An anti-inflammatory, synthetic glucocorticoid. It is used topically as an anti-inflammatory agent and in aerosol form for the treatment of ASTHMA.
The major circulating metabolite of VITAMIN D3. It is produced in the LIVER and is the best indicator of the body's vitamin D stores. It is effective in the treatment of RICKETS and OSTEOMALACIA, both in azotemic and non-azotemic patients. Calcifediol also has mineralizing properties.
Doubly unsaturated pregnane derivatives with two hydroxy groups substituted anywhere on the rings or side chains.
A nutritional condition produced by a deficiency of VITAMIN D in the diet, insufficient production of vitamin D in the skin, inadequate absorption of vitamin D from the diet, or abnormal conversion of vitamin D to its bioactive metabolites. It is manifested clinically as RICKETS in children and OSTEOMALACIA in adults. (From Cecil Textbook of Medicine, 19th ed, p1406)
A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).
The administration of drugs by the respiratory route. It includes insufflation into the respiratory tract.
Drugs that are used to treat asthma.
Hydrazine substituted by one methyl group.
A molecule that binds to another molecule, used especially to refer to a small molecule that binds specifically to a larger molecule, e.g., an antigen binding to an antibody, a hormone or neurotransmitter binding to a receptor, or a substrate or allosteric effector binding to an enzyme. Ligands are also molecules that donate or accept a pair of electrons to form a coordinate covalent bond with the central metal atom of a coordination complex. (From Dorland, 27th ed)
The study of the origin, nature, properties, and actions of drugs and their effects on living organisms.
The branch of pharmacology that deals directly with the effectiveness and safety of drugs in humans.
Small kinetoplastid mitochondrial RNA that plays a major role in RNA EDITING. These molecules form perfect hybrids with edited mRNA sequences and possess nucleotide sequences at their 5'-ends that are complementary to the sequences of the mRNA's immediately downstream of the pre-edited regions.
Services providing pharmaceutic and therapeutic drug information and consultation.
Financing of medical care provided to public assistance recipients.
Medical services for which no payment is received. Uncompensated care includes charity care and bad debts.
The state or quality of being kind, charitable, or beneficial. (from American Heritage Dictionary of the English Language, 4th ed). The ethical principle of BENEFICENCE requires producing net benefit over harm. (Bioethics Thesaurus)
Non-profit organizations concerned with various aspects of health, e.g., education, promotion, treatment, services, etc.
Instructional materials used in teaching.
A primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. It is used therapeutically in fluid and nutrient replacement.
Cellular release of material within membrane-limited vesicles by fusion of the vesicles with the CELL MEMBRANE.
The smallest divisions of the arteries located between the muscular arteries and the capillaries.
The physiological widening of BLOOD VESSELS by relaxing the underlying VASCULAR SMOOTH MUSCLE.
A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1).
A purely physical condition which exists within any material because of strain or deformation by external forces or by non-uniform thermal expansion; expressed quantitatively in units of force per unit area.
Artificial, single or multilaminar vesicles (made from lecithins or other lipids) that are used for the delivery of a variety of biological molecules or molecular complexes to cells, for example, drug delivery and gene transfer. They are also used to study membranes and membrane proteins.
The physiologically active form of vitamin D. It is formed primarily in the kidney by enzymatic hydroxylation of 25-hydroxycholecalciferol (CALCIFEDIOL). Its production is stimulated by low blood calcium levels and parathyroid hormone. Calcitriol increases intestinal absorption of calcium and phosphorus, and in concert with parathyroid hormone increases bone resorption.
A species of gram-negative, aerobic, rod-shaped bacteria commonly isolated from clinical specimens (wound, burn, and urinary tract infections). It is also found widely distributed in soil and water. P. aeruginosa is a major agent of nosocomial infection.
Colloids with a gaseous dispersing phase and either liquid (fog) or solid (smoke) dispersed phase; used in fumigation or in inhalation therapy; may contain propellant agents.
Characteristics or attributes of the outer boundaries of objects, including molecules.
Relocating a patient to a CLIMATE more suitable for health or for management of a health condition.
A condition in which functional endometrial tissue is present outside the UTERUS. It is often confined to the PELVIS involving the OVARY, the ligaments, cul-de-sac, and the uterovesical peritoneum.
Pathological processes of the OVARY.
A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.
A vitamin that includes both CHOLECALCIFEROLS and ERGOCALCIFEROLS, which have the common effect of preventing or curing RICKETS in animals. It can also be viewed as a hormone since it can be formed in SKIN by action of ULTRAVIOLET RAYS upon the precursors, 7-dehydrocholesterol and ERGOSTEROL, and acts on VITAMIN D RECEPTORS to regulate CALCIUM in opposition to PARATHYROID HORMONE.
A publication issued at stated, more or less regular, intervals.
"The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.

Calcium absorption and kinetics are similar in 7- and 8-year-old Mexican-American and Caucasian girls despite hormonal differences. (1/553)

To assess the possibility of ethnic differences in mineral metabolism in prepubertal children, we compared measures of calcium metabolism in 7- and 8-y-old Mexican-American (MA) and non-Hispanic Caucasian (CAU) girls (n = 38) living in southeastern Texas. We found similar fractional calcium absorption, urinary calcium excretion, calcium kinetic values and total-body bone mineral content in the MA and CAU girls. In contrast, parathyroid hormone (PTH) concentrations were greater in MA girls (4.01 +/- 0.47 vs. 1. 96 +/- 0.50 pmol/L, P = 0.005) than in CAU girls. Serum 25-hydroxyvitamin D concentrations were lower in MA girls (68.9 +/- 7.7 vs. 109.4 +/- 8.4 nmol/L, P = 0.001) than in CAU girls, but 1, 25-dihydroxyvitamin D concentrations did not differ between groups. Seasonal variability was seen for 25-hydroxyvitamin D concentrations in girls of both ethnic groups, but values in all of the girls were >30 nmol/L (12 ng/mL). We conclude the following: 1) greater PTH levels in MA girls than CAU girls are present without evidence of vitamin D deficiency; and 2) differences in 25-hydroxyvitamin D and PTH concentrations between MA and CAU girls do not have a large effect on calcium absorption, excretion or bone calcium kinetics. These data do not provide evidence for adjusting dietary recommendations for mineral or vitamin D intake by MA girls.  (+info)

Enzymatic properties of mouse 25-hydroxyvitamin D3 1 alpha-hydroxylase expressed in Escherichia coli. (2/553)

Renal 25-hydroxyvitamin D3 1 alpha-hydroxylase cDNA cloned from the kidneys of mice lacking the vitamin D receptor was expressed in Escherichia coli JM109. As expected, the bacterially-expressed enzyme catalyzes the 1 alpha-hydroxylation of 25-hydroxyvitamin D3 with a Michaelis constant, K(m), value of 2.7 microM. Unexpectedly, the enzyme also hydroxylates the 1 alpha-position of 24,25-dihydroxyvitamin D3 with a K(m) of 1.3 microM, and a fourfold higher Vmax/K(m) compared with the 25-hydroxyvitamin D3 hydroxylase activity, suggesting that 24,25-dihydroxyvitamin D3 is a better substrate than 25-hydroxyvitamin D3 for 1 alpha-hydroxylase. In addition, the enzyme showed 1 alpha-hydroxylase activity toward 24-oxo-25-hydroxyvitamin D3. However, it showed only slight activity towards 23,25-dihydroxyvitamin D3 and 24-oxo-23,25-dihydroxyvitamin D3, and no detectable activity towards vitamin D3 and 24,25,26,27-tetranor-23-hydroxyvitamin D3. These results suggest that the 25-hydroxyl group of vitamin D3 is essential for the 1 alpha-hydroxylase activity and the 24-hydroxyl group enhances the activity, but the 23-hydroxyl group greatly reduced the activity. Another remarkable finding is that living recombinant E. coli cells can convert the substrates into the 1 alpha-hydroxylated products, suggesting the presence of a redox partner of 1 alpha-hydroxylase in E. coli cells.  (+info)

Specific 1,25(OH)2D3-mediated regulation of transcellular calcium transport in Caco-2 cells. (3/553)

Calcium transport in the apical-to-basolateral (A-to-B) or B-to-A direction was examined in cells treated with 10 nM 1, 25-dihydroxyvitamin D3 [1,25(OH)2D3, calcitriol] for up to 72 h. Net A-to-B calcium transport was positive at all time points and increased from 0.14 +/- 0.06 to 0.50 +/- 0.01 nmol. well-1. min-1 after 72 h of calcitriol treatment. Neither phenol red transport nor transepithelial electrical resistance was altered by calcitriol treatment, suggesting that the increase in net A-to-B calcium transport was not due to paracellular movement. Neither 25-hydroxyvitamin D3 nor 24,25-dihydroxyvitamin D3 (100 nM, 48 h) alters basal or calcitriol-stimulated A-to-B calcium transport. Treatment with the calmodulin antagonist trifluoperazine (50 microM) reduced calcitriol-stimulated A-to-B Ca transport by 56%. The transcription inhibitor actinomycin D inhibited calcitriol-regulated A-to-B calcium transport as well as calbindin D9k and 24-hydroxylase mRNA accumulation. These data demonstrate that calcitriol-mediated A-to-B calcium transport in Caco-2 cells is a specific, transcellular process that requires transcriptional events normally mediated through the vitamin D receptor.  (+info)

Serum vitamin D levels and incident changes of radiographic hip osteoarthritis: a longitudinal study. Study of Osteoporotic Fractures Research Group. (4/553)

OBJECTIVE: The purpose of this study was to determine the relationship of serum levels of 25-vitamin D and 1,25-vitamin D to incident changes of radiographic hip osteoarthritis (OA) among elderly white women. METHODS: Baseline and followup hip radiographs of 237 subjects were obtained an average of 8 years apart. Hips were scored for individual radiographic features (IRF) and assigned a summary grade based on the number and type of IRF present. Serum 25- and 1,25-vitamin D levels from baseline samples were analyzed by radioimmunoassay. Logistic and linear regression were used to examine the association of 25- and 1,25-vitamin D levels with radiographic changes, adjusting for age, health status, physical activity, weight, vitamin D supplement use, and calcaneal bone mineral density. RESULTS: The risk of incident hip OA defined as the development of definite joint space narrowing was increased for subjects who were in the middle (odds ratio [OR] 3.21, 95% confidence interval [95% CI] 1.06, 9.68) and lowest (OR 3.34, 95% CI 1.13, 9.86) tertiles for 25-vitamin D compared with subjects in the highest tertile. Vitamin D levels were not associated with incident hip OA defined as the development of definite osteophytes or new disease according to the summary grade. No association between serum 1,25-vitamin D and changes in radiographic hip OA was found. CONCLUSION: Low serum levels of 25-vitamin D may be associated with incident changes of radiographic hip OA characterized by joint space narrowing.  (+info)

Autocrine control of vitamin D metabolism in synovial cells from arthritic patients. (5/553)

OBJECTIVE: This study was designed to investigate whether 1, 25-dihydroxyvitamin D3 (1,25-(OH)2D3), produced by activated synovial fluid macrophages, promotes its own catabolism by upregulating vitamin D-24-hydroxylase (24-OHase) in synovial fibroblasts through a vitamin D receptor (VDR) mediated mechanism. METHODS: Synovial macrophages and fibroblasts were derived from patients with rheumatoid arthritis. Expression of VDR and 24-OHase mRNAs was determined using in situ hybridisation. Vitamin D hydroxylase activity was determined by incubating cells with [3H]-25-(OH)D3, or [3H]-1,25-(OH)2D3, and metabolite synthesis quantified using high performance liquid chromatography. RESULTS: 1, 25-(OH)2D3 increased expression of mRNA for both VDR and 24-OHase in fibroblasts by approximately threefold over 24 hours. 1,25-(OH)2D3 increased fibroblast 24-OHase activity, yielding 24-hydroxylated, and more polar, metabolites. In co-culture, fibroblasts were able to catabolise macrophage derived 1,25-(OH)2D3. CONCLUSIONS: 1, 25-(OH)2D3 is produced by macrophages in vitro at biologically relevant concentrations and can increase its own catabolism by synovial fibroblasts; this effect is probably mediated via upregulation of both synovial fibroblast VDR and 24-OHase.  (+info)

Is low plasma 25-(OH)vitamin D a major risk factor for hyperparathyroidism and Looser's zones independent of calcitriol? (6/553)

BACKGROUND: Recent reports suggest that calcitriol might not be the sole active metabolite of vitamin D and that plasma concentrations of 25-(OH)vitamin D (25OHD) are often abnormally low in hemodialysis patients. We have therefore evaluated plasma 25OHD as a risk factor for parathyroid hormone (PTH) hypersecretion and radiological bone disease. We carried out a cross-sectional study during the month of September in an Algerian dialysis center of 113 patients who were not taking supplements of alphacalcidol or calcitriol. METHODS: Plasma 25OHD, calcitriol, PTH, calcium, phosphate, bicarbonate, and aluminum were measured, and x-rays of the hands and pelvis were obtained for evaluation of subperiosteal resorption and Looser's zones. RESULTS: The median plasma 25OHD was 47.5 nmol/liter (range 2.5 to 170.0). Univariate analysis showed that plasma PTH was correlated positively with months on maintenance dialysis and negatively with plasma 25OHD, calcitriol, calcium, bicarbonate and aluminum, but not with that of phosphate. plasma 25OHD was positively correlated with calcium and calcitriol. Using multiple regression analysis, only plasma 25OHD (negative) and the duration on maintenance dialysis (positive) were independently linked to plasma PTH. The prevalence of isolated subperiosteal resorption (ISR) was 34%, and that of the combination of resorption with Looser's zones (CRLZ) was 9%; thus, only 57% of the patients had a normal x-ray appearance. These groups were comparable with regards to age, gender, and duration on dialysis. When the biochemical measurements of the patients with CRLZ were compared with those from patients without radiological lesions, plasma 25OHD was the only parameter to show a statistically significant difference, being significantly lower in the CRLZ group (26 +/- 18 vs. 57 nmol/liter, ANOVA, P < 0.004). Plasma 25OHD was also significantly lower in the ISR group (44, P < 0.05) than in the normal x-ray group, and plasma Ca (P < 0.003) and bicarbonate (P < 0.02) were lower. Logistical analysis showed that the presence of resorption was independently linked only with plasma PTH. Looser's zones and subperiosteal resorption were not seen in patients with plasma 25OHD of more than 40 (Looser's zones) and more than 100 nmol/liter (subperiosteal resorption). The optimal range for intact PTH in hemodialysis patients with mild aluminum overload is 10 to 25 pmol/liter. We found that plasma PTH was inappropriately high only when plasma 25OHD was less than 100 nmol/liter. With a plasma 25OHD of between 100 and 170 nmol/liter, hypercalcemia was present with a plasma PTH of less than 10 pmol/liter in only one case. CONCLUSIONS: This cross sectional study shows that low plasma 25OHD is a major risk factor for hyperparathyroidism and Looser's zones. In dialysis patients, we suggest that the plasma levels of 25OHD are maintained around the upper limit of the reference range of sunny countries.  (+info)

Tissue engineering of a bioartificial renal tubule assist device: in vitro transport and metabolic characteristics. (7/553)

BACKGROUND: Current renal substitution therapy for acute or chronic renal failure with hemodialysis or hemofiltration is life sustaining, but continues to have unacceptably high morbidity and mortality rates. This therapy is not complete renal replacement therapy because it does not provide active transport nor metabolic and endocrinologic functions of the kidney, which are located predominantly in the tubular elements of the kidney. METHODS: To optimize renal substitution therapy, a bioartificial renal tubule assist device (RAD) was developed and tested in vitro for a variety of differentiated tubular functions. High-flux hollow-fiber hemofiltration cartridges with membrane surface areas of 97 cm2 or 0. 4 m2 were used as tubular scaffolds. Porcine renal proximal tubule cells were seeded into the intraluminal spaces of the hollow fibers, which were pretreated with a synthetic extracellular matrix protein. Attached cells were expanded in the cartridge as a bioreactor system to produce confluent monolayers containing up to 1.5 x 109 cells (3. 5 x 105 cells/cm2). Near confluency was achieved along the entire membrane surface, with recovery rates for perfused inulin exceeding 97 and 95% in the smaller and larger units, respectively, compared with less than 60% recovery in noncell units. RESULTS: A single-pass perfusion system was used to assess transport characteristics of the RADs. Vectorial fluid transport from intraluminal space to antiluminal space was demonstrated and was significantly increased with the addition of albumin to the antiluminal side and inhibited by the addition of ouabain, a specific inhibitor of Na+,K+-ATPase. Other transport activities were also observed in these devices and included active bicarbonate transport, which was decreased with acetazolamide, a carbonic anhydrase inhibitor, active glucose transport, which was suppressed with phlorizin, a specific inhibitor of the sodium-dependent glucose transporters, and para-aminohippurate (PAH) secretion, which was diminished with the anion transport inhibitor probenecid. A variety of differentiated metabolic functions was also demonstrated in the RAD. Intraluminal glutathione breakdown and its constituent amino acid uptake were suppressed with the irreversible inhibitor of gamma-glutamyl transpeptidase acivicin; ammonia production was present and incremented with declines in perfusion pH. Finally, endocrinological activity with conversion of 25-hydroxy(OH)-vitamin D3 to 1,25-(OH)2 vitD3 was demonstrated in the RAD. This conversion activity was up-regulated with parathyroid hormone and down-regulated with increasing inorganic phosphate levels, which are well-defined physiological regulators of this process in vivo. CONCLUSIONS: These results clearly demonstrate the successful tissue engineering of a bioartificial RAD that possesses critical differentiated transport, and improves metabolic and endocrinological functions of the kidney. This device, when placed in series with conventional hemofiltration therapy, may provide incremental renal replacement support and potentially may decrease the high morbidity and mortality rates observed in patients with renal failure.  (+info)

Effects of IGF-I on 1,25-dihydroxyvitamin D(3) synthesis by human placenta in culture. (8/553)

The aim of the present study was to assess the effects of insulin-like growth factor I (IGF-I) upon the synthesis of 1, 25-dihydroxyvitamin D(3) [1,25-(OH)(2)D(3)] by human placenta trophoblasts in culture. Cytotrophoblastic cells obtained from normal term human placentae were cultured in Dulbecco's modified Eagle's medium with HEPES and glucose (DMEM-HG) during 72 h and further incubated in serum-free DMEM-F12 in the presence of IGF-I prior to the addition of [(3)H]-25-(OH)D(3) used as a precursor. The results showed that 2 h preincubation time with IGF-I was required for maximal production of [(3)H]-1,25-(OH)(2)D(3). Cultures in the presence of increasing concentrations of IGF-I (0-6.5 nmol/l), added 2 h before incubation with the labelled substrate, resulted in a dose-dependent response increment of [(3)H]-1,25-(OH)(2)D(3) production with a maximal conversion rate at the dose of 2.6 nmol/l. Higher doses of IGF-I did not result in further stimulatory effects. Co-incubations in the presence of cycloheximide significantly (P < 0. 0001) inhibited the IGF-I-mediated effects upon [(3)H]-1, 25-(OH)(2)D(3) production. Identity of putative [(3)H]-1, 25-(OH)(2)D(3) produced by human placenta was confirmed by spectral and receptor binding analysis. These results demonstrate the ability of cultured human syncytiotrophoblast cells to convert 25-(OH)D(3) to 1,25-(OH)(2)D(3) and suggest a local protein-dependent regulatory effect of IGF-I upon this biotransformation.  (+info)

Calcifediol (also known as calcidiol, 25-hydroxycholecalciferol, or 25-hydroxyvitamin D (OH)D) is a prehormone produced in the liver by the enzyme cholecalciferol (vitamin D3). Calcifediol is then converted to calcitriol (1,25-(OH)2D3), which is the active form of vitamin D. The concentration of calcifediol in blood is considered the best indicator of vitamin D status. Researchers hypothesized that vitamin D supplementation would reduce the degree of chronic pain experienced by FMS patients with low levels of calcifediol and also might improve other symptoms. Low blood levels of calcifediol are especially common in patients with severe pain and fibromyalgia. But although the role of calcifediol in the perception of chronic pain is a widely discussed subject, we lack clear evidence of the role of vitamin D supplementation in fibromyalgia patients, says lead investigator Florian Wepner, MD, of the Department of Orthopaedic Pain Management, Spine Unit, Orthopaedic Hospital, Speising, Vienna, ...
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The IUPHAR/BPS Guide to Pharmacology. calcifediol ligand page. Quantitative data and detailed annnotation of the targets of licensed and experimental drugs.
RAYALDEE (Calcifediol) drug information & product resources from MPR including dosage information, educational materials, & patient assistance.
Milk, reduced fat, fluid, 2% milkfat, with added nonfat milk solids and vitamin A and vitamin D Nutrition - BellaOnline Nutrition Database - BellaOnline is committed to helping our visitors become healthy and happy. Our BellaOnline Nutrition Database will help you choose the healthiest foods for your chosen lifestyle.
Milk, reduced fat, fluid, 2% milkfat, with added vitamin A and vitamin D Nutrition - BellaOnline Nutrition Database - BellaOnline is committed to helping our visitors become healthy and happy. Our BellaOnline Nutrition Database will help you choose the healthiest foods for your chosen lifestyle.
Milk, reduced fat, fluid, 2% milkfat, with added vitamin A and vitamin D Nutrition - BellaOnline Nutrition Database - BellaOnline is committed to helping our visitors become healthy and happy. Our BellaOnline Nutrition Database will help you choose the healthiest foods for your chosen lifestyle.
Laminin-332 (Lm332) is a large heterotrimeric glycoprotein that has been identified Calcifediol as a scattering factor a regulator of malignancy invasion as well as a prominent basement membrane component of the skin. practical significance of 450-2 0 followed by data-dependent MS/MS for probably the most intense ions was performed in both Calcifediol positive and negative ion modes as previously reported (29). test with Microsoft Excel was used to compare the two groups. RESULTS and γas explained under Experimental Methods.??Total ion chromatograms were acquired by Calcifediol solitary mass scans (450-2 0 in positive (Fig. 4values of protonated molecules acquired by Fourier transform ion cyclotron resonance-MS and LAG3 fragment ions in MSspectra. Additional bisected 792 ([HexNAc-Hex-Hex-NAc-HexNAc-OH + H]+) and 938 ([HexNAc-Hex-HexNAc-(dHex-)HexNAc-OH + H]+) in MS/MS and MS/MS/MS spectra. The extracted ion chromatograms of representative bisected and was acquired in the experiment (data not ...
Pancreatic cells are electrically excitable and respond to raised glucose concentrations with bursts of Ca2+ action possibilities credited to the activation of voltage-dependent Ca2+ channels (VDCCs), which leads to the exocytosis of insulin granules. to glucose-evoked depolarization of the membrane … Continue reading →. ...
It it appears that vitamin D has much wider effects than previously recognized, according to researchers at the Buck Institute in northern California. Working
Vitamin D in the diet program or pores and skin synthesis is biologically inactive; enzymatic conversion (hydroxylation) while in the liver and kidney is necessary for activation. As vitamin D can be synthesized in suitable amounts by most mammals subjected to adequate daylight, It is far from A vital dietary element, and so not technically a vitamin.[three] Alternatively it may be regarded as a hormone, with activation from the vitamin D Professional-hormone causing the active kind, calcitriol, which then creates consequences through a nuclear receptor in numerous unique places.[3] Cholecalciferol is transformed within the liver to calcifediol (twenty five-hydroxycholecalciferol); ergocalciferol is transformed to 25-hydroxyergocalciferol ...
Higher serum calcifediol level is correlated with better β-cell function, lower insulin resistance, and decreased risk of CRC. Vitamin D may have suppressive effects on T2DM-associated complications and therefore represents a potential prophylactic treatment against β-cell dysfunction and cancer dev …
3D NUTRITIONQuality is of highest concern to 3D Nutrition which is why we publish the laboratory tests for each and every batch we manufacture on our website. We are also one of the few brands that do not use amino acid spiking to increase the nitrogen content of our whey products which leads to untrue protein readings during laboratory testing. ...
Ergocalciferol is given orally. Ergocalciferol is a form of prehormone which later converted into calcitriol and calcifediol. Calcifediol and calcitriol will increase the absorption of calcium and phosphate from intestine which increase the serum level of
Dose inhaled corticosteroids as the scale of the Spanish guide for asthma management (GEMA 4.0): Depends on the type of steroids:. Beclomethasone dipropionate (Low dose: 200-500 mcg/day, Half dose: 501-1000 mcg/day, High dose: 1001-2000 mcg/day), Beclomethasone extrafine (Low dose: 100-200 mcg/day, Half dose: 201-400 mcg/day, High dose: , 400 mcg/day), Budesonide (Low dose: 200-400 mcg/day, Half dose: 401-800 mcg/day, High dose: 801-1600 mcg/day), Ciclesonide (Low dose: 80-160 mcg/day, Half dose: 161-320 mcg/day, High dose: 321-1280 mcg/day), Fluticasone furoate (Half dose: 92 mcg/day, High dose: 184 mcg/day), Fluticasone propionate (Low dose: 100-250 mcg/day, Half dose: 251-500 mcg/day, High dose: 501-1000 mcg/day), Mometasone furoate (Low dose: 100-200 mcg/day, Half dose: 201-400 mcg/day, High dose: 401-800 mcg/day),. ...
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Vitamin D deficiency (hypovitaminosis D) is typically diagnosed by measuring the blood concentration of the 25-hydroxyvitamin D (Calcifediol, Calcidiol), which is a precursor to the active form of the 1,25-dihydroxy-vitamin D (Calcitriol) compound.. The blood concentration of 25-hydroxy-vitamin D reflects vitamin D produced in the skin as well as vitamin D acquired from the foods and has a relatively long circulating half-life of 15 days. It does not, however, reveal the amount of vitamin D stored in other body tissues and organs (muscles, liver, bones etc).. ...
Results: 70 subjects (86% male, 66% white, mean (SD) CD4 cell count 537.3 (191.5) per mm3) were randomized, of whom 26 (DRV/r) and 31 (Atripla) completed the 48 week study on the allocated treatment. The mean (SD) difference between baseline and week 48 25[OH]D was 5.0 (5.9) ng/mmol for DRV/r and 1.2 (6.0) for Atripla. After adjustment for baseline 25[OH]D and demographics, at week 48 DRV/r monotherapy was associated with a +3.5 (95% CI 0.5, 6.4) ng/mmol increase in 25[OH]D compared to Atripla (p=0.02). Subjects in the DRV/r arm experienced increases in BMD (mean between-arm difference (0.02 [0.003, 0.04] g/cm2 at the lumbar spine, p=0.03, and 0.03 [0.006, 0.06] g/cm2 at the neck of femur, p=0.02), and reductions in parathyroid hormone (PTH) (-20.4 [-38.8, -2.0] ng/l, p=0.03), bone-specific alkaline phosphatase (-7.1 [-9.7, -4.5]) IU/L, p< 0.0001) and serum type 1 pro-collagen (-16.9 [-26.5, -7.4] ug/L, p=0.0008), as compared with subjects on Atripla. No significant difference in RTD (urine ...
The 25-hydroxyvitamin D3 (25-OH-D3) is a nontoxic and low-affinity vitamin D receptor (VDR)-binding metabolic precursor of 1,25-dihydroxyvitamin D3 [1,25(OH)2D3]. We hypothesized that covalent attachment of a 25-OH-D3 analog to the hormone-binding pocket of VDR might convert the latter into transcriptionally active holo-form, making 25-OH-D3 biologically active. Furthermore, it might be possible to translate the nontoxic nature of 25-OH-D3 into its analog. We showed earlier that 25-hydroxyvitamin D3-3bromoacetate (25-OH-D3-3-BE) alkylated the hormonebinding pocket of VDR. In this communication we describe that 10 6 mol/L of 25-OH-D3-3-BE inhibited the growth of keratinocytes, LNCaP, and LAPC-4 androgen-sensitive and PC-3 and DU145 androgen-refractory prostate cancer cells, and PZ-HPV-7 immortalized normal prostate cells with similar or stronger efficacy as 1,25(OH)2D3. But its effect was strongest in LNCaP, PC-3, LAPC-4, and DU145 cells. Furthermore, 25-OH-D3-3-BE was toxic to these prostate cancer
Objective To synthesize mesoporous silica-core-shell magnetic nanoparticles (MNPs) encapsulated by liposomes (Lipo [[email protected] the targeting of breasts malignancy. 10, 11). Finally, using liposomes to encapsulate the coated nanoparticles is usually a well-established method that results in Calcifediol stable behavior in conjunction with a long circulation time. Liposomes can also contain a large number of MNP cores and can, therefore, deliver them undiluted, to the target site (12). In order to increase selectivity and recognition, antibodies targeting malignancy cells can be altered and secured onto the liposome encapsulated nanoparticles. One such ligand, receptor 2 (Her2), has been utilized for this technique. Although Her2/is usually expressed at low levels in normal adult tissues, it is upregulated in approximately 30% of breast cancers and 20% of ovarian cancers (13, 14). Trastuzumab (Her2/expression receptor antibody, Herceptin?, Genentech, Inc., South San Francisco, CA, USA) is usually a ...
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Low circulating concentrations of vitamin D metabolites have been associated with increased risk for several diseases and clinical conditions. Large observational studies and surveys have shown that obesity is independently associated with lower serum 25-hydroxyvitamin D (25(OH)D) concentration. Few …
Protein franskbrød nutrition facts and nutritional information. Find calories, carbs, and nutritional contents for Protein franskbrød and over 2,000,000 other foods at MyFitnessPal.com.
To elucidate the biosynthesis of 25-hydroxyvitamin D3-26,23-lactone, two known metabolites of 25-hydroxyvitamin D3--23,25-dihydroxyvitamin D3 and 25,26-dihydroxyvitamin D3--were incubated individually with kidney homogenate prepared from vitamin D-supplemented chickens, a preparation known to produce the lactone from 25-hydroxyvitamin D3. The 25-hydroxyvitamin D3-26,23-lactone produced in vitro was then separated, purified, identified, and quantitated by consecutive straight-phase and reverse-phase high-performance liquid chromatography. 23,25-Dihydroxyvitamin D3 is a far better substrate for production of 25-hydroxyvitamin D3-26,23-lactone than is 25,26-dihydroxyvitamin D3. Production of lactone is highly selective for the natural 23(S)-hydroxy-23,25-dihydroxyvitamin D3 while both epimers of 25,26-dihydroxyvitamin D3 resulted in small amounts of product comigrating with natural lactone. It appears that 23(S),25-dihydroxyvitamin D3, but not 25,26-dihydroxyvitamin D3, is a natural precursor in ...
The present study is one of the few studies investigating vitamin D status in the pediatric population in the southern region of the United States. In particular, this study is the first to address 25-hydroxyvitamin D levels over 4 seasons in a cohort of black and white adolescents living at southern US latitudes. Our data demonstrate that low vitamin D status is common among adolescents residing in the southeastern region and is related to various adiposity and lifestyle factors.. From NHANES III (1988-1994)2 to NHANES 2000-2004,2,24 the prevalence of vitamin D deficiency (25-hydroxyvitamin D levels of ≤50 nmol/L) in black and white adolescents increased from 28% to 48% and that of vitamin D insufficiency (25-hydroxyvitamin D levels of ≤75 nmol/L) increased from 66% to 81%. More importantly, ∼70% of the black adolescents in NHANES 2000-2004 had winter serum vitamin D deficiency, which might have important implications for known health disparities.24 The NHANES provided key information ...
In view of the high incidence of rickets in infants of women practising purdah (the use of veils) in northern Nigeria we conducted a study on plasma calcium, phosphate, and serum 25-hydroxyvitamin D (25 OHD) concentrations in pregnant Nigerian women and in cord blood obtained from the newborns. Plasma calcium, phosphate, and serum 25 OHD concentrations were lower in practising women and their newborns than those not practising purdah and their infants, respectively. The concentrations of 25 OHD in all Nigerian women were greater than those observed in caucasian women in the United Kingdom. These data emphasise the role of exposure to sunshine in regulating serum 25 OHD concentrations and the adverse effect of deliberate exclusion of sunshine and are consistent with previous data indicating hypovitaminosis D in purdah clad women and their newborns in Saudi Arabia. These data do not, however, provide an explanation for the pathogenesis of the high incidence of neonatal rickets and tetany in ...
BACKGROUND AND OBJECTIVES: The hydroxylation to 25-hydroxy vitamin D (25(OH)D) occurs in the liver and the impact of liver disease on vitamin D is unclear. This study evaluated the relationship between vitamin D concentrations and hepatic histopathology, seasonality and patient characteristics in well-characterized patients having undergone a liver biopsy. METHOD: 25(OH)D was measured post-hoc in pre-treatment serum from 331 North European patients with chronic HCV genotype 2 or 3 infection (NORDynamIC study). Liver biopsies were scored for fibrosis and inflammation according to the Ishak protocol, and graded for steatosis. Non-invasive markers of hepatic fibrosis as well as baseline viral and host characteristics, including genetic polymorphisms rs2228570, rs7975232, and rs10877012 were also evaluated. RESULTS: Mean 25(OH)D concentration was 59 ±23 nmol/L, with 41% having values <50 nmol/L and 6% were <30 nmol/L. 25(OH)D correlated with fibrosis (r = -0.10, p ≤0.05) in univariate but not in
A number of studies have suggested a link between low levels of vitamin D and higher incidence of chronic pain There is a well-established link between low vitamin D and pain due toosteomalacia. There is no clear biological mechanism of how low We searched Medline (PubMed) using various search terms for vitamin D might be causally related to other types of chronic pain, vitamin D (vitamin D; vitamin D2; vitamin D3; 1-alpha-hydroxyvi- though vitamin D is thought to be involved in regulating inflamma- tamin D3; 1-alpha hydroxycalciferol; 1,25-dihydroxyvitamin D3; tory cytokine synthesis , and might be implicated in some hydroxyvitamin D; alfacalcidol; calcidiol; calcitriol; calcifediol; Associations of pain with latitude and season of the year offer calciferol; ergocalciferol; cholecalciferol; and spelling variations circumstantial evidence that vitamin D may be involved. These thereof) and pain*. The last search was conducted on 8 Septem- associations have been suggested for such diverse ...
TY - JOUR. T1 - Serum vitamin D concentrations and unexplained elevation in ALT among US adults. AU - Liangpunsakul, Suthat. AU - Chalasani, Naga. PY - 2011/7. Y1 - 2011/7. N2 - Background: Low serum levels of vitamin D are associated with metabolic syndrome. Participants in NHANES III with unexplained elevation in ALT levels have high prevalence of metabolic syndrome. We hypothesized that the serum concentrations of vitamin D were inversely associated with unexplained elevation in ALT. Methods: A total of 6,826 fasting subjects underwent morning physical examination and met the inclusion and exclusion criteria. From these participants, we have constructed cases with unexplained elevation in ALT (n = 308) and compared their serum vitamin D concentrations to matched controls with normal ALT (N = 979). We examined the prevalence of unexplained elevation in ALT level across different quartiles of vitamin D levels. Results: Participants with unexplained elevation in ALT had significantly lower serum ...
Vitamin D is a fundamentally important hormone involved in calcium absorption, bone mineralization and parathyroid hormone production. Vitamin D deficiency may result in a myriad of diseases, such as osteomalacia, rickets and has more recently been identified as a risk factor for diabetes. Accurate determination of serum vitamin D levels is, therefore, paramount when assessing an individual for related pathologies against an appropriate reference range for interpretation. The purpose of this study was to assess vitamin D status between healthy Caucasian and healthy Asian populations of Peterborough, taking into account seasonal serum vitamin D variation. In addition, we evaluated whether a reference range for serum vitamin D of the local population should be race and/or seasonal specific. Using a Chromsystems high-pressure liquid chromatography vitamin D2/D3 methodology upon Agilent 1100 hardware, serum vitamin D status was assessed in 200 subjects of varying age, gender and ethnicity using ...
By Mark, Sean Gray-Donald, Katherine; Delvin, Edgard E; OLoughlin, Jennifer; Paradis, Gilles; Levy, Emile; Lambert, Marie BACKGROUND: Adequate vitamin D status is important for bone growth and mineralization and has been implicated in the regulation of autoimmunity, metabolic function, and cancer prevention. There are no reports of population-based studies on the vitamin D status of Canadian youth, a population with mandatory fortification of foods. METHODS: We measured plasma 25-hydroxyvitamin D [25(OH)D], the best indicator of vitamin D status, in a school-based cross- sectional sample of representative French Canadian youth (n = 1753) ages 9, 13, and 16 years living in Quebec (latitude: 45[degrees]- 48[degrees]N). Blood samples were collected from January to May 1999. We defined 25(OH)D deficiency as =27.5 nmol/L, hypovitaminosis as =37.5 nmol/L, and optimal as ,75.0 nmol/L. RESULTS: More than 93% of youth in each age and sex group had suboptimal 25(OH)D concentrations. The prevalence of ...
Smokers with low vitamin D concentrations had a higher risk of developing diabetes during their pregnancy than did nonsmokers with adequate vitamin D levels. Both smoking and having low vitamin D levels put women at a greater risk than either risk factor alone. The researchers concluded more investigation is needed to confirm their results and study the interactive effect of smoking and low vitamin D levels.A total of 20 ng/ml (nanograms/milliliter) to 50 ng/ml of vitamin D is considered an average blood level. If the level falls below 12 ng/ml, it is seen as deficient. Vitamin D deficiency could have been what Charles Dickens had in mind when he created Tiny Tim crippled. A deficiency of the vitamin causes rickets in children and osteomalacia in adults: bones can become brittle, thin, or misshapen.. Fortunately, both human skin and mushrooms make vitamin D when exposed to sunlight. So mothers can take in their vitamin D naturally from being outdoors for a few minutes a day without sunscreen, or ...
Product Human 25 Hydroxy Vitamin D ELISA kit From B-Gene - A sandwich ELISA for quantitative measurement of Human 25 Hydroxy Vitamin D in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUTION*1 vial 12. WASH SOLUTION (100 x)*1 vial 13. BALANCE SOLUTION*1 vial 14. INSTRUCTION*1
Free Online Library: Is bone tenderness, as measured by manual algometry, associated with vitamin D deficiency?(Report, Author abstract) by Journal of the Canadian Chiropractic Association; Health, general Alfacalcidol Health aspects Bone diseases Care and treatment Risk factors Calcifediol Pain Vitamin D Vitamin D deficiency Complications and side effects
TY - JOUR. T1 - Calcium absorption varies within the reference range for serum 25-hydroxyvitamin d. AU - Heaney, Robert P.. AU - Dowell, M. Susan. AU - Hale, Cecilia A.. AU - Bendich, Adrianne. PY - 2003/4/1. Y1 - 2003/4/1. N2 - Background: Calcium absorption is generally considered to be impaired under conditions of vitamin D deficiency, but the vitamin D status that fully normalizes absorption is not known for humans. Objective: To quantify calcium absorption at two levels of vitamin D repletion, using pharmacokinetic methods and commercially 1marketed calcium supplements. Design: Two experiments performed in the spring of the year, one year apart. In the first, in which participants were pretreated with 25-hydroxyvitamin D (25OHD), mean serum 25OHD concentration was 86.5 nmol/L; and in the other, with no pretreatment, mean serum concentration was 50.2 nmol/L. Participants received 500 mg oral calcium loads as a part of a standard low calcium breakfast. A low calcium lunch was provided at ...
title: Relationship between vitamin D-binding protein polymorphisms and blood vitamin D level in Korean patients with COPD., doi: 10.2147/COPD.S96985, category: Article
Osteopathic Medicine;Vitamin D-Binding Protein;Vitamin D Deficiency;Vitamin D;Hypercalcemia;S100 Calcium Binding Protein G;Bone Diseases;Calbindins;Calcifediol;Calcification, Physiologic;Gene Targeting;Hyperparathyroidism;Parathyroid Hormone;RNA ...
Osteopathic Medicine;Vitamin D-Binding Protein;Vitamin D Deficiency;Vitamin D;Hypercalcemia;S100 Calcium Binding Protein G;Bone Diseases;Calbindins;Calcifediol;Calcification, Physiologic;Gene Targeting;Hyperparathyroidism;Parathyroid Hormone;RNA ...
Investigation of serum 25 hydroxy vitamin D level in critically ill children and its relation with demographic and clinical risk factors, Bahare Yaghmaie, Fatemeh Sayarifard, Moham
Importance of 25-hydroxycholecalciferol (vitamin D) -Therapeutic target range for the body is at a high level. Check the level of 25-hydroxycholecalciferol (vitamin D) -Therapeutic target range and prevent health problems.
To date, 31 cases and 7 controls are enrolled. The mean ± SD case age is 7.2 ± 1.4 years; 55% are male. The mean control age is 6.4 ± 1.3 years; 57% are male. The mean 25-hydroxy vitamin D level for cases is 21.5 ± 7 ng/mL (n=23). This mean is at the cutpoint for vitamin D insufficiency [serum 25-hydroxy vitamin D level,20 ng/mL]. Ten cases (43%) are vitamin D insufficient. The mean 25-hydroxy vitamin D level for controls is 29 ± 3.3 ng/mL (n=4) … ...
This new report from VPGMarketResearch.com provides analysis of 25-Hydroxy Vitamin D2 and D3 testing, including clinical significance, current and emerging diagnostic ...
We explored the association between vitamin D status and total and specific cancers in the same populations. We found a statistically significant positive association between vitamin D status and the incidence of NMSC. Except for this, there were no statistically significant associations between vitamin D status and total cancer as well as specific cancers in the fully adjusted models. However, the inverse associations between vitamin D status and colorectal cancer and head and neck cancer were statistically and borderline significant, respectively, in the partly adjusted models.. Regarding other general population studies on vitamin D status and total cancer incidence, the results were inconclusive. Ordonez-Mena and colleagues found no statistically significant association between vitamin D status and the incidence of total cancer in a general German population cohort, except in subgroup analyses (23). Thus, there was a significantly increased overall cancer risk for low vitamin D status among ...
The study, presented at the American Society of Anesthesiologists 2007 Annual Meeting in San Francisco, found that one in four patients who suffer from chronic pain also have inadequate blood levels of vitamin D. As such, the researchers put forth that the vitamin D deficiency possibly contributed to the patients ongoing pain. Vitamin D deficiency - which can lead to osteopenia, osteoporosis, muscle weakness, fractures, common cancers, autoimmune diseases, infectious diseases and cardiovascular diseases - s been found to be lacking particularly in inhabitants of colder climates. A recent study, for example, indicated that the median adult intake of vitamin D in the US is only 230 IU per day, versus the researchers recommended 2000 IU per day. The latest study, undertaken at the Mayo Comprehensive Pain Rehabilitation Center in Rochester, Minnesota, involved 267 adults undergoing outpatient treatment for chronic pain. The researchers recorded their serum vitamin D levels, pain medication ...
The influence of vitamin D3 and its metabolites calcifediol (25(OH)D) and calcitriol on immune regulation and inflammation is well described, and raises the question of potential benefit against bacterial infections. In the current study, 25(OH)D was encapsulated in liposomes to enable aerosolisation, and tested for the ability to prevent pulmonary infection by Pseudomonas aeruginosa. Prepared 25(OH)D-loaded liposomes were nanosized and monodisperse, with a negative surface charge and a 25(OH)D entrapment efficiency of approximately 23%. Jet nebulisation of liposomes was seen to yield an aerosol suitable for tracheo-bronchial deposition. Interestingly, 25(OH)D in either liposomes or ethanolic solution had no effect on the release of the proinflammatory cytokine KC from Pseudomonas-infected murine epithelial cells (LA-4); treatment of infected, human bronchial 16-HBE cells with 25(OH)D liposomes however resulted in a significant reduction in bacterial survival. Together with the importance of ...
When prescribing vitamin D supplements, doctors ought to look at every individual patient as having different necessities and not rely on one-size-fits-all guidelines, according to a study by researchers at Rutgers and the University of California, San Francisco.. The study, published within the journal Metabolism, Clinical and Experimental, highlights the need to gain consensus via improved exams for vitamin D ranges that are currently available.. In line with the Institute of Medicine, individuals with lower than 20 nanograms of vitamin D per milliliter of blood are deficient. The Endocrine Society set a higher threshold of 30 nanograms. Neither guideline is extra definitive than the other at this time.. Vitamin Ds main function is to aid the body to absorb calcium. Deficiency can cause delayed skeletal development and rickets in children and should contribute to osteoporosis and increased risk of fracture in adults.. Vitamin D supplements work most excellent when taken with calcium for ...
Vitamin D, either in its D2 or D3 form, is essential for normal human development during intrauterine life, kidney function and bone health. Vitamin D deficiency has also been linked to cancer development and some autoimmune diseases. Given this huge impact of vitamin D on human health, it is important for daily clinical practice and clinical research to have reliable tools to judge on the vitamin D status. The major circulating form of vitamin D3 is 25-hydroxyvitamin D3 (25(OH)D), although is not the most active metabolite, the concentrations of total 25-hydroxy vitamin D3 in the serum are currently routinely used in clinical practice to assess vitamin D status ...
Causes of MS: It is not right to think vitamin D deficiency causes MS, but it seems a healthy level of vitamin D helps to prevent symptoms of MS in some people. There are several reports about this, some clinical trials are in progress. Corticosteroid medicine is often used temporarily to stop relapses of MS. Its effects on vitamin D are not relevant, the benefits of using it for a short time are better. ...Read more See 3 more doctor answers ...
AbstractBackground Poor vitamin D status (i.e. low serum 25-hydroxyvitamin D (25(OH)D)) has been associated with adverse clinical outcomes during pregnancy and childhood. However, the interpretation of serum 25(OH)D levels may be complicated by the presence of the C3-epimer of 25(OH)D. We aimed to quantify C3-epi-25(OH)D3 in pregnant women and fetuses, to explore the relationship of the C3-epimer between maternal and cord samples, and to establish whether infant C3-epimer abundance is explained by prenatal formation. Methods In a sub-study of a randomized trial of prenatal vitamin D3, 25(OH)D3 and C3-epi-25(OH)D3 were quantified by LC-MS/MS in 71 sets of mother-fetus-infant serum samples, including maternal delivery specimens, cord blood, and infant specimens acquired at 3-28 weeks of age. Results Without supplementation, median concentrations of C3-epi-25(OH)D3 were higher in infants (6.80 nmol/L) than mothers (0.45 nmol/L) and cord blood (0 nmol/L). However, there was substantial variation such that
An article published by Time Magazine discusses recent study that found insufficient vitamin D may lead to greater cognitive decline in older adults.
The aim of this study was to investigate the effect of consumption of vitamin D3 versus 25-hydroxyvitamin D3 biofortified eggs on winter serum 25(OH)D in adults using a 8-wk randomized controlled trial. This research will provide new data on the potential of vitamin D enriched eggs as a food-based strategy for prevention of vitamin D deficiency ...
Severe vitamin D deficiency causes the bones to soften and leads to bone disorders. In children, the most visible sign of vitamin D deficiency is bowed arms and legs. In adults, the most common symptom of vitamin D deficiency is generalized bone and muscle pain. ...
Recent evidence shows that low vitamin D status is related to higher risks for hypertension, dyslipidemia, diabetes, obesity, metabolic syndrome (MS), and cardiovascular (CVD) events. Some studies support the association between higher levels of vitamin D and a lower prevalence of cardiometabolic disease, however, this conclusion is not consistent in literature. PURPOSE: To investigate the associations of serum 25-hydroxyvitamin D (25(OH)D) concentration and clustering of risk factors for cardiometabolic disorders. METHODS: A total of 508 men and women (aged 19 to 70 years) from urban areas of Shanghai, China, were investigated. Demographic and anthropometric data were collected, and fasting blood samples were assessed for serum 25(OH)D, blood glucose and lipid concentrations. Participants were statistically grouped into tertiles according to their serum concentration level. Across the tertiles, linear regression analyses were used to evaluate associations between serum 25(OH)D concentration and
ANALYSIS OF PREVALENCE OF VITAMIN D DEFICIENCY IN ADULTS Author: Jana Nováková Supervisor: PharmDr. Eva Zimčíková, PhD. INTRODUCTION Estimated vitamin D deficiency occurs in up to 1/3 of the population. Vitamin D deficiency occurs in a number of diseases and in different countries of the world. AIMS The aim of the theoretical part of the diploma thesis was to get acquainted with vitamin D and its deficit in general. The objective of the practical part was to map vitamin D levels in adults, to assess prevalence of vitamin D deficiency, to determine if vitamin D levels fluctuate over the course of the year depending on age or gender and how they are related to individual illnesses. METHODS PubMed and Embase database search was performed to find evidence on vitamin D deficiency in adults. Only studies in humans, published in English in the period from 2000 to 2016 were included. Non-systematic review was provided, the quality of the studies was not evaluated. RESULTS Overall, 84 studies were ...
Ama : Ya da z nen bir vitamin olan D vitamini kemik ve kalsiyum metabolizmas n n d zenlenmesinde maj r bir rol oynar ve imm n ve kardiovask ler sistem zerinde etkilere sahiptir. D vitamini eksikli i genel populasyonun yan s ra kritik hastalarda da s k g r l r ve morbidite ve mortaliteyi artt rd bildirilmi tir. Bizim amac m z yo un bak m giri indeki D vitamini d zeyi ile mortalite ili kisini ara t rmakt ...
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A separate research study examines Vitamin D deficiency and Alzheimers Disease. Scientists speculate that lack of adequate Vitamin D could be one of the causal factors for Alzheimers. Another study (just published) finds an association between cognitive processing speed and administration of Vitamin D ...
Deficiency in vitamin D resulted in breast cancer tumors that grew faster and were more likely to metastasize, according to a recent study using mouse and cell culture models. The study also demonstrated a correlation between serum vitamin D levels and ID1.
Sufficient vitamin D status may be defined as the evolutionary established circulating 25-hydroxyvitamin D [25(OH)D] matching our Paleolithic genome. We studied serum 25(OH)D [defined as 25(OH)D2 + 25
Read about vitamin D deficiency treatment, causes, symptoms, signs, diagnosis, and daily limits chart. Depression, osteoporosis, allergies, and certain cancers have been tied to vitamin D deficiency.
Do You Have A Vitamin D Deficiency? Join 109 friendly people sharing 34 true stories in the I Have a Vitamin D Deficiency group. Find support forums, advice and chat with groups who share this life experience.
The test for a vitamin D deficiency is called the 25(OH)D test and measures the blood level of calcidiol. Test results in the U.S. tend to be in ng/ml.
Recent reports suggest that hypovitaminosis D in athletes is as common as in the general population. This study was devised to examine vitamin D status
ED07-03 Vitamin D insufficiency is now known to be the principal controllable cause of cancer of the colon, breast, and kidney, and is associated with higher incidence of cancer of the ovary, endometrium, several other malignancies, and all cancers as a group, except those mainly due to smoking, alcohol abuse, or long-term complications of viral infection. Insufficiency of vitamin D in childhood is associated with higher risk of prostate cancer. Consistent with this, low serum levels of the principal circulating vitamin D metabolite, 25-hydroxyvitamin D (25(OH)D), are associated with higher incidence and mortality rates from colon, breast, and ovarian cancer. There is a linear, inverse dose-response gradient between 25(OH)D and these cancers (serum levels in ng/ml may be multiplied by 2.5 to obtain nmol/L).. Dose-response relationships for cancers of the kidney, endometrium, and other solid tumors have been estimated from observational studies, a clinical trial, and natural experiments ...
Raising your serum 25-hydroxyvitamin D to 40ng/ml can help slash your risk of invasive cancers by 67 percent over those with low vitamin D levels.
Author: Kristen Bobik. Title: Help Patients Achieve Optimal Vitamin D Levels. Summary: Much research has been done on vitamin D levels and their impact on health; optimal levels have been correlated with a reduced risk of developing...
Here are seven signs and symptoms of vitamin D deficiency -- if you think you have any of these, you should get your vitamin D levels tested sooner.
Breast cancer patients with lower levels of vitamin D were far more likely to die and far more likely to have their cancer spread than women with normal levels, Canadian researchers reported on Thursday. In fact the women deficient in Vitamin D when they were diagnosed with breast cancer were 94 % more likely to have their cancer spread and were 73 % more likely to die than women with adequate vitamin D levels, and More than three-quarters of the women with breast cancer had a vitamin D deficiency the researchers said. The women with the lowest vitamin D levels had the highest risk of death from breast cancer, Dr ...
The reviewed research followed 1,658 adults who were free from dementia, cardiovascular disease and stroke for an average of 5.6 years (Littlejohns TJ, et al. 2014). Vitamin D levels (25-hydroxy vitamin D) were measured from blood samples. It was found that vitamin D deficiency is associated with a substantially increa
Calcifediol is implicated in the etiology of atherosclerosis, especially in non-Whites. The levels of the active form of ... In contrast, orally administered vitamin D produces rapid hepatic delivery of vitamin D and increases plasma calcifediol. It ... and free calcifediol enters the cell Intake of vitamin D raises the concentration of vitamin D metabolites which exceed DBP ... plasma calcifediol concentrations. Endogenously synthesized vitamin D3 travels mainly with vitamin D-binding protein (DBP), ...
It is converted in the liver to calcifediol (25-hydroxyvitamin D) which is then converted in the kidney to calcitriol (1,25- ... Hydroxylation in the kidneys of calcifediol to calcitriol by 1-alpha-hydroxylase is tightly regulated: it is stimulated by ... 25-Hydroxyvitamin D3 1-alpha-Hydroxylase, a kidney enzyme that converts calcifediol to calcitriol. Coulston AM, Boushey C, ... Hydroxylation in the endoplasmic reticulum of liver hepatocytes of cholecalciferol to calcifediol (25-hydroxycholecalciferol) ...
The only way to quantify adequate levels of vitamin D is with a serum 25(OH)D3 (calcifediol) test. In the United States, serum ...
... is, strictly, the 1-hydroxylation product of calcifediol (25-OH vitamin D3), derived from cholecalciferol (vitamin ... calcifediol) in the 1-alpha position. The activity of this enzyme is stimulated by PTH. This is an important control point in ... unlike its precursor calcifediol, whose halflife is measured in weeks. Calcitriol is inactivated by further hydroxylation to ...
Like vitamin D3 itself and calcifediol (25-hydroxyvitamin D3), it is inactive as a hormone both in vitro and in vivo. It was ...
... may refer to: 1-Hydroxycholecalciferol (Alfacalcidol) 25-Hydroxycholecalciferol (Calcifediol or ...
... it has been shown that oral administration of vitamin D does not linearly correlate to increased serum levels of calcifediol, ...
Extended Release Calcifediol was recently approved by the FDA as a treatment for secondary hyperparathyroidism (SHPT) in adults ...
... a song by Ludacris and Ty Dolla Sign Calcifediol (25-hydroxyvitamin D or 25(OH)D), an indicator of vitamin D status in the ...
... calcifediol MeSH D10.570.938.146.478.387 - dihydroxycholecalciferols MeSH D10.570.938.146.478.387.300 - calcitriol MeSH D10.570 ...
Calbon Calcarb 600 Calci-Chew Calci-Mix Calcibind Calciday-667 calcifediol (INN) Calcijex Calcimar Calcionate Calciparine ...
H05BA04 Elcatonin H05BX01 Cinacalcet H05BX02 Paricalcitol H05BX03 Doxercalciferol H05BX04 Etelcalcetide H05BX05 Calcifediol " ...
Maryland found that those with the highest levels of the vitamin D metabolite calcifediol had a risk of colon cancer that was ...
The molecular formula C27H44O2 may refer to: Alfacalcidol Calcifediol, or calcidiol Colestolone, or 5α-cholest-8(14)-en-3β-ol- ...
... calcifediol MeSH D04.808.247.222.159.478.387 - dihydroxycholecalciferols MeSH D04.808.247.222.159.478.387.300 - calcitriol MeSH ... calcifediol MeSH D04.808.247.808.146.478.387 - dihydroxycholecalciferols MeSH D04.808.247.808.146.478.387.300 - calcitriol MeSH ... calcifediol MeSH D04.808.812.768.196.478.387 - dihydroxycholecalciferols MeSH D04.808.812.768.196.478.387.300 - calcitriol MeSH ...
Intake of vitamin D raises plasma calcifediol concentrations which exceed the binding capacity of the DBP, and free calcifediol ... plasma calcifediol concentrations. Endogenously synthesized vitamin D3 travels mainly with vitamin D-binding protein (DBP), ... Calcifediol is implicated in the etiology of atherosclerosis, especially in non-Caucasians.[21][22] ... orally administered vitamin D produces rapid hepatic delivery of vitamin D and increases plasma calcifediol.[13] ...
In the liver, vitamin D was found to be converted to calcifediol. Calcifediol is then converted by the kidneys to calcitriol, ... Circulating calcifediol may then be converted into calcitriol, the biologically active form of vitamin D, in the kidneys.[169] ... Calcifediol is transported to the proximal tubules of the kidneys, where it is hydroxylated at the 1-α position (lower right of ... The activity of calcifediol and calcitriol can be reduced by hydroxylation at position 24 by vitamin D3 24-hydroxylase, forming ...
"Calcifediol (25-hydroxy-vitamin D) is implicated in the etiology of atherosclerosis, especially in non-Caucasians.[106][108][ ...
measuring the concentration of the calcifediol in the blood. UVB from sunlight is a large source of vitamin D. Oily fish such ... The serum concentration of calcifediol, also called 25-hydroxyvitamin D (abbreviated 25(OH)D), is typically used to determine ...
... , also known as vitamin D2 and calciferol, is a type of vitamin D found in food and used as a dietary supplement.[1] As a supplement it is used to prevent and treat vitamin D deficiency.[2] This includes vitamin D deficiency due to poor absorption by the intestines or liver disease.[3] It may also be used for low blood calcium due to hypoparathyroidism.[3] It is used by mouth or injection into a muscle.[2][3]. Excessive doses can result in increased urine production, high blood pressure, kidney stones, kidney failure, weakness, and constipation.[4] If high doses are taken for a long period of time, tissue calcification may occur.[3] It is recommended that people on high doses have their blood calcium levels regularly checked.[2] Normal doses are safe in pregnancy.[5] It works by increasing the amount of calcium absorbed by the intestines and kidneys.[4] Food in which it is found include some mushrooms.[6]. Ergocalciferol was first described in 1936.[7] It is on the World Health ...
Calcidiol/Calcifediol. *Calcitriol. *Cholecalciferol. *Others: 7α-Hydroxycholesterol. *11α-Hydroxyprogesterone. *11β- ...
Calcidiol/Calcifediol. *Calcitriol. *Cholecalciferol. *Others: 7α-Hydroxycholesterol. *11α-Hydroxyprogesterone. *11β- ...
Calcidiol/Calcifediol. *Calcitriol. *Cholecalciferol. *Others: 7α-Hydroxycholesterol. *11α-Hydroxyprogesterone. *11β- ...
Calcidiol/Calcifediol. *Calcitriol. *Cholecalciferol. *Others: 7α-Hydroxycholesterol. *11α-Hydroxyprogesterone. *11β- ...
Calcidiol/Calcifediol. *Calcitriol. *Cholecalciferol. *Others: 7α-Hydroxycholesterol. *11α-Hydroxyprogesterone. *11β- ...
血浆维生素D水平(來自維化命 D3 血液檢測(英语:Calcifediol#Blood test))可以反映紫外線
Calcifediol: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Before taking calcifediol,. *tell your doctor and pharmacist if you are allergic to calcifediol, any other medications, or any ... Take calcifediol exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor. ... Calcifediol may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away: *joint pain ...
Harmonised classification and labelling is a legally binding classification and labelling for a substance, agreed at European Community level. Harmonisation is based on the substances physical, toxicological and eco-toxicological hazard assessment. The Hazard classification and labelling section uses the signal word, pictogram(s) and hazard statements of the substance under the harmonised classification and labelling (CLH) as its primary source of information.. If the substance is covered by more than one CLH entry (e.g. disodium tetraborate EC no. 215-540-4, is covered by three harmonisations: 005-011-00-4; 005-011-01-1 and 005-011-02-9), CLH information cannot be displayed in the InfoCard as the difference between the CLH classifications requires manual interpretation or verification. If a substance is classified under multiple CLH entries, a link to the C&L Inventory is provided to allow users to view CLH information associated with the substance and no text is automatically ...
Calcifediol hydrate. P6YZ13C99Q. 63283-36-3. WRLFSJXJGJBFJQ-WPUCQFJDSA-N. Prescription Products. Name. Dosage. Strength. Route ... A high-fat, high-calorie meal may increase the AUC and Cmax of calcifediol by up to 3.5 and 5 fold, respectively. ... Calcifediol. Accession Number. DB00146 (NUTR00006, APRD00428) Type. Small Molecule. Groups. Approved, Nutraceutical. ... The risk or severity of adverse effects can be increased when Calcifediol is combined with 1alpha,24S-Dihydroxyvitamin D2. ...
Calcifediol lactone , C27H40O4 , CID 6438386 - structure, chemical names, physical and chemical properties, classification, ...
It also suppresses PTH secretion and mRNA (ED50=2 nM). Order Calcifediol from supplier Selleck for research use only. ... Calcifediol is a major circulating metabolite of vitamin D3 and acts as a competitive inhibitor with an apparent Ki of 3.9 μM. ... Calcifediol supplier , purchase Calcifediol , Calcifediol cost , Calcifediol manufacturer , order Calcifediol , Calcifediol ... Sellecks Calcifediol has been cited by 3 publications. * Dev Comp Immunol, 2020, 107:103644 PubMed: 32061641 (. click the link ...
Vitamin D (calcifediol) is also known as Calcifediol. Here it is a list of alternative known names:: *25-Hydroxycholecalciferol ... Calcifediol. Ficha técnica. 2015 Full text (in our servers) *Hollis BW, Wagner CL, Howard CR, Ebeling M, Shary JR, Smith PG, ... Calcifediol. Drug Summary. 2016 Full text (in our servers) *AEMPS. ...
Calcifediol Treatment and COVID-19-Related Outcomes. Posted: 22 Jan 2021 See all articles by Xavier Nogués. Xavier Nogués. ... Calcifediol Treatment and COVID-19-Related Outcomes. Available at SSRN: https://ssrn.com/abstract=3771318 or http://dx.doi.org/ ...
Calcifediol (Hidroferol®) in 16,000... Placebo in a presentation with an i... Arm/Group Description: Calcifediol (Hidroferol®) ... Calcifediol (Hidroferol®) in 16,000... Placebo in a presentation with an i... Arm/Group Description: Calcifediol (Hidroferol®) ... Calcifediol (Hidroferol®) in 16,000... Placebo in a presentation with an i... Arm/Group Description: Calcifediol (Hidroferol®) ... Calcifediol (Hidroferol®) in 16,000... Placebo in a presentation with an i... Arm/Group Description: Calcifediol (Hidroferol®) ...
Safety, Efficacy, PK and PD of CTAP101 (Calcifediol) ER Capsules for SHPT in HD Patients VDI. The safety and scientific ... Calcifediol. Vitamins. Micronutrients. Nutrients. Growth Substances. Physiological Effects of Drugs. Bone Density Conservation ... Maximum serum concentration of Calcifediol. *Increase mean serum total 25-hydroxyvitamin D [ Time Frame: 26 weeks ]. Increase ... CTAP101 Oral Capsules/Calcifediol, calcidiol, 25-hydroxyvitamin D3, 300mcg/weekly for 26 weeks ...
calcifediol ligand page. Quantitative data and detailed annnotation of the targets of licensed and experimental drugs. ...
Calcifediol) drug information & product resources from MPR including dosage information, educational materials, & patient ...
Hepatitis C-associated osteosclerosis (HCAO), a very rare disorder in which an extremely rapid bone turnover occurs and results in osteosclerosis, was acknowledged in 1990s as a new clinical entity with the unique bone disorder and definite link to chronic type C hepatitis, although the pathogenesis still remains unknown. Affected patients suffer from excruciating deep bone pains. We report the 19th case of HCAO with diagnosis confirmed by bone biopsy, and treated initially with a bisphosphonate, next with corticosteroids and finally with direct acting antivirals (DAA: sofosbuvir and ribavirin) for HCV infection. Risedronate, 17.5 mg/day for 38 days, did not improve the patients symptoms or extremely elevated levels of bone markers, which indicated hyper-bone-formation and coexisting hyper-bone-resorption in the patient. Next, intravenous methylprednisolone pulse therapy followed by high-dose oral administration of prednisolone evidently improved them. DAA therapy initiated after steroid ...
For calcifediol. * To treat diseases in which calcium is not used properly by the body or to treat bone disease in kidney ... Alfacalcidol, calcifediol, calcitriol, and dihydrotachysterol are forms of vitamin D used to treat hypocalcemia (not enough ... Alfacalcidol, calcifediol, calcitriol, dihydrotachysterol, and ergocalciferol do not usually cause any side effects when taken ... Only small amounts of alfacalcidol, calcifediol, calcitriol, or dihydrotachysterol pass into breast milk and these amounts have ...
For calcifediol. * To treat diseases in which calcium is not used properly by the body or to treat bone disease in kidney ... While you are taking alfacalcidol, calcifediol, calcitriol, dihydrotachysterol, doxercalciferol or paricalcitol , your health ...
Calcifediol (Calderol). Vitamin D regulates calcium homeostasis, promoting absorption of calcium by gut, resorption of calcium ...
Tag: Calcifediol. Transcriptional regulation is dependent upon the interactions between the RNA pol. Posted on April 27, 2017. ... Posted in Urokinase-type Plasminogen ActivatorTagged Calcifediol, NR4A3Leave a comment on Transcriptional regulation is ... Transcriptional regulation is dependent upon the interactions between the RNA pol II holoenzyme complex and Calcifediol ...
Weight: 400.64 Calcifediol (INN), also known as calcidiol,… ... Calcifediol カルシフェジオール Ro 8-8892 U 32070E (3b,5Z,7E)-9,10- ... Calcifediol (INN), also known as calcidiol, 25-hydroxycholecalciferol, or 25-hydroxyvitamin D (abbreviated 25(OH)D),[1] is a ... Calcifediol is then converted in the kidneys (by the enzyme 25(OH)D-1α-hydroxylase) into calcitriol (1,25-(OH)2D3), a ... In medicine, a 25-hydroxy vitamin D (calcifediol) blood test is used to determine how much vitamin D is in the body.[6] The ...
Rayaldee® (calcifediol) extended-release 30 mcg capsules is indicated for the treatment of secondary hyperparathyroidism in ... Use of extended-release calcifediol to treat secondary hyperparathyroidism in stages 3 and 4 chronic kidney disease. Am J ...
Posted in General , Tagged Calcifediol, Retn , Comments Off on Pancreatic cells are electrically excitable and respond to ... Tag Archives: Calcifediol. Pancreatic cells are electrically excitable and respond to raised glucose concentrations. Posted on ...
Calcifediol. Cas No: 63283-36-3MSDS/COA Download Min.Order: 1 Gram. FOB Price: USD $ 850.0-850.0. / Gram ...
Calcifediol-loaded liposomes for local treatment of pulmonary bacterial infections..pdf Available under License Creative ... Calcifediol-loaded liposomes for local treatment of pulmonary bacterial infections Supplimentary..pdf - Supplemental Material ... The influence of vitamin D3 and its metabolites calcifediol (25(OH)D) and calcitriol on immune regulation and inflammation is ... Calcifediol-loaded liposomes for local treatment of pulmonary bacterial infections. European Journal of Pharmaceutics and ...
... or calcifediol (CAL). The intention-to-treat population (PAR: n = 46; CAL: n = 47) was used for the analysis. The primary ... Paricalcitol Versus Calcifediol for Treating Hyperparathyroidism in Kidney Transplant Recipients. Cruzado, J.M. ; Lauzurica, R. ... Página principal , Artículos , Paricalcitol Versus Calcifediol for Treating Hyperparathyroidism in Kidney Transplant Recipients ... or calcifediol (CAL). The intention-to-treat population (PAR: n = 46; CAL: n = 47) was used for the analysis. The primary ...
Calcifediol - Reference Spectrum. Unit. EPC0166001. Add to basket Calcipotriol (anhydrous) - Reference Spectrum. Unit. ...
Calcifediol - Reference Spectrum. Unit. EPC0166001. Add to basket Calcipotriol (anhydrous) - Reference Spectrum. Unit. ...
Calcifediol. LinkOut - more resources. Full Text Sources. *Taylor & Francis. Medical. *Endometriosis - Genetic Alliance ...
Calcifediol. Grant support. *HL34594/HL/NHLBI NIH HHS/United States. *P01 CA087969/CA/NCI NIH HHS/United States ...
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Calcifediol. Vitamin D. Vitamins. Micronutrients. Growth Substances. Physiological Effects of Drugs. Bone Density Conservation ...
Calcifediol is implicated in the etiology of atherosclerosis, especially in non-Whites. The levels of the active form of ... In contrast, orally administered vitamin D produces rapid hepatic delivery of vitamin D and increases plasma calcifediol. It ... and free calcifediol enters the cell Intake of vitamin D raises the concentration of vitamin D metabolites which exceed DBP ... plasma calcifediol concentrations. Endogenously synthesized vitamin D3 travels mainly with vitamin D-binding protein (DBP), ...
  • E) Qualitative representations of zebrafish larvae, showing ISV to be unchanged or slightly reduced in response to 20 μM seocalcitol, maxacalcitol, calcitriol, calcifediol and tacalcitol treatment between 6 hpf and 2 dpf. (selleckchem.com)
  • F) Qualitative representation of intact ISV after 10 μM seocalcitol, maxacalcitol, calcitriol, calcifediol and tacalcitol treatment from 2-5 dpf. (selleckchem.com)
  • Alfacalcidol, calcifediol, calcitriol, and dihydrotachysterol are forms of vitamin D used to treat hypocalcemia (not enough calcium in the blood). (mayoclinic.org)
  • Alfacalcidol, calcifediol, and calcitriol are also used to treat certain types of bone disease that may occur with kidney disease in patients who are undergoing kidney dialysis. (mayoclinic.org)
  • Some strengths of ergocalciferol and all strengths of alfacalcidol, calcifediol, calcitriol, and dihydrotachysterol are available only with your doctor's prescription. (mayoclinic.org)
  • While you are taking alfacalcidol, calcifediol, calcitriol, dihydrotachysterol, doxercalciferol or paricalcitol , your health care professional may want you to follow a special diet or take a calcium supplement. (mayoclinic.org)
  • Calcifediol is then converted in the kidneys (by the enzyme 25(OH)D-1α-hydroxylase ) into calcitriol (1,25-(OH) 2 D 3 ), a secosteroid hormone that is the active form of vitamin D. It can also be converted into 24-hydroxycalcidiol in the kidneys via 24-hydroxylation. (newdrugapprovals.org)
  • It is converted in the liver to calcifediol (25-hydroxyvitamin D) which is then converted in the kidney to calcitriol (1,25-dihydroxyvitamin D). One of its actions is to increase the uptake of calcium by the intestines. (wikipedia.org)
  • The influence of vitamin D3 and its metabolites calcifediol (25(OH)D) and calcitriol on immune regulation and inflammation is well described, and raises the question of potential benefit against bacterial infections. (ljmu.ac.uk)
  • Educate practitioners about active vitamin D analogs (calcitriol, paricalcitol, doxercalciferol, calcifediol) and their contraindication for use with Crysvita. (ismp.org)
  • Create alerts to warn against the concomitant use of Crysvita and oral phosphates or active vitamin D analogs (calcitriol, paricalcitol, doxercalciferol, calcifediol) when claims are submitted for both drugs. (ismp.org)
  • 25-hydroxyvitamin D3 (calcifediol) is less effective than 1,25-dihydroxyvitamin D3 (calcitriol) in stimulating intestinal calcium transport, so that hypercalcemia is less of a problem with calcifediol. (brainscape.com)
  • Calcifediol is then converted to calcitriol (1,25-(OH)2D3), which is the active form of vitamin D. The concentration of calcifediol in blood is considered the best indicator of vitamin D status. (innovations-report.com)
  • In the liver, cholecalciferol is metabolized into calcifediol, which is further modified in the kidneys to become calcitriol. (wisegeek.com)
  • For example, conversion of calcifediol to calcitriol in the kidneys is regulated by parathyroid hormones secreted by the parathyroid glands. (wisegeek.com)
  • Calcifediol ( INN ), also known as calcidiol , 25-hydroxycholecalciferol , or 25-hydroxyvitamin D (abbreviated 25(OH)D ), [1] is a prehormone that is produced in the liver by hydroxylation of vitamin D 3 (cholecalciferol) by the enzyme cholecalciferol 25-hydroxylase which was isolated by Michael F. Holick . (newdrugapprovals.org)
  • In some countries, as in the case of Spain, 25-hydroxyvitamin D3, a metabolite of vitamin D, also called calcifediol or calcidiol, is also commercially available. (revistadeosteoporosisymetabolismomineral.com)
  • Calcifediol (also known as calcidiol, 25-hydroxycholecalciferol, or 25-hydroxyvitamin D (OH)D) is a prehormone produced in the liver by the enzyme cholecalciferol (vitamin D3). (innovations-report.com)
  • tell your doctor and pharmacist if you are allergic to calcifediol, any other medications, or any of the ingredients in calcifediol extended-release capsules. (medlineplus.gov)
  • A Multi-Center, Randomized, Two-Cohort Phase 2 Study to Evaluate the Safety, Efficacy, Pharmacokinetics and Pharmacodynamics of CTAP101 (calcifediol) Extended-Release Capsules to Treat Secondary Hyperparathyroidism in Subjects with Vitamin D Insufficiency and Chronic Kidney Disease Requiring Regular Hemodialysis. (clinicaltrials.gov)
  • Rayaldee ® (calcifediol) extended-release 30 mcg capsules is indicated for the treatment of secondary hyperparathyroidism in adults with stage 3 or 4 chronic kidney disease and serum total 25-hydroxyvitamin D levels less than 30 ng/mL. (rayaldee.com)
  • The present invention relates to calcifediol soft capsules, to their use in the treatment or prevention of diseases related to vitamin D deficiency, such as. (patents.com)
  • Calcifediol is a major circulating metabolite of vitamin D3 and acts as a competitive inhibitor with an apparent Ki of 3.9 μM. (selleckchem.com)
  • The study authors said in a statement, 'Our pilot study demonstrated that administration of a high dose of Calcifediol or 25-hydroxyvitamin D, the main metabolite of vitamin D endocrine system, significantly reduced the need for ICU treatment of patients requiring hospitalization due to proven Covid-19. (thehindubusinessline.com)
  • Our pilot study demonstrated that administration of a high dose of calcifediol or 25-hydroxyvitamin D, a main metabolite of vitamin D endocrine system, significantly reduced the need for ICU treatment of patients requiring hospitalisation due to proven COVID-19," said lead author of the report, Marta Entrenas Castillo of Reina Sofía University Hospital in Cordoba. (theolivepress.es)
  • [2] At a typical daily intake of vitamin D3, its full conversion to calcifediol takes approximately 7 days. (newdrugapprovals.org)
  • Calcifediol monohydrate(25-hydroxy Vitamin D3) is a prehormone that is produced in the liver by hydroxylation of vitamin D3 (cholecalciferol) by the enzyme cholecalciferol 25-hydroxylase. (adooq.com)
  • Pharmacokinetics of oral vitamin D3 and calcifediol. (uzh.ch)
  • The present invention relates to a co-crystal of calcifediol and vitamin D3, a preparation method therefor and use thereof. (sumobrain.com)
  • In the co-crystal, the molar ratio of calcifediol to vitamin D3 is 1: 1. (sumobrain.com)
  • 25-OH Vitamin D3 is also known as calcifediol, 25-Hydroxyvitamin D3, 25-Hydroxycholecalciferol. (genscript.com)
  • 10 mg/dl were randomized to paricalcitol (PAR) or calcifediol (CAL). (unizar.es)
  • The exact equivalence of this dose with vitamin D in terms of metabolic activity (how many IU of vitamin D activity is 1 µg of calcifediol) is not known with total precision, but the most widespread therapeutic regimen has been to administer once to the month or every fifteen days, compared to the 800-1,000 IU of cholecalciferol daily, as mentioned above. (revistadeosteoporosisymetabolismomineral.com)
  • The goal for the treatment group was to achieve serum calcifediol levels between 32 and 48ng/ml for 20 weeks via oral cholecalciferol supplements. (innovations-report.com)
  • 25-Hydroxyvitamin D 3 (calcifediol) is a prohormone produced via hydroxylation of vitamin D 3 (cholecalciferol) in the liver. (sigmaaldrich.com)
  • A total of 429 subjects, balanced between studies, with stage 3 or 4 CKD, SHPT and vitamin D insufficiency were randomized 2:1 to receive oral ER calcifediol (30 or 60 µg) or placebo once daily at bedtime for 26 weeks. (figshare.com)
  • iPTH lowering with ER calcifediol was independent of CKD stage and significantly greater than with placebo. (figshare.com)
  • Our bodies convert both compounds to 1,25-dihydroxyvitamin D. Levels of 25-hydroxyergocalciferol and calcifediol in blood describe a person's vitamin D status. (cdc.gov)
  • Blood tests for assessing a person's vitamin D status measure two forms: 25-hydroxyergocalciferol (25-hydroxyvitamin D2) and calcifediol (25-hydroxyvitamin D3). (cdc.gov)
  • ER calcifediol had inconsequential impact on serum calcium, phosphorus, FGF23 and adverse events. (figshare.com)
  • The concentration of iPTH decreased significantly after the administration of calcifediol, although on this occasion there were no differences between the two forms of treatment. (revistadeosteoporosisymetabolismomineral.com)
  • The proportion of subjects receiving ER calcifediol who achieved iPTH reductions of ≥30% increased progressively with treatment duration, reaching 22, 40 and 50% at 12, 26 and 52 weeks, respectively. (figshare.com)
  • Vitamin D oral supplementation and skin synthesis have a different effect on the transport form of vitamin D, plasma calcifediol concentrations. (wikipedia.org)
  • Oral ER calcifediol is safe and effective in treating SHPT and vitamin D insufficiency in CKD. (figshare.com)
  • Modified-release oral formulations of calcifediol indicated for the treatment of hyperparathyroidism are classified in this group. (whocc.no)
  • The present clinical studies evaluated extended-release (ER) calcifediol, a novel vitamin D prohormone repletion therapy designed to gradually correct low serum total 25-hydroxyvitamin D, improve SHPT control and minimize the induction of CYP24A1 and FGF23. (figshare.com)
  • Calcifediol is also sometimes used to treat osteomalacia (weakening and softening of the bones) due to liver disease. (medlineplus.gov)
  • Both are first metabolized by the liver, where they are converted to 25(OH)D (calcifediol). (endocrinologyadvisor.com)
  • According to some authors, severe vitamin D deficiency is when serum levels of 25-hydroxyvitamin D (25(OH)D or calcifediol) are below 10 ng/mL, moderate deficiency when they are between 10 and 20 ng/mL, insufficiency between 20 and 30 ng/mL and adequate values if they are above 30 ng/mL 1-3 . (revistadeosteoporosisymetabolismomineral.com)
  • In 2015, a cross-sectional analysis of the cardiovascular in rheumatology (CARMA) study found that patients with RA were at increased risk for 25(OH)D (calcifediol) deficiency compared with patients without chronic inflammatory rheumatic diseases (CIRD). (endocrinologyadvisor.com)
  • Calcifediol deficiency was detected in 40.5% of RA patients and 26.7% of non-CIRD patients. (endocrinologyadvisor.com)
  • Use of extended-release calcifediol to treat secondary hyperparathyroidism in stages 3 and 4 chronic kidney disease. (rayaldee.com)
  • Calcifediol-loaded liposomes for local treatment of pulmonary bacterial infections. (ljmu.ac.uk)
  • Monthly versus biweekley calcifediol in the treatment of osteoporotic patients. (revistadeosteoporosisymetabolismomineral.com)
  • Methods: We have studied 156 patients with osteoporosis (23 males and 133 females), aged 71,9±9,6 years who had received treatment with calcifediol for at least one year. (revistadeosteoporosisymetabolismomineral.com)
  • In a randomized controlled trial, 30 women with FMS with low serum calcifediol levels (below 32ng/ml) were randomized to a treatment or control group. (innovations-report.com)
  • The calcifediol levels were measured again 25 weeks after the start of the supplementation, at which time treatment was discontinued, and after a further 24 weeks without supplementation. (innovations-report.com)
  • Calcifediol is in a class of medications called vitamin D analogs. (medlineplus.gov)
  • The physiologically active form of vitamin D. It is formed primarily in the kidney by enzymatic hydroxylation of 25-hydroxycholecalciferol (CALCIFEDIOL). (nih.gov)
  • Conclusions: The monthly administration of 0.266 mg of calcifediol is adequate to achieve effective levels of vitamin D, and it is also safe enough to avoid reaching potentially harmful levels of it, so it would be preferable to the biweekly schedule in the usual clinical practice. (revistadeosteoporosisymetabolismomineral.com)
  • Your doctor may increase or adjust your dose depending on your body's response to calcifediol. (medlineplus.gov)
  • Ninety-two of them received 0.266 mg of calcifediol every fifteen days and the remaining 64 the same dose once a month. (revistadeosteoporosisymetabolismomineral.com)
  • Serum calcifediol levels were reevaluated after five and 13 weeks, and the dose was reviewed based on the results. (innovations-report.com)
  • Researchers hypothesized that vitamin D supplementation would reduce the degree of chronic pain experienced by FMS patients with low levels of calcifediol and also might improve other symptoms. (innovations-report.com)
  • But although the role of calcifediol in the perception of chronic pain is a widely discussed subject, we lack clear evidence of the role of vitamin D supplementation in fibromyalgia patients," says lead investigator Florian Wepner, MD, of the Department of Orthopaedic Pain Management, Spine Unit, Orthopaedic Hospital, Speising, Vienna, Austria. (innovations-report.com)
  • Transcriptional regulation is dependent upon the interactions between the RNA pol II holoenzyme complex and Calcifediol chromatin. (ranscombehouseglynde.com)
  • Calcifediol comes as an extended-release (long-acting) capsule to take by mouth. (medlineplus.gov)
  • Now larger trials of the drug are being carried out to confirm if calcifediol is able to reduce the severity of symptoms. (theolivepress.es)
  • Low blood levels of calcifediol are especially common in patients with severe pain and fibromyalgia. (innovations-report.com)
  • We therefore set out to determine whether raising the calcifediol levels in these patients would alleviate pain and cause a general improvement in concomitant disorders. (innovations-report.com)
  • In the study, median serum calcifediol levels were 20.4 ng/mL (range, 14.4-29.2 ng/mL) for patients with RA and 24.8 ng/mL (range, 18.4-32.6 ng/mL) for non-CIRD patients. (endocrinologyadvisor.com)
  • Many other medications may also interact with calcifediol, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list. (medlineplus.gov)
  • Most subjects (354 or 83%) completed dosing, and 298 (69%) entered a subsequent open-label extension study wherein ER calcifediol was administered without interruption for another 26 weeks. (figshare.com)
  • They say that calcifediol is safe, cheap and potentially very effective. (theolivepress.es)
  • In medicine, a 25-hydroxy vitamin D (calcifediol) blood test is used to determine how much vitamin D is in the body. (newdrugapprovals.org)