Pathologic deposition of calcium salts in tissues.
A mild form of LIMITED SCLERODERMA, a multi-system disorder. Its features include symptoms of CALCINOSIS; RAYNAUD DISEASE; ESOPHAGEAL MOTILITY DISORDERS; sclerodactyly, and TELANGIECTASIS. When the defect in esophageal function is not prominent, it is known as CRST syndrome.
Diseases of the skin associated with underlying metabolic disorders.
A subacute or chronic inflammatory disease of muscle and skin, marked by proximal muscle weakness and a characteristic skin rash. The illness occurs with approximately equal frequency in children and adults. The skin lesions usually take the form of a purplish rash (or less often an exfoliative dermatitis) involving the nose, cheeks, forehead, upper trunk, and arms. The disease is associated with a complement mediated intramuscular microangiopathy, leading to loss of capillaries, muscle ischemia, muscle-fiber necrosis, and perifascicular atrophy. The childhood form of this disease tends to evolve into a systemic vasculitis. Dermatomyositis may occur in association with malignant neoplasms. (From Adams et al., Principles of Neurology, 6th ed, pp1405-6)
A condition of abnormally high level of PHOSPHATES in the blood, usually significantly above the normal range of 0.84-1.58 mmol per liter of serum.
Enzymes that catalyze the transfer of N-acetylgalactosamine from a nucleoside diphosphate N-acetylgalactosamine to an acceptor molecule which is frequently another carbohydrate. EC 2.4.1.-.
A chronic multi-system disorder of CONNECTIVE TISSUE. It is characterized by SCLEROSIS in the SKIN, the LUNGS, the HEART, the GASTROINTESTINAL TRACT, the KIDNEYS, and the MUSCULOSKELETAL SYSTEM. Other important features include diseased small BLOOD VESSELS and AUTOANTIBODIES. The disorder is named for its most prominent feature (hard skin), and classified into subsets by the extent of skin thickening: LIMITED SCLERODERMA and DIFFUSE SCLERODERMA.
Condition of induced systemic hypersensitivity in which tissues respond to appropriate challenging agents with a sudden local calcification.
Anatomical and functional disorders affecting the foot.
Permanent dilation of preexisting blood vessels (CAPILLARIES; ARTERIOLES; VENULES) creating small focal red lesions, most commonly in the skin or mucous membranes. It is characterized by the prominence of skin blood vessels, such as vascular spiders.
A disease of young infants characterized by soft tissue swellings over the affected bones, fever, and irritability, and marked by periods of remission and exacerbation. (Dorland, 27th ed)
The calcium salt of gluconic acid. The compound has a variety of uses, including its use as a calcium replenisher in hypocalcemic states.
A heparin fraction with a mean molecular weight of 4500 daltons. It is isolated from porcine mucosal heparin and used as an antithrombotic agent. (From Merck Index, 11th ed)
An inorganic pyrophosphate which affects calcium metabolism in mammals. Abnormalities in its metabolism occur in some human diseases, notably HYPOPHOSPHATASIA and pseudogout (CHONDROCALCINOSIS).
A condition characterized by calcification of the renal tissue itself. It is usually seen in distal RENAL TUBULAR ACIDOSIS with calcium deposition in the DISTAL KIDNEY TUBULES and the surrounding interstitium. Nephrocalcinosis causes RENAL INSUFFICIENCY.
The mineral component of bones and teeth; it has been used therapeutically as a prosthetic aid and in the prevention and treatment of osteoporosis.
A fetuin subtype that is synthesized by HEPATOCYTES and secreted into the circulation. It plays a major role in preventing CALCIUM precipitation in the BLOOD.
Diseases of the BASAL GANGLIA including the PUTAMEN; GLOBUS PALLIDUS; claustrum; AMYGDALA; and CAUDATE NUCLEUS. DYSKINESIAS (most notably involuntary movements and alterations of the rate of movement) represent the primary clinical manifestations of these disorders. Common etiologies include CEREBROVASCULAR DISORDERS; NEURODEGENERATIVE DISEASES; and CRANIOCEREBRAL TRAUMA.
Inorganic salts of phosphoric acid.
Drugs used to treat or prevent skin disorders or for the routine care of skin.
An idiopathic vascular disorder characterized by bilateral Raynaud phenomenon, the abrupt onset of digital paleness or CYANOSIS in response to cold exposure or stress.
A family of small polypeptide growth factors that share several common features including a strong affinity for HEPARIN, and a central barrel-shaped core region of 140 amino acids that is highly homologous between family members. Although originally studied as proteins that stimulate the growth of fibroblasts this distinction is no longer a requirement for membership in the fibroblast growth factor family.
A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classified according to their predominant pathophysiological features (DILATED CARDIOMYOPATHY; HYPERTROPHIC CARDIOMYOPATHY; RESTRICTIVE CARDIOMYOPATHY) or their etiological/pathological factors (CARDIOMYOPATHY, ALCOHOLIC; ENDOCARDIAL FIBROELASTOSIS).
Autoantibodies directed against various nuclear antigens including DNA, RNA, histones, acidic nuclear proteins, or complexes of these molecular elements. Antinuclear antibodies are found in systemic autoimmune diseases including systemic lupus erythematosus, Sjogren's syndrome, scleroderma, polymyositis, and mixed connective tissue disease.
A non-metal element that has the atomic symbol P, atomic number 15, and atomic weight 31. It is an essential element that takes part in a broad variety of biochemical reactions.
The clear constricted portion of the chromosome at which the chromatids are joined and by which the chromosome is attached to the spindle during cell division.
A negatively-charged extracellular matrix protein that plays a role in the regulation of BONE metabolism and a variety of other biological functions. Cell signaling by osteopontin may occur through a cell adhesion sequence that recognizes INTEGRIN ALPHA-V BETA-3.
Four or five slender jointed digits in humans and primates, attached to each HAND.
Antibodies that react with self-antigens (AUTOANTIGENS) of the organism that produced them.
The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.
Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.
A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.
The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION.
A group of connective tissue diseases in which skin hangs in loose pendulous folds. It is believed to be associated with decreased elastic tissue formation as well as an abnormality in elastin formation. Cutis laxa is usually a genetic disease, but acquired cases have been reported. (From Dorland, 27th ed)
A bile salt formed in the liver by conjugation of deoxycholate with glycine, usually as the sodium salt. It acts as a detergent to solubilize fats for absorption and is itself absorbed. It is used as a cholagogue and choleretic.
The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.
A surgical specialty concerned with the study, diagnosis, and treatment of diseases of the urinary tract in both sexes, and the genital tract in the male. Common urological problems include urinary obstruction, URINARY INCONTINENCE, infections, and UROGENITAL NEOPLASMS.
Lower urinary tract symptom, such as slow urinary stream, associated with PROSTATIC HYPERPLASIA in older men.
Increase in constituent cells in the PROSTATE, leading to enlargement of the organ (hypertrophy) and adverse impact on the lower urinary tract function. This can be caused by increased rate of cell proliferation, reduced rate of cell death, or both.
Books in the field of medicine intended primarily for consultation.
Symptoms of disorders of the lower urinary tract including frequency, NOCTURIA; urgency, incomplete voiding, and URINARY INCONTINENCE. They are often associated with OVERACTIVE BLADDER; URINARY INCOMPETENCE; and INTERSTITIAL CYSTITIS. Lower urinary tract symptoms in males were traditionally called PROSTATISM.
Abnormalities in the process of URINE voiding, including bladder control, frequency of URINATION, as well as the volume and composition of URINE.
The capability of the LUNGS to distend under pressure as measured by pulmonary volume change per unit pressure change. While not a complete description of the pressure-volume properties of the lung, it is nevertheless useful in practice as a measure of the comparative stiffness of the lung. (From Best & Taylor's Physiological Basis of Medical Practice, 12th ed, p562)
A term used to describe a variety of localized asymmetrical SKIN thickening that is similar to those of SYSTEMIC SCLERODERMA but without the disease features in the multiple internal organs and BLOOD VESSELS. Lesions may be characterized as patches or plaques (morphea), bands (linear), or nodules.
Measurement of the various processes involved in the act of respiration: inspiration, expiration, oxygen and carbon dioxide exchange, lung volume and compliance, etc.
The volume of air that is exhaled by a maximal expiration following a maximal inspiration.

Broncholithiasis: rare but still present. (1/3283)

Broncholithiasis is a rare but distinct and potentially dangerous pulmonary problem that still needs to be considered in the differential diagnosis of some patients with bronchial obstruction. Broncholiths originate from calcified material in peribronchial lymph nodes eroding into the tracheobronchial tree. The clinical and chest X-ray signs are usually non-specific, but the diagnosis can nowadays be made based on clinical suspicion, CT-scan and fibre-optic bronchoscopy findings, so that a malignant cause of airway obstruction can be ruled out. The removal of broncholiths during fibre-optic bronchoscopy is seldom possible and rather dangerous. They can be removed safely by rigid bronchoscopy with the aid of Nd-YAG laser photocoagulation. Thoracotomy is indicated in complicated cases with fistula formation or severe bleeding.  (+info)

Role of glutaraldehyde in calcification of porcine aortic valve fibroblasts. (2/3283)

Glutaraldehyde-treated porcine aortic valve xenografts frequently fail due to calcification. Calcification in the prostheses begins intracellularly. In a previous study, various types of cell injury to canine valvular fibroblasts, including glutaraldehyde treatment, led to calcification. An influx of extracellular Ca2+ into the phosphate-rich cytosol was theorized to be the mechanism of calcification. To test the Ca2+ influx theory, cytosolic Ca2+ and Pi concentrations were assessed in glutaraldehyde-treated porcine aortic valve fibroblasts, and their relationship to a subsequent calcification was studied. Glutaraldehyde caused an immediate and sustained massive cytosolic Ca2+ increase that was dose dependent and a several-fold increase in Pi. Calcification of cells followed within a week. The earliest calcification was observed in blebs formed on glutaraldehyde-treated cells. Live control cells or cells fixed with glutaraldehyde in Ca2+-free solution did not calcify under the same conditions. Concomitant increases in Ca2+ and Pi in glutaraldehyde-treated cells appear to underlie the mechanism of calcification, and the presence of extracellular Ca2+ during glutaraldehyde fixation promotes calcification.  (+info)

Histology and tissue chemistry of tidemark separation in hamsters. (3/3283)

Adult articular cartilage is divided by the tidemark into a deep calcified layer and a more superficial uncalcified layer. Histologic examination of articular cartilage from the knee joint of golden Syrian hamsters 123 days of age or older revealed defects at the tidemark in the tibia. Defects ranged from small separations of the calcified and uncalcified layers along the tidemark to progressively larger defects apparently formed by dissolution. These larger defects appeared as cavities in the noncalcified cartilage, had smooth rather than rough edges, frequently contained coalesced debris, and often resulted in a bulge in the articular surface. Occasionally, these large defects broke through the articular surface. Defects were not observed in tibial cartilage of younger (<90 days old) hamsters or in femoral cartilage from hamsters of any age. Exercise neither protected against nor increased the severity of the defects. Collagen cross-linking by pyridinoline was examined as a function of age and increased from 1,090 to 3,062 micromoles of pyridinoline/mole of hydroxyproline over the period of 1-9 months of age but was not correlated with defect formation. With increasing age, these focal tidemark defects could lead to osteoarthrosis-like cartilage lesions.  (+info)

Incidence and clinical relevance of coronary calcification detected by electron beam computed tomography in heart transplant recipients. (4/3283)

BACKGROUND: Patients treated by cardiac transplantation who survive beyond one year are at significant risk from fatal coronary artery disease. The development of coronary artery calcification in these patients is discussed and methods available to detect it are reviewed. OBJECTIVES: To assess the clinical importance of coronary artery calcium in heart transplant recipients. METHODS: In a cohort of 102 cardiac transplant recipients, electron beam computed tomography was used to measure calcium in the coronary arterial wall 63 days to 9.1 years (median 4.6 years) after transplantation. The results were compared with angiographic findings and with conventional coronary disease risk factors. The patients were followed for a mean of 2.12 years (1.2-4.02 years) to assess the relationship between these findings and future cardiac events. RESULTS: Forty-one (40.2%) had a stenosis of > 24% in one or more major coronary artery at angiography. Forty-six (45%) had a coronary calcium score > 0. The absence of calcium had a negative predictive value with respect to angiographic disease in any vessels of 87.5%. Logistic regression revealed that dyslipidaemia, systemic hypertension and organ ischaemic time were significant predictors of calcification. At follow-up, both an abnormal coronary angiogram and coronary calcium were found to be the only significant predictors of late events. Multivariate analysis suggested that the detection of coronary calcium did not offer any additional predictive information over that provided by the angiogram itself. CONCLUSION: Electron beam computed tomography is well suited to the assessment of calcium in the coronary arteries of heart transplant recipients, although the mechanisms of this calcification remain poorly understood. Calcium is detected more frequently than would be suggested by studies using intravascular ultrasound. It is associated with the presence of angiographic disease, and with some conventional risk factors for coronary disease. At follow-up the presence of coronary calcium was associated with an adverse clinical outcome, as it is in conventional ischaemic heart disease.  (+info)

Renal biopsy in the milk-alkali syndrome. (5/3283)

In milk-alkali syndrome the degree of renal impairment varies greatly. Few reports have been published describing structural changes on renal biopsy. In three illustrative cases, impairment of renal function was related to morphological changes shown on percutaneous biopsy. Milk-alkali syndrome should be considered as a cause of renal dysfunction in patients with a long history of dyspensia.  (+info)

Degenerative changes in aortic root allografts placed in the right ventricular outflow tract of growing puppies. (6/3283)

Differently prepared aortic root allografts were implanted in the right ventricular outflow tract of growing puppies to determine the site of origin and progress of degenerative changes in these conduits. The three preparations assessed were as follows: group A, fresh and sterile grafts; group B, antibiotic sterilized grafts in nutrient medium; and group C, beta-propiolactone sterilized grafts. Although calcification of the aortic wall occurred in all groups, the aortic leaflets were minimally affected. A correlation between viability and lack of calcification and between viability and long-term function is emphasized.  (+info)

Calcific myonecrosis. (7/3283)

Calcific myonecrosis is a rare and late sequela of compartment syndrome, which becomes symptomatic years after the initial trauma. We diagnosed this condition in a 64-year old man, 42 years after he sustained a shot-gun wound to the right lower leg. Total excision of a peripherally calcified, cystic mass, continuous with the anterior tibial muscle belly resulted in complete resolution of symptoms. Consideration of the diagnosis is warranted in patients with a history of major injury who develop a soft tissue mass in the traumatized compartment. The treatment of choice is marginal excision.  (+info)

Angiographic correlation of CT calcification in the carotid siphon. (8/3283)

BACKGROUND AND PURPOSE: Calcification in the coronary arteries has been correlated with significant vessel stenosis. The predictive value of calcification within the carotid siphon has not been characterized; however, stenosis in the carotid siphon is potentially important in determining management of patients with ipsilateral carotid bifurcation stenosis. The purpose of this study was to determine optimal parameters for assessing carotid siphon calcification on head CT scans and to compare the CT findings with angiographic results. METHODS: We performed a retrospective review of patients referred for diagnostic carotid arteriography. Those patients who also had undergone a head CT study at our institution were selected. The CT scans and angiograms of 64 patients (128 vessels) were reviewed. Carotid siphon calcification on CT scans was characterized on brain and bone windows as mild, moderate, or severe. Comparison was then made with angiographic findings. RESULTS: The sensitivity and specificity of CT for depicting greater than 50% angiographic stenosis in the carotid siphon were 86% and 98%, respectively, for bone windows and 100% and 0%, respectively, for brain windows. The positive predictive value (PPV) for a stenosis of greater than 50% as evidenced by severe calcification was 86% on bone windows and 11% on brain windows. The PPV for mild and moderate calcification on bone windows was 2.5% and 0%, respectively. CONCLUSION: Severe CT calcification in the carotid siphon as characterized on bone windows correlates with a carotid siphon stenosis of greater than 50% as determined angiographically. Therefore, the identification of severe calcification offers a potential noninvasive method for identifying stenosis of the carotid siphon. This information may be essential in determining management and prognosis for patients with carotid bifurcation stenosis.  (+info)

Dystrophic calcification (DC) is the calcification occurring in degenerated or necrotic tissue, as in hyalinized scars, degenerated foci in leiomyomas, and caseous nodules. This occurs as a reaction to tissue damage, including as a consequence of medical device implantation. Dystrophic calcification can occur even if the amount of calcium in the blood is not elevated. (A systemic mineral imbalance would elevate calcium levels in the blood and all tissues and cause metastatic calcification.) Basophilic calcium salt deposits aggregate, first in the mitochondria, and progressively throughout the cell. These calcifications are an indication of previous microscopic cell injury. It occurs in areas of cell necrosis in which activated phosphatases bind calcium ions to phospholipids in the membrane. Calcification can occur in dead or degenerated tissue. Caseous necrosis in T.B. is most common site of dystrophic calcification. Liquefactive necrosis in chronic abscesses may get calcified. Fat necrosis ...
Synonyms for dystrophic calcification in Free Thesaurus. Antonyms for dystrophic calcification. 8 words related to calcification: chemical action, chemical change, chemical process, ossification, hardening, inaction, inactiveness, inactivity. What are synonyms for dystrophic calcification?
Background Dystrophic calcifications may occur in patients with J uvenile Idiopathic Inflammatory Myopathy (JIIM) as well as other connective tissue and metabolic diseases, but a reliable method of measuring the volume of these calcifications has not been established. Myositis Assessment Scale (CMAS), myositis specific antibodies (MSA), and the TNF-308 promoter region A/G polymorphism. Statistical analysis utilized the Pearson correlation coefficient, the paired t-test and descriptive statistics. Results Ten JIIM, mean age 14.54??4.54?years, had a duration of untreated disease of 8.68??5.65 months? MSA status: U1RNP (1), PM-Scl (1), Ro (1, 4 indeterminate), p155/140 (2), MJ (3), Mi-2 indeterminate (1), negative (3). 4/8 JDM (50%) were TNF-308 A+. Overall, the calcification volumes tended to decrease from the first to the second CT study by 0.5?cm3 (from 2.79??1.98?cm3 to 2.29??2.25?cm3). The average effective radiation dose was 0.007??0.002, 0.010??0.005, and 0.245?mSv for the upper extremity, ...
TY - JOUR. T1 - Targeting of the osteoclastogenic RANKL-RANK axis prevents osteoporotic bone loss and soft tissue calcification in coxsackievirus B3-infected mice. AU - Lee, Kyunghee. AU - Kim, Hyunsoo. AU - Park, Ho Sun. AU - Kim, Keuk Jun. AU - Song, Hoogeun. AU - Shin, Hong In. AU - Kim, Han Sung. AU - Seo, Donghyun. AU - Kook, Hyun. AU - Ko, Jeong Hyeon. AU - Jeong, Daewon. PY - 2013/2/15. Y1 - 2013/2/15. N2 - Bone mineralization is a normal physiological process, whereas ectopic calcification of soft tissues is a pathological process that leads to irreversible tissue damage. We have established a coxsackievirus B3 (CVB3)-infected mouse model that manifests both osteoporosis and ectopic calcification specifically in heart, pancreas, and lung. The CVB3-infected mice showed increased serum concentrations of both cytokines including IL-1β, TNF-α, and the receptor activator of NF-κB ligand (RANKL) that stimulate osteoclast formation and of the osteoclast-derived protein tartrate-resistant ...
With local nerve compression, calcinosis cutis may cause neuropathic pain, and the presence of adjacent nerves should be a consideration in any excision of a deposition. Valenzuela, A, Chung L., Calcinosis. pathophysiology and management. Curr Opin Rheumatol. vol. 27. 2015 Nov. pp. 542-8. (The authors present an overview of recent studies regarding the epidemiology, pathophysiology, diagnosis, and treatment of calcinosis cutis in patients with systemic sclerosis.) Dima, A, Balanescu, P, Baicus, C. Pharmacological treatment in calcinosis cutis associated with connective-tissue diseases. Rom J Intern Med. vol. 52. 2014. pp. 55-67. (A review of pharmacological treatment options for calcinosis in patients with ACTD.) Del Barrio-Díaz, P, Moll-Manzur, C, Álvarez-Veliz, S, Vera-Kellet, C. Topical sodium metabisulfite for the treatment of calcinosis cutis: A promising new therapy. Br J Dermatol. 2016 Jan 22. (Case series of four patients with calcinosis cutis, secondary to dermatomyositis, ...
MalaCards based summary : Hyperphosphatemic Familial Tumoral Calcinosis, Fgf23-Related An important gene associated with Hyperphosphatemic Familial Tumoral Calcinosis, Fgf23-Related is FGF23 (Fibroblast Growth Factor 23 ...
Mitral annular calcification (MAC) and aortic annular calcification (AVC) may represent a manifestation of generalized atherosclerosis in the elederly. Alterations in vascular structure, as indexed by the intima media thickness (IMT), are also recognized as independent predictors of adverse cardiovascular outcomes. To examine the relationship between the degree of calcification at mitral and/or aortic valve annulus and large artery structure (thickness). We evaluated 102 consecutive patients who underwent transthoracic echocardiography and carotid artery echoDoppler for various indications; variables measured were: systemic blood pressure (BP), pulse pressure (PP=SBP-DBP), body mass index (BMI), fasting glucose, total, HDL, LDL chlolesterol, triglycerides, cIMT. The patients were divided according to a grading of valvular/annular lesions independent scores based on acoustic densitometry: 1 = annular/valvular sclerosis/calcification absence; 2 = annular/valvular sclerosis; 3 = annular calcification; 4 =
In addition to fibrosis, calcification is a defining feature of aortic valve lesions. Calcification may contribute to lesion rigidity, thereby worsening obstruction to left ventricular outflow. Moreover, the extent of lesion calcification correlates both with more rapid disease progression and worse clinical outcomes.61,62. Aortic valve calcification now has been shown unequivocally to be an active, rather than a passive, process. Valvular calcium deposits contain both calcium and phosphate11,57,63,63 as hydroxyapatite,57,63 the form of calcium-phosphate mineral present in both calcified arterial tissue64 and bone. Proteins involved in regulation of tissue calcification have been detected in calcified valvular tissue, including osteopontin,13,14 bone morphogenic proteins (BMPs) 2 and 4,15 and receptor activator of nuclear factor NF-κB ligand (RANKL).65 Osteoprotegrin (OPG), which prevents mineral resorption in bone tissue, is a soluble decoy receptor that resembles RANK and acts as a ...
INTRODUCTION. Soft tissue radiopacities include calcification, ossification or foreign objects. The latter are excluded from this manuscript. Calcification is the deposition of calcium salts in tissue. The pathogenesis is based on either dystrophic or metastatic mechanisms. Dystrophic calcification, which comprises the majority of soft tissue calcifications in the head and neck region, is the result of soft tissue damage with tissue degeneration and necrosis which attracts the precipitation of calcium salts. The blood calcium concentration in these patients is normal. Appropriate examples are calcification of a focus of necrosis of tuberculosis, necrotic tumour tissue or of atheromatous plaque.. Metastatic calcification on the other hand results from the deposition of calcium salts in normal tissue in the presence of hypercalcemia secondary to metabolic causes such as hyperparathyroidism and skeletal deposits of malignant disease. Metastatic calcifications are therefore generally spread more ...
Looking for coronary artery calcification? Find out information about coronary artery calcification. Any process of soil formation in which the soil colloids are saturated to a high degree with exchangeable calcium, thus rendering them relatively immobile... Explanation of coronary artery calcification
Background and Aim: Arterial calcification is often detected on ultrasound examination but its diagnostic accuracy is not well validated. The aim of this study was to determine the accuracy of carotid ultrasound B mode findings in detecting atherosclerotic calcification quantified by cone beam computed tomography (CBCT). Methods: We analyzed 94 carotid arteries, from 88 patients (mean age 70 ± 7 years, 33% females), who underwent pre-endarterectomy ultrasound examination. Plaques with high echogenic nodules and posterior shadowing were considered calcified. After surgery, the excised plaques were examined using CBCT, from which the calcification volume (mm3) was calculated. In cases with multiple calcifications the largest calcification nodule volume was used to represent the plaque. Carotid artery calcification by the two imaging techniques was compared using conventional correlations. Results: Carotid ultrasound was highly accurate in detecting the presence of calcification; with a sensitivity of 88
OBJECTIVE: To examine the correlation of plasma fibroblast growth factor (FGF)-23 and serum fetuin A levels with the coronary artery calcification score (CACS) in patients with normal kidney function. BACKGROUND: Vascular calcification is an active process that may be aggravated by hyperphosphataemia and hypercalcaemia. FGF-23 and human fetuin-A have been associated with calcifying arteriosclerosis in renal failure. Plasma FGF-23 was identified as an independent factor negatively associated with peripheral vascular calcification. Fetuin-A acts as a systemic inhibitor of ectopic calcification in dialysis patients and can be correlated to the survival of these patients. Very few data exists on the role of FGF-23 and fetuin-A in coronary calcification of patients without impaired kidney function. MATERIALS AND METHODS: Sixty-four patients, 21 females and 43 males, were subjected to 64-slice coronary computed tomography (CT) to evaluate coronary artery calcification (CAC). Plasma intact FGF-23 was ...
A method and system for detecting and displaying clustered microcalcifications in a digital mammogram, wherein a single digital mammogram is first automatically cropped to a breast area sub-image which is then processed by means of an optimized Difference of Gaussians filter to enhance the appearance of potential microcalcifications in the sub-image. The potential microcalcifications are thresholded clusters are detected, features are computed for the detected clusters, and the clusters are classified as either suspicious or not suspicious by means of a neural network. Thresholding is preferably by sloping local thresholding but may also be performed by global and dual-local thresholding. The locations in the original digital mammogram of the suspicious detected clustered microcalcifications are indicated. Parameters for use in the detection and thresholding portions of the system are computer-optimized by means of a genetic algorithm. The results of the system are optimally combined with a radiologist
Cardiovascular calcification is prevalent in the aging population and in patients with chronic kidney disease (CKD) and diabetes mellitus, giving rise to substantial morbidity and mortality. Vitamin K-dependent matrix Gla-protein (MGP) is an important inhibitor of calcification. The aim of this study was to evaluate the impact of high-dose menaquinone-7 (MK-7) supplementation (100 µg/g diet) on the development of extraosseous calcification in a murine model. Calcification was induced by 5/6 nephrectomy combined with high phosphate diet in rats. Sham operated animals served as controls. Animals received high or low MK-7 diets for 12 weeks. We assessed vital parameters, serum chemistry, creatinine clearance, and cardiac function. CKD provoked increased aortic (1.3 fold; p < 0.05) and myocardial (2.4 fold; p < 0.05) calcification in line with increased alkaline phosphatase levels (2.2 fold; p < 0.01). MK-7 supplementation inhibited cardiovascular calcification and decreased aortic alkaline
Background: Clinical evidence links arterial calcification and cardiovascular risk. Fibrous cap microcalcifications can promote atherosclerotic plaque failure, and large calcifications can stabilize the plaque. Therefore, calcification morphology can determine cardiovascular morbidity, but temporal patterns of calcific mineral deposition and growth remain unknown.. Results: Apolipoprotein E-deficient (Apoe-/-) mice on an atherogenic diet develop plaque calcification. Longitudinal studies were performed using two different fluorescent calcium tracers injected intravenously into Apoe-/- mice: calcein injection following 18 weeks of atherogenic diet (n=7) and alizarin red S injection into the same mice 1 (n=4) or 3 (n=3) weeks later. Imaging green (calcein) and red (alizarin red S) fluorescence provided snapshots of aortic calcification at 18, 19, and 21 weeks. Observations within histological sections revealed green microcalcifications at 18 weeks embedded within alizarin red stained larger ...
Pathological calcification Definition: it is the deposition of calcium salts in sites other than bones and teeth. Grossly: the calcified tissue appears chalky white and hard. Microscopically, the calcification appears as blue granules (with haematoxylin and eosin stain). There are two types of pathological calcification: 1. Dystrophic calcification: it is the most common type. Definition: […]. Tags: calcification, Pathological, type, unknown. ...
Two brothers aged 10 years and 18 years presented with multiple soft tissue calcareous swellings around the elbows, arms, knees, and forearms, which had been present for the last three years. Both were in good general health and there was no history of trauma. On examination, the younger boy had a calcified soft tissue swelling around the left knee joint with a sinus around the medial side of the knee. There was occasional discharge of white chalky material from the sinus. Movements at the knee were full and there was no neurovascular problem. The other brother had calcareous, firm, soft tissue swellings over the right lower thigh, left and right arms, and around both the elbow joints. Movements at the elbow and knee joints were normal and he had no discharging sinus. Their serum calcium, serum phosphorus, alkaline phosphatase, and urinary calcium were within normal limits. The erythrocyte sedimentation rate and the leukocyte count were normal. A test for lupus erythematosus was negative and ...
Microcalcifications are small. They often occur because of benign (not cancer) changes, but occasionally microcalcifications can be an early sign of cancer.. Macrocalcifications are larger. They usually occur because of benign (not cancer) changes and do not need to be investigated.. Breast calcifications are very common. They are usually due to benign (not cancer) changes that occur as part of aging.. Sometimes they form because of other benign changes in the breast, such as a fibroadenoma or breast cyst. They can also form if youve had an infection in your breast, if youve injured your breast, or if youve had surgery or a breast implant.. Breast calcifications can develop in the blood vessels of the breast. These may be age-related or caused by other medical conditions but dont usually require further assessment.. Breast calcifications are more common in women, but can also be found in men.. Occasionally, breast calcifications can be an early sign of cancer. Because of this, you may need ...
To the best of our knowledge, the present IVUS study is the first to demonstrate the relationship between calcification patterns, arterial remodeling, and the morphology of plaques within the culprit lesion segment. The major finding is that there is a significant difference in the pattern of coronary calcifications at the culprit lesion segment, particularly with respect to size, number, and length of the deposits, among patients with AMI, UAP, and SAP. Small calcium deposits were significantly more frequent in the culprit lesion segments in ACS than in SAP patients. In fact, our qualitative analysis of calcifications demonstrated that the culprit segments of AMI patients were mostly characterized by small calcium deposits, associated with fibrofatty plaques and PR.. Thus far, there have been few quantitative IVUS studies of coronary plaque calcification in lesions associated with ACS. Nakamura et al8 recently reported that lesser degrees of calcium were observed in the culprit lesions of ACS ...
Intervention study focused on preventing the progression of aortic valve calcification. Vascular and cardiac calcifications are a marker of risk and po
TY - JOUR. T1 - Significance of a positive family history for coronary heart disease in patients with a zero coronary artery calcium score (from the multi-ethnic study of atherosclerosis). AU - Cohen, Randy. AU - Budoff, Matthew. AU - McClelland, Robyn L.. AU - Sillau, Stefan. AU - Burke, Gregory. AU - Blaha, Michael. AU - Szklo, Moyses. AU - Uretsky, Seth. AU - Rozanski, Alan. AU - Shea, Steven. PY - 2014/10/15. Y1 - 2014/10/15. N2 - Although a coronary artery calcium (CAC) score of 0 is associated with a very low 10-year risk for cardiac events, this risk is nonzero. Subjects with a family history of coronary heart disease (CHD) has been associated with more subclinical atherosclerosis than subjects without a family history of CHD. The purpose of this study was to assess the significance of a family history for CHD in subjects with a CAC score of 0. The Multi-Ethnic Study of Atherosclerosis cohort includes 6,814 participants free of clinical cardiovascular disease (CVD) at baseline. Positive ...
Background Limited information is available regarding genetic contributions to valvular calcification, which is an important precursor of clinical valve disease. Methods We determined genomewide associations with the presence of aortic-valve calcification (among 6942 participants) and mitral annular calcification (among 3795 participants), as detected by computed tomographic (CT) scanning; the study population for this analysis included persons of white European ancestry from three cohorts participating in the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium (discovery population). Findings were replicated in independent cohorts of persons with either CT-detected valvular calcification or clinical aortic stenosis. Results One SNP in the lipoprotein(a) (LPA) locus (rs10455872) reached genomewide significance for the presence of aortic-valve calcification (odds ratio per allele, 2.05; P = 9.0x10(-10)), a finding that was replicated in additional white European, ...
2017, Springer Science+Business Media B.V., part of Springer Nature. Purpose: Vascular calcification is common in chronic kidney disease (CKD) and predicts poor patient outcomes. While computed tomography is the gold standard for evaluation of vascular calcification, plain radiograph offers a simpler and less costly alternative. The calcification of abdominal aorta, iliac and femoral arteries has been evaluated by plain radiograph, but the data on their outcome predictabilities are still limited. The present study investigated the role of abdominal aortic calcification (AAC) and pelvic arterial calcification (PAC) in predicting overall morality in non-dialysis CKD stages 2-5 (CKD 2-5), maintenance hemodialysis (HD) and long-term kidney transplant (KT) patients. Methods: Four hundred and nineteen patients were included. Lateral abdominal and pelvic radiographs were obtained. The degree of AAC and PAC was evaluated according to the methods described previously by Kaupplia et al. and Adragao et al. ...
Cardiovascular diseases represent the most common cause of global mortality (31%), affecting both developed and developing countries, claiming the lives of an estimated 17.5 million people in 2012 (1-3). Among the predictors for cardiovascular morbidity and mortality, cardiovascular calcification is an independent risk factor. Many pathologies, such as atherosclerosis, diabetes mellitus, and chronic kidney disease, are often associated with cardiovascular calcification (4, 5), which can occur in blood vessels, the myocardium, and cardiac valves. In blood vessels, calcification typically occurs in intimal atherosclerotic plaques and in the tunica media (4, 6-8).. In the past two decades, research has highlighted the active inflammatory and/or osteogenic signaling processes that contribute to pathological cardiovascular calcification, shifting the paradigm away from that of a passive accumulation of minerals (9, 10). However, very little is known about the mechanism of nonpathological mineral ...
In a study to ascertain whether breast arterial calcification (BAC) detected with digital mammography correlates to chest CT findings of coronary artery calcification (CAC), researchers have discovered a striking relationship between the two factors. In 76 percent of the study cohort, women who had a BAC score of 0 also had a CAC score of 0. As the BAC score increases, there is a concomitant increase in the CAC score.
Background: Recent guidelines have suggested that presence of coronary artery calcium (CAC) is an independent marker of adverse cardiovascular disease (CVD) events and mortality. However the predictive value of thoracic aorta calcification (TAC) that can be additionally identified without further scanning during assessment of CAC is unknown.. Method: We followed a cohort of 8418 asymptomatic individuals (mean age: 53 ± 10 years, 69% men) undergoing cardiac risk factor evaluation and coronary calcium testing with electron-beam CT for median period of 5.0 years. Multivariable Cox proportional hazards models were developed to predict all-cause mortality obtained from the National Death Index with presence of TAC.. Results: 141 (2%) all cause deaths were recorded. Overall survival was 96.7% and 98.8% for subjects with and without detectable TAC (p , 0.0001). As compared to those with absent TAC (reference group) the hazard ratio for mortality for subjects with TAC was 3.07 (95% CI: 2.20 - 4.38) in ...
BACKGROUND:. This study is ancillary to the MultiEthnic Study of Atherosclerosis (MESA) Trial, a prospective investigation of the etiology and natural history of atherosclerosis and the ability of non-invasive tools to measure atherosclerotic burden and identify high risk individuals in a large, population-based cohort. The development of computed tomography (CT) to evaluate coronary calcification (CC) now provides a tool to directly measure coronary atherosclerosis non-invasively. The information obtained by CT however provides more information than CC alone. CT has the ability to measure and quantitate aortic valve calcification (AVC), mitral annular calcification (MAC), aortic wall calcification and left ventricular size (LVS). The longitudinal nature of this study will allow epidemiologic associations to be established for a multitude of risk factors and these measures, establishing both the time sequence for each measure and consistency of the association in a variety of populations ...
BACKGROUND:. This study is ancillary to the MultiEthnic Study of Atherosclerosis (MESA) Trial, a prospective investigation of the etiology and natural history of atherosclerosis and the ability of non-invasive tools to measure atherosclerotic burden and identify high risk individuals in a large, population-based cohort. The development of computed tomography (CT) to evaluate coronary calcification (CC) now provides a tool to directly measure coronary atherosclerosis non-invasively. The information obtained by CT however provides more information than CC alone. CT has the ability to measure and quantitate aortic valve calcification (AVC), mitral annular calcification (MAC), aortic wall calcification and left ventricular size (LVS). The longitudinal nature of this study will allow epidemiologic associations to be established for a multitude of risk factors and these measures, establishing both the time sequence for each measure and consistency of the association in a variety of populations ...
Calcinosis cutis is a descriptive term for the deposition of insoluble calcium salts in the cutaneous and subcutaneous tissue. Based upon the etiology of calcium deposition, there are five subtypes of calcinosis cutis: dystrophic, metastatic, idiopat
Is this going to be okay? From what I understand, lots of babies can have this and turn out absolutely normal. The doctor told me everything was measuring properly and that the baby was actually measuring in at 20 weeks but that there were two calcium deposits in the heart? Calcium Deposit In The Fetus S Heart. The fetal heart rate (FHR) is usually faster as compared to the heart rate of an adult. First, I have a placenta previa (the doctor says there is a good chance this will change before delivery) and the second is a calcium deposit in the babys heart, which my doc says could be a sign of Downs Syndrome. Calcifications were mainly located in the liver (57%), but also in heart (13%), bowel (6%) and other tissues. The cause of EIF is unknown, but the condition is generally harmless. So this morning we had our 20 week ultrasound. for the most part is measuring good and most is fine. Q: Tests showed that the baby has calcium deposits in the heart at 20 weeks. Echogenic intracardiac focus (EIF) ...
This 15 year longitudinal study provides insights into the relationship between coronary artery calcification and diabetes mellitus. Abstract Background Data regarding coronary artery calcification (CAC) prognosis in diabetic individuals are limited to 5-years follow-up. We investigated the long-term risk stratification of CAC among diabetic compared with nondiabetic individuals. Methods and Results Nine thousand seven…
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In a previous study ([17]) performed in the same patient group as that in the present study, the total coronary calcification score predicted coronary stenosis. The sensitivity, specificity, PPV, NPV and accuracy of the total calcification score were 0.77, 0.86, 0.86, 0.76 and 0.81, respectively. The sensitivity (0.75), specificity (0.81) and accuracy (0.80) of calcification for prediction of significant stenosis was similar in the present study, but the PPV (0.36) was significantly lower (p , 0.0001 by chi-square analysis) and the NPV (0.96) significantly higher (p , 0.0001). These differences were revealed by the site by site comparison. As in our previous study ([17]), the prevalence and amount of coronary calcification increased with age, even in patients without significant stenosis. These findings may explain why the PPV and sensitivity increased significantly with age for all atherosclerotic lesions. The PPV and sensitivity did not increase with age for significant stenosis. Although the ...
CALCINOSIS CUTIS TREATMENT PDF - BACKGROUND: Dystrophic calcinosis cutis is a common manifestation in connective tissue diseases, but theres still no consensus on treatment. OBJECTIVES.
TY - JOUR. T1 - Relationship of bone mineral density with valvular and annular calcification in community-dwelling older people. T2 - The Cardiovascular Health Study. AU - Massera, Daniele. AU - Xu, Shuo. AU - Bartz, Traci M.. AU - Bortnick, Anna E.. AU - Ix, Joachim H.. AU - Chonchol, Michel. AU - Owens, David S.. AU - Barasch, Eddy. AU - Gardin, Julius M.. AU - Gottdiener, John S.. AU - Robbins, John A. AU - Siscovick, David S.. AU - Kizer, Jorge R.. PY - 2017/12/1. Y1 - 2017/12/1. N2 - Summary: Associations between bone mineral density and aortic valvular, aortic annular, and mitral annular calcification were investigated in a cross-sectional analysis of a population-based cohort of 1497 older adults. Although there was no association between continuous bone mineral density and outcomes, a significant association between osteoporosis and aortic valvular calcification in men was found. Introduction: The process of cardiac calcification bears a resemblance to skeletal bone metabolism and its ...
The present study examined the diagnostic performance of FFRCT at various levels of coronary calcification for the identification and exclusion of ischemia-causing lesions using FFR as the reference standard. The 2 major findings of this study were: 1) FFRCT provided high per-patient and per-vessel diagnostic performance and discrimination for ischemia over a wide range of coronary calcification severity; and 2) the diagnostic performance of FFRCT was superior to coronary CTA stenosis interpretation regardless of the AS level.. Because the presence of myocardial ischemia is associated with a poor prognosis (23), current guidelines recommend noninvasive functional imaging testing as the first-line strategy in patients with suspected stable CAD (21). However, shortcomings of current noninvasive diagnostic strategies are apparent from the frequent inaccurate selection of patients for ICA (24,25). To date, FFR is the only diagnostic tool shown to improve clinical outcomes and to reduce health care ...
Idiopathic Infantile Arterial Calcification (IIAC) also known as Arterial Calcification of Infancy, Generalised Infantile Arterial Calcification (GACI), Idiopathic Arterial Calcification of Infancy (IACI), Occlusive Infantile Arterial Calcification, Occlusive Infantile Arteriopathy is an extremely rare, usually fatal genetic disorder, caused by mutations in the ENPP1 gene in 75% of the subjects. The condition affects infants during the first 6 months of life. This condition is inherited as an autosomal recessive pattern. It is characterized by generalised calcification of the arterial internal elastic lamina, leading to rupture of the lamina and occlusive changes in the tunica intima with stenosis and decreased elasticity of the vessel wall. Most infants die of vaso-occlusive disease, especially of the coronary arteries. Clinical presentation is variable. First symptoms usually occur at birth but can take place in the first 6 months of life or in utero. Decreased fetal activity Gestation with an ...
DESIGN: Diet was assessed between 1990 and 1993 by using a semiquantitative 170-item food-frequency questionnaire. Coronary calcification was assessed approximately 7 y later by electron-beam computed tomography in 1570 asymptomatic cardiac subjects with complete dietary data (44% men, mean age of 64 y). Calcium scores according to Agatstons method were divided into < or = 10 (no/minimal coronary calcification), 11-400 (mild/moderate calcification), and > 400 (severe calcification). Prevalence ratios (PRs) for mild/moderate and severe calcification were obtained in categories of fish and EPA plus DHA intake. PRs were adjusted for age, sex, body mass index, diabetes mellitus, socioeconomic status, smoking, alcohol intake, physical activity, and dietary factors ...
A database of 145 mammograms containing biopsy proven malignant or benign microcalcifications was digitized with a laser scanner at a pixel size of 35 micrometer by 35 micrometers. Digitization at larger pixel sizes was simulated by averaging adjacent pixels. The individual microcalcifications were segmented from the digital images with region growing and adaptive gray level thresholding techniques. The characteristics of the individual microcalcifications were analyzed with visibility descriptors and shape descriptors. The variations of visibility and shape of the microcalcifications in a cluster were evaluated by the standard deviation, the coefficient of variation, and the maximum of each of the descriptors. In addition, texture features were extracted from the spatial gray level dependence (SGLD) matrices in the region containing the cluster of microcalcifications. A genetic algorithm (GA) was used to select features from the multidimensional morphological and texture feature space. Linear ...
Comments, concepts and statistics about Fibroblast growth factor 23 is associated with carotid artery calcification in chronic kidney disease patients not undergoing dialysis: a cross-sectional study.
Since Rocaltrol is believed to be the active hormone which exerts vitamin D activity in the body, adverse effects are, in general, similar to those encountered with excessive vitamin D intake, ie, hypercalcemia syndrome or calcium intoxication (depending on the severity and duration of hypercalcemia). Normalization of elevated serum calcium occurs within a few days of treatment withdrawal (ie, faster than in treatment with vitamin D3 preparations). Chronic hypercalcemia may lead to generalized calcification, nephrocalcinosis and other soft tissue calcification. The serum calcium times phosphate (Ca X P) product should not exceed 70 mg2/dL2. Overdose may require immediate medical attention ...
Since Rocaltrol is believed to be the active hormone which exerts vitamin D activity in the body, adverse effects are, in general, similar to those encountered with excessive vitamin D intake, ie, hypercalcemia syndrome or calcium intoxication (depending on the severity and duration of hypercalcemia). Normalization of elevated serum calcium occurs within a few days of treatment withdrawal (ie, faster than in treatment with vitamin D3 preparations). Chronic hypercalcemia may lead to generalized calcification, nephrocalcinosis and other soft tissue calcification. The serum calcium times phosphate (Ca X P) product should not exceed 70 mg2/dL2. Overdose may require immediate medical attention ...
Vascular and valvular calcification are commonly encountered in clinical medicine and a greater understanding of their significance and pathophysiology remain a subject of immense importance. In the coronary arteries, vascular calcification burden correlates with the severity of luminal stenosis and atherosclerotic plaque burden. While in progressive lesions, the presence of coronary calcification is not binary but rather depends on the type of calcification. Racial and gender differences, and comorbidities like diabetes mellitus and chronic kidney disease, all affect the presence and severity of calcification. The peripheral arteries of the lower extremities are affected by both medial calcification and intimal calcification, and the former barely contributes to luminal stenosis. The character of atherosclerosis differs between above-knee and below-knee lesions. Valvular calcification generally occurs on the aortic valve leaflets, and pathologic findings range from minimal fibrocalcific changes in
As a new feature of CNNhealth.com, our team of expert doctors will answer readers questions. Heres a question for Dr. Gupta. Asked by Collin, Oak Park, Illinois Im in my 40s and was told I have cardiac calcification.
As a new feature of CNNhealth.com, our team of expert doctors will answer readers questions. Heres a question for Dr. Gupta. Asked by Collin, Oak Park, Illinois Im in my 40s and was told I have cardiac calcification.
Materials and Methods: A retrospective study of seven patients of tumoral calcinosis treated with complete surgical excision over a period of 1 year was done. Demographic details were compiled. Routine blood investigations were performed. All patients underwent radiographs and magnetic resonance imaging (MRI) scans of involved part. We did not perform computed tomography (CT) or bone scan in any of our patients. All seven patients underwent surgery and were followed up till 2 years ...
Aortic valve calcification (AVC) without outflow obstruction (stenosis) is common in the elderly and increases the risk of cardiovascular morbidity and mortality. Although high blood pressure (BP) measured at the doctors office is known to be associated with AVC, little is known about the association between 24-hour ambulatory BP (ABP) and AVC. Our objective was to clarify the association between ABP variables and AVC. The study population consisted of 737 patients (mean age, 71±9 years) participating in the Cardiovascular Abnormalities and Brain Lesions study who underwent 24-hour ABP monitoring. Each aortic valve leaflet was graded on a scale of 0 (normal) to 3 (severe calcification). A total valve score (values 0-9) was calculated as the sum of all leaflet scores. Advanced AVC (score ≥4) was present in 77 subjects (10.4%). All of the systolic ABP variables (except systolic BP nocturnal decline) and mean asleep diastolic BP were positively associated with advanced calcification, whereas normal
Background: Recent studies showed that the assessment of aortic valve calcification (AVC) by multidetector computed tomography (MDCT) is useful to corroborate hemodynamic severity of aortic stenosis (AS). AVC load might provide incremental value beyond clinical and echocardiographic parameters of AS severity to predict hemodynamic progression and occurrence of valve-related events.. Methods: Three hundred twenty three patients (68±13 yrs, 70% men) with AS were prospectively enrolled in 2 academic centers. Hemodynamic AS progression was assessed by annualized increase in mean gradient (MG) measured by echocardiography. AVC was measured by MDCT using the Agatston method and was indexed to the cross-sectional area of the aortic annulus to obtain AVC density (AVCd).. Results: Patients with rapid progression (MG progression ≥3.0 mmHg/yr, median for the cohort) had higher AVCd at baseline as compared to those with slow progression (median [IQR]: AVCd: 322 [160-508] vs 175 [84-309] AU/cm2; ...
Looking for online definition of apocrine cystic calcinosis in the Medical Dictionary? apocrine cystic calcinosis explanation free. What is apocrine cystic calcinosis? Meaning of apocrine cystic calcinosis medical term. What does apocrine cystic calcinosis mean?
The association of aortic valve calcification (AVC) with dementia remains unknown. In 2,428 non-demented participants from the population-based Rotterdam Study, we investigated the association of CT-assessed AVC with risk of dementia and cognitive decline. AVC was present in 33.1% of the population. During a median follow-up of 9.3 years, 160 participants developed dementia. We found no association between presence of AVC and risk of all-cause dementia [hazard ratio (HR): 0.89 (95% confidence interval (CI):0.63;1.26)]. Presence of AVC was not associated with cognitive decline on any of the cognitive tests, nor with a measure of global cognition. ...
Hyperphosphatemic familial tumoral calcinosis (HFTC)/hyperostosis-hyperphosphatemia syndrome (HHS) is an autosomal recessive disorder of ectopic calcification due to deficiency of or resistance to intact fibroblast growth factor 23 (iFGF23). Inactivating mutations in FGF23, N-acetylgalactosaminyltransferase 3 (GALNT3), or KLOTHO (KL) have been reported as causing HFTC/HHS. We present what we believe is the first identified case of autoimmune hyperphosphatemic tumoral calcinosis in an 8-year-old boy. In addition to the classical clinical and biochemical features of hyperphosphatemic tumoral calcinosis, the patient exhibited markedly elevated intact and C-terminal FGF23 levels, suggestive of FGF23 resistance. However, no mutations in FGF23, KL, or FGF receptor 1 (FGFR1) were identified. He subsequently developed type 1 diabetes mellitus, which raised the possibility of an autoimmune cause for hyperphosphatemic tumoral calcinosis. Luciferase immunoprecipitation systems revealed markedly elevated ...
Hyperphosphatemic familial tumoral calcinosis (HFTC)/hyperostosis-hyperphosphatemia syndrome (HHS) is an autosomal recessive disorder of ectopic calcification due to deficiency of or resistance to intact fibroblast growth factor 23 (iFGF23). Inactivating mutations in FGF23, N-acetylgalactosaminyltransferase 3 (GALNT3), or KLOTHO (KL) have been reported as causing HFTC/HHS. We present what we believe is the first identified case of autoimmune hyperphosphatemic tumoral calcinosis in an 8-year-old boy. In addition to the classical clinical and biochemical features of hyperphosphatemic tumoral calcinosis, the patient exhibited markedly elevated intact and C-terminal FGF23 levels, suggestive of FGF23 resistance. However, no mutations in FGF23, KL, or FGF receptor 1 (FGFR1) were identified. He subsequently developed type 1 diabetes mellitus, which raised the possibility of an autoimmune cause for hyperphosphatemic tumoral calcinosis. Luciferase immunoprecipitation systems revealed markedly elevated ...
BACKGROUND: Peripheral arterial disease and vascular calcifications contribute significantly to the outcome of dialysis patients. The aim of this study was to evaluate the prognostic role of severity of abdominal aortic calcifications and peripheral arterial disease on outcome of peritoneal dialysis (PD) patients using methods easily available in everyday clinical practice.. METHODS: We enrolled 249 PD patients (mean age 61 years, 67% male) in this prospective, observational, multicenter study from 2009 to 2013. The abdominal aortic calcification score (AACS) was assessed using lateral lumbar X ray, and the ankle-brachial index (ABI) using a Doppler device.. RESULTS: The median AACS was 11 (range 0 - 24). In 58% of the patients, all 4 segments of the abdominal aorta showed deposits, while 19% of patients had no visible deposits (AACS 0). Ankle-brachial index was normal in 49%, low (, 0.9) in 17%, and high (, 1.3) in 34% of patients. Altogether 91 patients (37%) died during the median follow-up ...
Association of epicardial fat, hypertension, subclinical coronary artery disease, and metabolic syndrome with left ventricular diastolic dysfunction
What follows is a listing of factors that are active at different points of the proposed mechanisms of calcification. At present it is impossible to outline the most important ones.. Periostin is found in VICs from healthy bovine aortic valves, but expression increases following exposure to LPS. Periostin is chiefly expressed in VICs of the lamina ventricularis, less in the fibrosa, and is coexpressed with elastin.57 Periostin is secreted by macrophages and myofibroblasts, and it stimulates expression of MMP‐2 and ‐9 in human VICs. Wild‐type mice fed with the Western diet develop aortic stenosis, but periostin‐knockout mice do not. In addition, they express lower levels of αSMA, collagen 1, and MMP‐2 and ‐13.57 Periostin may thus play a stimulatory role in the development of valve calcification.. Jian and colleagues showed that whereas healthy aortic valves did not express MMP‐2 or ALP, diseased valves expressed both, as well as tenascin‐C, an extracellular matrix glycoprotein ...
TY - JOUR. T1 - Very low density lipoprotein cholesterol associates with coronary artery calcification in type 2 diabetes beyond circulating levels of triglycerides. AU - Prenner, Stuart B.. AU - Mulvey, Claire K.. AU - Ferguson, Jane F.. AU - Rickels, Michael R.. AU - Bhatt, Anish B.. AU - Reilly, Muredach P.. PY - 2014/10/1. Y1 - 2014/10/1. N2 - Objective: While recent genomic studies have focused attention on triglyceride (TG) rich lipoproteins in cardiovascular disease (CVD), little is known of very low-density lipoprotein cholesterol (VLDL-C) relationship with atherosclerosis and CVD. We examined, in a high-risk type-2 diabetic population, the association of plasma VLDL-C with coronary artery calcification (CAC). Methods: The Penn Diabetes Heart Study (PDHS) is a cross-sectional study of CVD risk factors in type-2 diabetics (n = 2118, mean age 59.1 years, 36.5% female, 34.1% Black). Plasma lipids including VLDL-C were calculated (n = 1879) after ultracentrifugation. Results: In Tobit ...
Vascular calcification is prevalent in diabetes mellitus and is correlated with adverse cardiovascular outcome32,33; however, the molecular mechanisms underlying increased vascular calcification in diabetes mellitus are largely unknown. Elevation of O-GlcNAcylation is found in human diabetic carotid plaques20 and diabetic mouse vasculature.34 Coincidently, increased vascular calcification has been identified in patients with both type I and type II diabetes mellitus35 and diabetic mouse models.6 Nevertheless, the role of O-GlcNAcylation in vascular calcification has not been previously determined. The present study has demonstrated a causative effect of O-GlcNAcylation on diabetic vascular calcification. Our studies revealed that the activation of AKT by O-GlcNAcylation in vasculature is a key to diabetic vascular calcification. Two novel O-GlcNAcylation sites on AKT play a crucial role in enhancing AKT phosphorylation at S473 to increase vascular calcification. Because O-GlcNAcylation is ...
Radiographic findings in the extremities include acroosteolysis, soft tissue calcifications (calcinosis), and atrophy of the distal finger tips. Compared with hand involvement in scleroderma, foot involvement has a later onset and is relatively less frequent but can be disabling. Soft tissue changes included flexion deformities, generalized or localized atrophy, and dystrophic calcifications. In a study by Bassett et al.[1], resorption of distal phalanges was the most common bony change in patients with scleroderma, though osteolysis in other sites (feet, ribs, and mandibles) was also frequent. Nearly 20% showed radiographic evidence of inflammatory arthritis and joint destruction that could not be attributed to overlap with rheumatoid arthritis or mixed connective tissue disease.. Radiographic findings of other organ systems include fibrosis in the lungs and abnormal esophogram related to dysmotility.. File:Scleroderma.jpg. ...
Looking for online definition of arterial calcification, generalised, of infancy type 2 in the Medical Dictionary? arterial calcification, generalised, of infancy type 2 explanation free. What is arterial calcification, generalised, of infancy type 2? Meaning of arterial calcification, generalised, of infancy type 2 medical term. What does arterial calcification, generalised, of infancy type 2 mean?
Involvement of the basal ganglia in AIDS encephalopathy is well documented in both adults and children. The pathology remains obscure. A type of inflammation with increased vascularity and disruption of the blood-brain barrier has been postulated. Calcification of the basal ganglia in encephalopathic HIV / AIDS children has been relatively well documented. Only two adult HIV cases with basal ganglion calcification (BGC) have been reported in the literature. At our institution over the past few years, we have noted an increasing number of adult AIDS patients with neurological complications, demonstrating BGC on CT examination. A retrospective review was done. Ninety-six adult cases were identified with BGC. Of these, 38 patients were HIV positive. Review of the 38 HIV-positive cases revealed that all of the patients presented clinically with encephalopathic symptoms, and all showed BGC associated with varying degrees of atrophy on CT scan. Reports of paediatric HIV cases with BGC and encephalopathy have
Mean follow-up was 3.1 ± 2.6 years, with 440 AVRs and 194 deaths. High AVC density was associated with increased aortic valve peak velocity, higher mean gradient, and decreased valve area (p < 0.001 for each). Severe versus nonsevere AVC was associated with reduced 5-year survival in those treated medically (41 ± 6% vs. 78 ± 6%, p < 0.001). On multivariate analysis, severe AVC (hazard ratio [HR], 1.75; 95% confidence interval [CI], 1.04-2.92; p = 0.03) and severe AVC density (HR, 2.44; 95% CI, 1.37-4.37; p = 0.002) were independently associated with increased mortality in patients treated medically. For survival regardless of AVR, both severe AVC (HR, 1.71; 95% CI, 1.12-2.62; p = 0.01) and severe AVC density (HR, 2.22; 95% CI, 1.37-4.37; p = 0.002) remained associated with increased mortality; both of these variables remained statistically significant when adjusted for coronary artery calcium score in the subset with this available (p < 0.05 for each). Multivariable analysis observed that ...
Relief is when you and the right researcher find each other Finding the right clinical trial for Basal ganglia calcification, idiopathic, 3 can be challenging. However, with TrialsFinder (which uses the Reg4ALL database and privacy controls by Private Access), you can permit researchers to let you know opportunities to consider - all without revealing your identity. ...
In this issue of iJACC, Silverman et al. (1) report the relationship of baseline Agatston coronary artery calcium (CAC) score and coronary calcium distribution with future incident coronary revascularization in 6,540 MESA (Multi-Ethnic Study of Atherosclerosis) participants. The primary findings of this novel analysis is that baseline calcium score and the number of vessels with CAC were each independently predictive of future coronary revascularizations over a median follow-up of 8.5 years. Additionally, among subjects who underwent revascularization, those with more diffuse baseline CAC were at higher risk to undergo coronary artery bypass graft (CABG) versus percutaneous coronary intervention (PCI). Specifically, adjusted for overall CAC score, individuals with 3- and 4-vessel CAC were 3 to 4 times more likely to undergo coronary revascularization than were patients with CAC in a single vessel, and ≥3 vessel CAC was strongly predictive of the risk for future CABG, particularly when ...
Disorders of calcium-phosphate-parathormone balance, are very important issues in ESRD patients, that may lead to severe complications, as dystrophic calcinosis cutis, a rare disease, caused by calcium salt deposits in cutaneous or subcutaneous tissues and many organs.. We present the case of a 47 years old woman, in ESRD due to membranous glomerulopathy, treated by peritoneal dialysis, who, after 7 months of dialysis, developed painful masses on second finger and fifth metacarpus of the right hand.. Laboratory and instrumental data showed hyperparathyroidism with a parathyroid mass consistent with adenoma.. Increasing of therapy with phosphate binders and cinacalcet only, was not effective to solve cutaneous masses, that were biopsied. Histological exam revealed deposition of amorphic material with calcific component, consistent with cutaneous dystrophic calcinosis.. We further increased dialysis and therapy and we observed complete regression of masses in 2 months.. Key words: dystrophic ...
THESIS:. Objective: assess the prevalence of thoracic aortic calcification and aneurysm in patients in lung cancer screening.. Materials and methods: the retrospective study included randomly selected results of ultra-low-dose computed tomography of 254 patients.. Results: quantitative analysis of aortic calcination by Agatston, Volume, Mass index, as well as qualitative and quantitative analysis of aortic aneurysm occurrence in lung cancer screening was performed.. Conclusion: it is necessary to pay attention to the presence of thoracic aorta calcification and aneurysm in lung cancer screening, as these changes are closely associated with a high risk of cardiovascular diseases leading to death.. KEYWORDS: Aortic calcification, Aortic aneurysm, Ultra-low-dose computed tomography.. CORRESPONDING AUTHOR: Korkunova O. A. E-MAIL: [email protected] FOR CITATIONS: Korkunova O. A., Suchilova M. M., Nikolayev A. E., Grishkov S. M., Gombolevskiy V. А., Bosin V. Yu. - Aortic calcification and ...
Korean researchers have recently shown that drinking coffee is linked to lower arterial calcification (calcium deposits in vascular walls). Arterial calcification predicts increased cardiovascular risk, independent of the usual cardiovascular risk factors, and so its very important to prevent it.. The link between coffee consumption and prevalence of coronary artery calcium (CAC) was examined in 25 138 men and women (mean age 41.3 years). The subjects had no clinically evident cardiovascular disease, and CAC scores were determined by computed tomography. CT scans showed that 13.4% of subjects had detectable coronary artery calcium. The mean coffee consumption was 1.8 cups per day.. The study showed that coffee drinkers had lower coronary artery calcium scores, as compared to noncoffee drinkers. Those that drank 3 or 4 cups per day had the lowest coronary artery calcium scores. This link was similar inmen and women and for subgroups defined by age, weight, smoking status, alcohol consumption, ...
High coronary calcium score and post-procedural CK-MB are noninvasive predictors of coronary stent restenosis Jae-Beom Lee,1 Yun-Seok Choi,2 Woo-Baek Chung,2 Ami Kwon,2 Chul-Soo Park,2 Man-Young Lee2 1Anyang Sam Hospital, 2Division of Cardiology, Department of Internal Medicine, Youido St Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea Purpose: High coronary calcium score (CCS) and post-procedural cardiac enzyme may be related with poor outcomes in patients with coronary stent implantation. Methods: A total of 1,072 patients (63.2% male, mean age: 61.7±10.3 years) who underwent coronary multi-detect computed tomography at index procedure and follow-up coronary angiography (CAG) after drug-eluting stent (DES) were divided into two groups: those with and without target lesion revascularization (TLR; >50% reduction in luminal stent diameter or angina symptoms on follow-up CAG). The CCSs for predicting stent revascularization were elucidated. Results:
Vascular calcification refers to the abnormal deposition of calcium phosphate salts in blood vessels, myocardium, and cardiac valves. Vascular calcification can be life-threatening, as in the case of generalized infantile arterial calcification, calcific uremic arteriolopathy, and calcific valve disease.1,2 In atherosclerotic lesions, calcification is mainly found in the intima of blood vessels as dispersed punctate or patchy crystals associated with the necrotic core of atheromas (intimal calcification) and has been shown to positively correlate to the atherosclerotic plaque burden and the increased risk of myocardial infarction.3 Calcium phosphate salts deposit also in the media of blood vessels, known as Monckebergs medial sclerosis (medial calcification), and is prevalent in aging and patients with chronic kidney disease and type 2 diabetes mellitus.2,4,5 Medial calcification in these patients can occur independently of intimal calcification and/or atherosclerotic lesions and features ...
Objective: Matrix Gla protein (MGP) is reported to inhibit bone morphogenetic protein (BMP) signal transduction. MGP deficiency is associated with medial calcification of the arterial wall, in a process that involves both osteogenic transdifferentiation of vascular smooth muscle cells (VSMCs) and mesenchymal transition of endothelial cells (EndMT). In this study, we investigated the contribution of BMP signal transduction to the medial calcification that develops in MGP-deficient mice. Approach and Results MGP-deficient mice (MGP-/-) were treated with one of two BMP signaling inhibitors, LDN-193189 or ALK3-Fc, beginning one day after birth. Aortic calcification was assessed in 28-day-old mice by measuring the uptake of a fluorescent bisphosphonate probe and by staining tissue sections with Alizarin red. Aortic calcification was 80% less in MGP-/- mice treated with LDN-193189 or ALK3-Fc compared with vehicle-treated control animals (P,0.001 for both). LDN-193189-treated MGP-/- mice survived ...
Definition of Physiological intracranial calcification with photos and pictures, translations, sample usage, and additional links for more information.
TY - JOUR. T1 - Ethnic Differences in the Prognostic Value of Coronary Artery Calcification for All-Cause Mortality. AU - Nasir, Khurram. AU - Shaw, Leslee J.. AU - Liu, Sandy T.. AU - Weinstein, Steven R.. AU - Mosler, Tristen R.. AU - Flores, Phillip R.. AU - Flores, Ferdinand R.. AU - Raggi, Paolo. AU - Berman, Daniel S.. AU - Blumenthal, Roger S.. AU - Budoff, Matthew J.. N1 - Copyright: Copyright 2008 Elsevier B.V., All rights reserved.. PY - 2007/9/4. Y1 - 2007/9/4. N2 - Objectives: The purpose of this study was to evaluate the prognostic value of coronary artery calcium (CAC), a known marker of subclinical atherosclerosis, in a large, ethnically diverse cohort of 14,812 patients for the prediction of all-cause mortality. Background: Disparities in case fatality rates for heart disease among ethnic groups are well known. In 2001, rates of death from heart disease were 30% higher among African Americans (AA) than non-Hispanic whites (NHW). Some of this variability may be due to differing ...
Aortic calcification was demonstrated in experimental animal models of hyperhomocysteinemia. Mild hyperhomocysteinemia was associated with aortic calcification, suggesting a relationship between homocysteine (HCY) and the pathogenesis of aortic calcification. In the present study, the effect of HCY on vascular calcification was examined in calcifying and non-calcifying vascular smooth muscle cells (VSMCs). Cell calcification was induced by incubation of VSMCs with [ glycerophosphate. Proliferation of VSMCs was studied by cell counting, H-3-thymidine (H-3-TdR) and H-3-leucine (H-3-Leu) incorporation. Ca-45 accumulation, cell calcium content, and alkaline phosphatase (ALP) activity were measured as indices of calcification. The results showed that the proliferation of calcifying VSMCs, which was indicated by cell counting, H-3-TdR and H-3-Leu incorporation in calcifying VSMCs, was enhanced as compared with that of non-calcifying VSMCs. HCY promoted increases in cell number, H-3-TdR and H-3-Leu ...
Association of serum phosphorus, calcium and parathyroid hormone with cardiovascular calcification in regular hemodialysis patients
Cardiovascular Calcification And Bone Mineralization è un libro di Aikawa Elena (Curatore), Hutcheson Joshua D. (Curatore) edito da Humana a luglio 2021 - EAN 9783030467272: puoi acquistarlo sul sito HOEPLI.it, la grande libreria online.
Sigma-Aldrich offers abstracts and full-text articles by [R Vongpromek, S Bos, G-J R Ten Kate, R Yahya, A J M Verhoeven, P J de Feyter, F Kronenberg, J E Roeters van Lennep, E J G Sijbrands, M T Mulder].
Contrary to the general assumption, we found that PPi has bioavailability in humans and mice when administered orally (Fig 1). The observed transient elevation found in healthy volunteers (Fig 1A) indicates that in both GACI and in PXE patients, PPi levels may be transiently raised to the physiological level when 67 or 98 mg Na4PPi/kg of body weight is taken. Importantly, it has been shown that inhibition of calcification in uremic rats and in PXE mice can be achieved by daily intraperitoneal injections of PPi triggering transient increase in plasma PPi levels (ONeill et al, 2011; Pomozi et al, 2017). We determined a t1/2 = 44.7 min what is rather similar to that published in rat (34.1 min; ONeill et al, 2011).. We also demonstrated significant attenuation of calcification in two different well‐characterized mouse models of ectopic calcification disorders, PXE and GACI when the animals were treated with pyrophosphate orally. Furthermore, we demonstrated PPi uptake from the oral cavity and ...
The geminal bisphosphonates are a new class of drugs characterised by a P-C-P bond. Consequently, they are analogues of pyrophosphate, but are resistant to chemical and enzymatic hydrolysis. The bisphosphonates bind strongly to hydroxyapatite crystals and inhibit their formation and dissolution. This physicochemical effect leads in vivo to the prevention of soft tissue calcification and, in some instances, inhibition of normal calcification. The main effect is to inhibit bone resorption, but in contrast to the effect on mineralisation, the mechanism involved is cellular. These various effects vary greatly according to the structure of the individual bisphosphonate. The half-life of circulating bisphosphonates is very brief, in the order of minutes to hours. 20% to 50% of a given dose is taken up by the skeleton, the rest being excreted in the urine. The half-life in bone is far longer and depends upon the turnover rate of the skeleton itself. Bisphosphonates are very well tolerated; the ...
Normophosphataemic familial tumoral calcinosis, charac-terized by ectopic mineralization of skin, is caused by mutations in the SAMD9 gene located in human chromosome 7q21, next to a paralogous gene, SAMD9-like (SAMD9L). The mouse does not have a SAMD9 orthologue, Samd9, because it has been deleted during evolution owing to genomic rearrangements. It has been suggested that the mouse Samd9l gene serves as a functional paralogue of human SAMD9. In this study, we examined Samd9l knockout mice with respect to ectopic mineralization. We also crossed these mice with Abcc6(tm1JfK) mice, a model system to study pseudoxanthoma elasticum, to see whether the absence of the Samd9l gene modifies the mineralization process. Necropsy analysis of Samd9l(tm1Homy) mice revealed no evidence of ectopic mineralization, and deletion of the Samd9l gene in mice failed to modify the mineralization process on the Abcc6(tm1JfK) background. Collectively, the results suggest that mouse Samd9l is not a functional paralogue of human
Read also: Study: Salt intake accelerates kidney scarring in CKD patients by activating brain-kidney connection. Blood vessel calcification may put people who develop recurrent kidney stones at increased risk of heart disease, according to a study appearing in an upcoming issue of the Clinical Journal of the American Society of Nephrology (CJASN). The findings suggest that monitoring such calcification may help protect stone formers heart health.. About 10% of men and 7% of women develop kidney stones. Over the last decade, large epidemiological studies have shown that kidney stone formers have an increased likelihood of developing other conditions such as hypertension, chronic kidney disease and heart disease; however, the mechanisms involved are unknown.. Linda Shavit, MD, from the University College London Medical School, in the UK, and Shaare Zedek Medical Center, in Israel, and her colleagues wondered whether the heart problems experienced by kidney stone formers might be due to abnormal ...
Tendon calcification in the shoulder joint. X-ray of a shoulder joint showing acute calcification in the subscapularis tendon. The bone on the left is the humerus, the rounded head of which articulates with the scapula on the right. The calcification is the small white area at the base of the articulation of these two bones. Calcification may occur due to damage to the tendon, and can make movement of the joint very painful and stiff (rheumatism). Treatment is by local corticosteroid injection which reduces inflammation, ultrasound application to disrupt the calcium deposit or, occasionally, surgical removal of the deposit. - Stock Image M110/0347
Medial vascular calcification (MVC) is a pathological condition common to a variety of diseases, including chronic kidney disease, diabetes, obesity, generalized arterial calcification of infancy, arterial calcification due to deficiency of CD73, and Keutel syndrome. These diseases share the common feature of tissue-nonspecific alkaline phosphatase (TNAP) upregulation in the vasculature. We developed a mouse model that overexpresses human TNAP in vascular smooth muscle cells, in an X-linked manner. As early as 7 days of age, mice showed strong TNAP expression in the aorta and, by 14 days, distinct aortic calcification was visible by X-ray. Hemizygous overexpressor male mice (TaglnCre/WT; HprtALPLflox/Y) exhibit severe cardiac hypertrophy and have a median age of death of 44 days, whereas the hypertrophy is less pronounced and life expectancy is normal in heterozygous females (TaglnCre/WT; HprtALPLflox/WT). Gene expression analysis showed upregulation of classical markers of MVC (Bmp2, Mgp and ...
Calciphylaxis is a rare and devastating disease, affecting mostly patients with end-stage kidney disease, but also affecting patients with preserved kidney function. Due to the low prevalence of the disease, high quality evidence for the evaluation and management of calciphylaxis is lacking. Most of the current evidence and recommendations are based on small studies, case reports, and expert opinion. In an article published in the July issue of AJKD, Nigwekar et al thoroughly review the current literature on calciphylaxis and provide a summary of recommendations to evaluate and manage patients with calciphylaxis, developed by the Massachusetts General Hospitals Multi-Disciplinary Calciphylaxis Team.. Clinically, calciphylaxis presents with severe painful skin lesions that are frequently complicated by blistering and ulcerations. Histologically, it is characterized by vascular and soft tissue calcification, intimal hypertrophy, and microthrombosis of small vessels, which result in necrotizing, ...
Between 1995 and 1997 our laboratory made a diagnosis of MAC by transthoracic echocardiography in 805 patients. Of these, 133 (73 women and 60 men; age range, 47 to 89 years; mean, 74.3±8 years) underwent carotid artery duplex ultrasound for various indications. This group was compared with 129 age- and sex-matched patients (72 women and 57 men; age range, 61 to 96 years; mean, 73.6±7 years) without MAC who underwent carotid artery duplex ultrasound during the same period. Patients with rheumatic valvular disease, cardiomyopathy, or prosthetic valves were excluded.. Complete 2-dimensional and Doppler color flow examinations were performed in all patients with the 2.5-MHz transducer of a Hewlett-Packard phased array sector scanner (model 77020 A). The 2-dimensional echocardiographic criteria for MAC included an intense echo-producing structure located at the junction of the atrioventricular groove and posterior mitral valve leaflet on the parasternal long axis and apical 4-chamber views or an ...
OBJECTIVE: To investigate the association between regular coffee consumption and the prevalence of coronary artery calcium (CAC) in a large sample of young and middle-aged asymptomatic men and women. METHODS: This cross-sectional study included 25 138 men and women (mean age 41.3 years) without clinically evident cardiovascular disease who underwent a health screening examination that included a validated food frequency questionnaire and a multidetector CT to determine CAC scores. We used robust Tobit regression analyses to estimate the CAC score ratios associated with different levels of coffee consumption compared with no coffee consumption and adjusted for potential confounders. RESULTS: The prevalence of detectable CAC (CAC score >0) was 13.4% (n=3364), including 11.3% prevalence for CAC scores 1-100 (n=2832), and 2.1% prevalence for CAC scores >100 (n=532). The mean +/-SD consumption of coffee was 1.8+/-1.5 cups/day. The multivariate-adjusted CAC score ratios (95% CIs) comparing coffee ...
Hamuro, Y, Acute changes in inorganic phosphorus, urea, and alkaline phosphatase of plasma and glomerular filtration rate during the development of soft tissue calcification in the kk mice fed a diet low in magnesium and high in phosphorus. (1971). Subject Strain Bibliography 1971. 269 ...
Involved primarily in ATP hydrolysis at the plasma membrane. Plays a role in regulating pyrophosphate levels, and functions in bone mineralization and soft tissue calcification. In vitro, has a broad specificity, hydrolyzing other nucleoside 5 triphosphates such as GTP, CTP, TTP and UTP to their corresponding monophosphates with release of pyrophosphate and diadenosine polyphosphates, and also 3,5-cAMP to AMP. May also be involved in the regulation of the availability of nucleotide sugars in the endoplasmic reticulum and Golgi, and the regulation of purinergic signaling. Appears to modulate insulin sensitivity ...
Two siblings with idiopathic infantile arterial calcification are reported. The fetal and postnatal echocardiographic features were a large pericardial effusion, thickened pulmonary and aortic valves, poor pulsation of the descending aorta, and calcification of the great vessels. In one patient calcification was first detected at 33 weeks gestation. Despite treatment with disodium etidronate both children died. ...
Calcium deposits in veins - What are calcium deposits in the urine? Sometimes the level. Of calcium in the urine or blood is so high that it precipitates and forms deposits in the kidney called nephrocalcinosis. The is related to, but not the same as kidney stones. It can be caused by several genetic syndromes, hyperparathyroidism and vitamin D toxicity, certain meds, TB, renal tubular acidosis, etc. It is usually managed by treated the underlying condition. Good wishes:)
Pseudoxanthoma elasticum (PXE) is a genetic disease considered as a paradigm of ectopic mineralization disorders, being characterized by multisystem clinical manifestations due to progressive calcification of skin, eyes, and the cardiovascular system, resembling an age-related phenotype. Although fibroblasts do not express the pathogenic ABCC6 gene, nevertheless these cells are still under investigation because they regulate connective tissue homeostasis, generating the arena where cells and extracellular matrix components can promote pathologic calcification and where activation of pro-osteogenic factors can be associated to pathways involving mitochondrial metabolism. The aim of the present study was to integrate structural and bioenergenetic features to deeply investigate mitochondria from control and from PXE fibroblasts cultured in standard conditions and to explore the role of mitochondria in the development of the PXE fibroblasts pathologic phenotype. Proteomic, biochemical, and ...
So far, despite the large list of widely known risk factors, in daily practice, there is a reduced list of modifiable factors that can be controlled adequately in patients with CKD. The final part of this article reviews some aspects that are related to possible interventions to reduce vascular calcifications. Some of them are available already, and others still are in the experimental area.. Because of the high prevalence of hyperphosphatemia in patients with CKD stage 5 (still approximately 40 to 70% in most large series) and the implications of high phosphate in vascular events and mortality and its implications in the pathogenesis of secondary hyperparathyroidism, most strategies have concentrated on the control of serum phosphorus. Despite great efforts, still poor results have been obtained to bring serum phosphorus to safe values in the majority of dialysis patients. In addition, few studies have demonstrated the benefits of reducing serum phosphorus on vascular calcifications and ...
The invention provides a standard component for calibration that enables a calibration position to be easily specified in order to calibrate accurately a scale factor in the electron-beam system, and provides an electron-beam system using it. High-accuracy metrology calibration capable of specifying a calibration position can be realized by forming a mark pattern or labeled material for identifying the calibration position in proximity of a superlattice pattern of the standard component for system calibration. The standard component for calibration is one that calibrates a scale factor of an electron-beam system based on a signal of secondary charged particles detected by irradiation of a primary electron beam emitted from the electron-beam system on a substrate having a cross section of a superlattice of a multi-layer structure in which different materials are deposited alternately. The substrate have linear patterns that are on the substrate surface parallel to the multi-layer and are arranged at a
Our findings indicate that neutrophil counts and (re)activity are not directly associated with silent CAD disease burden and as such are not suitable as biomarkers to predict the presence of subclinical CAD in a high-risk population of women with a history of preeclampsia.
with Wilfrid Sheldon: Sheldon, J. H.; Sheldon, W. (March 1936). "Arterial Calcification and Subcutaneous Calcinosis in a boy ... Arterial Calcification and Subcutaneous Calcinosis: Case shown in January, 1936". Proc R Soc Med. 31 (9): 1119-1120. doi: ... Sheldon, J. H. (April 1934). "Calcinosis Universalis". Proc R Soc Med. 27 (6): 623-626. doi:10.1177/003591573402700601. PMC ...
Enzootic Calcinosis Archived 2014-07-28 at the Wayback Machine Gruenberg MS, PhD, DECAR DECBHM. W.G., April 2014. Enzootic ... Calcinosis. The Merck Veternary Manual. Merck Sharp & Dohme, Whitehouse Station, NJ, USA. Topical Agents (Toxicity) Archived ...
TSC2 Tumoral calcinosis, familial, normophosphatemic; 610455; SAMD9 Tumoral calcinosis, hyperphosphatemic; 211900; KL Tumoral ... calcinosis, hyperphosphatemic, familial; 211900; FGF23 Tumoral calcinosis, hyperphosphatemic, familial; 211900; GALNT3 Tyrosine ...
"calcinosis_cutis_2_060122". Derm Atlas. Archived from the original on 5 February 2007. Retrieved 13 March 2012. "Calcium ...
Calcinosis cutis is condition in which there are irregular nodular deposits of calcium salts in skin and subcutaneous tissue. ... Calcinosis Monckeberg's arteriosclerosis "Cell Injury". CS1 maint: discouraged parameter (link) Bertazzo, Sergio; Gentleman, ...
... calcinosis (calcium deposits in blood vessels); atherosclerosis (blockage of blood vessels); type 2 diabetes; loss of bone mass ...
"Gastric mucosal calcinosis: clinicopathologic considerations" (PDF). Advances in Anatomic Pathology. 14 (3): 224-8. doi:10.1097 ... Drowsiness Headache Gastric mucosal calcinosis Heart valve calcification Hypercalcemia Increased intracranial pressure ...
Dystrophic calcinosis cutis has also been reported. Other serious sequelae include sialolithiasis of the submandibular gland ... Oga, A.; Kadowaki, T.; Hamanaka, S.; Sasaki, K. (1998). "Dystrophic calcinosis cutis in the skin below the mandible of a ...
Monckeberg's arteriosclerosis Pineal gland Calcinosis Bertazzo, Sergio; Gentleman, Eileen; Cloyd, Kristy L.; Chester, Adrian H ...
Dereure O (May 2007). "[SAMD9 mutation in normophosphatemic familial tumoral calcinosis]". Annales de Dermatologie et de ... "A deleterious mutation in SAMD9 causes normophosphatemic familial tumoral calcinosis". American Journal of Human Genetics. 79 ( ...
The compound 13-cis retinoic acid was first studied in the 1960s at Roche Laboratories in Switzerland by Werner Bollag as a treatment for skin cancer. Experiments completed in 1971 showed that the compound was likely to be ineffective for cancer and, surprisingly, that it could be useful to treat acne. However, they also showed that the compound was likely to cause birth defects, so in light of the events around thalidomide, Roche abandoned the product. In 1975, Gary Peck and Frank Yoder independently rediscovered the drug's use as a treatment of cystic acne while studying it as a treatment for lamellar ichthyosis, and published that work. Roche resumed work on the drug. In clinical trials, subjects were carefully screened to avoid including women who were or might become pregnant. Roche's New Drug Application for isotretinoin for the treatment of acne included data showing that the drug caused birth defects in rabbits. The FDA approved the application in 1982. Scientists involved in the ...
2007). "Tumoral calcinosis presenting with eyelid calcifications due to novel missense mutations in the glycosyl transferase ... 2006). "Polypeptide GalNAc-transferase T3 and familial tumoral calcinosis. Secretion of fibroblast growth factor 23 requires O- ... cause familial tumoral calcinosis". Nat Genet. 36 (6): 579-81. doi:10.1038/ng1358. PMID 15133511. "Entrez Gene: GALNT3 UDP-N- ... "Two novel nonsense mutations in GALNT3 gene are responsible for familial tumoral calcinosis". J. Hum. Genet. 52 (5): 464-8. doi ...
Lesions may also appear on the ear and eyelid.[citation needed] Ectopic calcification Calcinosis cutis Skin lesion List of ... Subepidermal calcified nodule is a type of Calcinosis cutis. It's a cutaneous condition characterized by calcification of the ...
Calcinosis Fahr's syndrome Muscular atrophy "OMIM Entry - # 259050 - PRIMROSE SYNDROME; PRIMS". omim.org. Retrieved 6 August ...
Bonazza S, La Morgia C, Martinelli P, Capellari S (August 2011). "Strio-pallido-dentate calcinosis: a diagnostic approach in ... Loeb JA (March 1998). "Functional improvement in a patient with cerebral calcinosis using a bisphosphonate". Mov. Disord. 13 (2 ...
Kalani, MY; Martirosyan, NL; Little, AS; Kakarla, UK; Theodore, N (Dec 2011). "Tumoral calcinosis presenting as a deformity of ...
Identification of Familial tumoral calcinosis (FTC) is an autosomal recessive disorder characterized by ectopic calcifications ... "An FGF23 missense mutation causes familial tumoral calcinosis with hyperphosphatemia". Human Molecular Genetics. 14 (3): 385- ...
Some children develop calcinosis, which are calcium deposits under the skin. The rash is the source of the "dermato-" part of ... calcinosis and neopterin. Once a diagnosis of JDMS is made, the treatment is often a 3-day course of Intravenous ("pulse") ... calcinosis, dysphonia and nailfold capillaroscopy. Other useful criteria include myositis-specific or -related antibodies, ...
2000). Enzootic calcinosis in 16 cows from 6 dairy farms in Unterengadin. Schweiz Arch Tierheilkd. 142:6 333-8. Braun, U., et ... 2000). Enzootic calcinosis in goats caused by golden oat grass (Trisetum flavescens). Veterinary Record 146 161-2. Grabner, A ... 1985). Enzootic calcinosis in the horse. Tierarztl Prax Suppl. 1 84-93. Ess. Agrostogr. 88, 153. 1812 GrassBase entry: Trisetum ... This grass is noted for being toxic to livestock, causing calcinosis, the deposition of calcium in soft tissues including ...
Excretory calcinosis in American lobsters in Long Island Sound was described in 2002. The disease causes mineralized calculi to ... A. D. Dove; C. LoBue; P. Bowser; M. Powell (2004). "Excretory calcinosis: a new fatal disease of wild American lobsters Homarus ... A. D. M. Dove (2005). "Ultrastructural features of excretory calcinosis in the lobster, Homarus americanus Milne-Edwards". ...
... may be a result of CREST syndrome, referring to the five main features: calcinosis, Raynaud ... and subcutaneous calcinosis: a syndrome mimicking hereditary hemorrhagic telangiectasia". Bulletin of the Johns Hopkins ...
CREST causes thickening and tightening of the skin with deposition of calcific nodules ("calcinosis"). Raynaud's phenomenon is ... The acronym "CREST" refers to the five main features: calcinosis, Raynaud's phenomenon, esophageal dysmotility, sclerodactyly, ... Winterbauer RH (1964). "Multiple telangiectasia, Raynaud's phenomenon, sclerodactyly, and subcutanious calcinosis: a syndrome ...
Calcinosis cutis Skin lesion List of cutaneous conditions "OMIM Entry - # 166350 - OSSEOUS HETEROPLASIA, PROGRESSIVE; POH". ...
Calcinosis (deposition of calcium in lumps under the skin) is also common in systemic scleroderma, and is often seen near the ... Joint mobility, especially of the small joints of the hand, may be restricted by calcinosis or skin thickening. Patients may ... Calcinosis, Raynaud's phenomenon, Esophageal dysfunction, Sclerodactyly, and Telangiectasia (CREST syndrome) are associated ...
Gorospe M, Fadare O (May 2007). "Gastric mucosal calcinosis: clinicopathologic considerations". Advances in Anatomic Pathology ...
Typical clinical features include jaundice, elevated blood levels of alkaline phosphatase, calcinosis cutis, telangiectasias, ...
This plant is common to South American countries, where calcinosis, including tissue calcification, and associated pathology, ... "Hypercalcemia and calcinosis in Florida horses: implication of the shrub, Cestrum diurnum, as the causative agent". The Cornell ...
The syndrome recognises the significantly co-presenting symptoms of calcinosis, Raynaud's phenomenon, esophageal dysmotility, ...
Calcinosis is the formation of calcium deposits in any soft tissue. It is a rare condition that has many different causes. ... The most common type of calcinosis is dystrophic calcification. This type of calcification can occur as a response to any soft ... The cause of the rare condition of tumoral calcinosis is not entirely understood. It is generally characterized by large, ... Calcification Calcinosis cutis Dermatomyositis Fahrs syndrome Hyperphosphatemia Primrose syndrome Scleroderma Media related to ...
... indicating an evolutionary conserved mechanism that is involved in developing tumoral calcinosis. The name indicates calcinosis ... Tumoral calcinosis is a rare condition in which there is calcium deposition in the soft tissue in periarticular location, ... Clinically also known as hyperphosphatemic familial tumoral calcinosis (HFTC), is often caused by genetic mutations in genes ... Genetests/NCBI/NIH/UW entries on Hyperphosphatemic Familial Tumoral Calcinosis. ...
... calcinosis) in the bodys tissues. Explore symptoms, inheritance, genetics of this condition. ... Hyperphosphatemic familial tumoral calcinosis (HFTC) is a condition characterized by an increase in the levels of phosphate in ... Calcinosis may also develop in the soft tissue of the feet, legs, and hands. Rarely, calcinosis occurs in blood vessels or in ... Genetic Testing Registry: Hyperphosphatemic familial tumoral calcinosis 3 *Genetic Testing Registry: TUMORAL CALCINOSIS, ...
Calcinosis cutis is a term used to describe a group of disorders in which calcium deposits form in the skin. Virchow initially ... encoded search term (Calcinosis Cutis) and Calcinosis Cutis What to Read Next on Medscape ... Calcinosis Cutis Differential Diagnoses. Updated: Mar 05, 2020 * Author: Julia R Nunley, MD; Chief Editor: Dirk M Elston, MD ... Calcinosis cutis: an additional therapy to consider. J Am Acad Dermatol. 2012 Jun. 66(6):1004-5; author reply 1005. [Medline]. ...
calcinosis synonyms, calcinosis pronunciation, calcinosis translation, English dictionary definition of calcinosis. n. An ... Related to calcinosis: calcinosis circumscripta, Calcinosis cutis, tumoral calcinosis. cal·ci·no·sis. (kăl′sə-nō′sĭs). n.. An ... calcinosis. n calcinosis f. English-Spanish/Spanish-English Medical Dictionary Copyright © 2006 by The McGraw-Hill Companies, ... Tumoral calcinosis in infants: a report of three cases and review of the literature.. Selim kalsinozis kutis/Benign calcinosis ...
Based upon the etiology of calcium deposition, there are five subtypes of calcinosis cutis: dystrophic, metastatic, idiopat ... Calcinosis cutis is a descriptive term for the deposition of insoluble calcium salts in the cutaneous and subcutaneous tissue. ... Idiopathic calcinosis cutis: Idiopathic calcinosis cutis is the occurrence of calcinosis cutis without any underlying tissue ... Iatrogenic calcinosis cutis: Iatrogenic calcinosis cutis is the deposition of calcium salts in the skin as a side effect of ...
Idiopathic Scrotal Calcinosis. *Occurs in two settings: *Calcification of a preexisting epidermal inclusion cyst (EIC) or pilar ...
... By Stephanie Eschenbach, MD and Thomas L. Pope, Jr., MD, FACR ... 2 Subcutaneous calcinosis, as part of the CREST variant or diffuse variant, is often seen on the extensor surfaces and in areas ... subcutaneous calcinosis on the left thumb volar pad; 5) moderate-to-severe resorption of the right first-, second-, and third- ... "7 The combination of calcinosis and acro-osteolysis, as seen in Figure 2, is considered to be pathognomic for scleroderma.6 ...
We present what we believe is the first identified case of autoimmune hyperphosphatemic tumoral calcinosis in an 8-year-old boy ... Hyperphosphatemic familial tumoral calcinosis (HFTC)/hyperostosis-hyperphosphatemia syndrome (HHS) is an autosomal recessive ... In addition to the classical clinical and biochemical features of hyperphosphatemic tumoral calcinosis, the patient exhibited ... Thus, this report describes the first case, to our knowledge, of autoimmune hyperphosphatemic tumoral calcinosis with ...
Evaluation of Calcinosis Prevalence in Systemic Sclerosis : a Cross Sectional Study Evaluating Calcinosis Cutis Prevalence by ... Evaluation of Calcinosis in Systemic Sclerosis (CALCIDERMIS). The safety and scientific validity of this study is the ... Calcinosis cutis prevalence by radiographic assessment [ Time Frame: at inclusion ( baseline) ]. Secondary Outcome Measures : * ... Calcinosis. Pathologic Processes. Connective Tissue Diseases. Skin Diseases. Calcium Metabolism Disorders. Metabolic Diseases. ...
Bilateral striopallidodentate calcinosis. Disease definition Bilateral striopallidodentate calcinosis (BSPDC, also erroneously ...
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... primary hyperphosphatemic tumoral calcinosis; tumoral calcinosis with hyperphosphatemia ... Synonyms: cortical hyperostosis with hyperphosphatemia; familial hyperphosphatemic tumoral calcinosis/hyperphosphatemic ... hyperostosis syndrome; familial Teutschlaender disease; HFTC; HHS; hypercalcemic tumoral calcinosis; hyperostosis with ... tumoral calcinosis with hyperphosphatemia Alt IDs: OMIM:211900, ICD10CM:M11.2, ORDO:306661 Definition: A calcinosis ...
V. Mehta and C. Balachandran, "Idiopathic vulvar calcinosis: the counterpart of idiopathic scrotal calcinosis," Indian Journal ... Scrotal Calcinosis: A Case Report and Review of Pathogenesis and Surgical Management. Usman M. Tela1 and M. Bashir Ibrahim2 ... S. G. Browne, "Calcinosis circumscripta of the scrotal wall, the aetiologic role of onchocerca vulvulus," British Journal of ... C. H. Chang, C. H. Yang, and H. S. Hong, "Surgical pearl: pinch-punch excisions for scrotal calcinosis," Journal of the ...
... calcinosis) on a dime. The calcinosis was removed from a patient who has had systemic sclerosis (scleroderma) for a year. ISN ... Also see Photo of Calcinosis on Fingertip). A year and a half ago, her doctor stopped her Raynauds medication for emotional ... Photo of Calcinosis on Dime. Author: Shelley Ensz. Scleroderma is highly variable. See Types of Scleroderma. Read Disclaimer ... The calcium nodule (calcinosis) is an ugly thing, with lots of irregularities to hang onto flesh. My wife has had scleroderma ...
The Mammalian Phenotype (MP) Ontology is a community effort to provide standard terms for annotating phenotypic data. You can use this browser to view terms, definitions, and term relationships in a hierarchical display. Links to summary annotated phenotype data at MGI are provided in Term Detail reports.
Calcinosis circumscripta is deposition of calcium at bony prominences or, in the footpads and mouth. It is usually a disease of ... Calcinosis cutis is induced by local skin damage in susceptible animals and takes two forms: dystrophic or metastatic. The ... How does calcinosis cutis and calcinosis circumscripta typically progress?. In the case of calcinosis circumscripta, single ... Calcinosis cutis occurs in susceptible pets in areas where local skin damage has occurred. Calcinosis cutis has two forms:. * ...
CALCINOSIS TREATED BY PARATHYROIDECTOMY1 ELMER C. BARTELS, M.D., F.A.C.P.; RICHARD B. CATTELL, M.D. ... CALCINOSIS AND SCLERODERMA WITH PARATHYROIDECTOMY1 Annals of Internal Medicine; 18 (2): 225-232 ... Subcutaneous calcinosis, a disease tending to serious bodily disability, presents a most difficult therapeutic problem. It is ... Dystrophic calcinosis in a patient with overlap syndrome (scleroderma and rheumatoid arthritis) treated by leflunomide: A case ...
Skin calcinosis pathology, Cutaneous calcification pathology. Authoritative facts from DermNet New Zealand. ... Histology of calcinosis cutis. There are irregular deposits of intensely basophilic acellular material in the dermis and ... The deposition of calcium in the skin, subcutaneous tissue, muscles and visceral organs is known as calcinosis. This condition ... Calcinosis cutis pathology. Author: Dr Ben Tallon, Dermatologist/Dermatopathologist, Tauranga, New Zealand, December 2016. ...
... Subscriber Sign In VisualDx Mobile Feedback Select Language Share Get VisualDx Mobile. There are VisualDx ... L94.2 - Calcinosis cutis. SNOMEDCT:. 21323007 - Calcinosis cutis. Look For. Subscription Required. Diagnostic Pearls. ... Calcinosis cutis in Infant/Neonate. Print Images (7) Contributors: Noah Craft MD, PhD, Belinda Tan MD, PhD, Lowell A. Goldsmith ... Note, however, that calcinosis cutis can occur anywhere on the body. Local trauma, infections (particularly parasitic, eg, ...
... index finger on knuckle which has lead to a calcinosis, (same finger), which has become abscessed on pad, its becoming bigger. ... Not sure what hurts more the ulcer or the calcinosis! :wacko: Well..... even if I slightly bump the calcinosis, or touch it, it ... Ulcer and Calcinosis By Annie20, June 8, 2011. in Sclero Forums (MAIN) ... If I bump or press on the calcinosis, it hurts tremendously. (It has become bigger.) I do not want to subject myself to anymore ...
Pronounced Linear Calcinosis in a Boy with Mild Dermatomyositis del Carmen Boente, María; Nadra, Graciela; Asial, Raúl et al. ... Calcinosis in Ruminants due to Plant Poisoning: Contributions on the Pathogenesis Acamovic, T.; Stewart, C. S.; Pennycott, T. ... Tumoral Calcinosis and Calciphylaxis After Renal Transplantation Fernandez, E.; Torregrosa, J. V.; Zarraga, S. et al. 1998-01- ... Tumoral Calcinosis Associated With End-Stage Renal Disease: A Case Study Capes, M.; Fox, R. B.; Association of Chiropractic ...
... defined as calcinosis involving the torso or 2 extremities) and moderate to severe calcinosis (indicated by a calcinosis ... Calcinosis can be painful and cause disabilities and other problems. Researchers want to learn more about calcinosis to find ... Has moderate to severe calcinosis, defined as having a calcinosis activity visual analogue scale score of greater than or equal ... Improvement of calcinosis lesions, assessed by Calcinosis Assessment Tool, durometry measurements, photography, and imaging ...
Learn about the veterinary topic of Enzootic Calcinosis in Animals. Find specific details on this topic and related topics from ... Etiology and Pathogenesis of Enzootic Calcinosis in Animals Known causes of enzootic calcinosis fall into two categories: plant ... Clinical Findings of Enzootic Calcinosis in Animals Enzootic calcinosis is progressive and chronic, extending for weeks or ... Diagnosis of Enzootic Calcinosis in Animals * Presumptive diagnosis is based on history and clinical signs ...
Calcium and Phosphate Metabolism in Tumoral Calcinosis PAUL D. MITNICK, M.D.; STANLEY GOLDFARB, M.D.; EDUARDO SLATOPOLSKY, M.D ... Calcium and Phosphate Metabolism in Tumoral Calcinosis. Ann Intern Med. 1980;92:482-487. doi: 10.7326/0003-4819-92-4-482 ... We have recently seen a patient with tumoral calcinosis, a syndrome comprising hyperphosphatemia, normocalcemia, normal ...
Treating calcinosis cutis via a topical wash with DMSO every other day was effective for the symptoms of calcinosis cutis. ... A dog with calcinosis cutis was treated by topical dimethyl sulfoxide (DMSO) administration, reaching a complete involution of ... For this reason, DMSO is proposed as a topical treatment for the management of calcinosis cutis in dogs. The authors present ... Resolution of iatrogenic calcinosis cutis in a dog through topical application of DMSO. 26 Sep 2018 ...
Find out information about Calcinosis. Deposition of calcium salts in the skin, subcutaneous tissue, or other part of the body ... Related to Calcinosis: calcinosis circumscripta, Calcinosis cutis, tumoral calcinosis. calcinosis. [‚kal·sə′nō·səs] (medicine) ... Cutaneous calcinosis or Calcinosis cutis is a skin disease of dogs characterized by dystrophic calcium deposition in dermis and ... La radiografia confirmo la sospecha de extensas areas de calcinosis (Figura 1).. Calcinosis asimetrica en un adulto con ...
What is tumoral calcinosis? Meaning of tumoral calcinosis medical term. What does tumoral calcinosis mean? ... Looking for online definition of tumoral calcinosis in the Medical Dictionary? tumoral calcinosis explanation free. ... 2. calcinosis that develops in association with neoplastic conditions. tumoral calcinosis. Oncology A condition characterized ... Spontaneous regression of multiple tumoral calcinosis in a child.. Selim kalsinozis kutis/Benign calcinosis cutis ...
As expected given the plain film appearances, there are multiple low-T2 lesions anterior to the patella consistent with multifocal calcification or ossification. ...
"Calcinosis" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... This graph shows the total number of publications written about "Calcinosis" by people in this website by year, and whether " ... Below are the most recent publications written about "Calcinosis" by people in Profiles. ...
  • Hyperphosphatemic familial tumoral calcinosis (HFTC) is a condition characterized by an increase in the levels of phosphate in the blood (hyperphosphatemia) and abnormal deposits of phosphate and calcium (calcinosis) in the body's tissues. (medlineplus.gov)
  • Hyperphosphatemic familial tumoral calcinosis (HFTC) is a very rare disorder of phosphate homeostasis resulting from decreased fibroblast growth factor 23 (FGF23) synthesis or activity (1). (thefreedictionary.com)
  • To the Editor: Primary familial brain calcification (PFBC) is a rare genetically degenerative disease that is generally characterized by symmetrical, bilateral calcinosis in the basal ganglia, thalamus, dentate nuclei, and other brain regions and mainly manifests with neurological and psychiatric symptoms. (thefreedictionary.com)
  • Hyperphosphatemic familial tumoral calcinosis (HFTC)/hyperostosis-hyperphosphatemia syndrome (HHS) is an autosomal recessive disorder of ectopic calcification due to deficiency of or resistance to intact fibroblast growth factor 23 (iFGF23). (jci.org)
  • Histologically, lesions display collagen necrobiosis, followed by cyst formation and a foreign-body response with calcification Two forms of tumoral calcinosis have been described: normocalcemic tumoral calcinosis and familial tumoral calcinosis. (nih.gov)
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Familial tumoral calcinosis. (nih.gov)
  • Hyperphosphatemic Familial Tumoral Calcinosis, Fgf23-Related An important gene associated with Hyperphosphatemic Familial Tumoral Calcinosis, Fgf23-Related is FGF23 (Fibroblast Growth Factor 23). (malacards.org)
  • There are three types: familial tumoral calcinosis, subepidermal calcified nodules, and scrotal calcinosis. (statpearls.com)
  • Familial tumoral calcinosis is seen in healthy adolescent patients. (statpearls.com)
  • 76 Tumoral calcinosis, normophosphatemic, familial: An uncommon, life-threatening disorder characterized by progressive deposition of calcified masses in cutaneous and subcutaneous tissues. (malacards.org)
  • An important gene associated with Tumoral Calcinosis, Normophosphatemic, Familial is SAMD9 (Sterile Alpha Motif Domain Containing 9), and among its related pathways/superpathways are Spinal Cord Injury and Glucocorticoid receptor regulatory network . (malacards.org)
  • 77 Normophosphatemic familial tumoral calcinosis is a cutaneous disorder characterized by cutaneous. (malacards.org)
  • Adams WM et al: Familial tumoral calcinosis: association with cerebral and peripheral aneurysm formation. (statdx.com)
  • Slavin RE et al: Familial tumoral calcinosis. (statdx.com)
  • Hyperphosphatemic Familial Tumoral Calcinosis (HFTC) and Hyperphosphatemic Hyperostosis Syndrome (HHS) are associated with autosomal recessive mutations in three different genes, FGF23 , GALNT3 and KL , leading to reduced levels of fibroblast growth factor 23 (FGF23) and subsequent clinical effects. (biomedcentral.com)
  • Hyperphosphatemic familial tumoral calcinosis (HFTC) is a rare monogenic disorder with disturbances in the hormonal regulation of phosphate levels by FGF23, leading to soft tissue calcifications [ 2 ]. (biomedcentral.com)
  • At least 25 mutations in the GALNT3 gene have been found to cause hyperphosphatemic familial tumoral calcinosis (HFTC), a condition characterized by an increase in the levels of phosphate in the blood (hyperphosphatemia) and abnormal deposits of phosphate and calcium (calcinosis) in the body's tissues. (nih.gov)
  • Chefetz I, Kohno K, Izumi H, Uitto J, Richard G, Sprecher E. GALNT3, a gene associated with hyperphosphatemic familial tumoral calcinosis, is transcriptionally regulated by extracellular phosphate and modulates matrix metalloproteinase activity. (nih.gov)
  • Chefetz I, Sprecher E. Familial tumoral calcinosis and the role of O-glycosylation in the maintenance of phosphate homeostasis. (nih.gov)
  • Hyperphosphatemic familial tumoral calcinosis (FGF23, GALNT3 and αKlotho). (nih.gov)
  • Clinical variability of familial tumoral calcinosis caused by novel GALNT3 mutations. (nih.gov)
  • Sprecher E. Familial tumoral calcinosis: from characterization of a rare phenotype to the pathogenesis of ectopic calcification. (nih.gov)
  • The most common type of calcinosis is dystrophic calcification. (wikipedia.org)
  • Enzootic calcinosis is a disease complex of ruminants and horses caused by plant poisoning or mineral imbalances and characterized by extensive calcification of soft tissues. (merckvetmanual.com)
  • Tumoral calcinosis may be defined as metastatic periarticular calcification that can be found in a wide variety of conditions such as primary hyperthyroidism and connective tissue diseases, as well as an idiopathic form. (thefreedictionary.com)
  • Some patients with ACTD may experience calcinosis universalis with widespread calcification of the subcutaneous tissue, muscles, and tendons. (clinicaladvisor.com)
  • Dystrophic calcification is the most common cause of calcinosis cutis and is associated with normal laboratory values of calcium and phosphorus. (statpearls.com)
  • NFTC shows a striking resemblance to acquired dystrophic calcinosis, in which tissue calcification occurs as a consequence of tissue injury/inflammation. (malacards.org)
  • Idiopathic calcification does not involve underlying tissue damage or abnormal laboratory values and includes tumoral calcinosis, subepidermal calcified nodules, and scrotal calcinosis. (statpearls.com)
  • Calcinosis cutis-calcification in soft tissue-is a rare benign disease that is separated into the following subtypes: dystrophic, iatrogenic, metastatic, calciphylaxis, and idiopathic. (kjuo.or.kr)
  • The feature of calcinosis cutis of the scrotum is generally slowly growing yellowish nodules that consist of calcification with surrounding foreign body-type granulomatous inflammation. (kjuo.or.kr)
  • Plain radiography revealed calcinosis universalis in abdomen ( Fig. 1 ), pelvis and thighs, with intramuscular calcification proximal to the distal insertion of vastus medialis ( Fig. 2 ) and generalized osteopenia. (reumatologiaclinica.org)
  • Calcinosis in thighs with intramuscular calcification proximal to the distal insertion of the vastus medialis. (reumatologiaclinica.org)
  • S. G. Browne, "Calcinosis circumscripta of the scrotal wall, the aetiologic role of onchocerca vulvulus," British Journal of Dermatology , vol. 74, pp. 136-140, 1962. (hindawi.com)
  • Calcinosis circumscripta is the deposition of calcium usually at bony prominences (i.e., where bone and skin are thinly separated) or in the footpads and mouth. (vcahospitals.com)
  • The cause of calcinosis circumscripta is unknown, but there seems to be a genetic or hereditary component. (vcahospitals.com)
  • Pets with calcinosis circumscripta usually have a single lesion over a bony prominence or in the mouth, particularly the tongue. (vcahospitals.com)
  • How does calcinosis cutis and calcinosis circumscripta typically progress? (vcahospitals.com)
  • In the case of calcinosis circumscripta , single lesions due to causes such as trauma can be cured surgically. (vcahospitals.com)
  • Recurrence of calcinosis circumscripta after surgery does not tend to occur. (vcahospitals.com)
  • characteristic of calcinosis circumscripta. (learningradiology.com)
  • The lesion was successfully excised, and histopathology was performed, revealing evidence of both multiple cartilaginous exostoses and calcinosis circumscripta. (ovid.com)
  • Additionally, multiple cartilaginous exostoses have not previously been reported to occur in combination with calcinosis circumscripta. (ovid.com)
  • The disorder is classified as calcinosis circumscripta if it is limited to an extremity or joint. (statpearls.com)
  • Calcinosis cutis circumscripta: treatment with intralesional corticosteroid. (puppy-party.info)
  • Deposits elsewhere in the body are known as calcinosis circumscripta. (dailypuppy.com)
  • Internal calcinosis circumscripta is diagnosed via X-ray or computed tomography. (dailypuppy.com)
  • Calcinosis circumscripta most often affects young large-breed dogs. (dailypuppy.com)
  • While calcinosis cutis initially looks like calcinosis circumscripta, it appears on older dogs. (dailypuppy.com)
  • Treatment for calcinosis circumscripta consists primarily of surgical removal of the growths. (dailypuppy.com)
  • There's good news -- once an affected dog reaches the age of two, he's unlikely to develop new calcinosis circumscripta lumps. (dailypuppy.com)
  • Calcinosis cutis complicating adult-onset dermatomyositis. (medscape.com)
  • Calcinosis cutis universalis with joint contractures complicating juvenile dermatomyositis. (medscape.com)
  • Valenzuela A, Chung L, Casciola-Rosen L, Fiorentino D. Identification of clinical features and autoantibodies associated with calcinosis in dermatomyositis. (medscape.com)
  • Localized calcinosis in juvenile dermatomyositis: Successful treatment with intralesional corticosteroids injection. (thefreedictionary.com)
  • Calcinosis, a serious complication of dermatomyositis, involves deposition of calcium (carbonate apatite) in soft tissue, and can result in negative impacts on quality of life and physical function. (centerwatch.com)
  • To date, there are no known effective therapies that are approved for the treatment of dermatomyositis-associated calcinosis, and there is no consensus within the medical community on the optimum treatment strategy for this often-debilitating condition. (centerwatch.com)
  • In order to gather more robust data on the utility of this medication in the treatment of calcinosis associated with adult and juvenile dermatomyositis, we propose to evaluate its effects in the context of a prospective clinical trial. (centerwatch.com)
  • We plan to enroll participants at a single center into a single-arm, open-label study, with the overall objective of evaluating the efficacy and safety of intravenous sodium thiosulfate use in patients with moderate to severe extensive calcinosis associated with juvenile and adult dermatomyositis. (centerwatch.com)
  • Treatment of calcinosis in juvenile dermatomyositis with probenecid: the role of phosphorus metabolism in the development of calcifications. (jrheum.org)
  • OBJECTIVE: To report the efficacy of probenecid for calcinosis of juvenile dermatomyositis (JDM) and assess the changes in phosphorus metabolism during treatment. (jrheum.org)
  • Calcinosis cutis is seen in 30% of adults and up to 70% of children and adolescents with dermatomyositis. (statpearls.com)
  • People with connective tissue diseases such as systemic scleroderma , dermatomyositis and cutaneous lupus erythematosus may also develop calcinosis. (sclerodermanews.com)
  • There is calcinosis cutis from prednisone a length significant prednisone therapy in akathisia grade that is modified by younger email at vanishedi and dermatomyositis strength. (auto-uitlaat.be)
  • We report a 14-year-old girl with juvenile dermatomyositis (JDM) complicated by severe inflammatory calcinosis successfully treated with thalidomide. (biomedcentral.com)
  • We report a 26-year-old woman with severe calcinosis associated with dermatomyositis. (elsevier.com)
  • Although calcinosis of the skin or muscles is unusual in adults with dermatomyositis, this patient developed subcutaneous calcinosis with tenderness on the arms, axillary areas, shoulder areas, chest, abdomen, pelvis, and limbs. (elsevier.com)
  • Based upon the etiology of calcium deposition, there are five subtypes of calcinosis cutis: dystrophic, metastatic, idiopathic, iatrogenic, and calciphylaxis ( table 1 ). (uptodate.com)
  • Metastatic calcinosis cutis results from abnormal calcium or phosphate metabolism, leading to the precipitation of calcium in skin and subcutaneous tissue. (uptodate.com)
  • In dogs, the most common cause of metastatic calcinosis cutis is the overproduction of corticosteroids, a type of hormone produced by the adrenal glands. (vcahospitals.com)
  • A less common cause of metastatic calcinosis cutis in dogs is corticosteroid ('steroid') treatment for extended periods of time (e.g., for allergies). (vcahospitals.com)
  • Other, more rare, causes of metastatic calcinosis cutis include kidney disease (the most common cause in cats), diabetes mellitus, lung disease, and malignant tumors that produce abnormal hormones that increase blood calcium concentrations (including cancer of the anal glands and cancer of the lymphoid system). (vcahospitals.com)
  • Calcinosis cutis is classified as dystrophic, metastatic, iatrogenic, or idiopathic based on these causative agents. (clinicaladvisor.com)
  • Metastatic calcinosis cutis presents with altered calcium and phosphorus metabolism, typically in the setting of chronic renal disease. (clinicaladvisor.com)
  • Metastatic calcinosis cutis may involve visceral calcifications as well as potentially generalized dermal or symmetrical periarticular distribution. (clinicaladvisor.com)
  • Given the connection between metastatic calcinosis cutis and disorders of calcium and phosphorus metabolism, assessing serum calcium, phosphorus, and parathyroid hormone levels as well as a urine analysis, are crucial. (clinicaladvisor.com)
  • More detailed information about the symptoms , causes , and treatments of Metastatic calcinosis cutis is available below. (rightdiagnosis.com)
  • CT scan however demonstrates these calcifications in many more conditions like hamartoma (2) , chondroma (3) , carcinoid (4) , lung carcinoma (5) , metastatic calcifications following cardiac surgery in children (6) , calcinosis following liver transplant (7) , pulmonary alveolar microlithiasis (8) , Amiodarone pulmonary toxicity (9) to name a few. (ijars.net)
  • Interestingly, a zebrafish animal model with reduced GALNT3 expression also showed HFTC-like phenotype, indicating an evolutionary conserved mechanism that is involved in developing tumoral calcinosis. (wikipedia.org)
  • Tristano AG, Villarroel JL, Rodriguez MA, Millan A. Calcinosis cutis universalis in a patient with systemic lupus erythematosus. (medscape.com)
  • Calcinosis universalis occurs when there is diffuse involvement of subcutaneous and fibrous structures of muscles and tendons. (statpearls.com)
  • Calcinosis universalis in abdomen and pelvis. (reumatologiaclinica.org)
  • Please cite this article as: Novella Navarro M, Muñoz Gómez MM, Salvatierra Ossorio J. Calcinosis universalis en paciente con dermatomiositis. (reumatologiaclinica.org)
  • Miteva L, Pramatarov K, Vassileva S. Calcinosis cutis in childhood systemic lupus erythematosus. (medscape.com)
  • Extensive calcinosis cutis with systemic lupus erythematosus. (medscape.com)
  • Bullous systemic lupus erythematosus with milia and calcinosis. (medscape.com)
  • The aim of the study is firstly to determine prevalence of calcinosis cutis, with hand and feet radiography realisation in a cohort of systemic sclerosis patient. (clinicaltrials.gov)
  • Jeziorska, "Expression of advanced glycation end products and their receptor in skin from patients with systemic sclerosis with and without calcinosis ," Rheumatology, vol. (thefreedictionary.com)
  • Calcinosis cutis is associated with systemic sclerosis. (statpearls.com)
  • Calcinosis cutis commonly occurs in patients with systemic sclerosis, especially the limited form (CREST). (statpearls.com)
  • Twenty-five percent to 40% of patients with limited systemic sclerosis will develop calcinosis cutis ten years after the onset of disease. (statpearls.com)
  • An year-old woman was followed up for a year history of limited cutaneous systemic sclerosis complicated by recurrent subcutaneous lesions of calcinosis. (puppy-party.info)
  • Calcinosis cutis often occurs along with systemic sclerosis scleroderma. (puppy-party.info)
  • Al-Khudairi N et al: A case of symptomatic cervical spine calcinosis in systemic sclerosis. (statdx.com)
  • Sambataro D et al: Tumoral calcinosis of the spine in the course of systemic sclerosis: report of a new case and review of the literature. (statdx.com)
  • Identify the features of calcinosis cutis and of associated systemic diseases. (statpearls.com)
  • Association of TNFSF4 (OX40L) polymorphisms with systemic sclerosis-related calcinosis. (cdc.gov)
  • A Case of Primary Hyperparathyroidism Associated with Hypercalcemic Crisis and Systemic Calcinosis. (e-enm.org)
  • Nephrocarcinosis and cutaneous cacifications have been recognized in patients with chronic renal failure, but the hypercalcemic crisis and systemic calcinosis are extremely rare in patients with primary hyperparathyroidism. (e-enm.org)
  • M. Dini and M. Colafranceschi, "Should scrotal calcinosis still be termed idiopathic? (hindawi.com)
  • A. G. Saad and G. S. Zaatari, "Scrotal calcinosis: is it idiopathic? (hindawi.com)
  • J. M. Swinehart and L. E. Golitz, "Scrotal calcinosis. (hindawi.com)
  • U. H. G. Michl, A. J. Gross, V. Loy, and K. P. Dieckmann, "Idiopathic calcinosis of the scrotum-a specific entity of the scrotal skin. (hindawi.com)
  • Scrotal calcinosis has traditionally been classified as a type of idiopathic calcinosis cutis that presents as multiple, firm nodules on the scrotum. (clinicaladvisor.com)
  • This association raises the question as to whether scrotal calcinosis would be more appropriately classified as a type of dystrophic calcinosis cutis. (clinicaladvisor.com)
  • Idiopathic scrotal calcinosis is a rare benign disease which presents with multiple asymptomatic various sized nodules on the scrotal skin wall. (alliedacademies.org)
  • It includes tumoral calcinosis, subepidermal calcified nodules, and scrotal calcinosis. (statpearls.com)
  • Idiopathic calcinosis cutis of the scrotum (ICCS), also called idiopathic scrotal calcinosis, is an uncommon entity and was first described by Lewinski in 1883 [ 2 ]. (biomedcentral.com)
  • In recent times, there has been a debate on the pathogenesis of scrotal calcinosis, with questions being raised on its idiopathic nature [ 3 , 4 ]. (biomedcentral.com)
  • Idiopathic Scrotal Calcinosis is a skin condition that I occasionally encounter in both my The Woodlands dermatology and Conroe dermatology offices. (perridermatology.com)
  • Idiopathic calcinosis cutis of the scrotum is one diagnosis of a scrotal mass. (kjuo.or.kr)
  • 2 established idiopathic scrotal calcinosis as a distinct entity in 1970, several cases had been reported worldwide. (kjuo.or.kr)
  • Thus, we present a case of a 35-year-old male patient with massive idiopathic scrotal calcinosis. (kjuo.or.kr)
  • Deposition of insoluble calcium salts in the tissue, cutaneous calcinosis (CC), can be caused by various diseases. (thefreedictionary.com)
  • Among the cutaneous features (Table 1), fingertip ulceration was found in 36 (66.7%), sclerodactyly in 48 (88.8%) (Figure 1), digital pitted scars in 30 (55.5%) (Figure 2), digital gangrene in 3 (5.6%), calcinosis cutis in 4 (7.4%), microstomia in 48 (88.8%) (Figure 3), radial furrows around mouth in 18 (33.3%) (Figure 4), pinched nose in 33 (61.1%), diffuse alopecia in 10 (18.5%) and nail changes in 10 (18.5%) cases. (thefreedictionary.com)
  • Calcinosis cutis is a descriptive term for the deposition of insoluble calcium salts in the cutaneous and subcutaneous tissue. (uptodate.com)
  • A calcinosis characterized by autosomal recessive inheritance of elevated blood calcium levels and calcium phosphate crystals in cutaneous and subcutaneous tissues that has_material_basis_in mutation in the GALNT3 gene, the FGF23 gene, or the KL gene. (jax.org)
  • We describe a case of PSC occurring in a patient with CREST (calcinosis cutis, Raynaud phenomenon, esophageal dysmotility, sclerodactyly and telangiectasia) syndrome, which is a type of limited cutaneous scleroderma. (biomedcentral.com)
  • As cutaneous manifestations, aside from lesions compatible with Gottron's papules on upper extremities, the patient presented with "calcinosis cutis" consisting of scattered nodules and plaques, some ulcerated and suppurating in both gluteal regions and on right elbow. (reumatologiaclinica.org)
  • Disorders of calcium-phosphate-parathormone balance, are very important issues in ESRD patients, that may lead to severe complications, as dystrophic calcinosis cutis, a rare disease, caused by calcium salt deposits in cutaneous or subcutaneous tissues and many organs. (giornaleitalianodinefrologia.it)
  • Histological exam revealed deposition of amorphic material with calcific component, consistent with cutaneous dystrophic calcinosis. (giornaleitalianodinefrologia.it)
  • Pets with calcinosis cutis typically have lesions (papules or plaques) with a gritty rough surface which may be quite itchy. (vcahospitals.com)
  • Others had significant improvement in calcinosis with no new lesions, decreased sites and density and decreased calcinosis related contractures. (scirp.org)
  • The outlook for calcinosis cutis depends on its underlying disease or cause, and the severity of your lesions. (puppy-party.info)
  • Generalized calcinosis rapidly progressed with high fever, multiple skin/subcutaneous inflammatory lesions, and increased level of CRP. (biomedcentral.com)
  • Because calcinosis cutis are not always well defined, a recurrence of the lesions may occur. (biomedcentral.com)
  • Abnormal deposition of calcium in the skin or subcutaneous tissue is termed calcinosis cutis. (biomedcentral.com)
  • Tumoral calcinosis is a rare condition in which there is calcium deposition in the soft tissue in periarticular location, around joints, outside the joint capsule. (wikipedia.org)
  • The name indicates calcinosis (calcium deposition) which resembles tumor (like a new growth). (wikipedia.org)
  • Iatrogenic calcinosis cutis is the deposition of calcium salts in the skin as a side effect of medical intervention for other disease processes. (uptodate.com)
  • The deposition of calcium in the skin, subcutaneous tissue, muscles and visceral organs is known as calcinosis. (dermnetnz.org)
  • Subdermal nodules and papules of calcium deposition on the posterior upper thigh of a patient with calcinosis cutis. (clinicaladvisor.com)
  • 12 A calcinosis that is characterized by massive periarticular, and seldom visceral, deposition of calcified tumors. (malacards.org)
  • Iatrogenic calcinosis cutis arises secondary to a treatment or procedure, for example parenteral administration of calcium or phosphate, and calcium deposition in newborns from repeated heel sticks. (puppy-party.info)
  • Calcinosis cutis is an uncommon disorder characterized deposition of crystals of calsium phosphate (hydroxyapatite) in the skin in various areas of the body. (biomedcentral.com)
  • Calcinosis cutis is an uncommon disorder which results in progressive deposition of insoluble calsium salts (crystals of calcium phosphate, hydroxyapatite) in the skin. (biomedcentral.com)
  • People with DM and JDM can develop calcium deposits in places they should not, known as calcinosis. (clinicaltrials.gov)
  • Medical therapy has very limited role in the treatment of calcinosis cutis but drugs like corticosteroids, probenecid, colchicine, sodium etidronate, diphosphonates, diltiazem, and magnesium and aluminium antacids can be used in order to relieve the symptoms9,10. (thefreedictionary.com)
  • Conclusion: Our study showed the favorable effect of rituximab in treatment of calcinosis in 4 patients with JDM-associated severe calcinosis when it was used with other conventional DMARDs. (scirp.org)
  • People ages 7 and older who have moderate or severe calcinosis. (clinicaltrials.gov)
  • Eligible patients will be age 7 or older, and will have extensive calcinosis (defined as calcinosis involving the torso or 2 extremities) and moderate to severe calcinosis (indicated by a calcinosis activity visual analogue scale score of greater than or equal to 3.5 cm out of 10 cm). (centerwatch.com)
  • Although iatrogenic calcinosis cutis is generally a benign entity, the early recognition of the presentation of extravasation of calcium gluconate is important to avoid severe complications and possible medical malpractice disputes. (biomedsearch.com)
  • We report the favorable outcome of rituximab on severe calcinosis in 4 JDM patients and present their clinical data. (scirp.org)
  • Patients and Methods: A retrospective chart review of 4 children with JDM and severe calcinosis who received rituximab for relapsing or polycyclic JDM course. (scirp.org)
  • Calcinosis was severe causing ulceration, recurrent skin infections and joint limitation. (scirp.org)
  • Frequent high fever and local severe pain with calcinosis were suppressed. (biomedcentral.com)
  • We report a case of severe calcinosis in a 14-year-old girl who was treated with thalidomide, a treatment encouraged by the partial effectiveness of etanercept, a soluble TNF receptor fusion protein. (biomedcentral.com)
  • Severe pulmonary calcinosis has not previously been reported in children with PHPT. (cu.edu.tr)
  • Diagnosis and follow up of calcinosis was clinically and by X-ray. (scirp.org)
  • A final diagnosis of calcinosis cutis was made based on histopathological and clinical findings. (oalib.com)
  • Based on clinical features and laboratory reports, a diagnosis of idiopathic calcinosis cutis of the scrotum was made. (biomedcentral.com)
  • Gastric mucosal calcinosis is a very rare pathologic diagnosis and we aimed to present this case with reference to the literature data. (heighpubs.org)
  • Calcinosis had been recognized 18 months after the diagnosis was made (Fig. 1 ). (biomedcentral.com)
  • Idiopathic calcinosis cutis of the scrotum is a benign condition, which remains mostly asymptomatic. (biomedcentral.com)
  • In addition to the classical clinical and biochemical features of hyperphosphatemic tumoral calcinosis, the patient exhibited markedly elevated intact and C-terminal FGF23 levels, suggestive of FGF23 resistance. (jci.org)
  • The authors present the clinical case of a dog with seropositive leishmaniosis and secondary immune-mediated haemolytic anaemia who was affected by intense dermatopathia on the dorsal area, diagnosed by a biopsy as calcinosis cutis. (bva.co.uk)
  • Pathology department's opinion was that the mucosal calcinosis observed in the corpus mucosa could be associated with calcium dysregulation and could also be secondary to medication, and recommended analyzing correlation with clinical findings. (heighpubs.org)
  • CREST ( calcinosis , Raynaud phenomenon , esophageal dysmotility , sclerodactyly, and telangiectasia) syndrome is a member of the heterogeneous group of sclerodermas , and its name is an acronym for the cardinal clinical features of the syndrome. (medscape.com)
  • McGuinness FE: Hyperphosphataemic tumoral calcinosis in Bedouin Arabs--clinical and radiological features. (statdx.com)
  • Noyez JF et al: Tumoral calcinosis, a clinical report of eleven cases. (statdx.com)
  • Clinical experience suggests the utility of sodium thiosulfate to treat delayed calcium extravasation in patients with severely debilitating, unresolving, or limb-threatening calcinosis cutis [Reynolds 2014] . (drugs.com)
  • Clinical presentation and radiographs of patient with tumoral calcinosis. (jci.org)
  • Calcinosis usually occurs in and just under skin tissue around the joints, most often the hips, shoulders, and elbows. (medlineplus.gov)
  • Rarely, calcinosis occurs in blood vessels or in the brain and can cause serious health problems. (medlineplus.gov)
  • Calcinosis cutis occurs in susceptible pets in areas where local skin damage has occurred. (vcahospitals.com)
  • Dystrophic calcinosis cutis typically occurs as a result of physical injury to tissues or reactions to injections and other foreign materials that tissues may be exposed to. (vcahospitals.com)
  • Calcinosis cutis occurs when calcium salts are deposited into the skin and subcutaneous tissue. (statpearls.com)
  • The onset of calcinosis usually occurs one to three years after that of the illness. (biomedcentral.com)
  • Radiography of her hands revealed the resorption of the distal phalangeal tufts (acro-osteolysis) and soft tissue calcifications ( calcinosis cutis) (Figure 2). (thefreedictionary.com)
  • Tumoral calcinosis presents as large, painless periarticular calcifications, most commonly in the hips and shoulders. (clinicaladvisor.com)
  • B ) Radiograph of the lesion revealed a soft tissue mass with amorphous calcifications around the right greater trochanter consistent with tumoral calcinosis. (jci.org)
  • Reciprocally tumoral calcinosis (TC) patients are often hyperphosphatemic with inappropriately normal or elevated serum 1,25(OH) 2 D 3 levels and have eciopic and vascular calcifications, a phenotype similar to that of Fgf23 null mice. (elsevier.com)
  • The pathogenesis of idiopathic calcinosis cutis of the scrotum is debatable. (biomedcentral.com)
  • Here we report a case of idiopathic calcinosis cutis of the scrotum with a brief review of the literature and a discussion on pathogenesis. (biomedcentral.com)
  • Our understanding of the pathogenesis of calcinosis is still very limited. (biomedcentral.com)
  • Lesion distribution in calcinosis cutis is closely connected to its etiology. (clinicaladvisor.com)
  • Calcinosis is the formation of calcium deposits in any soft tissue. (wikipedia.org)
  • Calcinosis typically develops in early childhood to early adulthood, although in some people the deposits first appear in infancy or in late adulthood. (medlineplus.gov)
  • Calcinosis results when the excess phosphate combines with calcium to form deposits that build up in soft tissues. (medlineplus.gov)
  • These include growth retardation and rickets (a disease affecting bone development) in children, and a series of metabolic disorders such as low potassium levels (hypokalemia), high calcium levels (hypercalcemia), elevated calcium in the urine (hypercalciuria) resulting in kidney stones, the formation of calcium deposits in the kidneys ( calcinosis ) as well as possible kidney failure. (thefreedictionary.com)
  • Bilateral striopallidodentate calcinosis (BSPDC, also erroneously called Fahr disease) is characterized by the accumulation of calcium deposits in different brain regions, particularly the basal ganglia and dentate nucleus, and is often associated with neurodegeneration. (orpha.net)
  • On physical examination, calcinosis cutis' dermal calcium deposits present as numerous, firm dermal or subcutaneous papules, nodules, or plaques with either a white or yellow coloring (Figure 1, Figure 2). (clinicaladvisor.com)
  • Calcinosis or calcinosis cutis is the accumulation of calcium deposits in or under the skin. (sclerodermanews.com)
  • If calcinosis deposits do not cause discomfort or impede function, they may not require treatment and can be left alone if the patient so desires. (sclerodermanews.com)
  • Calcinosis deposits occasionally resolve themselves spontaneously . (sclerodermanews.com)
  • If calcinosis deposits become very painful, cause recurrent secondary infections or impair function, a doctor may recommend surgical removal . (sclerodermanews.com)
  • On histology of calcinosis cutisgranules and deposits of calcium are seen in the dermisoften with a surrounding foreign-body giant cell reaction. (puppy-party.info)
  • Calcinosis is a condition that manifests as calcium deposits in the skin and other tissues of the body. (medindia.net)
  • Over the 18 months of observation up to the present, she has had no inflammatory calcinosis, or needed any hospitalization, although established calcium deposits still remain. (biomedcentral.com)
  • We have recently seen a patient with tumoral calcinosis, a syndrome comprising hyperphosphatemia, normocalcemia, normal glomerular filtration rate (GFR), and extensive periarticular calcific masses. (annals.org)
  • Thus, this report describes the first case, to our knowledge, of autoimmune hyperphosphatemic tumoral calcinosis with pathogenic autoantibodies targeting FGF23. (jci.org)
  • 2 Subcutaneous calcinosis, as part of the CREST variant or diffuse variant, is often seen on the extensor surfaces and in areas that tend to have a lot of friction and is seen in approximately 58% of scleroderma patients. (appliedradiology.com)
  • 7 The combination of calcinosis and acro-osteolysis, as seen in Figure 2, is considered to be pathognomic for scleroderma. (appliedradiology.com)
  • Dystrophic calcinosis in a patient with overlap syndrome (scleroderma and rheumatoid arthritis) treated by leflunomide: A case report. (annals.org)
  • Uncommon localization of calcinosis cutis after liver transplantation. (medscape.com)
  • Idiopathic calcinosis cutis of the scrotum is an uncommon entity. (biomedcentral.com)
  • Subepidermal calcified nodules or Winder nodular calcinosis presents in children and can present at birth. (statpearls.com)
  • Liquefaction of calcinosis nodules with improvement of mobility occurred gradually. (macquariestemcells.com)
  • She is now 24 months post-transplant with no sign of disease activity and total disappearance of calcinosis nodules. (macquariestemcells.com)
  • An estimated 25 to 40 percent of those with CREST syndrome will develop calcinosis cutis after 10 years. (puppy-party.info)
  • We present a rare case of iatrogenic calcinosis cutis complicated by compartment syndrome secondary to extravasation of iv calcium gluconate in a neonate. (biomedsearch.com)
  • The genetic loci determining dystrophic cardiac calcinosis in an F2 intercross of resistant C57BL/6J and susceptible C3H/HeJ inbred strains were identified. (eurekamag.com)
  • McGregor DH et al: Nonfamilial tumoral calcinosis associated with chronic renal failure and secondary hyperparathyroidism: report of two cases with clinicopathological, immunohistochemical, and electron microscopic findings. (statdx.com)
  • Mawdsley Calcinosis Questionnaire is an 18-question survey, each question ranges from 0-10. (clinicaltrials.gov)
  • ABSTRACT: Background: Calcinosis is an important sequela of JDM which may cause significant morbidity and mortality. (scirp.org)
  • Patients met 2013 ACR/ EULAR criteria, 1980 ACR criteria, or at least three of five features of CREST ( calcinosis , Raynaud's phenomenon, esophageal dysmotility, sclerodactyly, telangiectasia) syndrome. (thefreedictionary.com)
  • To assess baseline cortical area and cortical porosity measured by HR-pQCT in SSc patients with calcinosis. (clinicaltrials.gov)
  • Recently published reports as well as personal observations within our group have suggested that intravenous sodium thiosulfate treatment may benefit calcinosis patients. (centerwatch.com)
  • All patients had improvement in disease activity and frequency of admission especially due to complications of calcinosis. (scirp.org)
  • In 1910, Thibierge and Weissenbach described the first case report of what was later called CRST (calcinosis cutis, Raynaud phenomenon, sclerodactyly, and telangiectasia) syndrome in English by Winterbauer who, in 1964, described a series of 8 patients with the features that make up the abbreviation CRST. (medscape.com)
  • This activity reviews the evaluation and management of calcinosis cutis and highlights the role of the interprofessional team in improving care for affected patients. (statpearls.com)
  • Explain the importance of improving coordination amongst the interprofessional team to enhance care and outcomes for patients affected by calcinosis cutis. (statpearls.com)
  • Pharmacist pharmacist was reduced and equivalent however stopped in calcinosis commonly four patients after prednisone. (auto-uitlaat.be)
  • Excessive vitamin D intake may also cause calcinosis and so can taking calcium or phosphate. (sclerodermanews.com)
  • Review the laboratory studies that should be obtained in the evaluation of calcinosis cutis. (statpearls.com)
  • Calcinosis may also develop in the soft tissue of the feet, legs, and hands. (medlineplus.gov)
  • This was considered to be consistent with Tumoral Calcinosis in the setting of long-standing renal disease. (thefreedictionary.com)
  • Tumoral calcinosis with renal calculus. (bvsalud.org)
  • To test if sodium thiosulfate (STS) can treat people with DM with calcinosis. (clinicaltrials.gov)
  • We do not directly treat Diffuse Calcinosis. (macquariestemcells.com)
  • TITLE: "Disappearance of diffuse calcinosis following autologous stem cell transplantation in a child with autoimmune disease" (Elhasid R., et al. (macquariestemcells.com)
  • Calcinosis cutis is commonly described, but its prevalence and appear few documented in literature. (clinicaltrials.gov)
  • Subcutaneous calcinosis, a disease tending to serious bodily disability, presents a most difficult therapeutic problem. (annals.org)
  • BACKGROUND: Dystrophic calcinosis cutis is a common manifestation in connective tissue diseases, but there's still no consensus on treatment. (puppy-party.info)
  • Pharmacological treatment in calcinosis cutis associated with connective-tissue diseases. (puppy-party.info)
  • CREST (calcinosis, Raynaud phenomenon, oesophageal dysmotility, sclerodactyly, and telangiectasia) syndrome comprising calcinosis cutis, Raynaud phenomenon, esophageal dysmotility, sclerodactyly and telangiectasia and primary sclerosing cholangitis are both chronic fibrotic diseases but the association between them is extremely rare. (biomedcentral.com)