A calcium-binding protein that mediates calcium HOMEOSTASIS in KIDNEYS, BRAIN, and other tissues. It is found in well-defined populations of NEURONS and is involved in CALCIUM SIGNALING and NEURONAL PLASTICITY. It is regulated in some tissues by VITAMIN D.
Calcium-binding proteins that are found in DISTAL KIDNEY TUBULES, INTESTINES, BRAIN, and other tissues where they bind, buffer and transport cytoplasmic calcium. Calbindins possess a variable number of EF-HAND MOTIFS which contain calcium-binding sites. Some isoforms are regulated by VITAMIN D.
A calbindin protein found in many mammalian tissues, including the UTERUS, PLACENTA, BONE, PITUITARY GLAND, and KIDNEYS. In intestinal ENTEROCYTES it mediates intracellular calcium transport from apical to basolateral membranes via calcium binding at two EF-HAND MOTIFS. Expression is regulated in some tissues by VITAMIN D.
A calbindin protein that is differentially expressed in distinct populations of NEURONS throughout the vertebrate and invertebrate NERVOUS SYSTEM, and modulates intrinsic neuronal excitability and influences LONG-TERM POTENTIATION. It is also found in LUNG, TESTIS, OVARY, KIDNEY, and BREAST, and is expressed in many tumor types found in these tissues. It is often used as an immunohistochemical marker for MESOTHELIOMA.
Low molecular weight, calcium binding muscle proteins. Their physiological function is possibly related to the contractile process.
Agents, usually topical, that cause the contraction of tissues for the control of bleeding or secretions.
Proteins to which calcium ions are bound. They can act as transport proteins, regulator proteins, or activator proteins. They typically contain EF HAND MOTIFS.
The mucous lining of the LARYNX, consisting of various types of epithelial cells ranging from stratified squamous EPITHELIUM in the upper larynx to ciliated columnar epithelium in the rest of the larynx, mucous GOBLET CELLS, and glands containing both mucous and serous cells.
Secretagogins are EF HAND MOTIF-containing calcium-binding proteins that are involved in early neuronal migration and neurogenesis. They are also present in many adult organs and in brain and endocrine neoplasms.
Most generally any NEURONS which are not motor or sensory. Interneurons may also refer to neurons whose AXONS remain within a particular brain region in contrast to projection neurons, which have axons projecting to other brain regions.
Calcium-binding motifs composed of two helices (E and F) joined by a loop. Calcium is bound by the loop region. These motifs are found in many proteins that are regulated by calcium.
A bundle of NERVE FIBERS connecting each posterior horn of the spinal cord to the opposite side of the THALAMUS, carrying information about pain, temperature, and touch. It is one of two major routes by which afferent spinal NERVE FIBERS carrying sensations of somaesthesis are transmitted to the THALAMUS.
The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.
The physiologically active form of vitamin D. It is formed primarily in the kidney by enzymatic hydroxylation of 25-hydroxycholecalciferol (CALCIFEDIOL). Its production is stimulated by low blood calcium levels and parathyroid hormone. Calcitriol increases intestinal absorption of calcium and phosphorus, and in concert with parathyroid hormone increases bone resorption.
The output neurons of the cerebellar cortex.
Clusters of neurons in the somatic peripheral nervous system which contain the cell bodies of sensory nerve axons. Sensory ganglia may also have intrinsic interneurons and non-neuronal supporting cells.
The number of CELLS of a specific kind, usually measured per unit volume or area of sample.
Transference of fetal tissue between individuals of the same species or between individuals of different species.
Several groups of nuclei in the thalamus that serve as the major relay centers for sensory impulses in the brain.
An enzyme that catalyzes the formation of acetylcholine from acetyl-CoA and choline. EC 2.3.1.6.
The portion of renal tubule that begins from the enlarged segment of the ascending limb of the LOOP OF HENLE. It reenters the KIDNEY CORTEX and forms the convoluted segments of the distal tubule.
Common name for the species Gallus gallus, the domestic fowl, in the family Phasianidae, order GALLIFORMES. It is descended from the red jungle fowl of SOUTHEAST ASIA.
NEURONS in the inner nuclear layer of the RETINA that synapse with both the RETINAL PHOTORECEPTOR CELLS and the RETINAL BIPOLAR CELLS, as well as other horizontal cells. The horizontal cells modulate the sensory signal.
An order of BIRDS with the common name owls characterized by strongly hooked beaks, sharp talons, large heads, forward facing eyes, and facial disks. While considered nocturnal RAPTORS, some owls do hunt by day.
Proteins found mainly in icosahedral DNA and RNA viruses. They consist of proteins directly associated with the nucleic acid inside the NUCLEOCAPSID.
The practice of medicine as applied to special circumstances associated with military operations.
The main information-processing organs of the nervous system, consisting of the brain, spinal cord, and meninges.
Exclusive legal rights or privileges applied to inventions, plants, etc.
A class of large neuroglial (macroglial) cells in the central nervous system - the largest and most numerous neuroglial cells in the brain and spinal cord. Astrocytes (from "star" cells) are irregularly shaped with many long processes, including those with "end feet" which form the glial (limiting) membrane and directly and indirectly contribute to the BLOOD-BRAIN BARRIER. They regulate the extracellular ionic and chemical environment, and "reactive astrocytes" (along with MICROGLIA) respond to injury.
Diseases of any component of the brain (including the cerebral hemispheres, diencephalon, brain stem, and cerebellum) or the spinal cord.
A novel composition, device, or process, independently conceived de novo or derived from a pre-existing model.
A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)
A vitamin that includes both CHOLECALCIFEROLS and ERGOCALCIFEROLS, which have the common effect of preventing or curing RICKETS in animals. It can also be viewed as a hormone since it can be formed in SKIN by action of ULTRAVIOLET RAYS upon the precursors, 7-dehydrocholesterol and ERGOSTEROL, and acts on VITAMIN D RECEPTORS to regulate CALCIUM in opposition to PARATHYROID HORMONE.
A nutritional condition produced by a deficiency of VITAMIN D in the diet, insufficient production of vitamin D in the skin, inadequate absorption of vitamin D from the diet, or abnormal conversion of vitamin D to its bioactive metabolites. It is manifested clinically as RICKETS in children and OSTEOMALACIA in adults. (From Cecil Textbook of Medicine, 19th ed, p1406)
Proteins, usually found in the cytoplasm, that specifically bind calcitriol, migrate to the nucleus, and regulate transcription of specific segments of DNA with the participation of D receptor interacting proteins (called DRIP). Vitamin D is converted in the liver and kidney to calcitriol and ultimately acts through these receptors.
Organic substances that are required in small amounts for maintenance and growth, but which cannot be manufactured by the human body.
Retinol and derivatives of retinol that play an essential role in metabolic functioning of the retina, the growth of and differentiation of epithelial tissue, the growth of bone, reproduction, and the immune response. Dietary vitamin A is derived from a variety of CAROTENOIDS found in plants. It is enriched in the liver, egg yolks, and the fat component of dairy products.
Derivative of 7-dehydroxycholesterol formed by ULTRAVIOLET RAYS breaking of the C9-C10 bond. It differs from ERGOCALCIFEROL in having a single bond between C22 and C23 and lacking a methyl group at C24.
Organic chemistry methodology that mimics the modular nature of various biosynthetic processes. It uses highly reliable and selective reactions designed to "click" i.e., rapidly join small modular units together in high yield, without offensive byproducts. In combination with COMBINATORIAL CHEMISTRY TECHNIQUES, it is used for the synthesis of new compounds and combinatorial libraries.
A vascular anomaly due to proliferation of BLOOD VESSELS that forms a tumor-like mass. The common types involve CAPILLARIES and VEINS. It can occur anywhere in the body but is most frequently noticed in the SKIN and SUBCUTANEOUS TISSUE. (from Stedman, 27th ed, 2000)

Distribution of cholinergic contacts on Renshaw cells in the rat spinal cord: a light microscopic study. (1/134)

1. Cholinergic terminals in the rat spinal cord were revealed by immunohistochemical detection of the vesicular acetycholine transporter (VAChT). In order to determine the relationships of these terminals to Renshaw cells, we used dual immunolabelling with antibodies against gephyrin or calbindin D28k to provide immunohistochemical identification of Renshaw cells in lamina VII of the ventral horn. 2. A total of 50 Renshaw cells were analysed quantitatively using a computer-aided reconstruction system to provide accurate localization of contact sites and determination of somatic and dendritic surface area. Dendrites could be traced for up to 413 microm from the soma in calbindin D28k-identified Renshaw cells and up to 184 microm in gephyrin-identified cells. 3. A total of 3330 cholinergic terminals were observed on 50 Renshaw cells, with a range of 21-138 terminal appositions per cell (mean 66.6 +/- 25.56 contacts per cell). The vast majority (83.5 %) of the terminals were apposed to dendrites rather than the soma. The overall density of cholinergic contacts increased from a little above 1 per 100 microm2 on the soma and initial 25 microm of proximal dendrites to 4-5 per 100 microm2 on the surface of dendritic segments located 50-250 microm from the soma. Single presynaptic fibres frequently formed multiple contacts with the soma and/or dendrites of individual Renshaw cells. 4. VAChT-immunoreactive terminals apposed to Renshaw cells varied in size from 0.6 to 6.9 microm in diameter (mean 2.26 +/- 0.94; n = 986) and were on average smaller than the cholinergic C-terminals apposed to motoneurones, but larger than VAChT-immunoreactive terminals contacting other ventral horn interneurones. 5. The high density and relatively large size of many cholinergic terminals on Renshaw cells presumably correlates with the strong synaptic connection between motoneurones and Renshaw cells. The fact that the majority of contacts are distributed over the dendrites makes the motoneurone axon collateral input susceptible to inhibition by the prominent glycinergic inhibitory synapses located on the soma and proximal dendrites. The relative positions and structural features of the excitatory cholinergic and inhibitory glycinergic synapses may explain why Renshaw cells, although capable of firing at very high frequency following motor axon stimulation, appear to fire at relatively low rates during locomotor activity.  (+info)

Alteration in the expression level of calbindin D28k in the periodontal ligament of the rat molar during experimental tooth movement. (2/134)

The present immunohistochemical study was designed to investigate changes in the distribution and expression level of calbindin D28k in the periodontal ligament during experimental tooth movement in the rat molar to clarify the physiological role of this protein in the ligament. In normal animals, calbindin D28k-like immunoreactivity appeared sparsely in spindle-shaped cells in the alveolar half of the periodontal ligament. Electron microscopic observations showed that these immunoreactive cells were characterized by well-developed rough-surfaced endoplasmic reticulum and phagosomes--which often contained collagen fibers--suggesting that these cells could be categorized as periodontal fibroblasts. Twelve hours following the onset of the experimental tooth movement, cells positive for calbindin D28k increased in number in the periodontal ligament, especially in the alveolar half of the pressured side. Immunoelectron microscopy showed that the calbindin D28k-immunopositive cells had morphological features similar to those of fibroblasts in the normal ligament, and that these cells occasionally made contact with immunonegative macrophage-like cells. Immunopositive cells gradually decreased in number, and the distribution of the cells and intensity of the immunoreactivity returned to normal levels by 14 days following the induction of the experimental tooth movement. The present results suggest that calbindin D28k plays an important role in the homeostasis and cyto-protection of fibroblasts in the periodontal ligament at the initial phase of experimental tooth movement.  (+info)

NMR investigation and secondary structure of domains I and II of rat brain calbindin D28k (1-93). (3/134)

Calbindin D28k, a member of the troponin C superfamily of calcium-binding proteins, contains six putative EF hand domains but binds only four calcium-atoms: one at a binding site of very high affinity and three calcium-atoms at binding sites of lower affinity. The high-affinity site could be located within domain I while domains III, IV, and V bind calcium less tightly. The recombinant protein construct calb I-II (residues 1-93) comprising the first two EF hands affords a unique opportunity to study a pair of EF hands with one site binding calcium tightly and the second site empty. A series of heteronuclear 2D, 3D and 4D high-resolution NMR experiments were applied to calb I-II, and led to the complete assignment of the 1H, 13C and 15N resonances. The secondary structure of the protein was deduced from the size of the 3JHN-Halpha coupling constants, the chemical shift indices of 1Etaalpha, 13Calpha, 13C' and 13Cbeta nuclei and from an analysis of backbone NOEs observed in 3D and 4D NOESY spectra. Four major alpha-helices are identified: Ala13-Phe23, Gly33-Ala50, Leu54-Asp63, Val76-Leu90, while residues Ala2-Leu6 form a fifth, flexible helical segment. Two short beta-strands (Tyr30-Glu32, Lys72-Gly74) are found preceding helices B and D and are arranged in an anti-parallel interaction. Based on these data a structural model of calb I-II was constructed that shows that the construct adopts a tertiary structure related to other well-described calcium-binding proteins of the EF-hand family. Surprisingly, the protein forms a homodimer in solution, as was shown by its NMR characterization, size-exclusion chromatography and analytical ultra-centrifugation studies.  (+info)

Exacerbation of damage and altered NF-kappaB activation in mice lacking tumor necrosis factor receptors after traumatic brain injury. (4/134)

Tumor necrosis factor alpha (TNFalpha) is widely expressed in both neurons and glia and has been shown to be upregulated after traumatic brain injury (TBI). TNFalpha receptor activation results in activation of the transcription factor nuclear factor kappaB (NF-kappaB), which may serve an antiapoptotic role via the induction of target genes manganese superoxide dismutase (MnSOD) and/or calbindin. In the present study, we used a controlled cortical impact model of TBI with pertinent lines of transgenic mice to combine both morphological characterization and molecular analysis to elucidate the role of TNFalpha after TBI. Measurements of both the lesion volume and the blood-brain barrier breach indicated exacerbations in mice rendered genetically deficient in both the p55 and p75 TNFalpha receptors (TNFR-KO) compared with wild-type animals. Additionally, animals genetically altered to overexpress MnSOD showed a significant decrease in lesion volume compared with that of control littermates, whereas no alterations were observed in mice lacking the calcium-binding protein calbindin D28k. Analysis of NF-kappaB activation and relative levels of MnSOD revealed delayed responses in the injured cortex of TNFR-KO animals compared with wild-type animals, implying that endogenous TNFalpha may be neuroprotective after TBI.  (+info)

Effect of chronic metabolic acidosis on calbindin expression along the rat distal tubule. (5/134)

Calbindin D28k has been reported to be involved in the transcellular calcium transport along the rat distal tubule. It has also been shown that chronic metabolic acidosis (CMA) induces significant hypercalciuria. The present study investigated whether CMA affects the mRNA and the protein expression of calbindin D28k along isolated distal tubule (DT) of rats. The animals were made acidotic by adding 0.28 mol/L NH4Cl to the drinking water for 7 d. This maneuver was associated with an increase in plasma ionized calcium. Inulin clearance experiments demonstrated that metabolic acidosis did not affect GFR, but it significantly increased both total and fractional urinary calcium excretion. To define the role of calbindin D28k, total RNA was extracted from DT, identified, and microdissected from collagenase-treated kidneys. cDNA was synthesized from RNA using reverse transcriptase and oligo(dT)(12-18) primers. Calbindin D28k mRNA abundance was semiquantified by a competitive reverse transcription-PCR, using an internal standard of cDNA that differed from the wild-type calbindin D28k by a deletion of 86 bp. The reverse transcription-PCR was performed starting from the same amount of total RNA. For each set of experiments, control and acidotic rats were studied in parallel. The identity of the DT was further verified by the presence of the thiazide-sensitive NaCl cotransporter (rTSC1) mRNA. Calbindin D28k mRNA abundance was 0.89 +/- 0.21 amol/ng total RNA in DT of CMA rats (n = 5) compared with 0.30 +/- 0.12 amol/ng total RNA of control rats (n = 5) (P < 0.05). Using specific rabbit polyclonal anti-calbindin D28k antibody, Western blotting was performed starting from thin slices of outer cortex. Densitometric analysis revealed that in acidotic rats (n = 7) there was a 17 +/- 5% (P < 0.05) increase in calbindin D28k protein abundance compared with controls (n = 7). These results indicate that in the rat, ammonium chloride loading induces an increase in filtered ionized calcium load that is associated with a significant upregulation of calbindin D28k both at the mRNA and protein level. These last effects will help to reduce the concomitant hypercalciuria, thus mitigating the consequence of CMA on calcium metabolism.  (+info)

Calbindin D28k-like immunoreactivity during the formation of the enamel-free area in the rat molar teeth. (6/134)

Previous studies have demonstrated the presence of calbindin D28k in the ameloblasts derived from the inner enamel epithelium. The occlusal surfaces of the rodent molars partly lack the enamel covering, which is referred to as enamel-free area (EFA). In the present study, we compared the immunohistochemical localization of calbindin D28k-like immunoreactivity (CB-LI) in the cells at the EFA (EFA cells) and ameloblasts of the rat molar teeth at the light microscopic level. CB-LI was strong in the ameloblasts of the presecretory through the protective stages, while it was faint at the late secretory to transitional stages. However, some mature ameloblasts lacked the immunoreactivity. On the other hand, the majority of EFA cells showed distinct polarization and elongation that were absent in few cells at the early stage of EFA formation. At all stages, the EFA cells adjacent to the ameloblasts showed CB-LI, however, some cells adjacent to the mature ameloblasts lacked the reaction. Intensive CB-LI was demonstrated in EFA cells at the reduced enamel epithelium. These immunohistochemical findings suggest EFA cells have cytochemical properties similar to those of ameloblasts.  (+info)

Calbindin-D28k is expressed in osteoblastic cells and suppresses their apoptosis by inhibiting caspase-3 activity. (7/134)

The rate of osteoblast apoptosis is a critical determinant of the rate of bone formation. Because the calcium-binding protein calbindin-D(28k) has anti-apoptotic properties in neuronal cells and lymphocytes, we searched for the presence of this protein in osteoblastic cells and investigated whether it can modify their response to proapoptotic signals. Calbindin-D(28K) was expressed at low levels in several osteoblastic cell lines and at high levels in primary cultures of murine osteoblastic cells. Transient transfection of rat calbindin-D(28k) cDNA blocked tumor necrosis factor alpha (TNFalpha)-induced apoptosis in osteoblastic MC3T3-E1 cells, as determined by cell viability and nuclear morphology of cells cotransfected with the green fluorescent protein targeted to the nucleus, whereas transfection of the empty vector had no effect. Calbindin-D(28k) levels in several stably transfected MC3T3-E1 lines were directly related to protection from TNFalpha-induced apoptosis. Purified rat calbindin-D(28k) markedly reduced the activity of caspase-3, a critical molecule for the degradation phase of apoptosis, in a cell-free assay. In addition, cell extracts from MC3T3-E1 cells expressing high levels of calbindin-D(28k) decreased caspase-3 activity, compared with extracts from vector-transfected cells. This effect was apparently unrelated to the calcium binding properties of calbindin, as chelation of calcium by EGTA or addition of other calcium-binding proteins such as calbindin-D(9k), S100, calmodulin, and osteocalcin, did not affect caspase-3 activity. Last, calbindin-D(28k) interacts with the active form of caspase-3 as demonstrated by a GST pull-down assay. These results demonstrate that calbindin-D(28k) is a biosynthetic product of osteoblasts with a role in the regulation of apoptosis. They also reveal that the antiapoptotic properties of calbindin-D(28k) may result not only from calcium buffering but also from the ability of the protein to interact with and to inhibit caspase-3 activity, a property that is independent of its calcium binding capability.  (+info)

Calbindin D28k-immunoreactive afferent nerve endings in the laryngeal mucosa. (8/134)

The distribution of the calbindin D28k in the laryngeal sensory structures was studied by immunohistochemistry, immunoelectronmicroscopy, and double immunofluorescence with calretinin-immunoreactivity. Moreover, origin of the nerve endings were observed using retrograde tracer, fast blue. Immunoreactivity for calbindin D28k was found in the various types of nerve endings in the larynx, namely, laminar nerve endings, nerve endings associated with the taste buds, intraepithelial nerve endings, and endocrine cells. The laminar endings with calbindin D28k-immunoreactivity were observed in the subepithelial connective tissue. In some endings, terminals were expanded. The laminar endings were also observed in the perichondrium of the epiglottic cartilage. In the epiglottic and arytenoid epithelia, thick nerve fibers with calbindin D28k-immunoreactivity ascending to taste buds and intragemmal nerve fibers were also observed. Within the epithelial layer, intraepithelial free nerve endings with calbindin D28k-immunoreactivity were observed. Furthermore, diffuse endocrine cells were observed within the laryngeal epithelium. By immunoelectron microscopy, immunoreaction products in the endings mentioned above were localized in the cytoplasm of the axon terminals and nerve fibers which contained with numerous mitochondria. Out of the 100 laminar endings, 18 endings were immunopositive for both calbindin D28k and calretinin, 33 were positive for calbindin D28k but negative for calretinin, and 49 were positive for only calretinin in the double immunofluorescence microscopy. The nerve fibers associated with the taste buds and the free nerve endings, which immunostained for calbindin D28k, were not stained with antibody against calretinin. After injection of the fast blue in the laryngeal mucosa, fast blue-labeled cells were mainly observed in the nodose ganglia. Of the total number of labeled cell in the nodose and dorsal root ganglia at the level C1 to Th2, 65.1% occurred in nodose ganglia (572/879, n = 6). In the nodose ganglia, 79.7% of labeled cells (456/572) were immunoreacted for calbindin D28k. The distribution of calbindin D28k-immunoreactivity may be differnt from that of calretinin. It is suggested that calbindin D28k have regulatory role on intracellular calcium concentration in the laryngeal sensory corpuscles.  (+info)

1BOC: The solution structures of mutant calbindin D9ks, as determined by NMR, show that the calcium-binding site can adopt different folds.
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Calbindin je termín označující skupinu transportních proteinů v buňkách tenkého střeva a v ledvinách. Tyto proteiny jsou závislé na funkci vitaminu D a umožňují absorpci vápníku ze střeva a ledvinných tubulů do organizmu ...
1IG5: Structural basis for the negative allostery between Ca(2+)- and Mg(2+)-binding in the intracellular Ca(2+)-receptor calbindin D9k.
Fast delivery of PPM1K knockout Human Cell Lines for the study of gene function. Created by CRISPR/Cas9 genome editing. Includes matched wildtype control.
In Alzheimers disease and other degenerative brain diseases, some types of nerve cells are more vulnerable to degeneration than others. Nerve cells known as the basal forebrain cholinergic neurons (BFCN) are especially vulnerable. These cells are known to be important for memory and attention, both of which decline in patients with Alzheimers disease. Calbindin is a protein found inside nerve cells that binds to calcium. It protects nerve cells from abnormal increases in calcium, which can cause degeneration of the cell. Changiz Geula, Ph.D., and colleagues have found that the levels of calbindin decline in BFCN cells during normal aging. They theorize that such declines may leave the cells vulnerable to degeneration caused by abnormally high calcium levels.. Dr. Geula and colleagues plan to study the role of calbinin in Alzheimers disease using two approaches. In the first approach, they will study the levels of calbindin in the BFCN cells that remain in individuals affected by Alzheimers ...
The protein encoded by this gene is a member of the calcium-binding protein superfamily that includes calmodulin and troponin C. Originally described as a 27 kDa protein, it is now known to be a 28 kDa protein. It contains four active calcium-binding domains, and has two modified domains that are thought to have lost their calcium binding capability. This protein is thought to buffer entry of calcium upon stimulation of glutamate receptors. Depletion of this protein was noted in patients with Huntington disease. [provided by RefSeq, Jan 2015 ...
the equilibrium constant for a solubility reaction. A general solubility equation could be written as: MX (s) M+ (aq) + X- (aq) where MX represents an ionic solid, M+ the positive ion, and X- the negative ion. Since pure solids have an activity of 1, they are not included in equilibrium constant expressions. Therefore, the K expression for this reaction is: Since the concentration of either ion, [M+] or [Cl-] is the amount of MX that dissolved, (in other words, MXs solubility) and the result of multiplying two numbers is called a product, this kind of K expression is called a solubility product, and given the symbol Ksp. Therefore the K expression would normally be written ...
The structure of calbindin is characteristic of an EF-hand protein, with two helix-loop-helix calcium binding motifs joined by a flexible linker, and a short anti-parallel beta-type interaction between the two ion-binding sites. The structure of calbindin has been solved in the apo (Conformation 1), (Ca2+)(2) (Conformation 2), and (Cd2+)(1) (Conformation 3) states in x-ray and NMR studies. Upon binding of both Calcium ions to the structure, the two ion-binding loops in the structure move approximately 1.00 A together, while the pairs of helices in the structure move approximately 0.45 A together ...
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Disclaimer: TRIP Database staffs have endeavored to ensure the scientific accuracy of all entries to the database, but cannot take any responsibility for errors ...
DI-fusion, le Dépôt institutionnel numérique de lULB, est loutil de référencementde la production scientifique de lULB.Linterface de recherche DI-fusion permet de consulter les publications des chercheurs de lULB et les thèses qui y ont été défendues.
InitialConditions, ,ConcentrationSet region=dend, ,!-- calcium interacting proteins --, ,NanoMolarity specieID=Ca value=60/, ,!-- total calbindin = 160 uM --, ,NanoMolarity specieID=Calbin value=159980/, ,NanoMolarity specieID=CalbinC value=20/, ,!-- total calmodulin = 9000 nM (divide AC bound by 3.25)--, ,NanoMolarity specieID=Cam value=3590/, ,NanoMolarity specieID=CamCa2C value=126/, ,NanoMolarity specieID=CamCa2N value=20/, ,NanoMolarity specieID=CamCa4 value=0/, ,!-- total PP2B = 5000 nM--, ,NanoMolarity specieID=PP2B value=96 /, ,NanoMolarity specieID=PP2BCam value=3482 /, ,NanoMolarity specieID=PP2BCamCa2C value=1231 /, ,NanoMolarity specieID=PP2BCamCa2N value=181 /, ,NanoMolarity specieID=PP2BCamCa4 value=10 /, ,NanoMolarity specieID=L value=2.0/, ,NanoMolarity specieID=ATP value=1998000.0/, ,NanoMolarity specieID=cAMP value=89.0/, ,NanoMolarity specieID=AMP value=0.0/, ,NanoMolarity specieID=Epac1cAMP value=35.0/, ...
We investigated, by in situ hybridization histochemistry, the cellular localization of the mRNA encoding a vitamin D-dependent calcium-binding protein (calbindin D28) in rat brain and peripheral organs. Using a [35S]cRNA probe under high stringency conditions, specific mRNA was found in tissues well …
Recombinant human Calbindin D9K was cloned from bovine cDNA and expressed inE.coli. It bounds to one Ca and one Ln ion. Two calcium ions are bound in the Calbindin D9K version. The protein consists of Calbindin D9K, mutant P47M (residues 5-79, swissprot a
Although Calbindin-D9k (CaBP-9k), a cytosolic calcium binding protein which has calcium binding sites, is expressed in various tissues, i.e., intestine, uterus, and placenta, potential roles of this...
The vomeronasal organs (VNOs) of two humans, a male neonate and a female adult, were examined for immunolocalization of calbindin-D28k (calbindin) which has been immunolocalized to VNO receptor cells in other mammals. The present study demonstrates that epithelial cells within the VNOs of both subjects expressed calbindin-like immunoreactivity. These results suggest that human VNO epithelial cells of both genders express calbindin during development and in the adult.
1α,25-Dihydroxyvitamin D3 [1,25(OH)2D3] is known to modulate Ca2+ metabolism in several cell types. Vitamin-D-dependent calcium binding proteins such as calbindin-D28K (28 kDa calcium binding proteins) have been shown to be regulated by 1,25(OH)2D3 but the mechanisms controlling calbindin synthesis are still poorly understood in human osteoblast cell culture models. The human bone marrow stromal cells (HBMSC) described in this paper developed a calcified matrix, expressed osteocalcin (OC), osteopontin (OP) and responded to 1,25(OH)2D3. The expression of vitamin D receptor mRNA was demonstrated by reverse transcription-PCR. Calbindin-D28K protein was identified only in cells arising from the sixth subculture, which exhibited a calcified matrix and all of the osteoblastic markers, e.g. OC and OP. It was demonstrated by dot-immunodetection using immunological probes, and by in situ hybridization using labelled cDNA probes. Moreover, vitamin D3 enhanced calbindin-D28K synthesis as well as OC ...
Attention‐deficit/hyperactivity disorder (ADHD) is a developmental disorder characterized by hyperactivity, inattention, and impulsive behaviors and has significant societal impact. ADHD is recognized as a heterogeneous disease, and genetic and/or environmental factors underlying pathogenesis remain largely unknown. There is an obvious need to increase knowledge on molecular signaling and brain pathways underlying disease development, and genetic mouse models are key to this goal. In this issue of EMBO Molecular Medicine, DAndrea et al (2015) combine state‐of‐the‐art genetic and behavioral approaches in the mouse to demonstrate an essential role for PI3Kγ and cAMP homeostasis in ADHD‐related behaviors, through signaling mechanisms operating at the level of the locus coeruleus, the main source of noradrenaline in the brain. Furthermore, the study posits PI3Kγ knockout mice as a novel tool of high interest for modeling ADHD endophenotypes.. See also: I DAndrea et al (July 2015) ...
Worldwide expansion of mobile phones and electromagnetic field (EMF) exposure has raised question of their possible biological effects on the brain and nervous system. Radiofrequency (RF) radiation might alter intracellular signaling pathways through changes in calcium (Ca(2+)) permeability across cell membranes. Changes in the expression of calcium binding proteins (CaBP) like calbindin D28-k (CB) and calretinin (CR) could indicate impaired Ca(2+)homeostasis due to EMF exposure. CB and CR expression were measured with immunohistochemistry in the hippocampus of mice after EMF exposure at 835 MHz for different exposure times and absorption rates, 1 h/day for 5 days at a specific absorption rate (SAR)=1.6 W/kg, 1 h/day for 5 days at SAR=4.0 W/kg, 5 h/day for 1 day at SAR=1.6 W/kg, 5 h/day for 1 day at SAR=4.0 W/kg, daily exposure for 1 month at SAR=1.6 W/kg. Body weights did not change significantly. CB immunoreactivity (IR) displayed moderate staining of cells in the cornu ammonis (CA) areas and ...
At least three CaBPs are abundant in various types of nerve cells : calbindin-D28, calretinin, and parvalbumin. The sequence of chick calretinin, from cDNA clones, is 60% homologous to that of chick...
DAB staining of tissue with this antibody showed high specificity and very low background at a concentration of 1:2000. For fluorescence staining of tissue. the optimal concentration was 1:1000.. This was also tested on neurons in culture where a clear difference between Calbindin-positive and -negative was seen at a concentration of 1:1000.. This was not tested for IP or WB.. ...
Shortall, S. E., Brown, A. M., Newton-Mann, E., Dawe-Lane, E., Evans, C., Fowler, M., & King, M. V. (2020). Calbindin Deficits May Underlie Dissociable Effects of 5-HT6 and mGlu7 Antagonists on Glutamate and Cognition in a Dual-Hit Neurodevelopmental Model for Schizophrenia. Molecular Neurobiology, https://doi.org/10.1007/s12035-020-01938-x © 2020, The Author(s). Despite several compounds entering clinical trials for the negative and cognitive symptoms of schizophrenia, few have progressed beyond phase III. This is partly attributed to a need for improved preclinical models, to understa... Read More about Calbindin Deficits May Underlie Dissociable Effects of 5-HT6 and mGlu7 Antagonists on Glutamate and Cognition in a Dual-Hit Neurodevelopmental Model for Schizophrenia. ...
Rabbit Polyclonal Anti-Calbindin D-28K Antibody - Pre-diluted. Validated: IHC, IHC-P. Tested Reactivity: Human, Mouse, Rat. 100% Guaranteed.
Citation counts are provided from Web of Science and CrossRef. The counts may vary by service, and are reliant on the availability of their data. Counts will update daily once available.. ...
Many patients who have coronary artery disease also have plaque build-up in other vessels of the body. In the cath lab, physicians at Bay Medical can use this same technology for widening the clogged vessels that lead to the legs and in the renal arteries that lead to the kidneys. In the carotid arteries that lead to the brain, plaque build-up is a major risk factor for stroke. In this delicate area, a special stent is used to open up this vessel that has embolic protection - a small basket-like device that is downstream from the stent to catch any debris from the procedure so that it does not travel up the blood stream and into the brain.. ...
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Vitamin D-dependent calcium binding proteins were discovered in the cytosolic fractions of chicken intestine, and later in mammalian intestine and kidney, by workers including Robert Wasserman of Cornell University. They bound calcium in the micromolar range and were greatly reduced in vitamin D-deficient animals. Expression could be induced by treating these animals with vitamin D metabolites such as calcitriol. They were found to exist in two distinct sizes with a molecular weight of approximately 9 kDa and 28 kDa. They were renamed calbindin. Calbindin-D9k (S100G) is found in mammalian intestine and calbindin-D28k is in avian intestine and in mammalian kidney and other tissues. Calcium-binding protein Wasserman, RH; Taylor, AN (1966). Vitamin D3-induced calcium-binding protein in chick intestinal mucosa. Science. 152 (3723): 791-3. doi:10.1126/science.152.3723.791. PMID 17797460. Wasserman, RH; Corradino, RA; Taylor, AN (1969). Binding proteins from animals with possible transport ...
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Calcium binding protein information including symptoms, causes, diseases, symptoms, treatments, and other medical and health issues.
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pep:known chromosome:VEGA66:3:90511034:90514392:-1 gene:OTTMUSG00000022107 transcript:OTTMUST00000052482 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:S100a1 description:S100 calcium binding protein A1 ...
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Full text for this publication is not currently held within this repository. Alternative links are provided below where available. ...
Cell-cell interactions play crucial roles in the maintenance of tissue homeostasis, a loss of which often leads to varying diseases, including cancer. Here, we report that uncontrolled PI3K activity within oocytes irreversibly transforms granulosa cells (GC), causing GC tumors (GCT) through perturbed local cell-communication. Previously, we reported reproductive phenotypes of transgenic mice, in which expression of constitutively active mutant PI3K was induced in primordial oocytes by Gdf9-iCre. The transgenic mice (Cre+) demonstrated severe ovarian phenotypes, including the overgrowth of excess ovarian follicles and anovulation. Surprisingly, the Cre+ mice became cachectic by postnatal day 80 due to bilateral GCT. Although GCT cells proliferated independently of oocytes, local interactions with mutant PI3K-positive oocytes during early folliculogenesis were essential for the GC transformation. Growing GCT cells expressed high levels of inhibin βA and nuclear SMAD3, and the proliferation rate ...
The present investigation has demonstrated that ionizing radiation in the therapeutic dose range stimulates a transient cellular generation of ROS/RNS. Temporally coincident is a radiation-induced reversible depolarization of the mitochondrial ΔΨ and decrease in mitochondrial entrapped calcein fluorescence, both hallmarks of the mitochondrial permeability transition. The amount of ROS/RNS generated is relatively constant over the dose range tested, but the number of cells that respond increases with the dose. The radiation-induced ROS/RNS generation, ΔΨ depolarization, and calcein release are inhibited by CsA but not by the structural analogue, CsH. Overexpression of the Ca2+-binding protein calbindin 28K or treatment of cells with BAPTA/AM, an intracellular Ca2+ chelator, also effectively block radiation-induced ROS/RNS. The increased ROS/RNS generation observed with radiation is common to all of the cell types examined but for one important exception, the mitochondrial DNA-less ρo ...
p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.,/p> ,p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.,/p> ,p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).,/p> ,p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x,sup>64,/sup> + x,sup>4,/sup> + x,sup>3,/sup> + x + 1. The algorithm is described in the ISO 3309 standard. ,/p> ,p class=publication>Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.,br /> ,strong>Cyclic redundancy and other checksums,/strong>,br /> ,a href=http://www.nrbook.com/b/bookcpdf.php>Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993),/a>),/p> Checksum:i ...
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice. ...
Looking for online definition of S100 calcium binding protein A3 in the Medical Dictionary? S100 calcium binding protein A3 explanation free. What is S100 calcium binding protein A3? Meaning of S100 calcium binding protein A3 medical term. What does S100 calcium binding protein A3 mean?
Animals. Two strains of transgenic mice, each bearing a jellyfish green fluorescent protein (GFP) reporter, were used. The mPer1::d2EGFP transgenic mouse (termed here Per1::GFP; a gift from Dr. D. McMahon, Vanderbilt University, Nashville, TN) was made with the B6C3F1 hybrid mouse as described previously (Kuhlman et al., 2000). The mice used in the present studies were hemizygous for the d2EGFP transgene, which is a degradable form of GFP.. The calbindin-D28K-bacterial artificial chromosome (BAC)::GFP transgenic mouse (termed here CalB::GFP; a gift from Dr. N. Heintz, Rockefeller University, New York, NY) was made by insertion of enhanced GFP (EGFP) (Yang et al., 1997) in the calbindin BAC (Research Genetics/Invitrogen, Carlsbad, CA) by homologous recombination. The homologous region was upstream of the start codon of the calbindin gene. The first stretch of the sequence included the calbindin-D28K promoter followed by the first linker sequence and then the EGFP construct followed by the second ...
Neocortical neurones can be classified according to several independent criteria: morphological, physiological, and molecular expression (neuropeptides (NPs) and/or calcium-binding proteins (CaBPs)). While it has been suggested that particular NPs and CaBPs characterize certain anatomical subtypes of neurones, there is also considerable overlap in their expression, and little is known about simultaneous expression of multiple NPs and CaBPs in morphologically characterized neocortical neurones. Here we determined the gene expression profiles of calbindin (CB), parvalbumin (PV), calretinin (CR), neuropeptide Y (NPY), vasoactive intestinal peptide (VIP), somatostatin (SOM) and cholecystokinin (CCK) in 268 morphologically identified neurones located in layers 2-6 in the juvenile rat somatosensory neocortex. We used patch-clamp electrodes to label neurones with biocytin and harvest the cytoplasm to perform single-cell RT-multiplex PCR. Quality threshold clustering, an unsupervised algorithm that clustered
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S100B (S100 calcium binding protein B), Authors: M Rosario Fernandez-Fernandez, Alan R Fersht. Published in: Atlas Genet Cytogenet Oncol Haematol.
The idea of Professors Bolis and Gilles to gather together for a 3 days meeting in the splendid environment of Crans-Montana in Switzerland a limited number of people around the subject of calcium an
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Parvalbumin alpha / PVALB, 0.1 ml. Parvalbumin?is a?calcium-binding?albumin?protein with low molecular weight (typically 9-11 kDa).
Recombinant protein of human S100 calcium binding protein A11 (S100A11), 20 ug available for purchase from OriGene - Your Gene Company.
"Entrez Gene: calbindin 2". Parmentier M, Passage E, Vassart G, Mattei MG (1991). "The human calbindin D28k (CALB1) and ... Calretinin, also known as calbindin 2 (formerly 29 kDa calbindin), is a calcium-binding protein involved in calcium signaling. ... Expression was found in different neurons than that of the similar vitamin D-dependent calcium-binding protein, calbindin-28kDa ... 88 (1): 76-86. doi:10.1016/j.eplepsyres.2009.09.021. PMID 19854615. S2CID 22595044. Mai KT, Teo I, Al Moghrabi H, Marginean EC ...
Calbindin is a protein involved in calcium ion transport within cells, and excess calcium in cells is toxic. The calbindin ... Secondly, dopaminergic neurons in the pars compacta contain less calbindin than other dopaminergic neurons. ... "Midbrain dopaminergic neurons in the mouse that contain calbindin-D28k exhibit reduced vulnerability to MPTP-induced ... 2 (1): 1-14. doi:10.1007/BF02251241. PMID 2357268. Kim SJ, Sung JY, Um JW, Hattori N, Mizuno Y, Tanaka K, Paik SR, Kim J, Chung ...
Calcium influx from the diet and its subsequent binding to calbindin-D9k could be the rate-limiting step that modulates vitamin ... Koo TH, Yang H, Jeung EB (2011-07-01). "Expression of Calcium Transport Genes in the Placenta of Calbindin-D9k and -D28k ... TRPV6 is known to co-localize with TRPV5 Calbindin-D28K in apical domains of distal convoluted tubules and connecting tubules [ ... In many rodent lines, genetic variations in TRPV6, calbindin-D9k, PMCA1b mRNA influence intestinal Ca absorption and its impact ...
The VL is stained for calbindin and acetylcholinesterase. The axons ascend in the nucleus where they branch profusely. The VL ... François, C.; Yelnik, J.; Percheron, G.; Tandé, D. (1994). "Calbindin-D-28K as a marker of the associative coertical territory ... 54 (1): 11-23. doi:10.1002/syn.20060. PMID 15300880. S2CID 25253890. Munro-Davies, L.E.; Winter, J.; Aziz, T.Z.; Stein, J.F ( ... ISBN 1-4160-3445-5.CS1 maint: multiple names: authors list (link) Arrechi-Bouchhiouia et al.1996 Arrechi-Bouchhiouia et al.1997 ...
Those in the upper layer (or dorsal tier) contain a binding protein called calbindin-D28K which can buffer calcium levels ... Nemoto, C.; Hida, T.; Arai, R. (1999-10-30). "Calretinin and calbindin-D28k in dopaminergic neurons of the rat midbrain: a ... "Calbindin content and differential vulnerability of midbrain efferent dopaminergic neurons in macaques". Frontiers in ... 846 (1): 129-136. doi:10.1016/s0006-8993(99)01950-2. ISSN 0006-8993. PMID 10536220. Dopeso-Reyes, Iria G.; Rico, Alberto J.; ...
The latter group is represented by calbindin D9k and do not undergo calcium dependent conformational changes. EPS15 homology ( ... and Ca2+ buffers such as calreticulin and calbindin D9k. While the majority of the known EF-hand Calcium-binding proteins ( ... 135 (1): 110-22. doi:10.1016/j.cell.2008.08.006. PMID 18854159. Nelson MR, Thulin E, Fagan PA, Forsén S, Chazin WJ (February ... 3 (1): 7-11. doi:10.1016/S0969-2126(01)00130-7. PMID 7743133. Stathopulos PB, Zheng L, Li GY, Plevin MJ, Ikura M (October 2008 ...
Other calcium-binding protein markers are calretinin (most abundant subtype in DLPFC, about 50%) and calbindin. Interneurons ... calbindin D-28k or parvalbumin in monkey prefrontal cortex: distribution and morphology". The Journal of Comparative Neurology ... the role of the calcium-binding proteins calbindin D-28k, calretinin and parvalbumin, in cerebellar physiology. Studies with ... 24 (1): 289-95. doi:10.1016/0010-406x(68)90978-x. PMID 5645516. Parvalbumins at the US National Library of Medicine Medical ...
"Choline deficiency alters global histone methylation and epigenetic marking at the Re1 site of the calbindin 1 gene". FASEB J. ... 70 (1): 73-81. doi:10.1017/S0029665110003988. PMID 21110912. Jensen CB, Storgaard H, Dela F, Holst JJ, Madsbad S, Vaag AA (Apr ... 690 (1): 71-80. doi:10.1016/j.mrfmmm.2010.02.006. PMID 20188748.CS1 maint: multiple names: authors list (link) Zeisel S (2011 ... Lond.). 566 (Pt 1): 225-36. doi:10.1113/jphysiol.2005.086462. PMC 1464716. PMID 15860532.CS1 maint: multiple names: authors ...
A specific, recognizable feature of Purkinje neurons is the expression of calbindin. Calbindin staining of rat brain after ... Whitney ER, Kemper TL, Rosene DL, Bauman ML, Blatt GJ (February 2008). "Calbindin-D28k is a more reliable marker of human ... 10 (1-2): 25-61. CiteSeerX 10.1.1.14.7524. doi:10.1016/0025-5564(71)90051-4. Purves D, Augustine GJ, Fitzpatrick D, Hall WC, ... 65 (1): 14-27. doi:10.1016/j.brainresrev.2010.05.005. PMC 2943015. PMID 20553761. Baumann O, Borra RJ, Bower JM, Cullen KE, ...
Vitamin D also increases transcription of genes that code for Calbindin. As the name implies, Calbindin functions as a calcium- ... The Section 5(1) of the Food and Drugs Act requires that all health claims be truthful and not misleading or deceptive. The ... 1)Increases re-absorption of Ca++ from the kidneys and gastrointestinal tract(GI) 2)Releases calcium from bones into the blood ...
Alternating compartments of dense Cat-301 and calbindin immunore- activity in layer 4A". Cerebral Cortex. 12 (7): 671-691. doi: ... 1: 7-23. doi:10.1023/A:1010028405318. S2CID 142597701. Preuss M and Coleman Q (2002). "Human-specific organization of primary ...
This gene encodes calbindin D9K, a vitamin D-dependent calcium-binding protein. This cytosolic protein belongs to a family of ... Jeung EB, Krisinger J, Dann JL, Leung PC (Sep 1992). "Molecular cloning of the full-length cDNA encoding the human calbindin- ... 2004). "Control of differentiation-induced calbindin-D9k gene expression in Caco-2 cells by cdx-2 and HNF-1α". Am. J. Physiol. ... Howard A, Legon S, Spurr NK, Walters JR (1992). "Molecular cloning and chromosomal assignment of human calbindin-D9k". Biochem ...
IMPA1 has been shown to interact with Bergmann glial S100B and calbindin. L-690,330 is a competitive inhibitor of IMPase ... Schmidt H, Schwaller B, Eilers J (April 2005). "Calbindin D28k targets myo-inositol monophosphatase in spines and dendrites of ... Berggard T, Szczepankiewicz O, Thulin E, Linse S (2003). "Myo-inositol monophosphatase is an activated target of calbindin D28k ... "Myo-inositol monophosphatase is an activated target of calbindin D28k". J. Biol. Chem. 277 (44): 41954-9. doi:10.1074/jbc. ...
Lee, Y. S.; Taylor, A. N.; Reimers, T. J.; Edelstein, S.; Fullmer, C. S.; Wasserman, R. H. (1987). "Calbindin-D in peripheral ... Fullmer, C. S.; Wasserman, R. H. (1987). "Chicken intestinal 28-kilodalton calbindin-D: Complete amino acid sequence and ... known today as calbindin. In the mid-1970s, Wasserman developed an interest in the hypercalcemic effects of extracts of the ... calbindin-D28k, and parvalbumin in Purkinje cells of avian and mammalian cerebellum". Proceedings of the National Academy of ...
Woo TU, Shrestha K, Lamb D, Minns MM, Benes FM (April 2008). "N-Methyl-D-Aspartate Receptor and Calbindin-Containing Neurons in ... calbindin, targeting the dendrites of pyramidal neurons, and the expression of the mRNA for the GluR5 kainate receptor in GABA ... 5 (1): 3. doi:10.1038/scibx.2012.3. Chez MG, Burton Q, Dowling T, Chang M, Khanna P, Kramer C (May 2007). "Memantine as ... 96 (1-3): 46-61. doi:10.1016/j.schres.2007.06.023. PMC 2712609. PMID 17698324. de Lucena D, Fernandes BS, Berk M, et al. ( ...
"Calbindin 1, fibroblast growth factor 20, and alpha-synuclein in sporadic Parkinson's disease". Hum. Genet. 124 (1): 89-94. doi ... 28 Suppl 1: S67-72. doi:10.1007/s10875-007-9160-5. PMID 18193341. S2CID 5965278. Kardon T, Senesi S, Marcolongo P, Legeza B, ... 2,4-dienoyl-CoA reductase 1 is a protein that in humans is encoded by the DECR1 gene. This gene encodes an accessory enzyme ... "Entrez Gene: 2,4-dienoyl-CoA reductase 1". Retrieved 2017-09-12. Alphey MS, Yu W, Byres E, Li D, Hunter WN (2005). "Structure ...
A specific, recognizable feature of Purkinje neurons is the expression of calbindin.[20] Calbindin staining of rat brain after ... Whitney ER, Kemper TL, Rosene DL, Bauman ML, Blatt GJ (February 2008). "Calbindin-D28k is a more reliable marker of human ... doi:10.1007/s00422-008-0217-1. PMID 18491162.. *^ Bower JM (1997). Is the cerebellum sensory for motor's sake, or motor for ... 978-1-84169-044-5. .. *^ a b Doya K (December 2000). "Complementary roles of basal ganglia and cerebellum in learning and motor ...
... calbindin -calcitonin - calcitonin gene-related peptide - calcitonin gene-related peptide receptor - calcitonin receptor - ... IGF type 1 receptor - IGF type 2 receptor - IgG - IgM - immediate-early protein - immune cell - immune system - immunoglobulin ... alpha-1 adrenergic receptor - alpha-2 adrenergic receptor - alpha-beta T-cell antigen receptor - alpha-fetoprotein - alpha- ... endothelin-1 - energy decomposition cycles - energy level - enhancer - enkephalin - Enthalpy - entomology - Entropy - env gene ...
... by the intestine via calbindin. PTH was one of the first hormones to be shown to use the G-protein, adenylyl cyclase second ... Parathyroid hormone 1 receptors, activated by the 34 N-terminal amino acids of PTH, are present at high levels on the cells of ... 128 (1): 9-13. doi:10.1016/j.cell.2006.12.018. PMID 17218247. S2CID 18872015. White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, ... hPTH-(1-34) crystallizes as a slightly bent, long, helical dimer. The extended helical conformation of hPTH-(1-34) is the ...
... and calbindin. A small number of HSD2 neurons (less than 2%) may express the neuropeptide galanin. Their lack of expression of ... 42 (1): 1-23. doi:10.1016/j.jchemneu.2011.05.003. PMC 3148274. PMID 21605659. Dong, HW; Petrovich, GD; Watts, AG; Swanson, LW ( ... 1115 (1): 54-64. doi:10.1016/j.brainres.2006.07.091. PMID 16935272. Geerling, JC; Kawata, M; Loewy, AD (Jan 20, 2006). " ... Geerling, JC; Loewy, AD (Aug 1, 2006). "Aldosterone-sensitive neurons in the nucleus of the solitary tract: bidirectional ...
... s express somatostatin and sometimes calbindin, but not parvalbumin or vasoactive intestinal peptide. ... 561 (Pt 1): 65-90. doi:10.1113/jphysiol.2004.073353. PMC 1665344. PMID 15331670. Sugino K, Hempel CM, Miller MN, et al. ( ... 9 (1): 99-107. doi:10.1038/nn1618. PMID 16369481. S2CID 27815855. Hilscher, Markus M.; Leão, Richardson N.; Edwards, Steven J ...
It is encoded in humans by the CALB2 gene and was formerly known as calbindin-D29k. S100G, formerly calbindin 3 and calbindin- ... Calbindins are three different calcium-binding proteins: calbindin, calretinin and S100G. They were originally described as ... Calbindin acts as a calcium buffer and calcium sensor and can hold four Ca2+ in the EF-hands of loops EF1, EF3, EF4 and EF5. ... Calbindin 1 or simply calbindin was first shown to be present in the intestine in birds and then found in the mammalian kidney ...
... is a protein that in humans is encoded by the CALB1 gene. It belongs to the calbindin family of calcium-binding ... "Entrez Gene: Calbindin 1". Retrieved 2018-10-04. Noble JW, Almalki R, Roe SM, Wagner A, Duman R, Atack JR (October 2018). "The ... Bauer MC, Nilsson H, Thulin E, Frohm B, Malm J, Linse S (April 2008). "Zn2+ binding to human calbindin D(28k) and the role of ... Tao L, Murphy ME, English AM (May 2002). "S-nitrosation of Ca(2+)-loaded and Ca(2+)-free recombinant calbindin D(28K) from ...
... by the intestine via calbindin. ... Low or Low Normal [note 1]. High *^ a b c Low Normal or Normal ... 978-0-07-162243-1. .. *^ Agus ZS (Jul 1999). "Hypomagnesemia". Journal of the American Society of Nephrology. 10 (7): 1616-22. ... 1 (2): 149-52. doi:10.1038/ng0592-149. PMID 1302009.. *. Handt O, Reis A, Schmidtke J (Nov 1992). "Ectopic transcription of the ... 56 (1): 470-3. doi:10.1002/hlca.19730560139. PMID 4721748.. *. Jacobs JW, Kemper B, Niall HD, Habener JF, Potts JT (May 1974 ...
... including calbindins and S100G Vitamin D resistant rickets, X-linked hypophosphatemia, a form of rickets for which ingestion of ... 1,25-dihydroxyvitamin D or 1,25(OH)2D), the active hormonal form of vitamin D Calcitroic acid (1,24,25-trihydroxyvitamin D), ...
The territory is stained for calbindin. The mediator of the pallido-thalamic connection is the inhibitor GABA. The ... The stratae 1 and 2, the most ventral, are magnocellular. The other are mediocellular. From the retina, the axons of the optic ... The thalamocortical axons of the VPC send their axons to the primary somatosensory area (areas 3b and 1) where there is also a ... Retinal axons from the controlateral retina end in stratae 1,4 and 6. Those from the ipsilateral retina end in 2,3 and 5. The ...
In the rat, few also express calbindin (CB) or calretinin (CR). Many of the DTN GABAergic cells do express parvalbumin (PV) ... 187 (1): 19-47. doi:10.1002/cne.901870103. PMID 226566. Allen GV, Hopkins DA (1989). "Mamillary body in the rat: topography and ... 630 (1-2): 188-94. doi:10.1016/0006-8993(93)90656-8. PMID 8118685. Dillingham CM, Holmes JD, Wright NF, Erichsen JT, Aggleton ... 53 (1): 254-66. doi:10.1016/0014-4886(76)90295-8. PMID 964341. MOREST DK (1961). "Connexions of the dorsal tegmental nucleus in ...
Lutz W, Frank EM, Craig TA, Thompson R, Venters RA, Kojetin D, Cavanagh J, Kumar R (2003). "Calbindin D28K interacts with Ran- ... 297 (1): 148-53. doi:10.1016/S0006-291X(02)02020-X. PMID 12220523. Rao MA, Cheng H, Quayle AN, Nishitani H, Nelson CC, Rennie ... J. 367 (Pt 1): 87-95. doi:10.1042/BJ20011851. PMC 1222860. PMID 12084015. Wang D, Li Z, Messing EM, Wu G (2002). "Activation of ... 297 (1): 148-53. doi:10.1016/S0006-291X(02)02020-X. PMID 12220523. Umeda M, Nishitani H, Nishimoto T (Jan 2003). "A novel ...
Calbindin is expressed by cerebellar Purkinje cells and granule cells of the hippocampus. The reorganization and migration of ... calbindin-stained Purkinje neurons in rat cerebellum after peripheral nerve injury suggests that calbindin may be a marker for ... ISBN 978-1-4615-9488-8. Purves, D., Augustine, G.J., Fitzpatrick, D., LaMantia, Anthony-Samuel, Hall, W.C., White, L.E. (2012 ... doi:10.1007/978-1-61779-005-8_7. ISBN 978-1-61779-004-1. PMID 21431737. Graus, F.; Ferrer, I. (1990). "Analysis of a neuronal ...
VTA neurons are protective against MPP+ insult due to the expression of calbindin. Calbindin regulates the availability of Ca2+ ... MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) is a prodrug to the neurotoxin MPP+, which causes permanent symptoms of ... 1 (3): 249-254. doi:10.1016/0165-1781(79)90006-4. PMID 298352. "Success reported using fetal tissue to repair a brain". The New ... 2 (1): 141-151. doi:10.1038/nprot.2006.342. PMID 17401348. "Pesticides and Parkinson's Disease - A Critical Review" (PDF). ...
This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it. *v ... 266 (1): 391-8. PMID 1985907.. *^ a b c Gryoke, Sandor (2003). "Calsequestrin determines the functional size and stability of ... Each molecule of calsequestrin can bind 18 to 50 Ca2+ ions.[1] Sequence analysis has suggested that calcium is not bound in ... is present in cardiac and slow skeletal muscle and the fast skeletal form Calsequestrin-1(CASQ1) is found in fast skeletal ...
... calbindin expressed in distal tubules and aquaporin 2 expressed in the collecting duct cells.[14] ... ISBN 978-1-58829-081-6.. *^ a b Post TW, Rose BD, auths and Curhan GC, Sheridan AM, eds. Diagnostic Approach to the Patient ... 160 (1): 83-6. doi:10.2214/ajr.160.1.8416654.. *^ Clapp, WL. "Renal Anatomy". In: Zhou XJ, Laszik Z, Nadasdy T, D'Agati VD, ... 1] Archived February 10, 2008, at the Wayback Machine. *^ Glodny B, Unterholzner V, Taferner B, et al. (2009). "Normal kidney ...
... or calbindin-immuno-reactive neurons (CIR neurons), are widely distributed and diffusely dispersed in each of the nuclei of the ... 42 (1): 27-37. doi:10.1016/S0361-9230(96)00107-4.. *^ a b Gibbs J.W.; Zhang Y.; Shumate M.D.; Coulter D.A. (1999). "Regionally ... 149 (1): 173-185. doi:10.1016/S0079-6123(05)49013-5.. *^ Afifi A.K.; Bergman R.A. (December 1, 1997). Functional neuroanatomy. ... 1° (Free nerve ending → A delta fiber) → 2° (Anterior white commissure → Lateral and Anterior Spinothalamic tract → Spinal ...
It is related to calbindin D-28K and calretinin. This protein is thought to be involved in potassium chloride-stimulated ...
骨化三醇通过激活维生素D受体发挥生物学效应,VDR存在于靶细胞表面,[4]活化的VDR可以作为转录因子,调节运载蛋白(如TRPV6和Calbindin)的表达,参与小肠内钙的吸收。[17] ... 维生素D3由紫外線照射7-脱氢胆
Calbindin. *Calcineurin. *Calcitonin gene-related peptide. *Calcium-activated potassium channel subunit alpha-1 ...
... such as TRPV6 and calbindin), which are involved in calcium absorption in the intestine.[17] The vitamin D receptor belongs to ... 3 (1-2): 73-7. doi:10.1023/A:1015263514765. PMID 12014847.. *^ a b c d e f Holick MF (July 2007). "Vitamin D deficiency". The ... 32 (1): 13-22. doi:10.3177/jnsv.32.13. PMID 3012050.. *^ a b c d Adams JS, Hewison M (February 2010). "Update in vitamin D". ... "Evidence Report/Technology Assessment (183): 1-420. PMC 4781105. PMID 20629479.. *^ a b c d Bjelakovic G, Gluud LL, Nikolova D ...
... such as TRPV6 and calbindin), which are involved in calcium absorption in the intestine.[19] The vitamin D receptor belongs to ... 32 (1): 13-22. doi:10.3177/jnsv.32.13. PMID 3012050.. *^ a b c d Adams JS, Hewison M (February 2010). "Update in vitamin D". ... 1): CD007470. doi:10.1002/14651858.CD007470.pub3. PMID 24414552.. *^ a b c d e f g Bolland MJ, Grey A, Gamble GD, Reid IR ( ... 58 (1): 4-5. doi:10.1007/BF02509538. PMID 8825231. S2CID 35887181.. *^ a b Holick MF, Schnoes HK, DeLuca HF (April 1971). " ...
... such as calbindin, calretinin and parvalbumin. CR cells express several genes important in corticogenesis, such as reelin (RELN ... 17 (1): 23-31. PMID 8987733. Ogawa M, Miyata T, Nakajima K, et al. (May 1995). "The reeler gene-associated antigen on Cajal- ... 20 (1): 101-5. doi:10.1016/0168-0102(94)90027-2. PMID 7984336. Hevner RF, Neogi T, Englund C, Daza RA, Fink A (March 2003). " ... 141 (1-2): 39-53. doi:10.1016/S0165-3806(02)00641-7. PMID 12644247. Meyer G, Soria JM, Martínez-Galán JR, Martín-Clemente B, ...
... this is particularly evident on the components of acetylcholinesterase and calbindin. More studies have been carried out on the ... Table 1 McDonald, M-L; MacMullen, C; Liu, D J; Leal, S M; Davis, R L (2 October 2012). "Genetic association of cyclic AMP ... 43 (1): 133-143. doi:10.1016/j.neuron.2004.06.012. PMID 15233923. Bergson, C; Mrzljak, L; Smiley, JF; Pappy, M; Levenson, R; ... 64 (1): 20-4. doi:10.1001/archneur.64.1.20. PMID 17210805. Nestler EJ (December 2013). "Cellular basis of memory for addiction ...
... calbindin expressed in distal tubules and aquaporin 2 expressed in the collecting duct cells. The mammalian kidney develops ... ISBN 978-1-4160-2328-9. Clapp, WL. "Renal Anatomy". In: Zhou XJ, Laszik Z, Nadasdy T, D'Agati VD, Silva FG, eds. Silva's ... 1] Archived February 10, 2008, at the Wayback Machine Glodny B, Unterholzner V, Taferner B, et al. (2009). "Normal kidney size ... doi:10.1007/978-1-59745-016-4_16. ISBN 978-1-58829-081-6. PMC 4869439. GAITONDE, David Y (15 December 2017). "Chronic Kidney ...
... and calbindin (25%) and resembles alpha-parvalbumin in its N-terminal region (52%). It has a 40-residue N-terminal domain with ... 216 (1): 127-40. doi:10.1016/S0022-2836(05)80065-8. PMID 2231727. Kurimoto, Takuji; Yin, Yuqin; Habboub, Ghaith; Gilbert, Hui- ...
Vo T. T. B., Jeung E. B. (2009) An Evaluation of Estrogenic Activity of Parabens Using Uterine Calbindin-D9k Gene in an ... 68: 1-11. Mao Q., Ji F., Wang W., Wang Q., Hu Z., Yuan S. (2016) Chlorination of parabens: reaction kinetics and transformation ... In an in vivo study, the effect of butylparaben was determined to be about 1/100,000th that of estradiol, and was only observed ... 80 (1): 49-60. doi:10.1016/S0960-0760(01)00174-1. PMID 11867263. S2CID 6667945. Edwin J. Routledge; et al. (1998). "Some alkyl ...
... by their expression of calbindin and calretinin. In the reeler DG, the two cell types intermingle. Impaired dendrite outgrowth ... 41 (1): 71-84. doi:10.1016/s0896-6273(03)00819-5. PMID 14715136. Matsuzaki H, Minabe Y, Nakamura K, Suzuki K, Iwata Y, Sekine Y ... 11 (1-2): 45-58. doi:10.3109/01677069609107062. PMID 10876649. Ammassari-Teule M, Sgobio C, Biamonte F, Marrone C, Mercuri NB, ...
... the last being calbindin positive. The ventral tier is considered as A9v. The dorsal tier A9d is linked to an ensemble ... 289 (1): 36-52. doi:10.1002/cne.902890104. PMID 2572613.CS1 maint: multiple names: authors list (link) Cragg S.J.; Baufreton J ...
Among GABAergic interneurons, reelin seems to be detected predominantly in those expressing calretinin and calbindin, like ... 112 (1-2): 33-45. doi:10.1016/S0169-328X(03)00032-9. PMID 12670700. Hack I, Hellwig S, Junghans D, Brunne B, Bock HH, Zhao S, ... 1 (2): 72-73. doi:10.1046/j.1535-7597.2001.00017.x. PMC 320825. PMID 15309195. Zaki M, Shehab M, El-Aleem AA, Abdel-Salam G, ... beta-1 integrin receptors on glial cells play more important role in neuronal layering than the same receptors on the migrating ...
calbindin. Names. RTVL-H protein. calbindin 1, (28kD). calbindin 1, 28kDa. calbindin 27. calbindin D28. vitamin D-dependent ... CSF calbindin concentration is a sensitive biomarker of NPC1 disease Title: Cerebrospinal Fluid Calbindin D Concentration as a ... calbindin 1provided by HGNC. Primary source. HGNC:HGNC:1434 See related. Ensembl:ENSG00000104327 MIM:114050 Gene type. protein ... Calbindin-D28K immunoreactivity in the human cerebellar cortex. Flace P, et al. Anat Rec (Hoboken), 2014 Jul. PMID 24719368 ...
Calbindin 1 is a protein that in humans is encoded by the CALB1 gene. It belongs to the calbindin family of calcium-binding ... "Entrez Gene: Calbindin 1". Retrieved 2018-10-04. Noble JW, Almalki R, Roe SM, Wagner A, Duman R, Atack JR (October 2018). "The ... Bauer MC, Nilsson H, Thulin E, Frohm B, Malm J, Linse S (April 2008). "Zn2+ binding to human calbindin D(28k) and the role of ... Tao L, Murphy ME, English AM (May 2002). "S-nitrosation of Ca(2+)-loaded and Ca(2+)-free recombinant calbindin D(28K) from ...
1-calbindin D9k reveals details of the stepwise structural changes along the Apo(Ca2+)II1(Ca2+)I,II2 binding pathway. ... Entity #1 , Chains: A CALBINDIN D9K protein, length: 76 (BLAST) Sequence Similarity Cutoff. Rank. Chains in Cluster. Cluster ID ... Solution structure of (CD2+)1-calbindin D9K reveals details of the stepwise structural changes along the apo (CA2+)II1 ( ...
1-calbindin D9k reveals details of the stepwise structural changes along the Apo(Ca2+)II1(Ca2+)I,II2 binding pathway. ... CALBINDIN D9K A 76 Bos taurus Mutation: P43G Details: BOVINE MINOR A FORM, CADMIUM-HALF-SATURATED, CADMIUM ION IS BOUND IN C- ... Solution structure of (CD2+)1-calbindin D9K reveals details of the stepwise structural changes along the apo (CA2+)II1 ( ...
Calbindin. Calbindin je termín označující skupinu transportních proteinů v buňkách tenkého střeva a v ledvinách. Tyto proteiny ...
Calbindin-D28k Antibody 14479-1-AP has been identified with IF, IHC, IP, WB, ELISA. 14479-1-AP detected 28 kDa band in mouse ... Calbindin-D28k Antibody 3 Publications. Rabbit Polyclonal, Catalog number: 14479-1-AP Featured Product KD/KO validated ... IHC result of Calbindin antibody (14479-1-AP, 1:5000 in 1% BSA 0.3%Tx-100 Tris buffer incubated at 4℃ overnight) with freshly ... IHC result of Calbindin antibody (14479-1-AP, 1:5000 in 1% BSA 0.3%Tx-100 Tris buffer incubated at 4℃ overnight) with freshly ...
anti-Calbindin 1, mAb (AF2E5) is a monoclonal antibody that crossreacts with human, mouse, rat protein. Works in ELISA, WB. ... Calbindin D28k (calbindin) is a hexa EF-hand protein of 261 residues with 59% sequence identity to calretinin. It is a single- ... Calbindin protects against apoptotic and necrotic cell death, suggesting its ability to buffer calcium. Calbindin has been ... CALB1; D-28K; CAB27; Calbindin; Calbindin D28; Vitamin D-dependent Calcium-binding Protein; Avian-type ...
The family of EF-hand type Ca2+-binding proteins includes Calbindin D28K, Calbindin D9K, S-100 and , Calgranulin A (also ... Calbindin D28K, also known as calbindin, CALB1, D-28K or vitamin D-dependent calcium-binding protein, is a 261-amino acid ... Calbindin; Calbindin D28; D 28K; D-28K; D28K; OTTHUMP00000166027; OTTHUMP00000225441; RTVL H protein; Vitamin D dependent ... Anti-Calbindin 1 (CALB1) Monoclonal Antibody(Clone: CALB1/3333). Product code: 36-3393. *specify in mg or ml ...
There is a paucity of information on the effects of calcium binding on calbindin D-28K structure. To further examine the ... Calbindin D-28K is a six-EF-hand calcium-binding protein found in the brain, peripheral nervous system, kidney, and intestine. ... mechanism and structural consequences of calcium binding to calbindin D-28K we performed detailed complementary heteronuclear ... Calbindin D-28K is a six-EF-hand calcium-binding protein found in the brain, peripheral nervous system, kidney, and intestine. ...
To further investigate the role of calbindin D28k in Alzheimers disease (AD); hippocampus, superior temporal gyrus and ... Calbindin D28k mRNA in hippocampus, superior temporal gyrus and cerebellum: comparison between control and Alzheimer disease ... To further investigate the role of calbindin D28k in Alzheimers disease (AD); hippocampus, superior temporal gyrus and ... K A Maguire-Zeiss 1 , Z W Li, L M Shimoda, R W Hamill ... 1 Department of Neurology, University of Rochester School of ...
2013 Mar;15(1):53-65. Research Support, N.I.H., Extramural; Review ... calbindin 1; SOD2, superoxide dismutase 2; BCL-2, B-cell CLL/lymphoma 2; DRD1, Dopamine receptor D1; SYN2, synapsin II; GFAP, ... Sibille E1.. Author information. 1. Department of Psychiatry, Center for Neuroscience, University of Pittsburgh, Pittsburgh, PA ... Figure 1.. Continuous and progressive gene expression changes in human prefrontal cortex. Age-dependent changes for a core set ...
The genomic mechanisms of vitamin D action rely on cross talk between 1α,25-dihydroxyvitamin D3 signaling pathways and that of ... 1α,25-dihydroxyvitamin D3 (also known as calcitriol), is a biologically active molecule required to maintain the physiological ... Insulin secretion (Calbindin 28K). Many systems Diverse cells and cancer cell lines. ↓ Cell growth (↓ c-Fos, ↓ c-Myc). ↑ ... Gill, R.K.; Christakos, S. Identification of sequence elements in mouse calbindin-d28k gene that confer 1,25-dihydroxyvitamin ...
It is encoded in humans by the CALB2 gene and was formerly known as calbindin-D29k. S100G, formerly calbindin 3 and calbindin- ... Calbindins are three different calcium-binding proteins: calbindin, calretinin and S100G. They were originally described as ... Calbindin acts as a calcium buffer and calcium sensor and can hold four Ca2+ in the EF-hands of loops EF1, EF3, EF4 and EF5. ... Calbindin 1 or simply calbindin was first shown to be present in the intestine in birds and then found in the mammalian kidney ...
NeuN and Calbindin). The VEGF receptor Flk-1 is highly expressed in the lateral dentate gyrus and ventricle wall (. FIGS. 18 ... 37: 1-109 (1985); Prasad and Balaram, CRC Crit. Rev. Biochem., 16: 307-348 (1984)); (ii) Nα-methylamino acids (see, e.g., Aubry ... 1 105 cells were plated in T75 culture flasks for long term passaging (10 ml of culture medium per flask) in NB/B27 medium. The ... Since Flk-1 is present and VEGF is spontaneously released into the medium by neural stem cells, it was tested whether VEGF and ...
However, lacZ-expressing cells are anti-calbindin, anti-vimentin, and anti-HPC-1, and chx10-negative (F, I, L, O), indicating ... calbindin (horizontal cell; D), vimentin (Müller glia; G), HPC-1 (amacrine cell;J), chx10 (bipolar cell;M), and lacZ (B, E, H, ... calbindin (horizontal cell; G), vimentin (Müller glia; J), HPC-1 (amacrine cell; M), and lacZ (B, E, H, K, N). Overlaid images ... against calbindin d-28k and against syntaxin (HPC-1) from Sigma (St. Louis, MO), and against vimentin from Zymed (San Francisco ...
N-S′, Double immunostaining with β-gal (green) and cell type-specific markers (red), such as calbindin (N-O′), Pax2 (P-Q′), and ... However, in the Atoh1Ptf1a/+;Tg-Atoh1-Cre;R26R mice, some β-gal-positive cells were immunoreactive to GABA, calbindin, and Pax2 ... 7G,G′, yellow arrows and arrowheads) but not calbindin (Fig. 7C,C′), also consistent with previous knowledge that Purkinje ... 6L-S′). In the Tg-Atoh1-Cre;R26R mice, β-gal-positive cells were negative for GABA (GABAergic neuron marker), calbindin ( ...
Goffigan-Holmes J, Sanabria D, DIaz J, Flock D, Chavez-Valdez R. Calbindin-1 Expression in the Hippocampus following Neonatal ...
The expression of calbindin 1 and 2 proteins in human tissues and common tumours outside the central nervous system ... The expression of calbindin 1 and 2 proteins in human tissues and common tumours outside the central nervous system ...
... calbindin-D9k (CaBP-9k) and calbindin-D28k (CaBP-28k), transient receptor potential cation channels (TRPV5 and TRPV6), Na+/Ca2+ ... 25-dihydroxyvitamin D3 regulate transcription of calcium transporter genes in calbindin-D9k knockout mice. Authors. Ko S.-H.; ... 25-dihydroxyvitamin D3 regulate transcription of calcium transporter genes in calbindin-D9k knockout mice ... exchanger 1 (NCX1) and plasma membrane calcium ATPase 1b (PMCA1b), in CaBP-9k KO mice. Wild-type (WT) and KO mice were provided ...
NMR investigation and secondary structure of domains I and II of rat brain calbindin D(28k) (1-93). ... NMR investigation and secondary structure of domains I and II of rat brain calbindin D(28k) (1-93). Together they form a ...
All of the doubly labeled (BrdU-FG) neurons also immunolabeled with the antibody to calbindin-D28k. Many doubly labeled (BrdU- ... and either calbindin-D28k or synaptophysin immunohistochemistry. A large proportion (up to 44%) of BrdU-labeled cells in the ... 1 The Salk Institute for Biological Studies, Laboratory of Genetics, La Jolla, California 92037, USA. ...
... but not calbindin-positive) periglomerular cells (PGCs), while ventral NSCs produce deep GCs and calbindin-positive (but not TH ... CalB, Calbindin; CalR, Calretinin; EPL, external plexiform layer; IPL, internal plexiform layer; GC, granule cell; GL, ... FIGURE 1. Figure 1. V-SVZ NSCs are regionally specified and generate unique subtypes of OB interneurons depending on their ... Cui, L., Qu, H., Xiao, T., Zhao, M., Jolkkonen, J., and Zhao, C. (2013). Stromal cell-derived factor-1 and its receptor CXCR4 ...
Calbindin is green, synaptophysin and GABABR are red, and Hoechst is blue. (E) Calbindin immunoreactivities of Purkinje cells ... Calbindin is green, and Hoechst is blue. (Scale bars: A, 1 mm; B, D, and E, 25 μm; C, 10 μm.) To eliminate variations due to ... Calbindin and RORα are green, Foxp2 and Foxp2 (R552H) are red, and Hoechst is blue. (C) Nuclear aggregation of Foxp2 (R552H) in ... 3 A). The calbindin-positive Purkinje cells were aligned in a continuous row but were sparsely localized in the folia (P10). ...
Calbindin 28K and calretinin are very similar calcium binding proteins which are both present in the central nervous system ( ... Calbindin 28K is also present in the endocrine system. We have examined the cellular distribution of calbindin in the ... Calbindin 28K and calretinin are very similar calcium binding proteins which are both present in the central nervous system ( ... Pochet R, Pipeleers DG and Malaisse WJ (1987). Calbindin D 27 kDa: preferential localization in non-B islet cells of the rat ...
DeFelipe J. Types of neurons, synaptic connections and chemical characteristics of cells immunoreactive for calbindin-D28K, ... 1.. Triarhou LC. The cytoarchitectonic map of Constantin von Economo and Georg N. Koskinas. In:Microstructural Parcellation of ... Part 1: surgical anatomy and morphometric analysis of the transsylvian and transcortical approaches to the insula. J Neurosurg ... 1.Department of Histology and EmbryologyEge University School of MedicineIzmirTurkey ...
0/calbindin; 0/zebrin II; EC 2.7.1.-/Phosphofructokinase-1, Type C ... Phosphofructokinase-1, Type C / analysis, metabolism. Polymerase Chain Reaction. Purkinje Cells / physiology*. RNA, Messenger ...
In previous investigations, the critical transcellular proteins, calbindin-D9k (CaBP-9k) and -D28k (CaBP-28k), were shown to ... ZO-1 and claudin 2, 10b, 12 and 15) in the duodenum of CaBP-9k- and/or -28k-deficient mice was examined. With a normal diet, ... Keywords: calbindin; transcellular pathway; paracellular pathway; calcium absorption; tight junction calbindin; transcellular ... Alteration of Tight Junction Gene Expression by Calcium- and Vitamin D-Deficient Diet in the Duodenum of Calbindin-Null Mice. ...
2. Binds to CALBINDIN. 3. Calcium in enterocytes transport by Ca2+-ATPase and 3Na+/Ca2+ exchanger ... 1. Begins in the stomach due to acidic pH and Pepsin. 2. Most digestion occurs in the Small Intestines by Pancreatic and Brush- ... 1. Digestion of lipid is completed in the Small Intestines. *By Pancreatic lipase, choleterol ester hydrolase, and ... Browse over 1 million classes created by top students, professors, publishers, and experts, spanning the worlds body of " ...
K. Sooy, J. Kohut, and S. Christakos, "The role of calbindin and 1,25dihydroxyvitamin D. 3. in the kidney," Current Opinion in ... M. Takashi, Y. Zhu, K. Miyake, and K. Kato, "Urinary 28-kD calbindin-D as a new marker for damage to distal renal tubules ... Meso Scale Discovery and Luminex Comparative Analysis of Calbindin D28K. Samer Sourial, Maritha Marcusson-Ståhl, and Karin ... S. Hasegawa, K. Kato, M. Takashi et al., "Increased levels of calbindin-D in serum and urine from patients treated by ...
View our list of human assays that have been tested for cross-reactivity to Cynomolgus Macaque and Rhesus, and mouse assays tested for cross-reactivity to rat samples.
  • Calbindin 1 is a protein that in humans is encoded by the CALB1 gene. (wikipedia.org)
  • Fig. 1: Formalin-fixed, paraffin-embedded human Kidney stained with Calbindin 1 Mouse Monoclonal Antibody (CALB1/3333). (abeomics.com)
  • Calbindin D28K, also known as calbindin, CALB1, D-28K or vitamin D-dependent calcium-binding protein, is a 261-amino acid protein with 6 EF-hand domains, 4 of which are active calcium-binding domains. (abeomics.com)
  • Calbindin 1 (Calb1) and three well-known zone and stripe markers, zebrin II, HSP25, and PLCβ4 have been used to explore possible alteration in zone and stripe. (pubmedcentralcanada.ca)
  • Rabbit IgG polyclonal antibody for Calbindin(CALB1) detection. (mybiosource.com)
  • The family of EF-hand type Ca2+-binding proteins includes Calbindin D28K, Calbindin D9K, S-100 and , Calgranulin A (also designated MRP8), Calgranulin B (also designated MRP14), Calgranulin C and the Parvalbumin family members, including Parvalbumin and Parvalbumin (also designated oncomodulin). (abeomics.com)
  • We measured the concentrations of the four main calcium-buffering proteins (calbindin-D28k, calretinin, parvalbumin-α, and parvalbumin-β) in rat cochlear hair cells in which Ca 2+ signaling is a central element of fast transduction and synaptic transmission. (jneurosci.org)
  • of the proteinaceous calcium buffer of outer hair cells in which the cell body contained parvalbumin-β (oncomodulin) and calbindin-D28k at levels equivalent to 5 m m calcium-binding sites. (jneurosci.org)
  • Our results indicate that, in animals with fully developed hearing, inner hair cells showed much smaller amounts of calcium buffer than outer hair cells, which contained parvalbumin-β and calbindin-D28k at levels equivalent to 5 m m calcium-binding sites. (jneurosci.org)
  • Here we present quantitative data on AHN in wild-derived mole-rats of 1 year and older, and briefly describe its anatomical context including markers of neuronal function (calbindin and parvalbumin). (frontiersin.org)
  • Calbindin-D, also known as Calbindin 1, is a Vitamin D-dependent cytoplasmic protein in the EF-hand calcium binding protein family that includes calmodulin, parvalbumin, troponin C, and S100. (neuromics.com)
  • This study was carried out to investigate the morphology, distribution and co-localization of calbindin D-28k and parvalbumin-containing GABAergic cells in the midbrain of the cat. (koreamed.org)
  • Calcium binding protein calbindin D-28k and parvalbumin immunoreactive neurons were mainly found in the red nucleus, substantia nigra, oculomotor nucleus and locus ceruleus of the cat midbrain. (koreamed.org)
  • 2. Parvalbumin immunoreactive cells in the red nucleus were more than twice in number compared to the calbindin D-28k immunoreactive cells. (koreamed.org)
  • 3. Calbindin immunoreactive cells in the substans nigr were more than twice in number compared to the parvalbumin immunoreactive cells. (koreamed.org)
  • 5. Calbindin D-28k and parvalbumin-immunoreactive cells were round, oval, spindle or polygonal in shape and were 15~20 micrometer in diameter. (koreamed.org)
  • The burst of calcium release from the ER of muscle cells is buffered by the presence of calcium-binding proteins such as calbindin-D9k and parvalbumin. (thefreedictionary.com)
  • Calcium binding proteins (CaBPs) such as calbindin D28-k, parvalbumin, and calretinin are able to bind Ca 2+ with high affinity. (hindawi.com)
  • Furthermore, loss of calbindin, neuropeptide Y, parvalbumin, and GAD65-positive interneurons in central networks collectively support the hypothesis that degeneration of GABAergic interneurons may be the cause of supraspinal GABAergic disinhibition. (elifesciences.org)
  • the Calreticulin deficiency-mediated increase in cell death was not prevented by calbindin-D28k or Parvalbumin. (antibodies-online.com)
  • For example, in birds, calbindin is strongly expressed in the tectofugal pathway, whereas parvalbumin (PV) is strongly expressed in the thalamofugal pathway. (cambridge.org)
  • Labeling for the 160 kDa neurofilament subunit, calbindin, and parvalbumin varied. (diva-portal.org)
  • Calbindin-D28K immunoreactivity in the human cerebellar cortex. (nih.gov)
  • Decreased hippocampal expression of calbindin D28K and cognitive impairment in MELAS. (nih.gov)
  • Title: Role of Calbindin-D28k in Diabetes-Associated Advanced Glycation End-Products-Induced Renal Proximal Tubule Cell Injury. (nih.gov)
  • Calbindin-D28k is a member of the calcium-binding protein superfamily that includes calmodulin and troponin C. It is a cytosolic calcium binding protein highly expressed in the distal tubule, intestines, central nervous system, primary murine osteoblast cells and in several other organs. (ptglab.com)
  • In neuronal cells, Calbindin D28K modulates calcium channel activity, calcium transients and intrinsic neuronal firing activity. (abeomics.com)
  • Also, Calbindin D28K has been implicated to play a role in apoptosis and microtubule function. (abeomics.com)
  • The effect(s) of oral calcium and vitamin D3 were examined on the expression of duodenal and renal active calcium transport genes, i.e., calbindin-D9k (CaBP-9k) and calbindin-D28k (CaBP-28k), transient receptor potential cation channels (TRPV5 and TRPV6), Na+/Ca2+ exchanger 1 (NCX1) and plasma membrane calcium ATPase 1b (PMCA1b), in CaBP-9k KO mice. (ewha.ac.kr)
  • Three weeks after FG injections, sections were analyzed for BrdU immunoreactivity (proliferative label), FG retrograde label, and either calbindin-D28k or synaptophysin immunohistochemistry. (nih.gov)
  • All of the doubly labeled (BrdU-FG) neurons also immunolabeled with the antibody to calbindin-D28k. (nih.gov)
  • Calbindin D28k is a member of a large family of intracellular calcium-binding proteins, containing EF-hand calcium binding motifs, and related to calmodulin and troponin-C. The biological roles of Calbindin D28k include calcium regulation and calcium-dependent signalling in neurons and during development. (novusbio.com)
  • Decreases in Calbindin D28k abundance, or loss of Calbindin D28k immunoreactivity, is found in models of neurological disorders such as epilepsy, and in neurodegenerative diseases. (novusbio.com)
  • This work builds on earlier observations that described the reduction in levels of calbindin D28K, a high-affinity calcium-binding protein, in the brains of patients with various neurodegenerative diseases. (alzforum.org)
  • Careful immunochemical studies show that there are also significant reductions in the levels of calbindin D28K (CB) and c-Fos in the brains of these mice, and that these seem to correlate more with the levels of soluble A b peptide levels in brain extracts than with the amount of accumulated amyloid plaque. (alzforum.org)
  • Crystallographic structure of calcium loaded Calbindin-D28K. (proteopedia.org)
  • Calbindin-D28K is a widely expressed calcium-buffering cytoplasmic protein that is involved in many physiological processes. (proteopedia.org)
  • Many of the targets of calbindin-D28K are of therapeutic interest: for example, inositol monophosphatase, the putative target of lithium therapy in bipolar disorder. (proteopedia.org)
  • Presented here is the first crystal structure of human calbindin-D28K. (proteopedia.org)
  • There are significant deviations in the tertiary structure when compared with the NMR structure of rat calbindin-D28K (PDB entry 2g9b), despite 98% sequence identity. (proteopedia.org)
  • Small-angle X-ray scattering (SAXS) indicates that the crystal structure better predicts the properties of calbindin-D28K in solution compared with the NMR structure. (proteopedia.org)
  • Here, the first direct visualization of the calcium-binding properties of calbindin-D28K is presented. (proteopedia.org)
  • SAXS data collected in both the presence and absence of calcium indicate that there are no large structural differences in the globular structure of calbindin-D28K between the calcium-loaded and unloaded proteins. (proteopedia.org)
  • Noble JW, Almalki R, Roe SM, Wagner A, Duman R, Atack JR. The X-ray structure of human calbindin-D28K: an improved model. (proteopedia.org)
  • Identification of sequence elements in mouse calbindin-D28k gene that confer 1,25-dihydroxyvitamin D3- and butyrate-inducible responses. (jax.org)
  • Vitamin-D-dependent calcium binding proteins such as calbindin-D28K (28 kDa calcium binding proteins) have been shown to be regulated by 1,25(OH) 2 D 3 but the mechanisms controlling calbindin synthesis are still poorly understood in human osteoblast cell culture models. (biochemj.org)
  • Calbindin-D28K protein was identified only in cells arising from the sixth subculture, which exhibited a calcified matrix and all of the osteoblastic markers, e.g. (biochemj.org)
  • Moreover, vitamin D 3 enhanced calbindin-D28K synthesis as well as OC synthesis and alkaline phosphatase activity. (biochemj.org)
  • In conclusion, the studies in v itro described in the present paper indicate, for the first time, a possible role of calbindin-D28K in mineralized matrix formation in HBMSC. (biochemj.org)
  • Calbindin-D28k is a calcium binding protein with six EF hand domains. (rti.org)
  • Calbindin-D28k is unique in that it functions as both a calcium buffer and a sensor protein. (rti.org)
  • Calbindin-D28k is known to bind four calcium ions and upon calcium binding undergoes a conformational change. (rti.org)
  • The structure of apo calbindin-D28k is in an ordered state, transitioning into a disordered state as calcium is bound. (rti.org)
  • The solution structure of disulfide-reduced holo-calbindin-D28k has been determined by NMR, while the structure of apo calbindin-D28k has yet to be determined. (rti.org)
  • Differential surface modification of lysine and histidine residues analyzed by mass spectrometry has been used in this study to identify, for the first time, the specific regions of calbindin-D28k undergoing conformational changes between the holo and apo states. (rti.org)
  • Using differential surface modification in combination with mass spectrometry, EF hands 1 and 4 as well as the linkers before EF hand 1 and the linkers between EF hands 4 and 5 and EF hands 5 and 6 were identified as regions of conformational change between apo and holo calbindin-D28k. (rti.org)
  • It belongs to the calbindin family of calcium-binding proteins, along with calretinin (CALB2). (wikipedia.org)
  • Calbindins are three different calcium-binding proteins: calbindin, calretinin and S100G. (wikipedia.org)
  • In the brain, its synthesis is independent of vitamin-D. Calretinin, also known as calbindin 2, is a 29 kDa protein with 58% homology to calbindin 1 and principally found in nervous tissues. (wikipedia.org)
  • Calbindin 28K and calretinin are very similar calcium binding proteins which are both present in the central nervous system (CNS). (springer.com)
  • Finally, calcium binding proteins, calbindin and calretinin were localized to the inner retina whilst recoverin was localized to photoreceptors. (biomedsearch.com)
  • Two calcium binding proteins, calbindin and calretinin, have been reported to be expressed in abundance in Purkinje cells and other cell types in the cerebellum. (mybiosource.com)
  • Downregulation of calbindin 1, a calcium-binding protein, reduces the proliferation of osteosarcoma cells. (ptglab.com)
  • Calbindin D-28K is a six-EF-hand calcium-binding protein found in the brain, peripheral nervous system, kidney, and intestine. (rti.org)
  • Several animal studies have shown that BPA may disturb calcium metabolism by inducing or inhibiting the renal expression of a vitamin D-dependent calcium-binding protein, calbindin-D9k (CaBP-9k) (Kim et al. (thefreedictionary.com)
  • Downregulation of PCNA and calbindin-D9k protein levels after BPA exposure were confirmed by Western blot analysis (see Supplemental Material, Figure S1B,C). (thefreedictionary.com)
  • Studies in rats have shown that subcutaneous injection of p-NP in late pregnancy induces calbindin-D9k (CaBP-9k) mRNA and protein expression in maternal and neonatal uteri, suggesting its potential transfer through the placenta (Hong et al. (thefreedictionary.com)
  • Examples of differentially expressed representative genes include calbindin-D9k (vitamin D-dependent calcium-binding protein), oxytocin, adipocyte complement related protein (30 kDa), lactate dehydrogenase A, and calcium-binding protein A6 (calcyclin). (thefreedictionary.com)
  • B- Add 1 µg of the recombinant protein to 1 ml of the diluted antibody solution and mix well. (prospecbio.com)
  • We show in gel-shift assays that the sequence within a putative vitamin-D-response element in the human calbindin-D9k promoter can bind expressed IPF-1/PDX-1 protein, although we cannot confirm binding of the vitamin-D-receptor protein. (biochemj.org)
  • E Coli-derived human Calbindin recombinant protein (Position: A2-E175). (mybiosource.com)
  • Calbindin is a calcium-binding protein belonging to the troponin C superfamily. (mybiosource.com)
  • While the expression level of the calbindin gene increases during the ovulatory cycle at a time coincident with eggshell calcification, there is little or no change in the tissue levels of calbindin protein, indicating post-translational control of calbindin levels [ 4 ]. (biomedcentral.com)
  • Protein Science, 11(Suppl 1). (etis.ee)
  • 1: The Lise Meitner Symposium: Current Progress in Protein Folding and Design, March 26-27, 2002, Lund, Sweden. (etis.ee)
  • Calbindin D9k: A Protein Optimized for Calcium Binding at Neutral pH. (etis.ee)
  • Defining heterochromatin in C. elegans through genome-wide analysis of the heterochromatin protein 1 homolog HPL-2. (abcam.com)
  • See the article " The autophagy effector Beclin 1: a novel BH3-only protein " in Oncogene , volume 5 on page S137. (pubmedcentralcanada.ca)
  • Here we report that beclin 1, a protein with a key role in autophagy, was decreased in affected brain regions of patients with Alzheimer disease (AD) early in the disease process. (pubmedcentralcanada.ca)
  • Familial Alzheimer disease (AD) mutations increase the toxicity and amyloidogenicity of the amyloid β (Aβ) peptide, placing disruption of amyloid precursor protein (APP) metabolism and Aβ production at the center of AD pathogenesis ( 1 ). (pubmedcentralcanada.ca)
  • The cells are stained with a standard Nissl stain (purple) and with calbindin , a calcium‐binding protein that immunostains Purkinje cells (large brown stained cells). (els.net)
  • ELISA (For coating, order antibody without BSA);Immunohistochemistry (Formalin-fixed) (1-2µg/ml for 30 minutes at RT),(Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined. (abeomics.com)
  • Calbindin D staining of paraffin-embedded human cerebellum and frozen rat hypothalamus sections using 25 µg/mL mouse anti-human Calbindin D monoclonal antibody. (neuromics.com)
  • Staining is shown in the medial vestibular nucleus using 25 µg/mL mouse anti-human Calbindin D monoclonal antibody. (neuromics.com)
  • For adsorption we suggest the following procedureA- Dilute 1 µl of the monoclonal antibody against calbindin D-28k in 5 ml of the usual buffer for immunohistochemistry (final dilution 1:5'000). (prospecbio.com)
  • There are currently no images for Calbindin D-28K Antibody (NBP1-35393). (novusbio.com)
  • Calbindin antibody is often used as a marker for cerebellum Purkinje cells. (novusbio.com)
  • IHC analysis of Calbindin using anti-Calbindin antibody (MBS176994). (mybiosource.com)
  • The tissue section was then incubated with 1ug/ml rabbit anti-Calbindin Antibody (MBS176994) overnight at 4 degree C. Biotinylated goat anti-rabbit IgG was used as secondary antibody and incubated for 30 minutes at 37 degree C. The tissue section was developed using Strepavidin-Biotin-Complex (SABC) with DAB as the chromogen. (mybiosource.com)
  • The structure of rat calbindin was originally solved by nuclear magnetic resonance and was one of the largest proteins then to be determined by this technique. (wikipedia.org)
  • Unlike calbindin 1 and 2, S100G is a member of the S100 family of calcium-binding proteins. (wikipedia.org)
  • In previous investigations, the critical transcellular proteins, calbindin-D 9k (CaBP-9k) and -D 28k (CaBP-28k), were shown to affect other transcellular pathways by buffering intracellular calcium concentrations. (mdpi.com)
  • Calbindins are Ca-binding proteins belonging to the troponin C superfamily. (prospecbio.com)
  • Finally, mice lacking the homeodomain proteins DLX-1 and DLX-2 show no detectable cell migration from the subcortical telencephalon to the neocortex and also have few GABA-expressing cells in the neocortex. (sciencemag.org)
  • Uptake of 45 Ca induced into the matrix by 1,25(OH) 2 D 3 supports the hypothesis that the calcium-enriched matrix could trap calbindin-D proteins. (biochemj.org)
  • To reach their native conformation, many secretory proteins require the formation of intra- or inter-molecular disulfide bonds (1). (cellsignal.com)
  • Based on micropuncture experiments and the conspicuous localization of transport proteins, active Mg 2+ transport is confined to the DCT1 and DCT2 segments, whereas active Ca 2+ reabsorption mainly occurs along the DCT2 and CNT segments ( Figure 1 ). (asnjournals.org)
  • Calbindin is a vitamin D-responsive gene in many tissues, in particular the chick intestine, where it has a clear function in mediating calcium absorption. (wikipedia.org)
  • It is encoded in humans by the CALB2 gene and was formerly known as calbindin-D29k. (wikipedia.org)
  • Hwang I, Yang H, Kang H-S, Ahn C, Hong E-J, An B-S, Jeung E-B. Alteration of Tight Junction Gene Expression by Calcium- and Vitamin D-Deficient Diet in the Duodenum of Calbindin-Null Mice. (mdpi.com)
  • Calbindin-D9K gene expression in rat chorioallantoic placenta is not regulated by 1,25-dihydroxyvitamin D3. (thefreedictionary.com)
  • Calbindin-D9K (CaBP9K) gene: a model for studying the genomic actions of cacitriol and calcium in mammals. (thefreedictionary.com)
  • The human superoxide dismutase 1 ( SOD1 ) gene is responsible for neutralizing supercharged oxygen radicals within the cell. (pubmedcentralcanada.ca)
  • The human superoxide dismutase 1 ( SOD1 ) gene is located on chromosome 21 and functions to produce the enzyme Cu/Zn SOD1, which neutralizes superoxide (oxygen) radicals within cells. (pubmedcentralcanada.ca)
  • Peak steady-state mRNA levels of the vitamin D-dependent calbindin-D9K gene were induced by 1,25(OH)2D more rapidly in the DBP-/- mice. (jci.org)
  • 13. A method of increasing the number of dopaminergic neurons in a patient suffering from Parkinson's disease or Parkinsonian disorders comprising the step of infusing the central nervous system of said patient with an amount of PDGF-BB of between 0.1 ng/kg/day to 1 μg/kg/day to increase the number of dopaminergic neurons. (google.com)
  • However, as we discuss below, the NSCs, progenitors, and signaling that allow for new neurons to be born and the mechanisms that permit young neurons to migrate and integrate within the adult brain, do not seem to be intended for brain repair (summarized in Table 1 ). (frontiersin.org)
  • Calbindin-D protects neurons from excitotoxic and apoptotic cell death by buffering excess calcium. (neuromics.com)
  • Calbindin D-28K is found predominantly in subpopulations of central and peripheral nervous system neurons, and in certain epithelial cells involved in Ca2+ transport such as distal tubular cells and cortical collecting tubules of the kidney, and in enteric neuroendocrine cells. (prospecbio.com)
  • This cortical grid is formed by patches of calbindin-positive pyramidal neurons in layer 2 of medial entorhinal cortex (MEC). (royalsocietypublishing.org)
  • Enteric and vagal neurons positive for glp1r were activated by GLP-1 and may contribute to intestinal and central responses to locally released GLP-1, such as regulation of intestinal secretomotor activity and appetite. (diabetesjournals.org)
  • The neurodegenerative disorder spinocerebellar ataxia type 1 (SCA1) affects the cerebellum and inferior olive, though previous research has focused primarily on the cerebellum. (elifesciences.org)
  • The cerebellum is derived from the most anterior segment of the hindbrain, rhombomere 1 (r1). (biologists.org)
  • [1] In humans, the cerebellum plays an important role in motor control . (wikipedia.org)
  • Calbindin 1 or simply calbindin was first shown to be present in the intestine in birds and then found in the mammalian kidney. (wikipedia.org)
  • S100G, formerly calbindin 3 and calbindin-D9k, is present in mammalian enterocytes (epithelial cells of the intestine). (wikipedia.org)
  • Epithelial and neuronal calbindin in avian intestine: an immunohistochemical study. (springer.com)
  • 1. increase calcium and phosphate absorption in the kidneys, intestine and bones. (brainscape.com)
  • one of these, known as IPF-1 or PDX-1, co-localizes in the intestine with calbindin-D9k. (biochemj.org)
  • GLP1R is a high-affinity receptor for "active" GLP-1, a term encompassing GLP-1(7-36)amide and GLP-1(7-37) that are released postprandially from enteroendocrine L-cells in the epithelium of the small and large intestine ( 8 ). (diabetesjournals.org)
  • Increased levels of calbindin-D in serum and urine from patients treated by extracorporeal shock wave lithotripsy," The Journal of Urology , vol. 149, no. 6, pp. 1414-1418, 1993. (hindawi.com)
  • the presence of calbindin increases the amount of calcium crossing the cell without raising the free concentration. (wikipedia.org)
  • We also describe the presence of calbindin in RINm5F cells, an insulin-producing tumor cell line derived from a radiationinduced rat insulinoma. (springer.com)
  • A calbindin 29 KDA: a new neuronal protien. (springer.com)
  • Heterozygous deletion of beclin 1 ( Becn1 ) in mice decreased neuronal autophagy and resulted in neurodegeneration and disruption of lysosomes. (pubmedcentralcanada.ca)
  • We conclude that beclin 1 deficiency disrupts neuronal autophagy, modulates APP metabolism, and promotes neurodegeneration in mice and that increasing beclin 1 levels may have therapeutic potential in AD. (pubmedcentralcanada.ca)
  • What about cross breeding knock out mice for calbindin and APP transgenic mice? (alzforum.org)
  • Frank LaFerla, of the University of California, Irvine, strengthened the emerging connection between amyloid-β and tau as part of his laboratory's ongoing analysis of the triple transgenic mice expressing APP, PS-1, and tau mutations. (alzforum.org)
  • Administration of a lentiviral vector expressing beclin 1 reduced both intracellular and extracellular amyloid pathology in APP transgenic mice. (pubmedcentralcanada.ca)
  • Recientes caracterizaciones en los cambios en la expresión génica dependiente de la edad han mostrado que el envejecimiento del cerebro humano requiere de un conjunto específico de vías biológicas en un continuo a través del curso de toda la vida, y que los mismos genes que están asociados con el envejecimiento normal se implican frecuentemente y de igual forma en la depresión como en otros trastornos cerebrates. (nih.gov)
  • In the present study, the effect of dietary calcium and/or vitamin D supplementation on the expression of tight junction genes ( occludin , ZO-1 and claudin 2 , 10b, 12 and 15 ) in the duodenum of CaBP-9k- and/or -28k-deficient mice was examined. (mdpi.com)
  • Title: Downregulation of Calbindin 1 by miR-454-3p Suppresses Cell Proliferation in Nonsmall Cell Lung Cancer In Vitro. (nih.gov)
  • To further examine the mechanism and structural consequences of calcium binding to calbindin D-28K we performed detailed complementary heteronuclear NMR and microelectrospray mass spectrometry investigations of the calcium-induced conformational changes of calbindin D-28K. (rti.org)
  • Expression of S100G, like that of calbindin 1, is stimulated by the active vitamin D metabolite, calcitriol although the precise mechanisms are still controversial. (wikipedia.org)
  • Calbindin-1 Expression in the Hippocampus following Neonatal Hypoxia-Ischemia and Therapeutic Hypothermia and Deficits in Spatial Memory. (jhmi.edu)
  • Goffigan-Holmes J , Sanabria D, DIaz J, Flock D, Chavez-Valdez R. Calbindin-1 Expression in the Hippocampus following Neonatal Hypoxia-Ischemia and Therapeutic Hypothermia and Deficits in Spatial Memory. (jhmi.edu)
  • Calbindin-D9k (CaBP9k) localization and levels of expression in trophoblast cells from human term placenta. (thefreedictionary.com)
  • Stimulation of calbindin-D9k mRNA expression in the rat uterus by octyl-phenol, nonylphenol and bisphenol. (thefreedictionary.com)
  • Tetrabromodiphenyl other (BDE-47) evokes estrogenicity and calbindin-D9k expression through an estrogen receptor-mediated pathway in the uterus of immature rats. (thefreedictionary.com)
  • This indicates that other elements are also needed for the control of human calbindin-D9k expression. (biochemj.org)
  • In vitro analyses suggest that Shp2 mediates basic fibroblast growth factor signals in stimulating self-renewing proliferation of NSCs, partly through control of Bmi-1 expression. (asm.org)
  • A higher rate of eggshell calcification may be correlated with a significantly higher level of calbindin mRNA expression that peaks at 16 h compared with 0-4.5 h of post-oviposition time [ 6 ]. (biomedcentral.com)
  • Argininosuccinate Synthase 1-Deficiency Enhances the Cell Sensitivity to Arginine through Decreased DEPTOR Expression in Endometrial Cancer. (abcam.com)
  • The sequence of calbindin is 263 residues in length and has only one chain. (wikipedia.org)
  • Focusing of the Electrostatic Potential at EF-Hands of Calbindin D9k: Titration of Acidic Residues. (etis.ee)
  • Ionization Behavior of Acidic Residues in Calbindin D9k. (etis.ee)
  • Measurement and Modelling of Sequence-Specific pKa Values of Lysine Residues in Calbindin D9k. (etis.ee)
  • In 2018 the X-ray crystal structure of human calbindin was published (PDB entry 6FIE). (wikipedia.org)
  • We have examined the cellular distribution of calbindin in the pancreatic endocrine cells of chick, rat and human and found variable distribution among the different endocrine cell types. (springer.com)
  • Parmentier M, Lawson DEM, and Vassart G (1987) Human calbindin complementary DNA sequence. (springer.com)
  • 11. A method for inducing the in situ proliferation or differentiation of neural stem cells or neural progenitor cells located in a neural tissue of a human, the method comprising administering an amount of PDGF-BB of between 0.1 ng/kg/day to 1 μg/kg/day, to the neural tissue to induce the proliferation or differentiation of the neural stem cells or neural progenitor cells. (google.com)
  • The metabolite of vitamin D, 1α,25-dihydroxyvitamin D 3 (also known as calcitriol), is a biologically active molecule required to maintain the physiological functions of several target tissues in the human body from conception to adulthood. (mdpi.com)
  • G. Toedter, K. Hayden, C. Wagner, and C. Brodmerkel, "Simultaneous detection of eight analytes in human serum by two commercially avaliable platforms for multiplex cytokine analysis," Clinical and Vaccine Immunology , vol. 15, no. 1, pp. 42-48, 2008. (hindawi.com)
  • Human, mouse, and rat Calbindin-D share 99% amino acid sequence identity. (neuromics.com)
  • We report studies of the human calbindin-D9k promoter. (biochemj.org)
  • Differences between the reported sequences of the human calbindin-D9k promoter were first clarified before undertaking a functional analysis of this sequence. (biochemj.org)
  • Human Calbindin shares 99% amino acid (aa) sequence identity with mouse and rat Calbindin. (mybiosource.com)
  • Calbindin was detected in paraffin-embedded section of Human Intestinal Cancer Tissue. (mybiosource.com)
  • 6fie is a 1 chain structure with sequence from Human . (proteopedia.org)
  • The human bone marrow stromal cells (HBMSC) described in this paper developed a calcified matrix, expressed osteocalcin (OC), osteopontin (OP) and responded to 1,25(OH) 2 D 3 . (biochemj.org)
  • Calbindin-D9k is expressed in the cytoplasm of intestinal cells, where it is critical for dietary calcium absorption. (biochemj.org)
  • Section I. History, Chemistry Metabolism, Circulation & Regulation 1. (indigo.ca)
  • GLP-1 is an intestinal hormone with widespread actions on metabolism. (diabetesjournals.org)
  • 1α,25-Dihydroxyvitamin D 3 [1,25(OH) 2 D 3 ] is known to modulate Ca 2+ metabolism in several cell types. (biochemj.org)
  • 1993 Apr;18(1-2):32-42 Reduction of calbindin-28k mRNA levels in Alzheimer as compared to Huntington hippocampus. (alzforum.org)
  • Nonetheless, there is no homology between calbindin 1 and S100G, apart from their calcium binding domains (EF-hands): S100G has two EF-hands, and calbindin 1 has six. (wikipedia.org)
  • Correctly spliced gba mRNA was also present at low levels in these mice (hereafter referred to as K14-lnl/lnl mice), which explained the residual GCase activity in the K14-lnl/lnl tissues ( Fig. 1 D and E and SI Fig. 5 ). (pnas.org)
  • Mouse models for neurodegenerative disorders can be utilized to query the underlying differences and similarities in affected tissues, including the models generated for spinocerebellar ataxia type 1 (SCA1). (elifesciences.org)
  • Therapies based on GLP-1 are highly effective because they increase glucose-dependent insulin secretion in people with type 2 diabetes, but many reports suggest that GLP-1 has additional beneficial or, in some cases, potentially dangerous actions on other tissues, including the heart, vasculature, exocrine pancreas, liver, and central nervous system. (diabetesjournals.org)
  • Identifying which tissues express the GLP-1 receptor (GLP1R) is critical for the development of GLP-1-based therapies. (diabetesjournals.org)
  • Spinocerebellar ataxias (SCAs) are a genetically heterogeneous group of dominantly inherited neurodegenerative diseases characterized by progressive ataxia and Purkinje cell degeneration ( 1 - 3 ). (sciencemag.org)
  • Primary Antibodies are guaranteed for 1 year from date of receipt. (novusbio.com)
  • Our objective was to use a method independent of GLP1R antibodies to identify and characterize the targets of GLP-1 in mice. (diabetesjournals.org)
  • The objective of this study was to identify and characterize targets of GLP-1 by a method independent of the use of antibodies and to investigate whether glp1r is expressed in cells located close to enteroendocrine cells. (diabetesjournals.org)
  • 1% after 6 hours of exposure, while absorption through scratched and abraded skin was 57% over the same time period (Ilyin et al. (cdc.gov)
  • The primary subdivisions of the forebrain, including the neocortex and the basal ganglia, have distinct molecular and cellular properties ( 1 , 2 ). (sciencemag.org)
  • after 36 hours in culture, many labeled cells were detected in the neocortex (Fig. 1 A). This migration begins on about E12.5, as only a few labeled cells reached the cortex from E11.5 slices that were grown in culture for 36 hours ( 10 ). (sciencemag.org)
  • Many of the DiI-containing cells in the neocortex look like tangentially migrating cells, with leading processes tipped by growth cones and a trailing process (Fig. 1 , A and F). (sciencemag.org)
  • Calbindin is present in cells resembling the tangentially oriented GABA-containing cells that are found in the IZ of the developing neocortex ( 7 , 11 ). (sciencemag.org)
  • Immunohistochemistry was used to localize and measure substance P (SP), leucine-enkephalin (LENK), tyrosine hydroxylase (TH), and calbindin D28 (CAL) immunoreactivities. (stanford.edu)
  • 1 , 2 In the mature retina in mammals, Müller glia proliferate in the context of retinal injury or disease, contributing to gliosis and the formation of glial scars. (arvojournals.org)
  • This is incorrect as the resulting loss of rod and cone input to the neural retina constitutes deafferentation and remodeling at the cellular and molecular level becomes unavoidable (1-23). (utah.edu)
  • In contrast to normal retina (Fig. 1), AMD presents with another set of clinical findings including fundoscopic drusen or yellow spots as well as areas of chorioretinal atrophy seen in dry AMD also called geographic atrophy (GA) (Fig. 2). (utah.edu)
  • More surprising are reports that GLP-1 improves memory and learning ( 2 ), is cardioprotective during myocardial ischemia ( 3 ), promotes hepatocyte function ( 4 ), and increases pancreatic exocrine hyperplasia ( 5 ). (diabetesjournals.org)
  • The GLP-1 receptor (GLP1R) was cloned originally from pancreatic β-cells, where it is coupled to cyclic adenosine monophosphate (cAMP) production and enhanced glucose-dependent insulin release ( 7 ). (diabetesjournals.org)
  • They were found to exist in two distinct sizes with a molecular weight of approximately 9 kDa and 28 kDa, and they were renamed calbindins. (wikipedia.org)
  • En este artículo se revisan las caracteristicas distintivas del envejecimiento cerebral en términos de cambios en la función génica a lo largo del tiempo, y luego se enfoca en la evidencia que sustenta un acelerado envejecimiento molecular en la depresión. (nih.gov)
  • Calbindin Study: Is Calcium the Molecular Handle on Dysfunction in AD? (alzforum.org)
  • Urine appears to be the major route of excretion, with a urine:fecal ratio of approximately 3:1 in humans. (cdc.gov)
  • 4. The method of claim 1 wherein said method induces the differentiation, migration, proliferation or survival of neural stem cells or neural progenitor cell in said patient. (google.com)
  • e.g., calbindin in CA3 of naked mole-rats distributes similar to the pattern seen in early primate development, and calbindin staining extends into the stratum lacunosum-moleculare of Cape mole-rats. (frontiersin.org)
  • immunocytochemical evidence of calbindin 27-kDa in pineal transducers. (springer.com)
  • The results obtain by immunocytochemical observation were as follows : 1. (koreamed.org)
  • 1 Department of Neurology, University of Rochester School of Medicine and Dentistry, NY 14642, USA. (nih.gov)
  • Analytical Biochemistry , 317 (1), 59-66. (rti.org)
  • Calbindin-D is widely expressed and regulates calcium homeostasis. (neuromics.com)
  • Calbindin D 27 kDa: preferential localization in non-B islet cells of the rat pancreas. (springer.com)
  • In 1995, a milestone study demonstrated psoriatic plaque resolution following selective apoptosis of activated T cells, without affecting KC survival or activation, thus demonstrating the crucial role of the immune system, particularly of T cells, in the disease [ 1 ]. (mdpi.com)
  • Grid cells have been described mainly but not exclusively [ 2 ] in the medial entorhinal cortex (MEC) and form a robust allocentric representation of space [ 1 ]. (royalsocietypublishing.org)
  • The orientation of the grid is similar across cells locally [ 1 ] and perhaps also globally [ 3 - 5 ]. (royalsocietypublishing.org)
  • The phase of grid cells varies locally [ 1 ]. (royalsocietypublishing.org)
  • 2 . The method of claim 1 wherein the cells are exposed to SHH between 6-7 days. (google.es)
  • 3 . A population of cells created by the method of claim 1 . (google.es)
  • The arrow indicates the cell shown in ( F ). Analysis of GABA- ( B through E ) and calbindin- ( G through J ) expressing cells in slice cultures. (sciencemag.org)
  • GABA (Fig. 1 , B through E) or calbindin (Fig. 1 , G through J) immunofluorescence was present in about 20% of DiI-labeled neocortical cells ( 12 ). (sciencemag.org)
  • GLP-1 is one of several metabolically active peptides that are released from enteroendocrine cells in the gut epithelium after food intake. (diabetesjournals.org)
  • Although believed to target β-cells through the bloodstream, GLP-1 is rapidly cleaved and inactivated by dipeptidyl peptidase 4 (DPP4) ( 9 ) once it enters the circulation. (diabetesjournals.org)
  • This has led to the idea that receptors located close to L-cells may act as local sensors of endogenous GLP-1 before it is inactivated. (diabetesjournals.org)
  • B and G) Low-power views of GABA (B) and calbindin (G) immunofluorescence. (sciencemag.org)