Calcifediol: The major circulating metabolite of VITAMIN D3. It is produced in the LIVER and is the best indicator of the body's vitamin D stores. It is effective in the treatment of RICKETS and OSTEOMALACIA, both in azotemic and non-azotemic patients. Calcifediol also has mineralizing properties.Monomethylhydrazine: Hydrazine substituted by one methyl group.Ligands: A molecule that binds to another molecule, used especially to refer to a small molecule that binds specifically to a larger molecule, e.g., an antigen binding to an antibody, a hormone or neurotransmitter binding to a receptor, or a substrate or allosteric effector binding to an enzyme. Ligands are also molecules that donate or accept a pair of electrons to form a coordinate covalent bond with the central metal atom of a coordination complex. (From Dorland, 27th ed)Pharmacology: The study of the origin, nature, properties, and actions of drugs and their effects on living organisms.Pharmacology, Clinical: The branch of pharmacology that deals directly with the effectiveness and safety of drugs in humans.RNA, Guide: Small kinetoplastid mitochondrial RNA that plays a major role in RNA EDITING. These molecules form perfect hybrids with edited mRNA sequences and possess nucleotide sequences at their 5'-ends that are complementary to the sequences of the mRNA's immediately downstream of the pre-edited regions.Drug Information Services: Services providing pharmaceutic and therapeutic drug information and consultation.Medical Assistance: Financing of medical care provided to public assistance recipients.Uncompensated Care: Medical services for which no payment is received. Uncompensated care includes charity care and bad debts.Beneficence: The state or quality of being kind, charitable, or beneficial. (from American Heritage Dictionary of the English Language, 4th ed). The ethical principle of BENEFICENCE requires producing net benefit over harm. (Bioethics Thesaurus)Voluntary Health Agencies: Non-profit organizations concerned with various aspects of health, e.g., education, promotion, treatment, services, etc.Teaching Materials: Instructional materials used in teaching.Glucose: A primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. It is used therapeutically in fluid and nutrient replacement.Exocytosis: Cellular release of material within membrane-limited vesicles by fusion of the vesicles with the CELL MEMBRANE.Arterioles: The smallest divisions of the arteries located between the muscular arteries and the capillaries.Vasodilation: The physiological widening of BLOOD VESSELS by relaxing the underlying VASCULAR SMOOTH MUSCLE.Insulin: A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1).Stress, Mechanical: A purely physical condition which exists within any material because of strain or deformation by external forces or by non-uniform thermal expansion; expressed quantitatively in units of force per unit area.Osteosclerosis: An abnormal hardening or increased density of bone tissue.Methylprednisolone: A PREDNISOLONE derivative with similar anti-inflammatory action.Pulse Therapy, Drug: Administration of high doses of pharmaceuticals over short periods of time.Bone and Bones: A specialized CONNECTIVE TISSUE that is the main constituent of the SKELETON. The principle cellular component of bone is comprised of OSTEOBLASTS; OSTEOCYTES; and OSTEOCLASTS, while FIBRILLAR COLLAGENS and hydroxyapatite crystals form the BONE MATRIX.Hepatitis C: INFLAMMATION of the LIVER in humans caused by HEPATITIS C VIRUS, a single-stranded RNA virus. Its incubation period is 30-90 days. Hepatitis C is transmitted primarily by contaminated blood parenterally, and is often associated with transfusion and intravenous drug abuse. However, in a significant number of cases, the source of hepatitis C infection is unknown.Antiviral Agents: Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly.Liposomes: Artificial, single or multilaminar vesicles (made from lecithins or other lipids) that are used for the delivery of a variety of biological molecules or molecular complexes to cells, for example, drug delivery and gene transfer. They are also used to study membranes and membrane proteins.Calcitriol: The physiologically active form of vitamin D. It is formed primarily in the kidney by enzymatic hydroxylation of 25-hydroxycholecalciferol (CALCIFEDIOL). Its production is stimulated by low blood calcium levels and parathyroid hormone. Calcitriol increases intestinal absorption of calcium and phosphorus, and in concert with parathyroid hormone increases bone resorption.Pseudomonas aeruginosa: A species of gram-negative, aerobic, rod-shaped bacteria commonly isolated from clinical specimens (wound, burn, and urinary tract infections). It is also found widely distributed in soil and water. P. aeruginosa is a major agent of nosocomial infection.Aerosols: Colloids with a gaseous dispersing phase and either liquid (fog) or solid (smoke) dispersed phase; used in fumigation or in inhalation therapy; may contain propellant agents.Tracheal DiseasesSurface Properties: Characteristics or attributes of the outer boundaries of objects, including molecules.Newspapers: Publications printed and distributed daily, weekly, or at some other regular and usually short interval, containing news, articles of opinion (as editorials and letters), features, advertising, and announcements of current interest. (Webster's 3d ed)Urology: A surgical specialty concerned with the study, diagnosis, and treatment of diseases of the urinary tract in both sexes, and the genital tract in the male. Common urological problems include urinary obstruction, URINARY INCONTINENCE, infections, and UROGENITAL NEOPLASMS.Mass Media: Instruments or technological means of communication that reach large numbers of people with a common message: press, radio, television, etc.Nephrology: A subspecialty of internal medicine concerned with the anatomy, physiology, and pathology of the kidney.Television: The transmission and reproduction of transient images of fixed or moving objects. An electronic system of transmitting such images together with sound over a wire or through space by apparatus that converts light and sound into electrical waves and reconverts them into visible light rays and audible sound. (From Webster, 3rd ed)Kidney: Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.Urology Department, Hospital: Hospital department responsible for the administration and provision of diagnostic and therapeutic services for the urologic patient.Climatotherapy: Relocating a patient to a CLIMATE more suitable for health or for management of a health condition.Endometriosis: A condition in which functional endometrial tissue is present outside the UTERUS. It is often confined to the PELVIS involving the OVARY, the ligaments, cul-de-sac, and the uterovesical peritoneum.Ovarian Diseases: Pathological processes of the OVARY.PubMed: A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.Vitamin D: A vitamin that includes both CHOLECALCIFEROLS and ERGOCALCIFEROLS, which have the common effect of preventing or curing RICKETS in animals. It can also be viewed as a hormone since it can be formed in SKIN by action of ULTRAVIOLET RAYS upon the precursors, 7-dehydrocholesterol and ERGOSTEROL, and acts on VITAMIN D RECEPTORS to regulate CALCIUM in opposition to PARATHYROID HORMONE.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.Vitamin D Deficiency: A nutritional condition produced by a deficiency of VITAMIN D in the diet, insufficient production of vitamin D in the skin, inadequate absorption of vitamin D from the diet, or abnormal conversion of vitamin D to its bioactive metabolites. It is manifested clinically as RICKETS in children and OSTEOMALACIA in adults. (From Cecil Textbook of Medicine, 19th ed, p1406)BooksPublishing: "The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.Pamphlets: Printed publications usually having a format with no binding and no cover and having fewer than some set number of pages. They are often devoted to a single subject.Drug Labeling: Use of written, printed, or graphic materials upon or accompanying a drug container or wrapper. It includes contents, indications, effects, dosages, routes, methods, frequency and duration of administration, warnings, hazards, contraindications, side effects, precautions, and other relevant information.Anti-Anxiety Agents: Agents that alleviate ANXIETY, tension, and ANXIETY DISORDERS, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions. ADRENERGIC BETA-ANTAGONISTS are commonly used in the symptomatic treatment of anxiety but are not included here.Patient Education as Topic: The teaching or training of patients concerning their own health needs.Formularies as Topic: Works about lists of drugs or collections of recipes, formulas, and prescriptions for the compounding of medicinal preparations. Formularies differ from PHARMACOPOEIAS in that they are less complete, lacking full descriptions of the drugs, their formulations, analytic composition, chemical properties, etc. In hospitals, formularies list all drugs commonly stocked in the hospital pharmacy.Diazepam Binding Inhibitor: An 86-amino acid polypeptide, found in central and peripheral tissues, that displaces diazepam from the benzodiazepine recognition site on the gamma-aminobutyric acid receptor (RECEPTORS, GABA). It also binds medium- and long-chain acyl-CoA esters and serves as an acyl-CoA transporter. This peptide regulates lipid metabolism.

Calcium absorption and kinetics are similar in 7- and 8-year-old Mexican-American and Caucasian girls despite hormonal differences. (1/553)

To assess the possibility of ethnic differences in mineral metabolism in prepubertal children, we compared measures of calcium metabolism in 7- and 8-y-old Mexican-American (MA) and non-Hispanic Caucasian (CAU) girls (n = 38) living in southeastern Texas. We found similar fractional calcium absorption, urinary calcium excretion, calcium kinetic values and total-body bone mineral content in the MA and CAU girls. In contrast, parathyroid hormone (PTH) concentrations were greater in MA girls (4.01 +/- 0.47 vs. 1. 96 +/- 0.50 pmol/L, P = 0.005) than in CAU girls. Serum 25-hydroxyvitamin D concentrations were lower in MA girls (68.9 +/- 7.7 vs. 109.4 +/- 8.4 nmol/L, P = 0.001) than in CAU girls, but 1, 25-dihydroxyvitamin D concentrations did not differ between groups. Seasonal variability was seen for 25-hydroxyvitamin D concentrations in girls of both ethnic groups, but values in all of the girls were >30 nmol/L (12 ng/mL). We conclude the following: 1) greater PTH levels in MA girls than CAU girls are present without evidence of vitamin D deficiency; and 2) differences in 25-hydroxyvitamin D and PTH concentrations between MA and CAU girls do not have a large effect on calcium absorption, excretion or bone calcium kinetics. These data do not provide evidence for adjusting dietary recommendations for mineral or vitamin D intake by MA girls.  (+info)

Enzymatic properties of mouse 25-hydroxyvitamin D3 1 alpha-hydroxylase expressed in Escherichia coli. (2/553)

Renal 25-hydroxyvitamin D3 1 alpha-hydroxylase cDNA cloned from the kidneys of mice lacking the vitamin D receptor was expressed in Escherichia coli JM109. As expected, the bacterially-expressed enzyme catalyzes the 1 alpha-hydroxylation of 25-hydroxyvitamin D3 with a Michaelis constant, K(m), value of 2.7 microM. Unexpectedly, the enzyme also hydroxylates the 1 alpha-position of 24,25-dihydroxyvitamin D3 with a K(m) of 1.3 microM, and a fourfold higher Vmax/K(m) compared with the 25-hydroxyvitamin D3 hydroxylase activity, suggesting that 24,25-dihydroxyvitamin D3 is a better substrate than 25-hydroxyvitamin D3 for 1 alpha-hydroxylase. In addition, the enzyme showed 1 alpha-hydroxylase activity toward 24-oxo-25-hydroxyvitamin D3. However, it showed only slight activity towards 23,25-dihydroxyvitamin D3 and 24-oxo-23,25-dihydroxyvitamin D3, and no detectable activity towards vitamin D3 and 24,25,26,27-tetranor-23-hydroxyvitamin D3. These results suggest that the 25-hydroxyl group of vitamin D3 is essential for the 1 alpha-hydroxylase activity and the 24-hydroxyl group enhances the activity, but the 23-hydroxyl group greatly reduced the activity. Another remarkable finding is that living recombinant E. coli cells can convert the substrates into the 1 alpha-hydroxylated products, suggesting the presence of a redox partner of 1 alpha-hydroxylase in E. coli cells.  (+info)

Specific 1,25(OH)2D3-mediated regulation of transcellular calcium transport in Caco-2 cells. (3/553)

Calcium transport in the apical-to-basolateral (A-to-B) or B-to-A direction was examined in cells treated with 10 nM 1, 25-dihydroxyvitamin D3 [1,25(OH)2D3, calcitriol] for up to 72 h. Net A-to-B calcium transport was positive at all time points and increased from 0.14 +/- 0.06 to 0.50 +/- 0.01 nmol. well-1. min-1 after 72 h of calcitriol treatment. Neither phenol red transport nor transepithelial electrical resistance was altered by calcitriol treatment, suggesting that the increase in net A-to-B calcium transport was not due to paracellular movement. Neither 25-hydroxyvitamin D3 nor 24,25-dihydroxyvitamin D3 (100 nM, 48 h) alters basal or calcitriol-stimulated A-to-B calcium transport. Treatment with the calmodulin antagonist trifluoperazine (50 microM) reduced calcitriol-stimulated A-to-B Ca transport by 56%. The transcription inhibitor actinomycin D inhibited calcitriol-regulated A-to-B calcium transport as well as calbindin D9k and 24-hydroxylase mRNA accumulation. These data demonstrate that calcitriol-mediated A-to-B calcium transport in Caco-2 cells is a specific, transcellular process that requires transcriptional events normally mediated through the vitamin D receptor.  (+info)

Serum vitamin D levels and incident changes of radiographic hip osteoarthritis: a longitudinal study. Study of Osteoporotic Fractures Research Group. (4/553)

OBJECTIVE: The purpose of this study was to determine the relationship of serum levels of 25-vitamin D and 1,25-vitamin D to incident changes of radiographic hip osteoarthritis (OA) among elderly white women. METHODS: Baseline and followup hip radiographs of 237 subjects were obtained an average of 8 years apart. Hips were scored for individual radiographic features (IRF) and assigned a summary grade based on the number and type of IRF present. Serum 25- and 1,25-vitamin D levels from baseline samples were analyzed by radioimmunoassay. Logistic and linear regression were used to examine the association of 25- and 1,25-vitamin D levels with radiographic changes, adjusting for age, health status, physical activity, weight, vitamin D supplement use, and calcaneal bone mineral density. RESULTS: The risk of incident hip OA defined as the development of definite joint space narrowing was increased for subjects who were in the middle (odds ratio [OR] 3.21, 95% confidence interval [95% CI] 1.06, 9.68) and lowest (OR 3.34, 95% CI 1.13, 9.86) tertiles for 25-vitamin D compared with subjects in the highest tertile. Vitamin D levels were not associated with incident hip OA defined as the development of definite osteophytes or new disease according to the summary grade. No association between serum 1,25-vitamin D and changes in radiographic hip OA was found. CONCLUSION: Low serum levels of 25-vitamin D may be associated with incident changes of radiographic hip OA characterized by joint space narrowing.  (+info)

Autocrine control of vitamin D metabolism in synovial cells from arthritic patients. (5/553)

OBJECTIVE: This study was designed to investigate whether 1, 25-dihydroxyvitamin D3 (1,25-(OH)2D3), produced by activated synovial fluid macrophages, promotes its own catabolism by upregulating vitamin D-24-hydroxylase (24-OHase) in synovial fibroblasts through a vitamin D receptor (VDR) mediated mechanism. METHODS: Synovial macrophages and fibroblasts were derived from patients with rheumatoid arthritis. Expression of VDR and 24-OHase mRNAs was determined using in situ hybridisation. Vitamin D hydroxylase activity was determined by incubating cells with [3H]-25-(OH)D3, or [3H]-1,25-(OH)2D3, and metabolite synthesis quantified using high performance liquid chromatography. RESULTS: 1, 25-(OH)2D3 increased expression of mRNA for both VDR and 24-OHase in fibroblasts by approximately threefold over 24 hours. 1,25-(OH)2D3 increased fibroblast 24-OHase activity, yielding 24-hydroxylated, and more polar, metabolites. In co-culture, fibroblasts were able to catabolise macrophage derived 1,25-(OH)2D3. CONCLUSIONS: 1, 25-(OH)2D3 is produced by macrophages in vitro at biologically relevant concentrations and can increase its own catabolism by synovial fibroblasts; this effect is probably mediated via upregulation of both synovial fibroblast VDR and 24-OHase.  (+info)

Is low plasma 25-(OH)vitamin D a major risk factor for hyperparathyroidism and Looser's zones independent of calcitriol? (6/553)

BACKGROUND: Recent reports suggest that calcitriol might not be the sole active metabolite of vitamin D and that plasma concentrations of 25-(OH)vitamin D (25OHD) are often abnormally low in hemodialysis patients. We have therefore evaluated plasma 25OHD as a risk factor for parathyroid hormone (PTH) hypersecretion and radiological bone disease. We carried out a cross-sectional study during the month of September in an Algerian dialysis center of 113 patients who were not taking supplements of alphacalcidol or calcitriol. METHODS: Plasma 25OHD, calcitriol, PTH, calcium, phosphate, bicarbonate, and aluminum were measured, and x-rays of the hands and pelvis were obtained for evaluation of subperiosteal resorption and Looser's zones. RESULTS: The median plasma 25OHD was 47.5 nmol/liter (range 2.5 to 170.0). Univariate analysis showed that plasma PTH was correlated positively with months on maintenance dialysis and negatively with plasma 25OHD, calcitriol, calcium, bicarbonate and aluminum, but not with that of phosphate. plasma 25OHD was positively correlated with calcium and calcitriol. Using multiple regression analysis, only plasma 25OHD (negative) and the duration on maintenance dialysis (positive) were independently linked to plasma PTH. The prevalence of isolated subperiosteal resorption (ISR) was 34%, and that of the combination of resorption with Looser's zones (CRLZ) was 9%; thus, only 57% of the patients had a normal x-ray appearance. These groups were comparable with regards to age, gender, and duration on dialysis. When the biochemical measurements of the patients with CRLZ were compared with those from patients without radiological lesions, plasma 25OHD was the only parameter to show a statistically significant difference, being significantly lower in the CRLZ group (26 +/- 18 vs. 57 nmol/liter, ANOVA, P < 0.004). Plasma 25OHD was also significantly lower in the ISR group (44, P < 0.05) than in the normal x-ray group, and plasma Ca (P < 0.003) and bicarbonate (P < 0.02) were lower. Logistical analysis showed that the presence of resorption was independently linked only with plasma PTH. Looser's zones and subperiosteal resorption were not seen in patients with plasma 25OHD of more than 40 (Looser's zones) and more than 100 nmol/liter (subperiosteal resorption). The optimal range for intact PTH in hemodialysis patients with mild aluminum overload is 10 to 25 pmol/liter. We found that plasma PTH was inappropriately high only when plasma 25OHD was less than 100 nmol/liter. With a plasma 25OHD of between 100 and 170 nmol/liter, hypercalcemia was present with a plasma PTH of less than 10 pmol/liter in only one case. CONCLUSIONS: This cross sectional study shows that low plasma 25OHD is a major risk factor for hyperparathyroidism and Looser's zones. In dialysis patients, we suggest that the plasma levels of 25OHD are maintained around the upper limit of the reference range of sunny countries.  (+info)

Tissue engineering of a bioartificial renal tubule assist device: in vitro transport and metabolic characteristics. (7/553)

BACKGROUND: Current renal substitution therapy for acute or chronic renal failure with hemodialysis or hemofiltration is life sustaining, but continues to have unacceptably high morbidity and mortality rates. This therapy is not complete renal replacement therapy because it does not provide active transport nor metabolic and endocrinologic functions of the kidney, which are located predominantly in the tubular elements of the kidney. METHODS: To optimize renal substitution therapy, a bioartificial renal tubule assist device (RAD) was developed and tested in vitro for a variety of differentiated tubular functions. High-flux hollow-fiber hemofiltration cartridges with membrane surface areas of 97 cm2 or 0. 4 m2 were used as tubular scaffolds. Porcine renal proximal tubule cells were seeded into the intraluminal spaces of the hollow fibers, which were pretreated with a synthetic extracellular matrix protein. Attached cells were expanded in the cartridge as a bioreactor system to produce confluent monolayers containing up to 1.5 x 109 cells (3. 5 x 105 cells/cm2). Near confluency was achieved along the entire membrane surface, with recovery rates for perfused inulin exceeding 97 and 95% in the smaller and larger units, respectively, compared with less than 60% recovery in noncell units. RESULTS: A single-pass perfusion system was used to assess transport characteristics of the RADs. Vectorial fluid transport from intraluminal space to antiluminal space was demonstrated and was significantly increased with the addition of albumin to the antiluminal side and inhibited by the addition of ouabain, a specific inhibitor of Na+,K+-ATPase. Other transport activities were also observed in these devices and included active bicarbonate transport, which was decreased with acetazolamide, a carbonic anhydrase inhibitor, active glucose transport, which was suppressed with phlorizin, a specific inhibitor of the sodium-dependent glucose transporters, and para-aminohippurate (PAH) secretion, which was diminished with the anion transport inhibitor probenecid. A variety of differentiated metabolic functions was also demonstrated in the RAD. Intraluminal glutathione breakdown and its constituent amino acid uptake were suppressed with the irreversible inhibitor of gamma-glutamyl transpeptidase acivicin; ammonia production was present and incremented with declines in perfusion pH. Finally, endocrinological activity with conversion of 25-hydroxy(OH)-vitamin D3 to 1,25-(OH)2 vitD3 was demonstrated in the RAD. This conversion activity was up-regulated with parathyroid hormone and down-regulated with increasing inorganic phosphate levels, which are well-defined physiological regulators of this process in vivo. CONCLUSIONS: These results clearly demonstrate the successful tissue engineering of a bioartificial RAD that possesses critical differentiated transport, and improves metabolic and endocrinological functions of the kidney. This device, when placed in series with conventional hemofiltration therapy, may provide incremental renal replacement support and potentially may decrease the high morbidity and mortality rates observed in patients with renal failure.  (+info)

Effects of IGF-I on 1,25-dihydroxyvitamin D(3) synthesis by human placenta in culture. (8/553)

The aim of the present study was to assess the effects of insulin-like growth factor I (IGF-I) upon the synthesis of 1, 25-dihydroxyvitamin D(3) [1,25-(OH)(2)D(3)] by human placenta trophoblasts in culture. Cytotrophoblastic cells obtained from normal term human placentae were cultured in Dulbecco's modified Eagle's medium with HEPES and glucose (DMEM-HG) during 72 h and further incubated in serum-free DMEM-F12 in the presence of IGF-I prior to the addition of [(3)H]-25-(OH)D(3) used as a precursor. The results showed that 2 h preincubation time with IGF-I was required for maximal production of [(3)H]-1,25-(OH)(2)D(3). Cultures in the presence of increasing concentrations of IGF-I (0-6.5 nmol/l), added 2 h before incubation with the labelled substrate, resulted in a dose-dependent response increment of [(3)H]-1,25-(OH)(2)D(3) production with a maximal conversion rate at the dose of 2.6 nmol/l. Higher doses of IGF-I did not result in further stimulatory effects. Co-incubations in the presence of cycloheximide significantly (P < 0. 0001) inhibited the IGF-I-mediated effects upon [(3)H]-1, 25-(OH)(2)D(3) production. Identity of putative [(3)H]-1, 25-(OH)(2)D(3) produced by human placenta was confirmed by spectral and receptor binding analysis. These results demonstrate the ability of cultured human syncytiotrophoblast cells to convert 25-(OH)D(3) to 1,25-(OH)(2)D(3) and suggest a local protein-dependent regulatory effect of IGF-I upon this biotransformation.  (+info)

*Calcifediol

At a typical daily intake of vitamin D3, its full conversion to calcifediol takes approximately 7 days. Calcifediol is then ... In medicine, a 25-hydroxy vitamin D (calcifediol) blood test is used to determine how much vitamin D is in the body. The blood ... Calcifediol (INN), also known as calcidiol, 25-hydroxycholecalciferol, or 25-hydroxyvitamin D (abbreviated 25(OH)D), is a ... Other countries often use nmol/L. Multiply ng/mL by 2.5 to convert to nmol/L. Increasing calcifediol levels are associated with ...

*Vitamin D

Low blood calcifediol (25-hydroxy-vitamin D) can result from avoiding the sun. Deficiency results in impaired bone ... Calcifediol is further hydroxylated by the kidneys to form calcitriol (also known as 1,25-dihydroxycholecalciferol), the ... The relationship between serum calcifediol level and all-cause mortality is parabolic. Harm from vitamin D appears to occur at ... Cholecalciferol is converted in the liver to calcifediol (25-hydroxycholecalciferol); ergocalciferol is converted to 25- ...

*Hypervitaminosis D

Calcifediol is implicated in the etiology of atherosclerosis, especially in non-Caucasians. The levels of the active form of ... In contrast, orally administered vitamin D produces rapid hepatic delivery of vitamin D and increases plasma calcifediol. It ... and free calcifediol enters the cell Intake of vitamin D raises the concentration of vitamin D metabolites which exceed DBP ... plasma calcifediol concentrations. Endogenously synthesized vitamin D3 travels mainly with vitamin D-binding protein (DBP), ...

*Hydroxycholecalciferol

... may refer to: 1-Hydroxycholecalciferol (Alfacalcidol) 25-Hydroxycholecalciferol (Calcifediol) 1,25- ...

*Cholecalciferol

It is converted into calcifediol (25-hydroxyvitamin D) by the liver and into calcitriol (1,25-dihydroxyvitamin D) by the kidney ... Hydroxylation in the kidneys of calcifediol to calcitriol by 1-alpha-hydroxylase is tightly regulated: it is stimulated by ... 25-Hydroxyvitamin D3 1-alpha-Hydroxylase, a kidney enzyme that converts calcifediol to calcitriol. Coulston, Ann M.; Boushey, ... Hydroxylation in the endoplasmic reticulum of liver hepatocytes of cholecalciferol to calcifediol (25-hydroxycholecalciferol) ...

*Prehormone

Calcifediol is an example of prehormones which is produced by hydroxylation of vitamin D3 (cholecalciferol) in the liver. ...

*Health effects of sunlight exposure

The only way to quantify adequate levels of vitamin D is with a serum 25(OH)D3 (calcifediol) test. In the United States, serum ...

*Calcitriol

... is the strictly the 1-hydroxylation product of calcifediol (25-OH vitamin D3), derived from cholecalciferol (vitamin ... calcifediol) in the 1-alpha position. The activity of this enzyme is stimulated by PTH. This is an important control point in ...

*ATC code A11

Ergocalciferol A11CC02 Dihydrotachysterol A11CC03 Alfacalcidol A11CC04 Calcitriol A11CC05 Colecalciferol A11CC06 Calcifediol ...

*List of drugs: C-Ca

Calcarb 600 Calci-Chew Calci-Mix Calcibind Calciday-667 calcifediol (INN) Calcijex Calcimar Calcionate Calciparine ...

*Glutathione

Calcitriol (1,25-dihydroxyvitamin D3), the active metabolite of vitamin D3, after being synthesized from calcifediol in the ...

*Bone resorption

... it has been shown that oral administration of vitamin D does not linearly correlate to increased serum levels of calcifediol, ...

*Secondary hyperparathyroidism

Extended Release Calcifediol was recently approved by the FDA as a treatment for secondary hyperparathyroidism (SHPT) in adults ...

*25-Hydroxyvitamin D3 1-alpha-hydroxylase

The enzyme catalyzes the hydroxylation of Calcifediol to calcitriol (the bioactive form of Vitamin D): calcidiol + 2 reduced ...

*Vitamin D (disambiguation)

Blood concentration of calcifediol is considered the best indicator of vitamin D status. vitamin D-related concepts, including ... also known as vitamin D4 Vitamin D5 Calcifediol, also known as calcidiol: 25-hydroxycholecalciferol, or 25-hydroxyvitamin D ( ...

*List of MeSH codes (D10)

... calcifediol MeSH D10.570.938.146.478.387 --- dihydroxycholecalciferols MeSH D10.570.938.146.478.387.300 --- calcitriol MeSH ...

*Vitamin D-binding protein

... calcifediol), and the active hormonal product, 1,25-dihydroxyvitamin D (calcitriol). The major proportion of vitamin D in blood ...

*Frank C. Garland

... study to show that higher levels of Vitamin D coulnd that those with the highest levels of the Vitamin D metabolite Calcifediol ...

*List of MeSH codes (D04)

... calcifediol MeSH D04.808.247.222.159.478.387 --- dihydroxycholecalciferols MeSH D04.808.247.222.159.478.387.300 --- calcitriol ... calcifediol MeSH D04.808.247.808.146.478.387 --- dihydroxycholecalciferols MeSH D04.808.247.808.146.478.387.300 --- calcitriol ... calcifediol MeSH D04.808.812.768.196.478.387 --- dihydroxycholecalciferols MeSH D04.808.812.768.196.478.387.300 --- calcitriol ...
Calcifediol (also known as calcidiol, 25-hydroxycholecalciferol, or 25-hydroxyvitamin D (OH)D) is a prehormone produced in the liver by the enzyme cholecalciferol (vitamin D3). Calcifediol is then converted to calcitriol (1,25-(OH)2D3), which is the active form of vitamin D. The concentration of calcifediol in blood is considered the best indicator of vitamin D status. Researchers hypothesized that vitamin D supplementation would reduce the degree of chronic pain experienced by FMS patients with low levels of calcifediol and also might improve other symptoms. "Low blood levels of calcifediol are especially common in patients with severe pain and fibromyalgia. But although the role of calcifediol in the perception of chronic pain is a widely discussed subject, we lack clear evidence of the role of vitamin D supplementation in fibromyalgia patients," says lead investigator Florian Wepner, MD, of the Department of Orthopaedic Pain Management, Spine Unit, Orthopaedic Hospital, Speising, Vienna, ...
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The IUPHAR/BPS Guide to Pharmacology. calcifediol ligand page. Quantitative data and detailed annnotation of the targets of licensed and experimental drugs.
RAYALDEE (Calcifediol) drug information & product resources from MPR including dosage information, educational materials, & patient assistance.
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... - BellaOnline Nutrition Database - BellaOnline is committed to helping our visitors become healthy and happy. Our BellaOnline Nutrition Database will help you choose the healthiest foods for your chosen lifestyle.
Laminin-332 (Lm332) is a large heterotrimeric glycoprotein that has been identified Calcifediol as a scattering factor a regulator of malignancy invasion as well as a prominent basement membrane component of the skin. practical significance of 450-2 0 followed by data-dependent MS/MS for probably the most intense ions was performed in both Calcifediol positive and negative ion modes as previously reported (29). test with Microsoft Excel was used to compare the two groups. RESULTS and γas explained under "Experimental Methods.??Total ion chromatograms were acquired by Calcifediol solitary mass scans (450-2 0 in positive (Fig. 4values of protonated molecules acquired by Fourier transform ion cyclotron resonance-MS and LAG3 fragment ions in MSspectra. Additional bisected 792 ([HexNAc-Hex-Hex-NAc-HexNAc-OH + H]+) and 938 ([HexNAc-Hex-HexNAc-(dHex-)HexNAc-OH + H]+) in MS/MS and MS/MS/MS spectra. The extracted ion chromatograms of representative bisected and was acquired in the experiment (data not ...
Pancreatic cells are electrically excitable and respond to raised glucose concentrations with bursts of Ca2+ action possibilities credited to the activation of voltage-dependent Ca2+ channels (VDCCs), which leads to the exocytosis of insulin granules. to glucose-evoked depolarization of the membrane … Continue reading →. ...
It it appears that vitamin D has much wider effects than previously recognized, according to researchers at the Buck Institute in northern California. Working
Vitamin D in the diet program or pores and skin synthesis is biologically inactive; enzymatic conversion (hydroxylation) while in the liver and kidney is necessary for activation. As vitamin D can be synthesized in suitable amounts by most mammals subjected to adequate daylight, It is far from A vital dietary element, and so not technically a vitamin.[three] Alternatively it may be regarded as a hormone, with activation from the vitamin D Professional-hormone causing the active kind, calcitriol, which then creates consequences through a nuclear receptor in numerous unique places.[3] Cholecalciferol is transformed within the liver to calcifediol (twenty five-hydroxycholecalciferol); ergocalciferol is transformed to 25-hydroxyergocalciferol ...
3D NUTRITIONQuality is of highest concern to 3D Nutrition which is why we publish the laboratory tests for each and every batch we manufacture on our website. We are also one of the few brands that do not use amino acid spiking to increase the nitrogen content of our whey products which leads to untrue protein readings during laboratory testing. ...
Ergocalciferol is given orally. Ergocalciferol is a form of prehormone which later converted into calcitriol and calcifediol. Calcifediol and calcitriol will increase the absorption of calcium and phosphate from intestine which increase the serum level of
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Vitamin D deficiency (hypovitaminosis D) is typically diagnosed by measuring the blood concentration of the 25-hydroxyvitamin D (Calcifediol, Calcidiol), which is a precursor to the active form of the 1,25-dihydroxy-vitamin D (Calcitriol) compound.. The blood concentration of 25-hydroxy-vitamin D reflects vitamin D produced in the skin as well as vitamin D acquired from the foods and has a relatively long circulating half-life of 15 days. It does not, however, reveal the amount of vitamin D stored in other body tissues and organs (muscles, liver, bones etc).. ...
Results: 70 subjects (86% male, 66% white, mean (SD) CD4 cell count 537.3 (191.5) per mm3) were randomized, of whom 26 (DRV/r) and 31 (Atripla) completed the 48 week study on the allocated treatment. The mean (SD) difference between baseline and week 48 25[OH]D was 5.0 (5.9) ng/mmol for DRV/r and 1.2 (6.0) for Atripla. After adjustment for baseline 25[OH]D and demographics, at week 48 DRV/r monotherapy was associated with a +3.5 (95% CI 0.5, 6.4) ng/mmol increase in 25[OH]D compared to Atripla (p=0.02). Subjects in the DRV/r arm experienced increases in BMD (mean between-arm difference (0.02 [0.003, 0.04] g/cm2 at the lumbar spine, p=0.03, and 0.03 [0.006, 0.06] g/cm2 at the neck of femur, p=0.02), and reductions in parathyroid hormone (PTH) (-20.4 [-38.8, -2.0] ng/l, p=0.03), bone-specific alkaline phosphatase (-7.1 [-9.7, -4.5]) IU/L, p< 0.0001) and serum type 1 pro-collagen (-16.9 [-26.5, -7.4] ug/L, p=0.0008), as compared with subjects on Atripla. No significant difference in RTD (urine ...
The 25-hydroxyvitamin D3 (25-OH-D3) is a nontoxic and low-affinity vitamin D receptor (VDR)-binding metabolic precursor of 1,25-dihydroxyvitamin D3 [1,25(OH)2D3]. We hypothesized that covalent attachment of a 25-OH-D3 analog to the hormone-binding pocket of VDR might convert the latter into transcriptionally active holo-form, making 25-OH-D3 biologically active. Furthermore, it might be possible to translate the nontoxic nature of 25-OH-D3 into its analog. We showed earlier that 25-hydroxyvitamin D3-3bromoacetate (25-OH-D3-3-BE) alkylated the hormonebinding pocket of VDR. In this communication we describe that 10 6 mol/L of 25-OH-D3-3-BE inhibited the growth of keratinocytes, LNCaP, and LAPC-4 androgen-sensitive and PC-3 and DU145 androgen-refractory prostate cancer cells, and PZ-HPV-7 immortalized normal prostate cells with similar or stronger efficacy as 1,25(OH)2D3. But its effect was strongest in LNCaP, PC-3, LAPC-4, and DU145 cells. Furthermore, 25-OH-D3-3-BE was toxic to these prostate cancer
Objective To synthesize mesoporous silica-core-shell magnetic nanoparticles (MNPs) encapsulated by liposomes (Lipo [[email protected] the targeting of breasts malignancy. 10, 11). Finally, using liposomes to encapsulate the coated nanoparticles is usually a well-established method that results in Calcifediol stable behavior in conjunction with a long circulation time. Liposomes can also contain a large number of MNP cores and can, therefore, deliver them undiluted, to the target site (12). In order to increase selectivity and recognition, antibodies targeting malignancy cells can be altered and secured onto the liposome encapsulated nanoparticles. One such ligand, receptor 2 (Her2), has been utilized for this technique. Although Her2/is usually expressed at low levels in normal adult tissues, it is upregulated in approximately 30% of breast cancers and 20% of ovarian cancers (13, 14). Trastuzumab (Her2/expression receptor antibody, Herceptin?, Genentech, Inc., South San Francisco, CA, USA) is usually a ...
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Protein franskbrød nutrition facts and nutritional information. Find calories, carbs, and nutritional contents for Protein franskbrød and over 2,000,000 other foods at MyFitnessPal.com.
To elucidate the biosynthesis of 25-hydroxyvitamin D3-26,23-lactone, two known metabolites of 25-hydroxyvitamin D3--23,25-dihydroxyvitamin D3 and 25,26-dihydroxyvitamin D3--were incubated individually with kidney homogenate prepared from vitamin D-supplemented chickens, a preparation known to produce the lactone from 25-hydroxyvitamin D3. The 25-hydroxyvitamin D3-26,23-lactone produced in vitro was then separated, purified, identified, and quantitated by consecutive straight-phase and reverse-phase high-performance liquid chromatography. 23,25-Dihydroxyvitamin D3 is a far better substrate for production of 25-hydroxyvitamin D3-26,23-lactone than is 25,26-dihydroxyvitamin D3. Production of lactone is highly selective for the natural 23(S)-hydroxy-23,25-dihydroxyvitamin D3 while both epimers of 25,26-dihydroxyvitamin D3 resulted in small amounts of product comigrating with natural lactone. It appears that 23(S),25-dihydroxyvitamin D3, but not 25,26-dihydroxyvitamin D3, is a natural precursor in ...
The present study is one of the few studies investigating vitamin D status in the pediatric population in the southern region of the United States. In particular, this study is the first to address 25-hydroxyvitamin D levels over 4 seasons in a cohort of black and white adolescents living at southern US latitudes. Our data demonstrate that low vitamin D status is common among adolescents residing in the southeastern region and is related to various adiposity and lifestyle factors.. From NHANES III (1988-1994)2 to NHANES 2000-2004,2,24 the prevalence of vitamin D deficiency (25-hydroxyvitamin D levels of ≤50 nmol/L) in black and white adolescents increased from 28% to 48% and that of vitamin D insufficiency (25-hydroxyvitamin D levels of ≤75 nmol/L) increased from 66% to 81%. More importantly, ∼70% of the black adolescents in NHANES 2000-2004 had winter serum vitamin D deficiency, which might have important implications for known health disparities.24 The NHANES provided key information ...
In view of the high incidence of rickets in infants of women practising purdah (the use of veils) in northern Nigeria we conducted a study on plasma calcium, phosphate, and serum 25-hydroxyvitamin D (25 OHD) concentrations in pregnant Nigerian women and in cord blood obtained from the newborns. Plasma calcium, phosphate, and serum 25 OHD concentrations were lower in practising women and their newborns than those not practising purdah and their infants, respectively. The concentrations of 25 OHD in all Nigerian women were greater than those observed in caucasian women in the United Kingdom. These data emphasise the role of exposure to sunshine in regulating serum 25 OHD concentrations and the adverse effect of deliberate exclusion of sunshine and are consistent with previous data indicating hypovitaminosis D in purdah clad women and their newborns in Saudi Arabia. These data do not, however, provide an explanation for the pathogenesis of the high incidence of neonatal rickets and tetany in ...
A number of studies have suggested a link between low levels of vitamin D and higher incidence of chronic pain There is a well-established link between low vitamin D and pain due toosteomalacia. There is no clear biological mechanism of how low We searched Medline (PubMed) using various search terms for vitamin D might be causally related to other types of chronic pain, vitamin D (vitamin D; vitamin D2; vitamin D3; 1-alpha-hydroxyvi- though vitamin D is thought to be involved in regulating inflamma- tamin D3; 1-alpha hydroxycalciferol; 1,25-dihydroxyvitamin D3; tory cytokine synthesis , and might be implicated in some hydroxyvitamin D; alfacalcidol; calcidiol; calcitriol; calcifediol; Associations of pain with latitude and season of the year offer calciferol; ergocalciferol; cholecalciferol; and spelling variations circumstantial evidence that vitamin D may be involved. These thereof) and pain*". The last search was conducted on 8 Septem- associations have been suggested for such diverse ...
Vitamin D is a fundamentally important hormone involved in calcium absorption, bone mineralization and parathyroid hormone production. Vitamin D deficiency may result in a myriad of diseases, such as osteomalacia, rickets and has more recently been identified as a risk factor for diabetes. Accurate determination of serum vitamin D levels is, therefore, paramount when assessing an individual for related pathologies against an appropriate reference range for interpretation. The purpose of this study was to assess vitamin D status between healthy Caucasian and healthy Asian populations of Peterborough, taking into account seasonal serum vitamin D variation. In addition, we evaluated whether a reference range for serum vitamin D of the local population should be race and/or seasonal specific. Using a Chromsystems high-pressure liquid chromatography vitamin D2/D3 methodology upon Agilent 1100 hardware, serum vitamin D status was assessed in 200 subjects of varying age, gender and ethnicity using ...
By Mark, Sean Gray-Donald, Katherine; Delvin, Edgard E; OLoughlin, Jennifer; Paradis, Gilles; Levy, Emile; Lambert, Marie BACKGROUND: Adequate vitamin D status is important for bone growth and mineralization and has been implicated in the regulation of autoimmunity, metabolic function, and cancer prevention. There are no reports of population-based studies on the vitamin D status of Canadian youth, a population with mandatory fortification of foods. METHODS: We measured plasma 25-hydroxyvitamin D [25(OH)D], the best indicator of vitamin D status, in a school-based cross- sectional sample of representative French Canadian youth (n = 1753) ages 9, 13, and 16 years living in Quebec (latitude: 45[degrees]- 48[degrees]N). Blood samples were collected from January to May 1999. We defined 25(OH)D deficiency as =27.5 nmol/L, hypovitaminosis as =37.5 nmol/L, and optimal as ,75.0 nmol/L. RESULTS: More than 93% of youth in each age and sex group had suboptimal 25(OH)D concentrations. The prevalence of ...
Smokers with low vitamin D concentrations had a higher risk of developing diabetes during their pregnancy than did nonsmokers with adequate vitamin D levels. Both smoking and having low vitamin D levels put women at a greater risk than either risk factor alone. The researchers concluded more investigation is needed to confirm their results and study the interactive effect of smoking and low vitamin D levels.A total of 20 ng/ml (nanograms/milliliter) to 50 ng/ml of vitamin D is considered an average blood level. If the level falls below 12 ng/ml, it is seen as deficient. Vitamin D deficiency could have been what Charles Dickens had in mind when he created Tiny Tim crippled. A deficiency of the vitamin causes rickets in children and osteomalacia in adults: bones can become brittle, thin, or misshapen.. Fortunately, both human skin and mushrooms make vitamin D when exposed to sunlight. So mothers can take in their vitamin D naturally from being outdoors for a few minutes a day without sunscreen, or ...
title: Relationship between vitamin D-binding protein polymorphisms and blood vitamin D level in Korean patients with COPD., doi: 10.2147/COPD.S96985, category: Article
Osteopathic Medicine;Vitamin D-Binding Protein;Vitamin D Deficiency;Vitamin D;Hypercalcemia;S100 Calcium Binding Protein G;Bone Diseases;Calbindins;Calcifediol;Calcification, Physiologic;Gene Targeting;Hyperparathyroidism;Parathyroid Hormone;RNA ...
To date, 31 cases and 7 controls are enrolled. The mean ± SD case age is 7.2 ± 1.4 years; 55% are male. The mean control age is 6.4 ± 1.3 years; 57% are male. The mean 25-hydroxy vitamin D level for cases is 21.5 ± 7 ng/mL (n=23). This mean is at the cutpoint for vitamin D insufficiency [serum 25-hydroxy vitamin D level,20 ng/mL]. Ten cases (43%) are vitamin D insufficient. The mean 25-hydroxy vitamin D level for controls is 29 ± 3.3 ng/mL (n=4) … ...
We explored the association between vitamin D status and total and specific cancers in the same populations. We found a statistically significant positive association between vitamin D status and the incidence of NMSC. Except for this, there were no statistically significant associations between vitamin D status and total cancer as well as specific cancers in the fully adjusted models. However, the inverse associations between vitamin D status and colorectal cancer and head and neck cancer were statistically and borderline significant, respectively, in the partly adjusted models.. Regarding other general population studies on vitamin D status and total cancer incidence, the results were inconclusive. Ordonez-Mena and colleagues found no statistically significant association between vitamin D status and the incidence of total cancer in a general German population cohort, except in subgroup analyses (23). Thus, there was a significantly increased overall cancer risk for low vitamin D status among ...
The study, presented at the American Society of Anesthesiologists 2007 Annual Meeting in San Francisco, found that one in four patients who suffer from chronic pain also have inadequate blood levels of vitamin D. As such, the researchers put forth that the vitamin D deficiency possibly contributed to the patients ongoing pain. Vitamin D deficiency - which can lead to osteopenia, osteoporosis, muscle weakness, fractures, common cancers, autoimmune diseases, infectious diseases and cardiovascular diseases - s been found to be lacking particularly in inhabitants of colder climates. A recent study, for example, indicated that the median adult intake of vitamin D in the US is only 230 IU per day, versus the researchers recommended 2000 IU per day. The latest study, undertaken at the Mayo Comprehensive Pain Rehabilitation Center in Rochester, Minnesota, involved 267 adults undergoing outpatient treatment for chronic pain. The researchers recorded their serum vitamin D levels, pain medication ...
The influence of vitamin D3 and its metabolites calcifediol (25(OH)D) and calcitriol on immune regulation and inflammation is well described, and raises the question of potential benefit against bacterial infections. In the current study, 25(OH)D was encapsulated in liposomes to enable aerosolisation, and tested for the ability to prevent pulmonary infection by Pseudomonas aeruginosa. Prepared 25(OH)D-loaded liposomes were nanosized and monodisperse, with a negative surface charge and a 25(OH)D entrapment efficiency of approximately 23%. Jet nebulisation of liposomes was seen to yield an aerosol suitable for tracheo-bronchial deposition. Interestingly, 25(OH)D in either liposomes or ethanolic solution had no effect on the release of the proinflammatory cytokine KC from Pseudomonas-infected murine epithelial cells (LA-4); treatment of infected, human bronchial 16-HBE cells with 25(OH)D liposomes however resulted in a significant reduction in bacterial survival. Together with the importance of ...
Vitamin D, either in its D2 or D3 form, is essential for normal human development during intrauterine life, kidney function and bone health. Vitamin D deficiency has also been linked to cancer development and some autoimmune diseases. Given this huge impact of vitamin D on human health, it is important for daily clinical practice and clinical research to have reliable tools to judge on the vitamin D status. The major circulating form of vitamin D3 is 25-hydroxyvitamin D3 (25(OH)D), although is not the most active metabolite, the concentrations of total 25-hydroxy vitamin D3 in the serum are currently routinely used in clinical practice to assess vitamin D status ...
Causes of MS: It is not right to think vitamin D deficiency causes MS, but it seems a healthy level of vitamin D helps to prevent symptoms of MS in some people. There are several reports about this, some clinical trials are in progress. Corticosteroid medicine is often used temporarily to stop relapses of MS. Its effects on vitamin D are not relevant, the benefits of using it for a short time are better. ...Read more See 3 more doctor answers ...
AbstractBackground Poor vitamin D status (i.e. low serum 25-hydroxyvitamin D (25(OH)D)) has been associated with adverse clinical outcomes during pregnancy and childhood. However, the interpretation of serum 25(OH)D levels may be complicated by the presence of the C3-epimer of 25(OH)D. We aimed to quantify C3-epi-25(OH)D3 in pregnant women and fetuses, to explore the relationship of the C3-epimer between maternal and cord samples, and to establish whether infant C3-epimer abundance is explained by prenatal formation. Methods In a sub-study of a randomized trial of prenatal vitamin D3, 25(OH)D3 and C3-epi-25(OH)D3 were quantified by LC-MS/MS in 71 sets of mother-fetus-infant serum samples, including maternal delivery specimens, cord blood, and infant specimens acquired at 3-28 weeks of age. Results Without supplementation, median concentrations of C3-epi-25(OH)D3 were higher in infants (6.80 nmol/L) than mothers (0.45 nmol/L) and cord blood (0 nmol/L). However, there was substantial variation such that
An article published by Time Magazine discusses recent study that found insufficient vitamin D may lead to greater cognitive decline in older adults.
Severe vitamin D deficiency causes the bones to soften and leads to bone disorders. In children, the most visible sign of vitamin D deficiency is bowed arms and legs. In adults, the most common symptom of vitamin D deficiency is generalized bone and muscle pain. ...
Recent evidence shows that low vitamin D status is related to higher risks for hypertension, dyslipidemia, diabetes, obesity, metabolic syndrome (MS), and cardiovascular (CVD) events. Some studies support the association between higher levels of vitamin D and a lower prevalence of cardiometabolic disease, however, this conclusion is not consistent in literature. PURPOSE: To investigate the associations of serum 25-hydroxyvitamin D (25(OH)D) concentration and clustering of risk factors for cardiometabolic disorders. METHODS: A total of 508 men and women (aged 19 to 70 years) from urban areas of Shanghai, China, were investigated. Demographic and anthropometric data were collected, and fasting blood samples were assessed for serum 25(OH)D, blood glucose and lipid concentrations. Participants were statistically grouped into tertiles according to their serum concentration level. Across the tertiles, linear regression analyses were used to evaluate associations between serum 25(OH)D concentration and
ANALYSIS OF PREVALENCE OF VITAMIN D DEFICIENCY IN ADULTS Author: Jana Nováková Supervisor: PharmDr. Eva Zimčíková, PhD. INTRODUCTION Estimated vitamin D deficiency occurs in up to 1/3 of the population. Vitamin D deficiency occurs in a number of diseases and in different countries of the world. AIMS The aim of the theoretical part of the diploma thesis was to get acquainted with vitamin D and its deficit in general. The objective of the practical part was to map vitamin D levels in adults, to assess prevalence of vitamin D deficiency, to determine if vitamin D levels fluctuate over the course of the year depending on age or gender and how they are related to individual illnesses. METHODS PubMed and Embase database search was performed to find evidence on vitamin D deficiency in adults. Only studies in humans, published in English in the period from 2000 to 2016 were included. Non-systematic review was provided, the quality of the studies was not evaluated. RESULTS Overall, 84 studies were ...
Ama : Ya da z nen bir vitamin olan D vitamini kemik ve kalsiyum metabolizmas n n d zenlenmesinde maj r bir rol oynar ve imm n ve kardiovask ler sistem zerinde etkilere sahiptir. D vitamini eksikli i genel populasyonun yan s ra kritik hastalarda da s k g r l r ve morbidite ve mortaliteyi artt rd bildirilmi tir. Bizim amac m z yo un bak m giri indeki D vitamini d zeyi ile mortalite ili kisini ara t rmakt ...
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It has become increasingly recognized that low vitamin D levels are prevalent worldwide and to a more severe degree in the Middle East. Low vitamin D levels are associated with an increased risk of osteoporotic fractures, and of chronic conditions such as autoimmune disorders, diabetes, cancer, and the metabolic syndrome. Obese individuals are more likely to have low vitamin D levels, and in some studies obesity was a risk factor for fractures in both the young and elderly. Our group has investigated the impact of vitamin D therapy in the young, and preliminary data suggest that doses exceeding the currently updated recommended estimated average requirement (EAR) of 400IU for that age group may be more beneficial for bone health. The updated EAR recommendations by the IOM for any age group, although believed to cover the needs of all individuals in each age group, are limited by the lack of good evidence supporting such recommendations. Therefore, to-date, the optimal dose of vitamin D for both ...
It has become increasingly recognized that low vitamin D levels are prevalent worldwide and to a more severe degree in the Middle East. Low vitamin D levels are associated with an increased risk of osteoporotic fractures, and of chronic conditions such as autoimmune disorders, diabetes, cancer, and the metabolic syndrome. Obese individuals are more likely to have low vitamin D levels, and in some studies obesity was a risk factor for fractures in both the young and elderly. Our group has investigated the impact of vitamin D therapy in the young, and preliminary data suggest that doses exceeding the currently updated recommended estimated average requirement (EAR) of 400IU for that age group may be more beneficial for bone health. The updated EAR recommendations by the IOM for any age group, although believed to cover the needs of all individuals in each age group, are limited by the lack of good evidence supporting such recommendations. Therefore, to-date, the optimal dose of vitamin D for both ...
A separate research study examines Vitamin D deficiency and Alzheimers Disease. Scientists speculate that lack of adequate Vitamin D could be one of the causal factors for Alzheimers. Another study (just published) finds an association between cognitive processing speed and administration of Vitamin D ...
Deficiency in vitamin D resulted in breast cancer tumors that grew faster and were more likely to metastasize, according to a recent study using mouse and cell culture models. The study also demonstrated a correlation between serum vitamin D levels and ID1.
Sufficient vitamin D status may be defined as the evolutionary established circulating 25-hydroxyvitamin D [25(OH)D] matching our Paleolithic genome. We studied serum 25(OH)D [defined as 25(OH)D2 + 25
Read about vitamin D deficiency treatment, causes, symptoms, signs, diagnosis, and daily limits chart. Depression, osteoporosis, allergies, and certain cancers have been tied to vitamin D deficiency.
Do You Have A Vitamin D Deficiency? Join 109 friendly people sharing 34 true stories in the I Have a Vitamin D Deficiency group. Find support forums, advice and chat with groups who share this life experience.
The test for a vitamin D deficiency is called the 25(OH)D test and measures the blood level of calcidiol. Test results in the U.S. tend to be in ng/ml.
Recent reports suggest that hypovitaminosis D in athletes is as common as in the general population. This study was devised to examine vitamin D status
ED07-03 Vitamin D insufficiency is now known to be the principal controllable cause of cancer of the colon, breast, and kidney, and is associated with higher incidence of cancer of the ovary, endometrium, several other malignancies, and all cancers as a group, except those mainly due to smoking, alcohol abuse, or long-term complications of viral infection. Insufficiency of vitamin D in childhood is associated with higher risk of prostate cancer. Consistent with this, low serum levels of the principal circulating vitamin D metabolite, 25-hydroxyvitamin D (25(OH)D), are associated with higher incidence and mortality rates from colon, breast, and ovarian cancer. There is a linear, inverse dose-response gradient between 25(OH)D and these cancers (serum levels in ng/ml may be multiplied by 2.5 to obtain nmol/L).. Dose-response relationships for cancers of the kidney, endometrium, and other solid tumors have been estimated from observational studies, a clinical trial, and natural experiments ...
Raising your serum 25-hydroxyvitamin D to 40ng/ml can help slash your risk of invasive cancers by 67 percent over those with low vitamin D levels.
Author: Kristen Bobik. Title: Help Patients Achieve Optimal Vitamin D Levels. Summary: Much research has been done on vitamin D levels and their impact on health; optimal levels have been correlated with a reduced risk of developing...
Here are seven signs and symptoms of vitamin D deficiency -- if you think you have any of these, you should get your vitamin D levels tested sooner.
Emerging research shows a positive link between adequate Vitamin D levels and decreasing the risk of hypertension, stroke and metabolic syndrome. Those who live in climates where sun exposure is limited and the elderly are particularly susceptible to Vitamin D deficiency.
Observational studies suggest low vitamin D status can be associated with an increased risk of dying from conditions such as cancer, cardiovascular disease and diabetes (Autier P, Gandini S, 2007 ...
In a recent study, vitamin D deficiency was associated with emotional, behavioral and peer relationship problems among older adolescents.
Am I imagining this? I never heard of one person in the uk being diagnosed with vitamin d deficiency. Not one my whole life. I know a few people here who e...
Study that looks at Vitamin D deficiency and cognition relationship in older adults adds to the existing literature on the subject.
Cholecalciferol, also called vitamin D-3, is a fat-soluble vitamin that is necessary for the maintenance of a healthy body. Your body makes cholecalciferol when your skin is exposed to ultraviolet rays from the sun, according to MayoClinic.com.
The body does make its own vitamin D-3. Vitamin D-3, also called cholecalciferol, is made in the skin of human beings from a compound called...
However, they added that individuals shouldnt wait until they are hospitalized to start paying attention to their vitamin D levels. Taking steps to improve nutritional status prior to becoming ill may help improve survival when an injury or disease does strike ...
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We all lead our lives in a hurry, pacing forward, trying to get by. This is the modern life and we all feel its consequences. In the process of living we endure massive amounts of stress, we deprive ourselves of Read More …. ...
I was recently diagnosed with VDD - my D3 level was 23 and my D2 was |4. I also have Stein-Leventhal Syndrome (PCOS)...I cant count on both hands how many doctors have tried to give me anti-depressan...
For cancer patients, increased levels of circulating 25-hydroxyvitamin D (25[OH]D) at or near the time of diagnosis are associated with improved outcomes, according to a review.
In this study, data were available with 451 kidney stone cases and 482 controls for the analysis. This work provided convincing evidence that serum vitamin D level in kidney stone patients was significantly higher than that in non-kidney stone controls. The associations were also significant both in Europe and in Asia populations.. In our study, significant between-study heterogeneity was found between serum vitamin D levels and kidney stone risk. Previous paper [21] had reported that heterogeneity is common in the meta-analyses. To explore the potential sources of between-study heterogeneity is therefore an essential component of meta-analysis. The high degree of heterogeneity might have arisen from publication year, study design and geographic locations. Therefore, we used meta-regression to explore the causes of heterogeneity by covariates. However, no covariate had significant impact on the high between-study heterogeneity among those mentioned above. Considering the pooled meta-analysis was ...
Hepatitis C-associated osteosclerosis (HCAO), a very rare disorder in which an extremely rapid bone turnover occurs and results in osteosclerosis, was acknowledged in 1990s as a new clinical entity with the unique bone disorder and definite link to chronic type C hepatitis, although the pathogenesis still remains unknown. Affected patients suffer from excruciating deep bone pains. We report the 19th case of HCAO with diagnosis confirmed by bone biopsy, and treated initially with a bisphosphonate, next with corticosteroids and finally with direct acting antivirals (DAA: sofosbuvir and ribavirin) for HCV infection. Risedronate, 17.5 mg/day for 38 days, did not improve the patients symptoms or extremely elevated levels of bone markers, which indicated hyper-bone-formation and coexisting hyper-bone-resorption in the patient. Next, intravenous methylprednisolone pulse therapy followed by high-dose oral administration of prednisolone evidently improved them. DAA therapy initiated after steroid ...
Hepatitis C-associated osteosclerosis (HCAO), a very rare disorder in which an extremely rapid bone turnover occurs and results in osteosclerosis, was acknowledged in 1990s as a new clinical entity with the unique bone disorder and definite link to chronic type C hepatitis, although the pathogenesis still remains unknown. Affected patients suffer from excruciating deep bone pains. We report the 19th case of HCAO with diagnosis confirmed by bone biopsy, and treated initially with a bisphosphonate, next with corticosteroids and finally with direct acting antivirals (DAA: sofosbuvir and ribavirin) for HCV infection. Risedronate, 17.5 mg/day for 38 days, did not improve the patients symptoms or extremely elevated levels of bone markers, which indicated hyper-bone-formation and coexisting hyper-bone-resorption in the patient. Next, intravenous methylprednisolone pulse therapy followed by high-dose oral administration of prednisolone evidently improved them. DAA therapy initiated after steroid ...
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Previous work has shown that adequate vitamin D nutrition is associated with a lower risk of multiple sclerosis. Results from studies examining whether adequate vitamin D exposure during early-life are also associated with a lower risk of MS have been mixed. One study reported that daughters of mothers with high dietary vitamin D intake during their pregnancy had a reduced risk of multiple sclerosis, while two studies measuring 25-hydroxy vitamin D either in a blood sample from the pregnant mother or from a sample taken from the neonate, were not associated with future multiple sclerosis risk in the child. READ MORE ...
The importance of adequate vitamin D status for optimum bone health has received increased recognition in recent years, with higher recommended intake levels being proposed by some investigators, according to background information in the article. The ideal intake is not known, and different criteria have been proposed for estimating population requirements. Serum 25-hydroxyvitamin D has been the generally accepted indicator of vitamin D status, but no universal consensus has been reached regarding which serum values constitute sufficiency. An inverse relationship between serum 25-hydroxyvitamin D and serum parathyroid hormone (PTH) is well established. Parathyroid hormone is a major hormone maintaining normal serum concentrations of calcium and phosphate and is itself regulated through levels of calcitriol and serum calcium. An insufficiency of vitamin D or calcium is generally associated with an increase in PTH ...
PAB810Mu02, Polyclonal Antibody to Vitamin D Binding Protein (DBP), GC; VDBG; VDBP; Group-Specific Component; Gc-globulin | Products for research use only!
BACKGROUND:. First Nations children are at higher risk for vitamin D deficiency and rickets.. OBJECTIVE:. To assess the prevalence of vitamin D deficiency and the correlations between fat mass, parathyroid hormone and dietary habits with serum vitamin D level in a random sample of Cree children eight to 14 years of age.. METHODS:. Serum 25-hydroxyvitamin D (25[OH]D) levels and additional information regarding anthropometrics and dietary habits were obtained from participants in two Cree communities. Vitamin D deficiency and insufficiency was defined as serum 25(OH)D levels ,30 nmol/L and ,50 nmol/L, respectively.. Proportions to estimate the vitamin D status were weighted to account for the complex sampling design, and Pearsons correlation coefficients were used to estimate the associations of milk and fish intake, parathyroid hormone and fat mass with serum 25(OH)D levels.. RESULTS:. Data from 52 healthy Cree children (mean [± SD] age 11.1±2.0 years; 27 boys) were included in the analyses. ...
Vitamin D Binding Protein antibody (group-specific component (vitamin D binding protein)) for ICC/IF, IHC-P, WB. Anti-Vitamin D Binding Protein pAb (GTX109955) is tested in Human, Mouse samples. 100% Ab-Assurance.
Photochemical synthesis of vitamin D3 (cholecalciferol, D3) occurs cutaneously where pro-vitamin D3 (7-dehydrocholesterol) is converted to pre-vitamin D3 (pre-D3) in response to ultraviolet B (sunlight) exposure. Vitamin D3, obtained from the isomerization of pre-vitamin D3 in the epidermal basal layers or intestinal absorption of natural and fortified foods and supplements, binds to vitamin D-binding protein (DBP) in the bloodstream, and is transported to the liver. D3 is hydroxylated by liver 25-hydroxylases (25-OHase). The resultant 25-hydroxycholecalciferol (25(OH)D3) is 1-hydroxylated in the kidney by 25-hydroxyvitamin D3-1 -hydroxylase (1-OHase). This yields the active secosteroid 1 ,25(OH)2D3 (calcitriol), which has different effects on various target tissues. The synthesis of 1,25(OH)2D3 from 25(OH)D3 is stimulated by parathyroid hormone (PTH) and suppressed by Ca2+, Pi and 1,25(OH)2D3 itself. The rate-limiting step in catabolism is the degradation of 25(OH)D3 and 1,25(OH)2D3 to ...
Background: The mechanism and clinical significance of low circulating 25-hydroxyvitamin D [25(OH)D] in obese people are unknown. Low total 25(OH)D may be due to low vitamin D-binding proteins (DBPs) or faster metabolic clearance. However, obese people have a higher bone mineral density (BMD), which suggests that low 25(OH)D may not be associated with adverse consequences for bone. Objective: We sought to determine whether 1) vitamin D metabolism and 2) its association with bone health differ by body weight. Design: We conducted a cross-sectional observational study of 223 normal-weight, overweight, and obese men and women aged 25-75 y in South Yorkshire, United Kingdom, in the fall and spring. A subgroup of 106 subjects was also assessed in the winter. We used novel techniques, including an immunoassay for free 25(OH)D, a stable isotope for the 25(OH)D3 half-life, and high-resolution quantitative tomography, to make a detailed assessment of vitamin D physiology and bone health. Results: Serum ...
Background Previously reported associations between vitamin D status, as measured by serum 25-hydroxyvitamin D [25(OH)D] concentrations, and cardiometabolic risk factors were largely limited by...
There may be a strong relationship between lower rates of vitamin D3 in blood and a variety of chronic diseases.1 An objective review is still necessary for the clinician to separate fact from fiction regarding this specific vitamin.2 Vitamin D deficiency has negative effects across the lifespan.3 Vitamin D is a fat-soluble vitamin that is metabolized by the body by either sun (ultraviolet light) exposure or dietary intake and its metabolism is well understood.4,5 Both vitamin D from the sun and diet enter the liver and are converted to 25-hydroxyvitamin D [25(OH)D3] (calcidiol).5 The calcidiol is the major circulating form of vitamin D and is used to determine vitamin D status. To become biologically active, it requires additional hydroxylation in the kidneys to form active 1, 25-hydroxyvitamin D [1, 25(OH) 2D] (calcitriol); however, 1,25(OH)2D is not used to determine vitamin D status because it circulates at 1000 times less concentration than 25(OH)D3 and it has a half life of 6 hours in ...
Objective - Data relating vitamin D status with indices of glucose homeostasis as manifested by A1c in the U.S. adult population are few.. Research Design and Methods - We examined the association between serum 25-OH vitamin D and A1c levels in 9773 adults (age ≥ 18 years old) participating in the 2003-2006 National Health and Nutrition Examination Survey. Multivariate linear regression analyzed the association after accounting for potential confounders.. Results - Serum 25-OH vitamin D levels were inversely associated with A1c levels in subjects age 35 to 74 years (p=0.0045) and those who did not report a history of diabetes mellitus (p=0.0282).. Conclusions - These findings support a mechanistic link between serum vitamin D concentrations, glucose homeostasis, and the evolution of diabetes in a large segment of the U.S. adult population. Screening people with elevated A1c levels for vitamin D insufficiency should be considered.. ...
Autoimmune conditions are more likely to cluster in regions farther from equator. This is likely because of inadequate vitamin D levels. Vitamin D deficiency is associated with improper immune function-a lack of CD8+ T cells that kill off viruses like EBV and a lack of T-regulatory cells that keep the immune system balanced.. In recent years, the role of vitamin D in the health of human body has been strongly emphasized by researchers and the medical community alike. Serum vitamin D levels can be directly correlated with human life expectancy. Dr. William Grant, Ph.D., a vitamin D expert, has proposed that raising the serum vitamin D level would prevent 30% of cancer deaths each year.. Vitamin D affects about 3,000-30,000 genes in our bodies, and many diseases have also been connected to vitamin D levels, including heart disease, depression, and autoimmune conditions.. Vitamin D is known for its role in balancing Th-1 (cell-mediated) and Th-2 (humoral) immune system responses by influencing ...
Free Online Library: Lupus nephritis: an approach to diagnosis and treatment in South Africa.(Report) by South African Medical Journal; Health, general Alfacalcidol Health aspects Angiotensin Angiotensins Calcifediol Chronic kidney failure Care and treatment Development and progression Diagnosis Corticosteroids Glucocorticoids Immunotherapy Research Mortality Nephritis Systemic lupus erythematosus Urinalysis Urine Analysis Vitamin D
If the health benefits of high vitamin D concentrations shown by data from observational studies are not reproduced in randomized trials … then the relation between vitamin D status and disorders are probably the result of confounding or physiological events involved in these disorders, stated lead author Professor Philippe Autier from the International Prevention Research Institute in Lyon, France.. They found that the benefits of high vitamin D concentrations from observational studies - including reduced risk of cardiovascular events (up to 58%), diabetes (up to 38%), and colorectal cancer (up to 34%) - were not confirmed in randomized trials. According to Autier, What this discrepancy suggests is that decreases in vitamin D levels are a marker of deteriorating health. Ageing and inflammatory processes involved in disease occurrence and clinical course reduce vitamin D concentrations, which would explain why vitamin D deficiency is reported in a wide range of disorders.. This systematic ...
Blood levels of 25-hydroxyvitamin D are used as the primary indicator of vitamin D adequacy. Within the study sample of U.S. adults, a large fraction of younger and older adults were below a suggested desirable serum vitamin D concentration of at least 75 nanomoles-per-liter (nmol/L).. The study supports the idea that correcting inadequate blood levels of vitamin D is more important than increasing dietary calcium intake beyond 566 mg a day among women and 626 mg a day among men for better bone mineral density. For example, a higher calcium intake beyond 566 mg a day may only be important among women whose vitamin D concentrations are low (less than 50 nmol/L), according to authors. Details of this study can be found in the publication Journal of Bone and Mineral Research. ...
A more recent meta-analysis, which included data from five observational studies, found that increasing serum vitamin D levels to 34 ng/ml could reduce colorectal cancer incidence rates by half. Increasing serum vitamin D levels even higher produced greater colorectal cancer preventive benefits. Lead researcher Edward Gorham, Ph.D. explained, "We project a two-thirds reduction in incidence with serum levels of 46 ng/ml, which corresponds to a daily intake of 2,000 IU of vitamin D3. This would be best achieved with a combination of diet, supplements and 10 to 15 minutes per day in the sun" (Source: Johns Hopkins Medicine ...
A more recent meta-analysis, which included data from five observational studies, found that increasing serum vitamin D levels to 34 ng/ml could reduce colorectal cancer incidence rates by half. Increasing serum vitamin D levels even higher produced greater colorectal cancer preventive benefits. Lead researcher Edward Gorham, Ph.D. explained, "We project a two-thirds reduction in incidence with serum levels of 46 ng/ml, which corresponds to a daily intake of 2,000 IU of vitamin D3. This would be best achieved with a combination of diet, supplements and 10 to 15 minutes per day in the sun" (Source: Johns Hopkins Medicine ...
Seasonal differences in 25-hydroxyvitamin D levels for the HPLC-APCI-MS, RIA and CLIA assays.The error bars indicate 95% confidence intervals.
In this retrospective study, vitamin D deficiency was examined with body mass index (BMI) and lipid levels in a sample of Hispanic American adolescents. The prevalence of vitamin D deficiency among 234 subjects aged 13 to 19 years was 27.8%. Vitamin D deficiency was significantly associated with a BMI of 85 kg/m2 or higher (odds ratio = 2.02, 95% confidence interval = 1.11-3.69, χ2 = 5.37, P = .021), and 55.6% of the sample were overweight or obese (BMI ≥ 85%). In the overweight or obese subjects, vitamin D deficiency was significantly associated with higher mean lipid levels compared with those with adequate vitamin D levels: total cholesterol = 165 ± 28 ...
A number of studies have examined vitamin D status in large populations. For example, comprehensive analyses of NHANES data have previously been conducted [14, 15, 19]. A few of the findings of NHANES differ, however, from observations described here for the WCMC, UIHC, and ARUP clinical datasets. For example, the NHANES studies indicated that 25(OH)D concentrations are, in general, higher in males than females [15, 19]. A second observation of the published NHANES data is that children tended to have higher 25(OH)D concentrations than adults [15]. While we observed a general pattern of more optimal 25(OH)D status in childhood in all datasets analyzed, an improvement in 25(OH)D status later in adulthood was observed at WCMC, UIHC, and ARUP, demonstrating that 25(OH)D status changes throughout life. For the WCMC dataset, we were able to demonstrate this pattern using both immunoassay and LC-MS/MS 25(OH)D results.. It is likely that consumption of vitamin D fortified foods, as well as UV exposure ...
The oral dosing with cholecalciferol needed to achieve and maintain optimal serum concentration 25-hydroxyvitamin D (25OHD) is still controversial.. This study reports on the efficacy of supplementation with oral vitamin D3 1000 U/day for 3 18 months on serum 25OHD levels in 87 ambulatory patients with postmenopausal osteoporosis (mean age 63.5 years). Serum 25OHD, parathyroid hormone (PTH), calcium (serum, urine), phosphate, alkaline phosphatase and creatinine were measured before and after 3 mo (54 pts), 6 mo (27 pts), 9 mo (15 pts), 12 mo (25 pts), 18 mo (5 pts) of oral vitamin D supplementation.. At baseline, using a cut-off point of sufficiency of 30 ng/ml, 10.34% of patients were deficient (mean=7.77 ng/ml), 82.76% were insufficient (mean=16.19 ng/ml) and 6.9% were sufficient (mean=35.86 ng/ml).. After 3 months of supplementation none of the patients was deficient, 64.81% were insufficient (mean=22.91 ng/ml) and 35.19% were sufficient (mean=36.79 ng/ml). The increment in serum 25OHD was ...
Severe obesity is associated with abnormal lipids and increased risk for cardiovascular disease. Obesity is a risk factor for vitamin D deficiency. We examined relationship between 25-hydroxy vitamin D (25(OH)D) concentrations and lipids in children with severe obesity. Medical records of 376 children were reviewed. Linear regression models and logistic regression were used to examine the relationship between 25(OH)D and lipids after adjustment for age, gender, season of blood draw, body mass index (BMI) z-score, and BMI % of 95th percentile. Two-hundred sixty-three out of 376 children (70%) had 25(OH)D concentrations < 30 ng/mL. Concentrations of 25(OH)D were positively correlated with those of high-density lipoprotein cholesterol (HDL-C) (r2 = 0.08, r = 0.22, β = 0.16, 95% CI = 0.05-0.27, p = 0.004). HDL-C was lower in children with 25(OH)D < 30 ng/mL (n = 263) compared to those with 25(OH)D ≥ 30 ng/mL (n = 113) (41.3 ± 10.2 vs. 46.4 ± 12 mg/dL, p < 0.0001). Children with 25(OH)D
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Background: Recently, epidemiologic and genetic studies suggest a vital and complex role of vitamin D on immune system function and regulation. Vitamin D insufficiency has been linked with susceptibility to infection and autoimmune diseases. The relationship between vitamin D deficiency and risk of infections in early life is still under investigations . Objective: To examine the effect of vitamin D supplementation in the first 6-months of life on the immunity and risk of infections during the first year in infants . Methods: A prospective controlled study included 99 full term infants divided into two groups: group I included 48 infants supplemented with daily 400 I.U vitamin D for 6-months and group II included 51 infants not supplemented with vitamin D. Investigations needed for diagnosis of respiratory, gastrointestinal tract, and urinary tract infections were addressed every visit until the infants first birth day. Two mls of maternal blood were withdrawn for 25-hydroxy vitamin D ...
Black Americans had lower levels of total 25-hydroxyvitamin D and vitamin D-binding protein than whites, but similar levels of bioavailable 25-hydroxyvitamin D, and higher bone density.
Goat polyclonal Vitamin D Binding protein antibody validated for WB, ELISA and tested in Human. Immunogen corresponding to synthetic peptide
The obesity epidemic in the US has continued for over two decades as the proportion of overweight and obese adults in the population continues to rise. ..
Vitamin D deficiency is the most common vitamin deficiency in the world. It has been linked to autoimmune disease, cancer, and more. Learn how to diagnose and treat vitamin D deficiency.
View messages from patients providing insights into their medical experiences with Vitamin D Deficiency - Symptoms. Share in the message dialogue to help others and address questions on symptoms, diagnosis, and treatments, from MedicineNets doctors.
A new study from Australia reports that low blood vitamin D concentrations during pregnancy seem to be a risk factor for the development of postpartum depression symptoms.
Context Lower serum 25-hydroxyvitamin D concentrations are associated with greater risks of many chronic diseases across large, prospective community-based studies. Substrate 25-hydroxyvitamin D must be converted to 1,25-dihydroxyvitamin D for full biological activity, and complex metabolic pathways suggest that interindividual variability in vitamin D metabolism may alter the clinical consequences of measured serum 25-hydroxyvitamin D.. Objective To investigate whether common variation within genes encoding the vitamin D-binding protein, megalin, cubilin, CYP27B1, CYP24A1, and the vitamin D receptor (VDR) modify associations of low 25-hydroxyvitamin D with major clinical outcomes.. Design, Setting, and Participants Examination of 141 single-nucleotide polymorphisms in a discovery cohort of 1514 white participants (who were recruited from 4 US regions) from the community-based Cardiovascular Health Study. Participants had serum 25-hydroxyvitamin D measurements in 1992-1993 and were followed up ...
Relationship between vitamin D-binding protein polymorphisms and blood vitamin D level in Korean patients with COPD Youngmok Park,1 Young Sam Kim,1 Young Ae Kang,1 Ju Hye Shin,1 Yeon Mok Oh,2 Joon Beom Seo,3 Ji Ye Jung,1 Sang Do Lee2 On behalf of the KOLD study 1Division of Pulmonology, Department of Internal Medicine, Severance Hospital, Institute of Chest Diseases, Yonsei University College of Medicine, 2Department of Pulmonary and Critical Care Medicine, Clinical Research Center for Chronic Obstructive Airway Diseases, 3Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea Background: In chronic obstructive pulmonary disease (COPD), the blood vitamin D3 level is generally low, and genetic polymorphisms of vitamin D-binding protein encoded by the GC gene are associated with COPD development. In this study, we examined the relationship between GC polymorphisms and plasma vitamin D3 level in Korean patients
Name of the Test: "Bioavailable" Vitamin D (1, 25 dihydroxy). Alias Names : Weakly bound Vitamin D 1,25 ; Albumin bound Vitamin D 1, 25 dihydroxy(1,25 di OH). Bioavailable Vitamin D determination is useful when:. - There is a discrepancy with total vitamin D ( 25 OH ) with calcium & PTH levels(i.e) Renal dialysis patients. - There is an increased level of Vitamin D binding protein as in pregnancy Clinical applications:. Vitamin D is produced in the skin. Exogenous Vitamin D is absorbed in the intestine and converted to 25 hydroxy vitamin D. 25 hydroxy(OH)vitamin D is converted into bioactive vitamin D (1, 25 dihydroxyl vitamin D) in the kidney .Hence, patients with chronic renal failures results in vitamin D deficiency. Over 85 % of circulating 1, 25 dihydroxy D is tightly bound to a specific vitamin D binding protein (DBP). A lesser amount is bound loosely with albumin. Less than 1% is the free form of Vitamin D 1, 25 dihydroxy. DBP levels are high during pregnancy and individuals with estrogen ...
1,25-DHCC, 1,25-dihydroxy-22-ovavitamin D(3), 1,25-dihydroxycholecalciferol, 1,25-dihydroxy-vitamin-D (1,25(OH)(2)D), 1,25-dihydroxyvitamin D3, 1,25-diOHC, 1,25(OH) 2D3, 1-alpha (OH) D3, 19-nor-1, 1-alpha-hydroxycholecalciferol, 1-alpha-hydroxyvitamin D2, 1-hydroxyvitamin D, 22-oxacalcitriol (OCT), 24,25(OH)(2)vitamin D(3), 25 hydroxyvitamin D (25(OH)D), 25-dihydroxyvitamin D2, 25-dihydroxyvitamin D2, 19-nor-1, 25-HCC, 25-hydroxycholecalciferol, 25-hydroxyvitamin D, 25-hydroxyvitamin D3, 25-OHCC, 25-OHD3, activated 7-dehydrocholesterol, activated ergosterol, alfacalcidol, calcifediol, calcipotriene, calcipotriol, calcitriol, cholecalciferol, colecalciferol, cod liver oil, dichysterol, dihydrotachysterol, dihydrotachysterol 2, doxercalciferol, ecocalcidiol, ED-21 (vitamin D analog), ED-71 (vitamin D analog), ergocalciferol, ergocalciferolum, falecalcitrol, hexafluoro-1,25dihydroxyvitamin D3, irradiated ergosterol, maxacalcitol, MC903, Ostelin , paracalcin, paricalcitol, tacalcitol, Vi-delta ...
If sun exposure is insufficient, how adequate are the current recommendations to prevent vitamin D deficiency in mothers and children? Although vitamin D supplementation is effective in preventing vitamin D deficiency, the optimal vitamin D requirement in women and children is still unknown.12 21 71 In the past, studies by Delvin et al,72 Mallet et al73 and Cockburn et al74 showed that vitamin D supplements below 2000 IU/day did not effectively prevent deficiency. In pregnant women treated with 1000 IU vitamin D/day, maternal serum 25(OH)D levels ranged from a mean of 9.5 nmol/l at baseline to 25.3 nmol/l after receiving 1000 IU vitamin D/day during the last trimester.73 The post-supplementation value is consistent with the definition of deficiency.21 In a more recent study,75 supplementation of pregnant women belonging to minority groups in the UK with 800-1600 IU of vitamin D during pregnancy increased serum 25(OH)D levels from a mean of 14.5 nmol/l at baseline to only 28 nmol/l at term. In ...
BACKGROUND: Respiratory syncytial virus (RSV) is the most important pathogen causing severe lower respiratory tract infection (LRTI) in infants. Epidemiologic and basic studies suggest that vitamin D may protect against RSV LRTI. OBJECTIVE: To determine the association between plasma vitamin D concentrations at birth and the subsequent risk of RSV LRTI. DESIGN: A prospective birth cohort study was performed in healthy term neonates. Concentrations of 25-hydroxyvitamin D (25-OHD) in cord blood plasma were related to RSV LRTI in the first year of life, defined as parent-reported LRTI symptoms in a daily log and simultaneous presence of RSV RNA in a nose-throat specimen. RESULTS: The study population included 156 neonates. Eighteen (12%) developed RSV LRTI. The mean plasma 25-OHD concentration was 82 nmol/L. Overall, 27% of neonates had 25-OHD concentrations < 50 nmol/L, 27% had 50-74 nmol/L and only 46% had 25-OHD 75 nmol/L. Cord blood 25-OHD concentrations were strongly associated with ...

Browse In Hypocalciuria, TRAP 5b, Calcifediol, Alanine aminotransferase, C1NP | EDM Case ReportsBrowse In Hypocalciuria, TRAP 5b, Calcifediol, Alanine aminotransferase, C1NP | EDM Case Reports

Hepatitis C-associated osteosclerosis (HCAO), a very rare disorder in which an extremely rapid bone turnover occurs and results in osteosclerosis, was acknowledged in 1990s as a new clinical entity with the unique bone disorder and definite link to chronic type C hepatitis, although the pathogenesis still remains unknown. Affected patients suffer from excruciating deep bone pains. We report the 19th case of HCAO with diagnosis confirmed by bone biopsy, and treated initially with a bisphosphonate, next with corticosteroids and finally with direct acting antivirals (DAA: sofosbuvir and ribavirin) for HCV infection. Risedronate, 17.5 mg/day for 38 days, did not improve the patients symptoms or extremely elevated levels of bone markers, which indicated hyper-bone-formation and coexisting hyper-bone-resorption in the patient. Next, intravenous methylprednisolone pulse therapy followed by high-dose oral administration of prednisolone evidently improved them. DAA therapy initiated after steroid ...
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Browse In Bone, TRAP 5b, Calcifediol, Bone pain, Alanine aminotransferase, C1NP | EDM Case ReportsBrowse In Bone, TRAP 5b, Calcifediol, Bone pain, Alanine aminotransferase, C1NP | EDM Case Reports

Hepatitis C-associated osteosclerosis (HCAO), a very rare disorder in which an extremely rapid bone turnover occurs and results in osteosclerosis, was acknowledged in 1990s as a new clinical entity with the unique bone disorder and definite link to chronic type C hepatitis, although the pathogenesis still remains unknown. Affected patients suffer from excruciating deep bone pains. We report the 19th case of HCAO with diagnosis confirmed by bone biopsy, and treated initially with a bisphosphonate, next with corticosteroids and finally with direct acting antivirals (DAA: sofosbuvir and ribavirin) for HCV infection. Risedronate, 17.5 mg/day for 38 days, did not improve the patients symptoms or extremely elevated levels of bone markers, which indicated hyper-bone-formation and coexisting hyper-bone-resorption in the patient. Next, intravenous methylprednisolone pulse therapy followed by high-dose oral administration of prednisolone evidently improved them. DAA therapy initiated after steroid ...
more infohttps://edm.bioscientifica.com/browse?pageSize=10&sort=datedescending&t_0=gland_2&t_1=investigation_383&t_2=investigation_71&t_3=signs-symptoms_94&t_4=investigation_19&t_5=investigation_67

Calcifediol: MedlinePlus Drug InformationCalcifediol: MedlinePlus Drug Information

Calcifediol: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Before taking calcifediol,. *tell your doctor and pharmacist if you are allergic to calcifediol, any other medications, or any ... Take calcifediol exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor. ... Calcifediol may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away: *joint pain ...
more infohttps://medlineplus.gov/druginfo/meds/a616041.html

Calcifediol - Substance Information - ECHACalcifediol - Substance Information - ECHA

Harmonised classification and labelling is a legally binding classification and labelling for a substance, agreed at European Community level. Harmonisation is based on the substances physical, toxicological and eco-toxicological hazard assessment. The Hazard classification and labelling section uses the signal word, pictogram(s) and hazard statements of the substance under the harmonised classification and labelling (CLH) as its primary source of information.. If the substance is covered by more than one CLH entry (e.g. disodium tetraborate EC no. 215-540-4, is covered by three harmonisations: 005-011-00-4; 005-011-01-1 and 005-011-02-9), CLH information cannot be displayed in the InfoCard as the difference between the CLH classifications requires manual interpretation or verification. If a substance is classified under multiple CLH entries, a link to the C&L Inventory is provided to allow users to view CLH information associated with the substance and no text is automatically ...
more infohttps://echa.europa.eu/substance-information/-/substanceinfo/100.039.067

Calcifediol - WikipediaCalcifediol - Wikipedia

At a typical daily intake of vitamin D3, its full conversion to calcifediol takes approximately 7 days. Calcifediol is then ... In medicine, a 25-hydroxy vitamin D (calcifediol) blood test is used to determine how much vitamin D is in the body. The blood ... Calcifediol (INN), also known as calcidiol, 25-hydroxycholecalciferol, or 25-hydroxyvitamin D (abbreviated 25(OH)D), is a ... Other countries often use nmol/L. Multiply ng/mL by 2.5 to convert to nmol/L. Increasing calcifediol levels are associated with ...
more infohttps://en.wikipedia.org/wiki/Calcifediol

Vitamin D (calcifediol)  and breastfeeding. Are they compatible?Vitamin D (calcifediol) and breastfeeding. Are they compatible?

Vitamin D (calcifediol) is also known as Calcifediol. Here it is a list of alternative known names:: *25-Hydroxycholecalciferol ... Calcifediol. Ficha técnica. 2015 Full text (in our servers) *Hollis BW, Wagner CL, Howard CR, Ebeling M, Shary JR, Smith PG, ... Calcifediol. Drug Summary. 2016 Full text (in our servers) *AEMPS. ...
more infohttp://www.e-lactancia.org/breastfeeding/vitamin-d-calcifediol/synonym/

calcifediol | Ligand page | IUPHAR/BPS Guide to PHARMACOLOGYcalcifediol | Ligand page | IUPHAR/BPS Guide to PHARMACOLOGY

calcifediol ligand page. Quantitative data and detailed annnotation of the targets of licensed and experimental drugs. ...
more infohttp://www.guidetopharmacology.org/GRAC/LigandDisplayForward?tab=refs&ligandId=6921

Safety, Efficacy, PK and PD of CTAP101 (Calcifediol) ER Capsules for SHPT in HD Patients VDI - Full Text View - ClinicalTrials...Safety, Efficacy, PK and PD of CTAP101 (Calcifediol) ER Capsules for SHPT in HD Patients VDI - Full Text View - ClinicalTrials...

Safety, Efficacy, PK and PD of CTAP101 (Calcifediol) ER Capsules for SHPT in HD Patients VDI. The safety and scientific ... Calcifediol. Vitamins. Micronutrients. Nutrients. Growth Substances. Physiological Effects of Drugs. Bone Density Conservation ... Maximum serum concentration of Calcifediol. *Increase mean serum total 25-hydroxyvitamin D [ Time Frame: 26 weeks ]. Increase ... CTAP101 Oral Capsules/Calcifediol, calcidiol, 25-hydroxyvitamin D3, 300mcg/weekly for 26 weeks ...
more infohttps://clinicaltrials.gov/ct2/show/NCT03602261?recrs=abc&

RAYALDEE (Calcifediol) dosage, indication, interactions, side effects | EMPRRAYALDEE (Calcifediol) dosage, indication, interactions, side effects | EMPR

Calcifediol) drug information & product resources from MPR including dosage information, educational materials, & patient ...
more infohttps://www.clinicalpainadvisor.com/rayaldee/drug/34629/

Calcifediol - DNA Damage Signalling and Repair InhibitorsCalcifediol - DNA Damage Signalling and Repair Inhibitors

Tag: Calcifediol. Transcriptional regulation is dependent upon the interactions between the RNA pol. Posted on April 27, 2017. ... Posted in Urokinase-type Plasminogen ActivatorTagged Calcifediol, NR4A3Leave a comment on Transcriptional regulation is ... Transcriptional regulation is dependent upon the interactions between the RNA pol II holoenzyme complex and Calcifediol ...
more infohttp://ranscombehouseglynde.com/tag/calcifediol/

Calcifediol, カルシフェジオール « New Drug ApprovalsCalcifediol, カルシフェジオール « New Drug Approvals

Weight: 400.64 Calcifediol (INN), also known as calcidiol,… ... Calcifediol カルシフェジオール Ro 8-8892 U 32070E (3b,5Z,7E)-9,10- ... Calcifediol (INN), also known as calcidiol, 25-hydroxycholecalciferol, or 25-hydroxyvitamin D (abbreviated 25(OH)D),[1] is a ... Calcifediol is then converted in the kidneys (by the enzyme 25(OH)D-1α-hydroxylase) into calcitriol (1,25-(OH)2D3), a ... In medicine, a 25-hydroxy vitamin D (calcifediol) blood test is used to determine how much vitamin D is in the body.[6] The ...
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Rayaldee ® (calcifediol) | Treatment for SHPT HCP
  WebsiteRayaldee ® (calcifediol) | Treatment for SHPT HCP Website

Rayaldee® (calcifediol) extended-release 30 mcg capsules is indicated for the treatment of secondary hyperparathyroidism in ... Use of extended-release calcifediol to treat secondary hyperparathyroidism in stages 3 and 4 chronic kidney disease. Am J ...
more infohttps://rayaldee.com/

Calcifediol | COX-2 contributes to the maintenance of flow-induced dilationCalcifediol | COX-2 contributes to the maintenance of flow-induced dilation

Posted in General , Tagged Calcifediol, Retn , Comments Off on Pancreatic cells are electrically excitable and respond to ... Tag Archives: Calcifediol. Pancreatic cells are electrically excitable and respond to raised glucose concentrations. Posted on ...
more infohttp://lifescienceexec.com/tag/calcifediol/

Calcifediol-loaded liposomes for local treatment of pulmonary bacterial infections.  | LJMU Research OnlineCalcifediol-loaded liposomes for local treatment of pulmonary bacterial infections. | LJMU Research Online

Calcifediol-loaded liposomes for local treatment of pulmonary bacterial infections..pdf Available under License Creative ... Calcifediol-loaded liposomes for local treatment of pulmonary bacterial infections Supplimentary..pdf - Supplemental Material ... The influence of vitamin D3 and its metabolites calcifediol (25(OH)D) and calcitriol on immune regulation and inflammation is ... Calcifediol-loaded liposomes for local treatment of pulmonary bacterial infections. European Journal of Pharmaceutics and ...
more infohttp://researchonline.ljmu.ac.uk/6620/

Vitamin D And Related Compounds (Oral Route, Parenteral Route) Description and Brand Names - Mayo ClinicVitamin D And Related Compounds (Oral Route, Parenteral Route) Description and Brand Names - Mayo Clinic

For calcifediol. * To treat diseases in which calcium is not used properly by the body or to treat bone disease in kidney ... Alfacalcidol, calcifediol, calcitriol, and dihydrotachysterol are forms of vitamin D used to treat hypocalcemia (not enough ... Alfacalcidol, calcifediol, calcitriol, dihydrotachysterol, and ergocalciferol do not usually cause any side effects when taken ... Only small amounts of alfacalcidol, calcifediol, calcitriol, or dihydrotachysterol pass into breast milk and these amounts have ...
more infohttps://www.mayoclinic.org/es-es/drugs-supplements/vitamin-d-and-related-compounds-oral-route-parenteral-route/description/drg-20069609?p=1

Vitamin D And Related Compounds (Oral Route, Parenteral Route) Proper Use - Mayo ClinicVitamin D And Related Compounds (Oral Route, Parenteral Route) Proper Use - Mayo Clinic

For calcifediol. * To treat diseases in which calcium is not used properly by the body or to treat bone disease in kidney ... While you are taking alfacalcidol, calcifediol, calcitriol, dihydrotachysterol, doxercalciferol or paricalcitol , your health ...
more infohttps://www.mayoclinic.org/es-es/drugs-supplements/vitamin-d-and-related-compounds-oral-route-parenteral-route/proper-use/drg-20069609

Agrochemicals,Agrochemicals Suppliers,Agrochemicals ManufacturersAgrochemicals,Agrochemicals Suppliers,Agrochemicals Manufacturers

Calcifediol. Cas No: 63283-36-3MSDS/COA Download Min.Order: 1 Gram. FOB Price: USD $ 850.0-850.0. / Gram ...
more infohttps://www.lookchem.com/Agrochemicals_cid6

Clindamycin phosphate- CAS Number 24729-96-2Clindamycin phosphate- CAS Number 24729-96-2

Calcifediol - Reference Spectrum. Unit. EPC0166001. Add to basket Calcipotriol (anhydrous) - Reference Spectrum. Unit. ...
more infohttps://www.lgcstandards.com/PL/en/Clindamycin-phosphate/p/EPC2269000

Kidney Week 2017Kidney Week 2017

Close more info about No iPTH Oversuppression With Extended-Release Calcifediol Loading... ...
more infohttps://www.renalandurologynews.com/home/conference-highlights/kidney-week-annual-meeting/kidney-week-2017/page/3/

Vitamin<...Vitamin<...

Calcifediol is a major circulating metabolite of vitamin D3 and acts as a competitive inhibitor with an apparent Ki of 3.9 μM. ... Calcifediol monohydrate(25-hydroxy Vitamin D3) is a prehormone that is produced in the liver by hydroxylation of vitamin D3 ( ... Calcifediol monohydrate Catalog No. A15032. Quick View .category-products .products-list .btn-quickcart { background: white; ...
more infohttps://www.adooq.com/vitamin.html

Ovarian endometriosis and vitamin D serum levels.  - PubMed - NCBIOvarian endometriosis and vitamin D serum levels. - PubMed - NCBI

Calcifediol. LinkOut - more resources. Full Text Sources. *Taylor & Francis. Medical. *Endometriosis - Genetic Alliance ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/27809683

25-Hydroxyvitamin D levels and the risk of stroke: a prospective study and meta-analysis.  - PubMed - NCBI25-Hydroxyvitamin D levels and the risk of stroke: a prospective study and meta-analysis. - PubMed - NCBI

Calcifediol. Grant support. *HL34594/HL/NHLBI NIH HHS/United States. *P01 CA087969/CA/NCI NIH HHS/United States ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/22442173

Nutrients (AA and Vitamins) Flashcards by Jennifer Mattar | BrainscapeNutrients (AA and Vitamins) Flashcards by Jennifer Mattar | Brainscape

D2, D3, calcifediol, calcitriol. Good for GI tract for phsophate absorption, kidneys,. Bone: osteoblasts receptors, helps for ...
more infohttps://www.brainscape.com/flashcards/nutrients-aa-and-vitamins-7058569/packs/11334578

Voriconazole Advanced Patient Information - Drugs.comVoriconazole Advanced Patient Information - Drugs.com

Detailed drug Information for voriconazole. Includes common brand names, drug descriptions, warnings, side effects and dosing information.
more infohttps://www.drugs.com/cons/voriconazole.html
  • Calcifediol (INN), also known as calcidiol, 25-hydroxycholecalciferol, or 25-hydroxyvitamin D (abbreviated 25(OH)D), is a prehormone that is produced in the liver by hydroxylation of vitamin D3 (cholecalciferol) by the enzyme cholecalciferol 25-hydroxylase which was isolated by Michael F. Holick. (wikipedia.org)
  • Rayaldee ® (calcifediol) extended-release 30 mcg capsules is indicated for the treatment of secondary hyperparathyroidism in adults with stage 3 or 4 chronic kidney disease and serum total 25-hydroxyvitamin D levels less than 30 ng/mL. (rayaldee.com)
  • Other countries often use nmol/L. Multiply ng/mL by 2.5 to convert to nmol/L. Increasing calcifediol levels are associated with increasing fractional absorption of calcium from the gut up to levels of 80 nmol/L (32 ng/mL).[citation needed] Urinary calcium excretion balances intestinal calcium absorption and does not increase with calcifediol levels up to ~400 nmol/L (160 ng/mL). (wikipedia.org)
  • A study by Cedric F. Garland and Frank C. Garland of the University of California, San Diego analyzed the blood from 25,000 volunteers from Washington County, Maryland, finding that those with the highest levels of calcifediol had a risk of colon cancer that was one-fifth of typical rates. (wikipedia.org)
  • Many other medications may also interact with calcifediol, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list. (medlineplus.gov)