CREST Syndrome
Dermatomyositis
A subacute or chronic inflammatory disease of muscle and skin, marked by proximal muscle weakness and a characteristic skin rash. The illness occurs with approximately equal frequency in children and adults. The skin lesions usually take the form of a purplish rash (or less often an exfoliative dermatitis) involving the nose, cheeks, forehead, upper trunk, and arms. The disease is associated with a complement mediated intramuscular microangiopathy, leading to loss of capillaries, muscle ischemia, muscle-fiber necrosis, and perifascicular atrophy. The childhood form of this disease tends to evolve into a systemic vasculitis. Dermatomyositis may occur in association with malignant neoplasms. (From Adams et al., Principles of Neurology, 6th ed, pp1405-6)
Hyperphosphatemia
N-Acetylgalactosaminyltransferases
Scleroderma, Systemic
A chronic multi-system disorder of CONNECTIVE TISSUE. It is characterized by SCLEROSIS in the SKIN, the LUNGS, the HEART, the GASTROINTESTINAL TRACT, the KIDNEYS, and the MUSCULOSKELETAL SYSTEM. Other important features include diseased small BLOOD VESSELS and AUTOANTIBODIES. The disorder is named for its most prominent feature (hard skin), and classified into subsets by the extent of skin thickening: LIMITED SCLERODERMA and DIFFUSE SCLERODERMA.
Calciphylaxis
Telangiectasis
Hyperostosis, Cortical, Congenital
Calcium Gluconate
Nadroparin
Calcium Pyrophosphate
Nephrocalcinosis
Durapatite
alpha-2-HS-Glycoprotein
Basal Ganglia Diseases
Diseases of the BASAL GANGLIA including the PUTAMEN; GLOBUS PALLIDUS; claustrum; AMYGDALA; and CAUDATE NUCLEUS. DYSKINESIAS (most notably involuntary movements and alterations of the rate of movement) represent the primary clinical manifestations of these disorders. Common etiologies include CEREBROVASCULAR DISORDERS; NEURODEGENERATIVE DISEASES; and CRANIOCEREBRAL TRAUMA.
Raynaud Disease
Fibroblast Growth Factors
A family of small polypeptide growth factors that share several common features including a strong affinity for HEPARIN, and a central barrel-shaped core region of 140 amino acids that is highly homologous between family members. Although originally studied as proteins that stimulate the growth of fibroblasts this distinction is no longer a requirement for membership in the fibroblast growth factor family.
Cardiomyopathies
A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classified according to their predominant pathophysiological features (DILATED CARDIOMYOPATHY; HYPERTROPHIC CARDIOMYOPATHY; RESTRICTIVE CARDIOMYOPATHY) or their etiological/pathological factors (CARDIOMYOPATHY, ALCOHOLIC; ENDOCARDIAL FIBROELASTOSIS).
Antibodies, Antinuclear
Autoantibodies directed against various nuclear antigens including DNA, RNA, histones, acidic nuclear proteins, or complexes of these molecular elements. Antinuclear antibodies are found in systemic autoimmune diseases including systemic lupus erythematosus, Sjogren's syndrome, scleroderma, polymyositis, and mixed connective tissue disease.
Phosphorus
Centromere
Osteopontin
Autoantibodies
Skin
Biopsy
Calcium
A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.
Kidney Failure, Chronic
The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION.
Cutis Laxa
A group of connective tissue diseases in which skin hangs in loose pendulous folds. It is believed to be associated with decreased elastic tissue formation as well as an abnormality in elastin formation. Cutis laxa is usually a genetic disease, but acquired cases have been reported. (From Dorland, 27th ed)
Glycodeoxycholic Acid
Terminology as Topic
Urology
Prostatism
Prostatic Hyperplasia
Lower Urinary Tract Symptoms
Symptoms of disorders of the lower urinary tract including frequency, NOCTURIA; urgency, incomplete voiding, and URINARY INCONTINENCE. They are often associated with OVERACTIVE BLADDER; URINARY INCOMPETENCE; and INTERSTITIAL CYSTITIS. Lower urinary tract symptoms in males were traditionally called PROSTATISM.
Urination Disorders
Lung Compliance
The capability of the LUNGS to distend under pressure as measured by pulmonary volume change per unit pressure change. While not a complete description of the pressure-volume properties of the lung, it is nevertheless useful in practice as a measure of the comparative stiffness of the lung. (From Best & Taylor's Physiological Basis of Medical Practice, 12th ed, p562)
Scleroderma, Localized
Respiratory Function Tests
Broncholithiasis: rare but still present. (1/3283)
Broncholithiasis is a rare but distinct and potentially dangerous pulmonary problem that still needs to be considered in the differential diagnosis of some patients with bronchial obstruction. Broncholiths originate from calcified material in peribronchial lymph nodes eroding into the tracheobronchial tree. The clinical and chest X-ray signs are usually non-specific, but the diagnosis can nowadays be made based on clinical suspicion, CT-scan and fibre-optic bronchoscopy findings, so that a malignant cause of airway obstruction can be ruled out. The removal of broncholiths during fibre-optic bronchoscopy is seldom possible and rather dangerous. They can be removed safely by rigid bronchoscopy with the aid of Nd-YAG laser photocoagulation. Thoracotomy is indicated in complicated cases with fistula formation or severe bleeding. (+info)Role of glutaraldehyde in calcification of porcine aortic valve fibroblasts. (2/3283)
Glutaraldehyde-treated porcine aortic valve xenografts frequently fail due to calcification. Calcification in the prostheses begins intracellularly. In a previous study, various types of cell injury to canine valvular fibroblasts, including glutaraldehyde treatment, led to calcification. An influx of extracellular Ca2+ into the phosphate-rich cytosol was theorized to be the mechanism of calcification. To test the Ca2+ influx theory, cytosolic Ca2+ and Pi concentrations were assessed in glutaraldehyde-treated porcine aortic valve fibroblasts, and their relationship to a subsequent calcification was studied. Glutaraldehyde caused an immediate and sustained massive cytosolic Ca2+ increase that was dose dependent and a several-fold increase in Pi. Calcification of cells followed within a week. The earliest calcification was observed in blebs formed on glutaraldehyde-treated cells. Live control cells or cells fixed with glutaraldehyde in Ca2+-free solution did not calcify under the same conditions. Concomitant increases in Ca2+ and Pi in glutaraldehyde-treated cells appear to underlie the mechanism of calcification, and the presence of extracellular Ca2+ during glutaraldehyde fixation promotes calcification. (+info)Histology and tissue chemistry of tidemark separation in hamsters. (3/3283)
Adult articular cartilage is divided by the tidemark into a deep calcified layer and a more superficial uncalcified layer. Histologic examination of articular cartilage from the knee joint of golden Syrian hamsters 123 days of age or older revealed defects at the tidemark in the tibia. Defects ranged from small separations of the calcified and uncalcified layers along the tidemark to progressively larger defects apparently formed by dissolution. These larger defects appeared as cavities in the noncalcified cartilage, had smooth rather than rough edges, frequently contained coalesced debris, and often resulted in a bulge in the articular surface. Occasionally, these large defects broke through the articular surface. Defects were not observed in tibial cartilage of younger (<90 days old) hamsters or in femoral cartilage from hamsters of any age. Exercise neither protected against nor increased the severity of the defects. Collagen cross-linking by pyridinoline was examined as a function of age and increased from 1,090 to 3,062 micromoles of pyridinoline/mole of hydroxyproline over the period of 1-9 months of age but was not correlated with defect formation. With increasing age, these focal tidemark defects could lead to osteoarthrosis-like cartilage lesions. (+info)Incidence and clinical relevance of coronary calcification detected by electron beam computed tomography in heart transplant recipients. (4/3283)
BACKGROUND: Patients treated by cardiac transplantation who survive beyond one year are at significant risk from fatal coronary artery disease. The development of coronary artery calcification in these patients is discussed and methods available to detect it are reviewed. OBJECTIVES: To assess the clinical importance of coronary artery calcium in heart transplant recipients. METHODS: In a cohort of 102 cardiac transplant recipients, electron beam computed tomography was used to measure calcium in the coronary arterial wall 63 days to 9.1 years (median 4.6 years) after transplantation. The results were compared with angiographic findings and with conventional coronary disease risk factors. The patients were followed for a mean of 2.12 years (1.2-4.02 years) to assess the relationship between these findings and future cardiac events. RESULTS: Forty-one (40.2%) had a stenosis of > 24% in one or more major coronary artery at angiography. Forty-six (45%) had a coronary calcium score > 0. The absence of calcium had a negative predictive value with respect to angiographic disease in any vessels of 87.5%. Logistic regression revealed that dyslipidaemia, systemic hypertension and organ ischaemic time were significant predictors of calcification. At follow-up, both an abnormal coronary angiogram and coronary calcium were found to be the only significant predictors of late events. Multivariate analysis suggested that the detection of coronary calcium did not offer any additional predictive information over that provided by the angiogram itself. CONCLUSION: Electron beam computed tomography is well suited to the assessment of calcium in the coronary arteries of heart transplant recipients, although the mechanisms of this calcification remain poorly understood. Calcium is detected more frequently than would be suggested by studies using intravascular ultrasound. It is associated with the presence of angiographic disease, and with some conventional risk factors for coronary disease. At follow-up the presence of coronary calcium was associated with an adverse clinical outcome, as it is in conventional ischaemic heart disease. (+info)Renal biopsy in the milk-alkali syndrome. (5/3283)
In milk-alkali syndrome the degree of renal impairment varies greatly. Few reports have been published describing structural changes on renal biopsy. In three illustrative cases, impairment of renal function was related to morphological changes shown on percutaneous biopsy. Milk-alkali syndrome should be considered as a cause of renal dysfunction in patients with a long history of dyspensia. (+info)Degenerative changes in aortic root allografts placed in the right ventricular outflow tract of growing puppies. (6/3283)
Differently prepared aortic root allografts were implanted in the right ventricular outflow tract of growing puppies to determine the site of origin and progress of degenerative changes in these conduits. The three preparations assessed were as follows: group A, fresh and sterile grafts; group B, antibiotic sterilized grafts in nutrient medium; and group C, beta-propiolactone sterilized grafts. Although calcification of the aortic wall occurred in all groups, the aortic leaflets were minimally affected. A correlation between viability and lack of calcification and between viability and long-term function is emphasized. (+info)Calcific myonecrosis. (7/3283)
Calcific myonecrosis is a rare and late sequela of compartment syndrome, which becomes symptomatic years after the initial trauma. We diagnosed this condition in a 64-year old man, 42 years after he sustained a shot-gun wound to the right lower leg. Total excision of a peripherally calcified, cystic mass, continuous with the anterior tibial muscle belly resulted in complete resolution of symptoms. Consideration of the diagnosis is warranted in patients with a history of major injury who develop a soft tissue mass in the traumatized compartment. The treatment of choice is marginal excision. (+info)Angiographic correlation of CT calcification in the carotid siphon. (8/3283)
BACKGROUND AND PURPOSE: Calcification in the coronary arteries has been correlated with significant vessel stenosis. The predictive value of calcification within the carotid siphon has not been characterized; however, stenosis in the carotid siphon is potentially important in determining management of patients with ipsilateral carotid bifurcation stenosis. The purpose of this study was to determine optimal parameters for assessing carotid siphon calcification on head CT scans and to compare the CT findings with angiographic results. METHODS: We performed a retrospective review of patients referred for diagnostic carotid arteriography. Those patients who also had undergone a head CT study at our institution were selected. The CT scans and angiograms of 64 patients (128 vessels) were reviewed. Carotid siphon calcification on CT scans was characterized on brain and bone windows as mild, moderate, or severe. Comparison was then made with angiographic findings. RESULTS: The sensitivity and specificity of CT for depicting greater than 50% angiographic stenosis in the carotid siphon were 86% and 98%, respectively, for bone windows and 100% and 0%, respectively, for brain windows. The positive predictive value (PPV) for a stenosis of greater than 50% as evidenced by severe calcification was 86% on bone windows and 11% on brain windows. The PPV for mild and moderate calcification on bone windows was 2.5% and 0%, respectively. CONCLUSION: Severe CT calcification in the carotid siphon as characterized on bone windows correlates with a carotid siphon stenosis of greater than 50% as determined angiographically. Therefore, the identification of severe calcification offers a potential noninvasive method for identifying stenosis of the carotid siphon. This information may be essential in determining management and prognosis for patients with carotid bifurcation stenosis. (+info)
Dystrophic calcification - Wikipedia
Dystrophic calcification synonyms, dystrophic calcification antonyms - FreeThesaurus.com
Background Dystrophic calcifications may occur in patients with J uvenile Idiopathic | PARP inhibitor BMN-673 targeting of the...
Targeting of the osteoclastogenic RANKL-RANK axis prevents osteoporotic bone loss and soft tissue calcification in...
Calcinosis Cutis (Benign Cutaneous Calcification, Benign Nodular Calcification) - Clinical Advisor
Hyperphosphatemic Familial Tumoral Calcinosis, Fgf23-Related disease: Malacards - Research Articles, Drugs, Genes, Clinical...
Association of mitral annulus calcification, aortic valve calcification with carotid intima media thickness | Cardiovascular...
Pathogenesis of Calcific Aortic Valve Disease | Arteriosclerosis, Thrombosis, and Vascular Biology
Radiopacities in soft tissue on dental radiographs: Diagnostic considerations
Coronary artery calcification | Article about coronary artery calcification by The Free Dictionary
IJMS | Free Full-Text | Atherosclerotic Calcification Detection: A Comparative Study of Carotid Ultrasound and Cone Beam CT
mediaTUM - Media and Publication Server
Patent US6205236 - Method and system for automated detection of clustered microcalcifications ... - Google Patents
Nutrients | Free Full-Text | High-Dose Menaquinone-7 Supplementation Reduces Cardiovascular Calcification in a Murine Model of...
Abstract 452: Longitudinal Visualization of Calcification Genesis and Growth in vivo: Novel Implications for Plaque...
Intracellular accumulation
Siblings with multiple soft tissue calcifications | Postgraduate Medical Journal
Breast calcifications biopsy
Spotty Calcification Typifies the Culprit Plaque in Patients With Acute Myocardial Infarction | Circulation
Value of Oral Phytate (InsP6) in the Prevention of Progression of the Cardiovascular Calcifications
Significance of a positive family history for coronary heart disease in patients with a zero coronary artery calcium score ...
Genetic Associations with Valvular Calcification and Aortic Stenosis | Lund University Diabetes Centre
Mahidol Universitys Institutional Repository (Mahidol IR): Abdominal aorta and pelvic artery calcifications on plain...
Raman spectroscopy imaging reveals interplay between atherosclerosis and medial calcification in the human aorta | Science...
Breast arterial calcification strong predictor of coronary artery calcification | EurekAlert! Science News
Abstract 3489: Presence of Thoracic Aorta Calcification Predicts All Cause Mortality Independent of Traditional Cardiovascular...
Ventricular Size and Value Calcification Measures by Computed Tomography - Ancillary to MESA - Full Text View - ClinicalTrials...
Ventricular Size and Value Calcification Measures by Computed Tomography - Ancillary to MESA - Full Text View - ClinicalTrials...
Calcinosis cutis: Etiology and patient evaluation
calcium deposit on heart at 20 weeks
CT Coronary Artery Calcification and Diabetes | Phoenix Cardiology
Top Coronary Artery Calcification Hospitals in Thane | Credihealth
Coronary Calcification and Coronary Atherosclerosis: Site by Site Comparative Morphologic Study of Electron Beam Computed...
CALCINOSIS CUTIS TREATMENT PDF
Relationship of bone mineral density with valvular and annular calcification in community-dwelling older people: The...
Influence of Coronary Calcification on the Diagnostic Performance of CT Angiography Derived FFR in Coronary Artery Disease |...
Idiopathic infantile arterial calcification - Wikipedia
Omega Research
Effects of pixel size on classification of microcalcifications on digitized mammograms | (1996) | Chan | Publications | Spie
SciCombinator - Fibroblast growth factor 23 is associated with carotid artery calcification in chronic kidney disease patients...
Rocaltrol Medical Professional Page
Rocaltrol Medical Professional Page
Open Access Journals
How can cardiac calcification be treated? - The Chart - CNN.com Blogs
How can cardiac calcification be treated? - The Chart - CNN.com Blogs
Retrospective Study of Seven Patients with Tumoral Calcinosis - Journal of Bone & Soft Tissue Tumors
Higher Ambulatory Blood Pressure Is Associated With Aortic Valve Calcification in the Elderly: A Population-Based Study |...
IMPACT OF AORTIC VALVE CALCIFICATION AND SEX ON HEMODYNAMIC PROGRESSION AND CLINICAL OUTCOMES IN AORTIC STENOSIS | JACC:...
Apocrine cystic calcinosis | definition of apocrine cystic calcinosis by Medical dictionary
Aortic Valve Calcification and the Risk of dementia: A Population-Based Study | Meta
JCI -
Usage information: Autoimmune hyperphosphatemic tumoral calcinosis in a patient with FGF23 autoantibodies
JCI -
Autoimmune hyperphosphatemic tumoral calcinosis in a patient with FGF23 autoantibodies
Abdominal aortic calcifications predict survival in peritoneal dialysis patients - Research Portal, Aalborg University
eCite - Association of epicardial fat, hypertension, subclinical coronary artery disease, and metabolic syndrome with left...
Valve Interstitial Cells: The Key to Understanding the Pathophysiology of Heart Valve Calcification | Journal of the American...
Very low density lipoprotein cholesterol associates with coronary artery calcification in type 2 diabetes beyond circulating...
Activation of AKT by O-Linked N-Acetylglucosamine Induces Vascular Calcification in Diabetes MellitusNovelty and Significance |...
Diagnostic Radiology/Musculoskeletal Imaging/Joint Disorders/Scleroderma - Wikibooks, open books for an open world
Arterial calcification, generalised, of infancy type 2 | definition of arterial calcification, generalised, of infancy type 2...
Sabinet | CT brain demonstration of basal ganglion calcification in adult HIV / AIDS patients : original article
Impact of Aortic Valve Calcification Measured by Multidetector Computed Tomography on Survival in Patients With Aortic Stenosis...
Basal ganglia calcification, idiopathic, 3
Coronary Artery Calcium Score, Distribution, and Future Revascularization | JACC: Cardiovascular Imaging
Dystrophic Calcinosis Cutis: a rare fearsome issue of Chronic Kidney Disease - GIN
Aortic calcification and aneurysm in Moscow Lung Cancer Screening. - RadiologyStudy
Coffee lowers risk of cardiovascular disease
High coronary calcium score and post-procedural CK-MB are noninvasive | CIA
Smooth Muscle Cells Give Rise to Osteochondrogenic Precursors and Chondrocytes in Calcifying Arteries | Circulation Research
Inhibition of Bone Morphogenetic Protein Signal Transduction Prevents the Medial Vascular Calcification Associated with Matrix...
Physiological intracranial calcification: Definition with Physiological intracranial calcification Pictures and Photos
Ethnic Differences in the Prognostic Value of Coronary Artery Calcification for All-Cause Mortality<...
北京大学医学部机构知识库([email protected]): Homocysteine potentiates calcification of cultured rat aortic smooth muscle cells
Association of serum phosphorus, calcium and parathyroid hormone with cardiovascular calcification in regular hemodialysis...
Cardiovascular Calcification And Bone Mineralization - Aikawa Elena (Curatore); Hutcheson Joshua D. (Curatore) | Libro Humana ...
Lipoprotein(a) levels are associated with aortic valve calcification in asymptomatic patients with familial...
Oral administration of pyrophosphate inhibits connective tissue calcification | EMBO Molecular Medicine
Bisphosphonates: pharmacology and use in the treatment of tumour-induced hypercalcaemic and metastatic bone disease
Mouse Samd9l is not a functional paralogue of the human SAMD9, the gen by Qiaoli Li, Haitao Guo et al.
Click to print
X-ray of shoulder joint, calcification of tendon. - Stock Image M110/0347 - Science Photo Library
em|In vivo|/em| efficacy of a pharmacological inhibitor of TNAP to prevent arterial calcification and its associated cardiac...
Calciphylaxis - What Do We Know? - AJKD Blog
Association Between Mitral Annulus Calcification and Carotid Atherosclerotic Disease | Stroke
Coffee consumption and coronary artery calcium in young and middle-aged asymptomatic adults
Acute changes in inorganic phosphorus, urea, and alkaline phosphatase by Y Hamuro
Human Metabolome Database: Showing metabocard for beta-nicotinamide D-ribonucleotide (HMDB0059645)
Idiopathic infantile arterial calcification in two siblings: failure of treatment with diphosphonate. | Heart
Calcium deposits in veins - Things You Didnt Know
bims-mibica 2021-01-10 papers
Vascular Calcifications: Pathogenesis, Management, and Impact on Clinical Outcomes | American Society of Nephrology
Patent US20080251868 - Standard component for calibration and electron-beam system using the same - Google Patents
Circulating Neutrophils Do Not Predict Subclinical Coronary Artery Disease in Women With Former Preeclampsia - PubMed
Joseph Harold Sheldon
with Wilfrid Sheldon: Sheldon, J. H.; Sheldon, W. (March 1936). "Arterial Calcification and Subcutaneous Calcinosis in a boy ... Arterial Calcification and Subcutaneous Calcinosis: Case shown in January, 1936". Proc R Soc Med. 31 (9): 1119-1120. doi: ... Sheldon, J. H. (April 1934). "Calcinosis Universalis". Proc R Soc Med. 27 (6): 623-626. doi:10.1177/003591573402700601. PMC ...
Hypercalcaemia
Enzootic Calcinosis Archived 2014-07-28 at the Wayback Machine Gruenberg MS, PhD, DECAR DECBHM. W.G., April 2014. Enzootic ... Calcinosis. The Merck Veternary Manual. Merck Sharp & Dohme, Whitehouse Station, NJ, USA. Topical Agents (Toxicity) Archived ...
List of OMIM disorder codes
TSC2 Tumoral calcinosis, familial, normophosphatemic; 610455; SAMD9 Tumoral calcinosis, hyperphosphatemic; 211900; KL Tumoral ... calcinosis, hyperphosphatemic, familial; 211900; FGF23 Tumoral calcinosis, hyperphosphatemic, familial; 211900; GALNT3 Tyrosine ...
Calcium pyrophosphate dihydrate crystal deposition disease
"calcinosis_cutis_2_060122". Derm Atlas. Archived from the original on 5 February 2007. Retrieved 13 March 2012. "Calcium ...
Dystrophic calcification
Calcinosis cutis is condition in which there are irregular nodular deposits of calcium salts in skin and subcutaneous tissue. ... Calcinosis Monckeberg's arteriosclerosis "Cell Injury". CS1 maint: discouraged parameter (link) Bertazzo, Sergio; Gentleman, ...
Progeroid syndromes
... calcinosis (calcium deposits in blood vessels); atherosclerosis (blockage of blood vessels); type 2 diabetes; loss of bone mass ...
Hypervitaminosis A
"Gastric mucosal calcinosis: clinicopathologic considerations" (PDF). Advances in Anatomic Pathology. 14 (3): 224-8. doi:10.1097 ... Drowsiness Headache Gastric mucosal calcinosis Heart valve calcification Hypercalcemia Increased intracranial pressure ...
Fiddler's neck
Dystrophic calcinosis cutis has also been reported. Other serious sequelae include sialolithiasis of the submandibular gland ... Oga, A.; Kadowaki, T.; Hamanaka, S.; Sasaki, K. (1998). "Dystrophic calcinosis cutis in the skin below the mandible of a ...
Calcification
Monckeberg's arteriosclerosis Pineal gland Calcinosis Bertazzo, Sergio; Gentleman, Eileen; Cloyd, Kristy L.; Chester, Adrian H ...
SAMD9
Dereure O (May 2007). "[SAMD9 mutation in normophosphatemic familial tumoral calcinosis]". Annales de Dermatologie et de ... "A deleterious mutation in SAMD9 causes normophosphatemic familial tumoral calcinosis". American Journal of Human Genetics. 79 ( ...
Isotretinoin
The compound 13-cis retinoic acid was first studied in the 1960s at Roche Laboratories in Switzerland by Werner Bollag as a treatment for skin cancer. Experiments completed in 1971 showed that the compound was likely to be ineffective for cancer and, surprisingly, that it could be useful to treat acne. However, they also showed that the compound was likely to cause birth defects, so in light of the events around thalidomide, Roche abandoned the product. In 1975, Gary Peck and Frank Yoder independently rediscovered the drug's use as a treatment of cystic acne while studying it as a treatment for lamellar ichthyosis, and published that work. Roche resumed work on the drug. In clinical trials, subjects were carefully screened to avoid including women who were or might become pregnant. Roche's New Drug Application for isotretinoin for the treatment of acne included data showing that the drug caused birth defects in rabbits. The FDA approved the application in 1982. Scientists involved in the ...
GALNT3
2007). "Tumoral calcinosis presenting with eyelid calcifications due to novel missense mutations in the glycosyl transferase ... 2006). "Polypeptide GalNAc-transferase T3 and familial tumoral calcinosis. Secretion of fibroblast growth factor 23 requires O- ... cause familial tumoral calcinosis". Nat Genet. 36 (6): 579-81. doi:10.1038/ng1358. PMID 15133511. "Entrez Gene: GALNT3 UDP-N- ... "Two novel nonsense mutations in GALNT3 gene are responsible for familial tumoral calcinosis". J. Hum. Genet. 52 (5): 464-8. doi ...
Subepidermal calcified nodule
Lesions may also appear on the ear and eyelid.[citation needed] Ectopic calcification Calcinosis cutis Skin lesion List of ... Subepidermal calcified nodule is a type of Calcinosis cutis. It's a cutaneous condition characterized by calcification of the ...
Primrose syndrome
Calcinosis Fahr's syndrome Muscular atrophy "OMIM Entry - # 259050 - PRIMROSE SYNDROME; PRIMS". omim.org. Retrieved 6 August ...
Primary familial brain calcification
Bonazza S, La Morgia C, Martinelli P, Capellari S (August 2011). "Strio-pallido-dentate calcinosis: a diagnostic approach in ... Loeb JA (March 1998). "Functional improvement in a patient with cerebral calcinosis using a bisphosphonate". Mov. Disord. 13 (2 ...
Nicholas Theodore
Kalani, MY; Martirosyan, NL; Little, AS; Kakarla, UK; Theodore, N (Dec 2011). "Tumoral calcinosis presenting as a deformity of ...
Shapiro-Senapathy algorithm
Identification of Familial tumoral calcinosis (FTC) is an autosomal recessive disorder characterized by ectopic calcifications ... "An FGF23 missense mutation causes familial tumoral calcinosis with hyperphosphatemia". Human Molecular Genetics. 14 (3): 385- ...
Juvenile dermatomyositis
Some children develop calcinosis, which are calcium deposits under the skin. The rash is the source of the "dermato-" part of ... calcinosis and neopterin. Once a diagnosis of JDMS is made, the treatment is often a 3-day course of Intravenous ("pulse") ... calcinosis, dysphonia and nailfold capillaroscopy. Other useful criteria include myositis-specific or -related antibodies, ...
Trisetum flavescens
2000). Enzootic calcinosis in 16 cows from 6 dairy farms in Unterengadin. Schweiz Arch Tierheilkd. 142:6 333-8. Braun, U., et ... 2000). Enzootic calcinosis in goats caused by golden oat grass (Trisetum flavescens). Veterinary Record 146 161-2. Grabner, A ... 1985). Enzootic calcinosis in the horse. Tierarztl Prax Suppl. 1 84-93. Ess. Agrostogr. 88, 153. 1812 GrassBase entry: Trisetum ... This grass is noted for being toxic to livestock, causing calcinosis, the deposition of calcium in soft tissues including ...
American lobster
Excretory calcinosis in American lobsters in Long Island Sound was described in 2002. The disease causes mineralized calculi to ... A. D. Dove; C. LoBue; P. Bowser; M. Powell (2004). "Excretory calcinosis: a new fatal disease of wild American lobsters Homarus ... A. D. M. Dove (2005). "Ultrastructural features of excretory calcinosis in the lobster, Homarus americanus Milne-Edwards". ...
Esophageal motility disorder
... may be a result of CREST syndrome, referring to the five main features: calcinosis, Raynaud ... and subcutaneous calcinosis: a syndrome mimicking hereditary hemorrhagic telangiectasia". Bulletin of the Johns Hopkins ...
CREST syndrome
CREST causes thickening and tightening of the skin with deposition of calcific nodules ("calcinosis"). Raynaud's phenomenon is ... The acronym "CREST" refers to the five main features: calcinosis, Raynaud's phenomenon, esophageal dysmotility, sclerodactyly, ... Winterbauer RH (1964). "Multiple telangiectasia, Raynaud's phenomenon, sclerodactyly, and subcutanious calcinosis: a syndrome ...
Osteoma cutis
Calcinosis cutis Skin lesion List of cutaneous conditions "OMIM Entry - # 166350 - OSSEOUS HETEROPLASIA, PROGRESSIVE; POH". ...
Systemic scleroderma
Calcinosis (deposition of calcium in lumps under the skin) is also common in systemic scleroderma, and is often seen near the ... Joint mobility, especially of the small joints of the hand, may be restricted by calcinosis or skin thickening. Patients may ... Calcinosis, Raynaud's phenomenon, Esophageal dysfunction, Sclerodactyly, and Telangiectasia (CREST syndrome) are associated ...
Hypervitaminosis A
Gorospe M, Fadare O (May 2007). "Gastric mucosal calcinosis: clinicopathologic considerations". Advances in Anatomic Pathology ...
Reynolds syndrome
Typical clinical features include jaundice, elevated blood levels of alkaline phosphatase, calcinosis cutis, telangiectasias, ...
Robert Harold Wasserman
This plant is common to South American countries, where calcinosis, including tissue calcification, and associated pathology, ... "Hypercalcemia and calcinosis in Florida horses: implication of the shrub, Cestrum diurnum, as the causative agent". The Cornell ...
Telangiectasia
The syndrome recognises the significantly co-presenting symptoms of calcinosis, Raynaud's phenomenon, esophageal dysmotility, ...
Calcinosis - Wikipedia
Calcinosis is the formation of calcium deposits in any soft tissue. It is a rare condition that has many different causes. ... The most common type of calcinosis is dystrophic calcification. This type of calcification can occur as a response to any soft ... The cause of the rare condition of tumoral calcinosis is not entirely understood. It is generally characterized by large, ... Calcification Calcinosis cutis Dermatomyositis Fahrs syndrome Hyperphosphatemia Primrose syndrome Scleroderma Media related to ...
Tumoral calcinosis - Wikipedia
... indicating an evolutionary conserved mechanism that is involved in developing tumoral calcinosis. The name indicates calcinosis ... Tumoral calcinosis is a rare condition in which there is calcium deposition in the soft tissue in periarticular location, ... Clinically also known as hyperphosphatemic familial tumoral calcinosis (HFTC), is often caused by genetic mutations in genes ... Genetests/NCBI/NIH/UW entries on Hyperphosphatemic Familial Tumoral Calcinosis. ...
Hyperphosphatemic familial tumoral calcinosis: MedlinePlus Genetics
... calcinosis) in the bodys tissues. Explore symptoms, inheritance, genetics of this condition. ... Hyperphosphatemic familial tumoral calcinosis (HFTC) is a condition characterized by an increase in the levels of phosphate in ... Calcinosis may also develop in the soft tissue of the feet, legs, and hands. Rarely, calcinosis occurs in blood vessels or in ... Genetic Testing Registry: Hyperphosphatemic familial tumoral calcinosis 3 *Genetic Testing Registry: TUMORAL CALCINOSIS, ...
Calcinosis Cutis Differential Diagnoses
Calcinosis cutis is a term used to describe a group of disorders in which calcium deposits form in the skin. Virchow initially ... encoded search term (Calcinosis Cutis) and Calcinosis Cutis What to Read Next on Medscape ... Calcinosis Cutis Differential Diagnoses. Updated: Mar 05, 2020 * Author: Julia R Nunley, MD; Chief Editor: Dirk M Elston, MD ... Calcinosis cutis: an additional therapy to consider. J Am Acad Dermatol. 2012 Jun. 66(6):1004-5; author reply 1005. [Medline]. ...
Calcinosis - definition of calcinosis by The Free Dictionary
calcinosis synonyms, calcinosis pronunciation, calcinosis translation, English dictionary definition of calcinosis. n. An ... Related to calcinosis: calcinosis circumscripta, Calcinosis cutis, tumoral calcinosis. cal·ci·no·sis. (kăl′sə-nō′sĭs). n.. An ... calcinosis. n calcinosis f. English-Spanish/Spanish-English Medical Dictionary Copyright © 2006 by The McGraw-Hill Companies, ... Tumoral calcinosis in infants: a report of three cases and review of the literature.. Selim kalsinozis kutis/Benign calcinosis ...
Calcinosis cutis: Etiology and patient evaluation
Based upon the etiology of calcium deposition, there are five subtypes of calcinosis cutis: dystrophic, metastatic, idiopat ... Calcinosis cutis is a descriptive term for the deposition of insoluble calcium salts in the cutaneous and subcutaneous tissue. ... Idiopathic calcinosis cutis: Idiopathic calcinosis cutis is the occurrence of calcinosis cutis without any underlying tissue ... Iatrogenic calcinosis cutis: Iatrogenic calcinosis cutis is the deposition of calcium salts in the skin as a side effect of ...
Idiopathic Scrotal Calcinosis - American Urological Association
Scleroderma with calcinosis
... By Stephanie Eschenbach, MD and Thomas L. Pope, Jr., MD, FACR ... 2 Subcutaneous calcinosis, as part of the CREST variant or diffuse variant, is often seen on the extensor surfaces and in areas ... subcutaneous calcinosis on the left thumb volar pad; 5) moderate-to-severe resorption of the right first-, second-, and third- ... "7 The combination of calcinosis and acro-osteolysis, as seen in Figure 2, is considered to be pathognomic for scleroderma.6 ...
JCI -
Autoimmune hyperphosphatemic tumoral calcinosis in a patient with FGF23 autoantibodies
We present what we believe is the first identified case of autoimmune hyperphosphatemic tumoral calcinosis in an 8-year-old boy ... Hyperphosphatemic familial tumoral calcinosis (HFTC)/hyperostosis-hyperphosphatemia syndrome (HHS) is an autosomal recessive ... In addition to the classical clinical and biochemical features of hyperphosphatemic tumoral calcinosis, the patient exhibited ... Thus, this report describes the first case, to our knowledge, of autoimmune hyperphosphatemic tumoral calcinosis with ...
Evaluation of Calcinosis in Systemic Sclerosis - Full Text View - ClinicalTrials.gov
Evaluation of Calcinosis Prevalence in Systemic Sclerosis : a Cross Sectional Study Evaluating Calcinosis Cutis Prevalence by ... Evaluation of Calcinosis in Systemic Sclerosis (CALCIDERMIS). The safety and scientific validity of this study is the ... Calcinosis cutis prevalence by radiographic assessment [ Time Frame: at inclusion ( baseline) ]. Secondary Outcome Measures : * ... Calcinosis. Pathologic Processes. Connective Tissue Diseases. Skin Diseases. Calcium Metabolism Disorders. Metabolic Diseases. ...
Orphanet: Bilateral striopallidodentate calcinosis
Browsing by Subject "Calcinosis"
hyperphosphatemic familial tumoral calcinosis Disease Ontology Browser - DOID:0111063
... primary hyperphosphatemic tumoral calcinosis; tumoral calcinosis with hyperphosphatemia ... Synonyms: cortical hyperostosis with hyperphosphatemia; familial hyperphosphatemic tumoral calcinosis/hyperphosphatemic ... hyperostosis syndrome; familial Teutschlaender disease; HFTC; HHS; hypercalcemic tumoral calcinosis; hyperostosis with ... tumoral calcinosis with hyperphosphatemia Alt IDs: OMIM:211900, ICD10CM:M11.2, ORDO:306661 Definition: A calcinosis ...
Scrotal Calcinosis: A Case Report and Review of Pathogenesis and Surgical Management
V. Mehta and C. Balachandran, "Idiopathic vulvar calcinosis: the counterpart of idiopathic scrotal calcinosis," Indian Journal ... Scrotal Calcinosis: A Case Report and Review of Pathogenesis and Surgical Management. Usman M. Tela1 and M. Bashir Ibrahim2 ... S. G. Browne, "Calcinosis circumscripta of the scrotal wall, the aetiologic role of onchocerca vulvulus," British Journal of ... C. H. Chang, C. H. Yang, and H. S. Hong, "Surgical pearl: pinch-punch excisions for scrotal calcinosis," Journal of the ...
ISN Photo Repository: Calcinosis on Dime
... calcinosis) on a dime. The calcinosis was removed from a patient who has had systemic sclerosis (scleroderma) for a year. ISN ... Also see Photo of Calcinosis on Fingertip). A year and a half ago, her doctor stopped her Raynauds medication for emotional ... Photo of Calcinosis on Dime. Author: Shelley Ensz. Scleroderma is highly variable. See Types of Scleroderma. Read Disclaimer ... The calcium nodule (calcinosis) is an ugly thing, with lots of irregularities to hang onto flesh. My wife has had scleroderma ...
increased susceptibility to dystrophic cardiac calcinosis Mammalian Phenotype Term (MP:0002839)
The Mammalian Phenotype (MP) Ontology is a community effort to provide standard terms for annotating phenotypic data. You can use this browser to view terms, definitions, and term relationships in a hierarchical display. Links to summary annotated phenotype data at MGI are provided in Term Detail reports.
Calcinosis Circumscripta and Cutis | VCA Animal Hospital
Calcinosis circumscripta is deposition of calcium at bony prominences or, in the footpads and mouth. It is usually a disease of ... Calcinosis cutis is induced by local skin damage in susceptible animals and takes two forms: dystrophic or metastatic. The ... How does calcinosis cutis and calcinosis circumscripta typically progress?. In the case of calcinosis circumscripta, single ... Calcinosis cutis occurs in susceptible pets in areas where local skin damage has occurred. Calcinosis cutis has two forms:. * ...
CALCINOSIS TREATED BY PARATHYROIDECTOMY* | Annals of Internal Medicine | American College of Physicians
CALCINOSIS TREATED BY PARATHYROIDECTOMY1 ELMER C. BARTELS, M.D., F.A.C.P.; RICHARD B. CATTELL, M.D. ... CALCINOSIS AND SCLERODERMA WITH PARATHYROIDECTOMY1 Annals of Internal Medicine; 18 (2): 225-232 ... Subcutaneous calcinosis, a disease tending to serious bodily disability, presents a most difficult therapeutic problem. It is ... Dystrophic calcinosis in a patient with overlap syndrome (scleroderma and rheumatoid arthritis) treated by leflunomide: A case ...
Calcinosis cutis pathology | DermNet NZ
Skin calcinosis pathology, Cutaneous calcification pathology. Authoritative facts from DermNet New Zealand. ... Histology of calcinosis cutis. There are irregular deposits of intensely basophilic acellular material in the dermis and ... The deposition of calcium in the skin, subcutaneous tissue, muscles and visceral organs is known as calcinosis. This condition ... Calcinosis cutis pathology. Author: Dr Ben Tallon, Dermatologist/Dermatopathologist, Tauranga, New Zealand, December 2016. ...
Calcinosis cutis
... Subscriber Sign In VisualDx Mobile Feedback Select Language Share Get VisualDx Mobile. There are VisualDx ... L94.2 - Calcinosis cutis. SNOMEDCT:. 21323007 - Calcinosis cutis. Look For. Subscription Required. Diagnostic Pearls. ... Calcinosis cutis in Infant/Neonate. Print Images (7) Contributors: Noah Craft MD, PhD, Belinda Tan MD, PhD, Lowell A. Goldsmith ... Note, however, that calcinosis cutis can occur anywhere on the body. Local trauma, infections (particularly parasitic, eg, ...
Ulcer and Calcinosis - Sclero Forums (MAIN) - Sclero Forums
... index finger on knuckle which has lead to a calcinosis, (same finger), which has become abscessed on pad, its becoming bigger. ... Not sure what hurts more the ulcer or the calcinosis! :wacko: Well..... even if I slightly bump the calcinosis, or touch it, it ... Ulcer and Calcinosis By Annie20, June 8, 2011. in Sclero Forums (MAIN) ... If I bump or press on the calcinosis, it hurts tremendously. (It has become bigger.) I do not want to subject myself to anymore ...
KALZINOSE (calcinosis): Topics by WorldWideScience.org
Pronounced Linear Calcinosis in a Boy with Mild Dermatomyositis del Carmen Boente, María; Nadra, Graciela; Asial, Raúl et al. ... Calcinosis in Ruminants due to Plant Poisoning: Contributions on the Pathogenesis Acamovic, T.; Stewart, C. S.; Pennycott, T. ... Tumoral Calcinosis and Calciphylaxis After Renal Transplantation Fernandez, E.; Torregrosa, J. V.; Zarraga, S. et al. 1998-01- ... Tumoral Calcinosis Associated With End-Stage Renal Disease: A Case Study Capes, M.; Fox, R. B.; Association of Chiropractic ...
Sodium Thiosulfate for Treatment of Calcinosis Associated With Juvenile and Adult Dermatomyositis - Tabular View -...
... defined as calcinosis involving the torso or 2 extremities) and moderate to severe calcinosis (indicated by a calcinosis ... Calcinosis can be painful and cause disabilities and other problems. Researchers want to learn more about calcinosis to find ... Has moderate to severe calcinosis, defined as having a calcinosis activity visual analogue scale score of greater than or equal ... Improvement of calcinosis lesions, assessed by Calcinosis Assessment Tool, durometry measurements, photography, and imaging ...
Enzootic Calcinosis in Animals - Musculoskeletal System - Merck Veterinary Manual
Learn about the veterinary topic of Enzootic Calcinosis in Animals. Find specific details on this topic and related topics from ... Etiology and Pathogenesis of Enzootic Calcinosis in Animals Known causes of enzootic calcinosis fall into two categories: plant ... Clinical Findings of Enzootic Calcinosis in Animals Enzootic calcinosis is progressive and chronic, extending for weeks or ... Diagnosis of Enzootic Calcinosis in Animals * Presumptive diagnosis is based on history and clinical signs ...
Calcium and Phosphate Metabolism in Tumoral Calcinosis | Annals of Internal Medicine | American College of Physicians
Calcium and Phosphate Metabolism in Tumoral Calcinosis PAUL D. MITNICK, M.D.; STANLEY GOLDFARB, M.D.; EDUARDO SLATOPOLSKY, M.D ... Calcium and Phosphate Metabolism in Tumoral Calcinosis. Ann Intern Med. 1980;92:482-487. doi: 10.7326/0003-4819-92-4-482 ... We have recently seen a patient with tumoral calcinosis, a syndrome comprising hyperphosphatemia, normocalcemia, normal ...
Resolution of iatrogenic calcinosis cutis in a dog through topical application of DMSO
Treating calcinosis cutis via a topical wash with DMSO every other day was effective for the symptoms of calcinosis cutis. ... A dog with calcinosis cutis was treated by topical dimethyl sulfoxide (DMSO) administration, reaching a complete involution of ... For this reason, DMSO is proposed as a topical treatment for the management of calcinosis cutis in dogs. The authors present ... Resolution of iatrogenic calcinosis cutis in a dog through topical application of DMSO. 26 Sep 2018 ...
Calcinosis | Article about Calcinosis by The Free Dictionary
Find out information about Calcinosis. Deposition of calcium salts in the skin, subcutaneous tissue, or other part of the body ... Related to Calcinosis: calcinosis circumscripta, Calcinosis cutis, tumoral calcinosis. calcinosis. [‚kal·sə′nō·səs] (medicine) ... Cutaneous calcinosis or Calcinosis cutis is a skin disease of dogs characterized by dystrophic calcium deposition in dermis and ... La radiografia confirmo la sospecha de extensas areas de calcinosis (Figura 1).. Calcinosis asimetrica en un adulto con ...
Tumoral calcinosis | definition of tumoral calcinosis by Medical dictionary
What is tumoral calcinosis? Meaning of tumoral calcinosis medical term. What does tumoral calcinosis mean? ... Looking for online definition of tumoral calcinosis in the Medical Dictionary? tumoral calcinosis explanation free. ... 2. calcinosis that develops in association with neoplastic conditions. tumoral calcinosis. Oncology A condition characterized ... Spontaneous regression of multiple tumoral calcinosis in a child.. Selim kalsinozis kutis/Benign calcinosis cutis ...
Tumoral calcinosis | Radiology Case | Radiopaedia.org
Calcinosis | Profiles RNS
"Calcinosis" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... This graph shows the total number of publications written about "Calcinosis" by people in this website by year, and whether " ... Below are the most recent publications written about "Calcinosis" by people in Profiles. ...
FamilialCalcificationCircumscriptaDermatomyositisMetastaticHFTCUniversalisSystemicScrotalCutaneousLesionsTermed calcinosis cutisDepositionKnown as calcinosisTreatment of CalcinosisSevereDiagnosisBenignClinicalOccursCalcificationsPathogenesisEtiologyDepositsHyperphosphatemiaFGF23SclerodermaUncommonNodulesDevelop calcinosis cutisIatrogenic calcinosis cutisDystrophic cardiac calcinosisTumoral calcinosis associatedMawdsley Calcinosis QuestionnaireAbstractPatientsCalcium or phosphateEvaluation of CalcinosisSoft tissueRenalSodium thiosulfateDiffuseCommonlySubcutaneous calcinosisDiseases
Familial22
- Hyperphosphatemic familial tumoral calcinosis (HFTC) is a condition characterized by an increase in the levels of phosphate in the blood (hyperphosphatemia) and abnormal deposits of phosphate and calcium (calcinosis) in the body's tissues. (medlineplus.gov)
- Hyperphosphatemic familial tumoral calcinosis (HFTC) is a very rare disorder of phosphate homeostasis resulting from decreased fibroblast growth factor 23 (FGF23) synthesis or activity (1). (thefreedictionary.com)
- To the Editor: Primary familial brain calcification (PFBC) is a rare genetically degenerative disease that is generally characterized by symmetrical, bilateral calcinosis in the basal ganglia, thalamus, dentate nuclei, and other brain regions and mainly manifests with neurological and psychiatric symptoms. (thefreedictionary.com)
- Hyperphosphatemic familial tumoral calcinosis (HFTC)/hyperostosis-hyperphosphatemia syndrome (HHS) is an autosomal recessive disorder of ectopic calcification due to deficiency of or resistance to intact fibroblast growth factor 23 (iFGF23). (jci.org)
- Histologically, lesions display collagen necrobiosis, followed by cyst formation and a foreign-body response with calcification Two forms of tumoral calcinosis have been described: normocalcemic tumoral calcinosis and familial tumoral calcinosis. (nih.gov)
- PubMed is a searchable database of medical literature and lists journal articles that discuss Familial tumoral calcinosis. (nih.gov)
- Hyperphosphatemic Familial Tumoral Calcinosis, Fgf23-Related An important gene associated with Hyperphosphatemic Familial Tumoral Calcinosis, Fgf23-Related is FGF23 (Fibroblast Growth Factor 23). (malacards.org)
- There are three types: familial tumoral calcinosis, subepidermal calcified nodules, and scrotal calcinosis. (statpearls.com)
- Familial tumoral calcinosis is seen in healthy adolescent patients. (statpearls.com)
- 76 Tumoral calcinosis, normophosphatemic, familial: An uncommon, life-threatening disorder characterized by progressive deposition of calcified masses in cutaneous and subcutaneous tissues. (malacards.org)
- An important gene associated with Tumoral Calcinosis, Normophosphatemic, Familial is SAMD9 (Sterile Alpha Motif Domain Containing 9), and among its related pathways/superpathways are Spinal Cord Injury and Glucocorticoid receptor regulatory network . (malacards.org)
- 77 Normophosphatemic familial tumoral calcinosis is a cutaneous disorder characterized by cutaneous. (malacards.org)
- Adams WM et al: Familial tumoral calcinosis: association with cerebral and peripheral aneurysm formation. (statdx.com)
- Slavin RE et al: Familial tumoral calcinosis. (statdx.com)
- Hyperphosphatemic Familial Tumoral Calcinosis (HFTC) and Hyperphosphatemic Hyperostosis Syndrome (HHS) are associated with autosomal recessive mutations in three different genes, FGF23 , GALNT3 and KL , leading to reduced levels of fibroblast growth factor 23 (FGF23) and subsequent clinical effects. (biomedcentral.com)
- Hyperphosphatemic familial tumoral calcinosis (HFTC) is a rare monogenic disorder with disturbances in the hormonal regulation of phosphate levels by FGF23, leading to soft tissue calcifications [ 2 ]. (biomedcentral.com)
- At least 25 mutations in the GALNT3 gene have been found to cause hyperphosphatemic familial tumoral calcinosis (HFTC), a condition characterized by an increase in the levels of phosphate in the blood (hyperphosphatemia) and abnormal deposits of phosphate and calcium (calcinosis) in the body's tissues. (nih.gov)
- Chefetz I, Kohno K, Izumi H, Uitto J, Richard G, Sprecher E. GALNT3, a gene associated with hyperphosphatemic familial tumoral calcinosis, is transcriptionally regulated by extracellular phosphate and modulates matrix metalloproteinase activity. (nih.gov)
- Chefetz I, Sprecher E. Familial tumoral calcinosis and the role of O-glycosylation in the maintenance of phosphate homeostasis. (nih.gov)
- Hyperphosphatemic familial tumoral calcinosis (FGF23, GALNT3 and αKlotho). (nih.gov)
- Clinical variability of familial tumoral calcinosis caused by novel GALNT3 mutations. (nih.gov)
- Sprecher E. Familial tumoral calcinosis: from characterization of a rare phenotype to the pathogenesis of ectopic calcification. (nih.gov)
Calcification11
- The most common type of calcinosis is dystrophic calcification. (wikipedia.org)
- Enzootic calcinosis is a disease complex of ruminants and horses caused by plant poisoning or mineral imbalances and characterized by extensive calcification of soft tissues. (merckvetmanual.com)
- Tumoral calcinosis may be defined as metastatic periarticular calcification that can be found in a wide variety of conditions such as primary hyperthyroidism and connective tissue diseases, as well as an idiopathic form. (thefreedictionary.com)
- Some patients with ACTD may experience calcinosis universalis with widespread calcification of the subcutaneous tissue, muscles, and tendons. (clinicaladvisor.com)
- Dystrophic calcification is the most common cause of calcinosis cutis and is associated with normal laboratory values of calcium and phosphorus. (statpearls.com)
- NFTC shows a striking resemblance to acquired dystrophic calcinosis, in which tissue calcification occurs as a consequence of tissue injury/inflammation. (malacards.org)
- Idiopathic calcification does not involve underlying tissue damage or abnormal laboratory values and includes tumoral calcinosis, subepidermal calcified nodules, and scrotal calcinosis. (statpearls.com)
- Calcinosis cutis-calcification in soft tissue-is a rare benign disease that is separated into the following subtypes: dystrophic, iatrogenic, metastatic, calciphylaxis, and idiopathic. (kjuo.or.kr)
- The feature of calcinosis cutis of the scrotum is generally slowly growing yellowish nodules that consist of calcification with surrounding foreign body-type granulomatous inflammation. (kjuo.or.kr)
- Plain radiography revealed calcinosis universalis in abdomen ( Fig. 1 ), pelvis and thighs, with intramuscular calcification proximal to the distal insertion of vastus medialis ( Fig. 2 ) and generalized osteopenia. (reumatologiaclinica.org)
- Calcinosis in thighs with intramuscular calcification proximal to the distal insertion of the vastus medialis. (reumatologiaclinica.org)
Circumscripta18
- S. G. Browne, "Calcinosis circumscripta of the scrotal wall, the aetiologic role of onchocerca vulvulus," British Journal of Dermatology , vol. 74, pp. 136-140, 1962. (hindawi.com)
- Calcinosis circumscripta is the deposition of calcium usually at bony prominences (i.e., where bone and skin are thinly separated) or in the footpads and mouth. (vcahospitals.com)
- The cause of calcinosis circumscripta is unknown, but there seems to be a genetic or hereditary component. (vcahospitals.com)
- Pets with calcinosis circumscripta usually have a single lesion over a bony prominence or in the mouth, particularly the tongue. (vcahospitals.com)
- How does calcinosis cutis and calcinosis circumscripta typically progress? (vcahospitals.com)
- In the case of calcinosis circumscripta , single lesions due to causes such as trauma can be cured surgically. (vcahospitals.com)
- Recurrence of calcinosis circumscripta after surgery does not tend to occur. (vcahospitals.com)
- characteristic of calcinosis circumscripta. (learningradiology.com)
- The lesion was successfully excised, and histopathology was performed, revealing evidence of both multiple cartilaginous exostoses and calcinosis circumscripta. (ovid.com)
- Additionally, multiple cartilaginous exostoses have not previously been reported to occur in combination with calcinosis circumscripta. (ovid.com)
- The disorder is classified as calcinosis circumscripta if it is limited to an extremity or joint. (statpearls.com)
- Calcinosis cutis circumscripta: treatment with intralesional corticosteroid. (puppy-party.info)
- Deposits elsewhere in the body are known as calcinosis circumscripta. (dailypuppy.com)
- Internal calcinosis circumscripta is diagnosed via X-ray or computed tomography. (dailypuppy.com)
- Calcinosis circumscripta most often affects young large-breed dogs. (dailypuppy.com)
- While calcinosis cutis initially looks like calcinosis circumscripta, it appears on older dogs. (dailypuppy.com)
- Treatment for calcinosis circumscripta consists primarily of surgical removal of the growths. (dailypuppy.com)
- There's good news -- once an affected dog reaches the age of two, he's unlikely to develop new calcinosis circumscripta lumps. (dailypuppy.com)
Dermatomyositis16
- Calcinosis cutis complicating adult-onset dermatomyositis. (medscape.com)
- Calcinosis cutis universalis with joint contractures complicating juvenile dermatomyositis. (medscape.com)
- Valenzuela A, Chung L, Casciola-Rosen L, Fiorentino D. Identification of clinical features and autoantibodies associated with calcinosis in dermatomyositis. (medscape.com)
- Localized calcinosis in juvenile dermatomyositis: Successful treatment with intralesional corticosteroids injection. (thefreedictionary.com)
- Calcinosis, a serious complication of dermatomyositis, involves deposition of calcium (carbonate apatite) in soft tissue, and can result in negative impacts on quality of life and physical function. (centerwatch.com)
- To date, there are no known effective therapies that are approved for the treatment of dermatomyositis-associated calcinosis, and there is no consensus within the medical community on the optimum treatment strategy for this often-debilitating condition. (centerwatch.com)
- In order to gather more robust data on the utility of this medication in the treatment of calcinosis associated with adult and juvenile dermatomyositis, we propose to evaluate its effects in the context of a prospective clinical trial. (centerwatch.com)
- We plan to enroll participants at a single center into a single-arm, open-label study, with the overall objective of evaluating the efficacy and safety of intravenous sodium thiosulfate use in patients with moderate to severe extensive calcinosis associated with juvenile and adult dermatomyositis. (centerwatch.com)
- Treatment of calcinosis in juvenile dermatomyositis with probenecid: the role of phosphorus metabolism in the development of calcifications. (jrheum.org)
- OBJECTIVE: To report the efficacy of probenecid for calcinosis of juvenile dermatomyositis (JDM) and assess the changes in phosphorus metabolism during treatment. (jrheum.org)
- Calcinosis cutis is seen in 30% of adults and up to 70% of children and adolescents with dermatomyositis. (statpearls.com)
- People with connective tissue diseases such as systemic scleroderma , dermatomyositis and cutaneous lupus erythematosus may also develop calcinosis. (sclerodermanews.com)
- There is calcinosis cutis from prednisone a length significant prednisone therapy in akathisia grade that is modified by younger email at vanishedi and dermatomyositis strength. (auto-uitlaat.be)
- We report a 14-year-old girl with juvenile dermatomyositis (JDM) complicated by severe inflammatory calcinosis successfully treated with thalidomide. (biomedcentral.com)
- We report a 26-year-old woman with severe calcinosis associated with dermatomyositis. (elsevier.com)
- Although calcinosis of the skin or muscles is unusual in adults with dermatomyositis, this patient developed subcutaneous calcinosis with tenderness on the arms, axillary areas, shoulder areas, chest, abdomen, pelvis, and limbs. (elsevier.com)
Metastatic11
- Based upon the etiology of calcium deposition, there are five subtypes of calcinosis cutis: dystrophic, metastatic, idiopathic, iatrogenic, and calciphylaxis ( table 1 ). (uptodate.com)
- Metastatic calcinosis cutis results from abnormal calcium or phosphate metabolism, leading to the precipitation of calcium in skin and subcutaneous tissue. (uptodate.com)
- In dogs, the most common cause of metastatic calcinosis cutis is the overproduction of corticosteroids, a type of hormone produced by the adrenal glands. (vcahospitals.com)
- A less common cause of metastatic calcinosis cutis in dogs is corticosteroid ('steroid') treatment for extended periods of time (e.g., for allergies). (vcahospitals.com)
- Other, more rare, causes of metastatic calcinosis cutis include kidney disease (the most common cause in cats), diabetes mellitus, lung disease, and malignant tumors that produce abnormal hormones that increase blood calcium concentrations (including cancer of the anal glands and cancer of the lymphoid system). (vcahospitals.com)
- Calcinosis cutis is classified as dystrophic, metastatic, iatrogenic, or idiopathic based on these causative agents. (clinicaladvisor.com)
- Metastatic calcinosis cutis presents with altered calcium and phosphorus metabolism, typically in the setting of chronic renal disease. (clinicaladvisor.com)
- Metastatic calcinosis cutis may involve visceral calcifications as well as potentially generalized dermal or symmetrical periarticular distribution. (clinicaladvisor.com)
- Given the connection between metastatic calcinosis cutis and disorders of calcium and phosphorus metabolism, assessing serum calcium, phosphorus, and parathyroid hormone levels as well as a urine analysis, are crucial. (clinicaladvisor.com)
- More detailed information about the symptoms , causes , and treatments of Metastatic calcinosis cutis is available below. (rightdiagnosis.com)
- CT scan however demonstrates these calcifications in many more conditions like hamartoma (2) , chondroma (3) , carcinoid (4) , lung carcinoma (5) , metastatic calcifications following cardiac surgery in children (6) , calcinosis following liver transplant (7) , pulmonary alveolar microlithiasis (8) , Amiodarone pulmonary toxicity (9) to name a few. (ijars.net)
HFTC1
- Interestingly, a zebrafish animal model with reduced GALNT3 expression also showed HFTC-like phenotype, indicating an evolutionary conserved mechanism that is involved in developing tumoral calcinosis. (wikipedia.org)
Universalis4
- Tristano AG, Villarroel JL, Rodriguez MA, Millan A. Calcinosis cutis universalis in a patient with systemic lupus erythematosus. (medscape.com)
- Calcinosis universalis occurs when there is diffuse involvement of subcutaneous and fibrous structures of muscles and tendons. (statpearls.com)
- Calcinosis universalis in abdomen and pelvis. (reumatologiaclinica.org)
- Please cite this article as: Novella Navarro M, Muñoz Gómez MM, Salvatierra Ossorio J. Calcinosis universalis en paciente con dermatomiositis. (reumatologiaclinica.org)
Systemic16
- Miteva L, Pramatarov K, Vassileva S. Calcinosis cutis in childhood systemic lupus erythematosus. (medscape.com)
- Extensive calcinosis cutis with systemic lupus erythematosus. (medscape.com)
- Bullous systemic lupus erythematosus with milia and calcinosis. (medscape.com)
- The aim of the study is firstly to determine prevalence of calcinosis cutis, with hand and feet radiography realisation in a cohort of systemic sclerosis patient. (clinicaltrials.gov)
- Jeziorska, "Expression of advanced glycation end products and their receptor in skin from patients with systemic sclerosis with and without calcinosis ," Rheumatology, vol. (thefreedictionary.com)
- Calcinosis cutis is associated with systemic sclerosis. (statpearls.com)
- Calcinosis cutis commonly occurs in patients with systemic sclerosis, especially the limited form (CREST). (statpearls.com)
- Twenty-five percent to 40% of patients with limited systemic sclerosis will develop calcinosis cutis ten years after the onset of disease. (statpearls.com)
- An year-old woman was followed up for a year history of limited cutaneous systemic sclerosis complicated by recurrent subcutaneous lesions of calcinosis. (puppy-party.info)
- Calcinosis cutis often occurs along with systemic sclerosis scleroderma. (puppy-party.info)
- Al-Khudairi N et al: A case of symptomatic cervical spine calcinosis in systemic sclerosis. (statdx.com)
- Sambataro D et al: Tumoral calcinosis of the spine in the course of systemic sclerosis: report of a new case and review of the literature. (statdx.com)
- Identify the features of calcinosis cutis and of associated systemic diseases. (statpearls.com)
- Association of TNFSF4 (OX40L) polymorphisms with systemic sclerosis-related calcinosis. (cdc.gov)
- A Case of Primary Hyperparathyroidism Associated with Hypercalcemic Crisis and Systemic Calcinosis. (e-enm.org)
- Nephrocarcinosis and cutaneous cacifications have been recognized in patients with chronic renal failure, but the hypercalcemic crisis and systemic calcinosis are extremely rare in patients with primary hyperparathyroidism. (e-enm.org)
Scrotal14
- M. Dini and M. Colafranceschi, "Should scrotal calcinosis still be termed idiopathic? (hindawi.com)
- A. G. Saad and G. S. Zaatari, "Scrotal calcinosis: is it idiopathic? (hindawi.com)
- J. M. Swinehart and L. E. Golitz, "Scrotal calcinosis. (hindawi.com)
- U. H. G. Michl, A. J. Gross, V. Loy, and K. P. Dieckmann, "Idiopathic calcinosis of the scrotum-a specific entity of the scrotal skin. (hindawi.com)
- Scrotal calcinosis has traditionally been classified as a type of idiopathic calcinosis cutis that presents as multiple, firm nodules on the scrotum. (clinicaladvisor.com)
- This association raises the question as to whether scrotal calcinosis would be more appropriately classified as a type of dystrophic calcinosis cutis. (clinicaladvisor.com)
- Idiopathic scrotal calcinosis is a rare benign disease which presents with multiple asymptomatic various sized nodules on the scrotal skin wall. (alliedacademies.org)
- It includes tumoral calcinosis, subepidermal calcified nodules, and scrotal calcinosis. (statpearls.com)
- Idiopathic calcinosis cutis of the scrotum (ICCS), also called idiopathic scrotal calcinosis, is an uncommon entity and was first described by Lewinski in 1883 [ 2 ]. (biomedcentral.com)
- In recent times, there has been a debate on the pathogenesis of scrotal calcinosis, with questions being raised on its idiopathic nature [ 3 , 4 ]. (biomedcentral.com)
- Idiopathic Scrotal Calcinosis is a skin condition that I occasionally encounter in both my The Woodlands dermatology and Conroe dermatology offices. (perridermatology.com)
- Idiopathic calcinosis cutis of the scrotum is one diagnosis of a scrotal mass. (kjuo.or.kr)
- 2 established idiopathic scrotal calcinosis as a distinct entity in 1970, several cases had been reported worldwide. (kjuo.or.kr)
- Thus, we present a case of a 35-year-old male patient with massive idiopathic scrotal calcinosis. (kjuo.or.kr)
Cutaneous8
- Deposition of insoluble calcium salts in the tissue, cutaneous calcinosis (CC), can be caused by various diseases. (thefreedictionary.com)
- Among the cutaneous features (Table 1), fingertip ulceration was found in 36 (66.7%), sclerodactyly in 48 (88.8%) (Figure 1), digital pitted scars in 30 (55.5%) (Figure 2), digital gangrene in 3 (5.6%), calcinosis cutis in 4 (7.4%), microstomia in 48 (88.8%) (Figure 3), radial furrows around mouth in 18 (33.3%) (Figure 4), pinched nose in 33 (61.1%), diffuse alopecia in 10 (18.5%) and nail changes in 10 (18.5%) cases. (thefreedictionary.com)
- Calcinosis cutis is a descriptive term for the deposition of insoluble calcium salts in the cutaneous and subcutaneous tissue. (uptodate.com)
- A calcinosis characterized by autosomal recessive inheritance of elevated blood calcium levels and calcium phosphate crystals in cutaneous and subcutaneous tissues that has_material_basis_in mutation in the GALNT3 gene, the FGF23 gene, or the KL gene. (jax.org)
- We describe a case of PSC occurring in a patient with CREST (calcinosis cutis, Raynaud phenomenon, esophageal dysmotility, sclerodactyly and telangiectasia) syndrome, which is a type of limited cutaneous scleroderma. (biomedcentral.com)
- As cutaneous manifestations, aside from lesions compatible with Gottron's papules on upper extremities, the patient presented with "calcinosis cutis" consisting of scattered nodules and plaques, some ulcerated and suppurating in both gluteal regions and on right elbow. (reumatologiaclinica.org)
- Disorders of calcium-phosphate-parathormone balance, are very important issues in ESRD patients, that may lead to severe complications, as dystrophic calcinosis cutis, a rare disease, caused by calcium salt deposits in cutaneous or subcutaneous tissues and many organs. (giornaleitalianodinefrologia.it)
- Histological exam revealed deposition of amorphic material with calcific component, consistent with cutaneous dystrophic calcinosis. (giornaleitalianodinefrologia.it)
Lesions5
- Pets with calcinosis cutis typically have lesions (papules or plaques) with a gritty rough surface which may be quite itchy. (vcahospitals.com)
- Others had significant improvement in calcinosis with no new lesions, decreased sites and density and decreased calcinosis related contractures. (scirp.org)
- The outlook for calcinosis cutis depends on its underlying disease or cause, and the severity of your lesions. (puppy-party.info)
- Generalized calcinosis rapidly progressed with high fever, multiple skin/subcutaneous inflammatory lesions, and increased level of CRP. (biomedcentral.com)
- Because calcinosis cutis are not always well defined, a recurrence of the lesions may occur. (biomedcentral.com)
Termed calcinosis cutis1
- Abnormal deposition of calcium in the skin or subcutaneous tissue is termed calcinosis cutis. (biomedcentral.com)
Deposition9
- Tumoral calcinosis is a rare condition in which there is calcium deposition in the soft tissue in periarticular location, around joints, outside the joint capsule. (wikipedia.org)
- The name indicates calcinosis (calcium deposition) which resembles tumor (like a new growth). (wikipedia.org)
- Iatrogenic calcinosis cutis is the deposition of calcium salts in the skin as a side effect of medical intervention for other disease processes. (uptodate.com)
- The deposition of calcium in the skin, subcutaneous tissue, muscles and visceral organs is known as calcinosis. (dermnetnz.org)
- Subdermal nodules and papules of calcium deposition on the posterior upper thigh of a patient with calcinosis cutis. (clinicaladvisor.com)
- 12 A calcinosis that is characterized by massive periarticular, and seldom visceral, deposition of calcified tumors. (malacards.org)
- Iatrogenic calcinosis cutis arises secondary to a treatment or procedure, for example parenteral administration of calcium or phosphate, and calcium deposition in newborns from repeated heel sticks. (puppy-party.info)
- Calcinosis cutis is an uncommon disorder characterized deposition of crystals of calsium phosphate (hydroxyapatite) in the skin in various areas of the body. (biomedcentral.com)
- Calcinosis cutis is an uncommon disorder which results in progressive deposition of insoluble calsium salts (crystals of calcium phosphate, hydroxyapatite) in the skin. (biomedcentral.com)
Known as calcinosis1
- People with DM and JDM can develop calcium deposits in places they should not, known as calcinosis. (clinicaltrials.gov)
Treatment of Calcinosis2
- Medical therapy has very limited role in the treatment of calcinosis cutis but drugs like corticosteroids, probenecid, colchicine, sodium etidronate, diphosphonates, diltiazem, and magnesium and aluminium antacids can be used in order to relieve the symptoms9,10. (thefreedictionary.com)
- Conclusion: Our study showed the favorable effect of rituximab in treatment of calcinosis in 4 patients with JDM-associated severe calcinosis when it was used with other conventional DMARDs. (scirp.org)
Severe9
- People ages 7 and older who have moderate or severe calcinosis. (clinicaltrials.gov)
- Eligible patients will be age 7 or older, and will have extensive calcinosis (defined as calcinosis involving the torso or 2 extremities) and moderate to severe calcinosis (indicated by a calcinosis activity visual analogue scale score of greater than or equal to 3.5 cm out of 10 cm). (centerwatch.com)
- Although iatrogenic calcinosis cutis is generally a benign entity, the early recognition of the presentation of extravasation of calcium gluconate is important to avoid severe complications and possible medical malpractice disputes. (biomedsearch.com)
- We report the favorable outcome of rituximab on severe calcinosis in 4 JDM patients and present their clinical data. (scirp.org)
- Patients and Methods: A retrospective chart review of 4 children with JDM and severe calcinosis who received rituximab for relapsing or polycyclic JDM course. (scirp.org)
- Calcinosis was severe causing ulceration, recurrent skin infections and joint limitation. (scirp.org)
- Frequent high fever and local severe pain with calcinosis were suppressed. (biomedcentral.com)
- We report a case of severe calcinosis in a 14-year-old girl who was treated with thalidomide, a treatment encouraged by the partial effectiveness of etanercept, a soluble TNF receptor fusion protein. (biomedcentral.com)
- Severe pulmonary calcinosis has not previously been reported in children with PHPT. (cu.edu.tr)
Diagnosis5
- Diagnosis and follow up of calcinosis was clinically and by X-ray. (scirp.org)
- A final diagnosis of calcinosis cutis was made based on histopathological and clinical findings. (oalib.com)
- Based on clinical features and laboratory reports, a diagnosis of idiopathic calcinosis cutis of the scrotum was made. (biomedcentral.com)
- Gastric mucosal calcinosis is a very rare pathologic diagnosis and we aimed to present this case with reference to the literature data. (heighpubs.org)
- Calcinosis had been recognized 18 months after the diagnosis was made (Fig. 1 ). (biomedcentral.com)
Benign1
- Idiopathic calcinosis cutis of the scrotum is a benign condition, which remains mostly asymptomatic. (biomedcentral.com)
Clinical8
- In addition to the classical clinical and biochemical features of hyperphosphatemic tumoral calcinosis, the patient exhibited markedly elevated intact and C-terminal FGF23 levels, suggestive of FGF23 resistance. (jci.org)
- The authors present the clinical case of a dog with seropositive leishmaniosis and secondary immune-mediated haemolytic anaemia who was affected by intense dermatopathia on the dorsal area, diagnosed by a biopsy as calcinosis cutis. (bva.co.uk)
- Pathology department's opinion was that the mucosal calcinosis observed in the corpus mucosa could be associated with calcium dysregulation and could also be secondary to medication, and recommended analyzing correlation with clinical findings. (heighpubs.org)
- CREST ( calcinosis , Raynaud phenomenon , esophageal dysmotility , sclerodactyly, and telangiectasia) syndrome is a member of the heterogeneous group of sclerodermas , and its name is an acronym for the cardinal clinical features of the syndrome. (medscape.com)
- McGuinness FE: Hyperphosphataemic tumoral calcinosis in Bedouin Arabs--clinical and radiological features. (statdx.com)
- Noyez JF et al: Tumoral calcinosis, a clinical report of eleven cases. (statdx.com)
- Clinical experience suggests the utility of sodium thiosulfate to treat delayed calcium extravasation in patients with severely debilitating, unresolving, or limb-threatening calcinosis cutis [Reynolds 2014] . (drugs.com)
- Clinical presentation and radiographs of patient with tumoral calcinosis. (jci.org)
Occurs6
- Calcinosis usually occurs in and just under skin tissue around the joints, most often the hips, shoulders, and elbows. (medlineplus.gov)
- Rarely, calcinosis occurs in blood vessels or in the brain and can cause serious health problems. (medlineplus.gov)
- Calcinosis cutis occurs in susceptible pets in areas where local skin damage has occurred. (vcahospitals.com)
- Dystrophic calcinosis cutis typically occurs as a result of physical injury to tissues or reactions to injections and other foreign materials that tissues may be exposed to. (vcahospitals.com)
- Calcinosis cutis occurs when calcium salts are deposited into the skin and subcutaneous tissue. (statpearls.com)
- The onset of calcinosis usually occurs one to three years after that of the illness. (biomedcentral.com)
Calcifications4
- Radiography of her hands revealed the resorption of the distal phalangeal tufts (acro-osteolysis) and soft tissue calcifications ( calcinosis cutis) (Figure 2). (thefreedictionary.com)
- Tumoral calcinosis presents as large, painless periarticular calcifications, most commonly in the hips and shoulders. (clinicaladvisor.com)
- B ) Radiograph of the lesion revealed a soft tissue mass with amorphous calcifications around the right greater trochanter consistent with tumoral calcinosis. (jci.org)
- Reciprocally tumoral calcinosis (TC) patients are often hyperphosphatemic with inappropriately normal or elevated serum 1,25(OH) 2 D 3 levels and have eciopic and vascular calcifications, a phenotype similar to that of Fgf23 null mice. (elsevier.com)
Pathogenesis3
- The pathogenesis of idiopathic calcinosis cutis of the scrotum is debatable. (biomedcentral.com)
- Here we report a case of idiopathic calcinosis cutis of the scrotum with a brief review of the literature and a discussion on pathogenesis. (biomedcentral.com)
- Our understanding of the pathogenesis of calcinosis is still very limited. (biomedcentral.com)
Etiology1
- Lesion distribution in calcinosis cutis is closely connected to its etiology. (clinicaladvisor.com)
Deposits13
- Calcinosis is the formation of calcium deposits in any soft tissue. (wikipedia.org)
- Calcinosis typically develops in early childhood to early adulthood, although in some people the deposits first appear in infancy or in late adulthood. (medlineplus.gov)
- Calcinosis results when the excess phosphate combines with calcium to form deposits that build up in soft tissues. (medlineplus.gov)
- These include growth retardation and rickets (a disease affecting bone development) in children, and a series of metabolic disorders such as low potassium levels (hypokalemia), high calcium levels (hypercalcemia), elevated calcium in the urine (hypercalciuria) resulting in kidney stones, the formation of calcium deposits in the kidneys ( calcinosis ) as well as possible kidney failure. (thefreedictionary.com)
- Bilateral striopallidodentate calcinosis (BSPDC, also erroneously called Fahr disease) is characterized by the accumulation of calcium deposits in different brain regions, particularly the basal ganglia and dentate nucleus, and is often associated with neurodegeneration. (orpha.net)
- On physical examination, calcinosis cutis' dermal calcium deposits present as numerous, firm dermal or subcutaneous papules, nodules, or plaques with either a white or yellow coloring (Figure 1, Figure 2). (clinicaladvisor.com)
- Calcinosis or calcinosis cutis is the accumulation of calcium deposits in or under the skin. (sclerodermanews.com)
- If calcinosis deposits do not cause discomfort or impede function, they may not require treatment and can be left alone if the patient so desires. (sclerodermanews.com)
- Calcinosis deposits occasionally resolve themselves spontaneously . (sclerodermanews.com)
- If calcinosis deposits become very painful, cause recurrent secondary infections or impair function, a doctor may recommend surgical removal . (sclerodermanews.com)
- On histology of calcinosis cutisgranules and deposits of calcium are seen in the dermisoften with a surrounding foreign-body giant cell reaction. (puppy-party.info)
- Calcinosis is a condition that manifests as calcium deposits in the skin and other tissues of the body. (medindia.net)
- Over the 18 months of observation up to the present, she has had no inflammatory calcinosis, or needed any hospitalization, although established calcium deposits still remain. (biomedcentral.com)
Hyperphosphatemia1
- We have recently seen a patient with tumoral calcinosis, a syndrome comprising hyperphosphatemia, normocalcemia, normal glomerular filtration rate (GFR), and extensive periarticular calcific masses. (annals.org)
FGF231
- Thus, this report describes the first case, to our knowledge, of autoimmune hyperphosphatemic tumoral calcinosis with pathogenic autoantibodies targeting FGF23. (jci.org)
Scleroderma3
- 2 Subcutaneous calcinosis, as part of the CREST variant or diffuse variant, is often seen on the extensor surfaces and in areas that tend to have a lot of friction and is seen in approximately 58% of scleroderma patients. (appliedradiology.com)
- 7 The combination of calcinosis and acro-osteolysis, as seen in Figure 2, is considered to be pathognomic for scleroderma. (appliedradiology.com)
- Dystrophic calcinosis in a patient with overlap syndrome (scleroderma and rheumatoid arthritis) treated by leflunomide: A case report. (annals.org)
Uncommon2
- Uncommon localization of calcinosis cutis after liver transplantation. (medscape.com)
- Idiopathic calcinosis cutis of the scrotum is an uncommon entity. (biomedcentral.com)
Nodules3
- Subepidermal calcified nodules or Winder nodular calcinosis presents in children and can present at birth. (statpearls.com)
- Liquefaction of calcinosis nodules with improvement of mobility occurred gradually. (macquariestemcells.com)
- She is now 24 months post-transplant with no sign of disease activity and total disappearance of calcinosis nodules. (macquariestemcells.com)
Develop calcinosis cutis1
- An estimated 25 to 40 percent of those with CREST syndrome will develop calcinosis cutis after 10 years. (puppy-party.info)
Iatrogenic calcinosis cutis1
- We present a rare case of iatrogenic calcinosis cutis complicated by compartment syndrome secondary to extravasation of iv calcium gluconate in a neonate. (biomedsearch.com)
Dystrophic cardiac calcinosis1
- The genetic loci determining dystrophic cardiac calcinosis in an F2 intercross of resistant C57BL/6J and susceptible C3H/HeJ inbred strains were identified. (eurekamag.com)
Tumoral calcinosis associated1
- McGregor DH et al: Nonfamilial tumoral calcinosis associated with chronic renal failure and secondary hyperparathyroidism: report of two cases with clinicopathological, immunohistochemical, and electron microscopic findings. (statdx.com)
Mawdsley Calcinosis Questionnaire1
- Mawdsley Calcinosis Questionnaire is an 18-question survey, each question ranges from 0-10. (clinicaltrials.gov)
Abstract1
- ABSTRACT: Background: Calcinosis is an important sequela of JDM which may cause significant morbidity and mortality. (scirp.org)
Patients8
- Patients met 2013 ACR/ EULAR criteria, 1980 ACR criteria, or at least three of five features of CREST ( calcinosis , Raynaud's phenomenon, esophageal dysmotility, sclerodactyly, telangiectasia) syndrome. (thefreedictionary.com)
- To assess baseline cortical area and cortical porosity measured by HR-pQCT in SSc patients with calcinosis. (clinicaltrials.gov)
- Recently published reports as well as personal observations within our group have suggested that intravenous sodium thiosulfate treatment may benefit calcinosis patients. (centerwatch.com)
- All patients had improvement in disease activity and frequency of admission especially due to complications of calcinosis. (scirp.org)
- In 1910, Thibierge and Weissenbach described the first case report of what was later called CRST (calcinosis cutis, Raynaud phenomenon, sclerodactyly, and telangiectasia) syndrome in English by Winterbauer who, in 1964, described a series of 8 patients with the features that make up the abbreviation CRST. (medscape.com)
- This activity reviews the evaluation and management of calcinosis cutis and highlights the role of the interprofessional team in improving care for affected patients. (statpearls.com)
- Explain the importance of improving coordination amongst the interprofessional team to enhance care and outcomes for patients affected by calcinosis cutis. (statpearls.com)
- Pharmacist pharmacist was reduced and equivalent however stopped in calcinosis commonly four patients after prednisone. (auto-uitlaat.be)
Calcium or phosphate1
- Excessive vitamin D intake may also cause calcinosis and so can taking calcium or phosphate. (sclerodermanews.com)
Evaluation of Calcinosis1
- Review the laboratory studies that should be obtained in the evaluation of calcinosis cutis. (statpearls.com)
Soft tissue1
- Calcinosis may also develop in the soft tissue of the feet, legs, and hands. (medlineplus.gov)
Renal2
- This was considered to be consistent with Tumoral Calcinosis in the setting of long-standing renal disease. (thefreedictionary.com)
- Tumoral calcinosis with renal calculus. (bvsalud.org)
Sodium thiosulfate1
- To test if sodium thiosulfate (STS) can treat people with DM with calcinosis. (clinicaltrials.gov)
Diffuse2
- We do not directly treat Diffuse Calcinosis. (macquariestemcells.com)
- TITLE: "Disappearance of diffuse calcinosis following autologous stem cell transplantation in a child with autoimmune disease" (Elhasid R., et al. (macquariestemcells.com)
Commonly1
- Calcinosis cutis is commonly described, but its prevalence and appear few documented in literature. (clinicaltrials.gov)
Subcutaneous calcinosis1
- Subcutaneous calcinosis, a disease tending to serious bodily disability, presents a most difficult therapeutic problem. (annals.org)
Diseases3
- BACKGROUND: Dystrophic calcinosis cutis is a common manifestation in connective tissue diseases, but there's still no consensus on treatment. (puppy-party.info)
- Pharmacological treatment in calcinosis cutis associated with connective-tissue diseases. (puppy-party.info)
- CREST (calcinosis, Raynaud phenomenon, oesophageal dysmotility, sclerodactyly, and telangiectasia) syndrome comprising calcinosis cutis, Raynaud phenomenon, esophageal dysmotility, sclerodactyly and telangiectasia and primary sclerosing cholangitis are both chronic fibrotic diseases but the association between them is extremely rare. (biomedcentral.com)