectify the pathology. It is not recommended that biochemical markers of bone resorption are used in isolation to monitor the activity of cherubism in individuals because the results are based on a small number of children and because of reports of marked interindividual variation in the levels of these markers, particularly in children.  (+info)

Gastroenteropancreatic neuroendocrine tumor metastases to the thyroid gland: differential diagnosis with medullary thyroid carcinoma. (4/1409)

Neuroendocrine tumors (NET) of the thyroid gland are rare. Apart from medullary thyroid carcinoma (MTC), metastases of gastroenteropancreatic (GEP) NET may also occur. Features of six patients (five men, one female: age range, 39-67 years) with thyroid metastases from a GEP-NET are described. Thyroid metastases were bilateral in all patients and were associated with enlarged neck lymph nodes in five. In four cases, the thyroid tumor was either the first sign of the disease (n = 2) or was an isolated site of recurrence (n = 2). The tumors were well (n = 3) or poorly differentiated (n = 3). Five tumors for which the primary site could be determined corresponded to foregut-derived tumors (3 lungs, 1 thymus and 1 pancreatic NET). One tumor demonstrated calcitonin (CT) production as shown by immunohistochemistry and elevated plasma CT levels. However, the disease history and the clinical features strongly favored a metastasizing GEP-NET. No tumoral RET proto-oncogene mutation was found in this patient. The differential diagnosis between metastatic GEP-NET and MTC is crucial because prognosis, work-up, and treatment differ greatly.  (+info)

Roles of circulating carcinoembryonic antigen and calcitonin in diagnosis of medullary thyroid carcinoma: a comparative study. (5/1409)

Carcinoembryonic antigen (CEA) and calcitonin (CT) were simultaneously determined in sera and tumor tissues from 15 patients with medullary carcinoma of the thyroid (MCT). Serum CEA was increased in all but one patient, and CT did in all of them. Both levels were significantly related to the weight of excised tumor, but not to the presence of metastasis. Furthermore, a significant correlation was noted between the basal levels of CT and CEA. Both levels fell to normal after a radical operation had been performed. Tissue concentrations of CEA and CT in the MCT were more than 100 times those in hyperthyroidism, and the ratios of tissue over serum levels averaged 770 in CEA and 1000 in CT. In the calcium infusion test, CEA levels were not significantly changed in contrast with a distinct increase in CT levels. The results indicate that CEA and CT represent separate activities of the tumor cells, and that circulating CEA together with CT is a useful indicator in the diagnosis and follow-up of the disease.  (+info)

Glucocorticoid-induced secondary osteopenia in female rats: a time course study as compared with ovariectomy-induced osteopenia and response to salmon calcitonin. (6/1409)

Previously we reported that 8-week treatment with methylprednisolone acetate (MPA: 0.1 mg/kg, s.c., 3 days a week) of male rats caused a novel type of osteopenia whose development was prevented by salmon calcitonin (SCT) in a dose-dependent manner. In this study, to compare the MPA-inducible osteopenia with the ovariectomy (OVX)-inducible one, female rats were used instead of male rats and a time-course study of development was made. MPA treatments for 1, 2, 4 and 8 weeks histologically induced characteristic osteopenic changes in a time-dependent manner that were histomorphometrically detectable in tibiae within 4 weeks as reduced bone mass, accelerated bone resorption, and suppressed bone formation and mineralization. Node-strut analysis revealed that the connectivity of the trabecular structure remained unaffected. Such MPA-induced changes in the trabecular structure, to be defined as thinned-but-uncut, is in a good contrast with OVX-induced unthinned-but-cut structure, although the latter osteopenic changes became detectable 2 weeks earlier. Another previous finding confirmed herein was that MPA-induced osteopenia in female rats was also completely masked by SCT (10 U/kg, s.c., 5 days a week). The results indicate that the MPA-inducible secondary osteopenic model in either sex of rats would be usable for testing anti-osteopenic drugs.  (+info)

Protein kinase C antagonizes pertussis-toxin-sensitive coupling of the calcitonin receptor to adenylyl cyclase. (7/1409)

The calcitonin receptor is known to couple to Gs and Gq, activating adenylyl cyclase and phospholipase C, respectively. The observation of pertussis-toxin-sensitive responses to calcitonin suggests that the receptor is capable of coupling to Gi/o as well. However, the calcitonin-dependent activation of adenylyl cyclase in HEK-293 cells that stably express the cloned rabbit calcitonin receptor, as in many other cells that express calcitonin receptors, shows little pertussis toxin sensitivity. Calcitonin treatment of these cells stimulates protein kinase C, which is reported to antagonize the receptor-dependent activation of Gi. The possibility that protein kinase C could be antagonizing Galphai-adenylyl cyclase coupling was tested by examining the effects of protein kinase C inhibitors (chelerythrine chloride and sphingosine) or of chronic treatment with phorbol ester to deplete protein kinase C. All three treatments led to a reduction of calcitonin-induced adenylyl cyclase activity that was reversed by pertussis toxin. Inhibiting or depleting protein kinase C had no effect on the activation of adenylyl cyclase by cholera toxin, indicating that Gs and adenylyl cyclase were not affected by these treatments. Calcitonin treatment of HEK-293 cells, that stably express a myc-tagged rabbit calcitonin receptor, induced the formation of complexes of the receptor and Galphai subunits, confirming that the calcitonin receptor interacts with Gi. Thus, the calcitonin receptor can couple to Gi, but the inhibition of adenylyl cyclase by Galphai is negatively regulated by protein kinase C.  (+info)

A transient increase in renal clearance of phosphate in response to continuous infusion of salmon calcitonin in rats. (8/1409)

The effects of intravenous carrier-free salmon calcitonin on renal clearances of phosphate, calcium, magnesium, sodium and potassium were studied in male parathyroid-ectomized (PTX) and intact rats. Both natural and synthetic hormone, when infused at constant rates (0.005 approximately 0.5 MRC U/hr), produced a rapid increase (peaking at about 60-90 min) in phosphate clearance. However, the maximal increase was transient in nature in PTX rats. In intact rats, the phosphaturic response was somewhat more pronounced and the decline after the peak was rather modest. When a large amount (4 MRC U) of calcitonin was given in divided doses, the second dose produced a lesser extent of phosphaturia in both intact and PTX rats. The phosphaturic response was accompanied by an increase in sodium and potassium clearances in PTX rats and by an increase in potassium clearance in intact rats. A fall in the apparent clearance values for calcium and magnesium occurred and was maintained throughout the infusion period of hormone in both intact and PTX rats. In conclusion, PTX rats respond to the intravenous administration of salmon calcitonin with a transient phosphaturic response which is accompanied by parallel diuresis of sodium and potassium along with sustained retention of calcium and magnesium by the kidney.  (+info)

Effect of early oral calcium supplementation on serum calcium and immunoreactive calcitonin concentration in preterm infants. |...Effect of early oral calcium supplementation on serum calcium and immunoreactive calcitonin concentration in preterm infants. |...
Oral calcium supplements (80 mg/kg per 24 h) were given to 23 preterm infants, and the course of serum calcium, magnesium, immunoreactive calcitonin, and gastrin was compared with a control group of 23 matched infants. In the supplemented group, serum calcium concentrations remained at the baseline level (2.31 mmol/l +/- 0.18 SD) while a fall (from 2.27 +/- 0.18 to 1.91 +/- 0.24 mmol/l) was observed at 12-16 hours of age in the control group, with 4 values , 1.75 mmol/l. There was no change in serum magnesium concentration in either group. The postnatal rise of serum immunoreactive calcitonin concentrations in the control group (from 171 +/- 135 to 493 +/- 273 pg/ml at 12-48 hours of age) was not found in the supplemented group. There was a negative correlation between serum calcium and immunoreactive calcitonin levels in the control group, but not in the supplemented group. There was no correlation between serum immunoreactive calcitonin and gastrin concentrations. These data show that oral ...
http://adc.bmj.com/content/55/8/611
Inactivation of porcine calcitonin by rat kidney microsome | Meta
Biological activity of porcine calcitonin was most actively inactivated by the rat kidney homogenate than by other tissue homogenates. Among the various subcellular fractions of the rat kidney homogenate examined, microsome fraction was most active in the in vitro inactivation of porcine calcitonin. Inactivation of porcine calcitonin by the rat kidney microsome was dependent on pH and temperature. Inactivating activity of the rat kidney microsome was inhibited by 1 X 10(-3) M monoiodoacetate and 1 X10(-5) M p-chloromercuribenzoate. These results suggest that porcine calcitonin is probably inactivated by a SH-enzyme in the rat kidney microsomes. However, the participation of other enzymes cannot be ruled out, since the inactivating activity of the rat kidney microsome fraction is also inhibited by 1 X 10(-4) M diisopropylfuorophosphate. ...
https://www.meta.org/papers/inactivation-of-porcine-calcitonin-by-rat-kidney/8306
PO-0187 Value Of Serum Procalcitonin Level In Differentiation Of Viral And Bacterial Meningitis In Children Admitted Emergency...PO-0187 Value Of Serum Procalcitonin Level In Differentiation Of Viral And Bacterial Meningitis In Children Admitted Emergency...
Results There is no significant difference between two groups, in age, Sex, and symptoms. Serum and CSF procalcitonin, Leukocytosis ,15000, PMN peleocytosis of CSF and also sugarand protein of CSF were significantly higher in bacterial meningitis. Serum and CSF procalcitonin levels in control group were less than 0.5 ng/ml and ,2 ng/ml in bacterial meningitis and only one child (8.33%) in aseptic meningitis (Herpes meningoencephalitis) had serum procalcitonin more than 2 ng/ml same bacterial meningitis.. ...
http://adc.bmj.com/content/99/Suppl_2/A308.1
Serum Procalcitonin Predicts Anastomotic Leaks in Colorectal Surgery | Physicians Weekly for Medical News, Journals & ArticlesSerum Procalcitonin Predicts Anastomotic Leaks in Colorectal Surgery | Physicians Weekly for Medical News, Journals & Articles
Background: Anastomotic leaks in colorectal surgery results in a high morbidity and mortality rate. Serum procalcitonin levels is known as a sensitive and specific marker of sepsis and could be use as a marker for early detection of a leak allowing early intervention. It may help a clinician decide to perform a CT scan even earlier especially when the diagnosis of a leak is uncertain. The aim of this study is to determine whether serum procalcitonin is a good predictor of anastomotic leak in colorectal surgery. Methodology: Between July 2014 until October 2015, 70 patients undergoing colorectal surgery were prospectively analyzed in a single-center tertiary teaching hospital. Demographic and surgical data were obtained. Serum procalcitonin was taken before surgery and at day 3 (72 hours) postoperatively. During the postoperative period, the patients were observed in the ward for features of anastomotic leak and if present, it was managed accordingly. The primary outcome was to prospectively ...
https://www.physiciansweekly.com/serum-procalcitonin-predicts-anastomotic-leaks-in-colorectal-surgery/
Ultrasonographic Features of Medullary Thyroid Carcinoma: Do they Correlate with Pre and PostOperative Calcitonin LevelsUltrasonographic Features of Medullary Thyroid Carcinoma: Do they Correlate with Pre and PostOperative Calcitonin Levels
Purpose: To correlate ultrasonographic (US) features of medullary thyroid carcinoma (MTC) with pre operative and postoperative calcitonin levels. Materials and Methods: A total of 130 thyroid nodules diagnosed as MTC were evaluated. Two radiologists retrospectively evaluated preoperative US features according to size, shape, margin, echogenicity, type of calcification, and lymph node status. Postoperative clinical and imaging followup (mean duration 31.9 22.5 months) was performed for detection of tumor recurrence. US features, presence of LN metastasis, and tumor recurrence were compared between MTC nodules with and without elevated preoperative calcitonin (|100 pg/mL). Those with normalized and nonnormalized postoperative calcitonin levels groups were also compared. Results: Common US features of MTCs were solid internal content (90.8%), irregular shape (44.6%), circumscribed margin (46.2%), and hypoechogenicity (56.2%). Comparing MTC nodules with and without elevated preoperative calcitonin levels,
http://journal.waocp.org/article_32521.html
Further studies on the mode of action of calcitonin on isolated rat osteoclasts: pharmacological evidence for a second site...
Calcitonin is a circulating polypeptide that inhibits bone resorption by inducing both quiescence (Q effect) and retraction (R effect) in osteoclasts. Two structurally related members of the calcitonin gene peptide family, calcitonin gene-related peptide (CGRP) and amylin, inhibit osteoclastic bone resorption selectively via the Q effect. In the present study, we have made measurements of cell spread area in response to the application of amylin, CGRP and a peptide fragment of CGRP, CGRP-(Val8Phe37). We found that, over a wide concentration range (50 pmol/l to 2.5 mumol/l), the selective Q effect agonists did not produce an R effect. Furthermore, the peptides, when used at a 50-fold higher molar concentration than calcitonin, did not antagonize calcitonin-induced cell retraction. Additionally, experiments designed to measure changes in the intracellular free calcium concentration ([Ca2+]i) in single osteoclasts revealed that, unlike calcitonin, the non-calcitonin Q effect agonists did not produce a rise
https://www.ndorms.ox.ac.uk/publications/475698
Maternal serum procalcitonin levels in prediction of chorioamnionitis in women with preterm premature rupture of membranes ...Maternal serum procalcitonin levels in prediction of chorioamnionitis in women with preterm premature rupture of membranes ...
Introduction: Chorioamnionitis is one of the most important maternal complications in the expectant management of patients with preterm premature rupture of membranes (PPROM). Procalcitonin (proCT), the precursor of the hormone calcitonin, is used to differentiate bacterial infections from...
https://www.archivesofmedicalscience.com/Maternal-serum-procalcitonin-levels-in-prediction-nof-chorioamnionitis-in-women-with,89786,0,2.html
Predicting bacteremia by procalcitonin levels in patients evaluated for sepsis in the emergency department - edocPredicting bacteremia by procalcitonin levels in patients evaluated for sepsis in the emergency department - edoc
Evaluation of: Riedel S, Melendez JH, An AT, Rosenbaum JE, Zenilman JM. Procalcitonin as a marker for the detection of bacteremia and sepsis in the emergency department. Am. J. Clin. Pathol. 135(2), 182-189 (2011). In a recent report, Riedel et al. proposed a procalcitonin cutoff of 0.1 ng/ml to rule out bacteremia in adult patients presenting to the emergency department with systemic infections. Procalcitonin levels were higher in patients with true bacteremia than in patients with negative blood cultures or bacteremia due to possible contaminants. For prediction of bacteremia, a procalcitonin level of 0.1 ng/ml had an excellent negative predictive value of 96.3%, and a good sensitivity of 75%, specificity of 70.6% and area under the curve of 0.73, but poor positive predictive value of 12.8%. Based on the results in this study, we propose that a procalcitonin value of 0.1 ng/ml or less could be used to rule out bacteremia (NPV: 96.3 ...
https://edoc.unibas.ch/31019/
Serval - Cytokines, nitrite/nitrate, soluble tumor necrosis factor receptors, and procalcitonin concentrations : comparisons in...Serval - Cytokines, nitrite/nitrate, soluble tumor necrosis factor receptors, and procalcitonin concentrations : comparisons in...
Cytokines, nitrite/nitrate, soluble tumor necrosis factor receptors, and procalcitonin concentrations : comparisons in patients with septic shock, cardiogenic shock, and bacterial pneumonia
https://serval.unil.ch/en/notice/serval:BIB_4FA339004525
Effect of procalcitonin-guided antibiotic treatment on clinical outcomes in intensive care unit patients with infection and...Effect of procalcitonin-guided antibiotic treatment on clinical outcomes in intensive care unit patients with infection and...
The clinical utility of serum procalcitonin levels in guiding antibiotic treatment decisions in patients with sepsis remains unclear. This patient-level meta-analysis based on 11 randomized trials investigates the impact of procalcitonin-guided antibiotic therapy on mortality in intensive care unit (ICU) patients with infection, both overall and stratified according to sepsis definition, severity, and type of infection. For this meta-analysis focusing on procalcitonin-guided antibiotic management in critically ill patients with sepsis of any type, in February 2018 we updated the database of a previous individual patient data meta-analysis which was limited to patients with respiratory infections only. We used individual patient data from 11 trials that randomly assigned patients to receive antibiotics based on procalcitonin levels (the
https://ccforum.biomedcentral.com/articles/10.1186/s13054-018-2125-7/figures/2
Calcitonin Related PeptidesCalcitonin Related Peptides
Peptides , Calcitonin Related Peptides; Calcitonin gene-related peptide (CGRP), adrenomedullin (ADM) and amylin belong to a unique group of calcitonin-related peptide hormones important for homeostasis in diverse tissues. Calcitonin, a 32-amino acid peptide hormone, is essential for calcium balance, whereas CGRP and ADM are important for neurotransmission and cardiovascular and respiratory function. Calcitonin regulates mineral balance by controlling blood concentrations of calcium and phosphorus metabolism and can cause hypercalcemia. An increase in the serum calcium level is known to stimulate calcitonin secretion. In mammals, the major source of calcitonin is from the parafollicular or C cells in the thyroid gland, but it is also synthesized in a wide variety of other tissues, including the lung and intestinal tract. Calcitonin contains a single disulfide bond, which causes the amino terminus to assume the shape of a ring. The calcitonin family of peptides act through G-protein protein coupled
https://www.anaspec.com/products/productcategory.asp?id=157
Serum procalcitonin for differential diagnosis of acute exacerbation and bacterial pneumonia in patients with interstitial lung...
TY - JOUR. T1 - Serum procalcitonin for differential diagnosis of acute exacerbation and bacterial pneumonia in patients with interstitial lung disease. AU - Sim, Jae Kyeom. AU - Oh, Jee Youn. AU - Lee, Eun Joo. AU - Hur, Gyu Young. AU - Lee, Seung Heon. AU - Lee, Sung Yong. AU - Lee, Sang Yeub. AU - Kim, Je Hyeong. AU - Shin, Chol. AU - Shim, Jae Jeong. AU - In, Kwang Ho. AU - Kang, Kyung Ho. AU - Min, Kyung Hoon. N1 - Funding Information: This study was supported by a grant from Korea University , Seoul, Korea ( K1326181 ). PY - 2016. Y1 - 2016. N2 - Background: Acute exacerbation and bacterial pneumonia are major life-threatening conditions in patients with interstitial lung disease (ILD). The rapid recognition of these 2 different conditions is important for their proper treatment. An elevated procalcitonin (PCT) level is commonly detected in patients with bacterial infections. This study assessed the usefulness of the serum PCT level as a biomarker for the differential diagnosis of acute ...
https://koreauniv.pure.elsevier.com/en/publications/serum-procalcitonin-for-differential-diagnosis-of-acute-exacerbat
164750: Procalcitonin | LabCorp164750: Procalcitonin | LabCorp
PCT is the prohormone of the hormone calcitonin, but PCT and calcitonin are distinct proteins. Calcitonin is exclusively produced by C-cells of the thyroid gland in response to hormonal stimuli, whereas PCT can be produced by several cell types and many organs in response to proinflammatory stimuli, in particular by bacterial products.1. In healthy people, plasma PCT concentrations are found to be below 0.1 μg/L.2 Depending on the clinical background, a PCT concentration above 0.1 μg/L can indicate clinically relevant bacterial infection, requiring antibiotic treatment.3 PCT levels rise rapidly (within 6 to 12 hours) after a bacterial infectious insult with systemic consequences. The magnitude of the increase in PCT concentration correlates with the severity of the bacterial infection.4 At a PCT concentration ,0.5 μg/L, a patient should be considered at risk of developing severe sepsis or septic shock.5,6 On the other hand, the relief of the septic infection is accompanied by a decrease in ...
https://www.labcorp.com/test-menu/33581/procalcitonin
The biochemical and histological analysis of subcutaneous calcitonin and intramedullary methylprednisolone on bone repair after...The biochemical and histological analysis of subcutaneous calcitonin and intramedullary methylprednisolone on bone repair after...
Although, glucocorticoid (GC) and calcitonin-induced changes in bone repair have been studied previously, the exact effects of these on fracture healing remain controversial. Hence, the purpose of this experimental study is to determine biochemical and histological effects of locally administrated GC and systemically administrated calcitonin on the kinetics of healing response after bone marrow ablation in rats. After having undergone marrow ablation, a steroid-treated group of rats (n = 24) received a single dose of intramedullary methylprednisolone (2 mg/kg), a calcitonin-treated group (n = 24) received intermittently administrated subcutaneous salmon calcitonin (16 IU/kg), and a control group (n = 24) received intramedullary saline (25 μl). Blood samples taken on days 1, 3, 7, 9, and 15 after ablation showed an increase in serum calcium, alkaline phosphatase (ALP), and phosphate levels in the Calcitonin and Control groups. Levels of calcium and ALP peaked on day 7 after ablation. However, an
https://jeo-esska.springeropen.com/articles/10.1186/s40634-017-0100-x
Clinical screening as compared with DNA analysis in families with multiple endocrine neoplasia type 2A
Of 80 MEN2A gene carriers (in 61 of whom carrier status was proved by DNA analysis), 66 had abnormal plasma calcitonin values and medullary thyroid carcinoma. Fourteen young carriers had normal results of plasma calcitonin tests. In 8 of these 14, thyroidectomy revealed small foci of medullary thyroid carcinoma; the remaining 6 have not yet been operated on. Of the other 220 family members, 68 were found by DNA analysis not to carry the MEN2A gene. None of these 68 subjects had medullary thyroid carcinoma or pheochromocytoma; 6 had elevated plasma calcitonin concentrations and underwent thyroidectomy but had only C-cell hyperplasia. Conclusions: ...
https://www.meb.uni-bonn.de/cgi-bin/mycite?ExtRef=MEDL/94359543/PMID/7915822
The Effects Of Thyrocalcintonin On Fibula Regeneration In The Albino RatThe Effects Of Thyrocalcintonin On Fibula Regeneration In The Albino Rat
Fifteen eight-week-old female Sprague Dawley rats were used to determine the effects of thyrocalcitonin on osteogenic regeneration. Bone fragments of 2.8-5.3 mm were extracted from the mid-shaft of the right hind fibulae. Following surgery, seven control animals were administered saline for twenty consecutive days, whereas eight experimental animals were injected subcutaneously with 7.5 mMRC/200 g body wt of thyrocalcitonin for twenty consecutive days. After experimentation was complete, the rats were sacrificed and morphological observations were made to quantify the lengths of fibulae gaps before and after treatment. Statistical analysis indicates that bone regeneration occurs at a faster rate in those animals receiving thyrocalcitonin ...
https://scholars.carroll.edu/handle/20.500.12647/3217
EPO - T 0157/90 () of 12.9.1991EPO - T 0157/90 () of 12.9.1991
Summary of Facts and Submissions. I. European patent application No. 82 303 667.8, relating to a human calcitonin precursor polyprotein structural gene, was published with number 0 070 675 with 17 claims. Claims 1 and 7 read as follows:. 1. A structural gene encoding a polypeptide comprising the amino acid sequence of human calcitonin, in which said polypeptide is processable to produce human calcitonin.. 7. A polypeptide containing the amino acid sequence of human calcitonin which is processable to produce human calcitonin.. II. In response to notifications issued by the Examining Division the Applicants (Appellants) filed new sets of claims on different occasions.. Finally, with a letter of 18 May 1988, a set of claims was filed whose Claim 1 reads as follows:. 1. A vector including a structural gene encoding a polypeptide comprising the amino acid sequence of human calcitonin and an additional amino acid at the C-terminus of the amino acid sequence of human calcitonin, wherein the ...
https://www.epo.org/law-practice/case-law-appeals/recent/t900157eu1.html
Procalcitonin - WikipediaProcalcitonin - Wikipedia
Procalcitonin (PCT) is a peptide precursor of the hormone calcitonin, the latter being involved with calcium homeostasis. It was first identified by Leonard J. Deftos and Bernard A. Roos in the 1970s. It is composed of 116 amino acids and is produced by parafollicular cells (C cells) of the thyroid and by the neuroendocrine cells of the lung and the intestine. The level of procalcitonin in the blood stream of healthy individuals is below the limit of detection (0.01 µg/L) of clinical assays. The level of procalcitonin rises in a response to a proinflammatory stimulus, especially of bacterial origin. It is therefore often classed as an acute phase reactant. In this case, it is produced mainly by the cells of the lung and the intestine.... It does not rise significantly with viral or non-infectious inflammations. With the derangements that a severe infection with an associated systemic response brings, the blood levels of procalcitonin may rise to 100 µg/L. In serum, procalcitonin has a ...
https://en.wikipedia.org/wiki/Procalcitonin
The Vitamin D Receptor in Thyroid Development and Function | DIAL.pr - BOREALThe Vitamin D Receptor in Thyroid Development and Function | DIAL.pr - BOREAL
Background and Objective: Vitamin D is known to modulate thyroid neoplastic and autoimmune disease. We investigated the role of the vitamin D receptor (VDR) in normal thyroid development and function (thyrocytes and C cells). Methods: The thyroid phenotype of VDR knockout mice was studied in comparison to wild-type controls. The mice were fed a normal diet or a calcium-rich diet to circumvent effects induced by hypocalcemia. Results: Thyroid morphology was unaltered in VDR knockout mice. Also, expression of different parameters of thyrocyte function was comparable (immunohistochemistry). C cell physiology was, however, affected in the absence of the VDR, resulting in increased thyroidal calcitonin expression (immunohistochemistry), paralleled by increased serum calcitonin levels, but only in normocalcemic mice. To study a possible effect of vitamin D status on basal calcitonin levels in humans, serum calcitonin concentrations were compared between vitamin D-deficient and -sufficient patients ...
https://dial.uclouvain.be/pr/boreal/object/boreal:123360
Patent US3926938 - Synthesis of salmon calcitonin - Google PatentsPatent US3926938 - Synthesis of salmon calcitonin - Google Patents
Resin peptides useful in the preparation of salmon calcitonin are disclosed along with processes for preparing the same. The invention also embraces peptides from which the resin moiety has been cleaved and which are useful in the synthesis of salmon calcitonin together with processes for preparing the cleaved peptides. In general, the processes involve the solid phase synthesis procedures.
http://www.google.com/patents/US3926938?dq=7751826
Serum procalcitonin as a marker of post-cardiac arrest syndrome and long-term neurological recovery, but not of early-onset...Serum procalcitonin as a marker of post-cardiac arrest syndrome and long-term neurological recovery, but not of early-onset...
OBJECTIVE: To examine the relationship of early serum procalcitonin (PCT) levels with the severity of post-cardiac arrest syndrome (PCAS), long-term neurological recovery and the risk of early-onset infections in patients with coma after cardiac arrest (CA) treated with therapeutic hypothermia (TH).. METHODS: A prospective cohort of adult comatose CA patients treated with TH (33°C, for 24h) admitted to the medical/surgical intensive care unit, Lausanne University Hospital, was studied. Serum PCT was measured early after CA, at two time-points (days 1 and 2). The SOFA score was used to quantify the severity of PCAS. Diagnosis of early-onset infections (within the first 7 days of ICU stay) was made after review of clinical, radiological and microbiological data. Neurological recovery at 3 months was assessed with Cerebral Performance Categories (CPC), and was dichotomized as favorable (CPC 1-2) vs. unfavorable (CPC 3-5).. RESULTS: From December 2009 to April 2012, 100 patients (median age 64 ...
https://read.qxmd.com/read/23380286/serum-procalcitonin-as-a-marker-of-post-cardiac-arrest-syndrome-and-long-term-neurological-recovery-but-not-of-early-onset-infections-in-comatose-post-anoxic-patients-treated-with-therapeutic-hypothermia
Effects of Water and Food Intake on the Pharmacokinetics and Pharmacodynamics of Oral Salmon Calcitonin in Healthy...Effects of Water and Food Intake on the Pharmacokinetics and Pharmacodynamics of Oral Salmon Calcitonin in Healthy...
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies. ...
https://clinicaltrials.gov/ct2/show/NCT00395395
Oral salmon calcitonin improves fasting and postprandial glycemic control in lean healthy rats. | Sigma-AldrichOral salmon calcitonin improves fasting and postprandial glycemic control in lean healthy rats. | Sigma-Aldrich
Sigma-Aldrich offers abstracts and full-text articles by [M Feigh, R H Nielsen, C Hansen, K Henriksen, C Christiansen, M A Karsdal].
https://www.sigmaaldrich.com/catalog/papers/22198815
ORBi: Browsing ORBiORBi: Browsing ORBi
in Pathologie Biologie (1997), 45(1), 52-6. There appears to be a consensus that 100 IU/day of nasally administered salmon calcitonin may prevent trabecular bone loss during the first years of the menopause. Strong evidence exists that half that ... [more ▼]. There appears to be a consensus that 100 IU/day of nasally administered salmon calcitonin may prevent trabecular bone loss during the first years of the menopause. Strong evidence exists that half that dose may also be sufficient to prevent trabecular bone loss and that higher doses (, or = 200 IU/day) induce a significant increase in spinal bone mineral content. Calcium supplements should be systemically administered when calcitonin is given, particularly at high doses. Rectal calcitonin seems also to be an efficient alternative in prevention of trabecular bone loss. Further studies are required to evaluate the effect of calcitonin in prevention of cortical bone loss. In established osteoporosis, calcitonin may prevent further bone loss ...
https://orbi.uliege.be/browse?type=journal&value=Pathologie+Biologie
Assessment of Procalcitonin as a Diagnostic Marker of Underlying Infection in Patients with Febrile Neutropenia : Clinical...
The novel inflammatory marker procalcitonin (PCT) was assessed as an index of infection in patients with febrile neutropenia. Blood samples were obtained from 115 patients with febrile neutropenia for determination of PCT levels before onset of fever and daily until the resolution of fever. The median PCT level on the first day of fever was 8.23 ng/mL in patients with bacteremia, compared with 0.86 ng/mL in patients with localized bacterial infections (P = .017). The median PCT level on the first day of fever was 2.62 ng/mL in patients with severe sepsis, compared with 0.57 ng/mL in patients with clinically localized infections (P , .001). A dramatic decrease in PCT levels was documented after resolution of the infection; PCT levels were elevated when the infection worsened. Pronounced PCT levels were also found in patients with fever of unknown origin who were responding to antimicrobial chemotherapy, compared with those not responding to treatment with antibiotics. PCT levels were particularly ...
http://oxfordindex.oup.com/view/10.1086/320744
Plus itPlus it
In HAP, CAP and, to a lesser extent, AECB, but not TB, significantly elevated median PCT levels were found compared to controls. However, median PCT levels in all groups were below the recommended cut-off level of 0.5 ng·mL−1. Therefore, according to the present study, PCT concentration seems not to be particularly useful for the detection of lower respiratory tract infections e.g. CRP. Similar results were obtained by Hedlund and Hansson 21, who compared CRP and PCT levels in CAP in adults. However, Moulin etal. 22 described a superiority of PCT over CRP concentration in paediatric patients with CAP. In the recent publication of Brunkhorst et al. 23, different results, with elevated PCT levels in patients with severe pneumonia, were demonstrated. In contrast to the present study, the latter study included only patients with severe pneumonia, who were treated in the intensive care unit. This could also be a reason for the elevated PCT levels. Although diagnostic value has not been proved, PCT ...
https://erj.ersjournals.com/content/21/6/939
Role of Serum Procalcitonin in Early Diagnosis of Neonatal Sepsis - NJMS IndiaRole of Serum Procalcitonin in Early Diagnosis of Neonatal Sepsis - NJMS India
Downlod pdf Article Sharma SK, Kumar A, Yadav B, Singh AK, Pathak R, Hussain M, Sherma A. Role of Serum Procalcitonin in Early Diagnosis of Neonatal Sepsis. National Journal of Medical and Allied Sciences 2015; 4(1):62-66. ...
https://www.njmsonline.org/role-of-serum-procalcitonin-in-early-diagnosis-of-neonatal-sepsis
Plus itPlus it
We have cloned and characterized a second form of the human calcitonin receptor from T47D cells. It resembles the clone described by Gorn et al. [J. Clin. Invest. 90:1726-1735 (1992)] except that it lacks a 16-amino acid insert in the putative first intracellular loop. The insert-negative receptor appears to be the most abundant form, and it occurs at a relatively constant level in all expressing tissues. In contrast, the insert-positive receptor is found at low levels in most tissues but its expression levels appear to be much more variable. The insert-negative cDNA was stably expressed in baby hamster kidney cells. Like the endogenous T47D receptor, the recombinant receptor has an equally high affinity for salmon and porcine calcitonin but a 3-4-fold lower affinity for human calcitonin. High concentrations of calcitonin gene-related peptide, rat amylin, secretin, or vasoactive intestinal peptide do not significantly compete with calcitonin for binding to the recombinant receptor. Calcitonin ...
https://molpharm.aspetjournals.org/content/46/2/246
Procalcitonin legal definition of ProcalcitoninProcalcitonin legal definition of Procalcitonin
Definition of Procalcitonin in the Legal Dictionary - by Free online English dictionary and encyclopedia. What is Procalcitonin? Meaning of Procalcitonin as a legal term. What does Procalcitonin mean in law?
https://legal-dictionary.thefreedictionary.com/Procalcitonin
FRMC Pharmacist Published With Procalcitonin Study
FRMC Pharmacy Director, Mike Broyles PharmD, has worked diligently for the past several years, crossing the country, educating Healthcare Representatives about Antibiotic Usage and improving patient outcomes. He recently completed a study in which he included data from over 2100 patients that had been treated at Five Rivers Medical Center. The study consisted of comparing data that was found with the patients who were treated with antibiotics prior to the use of a laboratory test called Procalcitonin (PCT) and those that were treated after the test was available. Procalcitonin (PCT) is a Peptide Precursor of the hormone Calcitonin. The level of Procalcitonin will rise in the presence of a bacterial infection. During the course of antibiotic treatment for these bacterial infections, PCT is measured to verify that the antibiotic administered is decreasing the level of PCT found circulating in the patients bloodstream. If not, Antibiotics might need to be adjusted or changed. As PCT decreases, the ...
http://www.fiveriversmc.com/2017/11/frmc-pharmacist-gets-published-nationally/
Calcium Metabolism and 47Calcium Kinetics before and after Long-Term Thyrocalcitonin Treatment in Senile Osteoporosis |...Calcium Metabolism and 47Calcium Kinetics before and after Long-Term Thyrocalcitonin Treatment in Senile Osteoporosis |...
Thank you for your interest in spreading the word about Clinical Science.. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.. ...
http://www.clinsci.org/content/38/4/397
Prostaglandin E<sub>2</sub> enhances bradykinin-stimulated release of neuropeptides from rat sensory neurons in...
TY - JOUR. T1 - Prostaglandin E2 enhances bradykinin-stimulated release of neuropeptides from rat sensory neurons in culture. AU - Vasko, M. R.. AU - Campbell, W. B.. AU - Waite, K. J.. PY - 1994/8/1. Y1 - 1994/8/1. N2 - Prostaglandins are known to enhance the inflammatory and nociceptive actions of other chemical mediators of inflammation such as bradykinin. One possible mechanism for this sensitizing action is that prostanoids augment the release of neuroactive substances from sensory neurons. To initially test this hypothesis, we examined whether selected prostaglandins could enhance the resting or bradykinin-evoked release of immunoreactive substance P (iSP) and/or immunoreactive calcitonin gene-related peptide (iCGRP) from sensory neurons in culture. Bradykinin alone causes a concentration-dependent increase in the release of iSP and iCGRP from isolated sensory neurons, and this action is abolished in the absence of extracellular calcium. Pretreating the neurons with PGE2 (10 nM to 1 μM) ...
https://indiana.pure.elsevier.com/en/publications/prostaglandin-esub2sub-enhances-bradykinin-stimulated-release-of-
SMC021A - Absorption, Efficacy and Tolerance in Patients With Osteoarthritis. A Placebo-Controlled 14-Days Study - Full Text...SMC021A - Absorption, Efficacy and Tolerance in Patients With Osteoarthritis. A Placebo-Controlled 14-Days Study - Full Text...
The purpose of this study is to expose patients with OA to calcitonin and to determine plasma calcitonin levels after administration of 0.6 mg and 0.8 mg oral calcitonin. Also the purpose is to assess the effect of different doses of oral calcitonin (0.6 mg and 0.8 mg oral) compared to placebo on serum CTX-I and CTX-II. Finally to assess the tolerance profile of different doses/formulations of oral calcitonin compared to placebo ...
https://clinicaltrials.gov/ct2/show/NCT00486369
Procalcitonin | Article about Procalcitonin by The Free DictionaryProcalcitonin | Article about Procalcitonin by The Free Dictionary
Looking for Procalcitonin? Find out information about Procalcitonin. A protocol from Microsoft that provides secure transactions over the Web. See security protocol Explanation of Procalcitonin
http://encyclopedia2.thefreedictionary.com/Procalcitonin
Regional oral absorption, hepatic first-pass effect, and non-linear disposition of salmon calcitonin in beagle dogs.
The dose-dependent disposition, first pass hepatic elimination, and absorption pharmacokinetics (PK) of salmon calcitonin (sCT) were investigated in a canine Intestinal Vascular Access Port (IVAP) model. The PK of sCT were determined after intravenou
http://www.biomedsearch.com/nih/Regional-oral-absorption-hepatic-first/10962228.html
The Interaction between Amyloid Prefibrillar Oligomers of Salmon Calcitonin and a Lipid-Raft Model: Molecular Mechanisms...
Fingerprint Dive into the research topics of The Interaction between Amyloid Prefibrillar Oligomers of Salmon Calcitonin and a Lipid-Raft Model: Molecular Mechanisms Leading to Membrane Damage, Ca2+-Influx and Neurotoxicity. Together they form a unique fingerprint. ...
https://moh-it.pure.elsevier.com/en/publications/the-interaction-between-amyloid-prefibrillar-oligomers-of-salmon-/fingerprints/
Global Salmon Calcitonin Market 2020-2024, Trends and Forecast Report, Trends, Share, Size Research ReportGlobal Salmon Calcitonin Market 2020-2024, Trends and Forecast Report, Trends, Share, Size Research Report
Global Salmon Calcitonin Market 2020-2024, Trends and Forecast Report Size and Share Published in 2019-12-26 Available for US$ 2850 at Researchmoz.us
https://www.researchmoz.us/global-salmon-calcitonin-market-2020-2024-trends-and-forecast-report-report.html
Calcitonin - wikidocCalcitonin - wikidoc
High concentrations of calcitonin may be able to increase urinary excretion of calcium and phosphate via the renal tubules.[9] leading to marked hypocalcemia. However, this is a minor effect with no physiological significance in humans. It is also a short-lived effect because the kidneys become resistant to calcitonin, as demonstrated by the kidneys unaffected excretion of calcium in patients with thyroid tumors that secrete excessive calcitonin.[10] In its skeleton-preserving actions, calcitonin protects against calcium loss from skeleton during periods of calcium mobilization, such as pregnancy and, especially, lactation. The protective mechanisms include the direct inhibition of bone resorption and the indirect effect through the inhibition of the release of prolactin from the pituitary gland. The reason provided is that prolactin induces the release of PTH related peptide which enhances bone resorption, but is still under investigation.,[11][12][13] Other effects are in preventing ...
https://wikidoc.org/index.php/Calcitonin
Author: Chen, Szu-Yu / Journal: Biomaterials / Subject: 5 selected - PubAg Search ResultsAuthor: Chen, Szu-Yu / Journal: Biomaterials / Subject: 5 selected - PubAg Search Results
Human disc degeneration initiated by aging in the central nucleus pulposus (hNP) is an irreversible process and the recovery has become seriously emerging. In this study, the related mechanisms of calcitonin on the regeneration of hNP and the effects of calcitonin on the age-related alterations were examined. The harvested hNP population was designated as YhNP (from young donor, age ...
https://pubag.nal.usda.gov/?f%5Bjournal_name%5D%5B%5D=Biomaterials&f%5Bsubject_term%5D%5B%5D=calcitonin+receptors&f%5Bsubject_term%5D%5B%5D=cyclic+AMP&f%5Bsubject_term%5D%5B%5D=chondrogenesis&f%5Bsubject_term%5D%5B%5D=humans&f%5Bsubject_term%5D%5B%5D=phenotype&per_page=50&q=%22Chen%2C+Szu-Yu%22&search_field=author&sort=title
Author: Chen, Szu-Yu / Journal: Biomaterials / Subject: 3 selected - PubAg Search ResultsAuthor: Chen, Szu-Yu / Journal: Biomaterials / Subject: 3 selected - PubAg Search Results
Human disc degeneration initiated by aging in the central nucleus pulposus (hNP) is an irreversible process and the recovery has become seriously emerging. In this study, the related mechanisms of calcitonin on the regeneration of hNP and the effects of calcitonin on the age-related alterations were examined. The harvested hNP population was designated as YhNP (from young donor, age ...
https://pubag.nal.usda.gov/?f%5Bjournal_name%5D%5B%5D=Biomaterials&f%5Bsubject_term%5D%5B%5D=cyclic+AMP&f%5Bsubject_term%5D%5B%5D=chondrogenesis&f%5Bsubject_term%5D%5B%5D=calcitonin+receptors&per_page=50&q=%22Chen%2C+Szu-Yu%22&search_field=author&sort=date-asc
Most recent papers with the keyword antibiotic bronchitis | Read by QxMDMost recent papers with the keyword antibiotic bronchitis | Read by QxMD
BACKGROUND: In February, 2017, the US Food and Drug Administration approved the blood infection marker procalcitonin for guiding antibiotic therapy in patients with acute respiratory infections. This meta-analysis of patient data from 26 randomised controlled trials was designed to assess safety of procalcitonin-guided treatment in patients with acute respiratory infections from different clinical settings. METHODS: Based on a prespecified Cochrane protocol, we did a systematic literature search on the Cochrane Central Register of Controlled Trials, MEDLINE, and Embase, and pooled individual patient data from trials in which patients with respiratory infections were randomly assigned to receive antibiotics based on procalcitonin concentrations (procalcitonin-guided group) or control ...
https://www.readbyqxmd.com/keyword/63203
Procalcitonin as a prognostic marker for sepsis: a prospective observational study.Procalcitonin as a prognostic marker for sepsis: a prospective observational study.
BACKGROUND: Procalcitonin is useful for the diagnosis of sepsis but its prognostic value regarding mortality is unclear. This prospective observational study was designed to study the prognostic value of procalcitonin in prediction of 28 day mortality in patients of sepsis. Fifty-four consecutive patients of sepsis, severe sepsis and septic shock defined using the 2001 Consensus Conference SCCM/ESICM/ACCP/ATS/SIS criteria from medical Intensive Care Unit (ICU) of a tertiary care center in New Delhi, India were enrolled from July 2011 to June 2013. Procalcitonin (PCT), C-reactive protein (CRP) measurements were recorded on day 1, day 7 and day 28 of follow up ...
http://beckerinfo.net/JClub/2015/04/22/procalcitonin-as-a-prognostic-marker-for-sepsis-a-prospective-observational-study/
Search Results | ECSearch Results | EC
Calcitonin-secreting neuroendocrine neoplasms of the lung are rare, with few cases reported in the literature. Differentiating between medullary thyroid carcinoma and an ectopic source of calcitonin secretion can represent a complex diagnostic conundrum for managing physicians, with cases of unnecessary thyroidectomy reported in the literature. This manuscript reports a case of ectopic hypercalcitonaemia from a metastatic neuroendocrine neoplasm of the lung with concurrent thyroid pathology and summarises the results of a systematic review of the literature. Medical Literature Analysis and Retrieval System Online, Excerpta Medica, Cochrane Central Register of Controlled Trials, ClinicalTrials.gov and SCOPUS databases were systematically and critically appraised for all peer reviewed manuscripts that suitably fulfilled the inclusion criteria established a priori. The protocol for this systematic review was developed according to the Preferred Reporting Items for Systematic review and ...
https://ec.bioscientifica.com/search?f_0=author&q_0=Eftychia+E+Drakou
Diagnostic value of procalcitonin and presepsin for sepsis in critically ill adult patients: A systematic review and meta...Diagnostic value of procalcitonin and presepsin for sepsis in critically ill adult patients: A systematic review and meta...
TY - JOUR. T1 - Diagnostic value of procalcitonin and presepsin for sepsis in critically ill adult patients. T2 - A systematic review and meta-analysis. AU - Kondo, Yutaka. AU - Umemura, Yutaka. AU - Hayashida, Kei. AU - Hara, Yoshitaka. AU - Aihara, Morio. AU - Yamakawa, Kazuma. PY - 2019/4/15. Y1 - 2019/4/15. N2 - Background: Early and accurate diagnosis of sepsis is challenging. Although procalcitonin and presepsin have been identified as potential biomarkers to differentiate between sepsis and other non-infectious causes of systemic inflammation, the diagnostic accuracy of these biomarkers remains controversial. Herein, we performed a comprehensive meta-analysis to assess the overall diagnostic value of procalcitonin and presepsin for the diagnosis of sepsis. Methods: We searched three electronic databases (MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials) for relevant studies. Two authors independently screened articles on the basis of inclusion and exclusion ...
https://pure.fujita-hu.ac.jp/ja/publications/diagnostic-value-of-procalcitonin-and-presepsin-for-sepsis-in-cri
Does serum procalcitonin have a diagnostic value in febrile adult patients presenting to the emergency department? | Critical...Does serum procalcitonin have a diagnostic value in febrile adult patients presenting to the emergency department? | Critical...
Pierre Hausfater and Bruno Riou. We thank van Oers and colleagues for their comments. We agree that likelihood ratios (LR) are useful tests in interpretation of clinical findings, laboratory tests, and image studies, although they are little used [3]. However, we do not think that LR is the unique response to a complex issue. First, LR is provided for a given predetermined threshold and we are convinced that the threshold of procalcitonin (PCT) highly depends on the population tested and the type of infection studied. Moreover, we recently observed that this threshold is markedly modified by renal function [4]. It should also be pointed out that the threshold is usually provided without confidence interval whereas this information might be very important [5]. In contrast, the receiver operating curve (ROC) provides a global assessment of diagnostic accuracy without any focus on a given threshold. Second, we do not think that the LR of PCT should be applied to the global population tested and ...
https://ccforum.biomedcentral.com/articles/10.1186/cc6172
News - B·R·A·H·M·S PCT (Procalcitonin)News - B·R·A·H·M·S PCT (Procalcitonin)
Thermo Fisher Scientific Inc. has received clearance from the U.S. Food and Drug Administration (FDA) that expands the clinical claims of the Thermo Scientific B·R·A·H·M·S PCT (Procalcitonin) biomarker assay for sepsis risk assessment. Clinicians can now use B·R·A·H·M·S PCT to help assess the response of septic patients to treatment by comparing a baseline PCT measurement with a PCT value taken on day four.. B·R·A·H·M·S PCT cleared for assessing mortality risk of septic patients ›. ...
https://www.procalcitonin.com/media-downloads/news.html
SciELO - Brazil - Identification of occult metastases of medullary thyroid carcinoma by calcitonin measurement in washout...SciELO - Brazil - Identification of occult metastases of medullary thyroid carcinoma by calcitonin measurement in washout...
CLINICAL CASE REPORT Identification of occult metastases of medullary thyroid carcinoma by calcitonin measurement in washout fluid from fine needle aspiration of cervical lymph node Identificação de metástase oculta do carcinoma medular de tireoide através da dosagem de calcitonina no lavado da agulha de punção aspirativa de linfonodo cervical Debora Siqueira; Andreia Possati Rocha; Marcia Khaled Puñales; Ana Luiza Maia Thyroid Section, Endocrine Division, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil Correspondence to ABSTRACT Medullary thyroid carcinoma (MTC) may occur sporadically or as a manifestation of an autosomal-dominant inherited syndrome, the multiple endocrine neoplasia type 2. DNA-based RET genotype analysis gained worldwide acceptance in the identification of asymptomatic gene carrier. MTC synthesize and secrete calcitonin, a well established tumor marker and postoperative level of serum calcitonin, indicates ...
https://www.scielo.br/j/abem/a/TphQcZDs4FLffpghHcdxCYs/?lang=en
Effects of eel calcitonin on rheumatoid arthritis. | Annals of the Rheumatic DiseasesEffects of eel calcitonin on rheumatoid arthritis. | Annals of the Rheumatic Diseases
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Centers RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.. ...
http://ard.bmj.com/content/50/3/202.2
Calcitonin receptor AluI (rs1801197) and TaqI calcitonin genes polymorphism in 45-and over 45-year-old women and their...Calcitonin receptor AluI (rs1801197) and TaqI calcitonin genes polymorphism in 45-and over 45-year-old women and their...
Purpose: Calcitonin receptor gene has also a polymorphism which is associated with bone mass density. This study evaluates the association between calcitonin receptor AluI (rs1801197) and Taq1 calcitonin genes polymorphism with bone density rate. Methods: In this descriptive-analytical study in 2013 in southwestern Iran, 200 blood samples, per the Cochran sample size formula, were taken from women aged 45 and older. DNA was extracted from the samples using the phenol- chloroform method and the genomic fragments in question were proliferated using the polymerase chain reaction (PCR) method. Results: The genotypic distribution of polymorphism AluI for TT, TC, and CC genotypes in control group was 31.4%, 38.6%, and 30% and in patients 25.4%, 55.4%, and 19.2%, respectively. There was no significant difference in polymorphism AluI between patients and control group and no significant association was found between this gene and bone density rate (P , 0.05). All patients and the individuals in the ...
http://eprints.skums.ac.ir/936/
THE POSSIBLE MEDIATION BY CYCLIC AMP OF THE STIMULATION OF THYMOCYTE PROLIFERATION BY VASOPRESSIN AND THE INHIBITION OF THIS...
Lysine vasopressin (antidiuretic hormone), like cyclic adenosine 3,5-monophosphate (cyclic AMP), rapidly (in less than 1 hour) stimulates the initiation of deoxyribonucleic acid synthesis and thereby increases the flow of cells into mitosis in rat thymic lymphocyte populations in vitro. This mitogenic action of vasopressin, again like that of cyclic AMP, is potentiated by caffeine, an inhibitor of the intracellular phosphodiesterase which catalyzes the degradation of cyclic AMP. On the other hand, vasopressins mitogenic action (also like that of cyclic AMP) is blocked by imidazole, an activator of cyclic nucleotide phosphodiesterase activity. The hormone, thyrocalcitonin (calcitonin) which is known to block the cyclic AMP-mediated mitogenic effect of parathyroid hormone by interfering with cyclic AMP action, also blocks the mitogenic action of vasopressin. The inhibitory effects of imidazole and thyrocalcitonin on vasopressins mitogenic action are both overcome by the phosphodiesterase inhibitor
http://oai.dtic.mil/oai/oai?verb=getRecord&metadataPrefix=html&identifier=AD0712179
Calcitonin measurement in pediatrics: reference ranges are gender-dependent, validation in medullary thyroid cancer and thyroid...Calcitonin measurement in pediatrics: reference ranges are gender-dependent, validation in medullary thyroid cancer and thyroid...
A summary of the article is shown below:. BACKGROUND: There is only limited information on serum reference ranges of calcitonin (CT) in infants, children and adolescents. This gap hampers valid diagnostics in patients with multiple endocrine neoplasia type 2 (MEN 2) and planned prophylactic thyroidectomy. In addition, age-dependent reference ranges for CT are necessary to define a cure in medullary thyroid carcinoma (MTC). We asked whether the reference ranges for CT levels were age- and gender-dependent in the serum of a pediatric cohort.METHODS: A total of 6090 serum samples of 2639 subjects of the LIFE-Child cohort aged between 1 month and 17.9 years were analyzed by the CT electrochemiluminescence immunoassay (ECLIA). Reference intervals were estimated using the LMS method. For clinical validation the serum of 28 patients (61 samples) with MEN 2 and 106 patients (136 samples) with thyroid diseases were analyzed.RESULTS: CT levels showed a clear age- and gender-dependence with significantly ...
https://moleculardepot.com/2019/08/31/calcitonin-measurement-in-pediatrics-reference-ranges-are-gender-dependent-validation-in-medullary-thyroid-cancer-and-thyroid-diseases/
Effects of pertussis toxin on adenylate cyclase responses to prostaglandin E2 and calcitonin in human breast cancer cells |...Effects of pertussis toxin on adenylate cyclase responses to prostaglandin E2 and calcitonin in human breast cancer cells |...
Both calcitonin and prostaglandin E2 (PGE2) stimulate adenylate cyclase activity in the human breast cancer cell line (T 47D). The maximum cyclic AMP response to calcitonin exceeds that of PGE2. When maximal concentrations of the two hormones were added simultaneously to the cells, the amount of cyclic AMP generated was less than that seen with calcitonin alone. When cells were treated with the protein toxin of Bordetella pertussis (islet-activating protein; IAP) which inactivates the inhibitory regulatory component (Ni) of adenylate cyclase, there was no change in basal or calcitonin-responsive adenylate cyclase in intact cells. However, the PGE2 response was augmented at all dose levels, and this effect was dependent on the concentration of IAP. Moreover, in cells pretreated with IAP, simultaneous addition of PGE2 and calcitonin resulted in additivity rather than in inhibition of cyclic AMP production. The additivity of the response to calcitonin and PGE2 after IAP treatment implies activation ...
http://www.biochemj.org/content/224/2/371
Plus itPlus it
Calcimimetic compounds, which activate the parathyroid cell Ca2+ receptor (CaR) and inhibit parathyroid hormone (PTH) secretion, are under experimental study as a treatment for hyperparathyroidism. This report describes the salient pharmacodynamic properties, using several test systems, of a new calcimimetic compound, cinacalcet HCl. Cinacalcet HCl increased the concentration of cytoplasmic Ca2+ ([Ca2+]i) in human embryonic kidney 293 cells expressing the human parathyroid CaR. Cinacalcet HCl (EC50 = 51 nM) in the presence of 0.5 mM extracellular Ca2+ elicited increases in [Ca2+]i in a dose- and calcium-dependent manner. Similarly, in the presence of 0.5 mM extracellular Ca2+, cinacalcet HCl (IC50 = 28 nM) produced a concentration-dependent decrease in PTH secretion from cultured bovine parathyroid cells. Using rat medullary thyroid carcinoma 6-23 cells expressing the CaR, cinacalcet HCl (EC50 = 34 nM) produced a concentration-dependent increase in calcitonin secretion. In vivo studies in rats ...
http://jpet.aspetjournals.org/content/308/2/627
Elcatonin - AR10226PU-L | acris-antibodies.com
Elcatonin, 0.1 g. |p class=db_paraghraph|Elcatonin is a Calcitonin derivative which is transformed from eels calcitonin by changing the S-S bond into the stable C-N bond.
https://www.acris-antibodies.com/proteins-growth-factors/elcatonin-ar10226pu-l.htm
The Role of the Procalcitonin in Diagnosis of Neonatal Sepsis and Correlation Between Procalcitonin and C-Reactive Protein in...The Role of the Procalcitonin in Diagnosis of Neonatal Sepsis and Correlation Between Procalcitonin and C-Reactive Protein in...
Abstract: The goal of this study was to investigate the role of procalcitonin (PCT) in diagnosis of neonatal sepsis and its correlation with C-Reactive Protein (CRP). One hundred and seventeen neonates with the gestational age ≥35 weeks with clinically suspected diagnosis of neonatal sepsis were studied during one year from 2007 in Tabriz Children`s Hospital. Conventional sepsis workup was done in all cases and the diagnosis of neonatal sepsis was proved based on the results of blood culture. The serum procalcitonin was measured by quantitative Chemo-luminance methods and the results were compared with CRP levels between the neonates with and without proven sepsis. The results showed among in 117 neonates with suspected sepsis 27 (23.1%) cases have positive blood culture (proven sepsis). The mean levels of PCT in neonates with and without proven sepsis was 4.42 ±6.66 vs. 2.06 ±4.03 ng mL-1 and CRP 33.98 ±36.81 vs. 12.30 ±20.42 mg L-1 were significantly higher in neonates with proven sepsis ...
https://scialert.net/asci/ascidetail.php?doi=pjbs.2008.1785.1790&kw=C-reactive%20protein
Rapports 2012 | LUnité dévaluation des technologies du CUSM - McGill UniversityRapports 2012 | LUnité dévaluation des technologies du CUSM - McGill University
DROTRECOGIN ALFA [.pdf] Drotrecogin Alfa(Activated) in Severe Sepsis (Report #58) DERMAL MATRIX [.pdf] Evaluation of acellular dermal matrix for breast reconstruction: An Update(Report #59) VIDEO CAPSULE ENDOSCOPY [.pdf] Video capsule endoscopy for obscure GI bleeding and Crohns Disease (Update of Report 7).(Report #60) KTP [.pdf] 532 nm KTP Laser for vocal fold (Report #61) PROCALCITONIN [.pdf] Use of serum procalcitonin levels in treatment decisions for adult patients in the Intensive Care Unit.(Report #62) INTRABEAM [.pdf] Single-dose Intraoperative Radiotherapy Using Intrabeam® for Early-stage Breast cancer: A Health Technology Assessment.(Report #63) TAU IMPACT REPORT [.pdf] The Impact of Reports of The Technology Assessment Unit of the McGill University Health Centre.(Report #65) HYBRID OPERATING ROOM [.pdf] The Hybrid Operating Room. Should one be available for Cardiovascular-Thoracic procedures in the MUHC? A brief report. (Report #67) BALLOON SINUPLASTY [.pdf] Balloon Catheter Dilation for
http://www.mcgill.ca/tau/fr/publications/2012
Do Procalcitonin Levels Help Guide Antibiotic Therapy in Acute Exacerbation of Chronic Obstructive Airway Disease? - Chackos...Do Procalcitonin Levels Help Guide Antibiotic Therapy in Acute Exacerbation of Chronic Obstructive Airway Disease? - Chackos...
There has been a growing interest regarding the utility of procalcitonin to guide appropriate initiation and duration of antibiotic therapy in critically ill patients. Two randomized controlled studies in critically ill patients suspected to have bacterial infections arrived at disparate conclusions (De Jong et al. 2016; Bouadma et al. 2010). In patients presenting with…
https://criticalcareblogspot.com/2018/11/23/do-procalcitonin-levels-help-guide-antibiotic-therapy-in-acute-exacerbation-of-chronic-obstructive-airway-disease/
Kadar Procalcitonin sebagai marker dan hubungannya dengan derajat keparahan sepsis.Kadar Procalcitonin sebagai marker dan hubungannya dengan derajat keparahan sepsis.
Background : The mortality on sepsis is still high. Its because of delayed ofthe treatment resulted from the diagnosis of sepsis estabilished more frequently imprecise. The inflammatory makers as c reactive protein and leucocyte apparently have high sensitivity and specifity where do contemn whereas blood culture examination required so long time and the result of culture often negatively. Research on Procalcitonin (PCT) formering have important of the role for the establishment diagnosis of sepsis because its utilized as sepsis marker and in reference to severity sepsisdegree . Objective: To determine whether procalcitonin can be used as sepsis marker and severity of sepsis. Method : Patients were assigned as 2 groups, sepsis and without sepsis with their consisting of 21 samples respectively. In the sepsis subgroup separated as sepsis only (8 samples), severe sepsis (6 samples) and sepsis shock (7 samples). All of them were examined by procalcitonin, C reactive protein, blood culture and ...
http://repository.usu.ac.id/handle/123456789/34848
Calcitonin (salmon) - Creative PeptidesCalcitonin (salmon) - Creative Peptides
Calcitonin (salmon) is a 32-amino acid polypeptide hormone that is produced in humans primarily by the parafollicular cells (also known as C-cells) of the thyroid, and in many other animals in the ultimobranchial body. It acts to reduce blood calcium (Ca2+), opposing the effects of parathyroid hormone (PTH). The calcitonin receptor has been cloned and shown to be a member of the seven-transmembrane, G protein-coupled receptor family.
https://www.creative-peptides.com/product/calcitonin-salmon-item-10-101-08-23.html
Risks and Benefits of Long-term Use of Calcitonin - Shared by Casey Chan - WizFolio
|h2>|span class=Apple-style-span style=font-weight: normal; font-family: arial; font-size: medium;>|img src=http://upload.wikimedia.org/wikipedia/commons/thumb/3/34/Illu_compact_spongy_bone.jpg/347px-Illu_compact_spongy_bone.jpg alt= align=none>|span class=Apple-style-span style=font-family: Verdana; font-size: 12px; >|img src=http://upload.wikimedia.org/wikipedia/commons/thumb/b/bc/Spongy_bone_-_trabecules.jpg/350px-Spongy_bone_-_trabecules.jpg alt= align=none>|/span>|/span>|/h2>|div>|span class=Apple-style-span style=font-size: x-small;>Picture source: Wikipedia|/span>|/div>|h2>|span class=Apple-style-span style=font-weight: normal; font-family: arial; font-size: medium; >Calcitonin is a polypeptide hormone that participates in calcium and phosphorous metabolism. It controls calcium level in the blood by opposing the effect of the parathyroid hormone through its actions on osteoclasts. Salmon calcitonin is the form of calcitonin used clinically. The two major advantages
http://profiles.wizfolio.com/caseychan/collections/271/166676/
IHCPlus™ CALCR / Calcitonin Receptor Polyclonal Antibody Rabbit | LSBioIHCPlus™ CALCR / Calcitonin Receptor Polyclonal Antibody Rabbit | LSBio
IHCPlus™ CALCR / Calcitonin Receptor Antibody LS-A769 is a pathologist validated IHC antibody Rabbit anti-Human CALCR / Calcitonin Receptor. Validated for IHC. Tested on 20 paraffin-embedded human tissues.
https://www.lsbio.com/antibodies/ihc-plus-calcr-antibody-calcitonin-receptor-antibody-transmembrane-domain-ihc-ls-a769/1974
Browse our Calcitonin Receptor ELISA KitsBrowse our Calcitonin Receptor ELISA Kits
Order Calcitonin Receptor ELISA Kits for many Reactivities. Chicken, Guinea Pig, Human and more. Compare Calcitonin Receptor ELISA Kits and find the right product on antibodies-online.com.
http://www.antibodies-online.com/camp-metabolic-process-pathway-59/calcitonin-receptor-elisa-kit-596/
Cloning and characterization of a mouse brain calcitonin receptor complementary deoxyribonucleic acid and mapping of the...Cloning and characterization of a mouse brain calcitonin receptor complementary deoxyribonucleic acid and mapping of the...
Fingerprint Dive into the research topics of Cloning and characterization of a mouse brain calcitonin receptor complementary deoxyribonucleic acid and mapping of the calcitonin receptor gene. Together they form a unique fingerprint. ...
https://scholars.houstonmethodist.org/en/publications/cloning-and-characterization-of-a-mouse-brain-calcitonin-receptor-2/fingerprints/
Late immunoneutralization of procalcitonin arrest the progression of lethal porcine sepsis<...
TY - JOUR. T1 - Late immunoneutralization of procalcitonin arrest the progression of lethal porcine sepsis. AU - Martinez, Jose M.. AU - Wagner, Kristin E.. AU - Snider, Richard H.. AU - Nylen, Eric S.. AU - Muller, Beat. AU - Sarani, Babak. AU - Becker, Kenneth L.. AU - White, Jon C.. PY - 2001/9/1. Y1 - 2001/9/1. N2 - Background: Procalcitonin (ProCT) is becoming increasingly recognized as a mediator as well as a marker of sepsis. Serum ProCT concentrations rise soon after induction of sepsis and remain elevated over a prolonged period of time. In contrast, many pro-inflammatory cytokines, e.g., tumor necrosis factor alpha (TNF-α) and interleukin-1 beta (IL-1β), rise and decline early in the course of sepsis. Researchers have improved survival in animal models of sepsis by prophylactically blocking IL-1β and TNF-α with immunotherapy, but therapeutic treatment has been less successful in clinical trials. We hypothesized that the sustained elevation of ProCT in the serum would allow for ...
https://miami.pure.elsevier.com/en/publications/late-immunoneutralization-of-procalcitonin-arrest-the-progression
Procalcitonin is an independent predictor for coronary atherosclerotic burden in patients with stable coronary artery disease |...Procalcitonin is an independent predictor for coronary atherosclerotic burden in patients with stable coronary artery disease |...
Objectives: Higher coronary atherosclerotic burden has been associated with increased cardiovascular events including mortality. The SYNTAX score (SXs) reflects coronary atherosclerotic burden. Given the body of evidence implicating inflammation in atherosclerotic process, we hypothesized that procalcitonin (PCT) as an inflammatory marker may be related to coronary atherosclerotic burden. Thus, we aimed to investigate the relationship between serum PCT levels and SXs in patients with stable CAD. ...
https://avesis.erciyes.edu.tr/yayin/1eb61f93-ea7a-4ffb-91ac-2cbb5516067f/procalcitonin-is-an-independent-predictor-for-coronary-atherosclerotic-burden-in-patients-with-stable-coronary-artery-disease
Calcitonin Gene Related Peptide (CGRP) - Pipeline Review, H2 2019 - Global Markets DirectsCalcitonin Gene Related Peptide (CGRP) - Pipeline Review, H2 2019 - Global Markets Directs
Global Markets Directs, Calcitonin Gene Related Peptide (CGRP) - Pipeline Review, H2 2018, provides in depth analysis on Calcitonin Gene
https://www.globalmarketsdirect.com/report/gmdhc2019tdb--calcitonin-gene-related-peptide-cgrp-pipeline-review-h2-2019/
Procalcitonin levels predict bacteremia in patients with community-acquired pneumonia : a prospective cohort trial - edocProcalcitonin levels predict bacteremia in patients with community-acquired pneumonia : a prospective cohort trial - edoc
Guidelines recommend blood culture sampling from hospitalized patients with suspected community-acquired pneumonia (CAP). However, the yield of true-positive results is low. We investigated the benefit of procalcitonin (PCT) on hospital admission to predict blood culture positivity in CAP ...
https://edoc.unibas.ch/27899/
CGRP elisa kit | Fish Calcitonin Gene Related Peptide ELISA Kit-NP 001095943.1CGRP elisa kit | Fish Calcitonin Gene Related Peptide ELISA Kit-NP 001095943.1
Buy CGRP elisa kit, Fish Calcitonin Gene Related Peptide ELISA Kit-NP_001095943.1 (MBS029789) product datasheet at MyBioSource, ELISA Kits
https://www.mybiosource.com/prods/ELISA-Kit/Fish/Calcitonin-Gene-Related-Peptide/CGRP/datasheet.php?products_id=29789
Calcitonin Gene Related Peptide : Severn Biotech, Limited
Severn Biotech, Limited : Calcitonin Gene Related Peptide - Electrophoresis Products PBS & Saline Solutions Hybridisation Reagents Biological Buffers & SDS Sodium Azide Solutions General Bio-chemical Products Fingerprinting Chemical Product Forensic Dyes & Chemicals HPLC Laboratory Solvents DNA / RNA Extraction Specialist Pure Water Products Protein Linker Conjugates Peptide Synthesis Reagents Alcohol Sprays Hand Sanitiser Products Customised Services Comet Assay Products Protein Antibody Reagents Scientific Plastics Catalogue Peptides Affinity Purification Materials Cytology Screening Antibodies Specials severn, biotech
http://www.severnbiotech.com/index.php?main_page=index&cPath=109_126
TumorPortal
This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin by tissue-specific alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins. Calcitonin is involved in calcium regulation and acts to regulate phosphorus metabolism. Calcitonin gene-related peptide functions as a vasodilator while katacalcin is a calcium-lowering peptide. Multiple transcript variants encoding different isoforms have been found for this gene ...
http://www.tumorportal.org/view?geneSymbol=CALCA
Health Article |Endocrinology | University Hospitals Cleveland Medical Center | Cleveland, OHHealth Article |Endocrinology | University Hospitals Cleveland Medical Center | Cleveland, OH
The thyroid gland is located in the front of the neck. It sits below the voice box (larynx). The small, two-inch gland consists of two lobes, one on each side of the windpipe, connected by a small bridge of thyroid tissue called the isthmus.. The thyroid tissue is made up of two types of cells: follicular cells and parafollicular cells. Most of the thyroid tissue consists of the follicular cells, which secrete the iodine-containing thyroid hormones. They consist of thyroxine (T4) and triiodothyronine (T3). The parafollicular cells secrete the hormone calcitonin. In humans, calcitonin has only a minor role in calcium regulation.. ...
http://www.uhhospitals.org/cleveland/services/endocrinology/health-library/health-article?contentTypeId=85&contentId=P00432
EMEA (Europe, Middle East and Africa) Procalcitonin (CAS 56645-65-9) Market 2017 Forecast to 2022 : ReportsnReports
[116 Pages Report] Check for Discount on EMEA (Europe, Middle East and Africa) Procalcitonin (CAS 56645-65-9) Market 2017 Forecast to 2022 report by Global Info Research. Procalcitonin (PCT) is a 116 amino acid residue protein with...
http://www.reportsnreports.com/reports/1254049-emea-europe-middle-east-and-africa-procalcitonin-cas-56645-65-9-market-2017-forecast-to-2022.html
View source for Procalcitonin - WikEMView source for Procalcitonin - WikEM
Background== Serum biomarker that may help distinguish between bacterial infection and other causes of infection or inflammation. ==Use== Differentiate lower respiratory inflammation/infection into bacterial vs. other etiology, and help clinicians choose if antibiotics are appropriate. ==Evidence== *In patients with lower respiratory tract infections, procalcitonin guided antibiotic stewardship didnt result in worse outcomes, but did reduce antibiotic exposure and their associated effects ,ref>Schuetz, P., Christ-Crain, M., Thomann, R., Falconnier, C., Wolbers, M., Widmer, I., … ProHOSP Study Group. (2009). Effect of procalcitonin-based guidelines vs standard guidelines on antibiotic use in lower respiratory tract infections: the ProHOSP randomized controlled trial. JAMA: The Journal of the American Medical Association, 302(10), 1059-1066.,/ref> *Procalcitonin-guided approach to inform antibiotic therapy didnt result in decreased antibiotic use compared to usual care ,ref>Huang, D. T., ...
https://wikem.org/w/index.php?title=Procalcitonin&action=edit
NewYork-Presbyterian Queens - The Thyroid Gland
The thyroid gland is located in the front of the neck, below the larynx (voice box). The small, two-inch gland consists of two lobes, one on each side of the windpipe, connected by tissue called the isthmus.. The thyroid tissue is made up of two types of cells: follicular cells and parafollicular cells. Most of the thyroid tissue consists of the follicular cells, which secrete iodine-containing hormones called thyroxine (T4) and triiodothyronine (T3). The parafollicular cells (also called C cells) secrete the hormone calcitonin. The thyroid requires iodine to produce the hormones.. ...
http://www.nyhq.org/diw/Content.asp?PageID=DIW000432&More=WTN&language=Korean
Procalcitonin-guided diagnosis and antibiotic stewardship revisited | BMC Medicine | Full TextProcalcitonin-guided diagnosis and antibiotic stewardship revisited | BMC Medicine | Full Text
Several controlled clinical studies have evaluated the potential of the infection biomarker procalcitonin (PCT) to improve the diagnostic work-up of patients with bacterial infections and its influence on decisions regarding antibiotic therapy. Most research has focused on lower respiratory tract infections and critically ill sepsis patients. A clinical utility for PCT has also been found for patients with urinary tract infections, postoperative infections, meningitis, and patients with acute heart failure with possible superinfection (i.e., pneumonia). In these indications, PCT levels measured on hospital admission were found to substantially reduce the initiation of antibiotic treatment in low-risk situations (i.e., bronchitis, chronic obstructive pulmonary disease exacerbation). For more severe infections (i.e., pneumonia, sepsis), antibiotic stewardship by monitoring of PCT kinetics resulted in shorter antibiotic treatment durations with early cessation of therapy. Importantly, these strategies
https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-017-0795-7/tables/1
Anatomy of the thyroid gland - VCU Massey Cancer CenterAnatomy of the thyroid gland - VCU Massey Cancer Center
The thyroid gland is located in the front of the neck, below the larynx (voice box). The small, two-inch gland consists of two lobes, one on each side of the windpipe, connected by tissue called the isthmus.. The thyroid tissue is made up of two types of cells: follicular cells and parafollicular cells. Most of the thyroid tissue consists of the follicular cells, which secrete iodine-containing hormones called thyroxine (T4) and triiodothyronine (T3). The parafollicular cells secrete the hormone calcitonin. The thyroid needs iodine to produce the hormones ...
https://ts.vcu.edu/cgi-bin/posh.pl?posh_referer=https%3A%2F%2Fwww.massey.vcu.edu%2Fcancer%2Fthyroid-tumors%2Fanatomy%2F
Intensive Care Medicine: AbstractIntensive Care Medicine: Abstract
Compared to those with bacterial or mixed infection (n = 9), patients with 2009 H1N1 infection (n = 16) were significantly more likely to have bilateral chest X-ray infiltrates, lower APACHE scores, more prolonged lengths of stay in ICU and lower white cell count, procalcitonin and CRP levels. Using a cutoff of ,0.8 ng/ml, the sensitivity and specificity of procalcitonin for detection of patients with bacterial/mixed infection were 100 and 62%, respectively. A CRP cutoff of ,200 mg/l best identified patients with bacterial/mixed infection (sensitivity 100%, specificity 87.5%). In combination, procalcitonin levels ,0.8 ng/ml and CRP ,200 mg/l had optimal sensitivity (100%), specificity (94%), negative predictive value (100%) and positive predictive value (90%). Receiver-operating characteristic curve analysis suggested the diagnostic accuracy of procalcitonin may be inferior to CRP in this setting.. ...
http://icmjournal.esicm.org/Journals/abstract.html?doi=10.1007/s00134-009-1746-3
MRNA expression of 5-hydroxytryptamine 1B, 1D, and 1F receptors and their role in controlling the release of calcitonin gene...
TY - JOUR. T1 - MRNA expression of 5-hydroxytryptamine 1B, 1D, and 1F receptors and their role in controlling the release of calcitonin gene-related peptide in the rat trigeminovascular system. AU - Amrutkar, Dipak V.. AU - Ploug, Kenneth B.. AU - Hay-Schmidt, Anders. AU - Porreca, Frank. AU - Olesen, Jes. AU - Jansen-Olesen, Inger. N1 - Funding Information: This study was supported by Candys Foundation , The Lundbeck Foundation , The Lundbeck Foundation as part of the Lundbeck Foundation Center for Neurovascular Signaling (LUCENS), and by the Aase and Ejnar Danielsen Foundation and the A.P. Møller Foundation for the advancement of Medical Sciences.. PY - 2012/4. Y1 - 2012/4. N2 - Triptans, a family of 5-hydroxytryptamine (5-HT) 1B, 1D, and 1F receptor agonists, are used in the acute treatment of migraine attacks. The site of action and subtypes of the 5-HT 1 receptor that mediate the antimigraine effect have still to be identified. This study investigated the mRNA expression of these ...
https://arizona.pure.elsevier.com/en/publications/mrna-expression-of-5-hydroxytryptamine-1b-1d-and-1f-receptors-and
When Profiling Is a Good Thing: Distinguishing Bacterial from Viral Infection | 2015-07-20 | AHC Media: Continuing Medical...When Profiling Is a Good Thing: Distinguishing Bacterial from Viral Infection | 2015-07-20 | AHC Media: Continuing Medical...
By Joseph F. John, Jr., MD, FACP, FIDSA, FSHEA Dr. John is Clinical Professor of Medicine, Medical University of South Carolina, Charleston. Dr. John reports no financial relationships relevant to this field of study. SYNOPSIS: Transcriptional analysis outperformed serum procalcitonin in distinguishing viral from bacterial infections. SOURCE: Suarez NM, Bunsow E, Falsey AR, et al. Superiority of transcriptional profiling over procalcitonin for distinguishing bacterial from viral lower respiratory tract infections in hospitalized adults. J Infect Dis 2015;212:213-222. Procalcitonin predicts, to a degree, the likelihood of . . .
https://www.reliasmedia.com/articles/135954-when-profiling-is-a-good-thing-distinguishing-bacterial-from-viral-infection
How long does it take for benazepril to take effect
8mmol/L, aCE somatostatin analogues to four-fold increase in the production. Consequently, cannot tolerate caber- goline and lH, even if a particular in isolation Moreover, rashes. There were formerly believed to what does promethazine and codeine do can you take nyquil with meloxicam the bMJ previously received streptokinase how long does it take for benazepril to take effect Combination therapy. The fusion rather than glibenclamide, and persistence of bronchospasm. For example, the gastro- intestinal elec- trolyte transport. Side effects, but its use in which patients who are recombinant salmon calcitonin Severe overdose, tIBC. The lipophilic surface of limited by free acid from the renin-angiotensin system. Side effects, but its use in which patients who are recombinant salmon calcitonin. Progressive visual disturbances, lidocaine and in her prognosis It acts as well tolerated. Doctors are non- pathogenic to the broad spectrum and their mechanism. For rectosigmoid disease constipation and ...
http://imagenenaccion.org/how-long-does-it-take-for-benazepril-to-take-effect
Does the thyroid gland stop releasing calcitonin if you have hyperparathyroidism? | Yahoo AnswersDoes the thyroid gland stop releasing calcitonin if you have hyperparathyroidism? | Yahoo Answers
Calcitonin is supposed to stop the secretion of calcium, but if you have hyperparathyroidism and the body cannot stop pushing out calcium, what happens to the calcitonin? My classmate hypothesized it just is not enough to get rid of all of it, but i dont feel like that is it exactly.
https://uk.answers.yahoo.com/question/index?qid=20191114200248AA9lvZH
calcitonin salmon recombinant: Pharmaceutical manufacturers, suppliers, and distributorscalcitonin salmon recombinant: Pharmaceutical manufacturers, suppliers, and distributors
Generic CALCITONIN SALMON RECOMBINANT availability. Has a generic version of CALCITONIN SALMON RECOMBINANT been approved? Find suppliers, manufacturers, and packagers
https://www.drugpatentwatch.com/p/supplier/calcitonin+salmon+recombinant/i/
Reference Values in Sepsis - B·R·A·H·M·S PCT (Procalcitonin)Reference Values in Sepsis - B·R·A·H·M·S PCT (Procalcitonin)
After birth the PCT values of the newborn increase over the first 24 hours and stay elevated during the first 2-3 days of life. Therefore separate, well-defined reference ranges apply to new born infants at different hours of age during the first 48 hours of life (see Figure below). However, also during these first days of life, the PCT values of newborns suffering from early sepsis are significantly higher than those of non-infected newborns, so that PCT can be used for sepsis diagnosis. The adult reference range applies after day 3.. ...
https://www.procalcitonin.com/clinical-utilities/sepsis/reference-values-sepsis.html
Giamarellos-Bourboulis, E.J., Grecka, P., Poulakou, G., et al. (2001) Assessment of procalcitonin as a diagnostic marker of...Giamarellos-Bourboulis, E.J., Grecka, P., Poulakou, G., et al. (2001) Assessment of procalcitonin as a diagnostic marker of...
Giamarellos-Bourboulis, E.J., Grecka, P., Poulakou, G., et al. (2001) Assessment of procalcitonin as a diagnostic marker of underlying infection in patients with febrile neutropenia. Clinical Infectious Diseases, 32, 1718-1725. doi10.1086/320744
https://scirp.org/reference/referencespapers.aspx?referenceid=706986
Calcitonin Salmon Nasal Spray
Calcitonin salmon nasal spray is an osteoporosis drug that is approved for postmenopausal women. This eMedTV Web page explains how the nasal spray works and offers more information on its dosing, effects, and potential side effects.
http://senior-health.emedtv.com/calcitonin-salmon-nasal-spray/calcitonin-salmon-nasal-spray-p4.html
Most recent papers with the keyword VAP and antibiotic | Read by QxMDMost recent papers with the keyword VAP and antibiotic | Read by QxMD
The aim of this study was to evaluate the procalcitonin (PCT) changes in two different high-dose colistin regimens in the treatment of multi-drug resistant MDR gram negative infections in ICU patients. This is a prospective study of adult ICU patients with bacteremia and ventilator associated pneumonia (VAP) caused by MDR gram negative pathogens. Patients were assigned to two colistin administration groups. Group A received 9 and group B received 3 million international units every 24 and 8 h respectively. Baseline characteristics and measurements of PCT concentrations at the start, the 3rd and the 5th day of the antibiotic therapy and their trends between the two groups were recorded and compared ...
https://www.readbyqxmd.com/keyword/118319
subscribe cgrp genesubscribe cgrp gene
Dear sir: I am urgently need human beta calcitonin gene related peptide gene for my method. Please tell me where to get or buy the gene. Thanks Sincerely Huaichun Wang Institute of Medical Information 27 Taiping Road Beijing 100850 China Fax: 8610 8213044 ...
http://www.bio.net/bionet/mm/methods/1995-November/036252.html
Plus itPlus it
Results CRP levels of SLE patients with infections were higher than those with flares [5.9 mg/dl (IQR 2.42, 10.53) vs 0.06 mg/dl (IQR 0.03, 0.15), p , 0.001] and decreased after the infection was resolved. S100A8/A9 and procalcitonin levels of SLE patients with infection were also higher [4.69 μg/ml (IQR 2.25, 12.07) vs 1.07 (IQR 0.49, 3.05) (p , 0.001) and 0 ng/ml (IQR 0-0.38) vs 0 (0-0) (p , 0.001), respectively]; these levels were also reduced once the infection disappeared. In the receiver-operating characteristics analysis of CRP, S100A8/A9, and procalcitonin, the area under the curve was 0.966 (95% CI 0.925-1.007), 0.732 (95% CI 0.61-0.854), and 0.667 (95% CI 0.534-0.799), respectively. CRP indicated the presence of an infection with a sensitivity of 100% and a specificity of 90%, with a cutoff value of 1.35 mg/dl. ...
http://www.jrheum.org/content/early/2012/02/10/jrheum.111044
Excessive weight loss and fatigue - moscowtorex.ru
Initially, you are not concerned, maybe even you are pleased a little. However, unexplained weight loss and fatigue are snd of the commonest symptoms you will experience with a progressive illness. There are many possible causes of sudden weight loss and some olss which might be caused due to a serious illness. Here are 10 common conditions that cause unexplained weight loss. Thyroid gland also produces a hormone calcitonin that regulates the level of calcium in your blood. When the fatgiue gland produces too much thyroid hormone overactivethe condition is called hyperthyroidism.. However, not can i lose weight by sleeping a lot has all these symptoms. You may relate to just a few of them. You may fatigus to many of them, too. It mainly affects the lungs. Tuberculosis can also affect the kidneys, spine or brain. The disease can be treated with a six-month course of antibiotics. The airflow can be blocked by an inflammation of the lining of bronchial tubes that wieght air to and from weighf ...
http://moscowtorex.ru/excessive-weight-loss-and-fatigue.php
A Randomized, Double-Blind, Multiple Dose, Placebo-Controlled, Parallel Group, 48-Week, Study of Oral Recombinant Salmon...A Randomized, Double-Blind, Multiple Dose, Placebo-Controlled, Parallel Group, 48-Week, Study of Oral Recombinant Salmon...
This noninferiority trial assessed the efficacy and tolerability of oral recombinant salmon calcitonin compared with calcitonin nasal spray in postmenopausal
http://adisinsight.springer.com/trials/700048118?error=cookies_not_supported&code=cbc96d84-e0a2-4309-a780-cb0af678b180
Peptides from the calcitonin genes: molecular genetics, structure and function | Biochemical JournalPeptides from the calcitonin genes: molecular genetics, structure and function | Biochemical Journal
Thank you for your interest in spreading the word about Biochemical Journal.. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.. ...
http://www.biochemj.org/content/255/2/377
Postsurgical Follow-Up and Management | SpringerLinkPostsurgical Follow-Up and Management | SpringerLink
All patients with medullary thyroid carcinoma (MTC) should undergo calcitonin (CT) determination at regular intervals after total thyroidectomy. Within 6 weeks after operation serum CT measurement...
https://link.springer.com/chapter/10.1007/978-3-642-84749-3_10
Calcitonin gen-relateret protein - Wikipedia, den frie encyklopædiCalcitonin gen-relateret protein - Wikipedia, den frie encyklopædi
Både α-CGRP og β-CGRP er peptider på 37 aminosyrer. α-CGRP dannes ved en alternativ splejsning af genet for calcitonin beliggende på kromosom 11. Det mindre undersøgte β-CGRP afviger fra α-CGRP ved at være kodet i et separat gen i samme område og er kun forskellig i tre aminosyrer. Regulering af ekspressionen af CGRP kontrolleres igennem signaltransduktionen af cytokiner gennem mitogen-aktiverede proteinkinaser (MAPK). CGRP medierer sine effekter igennem en heteromer receptor, der består af en G-protein-koblet receptor benævnt CALCRL og et aktivitetsmodificerende protein (RAMP1). CGRP-receptorer findes i hele kroppen. ...
https://da.wikipedia.org/wiki/Calcitonin_gen-relateret_protein
Rev Esp Quimioter 2020; 33(1):32-43 - SEQRev Esp Quimioter 2020; 33(1):32-43 - SEQ
Results. A total of 1,425 blood cultures were finally enrolled in the study. Of those were considered true bacteremia 179 (12.6 %) and as negative blood cultures 1,246 (87.4 %). Amongst negatives, 1,130 (79.3%) without growth and 116 (8.1%) as contaminants blood cultures. Five variables were significantly associated with true bacteraemia: serum procalcitonin (PCT) ≥ 0.51 ng/ml [odds ratio (OR): 4.52; 95% confidence interval (CI): 4.20-4.84, P ,.001], temperature , 38.3°C [OR:1.60; 95% CI:1.29-1.90, P ,.001], systolic blood pressure (SBP) , 100 mmHg [OR:3.68; 95% CI:2.78-4.58, P ,.001], septic shock [OR:2.96; 95% CI:1.78-4.13, P ,.001] and malignancy [OR:1.73; 95% CI:1.27-2.20, P ,.001 ...
https://seq.es/abstract/rev-esp-quimioter-2019-november-29-2/
CalcitoninCalcitonin
Wikimedia Commons has media related to Calcitonin. The Calcitonin Protein Calcitonin at the US National Library of Medicine ... Calcitonin has clinically been used for metabolic bone disorders for more than 50 years. Salmon calcitonin is used for the ... Calcitonin also has significantly impacted molecular biology, as the gene encoding calcitonin was the first gene discovered in ... Calcitonin is secreted into the milk. Calcitonin was extracted from the ultimobranchial glands (thyroid-like glands) of fish, ...
https://en.wikipedia.org/wiki/Calcitonin
Calcitonin receptorCalcitonin receptor
The calcitonin receptor (CT) is a G protein-coupled receptor that binds the peptide hormone calcitonin and is involved in ... Pondel M (December 2000). "Calcitonin and calcitonin receptors: bone and beyond". International Journal of Experimental ... Nakamura M, Hashimoto T, Nakajima T, Ichii S, Furuyama J, Ishihara Y, Kakudo K (April 1995). "A new type of human calcitonin ... Calcitonin+receptors at the US National Library of Medicine Medical Subject Headings (MeSH) (Webarchive template wayback links ...
https://en.wikipedia.org/wiki/Calcitonin_receptor
Calcitonin gene-related peptideCalcitonin gene-related peptide
... (CGRP) is a member of the calcitonin family of peptides consisting of calcitonin, amylin, ... The mammalian calcitonin gene-related peptides, adrenomedullin, amylin, and calcitonin receptors". Pharmacological Reviews. 54 ... adrenomedullin, adrenomedullin 2 (intermedin) and calcitonin‑receptor‑stimulating peptide. Calcitonin is mainly produced by ... Regulation of the calcitonin gene-related peptide (CGRP) gene is in part controlled by the expression of the mitogen-activated ...
https://en.wikipedia.org/wiki/Calcitonin_gene-related_peptide
Calcitonin gene-related peptide receptor antagonistCalcitonin gene-related peptide receptor antagonist
Calcitonin gene-related peptide (CGRP) receptor antagonists are a class of drugs that act as antagonists of the calcitonin gene ... Nakasa, T; Ishikawa, M; Takada, T; Miyaki, S; Ochi, M (2015). "Attenuation of cartilage degeneration by calcitonin gene-related ... v t e (CS1 German-language sources (de), Antimigraine drugs, Receptor antagonists, Calcitonin gene-related peptide receptor ... Mitsikostas, DD; Reuter, U (2017). "Calcitonin gene-related peptide monoclonal antibodies for migraine prevention: comparisons ...
https://en.wikipedia.org/wiki/Calcitonin_gene-related_peptide_receptor_antagonist
Calcium cycleCalcium cycle
"Calcitonin , You and Your Hormones from the Society for Endocrinology". www.yourhormones.info. Retrieved 2018-10-04. "What's ... Excess calcium then promotes the release of calcitonin from the thyroid gland, effectively reversing the process of PTH. ...
https://en.wikipedia.org/wiki/Calcium_cycle
Receptor activity-modifying proteinReceptor activity-modifying protein
When associated with the Calcitonin receptor (CTR) or Calcitonin receptor-like (CALCRL) (below), RAMPs can change the ... "Calcitonin Receptors: Introduction". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical ... "Calcitonin Receptors". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. ... calcitonin (CT), glucagon, and vasoactive intestinal peptide (VIP). There are three distinct types of RAMPs in mammals (though ...
https://en.wikipedia.org/wiki/Receptor_activity-modifying_protein
RAMP1RAMP1
"Functional calcitonin gene-related peptide receptors are formed by the asymmetric assembly of a calcitonin receptor-like ... "Calcitonin Receptors: Introduction". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical ... "Calcitonin Receptors". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. ... The RAMP1 protein can also interact with the calcitonin receptor (CT) protein, where heteromerisation of RAMP1 with CT converts ...
https://en.wikipedia.org/wiki/RAMP1
Ultimopharyngeal bodyUltimopharyngeal body
These secrete calcitonin. In other animals, the ultimopharyngeal body may produce calcitonin. The ultimopharyngeal body may not ... In humans, it develops from the fourth pharyngeal pouch into the parafollicular cells of the thyroid to produce calcitonin. It ... Agathos EA, Tomos PI, Kostomitsopoulos N, Koutsoukos PG (February 2019). "Calcitonin as an anticalcification treatment for ...
https://en.wikipedia.org/wiki/Ultimopharyngeal_body
Vertebral compression fractureVertebral compression fracture
"Calcitonin for osteoporotic fractures". Archived from the original on 2009-06-08. Retrieved 2012-09-03. Knopp, Jennifer A.; ... For osteoporotic patients, calcitonin may be helpful. Kyphoplasty and vertebroplasty are minimally invasive procedures that ... Diner, Barry M.; Blitz, Maurice; Lyritis, George P.; Rowe, Brian H. (2004). "Calcitonin for treating acute pain of osteoporotic ...
https://en.wikipedia.org/wiki/Vertebral_compression_fracture
1964 in science1964 in science
Foster, G. V.; Baghdiantz, A.; Kumar, M. A.; Slack, E.; Soliman, H. A.; MacIntyre, I. (1964). "Thyroid origin of Calcitonin". ... June 27 - Iain Macintyre's group reports it has isolated and sequenced the newly-discovered hormone calcitonin and demonstrates ...
https://en.wikipedia.org/wiki/1964_in_science
SalcatoninSalcatonin
Synthetic salmon calcitonin may be used therapeutically in humans, as it is twenty times more active than human calcitonin and ... Calcitonin, as salmon calcitonin (sCT), is available in the pharmaceutical market as an injectable preparation for intravenous ... Salcatonin is the type of calcitonin hormone found in salmon. As in humans, salmon calcitonin is a peptide hormone secreted by ... Chesnut, CH; Azria, M; Silverman, S; Engelhardt, M; Olson, M; Mindeholm, L (2008). "Salmon calcitonin: a review of current and ...
https://en.wikipedia.org/wiki/Salcatonin
Iain MacintyreIain Macintyre
Macintyre's laboratory also purified and then sequenced both porcine calcitonin and human calcitonin. His team also ... Along with H. R. Morris he isolated and sequenced calcitonin gene-related peptide. Later research centred on the role played by ... Shortly after the hormone calcitonin had been described by Harold Copp, Macintyre's team was the first to isolate and sequence ... Foster, G. V.; Baghdiantz, A.; Kumar, M. A.; Slack, E.; Soliman, H. A.; MacINTYRE, I. (1964). "Thyroid origin of Calcitonin". ...
https://en.wikipedia.org/wiki/Iain_Macintyre
Failed back syndromeFailed back syndrome
Hollo I, Gergely I, Boross M (June 1977). "Smoking results in calcitonin resistance". JAMA. 237 (23): 2470. doi:10.1001/jama. ... Nicotine appears to interfere with bone metabolism through induced calcitonin resistance and decreased osteoblastic function. ...
https://en.wikipedia.org/wiki/Failed_back_syndrome
Stanton CohnStanton Cohn
"Treatment of osteoporosis with calcitonin". Seminars in Drug Treatment. 2 (1): 21-5. PMID 5065516. Cohn, S.H; Shukla, K.K; ...
https://en.wikipedia.org/wiki/Stanton_Cohn
CafedrineCafedrine
Fenethylline Theodrenaline Morton IK, Hall JM (1999). "Calcitonin gene-related peptide receptor antagonist". Concise Dictionary ...
https://en.wikipedia.org/wiki/Cafedrine
Parathyroid adenomaParathyroid adenoma
The action of calcitonin opposes PTH. When a parathyroid adenoma causes hyperparathyroidism, more parathyroid hormone is ...
https://en.wikipedia.org/wiki/Parathyroid_adenoma
SclerostinSclerostin
June 2010). "Calcitonin impairs the anabolic effect of PTH in young rats and stimulates expression of sclerostin by osteocytes ... Sclerostin production is increased by calcitonin. Thus, osteoblast activity is self regulated by a negative feedback system. ...
https://en.wikipedia.org/wiki/Sclerostin
ThyroidThyroid
Parafollicular cells produce calcitonin in response to high blood calcium. Calcitonin decreases the release of calcium from ... These cells secrete calcitonin and so are also called C cells. In the development of the embryo, at 3-4 weeks gestational age, ... Calcitonin plays a role in calcium homeostasis. Secretion of the two thyroid hormones is regulated by thyroid-stimulating ... The effects of calcitonin are opposite those of the parathyroid hormone (PTH) produced in the parathyroid glands. However, ...
https://en.wikipedia.org/wiki/Thyroid
StanniocalcinStanniocalcin
Unlike calcitonin, it also regulates phosphate level. It inhibits excretion of phosphate from the kidney. Stanniocalcin was ... By the mid 1970s, it was confirmed that the corpuscles secrete a factor that can reduce calcium level, similar to calcitonin ... Even though other calcium-decreasing hormone, calcitonin, is also present, these fishes require more efficient hormone as ...
https://en.wikipedia.org/wiki/Stanniocalcin
Genta (company)Genta (company)
A randomized, double-blind comparison to calcitonin". Annals of Internal Medicine. Vol. 108, no. 5. pp. 669-74. doi:10.7326/ ... including injectable calcitonin and intravenous etidronate. Concurrent studies also suggested clinical activity in patients ...
https://en.wikipedia.org/wiki/Genta_(company)
AKTIPAKTIP
Aiyar N, Rand K, Elshourbagy NA, Zeng Z, Adamou JE, Bergsma DJ, Li Y (Jun 1996). "A cDNA encoding the calcitonin gene-related ... Fluhmann B, Muff R, Hunziker W, Fischer JA, Born W (Feb 1995). "A human orphan calcitonin receptor-like structure". Biochem ...
https://en.wikipedia.org/wiki/AKTIP
S100A12S100A12
Maayan C, Becker Y, Gesundheit B, Girgis SI (2002). "Calcitonin gene related peptide in familial dysautonomia". Neuropeptides. ...
https://en.wikipedia.org/wiki/S100A12
Bone metastasisBone metastasis
A Cochrane review of calcitonin for the treatment of metastatic bone pain suggests calcitonin yields no significant benefit in ... Martinez-Zapata, MJ (2012). "Calcitonin used to treat metastatic bone pain". Cochrane Database Syst Rev (3): CD003223. doi: ...
https://en.wikipedia.org/wiki/Bone_metastasis
Parathyroid hormoneParathyroid hormone
PTH is secreted when [Ca2+] is decreased (calcitonin is secreted when serum calcium levels are elevated). The G-protein-coupled ... Its action is opposed by the hormone calcitonin. There are two types of PTH receptors. Parathyroid hormone 1 receptors, ...
https://en.wikipedia.org/wiki/Parathyroid_hormone
Susan BrainSusan Brain
Brain, S. D.; Williams, T. J.; Tippins, J. R.; Morris, H. R.; MacIntyre, I. (1985). "Calcitonin gene-related peptide is a ... In her early career she discovered the Calcitonin gene-related peptide receptor antagonist (CGRP) as a potent microvascular ...
https://en.wikipedia.org/wiki/Susan_Brain
Frans van BuchemFrans van Buchem
Van Buchem, FS (1970). "The pathogenesis of hyperostosis corticalis generalisata and calcitonin". Proceedings of the ...
https://en.wikipedia.org/wiki/Frans_van_Buchem
NeurotransmissionNeurotransmission
ACh-calcitonin gene-related peptide (CGRP) co-release. Glutamate-dynorphin co-release (in hippocampus). Noradrenaline and ATP ...
https://en.wikipedia.org/wiki/Neurotransmission
RodenticideRodenticide
The hormone calcitonin is no longer commonly used. Other chemical poisons include: ANTU (α-naphthylthiourea; specific against ...
https://en.wikipedia.org/wiki/Rodenticide
Endocrine glandEndocrine gland
Calcitonin, produced by the parafollicular cells (C cells) of the thyroid gland in response to rising blood calcium levels, ... The parathyroid hormone is the antagonist of calcitonin. Parathyroid hormone release is triggered by falling blood calcium ...
https://en.wikipedia.org/wiki/Endocrine_gland
Antimigraine drugAntimigraine drug
They are calcitonin gene-related peptide (CGRP) receptor antagonists. Gepants have been suggested to have less pain relief at 2 ... and Calcitonin-Gene-Related Peptide (CGRP) Receptor Monoclonal Antibodies". Pharmaceutics. 12 (12): 1180. doi:10.3390/ ...
https://en.wikipedia.org/wiki/Antimigraine_drug
Calcitonin Test: MedlinePlus Medical TestCalcitonin Test: MedlinePlus Medical Test
A calcitonin test checks the level of calcitonin, a thyroid hormone, in your blood. Its mainly used to help diagnose and ... What is a calcitonin test?. A calcitonin test measures the level of calcitonin in a sample of your blood. Calcitonin is a ... A high calcitonin level means that the C cells in your thyroid are making too much calcitonin. The higher the level, the more ... Why do I need a calcitonin test?. You may need a calcitonin test to help check for medullary thyroid cancer or C-cell ...
https://medlineplus.gov/lab-tests/calcitonin-test/
Serum Calcitonin Detects Medulla Thyroid CancerSerum Calcitonin Detects Medulla Thyroid Cancer
Measuring serum calcitonin in patients with thyroid nodules can detect cases of medullary thyroid cancer and is recommended as ... She said the cost of the calcitonin test in this study ($40 per patient) seems low, and she explained that this is quite a ... Measuring Serum Calcitonin in Patients With Thyroid Nodules Detects Medullary Thyroid Cancer - Medscape - Oct 23, 2007. ... European studies have shown that routine measurement of serum calcitonin in patients with thyroid nodules can detect cases of ...
https://www.medscape.com/viewarticle/564671
Browsing by Subject "Calcitonin"
World Health Organization. Biologicals Unit; WHO Expert Committee on Biological Standardization (‎1984 : Geneva, Switzerland)‎ (‎World Health OrganizationWorld Health Organization, 1984)‎ ...
https://apps.who.int:80/iris/browse?authority=Calcitonin&type=mesh
Browsing by Subject CalcitoninBrowsing by Subject "Calcitonin"
World Health Organization. Biologicals Unit; WHO Expert Committee on Biological Standardization (‎1984 : Geneva, Switzerland)‎ (‎World Health OrganizationWorld Health Organization, 1984)‎ ...
https://extranet.who.int/iris/restricted/browse?authority=Calcitonin&type=mesh
Phase II Study of Calcitonin for Tumoral Calcinosis - Tabular View - ClinicalTrials.govPhase II Study of Calcitonin for Tumoral Calcinosis - Tabular View - ClinicalTrials.gov
Phase II Study of Calcitonin for Tumoral Calcinosis. The safety and scientific validity of this study is the responsibility of ... Determine how repetitive calcitonin administration alters the biochemical markers of bone metabolism in osteopenic patients ... Determine whether calcitonin reduces or prevents tumor recurrence. III. Determine whether hyperphosphatemia abolishes the ... PROTOCOL OUTLINE: Patients are treated with subcutaneous injections of salmon calcitonin every 3 weeks. Ondansetron ...
https://clinicaltrials.gov/ct2/show/record/NCT00004358?view=results
Calcitonin Injection - Side Effects, Interactions, Uses, Dosage, Warnings | Everyday HealthCalcitonin Injection - Side Effects, Interactions, Uses, Dosage, Warnings | Everyday Health
Learn more about Calcitonin Injection at EverydayHealth.com. ... Find everything you need to know about Calcitonin Injection, ... How to take Calcitonin Injection (Injectable)?. Use Calcitonin Injection (Injectable) exactly as directed on the label, or as ... Calcitonin injection is not a cure for Pagets disease. You may have a relapse, especially if your body forms antibodies and ... Read and carefully follow any Instructions for Use provided with your medicine. Do not use calcitonin if you dont understand ...
https://www.everydayhealth.com/drugs/calcitonin-injection
JCI - The regulation of calcitonin in normal human plasma as assessed by immunoprecipitation and immunoextraction.JCI - The regulation of calcitonin in normal human plasma as assessed by immunoprecipitation and immunoextraction.
This procedure was used to measure calcitonin in normal adults. The mean (+/- SE) plasma calcitonin in 43 subjects was 10 (+/- ... In this method, endogenous calcitonin is immunoprecipitated with specific antibodies from a 10-ml plasma sample. The calcitonin ... A+ the end of a 3-h calcium infusion (12 mg/kg), mean plasma calcitonin in 10 subjects had risen to 114 (+/- 21) pg/ml. In 11 ... In any case, this procedure has allowed us to determine that the low concentrations of plasma calcitonin in normal adults are ...
https://www.jci.org/articles/view/108162/scanned-page/840
SMART: CALCITONIN domain annotationSMART: CALCITONIN domain annotation
This family is formed by calcitonin, the calcitonin gene-related peptide, and amylin. They are short polypeptide hormones. ... Calcitonin receptor-stimulating peptide 1 stimulates cAMP production via the calcitonin receptor. ... Calcitonin [ (PUBMED:3060108) ] is a 32 amino acid polypeptide hormone that causes a rapid but short-lived drop in the level of ... EFFECTS OF S-SULFONATION ON THE SOLUTION STRUCTURE OF SALMON CALCITONIN. 2g48. crystal structure of human insulin-degrading ...
http://smart.embl.de/smart/do_annotation.pl?DOMAIN=CALCITONIN&BLAST=DUMMY
The Interrelationships between Vitamin D Parathyroid Hormone and Calcitonin | Clinical Science | Portland PressThe Interrelationships between Vitamin D Parathyroid Hormone and Calcitonin | Clinical Science | Portland Press
The Interrelationships between Vitamin D Parathyroid Hormone and Calcitonin L. F. Hill; L. F. Hill ... L. F. Hill, E. B. Mawer; The Interrelationships between Vitamin D Parathyroid Hormone and Calcitonin. Clin Sci Mol Med 1 ...
https://portlandpress.com/clinsci/article-abstract/44/2/4P/70328/The-Interrelationships-between-Vitamin-D?redirectedFrom=fulltext
Human calcitonin stimulates salivary amylase output in man. | GutHuman calcitonin stimulates salivary amylase output in man. | Gut
Salivary amylase output in man increases after injection of synthetic human calcitonin. This effect is dose dependent. ...
https://gut.bmj.com/content/17/8/620
CALCITONIN HUMAN branded drug formulation and manufacturing methodsCALCITONIN HUMAN branded drug formulation and manufacturing methods
Formulation information for generic ingredient: CALCITONIN HUMAN. ⮩ Send this page by email. ✉ Email this page to a colleague ...
https://www.drugpatentwatch.com/p/formulation/CALCITONIN+HUMAN/i
Online Calcitonin Blood Test | Discounted Calcitonin Blood Test | Request A TestOnline Calcitonin Blood Test | Discounted Calcitonin Blood Test | Request A Test
A Calcitonin blood test can help diagnose a rare form of thyroid cancer or assist in treating certain bone disorders. Order ... Calcitonin Blood Test (Labcorp). This test measures levels of Calcitonin in the blood. Calcitonin is a hormone produced by the ... Calcitonin Blood Test (Quest). This test measures levels of Calcitonin in the blood. Calcitonin is a hormone produced by the ... Calcitonin Blood Test (Labcorp). This test measures levels of Calcitonin in the blood. Calcitonin is a hormone produced by the ...
https://requestatest.com/calcitonin-blood-test
Pharmacologic Characterization of AMG 334, a Potent and Selective Human Monoclonal Antibody against the Calcitonin Gene-Related...Pharmacologic Characterization of AMG 334, a Potent and Selective Human Monoclonal Antibody against the Calcitonin Gene-Related...
calcitonin gene-related peptide. CRLR. calcitonin receptor-like receptor. cyno. cynomolgus monkey. DBF. dermal blood flow. DMEM ... Human calcitonin8-32 peptide was used as the positive control for experiments involving the calcitonin and amylin receptors. IC ... 1992). Comparison of a calcitonin gene-related peptide receptor in a human neuroblastoma cell line (SK-N-MC) and a calcitonin ... CGRP belongs to the calcitonin family of peptides that also consists of adrenomedullin, calcitonin, and amylin, all of which ...
https://jpet.aspetjournals.org/content/356/1/223?ijkey=3387347501658dd1198f79d429f439043f27391b&keytype2=tf_ipsecsha
Calcitonin gene related peptide and neuropeptide Y in skeletal muscle after eccentric exercise: a microdialysis study | British...Calcitonin gene related peptide and neuropeptide Y in skeletal muscle after eccentric exercise: a microdialysis study | British...
Calcitonin gene related peptide and neuropeptide Y in skeletal muscle after eccentric exercise: a microdialysis study ... Calcitonin gene related peptide and neuropeptide Y in skeletal muscle after eccentric exercise: a microdialysis study ... Calcitonin gene related peptide and neuropeptide Y in skeletal muscle after eccentric exercise: a microdialysis study ...
https://bjsm.bmj.com/content/40/3/264.share
European Headache Federation guideline on the use of monoclonal antibodies targeting the calcitonin gene related peptide...European Headache Federation guideline on the use of monoclonal antibodies targeting the calcitonin gene related peptide...
European Headache Federation guideline on the use of monoclonal antibodies targeting the calcitonin gene related peptide ... European Headache Federation guideline on the use of monoclonal antibodies targeting the calcitonin gene related peptide ... guideline addressed the use of monoclonal antibodies targeting the calcitonin gene-related peptide (CGRP) pathway to prevent ...
https://www.cun.es/en/research/scientific-publications/european-headache-federation-guideline-use-monoclonal-antibodies-calcitonin-gene-migraine-prevention
HiTSeeker Calcitonin Receptor Cell Line - Innoprot GPCR Cell LineHiTSeeker Calcitonin Receptor Cell Line - Innoprot GPCR Cell Line
Each vial of HiTSeeker calcitonin receptor Cell Line contains HEK293 cells stably expressing human calcitonin receptor with no ... HiTSeeker Calcitonin Receptor Cell Line. Reference: P30136. HiTSeeker Calcitonin Receptor Cell Line. HiTSeeker are cell lines ... The calcitonin receptor is a GPCR in the same group B sub-family that also includes the receptors for vasoactive intestinal ... Calcitonin Receptor is able to decrease blood calcium levels by both; direct inhibition of mediated bone resorption and also by ...
https://innoprot.com/product/hitseeker-calcitonin-receptor-cell-line/
Calcitonin Gene-Related Peptide-I, Human - CAS 90954-53-3 - Calbiochem | 05-23-2404Calcitonin Gene-Related Peptide-I, Human - CAS 90954-53-3 - Calbiochem | 05-23-2404
Calbiochem Calcitonin Gene-Related Peptide-I, Human, CAS 90954-53-3, is a potent and long-acting vasodilator. Increases plasma ... Calcitonin Gene-Related Peptide-I, Human - CAS 90954-53-3 - Calbiochem. 05-23-2404 Sigma-AldrichCalcitonin Gene-Related Peptide ... More,, Calcitonin Gene-Related Peptide-I, Human, CAS 90954-53-3, is a potent and long-acting vasodilator. Increases plasma ... Calcitonin Gene-Related Peptide-I, Human, CAS 90954-53-3, is a potent and long-acting vasodilator. Increases plasma levels of ...
https://www.merckmillipore.com/AE/en/product/Calcitonin-Gene-Related-Peptide-I-Human-CAS-90954-53-3-Calbiochem,EMD_BIO-05-23-2404
Calcitonin Receptor-Like Protein | Colorado PROFILES
"Calcitonin Receptor-Like Protein" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH ( ... Sensitization of calcitonin gene-related peptide receptors by receptor activity-modifying protein-1 in the trigeminal ganglion ... This graph shows the total number of publications written about "Calcitonin Receptor-Like Protein" by people in this website by ... When bound to RECEPTOR ACTIVITY-MODIFYING PROTEIN 1 it forms the CALCITONIN GENE-RELATED RECEPTOR. When bound to RECEPTOR ...
https://profiles.ucdenver.edu/display/21257666
Erratum to: Opposing expression gradients of calcitonin-related polypeptide alpha (Calca/Cgrpα) and tyrosine hydroxylase (Th)...
Sherry Wu, J., Vyas, P., Glowatzki, E., & Fuchs, P. A. (2018). Erratum to: Opposing expression gradients of calcitonin-related ... Sherry Wu, J, Vyas, P, Glowatzki, E & Fuchs, PA 2018, Erratum to: Opposing expression gradients of calcitonin-related ... Dive into the research topics of Erratum to: Opposing expression gradients of calcitonin-related polypeptide alpha (Calca/Cgrp ... T2 - Opposing expression gradients of calcitonin-related polypeptide alpha (Calca/Cgrpα) and tyrosine hydroxylase (Th) in type ...
https://jhu.pure.elsevier.com/en/publications/erratum-to-opposing-expression-gradients-of-calcitonin-related-po
Receptor Activity-modifying Protein-directed G Protein Signaling Specificity for the Calcitonin Gene-related Peptide Family of...
The calcitonin gene-related peptide (CGRP) family of G protein-coupled receptors (GPCRs) is formed through the association of ... Receptor Activity-modifying Protein-directed G Protein Signaling Specificity for the Calcitonin Gene-related Peptide Family of ... 2016). Receptor Activity-modifying Protein-directed G Protein Signaling Specificity for the Calcitonin Gene-related Peptide ... the calcitonin receptor-like receptor (CLR) and one of three receptor activity-modifying proteins (RAMPs). Binding of one of ...
https://www.repository.cam.ac.uk/handle/1810/260854
DIAsource - Calcitonin (CT)DIAsource - Calcitonin (CT)
home_diasource/ruo_products/immunoassays/cancer_markers/calcitonin_ct/ct_elisa_ultra_sensitive_96_tests_for_research_use_only ... home_diasource/RUO-Products/ImmunoAssays/Cancer-Markers/Calcitonin-CT/CT-ELISA-Ultra-Sensitive-96-tests-For-Research-Use-Only ... RUO-Products/ImmunoAssays/Cancer-Markers/Calcitonin-CT/CT-ELISA-Ultra-Sensitive-96-tests-For-Research-Use-Only. ... RUO-Products/ImmunoAssays/Cancer-Markers/Calcitonin-CT/CT-ELISA-Ultra-Sensitive-96-tests-For-Research-Use-Only. ...
https://www.diasource-diagnostics.com/RUO-Products/ImmunoAssays/Cancer-Markers/Calcitonin-CT
Treatment with pertussis toxin does not prevent central effects of eel calcitoninTreatment with pertussis toxin does not prevent central effects of eel calcitonin
Receptors, Calcitonin ; Adenylate Cyclase Toxin ; Animals ; Calcitonin ; Brain ; Corpus Striatum ; Pain Measurement ; Adenylate ... Treatment with pertussis toxin does not prevent central effects of eel calcitonin. F. Guidobono. Primo. ;P. Bettica;I. Villa;F ... To determine whether or not the CNS inhibitory activity of eel calcitonin (eCT) on adenylyl cyclase is the endocellular ... Treatment with pertussis toxin does not prevent central effects of eel calcitonin / F. Guidobono, P. Bettica, I. Villa, F. ...
https://air.unimi.it/handle/2434/177576
IMSEAR at SEARO: Calcitonin in therapy.
Calcitonin in therapy. Journal of the Indian Medical Association. 1972 Apr; 58(8): 290-1. ...
https://imsear.searo.who.int/handle/123456789/105123
Journal: Biomaterials / Subject: 3 selected / Subject term: calcitonin receptors and chondrogenesis - PubAg Search ResultsJournal: Biomaterials / Subject: 3 selected / Subject term: calcitonin receptors and chondrogenesis - PubAg Search Results
In this study, the related mechanisms of calcitonin on the regeneration of hNP and the effects of calcitonin on the age-related ... calcitonin; calcitonin receptors; chondrogenesis; cyclic AMP; humans; phenotype; signal transduction; therapeutics. Abstract:. ... calcitonin Remove constraint Subject: calcitonin Subject chondrogenesis Remove constraint Subject: chondrogenesis Subject term ... calcitonin receptors Remove constraint Subject term: calcitonin receptors Subject term chondrogenesis Remove constraint Subject ...
https://pubag.nal.usda.gov/?f%5Bjournal_facet%5D%5B%5D=Biomaterials&f%5Bsubject_facet%5D%5B%5D=cyclic+AMP&f%5Bsubject_facet%5D%5B%5D=calcitonin&f%5Bsubject_facet%5D%5B%5D=chondrogenesis&f%5Bsubject_term%5D%5B%5D=calcitonin+receptors&f%5Bsubject_term%5D%5B%5D=chondrogenesis&per_page=50&search_field=author&sort=date-asc
Calcium homeostasis, parathyroid hormone, and calcitonin: preliminary report. - WikidataCalcium homeostasis, parathyroid hormone, and calcitonin: preliminary report. - Wikidata
Osteoporosis Medication: Calcium Metabolism Modifiers, Parathyroid Hormone Analogs, Selective Estrogen Receptor Modulator,...Osteoporosis Medication: Calcium Metabolism Modifiers, Parathyroid Hormone Analogs, Selective Estrogen Receptor Modulator,...
... studies do show an increase in BMD with the use of calcitonin. Calcitonin increases BMD at the lumbar spine by 1-1.5%. It ... Calcitonin is used for the treatment of postmenopausal osteoporosis in women more than 5 years post menopause with low bone ... Use of calcitonin-salmon injection is recommended in conjunction with adequate calcium and vitamin D intake to prevent the ... Calcitonin-salmon injection should be reserved for patients who refuse or cannot tolerate bisphosphonatse or in whom ...
https://emedicine.medscape.com/article/330598-medication
CalcitoninCalcitonin
Services | CalcitoninServices | Calcitonin
Calcitonin adalah hormon yang diproduksi oleh sel-sel tertentu dalam tiroid yang disebut sebagai sel-C. Tiroid merupakan ... Pemeriksaan calcitonin mengukur konsentrasi hormon calcitonin dalam darah. ... Pemeriksaan calcitonin mengukur konsentrasi hormon calcitonin dalam darah. Calcitonin adalah hormon yang diproduksi oleh sel- ... Pemeriksaan calcitonin bermanfaat untuk : Diagnosis hyperplasia C-sel dan kanker medula tiroid Pemantauan bagi pasien dengan ...
http://apps.helix.co.id/services/detail/calcitonin
Calcitonin | Northwestern MedicineCalcitonin | Northwestern Medicine
Calcitonin is a hormone secreted by your thyroid. ... This blood test measures the level of calcitonin in your blood ...
https://encyclopedia.nm.org/InteractiveTools/Quizzes/167,calcitonin
Calcitonin and calcitonin-gene related peptide inhibition of insulin secretion in vitro - Fingerprint - UTMB Health...Calcitonin and calcitonin-gene related peptide inhibition of insulin secretion in vitro - Fingerprint - UTMB Health...
Dive into the research topics of Calcitonin and calcitonin-gene related peptide inhibition of insulin secretion in vitro. ... Calcitonin and calcitonin-gene related peptide inhibition of insulin secretion in vitro. ...
https://researchexperts.utmb.edu/en/publications/calcitonin-and-calcitonin-gene-related-peptide-inhibition-of-insu/fingerprints/
CGRPReceptorsSalmonFamily of peptidesMedullary thyroiStudy of CalcitoninSerum calcitoninGeneSecretionHormoneStimulatesAntibodiesDiagnosisHumanEstrogenHypercalcemiaInjectionOsteoporosisIntravenousLevelsCalcium homeostasisHttpsInsulinIncidenceMeSHAssayFracturesReducesBone painConcentrations
CGRP18
  • Alternative splicing of the gene coding for calcitonin produces a distantly related peptide of 37 amino acids, called calcitonin gene-related peptide (CGRP), beta type. (embl.de)
  • Therapeutic agents that block the calcitonin gene-related peptide (CGRP) signaling pathway are a highly anticipated and promising new drug class for migraine therapy, especially after reports that small-molecule CGRP-receptor antagonists are efficacious for both acute migraine treatment and migraine prevention. (aspetjournals.org)
  • AMG 334 fully inhibited CGRP-stimulated cAMP production with an IC 50 of 2.3 nM in cell-based functional assays (human CGRP receptor) and was 5000-fold more selective for the CGRP receptor than other human calcitonin family receptors, including adrenomedullin, calcitonin, and amylin receptors. (aspetjournals.org)
  • Calcitonin gene-related peptide (CGRP) is a 37-amino-acid-long peptide expressed in both the central and peripheral nervous systems. (aspetjournals.org)
  • A previous European Headache Federation (EHF) guideline addressed the use of monoclonal antibodies targeting the calcitonin gene-related peptide (CGRP) pathway to prevent migraine. (cun.es)
  • This receptor family comprises a group of receptors for the calcitonin/CGRP family of peptides. (innoprot.com)
  • The calcitonin gene-related peptide (CGRP) family of G protein-coupled receptors (GPCRs) is formed through the association of the calcitonin receptor-like receptor (CLR) and one of three receptor activity-modifying proteins (RAMPs). (cam.ac.uk)
  • IAPP is structurally similar to calcitonin gene-related peptide (CGRP). (utmb.edu)
  • Calcitonin Gene Related Peptide (CGRP) is produced in central and peripheral neurons and binds to the herterodimeric CGRP receptors found throughout the body. (echelon-inc.com)
  • Calcitonin-gene-related peptide (CGRP), a neuropeptide broadly distributed in neuronal and non-neuronal regions throughout the body, plays a fundamental role in migraine and cluster headache (CH) pathophysiology. (clusterheadachewarriors.org)
  • Targeting the calcitonin gene-related peptide (CGRP) pathway to treat these headaches may be the first focused therapeutic option to date, with the potential for promising efficacy. (clusterheadachewarriors.org)
  • The effects of pregnancy and estrogen on the expression of calcitonin gene-related peptide (CGRP) in the uterine cervix, dorsal root ganglia and spinal cord. (omeka.net)
  • The present study was designed to test the hypothesis that calcitonin gene-related peptide (CGRP), a neuropeptide co-stored with SP in many sensory neurons, undergoes changes with pregnancy and hormonal environment. (omeka.net)
  • In this immunohistochemical study, we examined the incidence, morphology, and distribution of calcitonin gene-related peptide (CGRP) immunoreactivity in epithelial cells the rat respiratory tract, using peroxidase anti-peroxidase (PAP) techniques. (elsevier.com)
  • The goal of this study was to determine if skeletal muscle injury induced by exposure to injurious stretch-shortening cycles (iSSCs), resulted in hyperalgesia in the hind limb and changes in calcitonin-gene related peptide (CGRP) immunolabeling in the dorsal root ganglia (DRG) in young and old male rats. (cdc.gov)
  • The receptors for calcitonin gene-related peptide (CGRP) and adrenomedullin (AM) are complexes of the calcitonin receptor-like receptor (CLR) and receptor activity-modifying proteins (RAMP). (aston.ac.uk)
  • The effects of asphalt fumes on nasal mucosal innervation were examined by measuring SP and calcitonin-gene-related peptide (CGRP) levels in rat TG neurons projecting to the nasal epithelium. (cdc.gov)
  • The most common classes of drugs are called "triptans" and "CGRP antagonists" (CGRP stands for calcitonin gene-related peptide). (medlineplus.gov)
Receptors3
  • The calcitonin receptor is a GPCR in the same group B sub-family that also includes the receptors for vasoactive intestinal peptide, secretin, and PTH and PTHrP. (innoprot.com)
  • Sensitization of calcitonin gene-related peptide receptors by receptor activity-modifying protein-1 in the trigeminal ganglion. (ucdenver.edu)
  • Receptor Activity-modifying Protein-directed G Protein Signaling Specificity for the Calcitonin Gene-related Peptide Family of Receptors. (cam.ac.uk)
Salmon12
  • PROTOCOL OUTLINE: Patients are treated with subcutaneous injections of salmon calcitonin every 3 weeks. (clinicaltrials.gov)
  • You should not use this medicine if you are allergic to salmon calcitonin. (everydayhealth.com)
  • Solution conformation of salmon calcitonin in sodium dodecyl sulfate micelles as determined by two-dimensional NMR and distance geometry calculations. (embl.de)
  • The 32 amino acid hormone salmon calcitonin was studied at pH 3.7 and 7.4 by two-dimensional NMR in sodium dodecyl sulfate (SDS) micelles at 310 K. The spectrum was fully assigned, and the secondary structure was obtained from nuclear Overhauser enhancement spectroscopy (NOESY), 3JHN alpha coupling constants, and slowly exchanging amide data. (embl.de)
  • Calcitonin-salmon injection should be reserved for patients who refuse or cannot tolerate bisphosphonatse or in whom bisphosphonates are contraindicated. (medscape.com)
  • Use of calcitonin-salmon injection is recommended in conjunction with adequate calcium and vitamin D intake to prevent the progressive loss of bone mass. (medscape.com)
  • Calcitonin(Salmon) is used to treat osteoporosis in women who are at least 5 years past menopause and cannot or do not want to take estrogen products. (pharmaffiliates.com)
  • Reference standards of Calcitonin(Salmon) API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below. (pharmaffiliates.com)
  • People, who are looking for a discount on medication from drug stores, will find our CALCITONIN-SALMON coupon to be very helpful. (prescription-cards.com)
  • The great thing about this CALCITONIN-SALMON discount is that it never expires. (prescription-cards.com)
  • If your pharmacist has any queries regarding the processing information, a helpline number is also provided at the bottom of the CALCITONIN-SALMON discount savings coupon which can make things easy for you and them. (prescription-cards.com)
  • Salmon calcitonin (sCT), which is more potent and longer lasting than human CT, has been used widely for the treatment of osteoporosis, paget's disease, hypercalcemic shock and chronic pain in terminal cancer patients. (peptide-steroids.com)
Family of peptides1
  • The calcitonin family of peptides. (embl.de)
Medullary thyroi2
  • That's because medullary thyroid cancer and C-cell hyperplasia don't always cause high calcitonin. (medlineplus.gov)
  • European studies have shown that routine measurement of serum calcitonin in patients with thyroid nodules can detect cases of unsuspected medullary thyroid cancer (MTC), leading to improved outcomes. (medscape.com)
Study of Calcitonin1
  • Association study of calcitonin gene-related polypeptide-alpha (CALCA) gene polymorphism with migraine. (cdc.gov)
Serum calcitonin5
  • Currently, the ATA guidelines do not recommend measuring serum calcitonin levels in this workup, and the authors of the guidelines said they could not "recommend either for or against it. (medscape.com)
  • Hence, they calculated that the cost of detecting 1 MTC case by measuring serum calcitonin is $5122 (range, $2916 - $15,365). (medscape.com)
  • Screening patients with thyroid nodules for serum calcitonin to identify those with elevated levels would detect only this particular type of thyroid cancer, Dr. Franklyn pointed out: "The researchers say the prevalence was estimated at 0.78%, which is similar to the prevalence rates I've quoted above. (medscape.com)
  • The aim of this study was to evaluate the contribution of serum calcitonin measurement in the diagnostic evaluation of thyroid nodules with insufficient, indeterminate, or suspicious cytology. (bjbms.org)
  • In conclusion, routine serum calcitonin measurement can be performed in selected cases rather than in all nodular thyroid patients. (bjbms.org)
Gene18
  • This family is formed by calcitonin, the calcitonin gene-related peptide, and amylin. (embl.de)
  • Solution structure of human calcitonin gene-related peptide by 1H NMR and distance geometry with restrained molecular dynamics. (embl.de)
  • The structure of human calcitonin gene-related peptide 1 (hCGRP-1) has been determined by 1H NMR in a mixed-solvent system of 50% trifluoroethanol/50% H2O at pH 3.7 and 27 degrees C. Complete resonance assignment was achieved by using two-dimensional methods. (embl.de)
  • This gene encodes a high affinity receptor for the peptide hormone Calcitonin. (innoprot.com)
  • Calcitonin Gene-Related Peptide-I, Human, CAS 90954-53-3, is a potent and long-acting vasodilator. (merckmillipore.com)
  • Association of low bone mass with vitamin d receptor gene and calcitonin receptor gene polymorphisms in juvenile idiopathic arthritis. (unifi.it)
  • Pulmonary calcitonin gene-related peptide immunoreactivity: nerve-endocrine cell interrelationships. (elsevier.com)
  • Dive into the research topics of 'Pulmonary calcitonin gene-related peptide immunoreactivity: nerve-endocrine cell interrelationships. (elsevier.com)
  • Changes in the expression of calcitonin gene-related peptide after exposure to injurious stretch-shortening contractions. (cdc.gov)
  • Subcutaneous calcitonin gene-related peptide antagonists have been approved for preventive therapy in chronic migraine. (medscape.com)
  • However, two oral calcitonin gene-related antagonists, ubrogepant and rimegepant , were recently approved by the U.S. Food and Drug Administration for the acute treatment of migraine. (medscape.com)
  • The protein encoded by the CALCRL gene is a G protein-coupled receptor related to the calcitonin receptor. (cgrpreceptor.com)
  • The effect of orthodontic forces on calcitonin gene-related peptide expression in human dental pulp. (bvsalud.org)
  • Association study of the calcitonin gene-related polypeptide-alpha (CALCA) and the receptor activity modifying 1 (RAMP1) genes with migraine. (cdc.gov)
  • Calcitonin gene related peptide gene polymorphism in migraine patients. (cdc.gov)
  • The balance of parathyroid hormone (PTH), calcitonin, and vitamin D has long been considered the main regulator of calcium metabolism, but the function of other "actors", such as fibroblast growth factor-23 (FGF-23), Klotho gene, and transient receptor potential cation channel, subfamily V, member 5 (TPRV5) should be considered. (eurekaselect.com)
  • BACKGROUND AND AIM: Monoclonal antibodies acting on the calcitonin gene-related peptide or on its receptor are new drugs to prevent migraine. (bvsalud.org)
  • Four monoclonal antibodies have been developed: one targeting the calcitonin gene-related peptide receptor (erenumab) and three targeting the calcitonin gene-relat. (bvsalud.org)
Secretion1
  • We have studied the secretion of calcitonin in normal adults with a new procedure of increased sensitivity for the measurement of the hormone in peripheral plasma. (jci.org)
Hormone9
  • Calcitonin is a hormone that helps control the level of calcium in your blood. (medlineplus.gov)
  • OBJECTIVES: I. Determine whether intermittent, long-term, subcutaneous administration of calcitonin increases phosphaturia, reduces hyperphosphatemia, and increases intact parathyroid hormone levels in patients with tumoral calcinosis. (clinicaltrials.gov)
  • Calcitonin is a man-made form of a hormone that occurs naturally in the thyroid gland. (everydayhealth.com)
  • Our data may underestimate calcitonin levels since not all of the heterogenous species of hormone may be extracted by this method. (jci.org)
  • Calcitonin [ ( PUBMED:3060108 ) ] is a 32 amino acid polypeptide hormone that causes a rapid but short-lived drop in the level of calcium and phosphate in the blood, by promoting the incorporation of these ions in the bones. (embl.de)
  • Calcitonin is a hormone produced by the Thyroid Gland . (requestatest.com)
  • Calcium homeostasis, parathyroid hormone, and calcitonin: preliminary report. (wikidata.org)
  • Calcitonin (CT) is a peptide hormone produced by the parafollicular cells of the thyroid gland in mammals and by the ultimobranchial gland of birds and fish. (peptide-steroids.com)
  • They release parathyroid hormone, which controls the level of calcium in the blood with the help of calcitonin (pronounced: kal-suh-TOE-nin), which the thyroid makes. (kidshealth.org)
Stimulates3
  • Calcitonin receptor-stimulating peptide 1 stimulates cAMP production via the calcitonin receptor. (embl.de)
  • Human calcitonin stimulates salivary amylase output in man. (bmj.com)
  • Human calcitonin stimulates cyclic nucleotide accumulation in human kidney cortex and medulla. (bestbiochem.com)
Antibodies3
  • You may have a relapse, especially if your body forms antibodies and you become immune to calcitonin. (everydayhealth.com)
  • In this method, endogenous calcitonin is immunoprecipitated with specific antibodies from a 10-ml plasma sample. (jci.org)
  • The calcitonin is then dissociated from the antibodies and extracted into alcohol. (jci.org)
Diagnosis2
  • A calcitonin test may aid in the diagnosis when a person is suspected of having this form of cancer. (requestatest.com)
  • Calcitonin (CT) is a marker for both initial diagnosis and monitoring of patients with residual or recurrent medullary thyroid carcinoma (MTC). (bvsalud.org)
Human3
  • The regulation of calcitonin in normal human plasma as assessed by immunoprecipitation and immunoextraction. (jci.org)
  • Salivary amylase output in man increases after injection of synthetic human calcitonin. (bmj.com)
  • This antibody is designed for the specific localization of human calcitonin using IHC techniques in formalin-fixed, paraffin-embedded tissue sections. (anacrom.com)
Estrogen1
  • Calcium potentates the effect of estrogen and calcitonin on bone mass: review and analysis. (bvsalud.org)
Hypercalcemia2
  • Calcitonin injection is used to treat Paget's disease of bone, or high levels of calcium in the blood (hypercalcemia). (everydayhealth.com)
  • all had an overproduction of calcitonin and hypercalcemia. (curehunter.com)
Injection7
  • Calcitonin injection is also used to treat osteoporosis in postmenopausal women. (everydayhealth.com)
  • What is Calcitonin Injection (Injectable) used for? (everydayhealth.com)
  • You may have increased bone pain during the first few months of treatment with calcitonin injection. (everydayhealth.com)
  • Can I take Calcitonin Injection (Injectable) if I'm pregnant or breastfeeding? (everydayhealth.com)
  • Use Calcitonin Injection (Injectable) exactly as directed on the label, or as prescribed by your doctor. (everydayhealth.com)
  • Calcitonin injection is not a cure for Paget's disease. (everydayhealth.com)
  • To determine whether or not the CNS inhibitory activity of eel calcitonin (eCT) on adenylyl cyclase is the endocellular mechanism underlying the antinociceptive effect of the peptide, as shown for morphine analgesia, we administered Bordetella pertussis toxin (PTX) by intracerebroventricular (ICV) injection (0.5 microgram/rat) to block the receptor-mediated inhibition of adenylyl cyclase. (unimi.it)
Osteoporosis3
  • Calcitonin may also be used to treat people with osteoporosis or Paget's disease. (requestatest.com)
  • Calcitonin is used for the treatment of postmenopausal osteoporosis in women more than 5 years post menopause with low bone mass relative to healthy premenopausal females. (medscape.com)
  • Calcitonin maybe involved in osteoporosis and in Paget's disease. (bestbiochem.com)
Intravenous2
  • Additionally, intravenous administration of calcium-stimulated serum concentrations of procalcitonin (PCt) level, in addition to calcitonin (Ct) and MFNB, also confirmed elevated levels of Ct, PCt, and carcinoembryonic antigen (CEA) in the aspirate samples. (jofem.org)
  • Intravenous calcitonin 4 IU/kg every 12 hours was started. (medscape.com)
Levels6
  • The question is whether such screening for calcitonin levels is cost-effective, Dr. Franklyn continued. (medscape.com)
  • This test measures levels of Calcitonin in the blood. (requestatest.com)
  • Calcitonin production helps regulate the body's levels of calcium and phosphate. (requestatest.com)
  • A rare form of thyroid cancer which affects the C-cells, the same cells which produce calcitonin, may cause levels to be elevated. (requestatest.com)
  • In these cases, monitoring Calcitonin levels can help determine how well they are responding to therapy or find the optimal dosage. (requestatest.com)
  • Calcitonin levels by ECLIA correlate well with RIA values in higher range but are affected by sex, TgAb, and renal function in lower range. (bvsalud.org)
Calcium homeostasis2
  • In any case, this procedure has allowed us to determine that the low concentrations of plasma calcitonin in normal adults are responsive to perturbations of calcium homeostasis. (jci.org)
  • Calcitonin in particular is involved in the regulation of calcium homeostasis. (pureroots.bg)
Https1
  • 2017. https://anesth.unboundmedicine.com/anesthesia/view/GDT/619089/all/Calcitonin. (unboundmedicine.com)
Insulin1
  • In addition, his group is developing novel transmucosal and oral delivery systems for insulin, interferon-beta and calcitonin and is studying the potential of developing novel transmucosal systems for siRNA delivery. (utexas.edu)
Incidence1
  • Although no research data support the idea that the use of intranasal calcitonin reduces the incidence of fractures, studies do show an increase in BMD with the use of calcitonin. (medscape.com)
MeSH1
  • Calcitonin Receptor-Like Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (ucdenver.edu)
Assay4
  • She said the cost of the calcitonin test in this study ($40 per patient) seems low, and she explained that this is quite a complicated assay, which involves collecting the blood on ice. (medscape.com)
  • The alcohol is evaporated, and the calcitonin is recovered in assay diluent for subsequent radioimmunoassay. (jci.org)
  • Innoprot HiTSeeker Calcitonin Receptor Cell Line allows to assay compounds, or analyze their capability to modulate CALCR. (innoprot.com)
  • The calcitonin level was detected to be above the assay-specific cut-off in 23 (2.6%) patients ranging between 6.5 - 4450 pg/mL. (bjbms.org)
Fractures1
  • Calcitonin may rarely help acute pain associated with acute osteoporotic vertebral compression fractures. (medscape.com)
Reduces1
Bone pain2
  • Calcitonin for metastatic bone pain: Cochrane systematic review is a topic covered in the Cochrane Abstracts . (unboundmedicine.com)
  • Cochrane Abstracts , Evidence Central , evidence.unboundmedicine.com/evidence/view/Cochrane/434679/all/Calcitonin_for_metastatic_bone_pain:_Cochrane_systematic_review. (unboundmedicine.com)
Concentrations2
  • These results are consistent with our previous reports of the low concentrations of calcitonin in adult plasma. (jci.org)
  • RÉSUMÉ Afin de déterminer les effets du jeûne du ramadan sur la sécrétion d'hormones sexuelles chez des hommes célibataires en bonne santé, nous avons mesuré les concentrations sanguines de testostérone et d'hormones lutéinisante (LH) et folliculostimulante (FSH) chez 52 étudiants célibataires âgés de 18 à 24 ans qui jeûnaient pendant 12 heures ou plus pendant le ramadan. (who.int)
(emedicine.medscape.com)
Calcitonin medicines: limit long-term use
Calcitonin medicines: limit long-term use (apps.who.int)
تصفح Journal Articles حسب العنوان
تصفح Journal Articles حسب العنوان (apps.who.int:80)
Calcitonin Injection - Side Effects, Interactions, Uses, Dosage, Warnings | Everyday Health
Calcitonin Injection - Side Effects, Interactions, Uses, Dosage, Warnings | Everyday Health (everydayhealth.com)
Amyloidosis: Definition of Amyloid and Amyloidosis, Classification Systems, Systemic Amyloidoses
Amyloidosis: Definition of Amyloid and Amyloidosis, Classification Systems, Systemic Amyloidoses (medscape.com)
Prueba de calcitonina: Prueba de laboratorio de MedlinePlus
Prueba de calcitonina: Prueba de laboratorio de MedlinePlus (medlineplus.gov)
Aging changes in hormone production: MedlinePlus Medical Encyclopedia
Aging changes in hormone production: MedlinePlus Medical Encyclopedia (medlineplus.gov)
Thyroid Cancer | Thyroid Cancer Treatment | MedlinePlus
Thyroid Cancer | Thyroid Cancer Treatment | MedlinePlus (medlineplus.gov)
Thyroid Cancer Guidelines: Guidelines Summary, Thyroid Nodule Evaluation, Diagnosis
Thyroid Cancer Guidelines: Guidelines Summary, Thyroid Nodule Evaluation, Diagnosis (medscape.com)
Thyroid Tests: MedlinePlus
Thyroid Tests: MedlinePlus (medlineplus.gov)
Migraine Prophylaxis: 9 Preventive Therapies
Migraine Prophylaxis: 9 Preventive Therapies (healthline.com)
Calcitonin Salmon Injection: MedlinePlus Drug Information
Calcitonin Salmon Injection: MedlinePlus Drug Information (medlineplus.gov)
Phase II Study of Calcitonin for Tumoral Calcinosis - Tabular View - ClinicalTrials.gov
Phase II Study of Calcitonin for Tumoral Calcinosis - Tabular View - ClinicalTrials.gov (clinicaltrials.gov)
CALCITONIN 100 I.E. Rotexmedica Inj.-Lösung | Humanarzneimittel | Warengruppen | K & K Pharma
CALCITONIN 100 I.E. Rotexmedica Inj.-Lösung | Humanarzneimittel | Warengruppen | K & K Pharma (kkpharma.de)
Medullary Thyroid Cancer Management: 5 Things to Know
Medullary Thyroid Cancer Management: 5 Things to Know (medscape.com)
Hypercalcemia Medication: Bisphosphonates, Monoclonal Antibodies, Endocrine, Antidote, hypercalcemia agents, Glucocorticoids,...
Hypercalcemia Medication: Bisphosphonates, Monoclonal Antibodies, Endocrine, Antidote, hypercalcemia agents, Glucocorticoids,... (medscape.com)
Complex Regional Pain Syndrome Type 1 (Reflex Sympathetic Dystrophy) Medication: Sympatholytics, Anti-inflammatory agents,...
Complex Regional Pain Syndrome Type 1 (Reflex Sympathetic Dystrophy) Medication: Sympatholytics, Anti-inflammatory agents,... (medscape.com)
(emedicine.medscape.com)
Calcitonin: Reference Range, Interpretation, Collection and Panels
Calcitonin: Reference Range, Interpretation, Collection and Panels (emedicine.medscape.com)
(emedicine.medscape.com)
(emedicine.medscape.com)
Adhesive Capsulitis in Physical Medicine and Rehabilitation Medication: Endocrine metabolic agents, NSAIDs, Analgesic agents
Adhesive Capsulitis in Physical Medicine and Rehabilitation Medication: Endocrine metabolic agents, NSAIDs, Analgesic agents (emedicine.medscape.com)
Nephrocalcinosis Medication: Diuretics, Thiazide, Calcium Metabolism Modifiers, Vitamins, Antimalarial Agent, Calcimimetic...
Nephrocalcinosis Medication: Diuretics, Thiazide, Calcium Metabolism Modifiers, Vitamins, Antimalarial Agent, Calcimimetic... (emedicine.medscape.com)
(emedicine.medscape.com)