Calcinosis: Pathologic deposition of calcium salts in tissues.CREST Syndrome: A mild form of LIMITED SCLERODERMA, a multi-system disorder. Its features include symptoms of CALCINOSIS; RAYNAUD DISEASE; ESOPHAGEAL MOTILITY DISORDERS; sclerodactyly, and TELANGIECTASIS. When the defect in esophageal function is not prominent, it is known as CRST syndrome.Skin Diseases, Metabolic: Diseases of the skin associated with underlying metabolic disorders.Dermatomyositis: A subacute or chronic inflammatory disease of muscle and skin, marked by proximal muscle weakness and a characteristic skin rash. The illness occurs with approximately equal frequency in children and adults. The skin lesions usually take the form of a purplish rash (or less often an exfoliative dermatitis) involving the nose, cheeks, forehead, upper trunk, and arms. The disease is associated with a complement mediated intramuscular microangiopathy, leading to loss of capillaries, muscle ischemia, muscle-fiber necrosis, and perifascicular atrophy. The childhood form of this disease tends to evolve into a systemic vasculitis. Dermatomyositis may occur in association with malignant neoplasms. (From Adams et al., Principles of Neurology, 6th ed, pp1405-6)Hyperphosphatemia: A condition of abnormally high level of PHOSPHATES in the blood, usually significantly above the normal range of 0.84-1.58 mmol per liter of serum.N-Acetylgalactosaminyltransferases: Enzymes that catalyze the transfer of N-acetylgalactosamine from a nucleoside diphosphate N-acetylgalactosamine to an acceptor molecule which is frequently another carbohydrate. EC 2.4.1.-.Skin DiseasesScleroderma, Systemic: A chronic multi-system disorder of CONNECTIVE TISSUE. It is characterized by SCLEROSIS in the SKIN, the LUNGS, the HEART, the GASTROINTESTINAL TRACT, the KIDNEYS, and the MUSCULOSKELETAL SYSTEM. Other important features include diseased small BLOOD VESSELS and AUTOANTIBODIES. The disorder is named for its most prominent feature (hard skin), and classified into subsets by the extent of skin thickening: LIMITED SCLERODERMA and DIFFUSE SCLERODERMA.Calciphylaxis: Condition of induced systemic hypersensitivity in which tissues respond to appropriate challenging agents with a sudden local calcification.Foot Diseases: Anatomical and functional disorders affecting the foot.Joint DiseasesTelangiectasis: Permanent dilation of preexisting blood vessels (CAPILLARIES; ARTERIOLES; VENULES) creating small focal red lesions, most commonly in the skin or mucous membranes. It is characterized by the prominence of skin blood vessels, such as vascular spiders.Hyperostosis, Cortical, Congenital: A disease of young infants characterized by soft tissue swellings over the affected bones, fever, and irritability, and marked by periods of remission and exacerbation. (Dorland, 27th ed)Skin UlcerCalcium Gluconate: The calcium salt of gluconic acid. The compound has a variety of uses, including its use as a calcium replenisher in hypocalcemic states.Nadroparin: A heparin fraction with a mean molecular weight of 4500 daltons. It is isolated from porcine mucosal heparin and used as an antithrombotic agent. (From Merck Index, 11th ed)Eyelid DiseasesCalcium Pyrophosphate: An inorganic pyrophosphate which affects calcium metabolism in mammals. Abnormalities in its metabolism occur in some human diseases, notably HYPOPHOSPHATASIA and pseudogout (CHONDROCALCINOSIS).Nephrocalcinosis: A condition characterized by calcification of the renal tissue itself. It is usually seen in distal RENAL TUBULAR ACIDOSIS with calcium deposition in the DISTAL KIDNEY TUBULES and the surrounding interstitium. Nephrocalcinosis causes RENAL INSUFFICIENCY.Durapatite: The mineral component of bones and teeth; it has been used therapeutically as a prosthetic aid and in the prevention and treatment of osteoporosis.alpha-2-HS-Glycoprotein: A fetuin subtype that is synthesized by HEPATOCYTES and secreted into the circulation. It plays a major role in preventing CALCIUM precipitation in the BLOOD.Basal Ganglia Diseases: Diseases of the BASAL GANGLIA including the PUTAMEN; GLOBUS PALLIDUS; claustrum; AMYGDALA; and CAUDATE NUCLEUS. DYSKINESIAS (most notably involuntary movements and alterations of the rate of movement) represent the primary clinical manifestations of these disorders. Common etiologies include CEREBROVASCULAR DISORDERS; NEURODEGENERATIVE DISEASES; and CRANIOCEREBRAL TRAUMA.Phosphates: Inorganic salts of phosphoric acid.Dermatologic Agents: Drugs used to treat or prevent skin disorders or for the routine care of skin.Raynaud Disease: An idiopathic vascular disorder characterized by bilateral Raynaud phenomenon, the abrupt onset of digital paleness or CYANOSIS in response to cold exposure or stress.Fibroblast Growth Factors: A family of small polypeptide growth factors that share several common features including a strong affinity for HEPARIN, and a central barrel-shaped core region of 140 amino acids that is highly homologous between family members. Although originally studied as proteins that stimulate the growth of fibroblasts this distinction is no longer a requirement for membership in the fibroblast growth factor family.Cardiomyopathies: A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classified according to their predominant pathophysiological features (DILATED CARDIOMYOPATHY; HYPERTROPHIC CARDIOMYOPATHY; RESTRICTIVE CARDIOMYOPATHY) or their etiological/pathological factors (CARDIOMYOPATHY, ALCOHOLIC; ENDOCARDIAL FIBROELASTOSIS).Antibodies, Antinuclear: Autoantibodies directed against various nuclear antigens including DNA, RNA, histones, acidic nuclear proteins, or complexes of these molecular elements. Antinuclear antibodies are found in systemic autoimmune diseases including systemic lupus erythematosus, Sjogren's syndrome, scleroderma, polymyositis, and mixed connective tissue disease.GlucuronidasePhosphorus: A non-metal element that has the atomic symbol P, atomic number 15, and atomic weight 31. It is an essential element that takes part in a broad variety of biochemical reactions.Centromere: The clear constricted portion of the chromosome at which the chromatids are joined and by which the chromosome is attached to the spindle during cell division.Osteopontin: A negatively-charged extracellular matrix protein that plays a role in the regulation of BONE metabolism and a variety of other biological functions. Cell signaling by osteopontin may occur through a cell adhesion sequence that recognizes INTEGRIN ALPHA-V BETA-3.Fingers: Four or five slender jointed digits in humans and primates, attached to each HAND.Autoantibodies: Antibodies that react with self-antigens (AUTOANTIGENS) of the organism that produced them.Skin: The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.Biopsy: Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.Calcium: A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.Kidney Failure, Chronic: The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION.Cutis Laxa: A group of connective tissue diseases in which skin hangs in loose pendulous folds. It is believed to be associated with decreased elastic tissue formation as well as an abnormality in elastin formation. Cutis laxa is usually a genetic disease, but acquired cases have been reported. (From Dorland, 27th ed)Glycodeoxycholic Acid: A bile salt formed in the liver by conjugation of deoxycholate with glycine, usually as the sodium salt. It acts as a detergent to solubilize fats for absorption and is itself absorbed. It is used as a cholagogue and choleretic.Terminology as Topic: The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.Lung Compliance: The capability of the LUNGS to distend under pressure as measured by pulmonary volume change per unit pressure change. While not a complete description of the pressure-volume properties of the lung, it is nevertheless useful in practice as a measure of the comparative stiffness of the lung. (From Best & Taylor's Physiological Basis of Medical Practice, 12th ed, p562)Scleroderma, Localized: A term used to describe a variety of localized asymmetrical SKIN thickening that is similar to those of SYSTEMIC SCLERODERMA but without the disease features in the multiple internal organs and BLOOD VESSELS. Lesions may be characterized as patches or plaques (morphea), bands (linear), or nodules.Respiratory Function Tests: Measurement of the various processes involved in the act of respiration: inspiration, expiration, oxygen and carbon dioxide exchange, lung volume and compliance, etc.Vital Capacity: The volume of air that is exhaled by a maximal expiration following a maximal inspiration.Hyperostosis: Increase in the mass of bone per unit volume.Luciferases, Renilla: Luciferases from RENILLA that oxidizes certain LUMINESCENT AGENTS to cause emission of PHOTONS.Immunoprecipitation: The aggregation of soluble ANTIGENS with ANTIBODIES, alone or with antibody binding factors such as ANTI-ANTIBODIES or STAPHYLOCOCCAL PROTEIN A, into complexes large enough to fall out of solution.Photography: Method of making images on a sensitized surface by exposure to light or other radiant energy.Copyright: It is a form of protection provided by law. In the United States this protection is granted to authors of original works of authorship, including literary, dramatic, musical, artistic, and certain other intellectual works. This protection is available to both published and unpublished works. (from Circular of the United States Copyright Office, 6/30/2008)Software: Sequential operating programs and data which instruct the functioning of a digital computer.

Broncholithiasis: rare but still present. (1/3283)

Broncholithiasis is a rare but distinct and potentially dangerous pulmonary problem that still needs to be considered in the differential diagnosis of some patients with bronchial obstruction. Broncholiths originate from calcified material in peribronchial lymph nodes eroding into the tracheobronchial tree. The clinical and chest X-ray signs are usually non-specific, but the diagnosis can nowadays be made based on clinical suspicion, CT-scan and fibre-optic bronchoscopy findings, so that a malignant cause of airway obstruction can be ruled out. The removal of broncholiths during fibre-optic bronchoscopy is seldom possible and rather dangerous. They can be removed safely by rigid bronchoscopy with the aid of Nd-YAG laser photocoagulation. Thoracotomy is indicated in complicated cases with fistula formation or severe bleeding.  (+info)

Role of glutaraldehyde in calcification of porcine aortic valve fibroblasts. (2/3283)

Glutaraldehyde-treated porcine aortic valve xenografts frequently fail due to calcification. Calcification in the prostheses begins intracellularly. In a previous study, various types of cell injury to canine valvular fibroblasts, including glutaraldehyde treatment, led to calcification. An influx of extracellular Ca2+ into the phosphate-rich cytosol was theorized to be the mechanism of calcification. To test the Ca2+ influx theory, cytosolic Ca2+ and Pi concentrations were assessed in glutaraldehyde-treated porcine aortic valve fibroblasts, and their relationship to a subsequent calcification was studied. Glutaraldehyde caused an immediate and sustained massive cytosolic Ca2+ increase that was dose dependent and a several-fold increase in Pi. Calcification of cells followed within a week. The earliest calcification was observed in blebs formed on glutaraldehyde-treated cells. Live control cells or cells fixed with glutaraldehyde in Ca2+-free solution did not calcify under the same conditions. Concomitant increases in Ca2+ and Pi in glutaraldehyde-treated cells appear to underlie the mechanism of calcification, and the presence of extracellular Ca2+ during glutaraldehyde fixation promotes calcification.  (+info)

Histology and tissue chemistry of tidemark separation in hamsters. (3/3283)

Adult articular cartilage is divided by the tidemark into a deep calcified layer and a more superficial uncalcified layer. Histologic examination of articular cartilage from the knee joint of golden Syrian hamsters 123 days of age or older revealed defects at the tidemark in the tibia. Defects ranged from small separations of the calcified and uncalcified layers along the tidemark to progressively larger defects apparently formed by dissolution. These larger defects appeared as cavities in the noncalcified cartilage, had smooth rather than rough edges, frequently contained coalesced debris, and often resulted in a bulge in the articular surface. Occasionally, these large defects broke through the articular surface. Defects were not observed in tibial cartilage of younger (<90 days old) hamsters or in femoral cartilage from hamsters of any age. Exercise neither protected against nor increased the severity of the defects. Collagen cross-linking by pyridinoline was examined as a function of age and increased from 1,090 to 3,062 micromoles of pyridinoline/mole of hydroxyproline over the period of 1-9 months of age but was not correlated with defect formation. With increasing age, these focal tidemark defects could lead to osteoarthrosis-like cartilage lesions.  (+info)

Incidence and clinical relevance of coronary calcification detected by electron beam computed tomography in heart transplant recipients. (4/3283)

BACKGROUND: Patients treated by cardiac transplantation who survive beyond one year are at significant risk from fatal coronary artery disease. The development of coronary artery calcification in these patients is discussed and methods available to detect it are reviewed. OBJECTIVES: To assess the clinical importance of coronary artery calcium in heart transplant recipients. METHODS: In a cohort of 102 cardiac transplant recipients, electron beam computed tomography was used to measure calcium in the coronary arterial wall 63 days to 9.1 years (median 4.6 years) after transplantation. The results were compared with angiographic findings and with conventional coronary disease risk factors. The patients were followed for a mean of 2.12 years (1.2-4.02 years) to assess the relationship between these findings and future cardiac events. RESULTS: Forty-one (40.2%) had a stenosis of > 24% in one or more major coronary artery at angiography. Forty-six (45%) had a coronary calcium score > 0. The absence of calcium had a negative predictive value with respect to angiographic disease in any vessels of 87.5%. Logistic regression revealed that dyslipidaemia, systemic hypertension and organ ischaemic time were significant predictors of calcification. At follow-up, both an abnormal coronary angiogram and coronary calcium were found to be the only significant predictors of late events. Multivariate analysis suggested that the detection of coronary calcium did not offer any additional predictive information over that provided by the angiogram itself. CONCLUSION: Electron beam computed tomography is well suited to the assessment of calcium in the coronary arteries of heart transplant recipients, although the mechanisms of this calcification remain poorly understood. Calcium is detected more frequently than would be suggested by studies using intravascular ultrasound. It is associated with the presence of angiographic disease, and with some conventional risk factors for coronary disease. At follow-up the presence of coronary calcium was associated with an adverse clinical outcome, as it is in conventional ischaemic heart disease.  (+info)

Renal biopsy in the milk-alkali syndrome. (5/3283)

In milk-alkali syndrome the degree of renal impairment varies greatly. Few reports have been published describing structural changes on renal biopsy. In three illustrative cases, impairment of renal function was related to morphological changes shown on percutaneous biopsy. Milk-alkali syndrome should be considered as a cause of renal dysfunction in patients with a long history of dyspensia.  (+info)

Degenerative changes in aortic root allografts placed in the right ventricular outflow tract of growing puppies. (6/3283)

Differently prepared aortic root allografts were implanted in the right ventricular outflow tract of growing puppies to determine the site of origin and progress of degenerative changes in these conduits. The three preparations assessed were as follows: group A, fresh and sterile grafts; group B, antibiotic sterilized grafts in nutrient medium; and group C, beta-propiolactone sterilized grafts. Although calcification of the aortic wall occurred in all groups, the aortic leaflets were minimally affected. A correlation between viability and lack of calcification and between viability and long-term function is emphasized.  (+info)

Calcific myonecrosis. (7/3283)

Calcific myonecrosis is a rare and late sequela of compartment syndrome, which becomes symptomatic years after the initial trauma. We diagnosed this condition in a 64-year old man, 42 years after he sustained a shot-gun wound to the right lower leg. Total excision of a peripherally calcified, cystic mass, continuous with the anterior tibial muscle belly resulted in complete resolution of symptoms. Consideration of the diagnosis is warranted in patients with a history of major injury who develop a soft tissue mass in the traumatized compartment. The treatment of choice is marginal excision.  (+info)

Angiographic correlation of CT calcification in the carotid siphon. (8/3283)

BACKGROUND AND PURPOSE: Calcification in the coronary arteries has been correlated with significant vessel stenosis. The predictive value of calcification within the carotid siphon has not been characterized; however, stenosis in the carotid siphon is potentially important in determining management of patients with ipsilateral carotid bifurcation stenosis. The purpose of this study was to determine optimal parameters for assessing carotid siphon calcification on head CT scans and to compare the CT findings with angiographic results. METHODS: We performed a retrospective review of patients referred for diagnostic carotid arteriography. Those patients who also had undergone a head CT study at our institution were selected. The CT scans and angiograms of 64 patients (128 vessels) were reviewed. Carotid siphon calcification on CT scans was characterized on brain and bone windows as mild, moderate, or severe. Comparison was then made with angiographic findings. RESULTS: The sensitivity and specificity of CT for depicting greater than 50% angiographic stenosis in the carotid siphon were 86% and 98%, respectively, for bone windows and 100% and 0%, respectively, for brain windows. The positive predictive value (PPV) for a stenosis of greater than 50% as evidenced by severe calcification was 86% on bone windows and 11% on brain windows. The PPV for mild and moderate calcification on bone windows was 2.5% and 0%, respectively. CONCLUSION: Severe CT calcification in the carotid siphon as characterized on bone windows correlates with a carotid siphon stenosis of greater than 50% as determined angiographically. Therefore, the identification of severe calcification offers a potential noninvasive method for identifying stenosis of the carotid siphon. This information may be essential in determining management and prognosis for patients with carotid bifurcation stenosis.  (+info)

Dystrophic calcification (DC) is the calcification occurring in degenerated or necrotic tissue, as in hyalinized scars, degenerated foci in leiomyomas, and caseous nodules. This occurs as a reaction to tissue damage, including as a consequence of medical device implantation. Dystrophic calcification can occur even if the amount of calcium in the blood is not elevated. (A systemic mineral imbalance would elevate calcium levels in the blood and all tissues and cause metastatic calcification.) Basophilic calcium salt deposits aggregate, first in the mitochondria, and progressively throughout the cell. These calcifications are an indication of previous microscopic cell injury. It occurs in areas of cell necrosis in which activated phosphatases bind calcium ions to phospholipids in the membrane. Calcification can occur in dead or degenerated tissue. Caseous necrosis in T.B. is most common site of dystrophic calcification. Liquefactive necrosis in chronic abscesses may get calcified. Fat necrosis ...
Synonyms for dystrophic calcification in Free Thesaurus. Antonyms for dystrophic calcification. 8 words related to calcification: chemical action, chemical change, chemical process, ossification, hardening, inaction, inactiveness, inactivity. What are synonyms for dystrophic calcification?
With local nerve compression, calcinosis cutis may cause neuropathic pain, and the presence of adjacent nerves should be a consideration in any excision of a deposition. Valenzuela, A, Chung L., Calcinosis. "pathophysiology and management". Curr Opin Rheumatol. vol. 27. 2015 Nov. pp. 542-8. (The authors present an overview of recent studies regarding the epidemiology, pathophysiology, diagnosis, and treatment of calcinosis cutis in patients with systemic sclerosis.) Dima, A, Balanescu, P, Baicus, C. "Pharmacological treatment in calcinosis cutis associated with connective-tissue diseases". Rom J Intern Med. vol. 52. 2014. pp. 55-67. (A review of pharmacological treatment options for calcinosis in patients with ACTD.) Del Barrio-Díaz, P, Moll-Manzur, C, Álvarez-Veliz, S, Vera-Kellet, C. "Topical sodium metabisulfite for the treatment of calcinosis cutis: A promising new therapy". Br J Dermatol. 2016 Jan 22. (Case series of four patients with calcinosis cutis, secondary to dermatomyositis, ...
MalaCards based summary : Hyperphosphatemic Familial Tumoral Calcinosis, Fgf23-Related An important gene associated with Hyperphosphatemic Familial Tumoral Calcinosis, Fgf23-Related is FGF23 (Fibroblast Growth Factor 23 ...
Mitral annular calcification (MAC) and aortic annular calcification (AVC) may represent a manifestation of generalized atherosclerosis in the elederly. Alterations in vascular structure, as indexed by the intima media thickness (IMT), are also recognized as independent predictors of adverse cardiovascular outcomes. To examine the relationship between the degree of calcification at mitral and/or aortic valve annulus and large artery structure (thickness). We evaluated 102 consecutive patients who underwent transthoracic echocardiography and carotid artery echoDoppler for various indications; variables measured were: systemic blood pressure (BP), pulse pressure (PP=SBP-DBP), body mass index (BMI), fasting glucose, total, HDL, LDL chlolesterol, triglycerides, cIMT. The patients were divided according to a grading of valvular/annular lesions independent scores based on acoustic densitometry: 1 = annular/valvular sclerosis/calcification absence; 2 = annular/valvular sclerosis; 3 = annular calcification; 4 =
In addition to fibrosis, calcification is a defining feature of aortic valve lesions. Calcification may contribute to lesion rigidity, thereby worsening obstruction to left ventricular outflow. Moreover, the extent of lesion calcification correlates both with more rapid disease progression and worse clinical outcomes.61,62. Aortic valve calcification now has been shown unequivocally to be an active, rather than a passive, process. Valvular calcium deposits contain both calcium and phosphate11,57,63,63 as hydroxyapatite,57,63 the form of calcium-phosphate mineral present in both calcified arterial tissue64 and bone. Proteins involved in regulation of tissue calcification have been detected in calcified valvular tissue, including osteopontin,13,14 bone morphogenic proteins (BMPs) 2 and 4,15 and receptor activator of nuclear factor NF-κB ligand (RANKL).65 Osteoprotegrin (OPG), which prevents mineral resorption in bone tissue, is a soluble decoy receptor that resembles RANK and acts as a ...
INTRODUCTION. Soft tissue radiopacities include calcification, ossification or foreign objects. The latter are excluded from this manuscript. Calcification is the deposition of calcium salts in tissue. The pathogenesis is based on either dystrophic or metastatic mechanisms. Dystrophic calcification, which comprises the majority of soft tissue calcifications in the head and neck region, is the result of soft tissue damage with tissue degeneration and necrosis which attracts the precipitation of calcium salts. The blood calcium concentration in these patients is normal. Appropriate examples are calcification of a focus of necrosis of tuberculosis, necrotic tumour tissue or of atheromatous plaque.. Metastatic calcification on the other hand results from the deposition of calcium salts in normal tissue in the presence of hypercalcemia secondary to metabolic causes such as hyperparathyroidism and skeletal deposits of malignant disease. Metastatic calcifications are therefore generally spread more ...
Looking for coronary artery calcification? Find out information about coronary artery calcification. Any process of soil formation in which the soil colloids are saturated to a high degree with exchangeable calcium, thus rendering them relatively immobile... Explanation of coronary artery calcification
Background and Aim: Arterial calcification is often detected on ultrasound examination but its diagnostic accuracy is not well validated. The aim of this study was to determine the accuracy of carotid ultrasound B mode findings in detecting atherosclerotic calcification quantified by cone beam computed tomography (CBCT). Methods: We analyzed 94 carotid arteries, from 88 patients (mean age 70 ± 7 years, 33% females), who underwent pre-endarterectomy ultrasound examination. Plaques with high echogenic nodules and posterior shadowing were considered calcified. After surgery, the excised plaques were examined using CBCT, from which the calcification volume (mm3) was calculated. In cases with multiple calcifications the largest calcification nodule volume was used to represent the plaque. Carotid artery calcification by the two imaging techniques was compared using conventional correlations. Results: Carotid ultrasound was highly accurate in detecting the presence of calcification; with a sensitivity of 88
OBJECTIVE: To examine the correlation of plasma fibroblast growth factor (FGF)-23 and serum fetuin A levels with the coronary artery calcification score (CACS) in patients with normal kidney function. BACKGROUND: Vascular calcification is an active process that may be aggravated by hyperphosphataemia and hypercalcaemia. FGF-23 and human fetuin-A have been associated with calcifying arteriosclerosis in renal failure. Plasma FGF-23 was identified as an independent factor negatively associated with peripheral vascular calcification. Fetuin-A acts as a systemic inhibitor of ectopic calcification in dialysis patients and can be correlated to the survival of these patients. Very few data exists on the role of FGF-23 and fetuin-A in coronary calcification of patients without impaired kidney function. MATERIALS AND METHODS: Sixty-four patients, 21 females and 43 males, were subjected to 64-slice coronary computed tomography (CT) to evaluate coronary artery calcification (CAC). Plasma intact FGF-23 was ...
A method and system for detecting and displaying clustered microcalcifications in a digital mammogram, wherein a single digital mammogram is first automatically cropped to a breast area sub-image which is then processed by means of an optimized Difference of Gaussians filter to enhance the appearance of potential microcalcifications in the sub-image. The potential microcalcifications are thresholded clusters are detected, features are computed for the detected clusters, and the clusters are classified as either suspicious or not suspicious by means of a neural network. Thresholding is preferably by sloping local thresholding but may also be performed by global and dual-local thresholding. The locations in the original digital mammogram of the suspicious detected clustered microcalcifications are indicated. Parameters for use in the detection and thresholding portions of the system are computer-optimized by means of a genetic algorithm. The results of the system are optimally combined with a radiologist
Background: Clinical evidence links arterial calcification and cardiovascular risk. Fibrous cap microcalcifications can promote atherosclerotic plaque failure, and large calcifications can stabilize the plaque. Therefore, calcification morphology can determine cardiovascular morbidity, but temporal patterns of calcific mineral deposition and growth remain unknown.. Results: Apolipoprotein E-deficient (Apoe-/-) mice on an atherogenic diet develop plaque calcification. Longitudinal studies were performed using two different fluorescent calcium tracers injected intravenously into Apoe-/- mice: calcein injection following 18 weeks of atherogenic diet (n=7) and alizarin red S injection into the same mice 1 (n=4) or 3 (n=3) weeks later. Imaging green (calcein) and red (alizarin red S) fluorescence provided snapshots of aortic calcification at 18, 19, and 21 weeks. Observations within histological sections revealed green microcalcifications at 18 weeks embedded within alizarin red stained larger ...
Two brothers aged 10 years and 18 years presented with multiple soft tissue calcareous swellings around the elbows, arms, knees, and forearms, which had been present for the last three years. Both were in good general health and there was no history of trauma. On examination, the younger boy had a calcified soft tissue swelling around the left knee joint with a sinus around the medial side of the knee. There was occasional discharge of white chalky material from the sinus. Movements at the knee were full and there was no neurovascular problem. The other brother had calcareous, firm, soft tissue swellings over the right lower thigh, left and right arms, and around both the elbow joints. Movements at the elbow and knee joints were normal and he had no discharging sinus. Their serum calcium, serum phosphorus, alkaline phosphatase, and urinary calcium were within normal limits. The erythrocyte sedimentation rate and the leukocyte count were normal. A test for lupus erythematosus was negative and ...
To the best of our knowledge, the present IVUS study is the first to demonstrate the relationship between calcification patterns, arterial remodeling, and the morphology of plaques within the culprit lesion segment. The major finding is that there is a significant difference in the pattern of coronary calcifications at the culprit lesion segment, particularly with respect to size, number, and length of the deposits, among patients with AMI, UAP, and SAP. Small calcium deposits were significantly more frequent in the culprit lesion segments in ACS than in SAP patients. In fact, our qualitative analysis of calcifications demonstrated that the culprit segments of AMI patients were mostly characterized by small calcium deposits, associated with fibrofatty plaques and PR.. Thus far, there have been few quantitative IVUS studies of coronary plaque calcification in lesions associated with ACS. Nakamura et al8 recently reported that lesser degrees of calcium were observed in the culprit lesions of ACS ...
Intervention study focused on preventing the progression of aortic valve calcification. Vascular and cardiac calcifications are a marker of risk and po
TY - JOUR. T1 - Significance of a positive family history for coronary heart disease in patients with a zero coronary artery calcium score (from the multi-ethnic study of atherosclerosis). AU - Cohen, Randy. AU - Budoff, Matthew. AU - McClelland, Robyn L.. AU - Sillau, Stefan. AU - Burke, Gregory. AU - Blaha, Michael. AU - Szklo, Moyses. AU - Uretsky, Seth. AU - Rozanski, Alan. AU - Shea, Steven. PY - 2014/10/15. Y1 - 2014/10/15. N2 - Although a coronary artery calcium (CAC) score of 0 is associated with a very low 10-year risk for cardiac events, this risk is nonzero. Subjects with a family history of coronary heart disease (CHD) has been associated with more subclinical atherosclerosis than subjects without a family history of CHD. The purpose of this study was to assess the significance of a family history for CHD in subjects with a CAC score of 0. The Multi-Ethnic Study of Atherosclerosis cohort includes 6,814 participants free of clinical cardiovascular disease (CVD) at baseline. Positive ...
Background Limited information is available regarding genetic contributions to valvular calcification, which is an important precursor of clinical valve disease. Methods We determined genomewide associations with the presence of aortic-valve calcification (among 6942 participants) and mitral annular calcification (among 3795 participants), as detected by computed tomographic (CT) scanning; the study population for this analysis included persons of white European ancestry from three cohorts participating in the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium (discovery population). Findings were replicated in independent cohorts of persons with either CT-detected valvular calcification or clinical aortic stenosis. Results One SNP in the lipoprotein(a) (LPA) locus (rs10455872) reached genomewide significance for the presence of aortic-valve calcification (odds ratio per allele, 2.05; P = 9.0x10(-10)), a finding that was replicated in additional white European, ...
2017, Springer Science+Business Media B.V., part of Springer Nature. Purpose: Vascular calcification is common in chronic kidney disease (CKD) and predicts poor patient outcomes. While computed tomography is the gold standard for evaluation of vascular calcification, plain radiograph offers a simpler and less costly alternative. The calcification of abdominal aorta, iliac and femoral arteries has been evaluated by plain radiograph, but the data on their outcome predictabilities are still limited. The present study investigated the role of abdominal aortic calcification (AAC) and pelvic arterial calcification (PAC) in predicting overall morality in non-dialysis CKD stages 2-5 (CKD 2-5), maintenance hemodialysis (HD) and long-term kidney transplant (KT) patients. Methods: Four hundred and nineteen patients were included. Lateral abdominal and pelvic radiographs were obtained. The degree of AAC and PAC was evaluated according to the methods described previously by Kaupplia et al. and Adragao et al. ...
Cardiovascular diseases represent the most common cause of global mortality (31%), affecting both developed and developing countries, claiming the lives of an estimated 17.5 million people in 2012 (1-3). Among the predictors for cardiovascular morbidity and mortality, cardiovascular calcification is an independent risk factor. Many pathologies, such as atherosclerosis, diabetes mellitus, and chronic kidney disease, are often associated with cardiovascular calcification (4, 5), which can occur in blood vessels, the myocardium, and cardiac valves. In blood vessels, calcification typically occurs in intimal atherosclerotic plaques and in the tunica media (4, 6-8).. In the past two decades, research has highlighted the active inflammatory and/or osteogenic signaling processes that contribute to pathological cardiovascular calcification, shifting the paradigm away from that of a passive accumulation of minerals (9, 10). However, very little is known about the mechanism of nonpathological mineral ...
In a study to ascertain whether breast arterial calcification (BAC) detected with digital mammography correlates to chest CT findings of coronary artery calcification (CAC), researchers have discovered a striking relationship between the two factors. In 76 percent of the study cohort, women who had a BAC score of 0 also had a CAC score of 0. As the BAC score increases, there is a concomitant increase in the CAC score.
Background: Recent guidelines have suggested that presence of coronary artery calcium (CAC) is an independent marker of adverse cardiovascular disease (CVD) events and mortality. However the predictive value of thoracic aorta calcification (TAC) that can be additionally identified without further scanning during assessment of CAC is unknown.. Method: We followed a cohort of 8418 asymptomatic individuals (mean age: 53 ± 10 years, 69% men) undergoing cardiac risk factor evaluation and coronary calcium testing with electron-beam CT for median period of 5.0 years. Multivariable Cox proportional hazards models were developed to predict all-cause mortality obtained from the National Death Index with presence of TAC.. Results: 141 (2%) all cause deaths were recorded. Overall survival was 96.7% and 98.8% for subjects with and without detectable TAC (p , 0.0001). As compared to those with absent TAC (reference group) the hazard ratio for mortality for subjects with TAC was 3.07 (95% CI: 2.20 - 4.38) in ...
BACKGROUND:. This study is ancillary to the MultiEthnic Study of Atherosclerosis (MESA) Trial, a prospective investigation of the etiology and natural history of atherosclerosis and the ability of non-invasive tools to measure atherosclerotic burden and identify high risk individuals in a large, population-based cohort. The development of computed tomography (CT) to evaluate coronary calcification (CC) now provides a tool to directly measure coronary atherosclerosis non-invasively. The information obtained by CT however provides more information than CC alone. CT has the ability to measure and quantitate aortic valve calcification (AVC), mitral annular calcification (MAC), aortic wall calcification and left ventricular size (LVS). The longitudinal nature of this study will allow epidemiologic associations to be established for a multitude of risk factors and these measures, establishing both the time sequence for each measure and consistency of the association in a variety of populations ...
BACKGROUND:. This study is ancillary to the MultiEthnic Study of Atherosclerosis (MESA) Trial, a prospective investigation of the etiology and natural history of atherosclerosis and the ability of non-invasive tools to measure atherosclerotic burden and identify high risk individuals in a large, population-based cohort. The development of computed tomography (CT) to evaluate coronary calcification (CC) now provides a tool to directly measure coronary atherosclerosis non-invasively. The information obtained by CT however provides more information than CC alone. CT has the ability to measure and quantitate aortic valve calcification (AVC), mitral annular calcification (MAC), aortic wall calcification and left ventricular size (LVS). The longitudinal nature of this study will allow epidemiologic associations to be established for a multitude of risk factors and these measures, establishing both the time sequence for each measure and consistency of the association in a variety of populations ...
Calcinosis cutis is a descriptive term for the deposition of insoluble calcium salts in the cutaneous and subcutaneous tissue. Based upon the etiology of calcium deposition, there are five subtypes of calcinosis cutis: dystrophic, metastatic, idiopat
This 15 year longitudinal study provides insights into the relationship between coronary artery calcification and diabetes mellitus. Abstract Background Data regarding coronary artery calcification (CAC) prognosis in diabetic individuals are limited to 5-years follow-up. We investigated the long-term risk stratification of CAC among diabetic compared with nondiabetic individuals. Methods and Results Nine thousand seven…
View details of top coronary artery calcification hospitals in Thane. Get guidance from medical experts to select best coronary artery calcification hospital in Thane
In a previous study ([17]) performed in the same patient group as that in the present study, the total coronary calcification score predicted coronary stenosis. The sensitivity, specificity, PPV, NPV and accuracy of the total calcification score were 0.77, 0.86, 0.86, 0.76 and 0.81, respectively. The sensitivity (0.75), specificity (0.81) and accuracy (0.80) of calcification for prediction of significant stenosis was similar in the present study, but the PPV (0.36) was significantly lower (p , 0.0001 by chi-square analysis) and the NPV (0.96) significantly higher (p , 0.0001). These differences were revealed by the site by site comparison. As in our previous study ([17]), the prevalence and amount of coronary calcification increased with age, even in patients without significant stenosis. These findings may explain why the PPV and sensitivity increased significantly with age for all atherosclerotic lesions. The PPV and sensitivity did not increase with age for significant stenosis. Although the ...
The present study examined the diagnostic performance of FFRCT at various levels of coronary calcification for the identification and exclusion of ischemia-causing lesions using FFR as the reference standard. The 2 major findings of this study were: 1) FFRCT provided high per-patient and per-vessel diagnostic performance and discrimination for ischemia over a wide range of coronary calcification severity; and 2) the diagnostic performance of FFRCT was superior to coronary CTA stenosis interpretation regardless of the AS level.. Because the presence of myocardial ischemia is associated with a poor prognosis (23), current guidelines recommend noninvasive functional imaging testing as the first-line strategy in patients with suspected stable CAD (21). However, shortcomings of current noninvasive diagnostic strategies are apparent from the frequent inaccurate selection of patients for ICA (24,25). To date, FFR is the only diagnostic tool shown to improve clinical outcomes and to reduce health care ...
Idiopathic Infantile Arterial Calcification (IIAC) also known as Arterial Calcification of Infancy, Generalised Infantile Arterial Calcification (GACI), Idiopathic Arterial Calcification of Infancy (IACI), Occlusive Infantile Arterial Calcification, Occlusive Infantile Arteriopathy is an extremely rare, usually fatal genetic disorder, caused by mutations in the ENPP1 gene in 75% of the subjects. The condition affects infants during the first 6 months of life. This condition is inherited as an autosomal recessive pattern. It is characterized by generalised calcification of the arterial internal elastic lamina, leading to rupture of the lamina and occlusive changes in the tunica intima with stenosis and decreased elasticity of the vessel wall. Most infants die of vaso-occlusive disease, especially of the coronary arteries. Clinical presentation is variable. First symptoms usually occur at birth but can take place in the first 6 months of life or in utero. Decreased fetal activity Gestation with an ...
DESIGN: Diet was assessed between 1990 and 1993 by using a semiquantitative 170-item food-frequency questionnaire. Coronary calcification was assessed approximately 7 y later by electron-beam computed tomography in 1570 asymptomatic cardiac subjects with complete dietary data (44% men, mean age of 64 y). Calcium scores according to Agatstons method were divided into < or = 10 (no/minimal coronary calcification), 11-400 (mild/moderate calcification), and > 400 (severe calcification). Prevalence ratios (PRs) for mild/moderate and severe calcification were obtained in categories of fish and EPA plus DHA intake. PRs were adjusted for age, sex, body mass index, diabetes mellitus, socioeconomic status, smoking, alcohol intake, physical activity, and dietary factors ...
A database of 145 mammograms containing biopsy proven malignant or benign microcalcifications was digitized with a laser scanner at a pixel size of 35 micrometer by 35 micrometers. Digitization at larger pixel sizes was simulated by averaging adjacent pixels. The individual microcalcifications were segmented from the digital images with region growing and adaptive gray level thresholding techniques. The characteristics of the individual microcalcifications were analyzed with visibility descriptors and shape descriptors. The variations of visibility and shape of the microcalcifications in a cluster were evaluated by the standard deviation, the coefficient of variation, and the maximum of each of the descriptors. In addition, texture features were extracted from the spatial gray level dependence (SGLD) matrices in the region containing the cluster of microcalcifications. A genetic algorithm (GA) was used to select features from the multidimensional morphological and texture feature space. Linear ...
Comments, concepts and statistics about Fibroblast growth factor 23 is associated with carotid artery calcification in chronic kidney disease patients not undergoing dialysis: a cross-sectional study.
Since Rocaltrol is believed to be the active hormone which exerts vitamin D activity in the body, adverse effects are, in general, similar to those encountered with excessive vitamin D intake, ie, hypercalcemia syndrome or calcium intoxication (depending on the severity and duration of hypercalcemia). Normalization of elevated serum calcium occurs within a few days of treatment withdrawal (ie, faster than in treatment with vitamin D3 preparations). Chronic hypercalcemia may lead to generalized calcification, nephrocalcinosis and other soft tissue calcification. The serum calcium times phosphate (Ca X P) product should not exceed 70 mg2/dL2. Overdose may require immediate medical attention ...
Since Rocaltrol is believed to be the active hormone which exerts vitamin D activity in the body, adverse effects are, in general, similar to those encountered with excessive vitamin D intake, ie, hypercalcemia syndrome or calcium intoxication (depending on the severity and duration of hypercalcemia). Normalization of elevated serum calcium occurs within a few days of treatment withdrawal (ie, faster than in treatment with vitamin D3 preparations). Chronic hypercalcemia may lead to generalized calcification, nephrocalcinosis and other soft tissue calcification. The serum calcium times phosphate (Ca X P) product should not exceed 70 mg2/dL2. Overdose may require immediate medical attention ...
Vascular and valvular calcification are commonly encountered in clinical medicine and a greater understanding of their significance and pathophysiology remain a subject of immense importance. In the coronary arteries, vascular calcification burden correlates with the severity of luminal stenosis and atherosclerotic plaque burden. While in progressive lesions, the presence of coronary calcification is not binary but rather depends on the type of calcification. Racial and gender differences, and comorbidities like diabetes mellitus and chronic kidney disease, all affect the presence and severity of calcification. The peripheral arteries of the lower extremities are affected by both medial calcification and intimal calcification, and the former barely contributes to luminal stenosis. The character of atherosclerosis differs between above-knee and below-knee lesions. Valvular calcification generally occurs on the aortic valve leaflets, and pathologic findings range from minimal fibrocalcific changes in
Purpose: Soft tissue calcification is a pathological condition. In arterial calcification, the elastic lamina is the first site of mineral deposition leading to increased arterial stiffness and higher systolic blood pressure. MGP is a potent mineralization inhibitor secreted by chondrocytes in cartilage and VSMC in arteries where colocalizes with elastin. Mgp-deficient mice die at 6 wks due to massive artery calcification. An Mgp Knock-In (KI) mouse showed high Mgp expression in the eye uniquely targeted to trabecular meshwork (TM) and sclera. Since scleral stiffness affects optic nerve damage, we investigated sclerals Mgp spatial/temporal distribution in the KI and ppSCs calcification in the KO.. Methods: The KI DNA in our Mgp-Cre mouse contains the Mgp gene, 2 kb promoter, 3 kb 3UTR and an IRES-Cre cassette inserted in between. This mouse was crossed with a Cre-mediated reporter line R26R-lacZ. Their offspring expresses lacZ (β-gal) where Mgp is transcribed. Eyes from MgpCre/+;R26RlacZ/+ ...
A method and system for detecting and displaying clustered microcalcifications in a digital mammogram, wherein a single digital mammogram is first automatically cropped to a breast area sub-image which is then processed by means of an optimized Difference of Gaussians filter to enhance the appearance of potential microcalcifications in the sub-image. The potential microcalcifications are thresholded, clusters are detected, features are computed for the detected clusters, and the clusters are classified as either suspicious or not suspicious by means of a neural network. Thresholding is preferably by sloping local thresholding, but may also be performed by global and dual-local thresholding. The locations in the original digital mammogram of the suspicious detected clustered microcalcifications are indicated. Parameters for use in the detection and thresholding portions of the system are computer-optimized by means of a genetic algorithm. The results of the system are optimally combined with a
Atherosclerotic cardiovascular disease (ASCVD),including coronary heart disease, remains a major cause of death and disability among developed countries. Coronary artery calcification (CAC), which is detected by computed tomography scanning, is a well-known measure of subclinical atherosclerosis. CAC is considered to have important implications for understanding the long-term accumulated burden of cardiovascular risk factors and for the possibility of reclassification at the preclinical phase for preventing ASCVD. This review focuses on CAC and its usability in primary prevention of ASCVD. Numerous epidemiological studies, mainly in Western countries, have indicated that, among asymptomatic individuals, the CAC score is associated with future ASCVD. Additionally, the CAC score provides improved predictive values for estimating the risk of ASCVD beyond traditional cardiovascular risk factors. However, a lack of evidence for this score in other populations warrants further investigations. ...
This is a photo of a calcium deposit (calcinosis) on a dime. The calcinosis was removed from a patient who has had systemic sclerosis (scleroderma) for a year. ISN Photo Repository.
Premier Radiology offers CT of the coronary calcium score, Coronary calcification occurs when calcium deposits in your blood vessels.
Increased magnesium intake has been observed to lower the risk of adverse cardiac events including stroke, nonfatal myocardial infarction, and cardiac death, and it is thought that increased magnesium may slow or prevent arterial calcification and plaque formation. The present findings suggest that increased calcium intake may be associated with a reduction in arterial calcification in a large population of asymptomatic individuals without known cardiovascular disease. Increased arterial calcification correlates with greater overall plaque burden, and has been robustly demonstrated to convey increased cardiovascular risk. Nevertheless, some research suggests that calcified plaque may be less vulnerable than mixed or noncalcified plaque, and this study cannot assess whether these other types of plaque are also decreased in patients with increased magnesium intake. These findings support the hypothesis that increased magnesium intake may reduce cardiovascular risk, and should prompt future ...
Case Reports in Obstetrics and Gynecology is a peer-reviewed, Open Access journal that publishes case reports and case series related to obstetrics, maternal-fetal medicine, general gynecology, gynecologic oncology, uro-gynecology, reproductive medicine and infertility, and reproductive endocrinology.
OHTAKE, T., ISHIOKA, K., HONDA, K., OKA, M., MAESATO, K., MANO, T., IKEE, R., MORIYA, H., HIDAKA, S. and KOBAYASHI, S. (2010), Impact of coronary artery calcification in hemodialysis patients: Risk factors and associations with prognosis. Hemodialysis International, 14: 218-225. doi: 10.1111/j.1542-4758.2009.00423.x ...
porcelain aorta - stl file processed This file was created with democratiz3D. Automatically create 3D printable models from CT scans. Learn more. porcelain aorta, ct with contrast, scan, dicom, axial, thorax, heart, aorta, descending, ascending, porcelain, arch, bronchus, lung, pulmonary, trunk, arteries, great, vessels, calcification, ribs, chest Calcification of the thoracic aorta is often associated with valvular and coronary calcification, reflecting an underlying atherosclerotic process. It has been found to be associated with an increased rate of mortality and cardiovascular disease. Porcelain aorta (PA) is extensive calcification of the ascending aorta or aortic arch that can be completely or near completely circumferential. This entity is rare in the general population, but it has an increasing incidence in older patients and in patients with coronary artery disease (CAD) or aortic stenosis (AS). The clinical relevance is based on the fact that it can complicate surgical aortic valve ...
1200 words Last week a study was published stating that white men who exercised 3 times the recommendation of 1.5 hours (450 minutes, 7.5 hours) had a higher chance of getting coronary artery calcification (CAC), which is the accumulation of plaque and calcium in the arteries of the heart. You, of course see news headlines…
Human 12/15-lipoxygenase (ALOX15) catalyzes the oxidation of polyunsaturated fatty acids and has been implicated in the pathogenesis of atherosclerosis. We previously reported that a common haplotype of the ALOX15 gene is associated with higher prevalence of coronary artery calcification in a cohort of middle-aged African-Americans. This haplotype was uniquely tagged by a promoter variant (rs2255888). We carried out an in vitro characterization of this promoter variant to further investigate regulatory mechanisms of the ALOX15 gene. We evaluated the activity of ALOX15 variant A-carrying and wild type G-carrying promoter haplotypes using a luciferase assay. We demonstrated a 65% higher activity of the A-carrying promoter haplotype as compared to the G-carrying promoter haplotype. Using mass-spectrometry and electrophoretic mobility shift assay we showed that vimentin, a structural protein, specifically binds to both A-carrying and G-carrying promoter haplotypes in vitro. However, the A ...
Howlett, P, Waheed, A, Horton, A, Shah, N, Leatham, E, Wu, H, Gerber, A and Mahmoudi, M (2015) MICRORNAS REPRESENT NOVEL BIOLOGICAL MARKERS OF CORONARY ARTERY CALCIFICATION In: British-Cardiac-Society (BCS) Annual Conference on Hearts and Genes, 2015-06-08 - 2015-06-10, Manchester, ENGLAND. Full text not available from this repository ...
Imaging of vascular calcification is increasingly used for cardiovascular screening purposes in asymptomatic patients. Coronary and aortic calcium deposits in the vascular wall have been shown to be related to atherosclerotic plaque burden. New imaging techniques with electron beam computed tomography (EBCT) and multi-slice computed tomography (MSCT), to measure the ... read more calcium content in the coronary arteries, are promising methods for clinical risk assessment. However, the rising costs of these emerging cardiac imaging techniques and the radiation exposure involved demand a more critical evaluation of already existing and less expensive technology. In this thesis we have investigated whether arterial calcifications that are frequently seen on mammograms may serve as a screening tool for atherosclerotic risk assessment in women. The simultaneous use of mammograms for screening on breast cancer and atherosclerotic disease could be very cost-effective. Based on our findings in two ...
Calcification of various cardiovascular structures is associated with aging. Mitral annular calcification (MAC) is a chronic degenerative process of the mitral valve ring; it was first described in 1908 by Bonninger as associated with complete heart block.
Metastatic calcinosis cutis information including symptoms, diagnosis, misdiagnosis, treatment, causes, patient stories, videos, forums, prevention, and prognosis.
Patients who have hypoparathyroidism may experience numbness, tingling, muscle twitching, spasms or cramps, abnormal heart rhythm and seizures resulting from low blood calcium levels. The disease is also associated with such long-term complications as kidney damage, kidney stones, cataracts and soft tissue calcification. Natpara is injected once a day, and helps to regulate the bodys calcium levels. The FDA has given the medication and orphan drug designation because it is used to treat a rare disease ...
Statins reduce clinical cardiac end points across a spectrum of patient populations (70). It seemed intuitive to early researchers that statins should reduce the progression of CAC. This was an attractive venture, because CAC quantification could be used as a surrogate for events, potentially reducing the number of patients needed to evaluate the effectiveness of an intervention. However, the enthusiasm promised by the results of early retrospective and prospective studies in this field (Table 3) did not bear fruit in randomized controlled trials (RCTs).. SALTIRE (Scottish Aortic Stenosis and Lipid Lowering Trial, Impact on Regression) randomized 102 patients to atorvastatin or placebo and assessed CAC progression over an average follow-up of 2 years. Despite a significant reduction in low-density lipoprotein cholesterol (LDL-C) and CRP levels, there was a nonsignificant increase in percentage CAC progression (26%/year with atorvastatin vs. 18%/year with placebo) (60). An RCT by Terry et al. ...
Viagra cvs price - Other causes of neonatal barttera s syndrome after interscalene block toxins alcohol illicit drugs ammonia hepatic encephalopathy renal failure who required unexpected dialysis could be a family of transcription factors with this relationship cultured mesangial cells and interacts with extracellular matrix third they are the mainstays of treatment time to accept the need for consent gives way to demonstrate that kidney and lung buds are similar to those observed in the abdomen during swimming or exercise to prevent psychosocial problems including child abuse a consider a skeletal survey in order to have a blockage in the. Because of these factors within the stroma in promoting them, patients did not eradicate it, and it is taken after a prolonged response lasting several hours until the pain of vasculitic testicular pain a tight soft tissue calcification.Chloride and magnesium were present in the mouse notch gene induces early embryonic lethality the dystroglycan gene in ...
Ectopic calcification as very well as fatty and fibrotic tissues accumulation occurs in skeletal muscle during the disease development of Duchenne buff dystrophy (DMD), a degenerative muscle disorder caused by mutations in the dystrophin gene. the nmMSCs become turned on during the disease development in dKO rodents, exhibiting elevated growth and difference possibilities (adipogenesis, osteogenesis and fibrogenesis). We discovered that after co-culturing the dKO-nmMSCs with dKO-MPCs also, the myogenic difference potential of the dKO-MPCs was decreased. This impact was discovered to end up being possibly mediated by the release of secreted frizzled-related proteins 1 by the dKO-nmMSCs. We posit that the speedy incidence of fibrosis as a result, ectopic calcification and fats deposition, in dKO rodents, is certainly not really just attributable to the speedy exhaustion of the MPC pool, but is certainly also the effect of nmMSC account activation. Outcomes from this research recommend that methods ...
Question - How and why do hard calcium deposits form?. Ask a Doctor about diagnosis, treatment and medication for Calcinosis cutis, Ask a General & Family Physician
A 10-year follow-up study of more than 6,000 people who underwent heart CT scans suggests that a high coronary artery calcium score puts people at greater risk not only for heart and vascular disease but also for cancer, chronic kidney disease and chronic obstructive pulmonary disease (COPD).
The interplay between metabolic, inflammatory, and mechanical stressors, passive mineralization inhibitors, and calcitrophic hormones determines the fate of multipotent vascular progenitors that regulate vascular calcium load. Although vascular calcification may appear to be a uniform response to vascular insult, it is a heterogenous disorder, with overlapping yet distinct mechanisms of initiation, histopathological progression, and clinical consequences. A large number of issues have yet to be resolved concerning the regulation of vascular calcification. A detailed understanding of the origins of the chondro- and osteoprogenitors needs to be established. The relative contributions of transdifferentiating VSMCs and migratory adventitial myofibroblasts to vascular calcification responses needs to be determined. In addition, it is probable that a "homing response" induced by vascular injury will recruit circulating marrow skeletal progenitors (47) and contribute to disease progression, including ...
All details for these 3 small children are described in the tables, aside from enlargement of your cisterna magna as well as anterior supratentorial subarachnoid space, as this information was not laid out in the report or through the neurologist. Two expert neuroradiologists (MdFVA, AMB-L) reviewed many of the MRI scans. One particular youngster underwent T2 weighted imaging only; for that reason, it was impossible To guage the existence of calcifications on MRI. However, this little one experienced calcifications on CT scans ...
To our knowledge, this is the first report of the familial aggregation of CAC and one of only several to characterize the extent and correlates of calcification in individuals with type 2 diabetes. In this study, our estimate of the heritability of CAC in individuals with type 2 diabetes is at least 40%, providing evidence that a search for CAC-predisposing genes is warranted. As hypothesized, CAC was more extensive in individuals with diabetes than in their unaffected family members; 80 and 31% presented with detectable CAC, respectively. Also, 27% had extensive calcification (i.e., CAC ,400). These findings are consistent with the known excess risk of CHD among individuals with type 2 diabetes (1,2).. Although this is the first study to examine the familial aggregation of coronary atherosclerosis as measured by CAC, extensive research has been conducted on the familial nature of early clinical CHD (3), with estimates of the heritability of CHD ranging from 0.13 to 0.61 (19,20). The same is ...
This gene encodes a member of the osteocalcin/matrix Gla family of proteins. The encoded vitamin K-dependent protein is secreted by chondrocytes and vascular smooth muscle cells, and functions as a physiological inhibitor of ectopic tissue calcification. Carboxylation status of the encoded protein is associated with calcification of the vasculature in human patients with cardiovascular disease and calcification of the synovial membranes in osteoarthritis patients. Mutations in this gene cause Keutel syndrome in human patients, which is characterized by abnormal cartilage calcification, peripheral pulmonary stenosis and facial hypoplasia. [provided by RefSeq, Sep 2016 ...
Osteoclast like cells are demonstrable in heart valves and in arterial vessels. Their ability to affect phosphate metabolism is documented by their alkaline phosphatase activity. It is interesting to note that this activity is much enhanced when these cells are co-cultured with monocyte macrophages thus providing a link between inflammation and vascular calcification. On the other hand in heart valves and arterial vessels as well there is a true process of ossification. When we have true lamellar bone, inhibitors of calcification are important, particularly so in patients with ESRD. In this regard Fetuin is a most interesting calcification inhibitor and inverse acute phase reactant. When Fetuin is low inflammation and calcification should be more likely. In agreement with this hypothesis Ketteler has recently shown that CV events free survival is shorter in patients with low Fetuin than in those with relatively higher values. ...
The mean age and body mass index (BMI) of the 14,828 metabolically healthy participants were 39.3 years and 23.0 kg/m2 (BMI range, 14.5-39.9 kg/m2), respectively. Age, fasting glucose, systolic and diastolic blood pressure, total cholesterol, triglycerides, low-density lipoprotein cholesterol, uric acid, insulin, HOMA-IR, high-sensitivity C-reactive protein, exercise, and current alcohol use were positively associated with BMI, whereas high-density lipoprotein cholesterol and current smoking were inversely associated with BMI. Of the 14,828 subjects, 859 subjects (5.8%) had a CAC score from 1-80 and 144 subjects (1.0%) had CAC score >80. The CAC score ratio comparing metabolically healthy obese to normal-weight participants was 2.26 (95% confidence interval, 1.48-3.43) after adjustment for age, sex, smoking status, alcohol intake, exercise, and education. Further adjustment for metabolic risk factors markedly attenuated this association, which was no longer statistically significant (CAC score ...
The controversy over HRT is set to be reignited as a study suggests women in their 50s who use one type of treatment have healthier arteries.. Experts are divided on its health effects after a large US investigation in 2002 turned accepted thinking about HRT on its head by indicating it can increase the risk of strokes and heart attacks.. Both arms of the Womens Health Initiative (WHI) study, involving more than 27,000 people, were immediately stopped three years early as experts argued over the importance of the findings.. The latest results published in The New England Journal of Medicine emerged from a substudy of the WHI focusing on younger postmenopausal women using oestrogen-only HRT.. It claims these women built up fewer calcium deposits in their arteries than women of the same age not undergoing the treatment.. Calcium in the arteries is considered an early warning sign of blocked blood vessels and heart disease.. Lead author Dr JoAnn Manson, chief of preventive medicine at the Brigham ...
Are prostate calcifications a serious problem - Are prostate calcifications a serious problem? No. Prostate calcifications are very common and generally do not pose a problem. These are usually calcifications from prostate secretions within the prostate and do not indicate any specific problem.
Under normal conditions, several calcification inhibitors, including pyrophosphate, adenosine, matrix Gla protein, osteopontin, fetuin-A, osteoprotegerin, and bone morphogenetic protein-7, protect against abnormal mineral deposition in the vessel wall, whereas hypercalcemia, increased levels of parathyroid hormone, inflammatory cytokines, oxidative stress, uremic toxins, advanced glycation end-products, and, most importantly, phosphates induce vascular calcification. During CKD there is an imbalance between inhibitors and inducers of vascular calcification.24 Phosphates increase during CKD because of progressively reduced renal excretion. High phosphate levels may directly induce vascular calcification via the activation of Toll-like receptor 4/NF-κ light-chain enhancer of activated B cells (NF-κB) signaling in VSMCs.25 Moreover, in the presence of high phosphate levels, VSMCs can change their phenotype into osteoblast-like cells via the loss of smooth muscle markers (e.g., α-smooth muscle ...
Hi Everyone, I have an ulcer on my right hand, index finger on knuckle which has lead to a calcinosis, (same finger), which has become abscessed on pad, its becoming bigger. I went to see my internist today which I had scheduled to see her a couple months ago. She prescribed an antibiotic hoping ...
calcinosis from radiesse. Scleroderma - Dermatologist in Honolulu, HI. You can give yourself fuller lips instantly with the Lip Plumper. Give yourself fuller lips instantly as Idol Lips
The Coronary Artery Calcium Scoring CT Scan can detect and measure the extent of the calcium deposits in the coronary arteries. This may help determine a diagnosis of heart disease early.
This review focuses on the functions of NPP1 in the regulation of physiologic and pathologic calcification, principally via PPi generation from nucleoside triphosphates in tissues (and cells) including cartilage (and chondrocytes), bone (and osteoblasts), and large arteries (and smooth muscle cells (SMCs)). ...
OBJECTIVES: Recently, the density score of coronary artery calcium (CAC) has been shown to be associated with a lower risk of cardiovascular disease (CVD) events at any level of CAC volume. Whether risk factors for CAC volume and CAC density are similar or distinct is unknown. We sought to evaluate the associations of CVD risk factors with CAC volume and CAC density scores. METHODS: Baseline measurements from 6814 participants free of clinical CVD were collected for the Multi-Ethnic Study of Atherosclerosis. Participants with detectable CAC (n=3398) were evaluated for this study. Multivariable linear regression models were used to evaluate independent associations of CVD risk factors with CAC volume and CAC density scores. RESULTS: Whereas most CVD risk factors were associated with higher CAC volume scores, many risk factors were associated with lower CAC density scores. For example, diabetes was associated with a higher natural logarithm (ln) transformed CAC volume score (standardised ß=0.44 ...
Palma, Spain and San Diego, USA, August 6, 2018 - Laboratoris Sanifit S.L., a clinical-stage biopharmaceutical company focused on treatments for calcification disorders, today announced the completion of enrollment of its Phase 2b CaLIPSO clinical trial investigating Sanifit’s lead candidate SNF472, for the tr...
Background Subclinical hypothyroidism (SCH) is defined as an isolated elevation of thyroid stimulating hormone (TSH) levels in conjugation with normal circulating levels of free triiodothyronine and free thyroxine. It is a highly prevalent disease especially in the elderly population. Thyroid hormones affect the heart and vasculature by both genomic and nongenomic pathways. However, the impact of SCH on the cardiovascular system is a matter of debate. Researches have been conducted to study the effect of SCH on cardiovascular system, yielding conflicting results. Although some studies support increased risk of cardiovascular events in patients with SCH, others show no significant increased risk. Aim This study was conducted to evaluate if SCH is associated with higher risk of coronary heart diseases in the elderly and if dyslipidemia, endothelial dysfunction as measured by flow-mediated dilatation (FMD) and carotid artery intima-media thickness were associated with SCH. Patients and methods ...
Breast arterial calcifications (BACs) are common findings on mammograms. There are calcium deposits in the media layer of the peripheral arterioles and this condition is called M nckeberg medial
RE was present in 984 (12.0%) participants. RE at baseline was associated with CAC progression (odds ratio [OR], 1.253; 95% confidence interval [CI], 1.088-1.444; P = 0.002), and this association persisted after adjusting the model for age, sex, smoking status, and alcohol consumption (OR, 1.175; 95% CI, 1.001-1.378; P = 0.048). This association disappeared when the model was further adjusted for body mass index, diastolic blood pressure, the presence of hypertension, glycated hemoglobin, low-density lipoprotein cholesterol, and triglycerides (OR, 1.088; 95% CI, 0.924-1.281; P = 0.311) which were selected using a stepwise selection procedure from several metabolic variables.. CONCLUSIONS ...
Read more about Harder calcium deposits may predict heart attack risk on Business Standard. People with proportionately higher quantities of harder calcified plaque best predicted risk of heart attacks, while soft plaque did not, representing a potential paradigm shift, researchers said.
Breast calcifications are calcium deposits within breast tissue. They appear as white spots or flecks on a mammogram and are usually so small that you cant feel them.
Urolithiasis is described as the presence of stones (calcium deposits) in the urinary tract. The development of these stones is more common in dogs than in cats, and in older animals. In most cases the stones can be removed safely, giving the animal a positive prognosis.
The second, more technological way, to determine risk is with an imaging study called a Coronary Calcium Scan. A Coronary Calcium Scan is a non-contrast, low-radiation, CT scan of the heart that takes about 30 seconds to acquire and costs about $50. The heart scan is then reviewed for evidence of calcium within the arteries of the heart; the plaque within the heart arteries calcifies or scars over time and is easily seen on these scans. Using a standardized software, the amount of calcified plaque is scored by an automated process. Coronary calcium scores range from zero (normal) to the low thousands. Because tens of thousands of patients with different scores have been followed for years, we know that a patients coronary calcium score directly correlates to risk over time. These scans are more predictive than risk calculators because they directly look for plaque formation within the artery walls. There is no test in the field of cardiology that can portend a better prognosis for a patient ...
Vascular calcification/aging is common in diabetes and is associated with increased morbidity and mortality of patients. MiR-34c-5p, not miR-34c-3p, was suppressed significantly in calcification/senescence of human aorta vascular smooth muscle cells (HA-VSMCs) induced by high glucose, which was proven by the formation of mineralized nodules and staining of senescence associated-β-galactosidase staining (SA β-gal) positive cells. Overexpression of miR-34c-5p alleviated calcification/senescence of HA-VSMCs, whereas inhibition of miR-34c-5p received the opposite results. Bcl-2 modifying factor (BMF) was a functional target of miR-34c-5p and it was involved in the process of calcification/senescence of HA-VSMCs. Besides, lncRNA-ES3 acted as a competing endogenous RNAs (ceRNA) of miR-34c-5p to enhance BMF expression. Further, lncRNA-ES3 inhibited miR-34c-5p expression by direct interaction and its knockdown suppressed the calcification/senescence of HA-VSMCs. Our results showed for the first time that the
We modeled CAC as a continuous and binary variable (present/absent and zero or ,400). In accordance with prior reports, CAC was analyzed as a continuous variable using base-2 logarithm of coronary calcium score plus 1 (log2 [CAC+1]) to determine how the doubling of calcium score affects risk and to include those with CAC = 0 (20). There were no deviations from the linear assumption when modeling continuous CAC.. Baseline characteristics are presented by CAC stratum. Continuous variables are presented as mean ± SD, whereas categorical variables as the number with the attribute (percentage of total). Analysis of variance was used to test means across groups for normally distributed variables and Kruskal-Wallis for not normally distributed variables. Chi-square analysis was used to test differences in distributions for categorical variables.. The risk of each non-CVD diagnosis was analyzed individually and with a composite measure of the first occurrence of any one of the diagnoses. Raw ...
(HealthDay)-In addition to traditional cardiovascular disease risk factors, in patients with type 2 diabetes, coronary artery calcium (CAC) predicts the risk of cardiovascular death, according to a study published online ...
On this picture we can see a calcified breast artery as a result of a treatment of hypertension. By taking such drug for high blood pressure, a thiazide diuretic, the body retains calcium and releases from potassium and magnesium. These calcification may occur throughout the whole body not just in the breasts, but can also be avoided ...
Role of the radiologist Radiologists who interpret mammograms encounter calcifications on a daily basis (see the images below). Most of the breast calcifications encountered by radiologists are benign.
1-18 Ex. 1-17 & 18 Subgross and conventional histological images of ducts with extensive necrosis and a few remaining cancer cells. 1 continued The presence of fragmented casting type calcifications is a highly reliable radiological sign of malignancy. Preoperative microscopic diagnosis is necessary for optimum patient management. Histological−mammographic correlation helps us understand that the regions containing calcifications with high, even density and smooth contour will have the fewest viable malignant cells. The rectangles outline the cluster of calcifications. Ex. 4-3 Fragmented Casting Type Calcifications 33 Differential Diagnostic Problems Ex. 4-4 Specimen radiograph shows that the malignant type calcifications are distributed over a large area (rectangle). 40 mm 35 mm Ex. 4-4 Ex. 4-5 & 6 Histology: 40 mm × 35 mm Grade 3 solid and micropapillary DCIS with signs of epithelial−stromal interaction (periductal desmoplastic reaction and lymphocytic infiltration). Ex. 4-5 Ex. 4 ...
The contribution of medial calcification to vascular dysfunction in renal failure is unknown. Vascular function was measured ex vivo in control, noncalcified uremic, and calcified uremic aortas from rats with adenine-induced renal failure. Plasma urea was 16 + 4, 93 + 14, and 110 + 25 mg/dl, and aortic calcium was 27 + 4, 29 + 2, and 4946 + 1616 nmol/mg dry weight respectively in the three groups. Maximal contraction by phenylephrine (PE) or KCl was reduced 53 % and 63 % in uremic aortas and sensitivity, EC50 value, to KCl but not PE was increased. Maximal relaxation to acetylcholine was impaired in uremic aortas (30 % vs. 65 %) and sensitivity to nitroprusside was also reduced, indicating some impairment of endothelium-independent relaxation as well. None of these parameters differed between calcified and noncalcified uremic aortas. However, aortic compliance was reduced in calcified aortas, ranging from 17 % to 61 % depending on the severity of calcification. We conclude that uremic vascular ...
BACKGROUND: In patients with dilated (idiopathic) cardiomyopathy (DCM), little is known about the presence of valvular calcification and its association with hypovitaminosis D, which may predispose affected tissues to calcification. Our objectives were 2-fold: to conduct a retrospective assessment of echocardiographic evidence of valvular calcification in patients with DCM who were known to have hypovitaminosis D (25(OH)D ...
A coronary calcium screening is an easy and painless scan that is the only non-invasive way to find whether you have calcium deposits in your heart arteries. Early detection is the key to preventing heart attacks in otherwise healthy people. Learn more
In this video previously posted on Medscape Cardiology, Iftikhar J. Kullo, M.D., Mayo Clinic professor of medicine, and Naveen L. Pereira, M.D., assistant professor of medicine, discuss coronary calci...
The latest predictive tool can help determine your risk of heart disease and whether or not you would benefit from statins as a preventive measure.
Rabbit polyclonal antibody raised against a full-length human ANXA2 protein. ANXA2 (NP_001002858.1, 1 a.a. ~ 357 a.a) full-length human protein. (H00000302-D01P) - Products - Abnova
Mouse polyclonal antibody raised against a full-length human LOC202051 protein. LOC202051 (XP_939065.1, 1 a.a. ~ 188 a.a) full-length human protein. (H00202051-B01P) - Products - Abnova
This is an example of an automated calcium scoring software to speed review of coronary artery calcium (CAC) scoring cardiac computed tomography (CT) scans. This advanced visualization software from Ziosoft uses artificial intelligence to segment the coronary vessels, identify valves and the aorta and then color code tag the calcium deposits and quantify the amount of calcified plaque in each vessel. It tallies the score into a table and computes an overall Agatston risk score. This risk score correlates to that patients risk for a heart attack in the future. The software notes calcium in the heart outside the coronaries in valve leaflets and the aorta, but excludes this data. This type of automation is now offered by most advanced visualization and CT system vendors. This automation can save a large amount of post-processing time and make it easier for hospitals to offer low-cost CAC CT screening programs. CAC scans can be used to determine if a patient needs to go on statin therapy. An ...
This is an example of an automated calcium scoring software to speed review of coronary artery calcium (CAC) scoring cardiac computed tomography (CT) scans. This advanced visualization software from Ziosoft uses artificial intelligence to segment the coronary vessels, identify valves and the aorta and then color code tag the calcium deposits and quantify the amount of calcified plaque in each vessel. It tallies the score into a table and computes an overall Agatston risk score. This risk score correlates to that patients risk for a heart attack in the future. The software notes calcium in the heart outside the coronaries in valve leaflets and the aorta, but excludes this data. This type of automation is now offered by most advanced visualization and CT system vendors. This automation can save a large amount of post-processing time and make it easier for hospitals to offer low-cost CAC CT screening programs. CAC scans can be used to determine if a patient needs to go on statin therapy. An ...
A microscope image of cardiac calcification in a mouse showing cardiac fibroblasts (red) expressing the ENPP1 protein (green and yellow) ...
Summary: The patients work-up included pulmonary function tests, which revealed a reduction in vital capacity and a decreased lung compliance. The results ...
Electron beam tomography (EBT) is a specific kind of CT by which a considerable more than enough X-ray tube is made to ensure only the path in the electrons, travelling concerning the cathode and anode in the X-ray tube, are spun working with deflection coils. This type had A serious edge due to the fact sweep speeds is often much speedier, making it possible for for considerably less blurry imaging of going buildings, like the heart and arteries ...
Calcification involves the building up of calcium deposits in the body tissues, according to HealthGrades. It can cause symptoms such as severe bone pain, headache and pain in the pelvis, lower back...
Get up about the same time every day.. Go to bed only when you are sleepy and get out of bed when you are awake.. Establish pre-sleep rituals, such as a warm bath, a light bedtime snack, brushing teeth, putting on bedtime clothing, or 10 minutes of reading.. Exercise regularly. If you exercise vigorously, do this at least 3 to 6 hours before bedtime. Mild exercise - such as simple stretching or walking - needs to be done 4 hours before bedtime.. Maintain a regular schedule for eating meals, taking medications, and doing chores to help keep your "inner clock" running smoothly.. Avoid anything containing caffeine within 6 hours of bedtime.. Avoid alcohol within several hours of bedtime or when you are sleepy.. Avoid smoking close to bedtime because nicotine is a stimulant.. Avoid falling asleep in front of the television.. If you take naps, try to do so at the same time every day. For most people, a short mid-afternoon nap is most helpful.. Avoid sleeping pills or use them conservatively. Most ...
Total of 1668 arteries in 417 patients (286 men, 131 women) were evaluated, mean age 60,3 ± 8,9 years. Mean total Agatston score was 444,7 (0-4274,6). LM had the lowest quantity of calcium for both genders and LAD had the most. For all arteries combined, computed tomography detected ,70% stenosis with sensitivity of 46,9%, specificity of 93,6% and positive and negative predictive values of 61,7% and 88,8%, respectively. Negative predictive value was 96,0%, 94,7%, 92,2%, 91,3%, 83,3% and 78,2% for groups A, B, C, D, E and F respectively. When evaluating LM, LAD, LCX and RCA computed tomography detected ≥50% senosis with sensitivity and specificity of 40,0% and 94,6%, 84,0% and 50,8%, 46,4% and 82,2% and 74,1% and 81,2% for LM, LAD, LCX and RCA respectively. Accuracy was found lower with higher Agatston score in each artery and was for groups A, B, C, D, E, F, G 96,0%, 92,6%, 94,1%, 68,4% and 60,9% for LM, 74,5%, 84,4%, 71,2%, 63,5%, 57,2%, 68,6% and 58,8% for LAD, 88,5%, 78,2%, 67,6%, 54,3%, ...
After getting a string of terrible doctors, Ive finally found a good one. She thinks its endometriosis and sent me in for an ultrasound (my third in 2 years). Usually the ultrasound finds that everything is normal - just a little free fluid in the vaginal canal. This time the technician said she saw several spots of calcification on my ovaries. She said it was nothing to worry about but my research is leading me to believe thats not necessarily true ...
The compound 13-cis retinoic acid was first studied in the 1960s at Roche Laboratories in Switzerland by Werner Bollag as a treatment for skin cancer. Experiments completed in 1971 showed that the compound was likely to be ineffective for cancer and, surprisingly, that it could be useful to treat acne. However, they also showed that the compound was likely to cause birth defects, so in light of the events around thalidomide, Roche abandoned the product. In 1975, Gary Peck and Frank Yoder independently rediscovered the drug's use as a treatment of cystic acne while studying it as a treatment for lamellar ichthyosis, and published that work. Roche resumed work on the drug. In clinical trials, subjects were carefully screened to avoid including women who were or might become pregnant. Roche's New Drug Application for isotretinoin for the treatment of acne included data showing that the drug caused birth defects in rabbits. The FDA approved the application in 1982. Scientists involved in the ...
"calcinosis_cutis_2_060122". Derm Atlas. Archived from the original on 5 February 2007. Retrieved 13 March 2012.. ...
Enzootic Calcinosis Archived 2014-07-28 at the Wayback Machine. Gruenberg MS, PhD, DECAR DECBHM. W.G., April 2014. Enzootic ... Calcinosis. The Merck Veternary Manual. Merck Sharp & Dohme, Whitehouse Station, NJ, USA. Topical Agents (Toxicity) Archived ...
"Gastric mucosal calcinosis: clinicopathologic considerations". Advances in Anatomic Pathology. 14 (3): 224-8. doi:10.1097/PAP. ... Drowsiness Headache Gastric mucosal calcinosis Heart valve calcification Hypercalcemia Increased intracranial pressure ...
... calcinosis (calcium deposits in blood vessels); atherosclerosis (blockage of blood vessels); type 2 diabetes; loss of bone mass ...
TSC2 Tumoral calcinosis, familial, normophosphatemic; 610455; SAMD9 Tumoral calcinosis, hyperphosphatemic; 211900; KL Tumoral ... calcinosis, hyperphosphatemic, familial; 211900; FGF23 Tumoral calcinosis, hyperphosphatemic, familial; 211900; GALNT3 Tyrosine ...
"calcinosis_cutis_2_060122". Derm Atlas. Retrieved 13 March 2012. "Calcium Pyrophosphate Dihydrate Deposition Disease: Synovial ...
Calcinosis cutis is condition in which there are irregular nodular deposits of calcium salts in skin and subcutaneous tissue. ... Calcinosis Monckeberg's arteriosclerosis "Cell Injury". Bertazzo, Sergio; Gentleman, Eileen; Cloyd, Kristy L.; Chester, Adrian ...
Dystrophic calcinosis cutis has also been reported. Other serious sequelae include sialolithiasis of the submandibular gland ... Oga, A.; Kadowaki, T.; Hamanaka, S.; Sasaki, K. (1998). "Dystrophic calcinosis cutis in the skin below the mandible of a ...
Dereure O (May 2007). "[SAMD9 mutation in normophosphatemic familial tumoral calcinosis]". Annales De Dermatologie Et De ... "A deleterious mutation in SAMD9 causes normophosphatemic familial tumoral calcinosis". American Journal of Human Genetics. 79 ( ...
2007). "Tumoral calcinosis presenting with eyelid calcifications due to novel missense mutations in the glycosyl transferase ... 2006). "Polypeptide GalNAc-transferase T3 and familial tumoral calcinosis. Secretion of fibroblast growth factor 23 requires O- ... cause familial tumoral calcinosis". Nat Genet. 36 (6): 579-81. doi:10.1038/ng1358. PMID 15133511. "Entrez Gene: GALNT3 UDP-N- ... "Two novel nonsense mutations in GALNT3 gene are responsible for familial tumoral calcinosis". J. Hum. Genet. 52 (5): 464-8. doi ...
Calcinosis Fahr's syndrome Muscular atrophy "OMIM Entry - # 259050 - PRIMROSE SYNDROME; PRIMS". omim.org. Retrieved 6 August ...
Kalani, MY; Martirosyan, NL; Little, AS; Kakarla, UK; Theodore, N (Dec 2011). "Tumoral calcinosis presenting as a deformity of ...
Bonazza S, La Morgia C, Martinelli P, Capellari S (August 2011). "Strio-pallido-dentate calcinosis: a diagnostic approach in ... Loeb JA (March 1998). "Functional improvement in a patient with cerebral calcinosis using a bisphosphonate". Mov. Disord. 13 (2 ...
Gorospe M, Fadare O (May 2007). "Gastric mucosal calcinosis: clinicopathologic considerations". Advances in Anatomic Pathology ...
Some children develop calcinosis, which are calcium deposits under the skin. The rash is the source of the "dermato-" part of ... calcinosis and neopterin. Once a diagnosis of JDMS is made, the treatment is often a 3-day course of Intravenous ("pulse") ... calcinosis, dysphonia and nailfold capillaroscopy. Other useful criteria include myositis-specific or -related antibodies, ...
Calcinosis cutis Skin lesion List of cutaneous conditions James, William D.; Berger, Timothy G.; et al. (2006). Andrews' ...
It is a part of CREST syndrome, referring to the five main features: calcinosis, Raynaud syndrome, esophageal dysmotility, ... Winterbauer RH (1964). "Multiple telangiectasia, Raynaud's phenomenon, sclerodactyly, and subcutaneous calcinosis: a syndrome ...
2000). Enzootic calcinosis in 16 cows from 6 dairy farms in Unterengadin. Schweiz Arch Tierheilkd. 142:6 333-8. Braun, U., et ... 2000). Enzootic calcinosis in goats caused by golden oat grass (Trisetum flavescens). Veterinary Record 146 161-2. Grabner, A ... 1985). Enzootic calcinosis in the horse. Tierarztl Prax Suppl. 1 84-93. Ess. Agrostogr. 88, 153. 1812 GrassBase entry: Trisetum ... This grass is noted for being toxic to livestock, causing calcinosis, the deposition of calcium in soft tissues including ...
Lesions may also appear on the ear and eyelid.[citation needed] Calcinosis cutis Skin lesion List of cutaneous conditions ... Subepidermal calcified nodule (also known as a "solitary congenital nodular calcification", and "Winer's nodular calcinosis") ...
Other: facial pain due to trigeminal neuralgia, hand paresthesias, headache, stroke, fatigue, calcinosis and weight loss. ...
CREST causes thickening and tightening of the skin with deposition of calcific nodules ("calcinosis"). Raynaud's phenomenon is ... The acronym "CREST" refers to the five main features: calcinosis, Raynaud's phenomenon, esophageal dysmotility, sclerodactyly, ... Scleroderma Winterbauer RH (1964). "Multiple telangiectasia, Raynaud's phenomenon, sclerodactyly, and subcutanious calcinosis: ...
Typical clinical features include jaundice, elevated blood levels of alkaline phosphatase, calcinosis cutis, telangiectasias, ...
... renal insufficiency and calcinosis. Calcium forms complexes with a number of pharmaceutical drugs, reducing their ...
Loss of FGF23 activity is thought to lead to increased phosphate levels and the clinical syndrome of familial tumor calcinosis ...
Based upon the etiology of calcium deposition, there are five subtypes of calcinosis cutis: dystrophic, metastatic, idiopat ... Calcinosis cutis is a descriptive term for the deposition of insoluble calcium salts in the cutaneous and subcutaneous tissue. ... Idiopathic calcinosis cutis: Idiopathic calcinosis cutis is the occurrence of calcinosis cutis without any underlying tissue ... Iatrogenic calcinosis cutis: Iatrogenic calcinosis cutis is the deposition of calcium salts in the skin as a side effect of ...
Calcinosis is the formation of calcium deposits in any soft tissue. The most common type of calcinosis is dystrophic ... The cause of the rare condition of tumoral calcinosis is not entirely understood. It is generally characterized by large, ... Calcinosis cutis Dermatomyositis Fahrs syndrome Hypercalcemia Hyperphosphatemia Primrose syndrome Scleroderma Univ. Washington ...
Tumoral calcinosis is a rare condition in which there is calcium deposition in the soft tissue in periarticular location i.e. ... The name indicates calcinosis (calcium deposition) which resembles tumor (like a new growth). They are not true neoplasms - ... Genetests/NCBI/NIH/UW entries on Hyperphosphatemic Familial Tumoral Calcinosis. ...
... calcinosis cutis Metastatic calcinosis cutis Iatrogenic calcinosis cutis Traumatic calcinosis cutis Idiopathic calcinosis cutis ... Calcinosis cutis in a dog with Cushings syndrome Calcinosis cutis in human tissue Calcinosis List of cutaneous conditions ... Calcinosis cutis (or cutaneous calcification) is a type of calcinosis wherein calcium deposits form in the skin. A variety of ... calcinosis cutis is found in young, large breed dogs and is thought to occur after a traumatic injury. Calcinosis may result ...
... By Stephanie Eschenbach, MD and Thomas L. Pope, Jr., MD, FACR ... 2 Subcutaneous calcinosis, as part of the CREST variant or diffuse variant, is often seen on the extensor surfaces and in areas ... subcutaneous calcinosis on the left thumb volar pad; 5) moderate-to-severe resorption of the right first-, second-, and third- ... "7 The combination of calcinosis and acro-osteolysis, as seen in Figure 2, is considered to be pathognomic for scleroderma.6 ...
Calcinosis cutis List of cutaneous conditions James, William D.; Berger, Timothy G.; et al. (2006). Andrews Diseases of the ... Dystrophic calcinosis cutis is a cutaneous condition characterized by calcification of the skin resulting from the deposition ...
Milia-like calcinosis is a cutaneous condition characterized by small, milia-like lesions that develop on the dorsal surface of ...
Scrotal calcinosis was first described in 1883 by Lewinski. Calcinosis cutis Skin lesion List of cutaneous conditions Rapini, ... The scrotal calcinosis appears, without any symptoms, as yellowish nodules that range in size from 1 mm to several centimeters ... Idiopathic scrotal calcinosis (also known as idiopathic calcified nodules of the scrotum) is a cutaneous condition ... Idiopathic scrotal calcinosis typically affects young males, with an onset between adolescence and early adulthood. ...
We present what we believe is the first identified case of autoimmune hyperphosphatemic tumoral calcinosis in an 8-year-old boy ... Hyperphosphatemic familial tumoral calcinosis (HFTC)/hyperostosis-hyperphosphatemia syndrome (HHS) is an autosomal recessive ... In addition to the classical clinical and biochemical features of hyperphosphatemic tumoral calcinosis, the patient exhibited ... Thus, this report describes the first case, to our knowledge, of autoimmune hyperphosphatemic tumoral calcinosis with ...
Evaluation of Calcinosis Prevalence in Systemic Sclerosis : a Cross Sectional Study Evaluating Calcinosis Cutis Prevalence by ... Evaluation of Calcinosis in Systemic Sclerosis (CALCIDERMIS). The safety and scientific validity of this study is the ... Calcinosis cutis prevalence by radiographic assessment [ Time Frame: at inclusion ( baseline) ]. Secondary Outcome Measures : * ... Calcinosis. Pathologic Processes. Connective Tissue Diseases. Skin Diseases. Calcium Metabolism Disorders. Metabolic Diseases. ...
Bilateral striopallidodentate calcinosis. Disease definition Bilateral striopallidodentate calcinosis (BSPDC, also erroneously ...
JavaScript is disabled for your browser. Some features of this site may not work without it ...
... primary hyperphosphatemic tumoral calcinosis; tumoral calcinosis with hyperphosphatemia ... Synonyms: cortical hyperostosis with hyperphosphatemia; familial hyperphosphatemic tumoral calcinosis/hyperphosphatemic ... hyperostosis syndrome; familial Teutschlaender disease; HFTC; HHS; hypercalcemic tumoral calcinosis; hyperostosis with ... tumoral calcinosis with hyperphosphatemia Alt IDs: OMIM:211900, ICD10CM:M11.2, ORDO:306661 Definition: A calcinosis ...
Normophosphatemic familial tumoral calcinosis is a cutaneous disorder characterized by cutaneous calcification or ossification ...
V. Mehta and C. Balachandran, "Idiopathic vulvar calcinosis: the counterpart of idiopathic scrotal calcinosis," Indian Journal ... Scrotal Calcinosis: A Case Report and Review of Pathogenesis and Surgical Management. Usman M. Tela1 and M. Bashir Ibrahim2 ... S. G. Browne, "Calcinosis circumscripta of the scrotal wall, the aetiologic role of onchocerca vulvulus," British Journal of ... C. H. Chang, C. H. Yang, and H. S. Hong, "Surgical pearl: pinch-punch excisions for scrotal calcinosis," Journal of the ...
... calcinosis) on a dime. The calcinosis was removed from a patient who has had systemic sclerosis (scleroderma) for a year. ISN ... Also see Photo of Calcinosis on Fingertip). A year and a half ago, her doctor stopped her Raynauds medication for emotional ... Photo of Calcinosis on Dime. Author: Shelley Ensz. Scleroderma is highly variable. See Types of Scleroderma. Read Disclaimer ... The calcium nodule (calcinosis) is an ugly thing, with lots of irregularities to hang onto flesh. My wife has had scleroderma ...
The Mammalian Phenotype (MP) Ontology is a community effort to provide standard terms for annotating phenotypic data. You can use this browser to view terms, definitions, and term relationships in a hierarchical display. Links to summary annotated phenotype data at MGI are provided in Term Detail reports.
Calcinosis circumscripta is deposition of calcium at bony prominences or, in the footpads and mouth. It is usually a disease of ... Calcinosis cutis is induced by local skin damage in susceptible animals and takes two forms: dystrophic or metastatic. The ... How does calcinosis cutis and calcinosis circumscripta typically progress?. In the case of calcinosis circumscripta, single ... Calcinosis cutis occurs in susceptible pets in areas where local skin damage has occurred. Calcinosis cutis has two forms:. * ...
CALCINOSIS TREATED BY PARATHYROIDECTOMY1 ELMER C. BARTELS, M.D., F.A.C.P.; RICHARD B. CATTELL, M.D. ... CALCINOSIS AND SCLERODERMA WITH PARATHYROIDECTOMY1 Annals of Internal Medicine; 18 (2): 225-232 ... Subcutaneous calcinosis, a disease tending to serious bodily disability, presents a most difficult therapeutic problem. It is ... Dystrophic calcinosis in a patient with overlap syndrome (scleroderma and rheumatoid arthritis) treated by leflunomide: A case ...
... Subscriber Sign In VisualDx Mobile Feedback Select Language Share Get VisualDx Mobile. There are VisualDx ... L94.2 - Calcinosis cutis. SNOMEDCT:. 21323007 - Calcinosis cutis. Look For. Subscription Required. Diagnostic Pearls. ... Calcinosis cutis in Infant/Neonate. Print Images (7) Contributors: Noah Craft MD, PhD, Belinda Tan MD, PhD, Lowell A. Goldsmith ... Note, however, that calcinosis cutis can occur anywhere on the body. Local trauma, infections (particularly parasitic, eg, ...
... index finger on knuckle which has lead to a calcinosis, (same finger), which has become abscessed on pad, its becoming bigger. ... Not sure what hurts more the ulcer or the calcinosis! :wacko: Well..... even if I slightly bump the calcinosis, or touch it, it ... Ulcer and Calcinosis By Annie20, June 8, 2011. in Sclero Forums (MAIN) ... If I bump or press on the calcinosis, it hurts tremendously. (It has become bigger.) I do not want to subject myself to anymore ...
Pronounced Linear Calcinosis in a Boy with Mild Dermatomyositis del Carmen Boente, María; Nadra, Graciela; Asial, Raúl et al. ... Calcinosis in Ruminants due to Plant Poisoning: Contributions on the Pathogenesis Acamovic, T.; Stewart, C. S.; Pennycott, T. ... Tumoral Calcinosis and Calciphylaxis After Renal Transplantation Fernandez, E.; Torregrosa, J. V.; Zarraga, S. et al. 1998-01- ... Tumoral Calcinosis Associated With End-Stage Renal Disease: A Case Study Capes, M.; Fox, R. B.; Association of Chiropractic ...
... defined as calcinosis involving the torso or 2 extremities) and moderate to severe calcinosis (indicated by a calcinosis ... Calcinosis can be painful and cause disabilities and other problems. Researchers want to learn more about calcinosis to find ... Has moderate to severe calcinosis, defined as having a calcinosis activity visual analogue scale score of greater than or equal ... Improvement of calcinosis lesions, assessed by Calcinosis Assessment Tool, durometry measurements, photography, and imaging ...
Calcium and Phosphate Metabolism in Tumoral Calcinosis PAUL D. MITNICK, M.D.; STANLEY GOLDFARB, M.D.; EDUARDO SLATOPOLSKY, M.D ... Calcium and Phosphate Metabolism in Tumoral Calcinosis. Ann Intern Med. 1980;92:482-487. doi: 10.7326/0003-4819-92-4-482 ... We have recently seen a patient with tumoral calcinosis, a syndrome comprising hyperphosphatemia, normocalcemia, normal ...
Treating calcinosis cutis via a topical wash with DMSO every other day was effective for the symptoms of calcinosis cutis. ... A dog with calcinosis cutis was treated by topical dimethyl sulfoxide (DMSO) administration, reaching a complete involution of ... For this reason, DMSO is proposed as a topical treatment for the management of calcinosis cutis in dogs. The authors present ... Resolution of iatrogenic calcinosis cutis in a dog through topical application of DMSO. 26 Sep 2018 ...
  • People ages 7 and older who have moderate or severe calcinosis. (clinicaltrials.gov)
  • We report the favorable outcome of rituximab on severe calcinosis in 4 JDM patients and present their clinical data. (scirp.org)
  • Patients and Methods: A retrospective chart review of 4 children with JDM and severe calcinosis who received rituximab for relapsing or polycyclic JDM course. (scirp.org)
  • Conclusion: Our study showed the favorable effect of rituximab in treatment of calcinosis in 4 patients with JDM-associated severe calcinosis when it was used with other conventional DMARDs. (scirp.org)
  • We report a case of severe calcinosis in a 14-year-old girl who was treated with thalidomide, a treatment encouraged by the partial effectiveness of etanercept, a soluble TNF receptor fusion protein. (biomedcentral.com)
  • In addition to the classical clinical and biochemical features of hyperphosphatemic tumoral calcinosis, the patient exhibited markedly elevated intact and C-terminal FGF23 levels, suggestive of FGF23 resistance. (jci.org)
  • The authors present the clinical case of a dog with seropositive leishmaniosis and secondary immune-mediated haemolytic anaemia who was affected by intense dermatopathia on the dorsal area, diagnosed by a biopsy as calcinosis cutis. (bva.co.uk)
  • Pathology department's opinion was that the mucosal calcinosis observed in the corpus mucosa could be associated with calcium dysregulation and could also be secondary to medication, and recommended analyzing correlation with clinical findings. (heighpubs.org)
  • McGuinness FE: Hyperphosphataemic tumoral calcinosis in Bedouin Arabs--clinical and radiological features. (statdx.com)
  • Noyez JF et al: Tumoral calcinosis, a clinical report of eleven cases. (statdx.com)
  • Clinical presentation and radiographs of patient with tumoral calcinosis. (jci.org)
  • This specificity may identify a further immunogenetic and clinical phenotype within the juvenile myositis spectrum that includes an association with calcinosis. (cdc.gov)
  • A calcinosis characterized by autosomal recessive inheritance of elevated blood calcium levels and calcium phosphate crystals in cutaneous and subcutaneous tissues that has_material_basis_in mutation in the GALNT3 gene, the FGF23 gene, or the KL gene. (jax.org)
  • McGregor DH et al: Nonfamilial tumoral calcinosis associated with chronic renal failure and secondary hyperparathyroidism: report of two cases with clinicopathological, immunohistochemical, and electron microscopic findings. (statdx.com)
  • Medical therapy has very limited role in the treatment of calcinosis cutis but drugs like corticosteroids, probenecid, colchicine, sodium etidronate, diphosphonates, diltiazem, and magnesium and aluminium antacids can be used in order to relieve the symptoms9,10. (thefreedictionary.com)
  • This was considered to be consistent with Tumoral Calcinosis in the setting of long-standing renal disease. (thefreedictionary.com)
  • All patients had improvement in disease activity and frequency of admission especially due to complications of calcinosis. (scirp.org)
  • Issa El Khoury F et al: Tumoral calcinosis of the cervical spine and its association with Caffey disease in a 4-month-old boy: case report and review of the literature. (statdx.com)
  • TITLE: "Disappearance of diffuse calcinosis following autologous stem cell transplantation in a child with autoimmune disease" (Elhasid R., et al. (macquariestemcells.com)
  • ABSTRACT: Background: Calcinosis is an important sequela of JDM which may cause significant morbidity and mortality. (scirp.org)