Calcineurin
A CALCIUM and CALMODULIN-dependent serine/threonine protein phosphatase that is composed of the calcineurin A catalytic subunit and the calcineurin B regulatory subunit. Calcineurin has been shown to dephosphorylate a number of phosphoproteins including HISTONES; MYOSIN LIGHT CHAIN; and the regulatory subunits of CAMP-DEPENDENT PROTEIN KINASES. It is involved in the regulation of signal transduction and is the target of an important class of immunophilin-immunosuppressive drug complexes.
Tacrolimus
NFATC Transcription Factors
A family of transcription factors characterized by the presence of highly conserved calcineurin- and DNA-binding domains. NFAT proteins are activated in the CYTOPLASM by the calcium-dependent phosphatase CALCINEURIN. They transduce calcium signals to the nucleus where they can interact with TRANSCRIPTION FACTOR AP-1 or NF-KAPPA B and initiate GENETIC TRANSCRIPTION of GENES involved in CELL DIFFERENTIATION and development. NFAT proteins stimulate T-CELL activation through the induction of IMMEDIATE-EARLY GENES such as INTERLEUKIN-2.
Cyclosporine
Calmodulin-Binding Proteins
Immunosuppressive Agents
Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.
Phosphoprotein Phosphatases
Tacrolimus Binding Proteins
Calcium
A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.
Signal Transduction
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Calmodulin
A heat-stable, low-molecular-weight activator protein found mainly in the brain and heart. The binding of calcium ions to this protein allows this protein to bind to cyclic nucleotide phosphodiesterases and to adenyl cyclase with subsequent activation. Thereby this protein modulates cyclic AMP and cyclic GMP levels.
Tacrolimus Binding Protein 1A
Cardiomegaly
Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the left, or both HEART VENTRICLES or HEART ATRIA. Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of CARDIOMYOPATHIES.
Amino Acid Isomerases
Sirolimus
A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation of cytokines thereby inhibiting cytokine production. It is bioactive only when bound to IMMUNOPHILINS. Sirolimus is a potent immunosuppressant and possesses both antifungal and antineoplastic properties.
Phosphoric Monoester Hydrolases
Calcium Signaling
Signal transduction mechanisms whereby calcium mobilization (from outside the cell or from intracellular storage pools) to the cytoplasm is triggered by external stimuli. Calcium signals are often seen to propagate as waves, oscillations, spikes, sparks, or puffs. The calcium acts as an intracellular messenger by activating calcium-responsive proteins.
Immunophilins
Members of a family of highly conserved proteins which are all cis-trans peptidyl-prolyl isomerases (PEPTIDYLPROLYL ISOMERASE). They bind the immunosuppressant drugs CYCLOSPORINE; TACROLIMUS and SIROLIMUS. They possess rotamase activity, which is inhibited by the immunosuppressant drugs that bind to them.
Transcription Factors
Phosphorylation
Cells, Cultured
Peptidylprolyl Isomerase
Muscle Proteins
Enzyme Inhibitors
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
DNA-Binding Proteins
Amino Acid Sequence
Mycophenolic Acid
An antibiotic substance derived from Penicillium stoloniferum, and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of the enzyme inosine monophosphate dehydrogenase. Mycophenolic acid is important because of its selective effects on the immune system. It prevents the proliferation of T-cells, lymphocytes, and the formation of antibodies from B-cells. It also may inhibit recruitment of leukocytes to inflammatory sites. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1301)
Nuclear Proteins
Graft Rejection
Encyclopedias as Topic
Protein Phosphatase 2
A phosphoprotein phosphatase subtype that is comprised of a catalytic subunit and two different regulatory subunits. At least two genes encode isoforms of the protein phosphatase catalytic subunit, while several isoforms of regulatory subunits exist due to the presence of multiple genes and the alternative splicing of their mRNAs. Protein phosphatase 2 acts on a broad variety of cellular proteins and may play a role as a regulator of intracellular signaling processes.
Okadaic Acid
Protein Phosphatase 1
A eukayrotic protein serine-threonine phosphatase subtype that dephosphorylates a wide variety of cellular proteins. The enzyme is comprised of a catalytic subunit and regulatory subunit. Several isoforms of the protein phosphatase catalytic subunit exist due to the presence of multiple genes and the alternative splicing of their mRNAs. A large number of proteins have been shown to act as regulatory subunits for this enzyme. Many of the regulatory subunits have additional cellular functions.
The role of immunophilins in mutant superoxide dismutase-1linked familial amyotrophic lateral sclerosis. (1/2213)
It has been reported that expression of familial amyotrophic lateral sclerosis (FALS)-associated mutant Cu/Zn superoxide dismutase-1 (SOD) induces apoptosis of neuronal cells in culture associated with an increase in reactive oxygen species. SOD recently has been shown to prevent calcineurin inactivation, initiating the present investigations examining the role of calcineurin in mutant SOD-induced cell death. Wild-type or mutant SOD was expressed in neuronal cells by infection with replication-deficient adenoviruses. PC12 cells overexpressing human wild-type SOD exhibited higher calcineurin activity than cells expressing FALS-related mutant SOD (SODV148G); however, cells expressing SODV148G had calcineurin activity equal to mock-infected cells, suggesting that cell death induced by mutant SOD was not related to a decrease in calcineurin activity. Calcineurin antagonists such as cyclosporin A and FK506, as well as nonimmunosuppressant analogs of cyclosporin A, significantly enhanced SODV148G- and SODA4V-induced cell death. Because both groups of drugs inhibit the rotamase activity of cyclophilins (CyP), but only the immunosuppressant analogs inhibit calcineurin activity, these data suggest that rotamase inhibition underlies the enhanced cell death after SODV148G expression. The importance of rotamase activity in mutant SOD-mediated apoptosis was supported by experiments showing that overexpressed wild-type cyclophilin A (CyPA), but not CyPA with a rotamase active site point mutation, protected cells from death after SODV148G expression. These data suggest that mutant SOD produces a greater need for rotamase and, also, highlights possible new therapeutic strategies in FALS. (+info)Differential effects of a calcineurin inhibitor on glutamate-induced phosphorylation of Ca2+/calmodulin-dependent protein kinases in cultured rat hippocampal neurons. (2/2213)
Calcium/calmodulin-dependent protein kinases (CaM kinases) are major multifunctional enzymes that play important roles in calcium-mediated signal transduction. To characterize their regulatory mechanisms in neurons, we compared glutamate-induced phosphorylation of CaM kinase IV and CaM kinase II in cultured rat hippocampal neurons. We observed that dephosphorylation of these kinases followed different time courses, suggesting different regulatory mechanisms for each kinase. Okadaic acid, an inhibitor of protein phosphatase (PP) 1 and PP2A, increased the phosphorylation of both kinases. In contrast, cyclosporin A, an inhibitor of calcineurin, showed different effects: the phosphorylation and activity of CaM kinase IV were significantly increased with this inhibitor, but those of CaM kinase II were not significantly increased. Cyclosporin A treatment of neurons increased phosphorylation of Thr196 of CaM kinase IV, the activated form with CaM kinase kinase, which was recognized with an anti-phospho-Thr196 antibody. Moreover, recombinant CaM kinase IV was dephosphorylated and inactivated with calcineurin as well as with PP1, PP2A, and PP2C in vitro. These results suggest that CaM kinase IV, but not CaM kinase II, is directly regulated with calcineurin. (+info)Reduction of calcineurin activity in brain by antisense oligonucleotides leads to persistent phosphorylation of tau protein at Thr181 and Thr231. (3/2213)
Phosphorylation of tau protein promotes stability of the axonal cytoskeleton; aberrant tau phosphorylation is implicated in the biogenesis of paired helical filaments (PHF) seen in Alzheimer's disease. Protein kinases and phosphatases that modulate tau phosphorylation have been identified using in vitro techniques; however, the role of these enzymes in vivo has not been determined. We used intraventricular infusions of antisense oligodeoxynucleotides (ODNs) directed against the major brain isoforms of the Ca2+/calmodulin-dependent phosphatase calcineurin to determine how reduced activity of this enzyme would affect tau dephosphorylation. Five-day infusions of antisense ODNs (5 and 10 nmol/day) in rats decreased immunoreactive levels and activity of calcineurin throughout the brain; sense ODNs, scrambled ODNs, and infusion vehicle alone had no effect. When neocortical slices were prepared from antisense ODN-treated rats and incubated for 1 to 2 h in vitro, tau protein remained phosphorylated as determined by using the phosphorylation-sensitive monoclonal antibodies AT-180 (Thr231) and AT-270 (Thr181). In contrast, AT-180 and AT-270 sites were completely dephosphorylated during incubation of neocortical slices from vehicle-infused controls and sense ODN-treated rats. Neocortical slices from antisense-treated rats were incubated with the phosphatase inhibitors okadaic acid (100 nM; 10 microM) and FK-520 (5 microM); these preparations showed enhanced tau phosphorylation, consistent with a significant loss of calcineurin activity. Thus, we conclude that phosphorylation of at least two sites on tau protein, namely, Thr181 and Thr231, is regulated by calcineurin. (+info)Failure of calcineurin inhibitors to prevent pressure-overload left ventricular hypertrophy in rats. (4/2213)
A rapidly emerging body of literature implicates a pivotal role for the Ca2+-calmodulin-dependent phosphatase calcineurin as a cellular target for a variety of Ca2+-dependent signaling pathways culminating in left ventricular hypertrophy (LVH). Most of the recent experimental support for this hypothesis is derived from in vitro studies or in vivo studies in transgenic mice expressing activated calcineurin or mutant sarcomeric proteins. The aim of the present study was to test whether calcineurin inhibitors, cyclosporin A (CsA) and FK 506, prevent pressure-overload LVH using 2 standard rat models: (1) the spontaneously hypertensive rat (SHR) and (2) aortic banding. The major new findings are 2-fold. First, in SHR, LVH (left ventricular weight to body weight ratio) was unaffected by a dose of CsA (5 mg. kg-1. d-1) that was sufficient to raise blood pressure and to inhibit calcineurin-mediated transcriptional activation in skeletal muscle. Second, in rats with aortic banding, LVH was unaffected by FK 506 (0.3 mg. kg-1. d-1) or even higher doses of CsA (10 and 20 mg. kg-1. d-1) that were sufficient to inhibit 90% of total calcineurin phosphatase activity in the hypertrophied myocardium. In the latter experiments, CsA blocked neither the elevated left ventricular end-diastolic pressures, a measure of diastolic function, nor the induction in atrial natriuretic peptide mRNA in the hypertrophic ventricles. Thus, in numerous experiments, systemic administration of potent calcineurin inhibitors did not prevent the development of LVH in 2 classic models of pressure-overload hypertrophy. These results demonstrate that pressure-overload hypertrophy can arise through calcineurin-independent pathways. (+info)Pressure overload induces severe hypertrophy in mice treated with cyclosporine, an inhibitor of calcineurin. (5/2213)
Cardiac hypertrophy is the fundamental adaptation of the adult heart to mechanical load. Recent work has shown that inhibition of calcineurin activity with cyclosporine suppresses the development of hypertrophy in calcineurin transgenic mice and in in vitro systems of neonatal rat cardiocytes stimulated with peptide growth factors. To test the hypothesis that the calcineurin signaling pathway is critical for load-induced hypertrophy in vivo, we examined the effects of cyclosporine treatment on left ventricular hypertrophy induced by experimental ascending aortic stenosis for 4 weeks in mice. Left ventricular systolic pressure was elevated to a similar level in aortic stenosis mice that were treated with cyclosporine versus no drug. Left ventricular mass and myocyte size were similar in treated and untreated aortic stenosis animals and significantly greater than control animals, showing that cyclosporine treatment does not suppress hypertrophic growth. Both treated and untreated animals showed increased left ventricular expression of the load-sensitive gene atrial natriuretic factor. Calcineurin activity was measured in the left ventricle and the spleen from control mice and aortic stenosis mice treated with cyclosporine versus no drug. Levels of calcineurin activity were similar in the spleens of control and untreated aortic stenosis mice. However, calcineurin activity was severely depressed in left ventricular tissue of untreated aortic stenosis mice compared with control mice and was further reduced by cyclosporine treatment. Thus, pathological hypertrophy and cardiac-restricted gene expression induced by pressure overload in vivo are not suppressed by treatment with cyclosporine and do not appear to depend on the elevation of left ventricular calcineurin activity. (+info)Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD. (6/2213)
The Ca2+-activated protein phosphatase calcineurin induces apoptosis, but the mechanism is unknown. Calcineurin was found to dephosphorylate BAD, a pro-apoptotic member of the Bcl-2 family, thus enhancing BAD heterodimerization with Bcl-xL and promoting apoptosis. The Ca2+-induced dephosphorylation of BAD correlated with its dissociation from 14-3-3 in the cytosol and translocation to mitochondria where Bcl-xL resides. In hippocampal neurons, L-glutamate, an inducer of Ca2+ influx and calcineurin activation, triggered mitochondrial targeting of BAD and apoptosis, which were both suppressible by coexpression of a dominant-inhibitory mutant of calcineurin or pharmacological inhibitors of this phosphatase. Thus, a Ca2+-inducible mechanism for apoptosis induction operates by regulating BAD phosphorylation and localization in cells. (+info)Yeast calcineurin regulates nuclear localization of the Crz1p transcription factor through dephosphorylation. (7/2213)
Calcineurin, a Ca2+/calmodulin dependent protein phosphatase, regulates Ca2+-dependent processes in a wide variety of cells. In the yeast, Saccharomyces cerevisiae, calcineurin effects Ca2+-dependent changes in gene expression through regulation of the Crz1p transcription factor. We show here that calcineurin dephosphorylates Crz1p and that this results in translocation of Crz1p to the nucleus. We identify a region of Crz1p that is required for calcineurin-dependent regulation of its phosphorylation, localization, and activity, and show that this region has significant sequence simlarity to a portion of NF-AT, a family of mammalian transcription factors whose localization is also regulated by calcineurin. Thus, the mechanism of Ca2+/calcineurin-dependent signaling shows remarkable conservation between yeast and mammalian cells. (+info)A selective role of calcineurin aalpha in synaptic depotentiation in hippocampus. (8/2213)
Pharmacological studies have suggested that long-term potentiation (LTP) and long-term depression (LTD) and depotentiation, three forms of synaptic plasticity in the hippocampus, require the activity of the phosphatase calcineurin. At least two different isoforms of calcineurin are found in the central nervous system. To investigate whether all of these forms of synaptic plasticity require the same isoforms of calcineurin, we have examined LTD, depotentiation, and LTP in mice lacking the predominant calcineurin isoform in the central nervous system, Aalpha-/- mice. Depotentiation was abolished completely whereas neither LTD nor LTP were affected. These studies provide genetic evidence that the Aalpha isoform of calcineurin is important for the reversal of LTP in the hippocampus and indicate that depotentiation and LTD operate through somewhat different molecular mechanisms. (+info)
The role of modulatory calcineurin-interacting proteins in calcineurin signaling. - Semantic Scholar
A novel calcineurin-interacting protein, CNP-3, modulates calcineurin deficient phenotypes in Caenorhabditis elegans<...
Abstract 1480: A Cullin 4a E3 Ligase Complex Mediates Rapid Degradation of the Calcineurin Regulatory Protein MCIP1.4 In...
Calcineurin inhibits VCX1-dependent H+/Ca2+ exchange and induces Ca2+ ATPases in Saccharomyces cerevisiae. | Molecular and...
Calcineurin inhibits VCX1-dependent H+/Ca2+ exchange and induces Ca2+ ATPases in Saccharomyces cerevisiae. | Molecular and...
Calcineurin-mediated dephosphorylation of Drp1 contribu | Open-i
Calcineurin - Wikipedia
RCAN1 Antibody | scrazzl.com - Simply Connecting Science
Calcineurin is required for virulence of Cryptococcus neoformans | The EMBO Journal
Galactokinase is a Novel Modifier of Calcineurin-Induced Cardiomyopathy in Drosophila
Adelaide Research & Scholarship: Sotrastaurin in calcineurin inhibitor-free regimen using everolimus in de novo kidney...
Transcriptional regulation of chitin synthases by calcineurin controls paradoxical growth of Aspergillus fumigatus in response...
Identification of Calcineurin as a Key Signal in the Extinction of Fear Memory | Journal of Neuroscience
Glucocorticosteroid dependent decrease in the activity of calcineurin in the peripheral blood mononuclear cells of patients...
Novel inhibitors of the calcineurin/NFATc hub - alternatives to CsA and FK506? | Cell Communication and Signaling | Full Text
Inp53 is a calcineurin substrate. (A) Domain structure | Open-i
Study to Evaluate the Value of the Follow-up of CALCIneurin Activity to MOdulate Calcineurin Inhibitors-induced...
JCI -
Calcineurin inhibitors suppress acute graft-vs-host disease via NFAT-independent inhibition of T cell receptor signaling
CERTICOEUR: A Secondary Prevention Study of Skin Cancers in Heart Transplant Patients. Everolimus Versus Calcineurin Inhibitors...
CERTICOEUR: A Secondary Prevention Study of Skin Cancers in Heart Transplant Patients. Everolimus Versus Calcineurin Inhibitors...
A Role for Calcineurin Dysfunction in Schizophrenia? | Science Signaling
Genome-Wide Microarray Analyses Identify the Protein C Receptor as a Novel Calcineurin/Nuclear Factor of Activated T Cells...
Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins. - The Kennedy Institute of...
Plus it
In situ localization of rat testis-specific calcineurin B subunit isoform β1 in the developing rat testis<...
Calcineurin/NFAT Coupling Participates in Pathological, but not Physiological, Cardiac Hypertrophy | Circulation Research
Abstract 14707: Gene Therapy With Calsarcin-1-AAV9 Rescues Contractile Dysfunction In Angiotensin-II Treated Mice | Circulation
CNA1 (YLR433C) Result Summary | BioGRID
JCI -
ACTN3 genotype influences muscle performance through the regulation of calcineurin signaling
Biochemistry and Pharmacology of Calmodulin-Regulated Phosphatase Calcineurin<...
A phase II/III randomized, multicenter trial of prednisone/sirolimus versus prednisone/ sirolimus/calcineurin inhibitor for the...
Screening and Treating Transplant Coronary Artery Disease - Infectious Disease Advisor
北京大学医学部机构知识库([email protected]): Regulation of intracellular Ca2(+) and calcineurin by NO/PKG in proliferation of vascular smooth...
Cyclosporin C | Calcineurin inhibitor | Hello Bio
A Randomized Prospective Trial of Conversion to Everolimus Therapy From Calcineurin Inhibitor Based Maintenance...
Viladevall L~Arino J, 2004 / Papers / YeastPhenome.org
Genomic expression programs and the integration of the CD28 costimulatory signal in T cell activation. | Lewis-Sigler Institute
Difference between revisions of Myocyte - Rodinia
Difference between revisions of Myocyte - Rodinia
Gentaur Molecular :Alpha Dia \ Human Calcineurin B subunit protein WB +Ve control \ CALNB21-C
Calcineurin B抗体|Abcam中国|Anti-Calcineurin B抗体
The temporal profile of calcineurin inhibition by cyclosporine in vivo
JCI -
Age-dependent human β cell proliferation induced by glucagon-like peptide 1 and calcineurin signaling
JCI -
Age-dependent human β cell proliferation induced by glucagon-like peptide 1 and calcineurin signaling
JCI -
Age-dependent human β cell proliferation induced by glucagon-like peptide 1 and calcineurin signaling
Randomised controlled trial comparing ofatumumab to rituximab in children with steroid-dependent and calcineurin inhibitor...
Effect of Cyclosporin a on the Tumor Microenvironment by Yao Zhou
Inhibitory effect of antihypertensive drugs on calcineurin in cardiomyocytes<...
Calcium channel regulator Mid1 links TORC2-mediated changes in mitochondrial respiration to autophagy<...
Eczema News - Review of Clinical Trials for Eczema Therapeutics in Children - Eczema Blues
Conversion of Long-Term Kidney Transplant Recipients From Calcineurin Inhibitor Therapy to Everolimus : A Randomized,...
Reconsideration of Interactions Between Direct Oral Anticoagulants and Calcineurin Inhibitors
| Journal of...
Share it: Synthese und biochemische Parameter zell-impermeabler Cyclosporine
DIGITAL.CSIC: Identification of possible targets of the Aspergillus fumigatus CRZ1 homologue, CrzA
Structure of Aspergillus fumigatus calcineurin-FK506-FKBP12 complex reveals critical FKBP12-binding residues distinct from...
Conditional calcineurin knockout mice exhibit multiple abnormal behaviors related to schizophrenia | Proceedings of the...
Atopic Dermatitis in Emergency Medicine Medication: Topical steroids, Topical calcineurin Inhibitors, Topical Phosphodiesterase...
Ppp3r1 (untagged) - Mouse protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I) (cDNA clone MGC...
Negative Cardiovascular Consequences of Small Molecule Immunosuppressants<...
New and emerging trends in the treatment of atopic dermatitis | PPA
JCI -
Calcineurin/Nfat signaling is required for perinatal lung maturation and function
Research - steinbach lab
TESC - Calcineurin B homologous protein 3 - Homo sapiens (Human) - TESC gene & protein
Hope for Significant New Diabetes Treatment in Stanford Discovery | EmaxHealth
Mutagenetix > Incidental...
Calcineurin/NFAT Coupling Participates in Pathological, but not Physiological, Cardiac Hypertrophy | Circulation Research
Tmem110 - Wikipedia
DailyMed - Search Results for Calcineurin Inhibitors
Topical Treatments with Pimecrolimus, Tacrolimus and Medium- to High-Potency Corticosteroids, and Risk of Lymphoma - Abstract -...
Palmitoylethanolamide (palmitamide MEA) cream for protection & restauration of skin | palmitoylethanolamide4pain
Transient Inhibition of Interleukin 4 Signaling by T Cell Receptor Ligation | JEM
FKBP5 - PCR Primer Pair - SYBR | PrimePCR | Bio-Rad
Regulation of GATA-3 Expression during CD4 Lineage Differentiation | The Journal of Immunology
Roman V. Petrov | Temple Health
Proliferation signal inhibitors and post-transplant malignancies in heart transplantation: Practical clinical management...
NFAT Inhibitor, Cell-Permeable - Calbiochem | 480401
INT226404 - wiki-pain
INT226504 - wiki-pain
Plus it
Electrical stimulation modulates Wnt signaling and regulates genes for the motor endplate and calcium binding in muscle of rats...
Search
DIGITAL.CSIC: Calcineurin is an antagonist to PKA protein phosphorylation required for postmating filamentation and virulence,...
久米 一規(大学院先端物質科学研究科)
RCSB PDB - 2R28: The complex Structure of Calmodulin Bound to a Calcineurin Peptide
Sampling Serum in Patients With Vitiligo to Measure Disease Activity i by and John E. Harris
Immunology
DEVELOPMENTAL EXPRESSION OF FK506 BINDING PROTEINS AND CALCINEURIN IN RAT BRAIN | Biochemical Society Transactions
OriGene - Ppp3r2 (NM 021701) cDNA Clone
Pharmacology Section 2- Tacrolimus - Physeo
Psoriasis-Behandlung mit Fett
Product Overview anti-Calcineurin A Antibodies
NFATs and Vascular Injury - Gadiparthi Rao
Produk CNI PHYTO LITE, Herbal lami untuk Meningkatkan Kecerdasan Anak | CNI Center
CNA Guides | CNA Training Help - Part 3
Immunosuppressive drug
Calcineurin inhibitors and azathioprine have been linked with post-transplant malignancies and skin cancers in organ transplant ... It is a macrolide lactone and acts by inhibiting calcineurin. The drug is used primarily in liver and kidney transplantations, ... It binds to the immunophilin FKBP1A, followed by the binding of the complex to calcineurin and the inhibition of its ... Like tacrolimus, ciclosporin (Novartis' Sandimmune) is a calcineurin inhibitor (CNI). It has been in use since 1983 and is one ...
Minnie Sarwal
"Calcineurin Inhibitor Nephrotoxicity." Clinical Journal of The American Society of Nephrology, vol. 4, no. 2, 2009, pp. 481-508 ...
Nephrotoxicity
Naesens M, Kuypers DR, Sarwal M (2009). "Calcineurin inhibitor nephrotoxicity". Clin. J. Am. Soc. Nephrol. 4 (2): 481-509. doi: ...
Tacrolimus
... which acts via calmodulin to activate calcineurin. Calcineurin then dephosphorylates the transcription factor nuclear factor of ... Tacrolimus inhibits calcineurin, which is involved in the production of interleukin-2, a molecule that promotes the development ... ISBN 978-0-07-144040-0. Liu J, Farmer JD, Lane WS, Friedman J, Weissman I, Schreiber SL (August 1991). "Calcineurin is a common ... Tacrolimus is a macrolide calcineurin inhibitor. In T-cells, activation of the T-cell receptor normally increases intracellular ...
Ciclosporin
... 's main effect is to lower the activity of T-cells; it does so by inhibiting calcineurin in the calcineurin- ... which acts via calmodulin to activate calcineurin. Calcineurin then dephosphorylates the transcription factor NF-AT (nuclear ... Youn TJ, Piao H, Kwon JS, Choi SY, Kim HS, Park DG, Kim DW, Kim YG, Cho MC (December 2002). "Effects of the calcineurin ... It does this by forming a complex with cyclophilin to block the phosphatase activity of calcineurin, which in turn decreases ...
Calcipressin
In molecular biology, the calcipressin family of proteins negatively regulate calcineurin by direct binding. They are essential ... Calcipressin 1 is a phosphoprotein that increases its capacity to inhibit calcineurin when phosphorylated at the conserved ... Calcipressin 1 is also known as modulatory calcineurin-interacting protein 1 (MCIP1), Adapt78 and Down syndrome critical region ... Parry RV, June CH (September 2003). "Calcium-independent calcineurin regulation". Nat. Immunol. 4 (9): 821-3. doi:10.1038/ ...
T-cell receptor
... inducing a conformational change of the protein such that it can then bind and activate calcineurin. Calcineurin, in turn, ... When dephosphorylated by Calcineurin translocation of NFAT into the nucleus is possible. Additionally, there is evidence that ...
CABIN1
Calcineurin-binding protein cabin-1 is a protein that in humans is encoded by the CABIN1 gene. Calcineurin plays an important ... "Entrez Gene: CABIN1 calcineurin binding protein 1". Lai MM, Luo HR, Burnett PE, Hong JJ, Snyder SH (Nov 2000). "The calcineurin ... The protein encoded by this gene binds specifically to the activated form of calcineurin and inhibits calcineurin-mediated ... Sun L, Youn HD, Loh C, Stolow M, He W, Liu JO (Jun 1998). "Cabin 1, a negative regulator for calcineurin signaling in T ...
Graft-versus-host disease
These complexes inhibit calcineurin, block dephosphorylation of the transcription factor NFAT of activated T-cells and its ... Liu J, Farmer JD, Lane WS, Friedman J, Weissman I, Schreiber SL (August 1991). "Calcineurin is a common target of cyclophilin- ... Cyclosporine and tacrolimus are calcineurin inhibitors. The substances are structurally different but have the same mechanism ...
Wnt signaling pathway
Calcineurin activates TAK1 and NLK kinase, which can interfere with TCF/β-Catenin signaling in the canonical Wnt pathway. ... Increased calcium also activates calcineurin and CaMKII. CaMKII induces activation of the transcription factor NFAT, which ...
Patrick Hogan (biologist)
He investigated the protein-protein interactions between calcineurin and NFAT. Subsequently, he identified ORAI1 as the pore ... Li, Huiming; Rao, Anjana; Hogan, Patrick G. (2011). "Interaction of calcineurin with substrates and targeting proteins". Trends ... Hogan, Patrick G.; Chen, Lin; Nardone, Julie; Rao, Anjana (2003-09-15). "Transcriptional regulation by calcium, calcineurin, ... which is dephosphorylated by the calcium-regulated phosphatase calcineurin, and solved its structure in collaboration with the ...
PPP3R2
Calcineurin subunit B type 2 is a protein that in humans is encoded by the PPP3R2 gene. Among its related pathways are MAPK ... 2007). "The calcineurin activity profiles of cyclosporin and tacrolimus are different in stable renal transplant patients". ... 2007). "Calcineurin potentiates the activation of procaspase-3 by accelerating its proteolytic maturation". J. Biol. Chem. 282 ... Jang H, Cho EJ, Youn HD (2007). "A new calcineurin inhibition domain in Cabin1". Biochem. Biophys. Res. Commun. 359 (1): 129-35 ...
TRPC
When intracellular calcium reaches a threshold, it will activate the calcineurin /NFAT pathway. DAG activates the calcineurin/ ... The mechanism of how TRPC channels promote cardiac hypertrophy is through activation of the calcineurin pathway and the ... canonical transient receptor potential channels promote cardiomyocyte hypertrophy through activation of calcineurin signaling ...
PPARGC1A
PGC-1α leads to calcineurin activation. Akt and calcineurin are both activators of NF-kappa-B (p65). Through their activation, ...
Anjana Rao
They also showed that NFAT was regulated by calcium and the calcium-dependent phosphatase calcineurin, which removes phosphate ... Hogan, P. G.; Chen, L.; Nardone, J.; Rao, A. (2003-09-15). "Transcriptional regulation by calcium, calcineurin, and NFAT". ...
FKBP5
... a novel T-cell-specific immunophilin capable of calcineurin inhibition". Molecular and Cellular Biology. 15 (8): 4395-402. doi: ... It is thought to mediate calcineurin inhibition. It also interacts functionally with mature corticoid receptor hetero-complexes ... and FK506-binding protein that can mediate calcineurin inhibition". Biochemical and Biophysical Research Communications. 232 (2 ...
NFATC4
Graef IA, Chen F, Chen L, Kuo A, Crabtree GR (Jun 2001). "Signals transduced by Ca(2+)/calcineurin and NFATc3/c4 pattern the ... Molkentin JD, Lu JR, Antos CL, Markham B, Richardson J, Robbins J, Grant SR, Olson EN (Apr 1998). "A calcineurin-dependent ... "Entrez Gene: NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4". Yang T, Davis RJ, Chow CW (Oct ... Crabtree GR (Mar 1999). "Generic signals and specific outcomes: signaling through Ca2+, calcineurin, and NF-AT". Cell. 96 (5): ...
PPP3CA
Graef IA, Chen F, Chen L, Kuo A, Crabtree GR (June 2001). "Signals transduced by Ca(2+)/calcineurin and NFATc3/c4 pattern the ... Esau C, Boes M, Youn HD, Tatterson L, Liu JO, Chen J (November 2001). "Deletion of calcineurin and myocyte enhancer factor 2 ( ... Mukerjee N, McGinnis KM, Gnegy ME, Wang KK (August 2001). "Caspase-mediated calcineurin activation contributes to IL-2 release ... Crabtree GR (March 1999). "Generic signals and specific outcomes: signaling through Ca2+, calcineurin, and NF-AT". Cell. 96 (5 ...
Bump and hole
The orthogonal CID pair was used to inhibit calcineurin-mediated dephosphorylation of nuclear factor of activated T cells in a ... Belshaw, Peter J.; Schreiber, Stuart L. (February 1997). "Cell-Specific Calcineurin Inhibition by a Modified Cyclosporin". ...
DSCR1
The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways of genetic ... DSCR1 in human is located at the centromeric border of the DSCR and encodes an inhibitor of calcineurin/ NFAT (nuclear factor ... Ermak G, Hench KJ, Chang KT, Sachdev S, Davies KJ (May 2009). "Regulator of calcineurin (RCAN1-1L) is deficient in Huntington ... DSCR1 Consist of putative functional motifs and calcineurin binding domain. DSCR1 contains two proline-rich SH3 binding domain ...
Bcl-2-associated death promoter
21, 4066-4073, "Calcineurin Links Ca++ Dysregulation with Brain Aging"( Chen L, Willis SN, Wei A, Smith BJ, Fletcher JI, Hinds ... BAD phosphorylation is thus anti-apoptotic, and BAD dephosphorylation (e.g., by Ca2+-stimulated Calcineurin) is pro-apoptotic. ... "Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD". Science. 284 (5412): 339-43. Bibcode:1999Sci...284..339W ...
ADCY9
Paterson JM, Smith SM, Harmar AJ, Antoni FA (1995). "Control of a novel adenylyl cyclase by calcineurin". Biochem. Biophys. Res ...
PDE1
This phosphorylation can be reversed by the phosphatase, calcineurin. The phosphorylation of the isozymes is accompanied by a ...
Pimecrolimus
It has been shown in vitro that pimecrolimus binds to FKBP1A and also inhibits calcineurin.[citation needed] Thus pimecrolimus ... Spergel JM, Leung DY (2006). "Safety of topical calcineurin inhibitors in atopic dermatitis: evaluation of the evidence". Curr ... Pimecrolimus is an immunomodulating agent[clarification needed] of the calcineurin inhibitor class used in the treatment of ... Tacrolimus and pimecrolimus are both calcineurin inhibitors and function as immunosuppressants. In January 2006, the United ...
GATA4
1998). "A calcineurin-dependent transcriptional pathway for cardiac hypertrophy". Cell. 93 (2): 215-28. doi:10.1016/S0092-8674( ...
MYOZ1
Frey N, Richardson JA, Olson EN (2001). "Calsarcins, a novel family of sarcomeric calcineurin-binding proteins". Proc. Natl. ...
TFEB
Nutrient depletion induces TFEB dephosphorylation and subsequent nuclear translocation via the phosphatase calcineurin. TFEB ... "Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB". Nature Cell Biology. 17 (3): 288-99. doi: ...
Balanitis circinata
Topical corticosteroid therapy is the most commonly used treatment, and topical calcineurin inhibitors have also been used ... Stern RS (2006). "Topical calcineurin inhibitors labeling: putting the "box" in perspective". Archives of Dermatology. 142 (9 ... and topical calcineurin inhibitors have also been used successfully. Newer tests on patients showed that a less harmful off- ...
MYOZ2
Mice lacking the MYOZ2 gene (MYOZ2-/-) are generally sensitized to calcineurin signaling in both muscle types. In slow-skeletal ... Calsarcin-1 binds to alpha-actinin, gamma-filamin, telethonin, ZASP/Cypher and calcineurin. The binding region of calsarcin-1 ... However, upon calcineurin activation or pressure overload-induced pathologic hypertrophy, MYOZ2-/- exhibited exaggerated ... Frey N, Richardson JA, Olson EN (December 2000). "Calsarcins, a novel family of sarcomeric calcineurin-binding proteins". ...
Prostaglandin F receptor
PKC/Ca2+/Calcineurin/Nuclear factor of activated T-cells; and the EGF cellular receptor. In certain cells, activation of FP ...
Irritant Contact Dermatitis Medication: Corticosteroids, Topical, Calcineurin Inhibitors, Emollients
Balanitis Circumscripta Plasmacellularis Medication: Topical Calcineurin Inhibitors
Calcineurin - Wikipedia
Calcineurin is a heterodimer of a 61-kD calmodulin-binding catalytic subunit, calcineurin A and a 19-kD Ca2+-binding regulatory ... Calcineurin is the target of a class of drugs called calcineurin inhibitors, which include ciclosporin, voclosporin, ... Calcineurin/NFAT signaling is required for perinatal lung maturation and function. Calcineurin inhibitors such as tacrolimus ... Wang MG, Yi H, Guerini D, Klee CB, McBride OW (1996). "Calcineurin A alpha (PPP3CA), calcineurin A beta (PPP3CB) and ...
MicroRNA-Mediated Calcineurin Signaling Activation Induces CCL2, CCL3, CCL5, IL8 and Chemotactic Activities in 4,4'-Methylene...
MicroRNA-Mediated Calcineurin Signaling Activation Induces CCL2, CCL3, CCL5, IL8 and Chemotactic Activities in 4,4-Methylene ... Lin, CC, Law, BF, and Hettick, JM (2021). MicroRNA-Mediated Calcineurin Signaling Activation Induces CCL2, CCL3, CCL5, IL8 and ... Previously, we demonstrated a microRNA (miR)-206-3p and miR-381-3p mediated PPP3CA/Calcineurin signaling induced inducible ... we investigated the roles of miR-mediated calcineurin signaling in regulation of these candidate mediators expressions in ...
Calcineurin Inhibitors | Drug, OTCs & Herbals | Medscape Reference
Calcineurin and Cardiac Disease | The Scientist Magazine®
J.D. Molkentin, J.R. Lu, C.L. Antos, B. Markham, J. Richardson, J. Robbins, S.R. Grant, E.N. Olson, A calcineurin-dependent ... Calcineurin and Cardiac Disease. For this article, Eugene Russo interviewed Eric N. Olson, chair of molecular biology at the ... J.D. Molkentin, J.R. Lu, C.L. Antos, B. Markham, J. Richardson, J. Robbins, S.R. Grant, E.N. Olson, "A calcineurin-dependent ... J.D. Molkentin, J.R. Lu, C.L. Antos, B. Markham, J. Richardson, J. Robbins, S.R. Grant, E.N. Olson, "A calcineurin-dependent ...
Good fungi gone bad: the corruption of calcineurin
Genetic studies in yeast and fungi established the molecular basis of calcineurin inhibiti … ... Calcineurin is a Ca(2+)/calmodulin-activated protein phosphatase that is conserved in eukaryotes, from yeast to humans, and is ... comparisons of calcineurin function in both fungi and humans may identify fungal-specific components of calcineurin-signaling ... Good fungi gone bad: the corruption of calcineurin Bioessays. 2002 Oct;24(10):894-903. doi: 10.1002/bies.10157. ...
calcineurin inhibitor Archives - Lupus Research
calcineurin complex | Semantic Scholar
calcineurin complex. Known as: calcineurin complex location, protein phosphatase type 2B complex, protein phosphatase type 2B ... Sperm-specific calcineurin is a novel fertility and contraceptive target [Also see Report by Miyata et al.] The population of ... Calcineurin, a heterodimer composed of the catalytic (CnaA) and regulatory (CnaB) subunits, plays key roles in growth, ... Localization and activity of the calcineurin catalytic and regulatory subunit complex at the septum is essential for hyphal ...
Calcineurin Activity Is Increased in Charcot-Marie-Tooth 1B Demyelinating Neuropathy | Journal of Neuroscience
Calcineurin assay. The enzymatic activity of calcineurin was measured using the calcineurin cellular activity assay kit from ... The role of calcineurin in S63del Schwann cells. Calcineurin activity has been shown to be both toxic and beneficial in several ... P-PERK binds calcineurin in S63del sciatic nerve. A, Calcineurin immunoprecipitation was performed on P28 sciatic nerve from WT ... Calcineurin can still be a substrate of PERK kinase, and perhaps calcineurin has a relevant feedback effect on PERK activity ...
Search of: MYCOPHENOLIC ACID AND transplant recipients AND renal transplant AND Calcineurin AND Tacrolimus AND Tacrolimus AND...
Calcineurin inhibitory peptide - BML-PR104 - Enzo Life Sciences
Capsaicin presynaptically inhibits glutamate release through the activation of TRPV1 and calcineurin in the hippocampus of rats...
... capsaicin increased the 4-aminopyridine-induced phosphorylation of protein phosphatase calcineurin and the calcineurin ... Together, these results suggest that capsaicin acts at TRPV1 present on hippocampal nerve terminals to increase calcineurin ... Capsaicin presynaptically inhibits glutamate release through the activation of TRPV1 and calcineurin in the hippocampus of rats ... Capsaicin presynaptically inhibits glutamate release through the activation of TRPV1 and calcineurin in the hippocampus of rats ...
Black box warning for topical calcineurin inhibitors and the death of common sense
The case of calcineurin inhibitors is not unique in the US. In the case of systemic isotretinoin, which does not increase the ... Black box warning for topical calcineurin inhibitors and the death of common sense. Alan B Fleischer Jr MD Dermatology Online ... In the recent past the FDA has elected to modify the labeling of the two topical calcineurin inhibitors, tacrolimus and ... Thus, the risk of cancer is strikingly less in the calcineurin treated subjects compared with those in the vehicle or ...
Calcineurin sets the bandwidth for discrimination of signals during thymocyte development - Document - Gale Academic OneFile...
Calcineurin B1 (Cnbl)-deficient CD[4.sup.+] CD[8.sup.+] double-positive thymocytes lack calcineurin activity, fail to ... Analysis of mice deficient in both Bim (which is required for negative selection) and calcineurin revealed that calcineurin- ... The calcineurin/NFAT (3,4] and the Raf-MEK-ERK (5-7) pathways have been shown to be required for positive selection of ... To test whether calcineurin activity was directly required for Raf activation, we stimulated thymocytes in the presence of the ...
A Low Tacrolimus Concentration/Dose Ratio Increases the Risk for the Development of Acute Calcineurin Inhibitor-Induced...
calcineurin inhibitor nephrotoxcity; tacrolimus; C/D ratio; tacrolimus metabolism; kidney transplantation. DDC Subject:. 610: ... Renal calcineurin-inhibitor toxicity is a common adverse effect of tacrolimus therapy. The present contribution hypothesized ... Renal calcineurin-inhibitor toxicity is a common adverse effect of tacrolimus therapy. The present contribution hypothesized ... A Low Tacrolimus Concentration/Dose Ratio Increases the Risk for the Development of Acute Calcineurin Inhibitor-Induced ...
RePub, Erasmus University Repository:
Measuring Intracellular Concentrations of Calcineurin Inhibitors: Expert Consensus from...
Background: Therapeutic drug monitoring (TDM) of the 2 calcineurin inhibitors (CNIs), tacrolimus (TAC) and cyclosporin A, has ... Measuring Intracellular Concentrations of Calcineurin Inhibitors: Expert Consensus from the International Association of ... Measuring Intracellular Concentrations of Calcineurin Inhibitors: Expert Consensus from the International Association of ...
Calcineurin target CrzA regulates conidial germination, hyphal growth, and pathogenesis of Aspergillus fumigatus. | Scholars...
Calcineurin target CrzA regulates conidial germination, hyphal growth, and pathogenesis of Aspergillus fumigatus. ... The calcineurin pathway is a critical signal transduction pathway in fungi that mediates growth, morphology, stress responses, ... Calcineurin target CrzA regulates conidial germination, hyphal growth, and pathogenesis of Aspergillus fumigatus. Journal ... Our results suggest that CrzA is an important downstream effector of calcineurin that controls morphology in A. fumigatus, but ...
Systematic review of published trials: long-term safety of topical corticosteroids and topical calcineurin inhibitors in...
Topical calcineurin inhibitors (TCIs), tacrolimus and pimecrolimus, available for 1-2 decades, are not associated with atrophy ... From: Systematic review of published trials: long-term safety of topical corticosteroids and topical calcineurin inhibitors in ... no scientific evidence of an increased risk for malignancy due to a topical treatment with calcineurin inhibitors. ... topical calcineurin inhibitor OR TCI OR pimecrolimus OR tacrolimus) AND (atopic dermatitis OR eczema), and filtering for meta- ...
Plasma membrane calcium ATPase isoform 4 inhibits vascular endothelial growth factor-mediated angiogenesis through interaction...
... as an endogenous inhibitor of the calcineurin/NFAT pathway, via interaction with calcineurin, in cardiomyocytes and breast ... Among the intracellular signaling pathways triggered by VEGF, activation of the calcineurin/nuclear factor of activated T cells ... However, the functional significance of the PMCA/calcineurin interaction in endothelial pathophysiology has not been addressed ... CONCLUSIONS: Given the importance of the calcineurin/NFAT pathway in the regulation of pathological angiogenesis, targeted ...
Visualization of phosphatase activity in living cells with a FRET-based calcineurin activity sensor<...
Newman RH, Zhang J. Visualization of phosphatase activity in living cells with a FRET-based calcineurin activity sensor. ... Visualization of phosphatase activity in living cells with a FRET-based calcineurin activity sensor. In: Molecular BioSystems. ... Using this reporter, calcineurin activity can be monitored as dephosphorylation-induced increases in fluorescence resonance ... Using this reporter, calcineurin activity can be monitored as dephosphorylation-induced increases in fluorescence resonance ...
Simulating Complex Calcium-Calcineurin Signaling Network - Physiome Model Repository
Balanitis Circumscripta Plasmacellularis Medication: Topical Calcineurin Inhibitors
A significant increase in both basal and maximal calcineurin activity in the rat pilocarpine model of status epilepticus -...
Oxidative inactivation of calcineurin by Cu,Zn superoxide dismutase G93A, a mutant typical of familial amyotrophic lateral...
N2 - Calcineurin is a serine/threonine phosphatase involved in a wide range of cellular responses to calcium mobilizing signals ... AB - Calcineurin is a serine/threonine phosphatase involved in a wide range of cellular responses to calcium mobilizing signals ... Calcineurin is a serine/threonine phosphatase involved in a wide range of cellular responses to calcium mobilizing signals. ... abstract = "Calcineurin is a serine/threonine phosphatase involved in a wide range of cellular responses to calcium mobilizing ...
Lupus Nephritis Medication: Corticosteroids, Immunosuppressives, Monoclonal Antibodies, Calcineurin Inhibitors
Calcineurin Inhibitors. Class Summary. Through the inhibition of calcineurin, these therapies reduce cytokine activation, block ... Mok CC, Jayne D. Pro: The use of calcineurin inhibitors in the treatment of lupus nephritis. Nephrol Dial Transplant. 2016 Sep ... Con: The use of calcineurin inhibitors in the treatment of lupus nephritis. Nephrol Dial Transplant. 2016 Sep 1. [QxMD MEDLINE ... Novel high potency calcineurin-inhibitor reduces T-cell activation and stabilizes podocytes, which protect against proteinuria ...
JCI Insight -
Histone deacetylase inhibitor panobinostat induces calcineurin degradation in multiple myeloma
Here, we demonstrate how calcineurin, when inhibited by immunosuppressive drugs like FK506, is involved in myeloma cell growth ... Our findings underscore the usefulness of calcineurin-targeted therapy in MM patients, including patients who are resistant to ... a catalytic subunit of calcineurin, was high in advanced patients. Panobinostat degraded PPP3CA, a degradation that should have ...
IMSEAR at SEARO: Calcineurin inhibitor toxicity in renal allografts: Morphologic clues from protocol biopsies.
Calcineurin inhibitor toxicity in renal allografts: Morphologic clues from protocol biopsies.. Authors: Sharma, Alok. Jain, ... Histological features of calcineurin inhibitor toxicity (CNIT) have been the subject of few studies using protocol biopsy ... Calcineurin inhibitor toxicity in renal allografts: Morphologic clues from protocol biopsies. Indian Journal of Pathology & ... Background: Calcineurin inhibitors (cyclosporine and tacrolimus) are important constituents of post renal transplant ...
Calcineurin Inhibitors | Profiles RNS
"Calcineurin Inhibitors" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ... This graph shows the total number of publications written about "Calcineurin Inhibitors" by people in this website by year, and ... Below are the most recent publications written about "Calcineurin Inhibitors" by people in Profiles. ... Drug interactions between direct-acting oral anticoagulants and calcineurin inhibitors during solid organ transplantation: ...
CyclosporineImmunosuppressantInhibition of calcineurinCorticosteroidsNFATPathwayCalciumPHOSPHATASE activity of CALCINEURINDeveloping calcineurin-inhibitorPimecrolimus and tacrolimusRole for calcineurinAbstractInducesFK506Inhibit calcineurinObserved that calcineurin activityTreatment with calcineurin inhibitorsSustained calcineurin activityCalmodulin dependentProtein phosphatase 2BRenal transplantTest whether calcineurinActivation of calcineurinWithdrawal of calcineurinDifferences in calcineurinTacrolimus and pimecrolimusRegulatory subunitToxicitySteroidsCyclosporinInhibits calcineurinActivityRegulationCNIsImmunosuppressivePPP3CAGraft versusImmunosuppressionNuclearVirulenceCytoplasmicDephosphorylationSignal TransductionTranscriptionPathwaysRegulatesImmune system
Cyclosporine9
- Furthermore, capsaicin increased the 4-aminopyridine-induced phosphorylation of protein phosphatase calcineurin and the calcineurin inhibitor cyclosporine A eliminated the inhibitory effect of capsaicin on evoked glutamate release. (rsc.org)
- Background: Calcineurin inhibitors (cyclosporine and tacrolimus) are important constituents of post renal transplant immunosuppression. (who.int)
- This project is of clinical relevance because cyclosporine A is a known inhibitor of calcineurin. (chop.edu)
- The addition of calcineurin inhibitors including cyclosporine A (CsA) and FK-506 (tacrolimus) to transplant protocols has markedly reduced acute allograft rejection and long term patient success. (globaltechbiz.com)
- The activation from the TCR complicated leads towards the discharge of intracellular calcium mineral and calcineurin-mediated dephosphorylation of transcription KU-60019 elements that regulate IL-2 and various other proinflammatory cytokines (Macian 2005 Cyclosporine A (CsA) and FK-506 (tacrolimus) are structurally unrelated substances that type drug-receptor complexes with immunophilins (cyclophilin-18 and FK506 binding proteins-12 respectively) and potently inhibit calcineurin phosphatase activity. (globaltechbiz.com)
- Prior research of calcineurin activity in vivo possess focused on problems including pharmacodynamics in response to cyclosporine and tacrolimus (Koefoed-Nielsen and Jorgensen 2002 Koefoed-Nielsen et al. (globaltechbiz.com)
- The calcineurin inhibitor cyclosporine (CsA) induces a fibrogenic response that may lead to scarring of the renal allograft. (rug.nl)
- CEQUA (cyclosporine ophthalmic solution) 0.09% contains a topical calcineurin inhibitor immunosuppressant. (drugs.com)
- The trial evaluated abatacept when added to a standard-of-care regimen (methotrexate plus a calcineurin inhibitor, either cyclosporine or tacrolimus) for prophylaxis of acute GVHD. (dana-farber.org)
Immunosuppressant6
- Other, the vendors in the ministry will take them without fear that works a host of a calcineurin inhibitor immunosuppressant indicated to talk to our customers online pharmacies or doctors. (publictell.com)
- Calcineurin Inhibitor Immunosuppressant, ClinCalc DrugStats Database, Version 2022.08. (clincalc.com)
- Topical calcineurin inhibitors (pimecrolimus and tacrolimus) are also anti-inflammatory and immunosuppressant and can be used as an alternative to topical steroids. (bsaci.org)
- Cequa Ophthalmic Solution is a calcineurin inhibitor immunosuppressant indicated to increase tear production in patients with keratoconjunctivitis sicca (dry eye). (drugs.com)
- Tacrolimus is an immunosuppressant that acts by inhibiting calcineurin, an enzyme that is involved in T-cell activation by binding to the immunophilin FKBP5. (psychiatrist.com)
- LUPKYNIS® is the first U.S. FDA-approved and EC-approved oral medicine for the treatment of adult patients with active lupus nephritis (LN). LUPKYNIS is a novel, structurally modified calcineurin inhibitor (CNI) with a dual mechanism of action, acting as an immunosuppressant through inhibition of T-cell activation and cytokine production and promoting podocyte stability in the kidney. (businesswire.com)
Inhibition of calcineurin5
- Acute in vitro inhibition of MEK1/2 with U0126 but not inhibition of calcineurin activity with CsA impaired ERK1/2 phosphorylation and Egr1 induction (Fig. 2a, b). (gale.com)
- PMCA4-dependent inhibition of calcineurin signaling translates into a reduction in endothelial cell motility and blood vessel formation that ultimately impairs in vivo angiogenesis by VEGF. (uni.lu)
- It has not been clear, however, whether these effects are specific for the distal convoluted tubule, and whether these represent off-target toxic drug effects, or result from inhibition of calcineurin. (elsevier.com)
- Although it can be done that these real estate agents may exert their results through unrelated systems, their commonality regarding immune system function (inhibition of calcineurin signalling) suggests a potential system [4]. (happydiwali2014wishesms.org)
- NSC-23766 HCl We further show that a immediate inhibition of calcineurin by cypermethrin (which functions individually of immunophilins) also promotes engine neuron success following axotomy. (happydiwali2014wishesms.org)
Corticosteroids6
- Topical calcineurin inhibitors can be used as an alternative to topical corticosteroids. (medscape.com)
- Acute flares of eczema may need to be controlled with moderate-to-potent topical corticosteroids for 3 to 5 days before stepping down to a calcineurin inhibitor, and clinical infection at the site should be treated before topical calcineurin inhibitors are used. (bsaci.org)
- Topical corticosteroids (TCS) and more recently topical calcineurin inhibitors (TCI) provide efficacious first and second-line respective topical anti-inflammatory (TAI) therapies for both adults and children with acute flares of AD (10, 11). (medicaljournals.se)
- First-line therapy for AD includes moisturizers, topical corticosteroids (TCS), and topical calcineurin inhibitors (TCIs). (uspharmacist.com)
- Topical therapies (topical corticosteroids or topical calcineurin inhibitors eg. (singhealth.com.sg)
- Low- or medium-dose topical corticosteroids or topical calcineurin inhibitors were continued if patients were using the treatments at randomization. (consultantlive.com)
NFAT17
- Calcineurin along with NFAT, may improve the function of diabetics' pancreatic beta cells. (wikipedia.org)
- Calcineurin/NFAT signaling is required for perinatal lung maturation and function. (wikipedia.org)
- Here we show that mice deficient in both calcineurin and nuclear factor of activated T cells (NFAT)c2/c3 lack a population of preselection thymocytes with enhanced ability to activate the mitogen-activated protein kinase (Raf-MEK-ERK) pathway, and fail to undergo positive selection. (gale.com)
- These results indicate that early calcineurin/ NFAT signalling produces a developmental period of ERK hypersensitivity, allowing very weak signals to induce positive selection. (gale.com)
- The calcineurin/NFAT (3,4] and the Raf-MEK-ERK (5-7) pathways have been shown to be required for positive selection of thymocytes but not for their negative selection. (gale.com)
- Among the intracellular signaling pathways triggered by VEGF, activation of the calcineurin/nuclear factor of activated T cells (NFAT) signaling axis has emerged as a critical mediator of angiogenic processes. (uni.lu)
- We and others previously reported a novel role for the plasma membrane calcium ATPase (PMCA) as an endogenous inhibitor of the calcineurin/NFAT pathway, via interaction with calcineurin, in cardiomyocytes and breast cancer cells. (uni.lu)
- APPROACH AND RESULTS: Using in vitro and in vivo assays, we here demonstrate that the interaction between PMCA4 and calcineurin in VEGF-stimulated endothelial cells leads to downregulation of the calcineurin/NFAT pathway and to a significant reduction in the subsequent expression of the NFAT-dependent, VEGF-activated, proangiogenic genes RCAN1.4 and Cox-2. (uni.lu)
- CONCLUSIONS: Given the importance of the calcineurin/NFAT pathway in the regulation of pathological angiogenesis, targeted modulation of PMCA4 functionality might open novel therapeutic avenues to promote or attenuate new vessel formation in diseases that occur with angiogenesis. (uni.lu)
- In time, a slow and steady rise in basal cell calcium levels leads to activation of calcineurin, which leads to nuclear importation of the transcription factor NFAT (Nuclear Factor of T-cells). (chop.edu)
- AAV-Gfa2 vectors carry a payload (i.e. the peptide VIVIT) that interferes with the calcineurin (CN)-dependent transcription factor NFAT (Nuclear Factor of Activated T cells), shown by our lab and others to orchestrate biochemical cascades leading to astrocyte activation. (uky.edu)
- Pretreatment of cells with cyclosporin A (CSA), a pharmacological inhibitor of the phosphatase calcineurin, blocked both asbestos - and TPA plus asbestos -induced NFAT activation. (cdc.gov)
- Dr. Lee and his colleagues focused on the potential role of a transcription factor called nuclear factor of activated T cells (NFAT), as well as calcineurin, the signaling protein that activates NFAT. (oref.org)
- They tested the hypothesis that wear debris triggers the calcineurin/NFAT axis leading to the production of several osteolysis-related cytokines. (oref.org)
- Researchers on the current study were encouraged by how effectively the TRPC6 pathway (TRPC6-calcineurin-NFAT) appeared to influence the transformation of fibroblasts into myofibroblasts, the secretion of extracellular matrix, wound healing and fibrosis. (cincinnatichildrens.org)
- Anabolic steroids activate calcineurin-NFAT signaling and thereby increase myotube size and reduce denervation atrophy. (alaskaice.org)
- For instance investigators here have provided evidence for dysregulated signaling through the NFAT/calcineurin pathway in Down syndrome (DS), which arises in patients with trisomy for chromosome 21. (ca.gov)
Pathway6
- It so happens that the pathway they discovered is governed by the calcium-dependent phosphatase calcineurin, the very same phosphatase that has routinely been the target. (the-scientist.com)
- We therefore investigated the hypothesis that PERK may interfere with signals outside of the UPR and specifically with calcineurin/NFATc4 pro-myelinating pathway. (jneurosci.org)
- The calcineurin pathway is a critical signal transduction pathway in fungi that mediates growth, morphology, stress responses, and pathogenicity. (duke.edu)
- The importance of the calcineurin pathway in fungal physiology creates an opportunity for the development of new antifungal therapies that target this critical signaling pathway. (duke.edu)
- In this study, we examined the molecular interplay among these molecules, finding that Rho family guanosine triphosphatase signaling occurs either downstream of calcineurin or as a required, parallel pathway. (tamu.edu)
- Increased activity of the calcineurin-nuclear factor of activated T cells pathway in squirrel monkey B-Lymphoblasts identified by PowerBlot. (waldenu.edu)
Calcium14
- Calcineurin (CaN) is a calcium and calmodulin dependent serine/threonine protein phosphatase (also known as protein phosphatase 3, and calcium-dependent serine-threonine phosphatase). (wikipedia.org)
- When an antigen-presenting cell interacts with a T cell receptor on T cells, there is an increase in the cytoplasmic level of calcium, which activates calcineurin by binding a regulatory subunit and activating calmodulin binding. (wikipedia.org)
- In addition, comparisons of calcineurin function in both fungi and humans may identify fungal-specific components of calcineurin-signaling pathways that could be targeted for therapy, as well as conserved elements of calcium signaling events. (nih.gov)
- Plasma membrane calcium ATPase isoform 4 inhibits vascular endothelial growth factor-mediated angiogenesis through interaction with calcineurin. (uni.lu)
- Using this reporter, calcineurin activity can be monitored as dephosphorylation-induced increases in fluorescence resonance energy transfer and can be simultaneously imaged with intracellular calcium dynamics. (elsevier.com)
- Calcineurin is a serine/threonine phosphatase involved in a wide range of cellular responses to calcium mobilizing signals. (elsevier.com)
- Furthermore, we show that calcineurin is sensitive to oxidation only when it is in an 'open', calcium-activated conformation, and that G93A-SOD1 must have its redox-active copper site available to substrates in order to exert its pro-oxidant properties on calcineurin. (elsevier.com)
- These results indicate that tacrolimus affects calcium and magnesium transport along the distal convoluted tubule and strongly suggests that inhibition of the phosphatase, calcineurin, is directly involved. (elsevier.com)
- The calcium-activated protein phosphatase, calcineurin, lies at the intersection of protein phosphorylation and calcium signaling cascades, where it provides an essential nodal point for coordination between these two fundamental modes of intracellular communication. (elsevier.com)
- In excitatory cells, such as neurons and cardiomyocytes, that experience rapid and frequent changes in cytoplasmic calcium, calcineurin protein levels are exceptionally high, suggesting that these cells require high levels of calcineurin activity. (elsevier.com)
- Calcineurin is normally a heterotrimeric serine-threonine phosphatase that's made up of a catalytic subunit a regulatory subunit and calmodulin (Rusnak and Mertz 2000 Calcineurin is exclusive among phosphatases for the reason that its activity is normally calcium-dependent and it is central to T-cell receptor (TCR) signaling and amplification of immune system replies. (globaltechbiz.com)
- Calcium regulation of calcineurin phosphatase activity by its B subunit and calmodulin. (elsevier.com)
- A complex of tacrolimus-FKBP-12, calcium, calmodulin, and calcineurin is then formed and the phosphatase activity of calcineurin is inhibited. (nih.gov)
- Calcineurin is a calcium-dependent enzyme involved in the immune system, the regulation of T-cells and also important in the function of heart cells. (cincinnatichildrens.org)
PHOSPHATASE activity of CALCINEURIN3
- Compounds that inhibit or block the PHOSPHATASE activity of CALCINEURIN. (jefferson.edu)
- These data reveal that the success promoting ramifications of CsA and FK-506 on engine neurons following damage are a immediate outcome of their capability to inhibit the phosphatase activity of calcineurin. (happydiwali2014wishesms.org)
- Tacrolimus also inhibits the phosphatase activity of calcineurin . (selleckchem.com)
Developing calcineurin-inhibitor1
- We conclude from our data that the C/D ratio may be an appropriate tool for identifying patients at risk of developing calcineurin-inhibitor toxicity. (uni-muenster.de)
Pimecrolimus and tacrolimus2
- Calcineurin is the target of a class of drugs called calcineurin inhibitors, which include ciclosporin, voclosporin, pimecrolimus and tacrolimus. (wikipedia.org)
- Objective: This commentary is designed to provide a clinical viewpoint regarding the Food and Drug Administration (FDA) and its recent decision to imposed a "black box warning" on the topical calcineurin inhibitors, pimecrolimus and tacrolimus. (cdlib.org)
Role for calcineurin4
- Recent investigations into the molecular mechanisms of pathogenesis in Candida albicans and Cryptococcus neoformans, two fungi that cause life-threatening infections in humans, have revealed an essential role for calcineurin in morphogenesis, virulence, and antifungal drug action. (nih.gov)
- Here we propose a protective role for calcineurin in S63del neuropathy, although Schwann cells appear to be very sensitive to its regulation. (jneurosci.org)
- The paper uncovers a new important role for calcineurin in a demyelinating diseases. (jneurosci.org)
- These findings demonstrate that both wild-type and mutant SOD1s can interfere directly with calcineurin activity and further support the possibility of a relevant role for calcineurin-regulated biochemical pathways in the pathogenesis of FALS. (elsevier.com)
Abstract1
- Abstract: Conversion of kidney-transplant recipients from calcineurin inhibitors to mTOR inhibitors has been suggested to be a risk factor for increased alloimmune response. (unican.es)
Induces2
- Calcineurin induces transcription factors (NFATs) that are important in the transcription of IL-2 genes. (wikipedia.org)
- Tornadic Shear Stress Induces a Transient, Calcineurin-Dependent Hypervirulent Phenotype in Mucorales Molds. (harvard.edu)
FK5068
- Calcineurin is a Ca(2+)/calmodulin-activated protein phosphatase that is conserved in eukaryotes, from yeast to humans, and is the conserved target of the immunosuppressive drugs cyclosporin A (CsA) and FK506. (nih.gov)
- Genetic studies in yeast and fungi established the molecular basis of calcineurin inhibition by the cyclophilin A-CsA and FKBP12-FK506 complexes. (nih.gov)
- Novel non-immunosuppressive analogs of the calcineurin inhibitors CsA and FK506 that retain antifungal activity have been identified and hold promise as candidate antifungal drugs. (nih.gov)
- Detection of the FK506-FKBP-calcineurin complex by a simple binding assay. (semanticscholar.org)
- Charged surface residues of FKBP12 participate in formation of the FKBP12-FK506-calcineurin complex. (semanticscholar.org)
- Here, we demonstrate how calcineurin, when inhibited by immunosuppressive drugs like FK506, is involved in myeloma cell growth and targeted by panobinostat. (jci.org)
- Calcineurin inhibitor tacrolimus (FK506) attenuated the MDI-GSH conjugate-mediated induction of CCL2, CCL3, CCL5, and CXCL8/IL8 but not others. (cdc.gov)
- 2000) that equivalent MPA exposure to that achieved without calcineurin inhibitors was obtained with a 40% reduced dose in combination with FK506, or a 20% increased dose with CsA. (kw-6002.info)
Inhibit calcineurin1
- K09568 ] inhibit calcineurin. (genome.jp)
Observed that calcineurin activity1
- In a recent work, we have observed that calcineurin activity is depressed in two models for familial amyotrophic lateral sclerosis (FALS) associated with mutations of the antioxidant enzyme Cu,Zn superoxide dismutase (SOD1), namely in neuroblastoma cells expressing either SOD1 mutant G93A or mutant H46R and in brain areas from G93A transgenic mice. (elsevier.com)
Treatment with calcineurin inhibitors3
- no scientific evidence of an increased risk for malignancy due to a topical treatment with calcineurin inhibitors. (biomedcentral.com)
- Treatment with calcineurin inhibitors (ciclosporin and tacrolimus) is the standard of care for patients with non-genetic SRNS, and approximately 70% of patients achieve a complete or partial remission and show satisfactory long-term outcome. (thelancet.com)
- Patients with SRNS who do not respond to treatment with calcineurin inhibitors or other immunosuppressive drugs can show declining kidney function and are at risk for end-stage renal failure. (thelancet.com)
Sustained calcineurin activity1
- Finally, we will discuss how circadian oscillations in calcineurin activity may facilitate integration with other essential but conflicting processes, allowing a healthy heart to reap the benefits of calcineurin signaling while avoiding the detrimental consequences of sustained calcineurin activity that can culminate in heart failure. (elsevier.com)
Calmodulin dependent2
- Herein, we report the development of a genetically-encoded protein biosensor designed to specifically probe the activity of the Ca 2+ /calmodulin-dependent protein phosphatase, calcineurin. (elsevier.com)
- The higher potency of the CypB/CsA complex versus CypA/CsA in inhibiting the Ca(2+)- and calmodulin-dependent protein phosphatase calcineurin is discussed in terms of the structural differences between the two complexes. (rcsb.org)
Protein phosphatase 2B1
- Potent calcineurin (protein phosphatase 2B) inhibitor IC 50 ~0.03 nM. (enzolifesciences.com)
Renal transplant1
- Despite therapeutic degrees of tacrolimus and CsA (mean 11.4 and 172 ng/ml) basal calcineurin activity was significantly higher among renal transplant recipients than handles (1776 ± 175 versus 914 ± 78 fmol/μg/min). (globaltechbiz.com)
Test whether calcineurin2
- To test whether calcineurin activity was directly required for Raf activation, we stimulated thymocytes in the presence of the calcineurin inhibitor cyclosporin A (CsA) or the MEK1/2 inhibitor U0126. (gale.com)
- we previously generated mice in which FKBP12 could be deleted along the nephron, to test whether calcineurin inhibition is involved, these mice are normal at baseline. (elsevier.com)
Activation of calcineurin1
- Yet, it is widely recognized that excessive activation of calcineurin in the heart contributes to pathological hypertrophic remodeling and the progression to failure. (elsevier.com)
Withdrawal of calcineurin1
- The most frequent reason for introducing everolimus in maintenance heart transplant patients is to support minimization or withdrawal of calcineurin inhibitor therapy, for example, due to impaired renal function or malignancy. (hindawi.com)
Differences in calcineurin2
- Fundamental differences in calcineurin signaling in neonatal verses adult cardiomyocytes will be addressed as well as the importance of maintaining heterogeneity in calcineurin activity across the myocardium. (elsevier.com)
- The three residues Arg90, Lys113, and Ala128 and the loop containing Arg158 on the surface of CypB are likely to modulate the differences in calcineurin inhibition between CypA and CypB. (rcsb.org)
Tacrolimus and pimecrolimus2
- In the recent past the FDA has elected to modify the labeling of the two topical calcineurin inhibitors, tacrolimus and pimecrolimus, to include a "black box warning" [ 2 ]. (cdlib.org)
- Calcineurin inhibitors (tacrolimus and pimecrolimus) are immunomodulating compounds that act through T-cell modulation. (skintherapyletter.com)
Regulatory subunit1
- Calcineurin is a heterodimer of a 61-kD calmodulin-binding catalytic subunit, calcineurin A and a 19-kD Ca2+-binding regulatory subunit, calcineurin B. There are three isozymes of the catalytic subunit, each encoded by a separate gene (PPP3CA, PPP3CB, and PPP3CC) and two isoforms of the regulatory, also encoded by separate genes (PPP3R1, PPP3R2). (wikipedia.org)
Toxicity5
- Renal calcineurin-inhibitor toxicity is a common adverse effect of tacrolimus therapy. (uni-muenster.de)
- IMSEAR at SEARO: Calcineurin inhibitor toxicity in renal allografts: Morphologic clues from protocol biopsies. (who.int)
- Histological features of calcineurin inhibitor toxicity (CNIT) have been the subject of few studies using protocol biopsy samples, and consensus on diagnostic criteria is still evolving. (who.int)
- 2001 whereas others develop toxicity even KU-60019 though bloodstream trough concentrations are low (Citterio 2004 Kahan 2004 Yet in the lack of an alternative solution method of monitoring calcineurin inhibitor efficiency current treatment protocols continue steadily to trust plasma medication levels for healing monitoring and optimizing immunosuppression. (globaltechbiz.com)
- FKBP12 contributes to a-synuclein toxicity by regulating the calcineurin-dependent phosphoproteome. (harvard.edu)
Steroids4
- Steroids and calcineurin inhibitors (CNI) have been mainstays of immunosuppression but both have numerous side effects that are associated with substantial morbidity and mortality. (notifylibrary.org)
- In the UK, these encompass topical steroids and topical calcineurin inhibitors. (bsaci.org)
- Treatment includes frequent use of moisturisers, and application of mild topical steroids or calcineurin inhibitors (eg. (singhealth.com.sg)
- The most effective way to treat eczema is to use moisturizers and topical ointments that reduce the inflammation e.g. topical steroids or calcineurin inhibitors. (archildrens.org)
Cyclosporin1
- Background: Therapeutic drug monitoring (TDM) of the 2 calcineurin inhibitors (CNIs), tacrolimus (TAC) and cyclosporin A, has resulted in improvements in the management of patients who have undergone solid organ transplantation. (eur.nl)
Inhibits calcineurin2
- Topical tacrolimus inhibits calcineurin, which is related to stimulation by interleukin 2 of T cells. (medscape.com)
- It inhibits calcineurin with an IC 50 of 10 µM using [ 32 P]myosin light chain as substrate. (enzolifesciences.com)
Activity20
- Using mouse genetics including females and males in our experimental setting, we show that PERK and calcineurin interact in P0S63del nerves and that calcineurin activity and NFATc4 nuclear localization are increased in S63del Schwann cells, without altering EGR2/KROX20 expression. (jneurosci.org)
- Moreover, genetic manipulation of the calcineurin subunits appears to be either protective or toxic in S63del in a context-dependent manner, suggesting that Schwann cells are highly sensitive to alterations of calcineurin activity. (jneurosci.org)
- Schwann cells expressing the S63del mutation in P0 protein induce the unfolded protein response and upregulate calcineurin activity. (jneurosci.org)
- Inhibits Mn 2+ -stimulated calcineurin activity but has no effect on Ni 2+ -stimulated activity. (enzolifesciences.com)
- double-positive thymocytes lack calcineurin activity, fail to dephosphorylate NFATc transcription factors and are not positively selected (Fig. 1a and ref. 3). (gale.com)
- Our reporter design utilizes a phosphatase activity-dependent molecular switch based on the N-terminal regulatory domain of the nuclear factor of activated T-cells as a specific substrate of calcineurin, sandwiched between cyan fluorescent protein and yellow fluorescent protein. (elsevier.com)
- Newman, RH & Zhang, J 2008, ' Visualization of phosphatase activity in living cells with a FRET-based calcineurin activity sensor ', Molecular BioSystems , vol. 4, no. 6, pp. 496-501. (elsevier.com)
- Activity of KU-60019 both organizations was comparably inhibited by 5 ng/ml tacrolimus (27 ± 4 versus 30 ± 4 Calcineurin can be a KU-60019 downstream focus on from the KU-60019 T-cell receptor (TCR). (globaltechbiz.com)
- On the other hand anti-CD3/Compact disc28 antibodies didn't stimulate calcineurin activity in transplant topics. (globaltechbiz.com)
- These data claim that study of TCR-stimulated calcineurin activity after renal transplantation could be helpful for monitoring immunosuppression of specific patients. (globaltechbiz.com)
- One potential option to plasma medication level monitoring is normally immediate assay of calcineurin activity. (globaltechbiz.com)
- Nevertheless few studies have got directly analyzed calcineurin activity in T cells or looked into the consequences of calcineurin inhibitors on enzyme activity. (globaltechbiz.com)
- 1997) Mouse monoclonal to Tyk2 utilized a 32 calcineurin-specific substrate to gauge the ramifications of CsA on calcineurin activity in 30 renal allograft recipients. (globaltechbiz.com)
- In vivo measurements showed that calcineurin activity was inhibited by up to 80% 1 h after an dental dosage of CsA but just 20 to 30% within 4 h. (globaltechbiz.com)
- 1994) analyzed the long-term aftereffect of CsA on calcineurin activity in peripheral lymphocytes from bone tissue marrow transplant sufferers. (globaltechbiz.com)
- Although CsA originally inhibited calcineurin activity through the initial 100 times of transplantation enzyme activity steadily rose as time passes and within six months was very similar compared to that of nontransplant handles. (globaltechbiz.com)
- Calcineurin inhibitors are ointments or creams that reduce the activity of the immune system. (hse.ie)
- Moreover, pretreatment with calcineurin auto-inhibitory peptide (CNI) abolished the FSHCTGFβ1-upregulated but not FSH-upregulated aromatase activity at 48 h, and the corresponding mRNA changes in Cyp19a1, and Nr5a2 and Nr5a1 at 24 h. (nycu.edu.tw)
- The protein shares similarity with calcineurin B and calmodulin and it is also known to be an endogenous inhibitor of calcineurin activity. (genetex.com)
- PP2A is distinguishable from PP2B/Calcineurin and PP2C by its partial activity in the absence of divalent cations, and by its high sensitivity to inhibition by okadaic acid. (sigmaaldrich.com)
Regulation3
- After identified the candidate mediators can be regulated by MDI-exposure, we investigated the roles of miR-mediated calcineurin signaling in regulation of these candidate mediators' expressions in relation to the exposure to MDI. (cdc.gov)
- however, whether PPP3CA/calcineurin signalling participates in regulation of other asthma -associated mediators secreted by macrophages/BALCs after MDI exposure is unknown. (cdc.gov)
- This study explored the role of calcineurin and CRTC2 in FSH and TGFβ1 regulation of Cyp19a1 expression in granulosa cells. (nycu.edu.tw)
CNIs2
- Calcineurin inhibitors (CNIs) are immunosuppressive drugs used to prevent graft rejection after organ transplant. (elsevier.com)
- Notably, calcineurin inhibitors (CNIs) have proved to be nephrotoxic and they further increased the already high risk of cardiovascular events among patients with diabetes [6]. (scirp.org)
Immunosuppressive1
- Calcineurin inhibitors (CNI) are an important component of most immunosuppressive protocols utilized in renal transplantation. (elsevier.com)
PPP3CA1
- mRNA expression of PPP3CA , a catalytic subunit of calcineurin, was high in advanced patients. (jci.org)
Graft versus2
- To date, graft versus host disease and calcineurin inhibitor effects on AKI are not well defined. (asnjournals.org)
- A calcineurin inhibitor and mycophenolate mofetil were used for graft-versus-host-disease (GVHD) prophylaxis. (scinfo.org)
Immunosuppression2
- Whereas the data are robust suggesting that high, sustained, systemic daily doses of these agents may pose cancer risks for both humans and animals, there is no demonstrated effect for either topical calcineurin inhibitor in terms of ability to respond to immunizations, infections, or any sign of immunosuppression [ 4 ]. (cdlib.org)
- Unless there are special considerations to take into account, all de novo heart transplant patients can be regarded as potential candidates for immunosuppression with everolimus and reduced-exposure calcineurin inhibitor therapy. (hindawi.com)
Nuclear1
- Calcineurin activates nuclear factor of activated T cell cytoplasmic (NFATc), a transcription factor, by dephosphorylating it. (wikipedia.org)
Virulence1
- Comparison of the roles of calcineurin in physiology and virulence in serotype D and serotype A strains of Cryptococcus neoformans. (duke.edu)
Cytoplasmic1
- Potential targets of therapeutic intervention include the cytoplasmic phosphatase calcineurin and small guanosine triphosphate-binding proteins, such as Rac1 and RhoA, all of which have been implicated in maladaptive hypertrophy. (tamu.edu)
Dephosphorylation1
- Using primary cultures of ovarian granulosa cells from gonadotropin-primed immature rats, we have recently discovered that pituitary FSH and ovarian cytokine transforming growth factor beta 1 (TGFβ1) induce calcineurin-mediated dephosphorylation-activation of cAMP-response element-binding protein (CREB)-regulated transcription coactivator (CRTC2) to modulate the expression of Star, Cyp11a1, and Hsd3b leading to increased production of progesterone. (nycu.edu.tw)
Signal Transduction1
- Our results suggest that CrzA is an important downstream effector of calcineurin that controls morphology in A. fumigatus, but additional downstream effectors that mediate calcineurin signal transduction are likely present in this opportunistic fungal pathogen. (duke.edu)
Transcription1
- In summary, the results of this study indicate that calcineurin and CRTC2 have important roles in mediating FSH and TGFβ1 collateral upregulation of Cyp19a1 expression together with its transcription regulators Nr5a2 and Nr5a1 in ovarian granulosa cells. (nycu.edu.tw)
Pathways1
- Enhancement in neuronal survival is not mediated calcineurin-independent signalling pathways Due to the array of potential cellular interaction focuses on for both FK-506 and CsA, several possible systems of neuronal success results exist beyond that of calcineurin inhibition. (happydiwali2014wishesms.org)
Regulates2
Immune system2
- Calcineurin inhibitors such as tacrolimus are used to suppress the immune system in organ allotransplant recipients to prevent rejection of the transplanted tissue. (wikipedia.org)
- It is a calcineurin inhibitor that changes the immune system to help control lupus symptoms. (mayoclinic.org)